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Sample records for sclerotic bone rim

  1. Sclerotic bone lesions at abdominal magnetic resonance imaging in children with tuberous sclerosis complex

    Energy Technology Data Exchange (ETDEWEB)

    Boronat, Susana [Massachusetts General Hospital, Department of Neurology, Boston, MA (United States); Universitat Autonoma de Barcelona, Department of Pediatric Neurology, Vall d' Hebron Hospital, Barcelona (Spain); Barber, Ignasi [Universitat Autonoma de Barcelona, Department of Pediatric Radiology, Vall d' Hebron Hospital, Barcelona (Spain); Pargaonkar, Vivek [Massachusetts General Hospital, Department of Radiology, Boston, MA (United States); Chang, Joshua; Thiele, Elizabeth A. [Massachusetts General Hospital, Department of Neurology, Boston, MA (United States)

    2016-05-15

    Sclerotic bone lesions are often seen on chest CT in adults with tuberous sclerosis complex. To characterize bone lesions at abdominal MRI in children with tuberous sclerosis complex. This retrospective review included 70 children with tuberous sclerosis complex who had undergone abdominal MRI for renal imaging. An additional longitudinal study was performed in 50 children who had had two or more MRI scans. Abdominal CT (eight children) and radiographs (three children) were reviewed and compared with MRI. A total of 173 sclerotic bone lesions were detected in 51/70 children (73%; 95% confidence interval: 0.61-0.82) chiefly affecting vertebral pedicles. New lesions appeared in 20 children and growth of previous sclerotic bone lesions was documented in 14 children. Sclerotic bone lesions were more frequent in girls and in children with more extensive renal involvement. Sclerotic bone lesions are commonly detected by abdominal MRI in children with tuberous sclerosis complex. They usually affect posterior vertebral elements and their number and size increase with age. As current recommendations for tuberous sclerosis complex surveillance include renal MR performed in childhood, recognition of these lesions is useful. (orig.)

  2. Evaluation of Response to Therapy in a Patient with Lung Cancer: Correlation of Sclerotic Bone Lesions with F 18 FDG PET/CT and Bone Scintigraphy

    Directory of Open Access Journals (Sweden)

    Filiz Özülker

    2011-04-01

    Full Text Available A 64-year-old male patient with small cell lung cancer underwent Fluorine-18 fluorodeoxyglucose (F 18 FDG positron emission tomography (PET/CT scan which revealed multiple F 18 FDG uptake in the spine, both humeri, ribs, pelvis and proximal long bones. There was no obvious lytic or sclerotic bone destruction accompanying these lesions on CT component of the study. After the patient received six courses of chemotherapy a repeat F 18 FDG-PET/CT was performed for evaluation of therapy response. The PET/CT showed the presence of multiple sclerotic lesions on CT without FDG uptake, corresponding to the bone lesions on the previous PET/CT scan. A concomitant Tc 99m Methylene diphosphonate (Tc 99m MDP bone scintigraphy (BS revealed no pathologically increased Tc 99m MDP uptake in the skeletal system. The FDG avid lesions in the skeletal system, which were not sclerotic initially, were transformed into FDG non-avid sclerotic lesions after chemotherapy. This was attributed to the direct effect of previous successful therapy for bone metastases, leading to the transformation of metabolically active disease, into blastic metabolically inactive metastases. In conclusion, a F 18 FDG negative bone lesion, which is sclerotic on CT, may represent post-treatment osteoblastic change rather than active tumor and BS might play a role in the discrimination of these two situations. (MIRT 2011; 20: 29-33

  3. Non-sclerotic bone involvement in Erdheim-Chester: PET/CT and MRI findings in a 15-year-old boy.

    Science.gov (United States)

    White, Theresa V; Silvester, Nicholas C; Otero, Hansel J

    2016-08-01

    Erdheim-Chester disease is a rare form of non-Langerhans cell histiocytosis with multi-organ infiltration that occurs mainly in adults. Pediatric cases are extremely rare. Here we report a case of multisystemic Erdheim-Chester disease in a 15-year-old boy with central nervous system involvement and skeletal findings. Positron emission tomography (PET) and MRI were used to demonstrate characteristic bilateral, symmetrical medullary involvement of the metadiaphyses of long bones in the absence of the classic sclerotic radiographic appearance. This illustrates the potential for earlier diagnosis and visualization of therapeutic response in children. PMID:27028532

