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Sample records for screw-rod stabilization two-year

  1. The effect of different screw-rod design on the anti-rotational torque: a biomechanical comparison of three conventional screw-rod constructs.

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    Huang, Zifang; Wang, Chongwen; Fan, Hengwei; Sui, Wenyuan; Li, Xueshi; Wang, Qifei; Yang, Junlin

    2017-07-28

    Screw-rod constructs have been widely used to correct spinal deformities, but the effects of different screw-rod systems on anti-rotational torque have not been determined. This study aimed to analyze the biomechanical effect of different rod-screw constructs on anti-rotational torque. Three conventional spinal screw-rod systems (Legacy, RF-F-10 and USSII) were used to test the anti-rotational torque in the material test machine. ANOVA was performed to evaluate the anti-rotational capacity of different pedicle screws-rod constructs. The anti-rotational torque of Legacy group, RF-F-10 group and USSII group were 12.3 ± 1.9 Nm, 6.8 ± 0.4 Nm, and 3.9 ± 0.8 Nm, with a P value lower than 0.05. This results indicated that the Legacy screws-rod construct could provide a highest anti-rotation capacity, which is 68% and 210% greater than RF-F-10 screw-rod construct and USSII screw-rod respectively. The anti-rotational torque may be mainly affected by screw cap and groove design. Our result showed the anti-rotational torque are: Legacy system > RF-F-10 system > USSII system, suggesting that appropriate rod-screw constructs selection in surgery may be vital for anti-rotational torque improvement and preventing derotation correction loss.

  2. The pedicle screw-rod system is an acceptable method of reconstructive surgery after resection of sacroiliac joint tumours

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    Yi-Jun Zhou

    2016-03-01

    Full Text Available Hemipelvic resections for primary bone tumours require reconstruction to restore weight bearing along anatomic axes. However, reconstruction of the pelvic arch remains a major surgical challenge because of the high rate of associated complications. We used the pedicle screw-rod system to reconstruct the pelvis, and the purpose of this investigation was to assess the oncology, functional outcome and complication rate following this procedure. The purpose of this study was to investigate the operative indications and technique of the pedicle screw-rod system in reconstruction of the stability of the sacroiliac joint after resection of sacroiliac joint tumours. The average MSTS (Musculoskeletal Tumour Society score was 26.5 at either three months after surgery or at the latest follow-up. Seven patients had surgery-related complications, including wound dehiscence in one, infection in two, local necrosis in four (including infection in two, sciatic nerve palsy in one and pubic symphysis subluxation in one. There was no screw loosening or deep vein thrombosis occurring in this series. Using a pedicle screw-rod after resection of a sacroiliac joint tumour is an acceptable method of pelvic reconstruction because of its reduced risk of complications and satisfactory functional outcome, as well as its feasibility of reconstruction for type IV pelvis tumour resection without elaborate preoperative customisation. Level of evidence: Level IV, therapeutic study.

  3. Clinical Outcomes of Posterior C1 and C2 Screw-Rod Fixation for Atlantoaxial Instability.

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    Işik, Hasan Serdar; Sandal, Evren; Çağli, Sedat

    2017-06-14

    In this study, we aimed at sharing our experiences and contributing to the literature by making a retrospective analysis of the patients we operated with screw-rod system for atlantoaxial instability in our clinic. Archive files of adult patients, who were operated for posterior C1-C2 stabilization with screw and rod in our clinic between January 2006 and January 2016, were analyzed. 28 patients, who had pre and post-operative images, follow-up forms and who were followed for at least one year, were analyzed. Preoperative clinical and radiological records, preoperative observations, postoperative complications, and clinical responses were evaluated. The average age of 28 patients (F:13 M:19) was 44.7 (21-73). Fixation was performed with C1-C2 screw-rod system on the basis of the following diagnoses; type 2 odontoid fracture (16), basilar invagination (5), C1-C2 instability (5), and atlantoaxial subluxation secondary to rheumatoid arthritis (2). Lateral mass screws were inserted at C1 segment. C2 screws inserted were bilateral pedicle in 12 cases, bilateral pars in 4, bilateral laminar in 8 and one side pars, one side laminar in 4 cases. There was no screw malposition. Neither implant failure nor recurrent instability was observed during follow-up. Significant clinical improvement was reported according to the assessments done with JOA and VAS scores. C1-C2 screw fixation is regarded as a more successful and safe method than other fixation methods in surgical treatment of atlantoaxial instability considering complications, success in reduction, fusion and fixation strength. C2 laminar screw technique is as successful as the other alternatives in fixation and fusion.

  4. Pedicle screw-rod fixation: a feasible treatment for dogs with severe degenerative lumbosacral stenosis.

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    Tellegen, Anna R; Willems, Nicole; Tryfonidou, Marianna A; Meij, Björn P

    2015-12-07

    Degenerative lumbosacral stenosis is a common problem in large breed dogs. For severe degenerative lumbosacral stenosis, conservative treatment is often not effective and surgical intervention remains as the last treatment option. The objective of this retrospective study was to assess the middle to long term outcome of treatment of severe degenerative lumbosacral stenosis with pedicle screw-rod fixation with or without evidence of radiological discospondylitis. Twelve client-owned dogs with severe degenerative lumbosacral stenosis underwent pedicle screw-rod fixation of the lumbosacral junction. During long term follow-up, dogs were monitored by clinical evaluation, diagnostic imaging, force plate analysis, and by using questionnaires to owners. Clinical evaluation, force plate data, and responses to questionnaires completed by the owners showed resolution (n = 8) or improvement (n = 4) of clinical signs after pedicle screw-rod fixation in 12 dogs. There were no implant failures, however, no interbody vertebral bone fusion of the lumbosacral junction was observed in the follow-up period. Four dogs developed mild recurrent low back pain that could easily be controlled by pain medication and an altered exercise regime. Pedicle screw-rod fixation offers a surgical treatment option for large breed dogs with severe degenerative lumbosacral stenosis with or without evidence of radiological discospondylitis in which no other treatment is available. Pedicle screw-rod fixation alone does not result in interbody vertebral bone fusion between L7 and S1.

  5. Minimal access direct spondylolysis repair using a pedicle screw-rod system: a case series

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    Mohi Eldin Mohamed

    2012-11-01

    Full Text Available Abstract Introduction Symptomatic spondylolysis is always challenging to treat because the pars defect causing the instability needs to be stabilized while segmental fusion needs to be avoided. Direct repair of the pars defect is ideal in cases of spondylolysis in which posterior decompression is not necessary. We report clinical results using segmental pedicle-screw-rod fixation with bone grafting in patients with symptomatic spondylolysis, a modification of a technique first reported by Tokuhashi and Matsuzaki in 1996. We also describe the surgical technique, assess the fusion and analyze the outcomes of patients. Case presentation At Cairo University Hospital, eight out of twelve Egyptian patients’ acute pars fractures healed after conservative management. Of those, two young male patients underwent an operative procedure for chronic low back pain secondary to pars defect. Case one was a 25-year-old Egyptian man who presented with a one-year history of axial low back pain, not radiating to the lower limbs, after falling from height. Case two was a 29-year-old Egyptian man who presented with a one-year history of axial low back pain and a one-year history of mild claudication and infrequent radiation to the leg, never below the knee. Utilizing a standardized mini-access fluoroscopically-guided surgical protocol, fixation was established with two titanium pedicle screws place into both pedicles, at the same level as the pars defect, without violating the facet joint. The cleaned pars defect was grafted; a curved titanium rod was then passed under the base of the spinous process of the affected vertebra, bridging the loose fragment, and attached to the pedicle screw heads, to uplift the spinal process, followed by compression of the defect. The patients were discharged three days after the procedure, with successful fusion at one-year follow-up. No rod breakage or implant-related complications were reported. Conclusions Where there is no

  6. Biomechanics of lumbar cortical screw-rod fixation versus pedicle screw-rod fixation with and without interbody support.

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    Perez-Orribo, Luis; Kalb, Samuel; Reyes, Phillip M; Chang, Steve W; Crawford, Neil R

    2013-04-15

    Seven different combinations of posterior screw fixation, with or without interbody support, were compared in vitro using nondestructive flexibility tests. To study the biomechanical behavior of a new cortical screw (CS) fixation construct relative to the traditional pedicle screw (PS) construct. The CS is an alternative to the PS for posterior fixation of the lumbar spine. The CS trajectory is more sagittally and cranially oriented than the PS, being anchored in the pars interarticularis. Like PS fixation, CS fixation uses interconnecting rods fastened with top-locking connectors. Stability after bilateral CS fixation was compared with stability after bilateral PS fixation in the setting of intact disc and with direct lateral interbody fixation (DLIF) or transforaminal lateral interbody fixation (TLIF) support. Standard nondestructive flexibility tests were performed in cadaveric lumbar specimens, allowing non-paired comparisons of specific conditions from 28 specimens (4 groups of 7) within a larger experiment of multiple hardware configurations. Condition tested and group from which results originated were as follows: (1) intact (all groups); (2) with L3-L4 bilateral PS-rods (group 1); (3) with bilateral CS-rods (group 2); (4) with DLIF (group 3); (5) with DLIF + CS-rods (group 4); (6) with DLIF + PS-rods (group 3); (7) with TLIF + CS-rods (group 2), and (8) with TLIF + PS-rods (group 2). To assess spinal stability, the mean range of motion, lax zone, and stiff zone at L3-L4 were compared during flexion-extension, lateral bending, and axial rotation. With intact disc, stability was equivalent after PS-rod and CS-rod fixation, except that PS-rod fixation was stiffer during axial rotation. With DLIF support, there was no significant difference in stability between PS-rod and CS-rod fixation. With TLIF support, PS-rod fixation was stiffer than CS-rod fixation during lateral bending. Bilateral CS-rod fixation provided about the same stability in cadaveric specimens

  7. [Effectiveness of U-shape titanium screw-rod fixation system with bone autografting for lumbar spondylolysis of young adults].

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    Pu, Xiaobing; Yang, Shuangshi; Cao, Haiquan; Jing, Xingquan; Yin, Jun

    2014-03-01

    To investigate the effectiveness of U-shape titanium screw-rod fixation system with bone autografting for lumbar spondylolysis of young adults. Between January 2008 and December 2011, 32 patients with lumbar spondylolysis underwent U-shape titanium screw-rod fixation system with bone autografting. All patients were male with an average age of 22 years (range, 19-32 years). The disease duration ranged from 3 to 24 months (mean, 14 months). L3 was involved in spondylolysis in 2 cases, L4 in 10 cases, and L5 in 20 cases. The preoperative visual analogue scale (VAS) and Oswestry disability index (ODI) scores were 8.0 +/- 1.1 and 75.3 +/- 11.2, respectively. The operation time was 80-120 minutes (mean, 85 minutes), and the blood loss was 150-250 mL (mean, 210 mL). Primary healing of incision was obtained in all patients without complications of infection and nerve symptom. Thirty-two patients were followed up 12-24 months (mean, 14 months). Low back pain was significantly alleviated after operation. The VAS and ODI scores at 3 months after operation were 1.0 +/- 0.5 and 17.6 +/- 3.4, respectively, showing significant differences when compared with preoperative ones (t = 30.523, P = 0.000; t = 45.312, P = 0.000). X-ray films and CT showed bone fusion in the area of isthmus defects, with the bone fusion time of 6-12 months (mean, 9 months). During follow-up, no secondary lumbar spondyloly, adjacent segment degeneration, or loosening or breaking of internal fixator was found. The U-shape titanium screw-rod fixation system with bone autografting is a reliable treatment for lumbar spondylolysis of young adults because of a high fusion rate, minimal invasive, and maximum retention of lumbar range of motion.

  8. In-place cement stabilized base reconstruction techniques interim report : "construction and two year evaluation".

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    2002-08-01

    The purpose of this research was to evaluate the effectiveness of soil cement shrinkage crack mitigation techniques. The contents of this report reflect an evaluation of the construction of the test sections and a two-year evaluation of the test sect...

  9. Two-Year Stability and Change of Schizotypal, Borderline, Avoidant, and Obsessive-Compulsive Personality Disorders

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    Grilo, Carlos M.; Sanislow, Charles A.; Gunderson, John G.; Pagano, Maria E.; Yen, Shirley; Zanarini, Mary C.; Shea, Tracie M.; Skodol, Andrew E.; Stout, Robert L.; Morey, Leslie C.; McGlashan, Thomas H.

    2004-01-01

    The authors examined the stability of schizotypal (STPD), borderline (BPD), avoidant (AVPD) and obsessive-compulsive (OCPD) personality disorders (PDs) over 2 years of prospective multiwave follow-up. Six hundred thirty-three participants recruited at 4 collaborating sites who met criteria for 1 or more of the 4 PDs or for major depressive…

  10. Two-Year Diagnostic Stability in Early-Onset First-Episode Psychosis

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    Castro-Fornieles, Josefina; Baeza, Immaculada; de la Serna, Elena; Gonzalez-Pinto, Ana; Parellada, Mara; Graell, Montserrat; Moreno, Dolores; Otero, Soraya; Arango, Celso

    2011-01-01

    Background: Only one study has used a prospective method to analyze the diagnostic stability of first psychotic episodes in children and adolescents. The Child and Adolescent First-Episode Psychosis Study (CAFEPS) is a 2-year, prospective longitudinal study of early-onset first episodes of psychosis (EO-FEP). Aim: To describe diagnostic stability…

  11. Two-Year Stability and Change of Schizotypal, Borderline, Avoidant, and Obsessive–Compulsive Personality Disorders

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    Grilo, Carlos M.; Shea, M. Tracie; Sanislow, Charles A.; Skodol, Andrew E.; Gunderson, John G.; Stout, Robert L.; Pagano, Maria E.; Yen, Shirley; Morey, Leslie C.; Zanarini, Mary C.; McGlashan, Thomas H.

    2012-01-01

    The authors examined the stability of schizotypal (STPD), borderline (BPD), avoidant (AVPD) and obsessive– compulsive (OCPD) personality disorders (PDs) over 2 years of prospective multiwave follow-up. Six hundred thirty-three participants recruited at 4 collaborating sites who met criteria for 1 or more of the 4 PDs or for major depressive disorder (MDD) without PD were assessed with semistructured interviews at baseline, 6, 12, and 24 months. Lifetable survival analyses revealed that the PD groups had slower time to remission than the MDD group. Categorically, PD remission rates range from 50% (AVPD) to 61% (STPD) for dropping below diagnostic threshold on a blind 24-month reassessment but range from 23% (STPD) to 38% (OCPD) for a more stringent definition of improvement. Dimensionally, these findings suggest that PDs may be characterized by maladaptive trait constellations that are stable in their structure (individual differences) but can change in severity or expression over time. PMID:15482035

  12. Stability of narcissistic personality disorder: tracking categorical and dimensional rating systems over a two-year period.

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    Vater, Aline; Ritter, Kathrin; Strunz, Sandra; Ronningstam, Elsa F; Renneberg, Babette; Roepke, Stefan

    2014-07-01

    Personality disorders are characterized as temporally stable patterns of symptoms (APA, 2000). However, evidence on the stability of narcissistic personality disorder (NPD) is generally lacking. This study tracked the prevalence and remission rates of individual criteria for NPD over the course of 2 years. In addition, the stability of dimensional personality pathology in patients with NPD (assessed with the Dimensional Assessment of Personality Pathology, DAPP-BQ) was assessed over time. A sample of 96 patients with a diagnosis of NPD was recruited at baseline. Forty patients participated in the follow-up assessment 2 years later. Our results indicate a moderate remission rate (53%) for NPD as a categorical diagnosis. However, single NPD criteria differed in their prevalence and temporal stability, similar to findings for other personality disorders. Moreover, scores on dimensional subscales of the DAPP-BQ remained stable over time. Theoretical implications are discussed. (c) 2014 APA, all rights reserved.

  13. Stability of functional impairment in patients with schizotypal, borderline, avoidant, or obsessive–compulsive personality disorder over two years

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    SKODOL, ANDREW E.; PAGANO, MARIA E.; BENDER, DONNA S.; SHEA, M. TRACIE; GUNDERSON, JOHN G.; YEN, SHIRLEY; STOUT, ROBERT L.; MOREY, LESLIE C.; SANISLOW, CHARLES A.; GRILO, CARLOS M.; ZANARINI, MARY C.; McGLASHAN, THOMAS H.

    2012-01-01

    Background A defining feature of personality disorder (PD) is an enduring pattern of inner experience and behavior that is stable over time. Follow-up and follow-along studies have shown considerable diagnostic instability of PDs, however, even over short intervals. What, then, about personality disorder is stable ? The purpose of this study was to determine the stability of impairment in psychosocial functioning in patients with four different PDs, in contrast to patients with major depressive disorder (MDD) and no PD, prospectively over a 2-year period. Method Six hundred treatment-seeking or treated patients were recruited primarily from clinical services in four metropolitan areas of the Northeastern USA. Patients were assigned to one of five diagnostic groups: schizotypal (STPD) (n=81), borderline (BPD) (n=155), avoidant (AVPD) (n=137), or obsessive–compulsive (OCPD) (n=142) personality disorders or MDD and no PD (n=85), based on the results of semi-structured interview assessments and self-report measures. Impairment in psychosocial functioning was measured using the Longitudinal Interval Follow-up Evaluation (LIFE) at baseline and at three follow-up assessments. Results Significant improvement in psychosocial functioning occurred in only three of seven domains of functioning and was largely the result of improvements in the MDD and no PD group. Patients with BPD or OCPD showed no improvement in functioning overall, but patients with BPD who experienced change in personality psychopathology showed some improvement in functioning. Impairment in social relationships appeared most stable in patients with PDs. Conclusion Impairment in functioning, especially social functioning, may be an enduring component of personality disorder. PMID:15841879

  14. Therapeutic efficacy of pedicle screw-rod internal fixation after one-stage posterior transforaminal lesion debridement and non-structural bone grafting for tuberculosis of lumbar vertebra

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    Jia-ming LIU

    2015-11-01

    Full Text Available Objective To evaluate the efficacy and safety of pedicle screw-rod internal fixation after one-stage posterior transforaminal lesion debridement and non-structural bone grafting in the treatment of tuberculosis of mono-segmental lumbar vertebra. Methods From January 2010 to April 2013, 21 patients (9 males and 12 females with an average age of 49.1 years with mono-segmental tuberculosis of lumbar vertebra underwent surgery in our hospital were included. Eight patients had neurological deficit. The focus of tuberculosis was located on one side of the vertebral body, and all the patients had obvious signs of bone destruction on CT and MRI. All the patients were given anti-tuberculosis chemotherapy for 2-3 weeks before surgery. The local bone chips and autologous iliac cancellous bone were used as the intervertebral bone graft. Postoperative plain radiographs and CT were obtained to evaluate the fusion rate and degree of lumbar lordosis. The visual analogue scale score (VAS, erythrocyte sedimentation rate (ESR, and C-reactive protein (CRP before and after operation, and at final follow-up date were recorded. Results All the patients were followed up for 25.3±4.2 months. The mean operation time was 157±39 minutes, and the average blood loss was 470±143ml. The fusion rate of the interbody bone graft was 95.2%, with an average fusion period of 6.1±2.5 months. The neurological function was improved by 100%, and no severe complication or neurological injury occured. The preoperative and postoperative lordosis angles of the lumbar spine were 21.4°±5.7° and 33.6°±3.1°, respectively, and it was 31.3°±2.7° at the final follow up. The preoperative and postoperative VAS scores were 7.8±2.6 and 2.4±1.7 respectively, and it was 0.9±0.7 at the final follow up. The ESR and CRP were significantly decreased 3 months after surgery, and they became normal at 6 months. Conclusion Pedicle screw-rod internal fixation after one-stage posterior

  15. Investigation of the leaching behavior of lead in stabilized/solidified waste using a two-year semi-dynamic leaching test.

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    Xue, Qiang; Wang, Ping; Li, Jiang-Shan; Zhang, Ting-Ting; Wang, Shan-Yong

    2017-01-01

    Long-term leaching behavior of contaminant from stabilization/solidification (S/S) treated waste stays unclear. For the purpose of studying long-term leaching behavior and leaching mechanism of lead from cement stabilized soil under different pH environment, semi-dynamic leaching test was extended to two years to investigate leaching behaviors of S/S treated lead contaminated soil. Effectiveness of S/S treatment in different scenarios was evaluated by leachability index (LX) and effective diffusion coefficient (D e ). In addition, the long-term leaching mechanism was investigated at different leaching periods. Results showed that no significant difference was observed among the values of the cumulative release of Pb, D e and LX in weakly alkaline and weakly acidic environment (pH value varied from 5.00 to 10.00), and all the controlling leaching mechanisms of the samples immersed in weakly alkaline and weakly acidic environments turned out to be diffusion. Strong acid environment would significantly affect the leaching behavior and leaching mechanism of lead from S/S monolith. The two-year variation of D e appeared to be time dependent, and D e values increased after the 210 th day in weakly alkaline and weakly acidic environment. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. NONFUSION STABILIZATION IN THE DEGENERATIVE LUMBAR SPINE DISEASES

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    Matjaž Voršič

    2009-04-01

    Conclusions Cosmic is a posterior dynamic nonfusion pedicle screw-rod system for the stabilization of the lumbar vertebral column. It represents the new step in the development of the spinal instrumentation and can efficiently replace the spondylodesis in the treatment of painful degenerative diseases of the lumbar spine.

  17. Comparison of Direct Pars Repair Techniques of Spondylolysis in Pediatric and Adolescent Patients: Pars Compression Screw Versus Pedicle Screw-Rod-Hook.

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    Karatas, Ali F; Dede, Ozgur; Atanda, Alfred A; Holmes, Larry; Rogers, Kenneth; Gabos, Peter; Shah, Suken A

    2016-08-01

    Retrospective clinical cohort study. To compare the clinical and radiographic outcomes of patients who were treated with intrasegmental pars fixation by either laminar compression screw (LS) or a pedicle screw, rod, and laminar hook (PSRH) construct. Spondylolysis is a nonunion defect of the pars interarticularis. In symptomatic spondylolysis, direct repair of the pars interarticularis defect can preserve motion and prevent abnormal stresses at the adjacent levels. Sixteen patients who failed nonoperative treatment and underwent direct pars repair by using LS (n=9) or PSRH (n=7) constructs were included in the study. Clinical outcome was assessed by using the MacNab criteria. Radiologic fusion and complications were evaluated using plain radiographs or computed tomography images and patient charts. The healing rate was 100% after 6 months. The healing time was similar in both the groups: LS, 6.5 months; PSRH, 6.2 months. Patients with PSRH (5.9 mo) were more likely to return to sports earlier relative to patients with LS (7.7 mo). There were no complications in the LS group; in the PSRH group, 1 patient had mild sensory deficit and 2 had superficial wound infections. The MacNab criteria for pain assessment showed an excellent or good outcome in 8 of 9 patients in LS group and 6 of 7 patients in PSRH group. Relative to LS patients, there was a significant increase in surgical time and estimated blood loss among PSRH patients. Either of the mentioned 2 techniques appears to produce acceptable results. Biplanar fluoroscopy and navigation systems could minimize the risk of screw misplacement with LS construct. Familiarity with the various fixation techniques will allow the surgeon to select the most appropriate surgical technique.

  18. Two-year stability of individual differences in (para)sympathetic and HPA-axis responses to public speaking in childhood and adolescence.

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    van den Bos, Esther; Westenberg, P Michiel

    2015-03-01

    Long-term stability of individual differences in stress responses has repeatedly been demonstrated in adults, but few studies have investigated the development of stability in adolescence. The present study was the first to investigate the stability of individual differences in heart rate, parasympathetic (RMSSD, pNN50, HF), sympathetic (LF/HF, SC), and HPA-axis (salivary cortisol) responses in a youth sample (8-19 years). Responses to public speaking were measured twice over 2 years. Stability was moderate for absolute responses and task delta responses of HR, RMSSD, pNN50, and HF. Stability was lower for SC and task delta responses of LF/HF and cortisol. Anticipation delta responses showed low stability for HR and cortisol. The latter was moderated by age or puberty, so that individual differences were more stable in more mature individuals. The results support the suggestion that stress responses may be reset during adolescence, but only for the HPA axis. © 2014 Society for Psychophysiological Research.

  19. Assessment and Stability of Early Learning Abilities in Preterm and Full-Term Infants across the First Two Years of Life

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    Lobo, Michele A.; Galloway, James C.

    2013-01-01

    Infants born preterm have increased risk for learning disabilities yet we lack assessments to successfully detect these disabilities in early life. We followed 23 full-term and 29 preterm infants from birth through 24 months to assess for differences in and stability of learning abilities across time. Measures included the Bayley-III cognitive…

  20. Fukushima two year processing update

    Energy Technology Data Exchange (ETDEWEB)

    Denton, Mark S.; Mertz, Joshua [Kurion, Inc., P.O. Box 5901, Oak Ridge, Tennessee 37831 (United States)

    2013-07-01

    On March 11, 2011, now two years ago, the magnitude 9.0 Great East Japan earth quake, Tohoku, hit off the Fukushima coast of Japan. This was one of the most powerful earthquakes in recorded history and the most powerful one known to have hit Japan. The ensuing tsunami devastated a huge area resulting in some 25,000 persons confirmed dead or missing. The perfect storm was complete when the tsunami then found the four-reactor, Fukushima- Daiichi Nuclear Station directly in its destructive path. Some 2 million people were evacuated from a fifty mile radius of the area and evaluation and cleanup began. A tremendous effort has been made, by many nationalities, since this time to restore this damaged plant and surrounding area and to return a great deal of the residents to their homes and farm lands. While most of the outcome of this unprecedented natural and manmade disaster was negative, both in Japan and worldwide, there have been some extremely valuable lessons learned and new emergency recovery technologies and systems developed to cope with the aftermath of this disaster. This paper describes new technology developed to selectively remove radioactive materials dangerous to workers, local citizens, and the natural environment from seawater used to cool the damaged reactors at Fukushima. As always, the mother of invention is necessity. (authors)

  1. Stability of return to work after a coordinated and tailored intervention for sickness absence compensation beneficiaries with mental health problems: results of a two-year follow-up study.

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    Martin, Marie H T; Nielsen, Maj Britt D; Pedersen, Jacob; Rugulies, Reiner

    2015-01-01

    Mental health problems (MHPs) are increasingly common as reasons for long-term sickness absence. However, the knowledge of how to promote a stable return to work (RTW) after sickness absence due to MHPs is limited. The purpose of this study was to assess the effects of a multidisciplinary, coordinated and tailored RTW-intervention in terms of stability of RTW, cumulative sickness absence and labour market status after 2 years among sickness absence compensation beneficiaries with MHPs. In a quasi-randomised, controlled trial, we followed recipients of the intervention (n = 88) and of conventional case management (n = 80) for 2 years to compare their risk of recurrent sickness absence and unemployment after RTW, their cumulative sickness absence and their labour market status after 2 years. We found no statistically significant intervention effect in terms of the risk of recurrent sickness absence or unemployment. Intervention recipients had more cumulated sickness absence in year one (mean difference = 58 days; p sickness absence or improved labour market status after 2 years when compared to conventional case management. Evidence for effective return-to-work (RTW) interventions for people with mental health problems is limited, as most research to date has been done in the context of musculoskeletal disorders. A complex, multidisciplinary intervention, detached from the workplace, does not appear to improve the stability of RTW and may actually lead to more sickness absence days and less self-support when compared to conventional case management of sickness absence beneficiaries in Denmark. A stronger focus on cooperation with social insurance officers and employers may produce better results.

  2. Two-year prevalence and stability of individual DSM-IV criteria for schizotypal, borderline, avoidant, and obsessive-compulsive personality disorders: toward a hybrid model of axis II disorders.

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    McGlashan, Thomas H; Grilo, Carlos M; Sanislow, Charles A; Ralevski, Elizabeth; Morey, Leslie C; Gunderson, John G; Skodol, Andrew E; Shea, M Tracie; Zanarini, Mary C; Bender, Donna; Stout, Robert L; Yen, Shirley; Pagano, Maria

    2005-05-01

    This study tracked the individual criteria of four DSM-IV personality disorders-borderline, schizotypal, avoidant, and obsessive-compulsive personality disorders-and how they change over 2 years. This clinical sample of patients with personality disorders was derived from the Collaborative Longitudinal Personality Disorders Study and included all participants with borderline, schizotypal, avoidant, or obsessive-compulsive personality disorder for whom complete 24-month blind follow-up assessments were obtained (N=474). The authors identified and rank-ordered criteria for each of the four personality disorders by their variation in prevalence and changeability (remission) over time. The most prevalent and least changeable criteria over 2 years were paranoid ideation and unusual experiences for schizotypal personality disorder, affective instability and anger for borderline personality disorder, feeling inadequate and feeling socially inept for avoidant personality disorder, and rigidity and problems delegating for obsessive-compulsive personality disorder. The least prevalent and most changeable criteria were odd behavior and constricted affect for schizotypal personality disorder, self-injury and behaviors defending against abandonment for borderline personality disorder, avoiding jobs that are interpersonal and avoiding potentially embarrassing situations for avoidant personality disorder, and miserly behaviors and strict moral behaviors for obsessive-compulsive personality disorder. These patterns highlight that within personality disorders the relatively fixed criteria are more trait-like and attitudinal, whereas the relatively intermittent criteria are more behavioral and reactive. These patterns suggest that personality disorders are hybrids of traits and symptomatic behaviors and that the interaction of these elements over time helps determine diagnostic stability. These patterns may also inform criterion selection for DSM-V.

  3. Cognitive Development: Two-Year-Old

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    ... Gradeschool Teen Young Adult Healthy Children > Ages & Stages > Toddler > Cognitive Development: Two-Year-Old Ages & Stages Listen Español Text Size Email Print Share Cognitive Development: ... Content Article Body Think back to your child’s infancy and early toddler months. That was a time when he learned ...

  4. Cassini at Saturn: The Final Two Years

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    Spilker, L.; Edgington, S.; Altobelli, N.

    2015-10-01

    After 11 years in orbit, the Cassini-Huygens Mission to Saturn, a collaboration of NASA, ESA, and ASI, continues to wow the imagination and reveal unprecedented findings. Every year Cassini produces answers to questions raised by the Voyager flybys, while at the same time posing new questions that can only be answered with a long duration mission using a flagship-class spacecraft. Here we sample a few of Cassini's discoveries from the past year and give an overview of Cassini's final two years.

  5. US Strategic Plan: two years on

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    In the two years since it issued its Strategic Plan for Building New Nuclear Power Plants, the US nuclear power industry says significant progress has been achieved. The plan's major points call for completing the engineering for advanced reactor designs over the next five years; identifying suitable sites for new nuclear plants; achieving stable regulatory conditions so investors can be assured of earning a fair return on financing for new plants; improving the performance of existing nuclear plants; resolving the waste problems; and improving public acceptance of nuclear power. (author)

  6. Followership Styles at a Two-Year Higher Education Institution

    Science.gov (United States)

    Ellie, Bethine J.

    2017-01-01

    This study examined relationships among reported followership styles and employee demographics at one Midwestern two-year college. It replicated a study by Ghislieri, Gatti, and Cortese (2015), and provided a baseline measure of followership styles at one Midwestern two-year college. It found that conformist follower styles showed the highest…

  7. Factors Influencing Japanese Women to Choose Two-Year Colleges

    Science.gov (United States)

    Anzai, Shinobu

    2009-01-01

    Two-year colleges in Japan have traditionally absorbed the major portion of female college entrants due at least partially to long-held gender stereotypes: women are to prepare themselves for marriage and homemaking at a two-year college. Recently, Japanese women began to explore selfhood outside the traditional realm of motherhood and womanhood.…

  8. Two years after the storms; 2 ans apres les tempetes

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-12-01

    This document takes stock on the power distribution repair, two years after the storms of december 1999 in France. It also presents the new organization (FIRE) developed to face such natural or accidental disasters. (A.L.B.)

  9. TTI reports on its first two years of programming | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2011-03-17

    Mar 17, 2011 ... During its first two years, the Think Tank Initiative has supported 52 institutions in four regions. Read the report​ to learn about our progress, our grantees, and our plans for the future.

  10. Psychological distress two years after diagnosis of breast cancer

    DEFF Research Database (Denmark)

    Bleiker, E M; Pouwer, F; Van Der Ploeg, Henk M

    2000-01-01

    The present prospective study aimed at (1) investigating the frequency of high levels of psychological distress in women with early-stage breast cancer almost two years after diagnosis and (2) identifying characteristics associated with long-term distress. One hundred and seventy women participated...... of surgery). At the second measurement, subjective distress was assessed for a second time by means of the Impact of Events Scale (IES). Almost two years after diagnosis, 16% of the women reported a high level of psychological distress as measured by the Intrusion scale (IES). Best predictors of a high level...

  11. High School Physics, Two-Year Colleges, and Physics Majors

    Science.gov (United States)

    White, Susan C.

    2013-01-01

    We have just completed the data collection for our 2012-13 Nationwide Survey of High School Physics and expect to have results to report in the spring. In the interim, we will take a look at physics in two-year colleges (TYCs). In 2007, we surveyed undergraduate seniors in degree-granting physics departments, and we asked these students if they…

  12. Developing Early Undergraduate Research at a Two-Year College

    Science.gov (United States)

    Sibbernsen, Kendra

    2013-01-01

    Two-year college (TYC) physics teachers are not often required to provide student research experiences as a part of their contracted duties. However, some TYC physics faculty members are interested in developing research opportunities for their freshman- and sophomore-level students, often called "early undergraduate research" (EUR).…

  13. The Social Science Curriculum of the Two-Year College.

    Science.gov (United States)

    Friedlander, Jack

    1980-01-01

    Describes a nationwide study to identify: (1) the representation of different areas within the social sciences (i.e. anthropology, economics, history, political science, psychology, social/ethnic studies, sociology, and interdisciplinary social sciences) in the two-year college curriculum, and (2) which courses were offered for transfer,…

  14. Prevalence of active trachoma two years after control activities ...

    African Journals Online (AJOL)

    The prevalence of TF/TI showed significant reduction (p-value <0.001) in all five districts and overall in the two regions. Conclusion: Trachoma control activities over a two-year period in two regions in Ghana had led to significant reduction in the prevalence of active disease. Integrated surveillance and active monitoring will ...

  15. Characteristics of Millennial Students at a Two-Year College

    Science.gov (United States)

    Fenske, Susanne Kelly

    2011-01-01

    The purpose of this research is to describe the degree to which Millennial students who attend two-year colleges exhibit the characteristics of the seven Millennial generation characteristics. Howe and Strauss (2007) purport that the Millennials exhibit seven key characteristics in their behavior: Special, Sheltered, Confident, Team-oriented,…

  16. Selected Collective Bargaining Agreements of Michigan Two-Year Colleges.

    Science.gov (United States)

    National Education Association, Washington, DC.

    Collective bargaining agreements of 19 selected Michigan two-year colleges are presented, representing contracts in effect in 1987. Contracts for the following colleges are included: Alpena Community College, Bay de Noc Community College, Gogebic Community College, Grand Rapids Junior College, Kalamazoo Valley Community College, Kellogg Community…

  17. [Information About New Mexico Two-Year Colleges].

    Science.gov (United States)

    New Mexico State Board of Educational Finance, Santa Fe.

    In a collection of statistical summaries, the following information regarding New Mexico two-year colleges is presented for each institution: (1) 1977-78 average full-time faculty salaries; (2) 1975-76 unrestricted expenditures for instruction, academic support, student services, institutional support, and plant operation; (3) local district tax…

  18. Business Management Concept Areas for Two-Year Postsecondary Institutions

    Science.gov (United States)

    Gentry, Lee; Gentry, Eileen

    1978-01-01

    A core of educational concepts in business ownership and management for two-year postsecondary institutions is outlined: economic systems, economic decisionmaking, organizational structure, management principles, marketing factors, accounting, legal obligations, financial structure, risk-taking and insurance, taxes, data processing, and social…

  19. Can bilingual two-year-olds code-switch?

    Science.gov (United States)

    Lanza, E

    1992-10-01

    Sociolinguists have investigated language mixing as code-switching in the speech of bilingual children three years old and older. Language mixing by bilingual two-year-olds, however, has generally been interpreted in the child language literature as a sign of the child's lack of language differentiation. The present study applies perspectives from sociolinguistics to investigate the language mixing of a bilingual two-year-old acquiring Norwegian and English simultaneously in Norway. Monthly recordings of the child's spontaneous speech in interactions with her parents were made from the age of 2;0 to 2;7. An investigation into the formal aspects of the child's mixing and the context of the mixing reveals that she does differentiate her language use in contextually sensitive ways, hence that she can code-switch. This investigation stresses the need to examine more carefully the roles of dominance and context in the language mixing of young bilingual children.

  20. Periprosthetic femoral fracture within two years after total hip replacement:

    DEFF Research Database (Denmark)

    Thien, T. M.; Chatziagorou, G.; Garellick, G.

    2014-01-01

    BACKGROUND: We used the Nordic Arthroplasty Register Association database to evaluate whether age, sex, preoperative diagnosis, fixation, and implant design influence the risk of revision arthroplasty due to periprosthetic fracture within two years from operation of a primary total hip replacement....... METHODS: Included in the study were 325,730 cemented femoral stems and 111,899 uncemented femoral stems inserted from 1995 to 2009. Seven frequently used stems (two cemented stems [Exeter and Lubinus SP II] and five uncemented stems [Bi-Metric, Corail, CLS Spotorno, ABG I, and ABG II]) were specifically...... studied. RESULTS: The incidence of revision at two years was low: 0.47% for uncemented stems and 0.07% for cemented stems. Uncemented stems were much more likely to have this complication (relative risk, 8.72 [95% confidence interval, 7.37 to 10.32]; p

  1. Osteogénesis por distracción en defectos mandibulares y su estabilidad esquelética a los 2 años de tratados Osteogenesis by distraction in mandibular defects and skeletal stability after two years of treatment

    Directory of Open Access Journals (Sweden)

    Dadonim Vila Morales

    2011-03-01

    Full Text Available El presente estudio tiene como objetivo mostrar los resultados de la estabilidad esquelética a los 2 años de operados, de los primeros pacientes con hipoplasias mandibulares tratados con distracción osteogénica en nuestro país. Se trataron 11 hemimandíbulas en 7 pacientes con distracción osteogénica mandibular, con distractores marca Leibinger. El periodo de latencia fue de 72 horas, la distracción mandibular se aplicó a razón de 1,0 mm cada 12 horas y la contención fue de 8 semanas. Luego se inició el tratamiento ortodóncico posquirúrgico. Se evaluaron los resultados a través de estudios cefalométricos antes de la intervención, luego y a los 2 años del tratamiento hubo cambios esqueléticos posoperatorios significativos en las mediciones angulares cefalométricas SNB y ANB, con pTo show the results of the skeletal stability after 2 years of to be operated on from the first patients presenting with mandibular hypoplasias treated with osteogenic distraction in our country. Eleven hemi-mandibles in 7 patients using mandibular osteogenic distraction with Leibinger distraction device. Latency period was of 72 hours, mandibular distraction was applied at a rate of 1,0 mm each 12 hours and fixation was of 8 weeks. Then, postsurgical orthodontic treatment was started. There were significant postoperative skeletal changes. Results were assessed by cephalometry studies before intervention, after and at 2 years of treatment. Also, there were significant postoperative skeletal changes in SNB and ANB with p< 0,05. The arithmetic mean of the osteodistraction achieve in branch was of 7,5 mm and in the body it was of 8,0 mm. At 2 years there remain a mandibular bone stability of 88,8 % qualified as good. Occlusal changes were favorable. There were not complications involving the good course of patients treated. It was shown that the bone distraction is an effective method for treatment of mandibular defects.

  2. Perceptions of teachers' general and informational feedback and intrinsic motivation in physical education: two-year effects.

    Science.gov (United States)

    Koka, Andre; Hein, Vello

    2006-10-01

    Relative change or stability of perceived positive general feedback and perceived informational feedback and their influence on students' intrinsic motivation in physical education over two years were examined. 302 students, ages 11 to 15 years, responded to the Perception of Teacher's Feedback questionnaire. Two years later, these students filled out the questionnaire again, along with a modified version of the Sport Motivation Scale. Analysis showed that both types of perceived feedback exhibited moderate stability over the two years. Perceived positive general feedback demonstrated a significant direct effect on students' intrinsic motivation measured concurrently in physical education. Further, fixing to zero the effect of perceived positive general feedback on intrinsic motivation measured concurrently, an effect emerged over the two years.

  3. Stabilization

    Directory of Open Access Journals (Sweden)

    Muhammad H. Al-Malack

    2016-07-01

    Full Text Available Fuel oil flyash (FFA produced in power and water desalination plants firing crude oils in the Kingdom of Saudi Arabia is being disposed in landfills, which increases the burden on the environment, therefore, FFA utilization must be encouraged. In the current research, the effect of adding FFA on the engineering properties of two indigenous soils, namely sand and marl, was investigated. FFA was added at concentrations of 5%, 10% and 15% to both soils with and without the addition of Portland cement. Mixtures of the stabilized soils were thoroughly evaluated using compaction, California Bearing Ratio (CBR, unconfined compressive strength (USC and durability tests. Results of these tests indicated that stabilized sand mixtures could not attain the ACI strength requirements. However, marl was found to satisfy the ACI strength requirement when only 5% of FFA was added together with 5% of cement. When the FFA was increased to 10% and 15%, the mixture’s strength was found to decrease to values below the ACI requirements. Results of the Toxicity Characteristics Leaching Procedure (TCLP, which was performed on samples that passed the ACI requirements, indicated that FFA must be cautiously used in soil stabilization.

  4. Goiania's radioactive accident - Evolutive description two years after

    International Nuclear Information System (INIS)

    Lamarck, P. de; Almeida Lignelli, O.J. de; Sobrinho, A.B.

    1990-01-01

    The authors lead a brief review of three patients that undergone lesions caused by ionizing radiations at the Goiania's radioactive accident, two years after. They describe the actual conditions of the skin lesions, hematologic values, sequels, diagnostic and therapeutics procedures on the follow up of this patients. They still make a comparative study between nuclear weapon's victims at Hiroshima and Nagasaki events (2 sup(nd) World War) and Goiania accident s victims. In their conclusions, the authors point out the importance in detecting early lesions, diseases or late sequels, due to radioactive expositions. (author)

  5. The A.Q. Khan case, two years later

    International Nuclear Information System (INIS)

    Tertrais, Bruno

    2005-01-01

    Two years after the first public revelations on the importance of Pakistani nuclear trades, the author proposes a critical comment of the so-called A.Q. Khan case. He outlines that making A.Q. Khan the father of the Pakistani atomic bomb is exaggerated, indicates what Khan actually exported (some know-how on head militarization, and on uranium centrifugation). He identifies Khan's motivations and outlines the different situations and relationships associated with the different concerned countries (Iran, North Korea, Libya)

  6. Two years of aerosol pollution monitoring in Singapore: a review

    International Nuclear Information System (INIS)

    Orlic, I.; Wen, X.; Ng, T.H.; Tang, S.M.

    1999-01-01

    An aerosol sampling campaign was initiated more than two years ago in Singapore. The aim was to determine the average elemental concentrations in fine and coarse aerosol fractions as well as to identify major pollution sources and their impact. For that purpose, two air samplers were employed at two different sampling locations; one sampler was a fine particulate aerosol sampler (PM2.5) located at the vicinity of a major industrial area. The other was a stacked filter unit (SFU) sampler designed for collection of fine and coarse fractions (PM2.5 and PM10) and installed in the residential area. Samples were taken typically twice a week and in several occasions daily. During the period of two years more than 700 aerosol samples were collected and analyzed using PIXE and RBS techniques. All samples were analyzed for 18 elements ranging between Na, Mg, Al, etc. up to As and Pb. Large daily and seasonal variations were found for most of the elements. These variations are attributed mainly to meteorological changes, in particular changes in wind speed and direction. On several occasions, short term sampling was performed to identify fingerprints of major pollution sources such as road traffic, refineries, as well as the rain-forest fires in neighboring countries. A summary of our findings is presented and discussed

  7. An orthopaedic geriatric rehabilitation unit: the first two years experience.

    Science.gov (United States)

    Sainsbury, R; Gillespie, W J; Armour, P C; Newman, E F

    1986-08-13

    Experience of the first two years of an orthopaedic geriatric rehabilitation unit is described. There were 325 admissions comprising 271 females and 54 males. The predominant diagnosis was fracture of the proximal femur. Average length of stay in the unit was 43 days for males and 36.7 days for females. 75.9% of patients admitted from home returned there and 66.1% of patients admitted from residential care returned to similar accommodation. In the first year there was a fall of 13.5 days in the average length of stay for elderly females with proximal femoral fracture, resulting in 2175 less bed days for this diagnosis. This improvement has continued.

  8. Pulmonary Hernia in a Two-Year-Old Child

    Directory of Open Access Journals (Sweden)

    Jenna Fine

    2014-01-01

    Full Text Available Pulmonary hernia, also known as lung herniation or intercostal herniation, is best explained as the lung parenchyma protruding beyond the confines of the thoracic wall. This rare finding can be classified as congenital or acquired. Acquired pulmonary herniations are often the complication of blunt or penetrating trauma to the chest wall. This report describes a two-year-old male who fell onto a rigid post, striking his left lower chest. Imaging studies demonstrated a small pneumothorax as well as pulmonary herniation. The patient underwent a diagnostic thoracoscopy and repair of a pulmonary hernia within the 7th intercostal space without complication. In this case report, we aim to add to the limited body of existing literature on the surgical management of pulmonary hernias.

  9. Fournier’s Gangrene in a Two Year Old Child: A Case Report

    Science.gov (United States)

    Bains, Satinder Pal Singh; Singh, Vikram; Jain, Amit; Arry, Vivek

    2014-01-01

    Necrotizing fasciitis of the perineum and external genitalia is a life-threatening infective gangrene, primarily seen in adults. It may be seen at any age but it is relatively uncommon in children. Here, we report a case of Fournier’s gangrene in a two year old male child who was treated aggressively with broad spectrum antibiotics and early surgical debridement with hemodynamic stabilization. Even though no obvious precipitating cause was identified, hygiene was thought to be the inciting factor. Early surgical debridement with appropriate antibiotics and aggressive supportive care gave good results. PMID:25302233

  10. ENDOSCOPIC SLEEVE GASTROPLASTY FOR OBESITY TREATMENT: TWO YEARS OF EXPERIENCE.

    Science.gov (United States)

    Lopez-Nava, Gontrand; Galvão, M P; Bautista-Castaño, I; Fernandez-Corbelle, J P; Trell, M; Lopez, N

    2017-01-01

    Bariatric endoscopic techniques are minimally invasive and induce gastric volume reduction to treat obesity. Aim : To evaluate endoscopic sleeve gastroplasty (Apollo method) using a suturing method directed at the greater curvature, as well as the perioperative care, two year safety and weight loss. Prospective single-center study over 154 patients (108 females) using the endoscopic sleeve gastroplasty procedure under general anesthesia with overnight inpatient observation. Of the154 initial patients, 143 were available for 1-month of follow-up, 133 for 6-month, 64 for 12-month and 28 completed the 24 month assessment. Follow-up was carried out by a multidisciplinary team (nutritionist and psychologist). Outcomes evaluated were: change in BMI; change in body weight (TBWL); % of loss of initial body weight (%TBWL); % of excess body weight loss (%EWL) (segregated in > or 25% %EWL. There were no mayor adverse events intraprocedure or during the 24 months of follow-up . Endoscopic sleeve gastroplasty with regular monitoring by a multidisciplinary team can be considered an effective, safe and well tolerated procedure for obesity treatment, at least for two years of follow-up. As técnicas de endoscopia bariátrica são minimamente invasivas e induzem à redução do volume gástrico para tratar a obesidade. Avaliar a gastroplastia sleeve endoscópica (método Apollo) usando um método de sutura direcionado para a grande curvatura, bem como os cuidados perioperatórios, segurança em dois anos e perda de peso. Estudo prospectivo em um único centro com 154 pacientes (108 mulheres) usando o procedimento endoscópico de gastroplastia sleeve sob anestesia geral com observação do paciente internado durante a noite. Dos 154 pacientes iniciais, 143 estiveram disponíveis para acompanhamento de um mês, 133 durante seis meses, 64 durante 12 meses e 28 completaram a avaliação de 24 meses. O acompanhamento foi realizado por equipe multidisciplinar (nutricionista e psic

  11. Two Years of Site Diversity Measurements in Guam, USA

    Science.gov (United States)

    Acosta, Roberto J.; Morse, J.; Zemba, M.; Nessel, J.

    2012-01-01

    As NASA communication networks upgrade to higher frequencies, such as Ka-Band, atmospherically induced attenuation can become significant. This attenuation is caused by rain, clouds and atmospheric gases (oxygen and water vapor), with rain having the most noticeable effects. One technique to circumvent the increase in attenuation is to operate two terminals separated by a distance that exceeds the average rain cell size. The fact that rain cells are of finite size can then be exploited by rerouting the signal to the terminal with the strongest link. This technique, known as site diversity, is best suited for climates that have compact (less than 2km) and intense rain cells such as in Guam. In order to study the potential diversity gain at the Tracking and Data Relay Satellite (TDRS) Remote Ground Terminal (GRGT) complex in Guam a site test interferometer (STI) was installed in May of 2010. The STI is composed of two terminals with a 900m baseline that observe the same unmodulated beacon signal broadcast from a geostationary satellite (e.g., UFO 8). The potential site diversity gain is calculated by measuring the difference in signal attenuation seen at each terminal. Over the two years of data collection the cumulative distribution function (CDF) of the site diversity gain shows a better than 3 dB improvement for 90% of the time over standard operation. These results show that the use of site diversity in Guam can be very effective in combating rain fades.

  12. Two Years and Five Images of Supernova Refsdal

    Science.gov (United States)

    Kelly, Patrick

    2017-01-01

    In 1964, Sjur Refsdal hypothesized that a supernova (SN) whose light takes multiple paths to reach us around a strong gravitational lens could be used as a highly powerful probe. For such a system, the time delays between the images of the SN should depend sensitively on the cosmic expansion rate and the distribution of matter within the lens. I will present observations of the first strongly lensed SN resolved into multiple images, which was found in near-infrared imaging taken in early November 2014 with the Hubble Space Telescope (HST). SN `Refsdal' appeared in an Einstein cross configuration around an early-type galaxy in the MACS J1149.6+2223 cluster (z=0.54), and its light curve and spectrum are broadly similar to those of the peculiar and well-studied SN 1987A. Models of the cluster potential predicted that the SN would reappear within two years in a different image of its spiral host galaxy (z=1.49) closer to the cluster's center. In early December 2015, we detected the new image of the SN with the HST, and we anticipate being able to measure its relative time delay with a 1-2% precision, providing a rare test of blind model predictions.

  13. Complications, Reoperations, and Nutrient Deficiencies Two Years after Sleeve Gastrectomy

    Directory of Open Access Journals (Sweden)

    Nicole Pech

    2012-01-01

    Full Text Available Background. The aim of this study was to investigate patient outcomes and nutritional deficiencies following sleeve gastrectomy (SG during a follow-up of two years. Methods. Over a period of 56 months, all consecutive patients who underwent SG were documented in this prospective, single-center, observational study. The study endpoints included operative time, complication rates, nutritional deficiencies and percentage of excess weight loss (%EWL. Results. From September 26, 2005 to May 28, 2009, 82 patients (female : male = 48 : 34 with a mean age of 43.3 years (range: 22–64 and a preoperative BMI of 52.5 kg/m² (range: 36.8–77.0 underwent SG. Major complications were observed in 9.8% of the patients, with 1 death. During follow up 51.2% of patients were supplemented with iron, 36.6% with zinc, 37.8% with calcium, 26.8% with vitamin D, 46.3% with vitamin B12 and 41.5% with folic acid. %EWL was 54.3, 65.3 and 62.6% after 6, 12 and 24 months. Conclusion. SG as a single step procedure is an effective bariatric intervention. Nutritional deficiencies after SG can be detected by routine nutritional screening. Our results show that Vitamin B12 supplementation should suggest routinely after SG.

  14. Persistence of cow's milk allergy beyond two years of age.

    Science.gov (United States)

    Dias, A; Santos, A; Pinheiro, J A

    2010-01-01

    Cow's milk allergy (CMA) epidemiology seems to be changing over time, with an increase in prevalence and persistence. Our aim was to characterise a population of children with CMA beyond two years of age, followed up in a Paediatric Allergy Clinic at the tertiary care level. Retrospective study of children with persistent CMA diagnosed from January 1997 to June 2006. Medical records were analysed regarding: clinical presentation, follow-up, treatment and acquisition of tolerance. Data analysis was performed using Excel 2007 for Windows. Seventy-nine children were included, with mean age at first symptoms of 3 months. The symptoms were immediate in 93%, with cutaneous (87.3%), gastrointestinal (55.7%) and respiratory (25.3%) manifestations. During the follow-up period, 30% developed atopic eczema, 52% asthma and 35% rhinoconjunctivitis. A family history of atopy was identified in 53%. The majority presented increased serum total IgE (376+/-723 KU/l) and positive skin prick test (SPT) to cow's milk (CM) (79%). SPT to goat's milk was positive in 2/3 of cases. Fifty-five percent had at least one accidental exposure to CM (severe reactions in 6%). During CM elimination diet, 35% were initially given an extensively hydrolysed formula, 17% a soy formula, and 48% both. By the age of 10 years, 44% of children persisted with CMA. Our population of CM allergic children presented immediate symptoms with cutaneous expression in the majority. Severe reactions were common on accidental exposure. By the age of 10 years, 44% maintained CMA, highlighting the importance of a multidisciplinary follow-up. Copyright 2009 SEICAP. Published by Elsevier Espana. All rights reserved.

  15. Two-year outcomes of transforaminal lumbar interbody fusion.

    Science.gov (United States)

    Poh, Seng Yew; Yue, Wai Mun; Chen, Li-Tat John; Guo, Chang-Ming; Yeo, William; Tan, Seang-Beng

    2011-08-01

    To evaluate the outcomes, fusion rates, complications, and adjacent segment degeneration associated with transforaminal lumbar interbody fusion (TLIF). 32 men and 80 women aged 15 to 85 (mean, 57) years underwent 141 fusions (84 one-level, 27 2-level, and one 3-level) and were followed up for 24 to 76 (mean, 33) months. 92% of the patients had degenerative lumbar disease, 15 of whom had had previous lumbar surgery. Radiographic and clinical outcomes were assessed at 2 years. The short-form 36 (SF-36) health survey, visual analogue scale (VAS) for pain, and the modified North American Spine Society (NASS) Low Back Pain Outcome Instrument were used. Of the 141 levels fused, 110 (78%) were fused with remodelling and trabeculae (grade I), and 31 (22%) had intact grafts but were not fully incorporated (grade II). No patient had pseudoarthroses (grade III or IV). For one-level fusions, poorer radiological fusion grades correlated with higher VAS scores for pain (p<0.01). All components of the SF-36, the VAS scores for pain, and the NASS scores improved significantly after TLIF (p<0.01), except for general health in the SF-36 (p=0.59). Improvement from postoperative 6 months to 2 years was not significant, except for physical function (p<0.01) and role function (physical) [p=0.01] in the SF-36. Two years after TLIF, 50% of the patients reported returning to full function, whereas 72% were satisfied. 26 (23%) of the patients had adjacent segment degeneration, but only 4 of them were symptomatic. TLIF is a safe and effective treatment for degenerative lumbar diseases.

  16. Complications and nutrient deficiencies two years after sleeve gastrectomy

    Directory of Open Access Journals (Sweden)

    Pech Nicole

    2012-07-01

    Full Text Available Abstract Background The aim of this systematic study was to investigate patient outcomes and nutritional deficiencies following sleeve gastrectomy (SG during a median follow-up of two years. Methods Over a period of 56 months, all consecutive patients who underwent SG were documented in this prospective, single-center, observational study. The study endpoints included complication rates, nutritional deficiencies and percentage of excess weight loss (%EWL. Results From September 26, 2005 to May 28, 2009, 100 patients (female: male = 59:41 with a mean age of 43.6 years (range: 22–64 and a preoperative BMI of 52.3 kg/² (range: 36–77 underwent SG. The mean operative time was 86.4 min (range: 35–275. Major complications were observed in 8.0 % of the patients. During the follow-up period, 25 patients (25.0 % underwent a second bariatric intervention (22 DS and 3 RYGBP. Out of the total 100 patients, 48 % were supplemented with iron, 33 % with zinc, 34 % with a combination of calcium carbonate and cholecalciferol, 24 % with vitamin D, 42 % with vitamin B12 and 40 % with folic acid. The patients who received only a SG (n = 75 had %EWL of 53.6, 65.8 and 62.6 % after 6, 12 and 24 months, respectively. Conclusions SG is a highly effective bariatric intervention for morbidly obese patients. Nutritional deficiencies resulting from the procedure can be detected by routine nutritional screening. Results of the study show that Vitamin B12 supplementation should suggested routinely.

  17. Pedicle screw-rod fixation : a feasible treatment for dogs with severe degenerative lumbosacral stenosis

    NARCIS (Netherlands)

    Tellegen, Anna R; Willems, Nicole; Tryfonidou, Marianna A; Meij, Björn P

    2015-01-01

    BACKGROUND: Degenerative lumbosacral stenosis is a common problem in large breed dogs. For severe degenerative lumbosacral stenosis, conservative treatment is often not effective and surgical intervention remains as the last treatment option. The objective of this retrospective study was to assess

  18. Number of Physics Faculty in Two-Year Colleges: Results from the 2012 Survey of Physics in Two-Year Colleges. Focus On

    Science.gov (United States)

    White, Susan; Chu, Raymond

    2013-01-01

    In an earlier report, ("Physics Enrollments in Two-Year Colleges," ED547610), Susan White and Raymond Chu examined physics enrollments--both the number of students and the types of classes taught--at the 1,063 two-year college campuses in the US where they believe physics is offered. This "Focus On" considers the faculty…

  19. Reliability of computer designed surgical guides in six implant rehabilitations with two years follow-up.

    Science.gov (United States)

    Giordano, Mauro; Ausiello, Pietro; Martorelli, Massimo; Sorrentino, Roberto

    2012-09-01

    To evaluate the reliability and accuracy of computer-designed surgical guides in osseointegrated oral implant rehabilitation. Six implant rehabilitations, with a total of 17 implants, were completed with computer-designed surgical guides, performed with the master model developed by muco-compressive and muco-static impressions. In the first case, the surgical guide had exclusively mucosal support, in the second case exclusively dental support. For all six cases computer-aided surgical planning was performed by virtual analyses with 3D models obtained by dental scan DICOM data. The accuracy and stability of implant osseointegration over two years post surgery was then evaluated with clinical and radiographic examinations. Radiographic examination, performed with digital acquisitions (RVG - Radio Video graph) and parallel techniques, allowed two-dimensional feedback with a margin of linear error of 10%. Implant osseointegration was recorded for all the examined rehabilitations. During the clinical and radiographic post-surgical assessments, over the following two years, the peri-implant bone level was found to be stable and without appearance of any complications. The margin of error recorded between pre-operative positions assigned by virtual analysis and the post-surgical digital radiographic observations was as low as 0.2mm. Computer-guided implant surgery can be very effective in oral rehabilitations, providing an opportunity for the surgeon: (a) to avoid the necessity of muco-periosteal detachments and then (b) to perform minimally invasive interventions, whenever appropriate, with a flapless approach. Copyright © 2012 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  20. Results of a two-year quality control program for a helical tomotherapy unit

    International Nuclear Information System (INIS)

    Broggi, Sara; Mauro Cattaneo, Giovanni; Molinelli, Silvia; Maggiulli, Eleonora; Del Vecchio, Antonella; Longobardi, Barbara; Perna, Lucia; Fazio, Ferruccio; Calandrino, Riccardo

    2008-01-01

    Background and purpose: Image-guided helical tomotherapy (HT) is a new modality for delivering intensity modulated radiation therapy (IMRT) with helical irradiation: the slip ring continuously rotates while the couch moves into the bore. The radiation source (Linac, 6 MV) is collimated into a fan beam and modulated by means of a binary multileaf collimator (MLC). A xenon detector array, opposite the radiation source, allows a megavoltage-CT (MVCT) acquisition of patient images for set-up verification. The aim of this paper is to report the results of a two-year quality control (QC) program for the physical and dosimetric characterization of an HT unit installed at our Institute and clinically activated in November 2004, in order to monitor and verify the stability and the reliability of this promising radiation treatment unit. Materials and methods: Conventional Linac acceptance protocols (ATP) and QC protocols were adapted to HT with the addition of specific items reflecting important differences between the two irradiation modalities. QC tests can be summarized as: (a) mechanical and geometrical characterization of the system's components: evaluation of alignment among radiation source-gantry rotation plan-jaws-MLC-MVCT; (b) treatment beam configuration in static condition: depth dose curves (PDD) and profiles, output factors, output reproducibility and linearity; (c) dynamic component characterization: accuracy and reproducibility of MLC positioning; rotational output reproducibility and linearity, leaf latency, couch movement constancy; (d) gantry-couch and MLC-gantry synchronization; and (e) MVCT image quality. Peculiar periodicity specific tolerance and action levels were defined. Ionization chambers (Exradin A1SL 0.056 cc), films (XOmat-V/EDR2), water and solid water phantoms were used to perform quality assurance measurements. Results: Over a two-year period the final average output variation after possible beam output adjustment was -0.2 ± 1% for the

  1. Physics Enrollments in Two-Year Colleges: Results from the 2012 Survey of Physics in Two-Year Colleges. Focus On

    Science.gov (United States)

    White, Susan; Chu, Raymond

    2013-01-01

    This "Focus On" first considers the role two-year colleges (TYCs) play in post-secondary physics education. In their 2007 Survey of Undergraduate Seniors in degree-granting physics departments, the authors asked students if they had begun their post-secondary education at a TYC. Nine percent of the physics undergraduate seniors in 2007…

  2. Topography and Reflectance of Mercury After Two Years of Laser Altimetry

    Science.gov (United States)

    Neumann, G. A.; Sun, X.; Mazarico, E.; Smith, D. E.; Zuber, M. T.; Ernst, C. M.; Barnouin, O. S.; Chabot, N. L.; Paige, D. A.; Solomon, S. C.

    2013-12-01

    The Mercury Laser Altimeter (MLA) on the MESSENGER spacecraft has been ranging to the planet Mercury since March 2011, first in a 12-h, 83.5°-inclination orbit, and currently in an 8-h orbit. The orbital periapsis latitude, initially at 60°N, moved slowly northward during the first two years of the orbital mission, enabling near-complete coverage of the northern hemisphere with ~15 million measured radii. Targeted observations during the first extended mission allowed mapping of nearly all regions of extensive shadow within northern high-latitude craters. The refined topography provides a comprehensive dataset for geological studies, illumination and thermal modeling, and studies of the interior. The strength of laser returns in relation to the 10-20 mJ energy of the outgoing laser pulses has provided ~8.7 million active measurements of surface reflectance. Initial results, in conjunction with neutron spectrometry and Earth-based radar, confirmed the existence of water ice exposed at the surface within the deepest shadows of Prokofiev Crater at 85° N and other regions of high radar cross-section, as well as darker volatile species that provide an insulating surficial layer for most radar-bright polar deposits. Refined measurements of reflectance, corroborated by imaging of shadowed regions illuminated by scattered light, reveal the areal extent of polar deposits. These deposits expose water ice at the surface only in limited regions where surface temperatures are predicted never to exceed the long-term stability limit of water ice, whereas subsurface temperatures in other areas of permanent shadow predict the long-term preservation of more extensive deposits of water ice and other volatiles if that material is overlain by an insulating layer.

  3. The Ties That Bind: Linkages among Secondary Schools, Two-Year Colleges, and Baccalaureate Institutions.

    Science.gov (United States)

    Lorence, James J.

    This document discusses the roles of secondary schools, two-year colleges, and the upper level university in the University of Wisconsin System. Because of close ties with the host communities, Wisconsin's two-year institutions are uniquely situated to function as community resources. The paper discusses the advantages of a collaborative…

  4. A Framework and Strategies for Advancing Change and Innovation in Two-Year Colleges

    Science.gov (United States)

    Matheny, Christopher J.; Conrad, Clifton

    2012-01-01

    Notwithstanding variation in institutional missions, two-year colleges are the gateway to postsecondary education for the majority of college and university students in this country. As institutions of choice for many and institutions of necessity for others, two-year institutions are constantly challenged to meet the rapidly changing needs of…

  5. Two-year survival of glass ionomer sealanTs placed as parT of ...

    African Journals Online (AJOL)

    2010-09-09

    Sep 9, 2010 ... Two-year survival of glass ionomer sealanTs placed as parT of proximal aTraumaTic. resToraTive ... absTracT. Objective: To evaluate after two years, the survival rate of glass ionomer cement (gic) ... or symptoms of periodontal disease, and clinically the ..... saliva contamination on the bond of dentine resin-.

  6. Factors Influencing Japanese Women to Choose Two-Year Colleges in Japan

    Science.gov (United States)

    Anzai, Shinobu; Paik, Chie Matsuzawa

    2012-01-01

    Two-year colleges in Japan have traditionally absorbed the major portion of female college entrants due to long-held gender stereotypes. Recently, Japanese women began to explore selfhood outside the traditional realm of marriage and motherhood. However, two-year colleges in Japan today continue to enroll mostly female students and few male…

  7. Administrative Governance and Mission of Two Year Colleges within Universities. SACE Research Report #14.

    Science.gov (United States)

    Dunlap, William S.

    It is estimated that over 200 two-year colleges exist within universities in the United States. In April 1987, at the annual meeting of the American Association of Community and Junior Colleges, the Council of Two Year Colleges within Universities was formed to better represent the issues and concerns unique to these academic institutions. In…

  8. Reliability of Serum Metabolites over a Two-Year Period : A Targeted Metabolomic Approach in Fasting and Non-Fasting Samples from EPIC

    NARCIS (Netherlands)

    Carayol, Marion; Licaj, Idlir; Achaintre, David; Sacerdote, Carlotta; Vineis, Paolo; Key, Timothy J; Onland Moret, N Charlotte; Scalbert, Augustin; Rinaldi, Sabina; Ferrari, Pietro

    2015-01-01

    OBJECTIVE: Although metabolic profiles have been associated with chronic disease risk, lack of temporal stability of metabolite levels could limit their use in epidemiological investigations. The present study aims to evaluate the reliability over a two-year period of 158 metabolites and compare

  9. Quasi-two-year cycle in indices of geomagnetic and solar activity

    International Nuclear Information System (INIS)

    Nuzhdina, M.A.

    1986-01-01

    The spectral, amplitude and phase analysis of monthly standardized anomalies in the indices of planetary geomagnetic disturbance and Wolf numbers for the 100-year period and 18-year time ranges are carried out. There is a weak correlation between the monthly anomalies of fluctuations of the Wolf numbers and planetary indices of geomagnetic distubance manifesting quasi-two-year cyclic recurrence. There is the quasi-two-year cycle of 26 months average duration in the indices of geomagnetic disturbance and Wolf numbers. The quasi-two-year cycle is a rather wide band with the oscillation periods of 21 to 29 months having different amplitudes and phases. The quasi-two-year cycle in geomagnetism and the Wolf numbers is unstable: for 100 years of observations its components change in amplitude and phase

  10. Prevalence of oral mucosal lesions from birth to two years | Yilmaz ...

    African Journals Online (AJOL)

    Materials and Methods: A total of 299 infants from newborn to two years of ... dermatological disease in infants, which affects the oral feeding of the infants. Routine examination of the oral mucosa should be a part of the pediatric examination.

  11. Study on Growth Rhythm of Juveniles Cistolemmys Flavomarginata for One and Two Years Old

    Science.gov (United States)

    Huang, Bin

    Growth of one and two year old Cistolemmys flavomarginata is studied. In natural temperature and under artificial feeding condition, juvenile turtles grow for 180 days in Xinyang, one year old turtle average body weight increased from 18.1 g to 54.5 g, the relative growth rate is 204.1%, the absolute growth rate is 0.21. two year old turtle average body weight increased from 46.8 g to 101.1 g, the relative growth rate is 115.98%, the absolute growth rate is 0.30. But two year old turtle growth rate is slower than that of one year old turtle. The body weight, carapace length, carapace width, plastron length, plastron width and carapace high are correlated positively to daily age. The body weight growth equations of one and two year old turtles are deduced. Compared with other reptiles, whole growth cycle is grasped systemically by the growth patterns.

  12. Revising the ACS Guidelines for Chemistry Programs in Two-Year Colleges: Shaping the Next Edition

    Science.gov (United States)

    Clevenger, John V.; Wesemann, Jodi L.

    2008-06-01

    Much has changed since the second edition of the ACS Guidelines for Chemistry Programs in Two-Year Colleges was prepared in 1997. The roles that two-year college programs can and do play in providing access to and success in higher education are receiving more attention. Increased knowledge on how people learn, advances in technology, and demands for accountability are changing the educational landscape.

  13. Infant diet, gender and the development of vagal tone stability during the first two years of life

    Science.gov (United States)

    Postnatal nutrition influences neurodevelopment, including autonomic nervous system components associated with cardiac control. In this study resting vagal tone (V) was measured quarterly during infancy and at 2 years in 146 breast-fed, 143 milk formula-fed, and 137 soy formula-fed infants. Stabilit...

  14. Two-year trajectory of fall risk in people with Parkinson’s disease: a latent class analysis

    Science.gov (United States)

    Paul, Serene S; Thackeray, Anne; Duncan, Ryan P; Cavanaugh, James T; Ellis, Theresa D; Earhart, Gammon M; Ford, Matthew P; Foreman, K Bo; Dibble, Leland E

    2015-01-01

    Objective To examine fall risk trajectories occurring naturally in a sample of individuals with early to middle stage Parkinson’s disease (PD). Design Latent class analysis, specifically growth mixture modeling (GMM) of longitudinal fall risk trajectories. Setting Not applicable. Participants 230 community-dwelling PD participants of a longitudinal cohort study who attended at least two of five assessments over a two year period. Interventions Not applicable. Main Outcome Measures Fall risk trajectory (low, medium or high risk) and stability of fall risk trajectory (stable or fluctuating). Fall risk was determined at 6-monthly intervals using a simple clinical tool based on fall history, freezing of gait, and gait speed. Results The GMM optimally grouped participants into three fall risk trajectories that closely mirrored baseline fall risk status (p=.001). The high fall risk trajectory was most common (42.6%) and included participants with longer and more severe disease and with higher postural instability and gait disability (PIGD) scores than the low and medium risk trajectories (pfall risk (posterior probability fall risk trajectories over two years. Further investigation is required to determine whether interventions to improve gait and balance may improve fall risk trajectories in people with PD. PMID:26606871

  15. A statewide consortium's adoption of a unified nursing curriculum: evaluation of the first two years.

    Science.gov (United States)

    Tse, Alice M; Niederhauser, Victoria; Steffen, John J; Magnussen, Lois; Morrisette, Nova; Polokoff, Rachael; Chock, Johnelle

    2014-01-01

    This article provides an evaluation of the first two years of implementation of a statewide nursing consortium (SNC) curriculum on nursing faculty work life, teaching productivity, and quality of education. In response to the call for nursing education reform, the SNC incorporated new approaches to competency-based, student-centered learning and clinical education. Faculty and two cohorts of students were measured at three points over the first two years of the curriculum implementation. The expected positive impact of the SNC was documented at the start of the first year, but not sustained. Students reported having more confidence in their clinical skills at the start of the first year, yet demonstrated significantly less confidence in their ability after two years. Faculty indicated that the SNC allowed greater opportunity for collaboration, but that the experience did not alter their classroom performance or satisfaction beyond the first year.

  16. Boys starting school disadvantaged: implications from teachers' ratings of behaviour and achievement in the first two years.

    Science.gov (United States)

    Childs, G; McKay, M

    2001-06-01

    Consistent evidence indicates that low socio-economic status (SES) acts as an important stressor and vulnerability factor for children's school learning. However, specific mechanism(s) of this process are still not well understood. This study was a follow-up of the classroom learning behaviour and perceived achievement of low and middle income children after two years at school, who had previously been rated soon after starting school. It examined whether teachers' ratings displayed predictive stability over that period, and whether significant differences evident at age 5 in SES and gender were still operative at age 7. Two samples, of low income (N = 85) and middle income (N = 63) children, were rated following school entry (mean age 5 years 3 months) and rated again after two years at school. The children were rated at both points by their regular classroom teachers using the Learning Behaviours Scale (Stott et al., 1998) with subscales of Distractible, Apprehensive and Uncooperative, together with ratings of academic achievement and their personal perception of each child. SES was found to be a very limited predictor for the learning behaviour subscale ratings and for teachers' personal perceptions at both ages 5 and 7. SES did significantly predict expected Academic Achievement at age 5, but this effect disappeared completely by age 7. Conversely, within the two defined groups, Low Income boys were found to display significantly poorer learning behaviours at age 5, especially in terms of distractible behaviour, compared with Middle Income boys and with girls generally. This pattern was maintained over the next two years of their schooling. The effect of SES was thus demonstrated more powerfully in between-group differences than by means of regression. The findings emphasised the persistence of teachers' initial negative impressions about distractible 'hard to manage' boys from low SES families. The outcomes of this study suggest that low SES boys commenced

  17. Transaldolase deficiency in a two-year-old boy with cirrhosis

    NARCIS (Netherlands)

    Wamelink, M.M.; Struijs, E.A.; Salomons, G.S.; Fowler, D.; Jakobs, C.A.J.M.; Clayton, P.T.

    2008-01-01

    Transaldolase (TALDO) deficiency is a rare inborn error of the pentose phosphate pathway. We report the clinical presentation and laboratory findings of a new patient with TALDO deficiency. The two-year-old Arabic boy presented with neonatal onset of anemia and thrombocytopenia, tubulopathy, and

  18. The Fermi GBM Gamma-Ray Burst Catalog: The First Two Years

    NARCIS (Netherlands)

    Paciesas, W.S.; Meegan, C.A.; von Kienlin, A.; Bhat, P.N.; Bissaldi, E.; Briggs, M.S.; M. Burgess, J.; Chaplin, V.; Connaughton, V.; Diehl, R.; Fishman, G.J.; Fitzpatrick, G.; Foley, S.; H. Gibby, M.; Giles, M.; Goldstein, A.; Greiner, J.; Gruber, D.; Guiriec, S.; van der Horst, A.J.; Kippen, R.M.; Kouveliotou, C.; Lichti, G.; Lin, L.; McBreen, S.; Preece, R.D.; Rau, A.; Tierney, D.; Wilson-Hodge, C.

    2012-01-01

    The Fermi Gamma-ray Burst Monitor (GBM) is designed to enhance the scientific return from Fermi in studying gamma-ray bursts (GRBs). In its first two years of operation GBM triggered on 491 GRBs. We summarize the criteria used for triggering and quantify the general characteristics of the triggered

  19. Bypass iliac-mesenteric-cava inpatients under two years of age. Case report and literature review

    Directory of Open Access Journals (Sweden)

    Villanueva López Noé

    2014-07-01

    Full Text Available Introduction: In the treatment of portal hypertension in pediatric patients, some type of porto-systemic shunt is indicated, which is an unusual surgical procedure in patients under two years of age, due to the low incidence of this disease at this age and the increase in the number of complications. Objective: We present our experience and results with this procedure in patients under two years of age seen in the Hepatobiliopancreatic general surgery service at Instituto Nacional de PediatríaDiscussion: The causes of portal hypertension in children are varied. Among the extrahepatic causes, the most common is cavernomatous portal degeneration. Children with portal hypertension under two years have severe symptoms such as recurrent gastrointestinal bleeding or anemia; others have hypersplenism data. In many cases medical management is useless and a surgical procedure require such as a portosystemic shunt in order to decrease the size of varicose esophageal veins and prevent bleeding that threatens the patient’s life. Conclusion: The iliac-mesenteric-caval shunt in patients under two years is a feasible alternative that improves the clinical status of the patient, reducing the risk of bleeding. However long-term studies are needed to determine the outcome of these patients. Keywords: Iliac-mesenteric-caval shunt, portal hypertension.

