WorldWideScience

Sample records for search and rescue operations

  1. A versatile sensor network for urban search and rescue operations

    Science.gov (United States)

    Känsälä, Klaus; Korkalainen, Marko; Mäyrä, Aki

    2011-11-01

    The presentation is based in the research work carried out in EU funded project SGL for USaR (Second Generation Locator for Urban Search and Rescue Operations). The aim of this project is to develop wireless standalone communication system with embedded sensor network which can be globally used in rescue operations after accidents or terrorist attacks. The system should be able to operate without external support for several days: it should have autonomy with power supply and communication. The devices must be lightweight so that rescue team can easily carry them and finally they must be easy to install and use. The range of the wireless communication must cover an area of several square kilometers. The embedded sensor system must be able to detect sings of life but also detect hazards threatening the rescue operators thus preventing more accidents. It should also support positioning and digital mapping as well as the management of the search and rescue operation. This sensor network for urban search and rescue operations has been tested on a field conditions and it has proven to be robust and reliable and provides an energy efficient way of communication and positioning on harsh conditions.

  2. Strategies to improve sleep during extended search and rescue operations.

    Science.gov (United States)

    Jenkins, Jennifer Lee; Fredericksen, Kim; Stone, Roger; Tang, Nelson

    2007-01-01

    This study investigated strategies to improve sleeping conditions during search and rescue operations during disaster response. Forty members of the Montgomery County (Maryland) Urban Search and Rescue Team were surveyed for individual sleep habits and sleeping aids used during extended deployments. Team members were also asked to suggest methods to improve sleep on future deployments. The average amount of sleep during field operations was 5.4 hours with a range of 4-8 hours. Eight percent surveyed would prefer another schedule besides the 12-hour work day, all of whom proposed three 8-hour shifts. Fifteen percent of participants were interested in a pharmacological sleeping aid. Fifty percent of search and rescue members interviewed would consider using nonpharmacological sleeping aids. Furthermore, 40% of participants stated they had successfully devised self-employed methods of sleep aids for previous deployments, such as ear plugs, massage, mental imagery, personal routines, music and headphones, reading, and blindfolds. This study suggests that availability of both pharmacological and nonpharmacological sleeping aids to search and rescue workers via the team cache could impact the quantity of sleep. Further investigation into methods of optimizing sleep during field missions could theoretically show enhanced performance through various aspects of missions including mitigation of errors, improved productivity, and improved overall physiological and emotional well-being of search and rescue personnel.

  3. The potential use of unmanned aircraft systems (drones) in mountain search and rescue operations.

    Science.gov (United States)

    Karaca, Yunus; Cicek, Mustafa; Tatli, Ozgur; Sahin, Aynur; Pasli, Sinan; Beser, Muhammed Fatih; Turedi, Suleyman

    2018-04-01

    This study explores the potential use of drones in searching for and locating victims and of motorized transportation of search and rescue providers in a mountain environment using a simulation model. This prospective randomized simulation study was performed in order to compare two different search and rescue techniques in searching for an unconscious victim on snow-covered ground. In the control arm, the Classical Line Search Technique (CLT) was used, in which the search is performed on foot and the victim is reached on foot. In the intervention arm, the Drone-snowmobile Technique (DST) was used, the search being performed by drone and the victim reached by snowmobile. The primary outcome of the study was the comparison of the two search and rescue techniques in terms of first human contact time. Twenty search and rescue operations were conducted in this study. Median time to arrival at the mannequin was 57.3min for CLT, compared to 8.9min for DST. The median value of the total searched area was 88,322.0m 2 for CLT and 228,613.0m 2 for DST. The median area searched per minute was 1489.6m 2 for CLT and 32,979.9m 2 for DST (pdrone using DST compared to the classical technique, and the victim can be located faster and reached earlier with rescuers transported by snowmobile. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Advances in search and rescue at sea

    Science.gov (United States)

    Breivik, Øyvind; Allen, Arthur Addoms; Maisondieu, Christophe; Olagnon, Michel

    2013-01-01

    A topical collection on "Advances in Search and Rescue at Sea" has appeared in recent issues of Ocean Dynamics following the latest in a series of workshops on "Technologies for Search and Rescue and other Emergency Marine Operations" (2004, 2006, 2008, and 2011), hosted by IFREMER in Brest, France. Here, we give a brief overview of the history of search and rescue at sea before we summarize the main results of the papers that have appeared in the topical collection.

  5. Job task characteristics of Australian emergency services volunteers during search and rescue operations.

    Science.gov (United States)

    Silk, Aaron; Lenton, Gavin; Savage, Robbie; Aisbett, Brad

    2018-02-01

    Search and rescue operations are necessary in locating, assisting and recovering individuals lost or in distress. In Australia, land-based search and rescue roles require a range of physically demanding tasks undertaken in dynamic and challenging environments. The aim of the current research was to identify and characterise the physically demanding tasks inherent to search and rescue operation personnel within Australia. These aims were met through a subjective job task analysis approach. In total, 11 criterion tasks were identified by personnel. These tasks were the most physically demanding, frequently occurring and operationally important tasks to these specialist roles. Muscular strength was the dominant fitness component for 7 of the 11 tasks. In addition to the discrete criterion tasks, an operational scenario was established. With the tasks and operational scenario identified, objective task analysis procedures can be undertaken so that practitioners can implement evidence-based strategies, such as physical selection procedures and task-based physical training programs, commensurate with the physical demands of search and rescue job roles. Practitioner Summary: The identification of physically demanding tasks amongst specialist emergency service roles predicates health and safety strategies which can be incorporated into organisations. Knowledge of physical task parameters allows employers to mitigate injury risk through the implementation of strategies modelled on the precise physical demands of the role.

  6. Cost and Operational Effectiveness Analysis of Aiternative Force Structures for Fulfillment of the United States Marine Corps Operational Support Airlift and Search and Rescue Missions

    National Research Council Canada - National Science Library

    Chase, Eric

    2000-01-01

    This thesis provides a preliminary cost and operational effectiveness analysis of alternative force structures for the United States Marine Corps operational support airlift and search and rescue missions...

  7. An operational search and rescue model for the Norwegian Sea and the North Sea

    Science.gov (United States)

    Breivik, Øyvind; Allen, Arthur A.

    A new operational, ensemble-based search and rescue model for the Norwegian Sea and the North Sea is presented. The stochastic trajectory model computes the net motion of a range of search and rescue objects. A new, robust formulation for the relation between the wind and the motion of the drifting object (termed the leeway of the object) is employed. Empirically derived coefficients for 63 categories of search objects compiled by the US Coast Guard are ingested to estimate the leeway of the drifting objects. A Monte Carlo technique is employed to generate an ensemble that accounts for the uncertainties in forcing fields (wind and current), leeway drift properties, and the initial position of the search object. The ensemble yields an estimate of the time-evolving probability density function of the location of the search object, and its envelope defines the search area. Forcing fields from the operational oceanic and atmospheric forecast system of The Norwegian Meteorological Institute are used as input to the trajectory model. This allows for the first time high-resolution wind and current fields to be used to forecast search areas up to 60 h into the future. A limited set of field exercises show good agreement between model trajectories, search areas, and observed trajectories for life rafts and other search objects. Comparison with older methods shows that search areas expand much more slowly using the new ensemble method with high resolution forcing fields and the new leeway formulation. It is found that going to higher-order stochastic trajectory models will not significantly improve the forecast skill and the rate of expansion of search areas.

  8. Monitoring and Information Fusion for Search and Rescue Operations in Large-Scale Disasters

    National Research Council Canada - National Science Library

    Nardi, Daniele

    2002-01-01

    ... for information fusion with application to search-and-rescue and large scale disaster relief. The objective is to develop and to deploy tools to support the monitoring activities in an intervention caused by a large-scale disaster...

  9. Amphibious Search and Rescue: Shaping the Future

    National Research Council Canada - National Science Library

    Dowling, Michael

    2002-01-01

    The current Amphibious Search and Rescue (ASAR) mission is outdated, lacks integration with the mission/doctrine of the amphibious force and fails to exploit the multi-mission and tactical capabilities of the MH-60S helicopter...

  10. Uncertainty, Alert and Distress: The Precarious Position of NGO Search and Rescue Operations in the Central Mediterranean

    OpenAIRE

    Smith, Adam

    2017-01-01

    The international framework for maritime search and rescue relies on state actors establishing regions of responsibility supported by private shipmasters acting in compliance with traditional duties to rescue persons in distress at sea. Despite revisions to the framework’s foundational treaty, questions persist about the extent of state responsibilities and the interaction between those responsibilities and international human rights law. Over the past three years, non-governmenta...

  11. Scientific management of Mediterranean coastal zone: a hybrid ocean forecasting system for oil spill and search and rescue operations.

    Science.gov (United States)

    Jordi, A; Ferrer, M I; Vizoso, G; Orfila, A; Basterretxea, G; Casas, B; Alvarez, A; Roig, D; Garau, B; Martínez, M; Fernández, V; Fornés, A; Ruiz, M; Fornós, J J; Balaguer, P; Duarte, C M; Rodríguez, I; Alvarez, E; Onken, R; Orfila, P; Tintoré, J

    2006-01-01

    The oil spill from Prestige tanker showed the importance of scientifically based protocols to minimize the impacts on the environment. In this work, we describe a new forecasting system to predict oil spill trajectories and their potential impacts on the coastal zone. The system is formed of three main interconnected modules that address different capabilities: (1) an operational circulation sub-system that includes nested models at different scales, data collection with near-real time assimilation, new tools for initialization or assimilation based on genetic algorithms and feature-oriented strategic sampling; (2) an oil spill coastal sub-system that allows simulation of the trajectories and fate of spilled oil together with evaluation of coastal zone vulnerability using environmental sensitivity indexes; (3) a risk management sub-system for decision support based on GIS technology. The system is applied to the Mediterranean Sea where surface currents are highly variable in space and time, and interactions between local, sub-basin and basin scale increase the non-linear interactions effects which need to be adequately resolved at each one of the intervening scales. Besides the Mediterranean Sea is a complex reduced scale ocean representing a real scientific and technological challenge for operational oceanography and particularly for oil spill response and search and rescue operations.

  12. Intelligent Robot-assisted Humanitarian Search and Rescue System

    Directory of Open Access Journals (Sweden)

    Henry Y. K. Lau

    2009-11-01

    Full Text Available The unprecedented scale and number of natural and man-made disasters in the past decade has urged international emergency search and rescue communities to seek for novel technology to enhance operation efficiency. Tele-operated search and rescue robots that can navigate deep into rubble to search for victims and to transfer critical field data back to the control console has gained much interest among emergency response institutions. In response to this need, a low-cost autonomous mini robot equipped with thermal sensor, accelerometer, sonar, pin-hole camera, microphone, ultra-bright LED and wireless communication module is developed to study the control of a group of decentralized mini search and rescue robots. The robot can navigate autonomously between voids to look for living body heat and can send back audio and video information to allow the operator to determine if the found object is a living human. This paper introduces the design and control of a low-cost robotic search and rescue system based on an immuno control framework developed for controlling decentralized systems. Design and development of the physical prototype and the immunity-based control system are described in this paper.

  13. Intelligent Robot-Assisted Humanitarian Search and Rescue System

    Directory of Open Access Journals (Sweden)

    Albert W. Y. Ko

    2009-06-01

    Full Text Available The unprecedented scale and number of natural and man-made disasters in the past decade has urged international emergency search and rescue communities to seek for novel technology to enhance operation efficiency. Tele-operated search and rescue robots that can navigate deep into rubble to search for victims and to transfer critical field data back to the control console has gained much interest among emergency response institutions. In response to this need, a low-cost autonomous mini robot equipped with thermal sensor, accelerometer, sonar, pin-hole camera, microphone, ultra-bright LED and wireless communication module is developed to study the control of a group of decentralized mini search and rescue robots. The robot can navigate autonomously between voids to look for living body heat and can send back audio and video information to allow the operator to determine if the found object is a living human. This paper introduces the design and control of a low-cost robotic search and rescue system based on an immuno control framework developed for controlling decentralized systems. Design and development of the physical prototype and the immunity-based control system are described in this paper.

  14. Model-Based Systems Engineering in the Execution of Search and Rescue Operations

    Science.gov (United States)

    2015-09-01

    aspects of the architecture that were not apparent at the onset. This is a major benefit of employing multiple modeling techniques because each...still under development. Finding ways to improve the developing methods, or perhaps even expand 4 the incumbent ones, will benefit the wide array of...assets constantly monitor bingo conditions— the point at which the unit is no longer SAR capable and has just enough fuel remaining to execute a safe and

  15. Using social network analysis and agent-based modelling to explore information flow using common operational pictures for maritime search and rescue operations.

    Science.gov (United States)

    Baber, C; Stanton, N A; Atkinson, J; McMaster, R; Houghton, R J

    2013-01-01

    The concept of common operational pictures (COPs) is explored through the application of social network analysis (SNA) and agent-based modelling to a generic search and rescue (SAR) scenario. Comparing the command structure that might arise from standard operating procedures with the sort of structure that might arise from examining information-in-common, using SNA, shows how one structure could be more amenable to 'command' with the other being more amenable to 'control' - which is potentially more suited to complex multi-agency operations. An agent-based model is developed to examine the impact of information sharing with different forms of COPs. It is shown that networks using common relevant operational pictures (which provide subsets of relevant information to groups of agents based on shared function) could result in better sharing of information and a more resilient structure than networks that use a COP. SNA and agent-based modelling are used to compare different forms of COPs for maritime SAR operations. Different forms of COP change the communications structures in the socio-technical systems in which they operate, which has implications for future design and development of a COP.

  16. Human Detection and Classification of Landing Sites for Search and Rescue Drones

    NARCIS (Netherlands)

    N. Martins, Felipe; de Groot, Marc; Stokkel, Xeryus; Wiering, Marco

    2016-01-01

    Search and rescue is often time and labour intensive. We present a system to be used in drones to make search and rescue operations more effective. The system uses a drone downward facing camera to detect people and to evaluate potential sites as being safe or not for the drone to land. Histogram of

  17. Combat Search and Rescue in Desert Storm

    Science.gov (United States)

    2006-09-01

    in the United States also sup- ported civil SAR. Almost daily, the veterans of Southeast Asia were called upon to rescue lost hikers and foundering ...Ridge in the Persian Gulf. Under the NRCC, Combined Task Force (CTF) 151 served as the regional SAR controller for Battle Force Zulu in the Persian...was ZULU + 3 [i.e., Greenwich Mean Time plus three hours]. Saudi Arabia local time was ZULU + 3:30. All times in the log extracts that follow are

  18. An unmanned search and rescue mission

    Science.gov (United States)

    Novaro Mascarello, Laura; Quagliotti, Fulvia; Bertini, Mario

    2016-04-01

    The Remotely Piloted Aircraft Systems (RPAS) are becoming more and more powerful and innovative and they have an increased interest in civil applications, in particular, after natural hazard phenomena. The RPAS is useful in search and rescue missions in high mountain where scenarios are unfriendly and the use of helicopters is often not profitable. First, the unmanned configuration is safer because there is no hazards for human life that is not on board. Moreover, it is cheaper due to the use of electric propulsion instead of internal combustion engine and to its small dimensions and weights. Finally, the use of the RPAS is faster while the helicopter is often not available because is involved in other missions or it cannot be used if the search mission is in impervious scenario, such as forests with thick vegetation. For instance, the RPAS can be used after an avalanche when victims have little time to be saved before the death by hypothermia. In most conditions, the body maintains a healthy temperature. However, if it is exposed to cold temperatures, especially with a high cooling factor from wind and high humidity, for extended periods, the control mechanisms of the body may not be able to maintain a normal body temperature. When you lose more heat than the body can generate, it takes over hypothermia, defined as a body temperature below 35° C. Wet clothing, fall into cold water or not adequately cover themselves during the cold season, are all factors that can increase the chances of hypothermia. Signs and symptoms (tremor, slurred speech, breathing abnormally slow, cold and pale skin, loss of coordination, fatigue, lethargy or apathy, confusion or memory loss) usually develop slowly. People with hypothermia typically experience a gradual loss of mental acuity and physical capacity, and realize that you have need of emergency medical care. For these reasons, the use of an RPAS could be crucial for the survival of disappeared people in high mountain. In

  19. Autonomous underwater vehicle for research and rescue operations

    CSIR Research Space (South Africa)

    Holtzhausen S

    2008-11-01

    Full Text Available Autonomous under water vehicles are ideal platforms for search and rescue operations. They can also be used for inspection of underwater terrains. These vehicles need to be autonomous and robust to cope with unpredictable current and high pressures...

  20. Simulation Optimization of Search and Rescue in Disaster Relief Based on Distributed Auction Mechanism

    Directory of Open Access Journals (Sweden)

    Jian Tang

    2017-11-01

    Full Text Available In this paper, we optimize the search and rescue (SAR in disaster relief through agent-based simulation. We simulate rescue teams’ search behaviors with the improved Truncated Lévy walks. Then we propose a cooperative rescue plan based on a distributed auction mechanism, and illustrate it with the case of landslide disaster relief. The simulation is conducted in three scenarios, including “fatal”, “serious” and “normal”. Compared with the non-cooperative rescue plan, the proposed rescue plan in this paper would increase victims’ relative survival probability by 7–15%, increase the ratio of survivors getting rescued by 5.3–12.9%, and decrease the average elapsed time for one site getting rescued by 16.6–21.6%. The robustness analysis shows that search radius can affect the rescue efficiency significantly, while the scope of cooperation cannot. The sensitivity analysis shows that the two parameters, the time limit for completing rescue operations in one buried site and the maximum turning angle for next step, both have a great influence on rescue efficiency, and there exists optimal value for both of them in view of rescue efficiency.

  1. [Medical rescue of China National Earthquake Disaster Emergency Search and Rescue Team in Lushan earthquake].

    Science.gov (United States)

    Liu, Ya-hua; Yang, Hui-ning; Liu, Hui-liang; Wang, Fan; Hu, Li-bin; Zheng, Jing-chen

    2013-05-01

    To summarize and analyze the medical mission of China National Earthquake Disaster Emergency Search and Rescue Team (CNESAR) in Lushan earthquake, to promote the medical rescue effectiveness incorporated with search and rescue. Retrospective analysis of medical work data by CNESAR from April 21th, 2013 to April 27th during Lushan earthquake rescue, including the medical staff dispatch and the wounded case been treated. The reasonable medical corps was composed by 22 members, including 2 administrators, 11 doctors [covering emergency medicine, orthopedics (joints and limbs, spinal), obstetrics and gynecology, gastroenterology, cardiology, ophthalmology, anesthesiology, medical rescue, health epidemic prevention, clinical laboratory of 11 specialties], 1 ultrasound technician, 5 nurses, 1 pharmacist, 1 medical instrument engineer and 1 office worker for propaganda. There were two members having psychological consultants qualifications. The medical work were carried out in seven aspects, including medical care assurance for the CNESAR members, first aid cooperation with search and rescue on site, clinical work in refugees' camp, medical round service for scattered village people, evacuation for the wounded, mental intervention, and the sanitary and anti-epidemic work. The medical work covered 24 small towns, and medical staff established 3 medical clinics at Taiping Town, Shuangshi Town of Lushan County and Baoxing County. Medical rescue, mental intervention for the old and kids, and sanitary and anti-epidemic were performed at the above sites. The medical corps had successful evacuated 2 severe wounded patients and treated the wounded over thousands. Most of the wounded were soft tissue injuries, external injury, respiratory tract infections, diarrhea, and heat stroke. Compared with the rescue action in 2008 Wenchuan earthquake, the aggregation and departure of rescue team in Lushan earthquake, the traffic control order in disaster area, the self-aid and buddy aid

  2. Tactical mobile robots for urban search and rescue

    Science.gov (United States)

    Blitch, John; Sidki, Nahid; Durkin, Tim

    2000-07-01

    Few disasters can inspire more compassion for victims and families than those involving structural collapse. Video clips of children's bodies pulled from earthquake stricken cities and bombing sties tend to invoke tremendous grief and sorrow because of the totally unpredictable nature of the crisis and lack of even the slightest degree of negligence (such as with those who choose to ignore storm warnings). Heartbreaking stories of people buried alive for days provide a visceral and horrific perspective of some of greatest fears ever to be imagined by human beings. Current trends toward urban sprawl and increasing human discord dictates that structural collapse disasters will continue to present themselves at an alarming rate. The proliferation of domestic terrorism, HAZMAT and biological contaminants further complicates the matter further and presents a daunting problem set for Urban Search and Rescue (USAR) organizations around the world. This paper amplifies the case for robot assisted search and rescue that was first presented during the KNOBSAR project initiated at the Colorado School of Mines in 1995. It anticipates increasing technical development in mobile robot technologies and promotes their use for a wide variety of humanitarian assistance missions. Focus is placed on development of advanced robotic systems that are employed in a complementary tool-like fashion as opposed to traditional robotic approaches that portend to replace humans in hazardous tasks. Operational challenges for USAR are presented first, followed by a brief history of mobiles robot development. The paper then presents conformal robotics as a new design paradigm with emphasis on variable geometry and volumes. A section on robot perception follows with an initial attempt to characterize sensing in a volumetric manner. Collaborative rescue is then briefly discussed with an emphasis on marsupial operations and linked mobility. The paper concludes with an emphasis on Human Robot Interface

  3. Mountain Search and Rescue with Remotely Piloted Aircraft Systems

    Science.gov (United States)

    Silvagni, Mario; Tonoli, Andrea; Zenerino, Enrico; Chiaberge, Marcello

    2016-04-01

    Remotely Piloted Aircraft Systems (RPAS) also known as Unmanned Aerial Systems (UAS) are nowadays becoming more and more popular in several applications. Even though a complete regulation is not yet available all over the world, researches, tests and some real case applications are wide spreading. These technologies can bring many benefits also to the mountain operations especially in emergencies and harsh environmental conditions, such as Search and Rescue (SAR) and avalanche rescue missions. In fact, during last decade, the number of people practicing winter sports in backcountry environment is increased and one of the greatest hazards for recreationists and professionals are avalanches. Often these accidents have severe consequences leading, mostly, to asphyxia-related death, which is confirmed by the hard drop of survival probability after ten minutes from the burying. Therefore, it is essential to minimize the time of burial. Modern avalanche beacon (ARTVA) interface guides the rescuer during the search phase reducing its time. Even if modern avalanche beacons are valid and reliable, the seeking range influences the rescue time. Furthermore, the environment and morphologic conditions of avalanches usually complicates the rescues. The recursive methodology of this kind of searching offers the opportunity to use automatic device like drones (RPAS). These systems allow performing all the required tasks autonomously, with high accuracy and without exposing the rescuers to additional risks due to secondary avalanches. The availability of highly integrated electronics and subsystems specifically meant for the applications, better batteries, miniaturized payload and, in general, affordable prices, has led to the availability of small RPAS with very good performances that can give interesting application opportunities in unconventional environments. The present work is one of the outcome from the experience made by the authors in RPAS fields and in Mechatronics

  4. Where to go first: prioritization of damaged areas for allocation of Urban Search and Rescue (USAR operations (PI-USAR model

    Directory of Open Access Journals (Sweden)

    Reza Hassanzadeh

    2016-07-01

    Full Text Available This paper presents the development of a spatial model for the allocation of the Urban Search and Rescue (USAR operation by computing the priority index of damaged areas (PI-USAR model. The relevant prioritization criteria were identified through a literature review and interviews with 30 disaster managers. The relative importance of these criteria was computed as weights using an analytic hierarchy process (AHP method; the criteria were combined based on AHP rules and spatial multi-criteria decision-making analysis in geographic information system (GIS. The PI-USAR model was applied in the case study area of the Bam city in Iran and a priority map was produced indicating four highly prioritized areas. The model was validated by comparing the obtained priority map with the actual priority map (APM using fuzzy inference system and relative operating characteristic methods. The result suggested a good fit between the APM and the model's output. Sensitivity analyses were performed using the map removal and the single parameter methods. With the uncertainties and complexities that are inherent to the spatial data, spatial modelling and the earthquake phenomenon itself, the PI-USAR model offers some utility to disaster managers in understanding the significance of each criterion in the decision-making process and in identifying the highly prioritized areas for the allocation of USAR operations. However, its utility is best exploited in conjunction with other complementary sources of field data based on the immediate post-disaster situation.

  5. A Novel Reconfigurable Robot for Urban Search and Rescue

    Directory of Open Access Journals (Sweden)

    Houxiang Zhang

    2006-12-01

    Full Text Available This paper presents a novel mobile robot for urban search and rescue based on reconfiguration. The system consists of three identical modules; actually each module is an entire robotic system that can perform distributed activities. To achieve highly adaptive locomotion capabilities, the robot's serial and parallel mechanisms form an active joint, enabling it to change its shape in three dimensions. A docking mechanism enables adjacent modules to connect or disconnect flexibly and automatically. This mechanical structure and the control system are introduced in detail, followed by a description of the locomotion capabilities. In the end, the successful on-site tests confirm the principles described above and the robot's ability.

  6. A Novel Reconfigurable Robot for Urban Search and Rescue

    Directory of Open Access Journals (Sweden)

    Zhicheng Deng

    2008-11-01

    Full Text Available This paper presents a novel mobile robot for urban search and rescue based on reconfiguration. The system consists of three identical modules; actually each module is an entire robotic system that can perform distributed activities. To achieve highly adaptive locomotion capabilities, the robot's serial and parallel mechanisms form an active joint, enabling it to change its shape in three dimensions. A docking mechanism enables adjacent modules to connect or disconnect flexibly and automatically. This mechanical structure and the control system are introduced in detail, followed by a description of the locomotion capabilities. In the end, the successful on-site tests confirm the principles described above and the robot's ability.

  7. Robotic Platform for Automated Search and Rescue Missions of Humans

    Directory of Open Access Journals (Sweden)

    Eli Kolberg

    2013-02-01

    Full Text Available We present a novel type of model incorporating a special remote life signals sensing optical system on top of a controllable robotic platform. The remote sensing system consists of a laser and a camera. By properly adapting our optics and by applying a proper image processing algorithm we can sense within the field of view, illuminated by the laser and imaged by the camera, the heartbeats and the blood pulse pressure of subjects (even several simultaneously. The task is to use the developed robotic system for search and rescue mission such as saving survivals from a fire.

  8. Locating Direction Finders in a Generalized Search and Rescue Network

    Science.gov (United States)

    1991-03-01

    David A . Drake and Alfred B. Marsb. Conv-ersation at NationalI Security Agenc, 29 September 1990. 7. Daskin , Mark S. " A M-admum Fpeced Co-:efing...91 7 19 134 .flT/GORjEnSj9I-M LOCATING DIRECTION FIND’RS IN A GENERALIZED SEARCH AND RESCUE NETWORK THESIS Jean M. Steppe Captain, USAF AFIT/GOR/EN S...91-Mk-7 APPROVED FOR PUBLIC RELI ASE: DISTRIBUTION UNLIMITED. 1191-05734 .. 91.. .7 19 134 i i . nMIGOR4M.S/91-MI LOCATING DIRECTION FINDERS IW A

  9. Biobotic insect swarm based sensor networks for search and rescue

    Science.gov (United States)

    Bozkurt, Alper; Lobaton, Edgar; Sichitiu, Mihail; Hedrick, Tyson; Latif, Tahmid; Dirafzoon, Alireza; Whitmire, Eric; Verderber, Alexander; Marin, Juan; Xiong, Hong

    2014-06-01

    The potential benefits of distributed robotics systems in applications requiring situational awareness, such as search-and-rescue in emergency situations, are indisputable. The efficiency of such systems requires robotic agents capable of coping with uncertain and dynamic environmental conditions. For example, after an earthquake, a tremendous effort is spent for days to reach to surviving victims where robotic swarms or other distributed robotic systems might play a great role in achieving this faster. However, current technology falls short of offering centimeter scale mobile agents that can function effectively under such conditions. Insects, the inspiration of many robotic swarms, exhibit an unmatched ability to navigate through such environments while successfully maintaining control and stability. We have benefitted from recent developments in neural engineering and neuromuscular stimulation research to fuse the locomotory advantages of insects with the latest developments in wireless networking technologies to enable biobotic insect agents to function as search-and-rescue agents. Our research efforts towards this goal include development of biobot electronic backpack technologies, establishment of biobot tracking testbeds to evaluate locomotion control efficiency, investigation of biobotic control strategies with Gromphadorhina portentosa cockroaches and Manduca sexta moths, establishment of a localization and communication infrastructure, modeling and controlling collective motion by learning deterministic and stochastic motion models, topological motion modeling based on these models, and the development of a swarm robotic platform to be used as a testbed for our algorithms.

  10. Science in search and rescue in the aftermath of the massive February 2006 Philippine landslide

    Science.gov (United States)

    Lagmay, A. A.; Ong, J. T.; Rodolfo, R. S.; Tengonciang, A. P.; Soria, J. T.; Fernandez, D. D.; Lapus, M. R.; Baliatan, E. G.; Quimba, Z. P.; Uichanco, C. L.; Paguican, E. R.

    2006-12-01

    Technical advice by a team of geologists, geophysicists and meteorologists was provided during the search and rescue operations at ground zero of the February 2006 landslide in Southern Leyte, Philippines. An ad hoc geographic information system constructed from a cadastral plan, 1:50,000 topographic map, aerial imagery taken 7 days after the landslide, and a plot of the inventory of survivors, recovered bodies, personal articles and remnants of buildings, was used to narrow down the search in the large debris field. In particular, search parties were directed to transfer operations to an area where a community was believed to have been transported about 550 meters down slope of its original position. By the time rescuers concentrated their efforts to the new search site, the water table had risen, diminishing chances of finding survivors trapped under the water-drenched rubble. Improvised rain gauges placed around the debris field served as basis to call off search operations to prevent casualties among the ranks of rescue teams. The lessons learned from the Southern Leyte landslide may be applied in the construction of policies for disaster management. Because speed, accuracy and the maximum utilization of resources are required in handling search and rescue operations, a systematic and informed approach is imperative. Time is essential in such a critical situation; thus, following a standard rote of procedures can improve how civil authorities deal with large scale landslide calamities.

  11. Multi-robot Task Allocation for Search and Rescue Missions

    International Nuclear Information System (INIS)

    Hussein, Ahmed; Adel, Mohamed; Bakr, Mohamed; Shehata, Omar M; Khamis, Alaa

    2014-01-01

    Many researchers from academia and industry are attracted to investigate how to design and develop robust versatile multi-robot systems by solving a number of challenging and complex problems such as task allocation, group formation, self-organization and much more. In this study, the problem of multi-robot task allocation (MRTA) is tackled. MRTA is the problem of optimally allocating a set of tasks to a group of robots to optimize the overall system performance while being subjected to a set of constraints. A generic market-based approach is proposed in this paper to solve this problem. The efficacy of the proposed approach is quantitatively evaluated through simulation and real experimentation using heterogeneous Khepera-III mobile robots. The results from both simulation and experimentation indicate the high performance of the proposed algorithms and their applicability in search and rescue missions

  12. Civilian Helicopter Search and Rescue Accidents in the United States: 1980 Through 2013.

    Science.gov (United States)

    Worley, Gordon H

    2015-12-01

    Helicopters are commonly used in search and rescue operations, and accidents have occurred during helicopter search and rescue (HSAR) missions. The purposes of this study were to investigate whether the HSAR accident rate in the United States could be determined and whether any common contributing factors or trends could be identified. Searches were conducted of the National Transportation Safety Board aviation accident database, the records of the major search and rescue and air medical organizations, and the medical and professional literature for reports of HSAR accidents. A total of 47 civilian HSAR accidents were identified during the study. Of these, 43% involved fatal injuries, compared with a 19% fatality rate for US helicopter general aviation accidents during the same time period and a 40% rate for helicopter emergency medical services. The HSAR accidents carried a significantly higher risk of fatal outcomes when compared with helicopter general aviation accidents (2-tailed Fisher's exact test, P .05). The number of HSAR missions conducted annually could not be established, so an overall accident rate could not be calculated. Although the overall number of HSAR accidents is small, the percentage of fatal outcomes from HSAR accidents is significantly higher than that from general helicopter aviation accidents and is comparable to that seen for helicopter emergency medical services operations. Further study could help to improve the safety of HSAR flights. Copyright © 2015 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved.

  13. Ontological Reasoning for Human-Robot Teaming in Search and Rescue Missions

    NARCIS (Netherlands)

    Bagosi, T.; Hindriks, k.V.; Neerincx, M.A.

    2016-01-01

    In search and rescue missions robots are used to help rescue workers in exploring the disaster site. Our research focuses on how multiple robots and rescuers act as a team, and build up situation awareness. We propose a multi-agent system where each agent supports one member, either human or robot.

  14. A SOUND SOURCE LOCALIZATION TECHNIQUE TO SUPPORT SEARCH AND RESCUE IN LOUD NOISE ENVIRONMENTS

    Science.gov (United States)

    Yoshinaga, Hiroshi; Mizutani, Koichi; Wakatsuki, Naoto

    At some sites of earthquakes and other disasters, rescuers search for people buried under rubble by listening for the sounds which they make. Thus developing a technique to localize sound sources amidst loud noise will support such search and rescue operations. In this paper, we discuss an experiment performed to test an array signal processing technique which searches for unperceivable sound in loud noise environments. Two speakers simultaneously played a noise of a generator and a voice decreased by 20 dB (= 1/100 of power) from the generator noise at an outdoor space where cicadas were making noise. The sound signal was received by a horizontally set linear microphone array 1.05 m in length and consisting of 15 microphones. The direction and the distance of the voice were computed and the sound of the voice was extracted and played back as an audible sound by array signal processing.

  15. Search and rescue in collapsed structures: engineering and social science aspects.

    Science.gov (United States)

    El-Tawil, Sherif; Aguirre, Benigno

    2010-10-01

    This paper discusses the social science and engineering dimensions of search and rescue (SAR) in collapsed buildings. First, existing information is presented on factors that influence the behaviour of trapped victims, particularly human, physical, socioeconomic and circumstantial factors. Trapped victims are most often discussed in the context of structural collapse and injuries sustained. Most studies in this area focus on earthquakes as the type of disaster that produces the most extensive structural damage. Second, information is set out on the engineering aspects of urban search and rescue (USAR) in the United States, including the role of structural engineers in USAR operations, training and certification of structural specialists, and safety and general procedures. The use of computational simulation to link the engineering and social science aspects of USAR is discussed. This could supplement training of local SAR groups and USAR teams, allowing them to understand better the collapse process and how voids form in a rubble pile. A preliminary simulation tool developed for this purpose is described. © 2010 The Author(s). Journal compilation © Overseas Development Institute, 2010.

  16. SALVEREMO, an automatic system for the search and rescue in the wilderness and mountain areas

    Science.gov (United States)

    Penna, Roberto; Allasia, Walter; Bianchi, Luca; Licata, Enrico; Duranti, Pierluigi; Molino, Andrea; Bagalini, Enea; Sagliocco, Sergio; Scarafia, Simone; Prinetto, Paolo; Airofarulla, Giuseppe; Carelli, Alberto

    2016-04-01

    SALVEREMO project aims at designing and prototyping an innovative system for searching and rescuing individuals (especially hikers and mountaineers) who got lost or in peril in wilderness or mountain areas. It makes use of Remotely Piloted Aircraft System (RPAS) equipped with a sensor suite specifically selected according to the requirements identified involving alpine rescuers and government officials. The peculiarity of the proposed solution is the exploitation and integration of the special skill and expertise coming from different competence fields. It will dramatically decrease the searching time in the wilderness and remote areas off the beaten tracks, providing rescuers and operators with a decision support system increasing successful results and reducing rescue missions costs. The system benefits from the adoption of a scaled-down Base Transceiver Station (BTS) embarked in the payload sensor suite of a small RPAS that can be carried in a back pack of rescuers. A Software Defined Radio (SDR) board implementing the BTS protocol stack has been integrated in a complex sensor suite made up of open processing boards and camera devices. Moreover computer vision (CV) algorithms for real time pattern detection and image enhancements have been investigated for assisting the rescuers during the searching operations. An easy-to-use ground station application has been developed for speeding up the overall mission accomplishment. Aknowledgement SALVEREMO project is a research project co-funded by Regione Piemonte according to the call for proposal POR F.E.S.R. 2007/2013, "Linea di attività I.1.3-Innovazione e PMI - Polo della Meccatronica e dei Sistemi Avanzati di Produzione". The authors want to thank "Il Soccorso Alpino Italiano" for the invaluable support for establishing operative requirements.

  17. A simulated avalanche search and rescue mission induces temporary physiological and behavioural changes in military dogs.

    Science.gov (United States)

    Diverio, Silvana; Barbato, Olimpia; Cavallina, Roberta; Guelfi, Gabriella; Iaboni, Martina; Zasso, Renato; Di Mari, Walter; Santoro, Michele Matteo; Knowles, Toby G

    2016-09-01

    Saving human lives is of paramount importance in avalanche rescue missions. Avalanche military dogs represent an invaluable resource in these operations. However, their performance can be influenced by several environmental, social and transport challenges. If too severe, these are likely to activate a range of responses to stress, which might put at risk the dogs' welfare. The aim of this study was to assess the physiological and behavioural responses of a group of military dogs to a Simulated Avalanche Search and Rescue mission (SASR). Seventeen avalanche dogs from the Italian Military Force Guardia di Finanza (SAGF dogs) were monitored during a simulated search for a buried operator in an artificial avalanche area (SASR). Heart rate (HR), body temperature (RBT) and blood samples were collected at rest the day before the trial (T0), immediately after helicopter transport at the onset of the SASR (T1), after the discovery of the buried operator (T2) and 2h later (T3). Heart rate (HR), rectal body temperature (RBT), cortisol, aspartate aminotransferase (AST), creatine kinase (CK), non-esterified fatty acids (NEFA) and lactate dehydrogenase (LDH) were measured. During the search mission the behaviour of each SAGF dog was measured by focal animal sampling and qualitatively assessed by its handler and two observers. Inter-rater agreement was evaluated. Snow and environmental variables were also measured. All dogs successfully completed their search for the buried, simulated victim within 10min. The SASR was shown to exert significant increases on RBT, NEFA and cortisol (Pdog's search mission ability was found only for motivation, signalling behaviour, signs of stress and possessive reward playing. More time signalling was related to shorter search time. In conclusion, despite extreme environmental and training conditions only temporary physiological and behavioural changes were recorded in the avalanche dogs. Their excellent performance in successful simulated SASR

  18. GIS plays key role in NYC Rescue and Relief Operation

    Science.gov (United States)

    Showstack, Randy

    New York City, Sept. 17—The posters of missing loved ones are pasted onto New York City walls and street signs six days after 2 hijacked commercial airlines destroyed the World Trade Center in lower Manhattan on September 11. Several miles uptown from “ground zero,” heightened security hovers around the city's Office of Emergency Management rescue and relief command center, an around-the-clock operation. Police, firefighters, military, officials with the Federal Emergency Management Agency, communications technicians, and a beehive of others work in controlled chaos in this cavernous, convention center-sized hall, lined with computers and adorned with several American flags.After the original command center at 7 World Trade Center collapsed to rubble as an after-effect of the plane strikes, city officials scrambled to recreate it. Alan Leidner, director of New York's citywide geographic information systems (GIS), and who is with the Department of Information Technology and Telecommunications, knew that maps would be an integral component of the rescue and relief efforts. Maps provide emergency workers and others with accurate and detailed scientific data in the form of visual aids upon which they can make informed decisions.

  19. Satellite Search and Rescue System Studies: Alarm and Position Reporting.

    Science.gov (United States)

    alarm and position reporting ( ALPR ) techniques, and the operational or planned spacecraft which might be available for piggybacking the ALPR payload...Several system concepts were then developed to perform the ALPR functions. The candidates were screened and the preferred system concepts were chosen

  20. Exploring the ethical landscape of robot-assisted Search and Rescue

    NARCIS (Netherlands)

    Harbers, M.; Greeff, J. de; Kruijff-Korbayová, I.; Neerincx, M.A.; Hindriks, K.V.

    2017-01-01

    As robots are increasingly used in Search and Rescue (SAR) missions, it becomes highly relevant to study how SAR robots can be developed and deployed in a responsible way. In contrast to some other robot application domains, e.g. military and healthcare, the ethics of robot-assisted SAR are

  1. Cracking the humanitarian logistic coordination challenge: lessons from the urban search and rescue community.

    Science.gov (United States)

    Tatham, Peter; Spens, Karen

    2016-04-01

    The challenges of achieving successful inter-agency logistic coordination in preparing for and responding to natural disasters and complex emergencies are both well understood and well documented. However, although many of these challenges remain unresolved, the literature reveals that the organisations that form the urban search and rescue (USAR) community have attained a high level of coherence and interoperability that results in a highly efficient and effective response. Therefore, this paper uses the idea of 'borrowing' from other fields as it explores how the processes and procedures used by the USAR community might be applied to improve humanitarian logistic operations. The paper analyses the USAR model and explores how the resultant challenges might be addressed in a humanitarian logistic context. The paper recommends that further research be undertaken in order to develop a modified USAR model that could be operationalised by the international community of humanitarian logisticians. © 2016 The Author(s). Disasters © Overseas Development Institute, 2016.

  2. First Report of Using Portable Unmanned Aircraft Systems (Drones) for Search and Rescue.

    Science.gov (United States)

    Van Tilburg, Christopher

    2017-06-01

    Unmanned aircraft systems (UAS), colloquially called drones, are used commonly for military, government, and civilian purposes, including both commercial and consumer applications. During a search and rescue mission in Oregon, a UAS was used to confirm a fatality in a slot canyon; this eliminated the need for a dangerous rappel at night by rescue personnel. A second search mission in Oregon used several UAS to clear terrain. This allowed search of areas that were not accessible or were difficult to clear by ground personnel. UAS with cameras may be useful for searching, observing, and documenting missions. It is possible that UAS might be useful for delivering equipment in difficult areas and in communication. Copyright © 2017. Published by Elsevier Inc.

  3. Adaptive Engineering of an Embedded System, Engineered for use by Search and Rescue Canines

    Directory of Open Access Journals (Sweden)

    Cristina Ribeiro

    2011-06-01

    Full Text Available In Urban Search and Rescue (US&R operations, canine teams are deployed to find live patients, and save lives. US&R may benefit from increased levels of situational awareness, through information made available through the use of embedded systems attached to the dogs. One of these is the Canine Pose Estimation (CPE system. There are many challenges faced with such embedded systems including the engineering of such devices for use in disaster environments. Durability and wireless connectivity in areas with materials that inhibit wireless communications, the safety of the dog wearing the devices, and form factor must be accommodated. All of these factors must be weighed without compromising the accuracy of the application and the timely delivery of its data. This paper discusses the adaptive engineering process and how each of the unique challenges of emergency response embedded systems can be defined and overcome through effective design methods.

  4. Search and Rescue in Southeast Asia 1961-1975.

    Science.gov (United States)

    1975-01-01

    Operations Center diverted one of their C-123s to recon- noiter the area and act as airborne controller until Air Force HU-16s arrived from Karat . Once in...at the crash site the copilot of one of the Air America choppers was lowered on a cable. He found that the flyer had apparently died of injuries

  5. Dense 3D Map Construction for Indoor Search and Rescue

    DEFF Research Database (Denmark)

    Ellekilde, Lars-Peter; Huang, Shoudong; Miró, Jaime Valls

    2007-01-01

    The main contribution of this paper is a new simultaneous localization and mapping  SLAM algorithm for building dense three-dimensional maps using information ac- quired from a range imager and a conventional camera, for robotic search and rescue in unstructured indoor environments. A key challen...... invariant feature transformation SIFT feature detection and matching, random sampling consensus RANSAC , and least square 3D point sets ?tting. Experimental results are provided to demonstrate the effectiveness of the techniques developed....

  6. Search and Rescue in the High North: An Air Force Mission?

    Science.gov (United States)

    2013-12-01

    at the strange new things in the land of the midnight sun. What wouldn’t surprise him are the things that never change: six months of darkness ...8-98) Prescribed by ANSI Std Z39-18 November–December 2013 Air & Space Power Journal | 5 Conway Search and Rescue in the High North Feature tourism ...official sanction of the Department of Defense, Air Force, Air Education and Training Command, Air University, or other agencies or departments of

  7. Combat Search and Rescue: Restoring Promise to a Sacred Assurance

    Science.gov (United States)

    2017-05-01

    timely, efficient movement and enroute care of the wounded, injured, or ill persons from the battlefield and/or other locations to medical treatment ...President and CEO, John Piasecki, the Chief Technology Officer, Fred Piasecki, the test pilots Christopher Sullivan and Grey Hagwood, and their director of...January 1968., 1 [declassified] 30 The total geographic surface areas, water and land, of Laos, Vietnam, Cambodia, and Thailand as derived from the

  8. Maritime Search and Rescue via Multiple Coordinated UAS

    Science.gov (United States)

    2017-06-12

    partitioning method uses the underlying probability distribution assumptions to place that probability near the geometric center of the partitions. There...During partitioning the known locations are accommodated, but the unaccounted for objects are placed into geometrically unfavorable conditions. The...Zeitlin, A.D.: UAS Sence and Avoid Develop- ment - the Challenges of Technology, Standards, and Certification. Aerospace Sciences Meeting including

  9. Store separation trajectory predictions for maritime Search and Rescue (SAR)

    CSIR Research Space (South Africa)

    Akroyd, G

    2017-06-01

    Full Text Available tunnel testing, Computational Fluid Dynamics (CFD) nor Six Degree-of-Freedom (SDOF) trajectory simulations prior to flight testing. This might have been since the released stores were relatively light weight, the airspeeds low, and incidental contact...

  10. 47 CFR 80.1125 - Search and rescue coordinating communications.

    Science.gov (United States)

    2010-10-01

    ... Communications Commission, 445 12th Street, SW., Washington, DC (Reference Information Center) or at the National... sending the message; (5) The time when the distress situation has ceased; (6) The name and call sign of... identification of the station sending the message; (5) The time when distress situation has ceased; (6) The name...

  11. Intelligent systems for urban search and rescue: challenges and lessons learned

    Science.gov (United States)

    Jacoff, Adam; Messina, Elena; Weiss, Brian A.

    2003-09-01

    Urban search and rescue (USAR) is one of the most dangerous and time-critical non-wartime activities. Researchers have been developing hardware and software to enable robots to perform some search and rescue functions so as to minimize the exposure of human rescue personnel to danger and maximize the survival of victims. Significant progress has been achieved, but much work remains. USAR demands a blending of numerous specialized technologies. An effective USAR robot must be endowed with key competencies, such as being able to negotiate collapsed structures, find victims and assess their condition, identify potential hazards, generate maps of the structure and victim locations, and communicate with rescue personnel. These competencies bring to bear work in numerous sub-disciplines of intelligent systems (or artificial intelligence) such as sensory processing, world modeling, behavior generation, path planning, and human-robot interaction, in addition to work in communications, mechanism design and advanced sensors. In an attempt to stimulate progress in the field, reference USAR challenges are being developed and propagated worldwide. In order to make efficient use of finite research resources, the robotic USAR community must share a common understanding of what is required, technologically, to attain each competency, and have a rigorous measure of the current level of effectiveness of various technologies. NIST is working with partner organizations to measure the performance of robotic USAR competencies and technologies. In this paper, we describe the reference test arenas for USAR robots, assess the current challenges within the field, and discuss experiences thus far in the testing effort.

  12. A novel field search and rescue system based on SIM card location

    Science.gov (United States)

    Zhang, Huihui; Guo, Shutao; Cui, Dejing

    2017-06-01

    Nowadays, the rapid development of outdoor sports and adventure leads to the increase of the frequency of missing accidents. On the other hand, it becomes much more convenient and efficient for the criminals to escape with the help of new technologies. So we have developed a long-distance raids targeted field search and rescue system which utilizes RSSI ranging and Kalman filtering algorithm to realize remote positioning and dynamic supervision management only by a mobile phone with a SIM card, without any additional terminal equipment.

  13. FACILITATING THE 3D INDOOR SEARCH AND RESCUE PROBLEM: AN OVERVIEW OF THE PROBLEM AND AN ANT COLONY SOLUTION APPROACH

    Directory of Open Access Journals (Sweden)

    H. Tashakkori

    2016-10-01

    Full Text Available Search and rescue procedures for indoor environments are quite complicated due to the fact that much of the indoor information is unavailable to rescuers before physical entrance to the incident scene. Thus, decision making regarding the number of crew required and the way they should be dispatched in the building considering the various access points and complexities in the buildings in order to cover the search area in minimum time is dependent on prior knowledge and experience of the emergency commanders. Hence, this paper introduces the Search and Rescue Problem (SRP which aims at finding best search and rescue routes that minimize the overall search time in the buildings. 3D BIM-oriented indoor GIS is integrated in the indoor route graph to find accurate routes based on the building geometric and semantic information. An Ant Colony Based Algorithm is presented that finds the number of first responders required and their individual routes to search all rooms and points of interest inside the building to minimize the overall time spent by all rescuers inside the disaster area. The evaluation of the proposed model for a case study building shows a significant improve in search and rescue time which will lead to a higher chance of saving lives and less exposure of emergency crew to danger.

  14. Facilitating the 3D Indoor Search and Rescue Problem: An Overview of the Problem and an Ant Colony Solution Approach

    Science.gov (United States)

    Tashakkori, H.; Rajabifard, A.; Kalantari, M.

    2016-10-01

    Search and rescue procedures for indoor environments are quite complicated due to the fact that much of the indoor information is unavailable to rescuers before physical entrance to the incident scene. Thus, decision making regarding the number of crew required and the way they should be dispatched in the building considering the various access points and complexities in the buildings in order to cover the search area in minimum time is dependent on prior knowledge and experience of the emergency commanders. Hence, this paper introduces the Search and Rescue Problem (SRP) which aims at finding best search and rescue routes that minimize the overall search time in the buildings. 3D BIM-oriented indoor GIS is integrated in the indoor route graph to find accurate routes based on the building geometric and semantic information. An Ant Colony Based Algorithm is presented that finds the number of first responders required and their individual routes to search all rooms and points of interest inside the building to minimize the overall time spent by all rescuers inside the disaster area. The evaluation of the proposed model for a case study building shows a significant improve in search and rescue time which will lead to a higher chance of saving lives and less exposure of emergency crew to danger.

  15. A Combination of Terrain Prediction and Correction for Search and Rescue Robot Autonomous Navigation

    Directory of Open Access Journals (Sweden)

    Yan Guo

    2009-09-01

    Full Text Available This paper presents a novel two-step autonomous navigation method for search and rescue robot. The algorithm based on the vision is proposed for terrain identification to give a prediction of the safest path with the support vector regression machine (SVRM trained off-line with the texture feature and color features. And correction algorithm of the prediction based the vibration information is developed during the robot traveling, using the judgment function given in the paper. The region with fault prediction will be corrected with the real traversability value and be used to update the SVRM. The experiment demonstrates that this method could help the robot to find the optimal path and be protected from the trap brought from the error between prediction and the real environment.

  16. Design of a search and rescue terminal based on the dual-mode satellite and CDMA network

    Science.gov (United States)

    Zhao, Junping; Zhang, Xuan; Zheng, Bing; Zhou, Yubin; Song, Hao; Song, Wei; Zhang, Meikui; Liu, Tongze; Zhou, Li

    2010-12-01

    The current goal is to create a set of portable terminals with GPS/BD2 dual-mode satellite positioning, vital signs monitoring and wireless transmission functions. The terminal depends on an ARM processor to collect and combine data related to vital signs and GPS/BD2 location information, and sends the message to headquarters through the military CDMA network. It integrates multiple functions as a whole. The satellite positioning and wireless transmission capabilities are integrated into the motherboard, and the vital signs sensors used in the form of belts communicate with the board through Bluetooth. It can be adjusted according to the headquarters' instructions. This kind of device is of great practical significance for operations during disaster relief, search and rescue of the wounded in wartime, non-war military operations and other special circumstances.

  17. 33 CFR 150.504 - When must the operator service and examine lifeboat and rescue boat launching appliances?

    Science.gov (United States)

    2010-07-01

    ... and examine lifeboat and rescue boat launching appliances? 150.504 Section 150.504 Navigation and...: OPERATIONS Emergency and Specialty Equipment Launching Appliances § 150.504 When must the operator service and examine lifeboat and rescue boat launching appliances? (a) The operator must service launching...

  18. Research on Centroid Position for Stairs Climbing Stability of Search and Rescue Robot

    Directory of Open Access Journals (Sweden)

    Yan Guo

    2011-01-01

    Full Text Available This paper represents the relationship between the stability of stairs climbing and the centroid position of the search and rescue robot. The robot system is considered as a mass point-plane model and the kinematics features are analyzed to find the relationship between centroid position and the maximal pitch angle of stairs the robot could climb up. A computable function about this relationship is given in this paper. During the stairs climbing, there is a maximal stability-keeping angle depends on the centroid position and the pitch angle of stairs, and the numerical formula is developed about the relationship between the maximal stability-keeping angle and the centroid position and pitch angle of stairs. The experiment demonstrates the trustworthy and correction of the method in the paper.

  19. FACILITATING THE 3D INDOOR SEARCH AND RESCUE PROBLEM: AN OVERVIEW OF THE PROBLEM AND AN ANT COLONY SOLUTION APPROACH

    OpenAIRE

    H. Tashakkori; A. Rajabifard; M. Kalantari

    2016-01-01

    Search and rescue procedures for indoor environments are quite complicated due to the fact that much of the indoor information is unavailable to rescuers before physical entrance to the incident scene. Thus, decision making regarding the number of crew required and the way they should be dispatched in the building considering the various access points and complexities in the buildings in order to cover the search area in minimum time is dependent on prior knowledge and experience of the emerg...

  20. Strategic Reality and Tactical Mirages: Special Operations and the Iranian Hostage Rescue, 1979-1980

    Science.gov (United States)

    2017-06-01

    STRATEGIC REALITY & TACTICAL MIRAGES: SPECIAL OPERATIONS & THE IRANIAN HOSTAGE RESCUE, 1979-1980 BY MARK L. HAMILTON...remaining significant observations, such as technological capabilities,3 are not applicable to this thesis which focuses on decision making by government...not surviving the post–Vietnam drawdown.”9 While the Air Force reduced special operations personnel and equipment, the Army’s response was mixed

  1. CMSMAP : oil, chemical, search and rescue, and marine emergency response crisis management system

    International Nuclear Information System (INIS)

    Anderson, E.L.; Howlett, E.; Galagan, C.; Giguere, T.; Wee, F.; Chong, J.

    2002-01-01

    This paper describes a newly developed Crisis Management System (CMS) which makes it possible to view oil and chemical spills on the seafloor. The CMS is designed to run in a network environment, so that multiple stations can be used cooperatively to respond to a spill incident. It was developed by the Maritime and Port Authority in Singapore and represents a singular integration of a ship's bridge simulator hardware and software. It incorporates numerical models and emergency response software. The CMS is installed in a specifically designed building at the Singapore Polytechnic University, and is integrated with two shipping bridge simulators. One user interface has access to models dealing with oil spills, chemical spills, search and rescues, marine emergencies, and nuclear disasters. The interface is linked to a response management system. The entire system is used to train response personnel to marine emergencies. The histories and costs of planned response activities are described and logged for reference purposes. Estimates of damages associated with spills can be obtained. Alternative response plans can also be determined. Further research in 2002 will focus on developing real time response. 3 refs., 6 figs

  2. A fault-tolerant small world topology control model in ad hoc networks for search and rescue

    Science.gov (United States)

    Tan, Mian; Fang, Ling; Wu, Yue; Zhang, Bo; Chang, Bowen; Holme, Petter; Zhao, Jing

    2018-02-01

    Due to their self-organized, multi-hop and distributed characteristics, ad hoc networks are useful in search and rescue. Topology control models need to be designed for energy-efficient, robust and fast communication in ad hoc networks. This paper proposes a topology control model which specializes for search and rescue-Compensation Small World-Repeated Game (CSWRG)-which integrates mobility models, constructing small world networks and a game-theoretic approach to the allocation of resources. Simulation results show that our mobility models can enhance the communication performance of the constructed small-world networks. Our strategy, based on repeated game, can suppress selfish behavior and compensate agents that encounter selfish or faulty neighbors. This model could be useful for the design of ad hoc communication networks.

  3. Evaluating maps produced by urban search and rescue robots: Lessons learned from RoboCup

    NARCIS (Netherlands)

    Balaguer, B.; Balakirsky, S.; Carpin, S.; Visser, A.

    2009-01-01

    This paper presents the map evaluation methodology developed for the Virtual Robots Rescue competition held as part of RoboCup. The procedure aims to evaluate the quality of maps produced by multi-robot systems with respect to a number of factors, including usability, exploration, annotation and

  4. Advance of Hazardous Operation Robot and its Application in Special Equipment Accident Rescue

    Science.gov (United States)

    Zeng, Qin-Da; Zhou, Wei; Zheng, Geng-Feng

    A survey of hazardous operation robot is given out in this article. Firstly, the latest researches such as nuclear industry robot, fire-fighting robot and explosive-handling robot are shown. Secondly, existing key technologies and their shortcomings are summarized, including moving mechanism, control system, perceptive technology and power technology. Thirdly, the trend of hazardous operation robot is predicted according to current situation. Finally, characteristics and hazards of special equipment accident, as well as feasibility of hazardous operation robot in the area of special equipment accident rescue are analyzed.

  5. Use of a Parabolic Microphone to Detect Hidden Subjects in Search and Rescue.

    Science.gov (United States)

    Bowditch, Nathaniel L; Searing, Stanley K; Thomas, Jeffrey A; Thompson, Peggy K; Tubis, Jacqueline N; Bowditch, Sylvia P

    2018-03-01

    This study compares a parabolic microphone to unaided hearing in detecting and comprehending hidden callers at ranges of 322 to 2510 m. Eight subjects were placed 322 to 2510 m away from a central listening point. The subjects were concealed, and their calling volume was calibrated. In random order, subjects were asked to call the name of a state for 5 minutes. Listeners with parabolic microphones and others with unaided hearing recorded the direction of the call (detection) and name of the state (comprehension). The parabolic microphone was superior to unaided hearing in both detecting subjects and comprehending their calls, with an effect size (Cohen's d) of 1.58 for detection and 1.55 for comprehension. For each of the 8 hidden subjects, there were 24 detection attempts with the parabolic microphone and 54 to 60 attempts by unaided listeners. At the longer distances (1529-2510 m), the parabolic microphone was better at detecting callers (83% vs 51%; P<0.00001 by χ 2 ) and comprehension (57% vs 12%; P<0.00001). At the shorter distances (322-1190 m), the parabolic microphone offered advantages in detection (100% vs 83%; P=0.000023) and comprehension (86% vs 51%; P<0.00001), although not as pronounced as at the longer distances. Use of a 66-cm (26-inch) parabolic microphone significantly improved detection and comprehension of hidden calling subjects at distances between 322 and 2510 m when compared with unaided hearing. This study supports the use of a parabolic microphone in search and rescue to locate responsive subjects in favorable weather and terrain. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  6. U.S. Coast Guard Addendum to the United States National Search and Rescue Supplement (NSS) to the International Aeronautical and Maritime Search and Rescue Manual (IAMSAR)

    Science.gov (United States)

    2009-09-01

    Oaxaca (7) U.S. Consulates (C) and Consulates General (CG) in Mexico: Ciudad Juarez (CG) Matamoros (C) Nogales (C) Guadalajara (CG) Merida (C) Nuevo...recommendations should always be carefully reviewed for practicality and sensibility . 3 - 7 COMDTINST M16130.2E Section 3.2 Search Planning...in some sensible pattern. The number of corner points will be determined by the number of SLDMBs readily available, and the shape and disposition of

  7. Research on one Bio-inspired Jumping Locomotion Robot for Search and Rescue

    Directory of Open Access Journals (Sweden)

    Dunwen Wei

    2014-10-01

    Full Text Available Jumping locomotion is much more effective than other locomotion means in order to tackle the unstructured and complex environment in research and rescue. Here, a bio-inspired jumping robot with a closed-chain mechanism is proposed to achieve the power amplification during taking-off. Through actuating one variable transmission mechanism to change the transmission ratio, the jumping robot reveals biological characteristics in the phase of posture adjustment when adjusting the height and distance of one jump. The kinematics and dynamics of the simplified jumping mechanism model in one jumping cycle sequence are analysed. A compliant contact model considering nonlinear damping is investigated for jumping performance under different terrain characteristics. The numerical simulation algorithm with regard to solving the dynamical equation is described and simulation results are discussed. Finally, one primary prototype and experiment are described. The experimental results show the distance of jumping in the horizontal direction increases with the increasing gear ratio, while the height of jumping decreases in reverse. The jumping robot can enhance the capability to adapt to unknown cluttered environments, such as those encountered in research and rescue, using this strategy.