  4. An Inflammatory Dentigerous Cyst Shows Rim Uptake on Bone Scan: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Son, Hye Joo; Jeong, Young Jin; Jeong, Jin Sook; Kang, Doyoung [Dong-A Univ. Medical Center, Busan (Korea, Republic of)

    2014-03-15

    Dentigerous cysts are developmental odontogenic jaw cysts, commonly manifesting in the 2nd and 3rd decades of life. This article presents an extremely rare case of dentigerous cyst showing increased uptake in the peripheral rim on bone scan. Herein, we discuss the clinical, radiographic, and histologic features of dentigerous cysts as well as the pathological mechanism underlying their activities on the bone scan. Bone scan was a sensitive tool for detecting the biologic activity of dentigerous cyst in our case.

  5. Do Bone Graft and Cracking of the Sclerotic Cavity Improve Fixation of Titanium and Hydroxyapatite-coated Revision Implants in an Animal Model?

    DEFF Research Database (Denmark)

    Elmengaard, Brian; Baas, Joergen; Jakobsen, Thomas;

    2016-01-01

    (crack, noncrack) using paired contralateral implants while implant surface (Ti6Al4V, HA) was qualitatively compared between the two (unpaired) series. All groups received bone allograft tightly packed around the implant. This revision model includes a cylindrical implant pistoning 500 μm in a 0.75-mm...... gap, with polyethylene particles, for 8 weeks. This engenders a bone and tissue response representative of the metaphyseal cancellous region of an aseptically loosened component. At 8 weeks, the original implants were revised and followed for an additional 4 weeks. Mechanical fixation was assessed...

  6. The effects of hydroxyapatite coating and bone allograft on fixation of loaded experimental primary and revision implants

    DEFF Research Database (Denmark)

    Søballe, Kjeld; Mouzin, Olivier R G; Kidder, Louis A;

    2003-01-01

    for the presence of particulate polyethylene. During this procedure, a sclerotic endosteal bone rim forms, and a dense fibrous membrane is engendered, having macrophages with ingested polyethylene and high levels of inflammatory cytokines. At the time of revision after 8 weeks, the cavity is revised with either...

  7. Genetic risk factors for sclerotic graft-versus-host disease.

    Science.gov (United States)

    Inamoto, Yoshihiro; Martin, Paul J; Flowers, Mary E D; Lee, Stephanie J; Carpenter, Paul A; Warren, Edus H; Geraghty, Daniel E; Lee, Ni; Boeckh, Michael J; Storer, Barry E; Levine, David M; Fan, Wenhong; Zhao, Lue-Ping; Hansen, John A

    2016-09-15

    Sclerotic graft-versus-host disease (GVHD) is a distinctive phenotype of chronic GVHD after allogeneic hematopoietic cell transplantation, characterized by fibrosis of skin or fascia. Sclerotic GVHD has clinical and histopathological similarities with systemic sclerosis, an autoimmune disease whose risk is influenced by genetic polymorphisms. We examined 13 candidate single-nucleotide polymorphisms (SNPs) that have a well-documented association with systemic sclerosis to determine whether these SNPs are also associated with the risk of sclerotic GVHD. The study cohort included 847 consecutive patients who were diagnosed with chronic GVHD. Genotyping was performed using microarrays, followed by imputation of unobserved SNPs. The donor rs10516487 (BANK1: B-cell scaffold protein with ankyrin repeats 1) TT genotype was associated with lower risk of sclerotic GVHD (hazard ratio [HR], 0.43; 95% confidence interval [CI], 0.21-0.87; P = .02). Donor and recipient rs2056626 (CD247: T-cell receptor ζ subunit) GG or GT genotypes were associated with higher risk of sclerotic GVHD (HR, 1.57; 95% CI, 1.13-2.18; P = .007 and HR, 1.66; 95% CI, 1.19-2.32; P = .003, respectively). Donor and recipient rs987870 (5'-flanking region of HLA-DPA1) CC genotypes were associated with higher risk of sclerotic GVHD (HR, 2.50; 95% CI, 1.22-5.11; P = .01 and HR, 2.13; 95% CI, 1.00-4.54; P = .05, respectively). In further analyses, the recipient DPA1*01:03∼DPB1*04:01 haplotype and certain amino acid substitutions in the recipient P1 peptide-binding pocket of the HLA-DP heterodimer were associated with risk of sclerotic GVHD. Genetic components associated with systemic sclerosis are also associated with sclerotic GVHD. HLA-DP-mediated antigen presentation, T-cell response, and B-cell activation have important roles in the pathogenic mechanisms of both diseases. PMID:27313329