  20. Assessing the nutritional information for children younger than two years old available on popular websites

    Directory of Open Access Journals (Sweden)

    Gisele da Silva Gomes Monteiro

    Full Text Available Abstract Objective: To analyze whether the information found on popular Internet sites are in accordance with the steps recommended by the Food Guide for Children Younger than Two Years of the Ministry of Health (2010. Methods: Descriptive/comparative study, carried out between August and October 2014, which carried out a search for popular sites (for lay people in Portuguese, containing information on nutrition of children younger than two years. The Google search engine was used. These findings were compared with the Food Guide for Children Younger than Two Years of the Ministry of Health (2010. It was verified whether the information shown on the websites was in accordance with the Guide. Results: A total of 50 sites were analyzed, including blogs, food company websites and websites specialized in child nutrition. Only 10% of those pages correctly showed every step of the Food Guide. The recommendations were: exclusive breastfeeding up to six months of life (80%; complementary feeding from six months of life (36%; baby food consistency according to the guide (48%; encouraging the consumption of fruits and vegetables daily (60%. Regarding the complementary feeding safety and hygiene, 26% contained correct information. Only 36% correctly warned about which foods should be avoided in the first years of life. Conclusions: The information found on the sites is largely in disagreement with the Ministry of Health recommendations, which can lead to misconceptions in the nutritional care of the children younger than two years.

  1. Where to Attend? Estimating the Effects of Beginning College at a Two-Year Institution

    Science.gov (United States)

    Reynolds, C. Lockwood

    2012-01-01

    Two-year colleges are an important part of the higher education system in the United States but there are concerns as to how attendance at these institutions affects educational attainment and labor market outcomes. This paper uses data from a nationally representative survey to examine the impact of students beginning their college career at a…

  2. Evolution of Costs of Inflammatory Bowel Disease over Two Years of Follow-Up

    NARCIS (Netherlands)

    Valk, M. van der; Mangen, M.J.; Severs, M.; Have, M. van der; Dijkstra, G.; Bodegraven, A.A. van; Fidder, H.H.; Jong, D.J. de; Woude, C.J. van der; Romberg-Camps, M.J.; Clemens, C.H.; Jansen, J.M.; Meeberg, P.C. van de; Mahmmod, N.; Meulen-de Jong, A.E. van der; Ponsioen, C.Y.; Bolwerk, C.; Vermeijden, J.R.; Siersema, P.D.; Leenders, M.; Oldenburg, B.

    2016-01-01

    BACKGROUND: With the increasing use of anti-TNF therapy in inflammatory bowel disease (IBD), a shift of costs has been observed with medication costs replacing hospitalization and surgery as major cost driver. We aimed to explore the evolution of IBD-related costs over two years of follow-up.

  3. Evolution of Costs of Inflammatory Bowel Disease over Two Years of Follow-Up

    NARCIS (Netherlands)

    van der Valk, Mirthe E.; Mangen, Marie-Josee J.; Severs, Mirjam; van der Have, Mike; Dijkstra, Gerard; van Bodegraven, Ad A.; Fidder, Herma H.; de Jong, Dirk J.; van der Woude, C. Janneke; Romberg-Camps, Marielle J. L.; Clemens, Cees H. M.; Jansen, Jeroen M.; de Meeberg, Paul C. van; Mahmmod, Nofel; van der Meulen-de Jong, Andrea E.; Ponsioen, Cyriel Y.; Bolwerk, Clemens; Vermeijden, J. Reinoud; Siersema, Peter D.; Leenders, Max; Oldenburg, Bas

    2016-01-01

    Background With the increasing use of anti-TNF therapy in inflammatory bowel disease (IBD), a shift of costs has been observed with medication costs replacing hospitalization and surgery as major cost driver. We aimed to explore the evolution of IBD-related costs over two years of follow-up. Methods

  4. Evolution of Costs of Inflammatory Bowel Disease over Two Years of Follow-Up

    NARCIS (Netherlands)

    van der Valk, Mirthe E.; Mangen, Marie-Josée J.; Severs, Mirjam; van der Have, Mike; Dijkstra, Gerard; van Bodegraven, Ad A.; Fidder, Herma H.; de Jong, Dirk J.; van der Woude, C. Janneke; Romberg-Camps, Mariëlle J. L.; Clemens, Cees H. M.; Jansen, Jeroen M.; van de Meeberg, Paul C.; Mahmmod, Nofel; van der Meulen-de Jong, Andrea E.; Ponsioen, Cyriel Y.; Bolwerk, Clemens; Vermeijden, J. Reinoud; Siersema, Peter D.; Leenders, Max; Oldenburg, Bas

    2016-01-01

    With the increasing use of anti-TNF therapy in inflammatory bowel disease (IBD), a shift of costs has been observed with medication costs replacing hospitalization and surgery as major cost driver. We aimed to explore the evolution of IBD-related costs over two years of follow-up. In total 1,307

  5. Evolution of costs of inflammatory bowel disease over two years of follow-up

    NARCIS (Netherlands)

    M.E. van der Valk (Mirthe); M.J.J. Mangen; M. Severs; M. van der Have (Mike); G. Dijkstra (Gerard); A.A. van Bodegraven (Ad); M. Fidder (Melissa); D.J. De Jong (Dirk J.); C.J. van der Woude (Janneke); M. Romberg-Camps (Mariëlle); P.R. Clemens (Paula ); J.M. Jansen (Jeroen); P.C. van de Meeberg (Paul); N. Mahmmod (Nofel); A.E. van der Meulen-de Jong (Andrea); C.Y. Ponsioen (Cyril); C.L. Bolwerk (Clemens); J.R. Vermeijden (J. Reinoud); P.D. Siersema (Peter); M. Leenders (Max); B. Oldenburg (Bas)

    2016-01-01

    textabstractBackground: With the increasing use of anti-TNF therapy in inflammatory bowel disease (IBD), a shift of costs has been observed with medication costs replacing hospitalization and surgery as major cost driver. We aimed to explore the evolution of IBD-related costs over two years of

  6. Determining the Numeracy and Algebra Errors of Students in a Two-Year Vocational School

    Science.gov (United States)

    Akyüz, Gözde

    2015-01-01

    The goal of this study was to determine the mathematics achievement level in basic numeracy and algebra concepts of students in a two-year program in a technical vocational school of higher education and determine the errors that they make in these topics. The researcher developed a diagnostic mathematics achievement test related to numeracy and…

  7. Old Premises and Old Promises: Contemporary Critical Theory and Teaching at the Two-Year College.

    Science.gov (United States)

    Will, Norman P.

    One composition teacher's experiences with the pluralistic student body of a two-year college led him to question the value of higher education, in particular writing and literature. Most current literature teachers were trained in the principles and methods of New Criticism, and most have found that these approaches are not adequate for their…

  8. Hydroxychloroquine treatment for primary Sjögren's syndrome: a two year double blind crossover trial

    NARCIS (Netherlands)

    Kruize, A. A.; Hené, R. J.; Kallenberg, C. G.; van Bijsterveld, O. P.; van der Heide, A.; Kater, L.; Bijlsma, J. W.

    1993-01-01

    In 1985 and 1988 a positive effect of treatment of primary Sjögren's syndrome with hydroxychloroquine was reported in two small open studies. To investigate further the clinical and laboratory effects of hydroxychloroquine in primary Sjögren's syndrome a two year study was performed. The design of

  9. Interview with Brian Kotz: Data Science at Two-Year Colleges

    Science.gov (United States)

    Rossman, Allan; Kotz, Brian

    2018-01-01

    Brian Kotz is Professor of Mathematics and Statistics at Montgomery College. He is a former member of the American Statistical Association/American Mathematical Association of Two-Year Colleges (ASA)/(AMATYC) Joint Committee and the current chair of the AMATYC Data Science Subcommittee. This interview took place via email on November 23,…

  10. A Survey of Speech Education in United States Two-Year Colleges.

    Science.gov (United States)

    Planck, Carolyn Roberts

    The status of speech education in all United States two-year colleges is discussed. Both public and private schools are examined. Two separate studies were conducted, each utilizing the same procedure. The specific aspects with which the research was concerned were: (1) availability of speech courses, (2) departmentalization of speech courses, (3)…

  11. Two-year results of femtosecond assisted LASIK versus PRK for different severity of astigmatism

    Directory of Open Access Journals (Sweden)

    Mohammad Miraftab

    2018-03-01

    Conclusions: Our results pointed to better two-year results with femto-LASIK in the treatment of different degrees of astigmatism. UDVA improvement was superior with femto-LASIK, but the two methods did not significantly differ in terms of CDVA improvement.

  12. Aetiological Agents of Ear Discharge: A Two year Review in a ...

    African Journals Online (AJOL)

    Journal Home > Vol 48, No 2 (2014) > ... Methodology: This was a retrospective review of laboratory records of all ear swabs submitted for culture over a two year ... Data was obtained on demographic characteristics of patients, clinical ... of the discharging ear was Pseudomonas spp followed by Staphylococcus aureus.

  13. Two Years into the Journey: AACSB Assessment of Learning in a "Principles of Marketing" Course

    Science.gov (United States)

    Clinton, Steven R.; Marco, Gayle; Chu, Yun

    2009-01-01

    Using a "Principles of Marketing" course, the authors demonstrate how compliance with AACSB standards and assessment of learning has been undertaken at Robert Morris University over a two-year period. Learning goals and objectives are tied to a specific assessment instrument to provide an illustration of how broad conceptual ideas are…

  14. Institutional Researchers' Use of Qualitative Research Methods for Institutional Accountability at Two Year Colleges in Texas

    Science.gov (United States)

    Sethna, Bishar M.

    2011-01-01

    This study examined institutional researchers' use of qualitative methods to document institutional accountability and effectiveness at two-year colleges in Texas. Participants were Institutional Research and Effectiveness personnel. Data were collected through a survey consisting of closed and open ended questions which was administered…

  15. Provision of Educational Supports to Students with Disabilities in Two-year Postsecondary Programs.

    Science.gov (United States)

    Black, Rhonda; Smith, Garnett; Harding, Tom; Stodden, Rboert A.

    2002-01-01

    A national survey of support services for students with disabilities in postsecondary institutions (n=650; 43% response) found that, despite legislative mandates, provision of accommodations, advocacy, remedial assistance, college-adjustment assistance, and career-related supports varies widely. The level of services in two-year and four-year…

  16. Where the Italian Journal of Public Health is going? A tale of the last two years

    Directory of Open Access Journals (Sweden)

    Giuseppe La Torre

    2011-03-01

    Full Text Available

    Extract:

    Two years ago, speaking about the future of the Italian Journal of Public Health, we told that the reason why the journal is also an international journal (almost 40% of published papers come from outside Italy is “mainly due to our membership to EUPHA and to several scientific network”.

  17. A Call for Strategic Planning: The Two-Year College Imperative.

    Science.gov (United States)

    Masoner, David J.; Essex, Nathan, L.

    1987-01-01

    Addresses the imperative for strategic and tactical planning to support the viability of the two-year college. Describes a process for approaching strategic planning, comprising the following steps: self-identification, self-analysis, analysis of service area, informed decision making, and the development of a marketing plan. (CBC)

  18. Changing Autoerotic Attitudes and Practices among College Females: A Two-Year Follow-Up Study.

    Science.gov (United States)

    Davidson, J. Kenneth, Sr.; Darling, Carol A.

    1988-01-01

    Examined effects of functional marriage and family course on female undergraduates' masturbatory attitudes and behaviors. Subjects completed questionnaires during course and two years later. Control group also completed questionnaires. Course respondents became substantially more accepting of masturbation by acquaintances and were more likely to…

  19. Omphalocele: from diagnosis to growth and development at two years of age

    NARCIS (Netherlands)

    A. Hijkoop (Annelieke); N.C.J. Peters (Nina); R.L. Lechner (Rosan); Y. van Bever (Yolande); A.P.J.M. van Gils-Frijters (Annabel); D. Tibboel (Dick); R.M.H. Wijnen (René); T.E. Cohen-Overbeek (Titia); H. IJsselstijn (Hanneke)

    2018-01-01

    markdownabstract__Objective__ To compare the prenatal frame of reference of omphalocele (i.e. survival of fetuses) with that after birth (i.e. survival of liveborn neonates), and to assess physical growth and neurodevelopment in children with minor or giant omphalocele up to two years of age.

  20. Two-Year-Old Children Differentiate Test Questions from Genuine Questions

    Science.gov (United States)

    Grosse, Gerlind; Tomasello, Michael

    2012-01-01

    Children are frequently confronted with so-called "test questions". While genuine questions are requests for missing information, test questions ask for information obviously already known to the questioner. In this study we explored whether two-year-old children respond differentially to one and the same question used as either a genuine question…

  1. Cognitive performance of detoxified alcoholic Korsakoff syndrome patients remains stable over two years.

    Science.gov (United States)

    Fujiwara, Esther; Brand, Matthias; Borsutzky, Sabine; Steingass, Hans-P; Markowitsch, Hans J

    2008-07-01

    Excessive alcohol consumption is assumed to promote cognitive decline, eventually increasing the risk of dementia. However, little is known about the time course of cognitive functions in patients with chronic alcoholic Korsakoff syndrome (KS). Therefore, we assessed neuropsychological performance in 20 detoxified chronic KS inpatients at time 1 (T1) with a follow-up after two years (T2). The neuropsychological tests assessed verbal and visual short- and long-term memory, working memory, basic executive functions, language, general knowledge, and visual-spatial abilities. Surveys with caregivers and medical records provided information about current and previous disease-related parameters, drinking history, additional pathologies, as well as psychosocial and cognitive therapy within the two-year period. At both sessions, the majority of the KS patients' results were inferior to those of normal subjects. Comparing T1 and T2 revealed no significant decline in any of the investigated functions. Instead, general knowledge, visual long-term memory, and verbal fluency improved slightly after two years, though they still remained within pathological range. Comparing most improved and most deteriorated patients, better outcome occurred more frequently in men than women and was associated with higher premorbid education and fewer detoxifications in the past. In this sample of detoxified KS patients there was no indication of accelerated cognitive decline or onset of dementia-like symptoms over two years.

  2. Academic Life at the Franchise: Faculty Culture in a Rural Two-Year Branch Campus.

    Science.gov (United States)

    Wolfe, John R.; Strange, C. Carney

    2003-01-01

    This case study of faculty culture focused on the dynamics of a small, rural, two-year branch campus of a large state university. It reports descriptive themes concerning the isolation and rural location of the campus, its diminutive size, faculty role perspectives, and factors related to faculty role implementation. It provides a portrait of this…

  3. A Data-Driven Approach to SEM Development at a Two-Year College

    Science.gov (United States)

    Pirius, Landon K.

    2014-01-01

    This article explores implementation of strategic enrollment management (SEM) at a two-year college and why SEM is critical to the long-term viability of an institution. This article also outlines the five initial steps needed to implement SEM, including identifying SEM leadership, building a SEM committee, developing a common understanding of…

  4. Two-year survival of glass ionomer sealants placed as part of ...

    African Journals Online (AJOL)

    , ... Results: The two-year cumulative survival of the sealants was 10.9%, and the survival of the sealants was not significantly affected by the GIC material brand and the toothisolation method used. However, slightly more sealants survived ...

  5. S. U. N. Y. Profiles of the Two-Year Colleges.

    Science.gov (United States)

    State Univ. of New York, Albany. Office of Access Services.

    Profiles of each of the six agricultural and technical colleges, 29 community colleges, and three other colleges offering two-year programs within the State University of New York (SUNY) system are presented. Tuition and other costs as well as availability of financial assistance are outlined. A description of the Educational Opportunity Program…

  6. Development of early communication skills in the first two years of life

    NARCIS (Netherlands)

    Beuker, K.T.; Lambregts-Rommelse, N.N.J.; Donders, R.; Buitelaar, J.K.

    2013-01-01

    The first two years of life is a crucially important period for the development of communication skills. In this study joint attention and language development were monthly assessed between 8 and 24 months of age in a sample of 23 typically developing children to establish the developmental

  7. Analyzing Four-Year Public University and Two-Year College Graduation Rates

    Science.gov (United States)

    Ober, David R.; Beekman, John A.; Pierce, Rebecca L.

    2018-01-01

    This paper examines the graduation rates between 2000 and 2015 of United States colleges and universities at the national, state, and institutional levels. This research focuses on two-year and four-year programs. Rates are investigated longitudinally along with variables that distinguish between public/private institutions, percentages of…

  8. The Wired Island: The First Two Years of Public Access To Cable Television In Manhattan.

    Science.gov (United States)

    Othmer, David

    A review is presented of the first two years of free public access programing on New York City's cable television (CATV) systems. The report provides some background information on franchising, public access to CATV in New York City, and Federal Communications Commission regulations. It also deals with the public access programing developed; it…

  9. Two-year outcome of team-based intensive case management for patients with schizophrenia.

    Science.gov (United States)

    Aberg-Wistedt, A; Cressell, T; Lidberg, Y; Liljenberg, B; Osby, U

    1995-12-01

    Two-year outcomes of patients with schizophrenic disorders who were assigned to an intensive, team-based case management program and patients who received standard psychiatric services were assessed. The case management model featured increased staff contact time with patients, rehabilitation plans based on patients' expressed needs, and patients' attendance at team meetings where their rehabilitation plan was discussed. Forty patients were randomly assigned to either the case management group or the control group that received standard services. Patients' use of emergency and inpatient services, their quality of life, the size of their social networks, and their relatives' burden of care were assessed at assignment to the study groups and at two-year follow-up. Patients in the case management group had significantly fewer emergency visits compared with the two years before the study, and their relatives reported significantly reduced burden of care associated with relationships with psychiatric services over the two-year period. The size of patients' social networks increased for the case management group and decreased for the control group. A team-based intensive case management model is an effective intervention in the rehabilitation of patients with chronic schizophrenia.

  10. Solitary Secondary Malignant Melanoma of Clavicle Two Years after Enuclation for Ocular Melanoma

    Directory of Open Access Journals (Sweden)

    Halil Tozum

    2013-01-01

    Full Text Available Solitary metastasis of uveal melanoma to bone is extremely rare and usually associated with other organ involvement. We present a rare case of an ocular melanoma patient presenting with solitary metastasis to the clavicle two years after enucleation, without any other organ involvement. In this report, we tried to present our treatment strategy for the solitary metastasis of bone.

  11. The Pros and Cons of Two-Year Versus Four-Year Degrees.

    Science.gov (United States)

    Urbaniak, Anthony

    1985-01-01

    Reports results of a research survey conducted to determine what differences (job titles, income, relevance of courses, satisfaction, suitability) exist between two-year (Associate of Science) graduates and four-year (Bachelor of Science) graduates in business. Statistical tables are included. (CT)

  12. Faculty Motivation Toward Professional Improvement: A Study of Two-Year College Faculty.

    Science.gov (United States)

    Corwin, Luene Holmes

    Faculty from 16 food service and hotel technology programs in New York two-year colleges were surveyed to determine the components of faculty decisions concerning participation in professional improvement activities aimed at updating knowledge, to explore the function and relationship of the components of a composite expectancy model which…

  13. Anaemia, Malaria and malnutrition in the first two years of life in ...

    African Journals Online (AJOL)

    Anaemia, Malaria and malnutrition in the first two years of life in Nigeria. B M Afolabi, A G Mafe. Abstract. No Abstract. Journal of Malaria in Africa and the Tropics Vol. 1 (3) 2005: pp. 15-27. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT.

  14. Results of a Two-Year Longitudinal Study of Beverage-Specific Alcohol Use among Adolescents

    Science.gov (United States)

    Moore, Michele Johnson; Werch, Chudley

    2007-01-01

    This study explored beverage-specific alcohol consumption patterns among a sample of high school students over a two-year period. Four hundred fifty-five students completed the validated questionnaire at all three time points (2002, 2003, 2004). Variables of interest included five use measures (past year use, 30-day frequency, quantity, heavy use,…

  15. Alveolar Ridge Preservation Using a Novel Synthetic Grafting Material: A Case with Two-Year Follow-Up

    Directory of Open Access Journals (Sweden)

    Peter Fairbairn

    2018-01-01

    Full Text Available This case report highlights the use of a novel in situ hardening synthetic (alloplastic, resorbable, bone grafting material composed of beta tricalcium phosphate and calcium sulfate, for alveolar ridge preservation. A 35-year-old female patient was referred by her general dentist for extraction of the mandibular right first molar and rehabilitation of the site with a dental implant. The nonrestorable tooth was “atraumatically” extracted without raising a flap, and the socket was immediately grafted with the synthetic biomaterial and covered with a hemostatic fleece. No membrane was used, and the site was left uncovered without obtaining primary closure, in order to heal by secondary intention. After 12 weeks, the architecture of the ridge was preserved, and clinical observation revealed excellent soft tissue healing without loss of attached gingiva. At reentry for placement of the implant, a bone core biopsy was obtained, and primary implant stability was measured by final seating torque and resonance frequency analysis. Histological analysis revealed pronounced bone regeneration while high levels of primary implant stability were recorded. The implant was successfully loaded 12 weeks after placement. Clinical and radiological follow-up examination at two years revealed stable and successful results regarding biological, functional, and esthetic parameters.

  16. Training nuclear technicians in two-year, post-secondary educational programs

    International Nuclear Information System (INIS)

    Hull, D.M.; Roney, M.W.

    1975-01-01

    An available and economical supply to future manpower requirements for various types of nuclear technicians can be met by developing and/or restructuring two-year, post-secondary programs at local educational institutions. The Technical Education Research Centers program is under contract from the U.S. Office of Education to delineate the job requirements and develop curricula and instructional materials for two-year, post-secondary training of nuclear technicians. Six job categories have been identified along with corresponding tasks which the technician performs. These categories are: Reactor Operator, Nuclear Instrumentation Technician, Nuclear QA/QC Technician, Radiochemistry Technician, Radiation Protection Technician and Nuclear Medicine Technician. For the first five categories curricula have been established, courses have been described, and instructional materials are being written

  17. Two years of real progress in European HEP networking: A CERN perspective

    International Nuclear Information System (INIS)

    Carpenter, B.E.; Fluckiger, F.; Gerard, J.M.; Lord, D.; Segal, B.

    1987-01-01

    The last two years have been marked by real progress in networking in HEP. Home-made developments, studies and plans have given way to the use of real networks involving hundreds of HEP and other computers and based on externally produced software and hardware. Within the last year, the first generation of industrial software products following some of the international standards for networking have become available. Related developments are taking place in networking for on-line systems and indeed the LEP experiments are distinguished by their heavy and crucial reliance on both local and wide-area networks. This paper describes the progress made at CERN since the last two years and looks at perspectives for the future. (orig.)

  18. A juvenile case of radiation-induced meningioma two years after radiation for craniopharyngioma

    International Nuclear Information System (INIS)

    Kano, Tomoaki; Zama, Akira; Ono, Nobuo; Nakamura, Tadashi; Tamura, Masaru; Ohe, Tihiro; Nakazato, Yoichi

    1994-01-01

    The patient was a 7-years-old boy who received radiation therapy of 50 Gy after total gross removal of a craniopharyngioma. After two years a follow up CT scan showed a new enhanced lesion in the right temporal tip within the previous irradiation field. Total removal of the tumor was performed and its histological examination showed it to be an atypical meningioma. This atypical meningioma satisfied Cahan's criteria. So we diagnosed this atypical meningioma as radiation-induced meningioma. Immunohistochemically this meningioma stained for Vimentin. An electron microscopical examination showed neither desmosome nor interdigitation. The score of Ki-67 and BrdU-L. I was very small. Compared with previously reported juvenile radiation-induced meningioma, the latency was very short. The patient received growth hormone (GH) replacement therapy. We suspected relation between GH replacement therapy and short latency. He was discharged without any new neurological deficits and we haven't detected tumor recurrence for two years. (author)

  19. Severity of Giardia infection associated with post-infectious fatigue and abdominal symptoms two years after

    Directory of Open Access Journals (Sweden)

    Rortveit Guri

    2009-12-01

    Full Text Available Abstract Background A high rate of post-infectious fatigue and abdominal symptoms two years after a waterborne outbreak of giardiasis in Bergen, Norway in 2004 has previously been reported. The aim of this report was to identify risk factors associated with such manifestations. Methods All laboratory confirmed cases of giardiasis (n = 1262 during the outbreak in Bergen in 2004 received a postal questionnaire two years after. Degree of post-infectious abdominal symptoms and fatigue, as well as previous abdominal problems, was recorded. In the statistical analyses number of treatment courses, treatment refractory infection, delayed education and sick leave were used as indices of protracted and severe Giardia infection. Age, gender, previous abdominal problems and symptoms during infection were also analysed as possible risk factors. Simple and multiple ordinal logistic regression models were used for the analyses. Results The response rate was 81% (1017/1262, 64% were women and median age was 31 years (range 3-93, compared to 61% women and 30 years (range 2-93 among all 1262 cases. Factors in multiple regression analysis significantly associated with abdominal symptoms two years after infection were: More than one treatment course, treatment refractory infection, delayed education, bloating and female gender. Abdominal problems prior to Giardia infection were not associated with post-infectious abdominal symptoms. More than one treatment course, delayed education, sick leave more than 2 weeks, and malaise at the time of infection, were significantly associated with fatigue in the multiple regression analysis, as were increasing age and previous abdominal problems. Conclusion Protracted and severe giardiasis seemed to be a risk factor for post-infectious fatigue and abdominal symptoms two years after clearing the Giardia infection.

  20. Two-year results of femtosecond assisted LASIK versus PRK for different severity of astigmatism

    OpenAIRE

    Mohammad Miraftab; Hassan Hashemi; Soheila Asgari

    2018-01-01

    Purpose: To compare two-year results of femtosecond laser assisted LASIK (femto-LASIK) and photorefractive keratectomy (PRK) in terms of astigmatism correction in patients with less than 2.0 diopters (D) of spherical error and more than 2.0 D of cylinder error. Methods: In this retrospective study, data were extracted from 100 patient charts. The two study groups were matched by age, gender, and baseline uncorrected distance visual acuity (UDVA) and refractive astigmatism (RA). Preoperativ...

  1. Two years post-stroke, Luxembourgish informal caregivers’ life satisfaction and their couple and family repercussions

    OpenAIRE

    Lurbe-Puerto, Katia; Baumann, Michèle; Le Bihan, Etienne

    2010-01-01

    This study aims to improve our understanding of the changes in the couple and family lives of stroke survivors’ caregivers and to analyse the relationships between the Caregivers’ Life Satisfaction (CLS) and the social and emotional repercussions of the caregiving role, two years after this event. Life satisfaction, optimism about the future, happiness and other subjective well-being aspects have attracted the European policymakers, leading to the Eurofund to introduce a “life satisfaction” d...

  2. Intestinal perforation in a two-year-old child with eosinophilic gastroenteritis

    DEFF Research Database (Denmark)

    Agertoft, A; Husby, S; Høst, A

    1991-01-01

    A two-year-old boy underwent a laparatomy for an intestinal perforation due to eosinophilic gastroenteritis. He had marked peripheral blood eosinophilia and a small duodenal biopsy showed heavy eosinophilic infiltration in the mucosa. After 1 1/2 year on a restricted diet, a control duodenal biopsy...... showed only slight eosinophilia. Perforation of the small intestine is a rare but serious complication in eosinophilic gastroenteritis....

  3. [Two years clinical observation of a kind of castable ceramic--IPS Empress].

    Science.gov (United States)

    Liu, Y; Li, Y; Nie, Y

    1999-03-01

    We used this material in clinic since 1995. Discussion on the prosthetic effects of the above-mentioned material to spreat it clinically. Through half to two years clinical observations to evaluate the effect of IPS Empress crowns in anterior teeth and inlays in posteriors. and Prosthesis made of this kind of material IPS Empress is one kind of excellent all-ceramic prosthetic material. IPS Empress also could be used in post crowns and the clinical effect was satisfactory.

  4. eBooks for Libraries and Patrons: Two Years of Experience

    Directory of Open Access Journals (Sweden)

    Richard L. Rosy

    2002-07-01

    Full Text Available A little over two years ago, netLibrary defined its primary mission to encompass a singular focus on developing and offering library-centric solutions for organizing, hosting, and serving digital learning content in ways that integrated with the mission and methods of libraries. Today, netLibrary provides thousands of academic, public, government, corporate, special and school libraries with access to digital versions of monograph content they deem of particular value to their patrons.

  5. Varicella vaccination coverage of children under two years of age in Germany

    Directory of Open Access Journals (Sweden)

    Reuss Annicka M

    2010-08-01

    Full Text Available Abstract Background Since July 2004, routine varicella vaccination is recommended by the German Standing Vaccination Committee in Germany. Health Insurance Funds started to cover vaccination costs at different time points between 2004 and 2006 in the Federal States. Nationwide representative data on vaccination coverage against varicella of children under two years of age are not available. We aimed to determine varicella vaccination coverage in statutory health insured children under two years of age in twelve German Federal States using data from associations of statutory health insurance physicians (ASHIPs, in order to investigate the acceptance of the recommended routine varicella vaccination programme. Methods We analysed data on varicella vaccination from 13 of 17 ASHIPs of the years 2004 to 2007. The study population consisted of all statutory health insured children under two years of age born in 2004 (cohort 2004 or 2005 (cohort 2005 in one of the studied regions. Vaccination coverage was determined by the number of children vaccinated under 2 years of age within the study population. Results Varicella vaccination coverage of children under two years of age with either one dose of the monovalent varicella vaccine or two doses of the measles, mumps, rubella, and varicella vaccine increased from 34% (cohort 2004 to 51% (cohort 2005 in the studied regions (p Conclusions Our study shows increasing varicella vaccination coverage of young children, indicating a growing acceptance of the routine varicella vaccination programme by the parents and physicians. We recommend further monitoring of vaccination coverage using data from ASHIPs to investigate acceptance of the routine vaccination programmes over time.

  6. Cooled radiofrequency denervation for treatment of sacroiliac joint pain: two-year results from 20 cases

    Science.gov (United States)

    Ho, Kok-Yuen; Hadi, Mohamed Abdul; Pasutharnchat, Koravee; Tan, Kian-Hian

    2013-01-01

    Background Sacroiliac joint pain is a common cause of chronic low back pain. Different techniques for radiofrequency denervation of the sacroiliac joint have been used to treat this condition. However, results have been inconsistent because the variable sensory supply to the sacroiliac joint is difficult to disrupt completely using conventional radiofrequency. Cooled radiofrequency is a novel technique that uses internally cooled radiofrequency probes to enlarge lesion size, thereby increasing the chance of completely denervating the sacroiliac joint. The objective of this study was to evaluate the efficacy of cooled radiofrequency denervation using the SInergy™ cooled radiofrequency system for sacroiliac joint pain. Methods The charts of 20 patients with chronic sacroiliac joint pain who had undergone denervation using the SInergy™ cooled radiofrequency system were reviewed at two years following the procedure. Outcome measures included the Numeric Rating Scale for pain intensity, Patient Global Impression of Change, and Global Perceived Effect for patient satisfaction. Results Fifteen of 20 patients showed a significant reduction in pain (a decrease of at least three points on the Numeric Rating Scale). Mean Numeric Rating Scale for pain decreased from 7.4 ± 1.4 to 3.1 ± 2.5, mean Patient Global Impression of Change was “improved” (1.4 ± 1.5), and Global Perceived Effect was reported to be positive in 16 patients at two years following the procedure. Conclusion Cooled radiofrequency denervation showed long-term efficacy for up to two years in the treatment of sacroiliac joint pain. PMID:23869175

  7. Two-year clinical evaluation of IPS Empress II ceramic onlays/inlays.

    Science.gov (United States)

    Tagtekin, D A; Ozyöney, G; Yanikoglu, F

    2009-01-01

    The stronger the ceramic material, the longer the restoration stays in the mouth. The current study evaluated the two-year clinical performance of a strong ceramic system, IPS Empress II, with increased strength on onlay/inlay restorations of molars. Teeth from 35 patients, including three premolars and 32 molars, were prepared for 28 onlay and seven inlay restorations with IPS Empress II ceramics. The restorations were cemented with a highly viscous, dual-curing luting composite cement (Bifix) and evaluated by two examiners using USPHS criteria at baseline (one week following insertion), six months, one year and two years. The baseline scores and recalls were assessed by Wilcoxon signed rank test. Statistically significant marginal discoloration at the Bravo level was found at the 12- and 24-month recalls (p=0.046). One debonding was statistically insignificant. No changes were observed with respect to anamnesis, such as any symptom from the TMJ or masticatory muscles. No restorations were replaced due to hypersensitivity or were missing at the two-year evaluation. Any wear on the restoration, antagonist tooth or any changes of proximal contacts were not observed. IPS Empress II Ceramics were found to be appropriate as onlay/inlay restorations for clinical use under the conditions of the current study.

  8. Supporting Geoscience Students at Two-Year Colleges: Career Preparation and Academic Success

    Science.gov (United States)

    McDaris, J. R.; Kirk, K. B.; Layou, K.; Macdonald, H.; Baer, E. M.; Blodgett, R. H.; Hodder, J.

    2013-12-01

    Two-year colleges play an important role in developing a competent and creative geoscience workforce, teaching science to pre-service K-12 teachers, producing earth-science literate citizens, and providing a foundation for broadening participation in the geosciences. The Supporting and Advancing Geoscience Education in Two-Year Colleges (SAGE 2YC) project has developed web resources for geoscience faculty on the preparation and support of students in two-year colleges (2YCs). Online resources developed from two topical workshops and several national, regional, and local workshops around the country focus on two main categories: Career Preparation and Workforce Development, and Supporting Student Success in Geoscience at Two-year Colleges. The Career Preparation and Workforce Development resources were developed to help faculty make the case that careers in the geosciences provide a range of possibilities for students and to support preparation for the geoscience workforce and for transfer to four-year programs as geoscience majors. Many two-year college students are unaware of geoscience career opportunities and these materials help illuminate possible futures for them. Resources include an overview of what geoscientists do; profiles of possible careers along with the preparation necessary to qualify for them; geoscience employer perspectives about jobs and the knowledge, skills, abilities and attitudes they are looking for in their employees; employment trends in sectors of the economy that employ geoscience professionals; examples of geotechnician workforce programs (e.g. Advanced Technological Education Centers, environmental technology programs, marine technician programs); and career resources available from professional societies. The website also provides information to support student recruitment into the geosciences and facilitate student transfer to geoscience programs at four- year colleges and universities, including sections on advising support before

  9. The Two-Year College as a First Choice, Second Chance Institution for Baccalaureate-Degree Holders

    Science.gov (United States)

    Townsend, Barbara K.

    2009-01-01

    This study focused on degree-seeking baccalaureate-degree holders at one two-year technical institute in the Midsouth to determine why they chose to study at the two-year college and how they compared their two-year college experience with their baccalaureate educational experience. Findings indicated the technical college was their first choice…

  10. Preoperative MRI findings predict two-year postoperative clinical outcome in lumbar spinal stenosis.

    Directory of Open Access Journals (Sweden)

    Pekka Kuittinen

    Full Text Available To study the predictive value of preoperative magnetic resonance imaging (MRI findings for the two-year postoperative clinical outcome in lumbar spinal stenosis (LSS.84 patients (mean age 63±11 years, male 43% with symptoms severe enough to indicate LSS surgery were included in this prospective observational single-center study. Preoperative MRI of the lumbar spine was performed with a 1.5-T unit. The imaging protocol conformed to the requirements of the American College of Radiology for the performance of MRI of the adult spine. Visual and quantitative assessment of MRI was performed by one experienced neuroradiologist. At the two-year postoperative follow-up, functional ability was assessed with the Oswestry Disability Index (ODI 0-100% and treadmill test (0-1000 m, pain symptoms with the overall Visual Analogue Scale (VAS 0-100 mm, and specific low back pain (LBP and specific leg pain (LP separately with a numeric rating scale from 0-10 (NRS-11. Satisfaction with the surgical outcome was also assessed.Preoperative severe central stenosis predicted postoperatively lower LP, LBP, and VAS when compared in patients with moderate central stenosis (p<0.05. Moreover, severe stenosis predicted higher postoperative satisfaction (p = 0.029. Preoperative scoliosis predicted an impaired outcome in the ODI (p = 0.031 and lowered the walking distance in the treadmill test (p = 0.001. The preoperative finding of only one stenotic level in visual assessment predicted less postoperative LBP when compared with patients having 2 or more stenotic levels (p = 0.026. No significant differences were detected between quantitative measurements and the patient outcome.Routine preoperative lumbar spine MRI can predict the patient outcome in a two-year follow up in patients with LSS surgery. Severe central stenosis and one-level central stenosis are predictors of good outcome. Preoperative finding of scoliosis may indicate worse functional ability.

  11. Off Label Use of Botulinum Toxin in Children under Two Years of Age: A Systematic Review

    Directory of Open Access Journals (Sweden)

    Claudia Druschel

    2013-01-01

    Full Text Available The treatment of children with cerebral palsy with Botulinum Toxin is considered safe and effective, but is only approved for children older than two years of age. The effect of BoNT-A injection on juvenile skeletal muscle especially on neuromuscular junction density, distribution and morphology is poorly delineated and concerns of irreversible damage to the motor endplates especially in young children exist. In contrast, earlier treatment could be appropriate to improve the attainment of motor milestones and general motor development. This review systematically analyzes the evidence regarding this hypothesis. A database search, including PubMed and Medline databases, was performed and all randomized controlled trials (RCTs comparing the efficacy of Botulinum Toxin in children younger than two years were identified. Two authors independently extracted the data and the methods of all identified trials were assessed. Three RCTs met the inclusion criteria. The results of the analysis revealed an improvement in spasticity of the upper and lower extremities as well as in the range of motion in the joints of the lower limbs. However, evidence of an improvement of general motor development could not be found, as the assessment of this area was not completely specified for this patient group. Based on available evidence it can not be concluded that Botulinum Toxin treatment in children younger than two years improves the achievement of motor milestones. However, there is evidence for the reduction of spasticity, avoiding contractures and delaying surgery. Due to some limitations, the results of this review should be cautiously interpreted. More studies, long-term follow up independent high-quality RCTs with effectiveness analyses are needed.

  12. Rotational Grazing System for Beef Cows on Dwarf Elephantgrass Pasture for Two Years after Establishment

    Directory of Open Access Journals (Sweden)

    M Mukhtar

    2011-01-01

    Full Text Available An intensive rotational grazing system for dwarf and late heading (DL elephant grass (Pennisetum purpureum Schumach pasture was examined in a summer period for two years following establishment. Four 0.05 of DL elephant grass pastures (20×25 m were established on May 2003. They were rotationally grazed for 1 week, followed by a 3-week rest period by three breeding or raising beef cattle for three and six cycles during the first and second years of establishment respectively. Before grazing, the plant height, leaf area index and the ratio of leaf blade to stem were at the highest, while tiller number increased and herbage mass tended to increase, except for the first grazing cycle both two years and for one paddock in the second year. Herbage consumption, the rate of herbage consumption and dry matter intake tended to decrease in three paddocks from the first to the third cycle in the first year, but increase as grazing occurred in the second year. Dry matter intake averaged 10.2-14.5 and 15.4–23.2 g DM/kg/live weight (LW/day over the four paddocks in the first and second year, respectively, and average daily gains were 0.09 and 0.35 kg/head/day in the first and second year respectively. The carrying capacities were estimated at 1,016 and 208 cow-days (CD/ha (annual total 1,224 CD/ha in the first year and 1,355 and 207 CD/ha (annual total 1,562 CD/ha in the second year. Thus, DL elephant grass pasture can expand the grazing period for beef cows for the following two-year establishment. (Animal Production 13(1:10-17 (2011 Key Words: dwarf elephant grass, herbage mass, plant characters, rotational grazing

  13. Creating Authentic Geoscience Research Experiences for Underrepresented Students in Two-Year Undergraduate Programs

    Science.gov (United States)

    Liou-Mark, J.; Blake, R.

    2014-12-01

    With community college and two-year program students playing pivotal roles in advancing the nation's STEM agenda now and throughout the remainder of this young millennia, it is incumbent on educators to devise innovative and sustainable STEM initiatives to attract, retain, graduate, and elevate these students to four-year programs and beyond. Involving these students in comprehensive, holistic research experiences is one approach that has paid tremendous dividends. The New York City College of Technology (City Tech) was recently awarded a National Science Foundation Research Experiences for Undergraduates (REU) supplemental grant to integrate a community college/two-year program component into its existing REU program. The program created an inviting and supportive community of scholars for these students, nurtured them through strong, dynamic mentoring, provided them with the support structures needed for successful scholarship, and challenged them to attain the same research prominence as their Bachelor degree program companions. Along with their colleagues, the community college/two-year program students were given an opportunity to conduct intensive satellite and ground-based remote sensing research at the National Oceanic and Atmospheric Administration Cooperative Remote Sensing Science and Technology Center (NOAA-CREST) at City College and its CREST Institute Center for Remote Sensing and Earth System Science (ReSESS) at City Tech. This presentation highlights the challenges, the rewards, and the lessons learned from this necessary and timely experiment. Preliminary results indicate that this paradigm for geoscience inclusion and high expectation has been remarkably successful. (The program is supported by NSF REU grant #1062934.)

  14. Undergraduate Research in Geoscience with Students from Two-year Colleges: SAGE 2YC Resources

    Science.gov (United States)

    McDaris, J. R.; Hodder, J.; Macdonald, H.; Baer, E. M.; Blodgett, R. H.

    2014-12-01

    Undergraduate research experiences are important for the development of expertise in geoscience disciplines. These experiences have been shown to help students learn content and skills, promote students' cognitive and affective development, and develop students' sense of self. Early exposure to research experiences has shown to be effective in the recruitment of students, improved retention and persistence in degree programs, motivation for students to learn and increase self-efficacy, improved attitudes and values about science, and overall increased student success. Just as departments at four-year institutions (4YCs) are increasingly integrating research into their introductory courses, two-year college (2YC) geoscience faculty have a great opportunity to ground their students in authentic research. The Undergraduate Research with Two-year College Students website developed by SAGE 2YC: Supporting and Advancing Geoscience Education at Two-year Colleges provides ideas and advice for 2YC and 4YC faculty who want to get more 2YC students involved in research. The continuum of possibilities for faculty to explore includes things that can be done at 2YCs (eg. doing research as part of a regular course, developing a course specifically around research on a particular topic, or independent study), done in collaboration with other local institutions (eg. using their facilities, conducting joint class research, or using research to support transfer programs), and by involving students in the kind of organized Undergraduate Research programs run by a number of institutions and organizations. The website includes profiles illustrating how 2YC geoscience faculty have tackled these various models of research and addressed potential challenges such as lack of time, space, and funding as part of supporting the wide diversity of students that attend 2YCs, most of whom have less experience than that of rising seniors who are the traditional REU participant. The website also

  15. A Model of the Earth's Magnetic Field From Two Year of Swarm Satellite Constellation Data

    DEFF Research Database (Denmark)

    Olsen, Nils; Finlay, Chris; Tøffner-Clausen, Lars

    More than two year of data from ESA's Swarm constellation mission are used to derive a model of the Earth’s magnetic field and its time variation (secular variation). The model describes contributions from the core and lithosphere as well as large-scale contributions from the magnetosphere (and its...... Earth-induced counterpart). We use data from geomagnetic quiet times and co-estimate the Euler angles describing the rotation between the vector magnetometer instrument frame and the North-East-Center (NEC) frame. In addition to the magnetic field observations provided by each of the three Swarm...

  16. Prostate cancer outcomes in France: treatments, adverse effects and two-year mortality

    Science.gov (United States)

    2014-01-01

    Background This very large population-based study investigated outcomes after a diagnosis of prostate cancer (PCa) in terms of mortality rates, treatments and adverse effects. Methods Among the 11 million men aged 40 years and over covered by the general national health insurance scheme, those with newly managed PCa in 2009 were followed for two years based on data from the national health insurance information system (SNIIRAM). Patients were identified using hospitalisation diagnoses and specific refunds related to PCa and PCa treatments. Adverse effects of PCa treatments were identified by using hospital diagnoses, specific procedures and drug refunds. Results The age-standardised two-year all-cause mortality rate among the 43,460 men included in the study was 8.4%, twice that of all men aged 40 years and over. Among the 36,734 two-year survivors, 38% had undergone prostatectomy, 36% had been treated by hormone therapy, 29% by radiotherapy, 3% by brachytherapy and 20% were not treated. The frequency of treatment-related adverse effects varied according to age and type of treatment. Among men between 50 and 69 years of age treated by prostatectomy alone, 61% were treated for erectile dysfunction and 24% were treated for urinary disorders. The frequency of treatment for these disorders decreased during the second year compared to the first year (erectile dysfunction: 41% vs 53%, urinary disorders: 9% vs 20%). The frequencies of these treatments among men treated by external beam radiotherapy alone were 7% and 14%, respectively. Among men between 50 and 69 years with treated PCa, 46% received treatments for erectile dysfunction and 22% for urinary disorders. For controls without PCa but treated surgically for benign prostatic hyperplasia, these frequencies were 1.5% and 6.0%, respectively. Conclusions We report high survival rates two years after a diagnosis of PCa, but a high frequency of PCa treatment-related adverse effects. These frequencies remain

  17. Two years of wind-lidar measurements at an Italian Mediterranean Coastal Site

    DEFF Research Database (Denmark)

    Gullí, D.; Avolio, E.; Calidonna, C. R.

    2017-01-01

    Reliable measurements of vertical profiles of wind speed and direction are needed for testing models and methodologies of use for wind energy assessment. In particular, modelling complex terrain such as coastal areas is challenging due to the coastal discontinuity that is not accurately resolved...... in mesoscale numerical model. Here, we present a unique database from a coastal site in South Italy (middle of the Mediterranean area) where vertical profiles of wind speed and direction have been collected during a two-year period from a wind-lidar ZEPHIR-300® at a coastal-suburban area. We show an overview...

  18. The European Journal of Case Reports in Internal Medicine – The First Two Years

    Directory of Open Access Journals (Sweden)

    John Kellett

    2016-06-01

    Full Text Available The European Journal of Case Reports in Internal Medicine (EJCRIM is just over two years old. To date 400 reports have been submitted and just under half have been accepted for publication. In order to keep costs down our initial policy was to charge a small fee for all submissions, and a further small publication fee for papers that were accepted. However, we have now abolished the submission charge and replaced it with a single, slightly increased, publication charge for all accepted papers.

  19. Two years of the operation of a domestic MBR wastewater treatment plant

    Science.gov (United States)

    Pikorová, Tina

    2012-06-01

    The paper evaluates the results of data obtained from two years of observing an actual domestic wastewater treatment plant (WWTP) with an immersed membrane module. The domestic MBR (membrane bioreactor) WWTP was linked to a dwelling with four residents. Two different commercial flat sheet membrane modules were investigated. The membrane modules, as well as the whole WWTP, were tested with different fluxes as well as the response of the membrane and activated sludge to different conditions, such as actual peak wastewater flows, extremes temperatures (a winter below 5 °C), and high pH values.

  20. Two Years of Simultaneous K(sub a)-Band Measurements: Goldstone, CA; White Sands, NM; and Guam, USA

    Science.gov (United States)

    Acosta, Roberto J.; Zemba, M.; Morse, J.; Nessel, J.

    2012-01-01

    In order to statistically characterize the effect of the Earth's atmosphere on Ka-Band links, site test interferometers (STIs) have been deployed at three of NASA s operational sites to directly measure each site's tropospheric phase stability and rain attenuation. These STIs are composed of two antennas on a short baseline (less than 1km) that observe the same unmodulated beacon signal broadcast from a geostationary satellite (e.g., Anik F2). The STIs are used to measure the differential phase between the two received signals as well as the individual signal attenuation at each terminal. There are currently three NASA sites utilizing STIs; the Goldstone Deep Space Communications Complex near Barstow, California; the White Sands Complex in Las Cruces, New Mexico; and the Guam Remote Ground Terminal on the island of Guam. The first two sites are both located in desert regions that have highly similar climates in terms of their seasonal temperatures, average humidity, and annual rain fall (the primary factors in determining phase stability). In contrast, Guam is in a tropical region with drastically higher annual rainfall and humidity. Five station years of data have been collected in Goldstone, three in White Sands, and two in Guam, yielding two years of simultaneous data collection across all three sites. During this period of simultaneous data collection, the root-mean-square (RMS) of the time delay fluctuations stayed under 2.40 picoseconds for 90% of the time in Goldstone, under 2.07 picoseconds for 90% of the time in White Sands, and under 10.13 picoseconds for 90% of the time in Guam. For the 99th percentile, the statistics were 6.32 ps, 6.03 ps, and 24.85 ps, respectively. These values, as well as various other site quality characteristics, will be used to determine the suitability of these sites for NASA s future communication services at Ka-Band.

  1. The posture of adolescent male handball players: A two-year study.

    Science.gov (United States)

    Grabara, Małgorzata

    2018-02-06

    Young athletes at the stage of growth acceleration tend to exhibit increased susceptibility to postural abnormalities, especially in the trunk region. The aim of this study was to assess and compare the posture in male adolescent handball players over two years of regular training sessions. The study group comprised 21 handball players. At the start of the study 15 participants were aged 14 and 6 participants were aged 15 (mean 14.25 ± 0.58). The measurements were repeated three times. Posture was assessed with a photogrammetric method based on the moiré phenomenon. The analysis of posture relative to symmetry in the frontal and transverse planes did not reveal any significant differences between posture indicators obtained during the successive measurements. Sagittal plane posture indicators revealed significant changes in torso forward inclination angle and the shape of anteroposterior spinal curvatures. The latter consisted of significant deepening of the upper thoracic curve (angle α) and flattening of the lumbosacral curve (angle γ). A two-year period of handball training did not result in posture asymmetries in young male handball players. The observed changes in the shape of anteroposterior spinal curvatures might be related both to sports training and somatic parameters.

  2. Lack of effect of zinc sulfate on wheezing after bronchiolitis in infants less than two years

    Directory of Open Access Journals (Sweden)

    R Abasi

    2014-10-01

    Full Text Available Backgrounds & aim: Wheezing after bronchiolitis is known as a risk factor for asthma. No cure or effective vaccine has been identified for such disease. The purpose of this study was to determine the effects of zinc sulfate on persistent wheezing after bronchiolitis in infants less than two years. Methods: The present randomized clinical trial study was conducted on 90 infants under two years of age suffering from the first attack with a clinical diagnosis of bronchiolitis wheezing hospitalized in Imam Sajjad Hospital, Yasuj. All infants were equally placed in test groups and control group. In addition to bronchiolitis usual treatment, test group received 20 mg of elemental zinc for seven days. Patient information including risk factors associated with wheezing and persistent wheezing were compared 48 hours and two weeks after treatment. Data were analyzed using chi-square and t tests. Results: In all 90 infants diagnosed with bronchiolitis, wheezing was observed. After 48 hours and two weeks wheezing was continued in 67 patients (74.4% and 54 patients (60% respectively Conclusion: The results showed Zinc sulfate had no effect on the improvement of wheezing after bronchiolitis.

  3. A juvenile case of radiation-induced meningioma two years after radiation for craniopharyngioma

    Energy Technology Data Exchange (ETDEWEB)

    Kano, Tomoaki; Zama, Akira; Ono, Nobuo; Nakamura, Tadashi; Tamura, Masaru; Ohe, Tihiro; Nakazato, Yoichi (Gunma Univ., Maebashi (Japan). School of Medicine)

    1994-04-01

    The patient was a 7-years-old boy who received radiation therapy of 50 Gy after total gross removal of a craniopharyngioma. After two years a follow up CT scan showed a new enhanced lesion in the right temporal tip within the previous irradiation field. Total removal of the tumor was performed and its histological examination showed it to be an atypical meningioma. This atypical meningioma satisfied Cahan's criteria. So we diagnosed this atypical meningioma as radiation-induced meningioma. Immunohistochemically this meningioma stained for Vimentin. An electron microscopical examination showed neither desmosome nor interdigitation. The score of Ki-67 and BrdU-L. I was very small. Compared with previously reported juvenile radiation-induced meningioma, the latency was very short. The patient received growth hormone (GH) replacement therapy. We suspected relation between GH replacement therapy and short latency. He was discharged without any new neurological deficits and we haven't detected tumor recurrence for two years. (author).

  4. [Dietary factors and their relation to appetite in children under two years with mild malnutrition].

    Science.gov (United States)

    Quijada, Mariana Martínez; Gutiérrez, María Luisa Alvarez

    2012-06-01

    Malnutrition is conditioned by a series of factors, among them the dietary factors, which include appetite, eating behaviors and habits. In order to assess these factors, the following objective was pursued: describe the dietary factors and their relation to appetite in children under two years of age with mild malnutrition. A correlational study was conducted. The sample consisted of all children under two years of age (n = 168) diagnosed with primary (mild) malnutrition, who attended consultation at the Centro de Atención Nutricional Infantil Antímano, CANIA, during the period 2000-2008. The results showed intake of energy and macronutrients was lower than the individual requirement; iron intake < 85% of the requirement, in accordance with the Recommended Dietary Allowances (RDA) in over 50% of the sample; weekly consumption of vegetables (57%) and miscellaneous (66%) was inadequate; inadequate intake of formula and whole milk in more than 60%; 9% were exclusively breastfed during the first six months; 64% lacked a regular eating place; in child-caregiver interaction during mealtimes, more than half of the children showed rebellious behavior and caregivers were permissive. Protein adequacy, vegetable and whole milk consumption frequency, preparation type, identification of refusals and preferences, place and duration of meals, and child-caregiver interaction at mealtimes were significantly associated with appetite; if we consider this last one as a guide and we try to modify inadequate eating behaviors and habits, we will generate an impact over the child appetite that could improve the food consumption and prevent malnutrition.

  5. Estimated risk of radiation-induced cancer from paediatric chest CT: two-year cohort study

    Energy Technology Data Exchange (ETDEWEB)

    Niemann, Tilo [Cantonal Hospital Baden, Department of Radiology, Baden (Switzerland); University Lille Nord de France, Department of Thoracic Imaging, Hospital Calmette, Lille (France); Colas, Lucie; Santangelo, Teresa; Faivre, Jean Baptiste; Remy, Jacques; Remy-Jardin, Martine [University Lille Nord de France, Department of Thoracic Imaging, Hospital Calmette, Lille (France); Roser, Hans W.; Bremerich, Jens [University of Basel Hospital, Clinic of Radiology and Nuclear Medicine, Medical Physics, Basel (Switzerland)

    2015-03-01

    The increasing absolute number of paediatric CT scans raises concern about the safety and efficacy and the effects of consecutive diagnostic ionising radiation. To demonstrate a method to evaluate the lifetime attributable risk of cancer incidence/mortality due to a single low-dose helical chest CT in a two-year patient cohort. A two-year cohort of 522 paediatric helical chest CT scans acquired using a dedicated low-dose protocol were analysed retrospectively. Patient-specific estimations of radiation doses were modelled using three different mathematical phantoms. Per-organ attributable cancer risk was then estimated using epidemiological models. Additional comparison was provided for naturally occurring risks. Total lifetime attributable risk of cancer incidence remains low for all age and sex categories, being highest in female neonates (0.34%). Summation of all cancer sites analysed raised the relative lifetime attributable risk of organ cancer incidence up to 3.6% in female neonates and 2.1% in male neonates. Using dedicated scan protocols, total lifetime attributable risk of cancer incidence and mortality for chest CT is estimated low for paediatric chest CT, being highest for female neonates. (orig.)

  6. Trajectories of depressive symptoms over two years postpartum among overweight or obese women

    Science.gov (United States)

    Lee, Chien-Ti; Stroo, Marissa; Fuemmeler, Bernard; Malhotra, Rahul; Østbye, Truls

    2014-01-01

    Background Although depressive symptoms are common postpartum, few studies have followed women beyond 12 months postpartum to investigate changes in the number and severity of these symptoms over time, especially in overweight and obese women. Using two complementary analytical methods, this study aims to identify trajectories of depressive symptoms over two years postpartum among overweight or obese mothers, and assess the demographic, socio-economic , and health covariates for these trajectories. Methods Using longitudinal data from two behavioral intervention studies (KAN-DO and AMP; N = 844), we used latent growth modeling to identify the overall trajectory of depressive symptoms and how it was related to key covariates. Next, we used latent class growth analysis to assess the heterogeneity in the depressive symptom trajectories over time, and thereby, identify subgroups of women with distinct trajectories. Findings The overall trajectory of depressive symptoms over two years postpartum was relatively stable in our sample. However, the presence of three distinct latent class trajectories [stable-low (82.5%), decreasing symptoms (7.3%) and increasing symptoms (10.2%)], identified based on trajectory shape and mean depressive symptom score, supported heterogeneity in depressive symptom trajectories over time. Lower maternal education was related to a higher symptom score, and poorer subjective health status at baseline predicted inclusion in the increasing symptoms trajectory. Conclusions In some overweight or obese mothers postpartum depressive symptoms do not resolve quickly. Practitioners should be aware of this phenomenon and continue to screen for depression for longer periods of time postpartum. PMID:25213748

  7. Patient’s Cross-border Mobility Directive: Application, Performance and Perceptions Two Years after Transposition

    Directory of Open Access Journals (Sweden)

    Riedel Rafał

    2016-10-01

    Full Text Available This paper seeks to analyse the directive on the application of patients’ rights in cross-border healthcare. Two years after the transposition, it is time for first evaluations of its application, performance and perception. The analysis consists of three major elements: reconstruction of the legal scope and subject matter of the new legislation, conclusions of the evaluative reports monitoring its implementation and performance as well as the public opinion polls revealing the EU citizens’ perception of its details. These three components combined together deliver a picture of the state of play about the pan-European cross-border patients’ mobility. The bottomline conclusions negatively verify the supposition present in some earlier literature on patients’ cross-border mobility that the directive has a transformative potential leading towards the creation of truly competitive pan-European medical market. After two years of its operation, there is still no increased patients’ mobility across EU internal borders observed. As regards the speculations for the future, there are only some weak symptoms identified and they may result in intensified cross-border mobility for healthcare.

  8. Health and re-employment in a two year follow up of long term unemployed.

    Science.gov (United States)

    Claussen, B; Bjørndal, A; Hjort, P F

    1993-02-01

    The aim was to examine re-employment and changes in health during a two year follow up of a representative sample of long term unemployed. This was a cross sectional study and a two year follow up. Health was measured by psychometric testing, Hopkins symptom checklist, General health questionnaire, and medical examination. Health related selection to continuous unemployment and recovery by re-employment was estimated by logistic regression with covariances deduced from the labour market theories of human capital and segmented labour market. Four municipalities in Greenland, southern Norway. Participants were a random sample of 17 to 63 year old people registered as unemployed for more than 12 weeks. In the cross sectional study, the prevalence of depression, anxiety, and somatic illness was from four to 10 times higher than in a control group of employed people. In the follow up study, there was considerable health related selection to re-employment. A psychiatric diagnosis was associated with a 70% reduction in chances of obtaining a job. Normal performance on psychometric testing showed a two to three times increased chance of re-employment. Recovery of health following re-employment was less than expected from previous studies. Health related selection to long term unemployment seems to explain a substantial part of the excess mental morbidity among unemployed people. An increased proportion of the long term unemployed will be vocationally handicapped as years pass, putting a heavy burden on social services.

  9. Energy Extension Service Pilot Program: evaluation report after two years. Volume I. Evaluation summary

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-04-01

    The EES pilot program was initiated in August 1977, when 10 states were selected on a competitive basis for participation. The pilot states (Alabama, Connecticut, Michigan, New Mexico, Pennsylvania, Tennessee, Texas, Washington, Wisconsin, and Wyoming) devoted the first 6 months to start-up activities. This document is a follow-up report to the three volume Evaluation Summary of the first year of the pilot EES program published in September 1979. The purpose of this report is to provide an overview of the impacts and costs of the two years of the pilot program, and to check the consistency of findings over the two year period. The analysis addresses the following: (1) were the impact findings of Year I and Year II consistent, or did Year I and Year II attitudes and behavior vary. If variation existed, could it be attributed to program changes as the EES progressed from a start-up phase (Year I) to more normal service delivery (Year II); and (2) did costs of service delivery change (again reflecting start-up and normal service delivery costs). Did cost changes affect conclusions about the relative cost effectiveness of delivering services to different target audiences.

  10. [The over the counter drugs reform in Israel--two years later].

    Science.gov (United States)

    Vaknin, Sharona; Abadi-Korek, Ifat; Marom, Eli; Shemer, Joshua; Luxenburg, Osnat

    2011-01-01

    In the last two decades there has been a world wide increase in the number of drugs that are being switched from the prescription-only category to non-prescription categories. In Israel, until recently, non-prescription medicines were only permitted to be sold by a pharmacist in pharmacies. In May 2005, following amendments to the law, several non-prescription medicines which were previously sold under a pharmacist's supervision, were reclassified as general-sales-list (GSL) medicines and permitted to be displayed and sold directly off the shelves in pharmacies and in other places such as grocery stores and petrol stations. To study the change in the patterns of consumption of non-prescription drugs in Israel two years after the reform began. A representative sample of the population of Israel was chosen and interviews were conducted at two time points: before the reform commenced and two years after the beginning of the reform. Statistical processing was performed in order to examine the changes in patterns of consumption of non-prescription drugs in Israel between these two time points. In both surveys it was found that: approximately 70% of the Israeli public buys non-prescription medicines; 70% of the people interviewed said that they had been aware of the reform, but of these, about 75% continued buying nonprescription drugs from the pharmacist while 21% bought medicines off the shelves at the pharmacy and 4% purchased medications at grocery stores. The most common reasons for buying medicines off the shelves without a pharmacist were earlier knowLedge about the medication, convenience and availabiLity when the pharmacies were closed. An insignificant difference was observed for the purchase of non-prescription drugs from the different types of pharmacies: the health maintenance organizations (HMO) pharmacies continue to be the leading pharmacies from which the public purchased their non-prescription medicines, white there was a slight increase in the

  11. Health-related quality of life two years after injury due to terrorism.

    Science.gov (United States)

    Tuchner, Maya; Meiner, Zeev; Parush, Shula; Hartman-Maeir, Adina

    2010-01-01

    During the past few decades, terrorist acts have been an unfortunate reality worldwide. There is a striking paucity of research investigating the multitude of long-term outcomes after severe physical injury due to terrorist attacks, a unique subgroup of trauma patients. The purpose of this study was to provide a profile of the long-term health-related quality of life (HR-QOL) after injury due to terrorist attacks and to explore the relationships between Post Traumatic Stress Disorder (PTSD), occupational status and injury severity with HR-QOL. We included 35 survivors of terrorist attacks living in the community, two years on average after the injury, mean age at follow-up = 32.1 (±13.8), mean Injury Severity Score (ISS) = 27 (±14.2). The subjects were recruited from consecutive admissions to a rehabilitation department in a tertiary care center between September 2000 - June 2004. Most of the subjects suffered multiple trauma. The main outcome measures were the Short-Form Health Survey (SF-36), Post Traumatic Diagnostic Scale and return to work rates. The mean scores on 6/8 of the SF-36 subscales were significantly lower among the survivors compared to normative population norms. Post Traumatic Stress Disorder (PTSD) was found in 39% of the sample and 43% did not resume their main occupation two years after the injury. Multivariate analysis of variance of PTSD and occupational status (returned vs. did not return to work) on quality of life scores revealed significant main effects for both PTSD (p=. 000) and occupational status (p=. 005) with no interaction effect (p=. 476). No significant correlations were found between injury severity and the SF-36 scores. This study demonstrated the long-term impact of injury due to terrorism. Results showed independent effects of PTSD and occupational status on health related quality of life, two years after injury. These findings suggest that this group may benefit from intervention focusing on their emotional and

  12. [Reconstruction of the heel in a two-year-old boy after lawn mower injury].

    Science.gov (United States)

    Kraus, R; Albrecht, J; Schnettler, R; von Pichler, M

    2012-04-01

    Lawn mower injuries in children usually involve the lower extremities and can lead to serious amputation injuries. Treatment should look not only at the acute reconstruction, but also on maintaining the ability to grow. We report the case of a two-year-old boy with amputation of the heel. The boy was run over by a lawn mower. He suffered a complete loss of heel soft tissue, 30 % of the os calcis and the Achilles tendon. The one-stage reconstruction was performed by transplantation of an iliac crest graft, fascia lata to reconstruct the Achilles tendon and a microvascular latissimus dorsi flap. After one year, the functional and cosmetic result is excellent, the bone graft is healed completely and shows growth trends. The successful treatment of such a severe amputation injury requires the interdisciplinary cooperation between paediatric traumatologists, plastic surgeons, physical therapists and orthopaedic shoemaker. The result justifies the great effort. © Georg Thieme Verlag KG Stuttgart · New York.

  13. Self-Rated Health as a Predictor of Death after Two Years

    DEFF Research Database (Denmark)

    Vejen, Marie; Bjorner, Jakob B.; Bestle, Morten H.

    2017-01-01

    Introduction. The objective of this study is, among half-year intensive care survivors, to determine whether self-assessment of health can predict two-year mortality. Methods. The study is a prospective cohort study based on the Procalcitonin and Survival Study trial. Half-year survivors from...... this 1200-patient multicenter intensive care trial were sent the SF-36 questionnaire. We used both a simple one-item question and multiple questions summarized as a Physical Component Summary (PCS) and a Mental Component Summary (MCS) score. The responders were followed for vital status 730 days after...... inclusion. Answers were dichotomized into a low-risk and a high-risk group and hazard ratios (HR) with 95% confidence interval (CI) were calculated by Cox proportional hazard analyses. Conclusion. We found that self-rated health measured by a single question was a strong independent predictor of two...

  14. Endoscopic sinus surgery: results at two year follow-up on 200 patients

    International Nuclear Information System (INIS)

    Khademi, B.; Gandomi, B.; Chohedri, A.H.; Eghadami, H.

    2007-01-01

    The technique of functional endoscopic sinus surgery (FESS) has been widely accepted and applied to inflammatory diseases of the paranasal sinuses with internationally reported results of this technique having been very good. Our objective was to find out outcome after FESS at our centre. Two hundred patients who had undergone FESS during a two year period with an average follow-up period of eleven months were evaluated subjectively regarding the outcome of their endoscopic sinus surgery. An overall subjective improvement of about 94% was documented, with improvement in specific symptoms such as headache, nasal congestion, change in sense of smell, nasal discharge and recurrent infections ranging from 52% to 97%. Our center reports a subjective improvement of symptoms following FESS compatible with results attained internationally. (author)

  15. Two-year predictors of runaway and homeless episodes following shelter services among substance abusing adolescents.

    Science.gov (United States)

    Slesnick, Natasha; Guo, Xiamei; Brakenhoff, Brittany; Feng, Xin

    2013-10-01

    Given high levels of health and psychological costs associated with the family disruption of homelessness, identifying predictors of runaway and homeless episodes is an important goal. The current study followed 179 substance abusing, shelter-recruited adolescents who participated in a randomized clinical trial. Predictors of runaway and homeless episodes were examined over a two year period. Results from the hierarchical linear modeling analysis showed that family cohesion and substance use, but not family conflict or depressive symptoms, delinquency, or school enrollment predicted future runaway and homeless episodes. Findings suggest that increasing family support, care and connection and reducing substance use are important targets of intervention efforts in preventing future runaway and homeless episodes amongst a high risk sample of adolescents. Copyright © 2013 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

  16. Monthly radiation protection training of workers: An evaluation of two years operational practice

    International Nuclear Information System (INIS)

    Berus, D.; Covens, P.

    2011-01-01

    Radiation protection training and education is important in stimulating safety culture of occupationally exposed workers. Taking into account the mandatory requirements in relation to education and training a digital training tool was introduced for communication of personal dose results and regular information on radiation protection. This tool enables that personal dose reports are monthly sent to the individual mailbox of workers together with short comprehensive slideshows on radiation protection topics. After two years of operational practice a survey was organised to evaluate the training tool. The results show that the majority (92%) of the occupationally exposed workers are aware of the communication of personal dose results through e-mail. Furthermore, 81% of these workers are also aware of their monthly and cumulated dose level. The monthly information on radiation protection topics is however less consulted. Around 40% of the workers that noticed the link are indifferent to the monthly information. The interest in radiation protection issues increases however with the education level.

  17. Two years since SSAMS: Status of {sup 14}C AMS at CAIS

    Energy Technology Data Exchange (ETDEWEB)

    Ravi Prasad, G.V.; Cherkinsky, Alexander; Culp, Randy A.; Dvoracek, Doug K.

    2015-10-15

    The NEC 250 kV single stage AMS accelerator (SSAMS) was installed two years ago at the Center for Applied Isotope Studies (CAIS), University of Georgia. The accelerator is primarily being used for radiocarbon measurements to test the authenticity of natural and bio-based samples while all other samples such as geological, atmospheric, marine and archaeological. are run on the 500 kV, NEC 1.5SDH-1 model tandem accelerator, which has been operating since 2001. The data obtained over a six months period for OXI, OXII, ANU sucrose and FIRI-D are discussed. The mean value of ANU sucrose observed to be slightly lower than the consensus value. The processed blanks on SSAMS produce lower apparent age compared to the tandem accelerator as expected.

  18. Surface air concentration and deposition of lead-210 in French Guiana: two years of continuous monitoring

    International Nuclear Information System (INIS)

    Melieres, Marie-Antoinette; Pourchet, Michel; Richard, Sandrine

    2003-01-01

    To make up for the lack of data on 210 Pb aerosol deposition in tropical regions and to use this radionuclide as an aerosol tracer,a monitoring station was run for two years at Petit-Saut, French Guiana. Lead-210 concentration in air at ground level was monitored continuously together with atmospheric total deposition. The air concentration has a mean value of 0.23±0.02 mBq m -3 during both wet and dry seasons, and it is only weakly affected by the precipitation mechanism. This result was unexpected in a wet tropical region, with a high precipitation rate. In contrast, deposition clearly correlates with precipitation for low/moderate rainfall ( -2 y -1 . This provides a procedure fo estimating this mean flux at other sites in French Guiana

  19. What We Need: The 2012 NASA EPO Forum Survey on Two-Year College STEM Teaching

    Science.gov (United States)

    Low, R.; CoBabe-Ammann, E.; Schultz, G.

    2014-07-01

    A survey of community college STEM faculty, administered by the NASA SMD Higher Education Working Group (HEWG), was administered in fall 2012 in an effort to document the demographic make-up and views of community college faculty who teach NASA science-related STEM courses in astronomy, physics, Earth science, and engineering. Nearly half of respondents reported that less than 10% of students in their classroom are “STEMward bound” and indicated the need for STEM resources that can relate science course content and be relevant to the daily life of their students. A number of respondents also noted a new or renewed emphasis on outreach activities within the community served by their institution as part of their job description. The survey suggests specific directions and ways that the NASA SMD EPO forum can support two-year college stakeholders.

  20. Livedo reticularis due to pellagra in a two year old child

    Directory of Open Access Journals (Sweden)

    Biju Vasudevan

    2014-01-01

    Full Text Available A two-year-old girl child was admitted with complaints of diarrhoea of one week duration in the paediatric ward. She was referred to the skin OPD for gradually progressive skin rashes on both lower limbs noticed since two days. Dermatological examination revealed finding of livedo reticularis. Dietary history revealed maize forming a significant portion of the child′s diet since the age of nine months. The child was treated with a course of Niacin in the form of Nicotinamide 50 mg twice a day for 4 weeks and the parents were advised not to give her maize in the diet. The skin lesions and diarrhoea regressed in duration of two weeks. This is probably the first time that a case of pellagra causing livedo is being reported, that too in a child.

  1. Evaluation of water beef buffalo from birth to two years using different growth curves

    Directory of Open Access Journals (Sweden)

    W.R. Lamberson

    2010-02-01

    Full Text Available The buffalo is a domestic animal species of growing world-wide importance. Research to improve genetic improvement programs is important to maintain the productivity of buffalo. The objective this research was to evaluate the growth of Brazilian buffalo to two years of age with different growth curves. Growth curves consolidate the information contained in the weight-age data into three or four biologically meaningful parameters. The data included 31,452 weights at birth and 120, 205, 365, 550 and 730 days of buffalo (n = 5,178 raised on pasture without supplementation. Logistic, Gompertz, quadratic logarithmic, and linear hyperbolic curves (designated L, G, QL, and LH, respectively were fitted to the data by using proc NLIN of SAS (SAS Institute, Inc., Cary, NC, USA. The parameters estimates for L [WT= A * (((1 + exp (-k * AGE**-m] were A = 865.1 ± 5.42; k= 0.0028 ± 0.00002; M= 3.808 ± 0.007; R2 = 0.95. For G [WT= A * exp (-b * exp (-k * age] the parameters estimates were A= 967.6 ± 7.23; k = 0.00217 ± 0.000015; b = -2.8152 ± 0.00532. For QL [WT= A + b*age + k*(age*age + m*log (age] parameters estimates were A= 37.41 ± 0.48; k= 0.00019 ± 6.4E-6; b= 0.539 ± 0.006; m= 2.32 ± 0.23; R2=0.96. For LH [WT= A + b*AGE + k*(1/AGE] the parameters estimates were A= 23.15 ± 0.44; k=15.16 ± 0.66; b= 0.707 ± 0.001; R2= 0.96. Each of these curves fit these data equally well and could be used for characterizing growth to two years in beef buffalo.

  2. Functional performance of school children diagnosed with developmental delay up to two years of age

    Science.gov (United States)

    Dornelas, Lílian de Fátima; Magalhães, Lívia de Castro

    2016-01-01

    Abstract Objective: To compare the functional performance of students diagnosed with developmental delay (DD) up to two years of age with peers exhibiting typical development. Methods: Cross-sectional study with functional performance assessment of children diagnosed with DD up to two years of age compared to those with typical development at seven to eight years of age. Each group consisted of 45 children, selected by non-random sampling, evaluated for motor skills, quality of home environment, school participation and performance. ANOVA and the Binomial test for two proportions were used to assess differences between groups. Results: The group with DD had lower motor skills when compared to the typical group. While 66.7% of children in the typical group showed adequate school participation, receiving aid in cognitive and behavioral tasks similar to that offered to other children at the same level, only 22.2% of children with DD showed the same performance. Although 53.3% of the children with DD achieved an academic performance expected for the school level, there were limitations in some activities. Only two indicators of family environment, diversity and activities with parents at home, showed statistically significant difference between the groups, with advantage being shown for the typical group. Conclusions: Children with DD have persistent difficulties at school age, with motor deficit, restrictions in school activity performance and low participation in the school context, as well as significantly lower functional performance when compared to children without DD. A systematic monitoring of this population is recommended to identify needs and minimize future problems. PMID:26553573

  3. Two-years therapy with bosentan of pulmonary arterial hypertension related to connective tissue diseases

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    M. Rizzo

    2011-09-01

    Full Text Available Objective: Pulmonary arterial hypertension (PAH is a rare but severe complication of connective tissue diseases (CTD, with a negative impact on patients survival. Bosentan, a receptor antagonist of endothelin, has been proved effective for the treatment of PAH. The aim of this study was to evaluate the effects and the safety of bosentan administered for 2 years in a group of patients with PAH related to CTD. Methods: Twelve patients with PAH related to systemic sclerosis (8 cases, SLE (2 cases, mixed connective tissue disease (1 case and polymyositis (1 case attending the Rheumatology Unit of Padova University were treated with bosentan for two years. Distance walked in 6 minutes, right ventricular systolic pressure and mean pulmonary artery pressure estimated by doppler echocardiography were evaluated at baseline and after 6, 12, 18 and 24 months of treatment. Safety was assessed by laboratory tests performed every two months. Results: During bosentan treatment, a significant decrease of right ventricular systolic pressure was observed after 6, 12, 18 and 24 months in comparison to baseline, whereas pulmonary artery mean pressure remained unchanged. Distance walked in 6 minutes slightly increased after 6 and 12 months, but significantly decreased after 18 and 24 months, mostly because complications of CTD which compromised the ability to walk arose in 4 patients. Adverse events related to bosentan were observed in 2 cases. Conclusions: Bosentan has been demonstrated effective in reducing pulmonary arterial pressure in a two-year period of treatment. Exercise capacity improved only in the first year of therapy and worsened thereafter, suggesting the opportunity of a combination therapy for a long-term treatment of PAH related to CTD.