  8. Frequency Assignments for HFDF Receivers in a Search and Rescue Network

    Science.gov (United States)

    1990-03-01

    SAR problem where whether or not a signal is detected by RS or HFDF at the various stations is described by probabilities. Daskin assumes the...allows the problem to be formulated with a linear objective function (6:52-53). Daskin also developed a heuristic solution algorithm to solve this...en CM in o CM CM < I Q < - -.~- -^ * . . . ■ . ,■ . :ST.-.r . 5 Frequency Assignments for HFDF Receivers in a Search and

  9. Injuries and illnesses among Federal Emergency Management Agency-certified search-and-recovery and search-and-rescue dogs deployed to Oso, Washington, following the March 22, 2014, State Route 530 landslide.

    Science.gov (United States)

    Gordon, Lori E

    2015-10-15

    To establish types and rates of injuries and illnesses among search-and-recovery and search-and-rescue dogs deployed to Oso, Wash, following the March 22, 2014, State Route 530 landslide. Medical records review and cross-sectional survey. 25 Federal Emergency Management Agency-certified search dogs. On-site medical records and postdeployment laboratory test results were reviewed and an electronic survey was distributed to handlers within 8 days after demobilization. Dogs worked a total of 244 search shifts totaling 2,015 hours. Injuries and illnesses were reported in 21 (84%) dogs. Wounds (abrasions, pad wear, paw pad splits, and lacerations) were the most common injury, with an incidence rate of 28.3 wounds/1,000 hours worked. Dehydration was the most common illness, with an incidence rate of 10.4 cases of dehydration/1,000 hours worked. Total incidence rate for all health events was 66.5 events/1,000 hours worked. Two search dogs were removed from search operations for 2 days because of health issues. All others continued search operations while receiving treatment for their medical issues. All health issues were resolved during the deployment or within 2 weeks after demobilization. Results revealed that search dogs deployed to the Oso, Wash, landslide incurred injuries and illnesses similar to those reported following other disasters (dehydration, wounding, vomiting, and diarrhea) but also incurred medical issues not previously documented (acute caudal myopathy, cutaneous mass ruptures, and fever). The reported medical issues were minor; however, prompt veterinary care helped prevent them from developing into more serious conditions.

  10. Information-Fusion Methods Based Simultaneous Localization and Mapping for Robot Adapting to Search and Rescue Postdisaster Environments

    Directory of Open Access Journals (Sweden)

    Hongling Wang

    2018-01-01

    Full Text Available The first application of utilizing unique information-fusion SLAM (IF-SLAM methods is developed for mobile robots performing simultaneous localization and mapping (SLAM adapting to search and rescue (SAR environments in this paper. Several fusion approaches, parallel measurements filtering, exploration trajectories fusing, and combination sensors’ measurements and mobile robots’ trajectories, are proposed. The novel integration particle filter (IPF and optimal improved EKF (IEKF algorithms are derived for information-fusion systems to perform SLAM task in SAR scenarios. The information-fusion architecture consists of multirobots and multisensors (MAM; multiple robots mount on-board laser range finder (LRF sensors, localization sonars, gyro odometry, Kinect-sensor, RGB-D camera, and other proprioceptive sensors. This information-fusion SLAM (IF-SLAM is compared with conventional methods, which indicates that fusion trajectory is more consistent with estimated trajectories and real observation trajectories. The simulations and experiments of SLAM process are conducted in both cluttered indoor environment and outdoor collapsed unstructured scenario, and experimental results validate the effectiveness of the proposed information-fusion methods in improving SLAM performances adapting to SAR scenarios.

  11. Establishing and Maintaining Trust for an Airborne Network. Search and Rescue Enterprise: Security Assessment Report

    Science.gov (United States)

    2014-12-01

    person in distress  IA05 ‐  Yacht  operator  Yacht  operator may be motivated to do mischief, abuse the emergency equipment, or be  motivated to do harm to...distress  Human Malicious Internal Limited  Capability  ThrS2.1 ‐ Mischievous  yacht  operator  Yacht  operator may be motivated to do mischief, abuse the...by mistake  Victim is the operator of the  yacht  in distress, a crew member,  or one of the passengers on board.  Human Non‐malicious External  Limited

  12. Anatomy of a Rescue: What Makes Hostage Rescue Operations Successful?

    National Research Council Canada - National Science Library

    Perez, Carlos

    2004-01-01

    ...: surprise, intelligence, operator's skill, and deception. These principles are derived from planning models used in special operations, personal experience, and an analysis of six historical case studies...

  13. [Design and application of portable rescue vehicle].

    Science.gov (United States)

    Guo, Ying; Qi, Huaying; Wang, Shen

    2017-12-01

    The disease of critically ill patients was with rapid changes, and at any time faced the risk of emergency. The current commonly used rescue vehicles were larger and bulky implementation, which were not conducive to the operation, therefore the design of a portable rescue vehicle was needed. This new type of rescue vehicle is multi-layer folding structure, with small footprint, large storage space, so a variety of first aid things can be classified and put, easy to be cleaned and disinfected. In the rescue process, the portable rescue vehicles can be placed in the required position; box of various emergency items can be found at a glance with easy access; the height of the infusion stand can adjust freely according to the user height; the rescue vehicle handle can be easy to pull and adjust accord with human body mechanics principle. The portable rescue vehicle facilitates the operation of medical staff, and is worthy of clinical application.

  14. Analysis of search and rescue emergency evaluation in ship accidents in Indonesia

    Directory of Open Access Journals (Sweden)

    Arleiny

    2018-01-01

    Full Text Available The objectives og this research is to describe the factors causing ship accident in Indonesia and know the effectiveness of SAR emergency in ship accident in Indonesia. The research method used in this research is qualitative research. Techniques Collection of literature study data and documents. Data validity method using triangulation. Data analysis uses interactive data analysis. The conclusions of this study are Factors that cause the occurrence of ship accidents in Indonesia, among others, the resources of the crew, the eligibility of ships, supporting facilities for shipping, operators, lack of supervision of apparatus, service users and other factors. The high number of ship accidents in Indonesia shows the ineffective implementation of SAR in ship accident in Indonesia.

  15. A novel cooperative localization algorithm using enhanced particle filter technique in maritime search and rescue wireless sensor network.

    Science.gov (United States)

    Wu, Huafeng; Mei, Xiaojun; Chen, Xinqiang; Li, Junjun; Wang, Jun; Mohapatra, Prasant

    2018-07-01

    Maritime search and rescue (MSR) play a significant role in Safety of Life at Sea (SOLAS). However, it suffers from scenarios that the measurement information is inaccurate due to wave shadow effect when utilizing wireless Sensor Network (WSN) technology in MSR. In this paper, we develop a Novel Cooperative Localization Algorithm (NCLA) in MSR by using an enhanced particle filter method to reduce measurement errors on observation model caused by wave shadow effect. First, we take into account the mobility of nodes at sea to develop a motion model-Lagrangian model. Furthermore, we introduce both state model and observation model to constitute a system model for particle filter (PF). To address the impact of the wave shadow effect on the observation model, we develop an optimal parameter derived by Kullback-Leibler divergence (KLD) to mitigate the error. After the optimal parameter is acquired, an improved likelihood function is presented. Finally, the estimated position is acquired. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

  16. Autogenic Feedback Training Exercise and pilot performance: enhanced functioning under search-and-rescue flying conditions

    Science.gov (United States)

    Cowings, P. S.; Kellar, M. A.; Folen, R. A.; Toscano, W. B.; Burge, J. D.

    2001-01-01

    Studies have shown that autonomous mode behavior is one cause of aircraft fatalities due to pilot error. In such cases, the pilot is in a high state of psychological and physiological arousal and tends to focus on one problem, while ignoring more critical information. This study examined the effect of training in physiological self-recognition and regulation, as a means of improving crew cockpit performance. Seventeen pilots were assigned to the treatment and control groups matched for accumulated flight hours. The treatment group contained 4 pilots from HC-130 Hercules aircraft and 4 HH-65 Dolphin helicopter pilots; the control group contained 3 pilots of HC-130s and 6 helicopter pilots. During an initial flight, physiological data were recorded on each crewmember and an instructor pilot rated individual crew performance. Eight crewmembers were then taught to regulate their own physiological response levels using Autogenic-Feedback Training Exercise (AFTE). The remaining participants received no training. During a second flight, treatment participants showed significant improvement in performance (rated by the same instructor pilot as in pretests) while controls did not improve. The results indicate that AFTE management of high states of physiological arousal may improve pilot performance during emergency flying conditions.

  17. Self-Rappelling Robot System for Inspection and Reconnaissance in Search and Rescue Applications

    Science.gov (United States)

    2009-07-01

    improvement over a coarse- treaded tire in the front. This is most likely due to the equivalent diameter of these to the wheel and the fact that the...tethering platforms [10][11], with articulated frame/suspension and reconfigurable running-gear (wheels, legs, treads ) [7], has the potential to overcome...Radius 5.1 [cm] - MAX Outside Jacket Material Polyurethane - 0.064 [cm] thick - Orange Color Tensile Member Material Woven Kevlar Yarn Conductors 3 pairs

  18. In vitro embryo rescue and plant regeneration following self ...

    African Journals Online (AJOL)

    In vitro embryo rescue and plant regeneration following self-pollination with irradiated ... AFRICAN JOURNALS ONLINE (AJOL) · Journals · Advanced Search ... shows that pollen irradiation coupled with self-pollination and embryo rescue ...

  19. On Predicting the Person-in-Water Drift for Search and Rescue

    Science.gov (United States)

    1993-01-01

    and Broida, 1974 Morgan, et al 1977; Morgan 1975, Scobie and Thompson, 1979; Osmer, Edwards and Breitler, 1982; Nash and Willcox 1985). Leeway is...Rubber Rafts’, Woods Hole Oceanographic Institution, 26 pp. Scobie , R.W. and Thompson, D.L., 1979, ."Life Raft Study", Department of Transportation

  20. Integration of Multiple Unmanned Systems in an Urban Search and Rescue Environment

    Science.gov (United States)

    2013-03-01

    urban population is increasing four times as fast as its rural population, and it is undergoing the largest wave of urban growth in history . By 2030...cmd” then press “Enter.” Type ipconfig and check the IPv4 Address. Enter the specific URI into the model in the URI entry as shown in the picture...Enter.” Type ipconfig and check the IPv4 Address. Enter the specific URI into the model in the URI entry as shown in the picture above. (Ensure

  1. Optimal Alignment of Search and Rescue Response Posture with Historical Incident Occurrence

    Science.gov (United States)

    2014-04-01

    and Development Canada Scientific Report DRDC-RDDC-2014-R12 April 2014 © Her Majesty the Queen in Right of Canada, as represented by the Minister of...makers and was used as input to the 2014 CJOC SAR Directive. This report also documents the optimization of RP30 schedules in the Victoria and Halifax...de SAR 2014 du COIC. Ce rapport décrit également l’optimisation des horaires liés à la posture d’intervention de 30 minutes dans les RRS de Victoria et

  2. Integrating Unmanned Aerial Vehicles (UAVs) With Current Combat Search and Rescue (CSAR) Doctrine

    National Research Council Canada - National Science Library

    Altieri, Jayson

    2003-01-01

    .... BACH-21 whipped his plane over into a left SAM break. As G-forces began to press against him, he felt his aircraft shake violently and continued to roll inverted as an SA-6 slammed into his right wing...

  3. Cooperative Search and Rescue with Artificial Fishes Based on Fish-Swarm Algorithm for Underwater Wireless Sensor Networks

    Science.gov (United States)

    Zhao, Wei; Tang, Zhenmin; Yang, Yuwang; Wang, Lei; Lan, Shaohua

    2014-01-01

    This paper presents a searching control approach for cooperating mobile sensor networks. We use a density function to represent the frequency of distress signals issued by victims. The mobile nodes' moving in mission space is similar to the behaviors of fish-swarm in water. So, we take the mobile node as artificial fish node and define its operations by a probabilistic model over a limited range. A fish-swarm based algorithm is designed requiring local information at each fish node and maximizing the joint detection probabilities of distress signals. Optimization of formation is also considered for the searching control approach and is optimized by fish-swarm algorithm. Simulation results include two schemes: preset route and random walks, and it is showed that the control scheme has adaptive and effective properties. PMID:24741341

  4. Cooperative Search and Rescue with Artificial Fishes Based on Fish-Swarm Algorithm for Underwater Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Wei Zhao

    2014-01-01

    Full Text Available This paper presents a searching control approach for cooperating mobile sensor networks. We use a density function to represent the frequency of distress signals issued by victims. The mobile nodes’ moving in mission space is similar to the behaviors of fish-swarm in water. So, we take the mobile node as artificial fish node and define its operations by a probabilistic model over a limited range. A fish-swarm based algorithm is designed requiring local information at each fish node and maximizing the joint detection probabilities of distress signals. Optimization of formation is also considered for the searching control approach and is optimized by fish-swarm algorithm. Simulation results include two schemes: preset route and random walks, and it is showed that the control scheme has adaptive and effective properties.

  5. Microtubule catastrophe and rescue.

    Science.gov (United States)

    Gardner, Melissa K; Zanic, Marija; Howard, Jonathon

    2013-02-01

    Microtubules are long cylindrical polymers composed of tubulin subunits. In cells, microtubules play an essential role in architecture and motility. For example, microtubules give shape to cells, serve as intracellular transport tracks, and act as key elements in important cellular structures such as axonemes and mitotic spindles. To accomplish these varied functions, networks of microtubules in cells are very dynamic, continuously remodeling through stochastic length fluctuations at the ends of individual microtubules. The dynamic behavior at the end of an individual microtubule is termed 'dynamic instability'. This behavior manifests itself by periods of persistent microtubule growth interrupted by occasional switching to rapid shrinkage (called microtubule 'catastrophe'), and then by switching back from shrinkage to growth (called microtubule 'rescue'). In this review, we summarize recent findings which provide new insights into the mechanisms of microtubule catastrophe and rescue, and discuss the impact of these findings in regards to the role of microtubule dynamics inside of cells. Copyright © 2012 Elsevier Ltd. All rights reserved.

  6. Survival at Sea for Mariners, Aviators and Search and Rescue Personnel (Survie en mer pour les marins, les aviateurs et le personnel de recherche et de sauvetage)

    Science.gov (United States)

    2008-02-01

    of Figures viii List of Tables ix Preface x Technical Course HFM-152 xi Executive Summary and Synthèse ES-1 Chapter 1 – Introduction to the RTO...Survival at Sea for Mariners, Aviators and Search and Rescue Personnel (RTO-AG-HFM-152) Executive Summary This NATO RTO Technical Course on Marine...Lors d’accidents en eau froide, il est fort probable que le choc thermique dû au froid ainsi que l’épuisement à la nage entraînent davantage la

  7. An Investigation of Operational Decision Making in Situ: Incident Command in the U.K. Fire and Rescue Service.

    Science.gov (United States)

    Cohen-Hatton, Sabrina R; Butler, Philip C; Honey, Robert C

    2015-08-01

    The aim of this study was to better understand the nature of decision making at operational incidents in order to inform operational guidance and training. Normative models of decision making have been adopted in the guidance and training for emergency services. In these models, it is assumed that decision makers assess the current situation, formulate plans, and then execute the plans. However, our understanding of how decision making unfolds at operational incidents remains limited. Incident commanders, attending 33 incidents across six U.K. Fire and Rescue Services, were fitted with helmet-mounted cameras, and the resulting video footage was later independently coded and used to prompt participants to provide a running commentary concerning their decisions. The analysis revealed that assessment of the operational situation was most often followed by plan execution rather than plan formulation, and there was little evidence of prospection about the potential consequences of actions. This pattern of results was consistent across different types of incident, characterized by level of risk and time pressure, but was affected by the operational experience of the participants. Decision making did not follow the sequence of phases assumed by normative models and conveyed in current operational guidance but instead was influenced by both reflective and reflexive processes. These results have clear implications for understanding operational decision making as it occurs in situ and suggest a need for future guidance and training to acknowledge the role of reflexive processes. © 2015, Human Factors and Ergonomics Society.

  8. Who is going to rescue the rescuers? Post-traumatic stress disorder among rescue workers operating in Greece during the European refugee crisis.

    Science.gov (United States)

    Sifaki-Pistolla, Dimitra; Chatzea, Vasiliki-Eirini; Vlachaki, Sofia-Aikaterini; Melidoniotis, Evangelos; Pistolla, Georgia

    2017-01-01

    During the European refugee crisis, numerous Greek and international rescue workers are operating in Lesvos, offering search, rescue, and first aid services. Exposure to stressful life events while engaging in this rescue work can result in developing Post-Traumatic Stress Disorder (PTSD). The study aimed to assess the prevalence of PTSD and explore potential differences between different categories of rescuers. A cross-sectional study was conducted among 217 rescue workers. Participants were grouped according to affiliation: "Greek Professionals Rescuers/GPR", "International Professionals Rescuers/IPR" and "Volunteer Rescuers/VR". The PTSD Checklist-Civilian Version (PCL-C) was utilized. All tests were two-tailed (a = 0.05). Mann-Whitney, Kruskal-Wallis, and multivariate logistic regression were performed. Overall probable PTSD prevalence found was 17.1%. Rates varied significantly per rescuer's category; 23.1% in GPR, 11.8% in IPR, and 14.6% in VR (p = 0.02). GPR demonstrated the highest risk compared to IPR and VR (p hours, and handling dead refugees and dead children were also considered major risk factors. Rescue workers providing substantial aid to the refugees and migrants at Lesvos experience significant psychological distress. The present findings indicate the urgent need for targeted interventions. Further studies are needed to address long-term effects of the refugee crisis on rescuers, and explore effective measures to prevent PTSD.

  9. Evaluation of the search and rescue LEEWAY model in the Tyrrhenian Sea: a new point of view

    Directory of Open Access Journals (Sweden)

    A. Di Maio

    2016-08-01

    Channel Regional Model developed in the framework of PON-TESSA (Programma Operativo Nazionale; National Operative Program – TEchnology for the Situational Sea Awareness project. The main objective of the work is to validate a new approach of leeway calculation that relies on a real person in water (PIW event, which occurred in the Tyrrhenian Sea in July 2013. The results show that by assimilating a human body to a cylinder and estimating both the transition from laminar to turbulent boundary layer and the drag coefficients, it can be possible to solve a force balance equation, which allows the search area to be estimated with good approximation. This new point of view leads to the possibility of also testing the same approach for other different categories of targets, so as to overcome the limitations associated with the calculation of the leeway in the future by means of standard statistical law.

  10. Cold-water immersion and iced-slush ingestion are effective at cooling firefighters following a simulated search and rescue task in a hot environment.

    Science.gov (United States)

    Walker, Anthony; Driller, Matthew; Brearley, Matt; Argus, Christos; Rattray, Ben

    2014-10-01

    Firefighters are exposed to hot environments, which results in elevated core temperatures. Rapidly reducing core temperatures will likely increase safety as firefighters are redeployed to subsequent operational tasks. This study investigated the effectiveness of cold-water immersion (CWI) and iced-slush ingestion (SLUSH) to cool firefighters post-incident. Seventy-four Australian firefighters (mean ± SD age: 38.9 ± 9.0 years) undertook a simulated search and rescue task in a heat chamber (105 ± 5 °C). Testing involved two 20-min work cycles separated by a 10-min rest period. Ambient temperature during recovery periods was 19.3 ± 2.7 °C. Participants were randomly assigned one of three 15-min cooling protocols: (i) CWI, 15 °C to umbilicus; (ii) SLUSH, 7 g·kg(-1) body weight; or (iii) seated rest (CONT). Core temperature and strength were measured pre- and postsimulation and directly after cooling. Mean temperatures for all groups reached 38.9 ± 0.9 °C at the conclusion of the second work task. Both CWI and SLUSH delivered cooling rates in excess of CONT (0.093 and 0.092 compared with 0.058 °C·min(-1)) and reduced temperatures to baseline measurements within the 15-min cooling period. Grip strength was not negatively impacted by either SLUSH or CONT. CWI and SLUSH provide evidence-based alternatives to passive recovery and forearm immersion protocols currently adopted by many fire services. To maximise the likelihood of adoption, we recommend SLUSH ingestion as a practical and effective cooling strategy for post-incident cooling of firefighters in temperate regions.

  11. Sex, Deportation and Rescue

    DEFF Research Database (Denmark)

    Plambech, Sine

    2017-01-01

    recirculating the claim that human trafficking is the “third largest” criminal economy after drugs and weapons. Based on ethnographic fieldwork among Nigerian sex worker migrants conducted in Benin City, Nigeria, in 2011 and 2012, this study brings together four otherwise isolated migration economies......This contribution explores the economies interlinked by the migration of Nigerian women sex workers. The literature and politics of sex work migration and human trafficking economies are commonly relegated to the realm that focuses on profits for criminal networks and pimps, in particular...... – facilitation, remittances, deportation, and rescueand suggests that we have to examine multiple sites and relink these in order to more fully understand the complexity of sex work migration. Drawing upon literature within transnational feminist analysis, critical human trafficking studies, and migration...

  12. 007 to the Rescue – Cognitive Fit of Operations Research and Agent-based Decision Support

    NARCIS (Netherlands)

    Krauth, Elfriede I.; van Hillegersberg, Jos; van de Velde, Steef L.

    2007-01-01

    Adoption rates of traditional Operations Research (OR) based decision support systems (DSS) suffer from perceived complexity of the underlying model and its detrimental effect on user-friendliness. The mental effort required to understand abstract models can hinder adoption. This barrier may seem

  13. The epidemiology of operations performed by the National Sea Rescue Institute of South Africa over a 5-year period.

    Science.gov (United States)

    Erasmus, Elaine; Robertson, Cleeve; van Hoving, Daniel Jacobus

    2018-01-01

    Injuries remain a major contributor of morbidity and mortality worldwide, with drowning accounting for 7% of all injury-related deaths with rates of between 4 and 8 per 100,000. The African region has death rates comparable to most low-income countries. Non-fatal drowning in Africa remains unquantified but it is estimated to be ten times higher than the fatal drowning rate. Timely search and rescue, initial resuscitation and rapid transportation to definitive care play a crucial role in preventing injury- related morbidity and mortality. The National Sea Rescue Institute (NSRI) of South Africa is a non-profit organisation responsible for ~97% of maritime search and rescue operations in South Africa (including inland navigable waters). The aim of the study was to describe the epidemiology of operations performed by the NSRI of South Africa over a 5-year period. The NSRI operational database was analysed from 1 January 2010 to 31 December 2014. Summary statistics are presented. The NSRI launched 3281 operations over the study period. Marked seasonal variation were noticeable with peak periods in December and January, corresponding to the South African summer holiday season. Water-based operations (67.6%) were the most frequent operation performed. The NSRI assisted 3399 individuals of which 77% were male. The mean age of rescued persons was 42 years. Eight hundred and thirty-six (25%) individuals had non-fatal injuries or illnesses requiring medical assistance. Medical emergencies (35%), traumatic injuries (32.8%), and non-fatal drownings (23%) were the most common types of injury and illness. The majority of the 184 (18%) deaths recorded were due to drowning (75%). Injury and illness, specifically drowning utilise a large proportion of search and rescue services. The results suggest further preventative measures and public health strategies be implemented to minimise traumatic and medical incident severity and subsequent casualties at sea.

  14. Searching for hidden radioactive sources in the Barents Rescue 2001 nuclear emergency exercise

    International Nuclear Information System (INIS)

    Smethurst, Mark A.; Mogaard, John O.; Mauring, Eirik; Koziel, Janusz; Kihle, Ola

    2001-11-01

    The international nuclear emergency exercise Barents Rescue took place in the vicinity of Boden in northern Sweden between the 12th and 20th of September 2001. The Gamma Search Cell part of the exercise was designed to test the abilities of car-borne and airborne measuring systems to quickly locate and characterise radioactive sources hidden in the countryside. The Geological Survey of Norway participated in the Gamma Search Cell with a car-borne gamma-ray spectrometer system, a field team of three persons and a remote support group of two persons situated in Trondheim. The Geological Survey of Norway team identified 16 sources and 2 small areas of Chernobyl fallout in real time. Two additional sources were identified during post processing of the data. Otherwise the team drove past 2 ''strong'' and 4 weak sources without detecting them. The remaining 9 sources were in locations not visited by the car-borne measuring system. All but two source identifications were reported to the base of operations within a few minutes of discovery. The Geological Survey of Norway's source search strategy worked well and comparatively few strong sources were overlooked in the short time allocated for searching. The measuring system proved to be extremely reliable, making approximately 140,000 measurements during 8 days of measuring in and around Boden. (author)

  15. Rescue workers and trauma

    DEFF Research Database (Denmark)

    Romano, Eugenia; Elklit, Ask

    2017-01-01

    Introduction: This study investigates which factors had the biggest impact on developing distress in rescue workers who were involved in a firework factory explosion. Method: Four hundred sixty-five rescuers were assessed using items investigating demographic factors, organizational variables, so...

  16. Physiological effects of stress related to helicopter travel in Federal Emergency Management Agency search-and-rescue canines.

    Science.gov (United States)

    Perry, E; Gulson, N; Liu Cross, T-W; Swanson, K S

    2017-01-01

    Working canines are deployed by the Federal Emergency Management Agency (FEMA), as part of a National Disaster Response Plan. Stress associated with helicopter flight and the resulting physical effects on the dog are unknown. Our objective was to test the hypotheses that (1) helicopter travel affects the physiology and faecal microbiota of working canines, but that (2) physiological consequences of helicopter travel will not negatively affect their work performance. A total of nine FEMA canines were loaded onto helicopters and flown for 30 min in July 2015. Rectal temperature, behavioural stress indicators and saliva swabs (for cortisol) were collected at baseline, loading, mid-flight and post-flight. After flight, canines completed a standardised search exercise to monitor work performance. Faecal samples were collected for microbial DNA extraction and Illumina sequencing. All canines were on a standardised diet (CANIDAE ® Grain Free PURE Land ® ) for 3 weeks prior to the study. Visible indicators of stress were observed at loading and at mid-flight and corresponded with an increase ( P  travel did not affect search performance ( P  > 0·05). We found that α- and β-diversity measures of faecal microbiota were not affected ( P  > 0·05). Our data suggest that although helicopter travel may cause physiological changes that have been associated with stress in working dogs, it does not make an impact on their search performance or the stability of faecal microbiota.

  17. Field studies of safety security rescue technologies through training and response activities

    Science.gov (United States)

    Murphy, Robin R.; Stover, Sam

    2006-05-01

    This paper describes the field-oriented philosophy of the Institute for Safety Security Rescue Technology (iSSRT) and summarizes the activities and lessons learned during calendar year 2005 of its two centers: the Center for Robot-Assisted Search and Rescue and the NSF Safety Security Rescue industry/university cooperative research center. In 2005, iSSRT participated in four responses (La Conchita, CA, Mudslides, Hurricane Dennis, Hurricane Katrina, Hurricane Wilma) and conducted three field experiments (NJTF-1, Camp Hurricane, Richmond, MO). The lessons learned covered mobility, operator control units, wireless communications, and general reliability. The work has collectively identified six emerging issues for future work. Based on these studies, a 10-hour, 1 continuing education unit credit course on rescue robotics has been created and is available. Rescue robots and sensors are available for loan upon request.

  18. The effect of leadership charisma, engagement and group belonging on volunteer work performance: AKUT search and rescue association example

    OpenAIRE

    Ebru Caymaz; Fahri Erenel; Burak Gürer

    2013-01-01

    Leadership charisma, has been emphasized in terms of performance improvement by inspiring organization’s values and norms and making employees spend extra effort for oganization’s objectives especially in hospitals and voluntary organizations (Choi, 2006; Etzioni, 1975; Grojean vd., 2004; Pillai ve Meindl, 1998; Shamir vd., 1993; Sims ve Brinkmann, 2002; Yammarino vd., 1993). In previous studies emphasis was usually on the effects of leadership charisma on work performance. Studies in Turkey ...

  19. Does modern helicopter construction reduce noise exposure in helicopter rescue operations?

    Science.gov (United States)

    Küpper, Thomas; Jansing, Paul; Schöffl, Volker; van Der Giet, Simone

    2013-01-01

    During helicopter rescue operations the medical personnel are at high risk for hearing damage by noise exposure. There are two important factors to be taken into account: first, the extreme variability, with some days involving no exposure but other days with extreme exposure; second, the extreme noise levels during work outside the helicopter, e.g. during winch operations. The benefit of modern, less noisier constructions and the consequences for noise protection are still unknown. We estimated the noise exposure of the personnel for different helicopter types used during rescue operations in the Alps and in other regions of the world with special regard to the advanced types like Eurocopter EC 135 to compare the benefit of modern constructions for noise protection with earlier ones. The rescue operations over 1 year of four rescue bases in the Alps (Raron and Zermatt in Switzerland; Landeck and Innsbruck in Austria, n = 2731) were analyzed for duration of rescue operations (noise exposure). Noise levels were measured during rescue operations at defined points inside and outside the different aircraft. The setting is according to the European standard (Richtlinie 2003/10/EG Amtsblatt) and to Class 1 DIN/IEC 651. With both data sets the equivalent noise level L(eq8h) was calculated. For comparison it was assumed that all rescue operations were performed with a specific type of helicopter. Then model calculations for noise exposure by different helicopter types, such as Alouette IIIb, Alouette II 'Lama', Ecureuil AS350, Bell UH1D, Eurocopter EC135, and others were performed. Depending on modern technologies the situation for the personnel has been improved significantly. Nevertheless noise prevention, which includes noise intermissions in spare time, is essential. Medical checks of the crews by occupational medicine (e.g. 'G20' in Germany) are still mandatory.

  20. The New York City Urban Search and Rescue Team (NY-TF1): A Case Study of Interagency Effectiveness

    Science.gov (United States)

    2011-03-01

    INTENTIONALLY LEFT BLANK vii TABLE OF CONTENTS I. INTRODUCTION ... INTRODUCTION Inasmuch as modern terrorist objectives bring a form of warfare into the realm of the emergency services, it is imperative that those services...and collaborative response; in other words, a synergy of the fire service, law enforcement and emergency mangement . Command needs to be unified

  1. Rope rescue in National fire-fighting and rescue system

    OpenAIRE

    SOCHACKI MARIAN

    2008-01-01

    Автор описывает организацию, функционирование и место системы спасения с высоты в Государственной спасательно-гасящей системе.The author describes organization, working and place of rope rescue in National Firefighting and Rescue System (KSRG).

  2. Microtubule Catastrophe and Rescue

    OpenAIRE

    Gardner, Melissa K.; Zanic, Marija; Howard, Jonathon

    2012-01-01

    Microtubules are long cylindrical polymers composed of tubulin subunits. In cells, microtubules play an essential role in architecture and motility. For example, microtubules give shape to cells, serve as intracellular transport tracks, and act as key elements in important cellular structures such as axonemes and mitotic spindles. To accomplish these varied functions, networks of microtubules in cells are very dynamic, continuously remodeling through stochastic length fluctuations at the ends...

  3. Between Rescue and Research

    DEFF Research Database (Denmark)

    Dobat, Andres S.

    2013-01-01

    its inception, and attempts to identify the reasons why this popular hobby never developed into the problem it has become in other parts of the world. The article concludes that the success of the liberal model in Denmark should be seen as the result of a very complex interplay of legislative...

  4. Rescue Manual. Module 6.

    Science.gov (United States)

    Ohio State Univ., Columbus. Instructional Materials Lab.

    This learner manual for rescuers covers the current techniques or practices required in the rescue service. The sixth of 10 modules contains 4 chapters: (1) industrial rescue; (2) rescue from a confined space; (3) extrication from heavy equipment; and (4) rescue operations involving elevators. Key points, an introduction, and conclusion accompany…

  5. Sea Surface Temperature data collected from buoys deployed world-wide in support of the U.S. Coast Guard Office of Search and Rescue (CG-SAR) program from 2004-03-24 to 2016-09-30 (NCEI Accession (0098145) (NCEI Accession 0098145)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NCEI accessions contains Sea Surface Temperature (SST) data collected from buoys deployed in support of the U.S. Coast Guard Office of Search and Rescue...

  6. Water Supply Systems For Aircraft Fire And Rescue Protection

    Science.gov (United States)

    1995-01-01

    This Advisory Circular (AC) provides guidance for the selection : of a water source and standards for the design of a distribution system to : support aircraft rescue and fire fighting (ARFF) service operations on : airports.

  7. NKS/SRV seminar on Barents Rescue 2001 LIVEX. Gamma search cell

    International Nuclear Information System (INIS)

    Ulvsand, T.; Finck, R.R.; Lauritzen, N.

    2002-04-01

    At the seminar, results from the Gamma Search Cell of the Barents Rescue 2001 LIVEX were presented and the performance and experiences of airborne and car-borne teams that took part in the exercise were evaluated. In the Gamma Search Cell, the mobile teams found about 50 % of a large number of radioactive sources hidden within the exercise area. The exercise demonstrated that it is necessary to practise and test equipment under out-door conditions. By which method a source is found is important information in the evaluation of the result. Complementary methods are necessary to find hidden sources. For heavily shielded sources methods based on scattered radiation should be developed. (au)

  8. A space-based public service platform for terrestrial rescue operations

    Science.gov (United States)

    Fleisig, R.; Bernstein, J.; Cramblit, D. C.

    1977-01-01

    The space-based Public Service Platform (PSP) is a multibeam, high-gain communications relay satellite that can provide a variety of functions for a large number of people on earth equipped with extremely small, very low cost transceivers. This paper describes the PSP concept, the rationale used to derive the concept, the criteria for selecting specific communication functions to be performed, and the advantages of performing such functions via satellite. The discussion focuses on the benefits of using a PSP for natural disaster warning; control of attendant rescue/assistance operations; and rescue of people in downed aircraft, aboard sinking ships, lost or injured on land.

  9. Space Rescue

    Science.gov (United States)

    Muratore, John F.

    2007-01-01

    Space Rescue has been a topic of speculation for a wide community of people for decades. Astronauts, aerospace engineers, diplomats, medical and rescue professionals, inventors and science fiction writers have all speculated on this problem. Martin Caidin's 1964 novel Marooned dealt with the problems of rescuing a crew stranded in low earth orbit. Legend at the Johnson Space Center says that Caidin's portrayal of a Russian attempt to save the American crew played a pivotal role in convincing the Russians to join the real joint Apollo-Soyuz mission. Space Rescue has been a staple in science fiction television and movies portrayed in programs such as Star Trek, Stargate-SG1 and Space 1999 and movies such as Mission To Mars and Red Planet. As dramatic and as difficult as rescue appears in fictional accounts, in the real world it has even greater drama and greater difficulty. Space rescue is still in its infancy as a discipline and the purpose of this chapter is to describe the issues associated with space rescue and the work done so far in this field. For the purposes of this chapter, the term space rescue will refer to any system which allows for rescue or escape of personnel from situations which endanger human life in a spaceflight operation. This will span the period from crew ingress prior to flight through crew egress postlanding. For the purposes of this chapter, the term primary system will refer to the spacecraft system that a crew is either attempting to escape from or from which an attempt is being made to rescue the crew.

  10. Organizations of food redistribution and rescue.

    Science.gov (United States)

    Mousa, T Y; Freeland-Graves, J H

    2017-11-01

    Food insecurity affects 13.4% of the USA population, despite the fact that 30-40% of all food is deposited in a landfill. Food rescue nutrition is the process of redistribution of surplus food to the impoverished. The aim of this study is to document the extent of involvement of organizations in food rescue nutrition. In this cross-sectional study, a survey about organizations involved in food rescue nutrition was developed, validated, and then tested. Directors of 100 organizations involved in food rescue nutrition from eight Southwestern States in the USA participated in this research. These organizations provided an average of 2 million kg of food to more than 40,000 clients each month. Food assistance programs had an average of eight workers and 3081 volunteers. In addition to food, these organizations provided other services such as clothing, clinical, and childcare. The agencies encountered several challenges, including lack of resources that resulted in reducing food portions and turning away clients. The extent of involvement of community-based programs in food rescue nutrition was strong in eight Southwestern states in the USA. Organizations involved in food redistribution helped alleviate food insecurity in their clients. Sustainability of these charitable networks was dependent on availability of resources and sufficient volunteers. Health professionals should encourage these organizations by providing support through donations of time, money, and/or food. Copyright © 2017 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

  11. Medical Support for Aircraft Disaster Search and Recovery Operations at Sea: the RSN Experience.

    Science.gov (United States)

    Teo, Kok Ann Colin; Chong, Tse Feng Gabriel; Liow, Min Han Lincoln; Tang, Kong Choong

    2016-06-01

    The maritime environment presents a unique set of challenges to search and recovery (SAR) operations. There is a paucity of information available to guide provision of medical support for SAR operations for aircraft disasters at sea. The Republic of Singapore Navy (RSN) took part in two such SAR operations in 2014 which showcased the value of a military organization in these operations. Key considerations in medical support for similar operations include the resultant casualty profile and challenges specific to the maritime environment, such as large distances of area of operations from land, variable sea states, and space limitations. Medical support planning can be approached using well-established disaster management life cycle phases of preparedness, mitigation, response, and recovery, which all are described in detail. This includes key areas of dedicated training and exercises, force protection, availability of air assets and chamber support, psychological care, and the forensic handling of human remains. Relevant lessons learned by RSN from the Air Asia QZ8501 search operation are also included in the description of these key areas. Teo KAC , Chong TFG , Liow MHL , Tang KC . Medical support for aircraft disaster search and recovery operations at sea: the RSN experience. Prehosp Disaster Med. 2016; 31(3):294-299.

  12. Search Parameter Optimization for Discrete, Bayesian, and Continuous Search Algorithms

    Science.gov (United States)

    2017-09-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS SEARCH PARAMETER OPTIMIZATION FOR DISCRETE , BAYESIAN, AND CONTINUOUS SEARCH ALGORITHMS by...to 09-22-2017 4. TITLE AND SUBTITLE SEARCH PARAMETER OPTIMIZATION FOR DISCRETE , BAYESIAN, AND CON- TINUOUS SEARCH ALGORITHMS 5. FUNDING NUMBERS 6...simple search and rescue acts to prosecuting aerial/surface/submersible targets on mission. This research looks at varying the known discrete and

  13. Failure to Rescue, Rescue Surgery and Centralization of Postoperative Complications: A Challenge for General and Acute Care Surgeons.

    Science.gov (United States)

    Zago, Mauro; Bozzo, Samantha; Carrara, Giulia; Mariani, Diego

    2017-01-01

    To explore the current literature on the failure to rescue and rescue surgery concepts, to identify the key items for decreasing the failure to rescue rate and improve outcome, to verify if there is a rationale for centralization of patients suffering postoperative complications. There is a growing awareness about the need to assess and measure the failure to rescue rate, on institutional, regional and national basis. Many factors affect failure to rescue, and all should be individually analyzed and considered. Rescue surgery is one of these factors. Rescue surgery assumes an acute care surgery background. Measurement of failure to rescue rate should become a standard for quality improvement programs. Implementation of all clinical and organizational items involved is the key for better outcomes. Preparedness for rescue surgery is a main pillar in this process. Centralization of management, audit, and communication are important as much as patient centralization. Celsius.

  14. Methodological aspects of the use of materials from remote photographs in oil and gas search operations

    Energy Technology Data Exchange (ETDEWEB)

    Kostryukov, M I; Tsarenko, P T

    1981-01-01

    Presented are the methodological characteristics of the use of materials from remote probes in oil and gas search operations within the central part of the western Siberian plain. Examined briefly are ways to increase the effectiveness of interpreting deep structures and the necessity for an amplification in the development of automated systems for interpretation is show.

  15. Neurotrauma and the rule of rescue.

    Science.gov (United States)

    Honeybul, S; Gillett, G R; Ho, K M; Lind, C R P

    2011-12-01

    The rule of rescue describes the powerful human proclivity to rescue identified endangered lives, regardless of cost or risk. Deciding whether or not to perform a decompressive craniectomy as a life-saving or 'rescue' procedure for a young person with a severe traumatic brain injury provides a good example of the ethical tensions that occur in these situations. Unfortunately, there comes a point when the primary brain injury is so severe that if the patient survives they are likely to remain severely disabled and fully dependent. The health resource implications of this outcome are significant. By using a web-based outcome prediction model this study compares the long-term outcome and designation of two groups of patients. One group had a very severe injury as adjudged by the model and the other group a less severe injury. At 18 month follow-up there were significant differences in outcome and healthcare requirements. This raises important ethical issues when considering life-saving but non-restorative surgical intervention. The discussion about realistic outcome cannot be dichotomised into simply life or death so that the outcome for the patient must enter the equation. As in other 'rescue situations', the utility of the procedure cannot be rationalised on a mere cost-benefit analysis. A compromise has to be reached to determine at what point either the likely outcome would be unacceptable to the person on whom the procedure is being performed or the social utility gained from the rule of rescue intervention fails to justify the utilitarian value and justice of equitable resource allocation.

  16. Cost-Benefit Analysis of Marine Corps Search and Rescue (SAR): A Study of Alternatives for Marine Corps Air Stations at Cherry Point and Yuma

    Science.gov (United States)

    2013-11-21

    8999 8999 CAREER PLANNER E5 4821 4821 AVN SAFETY/STAND DIR SAFETY/STAND O4 7551 0000 AVN SAF OFF O3 7596 0000 NATOPS OFF (C-9) O4 7551 0000...NATOPS OFF (UC-35) O4 7554 0000 NATOPS OFF (H-46) O3 7562 0000 AVN OPERATIONS CLERK E4 7041 0000 S-1 ADMIN OFFICER O4 7551 0000 ADMIN OFFICER O4 7551...ASST OPS OFF O4 7562 7562 ASST OPS OFFICER O4 7506 0000 SCHED OFF O3 7562 7562 AVN OPERATIONS CHIEF E7 7041 7041 AVN OPERATIONS CLERK E4 7041

  17. A Stem Cell-rescue Operation in a Nuclear Devastation

    Directory of Open Access Journals (Sweden)

    Editorial

    2011-01-01

    Full Text Available Dear friends, The aftermath of one of the most devastating post earthquake- tsunamis in the history of mankind, the March 2011 post-earthquake-tsunami-hitnuclear accident in Fukushima, Japan, has brought to fore several questions throughout the world on the safety of nuclearinstallations. Such Calamities,which are far beyond our comprehension, has left all nations with such installations and those planning to expand their nuclear power plant programmes in a dilemma. However, the recent news that the Japanese authorities are considering to harvest and store bone marrow stem cells for transfusion to radiation-exposed workers has ushered in a new ray of hope. The hematopoietic stem cells will be harvested before exposure and in case of bone marrow depletion after radiation exposure; these cells can be immediately retrieved from storage and transfused to the radiation-exposed worker so that they have the potential to re-constitute the entire bone marrow in the patient. This will be a great life-saver and game-changer as bone marrow depletion is one of the major consequences of high levels of radiation exposure. This strategy can be prescribed as a routine procedure in all the countries with such nuclear installations, especially for workers at very high risk of radiation exposure. In future, such preventive strategies should be considered for implementation to not only the workers in the facility, but also the rescue team and the vulnerable population in the radiation zone.The regenerative potential of hematopoietic stem cell (HSC is the key factor to be considered now. This is high time that the studies on optimal in vitro expansion of HSCs and ways of successful engraftment of the transfused cells to a niche of radiation-exposed host environment should be attempted in all earnestness by the regenerative medicine community at present. Natural calamities like this help man to realise that the millions of scientific discoveries and inventions can

  18. Theoretical and Empirical Analyses of an Improved Harmony Search Algorithm Based on Differential Mutation Operator

    Directory of Open Access Journals (Sweden)

    Longquan Yong

    2012-01-01

    Full Text Available Harmony search (HS method is an emerging metaheuristic optimization algorithm. In this paper, an improved harmony search method based on differential mutation operator (IHSDE is proposed to deal with the optimization problems. Since the population diversity plays an important role in the behavior of evolution algorithm, the aim of this paper is to calculate the expected population mean and variance of IHSDE from theoretical viewpoint. Numerical results, compared with the HSDE, NGHS, show that the IHSDE method has good convergence property over a test-suite of well-known benchmark functions.

  19. 14 CFR 139.315 - Aircraft rescue and firefighting: Index determination.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Aircraft rescue and firefighting: Index... CERTIFICATION OF AIRPORTS Operations § 139.315 Aircraft rescue and firefighting: Index determination. (a) An index is required by paragraph (c) of this section for each certificate holder. The Index is determined...

  20. SERVARE VITAS- Political Consequences for Romanian National Government and Military of Hostage Deaths in a Romanian Special Operations Forces Hostage Rescue Operation

    National Research Council Canada - National Science Library

    Rapanu, Adrian

    2006-01-01

    ... enforcement and military are immature. This paper attempts to shed light upon the current crisis management procedures and how that arrangement can affect the effectiveness of the state response in hostage situation crises both in country and abroad...

  1. The Search for a Permanent Home: Explaining the Organizational Instability of Air Force Rescue

    Science.gov (United States)

    2015-06-01

    over the last three decades, reflected by multiple relocations within various major commands. The ongoing flux has negatively impacted Rescue’s...of three specialties, the PJ (Pararescueman), Combat Rescue Officer, and Survival, Escape, Resistance and Evasion (SERE) specialists. In this context...Doppler navigation equipment, map display, terrain following/terrain avoidance radar (TF/ TA ) and a Forward Looking Infrared Sensor (FLIR).12 The

  2. SERVARE-VITAS political consequences for Romanian national government and military of hostage deaths in a Romanian Special Operations Forces hostage rescue operation

    OpenAIRE

    Rapanu, Adrian.

    2006-01-01

    Humankind conflicts reached a point where the use of terrorism continues to be viewed as an acceptable and valuable instrument to pursue political goals. Because of the fact that the Romanian forces have encountered little action in the terrorism arena, one can say that the Romanian counter-terrorism and antiterrorism arrangements within the law enforcement and military are immature. This paper attempts to shed light upon the current crisis management procedures and how that arrangement...

  3. SERVARE VITAS- Political Consequences for Romanian National Government and Military of Hostage Deaths in a Romanian Special Operations Forces Hostage Rescue Operation

    Science.gov (United States)

    2006-09-01

    leader, Victor Polay Campos , imprisoning him in Canto Grande prison in Lima. However, in July 1990, Campos and forty-six other MRTA members managed...leadership of MRTA had been captured, including Victor Polay Campos and some of his most important lieutenants. In 1996, the Peruvian government...Fortunately, those altercations ended when the police set up the twelve loudspeakers, with the loud music and patriotic hymns that covered the noises

  4. Tethered Balloon Technology in Design Solutions for Rescue and Relief Team Emergency Communication Services.

    Science.gov (United States)

    Alsamhi, Saeed Hamood; Ansari, Mohd Samar; Ma, Ou; Almalki, Faris; Gupta, Sachin Kumar

    2018-05-23

    The actions taken at the initial times of a disaster are critical. Catastrophe occurs because of terrorist acts or natural hazards which have the potential to disrupt the infrastructure of wireless communication networks. Therefore, essential emergency functions such as search, rescue, and recovery operations during a catastrophic event will be disabled. We propose tethered balloon technology to provide efficient emergency communication services and reduce casualty mortality and morbidity for disaster recovery. The tethered balloon is an actively developed research area and a simple solution to support the performance, facilities, and services of emergency medical communication. The most critical requirement for rescue and relief teams is having a higher quality of communication services which enables them to save people's lives. Using our proposed technology, it has been reported that the performance of rescue and relief teams significantly improved. OPNET Modeler 14.5 is used for a network simulated with the help of ad hoc tools (Disaster Med Public Health Preparedness. 2018;page 1 of 8).

  5. Choking Prevention and Rescue Tips

    Science.gov (United States)

    ... work, in homes and communities, and on the road through leadership, research, education and advocacy. Donate to our cause . The National Safety Council is a nonprofit, 501(c)(3) organization. © ...

  6. Anatomy of a Hostage Rescue: What Makes Hostage Rescue Operations Successful?

    Science.gov (United States)

    2004-09-01

    p. 5). Terrorists are usually motivated by religion or other ideology, and if they die pursuing their cause, they become martyrs and heaven waits...Lecciones de Este Siglo : El Liderazgo en el Comando; “Rescate de la Vida”. Lima, Peru: Servicio Jurídico del Ejercito. Instituto Académico de Derecho

  7. Survival at Sea for Mariners, Aviators and Search and Rescue Personnel (Survie en mer pour les marins, les aviateurs et le personnel de recherche et de sauvetage)

    National Research Council Canada - National Science Library

    2008-01-01

    .... The text discusses key issues such as drowning through cold shock and swimming failure induced by immersion in water particularly below 15 deg C, survival prediction curves and non-freezing cold injuries...

  8. Stress of Rescue Team Members Working in Confined Spaces During a Disaster : Effectiveness of Individual Wireless Communication Devices

    OpenAIRE

    Kitabayashi, Tsukasa; Kudo, Seiko; Kitajima, Maiko; Takamaki, Shizuka; Chiba, Tomohiro; Tachioka, Nobuaki; Kudo, Shungetsu; Kudo, Hiromi

    2016-01-01

    This study evaluated stress experienced by rescue team members during a simulated search and rescue operation in a confined space and determine if wireless communication reduces stress. A total of 57 rescue team members of X prefecture participated. The stress visualization indices were ptyalin (i.e., salivary amylase), salivary cortisol, autonomic nervous system response, visual analog scale, and a short version of the profile of mood states. The subjects were randomized to perform a simulat...

  9. Rip current related drowning deaths and rescues in Australia 2004-2011

    Science.gov (United States)

    Brighton, B.; Sherker, S.; Brander, R.; Thompson, M.; Bradstreet, A.

    2013-04-01

    Rip currents are a common hazard to beachgoers found on many beaches around the world, but it has proven difficult to accurately quantify the actual number of rip current related drowning deaths in many regions and countries. Consequently, reported estimates of rip current drowning can fluctuate considerably and are often based on anecdotal evidence. This study aims to quantify the incidence of rip current related drowning deaths and rescues in Australia from 2004 to 2011. A retrospective search was undertaken for fatal and non-fatal rip-related drowning incidents from Australia's National Coronial Information System (NCIS), Surf Life Saving Australia's (SLSA, 2005-2011) SurfGuard Incident Report Database (IRD), and Media Monitors for the period 1 July 2004 to 30 June 2011. In this time, rip currents were recorded as a factor in 142 fatalities of a total of 613 coastal drowning deaths (23.2%), an average of 21 per year. Rip currents were related to 44% of all beach-related drowning deaths and were involved in 57.4% of reported major rescues in Australian locations where rips occur. A comparison with international operational statistics over the same time period describes rip-related rescues as 53.7% of the total rescues in the US, 57.9% in the UK and 49.4% in New Zealand. The range 49-58% is much lower than 80-89% traditionally cited. The results reported are likely to underestimate the size of the rip current hazard, because we are limited by the completeness of data on rip-related events; however this is the most comprehensive estimate to date. Beach safety practitioners need improved data collection and standardized definitions across organisations. The collection of drowning data using consistent categories and the routine collection of rip current information will allow for more accurate global comparisons.

  10. Environmental modeling to support Elizio Leao ship rescue operation; Modelagem atmosferica e hidrodinamica em apoio a operacao de resgate da embarcacao Elizio Leao

    Energy Technology Data Exchange (ETDEWEB)

    Torres Junior, Audalio R. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Lab. de Modelagem de Processos Marinhos e Atmosfericos (LAMMA); Silva, Mariana P.R.; Silva, Ricardo M. da; Assad, Luiz Paulo de F.; Decco, Hatsue T. de; Landau, Luiz [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Lab. de Metodos Computacinais em Engenharia (LAMCE); Silva Junior, Ronaldo da [PETROBRAS, Rio de Janeiro, RJ (Brazil)

    2008-07-01

    On October 7th, 2007, the Elizio Leao ship broke carrying 19,812.9 gallons of oil near the Marajo Island has mobilized the PIATAM Mar (Potenciais Impactos do Transporte de Petroleo e Derivados na Zona Costeira Amazonica) modeling team for an execution of hydrodynamic and atmospheric prognostics that could support the ship rescue operation. In this work some results are presented as the operational methodology which has been applied to support the rescue team's needs. (author)

  11. Marine Search, Rescue and Emergency Preparedness Study.

    Science.gov (United States)

    1975-09-01

    most points made by these men is that from the Manager of J. Percy Priest Reservoir, William Redmon, who is also a member of the Board of Directors of...Alamo Lake: COE - Lowell C. Flannery Curacanti: National Park Svc. - J. C. Riggs, Chief Park RangerI Jackson : Mancos Water Conservance District...Safety ! J. Percy Priest Reservoir: COE - William G. Redmon, Reservoir Mgr. John Sevier Steam Plant: TA - Walter C. Vance, Lt. Public Safety Kentucky Lake

  12. CO{sub 2} in underground openings and mine rescue training

    Energy Technology Data Exchange (ETDEWEB)

    Weyer, J. [Freiburg Univ. of Mining and Technology (Germany). Inst. of Mining Engineering and Special Civil Engineering

    2010-07-01

    Mine rescue training procedures related to dangerous gases in mines were discussed. Methods of detecting carbon dioxide (CO{sub 2}) in abandoned opening and old adits were presented. High concentrations of CO{sub 2} combine with hemoglobin and lead to a lack of oxygen supply to the inner organs. Nitric acid forms in the alveoli and can lead to injuries or death after a period of 4 to 12 hours. Exposure to very high concentrations of CO{sub 2} can cause people to immediately lose consciousness. CO{sub 2} concentrations in the blood can change pH blood values. Members of mine rescue teams should be equipped with breathing equipment and be between 18 and 40 years old. Training rescue operations should be conducted 4 times per year. While larger mines have their own rescue teams, smaller mines must ensure that guest rescue teams are familiar with their mines. Various mine training activities were reviewed. 5 refs.

  13. Clinical and economic analysis of rescue intracytoplasmic sperm injection cycles.

    Science.gov (United States)

    Shalom-paz, Einat; Alshalati, Jana; Shehata, Fady; Jimenez, Luis; Son, Weon-Young; Holzer, Hananel; Tan, Seang Lin; Almog, Benny

    2011-12-01

    To identify clinical and embryological factors that may predict success in rescue intracytoplasmic sperm injection (ICSI) cycles (after total fertilization failure has occurred) and to evaluate the cost effectiveness of rescue ICSI strategy. Additionally, follow-up of 20 rescue ICSI pregnancies is reported. Retrospective analysis of total fertilization failure cycles. University-based tertiary medical center. In total, 92 patients who had undergone conventional in-vitro fertilization (IVF) cycles with total fertilization failure were included. The patients were divided into two subgroups: those who conceived through rescue ICSI and those who did not. The pregnant members of the rescue ICSI subgroup were found to be significantly younger (32.9 ± 4.2 vs. 36.3 ± 4.5, respectively, p = 0.0035,) and to have better-quality embryos than those who did not conceive (cumulative embryo score: 38.3 ± 20.4 vs. 29.3 ± 14.7, p = 0.025). Cost effectiveness analysis showed 25% reduction in the cost per live birth when rescue ICSI is compared to cycle cancellation approach. The pregnancies follow-up did not show adverse perinatal outcome. Rescue ICSI is an option for salvaging IVF cycles complicated by total fertilization failure. Success in rescue ICSI was found to be associated with younger age and higher quality of embryos. Furthermore, the cost effectiveness of rescue ICSI in terms of total fertilization failure was found to be worthwhile.

  14. Rescue and Fire Fighting on RWY 06R/24L

    Directory of Open Access Journals (Sweden)

    Kristýna Vaňková

    2016-04-01

    Full Text Available Rescue and firefighting service is an important and essential part at the Václav Havel Airport Prague and it has to follow the requirements stated in Commission regulations (EU, regulations and laws of Czech Republic. Construction of parallel runway 06R/24L influences runway and taxiway system significantly. Consequences of these construction changes are changes of access routes and new places of potential interventions originates. Safety risks of inaccessible areas at the airport and inability to follow response time come with operations of the new runway. These risks are assessed and mitigated if necessary.

  15. The Development Of Indonesias Doctrine for Special Hostage Rescue Operations

    Science.gov (United States)

    2015-12-01

    in humanitarian, military, economic , diplomatic and political arenas. Therefore, NEOs involve the swift insertion of a force, temporary occupation...trained and equipped military and paramilitary forces to achieve military, political, economic , or psychological objectives by unconventional...an inbound pirate’s boat heading towards the ship. The crew fought to hinder the pirates from boarding the vessel. However, the pirates were able to

  16. Development of Future Rule Curves for Multipurpose Reservoir Operation Using Conditional Genetic and Tabu Search Algorithms

    Directory of Open Access Journals (Sweden)

    Anongrit Kangrang

    2018-01-01

    Full Text Available Optimal rule curves are necessary guidelines in the reservoir operation that have been used to assess performance of any reservoir to satisfy water supply, irrigation, industrial, hydropower, and environmental conservation requirements. This study applied the conditional genetic algorithm (CGA and the conditional tabu search algorithm (CTSA technique to connect with the reservoir simulation model in order to search optimal reservoir rule curves. The Ubolrat Reservoir located in the northeast region of Thailand was an illustrative application including historic monthly inflow, future inflow generated by the SWAT hydrological model using 50-year future climate data from the PRECIS regional climate model in case of B2 emission scenario by IPCC SRES, water demand, hydrologic data, and physical reservoir data. The future and synthetic inflow data of reservoirs were used to simulate reservoir system for evaluating water situation. The situations of water shortage and excess water were shown in terms of frequency magnitude and duration. The results have shown that the optimal rule curves from CGA and CTSA connected with the simulation model can mitigate drought and flood situations than the existing rule curves. The optimal future rule curves were more suitable for future situations than the other rule curves.

  17. Embryo rescue of crosses between diploid and tetraploid grape ...

    African Journals Online (AJOL)

    ajl yemi

    2011-12-19

    Dec 19, 2011 ... embryo rescue from interspecific hybridization between diploid and tetraploid grape species. Wakana et al. (2003) and Motosugi et al. (2003) studied the formation and developments of hybrid seeds from cross between diploid and tetraploid, and then obtained triploid progenies through embryo rescue.

  18. Review and expectations of terror attack emergency rescue

    Directory of Open Access Journals (Sweden)

    De-wen WANG

    2012-03-01

    Full Text Available Ten years of anti-terror struggle since the 9/11 event has indicated adequately that terrorism is a global problem and international danger. Likewise, anti-terror emergency rescue is also an important task which will influence the safety and benefit of every country all over the world. This paper reviews the main progress and result of international anti-terror struggle in the last ten years, and also introduces the new characteristic of the international anti-terror activity. Besides that, this paper also brings forward the further consideration about the anti-terror emergency medical rescue and the researches remaining to be carried out. The latter includes: (1 to further perfect the high-efficient medical rescue command organization; (2 to further perfect the emergency medical rescue prearranged scheme; (3 to further perfect the construction of rescue system and rescue base after various types of terror attack; (4 to further promote the anti-terror consciousness in the public, and pay more attention to the prevention and investigation of the psychological disaster; (5 to further carry out the basic investigation on emergency medical rescue after various terror attack injuries (for example the types and characteristics of new injuries, pathophysiology and prevention and treatment of stress-psychological effect induced by terror attack, new high-efficient medical rescue measure and equipments, and so on.

  19. 29 CFR 553.215 - Ambulance and rescue service employees.

    Science.gov (United States)

    2010-07-01

    ... activities, the applicable standard is the one which applies to the activity in which the employee spends the majority of work time during the work period. (b) Ambulance and rescue service employees of public agencies... 29 Labor 3 2010-07-01 2010-07-01 false Ambulance and rescue service employees. 553.215 Section 553...