  8. Ultraviolet A phototherapy for sclerotic skin diseases: a systematic review.

    NARCIS (Netherlands)

    Kroft, E.B.M.; Berkhof, N.J.; Kerkhof, P.C.M. van de; Gerritsen, R.M.; Jong, E.M.G.J. de

    2008-01-01

    BACKGROUND: Ultraviolet (UV) A-1 phototherapy is now available for a variety of skin diseases. Increasingly since 1995, there have been investigations of the efficacy of UVA-1 (340-400 nm) therapy for sclerotic skin diseases. Most studies undertaken treated patients who had localized scleroderma, bu

  9. T-tube insertion for sclerotic subglottic stenosis.

    Science.gov (United States)

    Goto, Taichiro; Kato, Ryoichi

    2014-02-01

    T-tube insertion is effective treatment for subglottic stenosis, but it is generally difficult due to bending of the T-tube. In a 52-year-old woman with relapsing polychondritis, a T-tube was inserted after predilatation using Hegar dilators. We describe the details of our T-tube insertion methods for sclerotic subglottic stenosis.

  10. Sclerotic Rings in Mosasaurs (Squamata: Mosasauridae): Structures and Taxonomic Diversity

    Science.gov (United States)

    Yamashita, Momo; Konishi, Takuya; Sato, Tamaki

    2015-01-01

    Mosasaurs (Squamata: Mosasauridae) were a highly diverse, globally distributed group of aquatic lizards in the Late Cretaceous (98–66 million years ago) that exhibited a high degree of adaptation to life in water. To date, despite their rich fossil record, the anatomy of complete mosasaur sclerotic rings, embedded in the sclera of the eyeball, has not been thoroughly investigated. We here describe and compare sclerotic rings of four mosasaur genera, Tylosaurus, Platecarpus, Clidastes, and Mosasaurus, for the first time. Two specimens of Tylosaurus and Platecarpus share an exact scleral ossicle arrangement, excepting the missing portion in the specimen of Platecarpus. Furthermore, the exact arrangement and the total count of 14 ossicles per ring are shared between Tylosaurus and numerous living terrestrial lizard taxa, pertaining to both Iguania and Scleroglossa. In contrast, two species of Mosasaurus share the identical count of 12 ossicles and the arrangement with each other, while no living lizard taxa share exactly the same arrangement. Such a mosaic distribution of these traits both among squamates globally and among obligatorily aquatic mosasaurs specifically suggests that neither the ossicle count nor their arrangement played major roles in the aquatic adaptation in mosasaur eyes. All the mosasaur sclerotic rings examined consistently exhibit aperture eccentricity and the scleral ossicles with gently convex outer side. Hitherto unknown to any squamate taxa, one specimen of Platecarpus unexpectedly shows a raised, concentric band of roughened surface on the inner surface of the sclerotic ring. It is possible that one or both of these latter features may have related to adaptation towards aquatic vision in mosasaurs, but further quantitative study of extant reptilian clades containing both terrestrial and aquatic taxa is critical and necessary in order to understand possible adaptive significances of such osteological features. PMID:25692667

  11. Sclerotic rings in mosasaurs (Squamata: Mosasauridae: structures and taxonomic diversity.

    Directory of Open Access Journals (Sweden)