  4. Functional performance of school children diagnosed with developmental delay up to two years of age

    Directory of Open Access Journals (Sweden)

    Lílian de Fátima Dornelas

    2016-03-01

    Full Text Available Abstract Objective: To compare the functional performance of students diagnosed with developmental delay (DD up to two years of age with peers exhibiting typical development. Methods: Cross-sectional study with functional performance assessment of children diagnosed with DD up to two years of age compared to those with typical development at seven to eight years of age. Each group consisted of 45 children, selected by non-random sampling, evaluated for motor skills, quality of home environment, school participation and performance. ANOVA and the Binomial test for two proportions were used to assess differences between groups. Results: The group with DD had lower motor skills when compared to the typical group. While 66.7% of children in the typical group showed adequate school participation, receiving aid in cognitive and behavioral tasks similar to that offered to other children at the same level, only 22.2% of children with DD showed the same performance. Although 53.3% of the children with DD achieved an academic performance expected for the school level, there were limitations in some activities. Only two indicators of family environment, diversity and activities with parents at home, showed statistically significant difference between the groups, with advantage being shown for the typical group. Conclusions: Children with DD have persistent difficulties at school age, with motor deficit, restrictions in school activity performance and low participation in the school context, as well as significantly lower functional performance when compared to children without DD. A systematic monitoring of this population is recommended to identify needs and minimize future problems.

  5. [Functional performance of school children diagnosed with developmental delay up to two years of age].

    Science.gov (United States)

    Dornelas, Lílian de Fátima; Magalhães, Lívia de Castro

    2016-01-01

    To compare the functional performance of students diagnosed with developmental delay (DD) up to two years of age with peers exhibiting typical development. Cross-sectional study with functional performance assessment of children diagnosed with DD up to two years of age compared to those with typical development at seven to eight years of age. Each group consisted of 45 children, selected by non-random sampling, evaluated for motor skills, quality of home environment, school participation and performance. ANOVA and the Binomial test for two proportions were used to assess differences between groups. The group with DD had lower motor skills when compared to the typical group. While 66.7% of children in the typical group showed adequate school participation, receiving aid in cognitive and behavioral tasks similar to that offered to other children at the same level, only 22.2% of children with DD showed the same performance. Although 53.3% of the children with DD achieved an academic performance expected for the school level, there were limitations in some activities. Only two indicators of family environment, diversity and activities with parents at home, showed statistically significant difference between the groups, with advantage being shown for the typical group. Children with DD have persistent difficulties at school age, with motor deficit, restrictions in school activity performance and low participation in the school context, as well as significantly lower functional performance when compared to children without DD. A systematic monitoring of this population is recommended to identify needs and minimize future problems. Copyright © 2015 Sociedade de Pediatria de São Paulo. Publicado por Elsevier Editora Ltda. All rights reserved.

  6. Studying Disabling Occupational Accidents in the Construction Industry During Two Years

    Directory of Open Access Journals (Sweden)

    Ahmad Soltanzadeh

    2014-06-01

    Full Text Available Background & Objectives : Idnetifying causes of occupational accidents is a key issue to prevent these accidents. The present study aimed to identify and analyze debilitating accidents in the construction industry during a two-year period ( 2010 - 2011 years . Methods: This was an analytical cross-sectional study. The study data included information about all debilitating accidents occurred within two years. Data collection was performed according to the accident report forms in construction sites. Data analysis was performed using SPSS software version 16. The level of significance was considered as P=0.05. Results: The mean age and job experience of injured people were 27.95±6.95 and 2.34±2.00 years, respectively. Most injuries to people were reported in hand (35.4%, legs (28.3% and back (20.4%. Most of accident types were respectively related to slipping and falling (26.1%, throwing objects (21.7%, falls (18.6%, abrasion (16.8% and clash (16.4%. Moreover, the main causes of accidents were related to lack of housekeeping (97.3%, lack of proper training (85.8%, lack of PPE (73.0%, unsafe acts (63.3%, unsafe conditions (32.3% and equipment (22.6%. Conclusion: Analyzing causes of disabling accidents in the construction industry showed that important factors in these accidents included lack of housekeeping, failure to provide proper training, lack of suitable PPE, unsafe acts, unsafe conditions and equipment for the construction jobs

  7. COEXISTENCE OF CARCINOMAS OF THYROID WITH MULTINODULAR GOITRES OF THYROID – A TWO-YEAR STUDY

    Directory of Open Access Journals (Sweden)

    Kiran Kumar Epari

    2016-08-01

    Full Text Available BACKGROUND Multinodular goitre or nodular hyperplasia or adenomatoid goitre is the most common thyroid disease, which occurs due to deficient iodine intake. Initial hyperthyroid states, followed by follicular atrophy and secondary changes like haemorrhage, calcification and cystic degeneration occurs in most of the cases. Longstanding cases of nodular goitre can be associated with carcinomas, usually follicular carcinomas, and rarely papillary carcinomas.[1] This study was done to know the incidence of coexisting malignancies, follicular and papillary carcinomas of thyroid, in longstanding nodular goitres of thyroid. METHODS All the cases of nodular goitres examined in the last two years were studied, including the thyroidectomy specimens and FNAC slides whichever was done. Extensive grossing of the thyroidectomy specimens was done to detect the possibility of malignancy in longstanding cases of nodular goitre of thyroid. Review of FNAC slides was done in cases where cytodiagnosis of coexisting malignancy was missed and detected in histopathological examination. RESULTS In the present study, conducted over a two-year period, out of 50 cases of thyroidectomy specimens of multinodular goitres studied, six cases were diagnosed to be having coexisting malignancy of thyroid, of which four were follicular carcinomas of thyroid and two were papillary carcinomas of thyroid. FNAC diagnosis of coexisting malignancy was initially missed in FNAC in two cases, i.e. one case each of follicular carcinoma and papillary carcinoma. These FNAC slides were reviewed and the foci of malignancies detected. CONCLUSION There is a possibility of malignancy of thyroid coexisting with longstanding multinodular goitre of thyroid, which should be kept in mind, while performing the needle biopsy and thorough examination of FNAC slides is needed to avoid missing the possible detection of the coexisting malignant lesion. Thyroidectomy specimens should be extensively grossed to

  8. Primary Ewing’s Sarcoma of the Spine in a Two-Year-Old Boy

    Directory of Open Access Journals (Sweden)

    Ali J. Electricwala

    2016-01-01

    Full Text Available Ewing’s Sarcoma (ES is a highly malignant bone tumour. It may involve any part of the skeleton but the most frequent parts are the ilium and diaphysis of femur and tibia (Alfeeli et al., 2005; Zhu et al., 2012. Primary ES of the spine is extremely rare (Yan et al., 2011. It accounts for only 3.5 to 14.9 percent of all primary bone sarcomas. The age of presentation ranges from 12 to 24 years (median 21 years (Ferguson, 1999; Sharafuddin et al., 1992; Klimo Jr. et al., 2009. We report an unusual case of primary ES of the spine in a two-year-old boy, who presented to us with paraparesis and features of cauda equina syndrome. MRI scan showed a tumour mass arising from the pedicle of L4 vertebra invading the spinal canal. Tc-99 bone scan showed increased tracer uptake in L4 vertebra and normal tracer uptake elsewhere in the skeleton. After reaching the diagnosis of a space occupying lesion invading the lumber spinal canal, we performed a decompressive laminectomy and a biopsy was sent which confirmed the diagnosis of ES. Immunohistochemistry showed tumour cells staining positive for CD-99 (specific stain for ES. Gene testing showed an EWS-FLI 1 chimera. Surgery was followed by good improvement in motor signs. The child was then referred to a specialized oncotherapy centre for further treatment, radiation, and chemotherapy. To the best of our knowledge, we are the first to report primary ES of the spine at the age of two years.

  9. Clinical manifestations of atopy in children up to two years of age

    Directory of Open Access Journals (Sweden)

    Ilić Nevenka

    2011-01-01

    Full Text Available Background/Aim. Atopic diseases such as atopic dermatitis, allergic rhinitis and asthma have had increased prevalence during the past decade and nowadays occur in every third child in developed countries. The aim of the study was to determine frequency and type of atopic diseases at the age of two, as well as the importance the total IgE antibodies concentrations have in diagnosis and prognosis of the disease. Methods. The study involved 175 children up to two years of age. Allergy-like symptoms were found after surveying their parents and pediatric medical records. Using the fluorescence immunossay (FIA method, total IgE antibodies concentrations and specific IgE antibodies (Phadiatop infant were determined on an Immunocap 100 Dyagnostic System. Results. One or more allergy-like symptoms accounted for 57.7% of findings in children under the age of two, whilst in 19.4% the existence of IgE-related allergic diseases was found. Atopic diseases usually have clinical manifestations of atopic dermatitis (11.4%, IgE-bound wheezing/asthma (10.8% and food allergies (7.4%, and to much lesser extent those of allergic rhinitis (3.4% and urticaria (1.7%. The significantly higher total IgE antibodies concentrations were found in children with allergy-like symptoms (p < 0.0005 (cut-off 15.15 kU/L, sensitivity 76.5% specificity 71.6%. Conclusion. Almost 20% of two-year-old children have any of clinically manifested allergic diseases, with atopic dermatitis and IgE wheeze/asthma being predominant. The higher total IgE antibodies concentration is a good marker for sensitization in children with allergy-like symptoms.

  10. Two-year water degradation of self-etching adhesives bonded to bur ground enamel.

    Science.gov (United States)

    Abdalla, Ali I; Feilzer, Albert J

    2009-01-01

    To evaluate the effect of water storage on the microshear bond strength to ground enamel of three "all-in-one" self-etch adhesives: Futurabond DC, Clearfil S Tri Bond and Hybrid bond; a self-etching primer; Clearfil SE Bond and an etch-and-rinse adhesive system, Admira Bond. Sixty human molars were used. The root of each tooth was removed and the crown was sectioned into two halves. The convex enamel surfaces were reduced by polishing on silicon paper to prepare a flat surface that was roughened with a parallel-sided diamond bur with abundant water for five seconds. The bonding systems were applied on this surface. Prior to adhesive curing, a hollow cylinder (2.0 mm in height/0.75 mm in internal diameter) was placed on the treated surfaces and cured. A resin composite was then inserted into the tube and cured. For each adhesive, two procedures were carried out: A--the specimens were kept in water for 24 hours, then the tube was removed and the microshear bond strength was determined in a universal testing machine at a crosshead speed of 0.5 mm/minute; B--the specimens were stored in water for two-years before microshear testing. The fractured surface of the bonded specimens after each test procedure was examined by SEM. For the 24-hour control, there was no significant difference in bond strength between the tested adhesives. After two years of water storage, the bond strength of Admira Bond, Clearfil SE Bond and Futurabond DC decreased, but the reduction was not significantly different from that of 24 hours. For Clearfil S Tri Bond and Hybrid Bond, the bond strengths were significantly reduced compared to their 24-hour results.

  11. Radiological and migration results of the DURALOC(R)-cup after two years

    International Nuclear Information System (INIS)

    Juen, F.

    2000-10-01

    In 1997 a study was conduced concerning 69 consecutive patients, all of whom consisted of DURALOC(R) series 100 acetabular components. The clinical, radiological and migrational aspect of each component was investigated 2 and 4 years postoperatively. In addition to this, a further 92 cups were analyzed in an identical manner, again 2 years after implantation. This therefore equated to a total of 161 investigated cups after a follow up interval of 2 years. In 144 of these cases the cup was combined with a cementless hydroxyapatite coated Spotorno shaft, with the remaining 17 involving a cemented Link-shaft (Lubinus SP II). A 28 mm Biolox(R) ceramic head was constant in all cases. Clinical data for each cup was collected via completion of a standard examination form, while acetabular migration, both vertical and horizontal, was measured on serial radiographs by the computer assisted EBRA method. From analyses of collected data, it was clearly shown that the clinical results remained very good over the 2- and 4-year-periods however, from radiological evidence it was indicated that for the period 3-4 years postoperatively, an increasing amount of radiolucencies around the cups were apparent. There was clearly no correlation between clinical and migration results. From the data taken from 106 migration curves, the mean total migration over the initial two-year-period was calculated to be 0.88 mm. From analysis of a further 56 migration curves, the mean total migration within 4 years of implantation was assessed to be 1.23 mm, however a decreasing speed of migration over the final 2-year-period was indicated. Our results demonstrate that statements relating to migration results of particular cups are more accurate after four years. However, statements about mean migration values are possible after two years. A migration speed of 1 mm total migration within the first 2 years after operation was predictive for radiological loosening of the cup after four years (p=0

  12. Diversion and injection of buprenorphine-naloxone film two years post-introduction in Australia.

    Science.gov (United States)

    Larance, Briony; Mattick, Richard; Ali, Robert; Lintzeris, Nicholas; Jenkinson, Rebecca; White, Nancy; Kihas, Ivana; Cassidy, Rosemary; Degenhardt, Louisa

    2016-01-01

    We report 2 years of post-marketing surveillance of the diversion and injection of buprenorphine-naloxone (BNX) film following its introduction in 2011. Interviews were conducted with people who inject drugs regularly (PWID) (2004-2013), opioid substitution therapy clients (2013, n = 492) and key experts (n = 44). Key outcomes were unsanctioned removal of supervised doses, diversion, injection and street price. Prevalence of past 6-month injection among PWID was adjusted for background availability of opioid substitution therapy medications using sales data. Among out-of-treatment PWID, the levels of regular (weekly+) BNX film injection were comparable to methadone and BNX tablets, and lower than mono-buprenorphine, adjusting for background availability. Fewer BNX film clients [3%; 95% (CI) 1-5] regularly injected their medication than mono-buprenorphine clients (25%; 95% CI 11-39), but at levels equivalent to those among methadone (3%; 95% CI 1-6) and BNX tablet clients (2%; 95% CI 0-6). Key experts perceived BNX film needed less supervised dosing time as it dissolved rapidly and was harder to remove from the mouth than sublingual tablets; however, removal of supervised doses was higher among BNX film clients (15%; 95% CI: 10-20) than methadone clients (3%; 95% CI 1-6), and not significantly different from BNX tablet (11%; 95% CI 2-21) and mono-buprenorphine clients (31%; 95% CI 16-46). Two years post-introduction, levels of BNX film diversion and injection remained comparable with those for methadone and BNX tablets, and lower than mono-buprenorphine. We found no evidence that BNX film has lower non-adherence and diversion than the tablet formulation. [Larance B, Mattick R, Ali R, Lintzeris N, Jenkinson R, White N, Kihas I, Cassidy R, Degenhardt L. Diversion and injection of buprenorphine-naloxone film two years post-introduction in Australia. Drug Alcohol Rev 2015]. © 2015 Australasian Professional Society on Alcohol and other Drugs.

  13. Professional Development Opportunities for Two-Year College Geoscience Faculty: Issues, Opportunities, and Successes

    Science.gov (United States)

    Baer, E. M.; Macdonald, H.; McDaris, J. R.; Granshaw, F. D.; Wenner, J. M.; Hodder, J.; van der Hoeven Kraft, K.; Filson, R. H.; Guertin, L. A.; Wiese, K.

    2011-12-01

    Two-year colleges (2YCs) play a critical role in geoscience education in the United States. Nearly half of the undergraduate students who take introductory geoscience do so at a 2YC. With awide reach and diverse student populations, 2YCs may be key to producing a well-trained, diverse and sufficiently large geoscience workforce. However, faculty at 2YCs often face many barriers to professional development including lack of financial resources, heavy and inflexible teaching loads, lack of awareness of opportunities, and few professional development resources/events targeted at their needs. As an example, at the 2009 GSA meeting in Portland, fewer than 80 of the 6500 attendees were from community colleges, although this was more than twice the 2YC faculty attendance the previous year. Other issues include the isolation described by many 2YC geoscience faculty who may be the only full time geoscientist on a campus and challenges faced by adjunct faculty who may have even fewer opportunities for professional development and networking with other geoscience faculty. Over the past three years we have convened several workshops and events for 2YC geoscience faculty including technical sessions and a workshop on funding opportunities for 2YC faculty at GSA annual meetings, a field trip and networking event at the fall AGU meeting, a planning workshop that examined the role of 2YCs in geoscience education and in broadening participation in the geosciences, two workshops supporting use of the 'Math You Need, When You Need It' educational materials that included a majority of 2YC faculty, and marine science summer institutes offered by COSEE-Pacific Partnerships for 2YC faculty. Our experience indicates that 2YC faculty desire professional development opportunities when the experience is tailored to the needs and character of their students, programs, and institutions. The content of the professional development opportunity must be useful to 2YC faculty -workshops and

  14. Two-year outcomes of open shoulder anterior capsular reconstruction for instability from severe capsular deficiency.

    Science.gov (United States)

    Dewing, Christopher B; Horan, Marilee P; Millett, Peter J

    2012-01-01

    To document outcomes after anterior capsulolabral reconstruction for recurrent shoulder instability in 15 patients (20 shoulders) who have had multiple failed stabilizations or collagen disorders. Twenty shoulders with recurrent instability underwent revision stabilization with allograft reconstruction of anterior capsulolabral structures, which re-creates the labrum and capsular ligaments. The patients comprised 3 men and 12 women (mean age, 26 years [range, 18 to 38 years]) in whom multiple prior repairs failed and who had disability from continued pain and instability. Patients could choose to undergo either arthrodesis or salvage allograft reconstruction or to live with permanent disability. Of the patients, 5 had Ehlers-Danlos syndrome whereas 10 had hyperlaxity syndromes without genetic confirmation. Failure was defined as further instability surgery. Pain, shoulder function, instability (dislocations/subluxation), and American Shoulder and Elbow Surgeons scores were documented. At follow-up, 9 of 20 shoulders (45%) remained stable. Recurrent instability was reported in 5 shoulders (25%), but the patients chose not to undergo further surgery. In the 14 shoulders without further stabilization (nonfailures), the mean American Shoulder and Elbow Surgeons score increased 43 points at a mean of 3.8 years (range, 2 to 6 years) postoperatively (P failed by progressing to instability surgery at a mean of 8.6 months (range, 2.8 to 24 months). In the 6 shoulders that failed, the mean number of prior surgeries was 8 (range, 3 to 15) compared with a mean of 4 prior surgeries (range, 1 to 16) for the 9 nonfailures. Treating patients in whom multiple stabilizations have failed remains challenging. In our series 9 shoulders (45%) remained completely stable at 3.8 years. Recurrent instability (3 reinjuries) requiring further stabilization occurred in 6 (30%). Subsequent treatment for non-instability reasons was performed in 3 (15%). Instability was reported but revision

  15. Two years of operating experience with the Seattle clinical neutron therapy facility

    International Nuclear Information System (INIS)

    Risler, R.; Brossard, S.; Eenmaa, J.; Kalet, I.; Wootton, P.

    1987-01-01

    After five years of planning, equipment acquisition, facility construction and beam testing the Seattle Clinical Neutron Therapy facility became operational in October 1984. In the past two years nearly 300 people have been treated in clinical trials. During this time 82 % of the planned treatment sessions were performed on schedule, 3 % had to be rescheduled for patient related reasons and 15 % because of equipment problems. The facility is at present running on a 5 days/week schedule: Three ten-hour treatment days, one maintenance day and one research day (radiobiology, therapy related physics). Short runs for short lived isotopes are done between patient treatments. The isocentric gantry, capable of 360 rotation is equipped with a variable collimator with 40 independent leaves. This collimation system allows the use of complex field shapes without the necessity of handling radioactive components like collimator inserts or blocks. It has turned out to be a very essential part for the efficient operation of the facility. Major causes for equipment downtime were associated with the control system, the beryllium target system, RF and magnet systems and the treatment gantry. (author)

  16. Risk Factors for Mortality in Hemodialysis Patients: Two-Year Follow-Up Study

    Directory of Open Access Journals (Sweden)

    Maria do Sameiro-Faria

    2013-01-01

    Full Text Available Background. End-stage renal disease (ESRD patients under hemodialysis (HD have high mortality rate. Inflammation, dyslipidemia, disturbances in erythropoiesis, iron metabolism, endothelial function, and nutritional status have been reported in these patients. Our aim was to identify any significant association of death with these disturbances, by performing a two-year follow-up study. Methods and Results. A large set of data was obtained from 189 HD patients (55.0% male; 66.4 ± 13.9 years old, including hematological data, lipid profile, iron metabolism, nutritional, inflammatory, and endothelial (dysfunction markers, and dialysis adequacy. Results. 35 patients (18.5% died along the follow-up period. Our data showed that the type of vascular access, C-reactive protein (CRP, and triglycerides (TG are significant predictors of death. The risk of death was higher in patients using central venous catheter (CVC (Hazard ratio [HR] =3.03, 95% CI = 1.49–6.13, with higher CRP levels (fourth quartile, compared with those with lower levels (first quartile (HR = 17.3, 95% CI = 2.40–124.9. Patients with higher TG levels (fourth quartile presented a lower risk of death, compared with those with the lower TG levels (first quartile (HR = 0.18, 95% CI = 0.05–0.58. Conclusions. The use of CVC, high CRP, and low TG values seem to be independent risk factors for mortality in HD patients.

  17. Engaging College Students at Two-year Campuses in Aerospace Research

    Science.gov (United States)

    Dirienzo, William

    2018-01-01

    College students at two-year campuses have unique challenges to their learning and are often "nontraditional" students, including first-generation and/or returning adult students. They have little or no exposure to research, related to science and aerospace or otherwise, and so they do not think of these fields as possible careers or understand how the disciplines operate. Exposing these students to real research projects, especially ones that include rocket payloads, have a dramatic effect on the interests and academic success of students. Projects such as these can be quite large and expensive, perhaps prohibitively so for small institutions. We engaged a group of these students through the RockOn and RockSat programs lead by the Colorado Space Grant Consortium, which are programs for postsecondary students to access space with relatively easy access and low cost. The student team designed, built, and flew a scientific payload on a suborbital sounding rocket launched at NASA's Wallops Flight Facility in Virginia. The experiment sent E. coli DNA samples into space to assess the damage and measured the radiation exposure with and without radiation shielding, and assessed the samples for DNA damage upon their return. We report on the process and the effects on the students as part of their experience.

  18. Microbially influenced corrosion of zinc and aluminium - Two-year subjection to influence of Aspergillus niger

    Energy Technology Data Exchange (ETDEWEB)

    Juzeliunas, Eimutis [Institute of Chemistry, A.Gostauto 9, 01108 Vilnius (Lithuania)], E-mail: ejuzel@ktl.mii.lt; Ramanauskas, Rimantas; Lugauskas, Albinas; Leinartas, Konstantinas; Samuleviciene, Meilute; Sudavicius, Aloyzas; Juskenas, Remigijus [Institute of Chemistry, A.Gostauto 9, 01108 Vilnius (Lithuania)

    2007-11-15

    Aspergillus niger. Tiegh., a filamentous ascomycete fungus, was isolated from the metal samples exposed to marine, rural and urban sites in Lithuania. Al and Zn samples were subjected to two-year influence of A. niger under laboratory conditions in humid atmosphere. Electrochemical impedance spectroscopy (EIS) ascertained microbially influenced corrosion acceleration (MICA) of Zn and inhibition (MICI) of Al. EIS data indicated a two-layer structure of corrosion products on Zn. The microorganisms reduced the thickness of the inner layer, whose passivating capacity was much higher when compared to that of the outer layer. An increase in aluminium oxide layer resistance but decrease in the layer thickness implied that MICI affected primarily the sites of localized corrosion of Al (pores, micro-cracks, etc.). X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) studies indicated that bioproducts (i.e. organic acids) did not form crystalline phases with corrosion products of zinc. The study suggested a hypothesis that microorganisms could be used as corrosion protectors instead of toxic chemicals, application of which tends to be increasingly restricted.

  19. Microbially influenced corrosion of zinc and aluminium - Two-year subjection to influence of Aspergillus niger

    International Nuclear Information System (INIS)

    Juzeliunas, Eimutis; Ramanauskas, Rimantas; Lugauskas, Albinas; Leinartas, Konstantinas; Samuleviciene, Meilute; Sudavicius, Aloyzas; Juskenas, Remigijus

    2007-01-01

    Aspergillus niger. Tiegh., a filamentous ascomycete fungus, was isolated from the metal samples exposed to marine, rural and urban sites in Lithuania. Al and Zn samples were subjected to two-year influence of A. niger under laboratory conditions in humid atmosphere. Electrochemical impedance spectroscopy (EIS) ascertained microbially influenced corrosion acceleration (MICA) of Zn and inhibition (MICI) of Al. EIS data indicated a two-layer structure of corrosion products on Zn. The microorganisms reduced the thickness of the inner layer, whose passivating capacity was much higher when compared to that of the outer layer. An increase in aluminium oxide layer resistance but decrease in the layer thickness implied that MICI affected primarily the sites of localized corrosion of Al (pores, micro-cracks, etc.). X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) studies indicated that bioproducts (i.e. organic acids) did not form crystalline phases with corrosion products of zinc. The study suggested a hypothesis that microorganisms could be used as corrosion protectors instead of toxic chemicals, application of which tends to be increasingly restricted

  20. The accident of the Fukushima-Daiichi nuclear plant. Status two years after the event

    International Nuclear Information System (INIS)

    2013-03-01

    In a first part, this report briefly recalls the circumstances and occurrence of the accident, gives an overview of actions undertaken by the IRSN (calculations of installation damages, modelling of contaminated air movements, simulations of radionuclide dispersion in the sea environment, information of French nationals in Japan, press and public information), and an overview of strength tests of nuclear installations (additional safety assessments and European stress tests). The second part gives an overview of the situation in Japan two years after the accident: evolution of governance in terms of nuclear risk management, condition of the Fukushima plant in January 2013, health and environmental impact and post-accidental management, actions undertaken by the IRSN (assessment of doses potentially received by populations, strengthening of cooperation between Japan and France in the field of severe accidents, participation to the Fukushima Dialogue). The third part presents the contribution of the IRSN to the strengthening of nuclear safety and radiation protection at the international level, at the European level, and in France

  1. A two-year follow-up on a program theory of return to work intervention.

    Science.gov (United States)

    Jensen, Anne Grete Claudi

    2013-01-01

    Validation of a salutogenic theory for return to work (RTW) and an associated program process theory. A longitudinal non-randomized one-year trial study design was used with a two-year follow-up and with comparison to a reference group. Changes in attitudes and active behaviour in the intervention group and at the workplace were supported by cognitive and behavioural approaches. The intervention group included 118 unskilled Danish public employees and privately employed house-cleaners on sick leave due to musculoskeletal and/or common mental illnesses. Significant improvements of work ability index and perceived health (SF36 subgroups) were reported. A significantly higher RTW and a shorter sick leave than in the reference group also emerged. Positive predictors of RTW were keeping the pre-sick-leave job and improving work ability index and physical impairment/role physical. Decline in self-efficacy was a negative predictor. Support for the theory and associated program process theory was found. The intervention seemed to influence RTW and the employees' attitudes, behaviour and health by affecting comprehensibility, meaningfulness and manageability. Sustainable RTW emerged from a synergism of support from the work place and improved personal resources, especially such as concern mental health. The approach is consistent with integrating health promotion in RTW.

  2. Two years experience with tunneled dialysis catheters in patients requiring haemodialysis

    International Nuclear Information System (INIS)

    Raheem, A.; Rana, A. I.; Ramzan, M.; Shah, R. A.; Mehmood, S. N.; Naseem, S.

    2014-01-01

    Objective: To look for survival rate and major reasons behind the failure of tunnelled dialysis catheters in patients on haemodialysis. Methods: The retrospective study was conducted at the Department of Interventional Radiology, Shifa International Hospital, Islamabad, and comprised records of 100 consecutive subjects from a list of patients in whom tunnelled cuffed catheters were placed from February 2009 to January 2011 and were followed up for two years. Data was collected on a proforma from the hospital database and medical records of patients. SPSS 19 was used for statistical analysis. Results: Of the total 122 catheters placed in 100 patients, 49(40.16%) were lost to follow-up. Of the remaining 73(59.83%) catheters, 38(52%) had achieved their desired function, while 35(48%) failed to achieve the target duration. Among the reasons of catheter failure, infection was the commonest at 13(37.14%) with infection rate of 0.24 per 1000 catheter days. According to Kaplan Meier analysis, catheter survival rates at 60, 90 and 180 days were 89%, 77% and 64% respectively. Mean effective duration of catheter was 129+-117 days. Conclusion: Tunnelled dialysis catheters can be safely used as vascular access till the maturation of fistula and may be an alternative to Arterio-Venous Fistula or graft for long-term vascular access if indicated. (author)

  3. Essential Thrombocythemia in a Two-year-old Child, Responsive to Hydroxyurea but Not Aspirin

    Directory of Open Access Journals (Sweden)

    Tariq N. Aladily

    2017-06-01

    Full Text Available Essential thrombocythemia (ET is a myeloproliferative neoplasm that occurs mostly in patients above the age of 50 years. Its incidence in children is very rare, with around 100 cases reported in the literature. High-risk patients are defined by previous life threatening major thrombotic or severe hemorrhagic complication or age > 60. Those patients probably benefit from cytoreductive therapy. On the other hand, antiplatelet drugs are recommended for patients with low risk group. Although rare, ET should be considered in the differential diagnosis of persistent thrombocytosis in children, even at a very young age. A constellation of clinical, pathologic ,and molecular testing are essential for diagnosis. Given the rarity of these cases, there is currently no consensus for treatment guidelines in children, especially in asymptomatic patients. We describe a case of a two-year old girl who presented with unexplained, isolated thrombocytosis which persisted for eight years. Bone marrow biopsy demonstrated typical features of ET. Over the course of the disease, hydroxyurea, but not aspirin, showed better control of symptoms and lowered the platelets level.

  4. Two year follow-up of a garbage collector with allergic bronchopulmonary aspergillosis (ABPA).

    Science.gov (United States)

    Allmers, H; Huber, H; Baur, X

    2000-04-01

    Separate collection of biodegradable garbage and recyclable waste is expected to become mandatory in some western countries. A growing number of persons engaged in garbage collection and separation might become endangered by high loads of bacteria and fungi. Case history and examination A 29 year old garbage collector involved in emptying so-called biological garbage complained of dyspnea, fever, and flu-like symptoms during work beginning in the summer of 1992. Chest x-ray showed streaky shadows near both hili reaching into the upper regions. IgE- and IgG-antibodies (CAP, Pharmacia, Sweden) were strongly positive for Aspergillus fumigatus with 90.5 kU/L and 186%, respectively. Total-IgE was also strongly elevated with 5430 kU/L. Bronchial challenge testing with commercially available Aspergillus fumigatus extract resulted in an immediate-type asthmatic reaction. Two years later he was still symptomatic and antibodies persisted at lower levels. Our diagnosis was allergic bronchopulmonary aspergillosis (ABPA) including asthmatic responses as well as hypersensitivity pneumonitis (extrinsic allergic alveolitis) due to exposure to moldy household waste. A growing number of persons engaged in garbage collection and handling are exposed and at risk to develop sensitization to fungi due to exposure to dust of biodegradable waste. Further studies are necessary to show if separate collection of biodegradable waste increases the health risks due to exposure to bacteria and fungi in comparison to waste collection without separation. Copyright 2000 Wiley-Liss, Inc.

  5. Cognitive outcome and reliable change indices two years following bilateral subthalamic nucleus deep brain stimulation.

    Science.gov (United States)

    Williams, Amy E; Arzola, Gladys Marina; Strutt, Adriana M; Simpson, Richard; Jankovic, Joseph; York, Michele K

    2011-06-01

    Subthalamic nucleus deep brain stimulation (STN-DBS) is currently the treatment of choice for medication-resistant levodopa-related motor complications in patients with Parkinson's disease (PD). While STN-DBS often results in meaningful motor improvements, consensus regarding long-term neuropsychological outcome continues to be debated. We assessed the cognitive outcomes of 19 STN-DBS patients compared to a group of 18 medically-managed PD patients on a comprehensive neuropsychological battery at baseline and two years post-surgery. Patients did not demonstrate changes in global cognitive functioning on screening measures. However, neuropsychological results revealed impairments in nonverbal recall, oral information processing speed, and lexical and semantic fluency in STN-DBS patients compared to PD controls 2 years post-surgery in these preliminary analyses. Additionally, reliable change indices revealed that approximately 50% of STN-DBS patients demonstrated significant declines in nonverbal memory and oral information processing speed compared to 25-30% of PD controls, and 26% of STN-DBS patients declined on lexical fluency compared to 11% of PD patients. Approximately 30% of both groups declined on semantic fluency. The number of STN-DBS patients who converted to dementia 2 years following surgery was not significantly different from the PD participants (32% versus 16%, respectively). Our results suggest that neuropsychological evaluations may identify possible mild cognitive changes following surgery. Copyright © 2011 Elsevier Ltd. All rights reserved.

  6. An electrical load measurements dataset of United Kingdom households from a two-year longitudinal study.

    Science.gov (United States)

    Murray, David; Stankovic, Lina; Stankovic, Vladimir

    2017-01-05

    Smart meter roll-outs provide easy access to granular meter measurements, enabling advanced energy services, ranging from demand response measures, tailored energy feedback and smart home/building automation. To design such services, train and validate models, access to data that resembles what is expected of smart meters, collected in a real-world setting, is necessary. The REFIT electrical load measurements dataset described in this paper includes whole house aggregate loads and nine individual appliance measurements at 8-second intervals per house, collected continuously over a period of two years from 20 houses. During monitoring, the occupants were conducting their usual routines. At the time of publishing, the dataset has the largest number of houses monitored in the United Kingdom at less than 1-minute intervals over a period greater than one year. The dataset comprises 1,194,958,790 readings, that represent over 250,000 monitored appliance uses. The data is accessible in an easy-to-use comma-separated format, is time-stamped and cleaned to remove invalid measurements, correctly label appliance data and fill in small gaps of missing data.

  7. Proposed diagnosis criteria for inflicted head injury of children younger than two years of age

    International Nuclear Information System (INIS)

    Fujiwara, Takeo; Okuyama, Makiko; Matsumoto, Tsutomu; Aritaki, Kentarou; Yotani, Nobuyuki; Miyasaka, Mikiko; Nishina, Sachiko

    2008-01-01

    It is difficult to distinguish whether children's head injuries are due to physical abuse or unintentional accidents. However, in the literature, medical findings specific to infant physical abuse were identified. Thus, we developed diagnostic criteria for inflicted head injury (IHI) and assessed its validity. Subjects were collected from all patients who were less than two years old when they visited National Center for Child Health (NCCHD) and Development and underwent head CT scan to assess head trauma from March 1, 2002 to December 31, 2005. Diagnostic criteria for IHI were developed based on definitions of Duhaime et al (1992) and Reece et al (2001). Validity of diagnosis criteria was assessed by comparing the official report to the Child Guidance Center (CGC) from NCCHD to the disposition decided by the CGC. Two-hundred and sixty cases were collected and diagnosed. There was a 86.5% match of the number of cases which were diagnosed as IHI or non-IHI using the IHI diagnostic criteria with official reports to CGC from NCCHD. Among the cases which were diagnosed as presumptive IHI and also reported to the CGC, 20 cases (83.3%) were regarded as abused cases by the CGC. The diagnostic criteria for IHI were valid and would be useful for pediatricians not to condone inflicted head injury. (author)

  8. Two-year review of an on-line accountability system

    International Nuclear Information System (INIS)

    Carlson, R.L.; Bair, W.J.; Larson, G.F.; Serier, M.N.; Woehle, B.A.

    1983-05-01

    In November 1980, Westinghouse Hanford Company installed the initial version of the Safeguards Active Response Inventory System (SARIS). It was designed as an advanced accountability system to meet the needs of process, safeguards, criticality, safety, and inventory control. A single database translates information about a quantity of nuclear material into the language used by process operators or accountants. Modifications made through functions that model the process automatically generate changes in nuclear material reports, including input of transactions to the NMMSS system at Oak Ridge, Tennessee. During the past two years, the user attitude about SARIS has improved, largely due to the changes implemented in four major additions. Problems encountered during development include: obtaining accurate and complete data to load the database, slow computer response, insufficient training of users before system implementation, and functions that did not exactly meet the user's needs. The benefits of SARIS have included: consistency in data reporting, fewer errors due to immediate resolution of discrepancies, a standardized audit trail, and elimination of manual methods. The most important improvement is a reporting scheme that enables rapid conduction and reconciliation of physical inventories

  9. Nonpigmented Metastatic Melanoma in a Two-Year-Old Girl: A Serious Diagnostic Dilemma

    Science.gov (United States)

    Diniz, Gulden; Tosun Yildirim, Hulya; Yamaci, Selcen

    2015-01-01

    Although rare, malignant melanoma may occur in children. Childhood melanomas account for only 0.3–3% of all melanomas. In particular the presence of congenital melanocytic nevi is associated with an increased risk of development of melanoma. We herein report a case of malignant melanoma that developed on a giant congenital melanocytic nevus and made a metastasis to the subcutaneous tissue of neck in a two-year-old girl. The patient was hospitalized for differential diagnosis and treatment of cervical mass with a suspicion of hematological malignancy, because the malignant transformation of congenital nevus was not noticed before. In this case, we found out a nonpigmented malignant tumor of pleomorphic cells after the microscopic examination of subcutaneous lesion. Nonpigmented metastatic melanoma was diagnosed by several immunohistochemical and flow cytometric studies. She was offered palliative chemotherapy; however, her parents did not accept treatment. The patient died within 9 months of diagnosis. We emphasized here that the possibility of malignant melanoma in the differential diagnosis of childhood tumors should be kept in mind. PMID:25763285

  10. Two-year prospective study of major depressive disorder in HIV-infected men.

    Science.gov (United States)

    Atkinson, J Hampton; Heaton, Robert K; Patterson, Thomas L; Wolfson, Tanya; Deutsch, Reena; Brown, Stephen J; Summers, J; Sciolla, A; Gutierrez, R; Ellis, Ronald J; Abramson, Ian; Hesselink, John R; McCutchan, J Allen; Grant, Igor

    2008-06-01

    The risks and factors contributing to major depressive episodes in HIV infection remain unclear. This 2-year prospective study compared cumulative rates and predictors of a major depressive episode in HIV-infected (HIV+) men (N=297) and uninfected (HIV-) risk-group controls (N=90). By design participants at entry were without current major depression, substance dependence or major anxiety disorder. Standardized neuromedical, neuropsychological, neuroimaging, life events, and psychiatric assessments (Structured Clinical Interview for DSM III-R) were conducted semi-annually for those with AIDS, and annually for all others. Lifetime prevalence of major depression or other psychiatric disorder did not differ at baseline between HIV+ men and controls. On a two-year follow-up those with symptomatic HIV disease were significantly more likely to experience a major depressive episode than were asymptomatic HIV+ individuals and HIV-controls (pdepression. After baseline disease stage and medical variables associated with HIV infection were controlled, a lifetime history of major depression, or of lifetime psychiatric comorbidity (two or more psychiatric disorders), predicted subsequent major depressive episode (pdepressive episode. Research cohort of men examined before era of widespread use of advanced anti-HIV therapies. Symptomatic HIV disease, but not HIV infection itself, increases intermediate-term risk of major depression. Prior psychiatric history most strongly predicted future vulnerability.

  11. A Two-Year Prospective Analysis of Mandibular Fractures in Western Population of Maharashtra, India

    Directory of Open Access Journals (Sweden)

    Ashwinirani Suragimath

    2017-01-01

    Full Text Available Introduction: Trauma to the facial region causes injuries to hard and soft tissues of the face. Injuries to the maxillofacial region are increasing in frequency and severity because of the increased number of road traffic accidents (RTAs and increased number of violence. The purpose of this study was to evaluate age, gender distribution, etiology, and pattern of mandibular fractures in Western part of Maharashtra population. Materials and Methods: The study was conducted in the Department of Oral Medicine and Radiology for a period of two years from June 2013 to June 2015. Clinical examination of all trauma patients was done and diagnosis was made based on signs, clinical features, and confirmed by orthopantomographs. Results: Totally, 193 patients were detected with different types of mandibular fractures. Study group involved 77.2% males and 22.8% females with a male to female ratio of 3.3:1. Majority of patients were in the age group of 21–30 years followed by 31–40 years. Trauma due to RTAs were more common followed by assaults and fall. Parasymphyseal fractures were most common type followed by condylar fracture and fracture of angle of mandible. Conclusion: Males were most commonly affected by trauma than females with a predominant age group of 21–30 years. Majority of trauma were due to RTAs with parasymphyseal as most common type of fracture.

  12. Two-year-olds with autism orient to nonsocial contingencies rather than biological motion

    Science.gov (United States)

    Klin, Ami; Lin, David J.; Gorrindo, Phillip; Ramsay, Gordon; Jones, Warren

    2009-01-01

    Typically-developing human infants preferentially attend to biological motion within the first days of life1. This ability is highly conserved across species2,3 and is believed to be critical for filial attachment and for detection of predators4. The neural underpinnings of biological motion perception are overlapping with brain regions involved in perception of basic social signals such as facial expression and gaze direction5, and preferential attention to biological motion is seen as a precursor to the capacity for attributing intentions to others6. However, in a serendipitous observation7, we recently found that an infant with autism failed to recognize point-light displays of biological motion but was instead highly sensitive to the presence of a non-social, physical contingency that occurred within the stimuli by chance. This observation raised the hypothesis that perception of biological motion may be altered in children with autism from a very early age, with cascading consequences for both social development and for the lifelong impairments in social interaction that are a hallmark of autism spectrum disorders8. Here we show that two-year-olds with autism fail to orient towards point-light displays of biological motion, and that their viewing behavior when watching these point-light displays can be explained instead as a response to non-social, physical contingencies physical contingencies that are disregarded by control children. This observation has far-reaching implications for understanding the altered neurodevelopmental trajectory of brain specialization in autism9. PMID:19329996

  13. ANTI-IGE THERAPY FOR SEVERE ASTHMA IN CHILDREN: TWO-YEAR TRIAL

    Directory of Open Access Journals (Sweden)

    T.Yu. Kulichenko

    2010-01-01

    Full Text Available The article summarizes a two-year experience of treating children and adolescents with severe uncontrolled atopic asthma using Omalizumab. This treatment facilitated to achieve full asthma control in 70% of patients and partial control in 30% of patients. Anti-Ig Etherapy contributes to reduce the frequency of asthma relapses 77%, and the number of those seeking emergency medical treatment, particularly no need for in-patient asthma care. Thanks to treatment, lung function parameters improve, particularly in children with low bronchial patency parameters even after administration of broncholytics. Thanks to treatment with omalizumab, the dosage of inhalant glucocorticosteroids is reduced 1.5 to 2.5 times in 75% patients. Treatment tolerance in all children is satisfactory, no serious adverse events associated with the medication or any system side effects are registered in patients. Anti-IgE therapy is a good alternative to use of high and ultra-high doses of inhalant glucocorticosteroids in children with severe atopic asthma. Key words: omalizumab, anti-IgE-antibodies, treatment-resistant asthma, atopic asthma, treatment, children, adolescents, asthma control. (Pediatric Pharmacology. – 2010; 7(3:57-65

  14. Effect of North Carolina's restriction on teenage driver cell phone use two years after implementation.

    Science.gov (United States)

    Goodwin, Arthur H; O'Brien, Natalie P; Foss, Robert D

    2012-09-01

    A majority of states now restrict teenagers from using a mobile communication device while driving. The effect of these restrictions is largely unknown. In a previous study, we found North Carolina's teenage driver cell phone restriction had little influence on young driver behavior four months after the law took effect (Foss et al., 2009). The goal of the present study was to examine the longer-term effect of North Carolina's cell phone restriction. It was expected that compliance with the restriction would increase, as awareness of the restriction grew over time. Teenagers were observed at high schools in North Carolina approximately two years after the law was implemented. Observations were also conducted in South Carolina, which did not have a cell phone restriction. In both states, there was a broad decrease in cell phone use. A logistic regression analysis showed the decrease in cell phone use did not significantly differ between the two states. Although hand-held cell phone use decreased, there was an increase in the likelihood that drivers in North Carolina were observed physically manipulating a phone. Finally, a mail survey of teenagers in North Carolina showed awareness for the cell phone restriction now stands at 78% among licensed teens. Overall, the findings suggest North Carolina's cell phone restriction has had no long-term effect on the behavior of teenage drivers. Moreover, it appears many teenage drivers may be shifting from talking on a phone to texting. Copyright © 2012 Elsevier Ltd. All rights reserved.

  15. An electrical load measurements dataset of United Kingdom households from a two-year longitudinal study

    Science.gov (United States)

    Murray, David; Stankovic, Lina; Stankovic, Vladimir

    2017-01-01

    Smart meter roll-outs provide easy access to granular meter measurements, enabling advanced energy services, ranging from demand response measures, tailored energy feedback and smart home/building automation. To design such services, train and validate models, access to data that resembles what is expected of smart meters, collected in a real-world setting, is necessary. The REFIT electrical load measurements dataset described in this paper includes whole house aggregate loads and nine individual appliance measurements at 8-second intervals per house, collected continuously over a period of two years from 20 houses. During monitoring, the occupants were conducting their usual routines. At the time of publishing, the dataset has the largest number of houses monitored in the United Kingdom at less than 1-minute intervals over a period greater than one year. The dataset comprises 1,194,958,790 readings, that represent over 250,000 monitored appliance uses. The data is accessible in an easy-to-use comma-separated format, is time-stamped and cleaned to remove invalid measurements, correctly label appliance data and fill in small gaps of missing data.

  16. Assessing Student-Mentor Interaction During a Summer REU for Two Year College Students

    Science.gov (United States)

    Doser, D. I.; Olivarez, A.; Rohrbaugh, R.; Villalobos, J. I.

    2017-12-01

    UTEP-ROCCS (Research Opportunities for Community College Students) is a summer REU program designed exclusively for two-year college students. The program differs from other summer REU's in several ways. First, the participants are only in El Paso during the month of June to begin their research projects, with subsequent research carried out at their home institutions with intensive virtual mentoring in July. Second, the mentoring team is a unique mix of 2-year and 4-year college faculty and undergraduate juniors and seniors. Our first cohort of 6 ROCCS students began their research in June 2017 supported by 2 UTEP undergraduate mentors and 5 faculty mentors. Preliminary results of a series of 4 weekly road checks indicate that 95% of the time the participants felt the faculty and student mentors were supportive, encouraging, and able to respond to their questions and concerns. All felt they received constructive, useful critiques of their field and research work, were motivated by the mentors to learn more and were challenged to extend their abilities and skills for the success of their research projects. Over 70% of the time they felt the mentors encouraged them by suggesting appropriate and available resources when they were struggling. And, most importantly, over 96% of the time they felt the experience stimulated their interest in geology as a future career. We hope to observe similar trends in the road checks of July 2017 as participants prepare their results for the AGU's fall virtual undergraduate poster session.

  17. Surface air concentration and deposition of lead-210 in French Guiana: two years of continuous monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Melieres, Marie-Antoinette E-mail: melieres@glaciog.ujf-grenoble.fr; Pourchet, Michel; Richard, Sandrine

    2003-07-01

    To make up for the lack of data on {sup 210}Pb aerosol deposition in tropical regions and to use this radionuclide as an aerosol tracer,a monitoring station was run for two years at Petit-Saut, French Guiana. Lead-210 concentration in air at ground level was monitored continuously together with atmospheric total deposition. The air concentration has a mean value of 0.23{+-}0.02 mBq m{sup -3} during both wet and dry seasons, and it is only weakly affected by the precipitation mechanism. This result was unexpected in a wet tropical region, with a high precipitation rate. In contrast, deposition clearly correlates with precipitation for low/moderate rainfall (<15 cm per 15-day), while this correlation is masked by strong fluctuations at high rainfall. The estimated mean annual deposition over the last ten years is 163{+-}75 Bq m{sup -2} y{sup -1}. This provides a procedure fo estimating this mean flux at other sites in French Guiana.

  18. Chemical and microbiological studies on petroleum contaminated soils after two years of biotreatment

    International Nuclear Information System (INIS)

    Bosecker, K.; Hollerbach, A.; Teschner, M.; Wehner, H.; Kassner, H.

    1993-01-01

    For reclamation of a former refinery area, five batches of 200--300 m 3 of contaminated soil were treated with indigenous or specially selected microorganisms. Partly, the beds were irrigated, nutrients were added or the test sites were heated. After two years of bioremediation soil samples were investigated by chemical and microbiological techniques. Within the period the total concentration of hydrocarbons decreased from 15,000--35,000 mg/kg weight to 3,750--9,400 mg/kg dry weight. The portion of saturated hydrocarbons was reduced by 20--60%. In parallel, the amount of heterocompounds and asphaltenes increased. Polycyclic aromatic hydrocarbons were in the range of 16--31 mg/kg dry weight, phenols were 130--170 μg/kg dry weight. Microbiological investigations resulted in a roughly similar distribution pattern of ecophysiological groups in all samples. Among the heterotrophic aerobes which ranged from 1.2 x 10 7 -- 1.2 x 10 8 cfu/ml oil degrading bacteria predominated (up to 9.4 x 10 7 cells/ml) showing high potential for degradation of saturated hydrocarbons under laboratory conditions

  19. Memory by association: Integrating memories prolongs retention by two-year-olds.

    Science.gov (United States)

    Hayne, Harlene; Gross, Julien

    2017-02-01

    Recalling one memory often leads to the recollection of other memories that share overlapping features. This phenomenon, spreading activation, was originally documented in studies conducted with verbal adults, and more recently, it has been demonstrated with preverbal infants. Here, we examine the effect of spreading activation on long-term retention by 2-year-olds. Participants were tested in the Visual Recognition Memory (VRM) paradigm and the deferred imitation paradigm. Typically, infants of this age exhibit retention in the VRM paradigm for 24h, while they exhibit retention in the deferred imitation paradigm for at least 8 weeks. In the present experiment, we paired these tasks together during original encoding and tested infants after an 8-week delay. Two-year-olds exhibited retention in both tasks. That is, when these two tasks initially occurred together - one task that is extremely memorable and one that is not - retrieving the memory of the more memorable task cued retrieval of the less memorable task, extending its longevity. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. The first two years of electromagnetic follow-up with advanced LIGO and Virgo

    International Nuclear Information System (INIS)

    Singer, Leo P.; Price, Larry R.; Farr, Ben; Urban, Alex L.; Pankow, Chris; Downes, Tom; Vitale, Salvatore; Veitch, John; Farr, Will M.; Haster, Carl-Johan; Mandel, Ilya; Sidery, Trevor; Vecchio, Alberto; Hanna, Chad; Cannon, Kipp; Graff, Philip

    2014-01-01

    We anticipate the first direct detections of gravitational waves (GWs) with Advanced LIGO and Virgo later this decade. Though this groundbreaking technical achievement will be its own reward, a still greater prize could be observations of compact binary mergers in both gravitational and electromagnetic channels simultaneously. During Advanced LIGO and Virgo's first two years of operation, 2015 through 2016, we expect the global GW detector array to improve in sensitivity and livetime and expand from two to three detectors. We model the detection rate and the sky localization accuracy for binary neutron star (BNS) mergers across this transition. We have analyzed a large, astrophysically motivated source population using real-time detection and sky localization codes and higher-latency parameter estimation codes that have been expressly built for operation in the Advanced LIGO/Virgo era. We show that for most BNS events, the rapid sky localization, available about a minute after a detection, is as accurate as the full parameter estimation. We demonstrate that Advanced Virgo will play an important role in sky localization, even though it is anticipated to come online with only one-third as much sensitivity as the Advanced LIGO detectors. We find that the median 90% confidence region shrinks from ∼500 deg 2 in 2015 to ∼200 deg 2 in 2016. A few distinct scenarios for the first LIGO/Virgo detections emerge from our simulations.

  1. Development of early communication skills in the first two years of life.

    Science.gov (United States)

    Beuker, Karin T; Rommelse, Nanda N J; Donders, Rogier; Buitelaar, Jan K

    2013-02-01

    The first two years of life is a crucially important period for the development of communication skills. In this study joint attention and language development were monthly assessed between 8 and 24 months of age in a sample of 23 typically developing children to establish the developmental trajectory of specific joint attention skills, to investigate the developmental interrelations of these different joint attention skills with vocabulary size, and to examine whether the order of development of following and directing attention influences the development of other early communication skills such as language. All joint attention skills emerged between 8 and 15 months of age and responsive joint attention skills tend to emerge before initiative joint attention. Early joint attention skills influenced later language development, but not the other way around. Children in whom directing attention with gaze alternation developed early (in age or order) showed a relatively larger early vocabulary growth. A fine grained mapping of the normal development of early communication skills can be helpful in the early detection of abnormalities in these skills. Copyright © 2012 Elsevier Inc. All rights reserved.

  2. Two-year-olds exclude novel objects as potential referents of novel words based on pragmatics.

    Science.gov (United States)

    Grassmann, Susanne; Stracke, Marén; Tomasello, Michael

    2009-09-01

    Many studies have established that children tend to exclude objects for which they already have a name as potential referents of novel words. In the current study we asked whether this exclusion can be triggered by social-pragmatic context alone without pre-existing words as blockers. Two-year-old children watched an adult looking at a novel object while saying a novel word with excitement. In one condition the adult had not seen the object beforehand, and so the children interpreted the adult's utterance as referring to the gazed-at object. In another condition the adult and child had previously played jointly with the gazed-at object. In this case, children less often assumed that the adult was referring to the object but rather they searched for an alternative referent--presumably because they inferred that the gazed-at object was old news in their common ground with the adult and so not worthy of excited labeling. Since this inference based on exclusion is highly similar to that underlying the Principle of Contrast/Mutual Exclusivity, we propose that this principle is not purely lexical but rather is based on children's understanding of how and why people direct one another's attention to things either with or without language.

  3. The Quest CCS Project - MMV Technology Deployment Through Two Years of Operation

    Science.gov (United States)

    O'Brien, S.

    2017-12-01

    In September 2012, Shell, on behalf of the Athabasca Oil Sands Project venture (Shell Canada Energy, Chevron Canada Limited, Marathon Oil Canada Corporation), announced that it was proceeding to construct the Quest Carbon Capture and Storage (CCS) project near Fort Saskatchewan. Quest is the world's first large-scale commercial application of CCS at an oil sands operation, and it is now capturing more than one million tonnes of CO2 per year from the Scotford Upgrader. It is a fully integrated project, involving CO2 capture at the bitumen upgrader, transportation along a 65 km pipeline, and CO2 storage in a deep saline aquifer (the Basal Cambrian Sands). Construction was completed in August 2015, and the Quest project was certified for commercial operation in September 2015. The Measurement, Monitoring and Verification (MMV) program for Quest is comprehensive, with a variety of technologies being used to monitor the atmosphere, hydrosphere, biosphere and geosphere. These include a Lightsource system for atmospheric monitoring, extensive groundwater sampling, DAS VSPs to assess the development of the CO2 plume, a microseismic array to measure any induced seismic activity, and temperature and pressure gauges for reservoir monitoring. Over two years of operations, this program has been optimized to address key risks while improving operational efficiency. Quest has now successfully captured and stored more than 2 million tonnes of CO2 with no MMV indications of any storage issues.

  4. A two-year review of an on-line accountability system

    International Nuclear Information System (INIS)

    Carlson, R.L.; Bair, W.J.; Larson, G.F.; Serier, M.N.; Woehle, B.A.

    1983-01-01

    In November 1980, Westinghouse Hanford Company installed the initial version of the Safeguards Active Response Inventory System (SARIS). It was designed as an advanced accountability system to meet the needs of process, safeguards, criticality, safety, and inventory control. A single database translates information about a quantity of nuclear material into the language used by process operators or accountants. Modifications made through functions that model the process automatically generate changes in nuclear material reports, including input of transactions to the NMMSS system at Oak Ridge, Tennessee. During the past two years, the user attitude about SARIS has improved, largely due to the changes implemented in four major additions. Problems encountered during development include: obtaining accurate and complete data to load the database, slow computer response, insufficient communication between users and developers, insufficient training of users before system implementation, and functions that did not exactly meet the user's needs. The benefits of SARIS have included: consistency in data reporting, fewer errors due to immediate resolution of discrepancies, a standardized audit trail, and elimination of manual methods. The most important improvement is a reporting scheme that enables rapid conduction and reconciliation of physical inventories

  5. A Tale of Ambivalence: Salman Rushdie's "Two Years, Eight Months and Twenty-Eight Nights"

    Directory of Open Access Journals (Sweden)

    Tarik Ziyad Gulcu

    2017-09-01

    Full Text Available Salman Rushdie’s memoirs, essays and novels contribute to the appreciation of the contradictions in his outlook on life. His experiences in his family enable Rushdie to make efforts for objective and tolerant judgement of British lifestyle and culture. However, his isolation from the society in Britain despite his struggle for adaptation to British cultural values cause contradictions in his cultural identity. While Rushdie expresses his allegiance to India and its culture in The Ground Beneath Her Feet (1999, he reflects his alienation from his homeland in this novel as well. Similarly, in his Imaginary Homelands (1981-1991 whereas Rushdie questions the injustice and inequality caused by imperialism in The New Empire within Britain (1982, he justifies the colonialist discourse in Kipling (1990. He elaborates on the contradictions in his outlook on life in terms of his cultural ambivalence in his fictions such as Midnight’s Children (1981 and Shame (1983. However, in his latest novel, Two Years, Eight Months and Twenty-Eight Nights (2015, Rushdie reflects his cultural identity conflict in terms of rationalism-mysticism dichotomy. With the use of allegory as well as the lack of linearity in time and space, Rushdie justifies his cultural ambivalence in relation to the dynamism of contemporary world. Thus, Rushdie’s latest novel invites reading for its representation of the oppositions in his approach to life.

  6. Review of Online Programming Characteristics and Pricing at Private Not-for-Profit Two Year Colleges in the United States

    Science.gov (United States)

    Ahlstrom, Christopher

    2016-01-01

    Online programming has expanded greatly within higher education and much attention has been spent on public two year colleges (more commonly known as community colleges) and both private and public four year institutions. This research seeks to expand understanding of the small market of private not-for-profit two year colleges within the United…

  7. Two-year results of femtosecond assisted LASIK versus PRK for different severity of astigmatism.

    Science.gov (United States)

    Miraftab, Mohammad; Hashemi, Hassan; Asgari, Soheila

    2018-03-01

    To compare two-year results of femtosecond laser assisted LASIK (femto-LASIK) and photorefractive keratectomy (PRK) in terms of astigmatism correction in patients with less than 2.0 diopters (D) of spherical error and more than 2.0 D of cylinder error. In this retrospective study, data were extracted from 100 patient charts. The two study groups were matched by age, gender, and baseline uncorrected distance visual acuity (UDVA) and refractive astigmatism (RA). Preoperative astigmatism was categorized as mild: 2.00 to LASIK and PRK groups was respectively -3.15 ± 0.94 D (-7.00 to -2.00 D) and -3.29 ± 0.95 D (-6.25 to -2.00 D) at baseline ( P  = 0.284), and -0.61 ± 0.40 D and -0.62 ± 0.60 D one year after surgery ( P  = 0.674), but significantly lower in the femto-LASIK group (-0.61 ± 0.39 vs. -0.83 ± 0.56 D, P  = 0.021) at 2 years when the rate of residual astigmatism more than 1.0 D was 6.3% in the femto-LASIK and 19.6% in the PRK group ( P  = 0.046). Mean UDVA in the femto-LASIK group (0.02 ± 0.05 logMAR) was better than the PRK group (0.06 ± 0.10 logMAR) ( P  = 0.025). Mean corrected distance visual acuity (CDVA) was not significantly different between groups (0.01 ± 0.03 vs. 0.01 ± 0.04 logMAR, P  = 0.714). Both groups had 1-4 Snellen lines CDVA improvement. The three subgroups of baseline astigmatism did not differ significantly in terms of residual astigmatism (all P  > 0.05). However, in subgroups with ≥4.00 D cylinder, there was less astigmatic regression at 1 year in the femto-LASIK group (0.28 ± 0.43 D) than the PRK group (0.54 ± 0.68 D) ( P  = 0.007). Our results pointed to better two-year results with femto-LASIK in the treatment of different degrees of astigmatism. UDVA improvement was superior with femto-LASIK, but the two methods did not significantly differ in terms of CDVA improvement.

  8. The Two-Year Colleges' Role in Building the Future Geoscience Technical Workforce

    Science.gov (United States)

    Wolfe, B.

    2014-12-01

    Careers in energy science related fields represent significant job growth in the U.S. Yet post-secondary career and technical programs have not kept pace with demand and energy science curriculum, including fundamental concepts of energy generation and environmental impact, lacks a firm position among general or career and technical education courses. Many of these emerging energy related jobs are skilled labor and entry level technical positions requiring less than a bachelor's degree. These include jobs such as solar/photovoltaic design and installation, solar water and space heating installation, energy management, efficiency and conservation auditor, environmental technician, etc. These energy related career pathways fit naturally within the geosciences discipline. Many of these jobs can be filled by individuals from HVAC, Industrial technology, welding, and electrical degree programs needing some additional specialized training and curriculum focused on fundamental concepts of energy, fossil fuel exploration and use, atmospheric pollution, energy generation, alternative energy sources, and energy conservation. Two-year colleges (2ycs) are uniquely positioned to train and fill these workforce needs as they already have existing career and technical programs and attract both recent high school graduates, as well as non-traditional students including displaced workers and returning veterans. We have established geoscience related workforce certificate programs that individuals completing the traditional industrial career and technical degrees can obtain to meet these emerging workforce needs. This presentation will discuss the role of geosciences programs at 2ycs in training these new workers, developing curriculum, and building a career/technical program that is on the forefront of this evolving industry.

  9. Two-year mortality, complications, and healthcare use in children with medicaid following tracheostomy.

    Science.gov (United States)

    Watters, Karen; O'Neill, Margaret; Zhu, Hannah; Graham, Robert J; Hall, Matthew; Berry, Jay

    2016-11-01

    To assess patient characteristics associated with adverse outcomes in the first 2 years following tracheostomy, and to report healthcare utilization and cost of caring for these children. Retrospective cohort study. Children (0-16 years) in Medicaid from 10 states undergoing tracheostomy in 2009, identified with International Classification of Diseases, Ninth Revision, Clinical Modification procedure codes and followed through 2011, were selected using the Truven Health Medicaid Marketscan Database (Truven Health Analytics, Inc., Ann Arbor, MI). Patient demographic and clinical characteristics were assessed with likelihood of death and tracheostomy complication using chi-square tests and logistic regression. Healthcare use and spending across the care continuum (hospital, outpatient, community, and home) were reported. A total of 502 children underwent tracheostomy in 2009, with 34.1% eligible for Medicaid because of disability. Median age at tracheostomy was 8 years (interquartile range 1-16 years), and 62.7% had a complex chronic condition. Two-year rates of in-hospital mortality and tracheostomy complication were 8.9% and 38.8%, respectively. In multivariable analysis, the highest likelihood of mortality occurred in children age tracheostomy complication was in children with a complex chronic condition versus those without a complex chronic condition (OR 3.3; 95% CI, 1.1-9.9). Total healthcare spending in the 2 years following tracheostomy was $53.3 million, with hospital, home, and primary care constituting 64.4%, 9.4%, and 0.5% of total spending, respectively. Mortality and morbidity are high, and spending on primary and home care is small following tracheostomy in children with Medicaid. Future studies should assess whether improved outpatient and community care might improve their health outcomes. 4. Laryngoscope, 126:2611-2617, 2016. © 2016 The American Laryngological, Rhinological and Otological Society, Inc.

  10. Undergraduate Research in Earth Science Classes: Engaging Students in the First Two Years

    Science.gov (United States)

    Mogk, D. W.; Wysession, M. E.; Beauregard, A.; Reinen, L. A.; Surpless, K.; O'Connell, K.; McDaris, J. R.

    2014-12-01

    The recent PCAST report (2012), Engage to Excel, calls for a major shift in instructional modes in introductory (geo)science courses by "replacing standard laboratory courses with discovery-based research courses". An increased emphasis is recommended to engage students in experiments with the possibility of true discovery and expanded use of scientific research courses in the first two years. To address this challenge, the On the Cutting Edge program convened a workshop of geoscience faculty to explore the many ways that true research experiences can be built into introductory geoscience courses. The workshop goals included: consideration of the opportunities, strategies and methods used to provide research experiences for students in lower division geoscience courses; examination of ways to develop students' "geoscience habits of mind" through participation in authentic research activities; exploration of ways that student research projects can be designed to contribute to public science literacy with applications to a range of issues facing humanity; and development of strategies to obtain funding for these research projects, to make these programs sustainable in departments and institutions, and to scale-up these programs so that all students may participate. Access to Earth data, information technology, lab and field-based instrumentation, and field experiences provide unprecedented opportunities for students to engage in authentic research at early stages in their careers. Early exposure to research experiences has proven to be effective in the recruitment of students to the geoscience disciplines, improved retention and persistence in degree programs, motivation for students to learn and increase self-efficacy, improved attitudes and values about science, and overall increased student success. Workshop outcomes include an online collection of tested research projects currently being used in geoscience classes, resources related to effective design

  11. [Hypercholesterolemia reduction in children and adolescents after two years of intervention].

    Science.gov (United States)

    Robledo, Jorge A; Siccardi, Leonardo J; Cosio, Francisco; Rodríguez, María I; Robledo, Pamela; Rojas, Natalia; Lubetkin, Alberto

    2009-12-01

    Hypercholesterolemia, one of the main risk factors for cardiovascular diseases, can be detected since childhood. The early detection and a suitable educational process would allow to generate changes of habits and to decrease its prevalence. In 2003, total cholesterol (TC) > 170 mg/dl was found in 39.2% school children and adolescents, aged 5-17 years, of Jovita, Córdoba. To assess cholesterol levels decrease after an educational process and to analyze the relation between hypercholesterolemia and family history for cardiovascular diseases. Formal and no formal educational intervention was developed for two years, through curricular adaptations, talks, campaigns in radio and TV, graphic press, drama, workshops and leaflets. In 2005, cholesterol level was assessed, along with a survey on changes of nutritional habits and physical activity, and family history. A group of 161 students was assesses in both opportunities. There was a significant reduction in total cholesterol (average 13 mg/dl; p 199 mg/dl, the variations of the averages were: TC= -21 mg/dl, LDL-C= -16 mg/dl. The survey revealed improvements in the habits; family history was positive in 59%, unknown in 14%, and negative in 27%, the last ones had the best response to the intervention. A significant reduction of TC was obtained in the studied population; this may be due to the educational intervention. More than a quarter of the individuals presented negative family history for cardiovascular risk factors. Decrease in TC was proportionally better in this group than in those with positive family history.

  12. Costs of allergic diseases from birth to two years in Finland.

    Science.gov (United States)

    Alanne, S; Maskunitty, A; Nermes, M; Laitinen, K; Pekurinen, M

    2012-10-01

    Costing studies are needed to identify the resources used for treatment and inform payers of the costs incurred. The objectives were to determine the costs of diagnosing and treating atopic dermatitis, food allergy and asthma, and to compare the share of costs to society and to the family during the first two years of life. The data were obtained from an ongoing mother-infant nutrition study. The sample comprised 60 infants who developed allergic disease by the age of 24 months and 56 healthy infants with no allergic disease. The costs included diagnosis and treatment of the allergy, disability allowances, travel expenses and time spent by parents. The median costs per infant were €275 (range 94-1306) for atopic dermatitis, €1408 (163-5408) for asthma, €3182 (628-11195) for food allergy, and €10 (0-619) for the healthy infants due to the suspicion of allergic disease. The highest costs in atopic dermatitis were caused by primary care visits, topical treatments, travel costs and parents' time, and those for food allergy by hospital out-patient care, infant formulae for cow's milk allergy, disability allowances and travel costs. The families paid 43% of the costs arising from atopic dermatitis, 13.6% of those from food allergy and 16.5% of those from asthma. Cow's milk allergy emerged as the most expensive allergic disease, especially for the society, and concurrent asthma in particular further increased the costs. Copyright © 2012 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

  13. The good, the bad, and the ugly, of the two year review cycle

    International Nuclear Information System (INIS)

    Killar, F.

    2004-01-01

    With the adoption of the 1996 Edition of the ''Regulations for the Safe Transport of Radioactive Material'' IAEA began a biennial process for the review and potential modifications of the regulations. IAEA members are currently in the third review cycle; this experience provides a perspective of the benefits, the problems and the discord with this process. This paper presents a perspective of the nuclear industry on these issues. It also includes recommendations to make the process more meaningful and of greater value to all parties that involved. ''The Good'' will focus on the benefits, ''The Bad'' will identify the problems, and ''The Ugly'' will cover the discords. ''The Good'' An effective safety program/procedure includes a provision for periodic review and, if warranted, modifications. The 1996 Edition provides a schedule and a plan for executing that schedule. This provides for a logical review and modification and therefore a plan for keeping the regulations current. ''The Bad'' The benefit of a review of the regulations is lost when it is consumed by minor editorial changes that have minimal positive impact on safety. The use of limited resources to address insignificant changes results in a reduction of resources for safety in other aspects of the transportation area. The two year review should capture these minor changes but the implementation should be deferred until prompted by a significant change requirement or the volume of minor changes warrants a revision of the regulations. ''The Ugly'' The ugly part of the process is the adoption of the changes by the various competent authorities. In some competent authorizes it is a simple dictate that this is the way it will be, while other authorities have a very open public process with public participation and open meetings. The result is there is not uniform adoption of the changes either in timing or in consistency

  14. Multiple sclerosis risk sharing scheme: two year results of clinical cohort study with historical comparator.

    Science.gov (United States)

    Boggild, Mike; Palace, Jackie; Barton, Pelham; Ben-Shlomo, Yoav; Bregenzer, Thomas; Dobson, Charles; Gray, Richard

    2009-12-02

    To generate evidence on the longer term cost effectiveness of disease modifying treatments in patients with relapsing-remitting multiple sclerosis. Prospective cohort study with historical comparator. Specialist multiple sclerosis clinics in 70 centres in the United Kingdom. Patients with relapsing-remitting multiple sclerosis who started treatment from May 2002 to April 2005 under the UK risk sharing scheme. Treatment with interferon beta or glatiramer acetate in accordance with guidelines of the UK Association of British Neurologists. Observed utility weighted progression in disability at two years' follow-up assessed on the expanded disability status scale (EDSS) compared with that expected by applying the progression rates in a comparator dataset, modified for patients receiving treatment by multiplying by the hazard ratio derived separately for each disease modifying treatment from the randomised trials. In the primary per protocol analysis, progression in disability was worse than that predicted and worse than that in the untreated comparator dataset ("deviation score" of 113%; excess in mean disability status scale 0.28). In sensitivity analyses, however, the deviation score varied from -72% (using raw baseline disability status scale scores, rather than applying a "no improvement" algorithm) to 156% (imputing missing data for year two from progression rates for year one). It is too early to reach any conclusion about the cost effectiveness of disease modifying treatments from this first interim analysis. Important methodological issues, including the need for additional comparator datasets, the potential bias from missing data, and the impact of the "no improvement" rule, will need to be addressed and long term follow-up of all patients is essential to secure meaningful results. Future analyses of the cohort are likely to be more informative, not least because they will be less sensitive to short term fluctuations in disability.

  15. Regional Brain Shrinkage over Two Years: Individual Differences and Effects of Pro-Inflammatory Genetic Polymorphisms

    Science.gov (United States)

    Persson, N.; Ghisletta, P.; Dahle, C.L.; Bender, A.R.; Yang, Y.; Yuan, P.; Daugherty, A.M.; Raz, N.

    2014-01-01

    We examined regional changes in brain volume in healthy adults (N = 167, age 19-79 years at baseline; N = 90 at follow-up) over approximately two years. With latent change score models, we evaluated mean change and individual differences in rates of change in 10 anatomically-defined and manually-traced regions of interest (ROIs): lateral prefrontal cortex (LPFC), orbital frontal cortex (OF), prefrontal white matter (PFw), hippocampus (HC), parahippocampal gyrus (PhG), caudate nucleus (Cd), putamen (Pt), insula (In), cerebellar hemispheres (CbH), and primary visual cortex (VC). Significant mean shrinkage was observed in the HC, CbH, In, OF, and the PhG, and individual differences in change were noted in all regions, except the OF. Pro-inflammatory genetic variants mediated shrinkage in PhG and CbH. Carriers of two T alleles of interleukin-1β (IL-1βC-511T, rs16944) and a T allele of methylenetetrahydrofolate reductase (MTHFRC677T, rs1801133) polymorphisms showed increased PhG shrinkage. No effects of a pro-inflammatory polymorphism for C-reactive protein (CRP-286C>A>T, rs3091244) or apolipoprotein (APOE) ε4 allele were noted. These results replicate the pattern of brain shrinkage observed in previous studies, with a notable exception of the LPFC thus casting doubt on the unique importance of prefrontal cortex in aging. Larger baseline volumes of CbH and In were associated with increased shrinkage, in conflict with the brain reserve hypothesis. Contrary to previous reports, we observed no significant linear effects of age and hypertension on regional brain shrinkage. Our findings warrant further investigation of the effects of neuroinflammation on structural brain change throughout the lifespan. PMID:25264227

  16. Progressive numbness of distal limbs for two years, unsteady gait for two months

    Directory of Open Access Journals (Sweden)

    Jun MA

    2016-11-01

    Full Text Available A 50-year-old female was admitted to our department, complaining of progressive numbness of distal limbs for two years and unsteady gait for two months. “Peripheral neuropathy” was the presumed diagnosis. She has suffered dry mouth for months. Neurological examination revealed proximal upper muscle strength was normal and distal was 5-/5 while muscle strength in lower limbs was normal. Tendon reflexes in all limbs were reduced, and superficial sensation as well as deep sensation in all limbs was also diminished. Deep sensation below T8-10 was diminished. Romberg’s test was positive with negative pathological reflex. Several sensory nerves action potentials (SNAPs were diminished or absent with normal compound muscle action potentials (CMAPs. Cervical MRI showed hyperintensities in the dorsal column. Serum anti-Ro/SSA antibody was positive. Tear break-up time was abnormal in either eye (5s, normal range>10s; the rate of saliva production declined 0.02 ml/min (> 1.50 ml/15 min; parotid gland contrast sialography was abnormal; lip biopsy was positive with focal lymphocytic sialadenitis with focus score ≥1. The patient was diagnosed as primary Sjogren's syndrome and sensory neuronopathy. She received oral prednisone in dose of 1mg/(kg·d for four weeks, then reduce the dosage with 5mg/w to 0.50mg/ (kg·d. Later she reduced the dosage with 2.5mg/per week. At the same time, she got cyclophosphamide (100mg every other day and hydroxychloroquine (0.20g twice a day. Numbness of limbs and unsteady gait were improved when the patient was discharged. Two month later, during the follow-up, the patient’ gait was slightly improved, but the numbness still existed. DOI: 10.3969/j.issn.1672-6731.2016.11.016

  17. Two years of outstanding AFGD performance, pure air on the Lakes Bailly Scrubber Facility

    Energy Technology Data Exchange (ETDEWEB)

    Henderson, J.; Vymazal, D.C. [Pure Air, Allentown, PA (United States); Styf, D.A. [Northern Indiana Public Service Company (NIPSCO), Chesterton, IN (United States)] [and others

    1994-12-31

    The {open_quotes}Advanced Flue Gas Desulfurization (AFGD) Demonstration Project{close_quotes} is a $151.3 million cooperative effort between the U.S. Department of Energy and a project company of Pure Air, a general partnership of Air Products and Chemicals, Inc. and Mitsubishi Heavy Industries America, Inc. The goal of the AFGD project is to demonstrate that, by combining state-of-the-art technology, highly efficient plant operation and maintenance capabilities, and by-product gypsum sales, significant reductions of SO{sub 2} emissions can be achieved at approximately one-half the life cycle of a conventional Flue Gas Desulfurization (FGD) system. Further, this emission reduction is achieved without generating solid waste and while minimizing liquid wastewater effluent. Briefly, this project entails the design, construction and operation of a nominal 600 MWe AFGD facility to remove SO{sub 2} from coal-fired power plant flue gas at the Northern Indiana Public Service Company`s Bailly Generating Station, located approximately 40 miles southeast of Chicago, Illinois. The facility is used to demonstrate a variety of advanced technical and business-related features, during a three-year period of operation which began in the summer of 1992. The aim of this demonstration is to accelerate near-term commercialization. Key features of the AFGD project are discussed. Construction of the scrubber is complete; operations began in June 1992, ahead of schedule and within budget. The Clean Coal demonstration project calls for three years of operations. After the three-year demonstration period, Pure Air on the Lake will continue to Own-and-Operate the scrubber for the next 17 years. This paper review the advanced wet flue gas desulfurization (FGD) design features, and the environmental and business features of the project. Also included are data on the first two years of successful operation.