  20. Observing the Loss of Situational Awareness and Tacit Knowledge during Personnel Change-Over in a U.S. Coast Guard Command and Control Environment

    Science.gov (United States)

    2012-09-01

    After Bellinger et al. 2004) ..............22  Figure 7.  SECI model (From Nonaka and Konno 1998) ................................................25...Operational Unit – Search and Rescue controller RCC Rescue Coordination Center SAR Search and Rescue SECI Socialization, Externalization, Combination, and...combination of tacitness and explicitness make it possible to conceptualize four conversion patterns. Taken from Nonaka’s and Knono’s (1998) SECI model

  1. Medical rescue of naval combat: challenges and future.

    Science.gov (United States)

    Jin, Hai; Hou, Li-Jun; Fu, Xiao-Bing

    2015-01-01

    There has been no large-scale naval combat in the last 30 years. With the rapid development of battleships, weapons manufacturing and electronic technology, naval combat will present some new characteristics. Additionally, naval combat is facing unprecedented challenges. In this paper, we discuss the topic of medical rescue at sea: what challenges we face and what we could do. The contents discussed in this paper contain battlefield self-aid buddy care, clinical skills, organized health services, medical training and future medical research programs. We also discuss the characteristics of modern naval combat, medical rescue challenges, medical treatment highlights and future developments of medical rescue at sea.

  2. Rescuing Rover: A First Aid and Disaster Guide for Dog Owners

    OpenAIRE

    Heath, Sebastian E.

    1998-01-01

    Whether you're hiking with your canine friend in a remote area or work with a dog on a search-and-rescue team or police force, you need to be prepared for emergencies when veterinary service is not available. Rescuing Rover: A First Aid and Disaster Guide for Dog Owners provides dog owners, handlers, and emergency physicians with an understandable guide for safe treatment until the dog can be transported to a veterinarian. Although a number of books describe some techniques for the emergency ...

  3. [Advanced online search techniques and dedicated search engines for physicians].

    Science.gov (United States)

    Nahum, Yoav

    2008-02-01

    In recent years search engines have become an essential tool in the work of physicians. This article will review advanced search techniques from the world of information specialists, as well as some advanced search engine operators that may help physicians improve their online search capabilities, and maximize the yield of their searches. This article also reviews popular dedicated scientific and biomedical literature search engines.

  4. Geometric Models for Collaborative Search and Filtering

    Science.gov (United States)

    Bitton, Ephrat

    2011-01-01

    This dissertation explores the use of geometric and graphical models for a variety of information search and filtering applications. These models serve to provide an intuitive understanding of the problem domains and as well as computational efficiencies to our solution approaches. We begin by considering a search and rescue scenario where both…

  5. The Cognitive Dissonance between Child Rescue and Child Protection

    NARCIS (Netherlands)

    K.E. Cheney (Kristen)

    2015-01-01

    textabstract‘Saving orphans’ has become an industry that irrevocably harms children and undermines the development of child welfare systems. We must replace the drive to rescue with the desire to protect.

  6. EPS insulated façade fires from a fire and rescue perspective

    Directory of Open Access Journals (Sweden)

    Kumm M.

    2013-11-01

    Full Text Available This paper highlights the challenges the fire and rescue services can meet at façade fires involving EPS insulation during construction and use of a building. The EPS characteristics are discussed in respect to the fire and rescue operation and results from orientating fire tests performed at a fire and rescue services training and test field are presented. Types of evacuation solutions, involving the fire and rescue services, where façade fires can delay or completely rule out the possibilities for safe evacuation, are presented. The restrictions in the Swedish building codes regarding use of combustible insulation are analysed and reflections over the practical problems with following the instructions to keep an EPS insulated façade safe through the building's whole lifespan are made. A number of occurred fires involving EPS are discussed and analysed from a fire and rescue perspective. Finally, recommendations are given for the fire and rescue services and future research fields are proposed.

  7. USCGC Dallas Med/Black Sea Deployment: Regional Engagement and USCG-USN Interoperability

    National Research Council Canada - National Science Library

    Kohout, Richard

    1996-01-01

    COMSIXTHFLT received several requests from littoral nations for training and interaction in maritime law enforcement, maritime interception, search and rescue, fisheries protection, and other coastal patrol operations...

  8. 46 CFR 199.175 - Survival craft and rescue boat equipment.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Survival craft and rescue boat equipment. 199.175....175 Survival craft and rescue boat equipment. (a) All lifeboat and rescue boat equipment— (1) Must be... craft or rescue boat; or (iii) Overload the launching appliance. (b) Each lifeboat, rigid liferaft, and...

  9. Emergency Preparedness and Role Clarity among Rescue Workers during the Terror Attacks in Norway July 22, 2011.

    Directory of Open Access Journals (Sweden)

    May Janne Botha Pedersen

    Full Text Available Few studies address preparedness and role clarity in rescue workers after a disaster. On July 22, 2011, Norway was struck by two terror attacks; 77 people were killed and many injured. Healthcare providers, police officers and firefighters worked under demanding conditions. The aims of this study were to examine the level of preparedness, exposure and role clarity. In addition, the relationship between demographic variables, preparedness and exposure and a role clarity during the rescue operations and; b achieved mastering for future disaster operations.In this cross-sectional study, healthcare providers (n = 859, police officers (n = 252 and firefighters (n = 102 returned a questionnaire approximately 10 months after the terror attacks.The rescue personnel were trained and experienced, and the majority knew their professional role (healthcare providers M = 4.1 vs. police officers: M = 3.9 vs. firefighters: M = 4.2, p 5 fatalities (OR 1.6, p < .05 were all associated with role clarity, together with a feeling of control, not being obstructed in work and perceiving the rescue work as a success. Moreover, independent predictors of being more prepared for future operations were arousal during the operation (OR 2.0, p < .001 and perceiving the rescue work as a success (OR 1.5, p < .001.Most of the rescue workers were experienced and knew their professional role. Training and everyday-work-experience must be a focal point when preparing rescue workers for disaster.

  10. Cooperative mobile agents search using beehive partitioned structure and Tabu Random search algorithm

    Science.gov (United States)

    Ramazani, Saba; Jackson, Delvin L.; Selmic, Rastko R.

    2013-05-01

    In search and surveillance operations, deploying a team of mobile agents provides a robust solution that has multiple advantages over using a single agent in efficiency and minimizing exploration time. This paper addresses the challenge of identifying a target in a given environment when using a team of mobile agents by proposing a novel method of mapping and movement of agent teams in a cooperative manner. The approach consists of two parts. First, the region is partitioned into a hexagonal beehive structure in order to provide equidistant movements in every direction and to allow for more natural and flexible environment mapping. Additionally, in search environments that are partitioned into hexagons, mobile agents have an efficient travel path while performing searches due to this partitioning approach. Second, we use a team of mobile agents that move in a cooperative manner and utilize the Tabu Random algorithm to search for the target. Due to the ever-increasing use of robotics and Unmanned Aerial Vehicle (UAV) platforms, the field of cooperative multi-agent search has developed many applications recently that would benefit from the use of the approach presented in this work, including: search and rescue operations, surveillance, data collection, and border patrol. In this paper, the increased efficiency of the Tabu Random Search algorithm method in combination with hexagonal partitioning is simulated, analyzed, and advantages of this approach are presented and discussed.

  11. Effective operators in SUSY, superfield constraints and searches for a UV completion

    CERN Document Server

    Dudas, E.

    2015-01-01

    We discuss the role of a class of higher dimensional operators in 4D N=1 supersymmetric effective theories. The Lagrangian in such theories is an expansion in momenta below the scale of "new physics" ($\\Lambda$) and contains the effective operators generated by integrating out the "heavy states" above $\\Lambda$ present in the UV complete theory. We go beyond the "traditional" leading order in this momentum expansion (in $\\partial/\\Lambda$). Keeping manifest supersymmetry and using superfield {\\it constraints} we show that the corresponding higher dimensional (derivative) operators in the sectors of chiral, linear and vector superfields of a Lagrangian can be "unfolded" into second-order operators. The "unfolded" formulation has only polynomial interactions and additional massive superfields, some of which are ghost-like if the effective operators were {\\it quadratic} in fields. Using this formulation, the UV theory emerges naturally and fixes the (otherwise unknown) coefficient and sign of the initial (higher...

  12. An application of the MEMbrain training module: Pre-hospital rescue operation

    DEFF Research Database (Denmark)

    Andersen, V.

    1998-01-01

    A system for training in pre-hospital emergency management is being developed and the first version of a prototype has been completed. The training system fulfils the demands from the domain of hospital emergency planning centres and medical attendants concerning increased efficiency of rescue...... efforts. This includes enhanced first aid on site and improved overall co-ordination amongst the organisations involved in coping with emergency situations. The training system is based on the Multi-User System for Training Emergency Response (MUSTER) concept which is used for the training module...

  13. Design and implementation of fishery rescue data mart system

    Science.gov (United States)

    Pan, Jun; Huang, Haiguang; Liu, Yousong

    A novel data mart based system for fishery rescue field was designed and implemented. The system runs ETL process to deal with original data from various databases and data warehouses, and then reorganized the data into the fishery rescue data mart. Next, online analytical processing (OLAP) are carried out and statistical reports are generated automatically. Particularly, quick configuration schemes are designed to configure query dimensions and OLAP data sets. The configuration file will be transformed into statistic interfaces automatically through a wizard-style process. The system provides various forms of reporting files, including crystal reports, flash graphical reports, and two-dimensional data grids. In addition, a wizard style interface was designed to guide users customizing inquiry processes, making it possible for nontechnical staffs to access customized reports. Characterized by quick configuration, safeness and flexibility, the system has been successfully applied in city fishery rescue department.

  14. Rescue US: Birth, Django, and the Violence of Racial Redemption

    Directory of Open Access Journals (Sweden)

    Joseph Winters

    2018-01-01

    Full Text Available In this article, I show how the relationship between race, violence, and redemption is articulated and visualized through film. By juxtaposing DW Griffith’s The Birth of a Nation and Quentin Tarantino’s Django Unchained, I contend that the latter inverts the logic of the former. While Birth sacrifices black bodies and explains away anti-black violence for the sake of restoring white sovereignty (or rescuing the nation from threatening forms of blackness, Django adopts a rescue narrative in order to show the excessive violence that structured slavery and the emergence of the nation-state. As an immanent break within the rescue narrative, Tarantino’s film works to “rescue” images and sounds of anguish from forgetful versions of history.

  15. Genetic Information, the Principle of Rescue, and Special Obligations.

    Science.gov (United States)

    Liao, S Matthew; Mackenzie, Jordan

    2018-05-01

    In "Genetic Privacy, Disease Prevention, and the Principle of Rescue," Madison Kilbride argues that patients have a duty to warn biological family members about clinically actionable adverse genetic findings. The duty does not stem from the special obligations that we may have to family members, she argues, but rather follows from the principle of rescue, which she understands as the idea that one ought to prevent, reduce, or mitigate the risk of harm to another person when the expected harm is serious and the cost or risk to oneself is sufficiently moderate. We doubt, however, whether the principle of rescue can ground a duty to warn in the cases Kilbride envisages, and we suggest that Kilbride may have underappreciated the role that special obligations could play in generating a duty to warn family members. © 2018 The Hastings Center.

  16. Translocation and radiotelemetry monitoring of black-tailed marmosets, Callithrix (Mico melanura(É. Geoffroy in Humboldt, in a wildlife rescue operation in Brazil

    Directory of Open Access Journals (Sweden)

    AAB. Marques

    Full Text Available Five black-tailed marmoset Callithrix (Mico melanura (Primates - Callitrichidae individuals were monitored by radiotelemetry as part of a project on translocated wildlife affected by flooding the Manso River reservoir in the state of Mato Grosso, western Brazil (14° 52' S and 55° 48' W. The animals were monitored for eight months from October 2000 through August 2001. Only one death was recorded among the translocated animals. Two pairs established their home ranges in the new area, after some exploratory behavior. The new home range sizes varied from 0.72 to 4.27 km². The home ranges of male and female overlapped in the case of both pairs by 0.59 to 2.30 km². Trips were always made in pairs and not individually. The results indicate the feasibility of a successful translocation program for this species, as long as the animals are translocated to a similar habitat nearby.

  17. Protecting front-line survey and rescue teams during emergencies

    International Nuclear Information System (INIS)

    Tresise, H.

    1980-01-01

    Means of protecting front-line survey and rescue teams during emergencies are described. The team composition, their apparatus, the selection of the incident control point, the use of guidelines and breathing apparatus and control point trolley and equipment are discussed. (H.K.)

  18. EMERGENCY VICTIM CARE AND RESCUE, TEXTBOOK FOR SQUADMEN.

    Science.gov (United States)

    Ohio State Dept. of Education, Columbus. Trade and Industrial Education Service.

    DESIGNED FOR TRAINING EMERGENCY SQUAD PERSONNEL IN RESCUE PROCEDURES AND VICTIM CARE BEYOND BASIC FIRST AID, THIS TEXTBOOK WAS DEVELOPED BY A COMMITTEE OF SQUADMEN, DOCTORS, NURSES, FIREMEN, AND STATE TRADE AND INDUSTRIAL PERSONNEL TO BE USED IN ADULT TRAINING CLASSES OF FULL-TIME OR VOLUNTEER SQUADMEN. THE INSTRUCTIONAL MATERIAL INCLUDES 26…

  19. Review of the rescue, rehabilitation and restoration of oiled seabirds ...

    African Journals Online (AJOL)

    Review of the rescue, rehabilitation and restoration of oiled seabirds in South Africa, especially African penguins Spheniscus demersus and Cape gannets Morus capensis , 1983–2005. ... In addition, oiling has a long-term negative impact on the breeding productivity and cost of reproduction in de-oiled birds. The primary ...

  20. Embryo rescue of crosses between diploid and tetraploid grape ...

    African Journals Online (AJOL)

    ajl yemi

    2011-12-19

    Dec 19, 2011 ... Five cross combinations Jumeigui×Xinghua No.1, 87-1×Kyoho, Kyoho×Muscat Hamburg, Jumeigui×. Hongqitezao and Red globle×Kyoho were used as the testing materials. Factors that affect embryo rescue from crossed seeds between diploid and tetraploid grape were studied applying L25(55).

  1. Embryo rescue of crosses between diploid and tetraploid grape ...

    African Journals Online (AJOL)

    Five cross combinations Jumeigui×Xinghua No.1, 87-1×Kyoho, Kyoho×Muscat Hamburg, Jumeigui× Hongqitezao and Red globle×Kyoho were used as the testing materials. Factors that affect embryo rescue from crossed seeds between diploid and tetraploid grape were studied applying L25(55) orthogonal experiment ...

  2. In vitro embryo rescue and plant regeneration following self ...

    African Journals Online (AJOL)

    EJIRO

    2015-07-08

    Jul 8, 2015 ... 2Department of Biological Sciences, College of Natural Sciences, Makerere ... Key words: Cassava, doubled haploids, embryo rescue, plant regeneration, pollen germination, pollen ... breeding as inbred lines are readily tested and used within a ... dominance, allowing the separation of homozygotes from.

  3. RoboCup Rescue Robot and Simulation Leagues

    NARCIS (Netherlands)

    Akin, H.L.; Ito, N.; Jacoff, A.; Kleiner, A.; Pellenz, J.; Visser, A.

    2013-01-01

    The RoboCup Rescue Robot and Simulation competitions have been held since 2000. The experience gained during these competitions has increased the maturity level of the field, which allowed deploying robots after real disasters (for example, Fukushima Daiichi nuclear disaster). This article provides

  4. Rescuing Israeli travellers: effects of substance abuse, mental health, geographic region of rescue, gender and age of rescuees.

    Science.gov (United States)

    Bonny-Noach, Hagit; Sagiv-Alayoff, Moran

    2017-09-01

    Research conducted on young Israeli travellers has pointed to high substance usage rates. For some drug-using backpackers, actual extraction and rescue from their trip abroad is necessary. This study represents a first attempt to explore the influence of geographic region in which rescue occurs, cause for rescue and gender and age differences among Israeli rescuees. Sub-analysis of all logs of individual rescuees during a 5-year period from 2011 to 2016 ( N  = 86) included 66 men and 20 women, with an average age of 27.83 (SD = 7.86). The findings demonstrate that Israelis are most frequently rescued from South and Southeast Asia (57%) followed by Europe (22%), South America (17%), North America (2.3%) and Africa (1.2%). India was the country with the highest rate of rescue incidents ( N  = 36) followed by Thailand ( N  = 8) and the Netherlands ( N  = 5). The most common cause for rescue was substance abuse (87%). However, significant regional differences were found based on the variable of age ( F  = 3.21, df = 3,50, P  young travellers should be taken into consideration when thinking about induced acute psychosis caused by substance use. Policymakers need to consider prevention and harm reduction interventions relevant to this risk group. © International Society of Travel Medicine, 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

  5. The SHERPA project: Smart collaboration between humans and ground-aerial robots for improving rescuing activities in alpine environments

    NARCIS (Netherlands)

    Marconi, L.; Melchiorri, C.; Beetz, M.; Pangercic, D.; Siegwart, R.; Leutenegger, S.; Carloni, Raffaella; Stramigioli, Stefano; Bruyninckx, H.; Doherty, P.; Kleiner, A.; Lippiello, V.; Finzi, A.; Siciliano, B.; Sala, A.; Tomatis, N.

    2012-01-01

    The goal of the paper is to present the foreseen research activity of the European project “SHERPA‿ whose activities will start officially on February 1th 2013. The goal of SHERPA is to develop a mixed ground and aerial robotic platform to support search and rescue activities in a real-world hostile

  6. Operation management of daily economic dispatch using novel hybrid particle swarm optimization and gravitational search algorithm with hybrid mutation strategy

    Science.gov (United States)

    Wang, Yan; Huang, Song; Ji, Zhicheng

    2017-07-01

    This paper presents a hybrid particle swarm optimization and gravitational search algorithm based on hybrid mutation strategy (HGSAPSO-M) to optimize economic dispatch (ED) including distributed generations (DGs) considering market-based energy pricing. A daily ED model was formulated and a hybrid mutation strategy was adopted in HGSAPSO-M. The hybrid mutation strategy includes two mutation operators, chaotic mutation, Gaussian mutation. The proposed algorithm was tested on IEEE-33 bus and results show that the approach is effective for this problem.

  7. 46 CFR 111.75-16 - Lighting of survival craft and rescue boats.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Lighting of survival craft and rescue boats. 111.75-16... craft and rescue boats. (a) During preparation, launching, and recovery, each survival craft and rescue... of circuits must be such that the lighting for adjacent launching stations for survival craft or...

  8. 46 CFR 199.160 - Rescue boat embarkation, launching and recovery arrangements.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Rescue boat embarkation, launching and recovery...) LIFESAVING APPLIANCES AND ARRANGEMENTS LIFESAVING SYSTEMS FOR CERTAIN INSPECTED VESSELS Requirements for All Vessels § 199.160 Rescue boat embarkation, launching and recovery arrangements. (a) Each rescue boat must...

  9. 46 CFR 133.160 - Rescue boat embarkation, launching and recovery arrangements.

    Science.gov (United States)

    2010-10-01

    ...) OFFSHORE SUPPLY VESSELS LIFESAVING SYSTEMS Requirements for All OSVs § 133.160 Rescue boat embarkation, launching and recovery arrangements. (a) Each davit for a rescue boat must be approved under approval series... 46 Shipping 4 2010-10-01 2010-10-01 false Rescue boat embarkation, launching and recovery...

  10. Validation of the Athens Insomnia Scale for screening insomnia in South Korean firefighters and rescue workers.

    Science.gov (United States)

    Jeong, Hyeonseok S; Jeon, Yujin; Ma, Jiyoung; Choi, Yera; Ban, Soonhyun; Lee, Sooyeon; Lee, Bora; Im, Jooyeon Jamie; Yoon, Sujung; Kim, Jieun E; Lim, Jae-Ho; Lyoo, In Kyoon

    2015-10-01

    Sleep problems are a major cause of occupational stress in firefighters and rescue workers. We evaluated the psychometric properties of the Athens Insomnia Scale (AIS) among South Korean firefighters and rescue workers. Structured clinical interviews and self-report questionnaires were administered to 221 firefighters and rescue workers. The Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), Short-Form 36-item Health Survey (SF36), and Alcohol Use Disorder Identification Test-Consumption (AUDIT-C) were used to examine convergent and divergent validity. Test-retest reliability was calculated from a subsample (n = 24). Analysis of internal consistency, factor analysis, and receiver operator characteristic curve analysis were conducted. Cronbach's alpha was 0.88. The mean item-total correlation coefficient was 0.73. The test-retest reliability was excellent (ICC = 0.94). Significant correlations of the AIS with the PSQI, ISI, ESS, and SF36 confirmed convergent validity. Nonsignificant associations of the AIS with the AUDIT-C and socioeconomic status showed divergent validity. Factor analysis revealed a one-factor structure. For groups with different symptom severity, group-specific cutoff scores which may improve positive predictive values were suggested. The AIS may be a useful tool with good reliability and validity for screening insomnia symptoms in firefighters and rescue workers.

  11. Evolutionary rescue: linking theory for conservation and medicine.

    Science.gov (United States)

    Alexander, Helen K; Martin, Guillaume; Martin, Oliver Y; Bonhoeffer, Sebastian

    2014-12-01

    Evolutionary responses that rescue populations from extinction when drastic environmental changes occur can be friend or foe. The field of conservation biology is concerned with the survival of species in deteriorating global habitats. In medicine, in contrast, infected patients are treated with chemotherapeutic interventions, but drug resistance can compromise eradication of pathogens. These contrasting biological systems and goals have created two quite separate research communities, despite addressing the same central question of whether populations will decline to extinction or be rescued through evolution. We argue that closer integration of the two fields, especially of theoretical understanding, would yield new insights and accelerate progress on these applied problems. Here, we overview and link mathematical modelling approaches in these fields, suggest specific areas with potential for fruitful exchange, and discuss common ideas and issues for empirical testing and prediction.

  12. Compressing bitmap indexes for faster search operations

    International Nuclear Information System (INIS)

    Wu, Kesheng; Otoo, Ekow J.; Shoshani, Arie

    2002-01-01

    In this paper, we study the effects of compression on bitmap indexes. The main operations on the bitmaps during query processing are bitwise logical operations such as AND, OR, NOT, etc. Using the general purpose compression schemes, such as gzip, the logical operations on the compressed bitmaps are much slower than on the uncompressed bitmaps. Specialized compression schemes, like the byte-aligned bitmap code(BBC), are usually faster in performing logical operations than the general purpose schemes, but in many cases they are still orders of magnitude slower than the uncompressed scheme. To make the compressed bitmap indexes operate more efficiently, we designed a CPU-friendly scheme which we refer to as the word-aligned hybrid code (WAH). Tests on both synthetic and real application data show that the new scheme significantly outperforms well-known compression schemes at a modest increase in storage space. Compared to BBC, a scheme well-known for its operational efficiency, WAH performs logical operations about 12 times faster and uses only 60 percent more space. Compared to the uncompressed scheme, in most test cases WAH is faster while still using less space. We further verified with additional tests that the improvement in logical operation speed translates to similar improvement in query processing speed

  13. Compressing bitmap indexes for faster search operations

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Kesheng; Otoo, Ekow J.; Shoshani, Arie

    2002-04-25

    In this paper, we study the effects of compression on bitmap indexes. The main operations on the bitmaps during query processing are bitwise logical operations such as AND, OR, NOT, etc. Using the general purpose compression schemes, such as gzip, the logical operations on the compressed bitmaps are much slower than on the uncompressed bitmaps. Specialized compression schemes, like the byte-aligned bitmap code(BBC), are usually faster in performing logical operations than the general purpose schemes, but in many cases they are still orders of magnitude slower than the uncompressed scheme. To make the compressed bitmap indexes operate more efficiently, we designed a CPU-friendly scheme which we refer to as the word-aligned hybrid code (WAH). Tests on both synthetic and real application data show that the new scheme significantly outperforms well-known compression schemes at a modest increase in storage space. Compared to BBC, a scheme well-known for its operational efficiency, WAH performs logical operations about 12 times faster and uses only 60 percent more space. Compared to the uncompressed scheme, in most test cases WAH is faster while still using less space. We further verified with additional tests that the improvement in logical operation speed translates to similar improvement in query processing speed.

  14. Medical rescue of naval combat: challenges and future

    OpenAIRE

    Jin, Hai; Hou, Li-Jun; Fu, Xiao-Bing

    2015-01-01

    There has been no large-scale naval combat in the last 30?years. With the rapid development of battleships, weapons manufacturing and electronic technology, naval combat will present some new characteristics. Additionally, naval combat is facing unprecedented challenges. In this paper, we discuss the topic of medical rescue at sea: what challenges we face and what we could do. The contents discussed in this paper contain battlefield self-aid buddy care, clinical skills, organized health servi...

  15. Vulture rescue and rehabilitation in South Africa: An urban perspective

    Directory of Open Access Journals (Sweden)

    V. Naidoo

    2011-04-01

    Full Text Available SouthAfrica is home to 9 vulture species, of which 7 are endangered. While the cause of the population declines remains largely speculative, a vast amount of effort has been dedicated towards the protection of populations by ensuring sustainable and safe food sources for the various colonies. Limited focus was placed in the past on efforts related to the rescue and/or rehabilitation (R&R of injured birds and the release of these birds back into the wild. This paper provides an overview of the causes, the impact and success of 3 organisations involved in R&R efforts of vultures in the Magaliesberg mountain range and surrounding areas over a period of 10 years. Study material included 162 Cape griffon (CGV and 38 African white-backed (AWBV vultures. Datasets include the number, sex and age of birds received, the reason the vultures were brought in for R&R, surgical interventions performed and outcomes of rescue efforts. The CGV dominated the rehabilitation attempts. Results further show that a large number of apparently healthy birds were presented for veterinary treatment. The R&R data clearly indicate that the major cause of injuries was birds colliding with overhead pylons, as a high number of soft tissue and skeletal injuries were observed. The study also shows that successful releases of rescued birds are possible. It is concluded that urbanisation has had a major negative impact on vultures around the Magaliesberg mountain range.

  16. Search for an onset mechanism that operates for both CMEs and substorms

    Directory of Open Access Journals (Sweden)

    G. L. Siscoe

    2009-08-01

    Full Text Available Substorms and coronal mass ejections have been cited as the most accessible examples of the explosive energy conversion phenomenon that seems to characterize one of the behavior modes of cosmic plasmas. This paper addresses the question of whether these two examples – substorms and CMEs – support or otherwise the idea that explosive energy conversion is the result of a single process operating in different places and under different conditions. As a candidate mechanism that might be common to both substorms and CMEs we use the Forbes catastrophe model for CMEs because before testing it appears to have the potential, suitably modified, to operate also for substorms. The essence of the FCM is a sudden onset of an imbalance of the forces acting on an incipient CME. The imbalance of forces causes the CME to start to rise. Beneath the rising CME conditions develop that favor the onset of magnetic reconnection which then releases the CME and assists its expulsion. Thus the signature of the FCM is a temporally ordered sequence in which there is first the appearance of force imbalance which leads to upward (or outward motion of the CME which leads to magnetic reconnection under it which expedites rapid expulsion. We look for the FCM signature in the output of two global magnetospheric MHD simulations that produce substorm-like events. We find the ordered sequence of events as stated but with a significant difference: there is no plasmoid prior to the onset of rapid reconnection, that is, there is no counterpart to the incipient CME on which an imbalance of forces acts to initiate the action in the FCM. If this result – that rapid tailward motion precedes the rapid reconnection of substorm expansion – is ultimately verified by other studies, it suggests that a description of the cause of substorm expansion should identify the cause of the preceding rapid tailward motion, since this leads necessarily to rapid reconnection, whatever the

  17. [New possibilities in emergency medical transportation and emergency services of Polish Medical Air Rescue].

    Science.gov (United States)

    Gałazkowski, Robert

    2010-01-01

    In Poland, two types of medical services are accomplished by the Medical Air Rescue (MAR) operating all over the country: emergency transport from the incident scene to hospital and inter-hospital transport. Helicopters or planes are used for this purpose. In 2009, helicopters performed 4359 flights to incidents and 1537 inter-hospital transports whereas planes performed 589 inter-hospital ambulance and 196 rescue flights. MAR operates from 17 bases of the Helicopter Emergency Medical Service (HEMS) and one airbase. Helicopters are mainly used when medical transport is emergent, within the operational region of a given base whereas planes when the distance between the present and target airports exceeds 250 km. In 2008, new modern aircraft were introduced to HEMS-helicopters EC 135. They fulfil all requirements of air transport regulations and are adjusted to visual (VFR) and instrumental (IFR) flights rules, at day and night. The medical cabin of EC 135 is ergonomic and functional considering the majority of rescue activities under life-saving circumstances. It is equipped with ventilator, defibrillator, infusion pumps etc. Defibrillators have 12-lead ECG, E(T)CO2, SpO2, NIBP, and IBP modules. Transport ventilators can work in a variety of ventilation modes including CMV, SIMV, SVV, BILEVEL, PCV, ASB, PPV and CPAP. The purchase of helicopters with modern avionic and medical configuration ensures high quality services of MAR for many years to come.

  18. Integrated system of occupational safety and health and fire protection of the fire rescue brigades members.

    Science.gov (United States)

    Božović, Marijola; Živković, Snežana; Mihajlović, Emina

    2018-06-01

    The objective of the conducted research is the identification and determination of requirements of members of fire rescue brigades during operations in the conditions of high risk in order to minimize the possibilities for injury incidence during the intervention. The research is focused on examination, determination and identification of factors affecting the increasing number of occupational injuries of members of fire rescue brigades during interventions. Hypothetical framework of the research problem consists of general hypothesis and six special hypotheses. Results suggest that almost all respondents believe that their skills and abilities are applicable in the intervention phase, but less than a half believe that their skills are applicable in prevention phase. Two-thirds of respondents stated that in their organization they have support for further education and upgrading while a half of respondents stated that they need education concerning identification, assessment and management of risks that can lead to emergency situations.

  19. The lived experience of rescuing people who have driven into floodwater: Understanding challenges and identifying areas for providing support.

    Science.gov (United States)

    Keech, Jacob J; Smith, Stephanie R; Peden, Amy E; Hagger, Martin S; Hamilton, Kyra

    2018-06-11

    Drowning is a major public health issue, with risk increasing during times of flood. Driving though floodwater is a major risk factor for flood-related drowning and injury, and despite widespread public health campaigns, many people continue to undertake this risky behaviour and require rescue. We aimed to identify key challenges faced by emergency services personnel when rescuing those who have driven into floodwater, and to identify strategies for supporting rescuers in this important role. Australian flood rescue operators (N=8) who had previously rescued a driver who had driven through floodwater, participated in semi-structured interviews. Data were analysed using thematic analysis. Four challenges emerged from their experiences: Involvement of untrained personnel, varying information provided by emergency telephone operators, behaviour of drivers complicating the rescue, people sightseeing floods or flood rescues, or ignoring closed roads providing sources of distraction and frustration. We propose five strategies for translating these results into practice, including: training and protocol development for (1) emergency personnel and (2) telephone operators, (3) training for rescuers regarding non-compliant rescuees, (4) educating the public, and (5) increasing compliance with closed roads. Current findings provide valuable insights into how rescuers can be supported in performing their roles, and implementation of these strategies has the potential to reduce fatalities occurring due to driving through floodwater. SO WHAT?: The strategies presented have the potential to reduce the frequency and improve the outcomes of floodwater rescues, aiding in the prevention of injury and death. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  20. Enhancing Artificial Bee Colony Algorithm with Self-Adaptive Searching Strategy and Artificial Immune Network Operators for Global Optimization

    Directory of Open Access Journals (Sweden)

    Tinggui Chen

    2014-01-01

    Full Text Available Artificial bee colony (ABC algorithm, inspired by the intelligent foraging behavior of honey bees, was proposed by Karaboga. It has been shown to be superior to some conventional intelligent algorithms such as genetic algorithm (GA, artificial colony optimization (ACO, and particle swarm optimization (PSO. However, the ABC still has some limitations. For example, ABC can easily get trapped in the local optimum when handing in functions that have a narrow curving valley, a high eccentric ellipse, or complex multimodal functions. As a result, we proposed an enhanced ABC algorithm called EABC by introducing self-adaptive searching strategy and artificial immune network operators to improve the exploitation and exploration. The simulation results tested on a suite of unimodal or multimodal benchmark functions illustrate that the EABC algorithm outperforms ACO, PSO, and the basic ABC in most of the experiments.

  1. Design and rescue scenario of common repair equipment for in-vessel components in ITER hot cell

    International Nuclear Information System (INIS)

    Kakudate, Satoshi; Takeda, Nobukazu; Nakahira, Masataka; Shibanuma, Kiyoshi

    2006-06-01

    Transportation of the in-vessel components to be repaired in the ITER hot cell is carried by two kinds of transporters, i.e., overhead cranes and floor vehicles. The access area for repair operations in the hot cell is duplicated by these transporters. Clear sharing of the respective roles of these transporters with the minimum duplication is therefore useful for rationalization. The overhead cranes, which are independently installed in the respective cells in the hot sell, cannot pass through the components to be repaired between cells, i.e., receiving cell and refurbishment cell as an example. If the floor vehicle with simple mechanisms can cover the inaccessible area for the overhead cranes, a global transporter system in the hot cell will be simplified and the reliability will be increased. Based on this strategy, the overhead crane and floor vehicle concepts are newly proposed. The overhead crane has an adapter for change of the end-effectors, which can be easily changed, to grasp many kinds of components to be repaired. The floor vehicle, which is equipped with wheel mechanisms for transportation, is just to pass through the components between cells with only straight (linear) motion on the floor. The simple wheel mechanism can solve the spread of the dust, which is the critical issue of the original air bearing mechanism for traveling in the 2001 FDR design. Rescue scenarios and procedures in the hot cell are also studied in this report. The proposed rescue crane has major two functions for rescue operations of the hot cell facility, i.e., one for the overhead crane and the other for refurbishment equipment such as workstation for divertor repair. The rescue of the faulty overhead crane is carried out using the rescue tool installed on the rescue crane or directly traveled by pushing/pulling by the rescue crane after docking on the faulty overhead crane. For the rescue of the workstation, the rescue crane consists of a telescopic manipulator (maximum length

  2. NATO Advanced Research Institute on Search Theory and Applications

    CERN Document Server

    Stone, Lawrence

    1980-01-01

    The NATO Advanced Research Institute on Search Theory and Appli­ cations was held at the Hotel Algarve in Praia Da Rocha, Portugal, from March 26 through March 30, 1979, and was sponsored by the NATO Special Programme Panel on Systems Science. There were forty-one participants representing a wide range of backgrounds and interests. The purpose of the institute was to bring together people working in search theory and applications with potential users of search techniques to stimulate the increased application of recent­ ly developed search technology to civilian problems such as search and rescue, mineral exploration, surveillance, and fishing. Con­ versely, it was felt that by exposing search analysts to potential applications and new problems, they would be stimulated to develop new techniques for these applications and problems. The exchange of ideas and problems necessary to accomplish these goals was provided in the meeting workshops. There were three workshops, Search and Rescue, Exploration, and Sur...

  3. Incremental artificial bee colony with local search to economic dispatch problem with ramp rate limits and prohibited operating zones

    International Nuclear Information System (INIS)

    Özyön, Serdar; Aydin, Doğan

    2013-01-01

    Highlights: ► Prohibited operating zone economic dispatch problem has been solved by IABC-LS. ► The losses used in the solution of the problem have been computed by B-loss matrix. ► IABC-LS method has been applied to three test systems in literature. ► The values obtained by IABC and IABC-LS are better than the results in literature. - Abstract: In this study, prohibited operating zone economic power dispatch problem which considers ramp rate limit, has been solved by incremental artificial bee colony algorithm (IABC) and incremental artificial bee colony algorithm with local search (IABC-LS) methods. The transmission line losses used in the solution of the problem have been computed by B-loss matrix. IABC, IABC-LS methods have been applied to three different test systems in literature which consist of 6, 15 and 40 generators. The attained optimum solution values have been compared with the optimum results in literature and have been discussed.

  4. Multi-level and Multi-component Bitmap Encoding for Efficient Search Operations

    Directory of Open Access Journals (Sweden)

    Madhu BHAN, Department of Computer Applications

    2012-12-01

    Full Text Available The growing interest in data warehousing for decision makers is becoming more and more crucial to make faster and efficient decisions. On-line decision needs short response times. Many indexing techniques have been created to achieve this goal in read only environments. Indexing technique that has attracted attention in multidimensional databases is Bitmap Indexing. The paper discusses the various existing bitmap indexing techniques along with their performance characteristics. The paper proposes two new bitmap indexing techniques in the class of multi-level and multi-component encoding schemes and prove that the two techniques have better space–time performance than some of the existing techniques used for range queries. We provide an analytical model for comparing the performance of our proposed encoding schemes with that of the existing ones.

  5. Learning to Solve Problems by Searching for Macro-Operators

    Science.gov (United States)

    1983-07-01

    executing generalized robot plans. Aritificial Intelligence 3:25 1-288, 1972. [Frey 821 Frey, Alexander Ii. Jr., and David Singmaster. Handbook of Cubik...and that searching for macros may be a useful general learning paradigm. 1.1. Introduction One view of die die field of artificial intelligence is that... intelligence literature [Schofield 67, Gaschnig 79, Ericsson 761 and provides one of the simplest examples of the operation of the Macro Problem Solver. It

  6. Space rescue system definition (system performance analysis and trades)

    Science.gov (United States)

    Housten, Sam; Elsner, Tim; Redler, Ken; Svendsen, Hal; Wenzel, Sheri

    This paper addresses key technical issues involved in the system definition of the Assured Crew Return Vehicle (ACRV). The perspective on these issues is that of a prospective ACRV contractor, performing system analysis and trade studies. The objective of these analyses and trade studies is to develop the recovery vehicle system concept and top level requirements. The starting point for this work is the definition of the set of design missions for the ACRV. This set of missions encompasses three classes of contingency/emergency (crew illness/injury, space station catastrophe/failure, transportation element catastrophe/failure). The need is to provide a system to return Space Station crew to Earth quickly (less than 24 hours) in response to randomly occurring contingency events over an extended period of time (30 years of planned Space Station life). The main topics addressed and characterized in this paper include the following: Key Recovery (Rescue) Site Access Considerations; Rescue Site Locations and Distribution; Vehicle Cross Range vs Site Access; On-orbit Loiter Capability and Vehicle Design; and Water vs. Land Recovery.

  7. International Fund of Aral Sea rescue:prospects and new aims

    International Nuclear Information System (INIS)

    Aslov, S.M.

    2003-01-01

    In this chapter of book author suggest about aims and prospects of International Fund of Aral Sea rescue. The base aim of International Fund of Aral Sea rescue was the funds attraction of Central Asia governments and international community-donors for financing of Program of Aral Sea basin. Now the Executive Committee of International Fund of Aral Sea rescue develops the program of basin of Aral Sea for the period till 2010

  8. Thermodynamic Data Rescue and Informatics for Deep Carbon Science

    Science.gov (United States)

    Zhong, H.; Ma, X.; Prabhu, A.; Eleish, A.; Pan, F.; Parsons, M. A.; Ghiorso, M. S.; West, P.; Zednik, S.; Erickson, J. S.; Chen, Y.; Wang, H.; Fox, P. A.

    2017-12-01

    A large number of legacy datasets are contained in geoscience literature published between 1930 and 1980 and not expressed external to the publication text in digitized formats. Extracting, organizing, and reusing these "dark" datasets is highly valuable for many within the Earth and planetary science community. As a part of the Deep Carbon Observatory (DCO) data legacy missions, the DCO Data Science Team and Extreme Physics and Chemistry community identified thermodynamic datasets related to carbon, or more specifically datasets about the enthalpy and entropy of chemicals, as a proof of principle analysis. The data science team endeavored to develop a semi-automatic workflow, which includes identifying relevant publications, extracting contained datasets using OCR methods, collaborative reviewing, and registering the datasets via the DCO Data Portal where the 'Linked Data' feature of the data portal provides a mechanism for connecting rescued datasets beyond their individual data sources, to research domains, DCO Communities, and more, making data discovery and retrieval more effective.To date, the team has successfully rescued, deposited and registered additional datasets from publications with thermodynamic sources. These datasets contain 3 main types of data: (1) heat content or enthalpy data determined for a given compound as a function of temperature using high-temperature calorimetry, (2) heat content or enthalpy data determined for a given compound as a function of temperature using adiabatic calorimetry, and (3) direct determination of heat capacity of a compound as a function of temperature using differential scanning calorimetry. The data science team integrated these datasets and delivered a spectrum of data analytics including visualizations, which will lead to a comprehensive characterization of the thermodynamics of carbon and carbon-related materials.

  9. A Multi-purpose Rescue Vehicle and a human–robot interface architecture for remote assistance in ITER

    International Nuclear Information System (INIS)

    Soares, João; Vale, Alberto; Ventura, Rodrigo

    2015-01-01

    Highlights: • Design of an omnidirectional vehicle equipped with cameras and laser range finders. • Two robotic manipulators that slide over the vehicle's body to perform independent tasks. • Architecture to connect the control system, communication, power, navigation and HMI. • An immersive interface HMI with augmented reality features with head mounted display. - Abstract: The remote handling (RH) plays an important role in nuclear test facilities, such as in ITER, for in-vessel and ex-vessel maintenance operations. Unexpected situations may occur when RH devices fail. Since no human being is allowed during the RH operations, a Multi-purpose Rescue Vehicle (MPRV) must be required for providing support in site. This paper proposes a design of a MPRV, i.e., a mobile platform equipped with different sensors and two manipulators with different sets of end-effectors. A human–machine interface is also proposed to remotely operate the MPRV and to carry out rescue and recovery operations.

  10. 46 CFR 199.220 - Survival craft and rescue boat embarkation arrangements.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Survival craft and rescue boat embarkation arrangements... APPLIANCES AND ARRANGEMENTS LIFESAVING SYSTEMS FOR CERTAIN INSPECTED VESSELS Additional Requirements for Passenger Vessels § 199.220 Survival craft and rescue boat embarkation arrangements. (a) Survival craft...

  11. Finding the Sweet Spot for Catastrophic Incident Search and Rescue

    Science.gov (United States)

    2009-09-01

    with SAR assets. Another high-tech SAR structure is found in the Cosmicheskaya Sistema Poiska Avariynyh Sudov56 (COSPAS-SARSAT) system. This model...shows clear 56 COSPAS is an acronym for the Russian, “Cosmicheskaya Sistema Poiska Avariynyh...under each of the preparedness categories. HSPD 5 is the companion document to HSPD 8, which discusses management of domestic incidents (Bush, 2003

  12. Identifying a "default" visual search mode with operant conditioning.

    Science.gov (United States)

    Kawahara, Jun-ichiro

    2010-09-01

    The presence of a singleton in a task-irrelevant domain can impair visual search. This impairment, known as the attentional capture depends on the set of participants. When narrowly searching for a specific feature (the feature search mode), only matching stimuli capture attention. When searching broadly (the singleton detection mode), any oddball captures attention. The present study examined which strategy represents the "default" mode using an operant conditioning approach in which participants were trained, in the absence of explicit instructions, to search for a target in an ambiguous context in which one of two modes was available. The results revealed that participants behaviorally adopted the singleton detection as the default mode but reported using the feature search mode. Conscious strategies did not eliminate capture. These results challenge the view that a conscious set always modulates capture, suggesting that the visual system tends to rely on stimulus salience to deploy attention.

  13. UvA Rescue Technical Report: a description of the methods and algorithms implemented in the UvA Rescue code release

    NARCIS (Netherlands)

    Visser, A.

    2012-01-01

    This technical report gives the background documentation behind the competition code of the UvA Rescue Team, who participates in the RoboCup Simulation League. The described code is used in the Virtual Robot competition, where a team of robots, guided by a single operator, has to find as many

  14. Professional and Regulatory Search

    Science.gov (United States)

    Professional and Regulatory search are designed for people who use EPA web resources to do their job. You will be searching collections where information that is not relevant to Environmental and Regulatory professionals.

  15. In Search of Internationalized Operator Interface Displays in Process Control: A Comparison among Malaysian, Singaporean and Chinese

    National Research Council Canada - National Science Library

    Liang, Sheau-Farn M; Khalid, Halimahtun M; Taha, Zahari; Plocher, Thomas

    2004-01-01

    .... In this study, 266 Malaysian operators from various industrial sites in Malaysia were recruited to answer a computerized questionnaire regarding their perceptions of colors, shapes and orientations...

  16. An Exploratory Analysis of Village Search Operations

    National Research Council Canada - National Science Library

    Aydin, Mehmet

    2004-01-01

    .... The agent-based model MANA (Map Aware Non-uniform Automata) is used to develop the scenarios, and state-of-the-art Near Orthogonal Latin Hypercube Designs are used to investigate the effects of 16 variables...

  17. Postmodernity and a hypertensive patient: rescuing value from nihilism.

    Science.gov (United States)

    Smith, S

    1998-01-01

    Much of postmodern philosophy questions the assumptions of Modernity, that period in the history of the Western world since the Enlightment. These assumptions are that truth is discoverable through human reason; that certain knowledge is possible; and furthermore, that such knowledge will provide a basis for the ineluctable progress of Mankind. The Enlightenment project is underwritten by the conviction that knowledge gained through the scientific method is secure. In so far as biomedicine inherits these assumptions it becomes fair game for postmodern deconstruction. Today, perhaps more than ever, plural values compete, and contradictory approaches to health, for instance, garner support and acquire supremacy through consumer choice and media manipulation rather than evidence-based science. Many doctors feel a tension between meeting the needs of the patient face to face, and working towards the broader health needs of the public at large. But if the very foundations of medical science are questioned, by patients, or by doctors themselves, wherein lies the value of their work? This paper examines the issues that the anti-foundationalist thrust of postmodernism raises, in the light of a case of mild hypertension. The strict application of medical protocol, derived from a nomothetic, statistical perspective, seems unlikely to furnish value in the treatment of an individual. The anything goes, consumerist approach, however, fares no better. The author argues that whilst value cannot depend on any rationally predetermined parameters, it can be rescued, and emerges from the process of the meeting with the patient. PMID:9549679

  18. Safety technology: Emergency equipment and sea rescue techniques

    Energy Technology Data Exchange (ETDEWEB)

    1986-06-01

    In June 1986, a two day workshop was convened to review mobile offshore drilling unit (MODU) evacuation research and development (R D) requirements for programs currently sponsored by the Marine Engineering Committee for PERD (Panel on Energy Research and Development) task 6.2. The proceedings of the workshop are presented in terms of: evacuation technology needs; a review of current R D projects for their relevance to the technological needs; recommended changes to current projects where warranted; and recommended priority R D projects that are not presently being undertaken to meet the evacuation technology needs. Current R D projects reviewed include: preferred orientation and displacement (PROD) lifeboat launching, personal transfer baskets, arctic escape system (AES), fast rescue craft (FRC), helicopter survival suits, diving bell emergency heaters, working immersion suits, diving bell emergency ascent system, undersea robotics systems and DCIEM decompression tables. It was concluded that gaps in offshore safety/evacuation capability cannot be adequately addressed by one or two major projects. Rather, a wider range of problems exist that require attention through a greater financial commitment than is presently the case. Government-industry cooperation in this field is required. Overall, the projects were judged to have been well planned, managed, and relevant to offshore safety needs. The only exception was a feeling that diving related projects consummed a disproportionate share of the available funding. Further, there was some reservation that the robotics study was outside the 6.2 PERD R D mandate. A list of recommendations is presented. 1 tab.

  19. Importance of teamwork, communication and culture on failure-to-rescue in the elderly.

    Science.gov (United States)

    Ghaferi, A A; Dimick, J B

    2016-01-01

    Surgical mortality increases significantly with age. Wide variations in mortality rates across hospitals suggest potential levers for improvement. Failure-to-rescue has been posited as a potential mechanism underlying these differences. A review was undertaken of the literature evaluating surgery, mortality, failure-to-rescue and the elderly. This was followed by a review of ongoing studies and unpublished work aiming to understand better the mechanisms underlying variations in surgical mortality in elderly patients. Multiple hospital macro-system factors, such as nurse staffing, available hospital technology and teaching status, are associated with differences in failure-to-rescue rates. There is emerging literature regarding important micro-system factors associated with failure-to-rescue. These are grouped into three broad categories: hospital resources, attitudes and behaviours. Ongoing work to produce interventions to reduce variations in failure-to-rescue rates include a focus on teamwork, communication and safety culture. Researchers are using novel mixed-methods approaches and theories adapted from organizational studies in high-reliability organizations in an effort to improve the care of elderly surgical patients. Although elderly surgical patients experience failure-to-rescue events at much higher rates than their younger counterparts, patient-level effects do not sufficiently explain these differences. Increased attention to the role of organizational dynamics in hospitals' ability to rescue these high-risk patients will establish high-yield interventions aimed at improving patient safety. © 2015 BJS Society Ltd Published by John Wiley & Sons Ltd.

  20. Reliable Rescue Routing Optimization for Urban Emergency Logistics under Travel Time Uncertainty

    Directory of Open Access Journals (Sweden)

    Qiuping Li

    2018-02-01

    Full Text Available The reliability of rescue routes is critical for urban emergency logistics during disasters. However, studies on reliable rescue routing under stochastic networks are still rare. This paper proposes a multiobjective rescue routing model for urban emergency logistics under travel time reliability. A hybrid metaheuristic integrating ant colony optimization (ACO and tabu search (TS was designed to solve the model. An experiment optimizing rescue routing plans under a real urban storm event, was carried out to validate the proposed model. The experimental results showed how our approach can improve rescue efficiency with high travel time reliability.

  1. Rescue pre-operative treatment with Lugol's solution in uncontrolled Graves' disease.

    Science.gov (United States)

    Calissendorff, Jan; Falhammar, Henrik

    2017-05-01

    Graves' disease is a common cause of hyperthyroidism. Three therapies have been used for decades: pharmacologic therapy, surgery and radioiodine. In case of adverse events, especially agranulocytosis or hepatotoxicity, pre-treatment with Lugol's solution containing iodine/potassium iodide to induce euthyroidism before surgery could be advocated, but this has rarely been reported. All patients hospitalised due to uncontrolled hyperthyroidism at the Karolinska University Hospital 2005-2015 and treated with Lugol's solution were included. All electronic files were carefully reviewed manually, with focus on the cause of treatment and admission, demographic data, and effects of iodine on thyroid hormone levels and pulse frequency. Twenty-seven patients were included. Lugol's solution had been chosen due to agranulocytosis in 9 (33%), hepatotoxicity in 2 (7%), other side effects in 11 (41%) and poor adherence to medication in 5 (19%). Levels of free T4, free T3 and heart rate decreased significantly after 5-9 days of iodine therapy (free T4 53-20 pmol/L, P  = 0.0002; free T3 20-6.5 pmol/L, P  = 0.04; heart rate 87-76 beats/min P  = 0.0007), whereas TSH remained unchanged. Side effects were noted in 4 (15%) (rash n  = 2, rash and vomiting n  = 1, swelling of fingers n  = 1). Thyroidectomy was performed in 26 patients (96%) and one was treated with radioiodine; all treatments were without serious complications. Treatment of uncontrolled hyperthyroidism with Lugol's solution before definitive treatment is safe and it decreases thyroid hormone levels and heart rate. Side effects were limited. Lugol's solution could be recommended pre-operatively in Graves' disease with failed medical treatment, especially if side effects to anti-thyroid drugs have occurred. © 2017 The authors.

  2. Rescue pre-operative treatment with Lugol’s solution in uncontrolled Graves’ disease

    Directory of Open Access Journals (Sweden)

    Jan Calissendorff

    2017-04-01

    Full Text Available Background: Graves’ disease is a common cause of hyperthyroidism. Three therapies have been used for decades: pharmacologic therapy, surgery and radioiodine. In case of adverse events, especially agranulocytosis or hepatotoxicity, pre-treatment with Lugol’s solution containing iodine/potassium iodide to induce euthyroidism before surgery could be advocated, but this has rarely been reported. Methods: All patients hospitalised due to uncontrolled hyperthyroidism at the Karolinska University Hospital 2005–2015 and treated with Lugol’s solution were included. All electronic files were carefully reviewed manually, with focus on the cause of treatment and admission, demographic data, and effects of iodine on thyroid hormone levels and pulse frequency. Results: Twenty-seven patients were included. Lugol’s solution had been chosen due to agranulocytosis in 9 (33%, hepatotoxicity in 2 (7%, other side effects in 11 (41% and poor adherence to medication in 5 (19%. Levels of free T4, free T3 and heart rate decreased significantly after 5–9 days of iodine therapy (free T4 53–20 pmol/L, P = 0.0002; free T3 20–6.5 pmol/L, P = 0.04; heart rate 87–76 beats/min P = 0.0007, whereas TSH remained unchanged. Side effects were noted in 4 (15% (rash n = 2, rash and vomiting n = 1, swelling of fingers n = 1. Thyroidectomy was performed in 26 patients (96% and one was treated with radioiodine; all treatments were without serious complications. Conclusion: Treatment of uncontrolled hyperthyroidism with Lugol’s solution before definitive treatment is safe and it decreases thyroid hormone levels and heart rate. Side effects were limited. Lugol’s solution could be recommended pre-operatively in Graves’ disease with failed medical treatment, especially if side effects to anti-thyroid drugs have occurred.

  3. The Search Performance Evaluation and Prediction in Exploratory Search

    OpenAIRE

    LIU, FEI

    2016-01-01

    The exploratory search for complex search tasks requires an effective search behavior model to evaluate and predict user search performance. Few studies have investigated the relationship between user search behavior and search performance in exploratory search. This research adopts a mixed approach combining search system development, user search experiment, search query log analysis, and multivariate regression analysis to resolve the knowledge gap. Through this study, it is shown that expl...

  4. A new approach to road accident rescue.

    Science.gov (United States)

    Morales, Alejandro; González-Aguilera, Diego; López, Alfonso I; Gutiérrez, Miguel A

    2016-01-01

    This article develops and validates a new methodology and tool for rescue assistance in traffic accidents, with the aim of improving its efficiency and safety in the evacuation of people, reducing the number of victims in road accidents. Different tests supported by professionals and experts have been designed under different circumstances and with different categories of damaged vehicles coming from real accidents and simulated trapped victims in order to calibrate and refine the proposed methodology and tool. To validate this new approach, a tool called App_Rescue has been developed. This tool is based on the use of a computer system that allows an efficient access to the technical information of the vehicle and sanitary information of the common passengers. The time spent during rescue using the standard protocol and the proposed method was compared. This rescue assistance system allows us to make vital information accessible in posttrauma care services, improving the effectiveness of interventions by the emergency services, reducing the rescue time and therefore minimizing the consequences involved and the number of victims. This could often mean saving lives. In the different simulated rescue operations, the rescue time has been reduced an average of 14%.

  5. Boulder Food Rescue: An Innovative Approach to Reducing Food Waste and Increasing Food Security.

    Science.gov (United States)

    Sewald, Craig A; Kuo, Elena S; Dansky, Hana

    2018-05-01

    Food waste and food insecurity are both significant issues in communities throughout the U.S., including Boulder, Colorado. As much as 40% of the food produced in the U.S. goes uneaten and ends up in landfills. Nearly 13% of people in the Boulder region experience some level of food insecurity. Founded in 2011, Boulder Food Rescue supports community members to create their own food security through a participatory approach to an emergency food system. The organization uses a web-application "robot" to manage a schedule of volunteers. They coordinate with individuals at low-income senior housing sites, individual housing sites, family housing sites, after-school programs, and pre-schools to set up no-cost grocery programs stocked with food from local markets and grocers that would otherwise go to waste. Each site coordinator makes decisions about how, when, and where food delivery and distribution will occur. The program also conducts robust, real-time data collection and analysis. Boulder Food Rescue is a member and manager of the Food Rescue Alliance, and its model has been replicated and adapted by other cities, including Denver, Colorado Springs, Seattle, Jackson Hole, Minneapolis, Binghamton, and in the Philippines. Information for this special article was collected through key informant interviews with current and former Boulder Food Rescue staff and document review of Boulder Food Rescue materials. Boulder Food Rescue's open source software is available to other communities; to date, 40 cities have used the tool to start their own food rescue organizations. Boulder Food Rescue hopes to continue spreading this model to other cities that are considering ways to reduce food waste and increase food security. This article is part of a supplement entitled Building Thriving Communities Through Comprehensive Community Health Initiatives, which is sponsored by Kaiser Permanente, Community Health. Copyright © 2018 American Journal of Preventive Medicine. Published by

  6. Mobile Search and Advertising

    OpenAIRE

    Lovitskii, Vladimir; McCaffery, Colin; Thrasher, Michael; Traynor, David; Wright, Peter

    2009-01-01

    Mobile advertising is a rapidly growing sector providing brands and marketing agencies the opportunity to connect with consumers beyond traditional and digital media and instead communicate directly on their mobile phones. Mobile advertising will be intrinsically linked with mobile search, which has transported from the internet to the mobile and is identified as an area of potential growth. The result of mobile searching show that as a general rule such search result exceed 1...

  7. Teleautonomous Control on Rescue Robot Prototype

    Directory of Open Access Journals (Sweden)

    Son Kuswadi

    2012-12-01

    Full Text Available Robot application in disaster area can help responder team to save victims. In order to finish task, robot must have flexible movement mechanism so it can pass through uncluttered area. Passive linkage can be used on robot chassis so it can give robot flexibility. On physical experiments, robot is succeeded to move through gravels and 5 cm obstacle. Rescue robot also has specialized control needs. Robot must able to be controlled remotely. It also must have ability to move autonomously. Teleautonomous control method is combination between those methods. It can be concluded from experiments that on teleoperation mode, operator must get used to see environment through robot’s camera. While on autonomous mode, robot is succeeded to avoid obstacle and search target based on sensor reading and controller program. On teleautonomous mode, robot can change control mode by using bluetooth communication for data transfer, so robot control will be more flexible.

  8. Sirolimus for rescue and primary immunosuppression in transplanted children receiving tacrolimus.

    Science.gov (United States)

    Sindhi, R; Webber, S; Venkataramanan, R; McGhee, W; Phillips, S; Smith, A; Baird, C; Iurlano, K; Mazariegos, G; Cooperstone, B; Holt, D W; Zeevi, A; Fung, J J; Reyes, J

    2001-09-15

    The role of sirolimus (SRL) as a rescue agent (n=42) and as a component of primary immunosuppression (n=8) was evaluated in a mixed population of 50 transplanted children receiving tacrolimus (liver: 26, heart: 5, intestinal: 5, liver-intestine: 9, lung: 1, bone marrow: 1, liver-kidney: 1, multivisceral: 1). Rescue indications for tacrolimus (TAC) failure were recurrent acute rejection and acute rejection complicating withdrawal of immunosuppression in posttransplant lymphoproliferative disorder (PTLD). Rescue indications for TAC toxicity were nephrotoxicity, pancreatitis, seizures, hypertrophic cardiomyopathy, and graft-versus-host disease. Mean age at rescue was 11.5 years and mean follow-up was 204 (range 18-800) days. As primary immunosuppression, SRL+TAC prevented early acute rejection in 7/8 children. The indication for rescue resolved in 33/42 children. In children with TAC toxicity, this was associated with decrease in TAC doses by 50%, significant improvements in renal function, and continuing decline in Epstein-Barr virus (EBV) viral load in PTLD patients. Serious adverse events led to discontinuation of SRL in 9/42 rescue patients, 3 of them also experienced acute rejection. Three additional children also experienced acute rejection on SRL therapy (overall incidence 6/50, 12%). Pharmacokinetic analysis in the first week of SRL administration suggested a short half-life (11.8+/-5.5 hr, n=21). SRL and reduced-dose TAC may achieve adequate immunosuppression without compromising renal function or enhancing EBV viremia significantly.

  9. Reading wiring diagrams made easier for maintenance operators: contribution from research in visual attention and visual search

    International Nuclear Information System (INIS)

    Ponthieu, L.; Wolfe, J.M.