    Momo Yamashita

    Full Text Available Mosasaurs (Squamata: Mosasauridae were a highly diverse, globally distributed group of aquatic lizards in the Late Cretaceous (98-66 million years ago that exhibited a high degree of adaptation to life in water. To date, despite their rich fossil record, the anatomy of complete mosasaur sclerotic rings, embedded in the sclera of the eyeball, has not been thoroughly investigated. We here describe and compare sclerotic rings of four mosasaur genera, Tylosaurus, Platecarpus, Clidastes, and Mosasaurus, for the first time. Two specimens of Tylosaurus and Platecarpus share an exact scleral ossicle arrangement, excepting the missing portion in the specimen of Platecarpus. Furthermore, the exact arrangement and the total count of 14 ossicles per ring are shared between Tylosaurus and numerous living terrestrial lizard taxa, pertaining to both Iguania and Scleroglossa. In contrast, two species of Mosasaurus share the identical count of 12 ossicles and the arrangement with each other, while no living lizard taxa share exactly the same arrangement. Such a mosaic distribution of these traits both among squamates globally and among obligatorily aquatic mosasaurs specifically suggests that neither the ossicle count nor their arrangement played major roles in the aquatic adaptation in mosasaur eyes. All the mosasaur sclerotic rings examined consistently exhibit aperture eccentricity and the scleral ossicles with gently convex outer side. Hitherto unknown to any squamate taxa, one specimen of Platecarpus unexpectedly shows a raised, concentric band of roughened surface on the inner surface of the sclerotic ring. It is possible that one or both of these latter features may have related to adaptation towards aquatic vision in mosasaurs, but further quantitative study of extant reptilian clades containing both terrestrial and aquatic taxa is critical and necessary in order to understand possible adaptive significances of such osteological features.

  12. Fiber composite flywheel rim

    Science.gov (United States)

    Davis, Donald E.; Ingham, Kenneth T.

    1987-01-01

    A flywheel 2 comprising a hub 4 having at least one radially projecting disc 6, an annular rim 14 secured to said disc and providing a surface circumferential to said hub, a first plurality of resin-impregnated fibers 22 wound about said rim congruent to said surface, and a shell 26 enclosing said first plurality of fibers and formed by a second plurality of resin-impregnated fibers wound about said rim tangentially to said surface.

  13. [Chondromyxoid fibroma of bone: a rare benign bone tumor in children].

    Science.gov (United States)

    Rouas, L; Malihy, A; Cherradi, N; Lamalmi, N; Alhamany, Z

    2004-12-01

    Chondromyxoid fibroma is a rare benign tumor that is typically found in the metaphyseal ends of long tubular bones, such as the tibia. The radiographic appearances are those of a single, lytic lesion with lobulated margins, septations, cortical expansion and a sclerotic rim. The classic histological feature of a chondromyxoid fibroma is stellate or spindle-shaped cells arranged in lobules in a myxoid or chondroid background. Two cases are presented here: 8, and 12-year-old patients, both with lesions in the proximal tibia. The first case showed an unusual feature: it was diaphyseal chondromyxoid fibroma. In the second case, the lesion was metaphyso-diaphyseal. The differential diagnosis includes chondroblastoma, myxoma, aneurysmal cyst as well as chondrosarcoma. A surgical conservative treatment with complete excision is recommended even in case of recurrence. PMID:15688891

  14. Indian Ocean Rim Cooperation

    DEFF Research Database (Denmark)

    Wippel, Steffen

    Since the mid-1990s, the Indian Ocean has been experiencing increasing economic cooperation among its rim states. Middle Eastern countries, too, participate in the work of the Indian Ocean Rim Association, which received new impetus in the course of the current decade. Notably Oman is a very active...

  15. Dopamine-Mediated Sclerotization of Regenerated Chitin in Ionic Liquid

    Directory of Open Access Journals (Sweden)

    Dongyeop X. Oh

    2013-09-01

    Full Text Available Chitin is a promising structural material for biomedical applications, due to its many advantageous properties and abundance in nature. However, its usage and development in the biomedical field have been stagnant, because of chitin’s poor mechanical properties in wet conditions and the difficulties in transforming it into an applicable form. To overcome these challenges, we created a novel biomimetic chitin composite. This regenerated chitin, prepared with ionic liquid, showed improved mechanical properties in wet conditions by mimicking insect cuticle and squid beak sclerotization, i.e., catechol-meditated cross-linking. By ionic liquid-based heat treatment, dopamine oxidation produced melanin-like compounds and dopamine-meditated cross-links without any solvent evaporation and oxidant utilization. The dopamine-meditated sclerotization increased the ultimate tensile strength (UTS of the regenerated chitin by 2.52-fold, measured after six weeks of phosphate-buffered saline (PBS submersion. In addition, the linear swelling ratio (LSR of the chitin film was reduced by about 22%. This strategy raises a possibility of using regenerated chitin as an artificial hard tissue in wet conditions.