  18. Associations between sports participation and psychological difficulties during childhood: a two-year follow up.

    Science.gov (United States)

    Vella, Stewart A; Cliff, Dylan P; Magee, Christopher A; Okely, Anthony D

    2015-05-01

    This paper assessed the associations between sports participation and the development of psychological strengths and difficulties during childhood. Two-year follow up study of a sample of 4042 Australian children who were followed from age 8 years to 10 years. Parents reported children's participation in organised sports, and completed the Strengths and Difficulties Questionnaire. Univariate general linear models were used to examine the association between changes in sports participation and psychological strengths and difficulties at 10 years, adjusting for psychological strengths and difficulties at age 8. Children who maintained participation in sport had lower rates of parent-reported psychological difficulties at 10 years compared with children who dropped out of sport. Less internalising problems were also reported for children who participated in organised sports compared to children who dropped out of sports and children who did not participate in sports. These relationships did not differ by BMI, socioeconomic status, or parental education. Greater psychological difficulties are experienced by children who drop out of sports, and greater social and emotional problems are experienced by children who drop out of sports and who do not participate in organised sports. Due consideration should be given to the quality and implementation of sporting programs to ensure that they provide benefits to mental health. Due consideration should also be given to the potential psychological difficulties being experienced by children who drop out of organised sports as a higher level of psychological difficulties may be experienced prior to or subsequent to dropout. Copyright © 2014 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  19. Expressive language of two year-old pre-term and full-term children.

    Science.gov (United States)

    Isotani, Selma Mie; Azevedo, Marisa Frasson de; Chiari, Brasília Maria; Perissinoto, Jacy

    2009-01-01

    expressive language of pre-term children. to compare the expressive vocabulary of two year-old children born prematurely, to that of those born at term. the study sample was composed by 118 speech-language assessment protocols, divided in two groups: the pre-term group (PTG) composed by 58 underweight premature children followed by a multi-professional team at the Casa do Prematuro (House of Premature Children) at Unifesp, and the full-term group (FTG) composed by 60 full-term born children. In order to evaluate the expressive language of these children, the Lave - Lista de Avaliação do Vocabulário Expressivo (Assessment List of the Expressive Vocabulary) was used. The Lave is an adaptation of the LDS - Language Development Survey - for the Brazilian Portuguese Language. The Lave investigates the expressive language and detects delays in oral language. children born underweight and prematurely present a greater occurrence of expressive language delay, 27.6%. These pre-term children present significantly lower expressive vocabulary and phrasal extension than children of the same age born at full-term in all semantic categories. Family income proved to be positively associated to phrasal extension, as well as to gestational age and weight at birth; thus indicating the effect of these adverse conditions still during the third year of age. The audiological status was associated to word utterances in the PTG. children born prematurely and underweight are at risk in terms of vocabulary development; this determines the need for speech-therapy intervention programs.

  20. Interdependence of soil and agricultural practice in a two - year phytoremediation in situ experiment

    Science.gov (United States)

    Nwaichi, Eucharia; Onyeike, Eugene; Frac, Magdalena; Iwo, Godknows

    2016-04-01

    A two - year plant - based soil clean - up was carried out at a crude oil spill agricultural site in a Niger Delta community in Nigeria to access further clean - up potentials of Cymbopogon citratus. Applied diagnostic ratios identified mixed petrogenic and pyrogenic sources as the main contributors of PAHs. Up to 90.8% sequestration was obtained for carcinogenic PAHs especially Benz (a) pyrene in a 2 - phase manner. A community level approach for assessing patterns of sole carbon source utilization by mixed microbial samples was employed to differentiate spatial and temporal changes in the soil microbial communities. In relation to pollution, soil conditioning notably decreased the lag times and showed mixed effects for colour development rates, maximum absorbance and the overall community pattern. For rate and utilization of different carbon substrates in BIOLOG wells, after day 3, in comparison to control soil communities, contamination with hydrocarbons and associated types increased amines and amides consumption. Consumption of carbohydrates in all polluted and unamended regimes decreased markedlyin comparison to those cultivated with C. citratus. We found a direct relationship between cellulose breakdown, measurable with B-glucosidase activity, organic matter content and CO2 realease within all soils in the present study. Organic amendment rendered most studied contaminants unavailable for uptake in preference to inorganic fertilizer in both study years. Generally, phytoremediation improved significantly the microbial community activity and thus would promote ecosystem restoration in relation to most patronised techniques. Supplementation with required nutrients, in a long - term design would present many ecological benefits. Keywords: Agricultural soils; Recovery; Hydrocarbon pollution; Ecology; Management practice.

  1. Safety of strength training in premenopausal women: musculoskeletal injuries from a two-year randomized trial.

    Science.gov (United States)

    Warren, Meghan; Schmitz, Kathryn H

    2009-01-01

    The health benefits of strength training must be weighed against risks, including injuries. A prior study observed 4.2 injuries that limited usual activities for a day per 1000 strength training sessions among men and women. The analysis herein explores the incidence rates of musculoskeletal injuries from strength training in women. Randomized controlled trial. SETTING; Free-living community. A total of 163 injury-free, overweight, sedentary, premenopausal women aged 25 to 44 years. Two years of strength training (n = 81) or standard care (n = 82). The intervention followed published guidelines (U.S. Department of Health and Human Services) with hypothesized injury prevention strategies. An injury survey was administered at years 1 and 2. Injury was defined as physical activity or strength training associated injuries that limited daily activities for 1 week or more. Denominators for rate calculation were accelerometer-measured physical activity and strength training attendance (strength training only). The between-group probability of injuries was assessed using generalized estimating equations. Injury incidence rates were higher in strength training compared with standard care. In strength training, the injury rates were 3.6 per 1000 strength training sessions (95% confidence interval: 2.5-4.8 per 1000) for physical activity-related injuries, and 2.6 per 1000 (95% confidence interval: 1.5-3.6 per 1000) for strength training-related injuries. Injury rates varied by definition and denominator. Strength training had lower injury rates than previously reported, providing preliminary support for the prevention strategies. The finding of strength training injuries underscores the need for balancing the benefits against the potential risks of this exercise modality.

  2. Impact of functional and structural social relationships on two year depression outcomes: A multivariate analysis.

    Science.gov (United States)

    Davidson, Sandra K; Dowrick, Christopher F; Gunn, Jane M

    2016-03-15

    High rates of persistent depression highlight the need to identify the risk factors associated with poor depression outcomes and to provide targeted interventions to people at high risk. Although social relationships have been implicated in depression course, interventions targeting social relationships have been disappointing. Possibly, interventions have targeted the wrong elements of relationships. Alternatively, the statistical association between relationships and depression course is not causal, but due to shared variance with other factors. We investigated whether elements of social relationships predict major depressive episode (MDE) when multiple relevant variables are considered. Data is from a longitudinal study of primary care patients with depressive symptoms. 494 participants completed questionnaires at baseline and a depression measure (PHQ-9) two years later. Baseline measures included functional (i.e. quality) and structural (i.e. quantity) social relationships, depression, neuroticism, chronic illness, alcohol abuse, childhood abuse, partner violence and sociodemographic characteristics. Logistic regression with generalised estimating equations was used to estimate the association between social relationships and MDE. Both functional and structural social relationships predicted MDE in univariate analysis. Only functional social relationships remained significant in multivariate analysis (OR: 0.87; 95%CI: 0.79-0.97; p=0.01). Other unique predictors of MDE were baseline depression severity, neuroticism, childhood sexual abuse and intimate partner violence. We did not assess how a person's position in their depression trajectory influenced the association between social relationships and depression. Interventions targeting relationship quality may be part of a personalised treatment plan for people at high risk due of persistent depression due to poor social relationships. Copyright © 2015 Elsevier B.V. All rights reserved.

  3. Family influence on the consumption of sugary drinks by children under two years old.

    Science.gov (United States)

    Jaime, Patricia Constante; Prado, Rogério Ruscitto do; Malta, Deborah Carvalho

    2017-06-01

    To evaluate the influence of family habits and household characteristics on the consumption of sugary drinks by Brazilian children under two years old. This was a cross-sectional study that used secondary data generated by the National Health Survey (PNS) in 2013. We studied 4,839 pairs of children under two years old and adults living in the same house. We estimated the prevalence of the indicator of sugary drinks consumption for the total sample of children and according to family and household variables. We applied multiple logistic regression analysis to evaluate the influence of family habits and household characteristics on the consumption of sugary drinks by the children. The consumption of sugary drinks was identified in 32% of the studied children (95%CI 30.6-33.3) and was independently associated with the following family and household characteristics: regular consumption of sugary drinks by the adult living in the house (OR = 1.78; 95%CI 1.51-2.10), watching TV for more than three hours per day (OR = 1.22; 95%CI 1.03-1.45), older age (OR = 3.10; 95%CI 1.54-6.26), greater education level (OR = 0.70; 95%CI 0.53-0.91), house located in the Northeast region (OR = 0.65; 95%CI 1.54-6.26), and number of family members (OR = 1.05; 95%CI 1.00-1.09). Our findings indicate the high prevalence of sugary drinks consumption by Brazilian children under two years old and show that sociodemographic characteristics and family habits affect this feeding practice not recommended in childhood. Avaliar a influência de hábitos familiares e características do domicílio sobre o consumo de bebidas açucaradas em crianças brasileiras menores de dois anos. Estudo transversal que utilizou dados secundários gerados pela Pesquisa Nacional de Saúde (PNS), em 2013. Foram estudados 4.839 pares de crianças menores de dois anos e adultos residentes no mesmo domicílio. Foram estimadas as prevalências do indicador consumo de bebidas açucaradas para a amostra total de crianças e

  4. Emergency Medical Technician Training for Medical Students: A Two-Year Experience.

    Science.gov (United States)

    Blackwell, Thomas H; Halsey, R Maglin; Reinovsky, Jennifer H

    2016-01-01

    New medical school educational curriculum encourages early clinical experiences along with clinical and biomedical integration. The University of South Carolina School of Medicine Greenville, one of the new expansion schools, was established in 2011 with the first class matriculating in 2012. To promote clinical skills early in the curriculum, emergency medical technician (EMT) training was included and begins in the first semester. Along with the early clinical exposure, the program introduces interprofessional health and teams and provides the opportunity for students to personally see and appreciate the wide variety of environments from which their future patients emanate. This report describes the EMT program and changes that were made after the first class that were designed to integrate EMT training with the biomedical sciences and to assess the value of these integrative changes using objective criteria. A two-year retrospective study was conducted that involved the first two classes of medical students. Baseline student data and pass rates from the psychomotor skill and written components of the State examination were used to determine if students performed better in the integrated, prolonged course. There were 53 students in the first class and 54 in the second. Of the 51 students in the first class and 53 students in the second class completing the state psychomotor and written examination, 20 (39%) in the first class and 17 (32%) in the second passed on the initial psychomotor skill attempt; however, more students passed in the first three attempts in the second class than the first class, 51 (96%) versus 45 (88%) , respectively. All students passed by 5 attempts. For the written examination, 50 (98%) students in the first class and 51 (96%) in the second class passed on the first attempt. All students passed by the third attempt. Pass rates on both components of the State examination were not significantly different between classes. Medical students who

  5. Two years of recorded data for a multisource heat pump system: A performance analysis

    International Nuclear Information System (INIS)

    Busato, F.; Lazzarin, R.M.; Noro, M.

    2013-01-01

    housed the same school, which had similar dimensions. -- Highlights: • We monitored an HVAC plant based on multisource heat pump for two years. • The electricity consumptions of auxiliaries (pumps etc) were taken into account. • A detailed first law energy balance of the plant was calculated on a monthly base, as well as a Primary Energy balance. • The use of more than one heat source at the evaporator level increases the efficiency of the heat pumps

  6. Factors related to the economic sustainability of two-year chemistry-based technology training programs

    Science.gov (United States)

    Backus, Bridgid A.

    Two-year chemistry-based technology training (CBTT) programs in the U.S. are important in the preparation of the professional technical workforce. The purpose of this study was to identify, examine, and analyze factors related to the economic sustainability of CBTT programs. A review of literature identified four clustered categories of 31 sub-factors related to program sustainability. Three research questions relating to program sustainability were: (1) What is the relative importance of the identified factors?, (2) What differences exist between the opinions of administrators and faculty?, and (3) What are the interrelationships among the factors? In order to answer these questions, survey data gathered from CBTT programs throughout the United States were analyzed statistically. Conclusions included the following: (1) Rank order of the importance to sustainability of the clustered categories was: (1) Partnerships, (2) Employer and Student Educational Goals, (3) Faculty and Their Resources, and (4) Community Perceptions and Marketing Strategies. (2) Significant correlations between ratings of sustainability and the sub-factors included: degree of partnering, college responsiveness, administration involvement in partnerships, experiential learning opportunities, employer input in curriculum development, use of skill standards, number of program graduates, student job placement, professional development opportunities, administrator support, presence of a champion, flexible scheduling, program visibility, perception of chemical technicians, marketing plans, and promotion to secondary students. (3) Faculty and administrators differed significantly on only two sub-factor ratings: employer assisted curriculum development, and faculty workloads. (4) Significant differences in ratings by small program faculty and administrators and large program faculty and administrators were indicated, with most between small program faculty and large program administrators. The study

  7. Health costs in anthroposophic therapy users: a two-year prospective cohort study

    Directory of Open Access Journals (Sweden)

    Willich Stefan N

    2006-06-01

    Full Text Available Abstract Background Anthroposophic therapies (counselling, special medication, art, eurythmy movement, and rhythmical massage aim to stimulate long-term self-healing processes, which theoretically could lead to a reduction of healthcare use. In a prospective two-year cohort study, anthroposophic therapies were followed by a reduction of chronic disease symptoms and improvement of quality of life. The purpose of this analysis was to describe health costs in users of anthroposophic therapies. Methods 717 consecutive outpatients from 134 medical practices in Germany, starting anthroposophic therapies for chronic diseases, participated in a prospective cohort study. We analysed direct health costs (anthroposophic therapies, physician and dentist consultations, psychotherapy, medication, physiotherapy, ergotherapy, hospital treatment, rehabilitation and indirect costs (sick leave compensation in the pre-study year and the first two study years. Costs were calculated from resource utilisation, documented by patient self-reporting. Data were collected from January 1999 to April 2003. Results Total health costs in the first study year (bootstrap mean 3,297 Euro; 95% confidence interval 95%-CI 3,157 Euro to 3,923 Euro did not differ significantly from the pre-study year (3,186 Euro; 95%-CI 3,037 Euro to 3,711 Euro, whereas in the second year, costs (2,771 Euro; 95%-CI 2,647 Euro to 3,256 Euro were significantly reduced by 416 Euro (95%-CI 264 Euro to 960 Euro compared to the pre-study year. In each period hospitalisation and sick-leave together amounted to more than half of the total health costs. Anthroposophic therapies and medication amounted to 3%, 15%, and 8% of total health costs in the pre-study year, first year, and second study year, respectively. The cost reduction in the second year was largely accounted for by a decrease of inpatient hospitalisation, leading to a hospital cost reduction of 519 Euro (95%-CI 377 Euro to 904 Euro compared to the

  8. Water, soil and soccer: an experience of two years promoting humanistic competences and standardization of curricula

    Science.gov (United States)

    Licciardello, Feliciana; Consoli, Simona; Izquierdo, Guillermo; Parraguirre, Sebastián; Pérez-Palazón, María J.; Pimentel, Rafael; Polo, María J.; Taguas, Encarnación V.

    2015-04-01

    We present an experience of two years where a group of professors of University in Catania (Italy) and the University of Cordoba (Spain) created a practical case about hydrological planning in the context of similar subjects. The proposed work had to be solved and presented by teams of two students who competed following the philosophy of soccer leagues (national and champion). In the final match, the best teams of each country "played" and defended their work which was judged by an international committee of professors. The presentation and defense was carried out through videoconference so the fans in each country could support their teams. The winners in each country received a certificate of both Universities and the participation in the EGU Assembly 2014 and 2015 as coauthors of the present work. The objective of the practical case is the calculation of design peak flow for a rainfall quantile in a rural catchment following the Curve Number method developed by the Soil Conservation Service (1972.) This type of study implies different disciplines of Hydrology and Soil Sciences and the use of Geographic Information Systems and calculation and programming tools which is very useful to improve the students' technical skills. As for humanistic skills, an oral presentation in English allows improving their knowledge in foreign languages and to face a challenging experience which can be compared with an interview for a job. This teaching experience was very motivating for the students and the professors involved. The results of surveys done by the students indicated the improvement of the level of knowledge about hydrological engineering projects as well as the interest in managing water resources. This type of experience can be useful for other subjects or can integrate more teaching centres. REFERENCES: USDA Soil Conservation Service, 1972. National Engineering Handbook, Section 4, Hydrology. US Government Printing Office, Washington, DC, 544. Acknowledment

  9. Arthroscopic subacromial decompression results in normal shoulder function after two years in less than 50% of patients

    DEFF Research Database (Denmark)

    Konradsen, Lars Aage Glud; Jensen, Claus Hjorth

    2015-01-01

    additional resection of the acromioclavicular joint. RESULTS: WORC scores improved significantly from preoperatively (median: 1,392) to three months (median: 204) and two years post-operatively (median: 243) (p

  10. Two-Year Trajectory of Fall Risk in People With Parkinson Disease: A Latent Class Analysis.

    Science.gov (United States)

    Paul, Serene S; Thackeray, Anne; Duncan, Ryan P; Cavanaugh, James T; Ellis, Theresa D; Earhart, Gammon M; Ford, Matthew P; Foreman, K Bo; Dibble, Leland E

    2016-03-01

    To examine fall risk trajectories occurring naturally in a sample of individuals with early to middle stage Parkinson disease (PD). Latent class analysis, specifically growth mixture modeling (GMM), of longitudinal fall risk trajectories. Assessments were conducted at 1 of 4 universities. Community-dwelling participants with PD of a longitudinal cohort study who attended at least 2 of 5 assessments over a 2-year follow-up period (N=230). Not applicable. Fall risk trajectory (low, medium, or high risk) and stability of fall risk trajectory (stable or fluctuating). Fall risk was determined at 6 monthly intervals using a simple clinical tool based on fall history, freezing of gait, and gait speed. The GMM optimally grouped participants into 3 fall risk trajectories that closely mirrored baseline fall risk status (P=.001). The high fall risk trajectory was most common (42.6%) and included participants with longer and more severe disease and with higher postural instability and gait disability (PIGD) scores than the low and medium fall risk trajectories (Pfall risk (posterior probability fall risk trajectories over 2 years. Further investigation is required to determine whether interventions to improve gait and balance may improve fall risk trajectories in people with PD. Copyright © 2016 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  11. Comparison of Intermittent Fasting Versus Caloric Restriction in Obese Subjects: A Two Year Follow-Up.

    Science.gov (United States)

    Aksungar, F B; Sarıkaya, M; Coskun, A; Serteser, M; Unsal, I

    2017-01-01

    Caloric restriction (CR) is proven to be effective in increasing life span and it is well known that, nutritional habits, sleeping pattern and meal frequency have profound effects on human health. In Ramadan some Muslims fast during the day-light hours for a month, providing us a unique model of intermittent fasting (IF) in humans. In the present study, we have investigated the effects of IF versus CR on the same non-diabetic obese subjects who were followed for two years according to the growth hormone (GH)/Insulin like growth factor (IGF)-1 axis and insulin resistance. Single-arm Interventional Human Study. 23 female subjects (Body Mass Index (BMI) 29-39, aged between 28-42years). Follow-up is designed as 12 months of CR, after which there was a month of IF and 11 months of CR again, to be totally 24 months. Subjects' daily diets were aligned as low calorie diet during CR and during the IF period, the same subjects fasted for 15 hours in a day for a month and there was no daily calorie restriction. Nutritional pattern was changed as 1 meal in the evening and a late supper before sleeping and no eating and drinking during the day light hours in the IF model. Subjects made brisk walking twice a day during the whole follow-up including both CR and IF periods. BMI, Blood glucose, insulin, TSH, GH, HbA1c, IGF-1, Homa-IR and urinary acetoacetate levels were monitored once in three months and twice in the fasting month. While subjects lost 1250 ± 372g monthly during the CR, in the IF period, weight loss was decreased to 473 ± 146 g. BMI of all subjects decreased gradually and as the BMI decreased, glucose, HbA1c, insulin, Homa-IR and TSH levels were decreased. GH levels were at baseline at the beginning, increased in the first six months and stayed steady during the CR and IF period than began decreasing after the IF period, while IGF-I increased gradually during the CR period and beginning with the 7th day of IF period, it decreased and kept on decreasing till the

  12. Water Erosion in a Two Year Old Stand of Eucalyptus benthamii under three Plantation Methods

    Science.gov (United States)

    Padilha, J.; Bertol, I.; Marioti, J.; Ramos, J. C.; Flores, M. C.; Tanaka, M. S.; Paz González, A.

    2012-04-01

    The preparation of the soil is the main issue of soil management. Thus, it is also one of the main operations with regard to management of planted forest during the whole productive process. Soil preparation is thought to directly affect various processes of the hydrologic cycle, water erosion, crop productivity and, subsequently, play an important role both for the environment and for the invested capital. Therefore knowledge of the effect of each specific soil management system on forest production is viewed as an essential issue. Based on these considerations, the aim of this work was to quantify soil and water losses by water erosion during the seasons of the year with the highest rainfall intensity in the south hemisphere, i.e. spring and summer in a two year old stand planted with Eucalyptus benthamii. This tree species was planted following three different conditions: 1) soil mechanical preparation in furrows following the land slope, 2) soil mechanical preparation in furrows dug perpendicular to the slope and 3) semi-mechanical preparation by digging an individual hole for each plant. The field experiment was located in Otacílio Costa municipality, SC, Brazil, at the Gropp forest farm owned by the Kablin SA company, 841 m asl altitude. The soil was classified as a "Cambissolo Húmico Alumínico Léptico" according with the Brazilian Soil Classification System with a slope of about 0.12 m m-1. The experimental design consisted of randomly located erosion plots with 3 repetitions, thus a total of 9 plots. The surface area of the plots was 12 x 24 m and they were oriented so that the main side followed the land slope. Suspended sediments and water losses were channelled to collecting tank at the end of the plot. Runoff water and eroded sediments were weakly measured, so that they correspond to cumulative weakly rainfall. The highest soil and water losses were recorded in plots with furrows dug perpendicular to the slope and the lowest ones corresponded to the

  13. Urinary incontinence and vaginal squeeze pressure two years post-cesarean delivery in primiparous women with previous gestational diabetes mellitus

    OpenAIRE

    Barbosa, Angélica Mércia Pascon; Dias, Adriano; Marini, Gabriela; Calderon, Iracema Mattos Paranhos; Witkin, Steven; Rudge, Marilza Vieira Cunha

    2011-01-01

    OBJECTIVE: To assess the prevalence of urinary incontinence and associated vaginal squeeze pressure in primiparous women with and without previous gestational diabetes mellitus two years post-cesarean delivery. METHODS: Primiparous women who delivered by cesarean two years previously were interviewed about the delivery and the occurrence of incontinence. Incontinence was reported by the women and vaginal pressure evaluated by a Perina perineometer. Sixty-three women with gestational diabetes ...

  14. Breastfeeding up to two years of age or beyond and its influence on child growth and development: a systematic review.

    Science.gov (United States)

    Delgado, Carlos; Matijasevich, Alicia

    2013-02-01

    A systematic review was undertaken to identify studies describing the global prevalence of breastfeeding up to two years of age or beyond and its effects on child growth and development. The MEDLINE and LILACS databases were searched without any language or date restrictions, retrieving 3,561 titles. All retrieved titles, 453 abstracts and 49 full-text articles were read. Articles with maximum breastfeeding duration of over two years were included. An analysis was carried out of 19 articles that met the inclusion criteria resulting in a combined prevalence of breastfeeding at two years of age of 33 % (95%CI: 0.23; 0.42). Increasing trends towards breastfeeding up to two years of age or beyond were observed in the past decades in South Asia. The six studies analyzing the effects of breastfeeding up to two years of age or beyond on child growth showed contradictory results. No association was found with child development. It is concluded that evidence on the medium-term effects of breastfeeding up to two years of age or beyond is scarce and contradictory. Hence, further research is needed regarding this practice.

  15. The development of emotion expression during the first two years of life.

    Science.gov (United States)

    Malatesta, C Z; Culver, C; Tesman, J R; Shepard, B

    1989-01-01

    This study examines the course of emotion expression development over the first 2 years of life in a sample of full-term and preterm children. 58 mother/infant pairs were videotaped at infant ages of 2 1/2, 5, 7 1/2, and 22 months, recording face-to-face interaction involving play and separation/reunion sessions. The tapes were coded on a second-to-second basis using Izard's facial affect coding system. Data analysis focused on (1) differences in expressive behavior at 22 months as a function of risk status, gender, attachment status, and patterns of earlier maternal contingency behavior; (2) stability of specific emotional expressive patterns across assessment periods; and (3) the relation of expressive behavior and security of attachment at 2 years to qualities of earlier affective interchange. Mother's contingency behavior (both general level and specific contingency patterns) appeared to have a material effect on the course of emotional development, as did birth status and gender. Prematurity was associated with differential socioemotional development well into the second year, much in contrast to the "catch-up effect" observed in linguistic and cognitive functioning. Discrete emotions analysis of attachment groups yielded differentiation along a broad negative/positive dimension, but it also showed that insecurely attached children can be characterized as showing inhibited anger expression. The results of this study are discussed within the framework of organizational models of infant affective development; attachment theory and discrete emotions approaches were found to yield different yet equally informative data on the course of socioemotional development.

  16. Comparative clinical study of the effectiveness of different dental bleaching methods - two year follow-up

    Directory of Open Access Journals (Sweden)

    Rafael Francisco Lia Mondelli

    2012-08-01

    Full Text Available This study evaluated color change, stability, and tooth sensitivity in patients submitted to different bleaching techniques. MATERIAL AND METHODS: In this study, 48 patients were divided into five groups. A half-mouth design was conducted to compare two in-office bleaching techniques (with and without light activation: G1: 35% hydrogen peroxide (HP (Lase Peroxide - DMC Equipments, São Carlos, SP, Brazil + hybrid light (HL (LED/Diode Laser, Whitening Lase II DMC Equipments, São Carlos, SP, Brazil; G2: 35% HP; G3: 38% HP (X-traBoost - Ultradent, South Jordan UT, USA + HL; G4: 38% HP; and G5: 15% carbamide peroxide (CP (Opalescence PF - Ultradent, South Jordan UT, USA. For G1 and G3, HP was applied on the enamel surface for 3 consecutive applications activated by HL. Each application included 3x3' HL activations with 1' between each interval; for G2 and G4, HP was applied 3x15' with 15' between intervals; and for G5, 15% CP was applied for 120'/10 days at home. A spectrophotometer was used to measure color change before the treatment and after 24 h, 1 week, 1, 6, 12, 18 and 24 months. A VAS questionnaire was used to evaluate tooth sensitivity before the treatment, immediately following treatment, 24 h after and finally 1 week after. RESULTS: Statistical analysis did not reveal any significant differences between in-office bleaching with or without HL activation related to effectiveness; nevertheless the time required was less with HL. Statistical differences were observed between the results after 24 h, 1 week and 1, 6, 12, 18 and 24 months (intergroup. Immediately, in-office bleaching increased tooth sensitivity. The groups activated with HL required less application time with gel. CONCLUSION: All techniques and bleaching agents used were effective and demonstrated similar behaviors.

  17. Lung protective mechanical ventilation and two year survival in patients with acute lung injury: prospective cohort study.

    Science.gov (United States)

    Needham, Dale M; Colantuoni, Elizabeth; Mendez-Tellez, Pedro A; Dinglas, Victor D; Sevransky, Jonathan E; Dennison Himmelfarb, Cheryl R; Desai, Sanjay V; Shanholtz, Carl; Brower, Roy G; Pronovost, Peter J

    2012-04-05

    To evaluate the association of volume limited and pressure limited (lung protective) mechanical ventilation with two year survival in patients with acute lung injury. Prospective cohort study. 13 intensive care units at four hospitals in Baltimore, Maryland, USA. 485 consecutive mechanically ventilated patients with acute lung injury. Two year survival after onset of acute lung injury. 485 patients contributed data for 6240 eligible ventilator settings, as measured twice daily (median of eight eligible ventilator settings per patient; 41% of which adhered to lung protective ventilation). Of these patients, 311 (64%) died within two years. After adjusting for the total duration of ventilation and other relevant covariates, each additional ventilator setting adherent to lung protective ventilation was associated with a 3% decrease in the risk of mortality over two years (hazard ratio 0.97, 95% confidence interval 0.95 to 0.99, P=0.002). Compared with no adherence, the estimated absolute risk reduction in two year mortality for a prototypical patient with 50% adherence to lung protective ventilation was 4.0% (0.8% to 7.2%, P=0.012) and with 100% adherence was 7.8% (1.6% to 14.0%, P=0.011). Lung protective mechanical ventilation was associated with a substantial long term survival benefit for patients with acute lung injury. Greater use of lung protective ventilation in routine clinical practice could reduce long term mortality in patients with acute lung injury. Clinicaltrials.gov NCT00300248.

  18. Internationally Adopted Children from Non-European Countries: General Development during the First Two Years in the Adoptive Family

    Directory of Open Access Journals (Sweden)

    Monica Dalen

    2012-01-01

    Full Text Available Internationally adopted children are often delayed in their development and demonstrate more behaviour problems than nonadopted children due to adverse preadoption circumstances. This is especially true for children adopted from Eastern European countries. Few studies have focused on children adopted from non-European countries. This paper presents results from an ongoing longitudinal study of 119 internationally adopted children from non-European countries during their first two years in Norway. Several scales measuring different aspects of the children’s development are included in the study: communication and gross motor development, temperamental characteristics, and behaviour problems. The results show that internationally adopted children are delayed in their general development when they first arrive in their adoptive families. After two years the children have made significant progress in development. However, they still lag behind in communication and motor skills compared to non-adopted children. The temperamental characteristics seem very stable from time of adoption until two years after adoption. The children demonstrate a low frequency of behaviour problems. However, the behaviour problems have changed during the two years. At time of adoption they show more nonphysically challenging behaviour while after two years their physically challenging behaviour has increased.

  19. Internationally adopted children from non-European countries: general development during the first two years in the adoptive family.

    Science.gov (United States)

    Dalen, Monica; Theie, Steinar

    2012-01-01

    Internationally adopted children are often delayed in their development and demonstrate more behaviour problems than nonadopted children due to adverse preadoption circumstances. This is especially true for children adopted from Eastern European countries. Few studies have focused on children adopted from non-European countries. This paper presents results from an ongoing longitudinal study of 119 internationally adopted children from non-European countries during their first two years in Norway. Several scales measuring different aspects of the children's development are included in the study: communication and gross motor development, temperamental characteristics, and behaviour problems. The results show that internationally adopted children are delayed in their general development when they first arrive in their adoptive families. After two years the children have made significant progress in development. However, they still lag behind in communication and motor skills compared to non-adopted children. The temperamental characteristics seem very stable from time of adoption until two years after adoption. The children demonstrate a low frequency of behaviour problems. However, the behaviour problems have changed during the two years. At time of adoption they show more nonphysically challenging behaviour while after two years their physically challenging behaviour has increased.

  20. Reliability of Serum Metabolites over a Two-Year Period: A Targeted Metabolomic Approach in Fasting and Non-Fasting Samples from EPIC

    Science.gov (United States)

    Achaintre, David; Sacerdote, Carlotta; Vineis, Paolo; Key, Timothy J.; Onland Moret, N. Charlotte; Scalbert, Augustin; Rinaldi, Sabina; Ferrari, Pietro

    2015-01-01

    Objective Although metabolic profiles have been associated with chronic disease risk, lack of temporal stability of metabolite levels could limit their use in epidemiological investigations. The present study aims to evaluate the reliability over a two-year period of 158 metabolites and compare reliability over time in fasting and non-fasting serum samples. Methods Metabolites were measured with the AbsolueIDQp180 kit (Biocrates, Innsbruck, Austria) by mass spectrometry and included acylcarnitines, amino acids, biogenic amines, hexoses, phosphatidylcholines and sphingomyelins. Measurements were performed on repeat serum samples collected two years apart in 27 fasting men from Turin, Italy, and 39 non-fasting women from Utrecht, The Netherlands, all participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Reproducibility was assessed by estimating intraclass correlation coefficients (ICCs) in multivariable mixed models. Results In fasting samples, a median ICC of 0.70 was observed. ICC values were fasting samples, the median ICC was 0.54. ICC values were fasting as compared to fasting samples, with a statistically significant difference for 19–36% of acylcarnitines, phosphatidylcholines and sphingomyelins. Conclusion A single measurement per individual may be sufficient for the study of 73% and 52% of the metabolites showing ICCs >0.50 in fasting and non-fasting samples, respectively. ICCs were higher in fasting samples that are preferable to non-fasting. PMID:26274920

  1. Urinary incontinence and vaginal squeeze pressure two years post-cesarean delivery in primiparous women with previous gestational diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Angélica Mércia Pascon Barbosa

    2011-01-01

    Full Text Available OBJECTIVE: To assess the prevalence of urinary incontinence and associated vaginal squeeze pressure in primiparous women with and without previous gestational diabetes mellitus two years post-cesarean delivery. METHODS: Primiparous women who delivered by cesarean two years previously were interviewed about the delivery and the occurrence of incontinence. Incontinence was reported by the women and vaginal pressure evaluated by a Perina perineometer. Sixty-three women with gestational diabetes and 98 women without the disease were screened for incontinence and vaginal pressure. Multiple logistic regression models were used to evaluate the independent effects of gestational diabetes. RESULTS: The prevalence of gestational incontinence was higher among women with gestational diabetes during their pregnancies (50.8% vs. 31.6% and two years after a cesarean (44.8% vs. 18.4%. Decreased vaginal pressure was also significantly higher among women with gestational diabetes (53.9% vs. 37.8%. Maternal weight gain and newborn weight were risk factors for decreased vaginal pressure. Maternal age, gestational incontinence and decreased vaginal pressure were risk factors for incontinence two years after a cesarean. In a multivariate logistic model, gestational diabetes was an independent risk factor for gestational incontinence. CONCLUSIONS: The prevalence of incontinence and decreased vaginal pressure two years post-cesarean were elevated among women with gestational diabetes compared to women who were normoglycemic during pregnancy. We confirmed an association between gestational diabetes mellitus and a subsequent decrease of vaginal pressure two years post-cesarean. These results may warrant more comprehensive prospective and translational studies.

  2. Salvage logging effect on soil properties in a fire-affected Mediterranean forest: a two years monitoring research

    Science.gov (United States)

    Mataix-Solera, Jorge; Moltó, Jorge; Arcenegui, Vicky; García-Orenes, Fuensanta; Chrenkovà, Katerina; Torres, Pilar; Jara-Navarro, Ana B.; Díaz, Gisela; Izquierdo, Ezequiel

    2015-04-01

    In the Mediterranean countries, forest fires are common and must be considered as an ecological factor, but changes in land use, especially in the last five decades have provoked a modification in their natural regime. Moreover, post-fire management can have an additional impact on the ecosystem; in some cases, even more severe than the fire. Salvage logging is a traditional management in most fire-affected areas. In some cases, the way of doing it, using heavy machinery, and the vulnerability of soils to erosion and degradation make this management potentially very agresive to soil, and therefore to the ecosystem. Very little research has been done to study how this treatment could affect soil health. In this research we show 2 years of monitoring of some soil properties in an area affected by a forest fire, where some months later this treatment was applied. The study area is located in 'Sierra de Mariola Natural Park' in Alcoi, Alicante (E Spain). A big forest fire (>500 has) occurred in July 2012. The forest is composed mainly of Pinus halepensis trees with an understory of typical Mediterranean shrubs species such as Quercus coccifera, Rosmarinus officinalis, Thymus vulgaris, Brachypodium retusum, etc. Soil is classified as a Typic Xerorthent (Soil Survey Staff, 2014) developed over marls. In February 2013, salvage logging (SL) treatment consisting in a complete extraction of the burned wood using heavy machinery was applied in a part of the affected forest. Plots for monitoring this effect were installed in this area and in a similar nearby area where no treatment was done, and then used as control (C) for comparison. Soil samplings were done immediately after treatment and every 6 months. Some soil properties were analysed, including soil organic matter (SOM) content, basal soil respiration (BSR), microbial biomass carbon (MBC), bulk density (BD), soil water repellency (SWR), aggregate stability (AS), field capacity, nitrogen, etc. After two years of

  3. Infrared Spectroscopy as a Preview of Coming Attractions: Teaching Chemistry with Instrumental Methods at Two-Year Colleges

    Science.gov (United States)

    Brown, David R.; Bushey, Michelle

    2010-01-01

    Two-year colleges (2YCs) provide a significant amount of chemical education to undergraduates in the United States. By design, the charge of the 2YCs is to provide coursework at the lower-division level. Nonetheless, general chemistry courses in 2YCs can be enhanced with content to prepare future chemistry majors for upper-division education. The…

  4. The Impact of Achieve3000 on Elementary Literacy Outcomes: Evidence from a Two-Year Randomized Control Trial

    Science.gov (United States)

    Hill, Darryl V.; Lenard, Matthew A.; Page, Lindsay Coleman

    2016-01-01

    School districts are increasingly adopting technology-based resources in an attempt to improve student achievement. This paper reports the two-year results from randomized control trial of Achieve3000 in the Wake County Public School System (WCPSS) in Raleigh, North Carolina. Achieve3000 is an early literacy program that differentiates non-fiction…

  5. Who is "Daddy" Revisited: The Status of Two-Year-Olds' Over-Extended Words in Use and Comprehension

    Science.gov (United States)

    Thomson, Jean R.; Chapman, Robin S.

    1977-01-01

    Diary observations of two-year-olds' over-extended word use have been interpreted as arising from the word's underlying semantic feature structure. This interpretation was rejected after a study of five children. The need to construct models of early word meaning reflecting certain early language development patterns is discussed. (CHK)

  6. An evaluation of a community-based basic parenting programme: a two-year follow-up.

    Science.gov (United States)

    Roberts, Deborah

    2012-02-01

    Behavioural difficulties in the early years and through primary school age present a challenge to community practitioners; and the long-term costs to society of untreated conduct disorder place a huge financial strain on services, as well as leading to a poor prognosis for the children affected. The aim of this study was to establish the long-term effects for participants attending a 12-week Basic Incredible Years Programme, two years post-completion. Fifty-seven participants were interviewed, representing 63% of the original sample, who parented children aged 1-12 years. Pre- and post-intervention and follow-up measures were the General Health Questionnaire (30) and Eyberg Child Behaviour Checklist. The most common theme reported was that it had helped to change their child's behaviour, and this was demonstrated quantitatively with mean average scores for the Eyberg Child Behaviour Inventory reducing to below clinical cut-off post-group and at two years. This same pattern was seen for participants' mental health, with improvements largely maintained at two years. Of the one-third of the children whose behaviour deteriorated two years after the course, two-thirds of these children had experienced adverse life events or had a secondary diagnosis.

  7. "Etxadi-Gangoiti" Scale: A Proposal to Evaluate the Family Contexts of Two-Year-Old Children

    Science.gov (United States)

    Arranz Freijo, Enrique B.; Olabarrieta Artetxe, Fernando; Manzano Fernández, Ainhoa; Martín Ayala, Juan luís; Galende Pérez, Nuria

    2014-01-01

    This paper makes a proposal for the comprehensive assessment of the family context of children aged two years. It offers an updated resource based on recent research into the assessment of family contexts and their influence on children's psychological development. The proposal explores the following areas: Presence of learning materials;…

  8. Prevalence of urinary incontinence and pelvic floor muscle dysfunction in primiparae two years after cesarean section: cross-sectional study.

    Science.gov (United States)

    Barbosa, Angélica Mércia Pascon; Marini, Gabriela; Piculo, Fernanda; Rudge, Cibele Vieira Cunha; Calderon, Iracema Mattos Paranhos; Rudge, Marilza Vieira Cunha

    2013-01-01

    There is uncertainty in the literature regarding the theory that obstetric events and pelvic floor injuries give rise to lower risk of subsequent urinary incontinence among women delivering via cesarean section than among women delivering vaginally. The objective of this study was to assess the two-year postpartum prevalence of urinary incontinence and pelvic floor muscle dysfunction and the factors responsible for them. Cross-sectional study, conducted in a public university. 220 women who had undergone elective cesarean section or vaginal childbirth two years earlier were selected. Their urinary incontinence symptoms were investigated, and their pelvic floor muscle dysfunction was assessed using digital palpation and a perineometer. The two-year urinary incontinence prevalences following vaginal childbirth and cesarean section were 17% and 18.9%, respectively. The only risk factor for pelvic floor muscle dysfunction was weight gain during pregnancy. Body mass index less than 25 kg/m 2 and normal pelvic floor muscle function protected against urinary incontinence. Gestational urinary incontinence increased the risk of two-year postpartum urinary incontinence. Gestational urinary incontinence was a crucial precursor of postpartum urinary incontinence. Weight gain during pregnancy increased the subsequent risk of pelvic floor muscle dysfunction, and elective cesarean section did not prevent urinary incontinence.

  9. Relationship between Students' Reading Ability and Their Success in Medical Terminology at a Two-Year College

    Science.gov (United States)

    Ryan, Mary Gene

    2011-01-01

    Health sciences faculty members at a two-year college were concerned about the poor pass rates in medical terminology, a gateway course for all students planning to major in health-related fields. Faculty suspected that students coming out of developmental reading might not have adequate reading skills to do well in medical terminology.…

  10. 5 CFR 2641.202 - Two-year restriction on any former employee's representations to United States concerning...

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Two-year restriction on any former employee's representations to United States concerning particular matter for which the employee had official responsibility. 2641.202 Section 2641.202 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT ETHICS POST-EMPLOYMENT CONFLICT OF...

  11. 5 CFR 2641.205 - Two-year restriction on any former very senior employee's representations to former agency or...

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Two-year restriction on any former very senior employee's representations to former agency or certain officials concerning any matter, regardless of prior involvement. 2641.205 Section 2641.205 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT ETHICS POST-EMPLOYMENT CONFLICT...

  12. Toxicologic Laboratory Findings in Cases Reported with Hanging Death: a Two-Year Retrospective Study in Northeast Iran

    Directory of Open Access Journals (Sweden)

    Mohammad Ranjbar

    2013-09-01

    How to cite this article: Ranjbar R, Liaghat AR, Ranjbar A, Mohabbati H. Toxicologic Laboratory Findings in Cases Reported with Hanging Death: a Two-Year Retrospective Study in Northeast Iran. Asia Pac J Med Toxicol 2013;2:92-5.

  13. Three Incomplete Caries Removal Techniques Compared Over Two Years in Primary Molars with Asymptomatic Deep Caries or Reversible Pulpitis.

    Science.gov (United States)

    Chompu-inwai, Papimon; Boonsongsawat, Kamolthip; Sastraruji, Thanapat; Sophasri, Tidarat; Mankaen, Siripun; Nondon, Sutasinee; Tunlek, Sumattaya; Katwong, Supitchaya

    2015-01-01

    To directly compare the survival rates of three incomplete caries removal techniques that differed in the amount of caries removal and the base material used. Ninety-six primary molars with asymptomatic deep caries or reversible pulpitis were randomly assigned to three groups: (1) indirect pulp treatment (IPT); (2) minimal caries removal with both resin-modified glass ionomer base material and luting cement (MCRB/L); and (3) minimal caries removal with only resin-modified glass ionomer luting cement (MCRL). The treatments were followed clinically and radiographically for two years. The two-year survival probabilities in the IPT, MCRB/L, and MCRL groups were 0.90 (95 percent confidence interval [CI] equals 0.73 to 0.97), 0.93 (95 percent CI equals 0.76 to 0.98), and 0.77 (95 percent CI equals 0.58 to 0.89), respectively. There was no significant difference in the two-year survival probabilities of the three studied groups (generalized Wilcoxon P=.07). Following two years, neither the amount of caries removal nor the base material affected the success of incomplete caries removal treatment. However, minimal caries removal with MCRB/L presented the highest survival rate among the tested groups and resulted in no incidence of pulp exposure.

  14. A Two-Year Follow-Up of a Staff Development Program Designed to Change Teacher Behavior

    Science.gov (United States)

    Schaffer, Eugene; Stringfield, Samuel; Devlin-Scherer, Roberta

    2017-01-01

    Two years after participating in a replication of the Stallings Effective Use of Time (EUOT) Program, ten teachers were re-observed and interviewed to determine the extent to which they had maintained the measured changes in their behavior patterns. Subjects were selected for the follow-up from a 27 EUOT teacher sample based on having exhibited…

  15. Prevalence of urinary incontinence and pelvic floor muscle dysfunction in primiparae two years after cesarean section: cross-sectional study

    Directory of Open Access Journals (Sweden)

    Angélica Mércia Pascon Barbosa

    Full Text Available CONTEXT AND OBJECTIVE There is uncertainty in the literature regarding the theory that obstetric events and pelvic floor injuries give rise to lower risk of subsequent urinary incontinence among women delivering via cesarean section than among women delivering vaginally. The objective of this study was to assess the two-year postpartum prevalence of urinary incontinence and pelvic floor muscle dysfunction and the factors responsible for them. DESIGN AND SETTING Cross-sectional study, conducted in a public university. METHODS 220 women who had undergone elective cesarean section or vaginal childbirth two years earlier were selected. Their urinary incontinence symptoms were investigated, and their pelvic floor muscle dysfunction was assessed using digital palpation and a perineometer. RESULTS The two-year urinary incontinence prevalences following vaginal childbirth and cesarean section were 17% and 18.9%, respectively. The only risk factor for pelvic floor muscle dysfunction was weight gain during pregnancy. Body mass index less than 25 kg/m 2 and normal pelvic floor muscle function protected against urinary incontinence. Gestational urinary incontinence increased the risk of two-year postpartum urinary incontinence. CONCLUSION Gestational urinary incontinence was a crucial precursor of postpartum urinary incontinence. Weight gain during pregnancy increased the subsequent risk of pelvic floor muscle dysfunction, and elective cesarean section did not prevent urinary incontinence.

  16. Identifying Effective Design Features of Technology-Infused Inquiry Learning Modules: A Two-Year Study of Students' Inquiry Abilities

    Science.gov (United States)

    Hsu, Ying-Shao; Fang, Su-Chi; Zhang, Wen-Xin; Hsin-Kai, Wu; Wu, Pai-Hsing; Hwang, Fu-Kwun

    2016-01-01

    The two-year study aimed to explore how students' development of different inquiry abilities actually benefited from the design of technology-infused learning modules. Three learning modules on the topics of seasons, environmental issues and air pollution were developed to facilitate students' inquiry abilities: questioning, planning, analyzing,…

  17. Relationship between two year PSA nadir and biochemical recurrence in prostate cancer patients treated with iodine-125 brachytherapy

    Directory of Open Access Journals (Sweden)

    Carlos Antônio da Silva Franca

    2014-04-01

    Full Text Available Objective To evaluate the relationship between two year PSA nadir (PSAn after brachytherapy and biochemical recurrence rates in prostate cancer patients. Materials and Methods In the period from January 1998 to August 2007, 120 patients were treated with iodine-125 brachytherapy alone. The results analysis was based on the definition of biochemical recurrence according to the Phoenix Consensus. Results Biochemical control was observed in 86 patients (71.7%, and biochemical recurrence, in 34 (28.3%. Mean PSAn was 0.53 ng/ml. The mean follow-up was 98 months. The patients were divided into two groups: group 1, with two year PSAn < 0.5 ng/ml after brachytherapy (74 patients; 61.7%, and group 2, with two year PSAn ≥ 0.5 ng/ml after brachytherapy (46 patients; 38.3%. Group 1 presented biochemical recurrence in 15 patients (20.3%, and group 2, in 19 patients (43.2% (p < 0.02. The analysis of biochemical disease-free survival at seven years, stratified by the two groups, showed values of 80% and 64% (p < 0.02, respectively. Conclusion Levels of two year PSAn ≥ 0.5 ng/ml after brachytherapy are strongly correlated with a poor prognosis. This fact may help to identify patients at risk for disease recurrence.

  18. A Strategic Enrollment Management Approach to Studying High School Student Transition to a Two-Year College

    Science.gov (United States)

    Wang, Yan; Ye, Feifei; Pilarzyk, Tom

    2014-01-01

    This study used a strategic enrollment management (SEM) approach to studying high school students' transition to a two-year college and their initial college success. Path analyses suggested two important findings: (a) clear career choices among students, family influence, academic preparedness, and college recruitment efforts predicted earlier…

  19. 78 FR 62322 - Hydropower Regulatory Efficiency Act of 2013; Notice of Rescheduled Two-Year Licensing Process...

    Science.gov (United States)

    2013-10-16

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. AD13-9-000] Hydropower... recommendations on the feasibility of a two-year process for the issuance of a license for hydropower development... Hydropower Regulatory Efficiency Act of 2013. The workshop will be held in the Commission Meeting Room at 888...

  20. The Multigenerational Workforce within Two-Year Public Community Colleges: A Study of Generational Factors Affecting Employee Learning and Interaction

    Science.gov (United States)

    Starks, Florida Elizabeth

    2014-01-01

    The purpose of this quantitative study is to broaden multigenerational workforce research involving factors affecting employee learning and interaction by using a population of Baby Boomer, Generation X, and Millennial faculty and staff age cohorts employed at two-year public community college organizations. Researchers have studied…

  1. Two-Year Institution Part-Time Nurse Faculty Experiences During Role Transition and Identity Development: A Phenomenological Study.

    Science.gov (United States)

    Owens, Rhoda A

    This study explored two-year institution part-time nurse faculty's perceptions of their experiences during their role transitions from nurses in clinical practice to part-time clinical instructors. Part-time nurse faculty enter academia as expert clinicians, but most have little or no training in the pedagogy of effective student learning. A phenomenological study was used to explore the faculty role transition experiences. Findings support the proposition that six participants transitioned from their expert clinician to instructor identities; however, two continue in the process. Critical to this process are relationships with individuals in their environments, past and present experiences, the incentive to learn to be better instructors, and the importance of support and training. A model emerged, Process of Role Transition and Professional Identity Formation for Part-Time Clinical Instructors at Two-Year Institutions, that is potentially useful for administrators in developing individualized orientation and professional development programs.

  2. The five times ten things everyone should have had in their hands before they are ten and two years old.

    Science.gov (United States)

    Hut, R.; Poot, A.

    2017-12-01

    To train the young ones to become people that make stuff, I present the five times ten things we use a lot that everyone should have used before they are ten and two years old. I will bring at least two times ten of these things and show them live to you! And: I will bring a large paper for you to bring home with those five times ten things on it to put in the hands of your kids!

  3. Two-year Outcomes from a Single Surgeon's Learning Curve Experience of Oblique Lateral Interbody Fusion without Intraoperative Neuromonitoring.

    Science.gov (United States)

    Woods, Kamal; Fonseca, Ahtziri; Miller, Larry E

    2017-12-22

    Introduction Oblique lumbar interbody fusion (OLIF) is a newer procedure that avoids the psoas and lumbosacral plexus due to its oblique trajectory into the retroperitoneal space. While early experience with OLIF is reassuring, the longer-term clinical efficacy has not been well established. The purpose of this study was to describe two-year clinical outcomes with OLIF performed by a single surgeon during the learning curve without the aid of the neuromonitoring. Materials and methods Chart review was performed for the consecutive patients who underwent OLIF by a single surgeon. Back pain severity on a visual analog scale (VAS) and Oswestry Disability Index (ODI) were collected preoperatively and postoperatively at six weeks, three months, six months, one year and two years. Results A total of 21 patients (38 levels) were included in this study. The indications for surgery were degenerative disc disease (n=10, 47.6%), spondylolisthesis (n=9, 42.9%) and spinal stenosis (n=6, 28.6%). The median operating room time was 351 minutes (interquartile range (IQR): 279-406 minutes), blood loss was 40 ml (IQR: 30-150 ml), and hospital stay was 2.0 days (IQR: 1.0-3.5 days). The complication rate was 9.5%, both venous injuries. There were no other perioperative complications. Back pain severity decreased by 70%, on average, over two years (p safe and clinically efficacious for up to two years. The complication rate in this cohort is similar to other published OLIF series and appears acceptable when compared to the lateral lumbar interbody fusion (LLIF) and the anterior lumbar interbody fusion (ALIF). No motor or sensory deficits were observed in this study, supporting the premise that the neuromonitoring is unnecessary in OLIF.

  4. Maternal Factors as Moderators or Mediators of PTSD Symptoms in Very Young Children: A Two-Year Prospective Study

    OpenAIRE

    Scheeringa, Michael S.; Myers, Leann; Putnam, Frank W.; Zeanah, Charles H.

    2015-01-01

    Research has suggested that parenting behaviors and other parental factors impact the long-term outcome of children’s posttraumatic stress disorder (PTSD) symptoms. In a sample of 62 children between the ages of one and six who experienced life-threatening traumas, PTSD was measured prospectively two years apart. Seven maternal factors were measured in a multi-method, multi-informant design. Both moderation and mediation models, with different theoretical and mechanism implications, were test...

  5. Change in job stress and job satisfaction over a two-year interval using the Brief Job Stress Questionnaire.

    Science.gov (United States)

    Kawada, Tomoyuki; Otsuka, Toshiaki

    2014-01-01

    The relationship between job stress and job satisfaction by the follow-up study should be more evaluated for workers' health support. Job stress is strongly affected by the content of the job and the personality of a worker. This study was focused on determining the changes of the job stress and job satisfaction levels over a two-year interval, using the Brief Job Stress Questionnaire (BJSQ). This self-administered questionnaire was distributed to the same 310 employees of a Japanese industrial company in 2009 and 2011. Sixty-one employees were lost from 371 responders in 2009. Data of 16 items from 57 items graded on a four-point Likert-type scale to measure the job stressors, psycho-physical complaints and support for workers, job overload (six items), job control (three items), support (six items) and job satisfaction score (one item) were selected for the analysis. The age-adjusted partial correlation coefficients for job overload, job control and support were 0.684 (pjob overload, job control and support were 0.681 (0.616-0.736), 0.473 (0.382-0.555), and 0.623 (0.549-0.687), respectively. There were no significant differences in the mean score for job overload, job control or support, although significant decline in the job satisfaction level was apparent at the end of the two-year period (pjob satisfaction in 2009 and in 2011 for subjects with keeping low job strain. No significant changes in the scores on the three elements of job stress were observed over the two-year study period, and the job satisfaction level deteriorated significantly during this period. There was a decline in the job satisfaction in the two-year period, although subjects did not suffer from job stress at the same period.

  6. GATEWAY Demonstrations: LED System Performance in a Trial Installation--Two Years Later, Yuma Border Patrol, Yuma, Arizona

    Energy Technology Data Exchange (ETDEWEB)

    Wilkerson, Andrea M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Sullivan, Gregory P. [Efficiency Solutions, Inc., Richland, WA (United States); Davis, Robert G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-04-01

    Along the Yuma Sector Border Patrol Area in Yuma, Arizona, the GATEWAY program conducted a trial demonstration in which the incumbent quartz metal halide area lighting was replaced with LED at three pole locations at the Yuma Sector Border Patrol Area in Yuma, Arizona. The retrofit was documented to better understand LED technology performance in high-temperature environments. This report follows the GATEWAY Yuma Phase 1.1 Report and reflects LED system results documented two years after the demonstration began.

  7. Course, risk factors, and prognostic factors in elderly primary care patients with mild depression: a two-year observational study.

    Science.gov (United States)

    Magnil, Maria; Janmarker, Lena; Gunnarsson, Ronny; Björkelund, Cecilia

    2013-03-01

    The aim of this study was to observe course, risk factors, and prognostic factors in a primary care cohort aged > 60 with mild to moderate depression during two-year follow-up. Observational study. Primary care. During an 11-month period all (n = 302) consecutive patients aged 60 and above attending a primary care centre in Gothenburg, Sweden were screened by a nurse for depressive symptoms with the Primary Care Evaluation of Mental Disorders, Patient Questionnaire (PRIME-MD PQ) and the Montgomery-Åsberg Depression Rating Scale, self-rated version (MADRS-S) and by a GP with a patient-centred consultation model. In the second step, the GPs diagnosed depression in screen-positives by use of the PRIME-MD Clinical Evaluation Guide (PRIME-MD CEG). All patients with mild to moderate depression were followed up for two years to assess course with several MADRS-S score assessments. Main outcome measures. Risk factors, prognostic factors, and symptoms at baseline and after two years were tested with logistic regression, using the DSM-IV and MADRS-S (cut-off > 13) respectively. Course patterns were observed and described. A total of 54 patients were diagnosed with depression. Follow-up revealed declining median MADRS-S scores and three course patterns: remitting, stable, and fluctuating. History of depression, significant life events, lacking leisure activities, and use of sedatives were risk factors for depression, all previously known. An important finding was that lacking leisure activities also increased the risk of depressive symptoms after two years (odds ratio 12, confidence interval 1.1-136). It is desirable to identify elderly individuals with less severe depression. Three course patterns were observed; this finding requires further study of the clinical characteristics related to the different patterns. Awareness of risk factors may facilitate identification of those at highest risk of poor prognosis.

  8. Associations between Reoperations and Psychological Factors after Contralateral Risk-Reducing Mastectomy: A Two-Year Follow-Up Study

    Directory of Open Access Journals (Sweden)

    Dmytro Unukovych

    2016-01-01

    Full Text Available Introduction. The aim of the study was to investigate associations between reoperations after contralateral risk-reducing mastectomies (CRRM and emotional problems, body image, sexuality, and health related quality of life (HRQoL in women with breast cancer and hereditary high risk. Patients and Methods. Patients scheduled for CRRM with breast reconstruction between 1998 and 2010 completed questionnaires, comprised of SF-36, the Hospital Anxiety and Depression Scale, the Body Image Scale, and the Sexual Activity Questionnaire, preoperatively and two years after CRRM. Data on reoperations was collected from medical charts. Results. A total of 80 women participated, with a response rate of 61 (76% preoperatively and 57 (71% at the two-year follow-up. At the two-year assessment, 44 (55% patients had undergone ≥1 reoperation (reoperation group, whereas 36 (45% had not (no reoperation group. No statistically significant differences between the groups were found for HRQoL, sexuality, anxiety, or depression. A higher proportion of patients in the “reoperation group” reported being dissatisfied with their bodies (81% versus 48%, p=0.01. Conclusion. The results suggest associations between reoperation following CRRM with breast reconstruction and body image problems. Special attention should be paid to body image problems among women who are subject to reoperations after CRRM.

  9. Health status, resource consumption, and costs of dysthymia. A multi-center two-year longitudinal study.

    Science.gov (United States)

    Barbui, Corrado; Motterlini, Nicola; Garattini, Livio

    2006-02-01

    In this study we estimated the health status, resource consumption and costs of a large cohort of patients with early and late-onset dysthymia. The DYSCO (DYSthymia COsts) project is a multi-center observational study which prospectively followed for two years a randomly chosen sample of patients with dysthymia in the Italian primary health care system. A total of 501 patients were followed for two years; 81% had early-onset dysthymic disorder. During the study, improvement was seen in most domains of the 36-Item Short Form Health Survey (SF-36) questionnaire. Comparison of the SF-36 scores for the two groups showed that only the physical health index significantly differed during the two years. The use of outpatient consultations, laboratory tests and diagnostic procedures was similar in the two groups, but patients with early-onset dysthymia were admitted significantly more than late-onset cases. Hospital admissions were almost entirely responsible for the higher total cost per patient per year of early-onset dysthymia. A first limitation of this study is that general practitioners were selected on the basis of their willingness to participate, not at random; secondly, no information was collected on concomitant psychiatric comorbidities. The present study provides the first prospective, long-term data on service use and costs in patients with dysthymia. Differently from patients with early-onset dysthymia, patients with late-onset dysthymia were admitted less and cost less.

  10. Haemodialysis in an emerging centre in a developing country: a two year review and predictors of mortality

    Directory of Open Access Journals (Sweden)

    Ikpeme Enobong E

    2011-10-01

    Full Text Available Abstract Background Haemodialysis is the most common form of renal replacement therapy in Nigeria. The high cost of haemodialysis has made optimal therapy of end-stage renal disease difficult in Nigeria. This paper is a review of data collected over two years of provision of dialysis services in a new tertiary hospital in Southern Nigeria. Methods This retrospective analysis is done on data obtained from the patient case files and dialysis records in the first two years of provision of dialysis services in our centre. A gender comparison of the patients' baseline sociodemographic, clinical and biochemical was performed and a logistic regression model used to assess the predictors of mortality. Results A total of 98 patients had 471 sessions in the two years under review. Males and females had similar characteristics at baseline except for a higher median serum urea in the males. The commonest causes of end-stage renal disease were chronic glomerulonephritis (34.5%, hypertension (32.1% and diabetes mellitus (17.9%. The main predictor of mortality was under treatment with haemodialysis due to inability to pay for more than a few dialysis sessions. Conclusions This study has highlighted the unchanging demographics of our advanced kidney failure patients. Efforts should be aimed at subsidizing the cost of dialysis for our teeming population of dialysis dependent chronic kidney disease patients.

  11. Two-Year Stability and Change in Access to and Reasons for Lacking a Usual Source of Care Among Working-Age US Adults.

    Science.gov (United States)

    Stransky, Michelle L

    The objective of this study was to investigate usual source of care (USC) over time. A nationally representative sample of working-age adults in the Medical Expenditure Panel Survey (Panels 16 [2011-2012] and 17 [2012-2013]) was divided into 3 groups based on USC questions asked during 2 waves: (1) those having a USC during both waves (always USC), (2) those not having a USC during either wave (never USC), and (3) those who gained or lost a USC between the 2 waves (changed USC). The study examined the sociodemographic and health characteristics associated with these groups and the main reasons for not having a USC among those who never had a USC and those who changed their USC. Of the 10 792 adults in the analysis, a longitudinally weighted 18.8% reported that their USC changed during the period. Among adults in the changed USC group, those with private (odds ratio [OR] = 2.0, P = .001) or public (OR = 2.2, P = .001) health insurance and 1 (OR = 1.7, P = .04) or ≥2 (OR = 3.1, P = .02) chronic health conditions were more likely to transition to having a USC from not having a USC, compared with those who had no insurance and no chronic conditions. Compared with those in the changed USC group, those in the never USC group were more likely to report preferring not to have a USC (57.9% vs 80.1%, P USC and increase the number of adults with ongoing, consistent USC.

  12. Stability of large-area molecular junctions

    NARCIS (Netherlands)

    Akkerman, Hylke B.; Kronemeijer, Auke J.; Harkema, Jan; van Hal, Paul A.; Smits, Edsger C. P.; de Leeuw, Dago M.; Blom, Paul W. M.

    The stability of molecular junctions is crucial for any application of molecular electronics. Degradation of molecular junctions when exposed to ambient conditions is regularly observed. In this report the stability of large-area molecular junctions under ambient conditions for more than two years

  13. Impact of emissions of Pridneprovsk TPP in Dnipropetrovsk on the anatomical indices of stem of two-year whip of the Tilia genus representatives

    Directory of Open Access Journals (Sweden)

    Z. V. Gritzay

    2015-09-01

    Full Text Available The paper presents discussion of the results of studying the impact of environmental contamination because of emissions of Pridneprovsk TPP in Dnipropetrovsk city on the anatomical indices of stem of two-year whip of the Tilia genus representatives. Objects of study were T. platyphyllos Scop., T. europaea L. and T. cordata Mill. Material was collected in September 2015 on two sampling areas: experimental plot – tree plantations adjacent to Pridneprovsk TPP which emissions mainly comprise the pollutants such as sulfur dioxide, nitrogen oxides, particulate matter, with the share in total volume of emissions of the Plant being 67.3%, 18.7%, 13.3%, respectively; control plot (conditionally clean – territory of the Botanical garden of Oles Honchar Dnipropetrovsk National University. For research, two-year whips located in the apical portion of branches of the same order of branching were taken. Sections were made at the medium cross-line of the stem, and stained with the alcoholic solution of phloroglucinol. 30 sections for each species were measured on each sampling area. In the objects under study on technogenically contaminated area the changes in dimensions of histological elements of the stem were found and the nature of such changes had specific differences. T. platyphyllos and T. europaea under action of toxic emissions of TPP demonstrated the increase of total size of primary cortex of stem and width of its individual components (plug, collenchyma, cortex parenchyma, maintenance of stable dimensions of the bark and its histological elements (hard and soft bast, and in T. europaea the wood radius as well, which we considered as the indicators of relative stability of these species in technogenic environment. In T. cordata in the TPP emission zone we revealed the increase in the width of plug, cortex parenchyma, and total radius of primary cortex, which could provide certain tolerance of plants of this species in the adverse conditions of

  14. Early-life risk factors identified for owner-reported feline overweight and obesity at around two years of age.

    Science.gov (United States)

    Rowe, E C; Browne, W J; Casey, R A; Gruffydd-Jones, T J; Murray, J K

    2017-08-01

    Obesity is considered the second most common health problem in pet cats in developed countries. This study used prospective data from a longitudinal study of pet cats ('C.L.A.W.S.', www.bristol.ac.uk/vetscience/claws) to identify early-life risk factors for feline overweight/obesity occurring at around two years of age. Data were collected via five owner-completed questionnaires (for cats aged two-six months, six months, 12 months, 18 months and two years respectively) completed between May 2011 and April 2015. Owner-reported body condition scores (BCS) of cats at age two years, assessed using images from the 9-point BCS system (Laflamme, 1997), were categorised into a dichotomous variable: overweight/obese (BCS 6-9) and not overweight (BCS 1-5) and used as the dependent variable. Of the 375 cats with owner-reported BCS, 25.3% were overweight or obese at two years of age. Multivariable logistic regression models were built using stepwise forward-selection. To account for potential hierarchical clustering due to multi-cat households two-level random intercept models were considered but clustering had no impact on the analysis. Models were compared using Wald tests. Six factors were significantly associated with overweight/obesity at two years of age: being overweight or obese at one year of age (OR=10.6, 95%CI 4.4-25.3); owner belief that BCS 7 was the ideal weight (OR=33.2, 95%CI 8.5-129.4), or that BCS represented overweight cats but they would not be concerned if their cat were classified in this category (OR=2.7, 95%CI 1.2-6.2), at questionnaire five completion; vets advising owners that the cat should lose weight, or making no comment on their weight, between one and two years of age (OR=12.1, 95%CI 3.2-44.9 and OR=3.9, 95%CI 1.5-10.3 respectively); owners giving their cat treats when they "felt happy" with them at 18 months of age (OR=2.7, 95%CI 1.0 - 7.3); feeding ≥250g wet food daily between two and six months of age (OR=2.7, 95%CI 1.2-5.9), and feeding

  15. Percutaneous laser disc decompression versus conventional microdiscectomy for patients with sciatica: Two-year results of a randomised controlled trial.

    Science.gov (United States)

    Brouwer, Patrick A; Brand, Ronald; van den Akker-van Marle, M Elske; Jacobs, Wilco Ch; Schenk, Barry; van den Berg-Huijsmans, Annette A; Koes, Bart W; Arts, Mark A; van Buchem, M A; Peul, Wilco C

    2017-06-01

    Background Percutaneous laser disc decompression is a minimally invasive treatment, for lumbar disc herniation and might serve as an alternative to surgical management of sciatica. In a randomised trial with two-year follow-up we assessed the clinical effectiveness of percutaneous laser disc decompression compared to conventional surgery. Materials and methods This multicentre randomised prospective trial with a non-inferiority design, was carried out according to an intent-to-treat protocol with full institutional review board approval. One hundred and fifteen eligible surgical candidates, with sciatica from a disc herniation smaller than one-third of the spinal canal, were randomly allocated to percutaneous laser disc decompression ( n = 55) or conventional surgery ( n = 57). The main outcome measures for this trial were the Roland-Morris Disability Questionnaire for sciatica, visual analogue scores for back and leg pain and the patient's report of perceived recovery. Results The primary outcome measures showed no significant difference or clinically relevant difference between the two groups at two-year follow-up. The re-operation rate was 21% in the surgery group, which is relatively high, and with an even higher 52% in the percutaneous laser disc decompression group. Conclusion At two-year follow-up, a strategy of percutaneous laser disc decompression, followed by surgery if needed, resulted in non-inferior outcomes compared to a strategy of microdiscectomy. Although the rate of reoperation in the percutaneous laser disc decompression group was higher than expected, surgery could be avoided in 48% of those patients that were originally candidates for surgery. Percutaneous laser disc decompression, as a non-surgical method, could have a place in the treatment arsenal of sciatica caused by contained herniated discs.

  16. Cognitive reserve as a predictor of two year neuropsychological performance in early onset first-episode schizophrenia.

    Science.gov (United States)

    de la Serna, Elena; Andrés-Perpiñá, Susana; Puig, Olga; Baeza, Inmaculada; Bombin, Igor; Bartrés-Faz, David; Arango, Celso; Gonzalez-Pinto, Ana; Parellada, Mara; Mayoral, María; Graell, Montserrat; Otero, Soraya; Guardia, Joan; Castro-Fornieles, Josefina

    2013-01-01

    The concept of cognitive reserve (CR) has been defined as individual differences in the efficient utilization of brain networks which allow some people to cope better than others with brain pathology. CR has been developed mainly in the field of aging and dementia after it was observed that there appears to be no direct relationship between the degree of brain pathology and the severity of clinical manifestations of this damage. The present study applies the concept of CR to a sample of children and adolescents with a first episode of schizophrenia, aiming to assess the possible influence of CR on neuropsychological performance after two year follow-up, controlling for the influence of clinical psychopathology. 35 patients meeting DSM-IV criteria for schizophrenia or schizoaffective disorder (SSD) and 98 healthy controls (HC) matched for age and gender were included. CR was assessed at baseline, taking into account premorbid IQ, educational-occupational level and leisure activities. Clinical and neuropsychological assessments were completed by all patients at two year follow-up. The CR proxy was able to predict working memory and attention at two year follow-up. Verbal memory and cognitive flexibility were not predicted by any of the variables included in the regression model. The SSD group obtained lower scores than HC on CR. CR measures correctly classified 79.8% of the sample as being SSD or HC. Lower scores on CR were observed in SSD than in HC and the CR measure correctly classified a high percentage of the sample into the two groups. CR may predict SSD performance on working memory and attention tasks. Copyright © 2012 Elsevier B.V. All rights reserved.

  17. Nurses’ research utilization two years after graduation—a national survey of associated individual, organizational, and educational factors

    Science.gov (United States)

    2012-01-01

    Background Nurses’ research utilization (RU) as part of evidence-based practice is strongly emphasized in today’s nursing education and clinical practice. The primary aim of RU is to provide high-quality nursing care to patients. Data on newly graduated nurses’ RU are scarce, but a predominance of low use has been reported in recent studies. Factors associated with nurses’ RU have previously been identified among individual and organizational/contextual factors, but there is a lack of knowledge about how these factors, including educational ones, interact with each other and with RU, particularly in nurses during the first years after graduation. The purpose of this study was therefore to identify factors that predict the probability for low RU among registered nurses two years after graduation. Methods Data were collected as part of the LANE study (Longitudinal Analysis of Nursing Education), a Swedish national survey of nursing students and registered nurses. Data on nurses’ instrumental, conceptual, and persuasive RU were collected two years after graduation (2007, n = 845), together with data on work contextual factors. Data on individual and educational factors were collected in the first year (2002) and last term of education (2004). Guided by an analytic schedule, bivariate analyses, followed by logistic regression modeling, were applied. Results Of the variables associated with RU in the bivariate analyses, six were found to be significantly related to low RU in the final logistic regression model: work in the psychiatric setting, role ambiguity, sufficient staffing, low work challenge, being male, and low student activity. Conclusions A number of factors associated with nurses’ low extent of RU two years postgraduation were found, most of them potentially modifiable. These findings illustrate the multitude of factors related to low RU extent and take their interrelationships into account. This knowledge might serve as useful input in

  18. A virtual water maze revisited: Two-year changes in navigation performance and their neural correlates in healthy adults.

    Science.gov (United States)

    Daugherty, Ana M; Raz, Naftali

    2017-02-01

    Age-related declines in spatial navigation are associated with deficits in procedural and episodic memory and deterioration of their neural substrates. For the lack of longitudinal evidence, the pace and magnitude of these declines and their neural mediators remain unclear. Here we examined virtual navigation in healthy adults (N=213, age 18-77 years) tested twice, two years apart, with complementary indices of navigation performance (path length and complexity) measured over six learning trials at each occasion. Slopes of skill acquisition curves and longitudinal change therein were estimated in structural equation modeling, together with change in regional brain volumes and iron content (R2* relaxometry). Although performance on the first trial did not differ between occasions separated by two years, the slope of path length improvement over trials was shallower and end-of-session performance worse at follow-up. Advanced age, higher pulse pressure, smaller cerebellar and caudate volumes, and greater caudate iron content were associated with longer search paths, i.e. poorer navigation performance. In contrast, path complexity diminished faster over trials at follow-up, albeit less so in older adults. Improvement in path complexity after two years was predicted by lower baseline hippocampal iron content and larger parahippocampal volume. Thus, navigation path length behaves as an index of perceptual-motor skill that is vulnerable to age-related decline, whereas path complexity may reflect cognitive mapping in episodic memory that improves with repeated testing, although not enough to overcome age-related deficits. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Psychometric properties and convergent and predictive validity of an executive function test battery for two-year-olds

    Directory of Open Access Journals (Sweden)

    Hanna eMulder

    2014-07-01

    Full Text Available Executive function (EF is an important predictor of numerous developmental outcomes, such as academic achievement and behavioral adjustment. Although a plethora of measurement instruments exists to assess executive function in children, only few of these are suitable for toddlers, and even fewer have undergone psychometric evaluation. The present study evaluates the psychometric properties and validity of an assessment battery for measuring EF in two-year-olds. A sample of 2437 children were administered the assessment battery at a mean age of 2;4 years (SD = 0;3 years in a large-scale field study. Measures of both hot EF (snack and gift delay tasks and cool EF (six boxes, memory for location, and visual search task were included. Confirmatory Factor Analyses showed that a two-factor hot and cool EF model fitted the data better than a one-factor model. Measurement invariance was supported across groups differing in age, gender, socioeconomic status (SES, home language, and test setting. Criterion and convergent validity were evaluated by examining relationships between EF and age, gender, SES, home language, and parent and teacher reports of children’s attention and inhibitory control. Predictive validity of the test battery was investigated by regressing children’s pre-academic skills and behavioral problems at age three on the latent hot and cool EF factors at age two years. The test battery showed satisfactory psychometric quality and criterion, convergent, and predictive validity. Whereas cool EF predicted both pre-academic skills and behavior problems one year later, hot EF predicted behavior problems only. These results show that EF can be assessed with psychometrically sound instruments in children as young as two years, and that EF tasks can be reliably applied in large scale field research. The current instruments offer new opportunities for investigating EF in early childhood, and for evaluating interventions targeted at improving

  20. Examining Perceived Stigma of Children with Newly-Diagnosed Epilepsy and Their Caregivers Over a Two Year Period

    OpenAIRE

    Rood, Jennifer E.; Schultz, Janet R.; Rausch, Joseph R.; Modi, Avani C.