    1994-07-01

    This work has been carried out while the author was visiting the Visual Psychophysics lab at the Center for Ophthalmic Research, Harvard Medical School. The general framework is the design of a wiring diagrams visualization system for maintenance operators in electric plants. This study concentrates on how knowledge and experimental techniques from visual attention can help this goal. From this standpoint, the visualization system must best exploit the human visual system abilities. As electronic databases containing all the diagrams will soon be available, it is important to think in advance the display techniques. Presently, maintenance operators favor working with paper printouts even where such databases are already available. The study shows why such an approach is valuable for the design of a display that fits the operator's tasks. Beyond that, this work has been a mean to learn the experimental techniques of cognitive sciences in an applied frame. (authors). 9 figs., 5 annexes

  10. Canadian Air Force Leadership and Command: Implications for the Human Dimension of Expeditionary Air Force Operations

    Science.gov (United States)

    2006-11-01

    HTP ) at Rivers. The RCAF purchased six CH-113 Labradors, which were similar to the Voyageurs in many ways, for search and rescue (SAR) work. The Army...Voyageurs were subsequently modified to the Labrador configuration and re-roled as SAR aircraft in 1975. The RCASC’s No. 1 HTP would form the basis...doctrine manual (B-GA-400 Out of the Sun) includes no reference to expeditionary operations, while the companion support doctrine manual (B-GA-410

  11. Dragon Operations: Hostage Rescues in the Congo, 1964-1965 (Leavenworth Papers, Number 14)

    Science.gov (United States)

    1988-01-01

    lying in the street. 28 The corpse of Dr. Carlson 103 Off-loading medical supplies and food at Stanley.ville The paras’ assembly of the survivors was...attempted to care for the refugees- providing food , water, and shelter from rebel fire-Strobaugh and the · Belgians worked feverishly to get them safely...Georges Ledant, Colonel e.r. Belgian Army, interviews with the author, Ville Franche , France, 9 January 1986: Vandewalle interviews; and Janssens

  12. Orthotopic liver transplantation as a rescue operation for recurrent hepatocellular carcinoma after partial hepatectomy

    OpenAIRE

    Shao, Zhuo; Lopez, Rocio; Shen, Bo; Yang, Guang-Shun

    2008-01-01

    AIM: To compare post-orthotopic liver transplantation (OLT) survival between patients with recurrent hepatocellular carcinoma (HCC) after partial hepatectomy and those who received de novo OLT for HCC and to assess the risk factors associated with post-OLT mortality.

  13. Storytelling and Ethnographic Intersections: Vietnamese Adoptees and Rescue Narratives

    Science.gov (United States)

    Cherot, Natalie

    2009-01-01

    The exit of approximately 2,000 Vietnamese orphans in April 1975 through Operation Babylift is a key part of Vietnam War debates. The Babylift volunteers, American women who aided with the children's evacuation, published autobiographies of their involvement and publicly commemorated the history. This article uses pedagogy, collective memory, and…

  14. Conservation and the 4 Rs, which are rescue, rehabilitation, release, and research.

    Science.gov (United States)

    Pyke, Graham H; Szabo, Judit K

    2018-02-01

    Vertebrate animals can be injured or threatened with injury through human activities, thus warranting their "rescue." Details of wildlife rescue, rehabilitation, release, and associated research (our 4 Rs) are often recorded in large databases, resulting in a wealth of available information. This information has huge research potential and can contribute to understanding of animal biology, anthropogenic impacts on wildlife, and species conservation. However, such databases have been little used, few studies have evaluated factors influencing success of rehabilitation and/or release, recommended actions to conserve threatened species have rarely arisen, and direct benefits for species conservation are yet to be demonstrated. We therefore recommend that additional research be based on data from rescue, rehabilitation, and release of animals that is broader in scope than previous research and would have community support. © 2017 Society for Conservation Biology.

  15. Austrian Daily Climate Data Rescue and Quality Control

    Science.gov (United States)

    Jurkovic, A.; Lipa, W.; Adler, S.; Albenberger, J.; Lechner, W.; Swietli, R.; Vossberg, I.; Zehetner, S.

    2010-09-01

    Checked climate datasets are a "conditio sine qua non" for all projects that are relevant for environment and climate. In the framework of climate change studies and analysis it is essential to work with quality controlled and trustful data. Furthermore these datasets are used as input for various simulation models. In regard to investigations of extreme events, like strong precipitation periods, drought periods and similar ones we need climate data in high temporal resolution (at least in daily resolution). Because of the historical background - during Second World War the majority of our climate sheets were sent to Berlin, where the historical sheets were destroyed by a bomb attack and so important information got lost - only several climate sheets, mostly duplicates, before 1939 are available and stored in our climate data archive. In 1970 the Central Institute for Meteorology and Geodynamics in Vienna started a first attempt to digitize climate data by means of punch cards. With the introduction of a routinely climate data quality control in 1984 we can speak of high-class-checked daily data (finally checked data, quality flag 6). Our group is working on the processing of digitization and quality control of the historical data for the period 1872 to 1983 for 18 years. Since 2007 it was possible to intensify the work (processes) in the framework of an internal project, namely Austrian Climate Data Rescue and Quality Control. The aim of this initiative was - and still is - to supply daily data in an outstanding good and uniform quality. So this project is a kind of pre-project for all scientific projects which are working with daily data. In addition to routine quality checks (that are running since 1984) using the commercial Bull Software we are testing our data with additional open source software, namely ProClim.db. By the use of this spatial and statistical test procedure, the elements air temperature and precipitation - for several sites in Carinthia - could

  16. Modeling the manipulator and flipper pose effects on tip over stability of a tracked mobile manipulator

    CSIR Research Space (South Africa)

    Dube, C

    2011-11-01

    Full Text Available Mobile manipulators are used in a number of different applications such as bomb disposal, mining robotics, and search and rescue operations. These mobile manipulators are highly susceptible to tip over due to the motion of the manipulator...

  17. PSO-Based Robot Path Planning for Multisurvivor Rescue in Limited Survival Time

    Directory of Open Access Journals (Sweden)

    N. Geng

    2014-01-01

    Full Text Available Since the strength of a trapped person often declines with time in urgent and dangerous circumstances, adopting a robot to rescue as many survivors as possible in limited time is of considerable significance. However, as one key issue in robot navigation, how to plan an optimal rescue path of a robot has not yet been fully solved. This paper studies robot path planning for multisurvivor rescue in limited survival time using a representative heuristic, particle swarm optimization (PSO. First, the robot path planning problem including multiple survivors is formulated as a discrete optimization one with high constraint, where the number of rescued persons is taken as the unique objective function, and the strength of a trapped person is used to constrain the feasibility of a path. Then, a new integer PSO algorithm is presented to solve the mathematical model, and several new operations, such as the update of a particle, the insertion and inversion operators, and the rapidly local search method, are incorporated into the proposed algorithm to improve its effectiveness. Finally, the simulation results demonstrate the capacity of our method in generating optimal paths with high quality.

  18. Searching low and high

    DEFF Research Database (Denmark)

    Laursen, Keld; Salter, Ammon

    2003-01-01

    AbstractThis paper examines the factors that influence whether firms draw from universities in theirinnovative activities. The link between the universities and industrial innovation, and the role ofdifferent search strategies in influencing the propensity of firms to use universities is explored.......The results suggest that firms who adopt `open' search strategies and invest in R&D are morelikely than other firms to draw from universities, indicating that managerial choice matters inshaping the propensity of firms to draw from universities.Key words: University-industry links, innovation, external search...

  19. Factors influencing mine rescue team behaviors.

    Science.gov (United States)

    Jansky, Jacqueline H; Kowalski-Trakofler, K M; Brnich, M J; Vaught, C

    2016-01-01

    A focus group study of the first moments in an underground mine emergency response was conducted by the National Institute for Occupational Safety and Health (NIOSH), Office for Mine Safety and Health Research. Participants in the study included mine rescue team members, team trainers, mine officials, state mining personnel, and individual mine managers. A subset of the data consists of responses from participants with mine rescue backgrounds. These responses were noticeably different from those given by on-site emergency personnel who were at the mine and involved with decisions made during the first moments of an event. As a result, mine rescue team behavior data were separated in the analysis and are reported in this article. By considering the responses from mine rescue team members and trainers, it was possible to sort the data and identify seven key areas of importance to them. On the basis of the responses from the focus group participants with a mine rescue background, the authors concluded that accurate and complete information and a unity of purpose among all command center personnel are two of the key conditions needed for an effective mine rescue operation.

  20. Fuzzing and Vulnerabilities Search

    OpenAIRE

    Stanislav Evgenyevich Kirillov; Nikolai Petrovich Lavrentiev

    2013-01-01

    Fuzzing for vulnerabilities can be very effective if we know the input data format. This work contains description of network message format recovery algorithm and the usage of restored data model in fuzzing and vulnerabilities search.

  1. Fuzzing and Vulnerabilities Search

    Directory of Open Access Journals (Sweden)

    Stanislav Evgenyevich Kirillov

    2013-02-01

    Full Text Available Fuzzing for vulnerabilities can be very effective if we know the input data format. This work contains description of network message format recovery algorithm and the usage of restored data model in fuzzing and vulnerabilities search.

  2. 18/20 T high magnetic field scanning tunneling microscope with fully low voltage operability, high current resolution, and large scale searching ability.

    Science.gov (United States)

    Li, Quanfeng; Wang, Qi; Hou, Yubin; Lu, Qingyou

    2012-04-01

    We present a home-built 18/20 T high magnetic field scanning tunneling microscope (STM) featuring fully low voltage (lower than ±15 V) operability in low temperatures, large scale searching ability, and 20 fA high current resolution (measured by using a 100 GOhm dummy resistor to replace the tip-sample junction) with a bandwidth of 3.03 kHz. To accomplish low voltage operation which is important in achieving high precision, low noise, and low interference with the strong magnetic field, the coarse approach is implemented with an inertial slider driven by the lateral bending of a piezoelectric scanner tube (PST) whose inner electrode is axially split into two for enhanced bending per volt. The PST can also drive the same sliding piece to inertial slide in the other bending direction (along the sample surface) of the PST, which realizes the large area searching ability. The STM head is housed in a three segment tubular chamber, which is detachable near the STM head for the convenience of sample and tip changes. Atomic resolution images of a graphite sample taken under 17.6 T and 18.0001 T are presented to show its performance. © 2012 American Institute of Physics

  3. Concern over radiation exposure and psychological distress among rescue workers following the Great East Japan Earthquake

    Directory of Open Access Journals (Sweden)

    Matsuoka Yutaka

    2012-05-01

    Full Text Available Abstract Background On March 11, 2011, the Great East Japan Earthquake and tsunami that followed caused severe damage along Japans northeastern coastline and to the Fukushima Daiichi nuclear power plant. To date, there are few reports specifically examining psychological distress in rescue workers in Japan. Moreover, it is unclear to what extent concern over radiation exposure has caused psychological distress to such workers deployed in the disaster area. Methods One month after the disaster, 424 of 1816 (24% disaster medical assistance team workers deployed to the disaster area were assessed. Concern over radiation exposure was evaluated by a single self-reported question. General psychological distress was assessed with the Kessler 6 scale (K6, depressive symptoms with the Center for Epidemiologic Studies Depression Scale (CES-D, fear and sense of helplessness with the Peritraumatic Distress Inventory (PDI, and posttraumatic stress symptoms with the Impact of Event Scale-Revised (IES-R. Results Radiation exposure was a concern for 39 (9.2% respondents. Concern over radiation exposure was significantly associated with higher scores on the K6, CES-D, PDI, and IES-R. After controlling for age, occupation, disaster operation experience, duration of time spent watching earthquake news, and past history of psychiatric illness, these associations remained significant in men, but did not remain significant in women for the CES-D and PDI scores. Conclusion The findings suggest that concern over radiation exposure was strongly associated with psychological distress. Reliable, accurate information on radiation exposure might reduce deployment-related distress in disaster rescue workers.

  4. Ensemble-based computational approach discriminates functional activity of p53 cancer and rescue mutants.

    Directory of Open Access Journals (Sweden)

    Özlem Demir

    2011-10-01

    Full Text Available The tumor suppressor protein p53 can lose its function upon single-point missense mutations in the core DNA-binding domain ("cancer mutants". Activity can be restored by second-site suppressor mutations ("rescue mutants". This paper relates the functional activity of p53 cancer and rescue mutants to their overall molecular dynamics (MD, without focusing on local structural details. A novel global measure of protein flexibility for the p53 core DNA-binding domain, the number of clusters at a certain RMSD cutoff, was computed by clustering over 0.7 µs of explicitly solvated all-atom MD simulations. For wild-type p53 and a sample of p53 cancer or rescue mutants, the number of clusters was a good predictor of in vivo p53 functional activity in cell-based assays. This number-of-clusters (NOC metric was strongly correlated (r(2 = 0.77 with reported values of experimentally measured ΔΔG protein thermodynamic stability. Interpreting the number of clusters as a measure of protein flexibility: (i p53 cancer mutants were more flexible than wild-type protein, (ii second-site rescue mutations decreased the flexibility of cancer mutants, and (iii negative controls of non-rescue second-site mutants did not. This new method reflects the overall stability of the p53 core domain and can discriminate which second-site mutations restore activity to p53 cancer mutants.

  5. Collaboration and Interconnectivity: Nottinghamshire Fire and Rescue Services and Higher Education Institutions in Nottingham

    Science.gov (United States)

    Murphy, Peter; Greenhalgh, Kirsten; Parkin, Craig

    2013-01-01

    This article will describe the developing relationship between Nottinghamshire Fire and Rescue Services and the two higher education institutions in Nottingham. It will chronicle how a very traditional relationship has been transformed, initially by a simple consultancy project, into a much closer working relationship characterised by a much…

  6. Remote damage control during the attacks on Paris: Lessons learned by the Paris Fire Brigade and evolutions in the rescue system.

    Science.gov (United States)

    Lesaffre, Xavier; Tourtier, Jean-Pierre; Violin, Yann; Frattini, Benoit; Rivet, Catherine; Stibbe, Olivier; Faure, Florian; Godefroy, Anne; Gallet, Jean-Claude; Ausset, Sylvain

    2017-06-01

    On November 13, 2015, in 40 minutes, Paris suffered four suicide bombers attacks; shootings at three different restaurant terraces; and an attack on the Bataclan concert hall, resulting in 130 dead and 495 wounded. How did the Parisian rescue system respond and how did it evolve since?We proved we could deploy quickly wide prehospital and hospital resources and teams' equipment and preparedness is being further developed. To secure a swifter initial response, we need a better integration of the operators of the rescue chain with a simpler and more robust organization as well as improved communications channels. We must continue to anticipate and prepare for possible future attacks.

  7. A Cloud Robotics Based Service for Managing RPAS in Emergency, Rescue and Hazardous Scenarios

    Science.gov (United States)

    Silvagni, Mario; Chiaberge, Marcello; Sanguedolce, Claudio; Dara, Gianluca

    2016-04-01

    Cloud robotics and cloud services are revolutionizing not only the ICT world but also the robotics industry, giving robots more computing capabilities, storage and connection bandwidth while opening new scenarios that blend the physical to the digital world. In this vision, new IT architectures are required to manage robots, retrieve data from them and create services to interact with users. Among all the robots this work is mainly focused on flying robots, better known as drones, UAV (Unmanned Aerial Vehicle) or RPAS (Remotely Piloted Aircraft Systems). The cloud robotics approach shifts the concept of having a single local "intelligence" for every single UAV, as a unique device that carries out onboard all the computation and storage processes, to a more powerful "centralized brain" located in the cloud. This breakthrough opens new scenarios where UAVs are agents, relying on remote servers for most of their computational load and data storage, creating a network of devices where they can share knowledge and information. Many applications, using UAVs, are growing as interesting and suitable devices for environment monitoring. Many services can be build fetching data from UAVs, such as telemetry, video streaming, pictures or sensors data; once. These services, part of the IT architecture, can be accessed via web by other devices or shared with other UAVs. As test cases of the proposed architecture, two examples are reported. In the first one a search and rescue or emergency management, where UAVs are required for monitoring intervention, is shown. In case of emergency or aggression, the user requests the emergency service from the IT architecture, providing GPS coordinates and an identification number. The IT architecture uses a UAV (choosing among the available one according to distance, service status, etc.) to reach him/her for monitoring and support operations. In the meantime, an officer will use the service to see the current position of the UAV, its

  8. Search and imperative programming

    OpenAIRE

    Apt, Krzysztof; Schaerf, A.

    1996-01-01

    textabstractWe augment the expressive power of imperative programming in order to make it a more attractive vehicle for problems that involve search.The proposed additions are limited yet powerful and are inspired by the logic programming paradigm.We illustrate their use by presenting solutions to a number of classical problems, including the straight search problem, the knapsack problem, and the 8 queens problem. These solutions are substantially simpler than their counterparts written in th...

  9. Retrospective on the construction and practice of a state-level emergency medical rescue team.

    Science.gov (United States)

    Lei, Zhang; Haitao, Guo; Xin, Wang; Yundou, Wang

    2014-10-01

    For the past few years, disasters like earthquakes, landslides, mudslides, tsunamis, and traffic accidents have occurred with an ever-growing frequency, coverage, and intensity greatly beyond the expectation of the public. In order to respond effectively to disasters and to reduce casualties and property damage, countries around the world have invested more efforts in the theoretical study of emergency medicine and the construction of emergency medical rescue forces. Consequently, emergency medical rescue teams of all scales and types have come into being and have played significant roles in disaster response work. As the only state-level emergency medical rescue force from the Chinese People's Armed Police Forces, the force described here has developed, through continuous learning and practice, a characteristic mode in terms of grouping methods, equipment system construction, and training.

  10. Combat Rescue Helicopter (CRH)

    Science.gov (United States)

    2015-12-01

    Selected Acquisition Report (SAR) RCS: DD-A&T(Q&A)823-479 Combat Rescue Helicopter (CRH) As of FY 2017 President’s Budget Defense Acquisition...Name Combat Rescue Helicopter (CRH) DoD Component Air Force Responsible Office References SAR Baseline (Development Estimate) Defense Acquisition... Helicopter (CRH) system will provide Personnel Recovery (PR) forces with a vertical takeoff and landing aircraft that is quickly deployable and

  11. Clinical emergency treatment of 68 critical patients with severe organophosphorus poisoning and prognosis analysis after rescue.

    Science.gov (United States)

    Dong, Hui; Weng, Yi-Bing; Zhen, Gen-Shen; Li, Feng-Jie; Jin, Ai-Chun; Liu, Jie

    2017-06-01

    This study reports the clinical emergency treatment of 68 critical patients with severe organophosphorus poisoning, and analyzes the prognosis after rescue.The general data of 68 patients with severe organophosphorus poisoning treated in our hospital were retrospectively analyzed. These patients were divided into 2 groups: treatment group, and control group. Patients in the control group received routine emergency treatment, while patients in the treatment group additionally received hemoperfusion plus hemodialysis on the basis of routine emergency treatment. The curative effects in these 2 groups and the prognosis after rescue were compared.Compared with the control group, atropinization time, recovery time of cholinesterase activity, recovery time of consciousness, extubation time, and length of hospital stay were shorter (P poisoning rebound rate was significantly lower (P treatment group.Hemoperfusion and hemodialysis on the basis of routine emergency treatment for critical patients with organophosphorus poisoning can improve rescue outcomes and improve the prognosis of patients, which should be popularized.

  12. Multi-agent cooperation rescue algorithm based on influence degree and state prediction

    Science.gov (United States)

    Zheng, Yanbin; Ma, Guangfu; Wang, Linlin; Xi, Pengxue

    2018-04-01

    Aiming at the multi-agent cooperative rescue in disaster, a multi-agent cooperative rescue algorithm based on impact degree and state prediction is proposed. Firstly, based on the influence of the information in the scene on the collaborative task, the influence degree function is used to filter the information. Secondly, using the selected information to predict the state of the system and Agent behavior. Finally, according to the result of the forecast, the cooperative behavior of Agent is guided and improved the efficiency of individual collaboration. The simulation results show that this algorithm can effectively solve the cooperative rescue problem of multi-agent and ensure the efficient completion of the task.

  13. Advance & attack: technology demonstrator to the rescue.....and beyond

    CSIR Research Space (South Africa)

    Van Deventer, Martha J

    2008-10-01

    Full Text Available ; funding agencies; institutional resources e.g. SAMI Identification of collaborators Personal networks; EU portal; literature; search engines; ACGT expert list Proposal writing MS Word / Open Office; templates; generic proposal Literature review... review & indexing List of search engines; Internal shared database of indexed articles; Person to assist in retrieval of relevant literature Project management Proper pm system; MS Project Scientific workflow Even more sophisticated instruments...

  14. Expectations of a business rescue plan: international directives for ...

    African Journals Online (AJOL)

    Kirstam

    2014-09-01

    Sep 1, 2014 ... 10Key words: business rescue, South African Companies Act, business ... countries such as Germany, Australia, the United Kingdom (UK) and ...... operating statistics and detailed cash flow projections is needed for sound risk.

  15. A Multi-purpose Rescue Vehicle and a human–robot interface architecture for remote assistance in ITER

    Energy Technology Data Exchange (ETDEWEB)

    Soares, João [Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa (Portugal); Vale, Alberto, E-mail: avale@ipfn.tecnico.ulisboa.pt [Instituto de Plasmas e Fusão Nuclear, Instituto SuperiorTécnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa (Portugal); Ventura, Rodrigo, E-mail: rodrigo.ventura@isr.tecnico.ulisboa.pt [Laboratório de Robótica e Sistemas em Engenharia eCiência, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa (Portugal)

    2015-10-15

    Highlights: • Design of an omnidirectional vehicle equipped with cameras and laser range finders. • Two robotic manipulators that slide over the vehicle's body to perform independent tasks. • Architecture to connect the control system, communication, power, navigation and HMI. • An immersive interface HMI with augmented reality features with head mounted display. - Abstract: The remote handling (RH) plays an important role in nuclear test facilities, such as in ITER, for in-vessel and ex-vessel maintenance operations. Unexpected situations may occur when RH devices fail. Since no human being is allowed during the RH operations, a Multi-purpose Rescue Vehicle (MPRV) must be required for providing support in site. This paper proposes a design of a MPRV, i.e., a mobile platform equipped with different sensors and two manipulators with different sets of end-effectors. A human–machine interface is also proposed to remotely operate the MPRV and to carry out rescue and recovery operations.

  16. Governance: Blending Bureaucratic Rules with Day to Day Operational Realities Comment on "Governance, Government, and the Search for New Provider Models".

    Science.gov (United States)

    Chinitz, David P

    2016-05-31

    Richard Saltman and Antonio Duran take up the challenging issue of governance in their article "Governance, Government and the Search for New Provider Models," and use two case studies of health policy changes in Sweden and Spain to shed light on the subject. In this commentary, I seek to link their conceptualization of governance, especially its interrelated roles at the macro, meso, and micro levels of health systems, with the case studies on which they report. While the case studies focus on the shifts in governance between the macro and meso levels and their impacts on achievement of desired policy outcomes, they also highlight the need to better integrate the dynamics of day to day operations within micro organizations into the overall governance picture. © 2016 by Kerman University of Medical Sciences.

  17. Governance: Blending Bureaucratic Rules with Day to Day Operational Realities; Comment on “Governance, Government, and the Search for New Provider Models”

    Directory of Open Access Journals (Sweden)

    David P Chinitz

    2016-09-01

    Full Text Available Richard Saltman and Antonio Duran take up the challenging issue of governance in their article “Governance, Government and the Search for New Provider Models,” and use two case studies of health policy changes in Sweden and Spain to shed light on the subject. In this commentary, I seek to link their conceptualization of governance, especially its interrelated roles at the macro, meso, and micro levels of health systems, with the case studies on which they report. While the case studies focus on the shifts in governance between the macro and meso levels and their impacts on achievement of desired policy outcomes, they also highlight the need to better integrate the dynamics of day to day operations within micro organizations into the overall governance picture.

  18. A Technical and Policy Case Study of Large-Scale Rescue and Redistribution of Perishable Foods by the "Leket Israel" Food Bank.

    Science.gov (United States)

    Philip, Dana; Hod-Ovadia, Smadar; Troen, Aron M

    2017-06-01

    Food banks seeking to rescue and redistribute highly nutritious perishable foods to simultaneously alleviate food insecurity and reduce food waste often encounter practical, ethical, and political dilemmas. We present a case study of "Leket Israel," an Israeli food bank that uses an effective large-scale logistical model for the rescue and redistribution of perishable food and discuss the challenges and solutions it offers. The organization operates in a rich country plagued with poverty and inequality, where the government passively encourages nongovernmental organizations to respond to the serious and growing problem of food insecurity. Operating under a business-to-business model, Leket Israel distributes food via intermediary nonprofit organizations (NPOs), enriching the food they provide with fresh produce. Food is obtained through an Agricultural Gleaning project, Self-Growing Farm project, and Meal Rescue project. The partnering NPOs then distribute the food to people in need. Although the rescue and redistribution of highly perishable food is more costly and complex than acquiring, storing, and distributing dried and staple foods and it requires specialized knowledge and infrastructure in order to maintain rigorous safety standards, it improves the nutritional quality of the aid. In 2015, Leket Israel distributed 15 217 389 kg of food, 90% of which was fruit and vegetables, to 180 partnering NPOs nationwide, reaching an estimated 175 000 recipients. "Leket Israel" offers a valuable model that can be studied and emulated by international nutrition scientists, practitioners, and policy makers who are seeking to reduce food insecurity and food waste in other countries.

  19. Axion Searches, Old and New

    CERN Multimedia

    CERN. Geneva

    2005-01-01

    Outline of the lecture: Constraints from laboratory searches and astrophysics, axion cosmology, the cavity detector of dark matter axions, solar axion searches, laser experiments, a telescope search, macroscopic forces mediated by axions.

  20. Looking for trouble: a description of oculomotor search strategies during live CCTV operation

    OpenAIRE

    Stainer, Matthew J.; Scott-Brown, Kenneth C.; Tatler, Benjamin W.

    2013-01-01

    Recent research has begun to address how CCTV operators in the modern control room attempt to search for crime (e.g., Howard et al., 2011). However, an often-neglected element of the CCTV task is that the operators have at their disposal a multiplexed wall of scenes, and a single spot-monitor on which they can select any of these feeds for inspection. Here we examined how 2 trained CCTV operators used these sources of information to search from crime during a morning, afternoon, and night-tim...

  1. 33 CFR 149.303 - What survival craft and rescue boats may be used on a manned deepwater port?

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false What survival craft and rescue boats may be used on a manned deepwater port? 149.303 Section 149.303 Navigation and Navigable Waters... craft and rescue boats may be used on a manned deepwater port? (a) Each survival craft on a manned...

  2. The Rescue and Rehabilitation of Koalas (Phascolarctos cinereus in Southeast Queensland

    Directory of Open Access Journals (Sweden)

    Emily Burton

    2016-09-01

    Full Text Available Koala populations in southeast Queensland are under threat from many factors, particularly habitat loss, dog attack, vehicle trauma and disease. Animals not killed from these impacts are often rescued and taken into care for rehabilitation, and eventual release back to the wild if deemed to be healthy. This study investigated current rescue, rehabilitation and release data for koalas admitted to the four major wildlife hospitals in southeast Queensland (Australia Zoo Wildlife Hospital (AZWH, Currumbin Wildlife Sanctuary Hospital (CWH, Moggill Koala Hospital (MKH and the Royal Society for the Prevention Against Cruelty to Animals Wildlife Hospital at Wacol (RSPCA, and suggests aspects of the practice that may be changed to improve its contribution to the preservation of the species. It concluded that: (a the main threats to koalas across southeast Queensland were related to urbanization (vehicle collisions, domestic animal attacks and the disease chlamydiosis; (b case outcomes varied amongst hospitals, including time spent in care, euthanasia and release rates; and (c the majority (66.5% of rescued koalas were either euthanized or died in care with only 27% released back to the wild. The results from this study have important implications for further research into koala rescue and rehabilitation to gain a better understanding of its effectiveness as a conservation strategy.

  3. The Rescue and Rehabilitation of Koalas (Phascolarctos cinereus) in Southeast Queensland.

    Science.gov (United States)

    Burton, Emily; Tribe, Andrew

    2016-09-15

    Koala populations in southeast Queensland are under threat from many factors, particularly habitat loss, dog attack, vehicle trauma and disease. Animals not killed from these impacts are often rescued and taken into care for rehabilitation, and eventual release back to the wild if deemed to be healthy. This study investigated current rescue, rehabilitation and release data for koalas admitted to the four major wildlife hospitals in southeast Queensland (Australia Zoo Wildlife Hospital (AZWH), Currumbin Wildlife Sanctuary Hospital (CWH), Moggill Koala Hospital (MKH) and the Royal Society for the Prevention Against Cruelty to Animals Wildlife Hospital at Wacol (RSPCA)), and suggests aspects of the practice that may be changed to improve its contribution to the preservation of the species. It concluded that: (a) the main threats to koalas across southeast Queensland were related to urbanization (vehicle collisions, domestic animal attacks and the disease chlamydiosis); (b) case outcomes varied amongst hospitals, including time spent in care, euthanasia and release rates; and (c) the majority (66.5%) of rescued koalas were either euthanized or died in care with only 27% released back to the wild. The results from this study have important implications for further research into koala rescue and rehabilitation to gain a better understanding of its effectiveness as a conservation strategy.

  4. Analysis of factors related to military training injury and the effect of self-rescue and buddy rescue on the final result of the injury in tank crew of the armored forces

    Directory of Open Access Journals (Sweden)

    Rong-bin ZHOU

    2011-09-01

    Full Text Available Objective To analyze the factors related to military training injury and the effect of self-rescue and buddy rescue on the result of the injury in the soldiers.Methods All data were statistically classified with cluster sampling according to the diagnosis standard of Chinese PLA for analysis.Investigation was conducted in 1028 soldiers of the armored forces with questionnaire,and non-condition logistic regression analysis was applied.Results The total incidence of military training injury was 40.2%.Of all the injured soldiers,36.80% of them served for one year only,and the incidence of injury was obviously higher than those who had served in armed forces for 2 or 3 years.Unconditioned regression analysis revealed that the main causes related to military training injury in the soldiers were as follows: the items of training,the terrain feature,motion sickness,self-rescue and buddy rescue training,and whether the action consistent with the standards.The rehabilitation rate within one month was significantly higher in those who underwent self-rescue or buddy rescue(93.8% and 94.2%,respectively than those who did not undergo self-rescue or buddy rescue(76.3%,76.7%,respectively,P < 0.001.Conclusions The incidence of military training injury in the armored forces is high.It should be emphysized that soldiers with one year of military service should be partioularly taken care to prevent from injuries.Many factors may influence the military training injury,and protective measures should be taken.Those who have the knowledge of self-rescue or undergo buddy rescue will have higher rehabilitation rate within one month.

  5. Looking for trouble: a description of oculomotor search strategies during live CCTV operation.

    Science.gov (United States)

    Stainer, Matthew J; Scott-Brown, Kenneth C; Tatler, Benjamin W

    2013-01-01

    Recent research has begun to address how CCTV operators in the modern control room attempt to search for crime (e.g., Howard et al., 2011). However, an often-neglected element of the CCTV task is that the operators have at their disposal a multiplexed wall of scenes, and a single spot-monitor on which they can select any of these feeds for inspection. Here we examined how 2 trained CCTV operators used these sources of information to search from crime during a morning, afternoon, and night-time shift. We found that they spent surprisingly little time viewing the multiplex wall, instead preferentially spending most of their time searching on the single-scene spot-monitor. Such search must require a sophisticated understanding of the surveilled environment, as the operators must make their selection of which screen to view based on their prediction of where crime is likely to occur. This seems to be reflected in the difference in the screens that they selected to view at different times of the day. For example, night-clubs received close monitoring at night, but were seldom viewed in mid-morning. Such narrowing of search based on a contextual understanding of an environment is not a new idea (e.g., Torralba et al., 2006), and appears to contribute to operator's selection strategy. This research prompts new questions regarding the nature of representation that operators have of their environment, and how they might develop expectation-based search strategies to countermand the demands of the large influx of visual information. Future research should ensure not to neglect examination of operator behavior "in the wild" (Hutchins, 1995a), as such insights are difficult to gain from laboratory based paradigms alone.

  6. Quantum Search and Beyond

    Science.gov (United States)

    2008-07-02

    mechanics leads to non-local paradoxical effects (physicists sometimes call this "spooky action at a distance"). Spatial searching is the problem where...resource of EPR pairs, and that they use the states |0L〉 = |00〉+ |11〉 (|1L〉 = |00〉 − |11〉) to encode a logical zero (one). Note that each of them can set

  7. Search and Recommendation

    DEFF Research Database (Denmark)

    Bogers, Toine

    2014-01-01

    In just a little over half a century, the field of information retrieval has experienced spectacular growth and success, with IR applications such as search engines becoming a billion-dollar industry in the past decades. Recommender systems have seen an even more meteoric rise to success with wide...

  8. Search and imperative programming

    NARCIS (Netherlands)

    K.R. Apt (Krzysztof); A. Schaerf

    1996-01-01

    textabstractWe augment the expressive power of imperative programming in order to make it a more attractive vehicle for problems that involve search.The proposed additions are limited yet powerful and are inspired by the logic programming paradigm.We illustrate their use by presenting solutions to a

  9. Expectations of a business rescue plan: international directives for ...

    African Journals Online (AJOL)

    Expectations of a business rescue plan: international directives for Chapter 6 implementation. ... AFRICAN JOURNALS ONLINE (AJOL) · Journals · Advanced Search ... Preliminary analysis of business rescue plans suggested that a significant ...

  10. Rescuing--a universal phenomenon.

    Science.gov (United States)

    Little, John

    2014-12-01

    Rescuing, where the person is delivered from the immediacy of their conundrum by another, complicates management. The object of this paper is to understand the difficulty in relinquishing the rescuing role. Rescuing is a universal phenomenon in parenting, teaching and therapy that has developed over time through a variety of interwoven social, economic, psychological and clinical variables. © The Royal Australian and New Zealand College of Psychiatrists 2014.

  11. Rescuing Dogs in the Frederick Community | Poster

    Science.gov (United States)

    Many Frederick National Lab employees have a favorite cause to which they volunteer a significant amount of time. For Dianna Kelly, IT program manager/scientific program analyst, Office of Scientific Operations, and Courtney Kennedy, associate technical project manager, Business Enterprise Systems, that cause is dog rescue.

  12. Mechanical Construction and Propulsion Analysis of a Rescue Underwater Robot in the case of Drowning Persons

    Directory of Open Access Journals (Sweden)

    Angelo Bonfitto

    2018-04-01

    Full Text Available This paper presents the design of an unmanned and tele-operated robotized life-saving system aimed to work as a recovery tool in case of water-related disasters. The device is designed to save people in distress in the water, either conscious or unconscious, without exposing the rescuer’s life to risk. The data of in water accidents show that the greatest number of casualties occurs because of dangerous predicaments conducted by people who want to save other lives. All present solutions are based on aerial, surface or submarine systems needing a crew and able to save only conscious people. This paper intends to fill this gap in the literature by analyzing the main critical issues in the design of a marine autonomous rescue vehicle in terms of performance, capabilities of maneuver in rough sea conditions and the costs. The proposed robot is fully electric and tele-manipulated, from the shore in case of accidents near dry land, or directly from boats or helicopters if drowning is occurring in the open sea. The paper demonstrates the feasibility of a system and its readiness for prototyping phases while presenting a trade-off and cost analysis between six different configurations as well as illustrating in detail the design of the selected layout. The motivations behind the choice of diving strategy to tackle rough sea conditions are described along with the design and the numerical validations of the hydroplane and propulsion systems.

  13. Prices and heterogeneous search costs

    NARCIS (Netherlands)

    Luis Moraga-Gonzalez, Jose; Sandor, Zsolt; Wildenbeest, Matthijs R.

    2017-01-01

    We study price formation in a model of consumer search for differentiated products in which consumers have heterogeneous search costs. We provide conditions under which a pure-strategy symmetric Nash equilibrium exists and is unique. Search costs affect two margins-the intensive search margin (or

  14. Real-time implementations of acoustic signal enhancement techniques for aerial based surveillance and rescue applications

    Science.gov (United States)

    Ramos, Antonio L. L.; Shao, Zhili; Holthe, Aleksander; Sandli, Mathias F.

    2017-05-01

    The introduction of the System-on-Chip (SoC) technology has brought exciting new opportunities for the development of smart low cost embedded systems spanning a wide range of applications. Currently available SoC devices are capable of performing high speed digital signal processing tasks in software while featuring relatively low development costs and reduced time-to-market. Unmanned aerial vehicles (UAV) are an application example that has shown tremendous potential in an increasing number of scenarios, ranging from leisure to surveillance as well as in search and rescue missions. Video capturing from UAV platforms is a relatively straightforward task that requires almost no preprocessing. However, that does not apply to audio signals, especially in cases where the data is to be used to support real-time decision making. In fact, the enormous amount of acoustic interference from the surroundings, including the noise from the UAVs propellers, becomes a huge problem. This paper discusses a real-time implementation of the NLMS adaptive filtering algorithm applied to enhancing acoustic signals captured from UAV platforms. The model relies on a combination of acoustic sensors and a computational inexpensive algorithm running on a digital signal processor. Given its simplicity, this solution can be incorporated into the main processing system of an UAV using the SoC technology, and run concurrently with other required tasks, such as flight control and communications. Simulations and real-time DSP-based implementations have shown significant signal enhancement results by efficiently mitigating the interference from the noise generated by the UAVs propellers as well as from other external noise sources.

  15. Looking for trouble: A description of oculomotor search strategies during live CCTV operation.

    Directory of Open Access Journals (Sweden)

    Matthew James Stainer

    2013-09-01

    Full Text Available Recent research has begun to address how CCTV operators in the modern control room attempt to search for crime (e.g., Howard et al., 2011. However, an often-neglected element of the CCTV task is that the operators have at their disposal a multiplexed wall of scenes, and a single spot-monitor on which they can select any of these feeds for inspection. Here we examined how 2 trained CCTV operators used these sources of information to search from crime during a morning, afternoon and night-time shift. We found that they spent surprisingly little time viewing the multiplex wall, instead preferentially spending most of their time searching on the single-scene spot-monitor. Such search must require a sophisticated understanding of the surveilled environment, as the operators must make their selection of which screen to view based on their prediction of where crime is likely to occur. This seems to be reflected in the difference in the screens that they selected to view at different times of the day. For example, night-clubs received close monitoring at night, but were seldom viewed in mid-morning. Such narrowing of search based on a contextual understanding of an environment is not a new idea (e.g., Torralba et al., 2006, and appears to contribute to operator’s selection strategy. This research prompts new questions regarding the nature of representation that operators have of their environment, and how they might develop expectation-based search strategies to countermand the demands of the large influx of visual information. Future research should ensure not to neglect examination of operator behavior ‘in the wild’ (Hutchins, 1995a, as such insights are difficult to gain from laboratory based paradigms alone.

  16. Unwanted horses: The role of nonprofit equine rescue and sanctuary organizations.

    Science.gov (United States)

    Holcomb, K E; Stull, C L; Kass, P H

    2010-12-01

    Closure of US equine slaughter facilities in 2007 along with the concomitant economic recession have contributed to a sharp increase in the number of unwanted horses throughout the United States, with estimates totaling 100,000 horses per year. The objective of the study was to obtain comprehensive data regarding nonprofit organizations caring for unwanted horses, along with the characteristics and outcome of horses relinquished to these organizations. Nonprofit organizations that accept relinquished equines were contacted to participate in a 90-question survey. Responding organizations (144 of 326 eligible) in 37 states provided information on 280 cases representative of the 7,990 horses relinquished between 2007 and 2009. Data collected characterized these organizations as being in existence for 6 yr, financially supported through donations and personal funds, dedicated to the care of only 10 to 20 horses on a property of just over 30 acres, and reliant on volunteers for help. Funding was the greatest challenge to continued operation of nonprofit equine organizations, with maintenance costs for the care of a relinquished horse averaging $3,648 per year. Financial hardship, physical inability, or lack of time to care for the horses by owners were the most common reasons for relinquishment, followed by seizure through law enforcement agencies for alleged neglect or abuse. Relinquished horses consisted of mostly light horse breeds (79.3%), with Thoroughbreds and Quarter Horses as the most represented breeds. The age of relinquished horses ranged from 3 d to 42 yr old (12.4 ± 0.5 yr). About one-half of the horses entered in the survey were considered unhealthy due to illness, injury, lameness, or poor body condition. For every 4 horses relinquished to a nonprofit organization, only 3 horses were adopted or sold between 2006 and 2009, and many organizations had refused to accept additional horses for lack of resources. The estimated maximum capacity for the 326

  17. Behind the scenes of GS: a professional fire and rescue service like no other

    CERN Multimedia

    Anaïs Schaeffer

    2014-01-01

    Meet the professionals at the top of their game working hard for the well-being of the CERN community. Meet the CERN Fire Brigade.   Highly-qualified professional firefighters CERN’s Fire and Rescue Service (FRS, GS-FB Group) currently consists of 58 professionals. These are highly sought-after positions: for just a handful of vacancies, hundreds of applications are submitted from all over Europe. And bear in mind that only professional firefighters with at least five years’ experience at a centre with high levels of operational activity may apply… and they must also have a good command of at least one of the Organization's two official languages. Once the pre-selection process is over, around twenty candidates progress to the next stage, where they are really put through their paces with language tests, theory exams and exercises on real fires. “For the practical part, all candidates are evaluated on their responses to a real fire," ...

  18. Rescue, Archival and Discovery of Tsunami Events on Marigrams

    Science.gov (United States)

    Eble, M. C.; Wright, L. M.; Stroker, K. J.; Sweeney, A.; Lancaster, M.

    2017-12-01

    The Big Earth Data Initiative made possible the reformatting of paper marigram records on which were recorded measurements of the 1946, 1952, 1960, and 1964 tsunamis generated in the Pacific Ocean. Data contained within each record were determined to be invaluable for tsunami researchers and operational agencies with a responsibility for issuing warnings during a tsunami event. All marigrams were carefully digitized and metadata were generated to form numerical datasets in order to provide the tsunami and other research and application-driven communities with quality data. Data were then packaged as CF-compliant netCDF datafiles and submitted to the NOAA Centers for Environmental Information for long-term stewardship, archival, and public discovery of both original scanned images and data in digital netCDF and CSC formats. The PNG plots of each time series were generated and included with data packages to provide a visual representation of the numerical data sets. ISO-compliant metadata were compiled for the collection at the event level and individual DOIs were minted for each of the four events included in this project. The procedure followed to reformat each record in this four-event subset of the larger NCEI scanned marigram inventory is presented and discussed. The practical use of these data is presented to highlight that even infrequent measurements of tsunamis hold information that may potentially help constrain earthquake rupture area, provide estimates of earthquake co-seismic slip distribution, identify subsidence or uplift, and significantly increase the holdings of situ data available for tsunami model validation. These same data may also prove valuable to the broader global tide community for validation and further development of tide models and for investigation into the stability of tidal harmonic constants. Data reformatted as part of this project are PARR compliant and meet the requirements for Data Management, Discoverability, Accessibility

  19. FEASIBILITY STUDY OF INEXPENSIVE THERMAL SENSORS AND SMALL UAS DEPLOYMENT FOR LIVING HUMAN DETECTION IN RESCUE MISSIONS APPLICATION SCENARIOS

    Directory of Open Access Journals (Sweden)

    E. Levin

    2016-06-01

    Full Text Available Significant efforts are invested by rescue agencies worldwide to save human lives during natural and man-made emergency situations including those that happen in wilderness locations. These emergency situations include but not limited to: accidents with alpinists, mountainous skiers, people hiking and lost in remote areas. Sometimes in a rescue operation hundreds of first responders are involved to save a single human life. There are two critical issues where geospatial imaging can be a very useful asset in rescue operations support: 1 human detection and 2 confirming a fact that detected a human being is alive. International group of researchers from the Unites States and Poland collaborated on a pilot research project devoted to identify a feasibility of use for the human detection and alive-human state confirmation small unmanned aerial vehicles (SUAVs and inexpensive forward looking infrared (FLIR sensors. Equipment price for both research teams was below $8,000 including 3DR quadrotor UAV and Lepton longwave infrared (LWIR imager which costs around $250 (for the US team; DJI Inspire 1 UAS with commercial Tamarisc-320 thermal camera (for the Polish team. Specifically both collaborating groups performed independent experiments in the USA and Poland and shared imaging data of on the ground and airborne electro-optical and FLIR sensor imaging collected. In these experiments dead bodies were emulated by use of medical training dummies. Real humans were placed nearby as live human subjects. Electro-optical imagery was used for the research in optimal human detection algorithms. Furthermore, given the fact that a dead human body after several hours has a temperature of the surrounding environment our experiments were challenged by the SUAS data optimization, i.e., distance from SUAV to object so that the FLIR sensor is still capable to distinguish temperature differences between a dummy and a real human. Our experiments indicated feasibility of

  20. CERN'S Fire and Rescue Group Gets New Ambulance

    CERN Multimedia

    2000-01-01

    The arrival of a new vehicle is always an important moment in the life of a fire station. So when a new ambulance was delivered to the CERN Fire Brigade on Wednesday 16 September 2000, it was given a warm welcome, attended by staff of the different divisions involved in its purchase. It took a year from the first administrative moves to the day of acquisition. On the one hand there were the calls for tender needed for such a purchase and on the other the development of this custom-designed ambulance with its unique features. Three visits to the manufacturer had to be made, including two to the head office of the Miesen factory at Bonn to study and incorporate in the ambulance the special requirements called for by its future users. These requirements, born from the past experience of CERN’s ambulance crews, concerned not only interior arrangements but also included a new side panel, opening up a stowage compartment where everything will be put that gets dirty during ambulance operations. This will minimize ...

  1. Coherent Operations, Entanglement, and Progress Toward Quantum Search in a Large 2D Array of Neutral Atom Qubits

    Science.gov (United States)

    2015-08-18

    by Benjamin Bederson and Herbert Walther, pp. 95 –170. issn: 1049-250X. doi: 10.1016/S1049-250X(08)60186-X. [49] Nicolas Schlosser, Georges Reymond...144 9.5.1.2 Genetic Algorithm . . . . . . . . . . . . . . . . . . . . . . . . 145 9.5.1.3 Nelder- Mead Simplex...from 2013-11-14-15-18-54. 90 Nelder- Mead optimizing readout frequency, power and time Readout frequency Iterations Python Controller Arroyo TEC and

  2. Market Dominance and Search Quality in the Search Engine Market

    NARCIS (Netherlands)

    Lianos, I.; Motchenkova, E.I.

    2013-01-01

    We analyze a search engine market from a law and economics perspective and incorporate the choice of quality-improving innovations by a search engine platform in a two-sided model of Internet search engine. In the proposed framework, we first discuss the legal issues the search engine market raises

  3. Mastering Search Analytics Measuring SEO, SEM and Site Search

    CERN Document Server

    Chaters, Brent

    2011-01-01

    Many companies still approach Search Engine Optimization (SEO) and paid search as separate initiatives. This in-depth guide shows you how to use these programs as part of a comprehensive strategy-not just to improve your site's search rankings, but to attract the right people and increase your conversion rate. Learn how to measure, test, analyze, and interpret all of your search data with a wide array of analytic tools. Gain the knowledge you need to determine the strategy's return on investment. Ideal for search specialists, webmasters, and search marketing managers, Mastering Search Analyt

  4. Rescue, rehabilitation, and release of marine mammals: An analysis of current views and practices.

    OpenAIRE

    St. Aubin, David J.; Geraci, Joseph R.; Lounsbury, Valerie J.

    1996-01-01

    Stranded marine mammals have long attracted public attention. Those that wash up dead are, for all their value to science, seldom seen by the public as more than curiosities. Animals that are sick, injured, orphaned or abandoned ignite a different response. Generally, public sentiment supports any effort to rescue, treat and return them to sea. Institutions displaying marine mammals showed an early interest in live-stranded animals as a source of specimens -- in 1948, Marine Studios in...

  5. Regulating Search Engines: Taking Stock And Looking Ahead

    OpenAIRE

    Gasser, Urs

    2006-01-01

    Since the creation of the first pre-Web Internet search engines in the early 1990s, search engines have become almost as important as email as a primary online activity. Arguably, search engines are among the most important gatekeepers in today's digitally networked environment. Thus, it does not come as a surprise that the evolution of search technology and the diffusion of search engines have been accompanied by a series of conflicts among stakeholders such as search operators, content crea...

  6. Mechanism of As2O3-Induced Action Potential Prolongation and Using hiPS-CMs to Evaluate the Rescue Efficacy of Drugs With Different Rescue Mechanism.

    Science.gov (United States)

    Yan, Meng; Feng, Lifang; Shi, Yanhui; Wang, Junnan; Liu, Yan; Li, Fengmei; Li, Baoxin

    2017-08-01

    Arsenic trioxide (As2O3) has been verified as a breakthrough in the management of acute promyelocytic leukemia in recent decades. However, cardiotoxicity, especially long QT syndrome (LQTS) has become the most important issue during As2O3 treatment. The characterized mechanisms behind this adverse effect are inhibition of cardiac hERG channel trafficking and increase of cardiac calcium currents. In our study, we found a new pathway underlying As2O3-induced cardiotoxicity that As2O3 accelerates lysosomal degradation of hERG on plasma membrane after using brefeldin A (BFA) to block protein trafficking. Then we explored pharmacological rescue strategies on As2O3-induced LQTS, and found that 4 therapeutic agents exert rescue efficacy via 3 different pathways: fexofenadine and astemizole facilitate hERG trafficking via promotion of channel-chaperone formation after As2O3 incubation; ranolazine slows hERG degradation in the presence of As2O3; and resveratrol shows significant attenuation on calcium current increase triggered by As2O3. Moreover, we used human-induced pluripotent stem cell derived cardiomyocytes (hiPS-CMs) to evaluate the rescue effects of the above agents on As2O3-induced prolongation of action potential duration (APD) and demonstrated that fexofenadine and resveratrol significantly ameliorate the prolonged APD. These observations suggested that pharmacological chaperone like fexofenadine and resveratrol might have the potential to protect against the cardiotoxicity of As2O3. © The Author 2017. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  7. Assessment and Comparison of Search capabilities of Web-based Meta-Search Engines: A Checklist Approach

    Directory of Open Access Journals (Sweden)

    Alireza Isfandiyari Moghadam

    2010-03-01

    Full Text Available   The present investigation concerns evaluation, comparison and analysis of search options existing within web-based meta-search engines. 64 meta-search engines were identified. 19 meta-search engines that were free, accessible and compatible with the objectives of the present study were selected. An author’s constructed check list was used for data collection. Findings indicated that all meta-search engines studied used the AND operator, phrase search, number of results displayed setting, previous search query storage and help tutorials. Nevertheless, none of them demonstrated any search options for hypertext searching and displaying the size of the pages searched. 94.7% support features such as truncation, keywords in title and URL search and text summary display. The checklist used in the study could serve as a model for investigating search options in search engines, digital libraries and other internet search tools.

  8. ADMINISTRATIVE CIRCULAR No. 25 (REV. 3) - Special provisions for the fire and rescue service governing working and rest time

    CERN Multimedia

    2012-01-01

    Administrative Circular No. 25 (Rev. 3) entitled “Special provisions for the Fire and Rescue Service governing working and rest time”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 28 September 2012 and entering into force in October 2012, is available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp This Circular is applicable to staff members of the Fire and Rescue Service It cancels and replaces Administrative Circular No. 25 (Rev. 2) entitled “Shift work – Special provisions for the Fire and Rescue Service” of April 2003. This new version takes into account the new organisation of the Fire and Rescue Service, members of which will henceforth not exclusively perform their functions in the context of shift work, but also during reference working hours and during stand-by duty. Additionally, applicable limits regarding working and rest times an...

  9. The emergence of the rescue effect from explicit within and between-patch dynamics in a metapopulation

    KAUST Repository

    Eriksson, Anders

    2014-02-12

    Immigration can rescue local populations from extinction, helping to stabilize a metapopulation. Local population dynamics is important for determining the strength of this rescue effect, but the mechanistic link between local demographic parameters and the rescue effect at the metapopulation level has received very little attention by modellers. We develop an analytical framework that allows us to describe the emergence of the rescue effect from interacting local stochastic dynamics. We show this framework to be applicable to a wide range of spatial scales, providing a powerful and convenient alternative to individual-based models for making predictions concerning the fate of metapopulations. We show that the rescue effect plays an important role in minimizing the increase in local extinction probability associated with high demographic stochasticity, but its role is more limited in the case of high local environmental stochasticity of recruitment or survival. While most models postulate the rescue effect, our framework provides an explicit mechanistic link between local dynamics and the emergence of the rescue effect, and more generally the stability of the whole metapopulation. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

  10. The emergence of the rescue effect from explicit within and between-patch dynamics in a metapopulation

    KAUST Repository

    Eriksson, Anders; Elí as-Wolff, Federico; Mehlig, Bernhard; Manica, Andrea

    2014-01-01

    Immigration can rescue local populations from extinction, helping to stabilize a metapopulation. Local population dynamics is important for determining the strength of this rescue effect, but the mechanistic link between local demographic parameters and the rescue effect at the metapopulation level has received very little attention by modellers. We develop an analytical framework that allows us to describe the emergence of the rescue effect from interacting local stochastic dynamics. We show this framework to be applicable to a wide range of spatial scales, providing a powerful and convenient alternative to individual-based models for making predictions concerning the fate of metapopulations. We show that the rescue effect plays an important role in minimizing the increase in local extinction probability associated with high demographic stochasticity, but its role is more limited in the case of high local environmental stochasticity of recruitment or survival. While most models postulate the rescue effect, our framework provides an explicit mechanistic link between local dynamics and the emergence of the rescue effect, and more generally the stability of the whole metapopulation. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

  11. Intermittent fasting uncovers and rescues cognitive phenotypes in PTEN neuronal haploinsufficient mice.

    Science.gov (United States)

    Cabral-Costa, J V; Andreotti, D Z; Mello, N P; Scavone, C; Camandola, S; Kawamoto, E M

    2018-06-05

    Phosphatase and tensin homolog (PTEN) is an important protein with key modulatory functions in cell growth and survival. PTEN is crucial during embryogenesis and plays a key role in the central nervous system (CNS), where it directly modulates neuronal development and synaptic plasticity. Loss of PTEN signaling function is associated with cognitive deficits and synaptic plasticity impairment. Accordingly, Pten mutations have a strong link with autism spectrum disorder. In this study, neuronal Pten haploinsufficient male mice were subjected to a long-term environmental intervention - intermittent fasting (IF) - and then evaluated for alterations in exploratory, anxiety and learning and memory behaviors. Although no significant effects on spatial memory were observed, mutant mice showed impaired contextual fear memory in the passive avoidance test - an outcome that was effectively rescued by IF. In this study, we demonstrated that IF modulation, in addition to its rescue of the memory deficit, was also required to uncover behavioral phenotypes otherwise hidden in this neuronal Pten haploinsufficiency model.

  12. The characters of emergency rescue and the measures to prevent accidents for nuclear-powered submarine

    International Nuclear Information System (INIS)

    Wang Yuexing

    1999-01-01

    The characteristics of emergency rescue and the measures for preventing and decreasing accidents in nuclear-powered submarine have been presented. The breakdown of equipment and human factors are the main reasons which lead to accidents. Four preventive measures are suggested: enhancing capabilities to take precautions against fire, seriously controlling the environmental factors which affect the health of the submariners, reinforcing the constitutions of the submariners, and working out emergency planning against serious accidents in advance

  13. Search Databases and Statistics

    DEFF Research Database (Denmark)

    Refsgaard, Jan C; Munk, Stephanie; Jensen, Lars J

    2016-01-01

    having strengths and weaknesses that must be considered for the individual needs. These are reviewed in this chapter. Equally critical for generating highly confident output datasets is the application of sound statistical criteria to limit the inclusion of incorrect peptide identifications from database...... searches. Additionally, careful filtering and use of appropriate statistical tests on the output datasets affects the quality of all downstream analyses and interpretation of the data. Our considerations and general practices on these aspects of phosphoproteomics data processing are presented here....

  14. Renal rescue of dopamine D2 receptor function reverses renal injury and high blood pressure

    Science.gov (United States)

    Konkalmatt, Prasad R.; Asico, Laureano D.; Zhang, Yanrong; Yang, Yu; Drachenberg, Cinthia; Zheng, Xiaoxu; Han, Fei; Jose, Pedro A.; Armando, Ines

    2016-01-01

    Dopamine D2 receptor (DRD2) deficiency increases renal inflammation and blood pressure in mice. We show here that long-term renal-selective silencing of Drd2 using siRNA increases renal expression of proinflammatory and profibrotic factors and blood pressure in mice. To determine the effects of renal-selective rescue of Drd2 expression in mice, the renal expression of DRD2 was first silenced using siRNA and 14 days later rescued by retrograde renal infusion of adeno-associated virus (AAV) vector with DRD2. Renal Drd2 siRNA treatment decreased the renal expression of DRD2 protein by 55%, and DRD2 AAV treatment increased the renal expression of DRD2 protein by 7.5- to 10-fold. Renal-selective DRD2 rescue reduced the expression of proinflammatory factors and kidney injury, preserved renal function, and normalized systolic and diastolic blood pressure. These results demonstrate that the deleterious effects of renal-selective Drd2 silencing on renal function and blood pressure were rescued by renal-selective overexpression of DRD2. Moreover, the deleterious effects of 45-minute bilateral ischemia/reperfusion on renal function and blood pressure in mice were ameliorated by a renal-selective increase in DRD2 expression by the retrograde ureteral infusion of DRD2 AAV immediately after the induction of ischemia/reperfusion injury. Thus, 14 days after ischemia/reperfusion injury, the renal expression of profibrotic factors, serum creatinine, and blood pressure were lower in mice infused with DRD2 AAV than in those infused with control AAV. These results indicate an important role of renal DRD2 in limiting renal injury and preserving normal renal function and blood pressure. PMID:27358912

  15. Rescue endoscopic bleeding control for nonvariceal upper gastrointestinal hemorrhage using clipping and detachable snaring.

    Science.gov (United States)

    Lee, J H; Kim, B K; Seol, D C; Byun, S J; Park, K H; Sung, I K; Park, H S; Shim, C S

    2013-06-01

    Nonvariceal upper gastrointestinal (UGI) bleeding recurs after appropriate endoscopic therapy in 10 % - 15 % of cases. The mortality rate can be as high as 25 % when bleeding recurs, but there is no consensus about the best modality for endoscopic re-treatment. The aim of this study was to evaluate clipping and detachable snaring (CDS) for rescue endoscopic control of nonvariceal UGI hemorrhage. We report a case series of seven patients from a Korean tertiary center who underwent endoscopic hemostasis using the combined method of detachable snares with hemoclips. The success rate of endoscopic hemostasis with CDS was 86 %: six of the seven patients who had experienced primary endoscopic treatment failure or recurrent bleeding after endoscopic hemostasis were treated successfully. In conclusion, rescue endoscopic bleeding control by means of CDS is an option for controlling nonvariceal UGI bleeding when no other method of endoscopic treatment for recurrent bleeding and primary hemostatic failure is possible. © Georg Thieme Verlag KG Stuttgart · New York.

  16. Social networking use and RescueTime: The issue of engagement

    OpenAIRE

    Collins, E.I.M.; Cox, A.L.; Bird, J.; Harrison, D.

    2014-01-01

    The dramatic rise in the use of social network sites (SNS) has resulted in a number of users feeling stressed about the extent of their personal use. Previous work has established that daily retrospective estimations of SNS use and access to RescueTime not only improve accuracy of estimations but also reduce perceived stress. The present study aimed to extend this by also exploring the influence of prospective estimations on stress and perceived time management. However, the study was thwarte...

  17. Human glia can both induce and rescue aspects of disease phenotype in Huntington disease

    DEFF Research Database (Denmark)

    Benraiss, Abdellatif; Wang, Su; Herrlinger, Stephanie

    2016-01-01

    The causal contribution of glial pathology to Huntington disease (HD) has not been heavily explored. To define the contribution of glia to HD, we established human HD glial chimeras by neonatally engrafting immunodeficient mice with mutant huntingtin (mHTT)-expressing human glial progenitor cells...... chimeras are hyperexcitable. Conversely, normal glia can ameliorate disease phenotype in transgenic HD mice, as striatal transplantation of normal glia rescues aspects of electrophysiological and behavioural phenotype, restores interstitial potassium homeostasis, slows disease progression and extends...