  16. Multifocal sclerotic BCG spondylitis in a 13-year-old girl

    International Nuclear Information System (INIS)

    A case is reported of multifocal BCG osteomyelitis in a 13-year-old girl. The lesions in the skull, ribs and in several vertebrae were mainly sclerotic and healed with antituberculotic therapy. The case is unusual because of the late onset, sclerotic changes, and involvement of the spine. (orig.)

  17. Postecdysis Sclerotization of Mouthparts of the Formosan Subterranean Termites (Isoptera: Rhinotermitidae).

    Science.gov (United States)

    Kakkar, Garima; Chouvenc, Thomas; Su, Nan-Yao

    2016-04-01

    In termites, it is challenging to recognize the incidence of molting in workers because of their successive stationary molt, asynchronous molting among individuals, cryptic behavior, a soft and poorly sclerotized cuticle, and they immediately consume the shed exuvia of nestmates. This study describes a method in which the degree of sclerotization of the mouthparts in newly molted workers of the Formosan subterranean termite can be quantified and used to determine if an individual has recently molted, within a 36-h time frame. Changes in the tanning of mouthparts over time were used as a measure of the index of sclerotization in workers postmolting. Upon ecdysis, the primary point of articulation of the mandible already initiated sclerotization, which may allow the movement of the mandibles during the shedding of the exuvium. The sclerotization of the secondary point of articulation and the mandibular teeth, and the width of sclerotization of the mandibles, progressively increased until reaching a plateau around 36-h postecdysis, which imply that workers can regain some level of activity as early as 2 d after ecdysis. Our observations allowed for the determination of variables for the sclerotization of the mouthparts to easily identify workers that recently molted, and this method will be useful in future studies that focus on the molting activity of workers over time and space within a termite colony, in the scope of improving current control strategies for termite pests. PMID:26743216

  18. 激素性股骨头坏死硬化带与骨形态蛋白关系的研究%Study on the relationship between sclerosis rim and bone morphogenetic proteins of osteonecrosis of the femoral head

    Institute of Scientific and Technical Information of China (English)

    石少辉; 李子荣; 王佰亮; 孙伟; 程立明; 潘琳; 王冉东

    2010-01-01

    目的 通过对股骨头坏死(ONFH)患者硬化带形成情况进行回顾性分析及其组织学观察,探讨骨形态蛋白(BMP4)与硬化带关系,为股骨头坏死个性化治疗提供理论依据.方法 2005年11月至2007年11月共治疗激素性ONFH全髋关节置换患者184髋,患者平均年龄(47±7)岁,依此把患者分为高(>54岁)、中(40~54岁)和低(<40岁)3个年龄组,分析比较3组患者硬化带形成比率.从184髋中选取部分股骨头标本,包括高年龄组患者股骨头18髋,低年龄组11髋,中年龄组股骨头标本20髋(有无硬化带形成者各10髋).股骨头冠状面正中剖开,在负重区和非负重区取材,行常规HE染色、苦味酸-天狼星红染色、电镜制备和BMP4蛋白免疫组化染色.BMP4蛋白免疫组化染色强度用图像分析软件计算其平均光密度.结果 硬化带在组织学上表现为骨小梁增粗,结构紊乱,但骨细胞结构同正常骨细胞,且处于高分泌状态.中年龄组ONFH患者硬化带形成比例为71.4%(105/147),显著高于低年龄组患者(45.5%,5/11)和高年龄组患者(38.5%,10/26)(P均<0.01).中年组患者股骨头BMP4平均光密度为0.32±0.14,明显高于低年龄组0.20±0.17和高年龄组0.19±0.27,且差异具有统计学意义(P均<0.05);中年龄组患者无硬化带形成者BMP4平均光密度分别为0.16±0.1l,有硬化带形成患者为0.28±0.13,差异具有统计学意义(P<0.01).有硬化带形成患者出现髋关节疼痛到关节置换时间为(49±11)个月,显著长于无硬化带形成者(15±2)个月,差异具有统计学意义(P<0.01).结论 ONFH患者硬化带形成与BMP4表达强弱呈正相关,BMP的高表达可能促进硬化带的形成.%Objectives To analyze retrospectively the formation and histological changes of sclerosis rim in patients with osteonecrosis of the femoral head ( ONFH), and to study the relationship between bone morphogenetic proteins (BMP4) and sclerosis rim, so as to acquire