    2014-01-01

    The purpose of this study was to examine: 1) the course of perceived epilepsy-related stigma among children newly-diagnosed with epilepsy (n=39) and their caregivers (n=97) over a two year period, 2) the influence of seizure absence/presence on children and caregivers’ perception of epilepsy-related stigma, and 3) congruence of child and caregiver perception of child epilepsy-related stigma. Participants completed a measure of perceived epilepsy-related stigma at three time points, and seizur...

  1. Two years of tamoxifen or no adjuvant systemic therapy for patients with high-risk breast cancer

    DEFF Research Database (Denmark)

    Jensen, Maj-Britt; Krarup, Jens Fabricius; Palshof, Torben

    2018-01-01

    randomly assigned to two years of daily placebo or tamoxifen. Survival statistics was collected from the Danish Civil Registration System. RESULTS: The five-year invasive breast cancer recurrence (BCR) rate was 43.2% in the placebo arm and 31.9% in the tamoxifen arm. Compared with the placebo arm...... the hazard ratio for a BCR event was 0.73 in the tamoxifen arm (p = .07). With an estimated median follow-up on overall survival of 40.9 years, 154 and 145 patients had died in the placebo and tamoxifen arm, respectively. After adjustment for baseline characteristics a significant reduction in mortality...

  2. Health related quality of life of mothers and fathers two years after the birth of the first child

    OpenAIRE

    Richter, Rolf

    2010-01-01

    The birth of the first child brings with it considerable changes in the lives of the parents, and the transfer to parenthood is felt to be very demanding in particular by many mothers. There is a marked decrease in the mean satisfaction with the partnership. A stress-resources model is used to analyse which factors influence partnership satisfaction and the health-related quality of life of parents in the first two years of the life of their first child, drawing on data from a controlled inte...

  3. Two-year microbial adaptation during hydrogen-mediated biogas upgrading process in a serial reactor configuration

    DEFF Research Database (Denmark)

    Treu, Laura; Kougias, Panagiotis; de Diego-Díaz, B.

    2018-01-01

    Microbial dynamics in an upgrading biogas reactor system undergoing a more than two years-period at stable operating conditions were explored. The carbon dioxide generated during biomass degradation in the first reactor of the system was converted to methane into the secondary reactor by addition...... of external hydrogen. Considering the overall efficiency, the long-term operation period resulted in an improved biogas upgrading performance (99% methane content). However, a remarkable accumulation of acetate was revealed, indicating the enhancement of homoacetogenic activity. For this reason, a shift...

  4. A Two-Year Multidisciplinary Training Program for the Frontline Workforce in Community Treatment of Severe Mental Illness.

    Science.gov (United States)

    Ruud, Torleif; Flage, Karin Blix; Kolbjørnsrud, Ole-Bjørn; Haugen, Gunnar Brox; Sørlie, Tore

    2016-01-01

    Since 1999, a national two-year multidisciplinary onsite training program has been in operation in Norway. The program trains frontline workforce personnel who provide community treatment to people with severe mental illness. A national network of mental health workers, consumers, caregivers, and others providing or supporting psychosocial treatment and rehabilitation for people with severe mental illness has organized local onsite part-time training programs in collaboration with community mental health centers (CMHCs), municipalities, and primary care providers. CMHC and primary care staff are trained together to increase collaboration. Nationwide dissemination has continued, with new local programs established every year. Evaluations have shown that the program is successful.

  5. [Experience feed back committee in radiotherapy (CREx): a compulsory tool for security management evaluation at two years].

    Science.gov (United States)

    Lartigau, E; Coche-Dequeant, B; Dumortier, V; Giscard, S; Lacornerie, T; Lasue, A; Cheval, V; Martel, V; Malfait, B; Fuchs, A; Pestel, M; Damman, M; Forrest, M

    2008-11-01

    After working on treatment organisation in radiotherapy (bonne pratiques organisationnelles en radiothérapie - action pilote MEAH 2003), the development of a security policy has become crucial. With the help of Air France Consulting and the MEAH, three cancer centers in Angers, Lille and Villejuif worked together on the implantation of experience feed back committees (CREx) dedicated to the registration, analysis and correction of precursor events. After two years, we report the centre Oscar-Lambret experience in Lille and try to get the recommendations for generalisation of the process. This seems now to be compulsory for security management in oncology.

  6. Two years experience with a computer-assisted monitoring and recording system used in gynecological afterloading therapy

    International Nuclear Information System (INIS)

    Kaulich, T.W.; Boedi, R.; Nuesslin, F.; Hirnle, P.

    1990-01-01

    A computer program running on a simple desk-calculator has been developed for monitoring and recording gynecological high-dose afterloading therapy. For treatment monitoring the multiple-probe AM6-system (PTW-Freiburg) is used which allows for dose measurements in the urinary bladder and the rectum. The probe signals are processed on line in order to indicate the actual dose at the measuring points. After completing the irradiation the treatment is documented. Performing fractionated treatment the measuring data are stored in the computer memory for calculating total accumulated dose. The above-described monitoring- and protocolling system has proven its usefulness during two years of clinical work. (orig.) [de

  7. First experiences with application of gadolinium-DTPA in infants and small children under two years of age

    International Nuclear Information System (INIS)

    Maas, R.; Lausch, N.; Buecheler, E.; Grzyska, U.

    1991-01-01

    The use of Gadolinium-DTPA as a paramagnetic contrast agent in MRI with adults and juveniles concerning brain and spinal cord pathology is well proven since years. In the FRG it is only introduced for children over two years of age. Therefore this report deales with the experience in four infants and small children under the age of two. They all were suffering from neurological tumors and got additional diagnostic information in three cases. Clinical side-effects like urticaria, vomiting or convulsions had not been observed nor had pathologic changes of the biochemical parameters been noticed. (orig./GDG) [de

  8. Cable Stability

    Energy Technology Data Exchange (ETDEWEB)

    Bottura, L [European Organization for Nuclear Research, Geneva (Switzerland)

    2014-07-01

    Superconductor stability is at the core of the design of any successful cable and magnet application. This chapter reviews the initial understanding of the stability mechanism, and reviews matters of importance for stability such as the nature and magnitude of the perturbation spectrum and the cooling mechanisms. Various stability strategies are studied, providing criteria that depend on the desired design and operating conditions.

  9. Examining Perceived Stigma of Children with Newly-Diagnosed Epilepsy and Their Caregivers Over a Two Year Period

    Science.gov (United States)

    Rood, Jennifer E.; Schultz, Janet R.; Rausch, Joseph R.; Modi, Avani C.

    2014-01-01

    The purpose of this study was to examine: 1) the course of perceived epilepsy-related stigma among children newly-diagnosed with epilepsy (n=39) and their caregivers (n=97) over a two year period, 2) the influence of seizure absence/presence on children and caregivers’ perception of epilepsy-related stigma, and 3) congruence of child and caregiver perception of child epilepsy-related stigma. Participants completed a measure of perceived epilepsy-related stigma at three time points, and seizure status was collected at the final time point. Results indicated both caregivers (t1,76 = − 2.57 pstigma from diagnosis to two years post-diagnosis. No significant differences were found in caregiver and child report of perceived stigma for children experiencing seizures as compared to children who have been seizure-free for the past year. Results revealed poor caregiver-child agreement of perceived epilepsy-related stigma at all three time points. These data suggest that while children with epilepsy initially perceive epilepsy-related stigma at diagnosis, their perception of stigma decreases over time. Having a better understanding of the course of epilepsy-related stigma provides clinicians with information regarding critical times to support families with stigma reduction interventions. PMID:25173098

  10. Examining perceived stigma of children with newly-diagnosed epilepsy and their caregivers over a two-year period.

    Science.gov (United States)

    Rood, Jennifer E; Schultz, Janet R; Rausch, Joseph R; Modi, Avani C

    2014-10-01

    The purpose of this study was to examine the following: 1) the course of perceived epilepsy-related stigma among children newly diagnosed with epilepsy (n=39) and their caregivers (n=97) over a two-year period, 2) the influence of seizure absence/presence on children and caregivers' perception of epilepsy-related stigma, and 3) the congruence of child and caregiver perception of child epilepsy-related stigma. Participants completed a measure of perceived epilepsy-related stigma at three time points, and seizure status was collected at the final time point. Results indicated that both caregivers (t(1,76)=-2.57, pstigma from diagnosis to two years postdiagnosis. No significant differences were found in caregiver and child reports of perceived stigma for children experiencing seizures compared with children who have been seizure-free for the past year. Results revealed poor caregiver-child agreement of perceived epilepsy-related stigma at all three time points. These data suggest that while children with epilepsy initially perceive epilepsy-related stigma at diagnosis, their perception of stigma decreases over time. Having a better understanding of the course of epilepsy-related stigma provides clinicians with information regarding critical times to support families with stigma reduction interventions. Copyright © 2014 Elsevier Inc. All rights reserved.

  11. Animation-Based Teaching of Semiconductor Devices: Long-Term Improvement in Students’ Achievements in a Two-Year College

    Directory of Open Access Journals (Sweden)

    Aharon Gero

    2015-02-01

    Full Text Available The structure and operating principle of semiconductor devices are a central topic in teaching electronics, both in universities and in two-year colleges. Teachers teaching this subject normally run into substantial difficulties stemming from the fact that a major part of the concepts and processes that are relevant to understanding these devices are abstract. In light of the advantages of multimedia in illustrating dynamic processes, the chapter covering the field effect transistor (FET has recently been taught through animation at a two-year college in Israel. The study presented here has examined, through quantitative tools, whether animation-based teaching of the FET had any effect on students’ achievements in the subject of basic electronic devices. Forty electronics students have participated in the study. Its findings indicate that in the short and long term alike, the achievements of students who studied the transistor through animation were significantly higher than those of their peers who studied it through a traditional method. Additionally, the effect size was very large.

  12. Accident of the Fukushima-Daiichi nuclear power station. Situation two years after the event - IRSN file

    International Nuclear Information System (INIS)

    2013-03-01

    Two years after the Fukushima accident, this report proposes a review of the situation in Japan, and of the European and international actions aimed at preventing the occurrence of another nuclear accident and its radiological consequences. It is based on information available at the end of January or February 2013. After a recall of the situation in Japan and Europe in 2011 (recall of the accident, of the different simulation, calculation and information actions undertaken by the IRSN, launching of a program of additional safety assessments and of European stress tests), the report addresses the situation in Japan two years after the accident: evolution of the nuclear risk management governance, status of the Fukushima-Daiichi power station, health and environmental impact and management of the post-accidental phase, actions undertaken by the IRSN (dose assessment, cooperation in the field of severe accidents, participation to the Fukushima Dialogue). The next part details the contribution of the IRSN to the strengthening of safety and radiation protection at the international level (in relationship with international organizations: IAEA, UNSCEAR and WHO). Additional technical information is provided in appendix, as well as a report on the environmental impact of the accident, and a report on the post-accidental management of the accident

  13. NEW TWO-YEAR RESTRICTION APPLICABLE TO VEHICLES REGISTERED IN THE FRENCH'431 K' AND '431 CD' SERIES

    CERN Multimedia

    Relations with the Host States Service

    2002-01-01

    The French Ministry of Foreign Affairs has recently informed CERN that, with effect from 1st January 2002, owners of vehicles registered in the '431 K' and '431 CD' special series will not be able to change them for other vehicles in these series until two years have elapsed. The Ministry has also reminded us that members of the personnel with diplomatic status who are neither French nor permanent residents are entitled to register one vehicle in the '431 CD' series if they are single and two if they are married. However, irrespective of their marital status, members of the personnel holding an FI or AT carte spéciale, may register only one vehicle in the '431 K' series. CERN has requested the Ministry to clarify certain issues relating to the above and to arrange a transition period for the two-year restriction. Further information on this subject will be published shortly. Relations with the Host States Service http://www.cern.ch/relations/ Tel. 72848

  14. Trace element mobility in a contaminated soil two years after field-amendment with a greenwaste compost mulch

    Energy Technology Data Exchange (ETDEWEB)

    Clemente, Rafael, E-mail: rclemente@cebas.csic.e [Faculty of Sciences, Liverpool John Moores University, Liverpool L3 3AF (United Kingdom); Hartley, William [Faculty of Sciences, Liverpool John Moores University, Liverpool L3 3AF (United Kingdom); Riby, Philip [School of Pharmacy and Chemistry, Liverpool John Moores University, Liverpool L3 3AF (United Kingdom); Dickinson, Nicholas M.; Lepp, Nicholas W. [Faculty of Sciences, Liverpool John Moores University, Liverpool L3 3AF (United Kingdom)

    2010-05-15

    Application of greenwaste compost to brownfield land is increasingly common in soil and landscape restoration. Previous studies have demonstrated both beneficial and detrimental effects of this material on trace element mobility. A pot experiment with homogenised soil/compost investigated distribution and mobility of trace elements, two years after application of greenwaste compost mulch to shallow soils overlying a former alkali-works contaminated with Pb, Cu and As (approx900, 200 and 500 mg kg{sup -1}, respectively). Compost mulch increased organic carbon and Fe in soil pore water, which in turn increased As and Sb mobilization; this enhanced uptake by lettuce and sunflower. A very small proportion of the total soil trace element pool was in readily-exchangeable form (<0.01% As, <0.001% other trace elements), but the effect of compost on behaviour of metals was variable and ambiguous. It is concluded that greenwaste compost should be applied with caution to multi-element contaminated soils. - Arsenic solubility and bioavailability increases in soil two years after application of greenwaste compost mulch.

  15. Canine total knee replacement performed due to osteoarthritis subsequent to distal femur fracture osteosynthesis: two-year objective outcome.

    Science.gov (United States)

    Eskelinen, E V; Liska, W D; Hyytiäinen, H K; Hielm-Björkman, A

    2012-01-01

    A 27-kg German Shorthaired Pointer was referred for evaluation due to the complaint of left pelvic limb lameness and signs of pain in the left stifle joint. Radiographs revealed signs of a healed supracondylar femoral fracture that had been previously repaired at another hospital with an intramedullary pin and two cross pins. In addition, there were signs of severe osteoarthritis (OA). The OA had been managed medically with administration of carprofen and nutraceuticals for nine months without any improvement. Left total knee replacement (TKR) surgery was performed to alleviate signs of pain. The patient was assessed preoperatively and at six months, one year, and two years after surgery using radiology, force platform analysis of gait, thigh circumference measures, goniometry, and lameness evaluation. Following surgery, the dog resumed normal activity without any signs of pain and a good quality of life at 3.5 months. Force plate analysis found that peak vertical force on the TKR limb was 85.7% of the normal contralateral limb after two years. Total knee replacement was a successful treatment to manage knee OA associated with a healed distal femoral fracture and internal fixation in this dog.

  16. Children's emotional experience two years after an earthquake: An exploration of knowledge of earthquakes and associated emotions.

    Science.gov (United States)

    Raccanello, Daniela; Burro, Roberto; Hall, Rob

    2017-01-01

    We explored whether and how the exposure to a natural disaster such as the 2012 Emilia Romagna earthquake affected the development of children's emotional competence in terms of understanding, regulating, and expressing emotions, after two years, when compared with a control group not exposed to the earthquake. We also examined the role of class level and gender. The sample included two groups of children (n = 127) attending primary school: The experimental group (n = 65) experienced the 2012 Emilia Romagna earthquake, while the control group (n = 62) did not. The data collection took place two years after the earthquake, when children were seven or ten-year-olds. Beyond assessing the children's understanding of emotions and regulating abilities with standardized instruments, we employed semi-structured interviews to explore their knowledge of earthquakes and associated emotions, and a structured task on the intensity of some target emotions. We applied Generalized Linear Mixed Models. Exposure to the earthquake did not influence the understanding and regulation of emotions. The understanding of emotions varied according to class level and gender. Knowledge of earthquakes, emotional language, and emotions associated with earthquakes were, respectively, more complex, frequent, and intense for children who had experienced the earthquake, and at increasing ages. Our data extend the generalizability of theoretical models on children's psychological functioning following disasters, such as the dose-response model and the organizational-developmental model for child resilience, and provide further knowledge on children's emotional resources related to natural disasters, as a basis for planning educational prevention programs.

  17. The use of poplar during a two-year induced phytoextraction of metals from contaminated agricultural soils

    Energy Technology Data Exchange (ETDEWEB)

    Komarek, Michael [Department of Agrochemistry and Plant Nutrition, Czech University of Agriculture in Prague, Kamycka 129, 165 21, Prague 6 (Czech Republic)], E-mail: komarek@af.czu.cz; Tlustos, Pavel [Department of Agrochemistry and Plant Nutrition, Czech University of Agriculture in Prague, Kamycka 129, 165 21, Prague 6 (Czech Republic)], E-mail: tlustos@af.czu.cz; Szakova, Jirina [Department of Agrochemistry and Plant Nutrition, Czech University of Agriculture in Prague, Kamycka 129, 165 21, Prague 6 (Czech Republic)], E-mail: szakova@af.czu.cz; Chrastny, Vladislav [Department of Applied Chemistry and Chemistry Teaching, University of South Bohemia, Studentska 13, 370 05, Ceske Budejovice (Czech Republic)], E-mail: vladislavchrastny@seznam.cz

    2008-01-15

    The efficiency of poplar (Populus nigra L. x Populus maximowiczii Henry.) was assessed during a two-year chemically enhanced phytoextraction of metals from contaminated soils. The tested metal mobilizing agents were EDTA (ethylenediaminetetraacetic acid) and NH{sub 4}Cl. EDTA was more efficient than chlorides in solubilizing metals (especially Pb) from the soil matrix. The application of chlorides only increased the solubility of Cd and Zn. However, the increased uptake of metals after the application of higher concentrations of mobilizing agents was associated with low biomass yields of the poplar plants and the extraction efficiencies after the two vegetation periods were thus comparable to the untreated plants. Additionally, the application of mobilizing agents led to phytotoxicity effects and increased mobility of metals. Higher phytoextraction efficiencies were observed for Cd and Zn compared to Pb and Cu. Poplars are therefore not suitable for chemically enhanced phytoextraction of metals from severely contaminated agricultural soils. - Application of mobilizing agents is not optimal during a two-year phytoextraction of metals from severely contaminated soils using poplars.

  18. The use of poplar during a two-year induced phytoextraction of metals from contaminated agricultural soils

    International Nuclear Information System (INIS)

    Komarek, Michael; Tlustos, Pavel; Szakova, Jirina; Chrastny, Vladislav

    2008-01-01

    The efficiency of poplar (Populus nigra L. x Populus maximowiczii Henry.) was assessed during a two-year chemically enhanced phytoextraction of metals from contaminated soils. The tested metal mobilizing agents were EDTA (ethylenediaminetetraacetic acid) and NH 4 Cl. EDTA was more efficient than chlorides in solubilizing metals (especially Pb) from the soil matrix. The application of chlorides only increased the solubility of Cd and Zn. However, the increased uptake of metals after the application of higher concentrations of mobilizing agents was associated with low biomass yields of the poplar plants and the extraction efficiencies after the two vegetation periods were thus comparable to the untreated plants. Additionally, the application of mobilizing agents led to phytotoxicity effects and increased mobility of metals. Higher phytoextraction efficiencies were observed for Cd and Zn compared to Pb and Cu. Poplars are therefore not suitable for chemically enhanced phytoextraction of metals from severely contaminated agricultural soils. - Application of mobilizing agents is not optimal during a two-year phytoextraction of metals from severely contaminated soils using poplars

  19. Trace element mobility in a contaminated soil two years after field-amendment with a greenwaste compost mulch

    International Nuclear Information System (INIS)

    Clemente, Rafael; Hartley, William; Riby, Philip; Dickinson, Nicholas M.; Lepp, Nicholas W.

    2010-01-01

    Application of greenwaste compost to brownfield land is increasingly common in soil and landscape restoration. Previous studies have demonstrated both beneficial and detrimental effects of this material on trace element mobility. A pot experiment with homogenised soil/compost investigated distribution and mobility of trace elements, two years after application of greenwaste compost mulch to shallow soils overlying a former alkali-works contaminated with Pb, Cu and As (∼900, 200 and 500 mg kg -1 , respectively). Compost mulch increased organic carbon and Fe in soil pore water, which in turn increased As and Sb mobilization; this enhanced uptake by lettuce and sunflower. A very small proportion of the total soil trace element pool was in readily-exchangeable form (<0.01% As, <0.001% other trace elements), but the effect of compost on behaviour of metals was variable and ambiguous. It is concluded that greenwaste compost should be applied with caution to multi-element contaminated soils. - Arsenic solubility and bioavailability increases in soil two years after application of greenwaste compost mulch.

  20. The Impacts of Migraine among Outpatients with Major Depressive Disorder at a Two-Year Follow-Up

    Science.gov (United States)

    Hung, Ching-I; Liu, Chia-Yih; Yang, Ching-Hui; Wang, Shuu-Jiun

    2015-01-01

    Background No study has investigated the impacts of migraine on depression, anxiety, and somatic symptoms and remission at the two-year follow-up point among patients with major depressive disorder (MDD). This study aimed to investigate the above issues. Methods Psychiatric outpatients with MDD recruited at baseline were investigated at a two-year follow-up (N = 106). The Hamilton Depression Rating Scale, Hospital Anxiety and Depression Scale, and Depression and Somatic Symptoms Scale were used. Migraine was diagnosed according to the International Classification of Headache Disorders, 2nd edition. The patients were divided into no migraine, inactive migraine, and active migraine subgroups. Multiple logistic regressions were used to investigate the significant factors related to full remission of depression. Results Among patients without pharmacotherapy at the follow-up, patients with active migraine had significantly greater severities of anxiety and somatic symptoms as compared with patients without migraine; moreover, patients with active migraine had the lowest improvement percentage and full remission rate. There were no significant differences in depression, anxiety, and somatic symptoms between patients with inactive migraine and those without migraine. Active headache at follow-up was a significant factor related to a lower full remission rate. Conclusions Active headache at follow-up was associated with a lower rate of full remission and more residual anxiety and somatic symptoms at follow-up among patients with migraine. Physicians should integrate a treatment plan for depression and migraine for the treatment of patients with MDD. PMID:26000962

  1. Treatment of the calcific tendinopathy of the rotator cuff by ultrasound-guided percutaneous needle lavage. Two years prospective study

    Science.gov (United States)

    Castillo-González, Federico Del; Ramos-Álvarez, Juan José; Rodríguez-Fabián, Guillermo; González-Pérez, José; Calderón-Montero, Javier

    2014-01-01

    Summary Background: to evaluate the short and long term effectiveness of ultrasonography (US)-guided percutaneous needle lavage in calcific tendinopathy of the rotator cuff. To study the evolution of the size of calcifications and pain in the two years after treatment. Methods: study design: A 2 year longitudinal prospective study is carried out after applying the UGPL technique on a number of patients diagnosed with calcific tendinitis of the rotator cuff. Clinical, ultrasound and radiology follow-up controls were performed, 3 months, 6 months, one year and two years after the treatment. The Visual Analog Scale (VAS) was used to assess the pain. The degree and point of pain is selected on a 10 cm line, arranged horizontally or vertically. The “0” represents no pain and “10” represents worst pain. The population studied was made up of 121 patients that required our service as a result of suffering from a painful shoulder. Results: the pain (VAS) and the size of the calcification significantly decreased with the application of the technique (ptendinitis of the shoulder. The intervention is simple, cost-effective, does not require hospitalization, involves no complications, rehabilitation treatment is not required and it shows very few side effects without sequelae, significantly reducing the size of the calcification and pain in the majority of patients. PMID:25332939

  2. Serum concentrations of phthalate metabolites are related to abdominal fat distribution two years later in elderly women

    Directory of Open Access Journals (Sweden)

    Lind P Monica

    2012-04-01

    Full Text Available Abstract Background Phthalates, commonly used to soften plastic goods, are known PPAR-agonists affecting lipid metabolism and adipocytes in the experimental setting. We evaluated if circulating concentrations of phthalates were related to different indices of obesity using data from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS study. Data from both dual-energy X-ray absorptiometry (DXA and abdominal magnetic resonance imaging (MRI were used. Methods 1,016 subjects aged 70 years were investigated in the PIVUS study. Four phthalate metabolites were detected in the serum of almost all subjects (> 96% by an API 4000 liquid chromatograph/tandem mass spectrometer. Abdominal MRI was performed in a representative subsample of 287 subjects (28%, and a dual-energy X-ray absorptiometry (DXA-scan was obtained in 890 (88% of the subjects two year following the phthalate measurements. Results In women, circulating concentrations of mono-isobutyl phthalate (MiBP were positively related to waist circumference, total fat mass and trunk fat mass by DXA, as well as to subcutaneous adipose tissue by MRI following adjustment for serum cholesterol and triglycerides, education, smoking and exercise habits (all p Conclusions The present evaluation shows that especially the phthalate metabolite MiBP was related to increased fat amount in the subcutaneous abdominal region in women measured by DXA and MRI two years later.

  3. Oribatid Mite Community Decline Two Years after Low-Intensity Burning in the Southern Cascade Range of California, USA

    Directory of Open Access Journals (Sweden)

    Nancy E. Gillette

    2012-10-01

    Full Text Available To assess effects of low-intensity fire, we combined two silvicultural prescriptions with prescribed fire in the California Cascade Range. In the first treatment, two 100-ha stands were thinned to reduce density while retaining old-growth structural characteristics, yielding residual stands with high structural diversity (HSD. Two other 100-ha plots were thinned to minimize old growth structure, producing even-aged stands of low structural diversity (LSD, and one 50-ha split-plot from each treatment was burned. In addition, two 50 ha old-growth Research Natural Areas (RNA were selected as untreated reference plots, one of which was also burned. Fire treatments profoundly altered mite assemblages in the short term, and forest structure modification likely exacerbated that response. Sampling conducted two years following treatment confirmed a continuing decline in oribatid mite abundance. Oribatid species richness and assemblage heterogeneity also declined, and community dominance patterns were disrupted. Oribatid responses to fire were either more intense or began earlier in the LSD treatments, suggesting that removal of old-growth structure exacerbated mite responses to fire. Prostigmatids recovered quickly, but their populations nonetheless diminished significantly in burned split-plots. Mite assemblage responses to prescribed fire were continuing nearly two years later, with no clear evidence of recovery.

  4. Two-year study relating adolescents' self-concept and gender role perceptions to achievement and attitudes toward science

    Science.gov (United States)

    Handley, Herbert M.; Morse, Linda W.

    To assess the developmental relationship of perceptions of self-concept and gender role identification with adolescents' attitudes and achievement in science, a two-year longitudinal study was conducted. A battery of instruments assessing 16 dimensions of self-concept/gender role identifications was employed to predict students' achievement and attitudes toward science. Specific behaviors studied included self-concept in school and science and mathematics, attitudes toward appropriate gender roles in science activities and careers, and self-perceptions of masculine and feminine traits. One hundred and fifty-five adolescents, enrolled, respectively, in the seventh and eighth grades, participated in the study. Through Fisher z transformations of correlation coefficients, differences in relationships between these two sets of variables were studied for males and females during the two years. Results indicated that students' self-concepts/gender role perceptions were related to both achievement and attitudes toward science, but more related to attitudes than achievement. These relationships became more pronounced for students as they matured from seventh to eighth graders.

  5. A Two Year Longitudinal Outcome Study of Addicted Health Care Professionals: An Investigation of the Role of Personality Variables

    Directory of Open Access Journals (Sweden)

    Daniel Angres

    2013-01-01

    Full Text Available The co-morbidity of personality disorders (PDs and other dysregulatory personality patterns with addiction have been well-established, although few studies have examined this interplay on long-term sobriety outcome. In addition, health care professionals suffering from addiction have both a significant public health impact and a unique set of treatment and recovery challenges. The aim of this study was to investigate if personality variables differentiated sobriety outcome in this population over a two year interval. A clinical sample of health care professionals participated in a substance abuse hospital treatment program individually tailored with respect to personality. Participants took the Temperament and Character Inventory and the Millon Clinical Multiaxial Inventory at intake, and were tracked two years post-discharge to determine sobriety status. Univariate analyses showed antisocial personality, female gender, and alcohol dependence were independent predictors of relapse, however a significant relationship between personality and substance use did not exist in multivariate analysis when controlling for demographic variables The lack of multivariate relationships demonstrates the heterogeneity in self-report measures of personality, which suggests the interplay of personality and addiction is complex and individualized.

  6. Dual enrollment as a factor for women transitioning into STEM majors in Montana two-year colleges

    Science.gov (United States)

    Jakes, Penny Jane

    The purpose of this non-experimental, descriptive, quantitative study was to describe the impact high school dual enrollment coursework has had on initial enrollment of women with STEM majors in Montana two-year colleges. The study was designed to find whether or not differences existed for access (initial enrollment), persistence (to third semester), and success (associate's degree, certificate, or transfer to a four-year institution within 150% of program length). The literature review highlighted the need for studies to address the issue of few women in science, technology, engineering, and mathematics (STEM) occupations. One goal of dual enrollment in Montana is to ease transitions from high school to college, including underrepresented populations such as women in STEM fields. The scope of this study was to collect, organize, and interpret data to describe the effect of that effort for women enrolling in STEM majors at two-year colleges in Montana. Baseline information established the demographics of young women who participated in dual enrollment in Montana high schools during 2007-2009. Data analysis described results using attributes of gender, dual enrollment, access, persistence, and success for those enrolled in STEM fields. Results indicated more young women than young men take advantage of dual enrollment in high school and more women than men with dual-enrollment credit initially enroll in college. More men than women major in a STEM field and more men persist and graduate within the STEM fields. Data indicated that 221 students enrolled in a Montana two-year college with DE/DC credit during 2007-2009. Of those, eight women chose STEM majors, six persisted to the third semester, and two completed. It is recommended that a mixed-methods study be conducted to give a deeper level of understanding for enrollment trends and career choice. Longitudinal studies should also be conducted as dual enrollment grows within the state of Montana. Further studies

  7. Cystic Adventitial Disease of Popliteal Artery with Venous Aneurysm of Popliteal Vein: Two-Year Follow-Up after Surgery

    Directory of Open Access Journals (Sweden)

    Koki Takizawa

    2017-01-01

    Full Text Available We report a rare case of cystic adventitial disease of popliteal artery with venous aneurysm of popliteal vein. A 46-year-old woman had sudden-onset intermittent claudication and coldness in her right leg. The right-sided ankle-brachial pressure index (ABI was 1.01, but peripheral arterial pulsation was decreased at knee venting position. Computed tomography revealed simple cystic lesion of the popliteal artery and stenosis of the arterial lumen in this lesion. The patient was treated by complete resection of the cystic adventitial layer of popliteal artery. A venous aneurysm of popliteal vein was revealed by intraoperative echo and was simply ligated. The patient had uneventful postoperative course and no symptoms of relevance during the two years of follow-up.

  8. Prenatal control of Hb Bart's hydrops fetalis: a two-year experience at a mainland Chinese hospital.

    Science.gov (United States)

    Liao, Can; Pan, Min; Han, Jin; Yang, Xin; Zhen, Li; Li, Jian; Li, Ru; Li, Dong-Zhi

    2015-03-01

    α-Thalassemia is a common inherited disease in southern China. The severest form is Hb Bart's hydrops fetalis, in which the affected fetuses almost always die in utero or shortly after birth, and the mothers are at high risk for severe morbidity. Therefore, this condition should be controlled, especially prenatally. In this study, we reported on a two-year experience in prenatal control of Hb Bart's hydrops fetalis at a mainland Chinese hospital. Totally, 573 pregnancies at risk for Hb Bart's hydrops fetalis were referred and different prenatal procedures were offered depending on the gestational age at presentation. One hundred fifty-two affected fetuses were diagnosed prenatally; among these, only half presented in early gestation, and were terminated in time. Although our prenatal program has successfully prevented the birth of children with severe thalassemia, it does not show a satisfactory outcome, considering the gestational age when an affected pregnancy is terminated.

  9. Results of two years of water training on jump height in postmenopausal women with moderate hip risk fracture

    Directory of Open Access Journals (Sweden)

    María Carrasco Poyatos

    2010-01-01

    Full Text Available The aim of the present study was to investigate the effect of a water-based calisthenics and resistance program on jump height in postmenopausal women with moderate hip risk fracture. 39 women were divided into three groups: swimming group (GN; n = 17, calisthenics and resistance group (GIR; n = 14, and control group (GC; n = 8. Body composition test included body mass index (IMC and waist to hip ratio (ICC. Jump height was assessed by a countermovement jump (CMJ. GN showed a significant (p<0.05 decrease in ICC (5.81%. GIR showed a significant decrease in IMC (3.65% and a significant increase in CMJ (15.5%. Two years of water-based calisthenics and resistance training can offer significant benefits in jump height in postmenopausal women with moderate hip risk fracture. Both exercise programs can also improve body composition.

  10. Two years' outcome of thread lifting with absorbable barbed PDO threads: Innovative score for objective and subjective assessment.

    Science.gov (United States)

    Ali, Yasser Helmy

    2018-02-01

    Thread-lifting rejuvenation procedures have evolved again, with the development of absorbable threads. Although they have gained popularity among plastic surgeons and dermatologists, very few articles have been written in literature about absorbable threads. This study aims to evaluate two years' outcome of thread lifting using absorbable barbed threads for facial rejuvenation. Prospective comparative stud both objectively and subjectively and follow-up assessment for 24 months. Thread lifting for face rejuvenation has significant long-lasting effects that include skin lifting from 3-10 mm and high degree of patients' satisfaction with less incidence rate of complications, about 4.8%. Augmented results are obtained when thread lifting is combined with other lifting and rejuvenation modalities. Significant facial rejuvenation is achieved by thread lifting and highly augmented results are observed when they are combined with Botox, fillers, and/or platelet rich plasma (PRP) rejuvenations.

  11. [Isokinetic assessment with two years follow-up of anterior cruciate ligament reconstruction with patellar tendon or hamstring tendons].

    Science.gov (United States)

    Condouret, J; Cohn, J; Ferret, J-M; Lemonsu, A; Vasconcelos, W; Dejour, D; Potel, J-F

    2008-12-01

    This retrospective multicentric study was designed to assess the outcome of quadriceps and hamstrings muscles two years after Anterior Cruciate Ligament (ACL) reconstruction and compare muscles recovery depending on the type of graft and individual variables like age, gender, level of sport, but also in terms of discomfort, pain and functional score. The results focused on the subjective and objective IKDC scores, SF36, the existence or not of subjective disorders and their location. The review included isokinetic muscle tests concentric and eccentric extensors/flexors but also internal rotators/external rotators with analysis of mean work and mean power. One hundred and twenty-seven patients were included with an average age 29 years (+/-10). They all had an ACL reconstruction with patellar tendon or hamstring tendon with single or double bundles. In the serie, the average muscles deficit at two years was 10% for the flexors and extensors but with a significant dispersion. Significant differences were not noted in the mean values of all parameters in term of sex or age (over 30 years or not), neither the type of sport, nor of clinical assessment (Class A and B of objective IKDC score), nor the existence of anterior knee pain. There was a relationship between the level of extensor or flexor recovery and the quality of functional results with minimal muscle deficits close to 5% if the IKDC score was over 90 and deficits falling to 15% in the group with IKDC score less than 90. The type of reconstruction (patellar tendon versus hamstrings) had an influence on the muscle deficit. For extensors, the recovery was the same in the two groups, more than 90% at two years and the distribution of these two populations by level of deficit was quite the same. For flexors, residual deficits were significantly higher in the hamstrings group on the three studied parameters whatever the speed and the type of contraction (concentric or eccentric) with an average deficit of 14 to 18

  12. Two years of gender identity service for minors: overrepresentation of natal girls with severe problems in adolescent development.

    Science.gov (United States)

    Kaltiala-Heino, Riittakerttu; Sumia, Maria; Työläjärvi, Marja; Lindberg, Nina

    2015-01-01

    Increasing numbers of adolescents present in adolescent gender identity services, desiring sex reassignment (SR). The aim of this study is to describe the adolescent applicants for legal and medical sex reassignment during the first two years of adolescent gender identity team in Finland, in terms of sociodemographic, psychiatric and gender identity related factors and adolescent development. Structured quantitative retrospective chart review and qualitative analysis of case files of all adolescent SR applicants who entered the assessment by the end of 2013. The number of referrals exceeded expectations in light of epidemiological knowledge. Natal girls were markedly overrepresented among applicants. Severe psychopathology preceding onset of gender dysphoria was common. Autism spectrum problems were very common. The findings do not fit the commonly accepted image of a gender dysphoric minor. Treatment guidelines need to consider gender dysphoria in minors in the context of severe psychopathology and developmental difficulties.

  13. Perofrmance testing of personnel dosimetry services. Final report of a two-year pilot study, October 1977-September 1979

    International Nuclear Information System (INIS)

    Plato, P.; Hudson, G.

    1980-01-01

    A two-year pilot study was conducted of the Health Physics Society Standards Committee (HPSSC) Standard titled, Criteria for Testing Personnel Dosimetry Performance. The objectives of the pilot study were: to give processors an opportunity to correct any problems that are uncovered; to develop operational and administrative prodedures to be used later by a permanent testing laboratory; and to determine whether the proposed HPSSC Standard provides an adequate and practical test of dosimetry performance. Fifty-nine dosimetry processors volunteered to submit dosimeters for test irradiations according to the requirements of the HPSSC Standard. The feasibility of using the HPSSC Standard for a future mandatory testing program for personnel dosimetry processors is discussed. This report shows the results of the pilot study and contains recommendations for revisions in the Standard that will make a mandatory testing program useful to regulatory agencies, dosimetry processors, and radiation workers that use personnel dosimeters

  14. Thirty-two years of Acta Neophilologica - with gratitude to its founder and editor Professor Janez Stanonik

    Directory of Open Access Journals (Sweden)

    Mirko Jurak

    2000-12-01

    Full Text Available In spring this year Professor Janez Stanonik decided to retire as the Editor of the scholarly journal Acta Neophilologica, which he founded in 1968 and edited for thirty-two years. I endeavoured to help him with the material side of the journal from the very beginning until1995; since then this task has been performed by the present Associate Editor. At the time when Janez Stanonik began publishing this journal, his main aim was to make our research work in Western European and American literature better known to scholars all over the world. However, in a few years' time the journal also became open to scholars from other countries and other fields, particularly in areas connected with Slovene literature and culture, Slovene immigrant literature, and linguistics. I believe that this approach gave the journal a new openness and that it enriched its quality, therefore I intend to follow this policy in the future too.

  15. Preterm brain injury on term-equivalent age MRI in relation to perinatal factors and neurodevelopmental outcome at two years.

    Directory of Open Access Journals (Sweden)

    Margaretha J Brouwer

    Full Text Available First, to apply a recently extended scoring system for preterm brain injury at term-equivalent age (TEA-MRI in a regional extremely preterm cohort; second, to identify independent perinatal factors associated with this score; and third, to assess the prognostic value of this TEA-MRI score with respect to early neurodevelopmental outcome.239 extremely preterm infants (median gestational age [range] in weeks: 26.6 [24.3-27.9], admitted to the Wilhelmina Children's Hospital between 2006 and 2012 were included. Brain abnormalities in white matter, cortical and deep grey matter and cerebellum and brain growth were scored on T1- and T2-weighted TEA-MRI using the Kidokoro scoring system. Neurodevelopmental outcome was assessed at two years corrected age using the Bayley Scales of Infant and Toddler Development, third edition. The association between TEA-MRI and perinatal factors as well as neurodevelopmental outcome was evaluated using multivariable regression analysis.The distribution of brain abnormalities and brain metrics in the Utrecht cohort differed from the original St. Louis cohort (p 7 days (β [95% confidence interval, CI]: 1.3 [.5; 2.0] and parenteral nutrition >21 days (2.2 [1.2; 3.2] were independently associated with higher global brain abnormality scores (p < .001. Global brain abnormality scores were inversely associated with cognitive (β in composite scores [95% CI]: -.7 [-1.2; -.2], p = .004, fine motor (β in scaled scores [95% CI]: -.1 [-.3; -.0], p = .007 and gross motor outcome (β in scaled scores [95% CI]: -.2 [-.3; -.1], p < .001 at two years corrected age, although the explained variances were low (R2 ≤.219.Patterns of brain injury differed between cohorts. Prolonged mechanical ventilation and parenteral nutrition were identified as independent perinatal risk factors. The prognostic value of the TEA-MRI score was rather limited in this well-performing cohort.

  16. Learning, Memory, and Executive Function in New MDMA Users: A Two-Year Follow-up Study

    Directory of Open Access Journals (Sweden)

    Daniel eWagner

    2015-12-01

    Full Text Available 3,4-Methylenedioxymethamphetamine (MDMA is associated with changes in neurocognitive performance. Recent studies in laboratory animals have provided additional support for the neurodegeneration hypothesis. However, results from animal research need to be applied to humans with caution. Moreover, several of the studies that examine MDMA users suffer from methodological shortcomings. Therefore, a prospective cohort study was designed in order to overcome these previous methodological shortcomings and to assess the relationship between the continuing use of MDMA and cognitive performance in incipient MDMA users. It was hypothesized that, depending on the amount of MDMA taken, the continued use of MDMA over a two-year period would lead to further decreases in cognitive performance, especially in visual paired association learning tasks. 96 subjects were assessed at the second follow-up assessment: 31 of these were non-users, 55 moderate-users and 10 heavy-users. Separate repeated measures analyses of variance were conducted for each cognitive domain, including attention and information processing speed, episodic memory and executive functioning. Furthermore, possible confounders including age, general intelligence, cannabis use, alcohol use, use of other concomitant substances, recent medical treatment, participation in sports, level of nutrition, sleep patterns and subjective well-being were assessed.The Repeated measures analysis of variance (rANOVA revealed that a marginally significant change in immediate and delayed recall test performances of visual paired associates learning had taken place within the follow-up period of two years. No significant differences with the other neuropsychological tests were noted. It seems that MDMA use can impair visual paired associates learning in new users. However, in the recent study, further deterioration in continuing MDMA-users was not observed.

  17. Mortality, neonatal morbidity and two year follow-up of extremely preterm infants born in The Netherlands in 2007.

    Directory of Open Access Journals (Sweden)

    Cornelia G de Waal

    Full Text Available Extremely preterm infants are at high risk of neonatal mortality and adverse outcome. Survival rates are slowly improving, but increased survival may come at the expense of more handicaps.Prospective population-based cohort study of all infants born at 23 to 27 weeks of gestation in The Netherlands in 2007. 276 of 345 (80% infants were born alive. Early neonatal death occurred in 96 (34.8% live born infants, including 61 cases of delivery room death. 29 (10.5% infants died during the late neonatal period. Survival rates for live born infants at 23, 24, 25 and 26 weeks of gestation were 0%, 6.7%, 57.9% and 71% respectively. 43.1% of 144 surviving infants developed severe neonatal morbidity (retinopathy of prematurity grade ≥3, bronchopulmonary dysplasia and/or severe brain injury. At two years of age 70.6% of the children had no disability, 17.6% was mild disabled and 11.8% had a moderate-to-severe disability. Severe brain injury (p = 0.028, retinopathy of prematurity grade ≥3 (p = 0.024, low gestational age (p = 0.019 and non-Dutch nationality of the mother (p = 0.004 increased the risk of disability.52% of extremely preterm infants born in The Netherlands in 2007 survived. Surviving infants had less severe neonatal morbidity compared to previous studies. At two years of age less than 30% of the infants were disabled. Disability was associated with gestational age and neonatal morbidity.

  18. Quality control of CT systems by automated monitoring of key performance indicators: a two-year study.

    Science.gov (United States)

    Nowik, Patrik; Bujila, Robert; Poludniowski, Gavin; Fransson, Annette

    2015-07-08

    The purpose of this study was to develop a method of performing routine periodical quality controls (QC) of CT systems by automatically analyzing key performance indicators (KPIs), obtainable from images of manufacturers' quality assurance (QA) phantoms. A KPI pertains to a measurable or determinable QC parameter that is influenced by other underlying fundamental QC parameters. The established KPIs are based on relationships between existing QC parameters used in the annual testing program of CT scanners at the Karolinska University Hospital in Stockholm, Sweden. The KPIs include positioning, image noise, uniformity, homogeneity, the CT number of water, and the CT number of air. An application (MonitorCT) was developed to automatically evaluate phantom images in terms of the established KPIs. The developed methodology has been used for two years in clinical routine, where CT technologists perform daily scans of the manufacturer's QA phantom and automatically send the images to MonitorCT for KPI evaluation. In the cases where results were out of tolerance, actions could be initiated in less than 10 min. 900 QC scans from two CT scanners have been collected and analyzed over the two-year period that MonitorCT has been active. Two types of errors have been registered in this period: a ring artifact was discovered with the image noise test, and a calibration error was detected multiple times with the CT number test. In both cases, results were outside the tolerances defined for MonitorCT, as well as by the vendor. Automated monitoring of KPIs is a powerful tool that can be used to supplement established QC methodologies. Medical physicists and other professionals concerned with the performance of a CT system will, using such methods, have access to comprehensive data on the current and historical (trend) status of the system such that swift actions can be taken in order to ensure the quality of the CT examinations, patient safety, and minimal disruption of service.

  19. Two-Year Operational Evaluation Of A Consumer Electronics-Based Data Acquisition System For Equipment Monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Van Hoy, Blake W. [ORNL; Phillips, Larry D. [ORNL; Wetherington Jr, G Randall [ORNL; Damiano, Brian [ORNL; Green, Craig [ORNL

    2017-04-01

    Oak Ridge National Laboratory (ORNL) has performed a two-year evaluation of the performance of an in-house developed consumer electronics-based data acquisition system (DAS). The main advantage of this approach compared to conventional instrumentation grade systems is cost; instrument grade data acquisition systems average costs range from $800 to $2,000 per channel compared to a range of $200 - $400 per channel for a consumer electronics-based system. The DAS is operated as a full-time in-situ vibration monitor. The resulting data stream is streamed over the ORNL network, at an aggregate rate of approximately 2 megabytes/s, to a Linux server. The server includes the capability to implement event-triggered data stores, as well as real-time files for the implementation of continuous display monitoring of the spectra. Detailed spectral analysis is performed post event. The DAS is installed on a large industrial chiller and cooling water pump associated with ORNL’s Titan supercomputer. These mechanical systems include rotating components that operate at fundamental frequencies within the range of 30 Hz to over 3 KHz. Evaluation of the DAS data over a two-year operating period leads to the conclusion that for many industrial processes this system could form the basis for a cost effective means of obtaining operating health data in real time from rotating machinery. The deployment has also shown that the DAS technology is reliable. Furthermore, because the cost of the DAS is low, the other significant advantage of this approach is that the DAS can be deployed in a dedicated manner and operated on a full-time basis.

  20. Patellofemoral arthritis treated with resurfacing implant: Clinical outcome and complications at a minimum two-year follow-up.

    Science.gov (United States)

    Zicaro, Juan Pablo; Yacuzzi, Carlos; Astoul Bonorino, Juan; Carbo, Lisandro; Costa-Paz, Matias

    2017-12-01

    This study evaluated the clinical and radiographic outcomes of a series of patients treated with an anatomic inlay resurfacing implant, with a minimum two-year follow-up. Fifteen patients underwent patellofemoral-resurfacing procedures using a HemiCAP Wave Patellofemoral Inlay Resurfacing implant from 2010 to 2013. Clinical outcomes included: Visual Analog Scale (VAS), Lysholm score, Knee Society Score (KSS), and evaluation of Kujala, and Hospital for Special Surgery Patellofemoral score (HSS-PF). The postoperative complications were analyzed. Nineteen knees were evaluated; the average follow-up was 35.2months. Fourteen were women, with an average age of 54years. The pre-operative/postoperative clinical results presented a significant improvement: VAS 8/2.5, Lysholm 31.9/85.8, KSS 39.8/82.5, Kujala 32.1/79.3 and Hospital for Special Surgery Patellofemoral score (HSS-PF) 15.9/90.6. A total of 87% of patients were either satisfied or very satisfied with the overall outcome. There were no radiographic signs of loosening. Seven postoperative complications were recorded: two presented ongoing knee pain, one postoperative stiffness, one patellar bounce due to maltracking, two ilio-tibial band syndrome, and one tibial anterior tuberosity osteotomy nonunion. Two patients underwent a total knee arthroplasty conversion and were considered a failure. None of these complications were implant related. Patellofemoral inlay resurfacing for isolated patellofemoral arthritis was an effective and safe procedure with high levels of patient satisfaction. No mechanical implant failure was seen at a minimum two-year follow-up. This implant design appeared to be an alternative to the traditional patellofemoral prostheses. Concomitant osteochondral lesions, patellofemoral dysplasia or patellar maltracking might be poor prognostic factors for this type of implant. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Radioadaptive response: the results of a two-year follow-up study on a non-responder

    International Nuclear Information System (INIS)

    Mortazavi, Javad S M.; Ikushima, Takaji

    2001-01-01

    Scientists have been aware for many years that low doses of ionizing radiation may cause some changes in the cells and organisms, which lead to an adaptation to the detrimental effects of relatively high doses of radiation. In spite of the fact that human lymphocytes exposed in vivo to different adapting doses show a radioadaptive response (e.g. induction of radioadaptive response in radiation workers, residents of the contaminated areas after Chernobyl accident or the inhabitants of high background radiation areas), it is still an open question why the radioadaptive response cannot be induced in the lymphocytes of some individuals. We and other investigators reported that some non-responders showed a significant increase in the frequency of chromosome aberrations after an adapting dose. Considering the fact that we still don't know the frequency of non-responders in the population, any implication of radioadaptive response in the estimation of the risks of low-level exposure would be problematical. In this paper, we present the results of our two-year follow-up study on a non-responder. In 1998, we found out that one of the blood donors did not show radioadaptive response in any experiments. Interestingly, in some cases the donor's lymphocytes showed a strong synergistic effect after exposure to an adapting dose. As it was claimed that the existence or lack of radioadaptive response is possibly dependent on some transient physiological parameters, we evaluated the responses of this donor to a common adapting dose in a two-year follow-up study. The results showed that non-responsiveness was not a transient phenomenon. The non-responder donor never showed a radioadaptive response despite some changes in the magnitude of the synergistic effect induced by an adapting dose. These results suggest that the non-responsiveness of this donor is probably determined by some non-transient biological factors such as the genetic constitution. (authors)

  2. Two-year survival and neurodevelopmental outcomes after cardiopulmonary resuscitation in neonatal patients after complex cardiac surgery.

    Science.gov (United States)

    Hansen, Gregory; Joffe, Ari R; Nettel-Aguirre, Alberto; Robertson, Charlene M T; Biggs, Wayne S G; Ross, David B; Rebeyka, Ivan M

    2011-03-01

    To examine survival and neurodevelopmental outcomes in neonates having post-operative cardiopulmonary resuscitation (CPR). This inception cohort study included all neonates (6 weeks old or less) who received postoperative CPR (Group 1) after cardiac surgery from 1996 to 2005, matched for heart defect, year of surgery, chromosomal abnormality, and socioeconomic status to two neonates who did not receive postoperative CPR (Group 2). Two-year neurodevelopment was prospectively assessed with Bayley Scales of Infant Development II and Adaptive Behavior Assessment System II. Pre-, intra-, and post-operative variables were collected prospectively. Cardiac arrest variables were collected retrospectively. Predictors of mortality were analyzed by univariate analysis and conditional multiple logistic regression. There were 29 patients in Group 1, and 58 patients in Group 2. In survivors, there were no significant differences between Groups 1 and 2 in outcomes [mean (SD)] of mental developmental index [84.5 (12.2) vs. 81.0 (18.9)], psychomotor developmental index [82.8 (13.8) vs. 80.1 (21.9)], General Adaptive Composite [84.6 (15.3) vs. 84.3 (19.2)], Motor scale [8.4 (3.2) vs. 8.0 (3.8)], or delay on any of these scales. Two-year mortality [58.6% Group 1; 8.6% Group 2], was associated on conditional multiple logistic regression with CPR (OR 26.6; 95% CI, 5.4, 129.5). In Group 1, on multiple logistic regression, 2-year mortality was associated with minutes of chest compressions (OR 1.04, 95% CI, 1.01, 1.08). Among neonates having cardiac surgery, CPR is associated with greater mortality. There is no evidence that CPR survivors have different 2-year neurodevelopmental outcomes than those neonates not having CPR. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  3. A STUDY OF MORPHOLOGICAL TYPES OF ANAEMIA IN A TERTIARY CARE HOSPITAL - A TWO-YEAR STUDY

    Directory of Open Access Journals (Sweden)

    Kiran Kumar Epari

    2016-08-01

    Full Text Available BACKGROUND In this tertiary care hospital, one of the common condition of all the patients attending the hospital is Anaemia, which is a decrease in haemoglobin content or decrease in haematocrit below the lower limit of the 95% reference range for the individual’s age and sex. The patient presents with varied symptoms of different grades, depending on the severity of anaemia, in different clinical settings. Common presenting symptoms of anaemia are generalised weakness, malaise, loss of appetite and muscular pains. METHODS All the patient samples received at the central laboratory for haemogram, complete blood counts and peripheral smear examination over the period of two years between June 2014 to May 2016 were included in the study. Anaemia cases were diagnosed depending on the criteria of the definition of anaemia, and morphological typing of anaemia was done based on the peripheral smear examination of all the cases with decreased haemoglobin level. Standard cell counter was used to estimate the Hb and other red cell indices, and corroborated with peripheral blood smear examination by standard Romanowsky stains. RESULTS A total of 810 cases of anaemia were diagnosed over the period of two years, of which morphological typing yielded 685 cases of Microcytic and hypochromic anaemia, 15 cases of Dimorphic anaemia, 22 cases of Macrocytic anaemia and 88 cases of Normocytic and normochromic anaemia. CONCLUSION Anaemia is one of the most common problems of patients attending this tertiary care hospital, and detection and morphological typing of anaemia is very helping in guiding the clinicians in diagnosis and further management of anaemias for better patient care.

  4. Work satisfaction and dissatisfaction--caregivers' experiences after a two-year intervention in a newly opened nursing home.

    Science.gov (United States)

    Häggström, Elisabeth; Skovdahl, Kirsti; Fläckman, Birgitta; Kihlgren, Annika L; Kihlgren, Mona

    2005-01-01

    The aim of the study was to investigate, from the narratives of nine enrolled nurses and one nurses' aide directly involved in patient care, the deeper meaning of work satisfaction and dissatisfaction when working with the older people. Both nationally and internationally, there is little research documented regarding the working situation of the enrolled nurses and nurses' aides who make up the majority of care for older people today. With this in mind, it is important to focus on how these occupational groups experience their work with the older residents in municipal care, following a two-year intervention. The study is part of a larger longitudinal study, with a quasi-experimental design within the municipal system of care for older people in Sweden. The investigation was carried out following a two-year intervention, which included: education, support and clinical supervision. The interviews were performed 12 and 24 months after start of the intervention and were analysed with a phenomenological-hermeneutic method inspired by Ricoeur's philosophy. The findings from these narratives illustrated a change compared with the findings from the first interviews, when the nursing home had just opened. There was a shift from a dominance of dissatisfaction with work, to a dominance of work satisfaction and this was expressed in the following themes: experience of a changed perspective, experience of open doors, and experience of closed doors. Each theme emerged from several different subthemes and each subtheme that had been expressed in the caregivers' narratives was interpreted. The study shows that the caregivers' experience of work satisfaction in the workplace exceeded their experience of dissatisfaction and that the intervention, consisting of: education, support, and supervision might have facilitated this positive development where the older residents were prioritized. It also shows that communication and understanding between management and staff had increased

  5. Two-year drinking water carcinogenicity study of methyl tertiary-butyl ether (MTBE) in Wistar rats.

    Science.gov (United States)

    Dodd, Darol; Willson, Gabrielle; Parkinson, Horace; Bermudez, Edilberto

    2013-07-01

    Methyl tertiary-butyl ether (MTBE) has been used as a gasoline additive to reduce tailpipe emissions and its use has been discontinued. There remains a concern that drinking water sources have been contaminated with MTBE. A two-year drinking water carcinogenicity study of MTBE was conducted in Wistar rats (males, 0, 0.5, 3, 7.5 mg ml(-1); and females, 0, 0.5, 3, and 15 mg ml(-1)). Body weights were unaffected and water consumption was reduced in MTBE-exposed males and females. Wet weights of male kidneys were increased at the end of two years of exposure to 7.5 mg ml(-1) MTBE. Chronic progressive nephropathy was observed in males and females, was more severe in males, and was exacerbated in the high MTBE exposure groups. Brain was the only tissue with a statistically significant finding of neoplasms. One astrocytoma (1/50) was found in a female rat (15 mg ml(-1)). The incidence of brain astrocytomas in male rats was 1/50, 1/50, 1/50 and 4/50 for the 0, 0.5, 3 and 7.5 mg ml(-1) exposure groups, respectively. This was a marginally significant statistical trend, but not statistically significant when pairwise comparisons were made or when multiple comparisons were taken into account. The incidence of astrocytoma fell within historical control ranges for Wistar rats, and the brain has not been identified as a target organ following chronic administration of MTBE, ethyl tert-butyl ether, or tertiary butyl alcohol (in drinking water) to mice and rats. We conclude that the astrocytomas observed in this study are not associated with exposure to MTBE. Copyright © 2011 John Wiley & Sons, Ltd.

  6. Effect evaluation of a two-year complex intervention to reduce loneliness in non-institutionalised elderly Dutch people.

    Science.gov (United States)

    Honigh-de Vlaming, Rianne; Haveman-Nies, Annemien; Heinrich, Judith; van't Veer, Pieter; de Groot, Lisette C P G M

    2013-10-21

    Public health policy calls for intervention programmes to reduce loneliness in the ageing population. So far, numerous loneliness interventions have been developed, with effectiveness demonstrated for few of these interventions. The loneliness intervention described in this manuscript distinguishes itself from others by including multiple intervention components and targeting individuals and their environment. Intervention components included a mass media campaign, information meetings, psychosocial group courses, social activities organised by neighbours, and training of intermediaries. The aim of this manuscript is to study the effects of this integrated approach on initial and long-term outcomes. A quasi-experimental pre-test post-test intervention study was conducted among non-institutionalised elderly people aged 65 years and over to evaluate the effectiveness of the intervention by comparing the intervention community and the control community. Data on outputs, initial and long-term outcomes, and the overall goal were collected by self-administered questionnaires. Data of 858 elderly people were available for the analyses. To assess the effect linear regression analyses with adjustments for age, gender, church attendance, and mental health were used. In addition, the process evaluation provided information about the reach of the intervention components. After two years, 39% of the elderly people were familiar with the intervention programme. The intervention group scored more favourably than the control group on three subscales of the initial outcome, motivation (-4.4%, 95% CI-8.3--0.7), perceived social support (-8.2%, 95% CI-13.6--2.4), and subjective norm (-11.5%, 95% CI-17.4--5.4). However, no overall effects were observed for the long-term outcome, social support, and overall goal, loneliness. Two years after its initiation the reach of the intervention programme was modest. Though no effect of the complex intervention was found on social support and

  7. Dementia as a determinant of social and health service use in the last two years of life 1996-2003

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    Raitanen Jani

    2011-04-01

    Full Text Available Abstract Background Dementia is one of the most common causes of death among old people in Finland and other countries with high life expectancies. Dementing illnesses are the most important disease group behind the need for long-term care and therefore place a considerable burden on the health and social care system. The aim of this study was to assess the effects of dementia and year of death (1998-2003 on health and social service use in the last two years of life among old people. Methods The data were derived from multiple national registers in Finland and comprise all those who died in 1998, 2002 or 2003 and 40% of those who died in 1999-2001 at the age of 70 or over (n = 145 944. We studied the use of hospitals, long-term care and home care in the last two years of life. Statistics were performed using binary logistic regression analyses and negative binomial regression analyses, adjusting for age, gender and comorbidity. Results The proportion of study participants with a dementia diagnosis was 23.5%. People with dementia diagnosis used long-term care more often (OR 9.30, 95% CI 8.60, 10.06 but hospital (OR 0.33, 95% CI 0.31, 0.35 and home care (OR 0.50, 95% CI 0.46, 0.54 less often than people without dementia. The likelihood of using university hospital and long-term care increased during the eight-year study period, while the number of days spent in university and general hospital among the users decreased. Differences in service use between people with and without dementia decreased during the study period. Conclusions Old people with dementia used long-term care to a much greater extent and hospital and home care to a lesser extent than those without dementia. This difference persisted even when controlling for age, gender and comorbidity. It is important that greater attention is paid to ensuring that old people with dementia have equitable access to care.

  8. Pilot phase evaluation of the elective general practice class: results of student surveys of the first two years

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    Samos, Franziska-Antonia

    2017-02-01

    Full Text Available Background: Primary health care in rural regions is currently undergoing a global crisis in respect of the next generation of practitioners. National and international recommendations advise placing greater emphasis upon practical skills and competences in medical studies. It is also in the interest of training the next generation to include mentoring and longitudinal integration of contact to teaching practices for general medicine in an early stage. Consequently, the (KAM was introduced in Halle in 2011 as an elective with 20 individually mentored students per year, beginning with the first subject-related semester. We are now reporting on the results of the evaluation for the first two years. Method: A standardised online survey was carried out with all students who took part in the KAM in the two years 2011 and 2012 (N=38. For both years the survey was made at the end of the first summer semester on the basis of an adapted version of the and the . Furthermore, each year the preference for the choice of specialty and location of a medical practice was queried. Predictors for the preference of the chosen specialty and the location of a medical practice were estimated by binary logistic regression analysis. Via univariate evaluations the number of students who reported an increase in knowledge in different areas of competence as a result of the KAM was counted. Correlations between the intention to remain in the KAM and the quality of teaching were evaluated on the basis of bivariate correlations. Results: 48% of the students agreed partly or fully that the KAM seminars enhanced their specialist competence. This individual acquiring of competence in the model project represented a significant predictor for the preferred choice of the area (OR 7.98; 95% CI [1.27-50.27], p=0.027. Students who assessed the commitment (r=0.504, support (r=0.526 and interaction management (r=0.529 of the mentors positively were more likely inclined to continue their

  9. Pilot phase evaluation of the elective general practice class: results of student surveys of the first two years.

    Science.gov (United States)

    Samos, Franziska-Antonia; Heise, Marcus; Fuchs, Stephan; Mittmann, Susanne; Bauer, Alexander; Klement, Andreas

    2017-01-01

    Background: Primary health care in rural regions is currently undergoing a global crisis in respect of the next generation of practitioners. National and international recommendations advise placing greater emphasis upon practical skills and competences in medical studies. It is also in the interest of training the next generation to include mentoring and longitudinal integration of contact to teaching practices for general medicine in an early stage. Consequently, the General Practice Class (KAM) was introduced in Halle in 2011 as an elective with 20 individually mentored students per year, beginning with the first subject-related semester. We are now reporting on the results of the evaluation for the first two years. Method: A standardised online survey was carried out with all students who took part in the KAM in the two years 2011 and 2012 (N=38). For both years the survey was made at the end of the first summer semester on the basis of an adapted version of the Heidelberger Inventar zur Lehrevaluation (Heidelberg Inventory for the Evaluation of Teaching, HILVE-II) and the Berliner Evaluationsinstrument für selbsteingeschätzte, studentische Kompetenzen (Berlin Evaluation Instrument for the self-assessment of student competences, BEvaKomp) . Furthermore, each year the preference for the choice of specialty and location of a medical practice was queried. Predictors for the preference of the chosen specialty and the location of a medical practice were estimated by binary logistic regression analysis. Via univariate evaluations the number of students who reported an increase in knowledge in different areas of competence as a result of the KAM was counted. Correlations between the intention to remain in the KAM and the quality of teaching were evaluated on the basis of bivariate correlations. Results: 48% of the students agreed partly or fully that the KAM seminars enhanced their specialist competence. This individual acquiring of competence in the model project

  10. Evaluation of the Effect of Fixation Angle between Polyaxial Pedicle Screw Head and Rod on the Failure of Screw-Rod Connection

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    Engin Çetin

    2015-01-01

    Full Text Available Introduction. Polyaxial screws had been only tested according to the ASTM standards (when they were perpendicularly positioned to the rod. In this study, effects of the pedicle screws angled fixation to the rod on the mechanical properties of fixation were investigated. Materials and Method. 30 vertically fixed screws and 30 screws fixed with angle were used in the study. Screws were used in three different diameters which were 6.5 mm, 7.0 mm, and 7.5 mm, in equal numbers. Axial pull-out and flexion moment tests were performed. Test results compared with each other using appropriate statistical methods. Results. In pull-out test, vertically fixed screws, in 6.5 mm and 7.0 mm diameter, had significantly higher maximum load values than angled fixed screws with the same diameters (P<0.01. Additionally, vertically fixed screws, in all diameters, had significantly greater stiffness according to corresponding size fixed with angle (P<0.005. Conclusion. Fixing the pedicle screw to the rod with angle significantly decreased the pull-out stiffness in all diameters. Similarly, pedicle screw instrumentation fixed with angle decreased the minimum sagittal angle between the rod and the screw in all diameters for flexion moment test but the differences were not significant.

  11. In situ exposure of herring embryos in Prince William Sound two years after the Exxon Valdez oil spill

    International Nuclear Information System (INIS)

    Kocan, R.; Brown, E.; Baker, T.

    1995-01-01

    In order to evaluate long-term residual toxicity, artificially spawned Pacific herring (Clupea pallasl) embryos were deployed at 5 oiled and 5 unoiled sites in Prince William Sound two years after the Exxon Valdez oil spill. Embryos were exposed at 1.5 m and 4.5 m below mean low water for 8--10 d post fertilization. The embryos were then retrieved and transported to the laboratory for hatching and evaluation under controlled conditions, Endpoints were (1) embryo survival, (2) live hatch, (3) deformed larvae and (4) larval dry weight. The oiled sites produced significantly (P < 0.01) more deformed larvae (63.3%) than did the unoiled sites (51.3%), but there was a lower hatching success at the unoiled sites which resulted in no overall difference in normal live larvae produced between oiled and unoiled sites. The mean dry weight of newly hatched larvae from the oiled sites (78 microg/larva) was significantly lower than those from the unoiled sites (97 microg/larva) at all depths (P < 0.01). Increased larval deformities and reduced hatching weight is consistent with what has been reported by several investigators for herring larvae experimentally and naturally exposed to petroleum hydrocarbons. Based on the data, there appeared to be differences between the previously oiled and unoiled sites relative to herring development, but it is not clear whether this was due to residual oil effects or parental effects

  12. Effect of continued cannabis use on medication adherence in the first two years following onset of psychosis.

    Science.gov (United States)

    Schoeler, Tabea; Petros, Natalia; Di Forti, Marta; Klamerus, Ewa; Foglia, Enrico; Murray, Robin; Bhattacharyya, Sagnik

    2017-09-01

    Uncertainty exists whether the use of non-prescription psychoactive substances following onset of a first episode of psychosis (FEP), in particular cannabis use, affects medication adherence. Data from FEP patients (N=233) obtained through prospective assessments measured medication adherence and pattern of cannabis and other substance use in the first two years following onset of psychosis. Multiple logistic regression analyses were employed to compare the different substance use groups with regard to risk of medication non-adherence, while controlling for confounders. The proportion of non-adherent patients was higher in those who continued using high-potency forms of cannabis (skunk-like) following the onset (83%) when compared to never regular users (51%), corresponding to an Odds Ratio (OR) of 5.26[95% Confidence Interval (CI) 1.91-15.68]. No significant increases in risk were present in those who used cannabis more sporadically or used milder forms of cannabis (hash-like). Other substances did not make an independent contribution in this model, including cigarette use ([OR 0.88, 95% CI 0.41-1.89]), alcohol use ([OR 0.66, 95% CI 0.27-1.64]) or regular use of other illicit drugs ([OR 1.03, 95% CI 0.34-3.15]) following the onset. These results suggest that continued use of high-potency cannabis following the onset of psychosis may adversely affect medication adherence. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

  13. A HISTOPATHOLOGICAL STUDY OF NON-NEOPLASTIC AND NEOPLASTIC LESIONS OF KIDNEY FOR A PERIOD OF TWO YEARS

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    Jagadeeswari Suvvari

    2018-01-01

    Full Text Available BACKGROUND Nephrectomy is a common procedure in surgical practice. There are many indications for nephrectomy, non-neoplastic and neoplastic conditions. The common conditions being chronic pyelonephritis and renal tumours. A detailed and meticulous histopathological examination is essential to establish the diagnosis of lesions of kidney. MATERIALS AND METHODS It is a retrospective study for a period of two years from January 2015 to December 2016 at a tertiary care centre. 34 cases of nephrectomy specimens were analysed and data recorded. RESULTS Non-neoplastic lesions were constituting 47.05% (16 of cases and 52.94% (18 cases were neoplastic lesions. Lesions were more common in females with male:female ratio of 1:1.4. Both the lesions were common in age group of 41-50 years. CONCLUSION The prevalence of neoplastic lesions was more common than non-neoplastic lesions. The commonest indication for nephrectomy was chronic pyelonephritis followed by renal tumours. Histopathological examination in correlation with clinical and radiological features plays a great role in subcategorisation of lesions accurately to ensure better therapy.

  14. Update on excimer laser photorefractive keratectomy (PRK) at Cedars-Sinai Medical Center: two-year experience

    Science.gov (United States)

    Maguen, Ezra I.; Salz, James J.; Warren, Cathy; Papaioannou, Thanassis; Nesburn, Anthony B.; Macy, Jonathan I.; Hofbauer, John; Grundfest, Warren S.

    1993-06-01

    Our two year experience with excimer laser photorefractive keratectomy for the correction of myopia on 160 eyes of 128 patients is described. All eyes were treated with a VISX Twenty- Twenty excimer laser, with the following parameters: radiant exposure 160 mJ/cm2, frequency 5 Hz, ablation zone diameter 5.0 to 5.5 mm, and stromal ablation rate 0.18 to 0.33 (mu) /pulse. A suction fixation ring was used in all cases either with nitrogen flow (79 eyes) or without nitrogen flow (81 eyes) across the cornea. Follow-up ranged from one month (152 eyes) to 24 months (12 eyes). The results are stable between 3 and 24 months with less than 0.25 D change in the mean postoperative spherical equivalents. In eyes with a follow-up of 6 to 24 months, 77% to 100% were 20/40 or better uncorrected, and 84% to 92% were corrected to within +/- 1 D of emmetropia. Further follow-up is needed to assess the long term safety and efficacy of the procedure.

  15. Metabolic control in type 1 diabetes patients practicing combat sports: at least two-year follow-up study.

    Science.gov (United States)

    Benbenek-Klupa, Teresa; Matejko, Bartlomiej; Klupa, Tomasz

    2015-01-01

    It is well recognized that physical activity should be an integral part of the management of diabetes. It remains controversial, however, whether combat sports, often preferred by young individuals type 1 diabetes mellitus (T1DM), may be performed without high risk of metabolic decompensation. The aim of this observational study was to summarize a two-year follow-up period of five young male patients with T1DM practicing combat sports under the care of a physical-activity oriented specialist diabetes outpatient clinic. Of the five patients, three mixed martial arts and two kick-boxing competitors were included in the study. To control glucose in each patient, an individual approach was used that took into consideration the type of training, the sequence of the exercises, and the relative proportion of different forms of exercise. During the follow-up, glycemic control was improved and maintained in all individuals. Neither an episode of hospitalization-requiring diabetic ketoacidosis nor severe hypoglycemia occurred in these patients during the follow-up. In conclusion, an individual approach for T1DM patients practicing combat sports may result in achieving and maintaining satisfactory glycemic control without increased risk of metabolic decompensation.

  16. Two Years after Molecular Diagnosis of Familial Hypercholesterolemia: Majority on Cholesterol-Lowering Treatment but a Minority Reaches Treatment Goal

    Science.gov (United States)

    Huijgen, Roeland; Kindt, Iris; Verhoeven, Sjoerd B. J.; Sijbrands, Eric J. G.; Vissers, Maud N.; Kastelein, John J. P.; Hutten, Barbara A.

    2010-01-01

    Background The risk of premature cardiovascular disease in patients with familial hypercholesterolemia (FH) can be profoundly reduced by cholesterol-lowering therapy, and current guidelines for FH advocate ambitious low-density lipoprotein cholesterol (LDL-C) goals. In the present study, we determined whether these goals are reflected in current clinical practice once FH has been diagnosed. Methodology/Principal Findings In 2008, we sent questionnaires to all subjects (aged 18–65 years) who were molecularly diagnosed with FH in the year 2006 through the screening program in the Netherlands. Of these 1062 subjects, 781 completed the questionnaire (46% males; mean age: 42±12 years; mean LDL-C at molecular diagnosis (baseline): 4.1±1.3 mmol/L). The number of persons that used cholesterol-lowering therapy increased from 397 (51%) at baseline to 636 (81%) after diagnosis. Mean treated LDL-C levels decreased significantly to 3.2±1.1 mmol/L two years after diagnosis. Only 22% achieved the LDL-C target level of ≤2.5 mmol/L. Conclusions/Significance The proportion of patients using cholesterol-lowering medication was significantly increased after FH diagnosis through genetic cascade screening. The attained LDL-C levels were lower than those reported in previous surveys on medication use in FH, which could reflect the effect of more stringent lipid target levels. However, only a minority of the medication users reached the LDL-C target. PMID:20169164

  17. Maternal Factors as Moderators or Mediators of PTSD Symptoms in Very Young Children: A Two-Year Prospective Study.

    Science.gov (United States)

    Scheeringa, Michael S; Myers, Leann; Putnam, Frank W; Zeanah, Charles H

    2015-07-01

    Research has suggested that parenting behaviors and other parental factors impact the long-term outcome of children's posttraumatic stress disorder (PTSD) symptoms. In a sample of 62 children between the ages of one and six who experienced life-threatening traumas, PTSD was measured prospectively two years apart. Seven maternal factors were measured in a multi-method, multi-informant design. Both moderation and mediation models, with different theoretical and mechanism implications, were tested. Moderation models were not significant. Mediation models were significant when the mediator variable was maternal symptoms of PTSD or depression (measured at Time 1), self-report of maternal escape/avoidance coping (measured at Time 2), or self-report emotional sensitivity (measured at Time 2). Greater maternal emotional sensitivity was associated with greater Time 2 PTSD symptoms among children. Observational measures of emotional sensitivity as the mediator were not supported. Correlation of parents' and children's symptoms is a robust finding, however caution is warranted in attributing children's PTSD symptoms to insensitive parenting.