  18. The problem with rescue medicine.

    Science.gov (United States)

    Jecker, Nancy S

    2013-02-01

    Is there a rational and ethical basis for efforts to rescue individuals in dire straits? When does rescue have ethical support, and when does it reflect an irrational impulse? This paper defines a Rule of Rescue and shows its intuitive appeal. It then proceeds to argue that this rule lacks support from standard principles of justice and from ethical principles more broadly, and should be rejected in many situations. I distinguish between agent-relative and agent-neutral reasons, and argue that the Rule of Rescue qualifies only in a narrow range of cases where agent-relative considerations apply. I conclude that it would be wise to set aside the Rule of Rescue in many cases, especially those involving public policies, where it has only weak normative justification. The broader implications of this analysis are noted.

  19. Rescue US energy innovation

    Science.gov (United States)

    Anadon, Laura Diaz; Gallagher, Kelly Sims; Holdren, John P.

    2017-10-01

    President Trump has proposed severe cuts to US government spending on energy research, development and demonstration, but Congress has the `power of the purse' and can rescue US energy innovation. If serious cuts are enacted, the pace of innovation will slow, harming the economy, energy security and global environmental quality.

  20. THE UNITED RESCUE SYSTEM IN BULGARIA. CURRENT RESOURCE RELATED ISSUES AND PROSPECTIVE SOLUTIONS

    Directory of Open Access Journals (Sweden)

    Daniela Baleva

    2017-11-01

    Full Text Available The article presents some problems related to securing the Bulgarian system for disaster management with the necessary resources for its proper functioning. The main challenges for the united rescue system in the country are analyzed, including those related to ensuring the system with the necessary material, financial and human resources. Some possibilities for solving these problems with the use of funds from the European Union are presented.

  1. Search and Disrupt

    DEFF Research Database (Denmark)

    Ørding Olsen, Anders

    . However, incumbent sources engaged in capability reconfiguration to accommodate disruption improve search efforts in disruptive technologies. The paper concludes that the value of external sources is contingent on more than their knowledge. Specifically, interdependence of sources in search gives rise...... to influence from individual strategic interests on the outcomes. More generally, this points to the need for understanding the two-way influence of sources, rather than viewing external search as one-way knowledge accessing....

  2. Using Google Earth in Marine Research and Operational Decision Support

    Science.gov (United States)

    Blower, J. D.; Bretherton, D.; Haines, K.; Liu, C.; Rawlings, C.; Santokhee, A.; Smith, I.

    2006-12-01

    A key advantage of Virtual Globes ("geobrowsers") such as Google Earth is that they can display many different geospatial data types at a huge range of spatial scales. In this demonstration and poster display we shall show how marine data from disparate sources can be brought together in a geobrowser in order to support both scientific research and operational search and rescue activities. We have developed the Godiva2 interactive website for browsing and exploring marine data, mainly output from supercomputer analyses and predictions of ocean circulation. The user chooses a number of parameters (e.g. sea temperature at 100m depth on 1st July 2006) and can load an image of the resulting data in Google Earth. Through the use of an automatically-refreshing NetworkLink the user can explore the whole globe at a very large range of spatial scales: the displayed data will automatically be refreshed to show data at increasingly fine resolution as the user zooms in. This is a valuable research tool for exploring these terabyte- scale datasets. Many coastguard organizations around the world use SARIS, a software application produced by BMT Cordah Ltd., to predict the drift pattern of objects in the sea in order to support search and rescue operations. Different drifting objects have different trajectories depending on factors such as their buoyancy and windage and so a computer model, supported by meteorological and oceanographic data, is needed to help rescuers locate their targets. We shall demonstrate how Google Earth is used to display output from the SARIS model (including the search target location and associated error polygon) alongside meteorological data (wind vectors) and oceanographic data (sea temperature, surface currents) from Godiva2 in order to support decision-making. We shall also discuss the limitations of using Google Earth in this context: these include the difficulties of working with time- dependent data and the need to access data securely. essc

  3. Inversion for Refractivity Parameters Using a Dynamic Adaptive Cuckoo Search with Crossover Operator Algorithm

    Directory of Open Access Journals (Sweden)

    Zhihua Zhang

    2016-01-01

    Full Text Available Using the RFC technique to estimate refractivity parameters is a complex nonlinear optimization problem. In this paper, an improved cuckoo search (CS algorithm is proposed to deal with this problem. To enhance the performance of the CS algorithm, a parameter dynamic adaptive operation and crossover operation were integrated into the standard CS (DACS-CO. Rechenberg’s 1/5 criteria combined with learning factor were used to control the parameter dynamic adaptive adjusting process. The crossover operation of genetic algorithm was utilized to guarantee the population diversity. The new hybrid algorithm has better local search ability and contributes to superior performance. To verify the ability of the DACS-CO algorithm to estimate atmospheric refractivity parameters, the simulation data and real radar clutter data are both implemented. The numerical experiments demonstrate that the DACS-CO algorithm can provide an effective method for near-real-time estimation of the atmospheric refractivity profile from radar clutter.

  4. Inversion for Refractivity Parameters Using a Dynamic Adaptive Cuckoo Search with Crossover Operator Algorithm.

    Science.gov (United States)

    Zhang, Zhihua; Sheng, Zheng; Shi, Hanqing; Fan, Zhiqiang

    2016-01-01

    Using the RFC technique to estimate refractivity parameters is a complex nonlinear optimization problem. In this paper, an improved cuckoo search (CS) algorithm is proposed to deal with this problem. To enhance the performance of the CS algorithm, a parameter dynamic adaptive operation and crossover operation were integrated into the standard CS (DACS-CO). Rechenberg's 1/5 criteria combined with learning factor were used to control the parameter dynamic adaptive adjusting process. The crossover operation of genetic algorithm was utilized to guarantee the population diversity. The new hybrid algorithm has better local search ability and contributes to superior performance. To verify the ability of the DACS-CO algorithm to estimate atmospheric refractivity parameters, the simulation data and real radar clutter data are both implemented. The numerical experiments demonstrate that the DACS-CO algorithm can provide an effective method for near-real-time estimation of the atmospheric refractivity profile from radar clutter.

  5. Heuristic Search Theory and Applications

    CERN Document Server

    Edelkamp, Stefan

    2011-01-01

    Search has been vital to artificial intelligence from the very beginning as a core technique in problem solving. The authors present a thorough overview of heuristic search with a balance of discussion between theoretical analysis and efficient implementation and application to real-world problems. Current developments in search such as pattern databases and search with efficient use of external memory and parallel processing units on main boards and graphics cards are detailed. Heuristic search as a problem solving tool is demonstrated in applications for puzzle solving, game playing, constra

  6. Race and time from diagnosis to radical prostatectomy: does equal access mean equal timely access to the operating room?--Results from the SEARCH database.

    Science.gov (United States)

    Bañez, Lionel L; Terris, Martha K; Aronson, William J; Presti, Joseph C; Kane, Christopher J; Amling, Christopher L; Freedland, Stephen J

    2009-04-01

    African American men with prostate cancer are at higher risk for cancer-specific death than Caucasian men. We determine whether significant delays in management contribute to this disparity. We hypothesize that in an equal-access health care system, time interval from diagnosis to treatment would not differ by race. We identified 1,532 African American and Caucasian men who underwent radical prostatectomy (RP) from 1988 to 2007 at one of four Veterans Affairs Medical Centers that comprise the Shared Equal-Access Regional Cancer Hospital (SEARCH) database with known biopsy date. We compared time from biopsy to RP between racial groups using linear regression adjusting for demographic and clinical variables. We analyzed risk of potential clinically relevant delays by determining odds of delays >90 and >180 days. Median time interval from diagnosis to RP was 76 and 68 days for African Americans and Caucasian men, respectively (P = 0.004). After controlling for demographic and clinical variables, race was not associated with the time interval between diagnosis and RP (P = 0.09). Furthermore, race was not associated with increased risk of delays >90 (P = 0.45) or >180 days (P = 0.31). In a cohort of men undergoing RP in an equal-access setting, there was no significant difference between racial groups with regard to time interval from diagnosis to RP. Thus, equal-access includes equal timely access to the operating room. Given our previous finding of poorer outcomes among African Americans, treatment delays do not seem to explain these observations. Our findings need to be confirmed in patients electing other treatment modalities and in other practice settings.

  7. Physical capacity of rescue personnel in the mining industry

    Directory of Open Access Journals (Sweden)

    Hunt Andrew P

    2008-10-01

    Full Text Available Abstract Background The mining industry has one of the highest occupational rates of serious injury and fatality. Mine staff involved with rescue operations are often required to respond to physically challenging situations. This paper describes the physical attributes of mining rescue personnel. Methods 91 rescue personnel (34 ± 8.6 yrs, 1.79 ± 0.07 m, 90 ± 15.0 kg participating in the Queensland Mines Rescue Challenge completed a series of health-related and rescue-related fitness tasks. Health-related tasks comprised measurements of aerobic capacity (VO2max, abdominal endurance, abdominal strength, flexibility, lower back strength, leg strength, elbow flexion strength, shoulder strength, lower back endurance, and leg endurance. Rescue-related tasks comprised an incremental carry (IC, coal shovel (CS, and a hose drag (HD, completed in this order. Results Cardiovascular (VO2max and muscular endurance was average or below average compared with the general population. Isometric strength did not decline with age. The rescue-related tasks were all extremely demanding with heart rate responses averaging greater than 88% of age predicted maximal heart rates. Heart rate recovery responses were more discriminating than heart rates recorded during the tasks, indicating the hose drag as the most physically demanding of the tasks. Conclusion Relying on actual rescues or mining related work to provide adequate training is generally insufficient to maintain, let alone increase, physical fitness. It is therefore recommended that standards of required physical fitness be developed and mines rescue personnel undergo regularly training (and assessment in order to maintain these standards.

  8. Autonomous search and surveillance with small fixed wing aircraft

    Science.gov (United States)

    McGee, Timothy Garland

    Small unmanned aerial vehicles (UAVs) have the potential to act as low cost tools in a variety of both civilian and military applications including traffic monitoring, border patrol, and search and rescue. While most current operational UAV systems require human operators, advances in autonomy will allow these systems to reach their full potential as sensor platforms. This dissertation specifically focuses on developing advanced control, path planning, search, and image processing techniques that allow small fixed wing aircraft to autonomously collect data. The problems explored were motivated by experience with the development and experimental flight testing of a fleet of small autonomous fixed wing aircraft. These issues, which have not been fully addressed in past work done on ground vehicles or autonomous helicopters, include the influence of wind and turning rate constraints, the non-negligible velocity of ground targets relative to the aircraft velocity, and limitations on sensor size and processing power on small vehicles. Several contributions for the autonomous operation of small fixed wing aircraft are presented. Several sliding surface controllers are designed which extend previous techniques to include variable sliding surface coefficients and the use of spatial vehicle dynamics. These advances eliminate potential singularities in the control laws to follow spatially defined paths and allow smooth transition between controllers. The optimal solution for the problem of path planning through an ordered set of points for an aircraft with a bounded turning rate in the presence of a constant wind is then discussed. Path planning strategies are also explored to guarantee that a searcher will travel within sensing distance of a mobile ground target. This work assumes only a maximum velocity of the target and is designed to succeed for any possible path of the target. Closed-loop approximations of both the path planning and search techniques, using the sliding

  9. Search costs and efficiency : Do unemployed workers search enough?

    NARCIS (Netherlands)

    Gautier, Pieter A.; Moraga González, José; Wolthoff, Ronald P.

    Many labor market policies affect the marginal benefits and costs of job search. The impact and desirability of such policies depend on the distribution of search costs. In this paper, we provide an equilibrium framework for identifying the distribution of search costs and we apply it to the Dutch

  10. Mid-Term report 'Establishing bonds for the advancement of the Rescue League'

    NARCIS (Netherlands)

    Riaño, I.; Visser, A.

    2014-01-01

    The RoboCup Rescue Simulation League aims to benchmark the intelligence of software agents and robots on their capabilities to make autonomously the right decisions in a disaster response scenario. The UvA Rescue and Distribot team have come together to work co-operatively to support this aim in two

  11. Final report 'Establishing bonds for the advancement of the Rescue League'

    NARCIS (Netherlands)

    Riaño, I.; Visser, A.

    2014-01-01

    The RoboCup Rescue Simulation League aims to benchmark the intelligence of software agents and robots on their capabilities to make autonomously the right decisions in a disaster response scenario. The UvA Rescue and Distribot team have come together to work co-operatively to support this aim in two

  12. Rescuing Tomorrow Today: Fixing Training and Development for DHS Leaders

    Science.gov (United States)

    2016-09-01

    their own ideas, qualifications, and contributions and not jump to conclusions based on stereotypes .”23 A poor leader or organization will try and...experienced riots that the media portrayed as race-related. However, the underlying cause was actually senior leadership’s inability to control ship...overall scope, the Navy has shifted its focus to other modes and media for training.132 Command-based training and computer-based training are

  13. Rescuing drug discovery: In vivo systems pathology and systems pharmacology

    NARCIS (Netherlands)

    Greef, J. van der; McBurney, R.N.

    2005-01-01

    The pharmaceutical industry is currently beleaguered by close scrutiny from the financial community, regulators and the general public. Productivity, in terms of new drug approvals, has generally been falling for almost a decade and the safety of a number of highly successful drugs has recently been

  14. Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine

    Directory of Open Access Journals (Sweden)

    Luciano Rezende Vilela

    2015-01-01

    Full Text Available Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality. The most severe and common complications are seizures, ischemic strokes, myocardial infarction, and acute liver injury. Here, we demonstrated that acute cocaine intoxication promoted seizure along with acute liver damage in mice, with intense inflammatory infiltrate. Considering the protective role of the endocannabinoid system against cell toxicity, we hypothesized that treatment with an anandamide hydrolysis inhibitor, URB597, or with a phytocannabinoid, cannabidiol (CBD, protects against cocaine toxicity. URB597 (1.0 mg/kg abolished cocaine-induced seizure, yet it did not protect against acute liver injury. Using confocal liver intravital microscopy, we observed that CBD (30 mg/kg reduced acute liver inflammation and damage induced by cocaine and prevented associated seizure. Additionally, we showed that previous liver damage induced by another hepatotoxic drug (acetaminophen increased seizure and lethality induced by cocaine intoxication, linking hepatotoxicity to seizure dynamics. These findings suggest that activation of cannabinoid system may have protective actions on both liver and brain induced by cocaine, minimizing inflammatory injury promoted by cocaine, supporting its further clinical application in the treatment of cocaine abuse.

  15. Effects of Clonal Reproduction on Evolutionary Lag and Evolutionary Rescue.

    Science.gov (United States)

    Orive, Maria E; Barfield, Michael; Fernandez, Carlos; Holt, Robert D

    2017-10-01

    Evolutionary lag-the difference between mean and optimal phenotype in the current environment-is of keen interest in light of rapid environmental change. Many ecologically important organisms have life histories that include stage structure and both sexual and clonal reproduction, yet how stage structure and clonality interplay to govern a population's rate of evolution and evolutionary lag is unknown. Effects of clonal reproduction on mean phenotype partition into two portions: one that is phenotype dependent, and another that is genotype dependent. This partitioning is governed by the association between the nonadditive genetic plus random environmental component of phenotype of clonal offspring and their parents. While clonality slows phenotypic evolution toward an optimum, it can dramatically increase population survival after a sudden step change in optimal phenotype. Increased adult survival slows phenotypic evolution but facilitates population survival after a step change; this positive effect can, however, be lost given survival-fecundity trade-offs. Simulations indicate that the benefits of increased clonality under environmental change greatly depend on the nature of that change: increasing population persistence under a step change while decreasing population persistence under a continuous linear change requiring de novo variation. The impact of clonality on the probability of persistence for species in a changing world is thus inexorably linked to the temporal texture of the change they experience.

  16. The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model

    Directory of Open Access Journals (Sweden)

    Ben-Shachar Rotem

    2012-12-01

    Full Text Available Abstract Background Acetaminophen (N-acetyl-para-aminophenol is the most widely used over-the-counter or prescription painkiller in the world. Acetaminophen is metabolized in the liver where a toxic byproduct is produced that can be removed by conjugation with glutathione. Acetaminophen overdoses, either accidental or intentional, are the leading cause of acute liver failure in the United States, accounting for 56,000 emergency room visits per year. The standard treatment for overdose is N-acetyl-cysteine (NAC, which is given to stimulate the production of glutathione. Methods We have created a mathematical model for acetaminophen transport and metabolism including the following compartments: gut, plasma, liver, tissue, urine. In the liver compartment the metabolism of acetaminophen includes sulfation, glucoronidation, conjugation with glutathione, production of the toxic metabolite, and liver damage, taking biochemical parameters from the literature whenever possible. This model is then connected to a previously constructed model of glutathione metabolism. Results We show that our model accurately reproduces published clinical and experimental data on the dose-dependent time course of acetaminophen in the plasma, the accumulation of acetaminophen and its metabolites in the urine, and the depletion of glutathione caused by conjugation with the toxic product. We use the model to study the extent of liver damage caused by overdoses or by chronic use of therapeutic doses, and the effects of polymorphisms in glucoronidation enzymes. We use the model to study the depletion of glutathione and the effect of the size and timing of N-acetyl-cysteine doses given as an antidote. Our model accurately predicts patient death or recovery depending on size of APAP overdose and time of treatment. Conclusions The mathematical model provides a new tool for studying the effects of various doses of acetaminophen on the liver metabolism of acetaminophen and

  17. In vitro embryo rescue and plant regeneration following self ...

    African Journals Online (AJOL)

    EJIRO

    2015-07-08

    Jul 8, 2015 ... calculated using the simple matching Euclidean distance (DE) followed by cluster analysis ..... we plan to fully characterize these plantlets and to establish whether or not .... Tesis de Grado, Universidad. ICESI, Cali. Colombia.

  18. Submarine Rescue. Mooring and Salvage Ships of the Soviet Navy,

    Science.gov (United States)

    1983-07-13

    motion after they strike the surface of the water, because of which they are carried away from the ship and can no longer endanger the ship. Only four of...they have a characteristic icebreaker bow, while the others have a protruding bulb at the forefoot . Above the waterline - aside from the completely

  19. civil-military relations in disaster rescue and relief activities

    African Journals Online (AJOL)

    Abel

    same fashion, the Guidelines also assert that it is primarily the obligation of the affected ... Although seen as a 'last resort' and a temporary measure, the underlying ... Given the regularity of such typical disasters, it has also been a trend for the.

  20. Multimedia Search Engines : Concept, Performance, and Types

    OpenAIRE

    Sayed Rabeh Sayed

    2005-01-01

    A Research about multimedia search engines, it starts with definition of search engines at general and multimedia search engines, then explains how they work, and divided them into: Video search engines, Images search engines, and Audio search engines. Finally, it reviews a samples to multimedia search engines.

  1. XBT profilers for operational purposes: application and validation in real exercises

    Directory of Open Access Journals (Sweden)

    Francisco Machín

    2008-12-01

    Full Text Available A methodology for recovering salinity from expendable bathythermograph (XBT data is presented. The procedure exploits climatological relationships between temperature, salinity and depth to build regional characteristic curves by fitting a polynomial function that minimises both the variance of residuals and unknowns. Hence, salinity is computed and recovered as a function of temperature and depth. Empirical formula are provided to recover the salinity field from temperature-depth measurements for the Cantabrian Sea and Galician Area. The method is validated and applied in the context of two marine rescue exercises carried out in the Bay of Biscay close to the north coast of Spain and in the Finisterre region, where a series of XBT and conductivity-temperature-depth (CTD profiles were acquired during fast samplings. The results agree reasonably well with independent data in terms of the spatial structure, with the largest errors in the upper 100 m of the ocean and at intermediate levels. The first diagnoses of the surface geostrophic velocity fields obtained through the salinity reconstruction are coherent and may help in rescue and safety operations during marine emergencies. Hence, we recommend that a technical unit should consider this kind of expandable sampling strategy with both XBT and XCTD data during marine emergencies, since it provides useful and comprehensive information rapidly with minimal interference by means of formal operations on board search and rescue ships.

  2. Search and nonsearch protocols for radiographic consultation

    International Nuclear Information System (INIS)

    Swensson, R.G.; Theodore, G.H.

    1989-01-01

    Six radiologists, acting as film reviewers, used two different consultation protocols to differentiate among 292 ambiguous findings on chest films: 120 simulated nodules and 172 normal findings (previous readers' false-positive reports of nodules). The non-search protocol identified each finding (by location), and reviewers rated its likelihood as a nodule. The search protocol, which asked reviewers to report and rate all locations regarded as possible nodules on each film, assigned a default negative rating to any unreported finding (nodule or normal). Receiver operator characteristic analyses demonstrated a significantly higher accuracy for each reviewer's search- protocol discriminations between these nodules and confusing normal findings

  3. A learning-based semi-autonomous controller for robotic exploration of unknown disaster scenes while searching for victims.

    Science.gov (United States)

    Doroodgar, Barzin; Liu, Yugang; Nejat, Goldie

    2014-12-01

    Semi-autonomous control schemes can address the limitations of both teleoperation and fully autonomous robotic control of rescue robots in disaster environments by allowing a human operator to cooperate and share such tasks with a rescue robot as navigation, exploration, and victim identification. In this paper, we present a unique hierarchical reinforcement learning-based semi-autonomous control architecture for rescue robots operating in cluttered and unknown urban search and rescue (USAR) environments. The aim of the controller is to enable a rescue robot to continuously learn from its own experiences in an environment in order to improve its overall performance in exploration of unknown disaster scenes. A direction-based exploration technique is integrated in the controller to expand the search area of the robot via the classification of regions and the rubble piles within these regions. Both simulations and physical experiments in USAR-like environments verify the robustness of the proposed HRL-based semi-autonomous controller to unknown cluttered scenes with different sizes and varying types of configurations.

  4. Cancer’s Achilles’ Heel: Apoptosis and Necroptosis to the Rescue

    Directory of Open Access Journals (Sweden)

    Atreyi Dasgupta

    2016-12-01

    Full Text Available Apoptosis, and the more recently discovered necroptosis, are two avenues of programmed cell death. Cancer cells survive by evading these two programs, driven by oncogenes and tumor suppressor genes. While traditional therapy using small molecular inhibitors and chemotherapy are continuously being utilized, a new and exciting approach is actively underway by identifying and using synergistic relationship between driver and rescue genes in a cancer cell. Through these synthetic lethal relationships, we are gaining tremendous insights into tumor vulnerabilities and specific molecular avenues for induction of programmed cell death. In this review, we briefly discuss the two cell death processes and cite examples of such synergistic manipulations for therapeutic purposes.

  5. Enhancing dopaminergic signaling and histone acetylation promotes long-term rescue of deficient fear extinction

    Science.gov (United States)

    Whittle, N; Maurer, V; Murphy, C; Rainer, J; Bindreither, D; Hauschild, M; Scharinger, A; Oberhauser, M; Keil, T; Brehm, C; Valovka, T; Striessnig, J; Singewald, N

    2016-01-01

    Extinction-based exposure therapy is used to treat anxiety- and trauma-related disorders; however, there is the need to improve its limited efficacy in individuals with impaired fear extinction learning and to promote greater protection against return-of-fear phenomena. Here, using 129S1/SvImJ mice, which display impaired fear extinction acquisition and extinction consolidation, we revealed that persistent and context-independent rescue of deficient fear extinction in these mice was associated with enhanced expression of dopamine-related genes, such as dopamine D1 (Drd1a) and -D2 (Drd2) receptor genes in the medial prefrontal cortex (mPFC) and amygdala, but not hippocampus. Moreover, enhanced histone acetylation was observed in the promoter of the extinction-regulated Drd2 gene in the mPFC, revealing a potential gene-regulatory mechanism. Although enhancing histone acetylation, via administering the histone deacetylase (HDAC) inhibitor MS-275, does not induce fear reduction during extinction training, it promoted enduring and context-independent rescue of deficient fear extinction consolidation/retrieval once extinction learning was initiated as shown following a mild conditioning protocol. This was associated with enhanced histone acetylation in neurons of the mPFC and amygdala. Finally, as a proof-of-principle, mimicking enhanced dopaminergic signaling by L-dopa treatment rescued deficient fear extinction and co-administration of MS-275 rendered this effect enduring and context-independent. In summary, current data reveal that combining dopaminergic and epigenetic mechanisms is a promising strategy to improve exposure-based behavior therapy in extinction-impaired individuals by initiating the formation of an enduring and context-independent fear-inhibitory memory. PMID:27922638

  6. A Review of Mine Rescue Ensembles for Underground Coal Mining in the United States.

    Science.gov (United States)

    Kilinc, F Selcen; Monaghan, William D; Powell, Jeffrey B

    The mining industry is among the top ten industries nationwide with high occupational injury and fatality rates, and mine rescue response may be considered one of the most hazardous activities in mining operations. In the aftermath of an underground mine fire, explosion or water inundation, specially equipped and trained teams have been sent underground to fight fires, rescue entrapped miners, test atmospheric conditions, investigate the causes of the disaster, or recover the dead. Special personal protective ensembles are used by the team members to improve the protection of rescuers against the hazards of mine rescue and recovery. Personal protective ensembles used by mine rescue teams consist of helmet, cap lamp, hood, gloves, protective clothing, boots, kneepads, facemask, breathing apparatus, belt, and suspenders. While improved technology such as wireless warning and communication systems, lifeline pulleys, and lighted vests have been developed for mine rescuers over the last 100 years, recent research in this area of personal protective ensembles has been minimal due to the trending of reduced exposure of rescue workers. In recent years, the exposure of mine rescue teams to hazardous situations has been changing. However, it is vital that members of the teams have the capability and proper protection to immediately respond to a wide range of hazardous situations. Currently, there are no minimum requirements, best practice documents, or nationally recognized consensus standards for protective clothing used by mine rescue teams in the United States (U.S.). The following review provides a summary of potential issues that can be addressed by rescue teams and industry to improve potential exposures to rescue team members should a disaster situation occur. However, the continued trending in the mining industry toward non-exposure to potential hazards for rescue workers should continue to be the primary goal. To assist in continuing this trend, the mining industry

  7. Helicobacter pylori first-line and rescue treatments in the presence of penicillin allergy.

    Science.gov (United States)

    Gisbert, Javier P; Barrio, Jesús; Modolell, Inés; Molina-Infante, Javier; Aisa, Angeles Perez; Castro-Fernández, Manuel; Rodrigo, Luis; Cosme, Angel; Gisbert, Jose Luis; Fernández-Bermejo, Miguel; Marcos, Santiago; Marín, Alicia C; McNicholl, Adrián G

    2015-02-01

    Helicobacter pylori eradication is a challenge in penicillin allergy. To assess the efficacy and safety of first-line and rescue treatments in patients allergic to penicillin. Prospective multicenter study. Patients allergic to penicillin were given a first-line treatment comprising (a) 7-day omeprazole-clarithromycin-metronidazole and (b) 10-day omeprazole-bismuth-tetracycline-metronidazole. Rescue treatments were as follows: (a) bismuth quadruple therapy; (b) 10-day PPI-clarithromycin-levofloxacin; and (c) 10-day PPI-clarithromycin-rifabutin. Eradication was confirmed by (13)C-urea breath test. Compliance was determined through questioning and recovery of empty medication envelopes. Adverse effects were evaluated by questionnaires. In total, 267 consecutive treatments were included. (1) First-line treatment: Per-protocol and intention-to-treat eradication rates with omeprazole-clarithromycin-metronidazole were 59 % (62/105; 95 % CI 49-62 %) and 57 % (64/112; 95 % CI 47-67 %). Respective figures for PPI-bismuth-tetracycline-metronidazole were 75 % (37/49; 95 % CI 62-89 %) and 74 % (37/50; 95 % CI (61-87 %) (p failure; compliance was 88-100 %, with 23-29 % adverse effects (all mild). (3) Third-/fourth-line treatment: Intention-to-treat eradication rate with PPI-clarithromycin-rifabutin was 22 %. In allergic to penicillin patients, a first-line treatment with a bismuth-containing quadruple therapy (PPI-bismuth-tetracycline-metronidazole) seems to be a better option than the triple PPI-clarithromycin-metronidazole regimen. A levofloxacin-based regimen (together with a PPI and clarithromycin) represents a second-line rescue option in the presence of penicillin allergy.

  8. LHCb Exotica and Higgs searches

    CERN Multimedia

    Lucchesi, Donatella

    2016-01-01

    The unique phase space coverage and features of the LHCb detector at the LHC makes it an ideal environment to probe complementary New Physics parameter regions. In particular, recently developed jet tagging algorithms are ideal for searches involving $b$ and $c$ jets. This poster will review different jet-related exotica searches together with the efforts in the search for a Higgs boson decaying to a pair of heavy quarks.

  9. Melatonin rescues cardiovascular dysfunction during hypoxic development in the chick embryo

    OpenAIRE

    Itani, Nozomi; Skeffington, Katie L.; Beck, Christian; Niu, Youguo; Giussani, Dino A.

    2015-01-01

    Abstract There is a search for rescue therapy against fetal origins of cardiovascular disease in pregnancy complicated by chronic fetal hypoxia, particularly following clinical diagnosis of fetal growth restriction (FGR). Melatonin protects the placenta in adverse pregnancy; however, whether melatonin protects the fetal heart and vasculature in hypoxic pregnancy independent of effects on the placenta is unknown. Whether melatonin can rescue fetal cardiovascular dysfunction when treatment comm...

  10. Collective search by ants in microgravity

    Directory of Open Access Journals (Sweden)

    Stefanie M. Countryman

    2015-03-01

    Full Text Available The problem of collective search is a tradeoff between searching thoroughly and covering as much area as possible. This tradeoff depends on the density of searchers. Solutions to the problem of collective search are currently of much interest in robotics and in the study of distributed algorithms, for example to design ways that without central control robots can use local information to perform search and rescue operations. Ant colonies operate without central control. Because they can perceive only local, mostly chemical and tactile cues, they must search collectively to find resources and to monitor the colony's environment. Examining how ants in diverse environments solve the problem of collective search can elucidate how evolution has led to diverse forms of collective behavior. An experiment on the International Space Station in January 2014 examined how ants (Tetramorium caespitum perform collective search in microgravity. In the ISS experiment, the ants explored a small arena in which a barrier was lowered to increase the area and thus lower ant density. In microgravity, relative to ground controls, ants explored the area less thoroughly and took more convoluted paths. It appears that the difficulty of holding on to the surface interfered with the ants’ ability to search collectively. Ants frequently lost contact with the surface, but showed a remarkable ability to regain contact with the surface.

  11. Emergency Air Rescue System in Romania

    Directory of Open Access Journals (Sweden)

    Tranca Sebastian

    2018-03-01

    Full Text Available The helicopter, as a means of transport, has facilitated a significant decrease in intervention time at the site of request, increasing the chances of survival of the critical patient. Since 2003, SMURD has managed to form a fleet composed of nine helicopters and two airplanes. From an operational and strategic point of view, the SMURD intervention unit, set up seven Aeromedical Operational Bases (A.O.B. equipped with helicopters and materials necessary for their operation. There is a dynamic increase in the number of air rescue missions in Romania, with most missions being carried out by the air rescue bases in Târgu Mureş and Bucharest. Specialty literature has clearly demonstrated the positive impact on the survival of critical patients assisted by airborne crews, so it is necessary for the Romanian air rescue system to grow up. It is necessary to increase the number of air bases, purchase new helicopters and to continue the training programs of both pilots and medical personnel.

  12. Beyond the search surface: visual search and attentional engagement.

    Science.gov (United States)

    Duncan, J; Humphreys, G

    1992-05-01

    Treisman (1991) described a series of visual search studies testing feature integration theory against an alternative (Duncan & Humphreys, 1989) in which feature and conjunction search are basically similar. Here the latter account is noted to have 2 distinct levels: (a) a summary of search findings in terms of stimulus similarities, and (b) a theory of how visual attention is brought to bear on relevant objects. Working at the 1st level, Treisman found that even when similarities were calibrated and controlled, conjunction search was much harder than feature search. The theory, however, can only really be tested at the 2nd level, because the 1st is an approximation. An account of the findings is developed at the 2nd level, based on the 2 processes of input-template matching and spreading suppression. New data show that, when both of these factors are controlled, feature and conjunction search are equally difficult. Possibilities for unification of the alternative views are considered.

  13. Pain, health perception and sleep: impact on the quality of life of firefighters/rescue professionals

    Directory of Open Access Journals (Sweden)

    Rafael Silva Marconato

    2015-12-01

    Full Text Available Objective: to evaluate the quality of life of firefighters and rescue professionals, and characterize their socio-demographic, health, work and lifestyle profile. Methods: cross-sectional study that used a socio-demographic, lifestyle, health, work data questionnaire and the WHOQOL-BREF quality of life aspects, in Fire Department bases, Civil Air Patrol Group of the Military Police and Rescue Group of Emergency Services. Results: ninety professionals participated in this study - 71 firefighters, 9 nurses, 7 doctors and 3 flight crew members. The average age of the group was 36.4 ± 7.8 years; they worked about 63.7 hours per week; 20.2% reported pain in the last week and 72.7% had body mass index above 25 kg/m2. The average of the WHOQOL-BREF domains was: physical (74.6, psychological (75.2, social (76.5 and environmental (58.7. Significant association was found (Mann-Whitney test and Spearman correlation between the WHOQOL-BREF domains and pain in the past six months, in the last week, health perception, job satisfaction, hours of sleep, domestic tasks and study. Conclusion: the main factors related to quality of life were presence of pain, health perception, sleep and domestic activity.

  14. Pain, health perception and sleep: impact on the quality of life of firefighters/rescue professionals.

    Science.gov (United States)

    Marconato, Rafael Silva; Monteiro, Maria Ines

    2015-01-01

    To evaluate the quality of life of firefighters and rescue professionals, and characterize their socio-demographic, health, work and lifestyle profile. Cross-sectional study that used a socio-demographic, lifestyle, health, work data questionnaire and the WHOQOL-BREF quality of life aspects, in Fire Department bases, Civil Air Patrol Group of the Military Police and Rescue Group of Emergency Services. Ninety professionals participated in this study - 71 firefighters, 9 nurses, 7 doctors and 3 flight crew members. The average age of the group was 36.4 ± 7.8 years; they worked about 63.7 hours per week; 20.2% reported pain in the last week and 72.7% had body mass index above 25 kg/m2. The average of the WHOQOL-BREF domains was: physical (74.6), psychological (75.2), social (76.5) and environmental (58.7). Significant association was found (Mann-Whitney test and Spearman correlation) between the WHOQOL-BREF domains and pain in the past six months, in the last week, health perception, job satisfaction, hours of sleep, domestic tasks and study. The main factors related to quality of life were presence of pain, health perception, sleep and domestic activity.

  15. Stereotypical Behaviors in Chimpanzees Rescued from the African Bushmeat and Pet Trade

    Directory of Open Access Journals (Sweden)

    Ashlynn Dube

    2012-12-01

    Full Text Available Many orphaned chimpanzees whose mothers are illegally killed for their meat (bushmeat in Africa are sold as pets or kept caged at hotels and businesses to attract tourists. As a result of being separated from their mothers and other chimpanzees at an early age, and spending years in impoverished captive conditions, some of these individuals engage in abnormal behaviors, including stereotypically scratching at their flesh and repetitively rocking back and forth. This paper presents case studies of Poco and Safari, two chimpanzees who were rescued by sanctuaries after living alone on display for humans at businesses for the first 7 to 8 years of their lives. Decades after their rescue, they still engage in stereotypical behaviors as a result of the psychological and physical trauma they endured early on. This paper combines data from in depth interviews with caregivers and direct observations of abnormal behaviors to assess psychological distress in captive-living chimpanzees. Our results highlight some lesser known harms of the bushmeat trade and the detrimental life-long consequences that keeping chimpanzees as “pets” can have on their mental health.

  16. Design and Analysis of Landing Gear Mechanic Structure for the Mine Rescue Carrier Robot

    Directory of Open Access Journals (Sweden)

    Wei Juan

    2014-06-01

    Full Text Available The landing gear is used as a channel for the secondary detecting robot to leave and return the first carrier robot in the coal mine rescue robot system. The planar linkage mechanism, which is composed of offset rocker-slider mechanism and double-rocker mechanism, is designed according to the function and working principle of the landing gear. It could realize the 120° rotation of the flap with a motor driving the slider. The size calculation of the planar linkage mechanism is completed according to its workspace. The geometric modeling of the landing gear is made in the SolidWorks, and the basic Kinematic analysis is carried out by the simulation module of Motion. And the movement rule about angular displacement and angular velocity of the linkage mechanism could be obtained under given input condition, which could verify the system’s feasibility. It provides a theoretical basis for the structure design and engineering application of linkage mechanism and an applying basis for the coal mine rescue robot.

  17. The debtor-friendly fallacy in business rescue: Agency theory moderation and quasi relationships

    Directory of Open Access Journals (Sweden)

    Marius Pretorius

    2016-11-01

    Full Text Available Tension often arises when Chapter 6 business rescue practitioners (BRPs are appointed by directors to rescue their distressed businesses. Regulating by means of standard agency contracting becomes irrelevant in the resulting multiple relationships. Looking through the agency lens, using analytic autoethnography and compiling narratives, this paper explains the perceptions of what appear to be quasiagency relationships and obtains a better understanding of these. The findings suggest that the apparent principal-agent relationships suffer from asymmetries of goals, information access, informal power and diverging perceptions of moral hazard, transaction costs and adverse selection. As a solution, contracting has been shown to have limited value owing to outcome uncertainty and measurability. This is because the tasks of the BRP are non-programmable and term-dependent. The findings provide filing directors, shareholders, creditors, regulatory authorities and BRPs in this newly instituted regime, with enhanced understanding of how the relationships manifest in practice and overcome the non-contractibility of the newly formed relationships.

  18. La Serra d'Almos (Tarragona): an example of phenological data rescue and preservation in Catalonia

    Science.gov (United States)

    Busto, Montserrat; Cunillera, Jordi; de Yzaguirre, Xavi; Borrell, Josep

    2016-04-01

    The interruption of important phenological series and the progressive disappearance of phenological observations in Catalonia led the Meteorological Service of Catalonia (SMC) to design and impulse a new phenological network promoted by the Climate Change Unit of this Met Service. The "Fenocat" network was born in March 2013, and currently has around fifty observers distributed throughout Catalonia that observe plants, birds and butterflies. We are providing data from different plant phenophases to PEP725 database. Besides this new phenological network (Fenocat), one of the aims of SMC is to rescue and preserve historical data from different observation points in Catalonia. We show in this poster the example of rescue and preservation of phenological data from la Serra d'Almos (in Tivissa, near Tarragona, Catalonia, NE Iberian Peninsula), an observation series that began in 1973. After digitalization process and quality control tasks, we show preliminary results of this phenological series, and we compare them with those of similar European series. We show the evolution trends for different observed species, such as almond tree (Prunus dulcis), hazel (Corylus avellana), plum (Prunus domestica), olive tree (Olea europea), apple tree (Malus domestica) or vineyard (Vitis vinifera).

  19. XML and Better Web Searching.

    Science.gov (United States)

    Jackson, Joe; Gilstrap, Donald L.

    1999-01-01

    Addresses the implications of the new Web metalanguage XML for searching on the World Wide Web and considers the future of XML on the Web. Compared to HTML, XML is more concerned with structure of data than documents, and these data structures should prove conducive to precise, context rich searching. (Author/LRW)

  20. Spaced training rescues memory and ERK1/2 signaling in fragile X syndrome model mice.

    Science.gov (United States)

    Seese, Ronald R; Wang, Kathleen; Yao, Yue Qin; Lynch, Gary; Gall, Christine M

    2014-11-25

    Recent studies have shown that short, spaced trains of afferent stimulation produce much greater long-term potentiation (LTP) than that obtained with a single, prolonged stimulation episode. The present studies demonstrate that spaced training regimens, based on these LTP timing rules, facilitate learning in wild-type (WT) mice and can offset learning and synaptic signaling impairments in the fragile X mental retardation 1 (Fmr1) knockout (KO) model of fragile X syndrome. We determined that 5 min of continuous training supports object location memory (OLM) in WT but not Fmr1 KO mice. However, the same amount of training distributed across three short trials, spaced by one hour, produced robust long-term memory in the KOs. At least three training trials were needed to realize the benefit of spacing, and intertrial intervals shorter or longer than 60 min were ineffective. Multiple short training trials also rescued novel object recognition in Fmr1 KOs. The spacing effect was surprisingly potent: just 1 min of OLM training, distributed across three trials, supported robust memory in both genotypes. Spacing also rescued training-induced activation of synaptic ERK1/2 in dorsal hippocampus of Fmr1 KO mice. These results show that a spaced training regimen designed to maximize synaptic potentiation facilitates recognition memory in WT mice and can offset synaptic signaling and memory impairments in a model of congenital intellectual disability.

  1. Rhynchophylla total alkaloid rescues autophagy, decreases oxidative stress and improves endothelial vasodilation in spontaneous hypertensive rats.

    Science.gov (United States)

    Li, Chao; Jiang, Feng; Li, Yun-Lun; Jiang, Yue-Hua; Yang, Wen-Qing; Sheng, Jie; Xu, Wen-Juan; Zhu, Qing-Jun

    2018-03-01

    Autophagy plays an important role in alleviating oxidative stress and stabilizing atherosclerotic plaques. However, the potential role of autophagy in endothelial vasodilation function has rarely been studied. This study aimed to investigate whether rhynchophylla total alkaloid (RTA) has a positive role in enhancing autophagy through decreasing oxidative stress, and improving endothelial vasodilation. In oxidized low-density lipoprotein (ox-LDL)-treated human umbilical vein endothelial cells (HUVECs), RTA (200 mg/L) significantly suppressed ox-LDL-induced oxidative stress through rescuing autophagy, and decreased cell apoptosis. In spontaneous hypertensive rats (SHR), administration of RTA (50 mg·kg -1 ·d -1 , ip, for 6 weeks) improved endothelin-dependent vasodilation of thoracic aorta rings. Furthermore, RTA administration significantly increased the antioxidant capacity and alleviated oxidative stress through enhancing autophagy in SHR. In ox-LDL-treated HUVECs, we found that the promotion of autophagy by RTA resulted in activation of the AMP-activated protein kinase (AMPK) signaling pathway. Our results show that RTA treatment rescues the ox-LDL-induced autophagy impairment in HUVECs and improves endothelium-dependent vasodilation function in SHR.

  2. Multitasking Web Searching and Implications for Design.

    Science.gov (United States)

    Ozmutlu, Seda; Ozmutlu, H. C.; Spink, Amanda

    2003-01-01

    Findings from a study of users' multitasking searches on Web search engines include: multitasking searches are a noticeable user behavior; multitasking search sessions are longer than regular search sessions in terms of queries per session and duration; both Excite and AlltheWeb.com users search for about three topics per multitasking session and…

  3. Application of mathematical and computer methods in mine rescue. Primeneniye matematicheskikh metodov i EVM v gornospasatel'nom dele

    Energy Technology Data Exchange (ETDEWEB)

    1980-01-01

    The collection contains the following articles: ''Control automation in mine rescue''. Khudosovtzev N.M., Teper V.B., Shschukin O.F.; ''Selection of optimal control of fire-fighting equipment''. Kozlyuk A.I., Charkov V.P., Teper V.B.; ''Formal approach to describing the process of underground fire extinguishing''. Kozlyu, A.I., Teper V.B., Romanchuk A.L.,; ''Computer selection of rescue and accident prevention methods using situation control methods''. Starovoitov V.T., Tomarovshschenko V.D., Koifman Yu. L., Plepler R.,; ''Planning experiments for studying the foam generation process using a steam-gas mixture''. Karyagina N.V., Makarenko V.L., Zhukova N.E., Shkodskikh V.I.; ''Mathematical model of the temperature field of spontaneous coal combustion in a mined out area''. Chuntu G.I., Kalyusskii A.E., Lysenko E.P., Gusar G.A.; ''Mathematical model of the cooling process of rock by a gas flow''. Kleiner A.A., Semko V.N.; ''M/G/I system with selfcontained servicing''. Skripnik V.M.; ''Closed-circuit servicing with mobile one-channel devices''. Skripnik V.M.; ''Analysis of methods for describing accident situations when modelling mine rescue operations''. Shschukin O.F., Brusentzev G.K., Laktionov O.A.; ''PROLOG system and the solution to several artificial intelligence problems''. Belov V.N., Branovitzkii V.I., Getzko L.N., Kudryavtzeva S.P., Seraya V.V.; ''Representation of knowledge in interactive systems''. Branovitzkii V.I., Getzko L.N., Kudryavtzeva S.P., Sakhno A.A., Seraya V.V.; ''Programming the selection of fire extinguishing equipment for rapid control of underground fire fighting using a computer''. Teper V.B., Ibchenko I.B., Bychkov G.D.; ''Interactive method to assess the effectiveness of exogenous fire fighting methods''. Brusentzev G.K., Shschukin O.F., Laktionov O.A., Shulga O.N.; ''Practical instruction using the automatic 'mine rescuer' system''.

  4. Thought and Practice: Advanced Search

    African Journals Online (AJOL)

    Search tips: Search terms are case-insensitive; Common words are ignored; By default only articles containing all terms in the query are returned (i.e., AND is implied); Combine multiple words with OR to find articles containing either term; e.g., education OR research; Use parentheses to create more complex queries; e.g., ...

  5. Discovery and Innovation: Advanced Search

    African Journals Online (AJOL)

    Search tips: Search terms are case-insensitive; Common words are ignored; By default only articles containing all terms in the query are returned (i.e., AND is implied); Combine multiple words with OR to find articles containing either term; e.g., education OR research; Use parentheses to create more complex queries; e.g., ...

  6. Gender and Behaviour: Advanced Search

    African Journals Online (AJOL)

    Search tips: Search terms are case-insensitive; Common words are ignored; By default only articles containing all terms in the query are returned (i.e., AND is implied); Combine multiple words with OR to find articles containing either term; e.g., education OR research; Use parentheses to create more complex queries; e.g., ...

  7. Diversity, intent, and aggregated search

    NARCIS (Netherlands)

    de Rijke, M.

    2014-01-01

    Diversity, intent and aggregated search are three core retrieval concepts that receive significant attention. In search result diversification one typically considers the relevance of a document in light of other retrieved documents. The goal is to identify the probable "aspects" of an ambiguous

  8. Differential sensitivities of cellular XPA and PARP-1 to arsenite inhibition and zinc rescue.

    Science.gov (United States)

    Ding, Xiaofeng; Zhou, Xixi; Cooper, Karen L; Huestis, Juliana; Hudson, Laurie G; Liu, Ke Jian

    2017-09-15

    Arsenite directly binds to the zinc finger domains of the DNA repair protein poly (ADP ribose) polymerase (PARP)-1, and inhibits PARP-1 activity in the base excision repair (BER) pathway. PARP inhibition by arsenite enhances ultraviolet radiation (UVR)-induced DNA damage in keratinocytes, and the increase in DNA damage is reduced by zinc supplementation. However, little is known about the effects of arsenite and zinc on the zinc finger nucleotide excision repair (NER) protein xeroderma pigmentosum group A (XPA). In this study, we investigated the difference in response to arsenite exposure between XPA and PARP-1, and the differential effectiveness of zinc supplementation in restoring protein DNA binding and DNA damage repair. Arsenite targeted both XPA and PARP-1 in human keratinocytes, resulting in zinc loss from each protein and a pronounced decrease in XPA and PARP-1 binding to chromatin as demonstrated by Chip-on-Western assays. Zinc effectively restored DNA binding of PARP-1 and XPA to chromatin when zinc concentrations were equal to those of arsenite. In contrast, zinc was more effective in rescuing arsenite-augmented direct UVR-induced DNA damage than oxidative DNA damage. Taken together, our findings indicate that arsenite interferes with PARP-1 and XPA binding to chromatin, and that zinc supplementation fully restores DNA binding activity to both proteins in the cellular context. Interestingly, rescue of arsenite-inhibited DNA damage repair by supplemental zinc was more sensitive for DNA damage repaired by the XPA-associated NER pathway than for the PARP-1-dependent BER pathway. This study expands our understanding of arsenite's role in DNA repair inhibition and co-carcinogenesis. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. A Prefiltered Cuckoo Search Algorithm with Geometric Operators for Solving Sudoku Problems

    Directory of Open Access Journals (Sweden)

    Ricardo Soto

    2014-01-01

    Full Text Available The Sudoku is a famous logic-placement game, originally popularized in Japan and today widely employed as pastime and as testbed for search algorithms. The classic Sudoku consists in filling a 9×9 grid, divided into nine 3×3 regions, so that each column, row, and region contains different digits from 1 to 9. This game is known to be NP-complete, with existing various complete and incomplete search algorithms able to solve different instances of it. In this paper, we present a new cuckoo search algorithm for solving Sudoku puzzles combining prefiltering phases and geometric operations. The geometric operators allow one to correctly move toward promising regions of the combinatorial space, while the prefiltering phases are able to previously delete from domains the values that do not conduct to any feasible solution. This integration leads to a more efficient domain filtering and as a consequence to a faster solving process. We illustrate encouraging experimental results where our approach noticeably competes with the best approximate methods reported in the literature.

  10. VEGF and IHH rescue definitive hematopoiesis in Gata-4 and Gata-6-deficient murine embryoid bodies.

    Science.gov (United States)

    Pierre, Monique; Yoshimoto, Momoko; Huang, Lan; Richardson, Matthew; Yoder, Mervin C

    2009-09-01

    Murine embryonic stem cells can be differentiated into embryoid bodies (EBs), which serve as an in vitro model recapitulating many aspects of embryonic yolk sac hematopoiesis. Differentiation of embryonic stem cells deficient in either Gata-4 or Gata-6 results in EBs with disrupted visceral endoderm (VE). While lack of VE has detrimental effects on hematopoiesis in vivo, it is unclear whether lack of VE affects hematopoiesis in EBs. Therefore, we compared Gata-4 null (G4N) and Gata-6 null (G6N) EBs with wild-type EBs to assess their ability to commit to hematopoietic cells. EB VE formation was examined using cell-sorting techniques and analysis visceral endoderm gene expression. Hematopoietic progenitor potential of EBs cultured under various conditions was assessed using colony-forming assays. Definitive erythroid, granulocyte-macrophage, and mixed colonies were significantly reduced in G4N and G6N EBs compared to wild-type EBs. Vascular endothelial growth factor (VEGF) expression and secretion were also reduced in both G4N and G6N EBs, consistent with VE serving as a site of VEGF production. Addition of exogenous VEGF(165), to EB cultures completely rescued definitive colony-forming cells in G4N and G6N EBs. This rescue response could be blocked by addition of soluble Flk-1 Fc to EB cultures. Similarly, addition of exogenous Indian hedgehog to EB cultures also recovers the diminishment in definitive hematopoiesis in a reversible manner. These results suggest that the absence of VE in G4N and G6N EBs does not prevent emergence of definitive progenitors from EBs. However, the decreased level of VEGF and Indian hedgehog production in VE devoid G4N and G6N EBs attenuates definitive hematopoietic progenitor cell expansion.

  11. 46 CFR 108.575 - Survival craft and rescue boat equipment.

    Science.gov (United States)

    2010-10-01

    ... Fishing kit 1 1 12 Flashlight 1 1 1 1 1 1 13 Hatchet 2 2 14 Heaving line 2 1 2 2 1 2 15 Instruction card 1... rigid/inflated rescue boats. 4 A hatchet counts toward this requirement in rigid rescue boats. 5 Oars...

  12. Search Improvement Process-Chaotic Optimization-Particle Swarm Optimization-Elite Retention Strategy and Improved Combined Cooling-Heating-Power Strategy Based Two-Time Scale Multi-Objective Optimization Model for Stand-Alone Microgrid Operation

    Directory of Open Access Journals (Sweden)

    Fei Wang

    2017-11-01

    Full Text Available The optimal dispatching model for a stand-alone microgrid (MG is of great importance to its operation reliability and economy. This paper aims at addressing the difficulties in improving the operational economy and maintaining the power balance under uncertain load demand and renewable generation, which could be even worse in such abnormal conditions as storms or abnormally low or high temperatures. A new two-time scale multi-objective optimization model, including day-ahead cursory scheduling and real-time scheduling for finer adjustments, is proposed to optimize the operational cost, load shedding compensation and environmental benefit of stand-alone MG through controllable load (CL and multi-distributed generations (DGs. The main novelty of the proposed model is that the synergetic response of CL and energy storage system (ESS in real-time scheduling offset the operation uncertainty quickly. And the improved dispatch strategy for combined cooling-heating-power (CCHP enhanced the system economy while the comfort is guaranteed. An improved algorithm, Search Improvement Process-Chaotic Optimization-Particle Swarm Optimization-Elite Retention Strategy (SIP-CO-PSO-ERS algorithm with strong searching capability and fast convergence speed, was presented to deal with the problem brought by the increased errors between actual renewable generation and load and prior predictions. Four typical scenarios are designed according to the combinations of day types (work day or weekend and weather categories (sunny or rainy to verify the performance of the presented dispatch strategy. The simulation results show that the proposed two-time scale model and SIP-CO-PSO-ERS algorithm exhibit better performance in adaptability, convergence speed and search ability than conventional methods for the stand-alone MG’s operation.

  13. Identification of human-induced initiating events in the low power and shutdown operation using the commission error search and assessment method

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yong Chan; Kim, Jong Hyun [KEPCO International Nuclear Graduate School (KINGS), Ulsan (Korea, Republic of)

    2015-03-15

    Human-induced initiating events, also called Category B actions in human reliability analysis, are operator actions that may lead directly to initiating events. Most conventional probabilistic safety analyses typically assume that the frequency of initiating events also includes the probability of human-induced initiating events. However, some regulatory documents require Category B actions to be specifically analyzed and quantified in probabilistic safety analysis. An explicit modeling of Category B actions could also potentially lead to important insights into human performance in terms of safety. However, there is no standard procedure to identify Category B actions. This paper describes a systematic procedure to identify Category B actions for low power and shutdown conditions. The procedure includes several steps to determine operator actions that may lead to initiating events in the low power and shutdown stages. These steps are the selection of initiating events, the selection of systems or components, the screening of unlikely operating actions, and the quantification of initiating events. The procedure also provides the detailed instruction for each step, such as operator's action, information required, screening rules, and the outputs. Finally, the applicability of the suggested approach is also investigated by application to a plant example.

  14. 49 CFR 238.114 - Rescue access windows.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Rescue access windows. 238.114 Section 238.114... § 238.114 Rescue access windows. (a) Number and location. Except as provided in paragraph (a)(1)(ii) of... rescue access windows. At least one rescue access window shall be located in each side of the car...

  15. Searching and Archiving : Exploring Online Search Behaviors of Researchers

    NARCIS (Netherlands)

    Vyas, Dhaval; de Groot, S.; van der Veer, Gerrit C.; Dainoff, Marvin J.

    2007-01-01

    Searching for relevant peer-reviewed material is an integral part of corporate and academic researchers. Researchers collect huge amount of information over the years and sometimes struggle organizing it. Based on a study with 30 academic researchers, we explore, in combination, different searching

  16. Exploring the Interplay between Rescue Drugs, Data Imputation, and Study Outcomes: Conceptual Review and Qualitative Analysis of an Acute Pain Data Set.

    Science.gov (United States)

    Singla, Neil K; Meske, Diana S; Desjardins, Paul J

    2017-12-01

    In placebo-controlled acute surgical pain studies, provisions must be made for study subjects to receive adequate analgesic therapy. As such, most protocols allow study subjects to receive a pre-specified regimen of open-label analgesic drugs (rescue drugs) as needed. The selection of an appropriate rescue regimen is a critical experimental design choice. We hypothesized that a rescue regimen that is too liberal could lead to all study arms receiving similar levels of pain relief (thereby confounding experimental results), while a regimen that is too stringent could lead to a high subject dropout rate (giving rise to a preponderance of missing data). Despite the importance of rescue regimen as a study design feature, there exist no published review articles or meta-analysis focusing on the impact of rescue therapy on experimental outcomes. Therefore, when selecting a rescue regimen, researchers must rely on clinical factors (what analgesics do patients usually receive in similar surgical scenarios) and/or anecdotal evidence. In the following article, we attempt to bridge this gap by reviewing and discussing the experimental impacts of rescue therapy on a common acute surgical pain population: first metatarsal bunionectomy. The function of this analysis is to (1) create a framework for discussion and future exploration of rescue as a methodological study design feature, (2) discuss the interplay between data imputation techniques and rescue drugs, and (3) inform the readership regarding the impact of data imputation techniques on the validity of study conclusions. Our findings indicate that liberal rescue may degrade assay sensitivity, while stringent rescue may lead to unacceptably high dropout rates.

  17. 33 CFR 149.304 - What type and how many survival craft and rescue boats must a manned deepwater port have?

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false What type and how many survival craft and rescue boats must a manned deepwater port have? 149.304 Section 149.304 Navigation and... What type and how many survival craft and rescue boats must a manned deepwater port have? (a) Except as...

  18. A critical comparison between how the rights of employees are affected by winding-up and business rescue proceedings

    OpenAIRE

    2015-01-01

    LL.M. (Commercial law) This dissertation seeks to explore the fundamental differences between the rights of employees in terms of windiqg-up procedures and that of business rescue proceedings. I will be specifically looking at each procedure, winding-up and business rescue proceedings, and the effect that each of these procedures have on the rights of employees. In terms of the analysis of the procedures, I will be looking at the history of both insolvency law and labour law, as well as a ...

  19. Multipass Target Search in Natural Environments.

    Science.gov (United States)

    Kuhlman, Michael J; Otte, Michael W; Sofge, Donald; Gupta, Satyandra K

    2017-11-02

    Consider a disaster scenario where search and rescue workers must search difficult to access buildings during an earthquake or flood. Often, finding survivors a few hours sooner results in a dramatic increase in saved lives, suggesting the use of drones for expedient rescue operations. Entropy can be used to quantify the generation and resolution of uncertainty. When searching for targets, maximizing mutual information of future sensor observations will minimize expected target location uncertainty by minimizing the entropy of the future estimate. Motion planning for multi-target autonomous search requires planning over an area with an imperfect sensor and may require multiple passes, which is hindered by the submodularity property of mutual information. Further, mission duration constraints must be handled accordingly, requiring consideration of the vehicle's dynamics to generate feasible trajectories and must plan trajectories spanning the entire mission duration, something which most information gathering algorithms are incapable of doing. If unanticipated changes occur in an uncertain environment, new plans must be generated quickly. In addition, planning multipass trajectories requires evaluating path dependent rewards, requiring planning in the space of all previously selected actions, compounding the problem. We present an anytime algorithm for autonomous multipass target search in natural environments. The algorithm is capable of generating long duration dynamically feasible multipass coverage plans that maximize mutual information using a variety of techniques such as ϵ -admissible heuristics to speed up the search. To the authors' knowledge this is the first attempt at efficiently solving multipass target search problems of such long duration. The proposed algorithm is based on best first branch and bound and is benchmarked against state of the art algorithms adapted to the problem in natural Simplex environments, gathering the most information in the

  20. Intravenous dextrose administration reduces postoperative antiemetic rescue treatment requirements and postanesthesia care unit length of stay.