  19. RIMS Program Description.

    Science.gov (United States)

    Kraepelien, Hans

    Computer routines for the translation of teacher-prepared mark sense forms to magnetic tape are described. The program, Receiving IMS (RIMS), is part of the Southwest Regional Laboratory's (SWRL) Instructional Management System (IMS). It accepts mark sense sheets from remotely located Xerox 660 scanner copiers and/or IMS update information from…

  20. Optimization Of Car Rim

    Directory of Open Access Journals (Sweden)

    Mr. Sushant K. Bawne

    2015-10-01

    Full Text Available The essential of car wheel rim is to provide a firm base on which to fit the tyre. Its dimensions, shape should be suitable to adequately accommodate the particular tyre required for the vehicle. In this project a tyre of car wheel rim belonging to the disc wheel category is considered. Design is an important industrial activity which influences the quality of the product. The wheel rim is modeled by using modeling software catiav5r17. By using this software the time spent in producing the complex 3- D models and the risk involved in the design and manufacturing process can be easily minimized. So the modeling of the wheel rim is made by using CATIA. Later this CATIA modal is imported to ANSYS WORKBENCH 14.5 for analysis work. ANSYS WORKBENCH 14.5 is the latest software used for simulating the different forces, pressure acting on the component and also calculating and viewing the results. By using ANSYS WORKBENCH 14.5 software reduces the time compared with the method of mathematical calculations by a human. ANSYS WORKBENCH 14.5 static structural analysis work is carried out by considered three different materials namely aluminum alloy ,magnesium alloy and structural steel and their relative performances have been observed respectively. In addition to wheel rim is subjected to modal analysis, a part of dynamic analysis is carried out its performance is observed. In this analysis by observing the results of both static and dynamic analysis obtained magnesium alloy is suggested as best material.

  1. Preliminary Results on the Feasibility of Using ARFI/SWEI to Assess Cutaneous Sclerotic Diseases.

    Science.gov (United States)

    Lee, Seung Yun; Cardones, Adela R; Doherty, Joshua; Nightingale, Kathryn; Palmeri, Mark

    2015-11-01

    In this study, acoustic radiation force impulse (ARFI) and shear wave elasticity imaging (SWEI) were applied to the skin to investigate the feasibility of their use in assessing sclerotic skin diseases. Our motivation was to develop a non-invasive imaging technology with real-time feedback of sclerotic skin disease diagnosis. This paper shows representative results from an ongoing study, recruiting patients with and without sclerosis. The stiffness of the imaged site was evaluated using two metrics: mean ARFI displacement magnitude and bulk shear wave speed inside the region of interest (ROI). In a subject with localized graft versus host disease (GVHD), the mean ARFI displacement inside sclerotic skin was 61% lower (p types. We conclude ARFI and SWEI can successfully differentiate sclerotic lesions from normal dermis. PMID:26259888

  2. Effect of Induced Refractive Error and Nuclear Sclerotic Cataracts on Ishihara Colour Plate Testing

    OpenAIRE

    Eneh AA; Rogalska T; Urton T; Schweitzer KD

    2014-01-01

    Objective: To determine the effect of induced refractive blur and nuclear sclerotic (NS) cataracts on Ishihara colour plate (ICP) scores. Design: Prospective evaluation of a diagnostic test Participants: Patients who presented to Hotel Dieu Hospital Eye clinic between January and March 2010 with either a lone diagnosis of nuclear sclerotic cataracts, or with no identified ocular disease with complete examination. Methods: Patients were divided into two groups: those having no id...

  3. RIMS: Resource Information Management System

    Science.gov (United States)

    Symes, J.

    1983-01-01

    An overview is given of the capabilities and functions of the resource management system (RIMS). It is a simple interactive DMS tool which allows users to build, modify, and maintain data management applications. The RIMS minimizes programmer support required to develop/maintain small data base applications. The RIMS also assists in bringing the United Information Services (UIS) budget system work inhouse. Information is also given on the relationship between the RIMS and the user community.