  18. Impact of 10-valent pneumococcal conjugate vaccine on pneumococcal meningitis in children up to two years of age in Brazil

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    Indianara Maria Grando

    2015-02-01

    Full Text Available The objective of this study was to analyze the impact of vaccination against Streptococcus pneumoniae on the morbidity and mortality from pneumococcal meningitis in children ≤ 2 years in Brazil, from 2007 to 2012. This is a descriptive study and ecological analysis using data from the Information System on Notifiable Diseases. Pre-vaccination (2007-2009 and post-vaccination (2011-2012 periods were defined to compare incidence rates and mortality. A total of 1,311 cases and 430 deaths were reported during the study period. Incidence decreased from 3.70/100,000 in 2007 to 1.84/100,000 in 2012, and mortality decreased from 1.30/100,000 to 0.40/100,000, or 50% and 69% respectively, with the greatest impact in the 6-11 month age group. This decrease in Pneumococcal meningitis morbidity and mortality rates two years after introduction of the 10-valent pneumococcal conjugate vaccine suggests its effectiveness.

  19. Protective immunity and lack of histopathological damage two years after DNA vaccination against infectious hematopoietic necrosis virus in trout

    Science.gov (United States)

    Kurath, Gael; Garver, Kyle A.; Corbeil, Serge; Elliott, Diane G.; Anderson, Eric D.; LaPatra, Scott E.

    2006-01-01

    The DNA vaccine pIHNw-G encodes the glycoprotein of the fish rhabdovirus infectious hematopoietic necrosis virus (IHNV). Vaccine performance in rainbow trout was measured 3, 6, 13, 24, and 25 months after vaccination. At three months all fish vaccinated with 0.1 μg pIHNw-G had detectable neutralizing antibody (NAb) and they were completely protected from lethal IHNV challenge with a relative percent survival (RPS) of 100% compared to control fish. Viral challenges at 6, 13, 24, and 25 months post-vaccination showed protection with RPS values of 47–69%, while NAb seroprevalence declined to undetectable levels. Passive transfer experiments with sera from fish after two years post-vaccination were inconsistent but significant protection was observed in some cases. The long-term duration of protection observed here defined a third temporal phase in the immune response to IHNV DNA vaccination, characterized by reduced but significant levels of protection, and decline or absence of detectable NAb titers. Examination of multiple tissues showed an absence of detectable long-term histopathological damage due to DNA vaccination.

  20. Two-year outcomes of the Early Risers prevention trial with formerly homeless families residing in supportive housing.

    Science.gov (United States)

    Gewirtz, Abigail H; DeGarmo, David S; Lee, Susanne; Morrell, Nicole; August, Gerald

    2015-04-01

    This article reports 2-year outcomes from a cluster randomized, controlled trial of the Early Risers (ER) program implemented as a selective preventive intervention in supportive housing settings for homeless families. Based on the goals of this comprehensive prevention program, we predicted that intervention participants receiving ER services would show improvement in parenting and child outcomes relative to families in treatment-as-usual sites. The sample included 270 children in 161 families, residing in 15 supportive housing sites; multimethod, multi-informant assessments conducted at baseline and yearly thereafter included parent and teacher report of child adjustment, parent report of parenting self-efficacy, and parent-child observations that yielded scores of effective parenting practices. Data were modeled in HLM7 (4-level model accounting for nesting of children within families and families within housing sites). Two years' postbaseline, intent-to-treat (ITT) analyses indicated that parents in the ER group showed significantly improved parenting self-efficacy, and parent report indicated significant reductions in ER group children's depression. No main effects of ITT were shown for observed parenting effectiveness. However, over time, average levels of parenting self-efficacy predicted observed effective parenting practices, and observed effective parenting practices predicted improvements in both teacher- and parent-report of child adjustment. This is the first study to our knowledge to demonstrate prevention effects of a program for homeless families residing in family supportive housing. (c) 2015 APA, all rights reserved).

  1. Response of Runoff and Sediment on Skid Trails of Varying Gradient and Traffic Intensity over a Two-Year Period

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    Meghdad Jourgholami

    2017-12-01

    Full Text Available Compacted soil has lower water infiltration and hydraulic conductivity, which contributes to increased runoff and erosion on slopes. The aim of the present study was to assess runoff and sediment on three skidding trail longitudinal gradients (15%, 25%, and 35% and different levels of machine traffic (low, medium, and high, over a two-year period following the impact in the Hyrcanian forest, Iran. The results show that trail gradient and traffic intensity have a significant effect on soil bulk density and total porosity on the skid trails. The average runoff amount varied significantly among trail gradients and ranged from 1.59 mm on the 15% trail gradient and 2.76 mm on the 25% trail gradient, to 4.76 mm on the 35% trail gradient in the low traffic intensity. Average sediment also increased significantly with increasing trail gradient. Average sediment was 0.01 kg m−2, 0.03 kg m−2, and 0.05 kg m−2 on the low traffic intensity in the first year for the 15%, 25%, and 35% trail gradients, respectively. The largest runoff and sediment occurred in the first year and stressed the need for applying forestry Best Management Practices such as the use of brush mats during harvesting operations, as well as the installation of water diversion structures or seeding immediately after initial soil compaction and disturbance, in order to protect the bare soil from heavy rainfall.

  2. Hormonal (Cortical-Gonadotropic Axis) and Physical Changes With Two Years Intense Exercise Training in Elite Young Soccer Players.

    Science.gov (United States)

    Hammami, Mohamed Ali; Ben Abderrahman, Abderraouf; Hackney, Anthony C; Kebsi, Wiem; Owen, Adam L; Nebigh, Amar; Racil, Ghazi; Tabka, Zouhair; Zouhal, Hassane

    2017-09-01

    Hammami, MA, Ben Abderrahman, A, Hackney, AC, Kebsi, W, Owen, AL, Nebigh, A, Racil, G, Tabka, Z, and Zouhal, H. Hormonal (cortical-gonadotropic axis) and physical changes with two years intense exercise training in elite young soccer players. J Strength Cond Res 31(9): 2388-2397, 2017-The aim of this study was to investigate the effects of 2 soccer-training seasons on physical fitness and hormone concentrations in elite youth soccer players. Twenty male elite soccer players (SP, age 14.5 ± 0.4 years) and 20 male control subjects (CS, age 14.3 ± 0.3 years) participated in the study. Anthropometric measurements, aerobic (Yo-Yo Intermittent Recovery Test Level 1 [YYIRT1]) and anaerobic soccer relevant performances (jump and sprint tests), blood testosterone (T), cortisol (C), sex hormone binding globulin (SHBG), and T/C ratio were assessed 5 times (from T0 to T4) during 2 competitive seasons. Significant differences from basal values (Δ) of T, SHBG, and C between SP and CS were observed (p soccer players group compared with controls. Our findings also show that the T concentrations and power performance outcomes co-vary positively over the 2 soccer seasons in soccer players.

  3. TVT-ABBREVO: efficacy and two years follow-up for the treatment of stress urinary incontinence.

    Science.gov (United States)

    Capobianco, G; Dessole, M; Lutzoni, R; Surico, D; Ambrosini, G; Dessole, S

    2014-01-01

    To assess the effectiveness of inside-out TVT-ABBREVO in the surgical treatment of female stress urinary incontinence (SUI) with mean two-year follow-up. Fifty-six women underwent surgery for moderate-severe SUI. The technology used was the TVT-ABBREVO inside-out. Each woman at 12 and 24 months underwent postoperative evaluation by means of urodynamics, Q-tip test, CST, transperineal ultrasonography, and administration of "King's Health Questionnaire" (KHQ). The mean age of the women was 57.03 +/- 11.1 years (range 42-75). Postoperative urodynamics (12 months follow-up) resulted to be normal in 43/56 patients (76.79%), in 10/56 (17.86%) cases resulted in a considerable improvement of the symptomatology, and only 1/56 (1.78%) case had de novo overactive bladder (OAB), in 2/56 (3.57%) symptomatology unchanged. After administration of the KHQ 43/56 cases (76.79%) had resolution of the symptomatology, 10/56 cases (17.86%) improvement of the symptomatology, and no change in 3/56 cases (5.36%). In the authors' experience, the TVT-ABBREVO resulted technically simple. The TVT-ABBREVO procedure provides high objective and subjective long-term efficacy, a clinically meaningful improvement in patient quality of life, and an excellent safety profile.

  4. A two years study on vectors of cutaneous Leishmaniasis. Evidence for sylvatic transmission cycle in the state of Campeche, Mexico.

    Science.gov (United States)

    Rebollar-Téllez, E A; Ramírez-Fraire, A; Andrade-Narvaez, F J

    1996-01-01

    Vectors of cutaneous leishmaniasis in the State of Campeche were studied in relation to the transmission cycle of Leishmania (Le.) mexicana. To determine how transmission of leishmaniasis occurs, we collected phlebotomine sand flies for two years. In the first year (October 1990 to November 1991) the collections were made with CDC light traps, Shannon traps and direct captures at natural shelters around the village (La Libertad. In the second year (February 1993 to January 1994) the catches were performed at 8 km southeast of La Libertad in the forest. Female sand flies were examined for Leishmania. During the first year, 347 sand flies of nine species were collected, most of which were Lutzomyia deleoni (61.3%). When all nine species were considered, more females than males were captured. Low densities of anthropophillic species of sand flies around the village indicated that sylvatic transmission was taking place. For the second year. 1484 sand flies of 16 species were caught. The most common were L. olmeca olmeca (21.7%), L. cruciata (19.2%) and L. ovallesi (14.1%). Similarly, more females were caught than males. Thirty-five females of five species were found infected with flagellates believed to be Leishmania sp. The highest infection rate was found in L. olmeca olmeca (7.1%) followed by L. cruciata (4.5%) and L. ovallesi (1.1%). These data plus other evidence on the epidemiology of human cases and results from reservoir studies are discussed in relation to the sylvatic transmission cycle.

  5. Saving on natural resources with SRO - desalination of industrial waste water for reuse at ESKOM Tutuka (two years operating experience)

    Energy Technology Data Exchange (ETDEWEB)

    Walt, Mike van der; Wessels, A.

    2001-07-01

    Natural resources are protected and saved with the new spiral reverse osmosis (SRO) plant at the Eskom Tutuka power station in the Mpumalanga province of South Africa. 7,000 m{sup 3}/day of saline underground mine water blended with 5,400 m{sup 3}/day of cooling water blowdown is pretreated and desalinated before the product water is returned to the cooling water circuit. Weir Envig designed, constructed, installed and commissioned the plant in phases between August 1998 and April 1999 with innovative use of existing infrastructure and phased removal of the live, ageing electrodialysis reversal plant. The plant performance during two years of operation is presented, which demonstrates that good pretreatment and cleaning system design allows SRO to produce consistent high-quality water from this difficult and varying feed. The result is a coal mine with no effluent problems, a new source of water for the power station and a treatment plant, which produces significantly better condenser cooling water and maintain zero liquid discharge. (orig.)

  6. Personalization of restrictions and recommendations for patients heated with I-131. Experience during two years (2000-2001)

    International Nuclear Information System (INIS)

    Rivas Ballarin, M. A.; Ruiz Manzano, P.; Hernandez Vitoria, A.; Lozano Flores, F.; Ortega Pardina, P.

    2002-01-01

    The aim of this study is to set criteria for discharging patients treated with I-131, bearing in mind their familiar, social and working status according to the new Spanish legislation on radiological protection and European Guides related to the subject. A mathematical development and a normal contact pattern are proposed to calculate the period of restriction Tcr on the behaviour of the patients, so that the dose to their family friends and colleagues, both in thyroid carcinoma and hyperthyroidism, is within the dose constraints established in the European Guide Radiation Protection following iodine-131 therapy (exposures due to auto-patient or discharged in-patients) published in 1998. This systems has been applied ruing the last two years in Hospital Clinico Universitario Lozano Blesa of Zaragoza where the mean dose rate at 1 meter was 16,6 μSv/h on the day of discharge, after being in hospital for about 48 hours. Some results obtained for the three types of treatment are presented. (Author)

  7. Growth monitoring in children with low and normal birth weight up to two years: A retrospective cohort study

    Directory of Open Access Journals (Sweden)

    Mina Danaei

    2016-09-01

    Full Text Available Objective: This study was conducted aimed to compare the growth indices in 2 years old children with a history of low birth weight with normal birth weight children.Methods: Current retrospective cohort study on all two-year children with low birth weight and three times the normal weight children covered by health centers of Kahnooj, was conducted in 2015. Cares at birth, 1, 2, 4, 6, 7, 9, 12, 15, 18 and 24 months of age were studied and, child growth indices (weight, height, head circumference, along with some demographic variables were studied. Information were entered SPSS version 20 and the analysis was performed.Results: There were significant differences in children's growth of both groups in all periods of care. Despite the same slope, growth pattern in children showed a significant difference. Young mother, girl sex of baby and preterm birth are predictor factors of low birth weight.Conclusion: Trends and growth patterns of weight, height and head circumference in underweight children have significant difference with normal children and, despite the same slope, these children can not compensate for the backwardness of its growth to the age of two. So you need to plot separate growth curves for these children and, possible preventive measures should be taken to prevent bearing underweight baby.

  8. Trace element and nutrient accumulation in sunflower plants two years after the Aznalcóllar mine spill.

    Science.gov (United States)

    Madejón, P; Murillo, J M; Marañón, T; Cabrera, F; Soriano, M A

    2003-05-20

    The failure of a tailing pond dam at the Aznalcóllar pyrite mine (SW Spain) in April 1998 released a toxic spill affecting approximately 4300 ha along the Agrio and Guadiamar valleys. Two years later, we have studied yield and concentration of mineral nutrients and trace elements in sunflower plants grown in the spill-affected soil, and in an adjacent unaffected soil as comparison. The study has been carried out in plants at seedling (V4) and mature (R8) stages. Shoot and root biomass of sunflower seedlings was significantly smaller in the affected soil than in the unaffected soil, but there was no significant difference at the mature stage. Oil production was greater in the spill-affected plants. We have not detected any 'fertilising' effect caused by the acid waters of the spill on the main nutrient (N, P and Ca) acquisition, as documented in 1998 for sunflower plants flooded by the spill. Sunflower plants growing in the spill-affected soil reached adequate levels of nutrients. None of the trace elements measured-As, Cd, Cu, Pb and Tl-reached levels either phytotoxic or toxic for humans or animals in seeds and the above-ground part of the spill-affected plants. We evaluate the potential use of sunflower plants for phytoremediation. The potential for phytoextraction is very low; however, it may be used for soil conservation. The production of oil (usable for industrial purposes) may add some value to this crop.

  9. A snapshot of genetic lineages of Mycobacterium tuberculosis in Ireland over a two-year period, 2010 and 2011.

    LENUS (Irish Health Repository)

    Fitzgibbon, M M

    2013-01-01

    Mycobacterial interspersed repetitive-unit-variable-number tandem repeat typing alone was used to investigate the genetic lineages among 361 Mycobacterium tuberculosis strains circulating in Ireland over a two-year period, 2010 and 2011. The majority of isolates, 63% (229\\/361), belonged to lineage 4 (Euro-American), while lineages 1 (Indo-Oceanic), 2 (East-Asian) and 3 (East-African–Indian) represented 12% of isolates each (42\\/361, 45\\/361, and 45\\/361, respectively). Sub-lineages Beijing (lineage 2), East-African–Indian (lineage 1) and Delhi\\/central-Asian (lineage 3) predominated among foreign-born cases, while a higher proportion of Euro-American lineages were identified among cases born in Ireland. Eighteen molecular clusters involving 63 tuberculosis (TB) cases were identified across four sub-lineages of lineage 4. While the mean cluster size was 3.5 TB cases, the largest cluster (involving 12 Irish-born cases) was identified in the Latin American–Mediterranean sub-lineage. Clustering of isolates was higher among Irish-born TB cases (47 of 63 clustered cases), whereas only one cluster (3\\/63) involved solely foreign-born individuals. Four multidrug-resistant cases identified during this period represented lineages 2 and 4. This study provides the first insight into the structure of the M. tuberculosis population in Ireland.

  10. Effects of salvage logging on soil properties and vegetation recovery in a fire-affected Mediterranean forest: A two year monitoring research.

    Science.gov (United States)

    García-Orenes, F; Arcenegui, V; Chrenková, K; Mataix-Solera, J; Moltó, J; Jara-Navarro, A B; Torres, M P

    2017-05-15

    Post-fire management can have an additional impact on the ecosystem; in some cases, even more severe than the fire. Salvage logging (SL) is a common practice in most fire-affected areas. The management of burnt wood can determine microclimatic conditions and seriously affect soil properties. In some cases, the way of doing it, using heavy machinery, and the vulnerability of soils to erosion and degradation can make this management potentially aggressive to soil. Research was done in "Sierra de Mariola Natural Park" (E Spain). A forest fire (>500ha) occurred in July 2012. In February 2013, SL treatment was applied in a part of the affected forest. Plots for monitoring this effect were installed in this area and in a similar nearby area where no treatment was done, used as control (C). Soil samplings were done immediately after treatment and every 6months during two years. Some soil properties were analysed, including organic matter (OM) content, nitrogen (N) available phosphorous (P) basal soil respiration (BSR), microbial biomass carbon (C mic ), bulk density (BD), water repellency (WR), aggregate stability (AS) and field capacity (FC). SL treatment caused an increase in BD, a decrease of AS, FC, OM and N. In the control area, in general the soil properties remained constant across the 2years of monitoring, and the microbial parameters (BSR and C mic ), initially affected by the fire, recovered faster in C than in the SL area. Plant recovery also showed some differences between treatments. No significant differences were observed in the number of plant species recorded (richness) comparing C versus SL plots, but the number of individuals of each species (evenness) was significantly higher in C plots. In conclusion, we can affirm that for the conditions of this study case, SL had a negative effect on the soil-plant system. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Part-Time Faculty Satisfaction at Two-Year Public Postsecondary Institutions: A Comparison of Involuntary Part-Time, Voluntary Part-Time, and Full-Time Faculty

    Science.gov (United States)

    Kinchen, Nancy Huval

    2010-01-01

    Part-time faculty members represent the majority of faculty at public two-year postsecondary institutions. Utilizing part-time faculty enables two-year institutions to control their instructional costs and maintain scheduling flexibility. However, part-time faculty are diverse in regards to their employment preference, some prefer part-time…

  12. Risk of future trauma based on alcohol screening scores: A two-year prospective cohort study among US veterans

    Science.gov (United States)

    2012-01-01

    Background Severe alcohol misuse as measured by the Alcohol Use Disorders Identification Test–Consumption (AUDIT-C) is associated with increased risk of future fractures and trauma-related hospitalizations. This study examined the association between AUDIT-C scores and two-year risk of any type of trauma among US Veterans Health Administration (VHA) patients and assessed whether risk varied by age or gender. Methods Outpatients (215, 924 male and 9168 female) who returned mailed AUDIT-C questionnaires were followed for 24 months in the medical record for any International Statistical Classification of Diseases and Related Health Problems (ICD-9) code related to trauma. The two-year prevalence of trauma was examined as a function of AUDIT-C scores, with low-level drinking (AUDIT-C 1–4) as the reference group. Men and women were examined separately, and age-stratified analyses were performed. Results Having an AUDIT-C score of 9–12 (indicating severe alcohol misuse) was associated with increased risk for trauma. Mean (SD) ages for men and women were 68.2 (11.5) and 57.2 (15.8), respectively. Age-stratified analyses showed that, for men ≤50 years, those with AUDIT-C scores ≥9 had an increased risk for trauma compared with those with AUDIT-C scores in the 1–4 range (adjusted prevalence, 25.7% versus 20.8%, respectively; OR = 1.24; 95% confidence interval [CI], 1.03–1.50). For men ≥65 years with average comorbidity and education, those with AUDIT-C scores of 5–8 (adjusted prevalence, 7.9% versus 7.4%; OR = 1.16; 95% CI, 1.02–1.31) and 9–12 (adjusted prevalence 11.1% versus 7.4%; OR = 1.68; 95% CI, 1.30–2.17) were at significantly increased risk for trauma compared with men ≥65 years in the reference group. Higher AUDIT-C scores were not associated with increased risk of trauma among women. Conclusions Men with severe alcohol misuse (AUDIT-C 9–12) demonstrate an increased risk of trauma. Men ≥65 showed an increased risk

  13. Molecular diagnostics for lassa fever at Irrua specialist teaching hospital, Nigeria: lessons learnt from two years of laboratory operation.

    Directory of Open Access Journals (Sweden)

    Danny A Asogun

    Full Text Available BACKGROUND: Lassa fever is a viral hemorrhagic fever endemic in West Africa. However, none of the hospitals in the endemic areas of Nigeria has the capacity to perform Lassa virus diagnostics. Case identification and management solely relies on non-specific clinical criteria. The Irrua Specialist Teaching Hospital (ISTH in the central senatorial district of Edo State struggled with this challenge for many years. METHODOLOGY/PRINCIPAL FINDINGS: A laboratory for molecular diagnosis of Lassa fever, complying with basic standards of diagnostic PCR facilities, was established at ISTH in 2008. During 2009 through 2010, samples of 1,650 suspected cases were processed, of which 198 (12% tested positive by Lassa virus RT-PCR. No remarkable demographic differences were observed between PCR-positive and negative patients. The case fatality rate for Lassa fever was 31%. Nearly two thirds of confirmed cases attended the emergency departments of ISTH. The time window for therapeutic intervention was extremely short, as 50% of the fatal cases died within 2 days of hospitalization--often before ribavirin treatment could be commenced. Fatal Lassa fever cases were older (p = 0.005, had lower body temperature (p<0.0001, and had higher creatinine (p<0.0001 and blood urea levels (p<0.0001 than survivors. Lassa fever incidence in the hospital followed a seasonal pattern with a peak between November and March. Lassa virus sequences obtained from the patients originating from Edo State formed--within lineage II--a separate clade that could be further subdivided into three clusters. CONCLUSIONS/SIGNIFICANCE: Lassa fever case management was improved at a tertiary health institution in Nigeria through establishment of a laboratory for routine diagnostics of Lassa virus. Data collected in two years of operation demonstrate that Lassa fever is a serious public health problem in Edo State and reveal new insights into the disease in hospitalized patients.

  14. Consistent codling moth population decline by two years of mating disruption in apple: a Flemish case study.

    Science.gov (United States)

    Bangels, E; Beliën, T

    2012-01-01

    Codling moth (Cydia pomonella) is one of the most important pests in apple and pear. In 2010 mating disruption became a key pest management tactic in Flemish pip fruit orchards, largely due to a government subsidy and demonstrating projects aiming to widen the area treated by pheromones as large as possible. As a consequence, the mating disruption strategy was applied at approximately 7.500 ha, or half of the pip fruit area, in 2010 and 2011. The sudden large-scale implementation of this technique changed the codling moth management landscape. Here we present a case study of a commercially managed orchard that suffered from high codling moth pressures for many years, as did the surrounding area. The RAK3 mating disruption system was introduced at this location in 2010, and was continued in 2011. Systematic detailed codling moth flight data for this location are available for many years. In addition, comprehensive data on damage levels of chemically untreated windows spread all over the test orchard in a randomized block design were obtained in successive years, enabling us to thoroughly evaluate the effect of the changed codling moth management strategy. Data from 2011 included damage levels in chemically treated windows when the entire orchard was applied once at the flight peak of Cydia pomonella. In 2009, before introduction of mating disruption, a mean of 8.25 +/- 5.54% of the fruits were infested at harvest when assessed in completely untreated windows. After two years of mating disruption, supported with a full chemical support in 2010, except for the untreated assessment windows, and only one application on the flight peak of 2011, damage was reduced to less than 0.03% at harvest. This is a valuable case study to demonstrate the benefits of the mating disruption approach.

  15. The Influence of Gestational Diabetes on Neurodevelopment of Children in the First Two Years of Life: A Prospective Study.

    Directory of Open Access Journals (Sweden)

    Shirong Cai

    Full Text Available Analyze the relation of gestational diabetes and maternal blood glucose levels to early cognitive functions in the first two years of life.In a prospective Singaporean birth cohort study, pregnant women were screened for gestational diabetes at 26-28 weeks gestation using a 75-g oral glucose tolerance test. Four hundred and seventy three children (n = 74 and n = 399 born to mothers with and without gestational diabetes respectively underwent neurocognitive assessments at 6, 18, and/or 24 month, including electrophysiology during an attentional task and behavioral measures of attention, memory and cognition.Gestational diabetes is related to left hemisphere EPmax amplitude differences (oddball versus standard at both six (P = 0.039 and eighteen months (P = 0.039, with mean amplitudes suggesting offspring of mothers with gestational diabetes exhibit greater neuronal activity to standard stimuli and less to oddball stimuli. Associations between 2-hour maternal glucose levels and the difference in EPmax amplitude were marginal at 6 months [adjusted β = -0.19 (95% CI: -0.42 to +0.04 μV, P = 0.100] and significant at 18 months [adjusted β = -0.27 (95% CI: -0.49 to -0.06 μV, P = 0.014], and the EPmax amplitude difference (oddball-standard associated with the Bayley Scales of Infant and toddler Development-III cognitive score at 24 months [β = 0.598 (95% CI: 0.158 to 1.038, P = 0.008].Gestational diabetes and maternal blood glucose levels are associated with offspring neuronal activity during an attentional task at both six and eighteen months. Such electrophysiological differences are likely functionally important, having been previously linked to attention problems later in life.

  16. Reflections on two years after establishing an orthogeriatric unit: a focus group study of healthcare professionals' expectations and experiences.

    Science.gov (United States)

    Abrahamsen, C; Nørgaard, B; Draborg, E; Nielsen, D

    2017-08-25

    For decades hospitals have been "vertically" organized, with the risk that specialization leads to fragmented and one-sided views of patient care and treatment that may cause poor communication and coordination of care and treatment. Two years after the introduction of an orthogeriatric unit for elderly patients admitted with fragility fractures, we studied the involved healthcare professionals' perspectives and experiences with working in an interprofessional organization. We performed four focus groups interviews with 19 healthcare workers representing different professions. The interviews were analysed using systematic text condensation (STC). Three themes were identified: 1) A patient-centred approach, 2) An opportunity for professional growth and 3) The benefits of interprofessional collaboration. The interviewees emphasized in particular the systematic and frequent face-to-face communication enabled by the interprofessional team meetings as essential to their feeling of enhanced collegial solidarity. All groups expressed their respect for other groups' competences and their vital contributions to good orthogeriatric care. However, collaboration was challenged by the groups' divergent views of the patients and of the relevance of the information given in the weekly meetings. Heavy workloads were also mentioned. The opportunity for professional growth was also felt to be imperilled by some professionals. All participants indicated their view that the orthogeriatric organization had improved the quality of care and treatment. Furthermore, good communication, mutual respect for other professional competences and shared goals were found to have enhanced interprofessional collaboration and improved the sense of having a shared mission. However, differences in approaches and expectations continued to challenge the orthogeriatric model after 2 years. Neither did all professionals find orthogeriatric care professionally challenging.

  17. The Impact of Prediabetes on Two-Year Clinical Outcomes in Patients Undergoing Elective Percutaneous Coronary Intervention.

    Science.gov (United States)

    Choi, Woong Gil; Rha, Seung Woon; Choi, Byoung Geol; Choi, Se Yeon; Byun, Jae Kyeong; Mashaly, Ahmed; Park, Yoonjee; Jang, Won Young; Kim, Woohyeun; Choi, Jah Yeon; Park, Eun Jin; Na, Jin Oh; Choi, Cheol Ung; Kim, Eung Ju; Park, Chang Gyu; Seo, Hong Seog

    2018-06-01

    Prediabetes is an independent risk factor for cardiovascular disease. However, data on the long term adverse clinical outcomes of prediabetic patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) are scarce. The study population comprised 674 consecutive non-diabetic patients who underwent elective PCI between April 2007 and November 2010. Prediabetes was defined as hemoglobin A1c (HbA1c) of 5.7% to 6.4%. Two-year cumulative clinical outcomes of prediabetic patients (HbA1c of 5.7% to 6.4%, n=242) were compared with those of a normoglycemic group (prediabetes group. There was no significant difference between the two groups in coronary angiographic parameters, except for a higher incidence of diffuse long lesion in the prediabetes group. For prediabetic patients, trends toward higher incidences of binary restenosis (15.6% vs. 9.8 %, p=0.066) and late loss (0.71±0.70 mm vs. 0.59±0.62 mm, p=0.076) were noted. During the 24 months of follow up, the incidence of mortality in prediabetic patients was higher than that in normoglycemic patients (5.5% vs. 1.5%, p=0.007). In our study, a higher death rate and a trend toward a higher incidence of restenosis in patients with prediabetes up to 2 years, compared to those in normoglycemic patients, undergoing elective PCI with contemporary DESs. © Copyright: Yonsei University College of Medicine 2018.

  18. Nutritional advice in older patients at risk of malnutrition during treatment for chemotherapy: a two-year randomized controlled trial.

    Science.gov (United States)

    Bourdel-Marchasson, Isabelle; Blanc-Bisson, Christelle; Doussau, Adélaïde; Germain, Christine; Blanc, Jean-Frédéric; Dauba, Jérôme; Lahmar, Cyril; Terrebonne, Eric; Lecaille, Cédric; Ceccaldi, Joël; Cany, Laurent; Lavau-Denes, Sandrine; Houede, Nadine; Chomy, François; Durrieu, Jessica; Soubeyran, Pierre; Senesse, Pierre; Chene, Geneviève; Fonck, Mariane

    2014-01-01

    We tested the effect of dietary advice dedicated to increase intake in older patients at risk for malnutrition during chemotherapy, versus usual care, on one-year mortality. We conducted a multicentre, open-label interventional, stratified (centre), parallel randomised controlled trial, with a 1∶1 ratio, with two-year follow-up. Patients were aged 70 years or older treated with chemotherapy for solid tumour and at risk of malnutrition (MNA, Mini Nutritional Assessment 17-23.5). Intervention consisted of diet counselling with the aim of achieving an energy intake of 30 kCal/kg body weight/d and 1.2 g protein/kg/d, by face-to-face discussion targeting the main nutritional symptoms, compared to usual care. Interviews were performed 6 times during the chemotherapy sessions for 3 to 6 months. The primary endpoint was 1-year mortality and secondary endpoints were 2-year mortality, toxicities and chemotherapy outcomes. Between April 2007 and March 2010 we randomised 341 patients and 336 were analysed: mean (standard deviation) age of 78.0 y (4·9), 51.2% male, mean MNA 20.2 (2.1). Distribution of cancer types was similar in the two groups; the most frequent were colon (22.4%), lymphoma (14.9%), lung (10.4%), and pancreas (17.0%). Both groups increased their dietary intake, but to a larger extent with intervention (pnutritional status changes was found. Response to chemotherapy was also similar between the groups. Early dietary counselling was efficient in increasing intake but had no beneficial effect on mortality or secondary outcomes. Cancer cachexia antianabolism may explain this lack of effect. ClinicalTrials.gov NCT00459589.

  19. Comparison in outcomes at two-years of age of very preterm infants born in 2000, 2005 and 2010.

    Directory of Open Access Journals (Sweden)

    Lénaïg Abily-Donval

    Full Text Available To investigate alteration in 2-year neurological/behavioral outcomes of very preterm infants born in a French level three neonatal intensive care unit.We conducted a prospective, comparative study of very preterm infants born before 33 weeks' gestation at 5-year intervals in 2000, 2005 and 2010 at Rouen University Hospital. Neonatal mortality/morbidities, ante- and neonatal treatments, and at age 2 years motor, cognitive and behavioral data were collected by standardized questionnaires.We included 536 very preterm infants. Follow-up rates at two years old were 78% in 2000, 93% in 2005 and 92% in 2010 respectively. No difference in gestational age, birthweight, neonatal mortality/morbidities was observed except a decrease in low grade subependymal/intraventricular hemorrhages. Care modifications concerned use of antenatal magnesium sulfate, breast-feeding and post-natal corticosteroid therapy. Significant improvement in motor outcome and dramatic decrease in cerebral palsy rates (12% in 2000, 6% in 2005, 1% in 2010, p<0.001 were observed, as were improvements in feeding behavior. Although a non significant difference to better psychosocial behavior was reported, there was no difference in cognitive outcome.Improvement in neuromotor outcome and behavior was reported. This could be due to multiple modifications in care: including administration of magnesium sulfate to women at risk of preterm birth, increase in breast-feeding, decrease in low grade subependymal/intraventricular hemorrhages, and decrease in post-natal corticosteroid therapy, all of which require further investigation in other studies. Extended follow-up until school age is mandatory for better detection of cognitive, learning and behavioral disorders.

  20. The emergence of spanking among a representative sample of children under two years of age in North Carolina.

    Directory of Open Access Journals (Sweden)

    Adam J. Zolotor

    2011-06-01

    Full Text Available Spanking is common in the United States but less common in many European countries in which it has been outlawed. Being spanked has been associated with child abuse victimization, poor self-esteem, impaired parent-child relationships, and child and adult mental health, substance abuse, and behavioral consequences. Being spanked as a child has also been shown to increase the likelihood of abusing one’s own children or spouse as an adult. Spanking of very young children less than two is almost never recommended even among experts that consider spanking as reasonable in some circumstances. Using a cross-sectional anonymous telephone survey, we describe spanking rates among a representative sample of North Carolina mothers of children less than two years old and the association of spanking with demographic characteristics.A substantial proportion of mothers admit to spanking their very young children. The rate of spanking in the last year among all maternal respondents was 30%. Over 5% of the mothers of three month olds reported spanking. Over 70% of the mothers of 23 month olds reported spanking. Increased spanking was associated with higher age of the child and lower maternal age. With every month of age, a child had 27% increased odds of being spanked. Early spanking has been shown to be associated with poor cognitive development in early childhood. Further, early trauma has been shown to have significant effects on the early developing brain. It is therefore critical that health and human services professionals addres the risk of corporal punishment as a method of discipline early in the life of the child. The spanking of very young children may be an appropriate locus for policy and legislative debates regarding corporal punishment.

  1. Patients with chronic hepatitis type C and interferon-alpha-induced hyperthyroidism in two-years clinical follow-up.

    Science.gov (United States)

    Czarnywojtek, Agata; Zgorzalewicz-Stachowiak, Magorzata; Wasko, Ryszard; Czepczynski, Rafal; Szczepanek-Parulska, Ewelina; Waligorska-Stachura, Joanna; Kurdybacha, Peter; Bereszynska, Iwona; Florek, Ewa; Stangierski, Adam; Zdanowska, Joanna; Nikisch, Elżbieta; Sowinski, Jerzy; Ruchala, Marek

    2013-01-01

    Interferon-α (IFN-α) is a gold standard in the therapy of viral chronic hepatitis type C (CHC). However, such treatment might lead to thyroid dysfunction. Patients usually present hypothyroidism, but rarely also hyperthyroidism may develop. The aim of the study is to present two-year clinical follow-up of patients with CHC and IFN-α-induced hyperthyroidism (IIH), with special regard to the methods and efficacy of the therapy. A group of 106 patients with CHC and IIH were analyzed. Subjects were divided into two groups according to etiology: group 1, with Graves' disease (GD) and group 2, with Hashitoxicosis (HT). The diagnosis of GD and HT was based on: clinical signs of hyperthyroidism, hormonal profile (TSH, fT4, fT3), level of thyroid autoantibodies (Tg-Abs, TPO-Abs, TSHRAbs). Treatment of hyperthyroidism was monitored by repeated clinical assessment and laboratory tests. RESULST: 28 patients (26 with GD of which 5 exhibited mild orbitopathy and 2 with HT) were treated with radioiodine [the average dose of was 17 mCi [668 MBq]. In adition 78 out of 80 patients with HT mostly β-blocker therapy was successful (transient hyperthyroidism). At the end of the observation period, in group 1 remission was achieved in 17 (65.4%) cases, 6 (23.1%) patients showed hypothyroidism and 3 (11.5%) presented recurrence of hyperthyroidism. Most patients with IIH present Hashitoxicosis, while a minority of them develop Graves' disease. In a majority of patients with HT spontaneous remission of disease occurs. In patients with long-term hyperthyroidism, radioiodine therapy is an effective and well-tolerated.

  2. A two years study on vectors of cutaneous leishmaniasis: Evidence for sylvatic transmission cycle in the State of Campeche, Mexico

    Directory of Open Access Journals (Sweden)

    Eduardo A Rebollar-Téllez

    1996-10-01

    Full Text Available Vectors of cutaneous leishmaniasis in the State of Campeche were studied in relation to the transmission cycle of Leishmania (Le. mexicana. To determine how transmission of leishmaniasis occurs, we collected phlebotomine sand flies for two years. In the first year (October 1990 to November 1991 the collections were made with CDC light traps, Shannon traps and direct captures at natural shelters around the village (<200 m of La Libertad. In the second year (February 1993 to January 1994 the catches were performed at 8 km southeast of La Libertad in the forest. Female sand flies were examined for Leishmania. During the first year, 347 sand flies of nine species were collected, most of which were Lutzomyia deleoni (61.3%. When all nine species were considered, more females than males were captured. Low densities of anthropophillic species of sand flies around the village indicated that sylvatic transmission was taking place. For the second year, 1484 sand flies of 16 species were caught. The most common were L. olmeca olmeca (21.7%, L. cruciata (19.2% and L. ovallesi (14.1%. Similarly, more females were caught than males. Thirty-five females of five species were found infected with flagellates believed to be Leishmania sp. The highest infection rate was found in L. olmeca olmeca (7.1% followed by L. cruciata (4.5% and L. ovallesi (1.1%. These data plus other evidence on the epidemiology of human cases and results from reservoir studies are discussed in relation to the sylvatic transmission cycle.

  3. Change and associated factors of self-esteem among children in rural China: A two-year longitudinal study.

    Science.gov (United States)

    Wu, Yi-Le; Chen, Jian; Yang, Lin-Sheng; Ding, Xiu-Xiu; Yang, Hui-Yun; Sun, Ye-Huan

    2015-01-01

    Childhood has been targeted as an especially important period for self-esteem formation. The aim of this study is to examine the change and associated factors of self-esteem among children in rural China. A two-year longitudinal study was conducted with a general elementary and secondary school population in Anhui Province, China including 816 children aged between 7 and 16 years. Generalized estimating equation (GEE) was used to examine relationships between low self-esteem and socio-demographic, family environment, and psychosocial factors. On average, self-esteem level among children was increased across three assessments. Multivariable analysis (GEE) showed that low self-esteem in children was clearly associated with male gender (OR = 1.45, 95%CI = 1.12-1.89), moderate and severe family dysfunction (OR = 1.88, 95%CI = 1.40-2.51; OR = 1.88, 95%CI = 1.25-2.83, respectively), quality of life (OR = .97, 95%CI = .96-.98), depression (OR = 1.89, 95%CI = 1.32-2.70), anxiety (OR = 2.05, 95%CI = 1.51-2.77), positive coping styles (OR = .91, 95%CI = .89-.94), and negative coping styles (OR = 1.05, 95%CI = 1.03-1.07). Self-esteem is a dynamic rather than a static construct during childhood. Low self-esteem among children was associated with a number of socio-demographic, family environment, and psychosocial factors. Further studies exploring the pathways and mechanisms by which the effect of these factors impact on self-esteem among children are warranted.

  4. The Ages and Stages Questionnaire and Neurodevelopmental Impairment in Two-Year-Old Preterm-Born Children.

    Directory of Open Access Journals (Sweden)

    Jorien M Kerstjens

    Full Text Available To test the ability of the Ages and Stages Questionnaire, Third Edition (ASQ3 to help identify or exclude neurodevelopmental impairment (NDI in very preterm-born children at the corrected age of two.We studied the test results of 224 children, born at <32 postmenstrual weeks, who had scores on ASQ3 and Bayley Scales of Infant and Toddler Development, Third Edition (BSIDIII and neurological examination at 22-26 months' corrected age. We defined NDI as a score of <70 on the cognitive--or motor composite scale of BSIDIII, or impairment on neurological examination or audiovisual screening. We compared NDI with abnormal ASQ3 scores, i.e., < -2SDs on any domain, and with ASQ3 total scores. To correct for possible overestimation of BSIDIII, we also analyzed the adjusted BSIDIII thresholds for NDI, i.e., scores <80 and <85.We found 61 (27% children with abnormal ASQ3 scores, and 10 (4.5% children who had NDI with original BSIDIII thresholds (<70. Twelve children had NDI at BSIDIII thresholds at <80, and 15 had <85. None of the 163 (73% children who passed ASQ3 had NDI. The sensitivity of ASQ3 to detect NDI was excellent (100%, its specificity was acceptable (76%, and its negative predictive value (NPV was 100%. Sensitivity and NPV remained high with the adjusted BSIDIII thresholds.The Ages and Stages Questionnaire is a simple, valid and cost-effective screening tool to help identify and exclude NDI in very preterm-born children at the corrected age of two years.

  5. Evaluation of percutaneous kidney biopsy complications in ambulatory patients- a two year review from a tertiary care centre

    International Nuclear Information System (INIS)

    Mansoor, K.; Azam, N.; Hashim, R.

    2016-01-01

    Objective: To evaluate the complications of percutaneous kidney biopsy in ambulatory patients in a tertiary care centre over a two year period. Study Design: Cross sectional, descriptive. Place and Duration of Study: The study was carried out at the Department of Nephrology Military Hospital, Rawalpindi from Jan 2008 to Jan 2010. Material and Methods: Patients referred to the Nephrology Department for kidney biopsy were considered for inclusion in the study provided they did not have any contraindications to the procedure and had a normotensive state with BP <130/90 mm Hg and a normal coagulation profile including partial thromboplastin time, prothrombin time, bleeding time and platelet count. Patients with an evidence of malignancy, congenital anomalies of kidneys on ultrasound examination or a skin disorder affecting the likely site of biopsy were excluded. Results: A total of 100 patients who merited standard indications for kidney biopsy were included in the study. Average age was 45.53 years (+1 SD = 10.96) with age range of 25 years to 75 years. There were 83 males (83 percent) and 17 females (17 percent) with male to female ratio of 4.9:1. Microscopic hematuria occurred in 82 (82 percent) patients. Gross hematuria occurred in 12 (12 percent) patients. Decrease in hemoglobin level by 1 g/dL or more occurred in 35 (35 percent). There was no episode of hypotension secondary to severe bleeding. No patient required transfusion. Surgery was not required in any patient for controlling bleeding. Death was not recorded among the reported complications. Conclusion: Percutaneous kidney biopsy can be safely conducted as an outpatient procedure with an observation time of 12 hours post-biopsy to watch for any complications. (author)

  6. The SPEAR3 Vacuum System - An Analysis of the First Two Years of Operation (2004 and 2005)

    International Nuclear Information System (INIS)

    Armenta, R.

    2005-01-01

    SPEAR 3, a synchrotron radiation source at the Stanford Linear Accelerator Center, has been in operation for the past two years. SPEAR 3 was designed to achieve high beam lifetimes while operating at a higher current level than previously achieved with SPEAR 2. Maintaining high electron beam lifetimes within the ring allows users to perform their experiments with a consistent supply of high current synchrotron radiation. The purpose of this analysis is to evaluate the SPEAR 3 vacuum system's performance during the 2004 and 2005 runs while considering methods to optimize and improve vacuum system conditioning, especially within the pumping system, so that a recommended plan of action can be created for the FY 2006 run. Monitoring the dynamics of the electron beam within the ring can be a difficult task. Pressure data obtained from the gages attached to pumps, temperature data obtained from thermocouples located at various locations around the ring, and beam lifetime projections help to provide some indication of the health of the electron beam, but the true conditions within the beam chamber can only be extrapolated. Data collected from sensors (gauges, thermocouples, etc.) located around the ring can be viewed and extracted from a program created at the Stanford Synchrotron Radiation Laboratory (SSRL) called Historyplot. Manipulation and analysis of data was performed with the commercially available programs Matlab and Excel. The data showed that the beam lifetimes in 2005 were much greater than they were in 2004, but it did not provide a clear indication as to why this occurred. One variable of major importance between the 2004 and 2005 runs is the Titanium Sublimation Pump (TSP) flash frequency (flashing is the process in which Titanium from filaments within the pump is sublimated onto the wall surfaces of the pump, where it removes gas molecules from the system by chemisorption). The data indicated that pressures in 2005 could have been lower, based on a

  7. Nutritional advice in older patients at risk of malnutrition during treatment for chemotherapy: a two-year randomized controlled trial.

    Directory of Open Access Journals (Sweden)

    Isabelle Bourdel-Marchasson

    Full Text Available We tested the effect of dietary advice dedicated to increase intake in older patients at risk for malnutrition during chemotherapy, versus usual care, on one-year mortality.We conducted a multicentre, open-label interventional, stratified (centre, parallel randomised controlled trial, with a 1∶1 ratio, with two-year follow-up. Patients were aged 70 years or older treated with chemotherapy for solid tumour and at risk of malnutrition (MNA, Mini Nutritional Assessment 17-23.5. Intervention consisted of diet counselling with the aim of achieving an energy intake of 30 kCal/kg body weight/d and 1.2 g protein/kg/d, by face-to-face discussion targeting the main nutritional symptoms, compared to usual care. Interviews were performed 6 times during the chemotherapy sessions for 3 to 6 months. The primary endpoint was 1-year mortality and secondary endpoints were 2-year mortality, toxicities and chemotherapy outcomes.Between April 2007 and March 2010 we randomised 341 patients and 336 were analysed: mean (standard deviation age of 78.0 y (4·9, 51.2% male, mean MNA 20.2 (2.1. Distribution of cancer types was similar in the two groups; the most frequent were colon (22.4%, lymphoma (14.9%, lung (10.4%, and pancreas (17.0%. Both groups increased their dietary intake, but to a larger extent with intervention (p<0.01. At the second visit, the energy target was achieved in 57 (40.4% patients and the protein target in 66 (46.8% with the intervention compared respectively to 13 (13.5% and 20 (20.8% in the controls. Death occurred during the first year in 143 patients (42.56%, without difference according to the intervention (p = 0.79. No difference in nutritional status changes was found. Response to chemotherapy was also similar between the groups.Early dietary counselling was efficient in increasing intake but had no beneficial effect on mortality or secondary outcomes. Cancer cachexia antianabolism may explain this lack of effect.ClinicalTrials.gov NCT

  8. Nutritional Advice in Older Patients at Risk of Malnutrition during Treatment for Chemotherapy: A Two-Year Randomized Controlled Trial

    Science.gov (United States)

    Bourdel-Marchasson, Isabelle; Blanc-Bisson, Christelle; Doussau, Adélaïde; Germain, Christine; Blanc, Jean-Frédéric; Dauba, Jérôme; Lahmar, Cyril; Terrebonne, Eric; Lecaille, Cédric; Ceccaldi, Joël; Cany, Laurent; Lavau-Denes, Sandrine; Houede, Nadine; Chomy, François; Durrieu, Jessica; Soubeyran, Pierre; Senesse, Pierre; Chene, Geneviève; Fonck, Mariane

    2014-01-01

    Objective We tested the effect of dietary advice dedicated to increase intake in older patients at risk for malnutrition during chemotherapy, versus usual care, on one-year mortality. Method We conducted a multicentre, open-label interventional, stratified (centre), parallel randomised controlled trial, with a 1∶1 ratio, with two-year follow-up. Patients were aged 70 years or older treated with chemotherapy for solid tumour and at risk of malnutrition (MNA, Mini Nutritional Assessment 17–23.5). Intervention consisted of diet counselling with the aim of achieving an energy intake of 30 kCal/kg body weight/d and 1.2 g protein/kg/d, by face-to-face discussion targeting the main nutritional symptoms, compared to usual care. Interviews were performed 6 times during the chemotherapy sessions for 3 to 6 months. The primary endpoint was 1-year mortality and secondary endpoints were 2-year mortality, toxicities and chemotherapy outcomes. Results Between April 2007 and March 2010 we randomised 341 patients and 336 were analysed: mean (standard deviation) age of 78.0 y (4·9), 51.2% male, mean MNA 20.2 (2.1). Distribution of cancer types was similar in the two groups; the most frequent were colon (22.4%), lymphoma (14.9%), lung (10.4%), and pancreas (17.0%). Both groups increased their dietary intake, but to a larger extent with intervention (p<0.01). At the second visit, the energy target was achieved in 57 (40.4%) patients and the protein target in 66 (46.8%) with the intervention compared respectively to 13 (13.5%) and 20 (20.8%) in the controls. Death occurred during the first year in 143 patients (42.56%), without difference according to the intervention (p = 0.79). No difference in nutritional status changes was found. Response to chemotherapy was also similar between the groups. Conclusion Early dietary counselling was efficient in increasing intake but had no beneficial effect on mortality or secondary outcomes. Cancer cachexia antianabolism may explain this

  9. A two-year's results of iontophoresis-assisted transepithelial corneal cross-linking for progressive keratoconus

    Directory of Open Access Journals (Sweden)

    Hong-Zhen Jia

    2016-07-01

    Full Text Available AIM: To report a two-year's results of iontophoresis-assisted transepithelial corneal cross-linking(I-CXLfor progressive keratoconus. METHODS: Thirty-four eyes in 24 patients with progressive keratoconus(mean age 21.0±5.6 years; range: 14-32 yearswere treated. After 1g/L riboflavin-distilled water solution was administered by iontophoresis-assited(current 1mAtransepithelial method for 5min in total, standard surface UVA irradiation(370nm, 3mW/cm2was performed at a 1-cm distance for 30min. The best corrected visual acuity(BCVAmeasured as LogMAR number, corneal refractive astigmatism, K1, K2, Kmean, Kmax, intraocular pressure, endothelial cell density, the thickness at corneal apex and the thinnest point were measured preoperatively and 2a postoperatively. RESULTS:At 2a after the procedure, BCVA(LogMARimproved from 0.32±0.25 to 0.25±0.19(t=2.849, P=0.015. K1 decreased from 47.12±4.33 to 46.06±4.77(t=2.652, P=0.015. K2 decreased from 51.36±5.59 to 50.40±6.16(t=2.121, P=0.047. Kmean decreased from 49.12±4.76 to 48.10±5.25(t=2.663, P=0.015. Kmax decreased from 57.57±8.30 to 55.91±8.14(t=2.398, P=0.026. The corneal apex thickness decreased from 476.90±38.71μm to 454.43±40.86μm(t=2.853, P=0.010. The thinnest thickness decreased from 464.38±39.92μm to 433.86±50.78μm(t=3.485, P=0.002. Corneal refractive astigmatism, intraocular pressure and endothelial cell density did not show significant changes. CONCLUSION: I-CXL for progressive keratoconus is safe and effective which can prevent deterioration of progressive keratoconus within 2a, but further long-term studies are necessary still.

  10. High rates of pneumonia in children under two years of age in a South East Asian refugee population.

    Directory of Open Access Journals (Sweden)

    Claudia Turner

    Full Text Available There are an estimated 150 million episodes of childhood pneumonia per year, with 11-20 million hospital admissions and 1.575 million deaths. Refugee children are particularly vulnerable, with poorly defined pneumonia epidemiology.We followed a birth cohort of 955 refugee infants, born over a one-year period, until two years of age. Clinical and radiographic pneumonia were diagnosed according to WHO criteria. Detailed characteristics were collected to determine risk factors for clinical, radiological and multiple episodes of pneumonia. Investigations were taken during a pneumonia episode to help determine or to infer an aetiological diagnosis.The incidence of clinical pneumonia was 0.73 (95% CI 0.70-0.75 episodes per child year (/CY and of radiological primary endpoint pneumonia (PEP was 0.22/CY (95% CI 0.20-0.24. The incidence of pneumonia without severe signs was 0.50/CY (95% CI 0.48-0.53, severe pneumonia 0.15/CY (95% CI 0.13-0.17 and very severe pneumonia 0.06/CY (0.05-0.07. Virus was detected, from a nasopharyngeal aspirate, in 61.3% of episodes. A reduced volume of living space per person (IRR 0.99, 95% CI 0.99-1.0, p = 0.003 and young maternal age (IRR 1.59, 95% CI 1.12-2.27, p = 0.01 were risk factors for developing pneumonia. The risk of a child having >1 episode of pneumonia was increased by having a shorter distance to the next house (IRR 0.86, 95% CI 0.74-1.00, p = 0.04. Infants were at risk of having an episode of PEP if there was a shorter distance from stove to bed (IRR 0.89, 95% CI 0.80-0.99, p = 0.03. Raised CRP and neutrophil values were associated with PEP.There was a high incidence of pneumonia in young children in this SE Asian refugee population. Viral infections were important, however CXR and non-specific marker findings suggested that bacteria may be involved in up to a third of cases.

  11. Phytoplankton diversity in the Upper Paraná River floodplain during two years of drought (2000 and 2001

    Directory of Open Access Journals (Sweden)

    PAF. Borges

    Full Text Available Floodplain lakes and lotic environments of the High Paraná River floodplain present notable biodiversity, especially in relation to phytoplanktonic community. The goal of this work was to evaluate phytoplankton diversity (alpha, beta and gamma in three subsystems during two years of drought (2000 and 2001. We sampled 33 habitats at the pelagic zone subsurface during February and August. Due to low hydrometric levels of the Paraná and Ivinhema Rivers, there was no clear distinction between the potamophase and limnophase periods for the two hydrosedimentological cycles analysed. We recorded 366 taxa. The values obtained for gamma diversity estimators ranged from 55.5-87.8%. DCA and variance analyses revealed only spatial differences in the phytoplankton composition. The mean values of species richness, evenness and Shannon diversity were low, especially when compared to those obtained in previous periods for Baía subsystem. The highest mean values of species richness were verified in the connected floodplain lakes. The highest beta diversity was obtained from the Paraná subsystem and lotic environments in 2001. In general, we observed that the Upper Paraná River floodplain has the highest values of species richness, evenness and H' during the potamophase period, when the flood facilitates dispersion. However, this pattern was not observed in 2000 and 2001, years influenced by La Niña. Besides the low precipitation observed during that period, we must consider the influence of the Porto Primavera impoundment, which also altered the discharge regime of the Paraná River by decreasing the degree of connectivity between fluvial channels and the lentic environments of the floodplain. Thus, the prevalence of conditions characterising the limnophase during 2000 and 2001 explains the lack of significant variability registered for most components of phytoplankton diversity over the study period. We conclude that variations in phytoplankton diversity

  12. Evaluation of short-term tracer fluctuations in groundwater and soil air in a two year study

    Science.gov (United States)

    Jenner, Florian; Mayer, Simon; Aeschbach, Werner; Weissbach, Therese

    2016-04-01

    The application of gas tracers like noble gases (NGs), SF6 or CFCs in groundwater studies such as paleo temperature determination requires a detailed understanding of the dynamics of reactive and inert gases in the soil air with which the infiltrating water equilibrates. Due to microbial gas consumption and production, NG partial pressures in soil air can deviate from atmospheric air, an effect that could bias noble gas temperatures estimates if not taken into account. So far, such an impact on NG contents in groundwater has not been directly demonstrated. We provide the first long-term study of the above mentioned gas tracers and physical parameters in both the saturated and unsaturated soil zone, sampled continuously for more than two years near Mannheim (Germany). NG partial pressures in soil air correlate with soil moisture and the sum value of O2+CO2, with a maximal significant enhancement of 3-6% with respect to atmospheric air during summer time. Observed seasonal fluctuations result in a mass dependent fractionation of NGs in soil air. Concentrations of SF6 and CFCs in soil air are determined by corresponding fluctuations in local atmospheric air, caused by industrial emissions. Arising concentration peaks are damped with increasing soil depth. Shallow groundwater shows short-term NG fluctuations which are smoothed within a few meters below the water table. A correlation between NG contents of soil air and of groundwater is observable during strong recharge events. However, there is no evidence for a permanent influence of seasonal variations of soil air composition on shallow groundwater. Fluctuating NG contents in shallow groundwater are rather determined by variations of soil temperature and water table level. Our data gives evidence for a further temperature driven equilibration of groundwater with entrapped air bubbles within the topmost saturated zone, which permanently occurs even some years after recharge. Local subsurface temperature fluctuations

  13. Child Intelligence and Reductions in Water Arsenic and Manganese: A Two-Year Follow-up Study in Bangladesh.

    Science.gov (United States)

    Wasserman, Gail A; Liu, Xinhua; Parvez, Faruque; Factor-Litvak, Pam; Kline, Jennie; Siddique, Abu B; Shahriar, Hasan; Uddin, Mohammed Nasir; van Geen, Alexander; Mey, Jacob L; Balac, Olgica; Graziano, Joseph H

    2016-07-01

    , Siddique AB, Shahriar H, Uddin MN, van Geen A, Mey JL, Balac O, Graziano JH. 2016. Child intelligence and reductions in water arsenic and manganese: a two-year follow-up study in Bangladesh. Environ Health Perspect 124:1114-1120; http://dx.doi.org/10.1289/ehp.1509974.

  14. Lessons Learned from the First Two Years of Nature's Notebook, the USA National Phenology Network's Plant and Animal Observation Program

    Science.gov (United States)

    Crimmins, T. M.; Rosemartin, A.; Denny, E. G.; Weltzin, J. F.; Marsh, L.

    2010-12-01

    Nature’s Notebook is the USA National Phenology Network’s (USA-NPN) national-scale plant and animal phenology observation program. The program was launched in March 2009 focusing only on plants; 2010 saw the addition of animals and the name and identity “Nature’s Notebook.” Over these two years, we have learned much about how to effectively recruit, train, and retain participants. We have engaged several thousand participants and can report a retention rate, reflected in the number of registered individuals that report observations, of approximately 25%. In 2009, participants reported observations on 133 species of plants on an average of nine days of the year, resulting in over 151,000 records in the USA-NPN phenology database. Results for the 2010 growing season are still being reported. Some of our most valuable lessons learned have been gleaned from communications with our observers. Through an informal survey, participants indicated that they would like to see more regular and consistent communications from USA-NPN program staff; clear, concise, and readily available training materials; mechanisms to keep them engaged and continuing to participate; and quick turn-around on data summaries. We are using this feedback to shape our program into the future. Another key observation we’ve made about our program is the value of locally and regionally-based efforts to implement Nature’s Notebook; some of our most committed observers are participating through partner programs such as the University of California-Santa Barbara Phenology Stewardship Program, Arbor Day Foundation, and the Great Sunflower Project. Future plans include reaching out to more partner organizations and improving our support for locally-based implementations of the Nature’s Notebook program. We have also recognized that the means for reaching and retaining potential participants in Nature’s Notebook vary greatly across generations. As the majority of our participants to

  15. A two year (2008-2009) analysis of severe convective storms in the Mediterranean basin as observed by satellite imagery

    Science.gov (United States)

    Gozzini, B.; Melani, S.; Pasi, F.; Ortolani, A.

    2010-09-01

    The increasing damages caused by natural disasters, a great part of them being direct or indirect effects of severe convective storms (SCS), seem to suggest that extreme events occur with greater frequency, also as a consequence of climate changes. A better comprehension of the genesis and evolution of SCS is then necessary to clarify if and what is changing in these extreme events. The major reason to go through the mechanisms driving such events is given by the growing need to have timely and precise predictions of severe weather events, especially in areas that show to be more and more sensitive to their occurrence. When dealing with severe weather events, either from a researcher or an operational point of view, it is necessary to know precisely the conditions under which these events take place to upgrade conceptual models or theories, and consequently to improve the quality of forecasts as well as to establish effective warning decision procedures. The Mediterranean basin is, in general terms, a sea of small areal extent, characterised by the presence of several islands; thus, a severe convection phenomenon originating over the sea, that lasts several hours, is very likely to make landfall during its lifetime. On the other hand, these storms are quasi-stationary or very slow moving so that, when convection happens close to the shoreline, it is normally very dangerous and in many cases can cause very severe weather, with flash floods or tornadoes. An example of these extreme events is one of the case study analysed in this work, regarding the flash flood occurred in Giampileri (Sicily, Italy) the evening of 1st October 2009, where 18 people died, other 79 injured and the historical centre of the village seriously damaged. Severe weather systems and strong convection occurring in the Mediterranean basin have been investigated for two years (2008-2009) using geostationary (MSG) and polar orbiting (AVHRR) satellite data, supported by ECMWF analyses and severe

  16. Paediatric asthma outpatient care by asthma nurse, paediatrician or general practitioner: Randomised controlled trial with two-year follow-up

    OpenAIRE

    Kuethe, Maarten; Vaessen-Verberne, Anja; Mulder, Paul; Bindels, Patrick; Aalderen, Willem

    2011-01-01

    textabstractAims: For children with stable asthma, to test non-inferiority of care provided by a hospital-based specialised asthma nurse versus a general practitioner (GP) or paediatrician. Methods: Randomised controlled trial evaluating standard care by a GP, paediatrician or an asthma nurse, with two-year follow-up. Results: 107 children were recruited, 45 from general practice and 62 from hospital. After two years, no significant differences between groups were found for airway responsiven...

  17. Two years of growth hormone therapy in young children with Prader-Willi syndrome: physical and neurodevelopmental benefits.

    Science.gov (United States)

    Myers, Susan E; Whitman, Barbara Y; Carrel, Aaron L; Moerchen, Victoria; Bekx, M Tracy; Allen, David B

    2007-03-01

    Infants with Prader-Willi syndrome (PWS) typically display failure to thrive and decreased muscle mass with excess body fat for age. Growth hormone (GH) therapy in children with PWS improves, but does not normalize, body composition and muscle strength and agility. The objective of this study was to determine the effects of earlier GH therapy on anthropometric measurements, body composition, and psychomotor development in affected PWS infants and toddlers. Twenty-five subjects, ages 4-37 months, were randomized to 2 years of GH therapy (1 mg/m(2)/day) or 1 year of observation without GH treatment and then placed on GH (1.5 mg/m(2).day) for 1 year only. Anthropometric measurements were obtained by standard methods: percent body fat, lean body mass, and total body bone mineral density by dual x-ray absorptiometry; motor constructs of mobility and stability by the Toddler Infant Motor Evaluation; and cognitive and language function by the Capute Scales of Infant Language and Cognitive Development. GH-treated PWS subjects demonstrated normalization of length/height standard deviation scores (SDS), faster head growth, increased lean body mass accrual, and decreased percent body fat (P < 0.005 for all parameters), as well as improved language (P = 0.05) and cognitive (P = 0.02) quotient Z-scores compared with similarly aged untreated PWS subjects after 1 year into the study. PWS subjects treated before their first birthday spoke their first words at a mean age of 14.4 +/- 2.8 months and walked independently at 23.3 +/- 4.8 months. GH therapy was well-tolerated; however, one PWS subject experienced scoliosis progression. As greater benefits were seen in our study with early treatment, prompt referral to a pediatric endocrinologist for consideration of GH therapy is recommended for PWS at an early age. (c) 2006 Wiley-Liss, Inc.

  18. Stabilizing Niger

    DEFF Research Database (Denmark)

    Hahonou, Eric Komlavi

    international intervention in Niger. Their main objective is to secure their own strategic, economic and political interests by strengthening the Nigerien authorities through direct intervention and capacity building activities. For western states reinforcing state security institutions and stabilizing elite...

  19. Food Fortification Stability Study

    Science.gov (United States)

    Abdulmalik, T. O.; Cooper, M. R.; Douglas, G. L.

    2015-01-01

    NASA has established the goal of traveling beyond low-Earth orbit and extending manned exploration to Mars. The extended length of a Mars mission, along with the lack of resupply missions increases the importance of nutritional content in the food system. The purpose of this research is to assess the stability of vitamin supplementation in traditionally processed spaceflight foods. It is expected that commercially available fortificants will remain stable through long-duration missions if proper formulation, processing, and storage temperatures are all achieved. Five vitamins (vitamin E, vitamin K, pantothenic acid, folic acid, and thiamin) were blended into a vitamin premix (DSM, Freeport, TX); premixes were formulated to be compatible with current processing techniques (retort or freeze-dried), varied water activities (high or low), and packaging material. The overall goal of this process is to provide 25% of the recommended daily intake of each vitamin (per serving), following processing and two years of ambient storage. Four freeze-dried foods (Scrambled Eggs, Italian Vegetables, Potatoes Au Gratin, Noodles and Chicken) and four thermostabilized foods (Curry Sauce with Vegetables, Chicken Noodle Soup, Grilled Pork Chop, Rice with Butter) were produced (with and without the vitamin premix), to assess the impact of the added fortificant on color and taste, and to determine the stability of supplemental vitamins in spaceflight foods. The use of fortification in spaceflight foods appears to be a plausible mitigation step to inadequate nutrition. This is due to the ease of vitamin addition as well as the sustainability of the premixes through initial processing steps. Postprocessing analysis indicated that vitamin fortification with this premix did not immediately impact organoleptic properties of the food. At this stage, the largest hurdle to fortification is the preciseness to which vitamins can be added; the total amount of vitamins required for production is 10

  20. Macroeconomic stability

    DEFF Research Database (Denmark)

    Jespersen, Jesper

    2004-01-01

    It is demonstrated that full employment and sustainable development not necessarily are conflicting goals. On the other hand macroeconomic stability cannot be obtained without a deliberate labour sharing policy and a shift in the composition of private consumption away from traditional material...

  1. Stabilized superconductors

    International Nuclear Information System (INIS)

    Wong, J.

    1975-01-01

    The stable, high field, high current composite wire comprises multiple filaments in a depleted bronze matrix, each filament comprising a type II superconducting, beta-tungsten structure, intermetallic compound layer jacketing and metallurgically bonded to a stabilizing copper core, directly or via an intermediate layer of refractory metal

  2. Marketing and Student Recruitment Practices at Four-Year and Two-Year Institutions, 2011. Noel-Levitz Report on Undergraduate Trends in Enrollment Management

    Science.gov (United States)

    Noel-Levitz, Inc, 2011

    2011-01-01

    What's working in student recruitment and marketing at the undergraduate level? To find out, Noel-Levitz conducted a 97-item, Web-based poll in April of 2011 as part of the firm's continuing series of benchmark polls for higher education. Among the findings: (1) The "top 10" most effective practices in 2011--across public and private, two-year and…

  3. Prolonged conservative care versus early surgery in patients with sciatica caused by lumbar disc herniation : two year results of a randomised controlled trial

    NARCIS (Netherlands)

    Peul, W.C.; Hout, van den W.B.; Brand, R.; Thomeer, R.T.W.M.; Koes, B.W.

    2008-01-01

    Objectives: To evaluate the effects of early lumbar disc surgery compared with prolonged conservative care for patients with sciatica over two years of follow-up. Design: Randomised controlled trial. Setting: Nine Dutch hospitals. Participants: 283 patients with 6-12 weeks of sciatica.

  4. From iTE to NQT: Evaluating Newly Qualified Teachers' Use of Mobile Technology in Their First Two Years of Teaching

    Science.gov (United States)

    Mac Mahon, Brendan; Ó'Grádaigh, Seán; Ghuidhir, Sinéad Ni

    2018-01-01

    This article outlines a study to examine if newly qualified teachers (NQTs) who had incorporated iPad within pedagogical practice during initial teacher education, continued to do so in their first two years of teaching, and also to identify the challenges to integration that emerged. Findings show that use of iPad in teaching, learning and…

  5. 28 CFR 79.35 - Proof of onset of leukemia at least two years after first exposure, and proof of onset of a...

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Proof of onset of leukemia at least two... Participants § 79.35 Proof of onset of leukemia at least two years after first exposure, and proof of onset of... be the date of first or initial exposure. The date of onset will be the date of diagnosis as...

  6. 28 CFR 79.25 - Proof of onset of leukemia at least two years after first exposure, and proof of onset of a...

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Proof of onset of leukemia at least two... leukemia at least two years after first exposure, and proof of onset of a specified compensable disease more than five years after first exposure. The date of onset will be the date of diagnosis as indicated...

  7. Driving Performance among Bioptic Telescope Users with Low Vision Two Years after Obtaining Their Driver's License: A Quasi-Experimental Study

    Science.gov (United States)

    Vincent, Claude; Lachance, Jean-Paul; Deaudelin, Isabelle

    2012-01-01

    This study sought to compare road safety of new drivers with low vision who have followed a specific pilot bioptic training program with other groups of drivers all matched for age and driving experience. A quasi-experimental design was used two years after drivers obtained their license. Drivers were classified in the experimental group (n = 10,…

  8. Designing Writing Assignments for Vocational-Technical Courses. A Guide for Teachers in the Two-Year College and Technical Institute.

    Science.gov (United States)

    Killingsworth, Jimmie, Ed.; And Others

    The 27 articles in this 6-part guide provide information on developing and implementing writing instruction as part of content-area courses in two-year vocational-technical colleges. Part One, General Concerns, includes "Making Writing Work for You in the Interactive Classroom" (Killingsworth, Rude); "Evaluating and Responding to Student Writing"…

  9. Two years of refurbishing the command and control apparatus: the Chinese Communist Party strengthens its hold on the judicial system and societal forces

    NARCIS (Netherlands)

    Stepan, M.

    2015-01-01

    The announcements two years ago sounded ambitious, raising hopes in Western observers that we would see greater economic and social openness in China: the market was to be given a “decisive role”, unprofitable state-owned enterprises were to be made more efficient, corruption in the state and Party

  10. University Environment Experience of the First Two Years of University Graduates at a Newly Established Small University Located in Suburban Area in Taiwan

    Science.gov (United States)

    Lin, Yii-Nii

    2011-01-01

    The purpose of this study is to describe students' university environment experience from the perspectives of the first two years of university graduates of a newly established small university located in suburban area in Taiwan. A qualitative method of phenomenology with in-depth interviews is adopted. Fourteen male and sixteen female seniors,…

  11. Cognitive performance in depressed older persons : the impact of vascular burden and remission. A two-year follow-up study

    NARCIS (Netherlands)

    Zuidersma, Marij; Comijs, Hannie C.; Naarding, Paul; Oude Voshaar, Richard C.

    Objectives: Depression is associated with an increased risk of cognitive decline. The present study compared two-year change in cognitive performance between depressed older persons and a non-depressed control group, between remitted and non-remitted patients, and evaluated whether vascular burden

  12. Cognitive bias modification and CBT as early interventions for adolescent social and test anxiety : Two-year follow-up of a randomized controlled trial

    NARCIS (Netherlands)

    de Hullu, Eva; Sportel, B. Esther; Nauta, Maaike H.; de Jong, Peter J.

    Background and Objectives: This two-year follow-up study evaluated the long-term outcomes of two early interventions that aimed at reducing social and test anxiety in young adolescents at risk for developing social anxiety disorder. Methods: In this RCP, moderately socially anxious adolescents

  13. A Study of the Impact of Default Management Practices and Other Factors on Student Loan Default Rates in Public Two-Year Community Colleges

    Science.gov (United States)

    Daniels, Randell W.

    2013-01-01

    Default management practices and their relationship to the student loan default rate in public two-year community colleges was the focus of this investigation. Five research questions regarding written default management plans, default management practices, process management, accountability, and other factors impacting default guided the study.…

  14. Interact for What? The Relationship between Interpersonal Interaction Based on Motivation and Educational Outcomes among Students in Manufacturing Programs at Two-Year Technical Colleges

    Science.gov (United States)

    Chan, Hsun-yu; Wang, Xueli

    2016-01-01

    Objective: This study explored the relationship between different types of interpersonal interaction, characterized by their underlying motivations, and educational outcomes among students in manufacturing programs at two-year colleges. While there exist several ways to classify interaction, motivation as an inherent attribute that fuels behaviors…

  15. Paediatric asthma outpatient care by asthma nurse, paediatrician or general practitioner: randomised controlled trial with two-year follow-up

    NARCIS (Netherlands)

    Kuethe, Maarten; Vaessen-Verberne, Anja; Mulder, Paul; Bindels, Patrick; van Aalderen, Wim

    2011-01-01

    For children with stable asthma, to test non-inferiority of care provided by a hospital-based specialised asthma nurse versus a general practitioner (GP) or paediatrician. Randomised controlled trial evaluating standard care by a GP, paediatrician or an asthma nurse, with two-year follow-up. 107

  16. Moments of Meeting: Difficulties and Developments in Shared Attention, Interaction, and Communication with Children with Autism during Two Years of Music Therapy in a Public Preschool Class

    Science.gov (United States)

    Barnes, Geoffrey Prescott

    2010-01-01

    Drawing upon video recordings over two years, teacher interviews, school reports, and field notes, this practitioner research study described and analyzed 16 video excerpts from a music therapy group in a public preschool class serving 14 children with autism, for durations ranging from two to sixteen months. The research centered on three of the…

  17. Two-Year Comparison of Transfer and Native Student Academic Performance: University of Illinois at Urbana-Champaign, Fall 1986 Group.

    Science.gov (United States)

    Heiser, Linda M.; Abbed, Nejla

    In 1989, a two-year study was completed comparing the academic progress of community college transfers, senior college transfers, and continuing juniors (natives) at the University of Illinois at Urbana-Champaign (UIUC). The study samples were comprised of 673 former community college students and 393 senior college transfers who entered UIUC in…

  18. Facing the Future: The Two-Year College, the Technician & the Entrepreneur. An International Symposium. Report from the Conference (Orlando, Florida, 1996).

    Science.gov (United States)

    Regional Technology Strategies, Inc., Carrboro, NC.

    This document reports on the proceedings of an international 2-day conference in Orlando, Florida that was supported by the National Science Foundation. At the conference, practitioners, employers, policymakers, and researchers raised and debated issues surrounding two-year colleges. The themes of the conference reflected increasing demands by…

  19. Short bowel patients treated for two years with glucagon-like Peptide 2: effects on intestinal morphology and absorption, renal function, bone and body composition, and muscle function

    DEFF Research Database (Denmark)

    Jeppesen, P B; Lund, P; Gottschalck, I B

    2009-01-01

    offered, to eleven SBS patients keeping parenteral support constant. 72-hour nutritional balance studies were performed at baseline, weeks 13, 26, 52 during two years intermitted by an 8-week washout period. In addition, mucosal morphometrics, renal function (by creatinine clearance), body composition...... and electrolyte absorption at lower oral intakes. This was accompanied by a 28% improvement in creatinine clearance....

  20. Investigation of the Public Library as a Linking Agent to Major Scientific, Educational, Social and Environmental Data Bases. Two-Year Interim Report. Annex 2: Publicity Aspects.

    Science.gov (United States)

    Summit, Roger K.; Firschein, Oscar

    Project Dialib was a two-year investigation of the impact of on line information retrieval in a public library setting. This volume documents the efforts that were made to publicize the project and to promote the use of the service among library patrons. (JY)

  1. An Infectious Pseudoaneurysm Caused by Ventricular Septal Defect Occluder in Patent Ductus Arteriosus Closure in a Two-Year-Old Child.

    Science.gov (United States)

    Li, Dingyang; Qiu, Qiu; Jin, Jing; Zhang, Changdong; Wang, Lijun; Zhang, Gangcheng

    2017-12-12

    We present a case of an infectious pseudoaneurysm after patent ductus arteriosus (PDA) closure with a ventricular septal defect (VSD) occluder in a two-year-old child. The aneurysm grew rapidly but was successfully removed in time and the patient survived. To our knowledge, this is the first report of an infectious pseudoaneurysm caused by VSD occluder in PDA closure.

  2. Two-Year Community: Tools for Success--A Study of the Resources and Study Habits of General Chemistry I Students at Two Community Colleges

    Science.gov (United States)

    Bruck, Laura B.; Bruck, Aaron D.

    2018-01-01

    Recruitment and retention in the sciences is both difficult and crucial, especially in the community college setting. In this study, the resources used by General Chemistry I students at two different public, predominantly two-year colleges in two states were studied via surveys for a semester. Data were analyzed with respect to student attitudes…

  3. Critical Professional Issues in Labour Force Development for Teachers with Children up to Two Years of Age: A New Zealand Perspective

    Science.gov (United States)

    Rockel, Jean

    2014-01-01

    This paper critically examines current concerns regarding professional issues in labour force development for teachers with children up to two years of age (UtoT). The concerns in New Zealand (NZ) relate to whether initial teacher-education (ITE) qualifications prepare teachers to work with children UtoT, involving synergy between ITE and the…

  4. Some views on the two-year review/revision cycle of the IAEA ''regulations for the safe transport of radioactive material''

    International Nuclear Information System (INIS)

    Fasten, C.; Nitsche, F.