    Science.gov (United States)

    Dabu-Bondoc, Susan; Vadivelu, Nalini; Shimono, Chantelle; English, Annette; Kosarussavadi, Boonsri; Dai, Feng; Shelley, Kirk; Feinleib, Jessica

    2013-09-01

    Postoperative nausea and vomiting (PONV) remains the most common postoperative complication, and causes decreased patient satisfaction, prolonged postoperative hospital stays, and unanticipated admission. There are limited data that indicate that dextrose may reduce nausea and vomiting. In this trial, we attempted to determine whether the rate of PONV can be decreased by postoperative administration of IV dextrose bolus. To test the effect of postoperative dextrose administration on PONV rates, we conducted a double-blind, randomized, placebo-controlled trial. We enrolled 62 nondiabetic, ASA class I or II nonsmoking outpatients scheduled for gynecologic laparoscopic and hysteroscopic procedures. Patients were randomized into 2 groups: the treatment group received dextrose 5% in Ringer lactate solution, and the control (placebo) group received Ringer lactate solution given immediately after surgery. All patients underwent a standardized general anesthesia and received 1 dose of antiemetic a half hour before emergence from anesthesia. PONV scores, antiemetic rescue medications, narcotic consumption, and discharge time were recorded in the postanesthesia care unit (PACU) in half-hour intervals. The 2 groups were similar with regard to age, weight, anxiety scores, prior PONV, non per os status, presurgical glucose, anesthetic duration, intraoperative narcotic use, and total weight-based fluid volume received. Postoperative nausea scores were not significantly different in the dextrose group compared with the control group (P > 0.05) after Bonferroni correction for repeated measurements over time. However, patients who received dextrose 5% in Ringer lactate solution consumed less rescue antiemetic medications (ratio mean difference, 0.56; 95% confidence interval, 0.39-0.82; P = 0.02), and had a shorter length of stay in the PACU (ratio mean difference, 0.80; 95% confidence interval, 0.66-0.97; P = 0.03) compared with patients in the control group. In this trial

  1. LITERATURE SEARCH FOR METHODS FOR HAZARD ANALYSES OF AIR CARRIER OPERATIONS.

    Energy Technology Data Exchange (ETDEWEB)

    MARTINEZ - GURIDI,G.; SAMANTA,P.

    2002-07-01

    Representatives of the Federal Aviation Administration (FAA) and several air carriers under Title 14 of the Code of Federal Regulations (CFR) Part 121 developed a system-engineering model of the functions of air-carrier operations. Their analyses form the foundation or basic architecture upon which other task areas are based: hazard analyses, performance measures, and risk indicator design. To carry out these other tasks, models may need to be developed using the basic architecture of the Air Carrier Operations System Model (ACOSM). Since ACOSM encompasses various areas of air-carrier operations and can be used to address different task areas with differing but interrelated objectives, the modeling needs are broad. A literature search was conducted to identify and analyze the existing models that may be applicable for pursuing the task areas in ACOSM. The intent of the literature search was not necessarily to identify a specific model that can be directly used, but rather to identify relevant ones that have similarities with the processes and activities defined within ACOSM. Such models may provide useful inputs and insights in structuring ACOSM models. ACOSM simulates processes and activities in air-carrier operation, but, in a general framework, it has similarities with other industries where attention also has been paid to hazard analyses, emphasizing risk management, and in designing risk indicators. To assure that efforts in other industries are adequately considered, the literature search includes publications from other industries, e.g., chemical, nuclear, and process industries. This report discusses the literature search, the relevant methods identified and provides a preliminary assessment of their use in developing the models needed for the ACOSM task areas. A detailed assessment of the models has not been made. Defining those applicable for ACOSM will need further analyses of both the models and tools identified. The report is organized in four chapters

  2. An adaptive immune optimization algorithm with dynamic lattice searching operation for fast optimization of atomic clusters

    International Nuclear Information System (INIS)

    Wu, Xia; Wu, Genhua

    2014-01-01

    Highlights: • A high efficient method for optimization of atomic clusters is developed. • Its performance is studied by optimizing Lennard-Jones clusters and Ag clusters. • The method is proved to be quite efficient. • A new Ag 61 cluster with stacking-fault face-centered cubic motif is found. - Abstract: Geometrical optimization of atomic clusters is performed by a development of adaptive immune optimization algorithm (AIOA) with dynamic lattice searching (DLS) operation (AIOA-DLS method). By a cycle of construction and searching of the dynamic lattice (DL), DLS algorithm rapidly makes the clusters more regular and greatly reduces the potential energy. DLS can thus be used as an operation acting on the new individuals after mutation operation in AIOA to improve the performance of the AIOA. The AIOA-DLS method combines the merit of evolutionary algorithm and idea of dynamic lattice. The performance of the proposed method is investigated in the optimization of Lennard-Jones clusters within 250 atoms and silver clusters described by many-body Gupta potential within 150 atoms. Results reported in the literature are reproduced, and the motif of Ag 61 cluster is found to be stacking-fault face-centered cubic, whose energy is lower than that of previously obtained icosahedron

  3. Levy flights and random searches

    Energy Technology Data Exchange (ETDEWEB)

    Raposo, E P [Laboratorio de Fisica Teorica e Computacional, Departamento de Fisica, Universidade Federal de Pernambuco, Recife-PE, 50670-901 (Brazil); Buldyrev, S V [Department of Physics, Yeshiva University, New York, 10033 (United States); Da Luz, M G E [Departamento de Fisica, Universidade Federal do Parana, Curitiba-PR, 81531-990 (Brazil); Viswanathan, G M [Instituto de Fisica, Universidade Federal de Alagoas, Maceio-AL, 57072-970 (Brazil); Stanley, H E [Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215 (United States)

    2009-10-30

    In this work we discuss some recent contributions to the random search problem. Our analysis includes superdiffusive Levy processes and correlated random walks in several regimes of target site density, mobility and revisitability. We present results in the context of mean-field-like and closed-form average calculations, as well as numerical simulations. We then consider random searches performed in regular lattices and lattices with defects, and we discuss a necessary criterion for distinguishing true superdiffusion from correlated random walk processes. We invoke energy considerations in relation to critical survival states on the edge of extinction, and we analyze the emergence of Levy behavior in deterministic search walks. Finally, we comment on the random search problem in the context of biological foraging.

  4. Housing Search and Consumption Adjustment,

    Science.gov (United States)

    1980-04-01

    bility have appeared in the literature (Speare et al., 1975; Hanushek and Quigley, 1978; Brummell, 1979). Although differing on specifics, these...divide into two types: formal models of the decision to move (Speare et al., 1975; Hanushek and Quigley, 1978) that recognize housing search as a trans...effort expended in searching for a new unit (Abt, 1978; Hanushek and Quigley, 1978; Cronin, 1978). Geographers refer to residential stress and resistance

  5. Construction and Rescue of a Molecular Clone of Deformed Wing Virus (DWV.

    Directory of Open Access Journals (Sweden)

    Benjamin Lamp

    Full Text Available European honey bees are highly important in crop pollination, increasing the value of global agricultural production by billions of dollars. Current knowledge about virulence and pathogenicity of Deformed wing virus (DWV, a major factor in honey bee colony mortality, is limited. With this study, we close the gap between field research and laboratory investigations by establishing a complete in vitro model for DWV pathogenesis. Infectious DWV was rescued from a molecular clone of a DWV-A genome that induces DWV symptoms such as crippled wings and discoloration. The expression of DWV proteins, production of infectious virus progeny, and DWV host cell tropism could be confirmed using newly generated anti-DWV monoclonal antibodies. The recombinant RNA fulfills Koch's postulates circumventing the need of virus isolation and propagation of pure virus cultures. In conclusion, we describe the development and application of a reverse genetics system for the study of DWV pathogenesis.

  6. Hybridized Symbiotic Organism Search Algorithm for the Optimal Operation of Directional Overcurrent Relays

    Directory of Open Access Journals (Sweden)

    Muhammad Sulaiman

    2018-01-01

    Full Text Available This paper presents the solution of directional overcurrent relay (DOCR problems using Simulated Annealing based Symbiotic Organism Search (SASOS. The objective function of the problem is to minimize the sum of the operating times of all primary relays. The DOCR problem is nonlinear and highly constrained with two types of decision variables, namely, the time dial settings (TDS and plug setting (PS. In this paper, three models of the problem are considered, the IEEE 3-bus, 4-bus, and 6-bus, respectively. We have applied SASOS to solve the problem and the obtained results are compared with other algorithms available in the literature.

  7. Deletion of PTH rescues skeletal abnormalities and high osteopontin levels in Klotho-/- mice.

    Directory of Open Access Journals (Sweden)

    Quan Yuan

    Full Text Available Maintenance of normal mineral ion homeostasis is crucial for many biological activities, including proper mineralization of the skeleton. Parathyroid hormone (PTH, Klotho, and FGF23 have been shown to act as key regulators of serum calcium and phosphate homeostasis through a complex feedback mechanism. The phenotypes of Fgf23(-/- and Klotho(-/- (Kl(-/- mice are very similar and include hypercalcemia, hyperphosphatemia, hypervitaminosis D, suppressed PTH levels, and severe osteomalacia/osteoidosis. We recently reported that complete ablation of PTH from Fgf23(-/- mice ameliorated the phenotype in Fgf23(-/-/PTH(-/- mice by suppressing serum vitamin D and calcium levels. The severe osteomalacia in Fgf23(-/- mice, however, persisted, suggesting that a different mechanism is responsible for this mineralization defect. In the current study, we demonstrate that deletion of PTH from Kl(-/- (Kl(-/-/PTH(-/- or DKO mice corrects the abnormal skeletal phenotype. Bone turnover markers are restored to wild-type levels; and, more importantly, the skeletal mineralization defect is completely rescued in Kl(-/-/PTH(-/- mice. Interestingly, the correction of the osteomalacia is accompanied by a reduction in the high levels of osteopontin (Opn in bone and serum. Such a reduction in Opn levels could not be observed in Fgf23(-/-/PTH(-/- mice, and these mice showed sustained osteomalacia. This significant in vivo finding is corroborated by in vitro studies using calvarial osteoblast cultures that show normalized Opn expression and rescued mineralization in Kl(-/-/PTH(-/- mice. Moreover, continuous PTH infusion of Kl(-/- mice significantly increased Opn levels and osteoid volume, and decreased trabecular bone volume. In summary, our results demonstrate for the first time that PTH directly impacts the mineralization disorders and skeletal deformities of Kl(-/-, but not of Fgf23(-/- mice, possibly by regulating Opn expression. These are significant new perceptions into

  8. Rescue Implantation of Expandable Cages for Severe Osteolysis and Cage Dislocation in the Lumbosacral Junction.

    Science.gov (United States)

    Schatlo, Bawarjan; Rohde, Veit; Solomiichuk, Volodymyr; von Eckardstein, Kajetan; Behm, Timo

    2017-11-01

    Osteolysis and implant loosening are commonly encountered problems after spinal instrumentation. In a patient who had previously undergone a posterior lumbar interbody fusion procedure, fusion did not occur, and a secondary cage dislocation led to an impingement of the L5 nerve root with severe radiculopathy. Revision surgery was performed. Intraoperatively, osteolysis was found to be so severe that conventional cages did not fill the void to allow for sufficient anterior column support. We used expandable transforaminal lumbar interbody fusion cages and implanted them bilaterally to replace the dislodged posterior lumbar interbody fusion cages. Clinical follow-up was uneventful. Imaging performed at 1 year showed satisfactory cage position and fusion. We propose the use of cages with the ability of ventral distraction in similar rescue interventions with cage dislocation and bone resorption. This may prevent a second surgery via a ventral approach. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Advanced airway management in hoist and longline operations in mountain HEMS - considerations in austere environments: a narrative review This review is endorsed by the International Commission for Mountain Emergency Medicine (ICAR MEDCOM).

    Science.gov (United States)

    Pietsch, Urs; Knapp, Jürgen; Kreuzer, Oliver; Ney, Ludwig; Strapazzon, Giacomo; Lischke, Volker; Albrecht, Roland; Phillips, Patrick; Rauch, Simon

    2018-04-03

    Providing sufficient oxygenation and ventilation is of paramount importance for the survival of emergency patients. Therefore, advanced airway management is one of the core tasks for every rescue team. Endotracheal intubation is the gold standard to secure the airway in the prehospital setting. This review aims to highlight special considerations for advanced airway management preceding human external cargo (HEC) evacuations. We systematically searched MEDLINE, EMBASE, and PubMed in August 2017 for articles on airway management and ventilation in patients before hoist or longline operation in HEMS. Relevant reference lists were hand-searched. Three articles with regard to advanced airway management and five articles concerning the epidemiology of advanced airway management in hoist or longline rescue missions were included. We found one case report regarding ventilation during hoist operations. The exact incidence of advanced airway management before evacuation of a patient by HEC is unknown but seems to be very low (< 5%). There are several hazards which can impede mechanical ventilation of patients during HEC extractions: loss of equipment, hyperventilation, inability to ventilate and consequent hypoxia, as well as inadequacy of monitoring. Advanced airway management prior to HEC operation is rarely performed. If intubation before helicopter hoist operations (HHO) and human cargo sling (HCS) extraction is considered by the rescue team, a risk/benefit analysis should be performed and a clear standard operating procedure (SOP) should be defined. Continuous and rigorous training including the whole crew is required. An international registry on airway management during HEC extraction would be desirable.

  10. Isolation, Genome Phylogenetic Analysis and In vitro Rescue of a Newly Emerging Porcine Circovirus Type 2

    Directory of Open Access Journals (Sweden)

    Weijuan Zhu and Xiaofeng Ren*

    2012-05-01

    Full Text Available Porcine circovirus type 2 (PCV2 is the major causative agent of post-weaning multisystemic wasting syndrome (PMWS. Infection by PCV2 may cause heavy losses in pig industry. In this study, we report the isolation of a newly emerging PCV2 from northeastern China. The complete genome of the PCV2 isolate named PCV2-LJR contains 1766 nucleotides and was compared with reference sequences published in GenBank followed by topology analysis of the resulting phylogenetic tree. The data indicated that the prevalent PCV2 isolates in the northeastern China had close relationship, although various genotypes of PCV2 existed. In addition, by gene recombination and transfection techniques, the PCV2 infectious clone was achieved and was able to rescue virus in vitro determined by indirect immunofluorescence assay and PCR. The obtained biological materials may be used for biological characterization of PCV2.

  11. Rescue workers and trauma: Assessing interaction among risk factors after a firework factory explosion.

    Science.gov (United States)

    Romano, Eugenia; Elklit, Ask

    This study investigates which factors had the biggest impact on developing distress in rescue workers who were involved in a firework factory explosion. Four hundred sixty-five rescuers were assessed using items investigating demographic factors, organizational variables, social support, personality variables, and distress symptoms. Correlation and regression analyses were performed. Our final model provided 70 percent of the predictive model for post-traumatic stress disorder (PTSD) severity. Waiting time, lack of rest, problems at work, and perceived level of danger seemed to have the highest impact on protective factors. In addition to perceived life danger and personality, small organizational factors seem to play an important role in the prediction of PTSD. The importance of such factors needs further investigation in future research, contributing to a better organization in the field of disaster management.

  12. Promotion and Rescue of Intracellular Brucella neotomae Replication during Coinfection with Legionella pneumophila.

    Science.gov (United States)

    Kang, Yoon-Suk; Kirby, James E

    2017-05-01

    We established a new Brucella neotomae in vitro model system for study of type IV secretion system-dependent (T4SS) pathogenesis in the Brucella genus. Importantly, B. neotomae is a rodent pathogen, and unlike B. abortus , B. melitensis , and B. suis , B. neotomae has not been observed to infect humans. It therefore can be handled more facilely using biosafety level 2 practices. More particularly, using a series of novel fluorescent protein and lux operon reporter systems to differentially label pathogens and track intracellular replication, we confirmed T4SS-dependent intracellular growth of B. neotomae in macrophage cell lines. Furthermore, B. neotomae exhibited early endosomal (LAMP-1) and late endoplasmic reticulum (calreticulin)-associated phagosome maturation. These findings recapitulate prior observations for human-pathogenic Brucella spp. In addition, during coinfection experiments with Legionella pneumophila , we found that defective intracellular replication of a B. neotomae T4SS virB4 mutant was rescued and baseline levels of intracellular replication of wild-type B. neotomae were significantly stimulated by coinfection with wild-type but not T4SS mutant L. pneumophila Using confocal microscopy, it was determined that intracellular colocalization of B. neotomae and L. pneumophila was required for rescue and that colocalization came at a cost to L. pneumophila fitness. These findings were not completely expected based on known temporal and qualitative differences in the intracellular life cycles of these two pathogens. Taken together, we have developed a new system for studying in vitro Brucella pathogenesis and found a remarkable T4SS-dependent interplay between Brucella and Legionella during macrophage coinfection. Copyright © 2017 American Society for Microbiology.

  13. Assessment of exposure to carbon monoxide group of firefighters from fire fighting and rescue units

    Directory of Open Access Journals (Sweden)

    Jadwiga Lembas-Bogaczyk

    2011-03-01

    Full Text Available Firemen threat during fire burning of chemical substances indicated presence of carbon monoxide (CO in all cases. Carbon monoxide causes death of fire. Inhaled through respiratory system, links with hemoglobin, thus blocking transport and distribution of oxygen in the body. This leads to tissue anoxia, which is a direct threat to firefighters’ life. The purpose of this study was to assess the exposure to carbon monoxide of participating firefighters extinguishing fire. Estimation of carbon monoxide quantity absorbed by firefighters was isolated in a group of 40 firefighters from Fire Extinguishing and Rescue Unit of State Fire in Nysa. The study was conducted by measuring carbon monoxide in exhaled air. For measurement of carbon monoxide concentration in exhaled air Micro CO meter was used. Results were demonstrated separately for nonsmokers (n425 and smokers (n415. Mean COHb[%] levels in nonsmokers, measured prior the rescue action was 0,3950,3% and increased statistically significant after the action to 0,6150,34%, while in the group smokers, this level was 2,1750,64% before the action and increased insignificantly after the action to 2,3350,63%. The average COHb level in the same groups before and after exercise, was respectively: for nonsmokers prior to exercise was 0,4850,28% and after exercise decreased statistically significant to 0,3050,27%. In the group of smokers before exercise was 2,2350,61% and decreased statistically significant up to 1,5450,71%. It was no difference between the group of age and time of employment.

  14. [Impact of sperm DNA and acrosome integrity and acrosome reaction rate on outcomes of rescue intracytoplasmic sperm injection].

    Science.gov (United States)

    He, Yongzhi; Li, Dawen; Cheng, Junping; Huo, Zhongchao; Huang, Hongyi; Xiao, Xin

    2016-01-01

    Objective To explore the effects of sperm DNA integrity rate, acrosome integrity rate and acrosome reaction rate on the outcomes of rescue intracytoplasmic sperm injection (ICSI). This retrospective analysis was conducted among 97 infertile couples receiving rescue ICSI due to failure of in vitro fertilization procedures in our Reproductive Medicine Center. Of these 97 women, 41 had clinical pregnancy and 56 did not, and the effects of sperm DNA integrity rate (estimated by DNA fragmentation index, DFI), acrosome integrity rate and acrosome reaction rate on rescue ICSI outcomes were analyzed. No significant difference was found in paternal age, testosterone value, testicular volume, FSH, female patient' age or the number of eggs retrieved between the two groups (P>0.05), but the infertility years was significantly shorter in the pregnancy group than in the non-pregnancy group (Prate and cleavage rate were similar between the two groups (P>0.05), but the good embryo rate was significantly higher in the pregnancy group (Preaction rate did not differ significantly between the two groups (P>0.05), but the acrosome integrity rate was significantly higher in the pregnancy group (Prate, acrosome integrity or acrosome reaction rate were not correlated with the fertilization rate, cleavage rate or good embryo rate (P>0.05). The pregnancy rate, twin and single fetus rates were 42.3%, 10.3% and 32.0% in this cohort after recue ICSI, respectively. Rescue ICSI is an effective treatment after failed in vitro fertilization procedure, and sperm acrosome integrity rate is associated with the outcome of rescue ICSI.

  15. Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency

    Directory of Open Access Journals (Sweden)

    Yan M

    2015-10-01

    Full Text Available Meng Yan,1 Kaiping Zhang,1 Yanhui Shi,1 Lifang Feng,1 Lin Lv,1 Baoxin Li1,2 1Department of Pharmacology, Harbin Medical University, 2State-Province Key Laboratory of Biopharmaceutical Engineering, Harbin, Heilongjiang, People’s Republic of China Abstract: Berberine (BBR, an isoquinoline alkaloid mainly isolated from plants of Berberidaceae family, is extensively used to treat gastrointestinal infections in clinics. It has been reported that BBR can block human ether-a-go-go-related gene (hERG potassium channel and inhibit its membrane expression. The hERG channel plays crucial role in cardiac repolarization and is the target of diverse proarrhythmic drugs. Dysfunction of hERG channel can cause long QT syndrome. However, the regulatory mechanisms of BBR effects on hERG at cell membrane level remain unknown. This study was designed to investigate in detail how BBR decreased hERG expression on cell surface and further explore its pharmacological rescue strategies. In this study, BBR decreases caveolin-1 expression in a concentration-dependent manner in human embryonic kidney 293 (HEK293 cells stably expressing hERG channel. Knocking down the basal expression of caveolin-1 alleviates BBR-induced hERG reduction. In addition, we found that aromatic tyrosine (Tyr652 and phenylalanine (Phe656 in S6 domain mediate the long-term effect of BBR on hERG by using mutation techniques. Considering both our previous and present work, we propose that BBR reduces hERG membrane stability with multiple mechanisms. Furthermore, we found that fexofenadine and resveratrol shorten action potential duration prolongated by BBR, thus having the potential effects of alleviating the cardiotoxicity of BBR. Keywords: berberine, hERG, cavoline-1, cardiotoxicity, LQTS, pharmacological rescue

  16. Operator programs and operator processes

    NARCIS (Netherlands)

    Bergstra, J.A.; Walters, P.

    2003-01-01

    We define a notion of program which is not a computer program but an operator program: a detailed description of actions performed and decisions taken by a human operator (computer user) performing a task to achieve a goal in a simple setting consisting of that user, one or more computers and a

  17. The rule of rescue.

    Science.gov (United States)

    McKie, John; Richardson, Jeff

    2003-06-01

    Jonsen coined the term "Rule of Rescue"(RR) to describe the imperative people feel to rescue identifiable individuals facing avoidable death. In this paper we attempt to draw a more detailed picture of the RR, identifying its conflict with cost-effectiveness analysis, the preference it entails for identifiable over statistical lives, the shock-horror response it elicits, the preference it entails for lifesaving over non-lifesaving measures, its extension to non-life-threatening conditions, and whether it is motivated by duty or sympathy. We also consider the measurement problems it raises, and argue that quantifying the RR would probably require a two-stage procedure. In the first stage the size of the individual utility gain from a health intervention would be assessed using a technique such as the Standard Gamble or the Time Trade-Off, and in the second the social benefits arising from the RR would be quantified employing the Person Trade-Off. We also consider the normative status of the RR. We argue that it can be defended from a utilitarian point of view, on the ground that rescues increase well-being by reinforcing people's belief that they live in a community that places great value upon life. However, utilitarianism has long been criticised for failing to take sufficient account of fairness, and the case is no different here: fairness requires that we do not discriminate between individuals on morally irrelevant grounds, whereas being "identifiable" does not seem to be a morally relevant ground for discrimination.

  18. Matrix vaccination guidelines : 2015 ABCD recommendations for indoor/outdoor cats, rescue shelter cats and breeding catteries

    NARCIS (Netherlands)

    Hosie, Margaret J; Addie, Diane D; Boucraut-Baralon, Corine; Egberink, Herman; Frymus, Tadeusz; Gruffydd-Jones, Tim; Hartmann, Katrin; Horzinek, Marian C; Lloret, Albert; Lutz, Hans; Marsilio, Fulvio; Pennisi, Maria Grazia; Radford, Alan D; Thiry, Etienne; Truyen, Uwe; Möstl, Karin

    OVERVIEW: In 2013, the ABCD published 'Matrix vaccination guidelines: ABCD recommendations for indoor/outdoor cats, rescue shelter cats and breeding catteries' in a Special Issue of the Journal of Feline Medicine and Surgery (Volume 15, Issue 7, pages 540-544). The ABCD's vaccination recommendations

  19. Two-tier Haddon matrix approach to fault analysis of accidents and cybernetic search for relationship to effect operational control: a case study at a large construction site.

    Science.gov (United States)

    Mazumdar, Atmadeep; Sen, Krishna Nirmalya; Lahiri, Balendra Nath

    2007-01-01

    The Haddon matrix is a potential tool for recognizing hazards in any operating engineering system. This paper presents a case study of operational hazards at a large construction site. The fish bone structure helps to visualize and relate the chain of events, which led to the failure of the system. The two-tier Haddon matrix approach helps to analyze the problem and subsequently prescribes preventive steps. The cybernetic approach has been undertaken to establish the relationship among event variables and to identify the ones with most potential. Those event variables in this case study, based on the cybernetic concepts like control responsiveness and controllability salience, are (a) uncontrolled swing of sheet contributing to energy, (b) slippage of sheet from anchor, (c) restricted longitudinal and transverse swing or rotation about the suspension, (d) guilt or uncertainty of the crane driver, (e) safe working practices and environment.

  20. In Search of the Economic Sustainability of Hadron Therapy: The Real Cost of Setting Up and Operating a Hadron Facility

    Energy Technology Data Exchange (ETDEWEB)

    Vanderstraeten, Barbara, E-mail: barbara.vanderstraeten@uzgent.be [Department of Radiotherapy, Ghent University Hospital, Gent (Belgium); Verstraete, Jan [Department of Radiation Oncology, University Hospital Gasthuisberg, Leuven (Belgium); De Croock, Roger [Belgian Hadron Therapy Center Foundation, Brussels (Belgium); De Neve, Wilfried; Lievens, Yolande [Department of Radiotherapy, Ghent University Hospital, Gent (Belgium)

    2014-05-01

    Purpose: To determine the treatment cost and required reimbursement for a new hadron therapy facility, considering different technical solutions and financing methods. Methods and Materials: The 3 technical solutions analyzed are a carbon only (COC), proton only (POC), and combined (CC) center, each operating 2 treatment rooms and assumed to function at full capacity. A business model defines the required reimbursement and analyzes the financial implications of setting up a facility over time; activity-based costing (ABC) calculates the treatment costs per type of patient for a center in a steady state of operation. Both models compare a private, full-cost approach with public sponsoring, only taking into account operational costs. Results: Yearly operational costs range between €10.0M (M = million) for a publicly sponsored POC to €24.8M for a CC with private financing. Disregarding inflation, the average treatment cost calculated with ABC (COC: €29,450; POC: €46,342; CC: €46,443 for private financing; respectively €16,059, €28,296, and €23,956 for public sponsoring) is slightly lower than the required reimbursement based on the business model (between €51,200 in a privately funded POC and €18,400 in COC with public sponsoring). Reimbursement for privately financed centers is very sensitive to a delay in commissioning and to the interest rate. Higher throughput and hypofractionation have a positive impact on the treatment costs. Conclusions: Both calculation methods are valid and complementary. The financially most attractive option of a publicly sponsored COC should be balanced to the clinical necessities and the sociopolitical context.

  1. In Search of the Economic Sustainability of Hadron Therapy: The Real Cost of Setting Up and Operating a Hadron Facility

    International Nuclear Information System (INIS)

    Vanderstraeten, Barbara; Verstraete, Jan; De Croock, Roger; De Neve, Wilfried; Lievens, Yolande

    2014-01-01

    Purpose: To determine the treatment cost and required reimbursement for a new hadron therapy facility, considering different technical solutions and financing methods. Methods and Materials: The 3 technical solutions analyzed are a carbon only (COC), proton only (POC), and combined (CC) center, each operating 2 treatment rooms and assumed to function at full capacity. A business model defines the required reimbursement and analyzes the financial implications of setting up a facility over time; activity-based costing (ABC) calculates the treatment costs per type of patient for a center in a steady state of operation. Both models compare a private, full-cost approach with public sponsoring, only taking into account operational costs. Results: Yearly operational costs range between €10.0M (M = million) for a publicly sponsored POC to €24.8M for a CC with private financing. Disregarding inflation, the average treatment cost calculated with ABC (COC: €29,450; POC: €46,342; CC: €46,443 for private financing; respectively €16,059, €28,296, and €23,956 for public sponsoring) is slightly lower than the required reimbursement based on the business model (between €51,200 in a privately funded POC and €18,400 in COC with public sponsoring). Reimbursement for privately financed centers is very sensitive to a delay in commissioning and to the interest rate. Higher throughput and hypofractionation have a positive impact on the treatment costs. Conclusions: Both calculation methods are valid and complementary. The financially most attractive option of a publicly sponsored COC should be balanced to the clinical necessities and the sociopolitical context

  2. Operational Forecasting and Warning systems for Coastal hazards in Korea

    Science.gov (United States)

    Park, Kwang-Soon; Kwon, Jae-Il; Kim, Jin-Ah; Heo, Ki-Young; Jun, Kicheon

    2017-04-01

    Coastal hazards caused by both Mother Nature and humans cost tremendous social, economic and environmental damages. To mitigate these damages many countries have been running the operational forecasting or warning systems. Since 2009 Korea Operational Oceanographic System (KOOS) has been developed by the leading of Korea Institute of Ocean Science and Technology (KIOST) in Korea and KOOS has been operated in 2012. KOOS is consists of several operational modules of numerical models and real-time observations and produces the basic forecasting variables such as winds, tides, waves, currents, temperature and salinity and so on. In practical application systems include storm surges, oil spills, and search and rescue prediction models. In particular, abnormal high waves (swell-like high-height waves) have occurred in the East coast of Korea peninsula during winter season owing to the local meteorological condition over the East Sea, causing property damages and the loss of human lives. In order to improve wave forecast accuracy even very local wave characteristics, numerical wave modeling system using SWAN is established with data assimilation module using 4D-EnKF and sensitivity test has been conducted. During the typhoon period for the prediction of sever waves and the decision making support system for evacuation of the ships, a high-resolution wave forecasting system has been established and calibrated.

  3. Rescue of foot-and-mouth disease viruses that are pathogenic for cattle from preserved viral RNA samples.

    Directory of Open Access Journals (Sweden)

    Graham J Belsham

    Full Text Available BACKGROUND: Foot and mouth disease is an economically important disease of cloven-hoofed animals including cattle, sheep and pigs. It is caused by a picornavirus, foot-and-mouth disease virus (FMDV, which has a positive sense RNA genome which, when introduced into cells, can initiate virus replication. PRINCIPAL FINDINGS: A system has been developed to rescue infectious FMDV from RNA preparations generated from clinical samples obtained under experimental conditions and then applied to samples collected in the "field". Clinical samples from suspect cases of foot-and-mouth disease (FMD were obtained from within Pakistan and Afghanistan. The samples were treated to preserve the RNA and then transported to National Veterinary Institute, Lindholm, Denmark. Following RNA extraction, FMDV RNA was quantified by real-time RT-PCR and samples containing significant levels of FMDV RNA were introduced into susceptible cells using electroporation. Progeny viruses were amplified in primary bovine thyroid cells and characterized using antigen ELISA and also by RT-PCR plus sequencing. FMD viruses of three different serotypes and multiple lineages have been successfully rescued from the RNA samples. Two of the rescued viruses (of serotype O and Asia 1 were inoculated into bull calves under high containment conditions. Acute clinical disease was observed in each case which spread rapidly from the inoculated calves to in-contact animals. Thus the rescued viruses were highly pathogenic. The availability of the rescued viruses enabled serotyping by antigen ELISA and facilitated genome sequencing. CONCLUSIONS: The procedure described here should improve the characterization of FMDVs circulating in countries where the disease is endemic and thus enhance disease control globally.

  4. The Rubble Rescue Radar (RRR): A low power hand-held microwave device for the detection of trapped human personnel

    International Nuclear Information System (INIS)

    Haddad, W.S.

    1997-01-01

    Each year, innocent human lives are lost in collapsed structures as a result of both natural and man-made disasters. We have developed a prototype device, called the Rubble Rescue Radar (RRR) as a aid to workers trying to locate trapped victims in urban search and rescue operations. The RRR is a motion sensor incorporating Micropower Impulse Radar and is capable of detecting human breathing motions through reinforced concrete. It is lightweight, and designed to be handled by a single operator for local searches in areas where trapped victims are expected. Tests of the first prototype device were conducted on site at LLNL using a mock rubble pile consisting of a reinforced concrete pipe with two concrete floor slabs placed against one side, and random concrete and asphalt debris piled against the other. This arrangement provides safe and easy access for instruments and/or human subjects. Breathing signals of a human subject were recorded with the RRR through one floor slab plus the wall of the pipe, two slabs plus the wall of the pipe, and the random rubble plus the wall of the pipe. Breathing and heart beat signals were also recorded of a seated human subject at a distance of 1 meter with no obstructions. Results and photographs of the experimental work are presented, and a design concept for the next generation device is described

  5. Literature search on the environmental impacts of tar sands operations

    International Nuclear Information System (INIS)

    Birkholz, D.; Prendergast, S.

    1990-09-01

    An extensive review is presented of the literature on the chemistry and biological impacts of current and potential effluents and discharges from oil sands plants on the Athabasca River. The pollutant compounds of interest included polycyclic aromatic hydrocarbons, methyl homologues and metabolites, polycyclic aromatic sulfur heterocycles, polycyclic aromatic nitrogen heterocycles, and naphthenic acids. Topics of interest include chemical methods for identifying and quantitating the above compounds and their metabolites, their sources and release rates, their toxicity to native fish of the Athabasca system, and their degradation in the natural environment. 376 refs., 4 figs., 26 tabs

  6. A GPU Implementation of Local Search Operators for Symmetric Travelling Salesman Problem

    Directory of Open Access Journals (Sweden)

    Juraj Fosin

    2013-06-01

    Full Text Available The Travelling Salesman Problem (TSP is one of the most studied combinatorial optimization problem which is significant in many practical applications in transportation problems. The TSP problem is NP-hard problem and requires large computation power to be solved by the exact algorithms. In the past few years, fast development of general-purpose Graphics Processing Units (GPUs has brought huge improvement in decreasing the applications’ execution time. In this paper, we implement 2-opt and 3-opt local search operators for solving the TSP on the GPU using CUDA. The novelty presented in this paper is a new parallel iterated local search approach with 2-opt and 3-opt operators for symmetric TSP, optimized for the execution on GPUs. With our implementation large TSP problems (up to 85,900 cities can be solved using the GPU. We will show that our GPU implementation can be up to 20x faster without losing quality for all TSPlib problems as well as for our CRO TSP problem.

  7. Consequences of Inadequate Staffing Include Missed Care, Potential Failure to Rescue, and Job Stress and Dissatisfaction.

    Science.gov (United States)

    Simpson, Kathleen Rice; Lyndon, Audrey; Ruhl, Catherine

    2016-01-01

    To evaluate responses of registered nurse members of the Association of Women's Health, Obstetric and Neonatal Nurses (AWHONN) to a survey that sought their recommendations for staffing guidelines and their perceptions of the consequences of inadequate nurse staffing. The goal was to use these member data to inform the work of the AWHONN nurse staffing research team. Secondary analysis of responses to the 2010 AWHONN nurse staffing survey. Online. AWHONN members (N = 884). Review of data from an online survey of AWHONN members through the use of thematic analysis for descriptions of the consequences of inadequate nurse staffing during the childbirth process. Three main themes emerged as consequences of inadequate staffing or being short-staffed: Missed Care, Potential for Failure to Rescue, and Job-Related Stress and Dissatisfaction. These themes are consistent with those previously identified in the literature related to inadequate nurse staffing. Based on the responses from participants in the 2010 AWHONN nurse staffing survey, consequences of inadequate staffing can be quite serious and may put patients at risk for preventable harm. Copyright © 2016 AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses. Published by Elsevier Inc. All rights reserved.

  8. In Search of a Peace Operations Force Structure

    National Research Council Canada - National Science Library

    Kelley, David

    2001-01-01

    ...) strategy, and is unlikely to increase overall force structure in the near-term. Of the seven alternatives presented in the paper, three represent options that could be pursued exclusively within the Department of Defense (DOD...

  9. The Higgs Boson Search and Discovery

    CERN Document Server

    Bernardi, Gregorio

    2016-01-01

    We present a brief account of the search for the Higgs boson at the three major colliders that have operated over the last three decades: LEP, the Tevatron, and the LHC. The experimental challenges encountered stemmed from the distinct event phenomenology as determined by the colliders energy and the possible values for the Higgs boson mass, and from the capability of these colliders to deliver as much collision data as possible to fully explore the mass spectrum within their reach. Focusing more on the hadron collider searches during the last decade, we discuss how the search for the Higgs boson was advanced through mastering the experimental signatures of standard theory backgrounds, through the comprehensive utilization of the features of the detectors involved in the searches, and by means of advanced data analysis techniques. The search culminated in 2012 with the discovery, by the ATLAS and CMS collaborations, of a Higgs-like particle with mass close to 125 GeV, confirmed more recently to have propertie...

  10. Distal mdx muscle groups exhibiting up-regulation of utrophin and rescue of dystrophin-associated glycoproteins exemplify a protected phenotype in muscular dystrophy

    Science.gov (United States)

    Dowling, Paul; Culligan, Kevin; Ohlendieck, Kay

    2002-02-01

    Unique unaffected skeletal muscle fibres, unlike necrotic torso and limb muscles, may pave the way for a more detailed understanding of the molecular pathogenesis of inherited neuromuscular disorders and help to develop new treatment strategies for muscular dystrophies. The sparing of extraocular muscle in Duchenne muscular dystrophy is mostly attributed to the special protective properties of extremely fast-twitching small-diameter fibres, but here we show that distal muscles also represent a particular phenotype that is more resistant to necrosis. Immunoblot analysis of membranes isolated from the well established dystrophic animal model mdx shows that, in contrast to dystrophic limb muscles, the toe musculature exhibits an up-regulation of the autosomal dystrophin homologue utrophin and a concomitant rescue of dystrophin-associated glycoproteins. Thus distal mdx muscle groups provide a cellular system that naturally avoids myofibre degeneration which might be useful in the search for naturally occurring compensatory mechanisms in inherited skeletal muscle diseases.

  11. Development of a Mine Rescue Drilling System (MRDS)

    Energy Technology Data Exchange (ETDEWEB)

    Raymond, David W. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gaither, Katherine N. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Polsky, Yarom [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Knudsen, Steven D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Broome, Scott Thomas [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Su, Jiann-Cherng [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Blankenship, Douglas A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Costin, Laurence S. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2014-06-01

    Sandia National Laboratories (Sandia) has a long history in developing compact, mobile, very high-speed drilling systems and this technology could be applied to increasing the rate at which boreholes are drilled during a mine accident response. The present study reviews current technical approaches, primarily based on technology developed under other programs, analyzes mine rescue specific requirements to develop a conceptual mine rescue drilling approach, and finally, proposes development of a phased mine rescue drilling system (MRDS) that accomplishes (1) development of rapid drilling MRDS equipment; (2) structuring improved web communication through the Mine Safety & Health Administration (MSHA) web site; (3) development of an improved protocol for employment of existing drilling technology in emergencies; (4) deployment of advanced technologies to complement mine rescue drilling operations during emergency events; and (5) preliminary discussion of potential future technology development of specialized MRDS equipment. This phased approach allows for rapid fielding of a basic system for improved rescue drilling, with the ability to improve the system over time at a reasonable cost.

  12. Searching for a Different Understanding of Operational Art

    Science.gov (United States)

    2016-05-26

    real world military scenario. The concept of structuralism began with Ferdinand de Saussure , a Swiss linguist, who examined language as a critical...an object with a word provides a defined meaning to that object. In explaining this relationship between an object and a word, Saussure coined two...New York: Pantheon, 1978). 12 Ferdinand de Saussure , Course in General Linguistics, trans. Wade Baskin (New York: McGraw-Hill, 2011), 65-78. 7

  13. Organizational search and market orientation

    DEFF Research Database (Denmark)

    Sørensen, Hans Eibe; Stieglitz, Nils

    2008-01-01

      Market orientation has evolved into a key construct in the marketing and strategy literature. While much progress has been made in empirical research, the concept lacks a coherent theoretical foundation. Essentially, much prior research has pointed to the role of market-sensing capabilities...... to explain performance differentials among firms (Day, 1994). We open up the black box of market-sensing capabilities by treating the issue of choosing marketing attributes of products as a problem of organizational search. Despite much robust research on organizational search in the strategy......, with their effectiveness depending on organizational and environmental factors. We provide an elaborate outline of the multidimensional aspect of firms' responsive and proactive search processes. First, we highlight the role of organizational aspiration-levels for market orientation. We then investigate the mechanisms...

  14. Quantum walks and search algorithms

    CERN Document Server

    Portugal, Renato

    2013-01-01

    This book addresses an interesting area of quantum computation called quantum walks, which play an important role in building quantum algorithms, in particular search algorithms. Quantum walks are the quantum analogue of classical random walks. It is known that quantum computers have great power for searching unsorted databases. This power extends to many kinds of searches, particularly to the problem of finding a specific location in a spatial layout, which can be modeled by a graph. The goal is to find a specific node knowing that the particle uses the edges to jump from one node to the next. This book is self-contained with main topics that include: Grover's algorithm, describing its geometrical interpretation and evolution by means of the spectral decomposition of the evolution operater Analytical solutions of quantum walks on important graphs like line, cycles, two-dimensional lattices, and hypercubes using Fourier transforms Quantum walks on generic graphs, describing methods to calculate the limiting d...

  15. MARKETING RELATIONSHIP AND TRADING IN THE RELATIONSHIP BETWEEN SERVICE PROVIDERS, HEALTH OPERATORS AND FINAL CUSTOMER: THE SEARCH FOR AN INTEGRATING MODEL

    Directory of Open Access Journals (Sweden)

    Nilda Catalina, Tañski

    2012-01-01

    Full Text Available The marketing relationship finds similarities with the concept of cooperative bargaining, the purpose of this is to find solutions to mutual gains with long-term vision. Within this approach, we sought to build an integrative model of relationship marketing and negotiation in the relationship between service providers, health operators and final customers in the health plan market in Brazil, this relationship is complex, full of conflicts and stagnation. It was first used, first, as an exploratory research of direct observation of the phenomenon referred to relationship marketing, trading and health insurance to increase employment opportunities. Then, the method of data collection was in that environment through online questionnaires using the survey method, in the representative sector. The type of sample used, where n = 217 and the confidence level was 95%, not intentional probabilistic. In the final, it was concluded that the initially proposed model was fully accepted, taking into account the choice of methodology, then achieving the main objective of this study.

  16. Joseph Conrad's tormented Rescue (fantasy).

    Science.gov (United States)

    Freedman, William

    2014-02-01

    Joseph Conrad was a notoriously tormented writer for whom the creative act was often a punishment severe enough to drive him into paralyzing depressions that delayed the completion of his novels, sometimes for years. By far the most agonizing of these projects was The Rescue, a novel he began in 1898, abandoned a year later, tried unsuccessfully to continue several times over the next two decades, but was only able to resume in 1918 and to complete, after another tortured two-year struggle, in 1920. An explanation for this incapacity, that is powerfully suggested by the novel's evocative title and perhaps unintentionally ironic subtitle (A Romance of the Shallows) has not yet been explored. Using Freud's 1910 essay on the rescue fantasy, "Contributions to the Psychology of Love: A Special Type of Choice of Object Made by Men," and Emanuel Berman's instructive revision and expansion of the concept in his 2003 American Imago essay, "Ferenczi, Rescue, and Utopia," I argue that a substantial explanation for Conrad's tormented history with The Rescue is ascribable to its quite remarkably faithful treatment of a rescue fantasy with deep and disabling resonance for its author. More specifically, the difficulty was compounded by the novel's dramatization of the soul-crushing conflict between two such fantasies: one in the service of the masculine ideal of unflinching dedication to a heroic purpose, the other promising satisfaction to the equally potent demands of emotional and sexual desire. Features of Conrad's narrative fit so tightly and consistently with the theory as Freud (and Abraham) proposed and as Berman elaborated it that The Rescue offers itself as one of those rare and reinforcing instances wherein the literary text seems to validate the psychoanalytic theory at least as persuasively as the theory "understands" the text.

  17. Search and Target Acquisition

    National Research Council Canada - National Science Library

    2000-01-01

    ... Concepts and Integration (SCI) Panel 12 (the former RSG-2), on "Camouflage, Concealment and Deception Evaluation Techniques", and that was held in Utrecht, The Netherlands, from 21-23 June 1999...

  18. Search and Tracking of an Unknown Number of Targets by a Team of Autonomous Agents Utilizing Time-evolving Partition Classification

    OpenAIRE

    Wood, Jared Gregory

    2011-01-01

    The advancement of computing technology has enabled the practical development of intelligent autonomous systems. Intelligent autonomous systems can be used to perform difficult sensing tasks. One such sensing task is to search for and track targets over large geographic areas. Searching for and tracking targets over geographic areas has important applications. These applications include search and rescue, boarder patrol, and reconnaissance. Inherent in applications such as these is the need ...

  19. Searching the ASRS Database Using QUORUM Keyword Search, Phrase Search, Phrase Generation, and Phrase Discovery

    Science.gov (United States)

    McGreevy, Michael W.; Connors, Mary M. (Technical Monitor)

    2001-01-01

    To support Search Requests and Quick Responses at the Aviation Safety Reporting System (ASRS), four new QUORUM methods have been developed: keyword search, phrase search, phrase generation, and phrase discovery. These methods build upon the core QUORUM methods of text analysis, modeling, and relevance-ranking. QUORUM keyword search retrieves ASRS incident narratives that contain one or more user-specified keywords in typical or selected contexts, and ranks the narratives on their relevance to the keywords in context. QUORUM phrase search retrieves narratives that contain one or more user-specified phrases, and ranks the narratives on their relevance to the phrases. QUORUM phrase generation produces a list of phrases from the ASRS database that contain a user-specified word or phrase. QUORUM phrase discovery finds phrases that are related to topics of interest. Phrase generation and phrase discovery are particularly useful for finding query phrases for input to QUORUM phrase search. The presentation of the new QUORUM methods includes: a brief review of the underlying core QUORUM methods; an overview of the new methods; numerous, concrete examples of ASRS database searches using the new methods; discussion of related methods; and, in the appendices, detailed descriptions of the new methods.

  20. Improving PHENIX search with Solr, Nutch and Drupal

    International Nuclear Information System (INIS)

    Morrison, Dave; Sourikova, Irina

    2012-01-01

    During its 20 years of R and D, construction and operation the PHENIX experiment at the Relativistic Heavy Ion Collider (RHIC) has accumulated large amounts of proprietary collaboration data that is hosted on many servers around the world and is not open for commercial search engines for indexing and searching. The legacy search infrastructure did not scale well with the fast growing PHENIX document base and produced results inadequate in both precision and recall. After considering the possible alternatives that would provide an aggregated, fast, full text search of a variety of data sources and file formats we decided to use Nutch [1] as a web crawler and Solr [2] as a search engine. To present XML-based Solr search results in a user-friendly format we use Drupal [3] as a web interface to Solr. We describe the experience of building a federated search for a heterogeneous collection of 10 million PHENIX documents with Nutch, Solr and Drupal.

  1. Search in the product market and the real business cycle

    OpenAIRE

    Mathä, Thomas Y.; Pierrard, Olivier

    2009-01-01

    Abstract Abstract Empirical evidence suggests that most firms operate in imperfectly competitive markets. We develop a search-matching model between wholesalers and retailers. Firms face search costs and form long-term relationships. Price bargain results in both wholesaler and retailer markups, which depend on firms? relative bargaining power. We simulate the general equilibrium model and explore the role of product market search frictions for business cycles. We conclu...

  2. Improving PHENIX search with Solr, Nutch and Drupal.

    Science.gov (United States)

    Morrison, Dave; Sourikova, Irina

    2012-12-01

    During its 20 years of R&D, construction and operation the PHENIX experiment at the Relativistic Heavy Ion Collider (RHIC) has accumulated large amounts of proprietary collaboration data that is hosted on many servers around the world and is not open for commercial search engines for indexing and searching. The legacy search infrastructure did not scale well with the fast growing PHENIX document base and produced results inadequate in both precision and recall. After considering the possible alternatives that would provide an aggregated, fast, full text search of a variety of data sources and file formats we decided to use Nutch [1] as a web crawler and Solr [2] as a search engine. To present XML-based Solr search results in a user-friendly format we use Drupal [3] as a web interface to Solr. We describe the experience of building a federated search for a heterogeneous collection of 10 million PHENIX documents with Nutch, Solr and Drupal.

  3. [Analysis on on-site rescue and traumatic features of victims involved in gas explosion accident in Hangzhou].

    Science.gov (United States)

    Wang, X G; Jin, R H; Liu, F P; Han, C M

    2017-10-20

    Objective: To investigate the situations of on-site rescue and traumatic features of victims involved in gas explosion accident in Hangzhou, so as to provide more data support for emergency medical rescues of the similar incidents of massive casualty. Methods: Two medical workers with a certain clinical experience were sent to Hangzhou 120 emergency medical centers to collect data of the on-site rescue on 21st July, 2017, including ambulance call-outs, on-site command and traffic conditions, and on-site triage and evacuation of the victims. They were then sent to the hospitals receiving the victims to investigate the situations of these victims including the general information (such as gender, age, admitted hospitals, and number of admission, discharge, and transferring in the first two weeks after the accident) and injury assessment [such as injury position and type, injury severity evaluation by New Injury Severity Scoring (NISS), and burn severity evaluation for victims with burns]. Results: (1) A total of 15 ambulances reached the accident site for rescue. The traffic and transportation were jammed and interrupted after this accident. On-site triage and distribution were disorderly conducted. (2) Clinical data of 53 victims were collected, including 24 males and 29 females, with the age of 8 to 70 (34±14) years old. They were sent into 6 hospitals in Hangzhou. Two victims died on the day of accident. Up to two weeks after this accident, 28 (52.8%) victims were discharged from the hospitals and received follow-up in outpatient department. Five victims with severe injuries were transferred to the other hospitals. (3) Based on the results of NISS, the injury severities were mild in 29 (54.7%) cases, moderate in 9 (17.0%) cases, serious in 3 (5.7%) cases, and severe in 12 (22.6%) cases. Those 2 dead victims were classified into the severe category due to the highest NISS score of 75. For all of the victims, skin and soft tissue defects were most common. Six (11

  4. Keeping and breeding the rescued Sunda pangolins (Manis javanica) in captivity.

    Science.gov (United States)

    Zhang, Fuhua; Yu, Jiaming; Wu, Shibao; Li, Shaoshan; Zou, Cuiyun; Wang, Qiaoyun; Sun, Ruyong

    2017-12-01

    The Sunda pangolin (Manis javanica Desmarest, 1822) is a Critically Endangered species. Given that this species lacks effective policies for in situ conservation and prevention of poaching in the wild, ex situ conservation and a captive breeding program are urgently needed to save this species from extinction. However, techniques for the maintenance and captive breeding of pangolins have not been well developed. In June 2010, we established the Pangolin Research Base for Artificial Rescue and Conservation Breeding of South China Normal University (PRB-SCNU). To date, a total of 34 Sunda pangolin cubs have been born at PRB-SCNU, 26 of which were captive bred, indicating great progress in keeping and breeding the Sunda pangolin. The techniques for maintenance-including housing, transitioning to an artificial diet, husbandry, and captive breeding-are described in this paper. The purpose of this manuscript is to share our successful experiences and techniques in the maintenance, management, and captive breeding of Sunda pangolins, and to provide guidance and a reference for the captive care and management of Sunda pangolins and other pangolin species. © 2017 Wiley Periodicals, Inc.

  5. 30 CFR 49.17 - Physical requirements for mine rescue team.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Physical requirements for mine rescue team. 49... EDUCATION AND TRAINING MINE RESCUE TEAMS Mine Rescue Teams for Underground Coal Mines § 49.17 Physical requirements for mine rescue team. (a) Each member of a mine rescue team shall be examined annually by a...

  6. Optimal Labour Taxation and Search

    NARCIS (Netherlands)

    Boone, J.; Bovenberg, A.L.

    2000-01-01

    This paper explores the optimal role of the tax system in alleviating labour-market imperfections, raising revenue, and correcting the income distribution. For this purpose, the standard search model of the labour market is extended by introducing non-linear vacancy costs due to scarce

  7. Isoflurane Exposure Rescues Short-term Learning and Memory in Sleep-Disturbed Drosophila melanogaster.

    Directory of Open Access Journals (Sweden)

    Zena Chatila

    2017-10-01

    Full Text Available Sleep is known to play an important role in cognition, learning and memory. As Drosophila melanogaster have stable circadian rhythms and behavioral states similar to those of human sleep, they have been a useful model to investigate the effects of sleep on learning and memory. General anesthesia has been shown to cause cognitive impairments in humans. However, anesthesia also induces a behavioral state similar to sleep and may activate sleep pathways. This study examined learning and memory after an acute exposure of isoflurane in a Drosophila mutant model of restless leg syndrome. There were two possible outcomes: isoflurane (an anesthetic could have impaired cognitive functioning or enhanced learning and memory by activating sleep pathways. Given the acute cognitive impairments often observed postoperatively, we believed the former outcome to be the most likely. Flies with fragmented sleep had impaired performance on an aversive phototaxic suppression learning and memory task compared to wildtype flies. This deficit was rescued with isoflurane exposure, as no differences in learning were observed between mutant and wildtype flies treated with anesthesia. This result suggests that anesthesia exposure can ameliorate impaired learning and memory due to sleep fragmentation. Further investigations are required to determine the type of memory impacted by anesthesia and the mechanisms by which anesthesia induces this effect.

  8. Study on cognitive behavioural coping of intervention and rescue personnel in toxic / flammable / explosive environments

    Directory of Open Access Journals (Sweden)

    Kovacs Izabella

    2017-01-01

    Full Text Available In any given field, the psychological examination represents a prerequisite for ensuring that the work process is properly and appropriately directed towards increasing its efficiency. An important aspect of the psychological examination is to identify risk and protective factors associated with developing and maintaining emotional and behavioural problems. Special conditions resulting from emergency situations are likely to lead to physical and emotional tensions. In some intervention and rescue personnel these are accompanied by mobilization of internal resource, while in others they can generate inadequacy phenomena and symptoms of mental distress. From this perspective, stress is regarded as a result of the marked disparity between environmental requirements and the individual’s response possibilities. To highlight both cognitive and behavioural coping strategies most often used by rescuers trained in NRDI INSEMEX we used two instruments, namely Strategic Approach to Coping Scale SACS and Cognitive Emotion Regulation Questionnaire CERQ. This paper displays the results of the project no. PN 16 43 01 12, study conducted through Nucleu program, implemented with the support of NASR.

  9. Superoxide dismutating molecules rescue the toxic effects of PINK1 and parkin loss.

    Science.gov (United States)

    Biosa, Alice; Sanchez-Martinez, Alvaro; Filograna, Roberta; Terriente-Felix, Ana; Alam, Sarah M; Beltramini, Mariano; Bubacco, Luigi; Bisaglia, Marco; Whitworth, Alexander J

    2018-05-01

    Reactive oxygen species exert important functions in regulating several cellular signalling pathways. However, an excessive accumulation of reactive oxygen species can perturb the redox homeostasis leading to oxidative stress, a condition which has been associated to many neurodegenerative disorders. Accordingly, alterations in the redox state of cells and mitochondrial homeostasis are established hallmarks in both familial and sporadic Parkinson's disease cases. PINK1 and Parkin are two genes which account for a large fraction of autosomal recessive early-onset forms of Parkinson's disease and are now firmly associated to both mitochondria and redox homeostasis. In this study we explored the hypothesis that superoxide anions participate in the generation of the Parkin and PINK1 associated phenotypic effect by testing the capacity of endogenous and exogenous superoxide dismutating molecules to rescue the toxic effects induced by loss of PINK1 or Parkin, in both cellular and fly models. Our results demonstrate the positive effect of an increased level of superoxide dismutase proteins on the pathological phenotypes, both in vitro and in vivo. A more pronounced effectiveness for mitochondrial SOD2 activity points to the superoxide radicals generated in the mitochondrial matrix as the prime suspect in the definition of the observed phenotypes. Moreover, we also demonstrate the efficacy of a SOD-mimetic compound, M40403, to partially ameliorate PINK1/Parkin phenotypes in vitro and in vivo. These results support the further exploration of SOD-mimetic compounds as a therapeutic strategy against Parkinson's disease.

  10. Peripheral Androgen Receptor Gene Suppression Rescues Disease in Mouse Models of Spinal and Bulbar Muscular Atrophy

    Directory of Open Access Journals (Sweden)

    Andrew P. Lieberman

    2014-05-01

    Full Text Available Spinal and bulbar muscular atrophy (SBMA is caused by the polyglutamine androgen receptor (polyQ-AR, a protein expressed by both lower motor neurons and skeletal muscle. Although viewed as a motor neuronopathy, data from patients and mouse models suggest that muscle contributes to disease pathogenesis. Here, we tested this hypothesis using AR113Q knockin and human bacterial artificial chromosome/clone (BAC transgenic mice that express the full-length polyQ-AR and display androgen-dependent weakness, muscle atrophy, and early death. We developed antisense oligonucleotides that suppressed AR gene expression in the periphery but not the CNS after subcutaneous administration. Suppression of polyQ-AR in the periphery rescued deficits in muscle weight, fiber size, and grip strength, reversed changes in muscle gene expression, and extended the lifespan of mutant males. We conclude that polyQ-AR expression in the periphery is an important contributor to pathology in SBMA mice and that peripheral administration of therapeutics should be explored for SBMA patients.

  11. MDM2 inhibition rescues neurogenic and cognitive deficits in a mouse model of fragile X syndrome.

    Science.gov (United States)

    Li, Yue; Stockton, Michael E; Bhuiyan, Ismat; Eisinger, Brian E; Gao, Yu; Miller, Jessica L; Bhattacharyya, Anita; Zhao, Xinyu

    2016-04-27

    Fragile X syndrome, the most common form of inherited intellectual disability, is caused by loss of the fragile X mental retardation protein (FMRP). However, the mechanism remains unclear, and effective treatment is lacking. We show that loss of FMRP leads to activation of adult mouse neural stem cells (NSCs) and a subsequent reduction in the production of neurons. We identified the ubiquitin ligase mouse double minute 2 homolog (MDM2) as a target of FMRP. FMRP regulates Mdm2 mRNA stability, and loss of FMRP resulted in elevated MDM2 mRNA and protein. Further, we found that increased MDM2 expression led to reduced P53 expression in adult mouse NSCs, leading to alterations in NSC proliferation and differentiation. Treatment with Nutlin-3, a small molecule undergoing clinical trials for treating cancer, specifically inhibited the interaction of MDM2 with P53, and rescued neurogenic and cognitive deficits in FMRP-deficient mice. Our data reveal a potential regulatory role for FMRP in the balance between adult NSC activation and quiescence, and identify a potential new treatment for fragile X syndrome. Copyright © 2016, American Association for the Advancement of Science.

  12. Baicalein Rescues Delayed Cooling via Preservation of Akt Activation and Akt-Mediated Phospholamban Phosphorylation

    Directory of Open Access Journals (Sweden)

    Zuohui Shao

    2018-03-01

    Full Text Available Cooling reduces the ischemia/reperfusion (I/R injury seen in sudden cardiac arrest (SCA by decreasing the burst of reactive oxygen species (ROS. Its cardioprotection is diminished when delay in reaching the target temperature occurs. Baicalein, a flavonoid derived from the root of Scutellaria baicalensis Georgi, possesses antioxidant properties. Therefore, we hypothesized that baicalein can rescue cooling cardioprotection when cooling is delayed. Two murine cardiomyocyte models, an I/R model (90 min ischemia/3 h reperfusion and stunning model (30 min ischemia/90 min reperfusion, were used to assess cell survival and contractility, respectively. Cooling (32 °C was initiated either during ischemia or during reperfusion. Cell viability and ROS generation were measured. Cell contractility was evaluated by real-time phase-contrast imaging. Our results showed that cooling reduced cell death and ROS generation, and this effect was diminished when cooling was delayed. Baicalein (25 µM, given either at the start of reperfusion or start of cooling, resulted in a comparable reduction of cell death and ROS production. Baicalein improved phospholamban phosphorylation, contractility recovery, and cell survival. These effects were Akt-dependent. In addition, no synergistic effect was observed with the combined treatments of cooling and baicalein. Our data suggest that baicalein may serve as a novel adjunct therapeutic strategy for SCA resuscitation.

  13. Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia.