  4. Metabolic analysis of osteoarthritis subchondral bone based on UPLC/Q-TOF-MS.

    Science.gov (United States)

    Yang, Gang; Zhang, Hua; Chen, Tingmei; Zhu, Weiwen; Ding, Shijia; Xu, Kaiming; Xu, Zhongwei; Guo, Yanlei; Zhang, Jian

    2016-06-01

    Osteoarthritis (OA), one of the most widespread musculoskeletal joint diseases among the aged, is characterized by the progressive loss of articular cartilage and continuous changes in subchondral bone. The exact pathogenesis of osteoarthritis is not completely clear. In this work, ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS) in combination with multivariate statistical analysis was applied to analyze the metabolic profiling of subchondral bone from 42 primary osteoarthritis patients. This paper described a modified two-step method for extracting the metabolites of subchondral bone from primary osteoarthritis patients. Finally, 68 metabolites were identified to be significantly changed in the sclerotic subchondral bone compared with the non-sclerotic subchondral bone. Taurine and hypotaurine metabolism and beta-alanine metabolism were probably relevant to the sclerosis of subchondral bone. Taurine, L-carnitine, and glycerophospholipids played a vital regulation role in the pathological process of sclerotic subchondral bone. In the sclerotic process, beta-alanine and L-carnitine might be related to the increase of energy consumption. In addition, our findings suggested that the intra-cellular environment of sclerotic subchondral bone might be more acidotic and hypoxic compared with the non-sclerotic subchondral bone. In conclusion, this study provided a new insight into the pathogenesis of subchondral bone sclerosis. Our results indicated that metabolomics could serve as a promising approach for elucidating the pathogenesis of subchondral bone sclerosis in primary osteoarthritis. Graphical Abstract Metabolic analysis of osteoarthritis subchondral bone. PMID:27074781

  5. CUTANEOUS MYXOID CYST ON THE SCLEROTIC FINGER IN A PATIENT WITH DIFFUSE SYSTEMIC SCLEROSIS

    Directory of Open Access Journals (Sweden)

    Taeko Nakamura-Wakatsuki

    2013-10-01

    Full Text Available Skin tumors occurring on the scleroderma fingers are rarely seen. Swollen fingers are hallmarks of systemic sclerosis, and mucin deposition in the lesional skin is a constant feature in systemic sclerosis. Here we describe a case of cutaneous myxoid cyst on the flexor aspect of the sclerotic fingers in a patient with severe diffuse cutaneous systemic sclerosis. Cutaneous myxoid cyst is a relatively common benign tumor; however, cases of cutaneous myxoid cysts developing on the scleroderma fingers have not been reported to date. Mucin deposition in the sclerotic skin may be a predisposing factor in the induction of myxoid cyst on the scleroderma finger in our patient.

  6. Minocycline-induced orbital rim discoloration.

    Science.gov (United States)

    Ballard, Tiffany N S; Briceño, César A

    2016-04-01

    A 20-year-old woman underwent lacrimal gland biopsy for unilateral swelling and was unexpectedly found to have olive-green discoloration of her orbital rim. Postoperative questioning revealed that as a teenager she had been treated for acne with minocycline, a semisynthetic tetracycline antibiotic and a first-line treatment for moderate and severe acne. While hyperpigmentation is a known side effect of minocycline, reports of pigmentation changes of the periorbital bones are relatively rare and could pose a diagnostic dilemma during surgery. PMID:26988772

  7. Ossicular bone modeling in acute otitis media

    DEFF Research Database (Denmark)

    Salomonsen, Rasmus Lysholdt; Hermansson, Ann; Cayé-Thomasen, Per

    2010-01-01

    A number of middle ear diseases are associated with pathologic bone modeling, either formative or resorptive. As such, the pathogenesis of a sclerotic mastoid has been controversial for decades. Experimental studies on acute middle ear infection have shown progressive osteoneogenesis in the bone ...

  8. 1例硬化性滑膜肉瘤的临床病理观察%Clinicopathological features of sclerotic synovial sarcoma

    Institute of Scientific and Technical Information of China (English)

    王昀; 王殿军; 贾金鹏

    2012-01-01

    , desmin and SMA. P53 positive cells accounted for 50%-75%. Reticulum fibers in sclerotic interstitial area were positively stained with AB while PAS staining was negative. FISH showed SS18(18qll.2) chromosome translocation. Conclusion Sclerotic SS is an extremely rare type of synovial sarcoma. Its differential diagnosis can be made with immunohistochemical staining and molecular detection from parosteal osteosarcoma, myositis ossificans, fibrosarcoma, desmoplastic fibroma of bone and hemangiopericytoma.