    2004-01-01

    The ''Regulations for the Safe Transport of Radioactive Material'' of the International Atomic Energy Agency (IAEA), Vienna were last issued as a complete revised edition in 1996 as Safety Standards Series No. ST-1 [1]. A modification to this edition was made in 2000 - only in English - incorporating minor editorial corrections published as Safety Standards Series No. TS-R-1 (ST-1, Revised). Issues in French, Russian and Spanish followed shortly. A continuos review/revision process of the transport regulations was initiated in 2000 to publish an amended or a revised edition every two years. This two-year review cycle has been established to harmonise it with the review cycles of the other United Nations dangerous goods regulatory bodies, namely - the UN Committee of Experts on the Transport of Dangerous Goods, Geneva - the International Civil Aviation Organisation (ICAO), Montreal - the International Maritime Organisation (IMO), London and - the United Nations Economic Commission for Europe (UN-ECE) - Inland Transport Committee, Geneva. - Intergovernmental Organisation for International Carriage by rail (OTIF), Bern. These bodies are responsible to issue the regulations for the transport of all classes of dangerous goods (where the class 7 is ''Radioactive Material''), for the international air transport (ICAO), for the international maritime transport (IMO) and the European road, rail and inland waterway transport (UN-ECE, OTIF). The regulations of the above mentioned bodies have been published for many years within a two year period with good experience. Since 2000 the IAEA has been using the two-year cycle also. Based on this relative short time of application first experiences with this two-year cycle will be discussed

  5. Cost-effectiveness of minimally invasive versus open transforaminal lumbar interbody fusion for degenerative spondylolisthesis associated low-back and leg pain over two years.

    Science.gov (United States)

    Parker, Scott L; Adogwa, Owoicho; Bydon, Ali; Cheng, Joseph; McGirt, Matthew J

    2012-07-01

    Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) for lumbar spondylolisthesis allows for surgical treatment of back and leg pain while theoretically minimizing tissue injury and accelerating overall recovery. Although the authors of previous studies have demonstrated shorter length of hospital stay and reduced blood loss with MIS versus open-TLIF, short- and long-term outcomes have been similar. No studies to date have evaluated the comprehensive health care costs associated with TLIF procedures or assessed the cost-utility of MIS- versus open-TLIF. As such, we set out to assess previously unstudied end points of health care cost and cost-utility associated with MIS- versus open-TLIF. Thirty patients undergoing MIS-TLIF (n=15) or open-TLIF (n=15) for grade I degenerative spondylolisthesis associated back and leg pain were prospectively studied. Total back-related medical resource use, missed work, and health-state values (quality-adjusted life years [QALYs], calculated from EQ-5D with U.S. valuation) were assessed after two-year follow-up. Two-year resource use was multiplied by unit costs on the basis of Medicare national allowable payment amounts (direct cost) and work-day losses were multiplied by the self-reported gross-of-tax wage rate (indirect cost). Difference in mean total cost per QALY gained for MIS- versus open-TLIF was assessed as incremental cost-effectiveness ratio (ICER: COSTmis-COSTopen/QALYmis-QALYopen). MIS versus open-TLIF cohorts were similar at baseline. By two years postoperatively, patients undergoing MIS- versus open-TLIF reported similar mean QALYs gained (0.50 vs. 0.41, P=0.17). Mean total two-year cost of MIS- and open-TLIF was $35,996 and $44,727, respectively. The $8,731 two-year cost savings of MIS- versus open-TLIF did not reach statistical significance (P=0.18) for this sample size. Although our limited sample size prevented statistical significance, MIS- versus open-TLIF was associated with reduced costs over

  6. The Reduction of Baseline Serotonin 2A Receptors in Mild Cognitive Impairment is Stable at Two-year Follow-up

    DEFF Research Database (Denmark)

    Marner, Lisbeth; Knudsen, Gitte M; Madsen, Karine

    2011-01-01

    Alzheimer's disease (AD). In both patients and healthy subjects, no significant change in 5-HT2A receptor binding was found as compared to baseline values. In MCI patients, the average BPP in neocortex ranged from 1.49 to 2.45 at baseline and 1.38 to 2.29 at two-year follow-up; and in healthy subjects BPP...... ranged from 1.85 to 3.10 at baseline and 1.81 to 2.98 at two-year follow-up. The BPP of the patients that converted to AD during the follow-up period did not differ significantly from the patients that had not (yet) converted, neither at baseline, nor at follow-up. We conclude that the reduced levels...

  7. Effectiveness of the Intratissue Percutaneous Electrolysis (EPI®) technique and isoinertial eccentric exercise in the treatment of patellar tendinopathy at two years follow-up.

    Science.gov (United States)

    Abat, Ferran; Diesel, Wayne-J; Gelber, Pablo-E; Polidori, Fernando; Monllau, Joan-Carles; Sanchez-Ibañez, Jose-Manuel

    2014-04-01

    to show the effect of Intratissue Percutaneous Electrolysis (EPI®) combined with eccentric programme in the treatment of patellar tendinopathy. prospective study of 33 athlete-patients consecutively treated for insertional tendinopathy with Intratissue Percutaneous Electrolysis (EPI®) and followed for 2 years. Functional assessment was performed at the first visit, at three months and two years with the Tegner scale and VISA-P. an average improvement in the VISA-P of 35 points was obtained. The mean duration of treatment was 4.5 weeks. Some 78.8% of the patients returned to the same level of physical activity as before the injury by the end of treatment, reaching 100% at two years. intratissue percutaneous electrolysis (EPI®) combined with an eccentric-based rehab program offers excellent results in terms of the clinical and functional improvement of the patellar tendon with low morbidity in a short-term period. Therapy, level 4.

  8. Prevalence and Correlates of Problematic Internet Experiences and Computer-Using Time: A Two-Year Longitudinal Study in Korean School Children

    OpenAIRE

    Yang, Su-Jin; Stewart, Robert; Lee, Ju-Yeon; Kim, Jae-Min; Kim, Sung-Wan; Shin, Il-Seon; Yoon, Jin-Sang

    2014-01-01

    Objective To measure the prevalence of and factors associated with online inappropriate sexual exposure, cyber-bullying victimisation, and computer-using time in early adolescence. Methods A two-year, prospective school survey was performed with 1,173 children aged 13 at baseline. Data collected included demographic factors, bullying experience, depression, anxiety, coping strategies, self-esteem, psychopathology, attention-deficit hyperactivity disorder symptoms, and school performance. Thes...

  9. Paclitaxel-eluting stents versus everolimus-eluting coronary stents in a diabetic population: two-year follow-up of the TUXEDO-India trial.

    Science.gov (United States)

    Kaul, Upendra; Bhagwat, Ajit; Pinto, Brian; Goel, Praveen K; Jagtap, Prashant; Sathe, Shireesh; Wander, Gurpreet S; Arambam, Priyadarshini; Bangalore, Sripal

    2017-11-20

    The aim of this study was to report whether the superiority of the everolimus-eluting stent (EES) vs. the paclitaxel-eluting stent (PES) at one-year follow-up in the Taxus Element versus Xience Prime in a Diabetic Population (TUXEDO)-India trial was sustained at longer-term follow-up. One thousand eight hundred and thirty (1,830) patients with diabetes mellitus and coronary artery disease were randomised to EES vs. PES. Follow-up data up to two years were available in 1,701 (92.9%) patients. The primary endpoint was target vessel failure (TVF), defined as the composite of cardiac death, target vessel myocardial infarction (TV-MI), or ischaemia-driven target vessel revascularisation (TVR). Treatment with EES had a lower two-year rate of TVF (4.3% vs. 6.6%, p=0.03). Of the secondary endpoints, EES significantly reduced any MI (1.6% vs. 3.5%, p=0.01), TV-MI (0.7% vs. 3.1%, p=0.0001), ST (0.4% vs. 2.2%, p=0.001), cardiac death or target vessel MI (2.9% vs. 4.8%, p=0.04) and TLR (1.9% vs. 3.7%, p=0.02), compared with PES. Between one year and two years, no significant differences in the clinical outcomes were observed (pinteraction >0.05). In this adequately powered trial, the benefits of EES vs. PES in a diabetic population seen at one year were maintained at two years.

  10. Ultrasonographic observation of the healing process in the gap after a Ponseti-type Achilles tenotomy for idiopathic congenital clubfoot at two-year follow-up.

    Science.gov (United States)

    Niki, Hisateru; Nakajima, Hiroshi; Hirano, Takaaki; Okada, Hirokazu; Beppu, Moroe

    2013-01-01

    Ponseti management usually requires Achilles tenotomy during the final stage of serial casting. However, we lack a good understanding of the sequential tendon healing process after tenotomy in the Ponseti bracing protocol. The purpose of this study was to clarify the ultrasonographic process of tendon healing in the gap for up to two years after Ponseti-type Achilles tenotomy in patients with clubfeet. We conducted an ultrasonographic study to clarify the sequential changes in gap healing for up to two years after tenotomy. The subjects were 23 patients with 33 clubfeet. Achilles tenotomy was performed at mean 10.4 (8-16) weeks after birth. Dynamic and static ultrasonography was performed before tenotomy and at 1, 2, 3, 4, 6, 8, and 12 weeks as well as at 4, 6, 12, 18, and 24 months after tenotomy. Continuity and gliding were noted within four weeks. The united portion continued to thicken for up to three months after tenotomy. Starting from the fourth month, the healed portion began to lose its thickness, and this process continued into the sixth month. At one year, the thickness of the tendon did not differ much from that of the tendon on the opposing foot. In cases where patients had clubfoot on both feet and underwent simultaneous tenotomies, measurement of the tendons could not be accurately compared. At two years after tenotomy, slight irregularity of the internal structure persisted when compared with the unaffected foot. In addition, clinical and X-ray findings were evaluated simultaneously, and no recurrence was confirmed. To our knowledge, our results are the first to describe the process of gap healing in the tendon after tenotomy up to and beyond two years, as recommended in the Ponseti bracing protocol. Level of evidence IV.

  11. Trends in physical activity, health-related fitness, and gross motor skills in children during a two-year comprehensive school physical activity program.

    Science.gov (United States)

    Brusseau, Timothy A; Hannon, James C; Fu, You; Fang, Yi; Nam, Kahyun; Goodrum, Sara; Burns, Ryan D

    2018-01-06

    The purpose of this study was to examine the trends in school-day step counts, health-related fitness, and gross motor skills during a two-year Comprehensive School Physical Activity Program (CSPAP) in children. Longitudinal trend analysis. Participants were a sample of children (N=240; mean age=7.9±1.2 years; 125 girls, 115 boys) enrolled in five low-income schools. Outcome variables consisted of school day step counts, Body Mass Index (BMI), estimated VO 2 Peak , and gross motor skill scores assessed using the Test of Gross Motor Development-3rd Edition (TGMD-3). Measures were collected over a two-year CSPAP including a baseline and several follow-up time-points. Multi-level mixed effects models were employed to examine time trends on each continuous outcome variable. Markov-chain transition models were employed to examine time trends for derived binary variables for school day steps, BMI, and estimated VO 2 Peak . There were statistically significant time coefficients for estimated VO 2 Peak (b=1.10mL/kg/min, 95% C.I. [0.35mL/kg/min-2.53mL/kg/min], p=0.009) and TGMD-3 scores (b=7.8, 95% C.I. [6.2-9.3], p<0.001). There were no significant changes over time for school-day step counts or BMI. Boys had greater change in odds of achieving a step count associating with 30min of school day MVPA (OR=1.25, 95% C.I. [1.02-1.48], p=0.044). A two-year CSPAP related to increases in cardio-respiratory endurance and TGMD-3 scores. School day steps and BMI were primarily stable across the two-year intervention. Copyright © 2018 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  12. Do lifestyle factors and general health predict dropout among recently qualified eldercare workers? A two-year follow-up study.

    Science.gov (United States)

    Giver, Hanne; Faber, Anne; Strøyer, Jesper; Hannerz, Harald; Albertsen, Karen

    2011-05-01

    The eldercare sector in Denmark as in many industrialised countries is characterised by difficulties in retaining labour. Research suggests a possible imbalance between lifestyle and health among eldercare trainees and the demanding work encountered as eldercare employees. The aim of the present study was to determine the predictive effect of lifestyle and self-rated health on dropout from the Danish eldercare sector two years after qualification. We included 4,526 female eldercare trainees in the analyses of lifestyle parameters and 5,023 in the analyses of self-rated health. The participants in this prospective study were recruited from 27 of the 28 Danish colleges for eldercare. We linked survey data with national register data to obtain information about labour market attachment two years after qualification. The results of the present study showed that the poorer self-rated health, the higher the risk for dropout from the labour market (p lifestyle. We found that overweight/obesity (p = 0.0021 and p = 0.0012) as well as smoking (p = 0.0017) decreased the risk of dropout from eldercare into education. We found no support for increased likelihood of dropout among physically inactive. The results of the present study show that a poorer self-rated health is a predictor for dropout, not only from the eldercare two years after qualification, but from the labour market as a whole. However, the results were less consistent regarding the predictive effect of a detrimental lifestyle on dropout.

  13. Before Stabilization

    DEFF Research Database (Denmark)

    Plesner, Ursula; Horst, Maja

    2013-01-01

    of the communication about innovations in information and communication technology (ICT), and to contribute to an understanding of how different visions promise particular future configurations of workflows, communication processes, politics, economic models and social relations. Hereby, the paper adds...... to the literature on the relationship between ICTs and organizing, but with a distinct focus on innovation communication and distributed innovation processes taking place before ICTs are stabilized, issues which cannot be captured by studies of diffusion and adaptation of new ICTs within single organizations....

  14. Mid-term study of transcatheter aortic valve implantation in an Asian population with severe aortic stenosis: two-year Valve Academic Research Consortium-2 outcomes.

    Science.gov (United States)

    Chew, Nicholas; Hon, Jimmy Kim Fatt; Yip, Wei Luen James; Chan, Siew Pang; Poh, Kian-Keong; Kong, William Kok-Fai; Teoh, Kristine Leok Kheng; Yeo, Tiong Cheng; Tan, Huay Cheem; Tay, Edgar Lik Wui

    2017-09-01

    Transcatheter aortic valve implantation (TAVI) is an effective treatment for high-risk or inoperative patients with severe aortic stenosis. Given the unique characteristics of Asian populations, questions regarding mid-term outcomes in Asians undergoing TAVI have yet to be addressed. We evaluated the two-year clinical outcomes of TAVI in an Asian population using Valve Academic Research Consortium-2 definitions. This prospective study recruited 59 patients from a major academic medical centre in Singapore. The main outcomes were two-year survival rates, peri-procedural complications, symptom improvement, valvular function and assessment of learning curve. Mean age was 76.8 years (61.0% male), mean body surface area 1.6 m 2 and mean logistic EuroSCORE 18.7%. Survival was 93.2%, 86.0% and 79.1% at 30 days, one year and two years, respectively. At 30 days post TAVI, the rate of stroke was 1.7%, life-threatening bleeding 5.1%, acute kidney injury 25.0%, major vascular complication 5.1%, and new permanent pacemaker implantation 6.8%. 29.3% of TAVI patients were rehospitalised (47.1% cardiovascular-related) within one year. These composite outcomes were measured: device success (93.2%); early safety (79.7%); clinical efficacy (66.1%); and time-related valve safety (84.7%). Univariate analysis found these predictors of two-year all-cause mortality: logistic EuroSCORE (hazard ratio [HR] 1.07; p < 0.001); baseline estimated glomerular filtration rate (HR 0.97; p = 0.048); and acute kidney injury (HR 5.33; p = 0.022). Multivariate analysis identified non-transfemoral TAVI as a predictor of cardiovascular-related two-year mortality (HR 14.64; p = 0.008). Despite the unique clinical differences in Asian populations, this registry demonstrated favourable mid-term clinical and safety outcomes in Asians undergoing TAVI. Copyright: © Singapore Medical Association

  15. Mobility Modification Alleviates Environmental Influence on Incident Mobility Difficulty among Community-Dwelling Older People: A Two-Year Follow-Up Study

    Science.gov (United States)

    Portegijs, Erja; Viljanen, Anne; Iwarsson, Susanne; Rantanen, Taina

    2016-01-01

    Background Environmental barriers increase risk for mobility difficulties in old age. Mobility difficulty is preceded by a phase where people try to postpone a difficulty through mobility modification. We studied whether perceived environmental mobility barriers outdoors correlate with mobility modification and mobility difficulty, predict development of mobility difficulty over a two-year follow-up, and whether mobility modification alleviates the risk for difficulty. Methods At baseline, 848 people aged 75–90 were interviewed face-to-face. Telephone follow-up interviews were conducted one (n = 816) and two years (n = 761) later. Environmental barriers to mobility were self-reported using a15-item structured questionnaire at baseline, summed and divided into tertiles (0, 1 and 2 or more barriers). Mobility difficulty was assessed as self-reported ability to walk 2 km at all assessment points and categorized into ‘no difficulty’, ‘no difficulty but mobility modifications’ (reducing frequency, stopping walking, using an aid, slowing down or resting during the performance) and ‘difficulty’. Results At baseline, 212 participants reported mobility modifications and 356 mobility difficulties. Those reporting one or multiple environmental barriers had twice the odds for mobility modifications and up to five times the odds for mobility difficulty compared to those reporting no environmental barriers. After multiple adjustments for health and functioning, reporting multiple environmental barriers outdoors continued to predict the development of incident mobility difficulty over the two-year follow-up. Mobility modifications attenuated the association. Conclusion For older people who successfully modify their performance, environmental influence on incident mobility difficulty can be diminished. Older people use mobility modification to alleviate environmental press on mobility. PMID:27104750

  16. Perceived environmental barriers to outdoor mobility and changes in sense of autonomy in participation outdoors among older people: a prospective two-year cohort study.

    Science.gov (United States)

    Rantakokko, Merja; Portegijs, Erja; Viljanen, Anne; Iwarsson, Susanne; Kauppinen, Markku; Rantanen, Taina

    2017-08-01

    The aim was to study whether perceived environmental barriers to outdoor mobility affect changes in sense of autonomy in participation outdoors among community-dwelling older people over a two-year period. Community-dwelling people aged 75-90 years (n = 848) in central Finland were interviewed on two occasions, face-to-face at baseline and over the telephone two years later. Perceived environmental barriers to outdoor mobility were assessed using a 15-item structured questionnaire, and the sum scores categorized into tertiles (0, 1 and 2 or more barriers). Autonomy in participation outdoors was assessed with the 'Impact on Participation and Autonomy' (IPA) questionnaire using the autonomy outdoors subscale (score range 0-20, higher scores indicating more restricted autonomy). Scores for autonomy in participation outdoors were available for 848 participants at baseline (mean 6.2, SD = 3.8) and for 748 participants at the two-year follow-up (mean 6.7, SD = 3.9). At baseline, those reporting multiple environmental barriers had the most restricted autonomy, while those reporting no environmental barriers had the least restricted autonomy (p autonomy in participation outdoors declined more among those reporting multiple environmental barriers compared to those reporting none (age- and sex-adjusted group*time β = .629, s.e. = .277, p = .023). Adjustment for cognitive functioning, education, number of chronic conditions and change in walking difficulty did not influence the association. Perceived environmental barriers to outdoor mobility accelerate the decline in autonomy in participation outdoors among older community-dwelling people. Understanding factors affecting autonomy can help in finding ways to support the sense of autonomy as people age.

  17. Point-of-care controls for nosocomial legionellosis combined with chlorine dioxide potable water decontamination: a two-year survey at a Welsh teaching hospital.

    Science.gov (United States)

    Hosein, I K; Hill, D W; Tan, T Y; Butchart, E G; Wilson, K; Finlay, G; Burge, S; Ribeiro, C D

    2005-10-01

    This study reports a two-year programme of attempted eradication of Legionella colonization in the potable water supply of a 1000-bed tertiary care teaching hospital in Wales. There was a simultaneous, point-of-care, sterile-water-only policy for all intensive care units (ICU) and bone marrow and renal transplant units in order to prevent acquisition of nosocomial Legionnaires' disease. The programme was initiated following a case of nosocomial pneumonia caused by Legionella pneumophila serogroup 1-Bellingham-like genotype A on the cardiac ICU. The case occurred 14 days after mitral and aortic valve replacement surgery. Clinical and epidemiological investigations implicated aspiration of hospital potable water as the mechanism of infection. Despite interventions with chlorine dioxide costing over 25000 UK pounds per annum, Legionella has remained persistently present in significant numbers (up to 20000 colony forming units/L) and with little reduction in the number of positive sites. Two further cases of nosocomial disease occurred over the following two-year period; in one case, aspiration of tap water was implicated again, and in the other case, instillation of contaminated water into the right main bronchus via a misplaced nasogastric tube was implicated. These cases arose because of inadvertent non-compliance with the sterile-water-only policy in high-risk locations. Enhanced clinical surveillance over the same two-year period detected no other cases of nosocomial disease. This study suggests that attempts at eradication of Legionella spp. from complex water systems may not be a cost-effective measure for prevention of nosocomial infections, and to the best of our knowledge is the first study from the UK to suggest that the introduction of a sterile-water-only policy for ICUs and other high-risk units may be a more cost-effective approach.

  18. Effects of two-year testosterone replacement therapy on cognition, emotions and quality of life in young and middle-aged hypogonadal men.

    Science.gov (United States)

    Lašaitė, L; Čeponis, J; Preikša, R T; Žilaitienė, B

    2017-04-01

    The aim of the study was to examine the effects of two-year testosterone replacement therapy on cognitive functioning, emotional state and quality of life in young and middle-aged men with hypogonadotropic hypogonadism. Nineteen males diagnosed with hypogonadotropic hypogonadism participated in the study. Cognitive functions were assessed by Trail Making Test and Digit Span Test of Wechsler Adult Intelligence Scale. Emotional state was evaluated by Profile of Mood States. Quality of life was evaluated by WHO Brief Quality of Life Questionnaire. Changes after two-year testosterone replacement therapy were detected in Trail Making A (42.9 ± 22.3 vs. 36.2 ± 22.5, p = .050) and B (90.6 ± 55.3 vs. 65.6 ± 21.4, p = .025) tests, showing improvement in attention and visual scanning abilities, executive function and psychomotor speed, as well as in Digit Span Test forward score (5.4 ± 2.0 vs. 6.1 ± 2.6, p = .046), showing improvement in attention capacity and psychomotor speed. No significant differences were observed in emotional state and quality of life. In conclusion, beneficial effect in cognitive functioning (improved attention and visual scanning ability, executive function and psychomotor speed), but not in emotional state and quality of life, was observed in young and middle-aged hypogonadal men after two-year testosterone replacement therapy. © 2016 Blackwell Verlag GmbH.

  19. Early-life gut bacteria associate with IL-4-, IL-10- and IFN-γ production at two years of age.

    Directory of Open Access Journals (Sweden)

    Maria A Johansson

    Full Text Available Microbial exposure early in life influences immune maturation and potentially also the development of immune-mediated disease. Here we studied early-life gut colonization in relation to cytokine responses at two years of age. Fecal samples were collected from infants during the first two months of life. DNA was extracted from the fecal samples and Bifidobacterium (B. adolescentis, B. breve, B. bifidum, a group of lactobacilli (L. casei, L. paracasei and L. rhamnosus as well as Staphylococcus (S. aureus were detected with real time PCR. Peripheral mononuclear cells were stimulated with phytohaemagglutinin (PHA and numbers of IL-4-, IL-10- and IFN-γ secreting cells were evaluated using ELISpot. We further stimulated peripheral blood mononuclear cells with bacterial supernatants in vitro and assessed the IL-4-, IL-10- and IFN-γ inducing capacity by flow cytometry and ELISA. Early S. aureus colonization associated with higher numbers of IL-4- (p = 0.022 and IL-10 (p = 0.016 producing cells at two years of age. In contrast to colonization with S. aureus alone, co-colonization with lactobacilli associated with suppression of IL-4- (p = 0.004, IL-10- (p = 0.004 and IFN-γ (p = 0.034 secreting cells. In vitro stimulations of mononuclear cells with bacterial supernatants supported a suppressive role of L. rhamnosus GG on S. aureus-induced cytokine responses. We demonstrate that the early gut colonization pattern associates with the PHA-induced cytokine profile at two years of age and our in vitro findings support that specific bacterial species influence the T helper cell subsets. This suggests that dysbiosis in the early microbiota may modulate the risk of developing inflammatory conditions like allergy.

  20. An intervention to improve program implementation: findings from a two-year cluster randomized trial of Assets-Getting To Outcomes

    Science.gov (United States)

    2013-01-01

    Background Studies have shown that communities have not always been able to implement evidence-based prevention programs with quality and achieve outcomes demonstrated by prevention science. Implementation support interventions are needed to bridge this gap between science and practice. The purpose of this article is to present two-year outcomes from an evaluation of the Assets Getting To Outcomes (AGTO) intervention in 12 Maine communities engaged in promoting Developmental Assets, a positive youth development approach to prevention. AGTO is an implementation support intervention that consists of: a manual of text and tools; face-to-face training, and onsite technical assistance, focused on activities shown to be associated with obtaining positive results across any prevention program. Methods This study uses a nested and cross-sectional, cluster randomized controlled design. Participants were coalition members and program staff from 12 communities in Maine. Each coalition nominated up to five prevention programs to participate. At random, six coalitions and their respective 30 programs received the two-year AGTO intervention and the other six maintained routine operations. The study assessed prevention practitioner capacity (efficacy and behaviors), practitioner exposure to and use of AGTO, practitioner perceptions of AGTO, and prevention program performance. Capacity of coalition members and performance of their programs were compared between the two groups across the baseline, one-, and two-year time points. Results We found no significant differences between AGTO and control group’s prevention capacity. However, within the AGTO group, significant differences were found between those with greater exposure to and use of AGTO. Programs that received the highest number of technical assistance hours showed the most program improvement. Conclusions This study is the first of its kind to show that use of an implementation support intervention-AGTO -yielded

  1. Campus-Based, Community-Based, and Philanthropic Contributions to Predoctoral Pediatric Dental Clinical Education: Two Years of Experiences at One Dental College.

    Science.gov (United States)

    Spiritoso, Stephen; Gross, Erin; Bean, Canise Y; Casamassimo, Paul S; Levings, Kevin; Lloyd, Patrick

    2015-08-01

    The aim of this study was to investigate the contribution of a tiered predoctoral pediatric dentistry clinical education model to competency achievement by dental students over a two-year clinical education. Retrospective data were obtained for academic years 2012-13 and 2013-14 from three sources: a campus-based, dental school-housed clinic; division-directed clinics in community-based pediatric and special needs clinics (DDC); and clinics affiliated with the dental college's community-based dental education (CBDE) program, the OHIO Project (OP). A fourth dataset was obtained for the same two-year period from a biannual clinic event held at the college in conjunction with Give Kids a Smile Day (GKAS). Procedures considered essential to the care of children were sorted by 12 dental codes from all services for patients 18 years of age and younger. The dental school clinic provided 11,060 procedures; the DDC, 28,462; the OP, 17,863; and GKAS, 2,028. The two-year total was 59,433 procedures. Numbers of diagnostic and preventive procedures were 19,441, restorative procedures were 13,958, and pulp and surgical procedures were 7,392. Site contribution ranged from 52.2 to 144.9 procedures per attending student, with the DDC yielding the highest per student average for each year (126.4 and 144.9) and the dental school clinic the lowest (52.2 and 53.1). This study found that a combination of school-based, community-based, and philanthropic pediatric dental experiences offered a large number of essential pediatric dentistry experiences for predoctoral dental students, with CBDE opportunities offering the largest contribution.

  2. Treatment of Osteoarthritis of the Knee with a Combination of Autologous Conditioned Serum and Physiotherapy: A Two-Year Observational Study.

    Science.gov (United States)

    Baselga García-Escudero, Jaime; Miguel Hernández Trillos, Pedro

    2015-01-01

    Autologous conditioned serum (ACS) is an autologous blood product that has shown efficacy against knee osteoarthritis (OA) in randomized controlled trials. However, there are few reports of its effectiveness in everyday practice. Here, we report clinical efficacy results from a two-year prospective observational study of patients with highly symptomatic knee OA who received ACS in conjunction with physiotherapy. 118 patients with unilateral knee OA (Kellgren-Lawrence grades I-IV), who were candidates for surgery but instead chose conservative treatment, were treated with a combination of four intra-articular injections of ACS (2 mL each) once weekly over four weeks and subsequent physiotherapy applied 4 weeks after ACS injection. Main endpoints of the study were pain (Numeric Rating Scale [NRS]) assessed at 0, 3, 6, 12 and 24 months, and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) global score, assessed at 0 and 24 months. The effect size (Cohen's d) was calculated for pain and WOMAC outcomes, with effect sizes >0.8 considered large. By 3 months, there were significant improvements in pain (NRS) from baseline (-63.0%, p5) and WOMAC improvement (8.0-13.6) were very large. Only one patient received total knee joint replacement during the study. Clinical improvement did not correlate with gender, age, Kellgren-Lawrence grade, or body mass index. Treatment with ACS and physiotherapy produced a rapid decline in pain, which was sustained for the entire two years of the study. This was accompanied by a large improvement in WOMAC scores at two years. These results confirm that ACS combined with physiotherapy is an effective treatment for OA of the knee.

  3. Treatment of Osteoarthritis of the Knee with a Combination of Autologous Conditioned Serum and Physiotherapy: A Two-Year Observational Study.

    Directory of Open Access Journals (Sweden)

    Jaime Baselga García-Escudero

    Full Text Available Autologous conditioned serum (ACS is an autologous blood product that has shown efficacy against knee osteoarthritis (OA in randomized controlled trials. However, there are few reports of its effectiveness in everyday practice. Here, we report clinical efficacy results from a two-year prospective observational study of patients with highly symptomatic knee OA who received ACS in conjunction with physiotherapy.118 patients with unilateral knee OA (Kellgren-Lawrence grades I-IV, who were candidates for surgery but instead chose conservative treatment, were treated with a combination of four intra-articular injections of ACS (2 mL each once weekly over four weeks and subsequent physiotherapy applied 4 weeks after ACS injection. Main endpoints of the study were pain (Numeric Rating Scale [NRS] assessed at 0, 3, 6, 12 and 24 months, and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC global score, assessed at 0 and 24 months. The effect size (Cohen's d was calculated for pain and WOMAC outcomes, with effect sizes >0.8 considered large.By 3 months, there were significant improvements in pain (NRS from baseline (-63.0%, p5 and WOMAC improvement (8.0-13.6 were very large. Only one patient received total knee joint replacement during the study. Clinical improvement did not correlate with gender, age, Kellgren-Lawrence grade, or body mass index.Treatment with ACS and physiotherapy produced a rapid decline in pain, which was sustained for the entire two years of the study. This was accompanied by a large improvement in WOMAC scores at two years. These results confirm that ACS combined with physiotherapy is an effective treatment for OA of the knee.

  4. Food Fortification Stability Study

    Science.gov (United States)

    Sirmons, T.; Cooper, M.; Douglas, G.

    2017-01-01

    NASA has established the goal of traveling beyond low-Earth orbit and extending manned exploration to Mars. The length of proposed Mars missions and the lack of resupply missions increases the importance of nutritional content in the food system, which will need a five-year shelf life. The purpose of this research is to assess the stability of vitamin supplementation in traditionally processed spaceflight foods. It is expected that commercially available fortification nutrients will remain stable through a long duration exploration mission at sufficient levels if compatible formulation, processing, and storage temperatures are achieved. Five vitamins (vitamin E, vitamin K, pantothenic acid, folic acid, and thiamin) were blended into a vitamin premix (DSM, Freeport, TX) such that the vitamin concentration per serving equaled 25% of the recommended daily intake after two years of ambient storage. Four freeze-dried foods (Scrambled Eggs, Italian Vegetables, Potatoes Au Gratin, Noodles and Chicken) and four thermo-stabilized foods (Curry Sauce with Vegetables, Chicken Noodle Soup, Grilled Pork Chop, Rice with Butter) were produced, with and without the vitamin premix, to assess the impact of the added fortification on color and taste and to determine the stability of supplemental vitamins in spaceflight foods. The addition of fortification to spaceflight foods did not greatly alter the organoleptic properties of most products. In most cases, overall acceptability scores remained above 6.0 (minimum acceptable score) following six months and one year of low-temperature storage. Likewise, the color of fortified products appears to be preserved over one year of storage. The only exceptions were Grilled pork Chop and Chicken Noodle Soup whose individual components appeareddegrade rapidly over one year of storage. Finally, most vitamins appeared to be stable during long-term storage. The only exception was thiamin, which degraded rapidly during the first year of storage at

  5. Can the UN Stabilize Mali? Towards a UN Stabilization Doctrine?

    Directory of Open Access Journals (Sweden)

    Arthur Boutellis

    2015-06-01

    Full Text Available Almost two years after the deployment of the United Nations Multidimensional Integrated Stabilization Mission in Mali (MINUSMA in July 2013, the increasing number of asymmetric terrorist attacks targeting UN peacekeepers – in the context of a drawn-out peace process – has raised a number of questions in Mali, the sub-region, and in New York, over the relevance and adequacies of MINUSMA’s mandate and capabilities. It also raises a broader issue, of whether the consent-based UN peacekeeping tool is appropriate and can be effective in carrying out stabilization mandates in such a context and what doctrine such operations should be based on. The UN is indeed under increasing pressure from host countries and some African troop-contributing countries to go on the offensive. Member States have also increasingly recognized terrorism and organized crime as a strategic threat, and while opposed to the UN directly engaging in counterterrorism (CT operations, some may wish to see the UN playing a greater stabilization role following the January 2013 French military intervention in Mali. However, little guidance and means have been given so far to UN missions for dealing with such threats and implementing effective stabilization mandates. The High-Level Panel on Peace Operations, which recently released its report, noted that the usage of the term “stabilization” by the UN requires clarification. This article analyses the complex and evolving nature of threats in northern Mali and implications for MINUSMA and describes the military and political tools – including mediation – so far available within and outside the UN. The article concludes that the UN is bound to move towards stabilization when and if deployed in contexts such as Mali’s if it wants to remain relevant. However, such a move should be based on an overarching UN stabilization doctrine and context-specific UN-wide stabilization strategies which are first and foremost political

  6. Two years follow-up study of the pain-relieving effect of gold bead implantation in dogs with hip-joint arthritis

    Directory of Open Access Journals (Sweden)

    Søli Nils

    2007-03-01

    Full Text Available Abstract Seventy-eight dogs with pain from hip dysplasia participated in a six-month placebo-controlled, double-blinded clinical trial of gold bead implantation. In the present, non-blinded study, 73 of these dogs were followed for an additional 18 months to evaluate the long-term pain-relieving effect of gold bead implantation. The recently-published results of the six month period revealed that 30 of the 36 dogs (83% in the gold implantation group showed significant improvement (p = 0.02, included improved mobility and reduction in the signs of pain, compared to the placebo group (60% improvement. In the long-term two-year follow-up study, 66 of the 73 dogs had gold implantation and seven dogs continued as a control group. The 32 dogs in the original placebo group had gold beads implanted and were followed for a further 18 months. A certified veterinary acupuncturist used the same procedure to insert the gold beads as in the blinded study, and the owners completed the same type of detailed questionnaires. As in the blinded study, one investigator was responsible for all the assessments of each dog. The present study revealed that the pain-relieving effect of gold bead implantation observed in the blinded study continued throughout the two-year follow-up period.

  7. Two-year impact of the Spanish smoking law on exposure to secondhand smoke: evidence of the failure of the 'Spanish model'.

    Science.gov (United States)

    López, Maria J; Nebot, Manel; Schiaffino, Anna; Pérez-Ríos, Mónica; Fu, Marcela; Ariza, Carles; Muñoz, Gloria; Fernández, Esteve

    2012-07-01

    Studies evaluating the long-term impact of smoking laws on secondhand smoke (SHS) exposure using airborne markers are scarce. This study aimed to assess the long-term impact of the Spanish smoking law on SHS levels, using a specific and objective marker. Follow-up study, measuring vapour-phase nicotine levels before the implementation of the law and 6, 12 and 24 months after the initial assessment. A total of 443 samples were taken at baseline in eight different regions in offices in the public administration, private sector, universities and hospitality venues. Two years after the law was implemented, the nicotine concentration decreased by a minimum of 60% in public administration, university and private sector offices, as well as in venues where smoking was totally banned. However, nicotine levels significantly increased by 40% in hospitality venues allowing smoking. No significant differences were found in hospitality venues with areas for smokers and non-smokers or in pubs and discotheques. Two years after the smoking law came into force, levels of SHS exposure in the workplace were significantly lower than before the law was implemented. Importantly, however, SHS levels were even higher than before the law was implemented in venues still allowing smoking. The data obtained in this study clearly show that the 'Spanish model' is not protecting the health of hospitality workers and that a complete ban is required. Furthermore, this study highlights the importance of long-term monitoring of compliance with smoking laws over time.

  8. Effects of Lifetime Unemployment Experience and Job Insecurity on Two-Year Risk of Physician-Diagnosed Incident Depression in the German Working Population.

    Science.gov (United States)

    Wege, Natalia; Angerer, Peter; Li, Jian

    2017-08-11

    Unemployment and job insecurity have been reported to be associated with a higher risk of depression. The purpose of this study was to evaluate the separate and combined effects of lifetime unemployment experience and job insecurity on the incidence of depression in an unselected working population in Germany. Data from the German Socio-Economic Panel (GSOEP) study were used, as was a final sample of those currently employed, with complete data at baseline (2009) and follow-up (2011) restricted to those free of depression in 2009 ( n = 7073). Poisson regression analysis was applied to test the prospective associations between unemployment, job insecurity, and a two-year incident of depression. Results showed that the experience of unemployment and perceived job insecurity were significantly associated with a higher risk of depression during the two-year follow-up (risk ratios 1.64; 95% confidence intervals (1.16, 2.31) and risk ratios 1.48; 95% confidence intervals (1.13, 1.92), respectively). Notably, the strongest risk was observed among participants with insecure jobs and past long-term unemployment (risk ratios 2.15; 95% confidence intervals (1.32; 3.52)). In conclusion, even during employment, the experience of lifetime unemployment led to a higher risk of depression. The combination of previous unemployment experience and anticipated job insecurity increased the risk of developing depression. Results support health promotion with special emphasis on unemployment and precarious working conditions.

  9. The Feasibility of Functional Electrical Stimulation to Improve Upper Extremity Function in a Two-year-old Child with Perinatal Stroke: A Case Report.

    Science.gov (United States)

    Musselman, Kristin E; Manns, Patricia; Dawe, Jaclyn; Delgado, Rhina; Yang, Jaynie F

    2018-02-01

    To evaluate the effectiveness and feasibility (i.e. tolerability, adherence) of functional electrical stimulation (FES) for the upper extremity (UE) in a two-year-old child with perinatal stroke. Forty hours of FES over eight weeks was prescribed. FES to the hemiplegic triceps, extensor carpi radialis longus and brevis, extensor carpi ulnaris and extensor digitorum was timed with reaching during play. Assessments were performed before, during, and two months post-intervention. UE function (Melbourne Assessment 2 (MA2), Assisting Hand Assessment (AHA)) and spasticity (Modified Tardieu with electrogoniometry and electromyography) were measured. The mother completed a semi-structured interview post-intervention. Descriptive statistics were used for adherence and UE measures. A repeated-measures ANOVA compared Modified Tardieu parameters (e.g. catch angle) over time. Conventional content analysis was used for the interview data. The child completed 39.2/40 hours. Immediately post-intervention, improvements were observed on MA2's Range of Motion subscale and catch angle (Modified Tardieu, p MA2's Accuracy and Fluency subscales. No change in AHA score occurred. Three themes emerged from the interview: (1) Ingredients for program success; (2) Information about the FES device; and (3) The child's response. UE FES was feasible in a two-year-old child with hemiplegia.

  10. The Work behind Weight-Loss Surgery: A Qualitative Analysis of Food Intake after the First Two Years Post-Op.

    Science.gov (United States)

    Geraci, Angela A; Brunt, Ardith; Marihart, Cindy

    2014-01-01

    Purpose. Obesity has reached epidemic proportions in the U.S. and has nearly doubled worldwide since 1980. Bariatric surgery is on the rise, but little focus has been placed on the psychosocial impacts of surgery. The purpose of this study was to explore experiences of patients who have undergone bariatric surgery at least two years before to gain an understanding of the successes and challenges they have faced since surgery. Methods. This study used a phenomenological approach, to investigate the meaning and essence of bariatric patients with food after surgery. Semi-structured interviews were conducted on a sample of nine participants who had undergone surgery at least two years prior. Findings. Two main themes regarding food intake emerged from the data: (a) food after the first year post-surgery and (b) bariatric surgery is not a magic pill. Upon further analysis, food after the first year post-surgery had four subthemes emerge: diet adherence after the first year post-surgery, food intolerances, amount of food, and tendencies toward coping with food do not magically disappear. Conclusion. Findings revealed that post-operative diet and exercise adherence becomes increasingly difficult as weight loss slows. Many participants find that only after the first year after surgery the work really begins.

  11. Corrosion of metal iron in contact with anoxic clay at 90 °C: Characterization of the corrosion products after two years of interaction

    International Nuclear Information System (INIS)

    Schlegel, Michel L.; Bataillon, Christian; Brucker, Florence; Blanc, Cécile; Prêt, Dimitri; Foy, Eddy; Chorro, Matthieu

    2014-01-01

    Highlights: • Generalized, heterogeneous corrosion is observed. • The corrosion interface is made of several layers with distinct mineralogy. • Magnetite, chukanovite, Fe-phyllosilicate, ankerite are identified from metal to clay. • The estimated corrosion damage (15 μm in two years) supports surface passivation. • The corrosion products contain only half of oxidized Fe. - Abstract: Chemical and mineralogical properties of solids formed upon free corrosion of two iron probes (one massive iron rod, and one model overpack made by two pipes covering the ends of a glass rod) in saturated clay rock (Callovo-Oxfordian formation, East of Paris Basin, France) at 90 °C over two years were investigated by microscopic and spectroscopic techniques (X-ray tomography, scanning electron microscopy coupled with energy-dispersive X-ray analysis, Raman microspectroscopy, micro-X-ray diffraction, and micro-X-ray Absorption Fine Structure spectroscopy). The corrosion rate of the massive rod was monitored in situ by electrochemical impedance spectrometry, and found to decrease from about 90 μm/year during the first month of reaction, to less than 1 μm/year after two years. X-ray tomography revealed the presence of several fractures suggesting the presence of preferential flow and diffusion pathways along the iron samples. Microscopic observations revealed similar corrosion interfaces for both samples. Corrosion heterogeneously affected the interface, with damaged thickness from ∼0 to 80 μm. In extensively damaged areas, an inner discontinuous layer of magnetite in contact with metal, an intermediate chukanovite (Fe 2 CO 3 (OH) 2 ) layer (only when magnetite is present, and only for the overpack), and an outer layer of poorly ordered Fe phyllosilicate were observed. In areas with little damage, only the Fe-silicate solids are observed. The clay transformation layer is predominantly made of ankerite ((Fe,Ca,Mg)CO 3 ) forming a massive unit near the trace of the original

  12. Effectiveness of Standardized Nursing Care Plans in Health Outcomes in Patients with Type 2 Diabetes Mellitus: A Two-Year Prospective Follow-Up Study

    Science.gov (United States)

    Cárdenas-Valladolid, Juan; Salinero-Fort, Miguel A.; Gómez-Campelo, Paloma; de Burgos-Lunar, Carmen; Abánades-Herranz, Juan C.; Arnal-Selfa, Rosa; Andrés, Ana López-

    2012-01-01

    Background Implementation of a standardized language in Nursing Care Plans (SNCP) allows for increased efficiency in nursing data management. However, the potential relationship with patientś health outcomes remains uncertain. The aim of this study was to evaluate the effectiveness of SNCP implementation, based on North American Nursing Diagnosis Association (NANDA) and Nursing Interventions Classification (NIC), in the improvement of metabolic, weight, and blood pressure control of Type 2 Diabetes Mellitus (T2DM) patients. Methods A two-year prospective follow-up study, in routine clinical practice conditions. 31 primary health care centers (Spain) participated with 24,124 T2DM outpatients. Data was collected from Computerized Clinical Records; SNCP were identified using NANDA and NIC taxonomies. Descriptive and ANCOVA analyses were conducted. Results 18,320 patients were identified in the Usual Nursing Care (UNC) group and 5,168 in the SNCP group. At the two-year follow-up, the SNCP group improved all parameters except LDL cholesterol and diastolic blood pressure. We analyzed data adjustming by the baseline value for these variables and variables with statistically significant differences between groups at baseline visit. Results indicated a lowering of all parameters except HbA1c, but a statistically significant reduction was only observed with diastolic blood pressure results. However, the adjusted reduction of diastolic blood pressure is of little clinical relevance. Greater differences of control values for diastolic blood pressure, HbA1c, LDL-cholesterol and Body Mass Index were found in the SNCP group, but only reached statistical significance for HbA1c. A greater proportion of patients with baseline HbA1c ≥7 decreased to <7% at the two-year follow-up in the SNCP group than in the UNC group (16.9% vs. 15%; respectively; p = 0.01). Conclusions Utilization of SNCP was helpful in achieving glycemic control targets in poorly controlled patients with T2DM

  13. Task shifting to non-physician clinicians for integrated management of hypertension and diabetes in rural Cameroon: a programme assessment at two years

    Directory of Open Access Journals (Sweden)

    Grimm Jean-Jacques

    2010-12-01

    Full Text Available Abstract Background The burden of non-communicable chronic diseases, such as hypertension and diabetes, increases in sub-Saharan Africa. However, the majority of the rural population does still not have access to adequate care. The objective of this study is to examine the effectiveness of integrating care for hypertension and type 2 diabetes by task shifting to non-physician clinician (NPC facilities in eight rural health districts in Cameroon. Methods Of the 75 NPC facilities in the area, 69 (87% received basic equipment and training in hypertension and diabetes care. Effectiveness was assessed after two years on status of equipment, knowledge among trained NPCs, number of newly detected patients, retention of patients under care, treatment cost to patients and changes in blood pressure (BP and fasting plasma glucose (FPG among treated patients. Results Two years into the programme, of 54 facilities (78% available for re-assessment, all possessed a functional sphygmomanometer and stethoscope (65% at baseline; 96% stocked antihypertensive drugs (27% at baseline; 70% possessed a functional glucose meter and 72% stocked oral anti-diabetics (15% and 12% at baseline. NPCs' performance on multiple-choice questions of the knowledge-test was significantly improved. During a period of two years, trained NPCs initiated treatment for 796 patients with hypertension and/or diabetes. The retention of treated patients at one year was 18.1%. Hypertensive and diabetic patients paid a median monthly amount of 1.4 and 0.7 Euro respectively for their medication. Among hypertensive patients with ≥ 2 documented visits (n = 493, systolic BP decreased by 22.8 mmHg (95% CI: -20.6 to -24.9; p Conclusions The integration of hypertension and diabetes into primary health care of NPC facilities in rural Cameroon was feasible in terms of equipment and training, accessible in terms of treatment cost and showed promising BP- and FPG-trends. However, low case-detection rates

  14. Task shifting to non-physician clinicians for integrated management of hypertension and diabetes in rural Cameroon: a programme assessment at two years.

    Science.gov (United States)

    Labhardt, Niklaus D; Balo, Jean-Richard; Ndam, Mama; Grimm, Jean-Jacques; Manga, Engelbert

    2010-12-14

    The burden of non-communicable chronic diseases, such as hypertension and diabetes, increases in sub-Saharan Africa. However, the majority of the rural population does still not have access to adequate care. The objective of this study is to examine the effectiveness of integrating care for hypertension and type 2 diabetes by task shifting to non-physician clinician (NPC) facilities in eight rural health districts in Cameroon. Of the 75 NPC facilities in the area, 69 (87%) received basic equipment and training in hypertension and diabetes care. Effectiveness was assessed after two years on status of equipment, knowledge among trained NPCs, number of newly detected patients, retention of patients under care, treatment cost to patients and changes in blood pressure (BP) and fasting plasma glucose (FPG) among treated patients. Two years into the programme, of 54 facilities (78%) available for re-assessment, all possessed a functional sphygmomanometer and stethoscope (65% at baseline); 96% stocked antihypertensive drugs (27% at baseline); 70% possessed a functional glucose meter and 72% stocked oral anti-diabetics (15% and 12% at baseline). NPCs' performance on multiple-choice questions of the knowledge-test was significantly improved. During a period of two years, trained NPCs initiated treatment for 796 patients with hypertension and/or diabetes. The retention of treated patients at one year was 18.1%. Hypertensive and diabetic patients paid a median monthly amount of 1.4 and 0.7 Euro respectively for their medication. Among hypertensive patients with ≥ 2 documented visits (n = 493), systolic BP decreased by 22.8 mmHg (95% CI: -20.6 to -24.9; p < 0.0001) and diastolic BP by 12.4 mmHg (-10.9 to -13.9; p < 0.0001). Among diabetic patients (n = 79) FPG decreased by 3.4 mmol/l (-2.3 to -4.5; p < 0.001). The integration of hypertension and diabetes into primary health care of NPC facilities in rural Cameroon was feasible in terms of equipment and training, accessible in

  15. Stabilisation of sagittal split advancement osteotomies with miniplates: a prospective, multicentre study with two-year follow-up. Part I. Clinical parameters.

    NARCIS (Netherlands)

    Borstlap, W.A.; Stoelinga, P.J.W.; Hoppenreijs, T.J.M.; Hof, M.A. van 't

    2004-01-01

    The principal aim of this study was to assess the postoperative stability of bilateral sagittal split osteotomies (BSSO) using two miniplates. Part I reports on the clinical results including treatment characteristics, nerve functions, TMJ function, occlusional relapse and patient satisfaction. This

  16. The effect of five years versus two years of specialised assertive intervention for first episode psychosis - OPUS II: study protocol for a randomized controlled trial

    DEFF Research Database (Denmark)

    Melau, Marianne; Jeppesen, Pia; Thorup, Anne

    2011-01-01

    . Based on our sample size estimation, 400 patients treated in OPUS for two years will be randomized to further three years of OPUS treatment versus standard treatment. The specialized assertive OPUS treatment consists of three core elements: assertive community treatment, psycho-educational family...... treatment, and social skills training. Discussion It has been hypothesized that there is a critical period from onset up to five years, which represents a window of opportunity where a long-term course can be influenced. Extending the specialized assertive OPUS treatment up to five years may allow...... the beneficial effects to continue beyond the high-risk period, through consolidation of improved social and functional outcome. Trial registration Clinical Trial.gov NCT00914238...

  17. Spatial and temporal patterns of pig herds diagnosed with Postweaning Multisystemic Wasting Syndrome (PMWS) during the first two years of its occurrence in Denmark

    DEFF Research Database (Denmark)

    Vigre, Håkan; Bækbo, P.; Jorsal, Sven Erik Lind

    2005-01-01

    two years after the first herd was diagnosed, and we tested for spatial and spatio-temporal clustering using scan statistics. The study population consisted of pig herds that during the study period (October 2001 - September 2003) performed diagnostic submissions to the two major veterinary diagnostic......The clinical syndrome Postweaning Multisystemic Wasting Syndrome (PMWS) in pigs has emerged globally during the last decade. In October 2001, the first pig herd diagnosed with PMWS was reported in Denmark, and since then the number of herds diagnosed with PMWS has increased markedly. The etiology...... laboratories in Denmark (6724 herds). Of these, 277 herds were diagnosed with PMWS. Two statistically significant spatial clusters of herds diagnosed with PMWS were identified. These clusters included 11% and 8% of the study herds, respectively. Within these two clusters the relative risk for a herd...

  18. An Early Warning System Based on Syndromic Surveillance to Detect Potential Health Emergencies among Migrants: Results of a Two-Year Experience in Italy

    Directory of Open Access Journals (Sweden)

    Christian Napoli

    2014-08-01

    Full Text Available Profound geopolitical changes have impacted the southern and eastern Mediterranean since 2010 and defined a context of instability that is still affecting several countries today. Insecurity combined with the reduction of border controls has led to major population movements in the region and to migration surges from affected countries to southern Europe, especially to Italy. To respond to the humanitarian emergency triggered by this migration surge, Italy implemented a syndromic surveillance system in order to rapidly detect potential public health emergencies in immigrant reception centres. This system was discontinued after two years. This paper presents the results of this experience detailing its strengths and weaknesses in order to document the applicability and usefulness of syndromic surveillance in this specific context.

  19. Short bowel patients treated for two years with glucagon-like peptide 2 (GLP-2): compliance, safety, and effects on quality of life

    DEFF Research Database (Denmark)

    Jeppesen, P B; Lund, P; Gottschalck, I B

    2009-01-01

    BACKGROUND AND AIMS: Glucagon-like peptide 2 (GLP-2) has been shown to improve intestinal absorption in short bowel syndrome (SBS) patients in a short-term study. This study describes safety, compliance, and changes in quality of life in 11 SBS patients at baseline, week 13, 26, and 52 during two...... years of subcutaneous GLP-2 treatment, 400 microgram TID, intermitted by an 8-week washout period. METHODS: Safety and compliance was evaluated during the admissions. The Sickness Impact Profile (SIP), Short Form 36 (SF 36), and Inflammatory Bowel Disease Questionnaire (IBDQ) evaluated quality of life......-ascendo-anastomosis. The investigator excluded a patient due to unreliable feedback. Stoma nipple enlargement was seen in all 9 jejunostomy patients. Reported GLP-2 compliance was excellent (>93%). GLP-2 improved the overall quality of life VAS-score (4.1 +/- 2.8 cm versus 6.0 +/- 2.4 cm, P

  20. Cognition, Emotion and Behavior in Children with Tourette's Syndrome and Children with ADHD-Combined Subtype-A Two-Year Follow-Up Study

    DEFF Research Database (Denmark)

    Hovik, Kjell Tore; Plessen, Kerstin J; Cavanna, Andrea E

    2015-01-01

    OBJECTIVE: This two-year follow-up study investigates the course of and association among measures of cognitive control, focused attention, decision-making and symptom severity (anxiety, depression and behavior) in children and adolescents with Tourette's Syndrome (TS) or Attention...... at T1 and T2. In the decision-making task, the children with TS (with or without comorbidities) preferred a safer strategy in selecting advantageous choices than the children with ADHD-C and the TDC at T2. Children with TS and children with ADHD-C showed higher symptoms of anxiety and depression...... and more problems with emotional control compared with TDC at both time points. Finally, children with ADHD-C self-reported more depression symptoms than those with TS at both assessments. For the TS group, safer decision-making was related to better emotional control, and this relationship was stronger...

  1. No difference in self reported health among coalminers in two different shift schedules at Spitsbergen, Norway, a two years follow-up.

    Science.gov (United States)

    Hanoa, Rolf; Baste, Valborg; Kooij, Arne; Sommervold, Linda; Moen, Bente Elisabeth

    2011-01-01

    This study was performed among coal miners in the remote location Svea, Spitsbergen. The shift schedule used to be 7 d on and 7 d off. The aim of this study was to investigate possible changes in health after a voluntary implementation of a new shift schedule, with periods of 14 d on and 14 d off, for 74 percent of the workers in 2007. A questionnaire was distributed to all employees before and two times after the new shift schedule, comprising questions on type of work, shift schedule, pain, sleep, stress and coping. Ninety nine percent of the employees responded; 274 in 2006, 307 in 2007 and 312 in 2008. Work neither in the 14/14 shift nor 7/7 shift was related to any change in the health after these two years. The coping index for workers in the 14/14 shift improved.

  2. A two year study of norm levels in the facilities of a major Malaysian oil and gas exploration and production company

    International Nuclear Information System (INIS)

    Bradley, D.A.

    1996-01-01

    Four comprehensive surveys of offshore and onshore facilities of a major Malaysian Oil and Gas E and P Company have been completed in the two year period since March 1993. Data include measurements of external gamma dose rate, space contamination, Rn and In progeny levels, particulate radioactivity in ambient air and radium in liquid effluent and sludge. Monitored quantities have yielded values which are for the most part in accord with those of undisturbed environments although limited occurrence of elevation of dose rate, and of radium concentration in sludge have been observed. In the latter instance measured concentrations of 226 Ra and 228 Ac have been within values of less than 1 Bq g -1 , being in general very much less than this. Comparison with reported oil and gas facility NORM levels in other parts of the world indicate present levels to be relatively low. (author)

  3. A study of the validity of urinary tract infection diagnosis in children younger than two years of age at Hvidovre Hospital

    DEFF Research Database (Denmark)

    Roed-Petersen, Casper; Møller, Alice Friis; Høgh, Birthe

    2008-01-01

    INTRODUCTION: The aim of this study is to validate the diagnosis of urinary tract infection (UTI) concerning false-positive diagnoses in children younger than two years of age at Hvidovre Hospital. MATERIALS AND METHODS: The material consists of 89 children (50 girls and 39 boys) diagnosed...... with acute pyelonephritis from September 2002 until October 2004. Two patients dropped out as they were diagnosed in other countries. The patient records were investigated to identify the children who fulfilled the UTI criteria used in the department: 1) Two mid-stream urine samples with bacterial growth...... of = 10.000 cfu (colony forming units)/cc, 2) growth of = 100 cfu/cc in urine obtained by a suprapubic puncture of the bladder or 3) a mid-stream urine sample with bacterial growth of = 10.000 cfu/cc and a clinical picture of UTI together with elevated inflammatory laboratory parameters. RESULTS: 70 out...

  4. Headache: an important factor associated with muscle soreness/pain at the two-year follow-up point among patients with major depressive disorder.

    Science.gov (United States)

    Hung, Ching-I; Liu, Chia-Yih; Yang, Ching-Hui; Wang, Shuu-Jiun

    2016-01-01

    No study has compared the associations of headache, anxiety, and depression at baseline with muscle soreness or pain (MS/P) at baseline and at the two-year follow-up point among outpatients with major depressive disorder (MDD). This study aimed to investigate the above issue. This study enrolled 155 outpatients with MDD at baseline, and 131 attended a two-year follow-up appointment. At baseline, migraine was diagnosed based on the International Classification of Headache Disorders, 2(nd) edition. MDD and anxiety disorders were diagnosed using the Structured Clinical Interview for DSM-IV-TR. The visual analog scale was used to evaluate the intensities of headache and MS/P in the neck, shoulder, back, upper limbs, and lower limbs. Depression and anxiety were evaluated using the Hospital Anxiety and Depression Scale. Multiple linear regressions were used to compare the associations of these factors with MS/P. Compared with anxiety disorders, migraine was more strongly associated with MS/P in all areas at baseline and in the upper and lower limbs at follow-up. Headache intensity at baseline was the factor most strongly associated with MS/P in all areas at baseline and follow-up after controlling for depression and anxiety. Headache intensity at baseline predicted MS/P at baseline and follow-up. Migraine and headache intensity are important factors related to MS/P at baseline and follow-up among patients with MDD. Integrating depression and headache treatment might be indicated to improve MS/P.

  5. Are comorbid anxiety disorders a risk factor for suicide attempts in patients with mood disorders? A two-year prospective study.

    Science.gov (United States)

    Abreu, L N; Oquendo, M A; Galfavy, H; Burke, A; Grunebaum, M F; Sher, L; Sullivan, G M; Sublette, M E; Mann, J; Lafer, B

    2018-01-01

    Comorbid anxiety disorders have been considered a risk factor for suicidal behavior in patients with mood disorders, although results are controversial. The aim of this two-year prospective study was to determine if lifetime and current comorbid anxiety disorders at baseline were risk factors for suicide attempts during the two-year follow-up. We evaluated 667 patients with mood disorders (504 with major depression and 167 with bipolar disorder) divided in two groups: those with lifetime comorbid anxiety disorders (n=229) and those without (n=438). Assessments were performed at baseline and at 3, 12, and 24 months. Kaplan-Meier survival analysis and log-rank test were used to evaluate the relationship between anxiety disorders and suicide attempts. Cox proportional hazard regression was performed to investigate clinical and demographic variables that were associated with suicide attempts during follow-up. Of the initial sample of 667 patients, 480 had all three follow-up interviews. During the follow-up, 63 patients (13.1%) attempted suicide at least once. There was no significant difference in survival curves for patients with and without comorbid anxiety disorders (log-rank test=0.269; P=0.604). Female gender (HR=3.66, P=0.001), previous suicide attempts (HR=3.27, P=0.001) and higher scores in the Buss-Durkee Hostility Inventory (HR=1.05, P≤0.001) were associated with future suicide attempts. Our results suggest that comorbid anxiety disorders were not risk factors for suicide attempts. Further studies were needed to determine the role of anxiety disorders as risk factors for suicide attempts. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  6. Parenting style and family type, but not child temperament, are associated with television viewing time in children at two years of age.

    Science.gov (United States)

    Howe, Anna S; Heath, Anne-Louise M; Lawrence, Julie; Galland, Barbara C; Gray, Andrew R; Taylor, Barry J; Sayers, Rachel; Taylor, Rachael W

    2017-01-01

    Despite the American Academy of Pediatrics (AAP) recommending that electronic media be avoided in children under two years of age, screen use is common in infants and toddlers. The aims of this study were to determine how parenting style, infant temperament, and family type are associated with television viewing in two-year-old children. Participants were from the Prevention of Overweight in Infancy (POI) randomized controlled trial (n = 802) (Dunedin, New Zealand). Demographic information was collected at baseline (late pregnancy), and television and other screen time assessed by questionnaire at 24 months of age. Parenting style (Parenting Practices Questionnaire), infant temperament (Colorado Childhood Temperament Inventory), and family type (7 categories) were reported by both parents. Data were available for 487 participants (61% of the original participants). Median television viewing was relatively low at 21 minutes per day, or 30 minutes in those watching television (82%). Children who watched television played with mobile phones (12% of children) or iPads/tablets (22% of children) more frequently than children who did not (6% of children). In terms of parenting style, children of more authoritarian mothers (β = 17, 95% CI: 6-27 minutes), more authoritarian partners (β = 14, 95% CI: 2-26 minutes), or more permissive mothers (β = 10, 95% CI: 3-17 minutes) watched significantly more television. No significant relationships were observed between child temperament and time watching television after adjustment for confounding variables. Children from "active" families (as rated by partners) watched 29 minutes less television each day (P = 0.002). Parenting style and family type were associated with television viewing time in young children, whereas child temperament was not.

  7. Comparison of Bayesian network and support vector machine models for two-year survival prediction in lung cancer patients treated with radiotherapy

    International Nuclear Information System (INIS)

    Jayasurya, K.; Fung, G.; Yu, S.; Dehing-Oberije, C.; De Ruysscher, D.; Hope, A.; De Neve, W.; Lievens, Y.; Lambin, P.; Dekker, A. L. A. J.

    2010-01-01

    Purpose: Classic statistical and machine learning models such as support vector machines (SVMs) can be used to predict cancer outcome, but often only perform well if all the input variables are known, which is unlikely in the medical domain. Bayesian network (BN) models have a natural ability to reason under uncertainty and might handle missing data better. In this study, the authors hypothesize that a BN model can predict two-year survival in non-small cell lung cancer (NSCLC) patients as accurately as SVM, but will predict survival more accurately when data are missing. Methods: A BN and SVM model were trained on 322 inoperable NSCLC patients treated with radiotherapy from Maastricht and validated in three independent data sets of 35, 47, and 33 patients from Ghent, Leuven, and Toronto. Missing variables occurred in the data set with only 37, 28, and 24 patients having a complete data set. Results: The BN model structure and parameter learning identified gross tumor volume size, performance status, and number of positive lymph nodes on a PET as prognostic factors for two-year survival. When validated in the full validation set of Ghent, Leuven, and Toronto, the BN model had an AUC of 0.77, 0.72, and 0.70, respectively. A SVM model based on the same variables had an overall worse performance (AUC 0.71, 0.68, and 0.69) especially in the Ghent set, which had the highest percentage of missing the important GTV size data. When only patients with complete data sets were considered, the BN and SVM model performed more alike. Conclusions: Within the limitations of this study, the hypothesis is supported that BN models are better at handling missing data than SVM models and are therefore more suitable for the medical domain. Future works have to focus on improving the BN performance by including more patients, more variables, and more diversity.

  8. Effectiveness of mental health first aid training in Sweden. A randomized controlled trial with a six-month and two-year follow-up.

    Science.gov (United States)

    Svensson, Bengt; Hansson, Lars

    2014-01-01

    According to a recent report from the European Brain Council and the European Colleague of Neuropsychopharmacology the one year prevalence of some kind of mental disorder is around 27% among the adult population in Europe. Research has shown a lack of mental health literacy in the population in general and it is thus important to find ways to improve the public's knowledge and skills to provide first hand support to people with mental disorders. Mental Health First Aid (MHFA) is a training program that has shown positive changes in knowledge and helping behavior. This study investigates if MHFA training in a Swedish context provides a sustained improvement in knowledge about mental disorders, a better ability to be helpful in contacts with people who are ill and if it changes attitudes in a positive direction. The introduction of the training program was made in accordance with the constructor's instructions. Participants were mainly public sector employees from a county in the west of Sweden. The study was a randomized controlled trial with an experiment group (n = 199) and a control group (n = 207) placed on a waiting list during a 6-month follow-up. A two-year follow-up was conducted for participants (n = 155) from both the intervention and waiting list group who had completed the training and during the follow-up been in contact with persons with mental disorders. The intervention group improved in knowledge as well as in confidence in providing help for someone in need. The two-year follow-up showed that the improvements were to a great extent maintained. Mental Health First Aid might raise the level of awareness of mental disorders and have an influence on the number of people who can receive professional treatment for their problems.

  9. Cognition, Emotion and Behavior in Children with Tourette's Syndrome and Children with ADHD-Combined Subtype-A Two-Year Follow-Up Study.

    Directory of Open Access Journals (Sweden)

    Kjell Tore Hovik

    Full Text Available This two-year follow-up study investigates the course of and association among measures of cognitive control, focused attention, decision-making and symptom severity (anxiety, depression and behavior in children and adolescents with Tourette's Syndrome (TS or Attention-Deficit/Hyperactivity Disorder-Combined subtype (ADHD-C.19 children with TS, 33 with ADHD-C, and 50 typically developing children (TDC were examined with a battery of psychometric measures and rating forms at baseline and two-years later.All three groups improved likewise in measures of cognitive control over time, whereas only the TDC improved in focused attention. The group of children with TS with comorbidities performed more similar to the children with ADHD-C in cognitive control at T1 and T2, whereas the children with TS without comorbidities performed more similar to the TDC in cognitive control at T1 and T2. In the decision-making task, the children with TS (with or without comorbidities preferred a safer strategy in selecting advantageous choices than the children with ADHD-C and the TDC at T2. Children with TS and children with ADHD-C showed higher symptoms of anxiety and depression and more problems with emotional control compared with TDC at both time points. Finally, children with ADHD-C self-reported more depression symptoms than those with TS at both assessments. For the TS group, safer decision-making was related to better emotional control, and this relationship was stronger for the TS subgroup without comorbidities.This study emphasizes the importance of addressing symptoms of anxiety and depression in children with TS or ADHD-C, identifying the effect of comorbidities in children with TS, and that children with TS or ADHD-C likely differ in their sensitivity to reinforcement contingencies.

  10. Effectiveness of mental health first aid training in Sweden. A randomized controlled trial with a six-month and two-year follow-up.

    Directory of Open Access Journals (Sweden)

    Bengt Svensson

    Full Text Available According to a recent report from the European Brain Council and the European Colleague of Neuropsychopharmacology the one year prevalence of some kind of mental disorder is around 27% among the adult population in Europe. Research has shown a lack of mental health literacy in the population in general and it is thus important to find ways to improve the public's knowledge and skills to provide first hand support to people with mental disorders. Mental Health First Aid (MHFA is a training program that has shown positive changes in knowledge and helping behavior. This study investigates if MHFA training in a Swedish context provides a sustained improvement in knowledge about mental disorders, a better ability to be helpful in contacts with people who are ill and if it changes attitudes in a positive direction.The introduction of the training program was made in accordance with the constructor's instructions. Participants were mainly public sector employees from a county in the west of Sweden. The study was a randomized controlled trial with an experiment group (n = 199 and a control group (n = 207 placed on a waiting list during a 6-month follow-up. A two-year follow-up was conducted for participants (n = 155 from both the intervention and waiting list group who had completed the training and during the follow-up been in contact with persons with mental disorders. The intervention group improved in knowledge as well as in confidence in providing help for someone in need. The two-year follow-up showed that the improvements were to a great extent maintained.Mental Health First Aid might raise the level of awareness of mental disorders and have an influence on the number of people who can receive professional treatment for their problems.

  11. The effect of nitisinone on homogentisic acid and tyrosine: a two-year survey of patients attending the National Alkaptonuria Centre, Liverpool.

    Science.gov (United States)

    Milan, Anna M; Hughes, Andrew T; Davison, Andrew S; Devine, Jean; Usher, Jeannette; Curtis, Sarah; Khedr, Milad; Gallagher, James A; Ranganath, Lakshminarayan R

    2017-05-01

    Background Alkaptonuria is a rare, debilitating autosomal recessive disorder affecting tyrosine metabolism. Deficiency of homogentisate 1,2-dioxygenase leads to increased homogentisic acid which is deposited as ochronotic pigment. Clinical sequelae include severe early onset osteoarthritis, increased renal and prostate stone formation and cardiac complications. Treatment has been largely based on analgaesia and arthroplasty. The National Alkaptonuria Centre in Liverpool has been using 2 mg nitisinone (NTBC) off-license for all patients in the United Kingdom with alkaptonuria and monitoring the tyrosine metabolite profiles. Methods Patients with confirmed alkaptonuria are commenced on 2 mg dose (alternative days) of NTBC for three months with daily dose thereafter. Metabolite measurement by LC-MS/MS is performed at baseline, day 4, three-months, six-months and one-year post-commencing NTBC. Thereafter, monitoring and clinical assessments are performed annually. Results Urine homogentisic acid concentration decreased from a mean baseline 20,557 µmol/24 h (95th percentile confidence interval 18,446-22,669 µmol/24 h) by on average 95.4% by six months, 94.8% at one year and 94.1% at two year monitoring. A concurrent reduction in serum homogentisic acid concentration of 83.2% compared to baseline was also measured. Serum tyrosine increased from normal adult reference interval to a mean ± SD of 594 ± 184 µmol /L at year-two monitoring with an increased urinary excretion from 103 ± 81 µmol /24 h at baseline to 1071 ± 726 µmol /24 h two years from therapy. Conclusions The data presented represent the first longitudinal survey of NTBC use in an NHS service setting and demonstrate the sustained effect of NTBC on the tyrosine metabolite profile.

  12. Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2: Effects on Intestinal Morphology and Absorption, Renal Function, Bone and Body Composition, and Muscle Function

    Directory of Open Access Journals (Sweden)

    P. B. Jeppesen

    2009-01-01

    Full Text Available Background and aims. In a short-term study, Glucagon-like peptide 2 (GLP-2 has been shown to improve intestinal absorption in short bowel syndrome (SBS patients. This study describes longitudinal changes in relation to GLP-2 treatment for two years. Methods. GLP-2, 400 micrograms, s.c.,TID, were offered, to eleven SBS patients keeping parenteral support constant. 72-hour nutritional balance studies were performed at baseline, weeks 13, 26, 52 during two years intermitted by an 8-week washout period. In addition, mucosal morphometrics, renal function (by creatinine clearance, body composition and bone mineral density (by DEXA, biochemical markers of bone turnover (by s-CTX and osteocalcin, PTH and vitamin D, and muscle function (NMR, lungfunction, exercise test were measured. Results. GLP-2 compliance was >93%. Three of eleven patients did not complete the study. In the remaining 8 patients, GLP-2 significantly reduced the fecal wet weight from approximately 3.0 to approximately 2.0 kg/day. This was accompanied by a decline in the oral wet weight intake, maintaining intestinal wet weight absorption and urinary weight constant. Renal function improved. No significant changes were demonstrated in energy intake or absorption, and GLP-2 did not significantly affect mucosal morphology, body composition, bone mineral density or muscle function. Conclusions. GLP-2 treatment reduces fecal weight by approximately 1000 g/d and enables SBS patients to maintain their intestinal fluid and electrolyte absorption at lower oral intakes. This was accompanied by a 28% improvement in creatinine clearance.

  13. Differential movement patterns of juvenile Tengmalms owls (Aegolius funereus during the post-fledging dependence period in two years with contrasting prey abundance.

    Directory of Open Access Journals (Sweden)

    Marek Kouba

    Full Text Available Fledgling behaviour and movement patterns throughout the post-fledging dependence period (PFDP, especially in relation to changing environmental conditions, have been rarely studied, despite the fact that this period is recognized as of crucial significance in terms of high mortality of juveniles. The PFDP can extend over quite a protracted period, particularly in birds of prey, and a knowledge of the movement patterns of individuals is fundamental for understanding mechanisms underlying survival, habitat use and dispersion. We radiotracked 39 fledglings of the Tengmalm's owl (Aegolius funereus in two years with different availability of prey: 2010 (n = 29 and 2011 (n = 10 and obtained 1455 daily locations. Fledglings reached independence on average in 45 days after fledging in 2010 (n = 22 and 57 days in 2011 (n = 6. Within years, the most important measures influencing the distance moved from the nest box were age of fledglings and number of surviving siblings present. Individual home range size and duration of PFDP in particular were dependent on maximal number of siblings seen outside the nest box. In the season with low prey availability fledglings were observed at greater distances from the nest box than in the year with higher prey availability (mean distance: 350 m in 2010 and 650 m in 2011 and occupied larger home ranges (mean: 30.3 ha in 2010 and 57.7 ha in 2011. The main factor causing these differences between years was probably the different availability of prey in these two years, affecting breeding success and post-fledging survivorship of the Tengmalm's owls.

  14. Occurrence and persistence of organic emerging contaminants and priority pollutants in five sewage treatment plants of Spain: Two years pilot survey monitoring

    International Nuclear Information System (INIS)

    Bueno, M.J. Martínez; Gomez, M.J.; Herrera, S.; Hernando, M.D.; Agüera, A.

    2012-01-01

    This work summarized all results obtained during almost two-years of a monitoring programme carried out in five municipal sewage treatment plants (STPs) located in the north, centre and south-east of Spain. The study evaluated the occurrence and persistence of a group of 100 organic compounds belonging to several chemical groups (pharmaceuticals, personal care products, pesticides and metabolites). The average removal efficiencies of the STPs studied varied from 20% (erythromycin) to 99% (acetaminophen). In analysed samples, we identified a large number of compounds at mean range concentrations between 7–59,495 ng/L and 5–32,720 ng/L for influent and effluent samples, respectively. This study also identified 20 of the mostly detected and persistent compounds in wastewater effluent, of which hydrochlorothiazide, atenolol, gemfibrozil, galaxolide and three metabolites (fenofibric acid, 4-AAA and 4-FAA), presented the highest average contribution percentages, in relation to the total load of contaminants for the different STPs effluent studied. Highlights: ► The results summarize two-years of a monitoring programme. ► 100 organic compounds (priority substances and emerging contaminants) were analysed. ► The removal efficiency of 5 STPs of Spain was evaluated. ► The presence of target compounds in treated wastewater was also checked. ► The most frequently drugs detected were: antibiotics< anti-inflammatories<β-blockers. - Antibiotics and analgesics/anti-inflammatories were the most frequently drugs detected, following by some β-blockers, synthetic fragrances, lipid regulators and diuretics.