    Science.gov (United States)

    Bär, Christian; Povedano, Juan Manuel; Serrano, Rosa; Benitez-Buelga, Carlos; Popkes, Miriam; Formentini, Ivan; Bobadilla, Maria; Bosch, Fatima; Blasco, Maria A

    2016-04-07

    Aplastic anemia is a fatal bone marrow disorder characterized by peripheral pancytopenia and marrow hypoplasia. The disease can be hereditary or acquired and develops at any stage of life. A subgroup of the inherited form is caused by replicative impairment of hematopoietic stem and progenitor cells due to very short telomeres as a result of mutations in telomerase and other telomere components. Abnormal telomere shortening is also described in cases of acquired aplastic anemia, most likely secondary to increased turnover of bone marrow stem and progenitor cells. Here, we test the therapeutic efficacy of telomerase activation by using adeno-associated virus (AAV)9 gene therapy vectors carrying the telomerase Tert gene in 2 independent mouse models of aplastic anemia due to short telomeres (Trf1- and Tert-deficient mice). We find that a high dose of AAV9-Tert targets the bone marrow compartment, including hematopoietic stem cells. AAV9-Tert treatment after telomere attrition in bone marrow cells rescues aplastic anemia and mouse survival compared with mice treated with the empty vector. Improved survival is associated with a significant increase in telomere length in peripheral blood and bone marrow cells, as well as improved blood counts. These findings indicate that telomerase gene therapy represents a novel therapeutic strategy to treat aplastic anemia provoked or associated with short telomeres. © 2016 by The American Society of Hematology.

  14. Long-Distance Rescue and Slow Extinction Dynamics Govern Multiscale Metapopulations.

    Science.gov (United States)

    Huth, Géraldine; Haegeman, Bart; Pitard, Estelle; Munoz, François

    2015-10-01

    Rare long-distance dispersal is known to be critical for species dynamics, but how the interplay between short- and long-distance colonization influences regional persistence in a fragmented habitat remains poorly understood. We propose a metapopulation model that combines local colonization within habitat islands and long-distance colonization between islands. We study how regional occupancy dynamics are affected by the multiscale colonization process. We find that the island size distribution (ISD) is a key driver of the long-term occupancy dynamics. When the ISD is heterogeneous-that is, when the size of islands is variable-we show that extinction dynamics become very slow. We demonstrate that this behavior is unrelated to the well-known extinction debt near the critical extinction threshold. Hence, this finding questions the equivalence between extinction debt and critical transitions in the context of metapopulation collapse. Furthermore, we show that long-distance colonization can rescue small islands from extinction and sustain a steady regional occupancy. These results provide novel theoretical and practical insights into extinction dynamics and persistence in fragmented habitats and are thus relevant for the design of conservation strategies.

  15. Neuroprotective and nootropic drug noopept rescues α-synuclein amyloid cytotoxicity.

    Science.gov (United States)

    Jia, Xueen; Gharibyan, Anna L; Öhman, Anders; Liu, Yonggang; Olofsson, Anders; Morozova-Roche, Ludmilla A

    2011-12-16

    Parkinson's disease is a common neurodegenerative disorder characterized by α-synuclein (α-Syn)-containing Lewy body formation and selective loss of dopaminergic neurons in the substantia nigra. We have demonstrated the modulating effect of noopept, a novel proline-containing dipeptide drug with nootropic and neuroprotective properties, on α-Syn oligomerization and fibrillation by using thioflavin T fluorescence, far-UV CD, and atomic force microscopy techniques. Noopept does not bind to a sterically specific site in the α-Syn molecule as revealed by heteronuclear two-dimensional NMR analysis, but due to hydrophobic interactions with toxic amyloid oligomers, it prompts their rapid sequestration into larger fibrillar amyloid aggregates. Consequently, this process rescues the cytotoxic effect of amyloid oligomers on neuroblastoma SH-SY5Y cells as demonstrated by using cell viability assays and fluorescent staining of apoptotic and necrotic cells and by assessing the level of intracellular oxidative stress. The mitigating effect of noopept against amyloid oligomeric cytotoxicity may offer additional benefits to the already well-established therapeutic functions of this new pharmaceutical. Copyright © 2011 Elsevier Ltd. All rights reserved.

  16. In between exclusion and rescue. An anthropologic study about the implementation of programs socio-educative

    Directory of Open Access Journals (Sweden)

    María Paula Montesino

    2009-03-01

    Full Text Available In this paper we analyse how social regulations, implicated in public and educative polices, use the idea of educative inclusion from a psychologism point of view of poverty while are mentioned structural and “objective” causes. Our research and fieldwork on the “Programa Todos a Estudiar” shows, in one hand, how the exclusion effects related to the low self esteem grows/rise in teenagers that had abandoned their studies and in the other hand, a quasi-missionary praxis related to the use of categories such as rescue, recuperation , etc. to mention the socio-educative intervention that different persons involved in the implementation of the Programme does. We assure, as a hypothesis on this paper, that what this individuals persons “does” and “says” produce a contradictory paradox: it is assumed that the school is the best —and unique— place for those teenagers and, at the same time, those educative institutions are considered as the central producers of the processes that promote the social exclusion.

  17. Postnatal soluble FGFR3 therapy rescues achondroplasia symptoms and restores bone growth in mice.

    Science.gov (United States)

    Garcia, Stéphanie; Dirat, Béatrice; Tognacci, Thomas; Rochet, Nathalie; Mouska, Xavier; Bonnafous, Stéphanie; Patouraux, Stéphanie; Tran, Albert; Gual, Philippe; Le Marchand-Brustel, Yannick; Gennero, Isabelle; Gouze, Elvire

    2013-09-18

    Achondroplasia is a rare genetic disease characterized by abnormal bone development, resulting in short stature. It is caused by a single point mutation in the gene coding for fibroblast growth factor receptor 3 (FGFR3), which leads to prolonged activation upon ligand binding. To prevent excessive intracellular signaling and rescue the symptoms of achondroplasia, we have developed a recombinant protein therapeutic approach using a soluble form of human FGFR3 (sFGFR3), which acts as a decoy receptor and prevents FGF from binding to mutant FGFR3. sFGFR3 was injected subcutaneously to newborn Fgfr3(ach/+) mice-the mouse model of achondroplasia-twice per week throughout the growth period during 3 weeks. Effective maturation of growth plate chondrocytes was restored in bones of treated mice, with a dose-dependent enhancement of skeletal growth in Fgfr3(ach/+) mice. This resulted in normal stature and a significant decrease in mortality and associated complications, without any evidence of toxicity. These results describe a new approach for restoring bone growth and suggest that sFGFR3 could be a potential therapy for children with achondroplasia and related disorders.

  18. Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency

    Science.gov (United States)

    Yan, Meng; Zhang, Kaiping; Shi, Yanhui; Feng, Lifang; Lv, Lin; Li, Baoxin

    2015-01-01

    Berberine (BBR), an isoquinoline alkaloid mainly isolated from plants of Berberidaceae family, is extensively used to treat gastrointestinal infections in clinics. It has been reported that BBR can block human ether-a-go-go-related gene (hERG) potassium channel and inhibit its membrane expression. The hERG channel plays crucial role in cardiac repolarization and is the target of diverse proarrhythmic drugs. Dysfunction of hERG channel can cause long QT syndrome. However, the regulatory mechanisms of BBR effects on hERG at cell membrane level remain unknown. This study was designed to investigate in detail how BBR decreased hERG expression on cell surface and further explore its pharmacological rescue strategies. In this study, BBR decreases caveolin-1 expression in a concentration-dependent manner in human embryonic kidney 293 (HEK293) cells stably expressing hERG channel. Knocking down the basal expression of caveolin-1 alleviates BBR-induced hERG reduction. In addition, we found that aromatic tyrosine (Tyr652) and phenylalanine (Phe656) in S6 domain mediate the long-term effect of BBR on hERG by using mutation techniques. Considering both our previous and present work, we propose that BBR reduces hERG membrane stability with multiple mechanisms. Furthermore, we found that fexofenadine and resveratrol shorten action potential duration prolongated by BBR, thus having the potential effects of alleviating the cardiotoxicity of BBR. PMID:26543354

  19. A dynamic lattice searching method with rotation operation for optimization of large clusters

    International Nuclear Information System (INIS)

    Wu Xia; Cai Wensheng; Shao Xueguang

    2009-01-01

    Global optimization of large clusters has been a difficult task, though much effort has been paid and many efficient methods have been proposed. During our works, a rotation operation (RO) is designed to realize the structural transformation from decahedra to icosahedra for the optimization of large clusters, by rotating the atoms below the center atom with a definite degree around the fivefold axis. Based on the RO, a development of the previous dynamic lattice searching with constructed core (DLSc), named as DLSc-RO, is presented. With an investigation of the method for the optimization of Lennard-Jones (LJ) clusters, i.e., LJ 500 , LJ 561 , LJ 600 , LJ 665-667 , LJ 670 , LJ 685 , and LJ 923 , Morse clusters, silver clusters by Gupta potential, and aluminum clusters by NP-B potential, it was found that both the global minima with icosahedral and decahedral motifs can be obtained, and the method is proved to be efficient and universal.

  20. Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice.

    Science.gov (United States)

    Liu, Karen J; Arron, Joseph R; Stankunas, Kryn; Crabtree, Gerald R; Longaker, Michael T

    2007-03-01

    Glycogen synthase kinase-3beta (GSK-3beta) has integral roles in a variety of biological processes, including development, diabetes, and the progression of Alzheimer's disease. As such, a thorough understanding of GSK-3beta function will have a broad impact on human biology and therapeutics. Because GSK-3beta interacts with many different pathways, its specific developmental roles remain unclear. We have discovered a genetic requirement for GSK-3beta in midline development. Homozygous null mice display cleft palate, incomplete fusion of the ribs at the midline and bifid sternum as well as delayed sternal ossification. Using a chemically regulated allele of GSK-3beta (ref. 6), we have defined requirements for GSK-3beta activity during discrete temporal windows in palatogenesis and skeletogenesis. The rapamycin-dependent allele of GSK-3beta produces GSK-3beta fused to a tag, FRB* (FKBP/rapamycin binding), resulting in a rapidly destabilized chimaeric protein. In the absence of drug, GSK-3beta(FRB)*(/FRB)* mutants appear phenotypically identical to GSK-3beta-/- mutants. In the presence of drug, GSK-3betaFRB* is rapidly stabilized, restoring protein levels and activity. Using this system, mutant phenotypes were rescued by restoring endogenous GSK-3beta activity during two distinct periods in gestation. This technology provides a powerful tool for defining windows of protein function during development.

  1. The moral obligation to be vaccinated: utilitarianism, contractualism, and collective easy rescue.

    Science.gov (United States)

    Giubilini, Alberto; Douglas, Thomas; Savulescu, Julian

    2018-02-10

    We argue that individuals who have access to vaccines and for whom vaccination is not medically contraindicated have a moral obligation to contribute to the realisation of herd immunity by being vaccinated. Contrary to what some have claimed, we argue that this individual moral obligation exists in spite of the fact that each individual vaccination does not significantly affect vaccination coverage rates and therefore does not significantly contribute to herd immunity. Establishing the existence of a moral obligation to be vaccinated (both for adults and for children) despite the negligible contribution each vaccination can make to the realisation of herd immunity is important because such moral obligation would strengthen the justification for coercive vaccination policies. We show that two types of arguments-namely a utilitarian argument based on Parfit's Principle of Group Beneficence and a contractualist argument-can ground an individual moral obligation to be vaccinated, in spite of the imperceptible contribution that any single vaccination makes to vaccine coverage rates. We add a further argument for a moral obligation to be vaccinated that does not require embracing problematic comprehensive moral theories such as utilitarianism or contractualism. The argument is based on a "duty of easy rescue" applied to collectives, which grounds a collective moral obligation to realise herd immunity, and on a principle of fairness in the distribution of the burdens that must be borne to realise herd immunity.

  2. Human cathepsin L rescues the neurodegeneration and lethality incathepsin B/L double deficient mice

    Energy Technology Data Exchange (ETDEWEB)

    Sevenich, Lisa; Pennacchio, Len A.; Peters, Christoph; Reinheckel, Thomas

    2006-01-09

    Cathepsin B (CTSB) and cathepsin L (CTSL) are two widelyexpressed cysteine proteases thought to predominantly reside withinlysosomes. Functional analysis of CTSL in humans is complicated by theexistence of two CTSL-like homologues (CTSL and CTSL2), in contrast tomice which contain only one CTSL enzyme. Thus transgenic expression ofhuman CTSL in CTSL deficient mice provides an opportunity to study the invivo functions of this human protease without interference by its highlyrelated homologue. While mice with single gene deficiencies for murineCTSB or CTSL survive without apparent neuromuscular impairment, murineCTSB/CTSL double deficient mice display degeneration of cerebellarPurkinje cells and neurons of the cerebral cortex, resulting in severehypotrophy, motility defects, and lethality during their third to fourthweek of life. Here we show that expression of human CTSL through agenomic transgene results in widespread expression of human CTSL in themouse which is capable of rescuing the lethality found in CTSB/CTSLdouble-deficient animals. Human CTSL is expressed in the brain of thesecompound mutants predominantly in neurons of the cerebral cortex and inPurkinje cells of the cerebellum, where it appears to prevent neuronalcell death.

  3. Hesitant Fuzzy Linguistic Preference Utility Set and Its Application in Selection of Fire Rescue Plans

    Science.gov (United States)

    Si, Guangsen; Xu, Zeshui

    2018-01-01

    Hesitant fuzzy linguistic term set provides an effective tool to represent uncertain decision information. However, the semantics corresponding to the linguistic terms in it cannot accurately reflect the decision-makers’ subjective cognition. In general, different decision-makers’ sensitivities towards the semantics are different. Such sensitivities can be represented by the cumulative prospect theory value function. Inspired by this, we propose a linguistic scale function to transform the semantics corresponding to linguistic terms into the linguistic preference values. Furthermore, we propose the hesitant fuzzy linguistic preference utility set, based on which, the decision-makers can flexibly express their distinct semantics and obtain the decision results that are consistent with their cognition. For calculations and comparisons over the hesitant fuzzy linguistic preference utility sets, we introduce some distance measures and comparison laws. Afterwards, to apply the hesitant fuzzy linguistic preference utility sets in emergency management, we develop a method to obtain objective weights of attributes and then propose a hesitant fuzzy linguistic preference utility-TOPSIS method to select the best fire rescue plan. Finally, the validity of the proposed method is verified by some comparisons of the method with other two representative methods including the hesitant fuzzy linguistic-TOPSIS method and the hesitant fuzzy linguistic-VIKOR method. PMID:29614019

  4. Kinetic and structural evidences on human prolidase pathological mutants suggest strategies for enzyme functional rescue.

    Directory of Open Access Journals (Sweden)

    Roberta Besio

    Full Text Available Prolidase is the only human enzyme responsible for the digestion of iminodipeptides containing proline or hydroxyproline at their C-terminal end, being a key player in extracellular matrix remodeling. Prolidase deficiency (PD is an intractable loss of function disease, characterized by mutations in the prolidase gene. The exact causes of activity impairment in mutant prolidase are still unknown. We generated three recombinant prolidase forms, hRecProl-231delY, hRecProl-E412K and hRecProl-G448R, reproducing three mutations identified in homozygous PD patients. The enzymes showed very low catalytic efficiency, thermal instability and changes in protein conformation. No variation of Mn(II cofactor affinity was detected for hRecProl-E412K; a compromised ability to bind the cofactor was found in hRecProl-231delY and Mn(II was totally absent in hRecProl-G448R. Furthermore, local structure perturbations for all three mutants were predicted by in silico analysis. Our biochemical investigation of the three causative alleles identified in perturbed folding/instability, and in consequent partial prolidase degradation, the main reasons for enzyme inactivity. Based on the above considerations we were able to rescue part of the prolidase activity in patients' fibroblasts through the induction of Heath Shock Proteins expression, hinting at new promising avenues for PD treatment.

  5. A partial structural and functional rescue of a retinitis pigmentosa model with compacted DNA nanoparticles.

    Directory of Open Access Journals (Sweden)

    Xue Cai

    Full Text Available Previously we have shown that compacted DNA nanoparticles can drive high levels of transgene expression after subretinal injection in the mouse eye. Here we delivered compacted DNA nanoparticles containing a therapeutic gene to the retinas of a mouse model of retinitis pigmentosa. Nanoparticles containing the wild-type retinal degeneration slow (Rds gene were injected into the subretinal space of rds(+/- mice on postnatal day 5. Gene expression was sustained for up to four months at levels up to four times higher than in controls injected with saline or naked DNA. The nanoparticles were taken up into virtually all photoreceptors and mediated significant structural and biochemical rescue of the disease without histological or functional evidence of toxicity. Electroretinogram recordings showed that nanoparticle-mediated gene transfer restored cone function to a near-normal level in contrast to transfer of naked plasmid DNA. Rod function was also improved. These findings demonstrate that compacted DNA nanoparticles represent a viable option for development of gene-based interventions for ocular diseases and obviate major barriers commonly encountered with non-viral based therapies.

  6. Endoplasmic reticulum stress in amelogenesis imperfecta and phenotypic rescue using 4-phenylbutyrate.

    Science.gov (United States)

    Brookes, Steven J; Barron, Martin J; Boot-Handford, Ray; Kirkham, Jennifer; Dixon, Michael J

    2014-05-01

    Inherited diseases caused by genetic mutations can arise due to loss of protein function. Alternatively, mutated proteins may mis-fold, impairing endoplasmic reticulum (ER) trafficking, causing ER stress and triggering the unfolded protein response (UPR). The UPR attempts to restore proteostasis but if unsuccessful drives affected cells towards apoptosis. Previously, we reported that in mice, the p.Tyr64His mutation in the enamel extracellular matrix (EEM) protein amelogenin disrupts the secretory pathway in the enamel-forming ameloblasts, resulting in eruption of malformed tooth enamel that phenocopies human amelogenesis imperfecta (AI). Defective amelogenin post-secretory self-assembly and processing within the developing EEM has been suggested to underlie the pathogenesis of X chromosome-linked AI. Here, we challenge this concept by showing that AI pathogenesis associated with the p.Tyr64His amelogenin mutation involves ameloblast apoptosis induced by ER stress. Furthermore, we show that 4-phenylbutyrate can rescue the enamel phenotype in affected female mice by promoting cell survival over apoptosis such that they are able to complete enamel formation despite the presence of the mutation, offering a potential therapeutic option for patients with this form of AI and emphasizing the importance of ER stress in the pathogenesis of this inherited conformational disease.

  7. Rescue ALPPS: Intraoperative Conversion to ALPPS during Synchronous Resection of Rectal Cancer and Liver Metastasis

    Directory of Open Access Journals (Sweden)

    Terence Jackson

    2014-01-01

    Full Text Available Future liver remnant (FLR is the most important deciding factor in planning for liver resection. Portal vein embolization (PVE was first introduced in the 1980s to induce liver hypertrophy, enabling removal of multiple/bilobar tumors. PVE was later combined with sequential hepatectomies with the aim of allowing the liver remnant to hypertrophy (15–20% between procedures. However, the interval between the two procedures (3–8 weeks put patients at risk for disease progression. With portal vein ligation alone or when combined with sequential hepatectomy, there is also a risk for inadequate liver hypertrophy because of intrahepatic portal collaterals leading to a high (19–30% dropout rate. The ALPPS procedure (associating liver partition and portal vein ligation for staged hepatectomy was recently developed as a feasible means to perform extensive/bilobar liver resections. It produces rapid, enormous hypertrophy of the remnant, making previously unresectable lesions resectable. Indications for ALPPS include any extensive liver resection with inadequate FLR. Here we present a novel indication for ALPPS as a rescue when inadequate FLR was faced intraoperatively, during a simultaneous resection of rectal primary and liver metastasis.

  8. Teaching Holocaust Rescue: A Problematic Pedagogy

    Science.gov (United States)

    Lindquist, David H.

    2008-01-01

    Determining how to teach about rescue during the Holocaust presents many dilemmas to teachers as they plan Holocaust curricula. Rescue is often overemphasized, and faulty perspectives about rescuers and their actions may cause students to develop distorted views about this aspect of Holocaust history. This article explores several factors that…

  9. Stochastic local search foundations and applications

    CERN Document Server

    Hoos, Holger H; Stutzle, Thomas

    2004-01-01

    Stochastic local search (SLS) algorithms are among the most prominent and successful techniques for solving computationally difficult problems in many areas of computer science and operations research, including propositional satisfiability, constraint satisfaction, routing, and scheduling. SLS algorithms have also become increasingly popular for solving challenging combinatorial problems in many application areas, such as e-commerce and bioinformatics. Hoos and Stützle offer the first systematic and unified treatment of SLS algorithms. In this groundbreaking new book, they examine the general concepts and specific instances of SLS algorithms and carefully consider their development, analysis and application. The discussion focuses on the most successful SLS methods and explores their underlying principles, properties, and features. This book gives hands-on experience with some of the most widely used search techniques, and provides readers with the necessary understanding and skills to use this powerful too...

  10. Gas Concentration Prediction Based on the Measured Data of a Coal Mine Rescue Robot

    Directory of Open Access Journals (Sweden)

    Xiliang Ma

    2016-01-01

    Full Text Available The coal mine environment is complex and dangerous after gas accident; then a timely and effective rescue and relief work is necessary. Hence prediction of gas concentration in front of coal mine rescue robot is an important significance to ensure that the coal mine rescue robot carries out the exploration and search and rescue mission. In this paper, a gray neural network is proposed to predict the gas concentration 10 meters in front of the coal mine rescue robot based on the gas concentration, temperature, and wind speed of the current position and 1 meter in front. Subsequently the quantum genetic algorithm optimization gray neural network parameters of the gas concentration prediction method are proposed to get more accurate prediction of the gas concentration in the roadway. Experimental results show that a gray neural network optimized by the quantum genetic algorithm is more accurate for predicting the gas concentration. The overall prediction error is 9.12%, and the largest forecasting error is 11.36%; compared with gray neural network, the gas concentration prediction error increases by 55.23%. This means that the proposed method can better allow the coal mine rescue robot to accurately predict the gas concentration in the coal mine roadway.

  11. A high-fat diet and NAD+ activate sirt1 to rescue premature aging in cockayne syndrome

    DEFF Research Database (Denmark)

    Scheibye-Knudsen, Morten; Mitchell, Sarah J.; Fang, Evandro F.

    2014-01-01

    -fat, caloric-restricted, or resveratrol-supplemented diet. High-fat feeding rescued the metabolic, transcriptomic, and behavioral phenotypes of Csbm/m mice. Furthermore, premature aging in CS mice, nematodes, and human cells results from aberrant PARP activation due to deficient DNA repair leading to decreased......Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in genes encoding the DNA repair proteins CS group A or B (CSA or CSB). Since dietary interventions can alter neurodegenerative processes, Csbm/m mice were given a high...... SIRT1 activity and mitochondrial dysfunction. Notably, β-hydroxybutyrate levels are increased by the high-fat diet, and β-hydroxybutyrate, PARP inhibition, or NAD+ supplementation can activate SIRT1 and rescue CS-associated phenotypes. Mechanistically, CSB can displace activated PARP1 from damaged DNA...

  12. Rescuing Quadratic Inflation

    CERN Document Server

    Ellis, John; Sueiro, Maria

    2014-01-01

    Inflationary models based on a single scalar field $\\phi$ with a quadratic potential $V = \\frac{1}{2} m^2 \\phi^2$ are disfavoured by the recent Planck constraints on the scalar index, $n_s$, and the tensor-to-scalar ratio for cosmological density perturbations, $r_T$. In this paper we study how such a quadratic inflationary model can be rescued by postulating additional fields with quadratic potentials, such as might occur in sneutrino models, which might serve as either curvatons or supplementary inflatons. Introducing a second scalar field reduces but does not remove the pressure on quadratic inflation, but we find a sample of three-field models that are highly compatible with the Planck data on $n_s$ and $r_T$. We exhibit a specific three-sneutrino example that is also compatible with the data on neutrino mass difference and mixing angles.

  13. Evaluating the Use of Auditory Systems to Improve Performance in Combat Search and Rescue

    Science.gov (United States)

    2012-03-01

    basis through Wide Area Work Flow (WAWF) in advance to assist the company in managing its cash flow commitments with respect to the agreement. WSARC... Nvidia Quad Fx56000 Win XP Pro 32 Bit 4 - BOXX Technologies Dual Xenon E5420 2.5 Ghz Nvidia Quad Fx56000 Win XP Pro 32 Bit Other Servers 1

  14. Integrating Unmanned Aerial Vehicles (UAVs) With Current Combat Search and Rescue (CSAR) Doctrine

    National Research Council Canada - National Science Library

    Altieri, Jayson

    2003-01-01

    0300 hours (Zulu) somewhere north of Baghdad Major Chris Foster, call sign BACH-21, was flying a CAP mission supporting two flights of Air Guard F-16s attacking an Iraqi armor division retreating south towards Baghdad...

  15. L-leucine partially rescues translational and developmental defects associated with zebrafish models of Cornelia de Lange syndrome.

    Science.gov (United States)

    Xu, Baoshan; Sowa, Nenja; Cardenas, Maria E; Gerton, Jennifer L

    2015-03-15

    Cohesinopathies are human genetic disorders that include Cornelia de Lange syndrome (CdLS) and Roberts syndrome (RBS) and are characterized by defects in limb and craniofacial development as well as mental retardation. The developmental phenotypes of CdLS and other cohesinopathies suggest that mutations in the structure and regulation of the cohesin complex during embryogenesis interfere with gene regulation. In a previous project, we showed that RBS was associated with highly fragmented nucleoli and defects in both ribosome biogenesis and protein translation. l-leucine stimulation of the mTOR pathway partially rescued translation in human RBS cells and development in zebrafish models of RBS. In this study, we investigate protein translation in zebrafish models of CdLS. Our results show that phosphorylation of RPS6 as well as 4E-binding protein 1 (4EBP1) was reduced in nipbla/b, rad21 and smc3-morphant embryos, a pattern indicating reduced translation. Moreover, protein biosynthesis and rRNA production were decreased in the cohesin morphant embryo cells. l-leucine partly rescued protein synthesis and rRNA production in the cohesin morphants and partially restored phosphorylation of RPS6 and 4EBP1. Concomitantly, l-leucine treatment partially improved cohesinopathy embryo development including the formation of craniofacial cartilage. Interestingly, we observed that alpha-ketoisocaproate (α-KIC), which is a keto derivative of leucine, also partially rescued the development of rad21 and nipbla/b morphants by boosting mTOR-dependent translation. In summary, our results suggest that cohesinopathies are caused in part by defective protein synthesis, and stimulation of the mTOR pathway through l-leucine or its metabolite α-KIC can partially rescue development in zebrafish models for CdLS. © The Author 2014. Published by Oxford University Press.

  16. 46 CFR 133.175 - Survival craft and rescue boat equipment.

    Science.gov (United States)

    2010-10-01

    ... line 1 2 1 2 15 Instruction card 1 1 17 Knife 1,3 1 1 1 1 18 Ladder 1 1 19 Mirror, signalling 1 1 20... Not required for inflated or rigid-inflated rescue boats. 3 A hatchet counts towards this requirement...

  17. The woman as problem and solution : Analysis of a gender equality initiative within the Swedish Rescue Services

    OpenAIRE

    Grip, Lena; Engström, Lars-Gunnar; Krekula, Clary; Karlsson, Stefan

    2016-01-01

    The aim of this article is to study how problem definitions of gender equality affect the possible outcomes of gender equality initiatives. The Swedish Municipal Rescue Services were chosen as the empirical example because they offer a workplace where women are greatly under-represented despite years of gender equality efforts. The article analyses how reasoning around gender equality shapes and constructs problem formulations around gender and equality. This article contributes to the debate...

  18. Self-Rescue Mask Training

    CERN Multimedia

    2013-01-01

    Nine new self-rescue mask instructors have been trained since early 2013, which provides CERN with a total of 26 self-rescue mask instructors to date. This will allow us to meet the increasing training needs caused by the Long Shut Down LS1.   The self-rescue mask instructors have trained 1650 persons in 2012 and about 500 persons since the beginning of the year on how to wear the masks properly. We thank all the instructors and all the persons that made this training possible. Please remember that the self-rescue masks training sessions are scheduled as follows: Basic course: Tuesday and Thursday mornings (2 sessions – 8.30 AM and 10.30 AM), duration:  1.30 hour, in French and English – registration via CERN online training catalogue – Course code 077Y00. Refresher training : Monday mornings (2 sessions – 8.30 AM and 10.30 AM), duration: 1.30 hour , in French and English – registration via CERN online training catalogue &...

  19. The role of non-genetic inheritance in evolutionary rescue: epigenetic buffering, heritable bet hedging and epigenetic traps.

    Science.gov (United States)

    O'Dea, Rose E; Noble, Daniel W A; Johnson, Sheri L; Hesselson, Daniel; Nakagawa, Shinichi

    2016-01-01

    Rapid environmental change is predicted to compromise population survival, and the resulting strong selective pressure can erode genetic variation, making evolutionary rescue unlikely. Non-genetic inheritance may provide a solution to this problem and help explain the current lack of fit between purely genetic evolutionary models and empirical data. We hypothesize that epigenetic modifications can facilitate evolutionary rescue through 'epigenetic buffering'. By facilitating the inheritance of novel phenotypic variants that are generated by environmental change-a strategy we call 'heritable bet hedging'-epigenetic modifications could maintain and increase the evolutionary potential of a population. This process may facilitate genetic adaptation by preserving existing genetic variation, releasing cryptic genetic variation and/or facilitating mutations in functional loci. Although we show that examples of non-genetic inheritance are often maladaptive in the short term, accounting for phenotypic variance and non-adaptive plasticity may reveal important evolutionary implications over longer time scales. We also discuss the possibility that maladaptive epigenetic responses may be due to 'epigenetic traps', whereby evolutionarily novel factors (e.g. endocrine disruptors) hack into the existing epigenetic machinery. We stress that more ecologically relevant work on transgenerational epigenetic inheritance is required. Researchers conducting studies on transgenerational environmental effects should report measures of phenotypic variance, so that the possibility of both bet hedging and heritable bet hedging can be assessed. Future empirical and theoretical work is required to assess the relative importance of genetic and epigenetic variation, and their interaction, for evolutionary rescue.

  20. Simultaneous Iliac Vein Bovine Pericardial Patch Venoplasty and Creation of PTFE Lower Limb Arteriovenous Fistula Graft for Rescue Vascular Access.

    Science.gov (United States)

    Meecham, Lewis; Fisher, Owain; Kirby, George; Evans, Richard; Buxton, Pauline; Legge, Jocelyn; Rajagopalan, Sriram; Asquith, John; Pherwani, Arun

    2016-10-01

    We present a case of external iliac vein patch venoplasty to accommodate rescue vascular access via a polytetrafluoroethylene loop arteriovenous fistula graft (AVG) for a patient with multiple central venous stenoses. A 35-year-old female with anti-glomerular basement membrane antibody disease required rescue vascular access for hemodialysis. Repeated occlusion and/or thrombosis of long-term central venous access cannulae, to facilitate dialysis, had caused stenosis of brachiocephalic veins: right external iliac vein and occlusion of the left common iliac vein. A previous right brachiobasilic fistula had occluded within 1 year. No other upper limb options for arteriovenous fistula (AVF) were available. A right external iliac vein bovine patch angioplasty concurrently with a polytetrafluoroethylene AV graft between common femoral artery and common femoral vein was performed to restore venous patency and allow rescue dialysis access. At 3-year follow-up, the fistula remains widely patent with 2 L/min flow rates and no recurrent stenosis to the treated iliac vein. She has not required any further surgical or interventional radiological procedures to maintain fistula or central venous patency. Central venous stenosis or occlusion is common for patients requiring dialysis, especially those with multiple previous long-term central venous cannulations. If restriction of outflow is present, AVF may fail. Venous patch angioplasty in these cases is a successful technique, allowing AVF formation and long-term patency. Central venous stenosis can be treated successfully with patch venoplasty to accommodate AVF/AVG formation for rescue vascular access; this is a potentially lifesaving intervention for patients requiring dialysis. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. KNOWLEDGE UNDERSTANDING AND ADVANCED SEARCHING

    Directory of Open Access Journals (Sweden)

    R Vidya

    2017-04-01

    Full Text Available It’s a comprehensive fact that millions of people around the world surf the Internet for want of answers for their questions. Generally, the questions are asked in the form of Searching or direct questions which follow perfect ontological directions. It is important that the system understands the questions in the right sense and can provide the best answer for all the questions raised in the web forum. One such pragmatic method is required which is expected to provide optimum solution to achieve best answers for questions that not only percepts language but also follows perfect ontological information in accordance with the cyber law. This Proposed Model presents a new dynamic model called Knowledge Understanding and Advance Searching (KUAS that studies the importance of Smart Question Answering with other question answering engines like START and proves to give the optimal solution compared to them.

  2. Sequence adaptations during growth of rescued classical swine fever viruses in cell culture and within infected pigs

    DEFF Research Database (Denmark)

    Hadsbjerg, Johanne; Friis, Martin Barfred; Fahnøe, Ulrik

    2016-01-01

    RNA could be detected. However, the animals inoculated with these mutant viruses seroconverted against CSFV. Thus, these mutant viruses were highly attenuated in vivo. All 4 rescued viruses were also passaged up to 20 times in cell culture. Using full genome sequencing, the same two adaptations within......Classical swine fever virus (CSFV) causes an economically important disease of swine. Four different viruses were rescued from full-length cloned cDNAs derived from the Paderborn strain of CSFV. Three of these viruses had been modified by mutagenesis (with 7 or 8 nt changes) within stem 2...... each of four independent virus populations were observed that restored the coding sequence to that of the parental field strain. These adaptations occurred with different kinetics. The combination of reverse genetics and in depth, full genome sequencing provides a powerful approach to analyse virus...

  3. The RESCueH Programme

    DEFF Research Database (Denmark)

    Søgaard Nielsen, Anette; Nielsen, Bent; Andersen, Kjeld

    2016-01-01

    Excessive alcohol consumption is one of the most important lifestyle factors affecting the disease burden in the Western world. The results of treatment in daily practice are modest at best. The aim of the RESCueH programme is to develop and evaluate methods, which are as practice-near as possible...

  4. A longitudinal study of posttraumatic stress symptoms and their predictors in rescue workers after a firework factory disaster.

    Science.gov (United States)

    Ask, Elklit; Gudmundsdottir, Drifa

    2014-01-01

    This is a follow up study on rescue workers participating in the primary rescue during and immediately after the explosion of a firework factory. We aimed to estimate the possible PTSD prevalence at five and 18 months post disaster, determining if the level of PTSD symptoms at 18 months could be predicted from factors measured at five months. We included measures of posttraumatic symptoms, social support, locus of control and demographic questions. The possible PTSD prevalence rose from 1.6% (n = 465) at five months post disaster to 3.1% (n = 130) at 18 months. A hierarchical linear regression predicted 59% of PTSD symptoms variance at 18 months post disaster. In the final regression, somatization explained the greatest part of the symptom variance (42%), followed by locus of control (29%) and major life events prior to and right after the disaster (23%). Rescue workers seemed to be relatively robust to traumatic exposure: The prevalence of possible PTSD in our study was even lower than previous studies, probably because of the less severe consequences of the disaster studied. Furthermore, we found that PTSD symptom level at 18 months post disaster was highly predicted by psychological factors, particularly by somatization. However, further investigations of traumatic responding are required in this population.

  5. Rescuing and Sharing Historical Vegetation Data for Ecological Analysis: The California Vegetation Type Mapping Project

    Directory of Open Access Journals (Sweden)

    Maggi Kelly

    2016-10-01

    Full Text Available Research efforts that synthesize historical and contemporary ecological data with modeling approaches improve our understanding of the complex response of species, communities, and landscapes to changing biophysical conditions through time and in space. Historical ecological data are particularly important in this respect. There are remaining barriers that limit such data synthesis, and technological improvements that make multiple diverse datasets more readily available for integration and synthesis are needed. This paper presents one case study of the Wieslander Vegetation Type Mapping project in California and highlights the importance of rescuing, digitizing and sharing historical datasets. We review the varied ecological uses of the historical collection: the vegetation maps have been used to understand legacies of land use change and plan for the future; the plot data have been used to examine changes to chaparral and forest communities around the state and to predict community structure and shifts under a changing climate; the photographs have been used to understand changing vegetation structure; and the voucher specimens in combination with other specimen collections have been used for large scale distribution modeling efforts. The digitization and sharing of the data via the web has broadened the scope and scale of the types of analysis performed. Yet, additional research avenues can be pursued using multiple types of VTM data, and by linking VTM data with contemporary data. The digital VTM collection is an example of a data infrastructure that expands the potential of large scale research through the integration and synthesis of data drawn from numerous data sources; its journey from analog to digital is a cautionary tale of the importance of finding historical data, digitizing it with best practices, linking it with other datasets, and sharing it with the research community.

  6. Individual Search and Social Networks

    OpenAIRE

    Sanjeev Goyal; Stephanie Rosenkranz; Utz Weitzel; Vincent Buskens

    2014-01-01

    The explosion in online social networks motivates an enquiry into their structure and their welfare effects. A central feature of these networks is information sharing: online social networks lower the cost of getting information from others. These lower costs affect the attractiveness of individual search vis-a-vis a reliance on social networks. The paper reports the findings of an experiment on these effects. Our experiment shows that online networks can have large effects. Information acqu...

  7. Rescue of Synaptic Phenotypes and Spatial Memory in Young Fragile X Mice.

    Science.gov (United States)

    Sun, Miao-Kun; Hongpaisan, Jarin; Alkon, Daniel L

    2016-05-01

    Fragile X syndrome (FXS) is characterized by synaptic immaturity, cognitive impairment, and behavioral changes. The disorder is caused by transcriptional shutdown in neurons of thefragile X mental retardation 1gene product, fragile X mental retardation protein. Fragile X mental retardation protein is a repressor of dendritic mRNA translation and its silencing leads to dysregulation of synaptically driven protein synthesis and impairments of intellect, cognition, and behavior, and FXS is a disorder that currently has no effective therapeutics. Here, young fragile X mice were treated with chronic bryostatin-1, a relatively selective protein kinase Cεactivator, which induces synaptogenesis and synaptic maturation/repair. Chronic treatment with bryostatin-1 rescues young fragile X mice from the disorder phenotypes, including normalization of most FXS abnormalities in 1) hippocampal brain-derived neurotrophic factor expression, 2) postsynaptic density-95 levels, 3) transformation of immature dendritic spines to mature synapses, 4) densities of the presynaptic and postsynaptic membranes, and 5) spatial learning and memory. The therapeutic effects were achieved without downregulation of metabotropic glutamate receptor (mGluR) 5 in the hippocampus and are more dramatic than those of a late-onset treatment in adult fragile X mice. mGluR5 expression was in fact lower in fragile X mice and its expression was restored with the bryostatin-1 treatment. Our results show that synaptic and cognitive function of young FXS mice can be normalized through pharmacological treatment without downregulation of mGluR5 and that bryostatin-1-like agents may represent a novel class of drugs to treat fragile X mental retardation at a young age and in adults. Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics.

  8. Minocycline Rescues from Zinc-Induced Nigrostriatal Dopaminergic Neurodegeneration: Biochemical and Molecular Interventions.

    Science.gov (United States)

    Kumar, Vinod; Singh, Brajesh Kumar; Chauhan, Amit Kumar; Singh, Deepali; Patel, Devendra Kumar; Singh, Chetna

    2016-07-01

    Accumulation of zinc (Zn) in dopaminergic neurons is implicated in Parkinson's disease (PD), and microglial activation plays a critical role in toxin-induced Parkinsonism. Oxidative stress is accused in Zn-induced dopaminergic neurodegeneration; however, its connection with microglial activation is still not known. This study was undertaken to elucidate the role and underlying mechanism of microglial activation in Zn-induced nigrostriatal dopaminergic neurodegeneration. Male Wistar rats were treated intraperitoneally with/without zinc sulphate (20 mg/kg) in the presence/absence of minocycline (30 mg/kg), a microglial activation inhibitor, for 2-12 weeks. While neurobehavioral and biochemical indexes of PD and number of dopaminergic neurons were reduced, the number of microglial cells was increased in the substantia nigra of the Zn-exposed animals. Similarly, Zn elevated lipid peroxidation (LPO) and activities of superoxide dismutase (SOD) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase; however, catalase activity was reduced. Besides, Zn increased an association of NADPH oxidase subunit p67(phox) with membrane, cytochrome c release from the mitochondria and cleavage of pro-caspase 3. Zn attenuated the expression of tyrosine hydroxylase (TH) and vesicular monoamine transporter-2 (VMAT-2) while augmented the expression of dopamine transporter (DAT) and heme oxygenase-1 (HO-1). Minocycline alleviated Zn-induced behavioural impairments, loss of TH-positive neurons, activated microglial cells and biochemical indexes and modulated the expression of studied genes/proteins towards normalcy. The results demonstrate that minocycline reduces the number of activated microglial cells and oxidative stress, which rescue from Zn-induced changes in the expression of monoamine transporter and nigrostriatal dopaminergic neurodegeneration.

  9. Better Nurse Autonomy Decreases the Odds of 30-Day Mortality and Failure to Rescue

    Science.gov (United States)

    Rao, Aditi D.; Kumar, Aparna; McHugh, Matthew

    2017-01-01

    Research Purpose Autonomy is essential to professional nursing practice and is a core component of good nurse work environments. The primary objective of this study was to examine the relationship between nurse autonomy and 30-day mortality and failure to rescue (FTR) in a hospitalized surgical population. Study Design This study was a secondary analysis of cross-sectional data. It included data from three sources: patient discharge data from state administrative databases, a survey of nurses from four states, and the American Hospital Association annual survey from 2006–2007. Methods Survey responses from 20,684 staff nurses across 570 hospitals were aggregated to the hospital level to assess autonomy measured by a standardized scale. Logistic regression models were used to estimate the relationship between nurse autonomy and 30-day mortality and FTR. Patient comorbidities, surgery type, and other hospital characteristics were included as controls. Findings Greater nurse autonomy at the hospital level was significantly associated with lower odds of 30-day mortality and FTR for surgical patients even after accounting for patient risk and structural hospital characteristics. Each additional point on the nurse autonomy scale was associated with approximately 19% lower odds of 30-day mortality (p autonomy place their surgical patients at an increased risk for mortality and FTR. Clinical Relevance Patients receiving care within institutions that promote high levels of nurse autonomy have a lower risk for death within 30 days and complications leading to death within 30 days. Hospitals can actively take steps to encourage nurse autonomy to positively influence patient outcomes. PMID:28094907

  10. Pentamidine rescues contractility and rhythmicity in a Drosophila model of myotonic dystrophy heart dysfunction

    Directory of Open Access Journals (Sweden)

    Mouli Chakraborty

    2015-12-01

    Full Text Available Up to 80% of individuals with myotonic dystrophy type 1 (DM1 will develop cardiac abnormalities at some point during the progression of their disease, the most common of which is heart blockage of varying degrees. Such blockage is characterized by conduction defects and supraventricular and ventricular tachycardia, and carries a high risk of sudden cardiac death. Despite its importance, very few animal model studies have focused on the heart dysfunction in DM1. Here, we describe the characterization of the heart phenotype in a Drosophila model expressing pure expanded CUG repeats under the control of the cardiomyocyte-specific driver GMH5-Gal4. Morphologically, expression of 250 CUG repeats caused abnormalities in the parallel alignment of the spiral myofibrils in dissected fly hearts, as revealed by phalloidin staining. Moreover, combined immunofluorescence and in situ hybridization of Muscleblind and CUG repeats, respectively, confirmed detectable ribonuclear foci and Muscleblind sequestration, characteristic features of DM1, exclusively in flies expressing the expanded CTG repeats. Similarly to what has been reported in humans with DM1, heart-specific expression of toxic RNA resulted in reduced survival, increased arrhythmia, altered diastolic and systolic function, reduced heart tube diameters and reduced contractility in the model flies. As a proof of concept that the fly heart model can be used for in vivo testing of promising therapeutic compounds, we fed flies with pentamidine, a compound previously described to improve DM1 phenotypes. Pentamidine not only released Muscleblind from the CUG RNA repeats and reduced ribonuclear formation in the Drosophila heart, but also rescued heart arrhythmicity and contractility, and improved fly survival in animals expressing 250 CUG repeats.

  11. Chronic melatonin treatment rescues electrophysiological and neuromorphological deficits in a mouse model of Down syndrome.

    Science.gov (United States)

    Corrales, Andrea; Vidal, Rebeca; García, Susana; Vidal, Verónica; Martínez, Paula; García, Eva; Flórez, Jesús; Sanchez-Barceló, Emilio J; Martínez-Cué, Carmen; Rueda, Noemí

    2014-01-01

    The Ts65Dn mouse (TS), the most commonly used model of Down syndrome (DS), exhibits several key phenotypic characteristics of this condition. In particular, these animals present hypocellularity in different areas of their CNS due to impaired neurogenesis and have alterations in synaptic plasticity that compromise their cognitive performance. In addition, increases in oxidative stress during adulthood contribute to the age-related progression of cognitive and neuronal deterioration. We have previously demonstrated that chronic melatonin treatment improves learning and memory and reduces cholinergic neurodegeneration in TS mice. However, the molecular and physiological mechanisms that mediate these beneficial cognitive effects are not yet fully understood. In this study, we analyzed the effects of chronic melatonin treatment on different mechanisms that have been proposed to underlie the cognitive impairments observed in TS mice: reduced neurogenesis, altered synaptic plasticity, enhanced synaptic inhibition and oxidative damage. Chronic melatonin treatment rescued both impaired adult neurogenesis and the decreased density of hippocampal granule cells in trisomic mice. In addition, melatonin administration reduced synaptic inhibition in TS mice by increasing the density and/or activity of glutamatergic synapses in the hippocampus. These effects were accompanied by a full recovery of hippocampal LTP in trisomic animals. Finally, melatonin treatment decreased the levels of lipid peroxidation in the hippocampus of TS mice. These results indicate that the cognitive-enhancing effects of melatonin in adult TS mice could be mediated by the normalization of their electrophysiological and neuromorphological abnormalities and suggest that melatonin represents an effective treatment in retarding the progression of DS neuropathology. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  12. Classifying Vessels Operating in the South China Sea by Origin with the Automatic Identification System

    Science.gov (United States)

    2018-03-01

    p. 5) means to track voyage and safety related information in real time. Over time, massive amounts of information related to maritime operations... safety related messages from land based stations, navigation aids, and search and rescue (SAR) crews. All AIS messages are intended to encourage open...United States is the South China Sea. Eight countries, China, Taiwan, the Philippines, Brunei, Indonesia, Malaysia , Singapore, and Vietnam

  13. Repurposing and Rescuing of Mibefradil, an Antihypertensive, for Cancer: A Case Study.

    Science.gov (United States)

    Krouse, Andrew J; Gray, Lloyd; Macdonald, Timothy; McCray, John

    2015-12-01

    The expanding "valley of death" in drug development is leaving potentially life-saving new chemical entities and molecular targets fallow. This situation is forcing early-stage companies to think creatively about moving their technologies forward, especially as institutional investors show more interest in later stages of development. Drug repurposing, a strategy to examine existing drugs for therapeutic value against different diseases, is an emerging method to bring an off-market drug back onto the market. Tau Therapeutics LLC identified the role of T-type calcium channel blockers (Cav3) in cancer proliferation, but the company was unable to attract funding while having both a nonvalidated drug target and new chemical entities. To change the risk profile of the company, Tau set out to repurpose the known Cav3 drug mibefradil as a proof of concept for the treatment of cancer. Mibefradil was launched for hypertension in the 1990s but withdrawn because of drug-drug interactions. A new sequential combination treatment, termed Interlaced Therapy™, uses short-term administration of mibefradil to enhance the overall therapeutic potential of conventional anticancer agents. Mibefradil is currently in a phase Ib clinical trial with the National Cancer Institute (NCI) Adult Brain Tumor Consortium. Mibefradil has been repurposed from an abandoned antihypertensive to a targeted solid tumor treatment, and it has been rescued from drug-drug interactions by using short-term dose exposure. Tau is using the early success of mibefradil as a proof of concept to build a platform technology of Cav3 blockers for broad antitumor applications in combination with new targeted cancer therapies, well-established chemotherapies, and radiation.

  14. Medical Operational Challenges in the Expedition 16 Landing and Recovery

    Science.gov (United States)

    Moynihan, S.; Johnston, S. L.; Ilcus, L. S.; Shevchenko, V.

    2009-01-01

    On April 19, 2008 the crew of Expedition 16 left the International Space Station and returned to earth via their Soyuz TMA-11 capsule after 192 days on orbit. Their capsule experienced the second consecutive and third ballistic reentry in the last 10 TMA recoveries and landed approximately 260 miles (420 km) from the prime landing site. Issues: The purpose of this presentation will be to describe, not only the typical medical operational challenges faced by Flight Surgeons recovering a long duration crew from space, but also address the unique challenges that existed with the Expedition 16 landing and crew recovery. Nominal Soyuz recovery challenges include remote recovery sites with crew exposures to sleep shifting and fatigue, dehydration, hypothermia and hyperthermia, and rotational, sustained, and impact g-forces. These environmental factors coupled with the patho-physiologic neuro-vestibular and orthostatic intolerance changes that occur secondary to the crews reintroduction into the earth s gravity field will be detailed. Additional challenges that were unique to this expedition included a ballistic reentry with higher g-loads, the presence of fire outside of the capsule on landing, a contingency medical event of a ground support personnel, and loss of communications with the crew just prior to landing and during recovery operations. Conclusions: In spite of these unique challenges the Russian Search and Rescue Forces and Medical Support personnel along with U.S. Medical Support performed well together. Possible improvements in training and coordination will be discussed.

  15. ROLE AND IMPORTANCE OF SEARCH ENGINE OPTIMIZATION

    OpenAIRE

    Gurneet Kaur

    2017-01-01

    Search Engines are an indispensible platform for users all over the globe to search for relevant information online. Search Engine Optimization (SEO) is the exercise of improving the position of a website in search engine rankings, for a chosen set of keywords. SEO is divided into two parts: On-Page and Off-Page SEO. In order to be successful, both the areas require equal attention. This paper aims to explain the functioning of the search engines along with the role and importance of search e...

  16. How to improve your PubMed/MEDLINE searches: 3. advanced searching, MeSH and My NCBI.

    Science.gov (United States)

    Fatehi, Farhad; Gray, Leonard C; Wootton, Richard

    2014-03-01

    Although the basic PubMed search is often helpful, the results may sometimes be non-specific. For more control over the search process you can use the Advanced Search Builder interface. This allows a targeted search in specific fields, with the convenience of being able to select the intended search field from a list. It also provides a history of your previous searches. The search history is useful to develop a complex search query by combining several previous searches using Boolean operators. For indexing the articles in MEDLINE, the NLM uses a controlled vocabulary system called MeSH. This standardised vocabulary solves the problem of authors, researchers and librarians who may use different terms for the same concept. To be efficient in a PubMed search, you should start by identifying the most appropriate MeSH terms and use them in your search where possible. My NCBI is a personal workspace facility available through PubMed and makes it possible to customise the PubMed interface. It provides various capabilities that can enhance your search performance.

  17. Employed and unemployed job search methods: Australian evidence on search duration, wages and job stability

    OpenAIRE

    Colin Green

    2012-01-01

    This paper examines the use and impact of job search methods of both unemployed and employed job seekers. Informal job search methods are associated with relativel high level of job exit and shorter search duration. Job exists through the public employment agency (PEA) display positive duration dependence for the unemployed. This may suggest that the PEA is used as a job search method of last resort. Informal job search methods have lower associated duration in search and higher wages than th...

  18. Search Analytics: Automated Learning, Analysis, and Search with Open Source

    Science.gov (United States)

    Hundman, K.; Mattmann, C. A.; Hyon, J.; Ramirez, P.

    2016-12-01

    The sheer volume of unstructured scientific data makes comprehensive human analysis impossible, resulting in missed opportunities to identify relationships, trends, gaps, and outliers. As the open source community continues to grow, tools like Apache Tika, Apache Solr, Stanford's DeepDive, and Data-Driven Documents (D3) can help address this challenge. With a focus on journal publications and conference abstracts often in the form of PDF and Microsoft Office documents, we've initiated an exploratory NASA Advanced Concepts project aiming to use the aforementioned open source text analytics tools to build a data-driven justification for the HyspIRI Decadal Survey mission. We call this capability Search Analytics, and it fuses and augments these open source tools to enable the automatic discovery and extraction of salient information. In the case of HyspIRI, a hyperspectral infrared imager mission, key findings resulted from the extractions and visualizations of relationships from thousands of unstructured scientific documents. The relationships include links between satellites (e.g. Landsat 8), domain-specific measurements (e.g. spectral coverage) and subjects (e.g. invasive species). Using the above open source tools, Search Analytics mined and characterized a corpus of information that would be infeasible for a human to process. More broadly, Search Analytics offers insights into various scientific and commercial applications enabled through missions and instrumentation with specific technical capabilities. For example, the following phrases were extracted in close proximity within a publication: "In this study, hyperspectral images…with high spatial resolution (1 m) were analyzed to detect cutleaf teasel in two areas. …Classification of cutleaf teasel reached a users accuracy of 82 to 84%." Without reading a single paper we can use Search Analytics to automatically identify that a 1 m spatial resolution provides a cutleaf teasel detection users accuracy of 82

  19. Google and the culture of search

    CERN Document Server

    Hillis, Ken; Jarrett, Kylie

    2013-01-01

    What did you do before Google? The rise of Google as the dominant Internet search provider reflects a generationally-inflected notion that everything that matters is now on the Web, and should, in the moral sense of the verb, be accessible through search. In this theoretically nuanced study of search technology's broader implications for knowledge production and social relations, the authors shed light on a culture of search in which our increasing reliance on search engines influences not only the way we navigate, classify, and evaluate Web content, but also how we think about ourselves and the world around us, online and off. Ken Hillis, Michael Petit, and Kylie Jarrett seek to understand the ascendancy of search and its naturalization by historicizing and contextualizing Google's dominance of the search industry, and suggest that the contemporary culture of search is inextricably bound up with a metaphysical longing to manage, order, and categorize all knowledge. Calling upon this nexus between political e...

  20. Job Search and Earnings Mobility

    OpenAIRE

    David Turchick

    2014-01-01

    Measures of social mobility provide an extra dimension for testing job search models. The present note tests the dynamic model in [Acemoglu, D., 1999. Changes in unemployment and wage inequality: an alternative theory and some evidence. American Economic Review 89, 1259-1278] with respect to Fields’ mobility-as-an-equalizer-of-longer-term-incomes index. The 1980s in the U.S. were not only a period of raising inequality, but also one of longer-term earnings becoming even more unequal than shor...

  1. Higgs and SUSY searches at future colliders

    Indian Academy of Sciences (India)

    ... searches at future colliders, particularly comparing and contrasting the capabilities of LHC and next linear collider (NLC), including the aspects of Higgs searches in supersymmetric theories. I will also discuss how the search and study of sparticles other than the Higgs can be used to give information about the parameters ...

  2. Precision Rescue Behavior in North American Ants

    Directory of Open Access Journals (Sweden)

    Katherine Taylor

    2013-07-01

    Full Text Available Altruistic behavior, in which one individual provides aid to another at some cost to itself, is well documented. However, some species engage in a form of altruism, called rescue, that places the altruist in immediate danger. Here we investigate one such example, namely rescuing victims captured by predators. In a field experiment with two North American ant species, Tetramorium sp. E and Prenolepis imparis, individuals were held in artificial snares simulating capture. T. sp. E, but not P. imparis, exhibited digging, pulling, and snare biting, the latter precisely targeted to the object binding the victim. These results are the first to document precision rescue in a North American ant species; moreover, unlike rescue in other ants, T. sp. E rescues conspecifics from different colonies, mirroring their atypical social behavior, namely the lack of aggression between non-nestmate (heterocolonial conspecifics. In a second, observational study designed to demonstrate rescue from an actual predator, T. sp. E victims were dropped into an antlion's pit and the behavior of a single rescuer was observed. Results showed that T. sp. E not only attempted to release the victim, but also risked attacking the predator, suggesting that precision rescue may play an important role in this species' antipredator behavior.

  3. Body mass index and body composition among rescue firefighters personnel in Selangor, Malaysia

    Science.gov (United States)

    Rahimi, Nor Atiqah; Sedek, Razalee; Teh, Arnida Hani

    2016-11-01

    Obesity is a major public health problem in general population and there is no exception for firefighters. This disorder is definitely a burden for firefighters as they needed to be physically fit in order to work in dangerous situation and extinguishing fires. The purposes of this study were to determine physical characteristics and body composition among Malaysian Firefighters (MF) and to explore their association. This cross-sectional study involved 330 rescue firefighters aged between 20-50 years old from nine different districts in Selangor conducted between August and November 2015. Anthropometric measurements included height, weight and waist circumference (WC). Body composition was measured using bioelectrical impedance. The mean height, weight, body mass index (BMI), WC and body fat percentage were 169.4±5.3 cm, 74.5±12.2 kg, 25.9±3.82 kg/m2, 90.7±48.3 cm and 25.8±6.2 % respectively. The results also showed that 0.6% of them were underweight, 41.5% were normal, 44.8% were overweight and 13% were obese. The percentage of 34.8% firefighters with WC values of more than 90 cm means that they were at greater risk to have cardiovascular and diabetes disease. Body composition analysis showed that 75.5% of the subjects have high body fat level, 19.7% subjects were in healthy range but only 4.8% were considered as lean subjects. BMI was highly correlated with weight (r=0.917, p<0.01), WC (r=0.858, p<0.01) and body fat percentage (r=0.757, <0.01). Body fat percentage also showed to have a high correlation with BMI (r=0.757, p<0.01) and WC (r=0.693, p<0.01). Furthermore, overweight and obesity were found to be more prevalent among firefighters personnel of older age, married, less educated and have longer duration of services. It can be concluded that more than half of the firefighter personnel were either overweight or obese and 35% of them were at greater risk of having non-communicable diseases. This study provides useful information and serves as a source of

  4. In search of the lost Century. The imperial claim to the rescue of the 19th Century during the consolidation of the Franco Era

    Directory of Open Access Journals (Sweden)

    Ferrán GALLEGO

    2016-07-01

    Full Text Available This article sets up the role of historical essay in the constitution of Spanish nationalist discourse in the years of early civil postwar and initial consolidation of Franco’s regime. It explores the transition of studies basically related to imperial Spain to those examining decadence. Moreover, it evaluates the irruption of a new intellectual consideration of Spanish Nineteenth Century. These last elements —the new analysis of modern decadence and the vindication of regeneration criticism—, were congruent with an intellectual and political need of Francoism. This was the urgency of strengthening its singularity and its will of permanence,when the destruction of international fascist experience could be seen as a contingent circumstance opening way for the recovering of the Spanish universal enterprise essence.

  5. Combining the power of searching and querying

    NARCIS (Netherlands)

    Cohen, S.; Kanza, Y.; Kogan, Y.A.; Nutt, W.; Sagiv, Y.; Serebrenik, A.; Etzion, O.; Scheuermann, P.

    2000-01-01

    EquiX is a search language for XML that combines the power of querying with the simplicity of searching. Requirements for search languages are discussed and it is shown that EquiX meets the necessary criteria. Both a graphical abstract syntax and a formal concrete syntax are presented for EquiX

  6. Oxidative stress induced by zearalenone in porcine granulosa cells and its rescue by curcumin in vitro.

    Directory of Open Access Journals (Sweden)

    Xunsi Qin

    Full Text Available Oxidative stress (OS, as a signal of aberrant intracellular mechanisms, plays key roles in maintaining homeostasis for organisms. The occurrence of OS due to the disorder of normal cellular redox balance indicates the overproduction of reactive oxygen species (ROS and/or deficiency of antioxidants. Once the balance is broken down, repression of oxidative stress is one of the most effective ways to alleviate it. Ongoing studies provide remarkable evidence that oxidative stress is involved in reproductive toxicity induced by various stimuli, such as environmental toxicants and food toxicity. Zearalenone (ZEA, as a toxic compound existing in contaminated food products, is found to induce mycotoxicosis that has a significant impact on the reproduction of domestic animals, especially pigs. However, there is no information about how ROS and oxidative stress is involved in the influence of ZEA on porcine granulosa cells, or whether the stress can be rescued by curcumin. In this study, ZEA-induced effect on porcine granulosa cells was investigated at low concentrations (15 μM, 30 μM and 60 μM. In vitro ROS levels, the mRNA level and activity of superoxide dismutase, glutathione peroxidase and catalase were obtained. The results showed that in comparison with negative control, ZEA increased oxidative stress with higher ROS levels, reduced the expression and activity of antioxidative enzymes, increased the intensity of fluorogenic probes 2', 7'-Dichlorodihydrofluorescin diacetate and dihydroethidium in flow cytometry assay and fluorescence microscopy. Meanwhile, the activity of glutathione (GSH did not change obviously following 60 μM ZEA treatment. Furthermore, the underlying protective mechanisms of curcumin on the ZEA-treated porcine granulosa cells were investigated. The data revealed that curcumin pre-treatment significantly suppressed ZEA-induced oxidative stress. Collectively, porcine granulosa cells were sensitive to ZEA, which may induce

  7. Cross-disciplinary working in the sciences and humanities: historical data rescue activities in Southeast Asia and beyond

    Directory of Open Access Journals (Sweden)

    Fiona Williamson

    2016-11-01

    Full Text Available Abstract This paper argues that more work is needed to facilitate cross-disciplinary collaborations by scholars across the physical sciences and humanities to improve Data Rescue Activities (DARE. Debate over the scale and potential impact of anthropogenic global warming is one of the dominant narratives of the twenty-first century. Predicting future climates and determining how environment and society might be affected by climate change are global issues of social, economic and political importance. They require responses from different research communities and necessitate closer inter-disciplinary working relationships for an integrated approach. Improving the datasets required for long-term climate models is an important part of this process. Establishing a multi-disciplinary dialogue and approach to DARE activities is increasingly being recognised as the best way to achieve this. This paper focuses on the recovery of the long-term instrumental weather observations used for models and reconstructions of the climate over the past two-hundred years. Written from the perspective of an historian working in the field, it does not seek to explore the reconstructions themselves but the process of data gathering, advocating a closer working relationship between the arts, social sciences, and sciences to extend the geographic and temporal coverage of extant datasets. This is especially important for regions where data gaps exist currently. First, it will offer a justification for extending data recovery activities for Southeast Asia and the China Seas region. Second, it will offer a brief overview of the data recovery projects currently operating in that area and the typesof historic source material that are used. Third, it will explore the work currently being undertaken for Southeast Asia and China under the Atmospheric Circulation Reconstructions over the Earth initiative as an example of a successful cross-disciplinary program. Finally, it will

  8. Cross-disciplinary working in the sciences and humanities: historical data rescue activities in Southeast Asia and beyond

    Science.gov (United States)

    Williamson, Fiona

    2016-12-01

    This paper argues that more work is needed to facilitate cross-disciplinary collaborations by scholars across the physical sciences and humanities to improve Data Rescue Activities (DARE). Debate over the scale and potential impact of anthropogenic global warming is one of the dominant narratives of the twenty-first century. Predicting future climates and determining how environment and society might be affected by climate change are global issues of social, economic and political importance. They require responses from different research communities and necessitate closer inter-disciplinary working relationships for an integrated approach. Improving the datasets required for long-term climate models is an important part of this process. Establishing a multi-disciplinary dialogue and approach to DARE activities is increasingly being recognised as the best way to achieve this. This paper focuses on the recovery of the long-term instrumental weather observations used for models and reconstructions of the climate over the past two-hundred years. Written from the perspective of an historian working in the field, it does not seek to explore the reconstructions themselves but the process of data gathering, advocating a closer working relationship between the arts, social sciences, and sciences to extend the geographic and temporal coverage of extant datasets. This is especially important for regions where data gaps exist currently. First, it will offer a justification for extending data recovery activities for Southeast Asia and the China Seas region. Second, it will offer a brief overview of the data recovery projects currently operating in that area and the typesof historic source material that are used. Third, it will explore the work currently being undertaken for Southeast Asia and China under the Atmospheric Circulation Reconstructions over the Earth initiative as an example of a successful cross-disciplinary program. Finally, it will argue the importance of

  9. Deleterious ABCA7 mutations and transcript rescue mechanisms in early onset Alzheimer's disease.

    Science.gov (United States)

    De Roeck, Arne; Van den Bossche, Tobi; van der Zee, Julie; Verheijen, Jan; De Coster, Wouter; Van Dongen, Jasper; Dillen, Lubina; Baradaran-Heravi, Yalda; Heeman, Bavo; Sanchez-Valle, Raquel; Lladó, Albert; Nacmias, Benedetta; Sorbi, Sandro; Gelpi, Ellen; Grau-Rivera, Oriol; Gómez-Tortosa, Estrella; Pastor, Pau; Ortega-Cubero, Sara; Pastor, Maria A; Graff, Caroline; Thonberg, Håkan; Benussi, Luisa; Ghidoni, Roberta; Binetti, Giuliano; de Mendonça, Alexandre; Martins, Madalena; Borroni, Barbara; Padovani, Alessandro; Almeida, Maria Rosário; Santana, Isabel; Diehl-Schmid, Janine; Alexopoulos, Panagiotis; Clarimon, Jordi; Lleó, Alberto; Fortea, Juan; Tsolaki, Magda; Koutroumani, Maria; Matěj, Radoslav; Rohan, Zdenek; De Deyn, Peter; Engelborghs, Sebastiaan; Cras, Patrick; Van Broeckhoven, Christine; Sleegers, Kristel

    2017-09-01

    Premature termination codon (PTC) mutations in the ATP-Binding Cassette, Sub-Family A, Member 7 gene (ABCA7) have recently been identified as intermediate-to-high penetrant risk factor for late-onset Alzheimer's disease (LOAD). High variability, however, is observed in downstream ABCA7 mRNA and protein expression, disease penetrance, and onset age, indicative of unknown modifying factors. Here, we investigated the prevalence and disease penetrance of ABCA7 PTC mutations in a large early onset AD (EOAD)-control cohort, and examined the effect on transcript level with comprehensive third-generation long-read sequencing. We characterized the ABCA7 coding sequence with next-generation sequencing in 928 EOAD patients and 980 matched control individuals. With MetaSKAT rare variant association analysis, we observed a fivefold enrichment (p = 0.0004) of PTC mutations in EOAD patients (3%) versus controls (0.6%). Ten novel PTC mutations were only observed in patients, and PTC mutation carriers in general had an increased familial AD load. In addition, we observed nominal risk reducing trends for three common coding variants. Seven PTC mutations were further analyzed using targeted long-read cDNA sequencing on an Oxford Nanopore MinION platform. PTC-containing transcripts for each investigated PTC mutation were observed at varying proportion (5-41% of the total read count), implying incomplete nonsense-mediated mRNA decay (NMD). Furthermore, we distinguished and phased several previously unknown alternative splicing events (up to 30% of transcripts). In conjunction with PTC mutations, several of these novel ABCA7 isoforms have the potential to rescue deleterious PTC effects. In conclusion, ABCA7 PTC mutations play a substantial role in EOAD, warranting genetic screening of ABCA7 in genetically unexplained patients. Long-read cDNA sequencing revealed both varying degrees of NMD and transcript-modifying events, which may influence ABCA7 dosage, disease severity, and may

  10. Social Search: A Taxonomy of, and a User-Centred Approach to, Social Web Search

    Science.gov (United States)

    McDonnell, Michael; Shiri, Ali

    2011-01-01

    Purpose: The purpose of this paper is to introduce the notion of social search as a new concept, drawing upon the patterns of web search behaviour. It aims to: define social search; present a taxonomy of social search; and propose a user-centred social search method. Design/methodology/approach: A mixed method approach was adopted to investigate…

  11. Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome.

    Directory of Open Access Journals (Sweden)

    Md Mahiuddin Ahmed

    Full Text Available Down syndrome (DS is caused by an extra copy of human chromosome 21 (Hsa21. Although it is the most common genetic cause of intellectual disability (ID, there are, as yet, no effective pharmacotherapies. The Ts65Dn mouse model of DS is trisomic for orthologs of ∼55% of Hsa21 classical protein coding genes. These mice display many features relevant to those seen in DS, including deficits in learning and memory (L/M tasks requiring a functional hippocampus. Recently, the N-methyl-D-aspartate (NMDA receptor antagonist, memantine, was shown to rescue performance of the Ts65Dn in several L/M tasks. These studies, however, have not been accompanied by molecular analyses. In previous work, we described changes in protein expression induced in hippocampus and cortex in control mice after exposure to context fear conditioning (CFC, with and without memantine treatment. Here, we extend this analysis to Ts65Dn mice, measuring levels of 85 proteins/protein modifications, including components of MAP kinase and MTOR pathways, and subunits of NMDA receptors, in cortex and hippocampus of Ts65Dn mice after failed learning in CFC and after learning was rescued by memantine. We show that, compared with wild type littermate controls, (i of the dynamic responses seen in control mice in normal learning, >40% also occur in Ts65Dn in failed learning or are compensated by baseline abnormalities, and thus are considered necessary but not sufficient for successful learning, and (ii treatment with memantine does not in general normalize the initial protein levels but instead induces direct and indirect responses in approximately half the proteins measured and results in normalization of the endpoint protein levels. Together, these datasets provide a first view of the complexities associated with pharmacological rescue of learning in the Ts65Dn. Extending such studies to additional drugs and mouse models of DS will aid in identifying pharmacotherapies for effective

  12. Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice.

    Science.gov (United States)

    Leroy, Karelle; Ando, Kunie; Laporte, Vincent; Dedecker, Robert; Suain, Valérie; Authelet, Michèle; Héraud, Céline; Pierrot, Nathalie; Yilmaz, Zehra; Octave, Jean-Noël; Brion, Jean-Pierre

    2012-12-01

    Lack of tau expression has been reported to protect against excitotoxicity and to prevent memory deficits in mice expressing mutant amyloid precursor protein (APP) identified in familial Alzheimer disease. In APP mice, mutant presenilin 1 (PS1) enhances generation of Aβ42 and inhibits cell survival pathways. It is unknown whether the deficient phenotype induced by concomitant expression of mutant PS1 is rescued by absence of tau. In this study, we have analyzed the effect of tau deletion in mice expressing mutant APP and PS1. Although APP/PS1/tau(+/+) mice had a reduced survival, developed spatial memory deficits at 6 months and motor impairments at 12 months, these deficits were rescued in APP/PS1/tau(-/-) mice. Neuronal loss and synaptic loss in APP/PS1/tau(+/+) mice were rescued in the APP/PS1/tau(-/-) mice. The amyloid plaque burden was decreased by roughly 50% in the cortex and the spinal cord of the APP/PS1/tau(-/-) mice. The levels of soluble and insoluble Aβ40 and Aβ42, and the Aβ42/Aβ40 ratio were reduced in APP/PS1/tau(-/-) mice. Levels of phosphorylated APP, of β-C-terminal fragments (CTFs), and of β-secretase 1 (BACE1) were also reduced, suggesting that β-secretase cleavage of APP was reduced in APP/PS1/tau(-/-) mice. Our results indicate that tau deletion had a protective effect against amyloid induced toxicity even in the presence of mutant PS1 and reduced the production of Aβ. Copyright © 2012 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  13. Functional phenotypic rescue of Caenorhabditis elegans neuroligin-deficient mutants by the human and rat NLGN1 genes.

    Directory of Open Access Journals (Sweden)

    Fernando Calahorro

    Full Text Available Neuroligins are cell adhesion proteins that interact with neurexins at the synapse. This interaction may contribute to differentiation, plasticity and specificity of synapses. In humans, single mutations in neuroligin encoding genes lead to autism spectrum disorder and/or mental retardation. Caenorhabditis elegans mutants deficient in nlg-1, an orthologue of human neuroligin genes, have defects in different behaviors. Here we show that the expression of human NLGN1 or rat Nlgn1 cDNAs in C. elegans nlg-1 mutants rescues the fructose osmotic strength avoidance and gentle touch response phenotypes. Two specific point mutations in NLGN3 and NLGN4 genes, involved in autistic spectrum disorder, were further characterized in this experimental system. The R451C allele described in NLGN3, was analyzed with both human NLGN1 (R453C and worm NLG-1 (R437C proteins, and both were not functional in rescuing the osmotic avoidance behavior and the gentle touch response phenotype. The D396X allele described in NLGN4, which produces a truncated protein, was studied with human NLGN1 (D432X and they did not rescue any of the behavioral phenotypes analyzed. In addition, RNAi feeding experiments measuring gentle touch response in wild type strain and worms expressing SID-1 in neurons (which increases the response to dsRNA, both fed with bacteria expressing dsRNA for nlg-1, provided evidence for a postsynaptic in vivo function of neuroligins both in muscle cells and neurons, equivalent to that proposed in mammals. This finding was further confirmed generating transgenic nlg-1 deficient mutants expressing NLG-1 under pan-neuronal (nrx-1 or pan-muscular (myo-3 specific promoters. All these results suggest that the nematode could be used as an in vivo model for studying particular synaptic mechanisms with proteins orthologues of humans involved in pervasive developmental disorders.

  14. [Reliability and validity of assessment of educational outcomes obtained by students of Medical Rescue at Medical University of Warsaw].

    Science.gov (United States)

    Panczyk, Mariusz; Stachacz, Grzegorz; Gałązkowski, Robert; Gotlib, Joanna

    2016-01-01

    In the interest of preservation of high degree of objectivity of information about students' educational outcomes, a system of assessment needs to meet criteria of appropriate reliability and validity. Analysis of reliability and validity of the system of assessment of students' educational outcomes for courses followed by an examination and covered by a curriculum in Medical Rescue at Medical University of Warsaw (MU W). A retrospective study enrolling a group of 421 students of eight subsequent full education cycles. Detailed data concerning grades for fourteen courses followed by an examination in the entire course of studies were collected. Reliability (Cronbach's alpha coefficient) and criteria validity (Spearman's rank correlation) were assessed. Internal consistency was estimated using a multiple regression model. The levels of assessment reliability for the general university, pre-clinical, and clinical scopes amounted to alpha: 0.42, 0.53, and 0.70, respectively. The strongest positive correlations between the results of pre-clinical and clinical trainings were found for the Anatomy course (r ≈ 0.30). Only in the case of the Pharmacology course it was found that students' achievements in this field were significantly correlated with all other courses of clinical training. The influence of educational outcomes in particular areas of clinical training on the final grade for the entire course of studies was diverse (β regression between 0.04 and 0.11). While the Pharmacology course had the strongest impact on final results, the Surgery course had the least influence on students' final grades (β = 0.04). 1. Sufficient reliability of the system of assessment of educational outcomes in Medical Rescue showed good precision and repeatability of assessment. 2. A low level of validity was caused by a failure to keep the appropriateness of the assessment of educational outcomes in several clinical courses. 3. Prognostic and diagnostic validity of methods used for

  15. GIS Support for Flood Rescue

    DEFF Research Database (Denmark)

    Liang, Gengsheng; Mioc, Darka; Anton, François

    2007-01-01

    Under flood events, the ground traffic is blocked in and around the flooded area due to damages to roads and bridges. The traditional transportation network may not always help people to make a right decision for evacuation. In order to provide dynamic road information needed for flood rescue, we...... to retrieve the shortest and safest route in Fredericton road network during flood event. It enables users to make a timely decision for flood rescue. We are using Oracle Spatial to deal with emergency situations that can be applied to other constrained network applications as well....... developed an adaptive web-based transportation network application using Oracle technology. Moreover, the geographic relationships between the road network and flood areas are taken into account. The overlay between the road network and flood polygons is computed on the fly. This application allows users...

  16. High Dose Cyclophosphamide without Stem Cell Rescue in 207 Patients with Aplastic anemia and other Autoimmune Diseases

    Science.gov (United States)

    DeZern, Amy E.; Petri, Michelle; Drachman, Daniel B.; Kerr, Doug; Hammond, Edward R.; Kowalski, Jeanne; Tsai, Hua-Ling; Loeb, David M.; Anhalt, Grant; Wigley, Fredrick; Jones, Richard J.; Brodsky, Robert A.

    2011-01-01

    High-dose cyclophosphamide has long been used an anticancer agent, a conditioning regimen for hematopoietic stem cell transplantation and as potent immunosuppressive agent in autoimmune diseases including aplastic anemia. High-dose cyclophosphamide is highly toxic to lymphocytes but spares hematopoietic stem cells because of their abundant levels of aldehyde dehydrogenase, the major mechanism of cyclophosphamide inactivation. High dose cyclophosphamide therapy induces durable remissions in most patients with acquired aplastic anemia. Moreover, high-dose cyclophosphamide without hematopoietic stem cell rescue has shown activity in a variety of other severe autoimmune diseases. Here we review the history of cyclophosphamide as is applies to aplastic anemia (AA) and other autoimmune diseases. Included here are the historical data from early patients treated for AA as well as an observational retrospective study in a single tertiary care hospital. This latter component was designed to assess the safety and efficacy of high-dose cyclophosphamide therapy without stem cell rescue in patients with refractory autoimmune diseases. We analyzed fully the 140 patients with severe, progressive autoimmune diseases treated. All patients discussed here received cyclophosphamide, 50 mg/kg per day for 4 consecutive days. Response, relapse and overall survival were measured. Response was defined as a decrease in disease activity in conjunction with a decrease or elimination of immune modulating drugs. Relapse was defined as worsening disease activity and/or a requirement of an increase in dose of, or administration of new, immunosuppressive medications. Hematologic recovery occurred in all patients. The overall response rate of the was 95%, and 44% of those patients remain progression-free with a median follow up time of 36 (range 1–120) months for the 140 patients analyzed together. The overall actuarial and event free survival across all diseases at 60 months is 90.7% and 20

  17. Morphological and functional rescue in RCS rats after RPE cell line transplantation at a later stage of degeneration.

    Science.gov (United States)

    Wang, Shaomei; Lu, Bin; Girman, Sergej; Holmes, Toby; Bischoff, Nicolas; Lund, Raymond D

    2008-01-01

    It is well documented that grafting of cells in the subretinal space of Royal College of Surgeons (RCS) rats limits deterioration of vision and loss of photoreceptors if performed early in postnatal life. What is unclear is whether cells introduced later, when photoreceptor degeneration is already advanced, can still be effective. This possibility was examined in the present study, using the human retinal pigment epithelial cell line, ARPE-19. Dystrophic RCS rats (postnatal day [P] 60) received subretinal injection of ARPE-19 cells (2 x 10(5)/3 microL/eye). Spatial frequency was measured by recording optomotor responses at P100 and P150, and luminance threshold responses were recorded from the superior colliculus at P150. Retinas were stained with cresyl violet, retinal cell-specific markers, and a human nuclear marker. Control animals were injected with medium alone. Animals comparably treated with grafts at P21 were available for comparison. All animals were treated with immunosuppression. Later grafts preserved both spatial frequency and threshold responses over the control and delayed photoreceptor degeneration. There were two to three layers of rescued photoreceptors even at P150, compared with a scattered single layer in sham and untreated control retinas. Retinal cell marker staining showed an orderly array of the inner retinal lamination. The morphology of the second-order neurons was better preserved around the grafted area than in regions distant from graft. Sham injection had little effect in rescuing the photoreceptors. RPE cell line transplants delivered later in the course of degeneration can preserve not only the photoreceptors and inner retinal lamination but also visual function in RCS rats. However, early intervention can achieve better rescue.

  18. Organizational Search Strategy: An Examination of Interdependencies, Locus and Temporality of Search

    NARCIS (Netherlands)

    Ebrahim, Mahdi

    2017-01-01

    Notwithstanding the ample research on organizational search and its performance implications, the factors that shape the organizations’ search strategy is fairly under-explored. This study investigates how problems’ characteristics influence the managerial decision of searching jointly or

  19. A critical review of the Mediterranean sea turtle rescue network: a web looking for a weaver

    Directory of Open Access Journals (Sweden)

    Judith Ullmann

    2015-06-01

    Full Text Available A key issue in conservation biology is recognizing and bridging the gap between scientific results and specific action. We examine sea turtles—charismatic yet endangered flagship species—in the Mediterranean, a sea with historically high levels of exploitation and 22 coastal nations. We take sea turtle rescue facilities as a visible measure for implemented conservation action. Our study yielded 34 confirmed sea turtle rescue centers, 8 first-aid stations, and 7 informal rescue institutions currently in operation. Juxtaposing these facilities to known sea turtle distribution and threat hotspots reveals a clear disconnect. Only 14 of the 22 coastal countries had centers, with clear gaps in the Middle East and Africa. Moreover, the information flow between centers is apparently limited. The populations of the two species nesting in the Mediterranean, the loggerhead Caretta caretta and the green turtle Chelonia mydas, are far below historical levels and face a range of anthropogenic threats at sea and on land. Sea turtle rescue centers are acknowledged to reduce mortality in bycatch hotspots, provide a wealth of scientific data, and raise public awareness. The proposal for a Mediterranean-wide rescue network as published by the Regional Activity Centre for Specially Protected Areas a decade ago has not materialized in its envisioned scope. We discuss the efficiency, gaps, and needs for a rescue network and call for establishing additional rescue centers and an accompanying common online database to connect existing centers. This would provide better information on the number and types of rescue facilities on a Mediterranean scale, improve communication between these facilities, enhance standardization of procedures, yield large-scale data on the number of treated turtles and their injuries, and thus provide valuable input for targeted conservation measures.

  20. Database Search Engines: Paradigms, Challenges and Solutions.

    Science.gov (United States)

    Verheggen, Kenneth; Martens, Lennart; Berven, Frode S; Barsnes, Harald; Vaudel, Marc

    2016-01-01

    The first step in identifying proteins from mass spectrometry based shotgun proteomics data is to infer peptides from tandem mass spectra, a task generally achieved using database search engines. In this chapter, the basic principles of database search engines are introduced with a focus on open source software, and the use of database search engines is demonstrated using the freely available SearchGUI interface. This chapter also discusses how to tackle general issues related to sequence database searching and shows how to minimize their impact.

  1. Deep brain stimulation, histone deacetylase inhibitors and glutamatergic drugs rescue resistance to fear extinction in a genetic mouse model

    Science.gov (United States)

    Whittle, Nigel; Schmuckermair, Claudia; Gunduz Cinar, Ozge; Hauschild, Markus; Ferraguti, Francesco; Holmes, Andrew; Singewald, Nicolas

    2013-01-01

    Anxiety disorders are characterized by persistent, excessive fear. Therapeutic interventions that reverse deficits in fear extinction represent a tractable approach to treating these disorders. We previously reported that 129S1/SvImJ (S1) mice show no extinction learning following normal fear conditioning. We now demonstrate that weak fear conditioning does permit fear reduction during massed extinction training in S1 mice, but reveals specific deficiency in extinction memory consolidation/retrieval. Rescue of this impaired extinction consolidation/retrieval was achieved with d-cycloserine (N-methly-d-aspartate partial agonist) or MS-275 (histone deacetylase (HDAC) inhibitor), applied after extinction training. We next examined the ability of different drugs and non-pharmacological manipulations to rescue the extreme fear extinction deficit in S1 following normal fear conditioning with the ultimate aim to produce low fear levels in extinction retrieval tests. Results showed that deep brain stimulation (DBS) by applying high frequency stimulation to the nucleus accumbens (ventral striatum) during extinction training, indeed significantly reduced fear during extinction retrieval compared to sham stimulation controls. Rescue of both impaired extinction acquisition and deficient extinction consolidation/retrieval was achieved with prior extinction training administration of valproic acid (a GABAergic enhancer and HDAC inhibitor) or AMN082 [metabotropic glutamate receptor 7 (mGlu7) agonist], while MS-275 or PEPA (AMPA receptor potentiator) failed to affect extinction acquisition in S1 mice. Collectively, these data identify potential beneficial effects of DBS and various drug treatments, including those with HDAC inhibiting or mGlu7 agonism properties, as adjuncts to overcome treatment resistance in exposure-based therapies. This article is part of a Special Issue entitled ‘Cognitive Enhancers’. PMID:22722028

  2. Fatty Acid Oxidation and Calcium Homeostasis are Involved in the Rescue of Bupivacaine Induced Cardiotoxicity by Lipid Emulsion in Rats

    Science.gov (United States)

    Partownavid, Parisa; Umar, Soban; Li, Jingyuan; Rahman, Siamak; Eghbali, Mansoureh

    2012-01-01

    OBJECTIVES Lipid Emulsion (LE) has been shown to be effective in resuscitating bupivacaine-induced cardiac arrest but its mechanism of action is not clear. Here we investigated whether fatty acid oxidation is required for rescue of bupivacaine induced cardiotoxicity by LE in rats. We also compared the mitochondrial function and calcium threshold for triggering of mitochondrial permeability transition pore (mPTP) opening in bupivacaine-induced cardiac arrest before and after resuscitation with LE. DESIGN Prospective, randomized, animal study. SETTING University Research Laboratory. SUBJECTS Adult male Sprague-Dawley rats. INTERVENTIONS Asystole was achieved with a single dose of bupivacaine (10mg/kg over 20seconds, i.v.) and 20% LE infusion (5ml/kg bolus, and 0.5ml/kg/min maintenance) with cardiac massage started immediately. The rats in CVT group were pretreated with a single dose of fatty acid oxidation inhibitor CVT (0.5, 0.25, 0.125 or 0.0625mg/kg bolus i.v.) 5min prior to inducing asystole by bupivacaine overdose. Heart rate (HR), ejection fraction (EF), fractional shortening (FS), the threshold for opening of mPTP, oxygen consumption and membrane potential were measured. The values are Mean±SEM. MEASUREMENTS AND MAIN RESULTS Administration of bupivacaine resulted in asystole. ILP infusion improved the cardiac function gradually as the EF was fully recovered within 5min (EF=64±4% and FS=36±3%, n=6) and heart rate increased to 239±9 beats/min (71% recovery, n=6) within 10min. LE was only able to rescue rats pretreated with low dose of CVT (0.0625mg/kg) (HR=~181±11 beats/min at 10 min, recovery of 56%; EF=50±1%; FS=26±0.6% at 5min, n=3) but was unable to resuscitate rats pretreated with higher doses of CVT (0.5, 0.25 or 0.125mg/kg). The calcium retention capacity in response to Ca2+ overload was significantly higher in cardiac mitochondria isolated from rats resuscitated with 20% LE compared to the group that did not receive ILP after bupivacaine

  3. Neurological disease mutations of α3 Na+,K+-ATPase: Structural and functional perspectives and rescue of compromised function.

    Science.gov (United States)

    Holm, Rikke; Toustrup-Jensen, Mads S; Einholm, Anja P; Schack, Vivien R; Andersen, Jens P; Vilsen, Bente

    2016-11-01

    Na + ,K + -ATPase creates transmembrane ion gradients crucial to the function of the central nervous system. The α-subunit of Na + ,K + -ATPase exists as four isoforms (α1-α4). Several neurological phenotypes derive from α3 mutations. The effects of some of these mutations on Na + ,K + -ATPase function have been studied in vitro. Here we discuss the α3 disease mutations as well as information derived from studies of corresponding mutations of α1 in the light of the high-resolution crystal structures of the Na + ,K + -ATPase. A high proportion of the α3 disease mutations occur in the transmembrane sector and nearby regions essential to Na + and K + binding. In several cases the compromised function can be traced to disturbance of the Na + specific binding site III. Recently, a secondary mutation was found to rescue the defective Na + binding caused by a disease mutation. A perspective is that it may be possible to develop an efficient pharmaceutical mimicking the rescuing effect. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. RecA: Regulation and Mechanism of a Molecular Search Engine.

    Science.gov (United States)

    Bell, Jason C; Kowalczykowski, Stephen C

    2016-06-01

    Homologous recombination maintains genomic integrity by repairing broken chromosomes. The broken chromosome is partially resected to produce single-stranded DNA (ssDNA) that is used to search for homologous double-stranded DNA (dsDNA). This homology driven 'search and rescue' is catalyzed by a class of DNA strand exchange proteins that are defined in relation to Escherichia coli RecA, which forms a filament on ssDNA. Here, we review the regulation of RecA filament assembly and the mechanism by which RecA quickly and efficiently searches for and identifies a unique homologous sequence among a vast excess of heterologous DNA. Given that RecA is the prototypic DNA strand exchange protein, its behavior affords insight into the actions of eukaryotic RAD51 orthologs and their regulators, BRCA2 and other tumor suppressors. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. Dispatching Plan Based on Route Optimization Model Considering Random Wind for Aviation Emergency Rescue

    Directory of Open Access Journals (Sweden)

    Ming Zhang

    2016-01-01

    Full Text Available Aviation emergency rescue is an effective means of nature disaster relief that is widely used in many countries. The dispatching plan of aviation emergency rescue guarantees the efficient implementation of this relief measure. The conventional dispatching plan that does not consider random wind factors leads to a nonprecise quick-responsive scheme and serious safety issues. In this study, an aviation emergency rescue framework that considers the influence of random wind at flight trajectory is proposed. In this framework, the predicted wind information for a disaster area is updated by using unscented Kalman filtering technology. Then, considering the practical scheduling problem of aircraft emergency rescue at present, a multiobjective model is established in this study. An optimization model aimed at maximizing the relief supply satisfaction, rescue priority satisfaction, and minimizing total rescue flight distance is formulated. Finally, the transport times of aircraft with and without the influence of random wind are analyzed on the basis of the data of an earthquake disaster area. Results show that the proposed dispatching plan that considers the constraints of updated wind speed and direction is highly applicable in real operations.

  6. Responses to Environmental & Societal Challenges for our Unstable Earth (RESCUE) foresight initiative - towards a European response to grand challenges in sustainability research and learning

    Science.gov (United States)

    Avril, B.; et al.

    2012-04-01

    The "Responses to Environmental and Societal Challenges for our Unstable Earth" (RESCUE; www.esf.org/rescue) foresight initiative - a joint COST-ESF "Frontiers of Science" initiative - aimed to help Europe address the societal and scientific challenges related to global environmental change and the related resilience issues. In RESCUE, the focus of attention was on people and the goal was to stimulate an integrated, innovative response from natural, social and human sciences. The RESCUE foresight initiative began in September 2009 and has recently been completed. RESCUE had the following key objectives: 1. To propose a strategic process for natural, social and human sciences to improve their ability and capacity to work together to address global environmental change through interdisciplinary synergy and to respond effectively to societal and policy-relevant needs; 2. To articulate new scientific issues related to global environmental change and the related resilience issues, especially those of transdisciplinary nature and of major relevance to society; 3. To explore new approaches towards truly integrated, interdisciplinary science, and to facilitate the 'revolution' in education and capacity building it requires. The work of RESCUE focused on the following themes: · Contributions from social sciences and humanities in developing responses to challenges of the Anthropocene; · Collaboration between the natural, social and human sciences in global environmental change and resilience studies; · Requirements for research methodologies and data; · Education and capacity building - towards a 'revolution'; · The interface between science and policy, communication and outreach. The RESCUE recommendations include the following issues to be addressed by science-funders, science policy-makers, researchers, practitioners, educators and a range of other societal actors: · develop an institutional framework for an open knowledge society, · re-organise research so

  7. Melatonin rescues cardiovascular dysfunction during hypoxic development in the chick embryo.

    Science.gov (United States)

    Itani, Nozomi; Skeffington, Katie L; Beck, Christian; Niu, Youguo; Giussani, Dino A

    2016-01-01

    There is a search for rescue therapy against fetal origins of cardiovascular disease in pregnancy complicated by chronic fetal hypoxia, particularly following clinical diagnosis of fetal growth restriction (FGR). Melatonin protects the placenta in adverse pregnancy; however, whether melatonin protects the fetal heart and vasculature in hypoxic pregnancy independent of effects on the placenta is unknown. Whether melatonin can rescue fetal cardiovascular dysfunction when treatment commences following FGR diagnosis is also unknown. We isolated the effects of melatonin on the developing cardiovascular system of the chick embryo during hypoxic incubation. We tested the hypothesis that melatonin directly protects the fetal cardiovascular system in adverse development and that it can rescue dysfunction following FGR diagnosis. Chick embryos were incubated under normoxia or hypoxia (14% O2) from day 1 ± melatonin treatment (1 mg/kg/day) from day 13 of incubation (term ~21 days). Melatonin in hypoxic chick embryos rescued cardiac systolic dysfunction, impaired cardiac contractility and relaxability, increased cardiac sympathetic dominance, and endothelial dysfunction in peripheral circulations. The mechanisms involved included reduced oxidative stress, enhanced antioxidant capacity and restored vascular endothelial growth factor expression, and NO bioavailability. Melatonin treatment of the chick embryo starting at day 13 of incubation, equivalent to ca. 25 wk of gestation in human pregnancy, rescues early origins of cardiovascular dysfunction during hypoxic development. Melatonin may be a suitable antioxidant candidate for translation to human therapy to protect the fetal cardiovascular system in adverse pregnancy. © 2015 The Authors. Journal of Pineal Research. Published by John Wiley & Sons Ltd.

  8. Department of Defense Dictionary of Military and Associated Terms

    Science.gov (United States)

    2008-05-30

    friendly air, land, and naval operations. See also immediate nuclear support; preplanned nuclear support. nuclear transmutation — Artificially...petroleum office SAPR sexual assault prevention and response SAR satellite access request; search and rescue; special access requirement; suspicious...activity report; synthetic aperture radar As Amended Through 30 May 2008 Abbreviations and Acronyms JP 1-02 A-129 SARC sexual assault

  9. A Novel Design of Rescue Capsule considering the Pressure Characteristics and Thermal Dynamic Response with Thermomechanical Coupling Action Subjected to Gas Explosion Load

    Directory of Open Access Journals (Sweden)

    Xiaowei Zhai

    2017-01-01

    Full Text Available To ensure the structural safety and reliability of coal mine rescue capsule in disastrous surroundings after gas explosion, in this paper, the thermomechanical coupling effect on a certain structure subjected to gas explosion was analyzed, and then a novel rescue capsule with a combination of radius and square features was designed according to the underground surroundings and relevant regulations on mine rescue devices. Foremost, the coupling mechanism of thermal-fluid-solid interaction between gas explosion shock wave and rescue capsule and the thermal dynamic response of the capsule subjected to explosion load of gas/air mixture was investigated and revealed by employing LS-DYNA. The variation laws and characteristics of stress field, displacement field, and temperature field of the capsule were analyzed based on the simulation results. Results show that the structural safety, tightness, and reliability of the capsule meet the requirements of the national safety regulations. The design method presented in this work provides a new thought for design of coal mine rescue capsule.

  10. The League of Nations' rescue of Armenian genocide survivors and the making of modern humanitarianism, 1920-1927.

    Science.gov (United States)

    Watenpaugh, Keith David

    2010-01-01

    The essay centers of the efforts by the League of Nations to rescue women and children survivors of the 1915 Armenian Genocide. This rescue -- a seemingly unambiguous good -- was at once a constitutive act in drawing the boundaries of the international community, a key moment in the definition of humanitarianism, and a site of resistance to the colonial presence in the post-Ottoman Eastern Mediterranean. Drawing from a wide range of source materials in a number of languages, including Turkish, Armenian, and Arabic, the essay brings the intellectual and social context of humanitarianism in initiating societies together with the lived experience of humanitarianism in the places where the act took form. In so doing, it draws our attention to the proper place of the Eastern mediterranean, and its women and children, in the global history of humanitarianism. The prevailing narrative of the history of human rights places much of its emphasis on the post-World War II era, the international reaction to the Holocaust, and the founding of the United Nations. yet contemporary human rights thinking also took place within practices of humanitarianism in the interwar period, and is necessarily inseparable from the histories of refugees, colonialism, and the non-West.

  11. The axon-protective WLD(S) protein partially rescues mitochondrial respiration and glycolysis after axonal injury.

    Science.gov (United States)

    Godzik, Katharina; Coleman, Michael P

    2015-04-01

    The axon-protective Wallerian degeneration slow (WLD(S)) protein can ameliorate the decline in axonal ATP levels after neurite transection. Here, we tested the hypothesis that this effect is associated with maintenance of mitochondrial respiration and/or glycolysis. We used isolated neurites of superior cervical ganglion (SCG) cultures in the Seahorse XF-24 Metabolic Flux Analyser to determine mitochondrial respiration and glycolysis under different conditions. We observed that both mitochondrial respiration and glycolysis declined significantly during the latent phase of Wallerian degeneration. WLD(S) partially reduced the decline both in glycolysis and in mitochondrial respiration. In addition, we found that depleting NAD levels in uncut cultures led to changes in mitochondrial respiration and glycolysis similar to those rescued by WLD(S) after cut, suggesting that the maintenance of NAD levels in Wld(S) neurites after axonal injury at least partially underlies the maintenance of ATP levels. However, by using another axon-protective mutation (Sarm1(-/-)), we could demonstrate that rescue of basal ECAR (and hence probably glycolysis) rather than basal OCR (mitochondrial respiration) may be part of the protective phenotype to delay Wallerian degeneration. These findings open new routes to study glycolysis and the connection between NAD and ATP levels in axon degeneration, which may help to eventually develop therapeutic strategies to treat neurodegenerative diseases.

  12. Characteristics of relinquishing and adoptive owners of horses associated with U.S. nonprofit equine rescue organizations.

    Science.gov (United States)

    Holcomb, Kathryn E; Stull, Carolyn L; Kass, Philip H

    2012-01-01

    Nonprofit equine rescue organizations in the United States provide care for relinquished horses and may offer adoption programs. With an estimated 100,000 "unwanted" horses per year and few municipal shelters providing wholesale euthanasia, there is a need to minimize the number of unwanted horses and maximize their successful transition to new caregivers. This study's objectives were to characterize the relinquishing and adoptive owners interacting with nonprofit rescue organizations. Nonprofit organizations (n = 144) in 37 states provided information by survey on 280 horses relinquished between 2006 and 2009, from which 73 were adopted. Results show the majority of relinquishing owners were women, whereas adoptive owners were primarily families or couples. Most relinquishing owners had previous equine experience and had owned the horse for 1 to 5 years; about half owned 1 other horse. Three quarters of the adoptive owners possessed additional horses housed on their property. The primary use for rehomed horses was for riding or driving. These findings will serve to help develop effective education programs for responsible horse ownership and optimize acceptance criteria and successful adoption strategies of horses by nonprofit organizations.

  13. Measurment and Reporting of Comprehensive Income: Search ...

    African Journals Online (AJOL)

    Measurment and Reporting of Comprehensive Income: Search, Challenges, ... of periods of stable and unstable economic situation and satisfies varied users' ... Keywords: Historical accounting; comprehensive income; asset valuation model.

  14. OBOSNOVANIYe RAZRABOTKI MOBIL'NOGO MNOGOFUNKTSIONAL'NOGO GORNOSPASATEL'NOGO KOMPLEKSA S ELEMENTAMI ROBOTIZATSII DLYA LIKVIDATSII POSLEDSTVIY AVARIY V GORNYKH VYRABOTKAKH SHAKHT I RUDNIKOV [RATIONALE FOR THE DEVELOPMENT OF A MOBILE MULTIFUNCTIONAL MINE RESCUE COMPLEX, WITH ELEMENTS OF ROBOTICS, FOR THE ELIMINATION OF THE CONSEQUENCES OF ACCIDENTS IN MINE WORKINGS

    Directory of Open Access Journals (Sweden)

    Yarosh A.S.

    2017-09-01

    Full Text Available The article provides an overview of accidents in the Kuzbass mines in the last 16 years related to the collapse of the rubble and excavations. A modern state of the performance of rescue operations in case of caving and blockages is described. Scientific research in the field of mine rescue work, in particular the availability of effective means of mechanization to eliminate blockages in overseas coal mines, has not given positive results, except for information that in this case, the light, portable machines with manual drive. The concept of creating a mobile multifunctional equipment (device for mechanization of disassembly and elimination of blockages is outlined. The requirements for the creation of mobile multifunctional equipment are formulated. A device (mine-rescue complex is proposed, which can be the basis for the development of new means of mechanization of mine rescue work in the event of the elimination of debris. It is noted that the creation of the complex will allow: to shorten the time for the search and release of people from the dam, to provide them with the first medical aid and to ensure people's escape from the obstruction; ensure the safety of mine rescue work and the safety of life and health of mine rescuers; reduce or completely eliminate heavy manual labor; in a short time to eliminate blockages and caving in order to restore the life support of the enterprise; increase the prestige of the profession of a mine rescuer, - reduce social tension in emergency situations. The name of the new development "Creation of a mobile multifunctional mine rescue complex with robotic elements (MMGSK" is defined. An opinion on a possible performer on the creation of this innovative work is presented.

  15. Operator theory, operator algebras and applications

    CERN Document Server

    Lebre, Amarino; Samko, Stefan; Spitkovsky, Ilya

    2014-01-01

    This book consists of research papers that cover the scientific areas of the International Workshop on Operator Theory, Operator Algebras and Applications, held in Lisbon in September 2012. The volume particularly focuses on (i) operator theory and harmonic analysis (singular integral operators with shifts; pseudodifferential operators, factorization of almost periodic matrix functions; inequalities; Cauchy type integrals; maximal and singular operators on generalized Orlicz-Morrey spaces; the Riesz potential operator; modification of Hadamard fractional integro-differentiation), (ii) operator algebras (invertibility in groupoid C*-algebras; inner endomorphisms of some semi group, crossed products; C*-algebras generated by mappings which have finite orbits; Folner sequences in operator algebras; arithmetic aspect of C*_r SL(2); C*-algebras of singular integral operators; algebras of operator sequences) and (iii) mathematical physics (operator approach to diffraction from polygonal-conical screens; Poisson geo...

  16. BACE1 inhibition by microdose lithium formulation NP03 rescues memory loss and early stage amyloid neuropathology.

    Science.gov (United States)

    Wilson, E N; Do Carmo, S; Iulita, M F; Hall, H; Ducatenzeiler, A; Marks, A R; Allard, S; Jia, D T; Windheim, J; Cuello, A C

    2017-08-01

    Lithium is first-line therapy for bipolar affective disorder and has recently been shown to have protective effects in populations at risk for Alzheimer's disease (AD). However, the mechanism underlying this protection is poorly understood and consequently limits its possible therapeutic application in AD. Moreover, conventional lithium formulations have a narrow therapeutic window and are associated with a severe side effect profile. Here we evaluated a novel microdose formulation of lithium, coded NP03, in a well-characterized rat model of progressive AD-like amyloid pathology. This formulation allows microdose lithium delivery to the brain in the absence of negative side effects. We found that NP03 rescued key initiating components of AD pathology, including inactivating GSK-3β, reducing BACE1 expression and activity, and reducing amyloid levels. Notably, NP03 rescued memory loss, impaired CRTC1 promoter binding of synaptic plasticity genes and hippocampal neurogenesis. These results raise the possibility that NP03 be of therapeutic value in the early or preclinical stages of AD.

  17. Keep Searching and You’ll Find

    DEFF Research Database (Denmark)

    Laursen, Keld

    2012-01-01

    This article critically reviews and synthesizes the contributions found in theoretical and empirical studies of firm-level innovation search processes. It explores the advantages and disadvantages of local and non-local search, discusses organizational responses, and identifies potential exogenous...... different search strategies, but end up with very similar technological profiles in fast-growing technologies. The article concludes by highlighting what we have learnt from the literature and suggesting some new avenues for research....

  18. Comparing performance and situation awareness in USAR unit tasks in a virtual and real environment

    NARCIS (Netherlands)

    Horsch, C.H.G.; Smets, N.J.J.M.; Neerincx, M.A.; Cuijpers, R.H.

    2013-01-01

    A convenient way to test Urban Search And Rescue (USAR) robots would be in virtual environments (VEs). Evaluations in VEs are generally accepted as alternative for real scenarios. There are obvious differences between operation in a real and virtual environment. Nonetheless, the current experiment

  19. Autonomous search

    CERN Document Server

    Hamadi, Youssef; Saubion, Frédéric

    2012-01-01

    Autonomous combinatorial search (AS) represents a new field in combinatorial problem solving. Its major standpoint and originality is that it considers that problem solvers must be capable of self-improvement operations. This is the first book dedicated to AS.

  20. Axions-motivation, limits and searches

    International Nuclear Information System (INIS)

    Raffelt, G G

    2007-01-01

    The axion solution of the strong CP problem provides a number of possible windows to physics beyond the standard model, notably in the form of searches for solar axions and for galactic axion dark matter, but in a broader context also inspires searches for axion-like particles in pure laboratory experiments. We briefly review the motivation for axions, astrophysical limits, their possible cosmological role, and current searches for axions and axion-like particles

  1. BSM searches (SUSY and Exotic) from ATLAS

    CERN Document Server

    ATLAS Collaboration; The ATLAS collaboration

    2015-01-01

    Searches for new physics beyond the Standard Model (SM) at the LHC are mainly driven by two approaches: a signature-based search where one looks for a deviation from the SM prediction in event yield or kinematic properties, and a more theory-oriented approach where the search is designed to look for specific signatures/topologies predicted by certain beyond standard model (BSM ) scenarios. Typical examples for the latter are searches for Supersymmetry and other BSM theories with extended symmetries. Supersymmetry predicts a new partner for every SM particle. An extension to the SM by introducing new gauge or global symmetries (including in Hidden Sector) usually leads to the presence of new heavy gauge bosons. Extensive searches for such particles have been performed in ATLAS at LHC in the context of Supersymmetry, Extended Gauge models, Technicolor, Little Higgs, Extra Dimensions, Left-Right symmetric models, and many other BSM scenarios. Highlights from these searches are presented.

  2. 30 CFR 49.7 - Physical requirements for mine rescue team.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Physical requirements for mine rescue team. 49... EDUCATION AND TRAINING MINE RESCUE TEAMS § 49.7 Physical requirements for mine rescue team. (a) Each member of a mine rescue team shall be examined annually by a physician who shall certify that each person is...

  3. Social Work Literature Searching: Current Issues with Databases and Online Search Engines

    Science.gov (United States)

    McGinn, Tony; Taylor, Brian; McColgan, Mary; McQuilkan, Janice

    2016-01-01

    Objectives: To compare the performance of a range of search facilities; and to illustrate the execution of a comprehensive literature search for qualitative evidence in social work. Context: Developments in literature search methods and comparisons of search facilities help facilitate access to the best available evidence for social workers.…

  4. Erythropoietin Attenuates the Memory Deficits in Aging Rats by Rescuing the Oxidative Stress and Inflammation and Promoting BDNF Releasing.

    Science.gov (United States)

    Jia, Zhankui; Xue, Rui; Ma, Shengli; Xu, Jingjing; Guo, Si; Li, Songchao; Zhang, Erwei; Wang, Jun; Yang, Jinjian

    2016-10-01

    Aging is a natural process accompanied with many disorders, including the memory decline. The underlying mechanisms for the age-related memory decline are complicated. Previous work suggested that oxidative stress, inflammatory disturbance, and the neurotropic absence play important roles in the age-related disorders. Thus, to seek a drug to target those abnormalities might be a possible protective approach for aging. Here, we reported that supplements with exogenous erythropoietin (EPO) for 4 weeks could partially rescue the spatial and fear memory impairments in aged rats. The EPO treatment also suppresses the oxidative stress and inflammatory response. Most importantly, EPO supplement restores the mRNA and protein levels of brain-derived neurotrophic factor (BDNF), the critical neurotropic factor for synaptic plasticity and memory. Our study strongly suggests the potential usage of EPO in an anti-aging agent clinically.

  5. The topography of the environment alters the optimal search strategy for active particles

    Science.gov (United States)

    Volpe, Giorgio; Volpe, Giovanni

    2017-10-01

    In environments with scarce resources, adopting the right search strategy can make the difference between succeeding and failing, even between life and death. At different scales, this applies to molecular encounters in the cell cytoplasm, to animals looking for food or mates in natural landscapes, to rescuers during search and rescue operations in disaster zones, and to genetic computer algorithms exploring parameter spaces. When looking for sparse targets in a homogeneous environment, a combination of ballistic and diffusive steps is considered optimal; in particular, more ballistic Lévy flights with exponent α≤1 are generally believed to optimize the search process. However, most search spaces present complex topographies. What is the best search strategy in these more realistic scenarios? Here, we show that the topography of the environment significantly alters the optimal search strategy toward less ballistic and more Brownian strategies. We consider an active particle performing a blind cruise search for nonregenerating sparse targets in a 2D space with steps drawn from a Lévy distribution with the exponent varying from α=1 to α=2 (Brownian). We show that, when boundaries, barriers, and obstacles are present, the optimal search strategy depends on the topography of the environment, with α assuming intermediate values in the whole range under consideration. We interpret these findings using simple scaling arguments and discuss their robustness to varying searcher's size. Our results are relevant for search problems at different length scales from animal and human foraging to microswimmers' taxis to biochemical rates of reaction.

  6. Internet Job Search and Unemployment Durations

    OpenAIRE

    Kuhn, Peter; Skuterud, Mikal Skuterud

    2002-01-01

    After decades of stability, the technologies used by workers to locate new jobs began to change rapidly with the diffusion of internet access in the late 1990’s. Which types of persons incorporated the internet into their job search strategy, and did searching for work on line help these workers find new jobs faster? We address these questions using measures of internet job search derived from the December 1998 and August 2000 CPS Computer and Internet Supplements, matched with job search o...

  7. Arrow y Sen: el rescate del individuo y de las instituciones Arrow and Sen: rescuing the individual and institutions

    Directory of Open Access Journals (Sweden)

    Cante Freddy

    1998-12-01

    Full Text Available La teoría de la elección social que propone Arrow y Sen es una ruptura con los desarrollos hegemónicos de la microeconomía y de la macroeconomía en dos sentidos: rescata la diversidad de gustos y valores de cada individuo en oposición a los conceptos agregados; además, muestra que la conducta racional es quizás lo menos importante con lo que abre un diálogo con la economía institucional.The theory of social choice proposed by Arrow and Sen breaks with the hegemonic developments of microeconomics and macroeconomics in two senses: it rescues the diversity of tastes and values of each individual as opposed to aggregated concepts, and in addition it shows that rational behavior is perhaps the least important kind, which opens up a dialogue with institutional economics.

  8. The effects of savings on reservation wages and search effort

    NARCIS (Netherlands)

    Lammers, M.

    2014-01-01

    This paper discusses the interrelations among wealth, reservation wages and search effort. A theoretical job search model predicts wealth to affect reservation wages positively, and search effort negatively. Subsequently, reduced form equations for reservation wages and search intensity take these

  9. The Role of Army National Guard Special Forces Domestically And in Special Operations Command - North

    Science.gov (United States)

    2014-12-01

    Domestic Cannabis Suppression Operations Support ...................20 4. Counterdrug-Related Training and Training LEA/Military Personnel...domestic operations that the regular Army is prevented by Posse Comitatus1 restrictions, is a worthy topic for deeper exploration. This thesis...ones that include offensive measures taken to prevent , deter, preempt, and respond to terrorism. Hostage rescue, recovery of sensitive materials and

  10. Panoramic Search: The Interaction of Memory and Vision in Search through a Familiar Scene

    Science.gov (United States)

    Oliva, Aude; Wolfe, Jeremy M. Arsenio, Helga C.

    2004-01-01

    How do observers search through familiar scenes? A novel panoramic search method is used to study the interaction of memory and vision in natural search behavior. In panoramic search, observers see part of an unchanging scene larger than their current field of view. A target object can be visible, present in the display but hidden from view, or…

  11. Usability Testing of a Large, Multidisciplinary Library Database: Basic Search and Visual Search

    Directory of Open Access Journals (Sweden)

    Jody Condit Fagan

    2006-09-01

    Full Text Available Visual search interfaces have been shown by researchers to assist users with information search and retrieval. Recently, several major library vendors have added visual search interfaces or functions to their products. For public service librarians, perhaps the most critical area of interest is the extent to which visual search interfaces and text-based search interfaces support research. This study presents the results of eight full-scale usability tests of both the EBSCOhost Basic Search and Visual Search in the context of a large liberal arts university.

  12. Bridging the Gap between ABM and MAS: A Disaster-Rescue Simulation Using Jason and NetLogo

    Directory of Open Access Journals (Sweden)

    Wulfrano Arturo Luna-Ramirez

    2018-04-01

    Full Text Available An agent is an autonomous computer system situated in an environment to fulfill a design objective. Multi-Agent Systems aim to solve problems in a flexible and robust way by assembling sets of agents interacting in cooperative or competitive ways for the sake of possibly common objectives. Multi-Agent Systems have been applied to several domains ranging from many industrial sectors, e-commerce, health and even entertainment. Agent-Based Modeling, a sort of Multi-Agent Systems, is a technique used to study complex systems in a wide range of domains. A natural or social system can be represented, modeled and explained through a simulation based on agents and interactions. Such a simulation can comprise a variety of agent architectures like reactive and cognitive agents. Despite cognitive agents being highly relevant to simulate social systems due their capability of modelling aspects of human behaviour ranging from individuals to crowds, they still have not been applied extensively. A challenging and socially relevant domain are the Disaster-Rescue simulations that can benefit from using cognitive agents to develop a realistic simulation. In this paper, a Multi-Agent System applied to the Disaster-Rescue domain involving cognitive agents based on the Belief–Desire–Intention architecture is presented. The system aims to bridge the gap in combining Agent-Based Modelling and Multi-Agent Systems approaches by integrating two major platforms in the field of Agent-Based Modeling and Belief-Desire Intention multi-agent systems, namely, NetLogo and Jason.

  13. Discovery and Innovation: Advanced Search

    African Journals Online (AJOL)

    ... containing either term; e.g., education OR research; Use parentheses to create more complex queries; e.g., archive ((journal OR conference) NOT theses); Search for an exact phrase by putting it in quotes; e.g., "open access publishing"; Exclude a word by prefixing it with - or NOT; e.g. online -politics or online NOT politics ...

  14. Operating the GridPix detector in dark matter search experiments

    NARCIS (Netherlands)

    Schön, R.; Alfonsi, M.; Hemink, G.; Decowski, M.P.; van Bakel, N.; van der Graaf, H.

    2013-01-01

    The DARWIN (dark matter WIMP search with noble liquids) design study aims to use liquid argon and liquid xenon targets to look for nuclear recoils due to weakly interacting massive particles (WIMPs). To measure the recoil energy in dual-phase noble gas time projection chambers the combination of

  15. Filgrastim as a Rescue Therapy for Persistent Neutropenia in a Case of Dengue Hemorrhagic Fever with Acute Respiratory Distress Syndrome and Myocarditis

    Directory of Open Access Journals (Sweden)

    Desh Deepak

    2011-01-01

    Full Text Available Pathogenesis of dengue involves suppression of immune system leading to development of characteristic presentation of haematological picture of thrombocytopenia and leucopenia. Sometimes, this suppression in immune response is responsible for deterioration in clinical status of the patient in spite of all specific and supportive therapy. Certain drugs like steroids are used for rescue therapy in conditions like sepsis. We present a novel use of filgrastim as a rescue therapy in a patient with dengue hemorrhagic fever (DHF with acute respiratory distress syndrome (ARDS, myocarditis, and febrile neutropenia and not responding to standard management.

  16. Comparison of Temporal Parameters of Swimming Rescue Elements When Performed Using Dolphin and Flutter Kick with Fins - Didactical Approach

    Science.gov (United States)

    Rejman, Marek; Wiesner, Wojciech; Silakiewicz, Piotr; Klarowicz, Andrzej; Abraldes, J. Arturo

    2012-01-01

    The aim of this study was an analysis of the time required to swim to a victim and tow them back to shore, while perfoming the flutter-kick and the dolphin-kick using fins. It has been hypothesized that using fins while using the dolphin-kick when swimming leads to reduced rescue time. Sixteen lifeguards took part in the study. The main tasks performed by them, were to approach and tow (double armpit) a dummy a distance of 50m while applying either the flutter-kick, or the dolphin-kick with fins. The analysis of the temporal parameters of both techniques of kicking demonstrates that, during the approach to the victim, neither the dolphin (tmean = 32.9s) or the flutter kick (tmean = 33.0s) were significantly faster than the other. However, when used for towing a victim the flutter kick (tmean = 47.1s) was significantly faster when compared to the dolphin-kick (tmean = 52.8s). An assessment of the level of technical skills in competitive swimming, and in approaching and towing the victim, were also conducted. Towing time was significantly correlated with the parameter that linked the temporal and technical dimensions of towing and swimming (difference between flutter kick towing time and dolphin-kick towing time, 100m medley time and the four swimming strokes evaluation). No similar interdependency has been discovered in flutter kick towing time. These findings suggest that the dolphin-kick is a more difficult skill to perform when towing the victim than the flutter-kick. Since the hypothesis stated was not confirmed, postulates were formulated on how to improve dolphin-kick technique with fins, in order to reduce swimming rescue time. Key points The source of reduction of swimming rescue time was researched. Time required to approach and to tow the victim while doing the flutter kick and the dolphin-kick with fins was analyzed. The propulsion generated by dolphin-kick did not make the approach and tow faster than the flutter kick. More difficult skill to realize of

  17. Variation in Medicare Expenditures for Treating Perioperative Complications: The Cost of Rescue.

    Science.gov (United States)

    Pradarelli, Jason C; Healy, Mark A; Osborne, Nicholas H; Ghaferi, Amir A; Dimick, Justin B; Nathan, Hari

    2016-12-21

    Treating surgical complications presents a major challenge for hospitals striving to deliver high-quality care while reducing costs. Costs associated with rescuing patients from perioperative complications are poorly characterized. To evaluate differences across hospitals in the costs of care for patients surviving perioperative complications after major inpatient surgery. Retrospective cohort study using claims data from the Medicare Provider Analysis and Review files. We compared payments for patients who died vs patients who survived after perioperative complications occurred. Hospitals were stratified using average payments for patients who survived following complications, and payment components were analyzed across hospitals. Administrative claims database of surgical patients was analyzed at hospitals treating Medicare patients nationwide. This study included Medicare patients aged 65 to 100 years who underwent abdominal aortic aneurysm repair (n = 69 207), colectomy for cancer (n = 107 647), pulmonary resection (n = 91 758), and total hip replacement (n = 307 399) between 2009 and 2012. Data analysis took place between November 2015 and March 2016. Clinical outcome of surgery (eg, no complication, complication and death, or complication and survival) and the individual hospital where a patient received an operation. Risk-adjusted, price-standardized Medicare payments for an episode of surgery. Risk-adjusted perioperative outcomes were also assessed. The mean age for Medicare beneficiaries in this study ranged from 74.1 years (pulmonary resection) to 78.2 years (colectomy). The proportion of male patients ranged from 37% (total hip replacement) to 77% (abdominal aortic aneurysm repair), and most patients were white. Among patients who experienced complications, those who were rescued had higher price-standardized Medicare payments than did those who died for all 4 operations. Assessing variation across hospitals, payments for patients

  18. Modeling User Behavior and Attention in Search

    Science.gov (United States)

    Huang, Jeff

    2013-01-01

    In Web search, query and click log data are easy to collect but they fail to capture user behaviors that do not lead to clicks. As search engines reach the limits inherent in click data and are hungry for more data in a competitive environment, mining cursor movements, hovering, and scrolling becomes important. This dissertation investigates how…

  19. Bomb Threats and Bomb Search Techniques.

    Science.gov (United States)

    Department of the Treasury, Washington, DC.

    This pamphlet explains how to be prepared and plan for bomb threats and describes procedures to follow once a call has been received. The content covers (1) preparation for bomb threats, (2) evacuation procedures, (3) room search methods, (4) procedures to follow once a bomb has been located, and (5) typical problems that search teams will…

  20. The Temporal Dynamics of Visual Search: Evidence for Parallel Processing in Feature and Conjunction Searches

    Science.gov (United States)

    McElree, Brian; Carrasco, Marisa

    2012-01-01

    Feature and conjunction searches have been argued to delineate parallel and serial operations in visual processing. The authors evaluated this claim by examining the temporal dynamics of the detection of features and conjunctions. The 1st experiment used a reaction time (RT) task to replicate standard mean RT patterns and to examine the shapes of the RT distributions. The 2nd experiment used the response-signal speed–accuracy trade-off (SAT) procedure to measure discrimination (asymptotic detection accuracy) and detection speed (processing dynamics). Set size affected discrimination in both feature and conjunction searches but affected detection speed only in the latter. Fits of models to the SAT data that included a serial component overpredicted the magnitude of the observed dynamics differences. The authors concluded that both features and conjunctions are detected in parallel. Implications for the role of attention in visual processing are discussed. PMID:10641310