  15. Two Years of Cinacalcet Hydrochloride Treatment Decreased Parathyroid Gland Volume and Serum Parathyroid Hormone Level in Hemodialysis Patients With Advanced Secondary Hyperparathyroidism.

    Science.gov (United States)

    Yamada, Shunsuke; Tokumoto, Masanori; Taniguchi, Masatomo; Toyonaga, Jiro; Suehiro, Takaichi; Eriguchi, Rieko; Fujimi, Satoru; Ooboshi, Hiroaki; Kitazono, Takanari; Tsuruya, Kazuhiko

    2015-08-01

    The long-term effect of cinacalcet hydrochloride treatment on parathyroid gland (PTG) volume has been scarcely investigated in patients with moderate to advanced secondary hyperparathyroidism (SHPT). The present study was a prospective observational study to determine the effect of cinacalcet treatment on PTG volume and serum biochemical parameters in 60 patients with renal SHPT, already treated with intravenous vitamin D receptor activator (VDRA). Measurement of biochemical parameters and PTG volumes were performed periodically, which were analyzed by stratification into tertiles across the baseline parathyroid hormone (PTH) level or PTG volume. We also determined the factors that can estimate the changes in PTG volume and the achievement of the target PTH range by multivariable analyses. Two years of cinacalcet treatment significantly decreased the serum levels of PTH, calcium, and phosphate, followed by the improvement of achieving the target ranges for these parameters recommended by the Japanese Society for Dialysis Therapy. Cinacalcet decreased the maximal and total PTG volume by about 30%, and also decreased the serum PTH level independent of the baseline serum PTH level and PTG volume. Ten out of 60 patients showed 30% increase in maximal PTG after 2 years. Multivariable analysis showed that patients with nodular PTG at baseline and patients with higher serum calcium and PTH levels at 1 year were likely to exceed the target range of PTH at two years. In conclusion, cinacalcet treatment with intravenous VDRA therapy decreased both PTG volume and serum intact PTH level, irrespective of the pretreatment PTG status and past treatment history. © 2015 The Authors. Therapeutic Apheresis and Dialysis © 2015 International Society for Apheresis.

  16. Human rotavirus vaccine (RIX4414) efficacy in the first two years of life: a randomized, placebo-controlled trial in China.

    Science.gov (United States)

    Li, Rong-cheng; Huang, Teng; Li, Yanping; Luo, Dong; Tao, Junhui; Fu, Botao; Si, Guoai; Nong, Yi; Mo, Zhaojun; Liao, XueYan; Luan, Ivy; Tang, Haiwen; Rathi, Niraj; Karkada, Naveen; Han, Htay Htay

    2014-01-01

    Rotaviruses (RV) are a major cause of severe gastroenteritis (GE) in children agedefficacy of two oral doses of the human rotavirus vaccine (RIX4414) in infants during the first two years of life (113808/NCT01171963). Healthy infants aged 6-16 weeks were randomized (1:1) to receive two oral doses of either the RIX4414 vaccine/placebo according to a 0, 1 month schedule. Vaccine efficacy (VE) against severe RVGE was assessed from two weeks post-Dose 2 up until the end of the second RV season and calculated with its 95% confidence intervals (CI). The primary efficacy objective was met if the lower limit of the 95% CI on VE was ≥10%. Unsolicited symptoms reported during the 31-d post-vaccination follow-up period and serious adverse events (SAEs) reported throughout the study were assessed. Of 3333 enrolled infants, 3148 were included in the according-to-protocol efficacy cohort. Over two consecutive RV seasons, fewer severe RVGE episodes were reported in the RIX4414 group (n=21) vs. the placebo group (n=75). VE against severe RVGE was 72% (95% CI: 54.1-83.6); the lower limit of the 95% CI on VE was >10%. The number of unsolicited symptoms and SAEs reported was similar between both groups. Thirteen deaths (RIX4414=6; placebo=7) occurred during the study. All SAEs and deaths in the RIX4414 group were considered unrelated to vaccination. Two oral doses of RIX4414 vaccine provided a substantial level of protection against severe RVGE in Chinese children during the first two years of life.

  17. Two years monitoring of soil N_{2}O emissions on durum wheat in a Mediterranean area: the effect of tillage intensity and N-fertilizer rate.

    Science.gov (United States)

    Volpi, Iride; Bosco, Simona; Triana, Federico; Di Nasso, Nicoletta Nassi o.; Laville, Patricia; Virgili, Giorgio; Bonari, Enrico

    2016-04-01

    Evaluating the magnitude and the key factors affecting N2O emissions from agriculture has a scientific and practical relevance, in fact emissions from agricultural and natural soils account for 56-70% of all global N2O sources (Syakila and Kroeze, 2011). Moreover, the necessity to increase the food production rate minimizing greenhouse gas emissions require a deeper understanding of the effect of the agricultural practices on direct soil emissions. Therefore, the aim of this work is to assess the effect of tillage intensity and nitrogen rate on soil N2O emissions on durum wheat. A two years monitoring campaign was carried out using a high-sensibility transportable instrument developed within the LIFE+ "Improved flux Prototypes for N2O emission from Agriculture" IPNOA project (Bosco et al., 2015; Laville et al., 2015). The project aims at improving the measurement technique of N2O flux directly in field using the flow-through non-steady state chamber technique. The monitoring campaign on durum wheat lasted for two growing seasons and two fallow periods (2013-14 and 2014-15). Treatment on the main plot was tillage intensity with two levels, ploughing and minimum tillage, and three different nitrogen rates were distributed to the subplots (N0: 0 kg ha-1, N1: 110 kg ha-1, N2: 170 kg ha-1). Ancillary measurements concerned meteorological data, soil temperature and moisture, NO3-, NH4+ soil concentration. Main results of the two years highlighted N rate as the main driver for both N2O daily flux and cumulative emissions during the growing season, while in the fallow period treatments did not affect the emission magnitude. Tillage intensity was not a key factor for N2O emissions. N2O emissions were significantly different in the two years. In particular, cumulative emissions of 2013-14 were about five times higher than in 2014-15, respectively on average 2885±260 g N-N2O ha-1 and 534±53 g N-N2O ha-1 for a similar monitoring period of about 300 days. Differences could be

  18. Black soiling of an architectural limestone during two-year term exposure to urban air in the city of Granada (S Spain)

    International Nuclear Information System (INIS)

    Urosevic, Maja; Yebra-Rodríguez, Africa; Sebastián-Pardo, Eduardo; Cardell, Carolina

    2012-01-01

    A two-year term aging test was carried out on a building limestone under different urban conditions in the city of Granada (Southern Spain) to assess its Cultural Heritage sustainability. For this purpose stone tablets were placed vertically at four sites with contrasting local pollution micro-environments and exposure conditions (rain-sheltered and unsheltered). The back (rain-sheltered) and the front (rain-unsheltered) faces of the stone tablets were studied for each site. The soiling process (surface blackening) was monitored through lightness (ΔL*) and chroma changes (ΔC*). Additionally atmospheric particles deposited on the stone surfaces and on PM10 filters during the exposure time were studied through a multianalytical approach including scanning electron microscopy (SEM-EDX), transmission electron microscopy (TEM) and micro-Raman spectroscopy. The identified atmospheric particles (responsible for stone soiling) were mainly soot and soil dust particles; also fly ash and aged salt particles were found. The soiling process was related to surface texture, exposure conditions and proximity to dense traffic streets. On the front faces of all stones, black soiling and surface roughness promoted by differential erosion between micritic and sparitic calcite were noticed. Moreover, it was found that surface roughness enhanced a feedback process that triggers further black soiling. The calculated effective area coverage (EAC) by light absorbing dust ranged from 10.2 to 20.4%, exceeding by far the established value of 2% EAC (limit perceptible to the human eye). Soiling coefficients (SC) were estimated based on square-root and bounded exponential fittings. Estimated black carbon (BC) concentration resulted in relatively similar SC for all studied sites and thus predicts the soiling process better than using particulate matter (PM10) concentration. - Highlights: ► A two-year term aging test was carried out on a building limestone under different urban conditions.

  19. Longitudinal proxy measurements in multiple sclerosis: patient-proxy agreement on the impact of MS on daily life over a period of two years

    Directory of Open Access Journals (Sweden)

    Thompson Alan J

    2008-02-01

    Full Text Available Abstract Background The use of self-report measurements in clinical settings is increasing. However, in patients with limitations that interfere with reliable self-assessment such as cognitive impairment or mood disturbances, as may be the case in multiple sclerosis (MS, data collection might be problematic. In these situations, information obtained from proxy respondents (e.g. partners may replace self-ratings. The aim of this study was to examine the value of proxy ratings at separate points in time and to assess patient-proxy agreement on possible changes in disease impact of MS. Methods Fifty-six MS patients and their partners completed the Multiple Sclerosis Impact Scale (MSIS-29 at baseline and follow-up, two years later. Patient-proxy agreement was assessed at both time points by calculating intraclass correlation coefficients (ICCs, exact and global agreement and the mean directional differences between groups. Agreement of change over time was assessed by calculating ICCs between change scores. In parallel, global ratings of both patients and proxy respondents of the extent to which the patient had improved or deteriorated over the past two years were collected to validate possible changes on the MSIS-29. Results At both time points, agreement on the physical scale was higher than agreement on the psychological scale (ICCs at baseline were 0.81 for the physical scale and 0.72 for the psychological scale; at follow-up, the ICC values were 0.86 and 0.65 respectively. At follow-up, statistically significant mean differences between patients and proxies were noted for the physical scale (-4.8 ± 12.7, p = 0.006 and the psychological scale (-8.9 ± 18.8, p = 0.001. Agreement between change scores on the MSIS-29 was fair (ICC Conclusion Proxy respondents could act as a reliable source of information in cross-sectional studies. Moreover, results suggested that agreement on change over time might be better for proxy respondents compared to

  20. Two-year post-discharge costs of care among patients treated with transcatheter or surgical aortic valve replacement in Germany.

    Science.gov (United States)

    Kaier, Klaus; von Kampen, Frederike; Baumbach, Hardy; von Zur Mühlen, Constantin; Hehn, Philip; Vach, Werner; Zehender, Manfred; Bode, Christoph; Reinöhl, Jochen

    2017-07-11

    This study presents data on post-discharge costs of care among patients treated with transcatheter or surgical aortic valve replacement over a two year period. Based on a prospective clinical trial, post-discharge utilization of health services and status of assistance were collected for 151 elderly patients via 2250 monthly telephone interviews, valued using standardized unit costs and analysed using two-part regression models. At month 1 post-discharge, total costs of care are substantially elevated (monthly mean: €3506.7) and then remain relatively stable over the following 23 months (monthly mean: €622.3). As expected, the majority of these costs are related to in-hospital care (~98% in month 1 post-discharge and ~72% in months 2-24). Patients that died during follow-up were associated with substantially higher cost estimates of in-hospital care than those surviving the two-year study period, while patients' age and other patient characteristics were of minor relevance. Estimated costs of outpatient care are lower at month 1 than during the rest of the study period, and not affected by the event of death during follow-up. The estimated costs of nursing care are, in contrast, much higher in year 2 than in year 1 and differ substantially by gender and type of procedure as well as by patients' age. Overall, these monthly cost estimates add up to €10,352 for the first and €7467.6 for the second year post-discharge. Substantial cost increases at month 1 post-discharge and in case of death during follow-up are the main findings of the study, which should be taken into account in future economic evaluations on the topic. Application of standardized unit costs in combination with monthly patient interviews allows for a far more precise estimate of the variability in post-discharge health service utilization in this group of patients than the ones given in previous studies. German Clinical Trial Register Nr. DRKS00000797 .

  1. Nitrous oxide and methane emissions from optimized and alternative cereal cropping systems on the North China Plain: A two-year field study

    International Nuclear Information System (INIS)

    Gao, Bing; Ju, Xiaotang; Su, Fang; Meng, Qingfeng; Oenema, Oene; Christie, Peter; Chen, Xinping; Zhang, Fusuo

    2014-01-01

    The impacts of different crop rotation systems with their corresponding management practices on grain yield, greenhouse gas emissions, and fertilizer nitrogen (N) and irrigation water use efficiencies are not well documented. This holds especially for the North China Plain which provides the staple food for hundreds of millions of people and where groundwater resources are polluted with nitrate and depleted through irrigation. Here, we report on fertilizer N and irrigation water use, grain yields, and nitrous oxide (N 2 O) and methane (CH 4 ) emissions of conventional and optimized winter wheat–summer maize double-cropping systems, and of three alternative cropping systems, namely a winter wheat–summer maize (or soybean)–spring maize system, with three harvests in two years; and a single spring maize system with one crop per year. The results of this two-year study show that the optimized double-cropping system led to a significant increase in grain yields and a significant decrease in fertilizer N use and net greenhouse gas intensity, but the net greenhouse gas N 2 O emissions plus CH 4 uptake and the use of irrigation water did not decrease relative to the conventional system. Compared to the conventional system the net greenhouse gas emissions, net greenhouse gas intensity and use of fertilizer N and irrigation water decreased in the three alternative cropping systems, but at the cost of grain yields except in the winter wheat–summer maize–spring maize system. Net uptake of CH 4 by the soil was little affected by cropping system. Average N 2 O emission factors were only 0.17% for winter wheat and 0.53% for maize. In conclusion, the winter wheat–summer maize–spring maize system has considerable potential to decrease water and N use and decrease N 2 O emissions while maintaining high grain yields and sustainable use of groundwater. - Highlights: • Yields, resource use efficiency and N 2 O + CH 4 emission differ among cropping systems. • An

  2. Nitrous oxide and methane emissions from optimized and alternative cereal cropping systems on the North China Plain: A two-year field study

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Bing [College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193 (China); Ju, Xiaotang, E-mail: juxt@cau.edu.cn [College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193 (China); Su, Fang; Meng, Qingfeng [College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193 (China); Oenema, Oene [Wageningen University and Research, Alterra, Wageningen (Netherlands); Christie, Peter [College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193 (China); Agri-Environment Branch, Agri-Food and Biosciences Institute, Belfast BT9 5PX (United Kingdom); Chen, Xinping; Zhang, Fusuo [College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193 (China)

    2014-02-01

    The impacts of different crop rotation systems with their corresponding management practices on grain yield, greenhouse gas emissions, and fertilizer nitrogen (N) and irrigation water use efficiencies are not well documented. This holds especially for the North China Plain which provides the staple food for hundreds of millions of people and where groundwater resources are polluted with nitrate and depleted through irrigation. Here, we report on fertilizer N and irrigation water use, grain yields, and nitrous oxide (N{sub 2}O) and methane (CH{sub 4}) emissions of conventional and optimized winter wheat–summer maize double-cropping systems, and of three alternative cropping systems, namely a winter wheat–summer maize (or soybean)–spring maize system, with three harvests in two years; and a single spring maize system with one crop per year. The results of this two-year study show that the optimized double-cropping system led to a significant increase in grain yields and a significant decrease in fertilizer N use and net greenhouse gas intensity, but the net greenhouse gas N{sub 2}O emissions plus CH{sub 4} uptake and the use of irrigation water did not decrease relative to the conventional system. Compared to the conventional system the net greenhouse gas emissions, net greenhouse gas intensity and use of fertilizer N and irrigation water decreased in the three alternative cropping systems, but at the cost of grain yields except in the winter wheat–summer maize–spring maize system. Net uptake of CH{sub 4} by the soil was little affected by cropping system. Average N{sub 2}O emission factors were only 0.17% for winter wheat and 0.53% for maize. In conclusion, the winter wheat–summer maize–spring maize system has considerable potential to decrease water and N use and decrease N{sub 2}O emissions while maintaining high grain yields and sustainable use of groundwater. - Highlights: • Yields, resource use efficiency and N{sub 2}O + CH{sub 4} emission

  3. Response of a two-year sugar beet-sweet sorghum rotation to an agronomic management approach diversified by soil tillage and nitrogen fertilisation

    Directory of Open Access Journals (Sweden)

    A. Domenico Palumbo

    2014-08-01

    Full Text Available Conservative agriculture and nitrogen fertilisation have been evaluated for the purpose of assessing their impact on the sustainability of a cropping system based on a two-year rotation with two crops considered for the bio-ethanol supply chain: sugar beet (Beta vulgaris L. subsp. vulgaris and sweet sorghum (Sorghum bicolor L. Moench. The experimental activity started in 2009 in Foggia (Apulia, southern Italy. We discuss the results obtained in the 2010-2011 period. Soil minimum tillage (MT vs no tillage (NT combined with two doses of nitrogen fertilisation (75 and 150 kg ha–1 of mineral nitrogen as ammonium nitrate were compared. The experimental system, which is still operational (soil tillage plus nitrogen fertilisation, was arranged with a split-plot design with three replicates. Treatments were applied on the same plots every year with both crops present at the same time. At the first harvest in 2010, no difference was observed. As to the second year, the comparison between NT vs MT treatments showed that sugar beet had lower total yield (35 vs 42 t ha–1, dry biomass (10 vs 14 t ha–1, and sucrose yield (6.7 vs 8.2 t ha–1. Total soluble solids, on average 19%, were not influenced by the experimental treatments. Nitrogen (N control was less productive than the fertilised treatments (average between N75 and N150 in terms of total fresh root yield (32 vs 42 t ha–1, dry biomass (10 vs 14 t ha–1, and sucrose yield (6.0 vs 8.1 t ha–1. As with sugar beet, during the second year, also sweet sorghum sown in NT vs MT plots had a reduced yield, although the difference was more marked for fresh biomass (–35% than for dry biomass (–20%. No interaction in terms of soil tillage nitrogen fertilisation occurred. In summary, in the first two-year period (2010-2011 of the experimental trial, no tillage soil management showed decreased yields of both crops. Sugar beet displayed a higher sensitivity to the lack of nitrogen supply than sweet

  4. Endotracheal intubation with airtraq® versus storz® videolaryngoscope in children younger than two years - a randomized pilot-study

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    Sørensen Martin

    2012-04-01

    Full Text Available Abstract Background New laryngoscopes have become available for use in small children. The aim of the study was to compare the Storz® videolaryngoscope (SVL to the Airtraq® Optical laryngoscope (AOL for tracheal intubation in children younger than two years of age who had a normal airway assessment. Our hypothesis was that the SVL would have a better success rate than the AOL. Methods Ten children aged 2 years or younger scheduled for elective cleft lip/palate surgery were included. The anesthesia was standardized and a Cormack-Lehane (CL-score was obtained using a Macintosh laryngoscope. After randomization CL-score and endotracheal tube positioning in front of the glottis was performed with one device, followed by the same procedure and intubation with the other device. The video-feed was recorded along with real-time audio. The primary endpoint was the success rate, defined as intubation in first attempt. Secondary endpoints were the time from start of laryngoscopy to CL-score, tube positioning in front of the glottis, and intubation. Results Two intubation attempts were needed in two of five patients randomized to the SVL. The difference in time (SVL vs. AOL to CL-score was 4.5 sec (p = 0.0449. The difference in time (SVL vs. AOL to tube positioning was 11.6 sec (p = 0.0015. Time to intubation was 29.0 sec for SVL and 15.8 sec for AOL. Conclusion No difference in the success rate of endotracheal intubation could be established in this ten patient sample of children younger than two years with a normal airway assessment scheduled for elective cleft lip/palate surgery. However, the Airtraq® Optical videolaryngoscope showed a number of time related advantages over the Storz® videolaryngoscope. Because of the small sample size a larger trial is needed to confirm these findings. Both devices were considered safe in all intubations. Trial registration ClinicalTrials.gov; Identifier NCT01090726.

  5. Antiretroviral treatment for HIV in rural Uganda: two-year treatment outcomes of a prospective health centre/community-based and hospital-based cohort.

    Directory of Open Access Journals (Sweden)

    Walter Kipp

    Full Text Available In sub-Saharan Africa, a shortage of trained health professionals and limited geographical access to health facilities present major barriers to the expansion of antiretroviral therapy (ART. We tested the utility of a health centre (HC/community-based approach in the provision of ART to persons living with HIV in a rural area in western Uganda.The HIV treatment outcomes of the HC/community-based ART program were evaluated and compared with those of an ART program at a best-practice regional hospital. The HC/community-based cohort comprised 185 treatment-naïve patients enrolled in 2006. The hospital cohort comprised of 200 patients enrolled in the same time period. The HC/community-based program involved weekly home visits to patients by community volunteers who were trained to deliver antiretroviral drugs to monitor and support adherence to treatment, and to identify and report adverse reactions and other clinical symptoms. Treatment supporters in the homes also had the responsibility to remind patients to take their drugs regularly. ART treatment outcomes were measured by HIV-1 RNA viral load (VL after two years of treatment. Adherence was determined through weekly pill counts.Successful ART treatment outcomes in the HC/community-based cohort were equivalent to those in the hospital-based cohort after two years of treatment in on-treatment analysis (VL≤400 copies/mL, 93.0% vs. 87.3%, p = 0.12, and in intention-to-treat analysis (VL≤400 copies/mL, 64.9% and 62.0%, p = 0.560. In multivariate analysis patients in the HC/community-based cohort were more likely to have virologic suppression compared to hospital-based patients (adjusted OR = 2.47, 95% CI 1.01-6.04.Acceptable rates of virologic suppression were achieved using existing rural clinic and community resources in a HC/community-based ART program run by clinical officers and supported by lay volunteers and treatment supporters. The results were equivalent to those of a

  6. Motor coordination and visual information processing in high school students at risk of developmental coordination disorder: Two year follow-up study

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    Rudolf Psotta

    2014-03-01

    Full Text Available BACKGROUND: Developmental coordination disorder (DCD in children is characterised by the execution being substantially below that expected given the individual's chronological age. This deficit can negatively affect the psychological and social development of the children and their academic achievements. A few studies provided the evidences on the persistence of impaired motor coordination up to the middle and older adolescence. Although DCD is the heterogeneous syndrome, it seems to be associated with problems in visual information processing. AIMS: The first aim of the study was to examine how a below-average motor coordination in the adolescents can be associated with visual information processing ability. Second aim was to reveal the short-term pathway of impaired motor coordination during adolescence and whether their persistence and reduction, respectively, could be associated with a level of visual information processing. METHODS: In the first phase of the study the below average motor coordination identified by the MABC-2 test (Henderson, Sugden, & Barnett, 2007 in the students of the high and vocational schools (n = 52 was analysed on its relation to the ability of visual information processing. This ability was assessed by the simple and choice reaction tests (FiTRO Reaction Check device. In the 2nd phase of the study the students with moderate and significant motor difficulties (n = 34 were reassessed two years after the initial testing to examine the changes in motor coordination and its potential association with a level of visual information processing. RESULTS: The below-average motor coordination correlated with the several measures of choice reaction with a determination of R2 9-15%, while a level of selective attention and physical growth of the adolescents were not the significant factors of motor skills. Of 34 adolescents 18 students demonstrated the reduction of motor difficulties in two years, and the persistence of the

  7. Black soiling of an architectural limestone during two-year term exposure to urban air in the city of Granada (S Spain)

    Energy Technology Data Exchange (ETDEWEB)

    Urosevic, Maja, E-mail: maja@ugr.es [Dept. Mineralogy and Petrology, Faculty of Science, University of Granada, Campus Fuentenueva s/n, 18071 Granada (Spain); Yebra-Rodriguez, Africa [Dept. Geology-Associated Unit IACT (CSIC-UGR), Faculty of Experimental Science, University of Jaen, Campus Las Lagunillas s/n, 23071 Jaen (Spain); Sebastian-Pardo, Eduardo; Cardell, Carolina [Dept. Mineralogy and Petrology, Faculty of Science, University of Granada, Campus Fuentenueva s/n, 18071 Granada (Spain)

    2012-01-01

    A two-year term aging test was carried out on a building limestone under different urban conditions in the city of Granada (Southern Spain) to assess its Cultural Heritage sustainability. For this purpose stone tablets were placed vertically at four sites with contrasting local pollution micro-environments and exposure conditions (rain-sheltered and unsheltered). The back (rain-sheltered) and the front (rain-unsheltered) faces of the stone tablets were studied for each site. The soiling process (surface blackening) was monitored through lightness ({Delta}L*) and chroma changes ({Delta}C*). Additionally atmospheric particles deposited on the stone surfaces and on PM10 filters during the exposure time were studied through a multianalytical approach including scanning electron microscopy (SEM-EDX), transmission electron microscopy (TEM) and micro-Raman spectroscopy. The identified atmospheric particles (responsible for stone soiling) were mainly soot and soil dust particles; also fly ash and aged salt particles were found. The soiling process was related to surface texture, exposure conditions and proximity to dense traffic streets. On the front faces of all stones, black soiling and surface roughness promoted by differential erosion between micritic and sparitic calcite were noticed. Moreover, it was found that surface roughness enhanced a feedback process that triggers further black soiling. The calculated effective area coverage (EAC) by light absorbing dust ranged from 10.2 to 20.4%, exceeding by far the established value of 2% EAC (limit perceptible to the human eye). Soiling coefficients (SC) were estimated based on square-root and bounded exponential fittings. Estimated black carbon (BC) concentration resulted in relatively similar SC for all studied sites and thus predicts the soiling process better than using particulate matter (PM10) concentration. - Highlights: Black-Right-Pointing-Pointer A two-year term aging test was carried out on a building limestone

  8. The clinical significance and risk factors of anti-platelet factor 4/heparin antibody on maintenance hemodialysis patients: a two-year prospective follow-up.

    Directory of Open Access Journals (Sweden)

    Delong Zhao

    Full Text Available BACKGROUND: Heparin-induced thrombocytopenia is an immune response mediated by anti-PF4/heparin antibody, which is clinically characterized by thrombocytopenia and thromboembolic events. In this study, a prospective and multi-center clinical investigation 1 determined the positive rate of anti-PF4/heparin antibody in maintenance hemodialysis patients in China, 2 identified the related risk factors, and 3 further explored the effect of the anti-PF4/heparin antibody on bleeding, thromboembolic events, and risk of death in the patients. METHODS: The serum anti-PF4/heparin antibody was measured in 661 patients from nine hemodialysis centers, detected by IgG-specific ELISA and followed by confirmation with excess heparin. Risk factors of these patients were analyzed. Based on a two-year follow-up, the association between the anti-PF4/heparin antibody and bleeding, thromboembolic events, and risk of death in the patients was investigated. RESULTS: 1 The positivity rate of the anti-PF4/heparin antibody in maintenance hemodialysis patients was 5.6%. With diabetes as an independent risk factor, the positivity rate of the anti-PF4/heparin antibody decreased in the patients undergoing weekly dialyses ≥3 times. 2 The positivity rate of the anti-PF4/heparin antibody was not related to the occurrence of clinical thromboembolic events and was not a risk factor for death within two years in maintenance hemodialysis patients. 3 Negativity for the anti-PF4/heparin antibody combined with a reduction of the platelet count or combined with the administration of antiplatelet drugs yielded a significant increase in bleeding events. However, the composite determination of the anti-PF4/heparin antibody and thrombocytopenia, as well as the administration of antiplatelet drugs, was not predictive for the risk of thromboembolic events in the maintenance hemodialysis patients. CONCLUSIONS: A single detection of the anti-PF4/heparin antibody did not predict the occurrence

  9. An Intensive Lifestyle Intervention Is an Effective Treatment of Morbid Obesity: The TRAMOMTANA Study—A Two-Year Randomized Controlled Clinical Trial

    Science.gov (United States)

    Burguera, Bartolomé; Jesús Tur, Juan; Escudero, Antonio Jorge; Alos, María; Pagán, Alberto; Cortés, Baltasar; González, Xavier Francesc; Soriano, Joan B.

    2015-01-01

    Bariatric surgery is currently the most effective therapy to induce weight loss in morbidly obese patients. Objective. This controlled, clinical trial with a two-year intervention was aimed at comparing the efficacy of two nonsurgical approaches versus bariatric surgery, on body weight changes and metabolic parameters in morbidly obese patients. Methods. Patients were randomized to an Intensive Lifestyle Intervention (ILI) (n = 60) or Conventional Obesity Therapy (COT) (n = 46). The ILI group received behavioral therapy and nutritional counseling. The COT group received standard medical treatment. They were compared with a third group, Surgical Obesity Group (SOG) (n = 37). Results. Patients who received ILI had a greater percentage of weight loss than patients receiving COT (−11.3% versus −1.6%; p < 0.0044). Interestingly 31.4% of patients included in the ILI group were no longer morbidly obese after just six months of intervention, increasing to 44.4% after 24 months of intervention. The percentage weight loss in SOG was −29.6% after that same period of time. Conclusions. ILI was associated with significant weight loss when compared to COT, in a group of patients with obesity. An ILI approach could be an alternative therapy to patients with obesity, who are not candidates to undergo bariatric surgery. This trial is registered with EudraCT 2009-013737-24. PMID:26257780

  10. An Intensive Lifestyle Intervention Is an Effective Treatment of Morbid Obesity: The TRAMOMTANA Study—A Two-Year Randomized Controlled Clinical Trial

    Directory of Open Access Journals (Sweden)

    Bartolomé Burguera

    2015-01-01

    Full Text Available Bariatric surgery is currently the most effective therapy to induce weight loss in morbidly obese patients. Objective. This controlled, clinical trial with a two-year intervention was aimed at comparing the efficacy of two nonsurgical approaches versus bariatric surgery, on body weight changes and metabolic parameters in morbidly obese patients. Methods. Patients were randomized to an Intensive Lifestyle Intervention (ILI (n=60 or Conventional Obesity Therapy (COT (n=46. The ILI group received behavioral therapy and nutritional counseling. The COT group received standard medical treatment. They were compared with a third group, Surgical Obesity Group (SOG (n=37. Results. Patients who received ILI had a greater percentage of weight loss than patients receiving COT (−11.3% versus −1.6%; p<0.0044. Interestingly 31.4% of patients included in the ILI group were no longer morbidly obese after just six months of intervention, increasing to 44.4% after 24 months of intervention. The percentage weight loss in SOG was −29.6% after that same period of time. Conclusions. ILI was associated with significant weight loss when compared to COT, in a group of patients with obesity. An ILI approach could be an alternative therapy to patients with obesity, who are not candidates to undergo bariatric surgery. This trial is registered with EudraCT 2009-013737-24.

  11. Prevalence and correlates of problematic internet experiences and computer-using time: a two-year longitudinal study in korean school children.

    Science.gov (United States)

    Yang, Su-Jin; Stewart, Robert; Lee, Ju-Yeon; Kim, Jae-Min; Kim, Sung-Wan; Shin, Il-Seon; Yoon, Jin-Sang

    2014-01-01

    To measure the prevalence of and factors associated with online inappropriate sexual exposure, cyber-bullying victimisation, and computer-using time in early adolescence. A two-year, prospective school survey was performed with 1,173 children aged 13 at baseline. Data collected included demographic factors, bullying experience, depression, anxiety, coping strategies, self-esteem, psychopathology, attention-deficit hyperactivity disorder symptoms, and school performance. These factors were investigated in relation to problematic Internet experiences and computer-using time at age 15. The prevalence of online inappropriate sexual exposure, cyber-bullying victimisation, academic-purpose computer overuse, and game-purpose computer overuse was 31.6%, 19.2%, 8.5%, and 21.8%, respectively, at age 15. Having older siblings, more weekly pocket money, depressive symptoms, anxiety symptoms, and passive coping strategy were associated with reported online sexual harassment. Male gender, depressive symptoms, and anxiety symptoms were associated with reported cyber-bullying victimisation. Female gender was associated with academic-purpose computer overuse, while male gender, lower academic level, increased height, and having older siblings were associated with game-purpose computer-overuse. Different environmental and psychological factors predicted different aspects of problematic Internet experiences and computer-using time. This knowledge is important for framing public health interventions to educate adolescents about, and prevent, internet-derived problems.

  12. To assess the relations between breast feeding and illness in children under two years of age with particular reference to respiratory tract infections

    International Nuclear Information System (INIS)

    Javed, N.; Zaidi, N.; Khan, M.A.

    2008-01-01

    The study was carried out to examine the relation between the breast feeding and morbidity as a result of respiratory illness and infection in the children less than two years of age. This is a prospective analysis of 131 children attending the outdoor paediatric department of Federal Government Services Hospital, Islamabad during the month of February 2006. A close ended pretested questionnaire was filled after taking informed consent from patient's parents. Out of total 131 enrolled cases (76 male and 55 female) 62 (47%) were breast fed; 56 (43%) bottle fed; while 13 (10%) had mix feeding. Among 38 children, having past history of respiratory tract infections episodes in last one month, only 04 (10%) were breast fed and remaining 34 (90%) were either bottle fed or had partial breast feeding. Out of 62 breast fed children, only 04 (6%) had recurrent episodes of respiratory tract infections, on the other hand out of 56 bottle fed 32 (57%) had previous history of respiratory illness. In our study there is a significant correlation between breast feeding and reduction in number of Respiratory tact infections episodes. Predominant breast feeding for at leas six months and partial breast feeding for up to one year may reduce the prevalence and subsequent morbidity of respiratory illness and infection in infancy. (author)

  13. A retrospective review comparing two-year patient-reported outcomes, costs, and healthcare resource utilization for TLIF vs. PLF for single-level degenerative spondylolisthesis.

    Science.gov (United States)

    Kim, Elliott; Chotai, Silky; Stonko, David; Wick, Joseph; Sielatycki, Alex; Devin, Clinton J

    2018-03-01

    The purpose of this study was to compare patient-reported outcomes (PROs), morbidity, and costs of TLIF vs PLF to determine whether one treatment was superior in the setting of single-level degenerative spondylolisthesis. Patients undergoing TLIF or PLF for single-level spondylolisthesis were included for retrospective analysis. EQ-5D, ODI, SF-12 MCS/PCS, NRS-BP/LP scores were collected at baseline and 24 months after surgery. 90-day post-operative complications, revision surgery rates, and satisfaction scores were also collected. Two-year resource use was multiplied by unit costs based on Medicare payment amounts (direct cost). Patient and caregiver workday losses were multiplied by the self-reported gross-of-tax wage rate (indirect cost). Total cost was used to assess mean total 2-year cost per QALYs gained after surgery. 62 and 37 patients underwent TLIF and PLF, respectively. Patients in the PLF group were older (p differences were seen in baseline or 24-month PROs between the two groups. There was a significant improvement in all PROs from baseline to 24 months after surgery (p difference in 24-month direct, indirect, and total cost. Overall costs and health care utilization were similar in both the groups. Both TLIF and PLF for single-level degenerative spondylolisthesis provide improvement in disability, pain, quality of life, and general health.

  14. Long-term effects of smoking cessation support in primary care: results of a two-year longitudinal study in Brazil

    Directory of Open Access Journals (Sweden)

    Nádia Cristina Pinheiro Rodrigues

    2016-06-01

    Full Text Available ABSTRACT Objective The objective of this study was to evaluate the long-term effects of a Brazilian smoking cessation support program and the factors that are associated with its success. Methods A longitudinal study was conducted from 2012 to 2014 with 84 patients enrolled in smoking cessation support groups in a Primary Care Center from a poor community in Rio de Janeiro (Brazil. Support was provided according to Brazilian Tobacco Control Program and consisted of cognitive behavioral therapy in addition to nicotine replacement therapy. Logistic regression and the Cox proportional hazard models were used in the analysis. Results There was an increase of 34%, 48% and 97% in the chances of patients stop smoking for at least six months, 12 months and 24 months, respectively, for each new session that the patient participated. Patients that attended three or more meetings had a 79% lower risk of returning to smoking than those who went to less than three meetings. Conclusions Although not all patients who were enrolled in the program could be contacted for the study, our results indicate that about 40% of patients are able to stay smoke-free for at least three months due to the smoking cessation program, but less than 20% are able to remain smoke-free for two years. Initiatives to improve adherence to cognitive behavioral therapy meetings according to the specificity of the population may increase the effectiveness of the program.

  15. Parents' experiences and the effect on the family two years after their child was admitted to a PICU-An interview study.

    Science.gov (United States)

    Terp, Karina; Sjöström-Strand, Annica

    2017-12-01

    For parents, having a child admitted to a paediatric intensive care unit (PICU) is a very stressful experience filled with anxiety. Parents are often scared and traumatised. This stress can lead to PTSD. The aim was to describe parents' experiences and the effect on the family two years after their child was admitted to a paediatric intensive care unit. Ten parents were interviewed according to a semi-structured interview guide. An inductive approach was applied for the study and qualitative content analysis was used to analyse the data. The parents carried vivid memories and they were still strongly affected by the experience of having their child admitted to a paediatric intensive care unit. They could clearly recall the environment, feelings that affected them and how they felt powerless. The relationship between the parents had been strengthened. Parents, siblings and the ill child could all show symptoms of anxiety, stress and sleeping disorders. The parents valued life differently. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Leech Therapy For The Treatment Of Venous Congestion In Flaps, Digital Re-Plants And Revascularizations - A Two-Year Review From A Regional Centre.

    Science.gov (United States)

    Butt, Ahsan Masood; Ismail, Amir; Lawson-Smith, Matthew; Shahid, Muhammad; Webb, Jill; Chester, Darren L

    2016-01-01

    Leeches are a well-recognized treatment for congested tissue. This study reviewed the efficacy of leech therapy for salvage of venous congested flaps and congested replanted or revascularized hand digits over a 2-year period. All patients treated with leeches between 1 Oct 2010 and 30 Sep 2012 (two years) at Queen Elizabeth Hospital, Birmingham, UK were included in the study. Details regarding mode of injury requiring reconstruction, surgical procedure, leech therapy duration, subsequent surgery requirement and tissue salvage rates were recorded. Twenty tissues in 18 patients required leeches for tissue congestion over 2 years: 13 men and 5 women. The mean patient age was 41 years (range 17-79). The defect requiring reconstruction was trauma in 16 cases, following tumour resection in two, and two miscellaneous causes. Thirteen cases had flap reconstruction and seven digits in six patients had hand digit replantations or revascularisation. Thirteen of 20 cases (65%) had successful tissue salvage following leech therapy for congestion (77% in 10 out of 13 flaps, and 43% in 3 of 7 digits). The rate of tissue salvage in pedicled flaps was good 6/6 (100%) and so was in digital revascularizations 2/3 (67%), but poor in digital re-plants 1/4 (25%) and free flaps 0/2 (0%). Leeches are a helpful tool for congested tissue salvage and in this study, showed a greater survival benefit for pedicled flaps than for free flaps or digital replantations.

  17. Physiologic and skeletal response to exogenous equine somatotropin (eST) in two-year-old quarter horses in race training

    International Nuclear Information System (INIS)

    Day, T.R.J; Potter, G.D.; Morris, E.L.; Greene, L.W.; Simmons, J.B.

    1998-01-01

    This study was conducted to determine the physiologic and skeletal response to exogenous equine somatotropin (eST) in two-year-old horses in race training. Sixteen Quarter Horse geldings were paired by age (ave. age=26 months), and one horse from each pair was assigned at random to either the eST treatment group or the control. The experiment was conducted over 112 days during which the horses were broke to ride and trained on a dirt track in a regimen typical for racehorses in training. Radiographs were taken of the left third metacarpal on day 0,28, 42, 56, 70, 84 and 112. Jugular blood samples were collected every 14 days and analyzed for calcium (Ca), phosphorous (P), osteocalcin, 25-dihydroxyvitamin D (Vit D), parathyroid hormone (PTH), insulin-like growth factor-I (IGF-I) and growth hormone (GH). Daily injections of eST were well tolerated and resulted in no observed side effects. There was a trend (P= .14) for increased plasma GH concentrations in the treated horses as the trial progressed. Plasma IGF-I concentrations were increased (P .05). In this study, administration of eST was effective in elevating plasma IGF-I, which is stimulatory to osteoblasts, and serum osteocalcin, which is a product of osteoblastic activity

  18. The Result of The Treatment of Infantile Spasm After Two Year Follow-Up Review Of 45 Cases in Ten Past Years

    Directory of Open Access Journals (Sweden)

    A Nasirian

    2001-06-01

    Full Text Available In the past ten years, 45 cases of infantile spasm treated in our center. From these patients, 15 cases received only steroid, other 15 cases only clonazepam, and the rest, a combination of clonazepam and steroid. All patients were observed for two years. This is a retrospective study, the data being extracted from patients record. A number of patients were treated in ambulatory and the others were patients of the hospital. The result of comparison of optimal control of seizures are as follow: 1 In only steroid group 27 percent of the patients were free of seizure, 2 In only clonazepam group 28 percent showed no seizure, 3 in combined clonazepam and steroid group 39% were seizure-free. Based on this trial we believe that treatment of infantile spasm with combined steroid and clonazepam is better than any of them alone. Considering these results, we believe that the treatment of infantile spasm with a combination of steroid and clonazepam is preferable to these drugs.

  19. Open versus arthroscopic approach in the treatment of femoroacetabular impingement: a case–control study with two-years follow up

    Directory of Open Access Journals (Sweden)

    Bruno Dutra Roos

    Full Text Available Abstract Objective To compare clinical and imaging results and complications between patients treated for femoroacetabular impingement (FAI who underwent either anterior open surgery or an arthroscopic approach, with a minimum follow-up of two years. Methods This retrospective case–control study included patients submitted to FAI surgical treatment between November 2007 and March 2012. Patients treated with open surgery were compared with those treated with arthroscopy. Patients were clinically assessed by the modified Harris Hip Score, Non-Arthritic Hip Score, and internal hip rotation. Patients were radiographically assessed by the center-edge angle, joint space width, alpha angle, neck-head index, degree of arthrosis, and presence of heterotopic ossification of the hip. Results In the study period, 56 patients (58 hips with FAI were included; 16 underwent open surgery and 40 underwent arthroscopy. The 40 patients treated by the arthroscopic route had a mean follow-up of 29.1 months, and 75.6% presented good or excellent clinical results. The radiographic evaluation parameters progressed to normal levels. The 16 patients who underwent open surgery had a mean follow-up of 52 months, and 70.58% presented good or excellent clinical results. The radiographic evaluation parameters progressed to normal levels. Postoperative clinical and radiographic results were considered similar in both groups. Conclusions Arthroscopy and open surgery treatments for FAI provided comparable clinical and radiographic results. However, a higher rate of complications was observed in the open surgery group.

  20. Ovine Enzootic Abortion (OEA: a comparison of antibody responses in vaccinated and naturally-infected swiss sheep over a two year period

    Directory of Open Access Journals (Sweden)

    Zimmermann Dieter R

    2007-09-01

    Full Text Available Abstract Background Prevention and control of ovine enzootic abortion (OEA can be achieved by application of a live vaccine. In this study, five sheep flocks with different vaccination and infection status were serologically tested using a competitive enzyme-linked immunosorbent assay (cELISA specific for Chlamydophila (Cp. abortus over a two-year time period. Results Sheep in Flock A with recent OEA history had high antibody values after vaccination similar to Flock C with natural Cp. abortus infections. In contrast, OEA serology negative sheep (Flock E showed individual animal-specific immunoreactions after vaccination. Antibody levels of vaccinated ewes in Flock B ranged from negative to positive two and three years after vaccination, respectively. Positive antibody values in the negative control Flock D (without OEA or vaccination are probably due to asymptomatic intestinal infections with Cp. abortus. Excretion of the attenuated strain of Cp. abortus used in the live vaccine through the eye was not observed in vaccinated animals of Flock E. Conclusion The findings of our study indicate that, using serology, no distinction can be made between vaccinated and naturally infected sheep. As a result, confirmation of a negative OEA status in vaccinated animals by serology cannot be determined.

  1. The Heliopause Electrostatic Rapid Transit System (HERTS) - Design, Trades, and Analyses Performed in a Two Year NASA Investigation of Electric Sail Propulsion Systems

    Science.gov (United States)

    Wiegmann, Bruce M.; Scheider, Todd; Heaton, Andrew; Vaughn, Jason; Stone, Nobie; Wright, Ken

    2017-01-01

    Personnel from NASA's MSFC have been investigating the feasibility of an advanced propulsion system known as the Electric Sail (E-Sail) for future scientific exploration missions. This team initially won a NASA Space Technology Mission Directorate (STMD) Phase I NASA Innovative Advanced Concept (NIAC) award and then a two-year follow-on Phase II NIAC award in October 2015. This paper documents the findings from this three-year investigation. An Electric sail, a propellant-less propulsion system, uses solar wind ions to rapidly travel either to deep space or the inner solar system. Scientific spacecraft could reach Pluto in 5 years, or the boundary of the solar system in ten to twelve years compared to the thirty-five plus years the Voyager spacecraft took. The team's recent focuses have been: 1) Developing a Particle in Cell (PIC) numeric engineering model from MSFC's experimental data on the interaction between simulated solar wind and a charged bare wire that can be applied to a variety of missions, 2) Determining what missions could benefit from this revolutionary propulsion system, 3) Conceptualizing spacecraft designs for various tasks: to reach the solar system's edge, to orbit the sun as Heliophysics sentinels, or to examine a multitude of asteroids.

  2. Sublingual immunotherapy in patients with house dust mite allergic rhinitis: prospective study of clinical outcomes over a two-year period.

    Science.gov (United States)

    Soh, J Y; Thalayasingam, M; Ong, S; Loo, E X L; Shek, L P; Chao, S S

    2016-03-01

    Sublingual immunotherapy in patients with allergic rhinitis sensitised to house dust mites is safe, but its efficacy is controversial and sublingual immunotherapy with Blomia tropicalis has not yet been studied. This study sought to evaluate the efficacy of sublingual immunotherapy with house dust mite extract in children and adults with house dust mite allergic rhinitis over a period of two years. A prospective observational study was conducted of children and adults diagnosed with house dust mite allergic rhinitis who were treated with sublingual immunotherapy from 2008 to 2012. Total Nasal Symptom Scores, Mini Rhinoconjunctivitis Quality of Life scores and medication usage scores were assessed prospectively. Thirty-nine patients, comprising 24 children and 15 adults, were studied. Total Nasal Symptom Scores and Mini Rhinoconjunctivitis Quality of Life scores dropped significantly at three months into therapy, and continued to improve. Medication usage scores improved at one year into immunotherapy. Sublingual immunotherapy with house dust mite extracts, including B tropicalis, is efficacious as a treatment for patients with house dust mite allergic rhinitis.

  3. The persistent prevalence and evolution of cross-family recombinant coronavirus GCCDC1 among a bat population: a two-year follow-up.

    Science.gov (United States)

    Obameso, Joseph O; Li, Hong; Jia, Hao; Han, Min; Zhu, Shiyan; Huang, Canping; Zhao, Yuhui; Zhao, Min; Bai, Yu; Yuan, Fei; Zhao, Honglan; Peng, Xia; Xu, Wen; Tan, Wenjie; Zhao, Yingze; Yuen, Kwok-Yung; Liu, William J; Lu, Lin; Gao, George F

    2017-12-01

    Bats are connected with the increasing numbers of emerging and re-emerging viruses that may break the species barrier and spread into the human population. Coronaviruses are one of the most common viruses discovered in bats, which were considered as the natural source of recent human-susceptible coronaviruses, i.e. SARS-COV and MERS-CoV. Our previous study reported the discovery of a bat-derived putative cross-family recombinant coronavirus with a reovirus gene p10, named as Ro-BatCoV GCCDC1. In this report, through a two-year follow-up of a special bat population in one specific cave of south China, we illustrate that Ro-BatCoV GCCDC1 persistently circulates among bats. Notably, through the longitudinal observation, we identified the dynamic evolution of Ro-BatCoV GCCDC1 in bats represented by continuously recombination events. Our study provides the first glimpse of the virus evolution in one longitudinally observed bat population cohort and underlines the surveillance and pre-warning of potential interspecies transmittable viruses in bats.

  4. WAVE~Ripples for Change Obesity Two-Year Intervention in High School Soccer Players: Process Evaluation, Best Practices, and Youth Engagement

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    Yu Meng

    2018-06-01

    Full Text Available This paper reports the process data on program fidelity, best practices for intervention implementation, youth and coach engagement, and youth application of knowledge and skills for the two-year WAVE~Ripples for Change (WAVE obesity prevention intervention program focused on healthy eating, physical activity, and life skills with high school (HS soccer players aged 14–19 years. Internal (staff: n = 7; volunteers: n = 27 and external (youth: n = 100; coaches: n = 9 stakeholders were interviewed/ surveyed. Staff rated program fidelity as high (94%, as did volunteers (85%. Best practices included coach encouragement for athlete participation, use of on-line consent for enrollment, building relationships with HS staff to complete assessments, sending text reminders, and providing incentives. Study results showed an enrollment rate of 72%, completion of baseline assessments of 89–98%, attendance of sports nutrition lessons in Year 1 and Year 2 of 90% and 39%, respectively, and team-building workshop (TBW attendance of 25–31%. Activities exceeding youth expectations (>90% included, (1 activities with their soccer team; (2 the TBW-cooking; and (3 sports nutrition lessons. The obesity prevention skills most applied by youth were obtained from the TBW-gardening and harvesting (49%, the TBW-cooking (43%, and sports nutrition lessons (44%. Coaches also rated the sports nutrition lessons highly and reported increased awareness for hydration/fueling during sport by the athletes. Using sport teams/clubs to engage youth in obesity prevention is a feasible model for future study.

  5. Monitoring safety and use of old and new treatment options for type 2 diabetic patients: a two-year (2013-2016) analysis.

    Science.gov (United States)

    Leporini, Christian; Piro, Rosanna; Ursini, Francesco; Maida, Francesca; Palleria, Caterina; Arturi, Franco; Pavia, Maria; De Sarro, Giovambattista; Russo, Emilio

    2016-12-01

    To compare patients' and physicians' perceptions regarding effectiveness and tolerability of non-insulin hypoglycemic drugs in a cohort of type 2 diabetic patients; to verify whether a possible tridimensional link between effectiveness, tolerability, and adherence affects long-term therapeutic outcomes. A two-year observational study was performed in 1389 Type 2 diabetic patients by involving general practitioner clinics and Diabetes Centers. A decimal scale and the Morisky questionnaire were used, respectively, to assess effectiveness and tolerability perceptions, and medication adherence. Physicians perceived therapy as more efficacious compared to their patients: perceived effectiveness was steady for physicians during the study whereas patients' perception not significantly decreased (mean score from >8 to 7.84 ± 1.69). Physicians assigned higher tolerability scores compared to patients but only at the beginning of the study; interestingly, physicians' tolerability perception was poorer than patients' perception at last follow-up (mean score = 7.57 ± 1.40 vs. 7.88 ± 1.84). Favorable (score >7) patients' perceptions about treatment effectiveness and tolerability were associated with higher adherence. Patients showed medium adherence across the study. A mutual relationship between clinical effectiveness, adverse drug reactions, and adherence has been established, significantly impacting the clinical management of diabetic patients. A careful monitoring of this link by clinicians appears therefore necessary.

  6. Schistosoma mansoni control in Cul de Sac Valley, Saint Lucia. I. A two-year focal surveillance-mollusciciding programme for the control of Biomphalaria glabrata.

    Science.gov (United States)

    Barnish, G; Christie, J D; Prentice, M A

    1980-01-01

    An area-wide mollusciciding campaign in Cul de Sac valley, St. Lucia reduced incidence of Schistosoma mansoni from 22% to 4.3% between 1970 and 1975. Following this, a two-year focal surveillance-mollusciciding programme was introduced. Sites of potential transmission of S. mansoni were identified and routinely searched for Biomphalaria glabrata. If found, the site was treated with clonitralide 25% emulsifiable concentrate. Two chemotherapy campaigns supplemented the snail control programme. As a result of the combined measures, incidence of the infection dropped from 4.3% to 1.0% and from 2.2% to 0.6% in areas originally of high and low transmission respectively. The cost of protecting the 7,000 population was US $20,362: of these costs, labour absorbed 68%, transport 24%, equipment 4% and molluscicide 4%. The cost per person per year protected was US $1.45 which compares favourably with the $3.24 of the previous scheme. Although effective and relatively cheap, this programme was still dependent on a high standard of supervision for maximum benefit.

  7. Plutonium inventories for stabilization and stabilized materials

    Energy Technology Data Exchange (ETDEWEB)

    Williams, A.K.

    1996-05-01

    The objective of the breakout session was to identify characteristics of materials containing plutonium, the need to stabilize these materials for storage, and plans to accomplish the stabilization activities. All current stabilization activities are driven by the Defense Nuclear Facilities Safety Board Recommendation 94-1 (May 26, 1994) and by the recently completed Plutonium ES&H Vulnerability Assessment (DOE-EH-0415). The Implementation Plan for accomplishing stabilization of plutonium-bearing residues in response to the Recommendation and the Assessment was published by DOE on February 28, 1995. This Implementation Plan (IP) commits to stabilizing problem materials within 3 years, and stabilizing all other materials within 8 years. The IP identifies approximately 20 metric tons of plutonium requiring stabilization and/or repackaging. A further breakdown shows this material to consist of 8.5 metric tons of plutonium metal and alloys, 5.5 metric tons of plutonium as oxide, and 6 metric tons of plutonium as residues. Stabilization of the metal and oxide categories containing greater than 50 weight percent plutonium is covered by DOE Standard {open_quotes}Criteria for Safe Storage of Plutonium Metals and Oxides{close_quotes} December, 1994 (DOE-STD-3013-94). This standard establishes criteria for safe storage of stabilized plutonium metals and oxides for up to 50 years. Each of the DOE sites and contractors with large plutonium inventories has either started or is preparing to start stabilization activities to meet these criteria.

  8. Trapped particle stability for the kinetic stabilizer

    Science.gov (United States)

    Berk, H. L.; Pratt, J.

    2011-08-01

    A kinetically stabilized axially symmetric tandem mirror (KSTM) uses the momentum flux of low-energy, unconfined particles that sample only the outer end-regions of the mirror plugs, where large favourable field-line curvature exists. The window of operation is determined for achieving magnetohydrodynamic (MHD) stability with tolerable energy drain from the kinetic stabilizer. Then MHD stable systems are analysed for stability of the trapped particle mode. This mode is characterized by the detachment of the central-cell plasma from the kinetic-stabilizer region without inducing field-line bending. Stability of the trapped particle mode is sensitive to the electron connection between the stabilizer and the end plug. It is found that the stability condition for the trapped particle mode is more constraining than the stability condition for the MHD mode, and it is challenging to satisfy the required power constraint. Furthermore, a severe power drain may arise from the necessary connection of low-energy electrons in the kinetic stabilizer to the central region.

  9. Releasing the digital elevation model for the whole Italian territory: a case study reporting two years of core-data dissemination for Earth Sciences communities and other stakeholders

    Science.gov (United States)

    Tarquini, Simone; Nannipieri, Luca

    2014-05-01

    EPOS (European Plate Observing System) is the European initiative for the implementation and integration of European Research Infrastructures in the field of Solid Earth Sciences. In particular, EPOS is aimed at creating a common environment for data exchange for both the scientific community and relevant stakeholders interested in Earth Sciences. In such a context, a service providing access to the complete topography of one of the countries participating in EPOS represents a step forward towards the realization of the EPOS mission. Here we report about two years of activity of a data dissemination service which released (for free) a digital elevation model (DEM) of the whole Italian territory at 10 m-resolution named TINTALY/01. The new TINITALY/01 DEM for the whole Italian territory was completed and presented by INGV in 2007. This DEM was the final result of a project funded by the Italian Ministry of the Environment. TINITALY/01 was completed in two phases: in a first phase, independent elevation models for single regions were derived, and in a second phase, all the regional models were merged into a single, seamless model covering the whole territory of Italy. In early 2012, a web portal was published (http://tinitaly.pi.ingv.it/) through which the above DEM is open for a full web-GIS navigation (3-D navigation in anaglyph mode or standard 2-D hillshade), and where internet navigators can ask for the download of the DEM dataset (in grid format, 10 m-resolution) through the compilation of an online form (http://tinitaly.pi.ingv.it/account_request_form.html). Submission of the form implies stating the destination of use for the data, and acceptance of the policy of use (i.e. no-profit use). After nearly two years from the opening of the portal, the DEM is still browsed by up to 10-20 users per day (about 3000 visits throughout 2013). As of 31 December 2013, about 220 users affiliated to nearly 150 different institutions or associations (i.e. universities

  10. IMMUNOGENICITY AND SAFETY OF 23-VALENT POLYSACCHARIDE PNEUMOCOCCAL VACCINE IN PATIENTS WITH RHEUMATOID ARTHRITIS: RESULTS OF A TWO-YEAR FOLLOW-UP STUDY

    Directory of Open Access Journals (Sweden)

    M. S. Naumtseva

    2016-01-01

    Full Text Available Objective: to investigate the immunogenicity, safety, and clinical efficacy of 23-valent polysaccharide pneumococcal vaccine in patients with rheumatoid arthritis (RA during a two-year follow-up study.Subjects and methods. The prospective open-label comparative study enrolled 110 people, of them there were 81 (73.6% women and 29 (26.4% men at the age of 23 to 76 years, including 79 patients with RA, as well as 31 subjects without systemic inflammatory rheumatic diseases (RD (a control group. The group of RA patients exhibited a predominance of middle-aged women who had > 3 years’ disease duration and a moderate inflammatory activity (the mean value of DAS28, 4.32. 52 patients received methotrexate (MTX, 14 had Leflunomide (LEF, and 13 were treated with tumor necrosis factor-α (TNF-α inhibitors + MTX.The 23-valent polysaccharide pneumococcal vaccine Pneumo-23 (Sanofi Pasteur, France was administered in a single dose of 0.5 ml subcutaneously during continuous MTX or LEF therapy for the underlying disease or 3–4 weeks before the use of TNF-α inhibitors. Clinical examinations of the patient and conventional clinical and laboratory studies were performed during control visits (1, 3, 12, and 24 months after vaccination. Clinical effectiveness and safety were evaluated in all the patients included in the study. The serum levels of anti-pneumococcal capsular polysaccharide antibodies (Ab were measured in 72 patients with RA and in 30 individuals in the control group during a 12-month follow-up study, including in 25 patients with RA for a 24-month follow-up study by enzyme immunoassay using commercial VaccZymeTM Anti-PCP IgG Enzyme Immunoassay kits (The Binding Site Group Ltd, Birmingham, United Kingdom. Along with this, the post-immunization response coefficient was calculated for each patient as the ratio of postvaccination Ab levels during Visits 2, 3, 4, and 5 to the baseline Ab level. Results and discussion. No clinical and

  11. Efficacy of sulfadoxine-pyrimethamine in Tanzania after two years as first-line drug for uncomplicated malaria: assessment protocol and implication for treatment policy strategies

    Directory of Open Access Journals (Sweden)

    Felger Ingrid

    2005-11-01

    Full Text Available Abstract Background Systematic surveillance for resistant malaria shows high level of resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine (SP across eastern and southern parts of Africa. This study assessed in vivo SP efficacy after two years of use as an interim first-line drug in Tanzania, and determined the rates of treatment failures obtained after 14 and 28 days of follow-up. Methods The study was conducted in the Ipinda, Mlimba and Mkuranga health facilities in Tanzania. Children aged 6–59 months presenting with raised temperature associated exclusively with P. falciparum (1,000–100,000 parasites per μl were treated with standard dose of SP. Treatment responses were classified according to the World Health Organization (WHO definition as Adequate Clinical and Parasitological Response (ACPR, Early Treatment Failure (ETF, Late Clinical Failure (LCF and Late Parasitological Failure (LPF on day 14 and day 28. Results Overall 196 (85.2% of 230 patients had ACPR on day 14 but only 116 (50.9% on day 28 (57.7% after excluding new infections by parasite genotyping. Altogether 21 (9.1% and 13 (5.7% of the 230 patients assessed up to day 14 and 39 (17.1% and 55 (24.1% of the 228 followed up to day 28 had clinical and parasitological failure, respectively. Conclusion These findings indicate that SP has low therapeutic value in Tanzania. The recommendation of changing first line treatment to artemether + lumefantrine combination therapy from early next year is, therefore, highly justified. These findings further stress that, for long half-life drugs such as SP, establishment of cut-off points for policy change in high transmission areas should consider both clinical and parasitological responses beyond day 14.

  12. Epidemiology of Acute Gastroenteritis Outbreaks Caused by Human Calicivirus (Norovirus and Sapovirus in Catalonia: A Two Year Prospective Study, 2010-2011.

    Directory of Open Access Journals (Sweden)

    Nuria Torner

    Full Text Available The epidemiology of cases of acute gastroenteritis (AGE of viral etiology is a relevant public health issue. Due to underreporting, the study of outbreaks is an accepted approach to investigate their epidemiology. The objective of this study was to investigate the epidemiological characteristics of AGE outbreaks due to norovirus (NoV and sapovirus (SV in Catalonia.Prospective study of AGE outbreaks of possible viral etiology notified during two years in Catalonia. NoV and SV were detected by real time reverse transcription polymerase (RT-PCR.A total of 101 outbreaks were registered affecting a total of 2756 persons and 12 hospitalizations (hospitalization rate: 0.8x1,000,000 persons-year; 49.5% of outbreaks were foodborne, 45.5% person to person and 5% waterborne. The distribution of outbreaks according to the setting showed a predominance of catering services (39.6%, nursing homes and long term care facilities (26.8% and schools (11.9%. The median number of cases per outbreak was 17 (range 2-191. The total Incidence rate (IR was 18.3 per 100,000 persons-years (95%CI: 17.6-19.0. The highest IR was in persons aged ≥65 years (43.6x100,000 (95% CI: 41.0-46.2 (p<0.001. A total of 1065 samples were analyzed with a positivity rate of 60.8%. 98% of positive samples were NoV (GII 56.3%; GI 4.2%; GII+GI 4.2%; non- typable 33.0%. SV was identified in two person-to-person transmission outbreaks in children.These results confirm the relevance of viral AGE outbreaks, both foodborne and person-to-person, especially in institutionalized persons. SV should be taken into account when investigating viral AGE outbreaks.

  13. Searches for new Milky Way satellites from the first two years of data of the Subaru/Hyper Suprime-Cam survey: Discovery of Cetus III

    Science.gov (United States)

    Homma, Daisuke; Chiba, Masashi; Okamoto, Sakurako; Komiyama, Yutaka; Tanaka, Masayuki; Tanaka, Mikito; Ishigaki, Miho N.; Hayashi, Kohei; Arimoto, Nobuo; Garmilla, José A.; Lupton, Robert H.; Strauss, Michael A.; Miyazaki, Satoshi; Wang, Shiang-Yu; Murayama, Hitoshi

    2018-01-01

    We present the results from a search for new Milky Way (MW) satellites from the first two years of data from the Hyper Suprime-Cam (HSC) Subaru Strategic Program (SSP) ˜300 deg2 and report the discovery of a highly compelling ultra-faint dwarf galaxy candidate in Cetus. This is the second ultra-faint dwarf we have discovered after Virgo I reported in our previous paper. This satellite, Cetus III, has been identified as a statistically significant (10.7 σ) spatial overdensity of star-like objects, which are selected from a relevant isochrone filter designed for a metal-poor and old stellar population. This stellar system is located at a heliocentric distance of 251^{+24}_{-11}kpc with a most likely absolute magnitude of MV = -2.4 ± 0.6 mag estimated from a Monte Carlo analysis. Cetus III is extended with a half-light radius of r_h = 90^{+42}_{-17}pc, suggesting that this is a faint dwarf satellite in the MW located beyond the detection limit of the Sloan Digital Sky Survey. Further spectroscopic studies are needed to assess the nature of this stellar system. We also revisit and update the parameters for Virgo I, finding M_V = -0.33^{+0.75}_{-0.87}mag and r_h = 47^{+19}_{-13}pc. Using simulations of Λ-dominated cold dark matter models, we predict that we should find one or two new MW satellites from ˜300 deg2 HSC-SSP data, in rough agreement with the discovery rate so far. The further survey and completion of HSC-SSP over ˜1400 deg2 will provide robust insights into the missing satellites problem.

  14. Phenotypes of sleep-disordered breathing symptoms to two years of age based on age of onset and duration of symptoms.

    Science.gov (United States)

    Kamal, Muna; Tamana, Sukhpreet K; Smithson, Lisa; Ding, Linda; Lau, Amanda; Chikuma, Joyce; Mariasine, Jennifer; Lefebvre, Diana L; Subbarao, Padmaja; Becker, Allan B; Turvey, Stuart E; Sears, Malcolm R; Pei, Jacqueline; Mandhane, Piush J

    2018-05-03

    Childhood sleep-disordered breathing (SDB) symptoms may comprise multiple phenotypes depending on craniofacial anatomy, tonsil and adenoid growth, body habitus, and rhinitis symptoms. The primary objective of this study is to identify and characterize the different SDB phenotypes to two years of age. Data from 770 infants in the Edmonton sub-cohort of the Canadian Healthy Infant Longitudinal Study (CHILD) were analyzed to identify SDB phenotypes based on age of onset and duration of symptoms. Parents completed the 22-item sleep-related breathing disorder (SRBD) scale. Children with a SRBD ratio greater than 0.33 were considered positive for SDB at each quarterly assessment between three months and two years. The STATA Proc trajectory extension identified SDB phenotypes based on their age of onset and duration of symptoms and attributed the percentage chance of a participant being assigned to each phenotype. Multivariate linear regression identified factors associated with increased risk of being assigned to each SDB phenotype. Trajectory analysis identified four phenotypes: no SDB (65.7%), early-onset SDB (15.7%) with peak symptoms at nine months, late-onset SDB (14.2%) with peak symptoms at 18 months, and persistent SDB (5.3%) with symptoms from 3 to 24 months. Rhinitis was associated with all three SDB symptom trajectories (p sleep apnea syndrome (OSAS) was associated with persistent (p = 0.01) and late SDB (p < 0.001). Atopy (positive skin prick test at one year) was associated with persistent SDB (p = 0.04). Infants born prior to 36.5 weeks gestational age were more likely to present with late SDB (p = 0.03). Childhood SDB symptoms, rather than being a homogenous disorder, may comprise multiple overlapping phenotypes each with unique risk factors. Copyright © 2018 Elsevier B.V. All rights reserved.

  15. Factors Associated with Relapse among Heroin Addicts: Evidence from a Two-Year Community-Based Follow-Up Study in China

    Directory of Open Access Journals (Sweden)

    Chao Rong

    2016-01-01

    Full Text Available Background: Many countries including China are facing a serious opiate dependence problem. Anti-drug work effectiveness was affected by the high relapse rate all over the world. This study aims to analyze the factors influencing heroin addict relapse, and to provide evidence for generating relapse prevention strategies. Methods: A community-based follow-up study was conducted in China between October 2010 and September 2012. A total of 554 heroin addicts in accordance with the inclusion criteria from 81 streets in 12 districts of Shanghai, China were divided into 4 groups: group 1—daily dosage taken orally of 60 mL of methadone or under combined with psychological counseling and social supports (n = 130; group 2—daily dosage taken orally of over 60 mL of methadone combined with psychological counseling and social supports (n = 50; group 3—JTT (Jitai tablets combined with psychological counseling and social supports (n = 206; group 4—JTT combined with social supports (n = 168. Results: Log-rank test results showed that the cumulative relapse rate differences among four groups during the two-year follow-up period were not statistically significant (χ2 = 5.889, p = 0.117. Multivariate Cox regression analysis results showed that only three independent variables were still statistically significant, including compliance with participation in psychological counseling (OR = 3.563, p = 0.000, the years of drug use (OR = 1.078, p = 0.001and intervention model. Conclusions: Using the detoxification medications combined with appropriate psychological counseling and social support measures will help improve the effectiveness of relapse prevention, which is a kind of alternative community detoxification pattern. Appropriate and standard psychological counseling is very important for anti-drug treatment. The longer the drug addiction lasts, the longer the anti-drug treatment takes.

  16. A Two-Year Study on Mercury Fluxes from the Soil under Different Vegetation Cover in a Subtropical Region, South China

    Directory of Open Access Journals (Sweden)

    Ming Ma

    2018-01-01

    Full Text Available In order to reveal the mercury (Hg emission and exchange characteristics at the soil–air interface under different vegetation cover types, the evergreen broad-leaf forest, shrub forest, grass, and bare lands of Simian Mountain National Nature Reserve were selected as the sampling sites. The gaseous elementary mercury (GEM fluxes at the soil–air interface under the four vegetation covers were continuously monitored for two years, and the effect of temperature and solar radiation on GEM fluxes were also investigated. Results showed that the GEM fluxes at the soil–air interface under different vegetation cover types had significant difference (p < 0.05. The bare land had the maximum GEM flux (15.32 ± 10.44 ng·m−2·h−1, followed by grass land (14.73 ± 18.84 ng·m−2·h−1, and shrub forest (12.83 ± 10.22 ng·m−2·h−1, and the evergreen broad-leaf forest had the lowest value (11.23 ± 11.13 ng·m−2·h−1. The GEM fluxes at the soil–air interface under different vegetation cover types showed similar regularity in seasonal variation, which mean that the GEM fluxes in summer were higher than that in winter. In addition, the GEM fluxes at the soil–air interface under the four vegetation covers in Mt. Simian had obvious diurnal variations.

  17. Translocation and bonding of calcium (45Ca) in two-year-old seedlings of spruce (Picea abies[L.] Karst.) and pine (Pinus sylvestris L.)

    International Nuclear Information System (INIS)

    Tuerk, S.H.

    1995-12-01

    Within the framework of the project ''Effect of liming and magnesium fertilization on the uptake, transport, and chemical bonding form of calcium and magnesium in conifers'', experiments regarding the calcium budget of two-year-old spruce and pine seedlings under conditions of controlled nutrition in a gravel culture were carried out. Two variants of calcium nutrition demonstrated which of the mechanisms in the calcium metabolism of trees are dependent on changes in element availability. Root labelling using the radioactive tracer 45 Ca permitted aimed investigation of the uptake and translocation of calcium during shoot formation in May. The functional importance of the investigated nutritive element was characterized by breaking up the total calcium contents ( 45 Ca) into the three essential chemical bonding forms (water-soluble Ca, Ca-pectate, Ca-oxalate) for the different tree fractions.- The culture experiments led to the conclusion that the root tips are most important as sites of calcium uptake. Translocation within the roots to the shoot took place via diffusion and exchange displacement as a function of calcium supply in the nutritive solution. There is no clue to support the assumption of a regulation of calcium uptake in spruces; in pines, by contrast, it cannot be excluded.- From a nutrition-physiological viewpoint, a total calcium content of 2 mg per gramme of dry mass is to be considered as sufficient. As this target is always attained, even where calcium supply is scarce, it is not appropriate to equate increased calcium availability with enhanced nutrient supply. Rather, the results discussed seem to support the theory that the trees now need to detoxicate excessively high calcium concentrations, which are liable to endanger the physiological cell metabolism, by a reaction with oxalic acid resulting in the formation of calcium oxalate. (orig.) [de

  18. Changes in higher order aberrations after wavefront-guided PRK for correction of low to moderate myopia and myopic astigmatism: two-year follow-up.

    Science.gov (United States)

    Wigledowska-Promienska, D; Zawojska, I

    2007-01-01

    To assess efficacy, safety, and changes in higher order aberrations after wavefront-guided photorefractive keratectomy (PRK) in comparison with conventional PRK for low to moderate myopia with myopic astigmatism using a WASCA Workstation with the MEL 70 G-Scan excimer laser. A total of 126 myopic or myopic-astigmatic eyes of 112 patients were included in this retrospective study. Patients were divided into two groups: Group 1, the study group; and Group 2, the control group. Group 1 consisted of 78 eyes treated with wavefront-guided PRK. Group 2 consisted of 48 eyes treated with spherocylindrical conventional PRK. Two years postoperatively, in Group 1, 5% of eyes achieved an uncorrected visual acuity (UCVA) of 0.05; 69% achieved a UCVA of 0.00; 18% of eyes experienced enhanced visual acuity of -0.18 and 8% of -0.30. In Group 2, 8% of eyes achieved a UCVA of 0.1; 25% achieved a UCVA of 0.05; and 67% achieved a UCVA of 0.00 according to logMAR calculation method. Total higher-order root-mean square increased by a factor 1.18 for Group 1 and 1.6 for Group 2. There was a significant increase of coma by a factor 1.74 in Group 2 and spherical aberration by a factor 2.09 in Group 1 and 3.56 in Group 2. The data support the safety and effectiveness of the wavefront-guided PRK using a WASCA Workstation for correction of low to moderate refractive errors. This method reduced the number of higher order aberrations induced by excimer laser surgery and improved uncorrected and spectacle-corrected visual acuity when compared to conventional PRK.

  19. Evaluation of changes in equine care and limb-related abnormalities in working horses in Jaipur, India, as part of a two year participatory intervention study.

    Science.gov (United States)

    Whay, Helen R; Dikshit, Amit K; Hockenhull, Jo; Parker, Richard M A; Banerjee, Anindo; Hughes, Sue I; Pritchard, Joy C; Reix, Christine E

    2015-01-01

    Previous studies have found the prevalence of lameness in working horses to be 90-100%. Risk factors for lameness in this important equine population, together with risk-reduction strategies adopted by their owners, are poorly understood. The objective was to uncover risk factors for lameness and limb abnormalities in working horses, by associating clinical lameness examination findings on three occasions over two years with owner reported changes in equine management and work practices over this period. Twenty-one communities of horse owners in Jaipur, India, took part in a participatory intervention (PI) project aiming to reduce risk factors for poor welfare, particularly lameness and limb problems. Associations between quantitative measures of equine lameness/limb abnormalities and reported changes in management and work practices were compared with 21 control (C) communities of owners where no intervention had taken place. Key findings from 'complete cases', where the same horse stayed with the same owner for the whole study period (PI group = 73 owners of 83 horses, C group = 58 owners of 66 horses), were that more positive statements of change in equine management and work practices were made by PI group owners than C group owners. A mixed picture of potential risk factors emerged: some reported management improvements, for example reducing the weight of the load for cart animals, were associated with improved limbs and lameness, and others, such as making improvements in shoeing and increasing the age at which their animals started work, with negative outcomes. This study illustrates the complexity and interacting nature of risk factors for lameness in working horses, and highlights the importance of longitudinal investigations that recognise and address this. PI group owners found the project useful and requested similar inputs in future. Our findings demonstrate the value of exploratory and participatory research methodology in the field of working horse

  20. SU-C-9A-02: Structured Noise Index as An Automated Quality Control for Nuclear Medicine: A Two Year Experience

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, J; Christianson, O; Samei, E [Duke University Medical Center, Durham, NC (United States)

    2014-06-01

    Purpose: Flood-field uniformity evaluation is an essential element in the assessment of nuclear medicine (NM) gamma cameras. It serves as the central element of the quality control (QC) program, acquired and analyzed on a daily basis prior to clinical imaging. Uniformity images are traditionally analyzed using pixel value-based metrics which often fail to capture subtle structure and patterns caused by changes in gamma camera performance requiring additional visual inspection which is subjective and time demanding. The goal of this project was to develop and implement a robust QC metrology for NM that is effective in identifying non-uniformity issues, reporting issues in a timely manner for efficient correction prior to clinical involvement, all incorporated into an automated effortless workflow, and to characterize the program over a two year period. Methods: A new quantitative uniformity analysis metric was developed based on 2D noise power spectrum metrology and confirmed based on expert observer visual analysis. The metric, termed Structured Noise Index (SNI) was then integrated into an automated program to analyze, archive, and report on daily NM QC uniformity images. The effectiveness of the program was evaluated over a period of 2 years. Results: The SNI metric successfully identified visually apparent non-uniformities overlooked by the pixel valuebased analysis methods. Implementation of the program has resulted in nonuniformity identification in about 12% of daily flood images. In addition, due to the vigilance of staff response, the percentage of days exceeding trigger value shows a decline over time. Conclusion: The SNI provides a robust quantification of the NM performance of gamma camera uniformity. It operates seamlessly across a fleet of multiple camera models. The automated process provides effective workflow within the NM spectra between physicist, technologist, and clinical engineer. The reliability of this process has made it the preferred