  9. Portable basketball rim testing device

    Science.gov (United States)

    Abbott, W. Bruce; Davis, Karl C.

    1993-01-01

    A portable basketball rim rebound testing device 10 is illustrated in two preferred embodiments for testing the rebound or energy absorption characteristics of a basketball rim 12 and its accompanying support to determine likely rebound or energy absorption charcteristics of the system. The apparatus 10 includes a depending frame 28 having a C-clamp 36 for releasably rigidly connecting the frame to the basketball rim 12. A glide weight 60 is mounted on a guide rod 52 permitting the weight 60 to be dropped against a calibrated spring 56 held on an abutment surface on the rod to generate for deflecting the basketball rim and then rebounding the weight upwardly. A photosensor 66 is mounted on the depending frame 28 to sense passage of reflective surfaces 75 on the weight to thereby obtain sufficient data to enable a processing means 26 to calculate the rebound velocity and relate it to an energy absorption percentage rate of the rim system 12. A readout is provided to display the energy absorption percentage.

  10. Bone

    Science.gov (United States)

    Helmberger, Thomas K.; Hoffmann, Ralf-Thorsten

    The typical clinical signs in bone tumours are pain, destruction and destabilization, immobilization, neurologic deficits, and finally functional impairment. Primary malignant bone tumours are a rare entity, accounting for about 0.2% of all malignancies. Also benign primary bone tumours are in total rare and mostly asymptomatic. The most common symptomatic benign bone tumour is osteoid osteoma with an incidence of 1:2000.

  11. The Sclerotic Scatter Limbal Arc Is More Easily Elicited under Mesopic Rather Than Photopic Conditions.

    Directory of Open Access Journals (Sweden)

    Eric Denion

    Full Text Available We aimed to determine the limbal lighting illuminance thresholds (LLITs required to trigger perception of sclerotic scatter at the opposite non-illuminated limbus (i.e. perception of a light limbal scleral arc under different levels of ambient lighting illuminance (ALI.Twenty healthy volunteers were enrolled. The iris shade (light or dark was graded by retrieving the median value of the pixels of a pre-determined zone of a gray-level iris photograph. Mean keratometry and central corneal pachymetry were recorded. Each subject was asked to lie down, and the ALI at eye level was set to mesopic values (10, 20, 40 lux, then photopic values (60, 80, 100, 150, 200 lux. For each ALI level, a light beam of gradually increasing illuminance was applied to the right temporal limbus until the LLIT was reached, i.e. the level required to produce the faint light arc that is characteristic of sclerotic scatter at the nasal limbus.After log-log transformation, a linear relationship between the logarithm of ALI and the logarithm of the LLIT was found (p<0.001, a 10% increase in ALI being associated with an average increase in the LLIT of 28.9%. Higher keratometry values were associated with higher LLIT values (p = 0.008 under low ALI levels, but the coefficient of the interaction was very small, representing a very limited effect. Iris shade and central corneal thickness values were not significantly associated with the LLIT. We also developed a censored linear model for ALI values ≤ 40 lux, showing a linear relationship between ALI and the LLIT, in which the LLIT value was 34.4 times greater than the ALI value.Sclerotic scatter is more easily elicited under mesopic conditions than under photopic conditions and requires the LLIT value to be much higher than the ALI value, i.e. it requires extreme contrast.

  12. Datasets from label-free quantitative proteomic analysis of human glomeruli with sclerotic lesions

    Directory of Open Access Journals (Sweden)

    Ying Zhang

    2015-09-01

    Full Text Available Human glomeruli with intermediate (i-GS and advanced (GS sclerotic lesions as well as the normal control (Nor were captured from laser microdissection, digested by trypsin and subjected to shotgun LC-MS/MS analysis (LTQ-Orbitrap XL. The label-free quantification was performed using the Normalized Spectral Index (SIN to assess the relative molar concentration of each protein identified in a sample. All the experimental data are shown in this article. The data is associated to the research article submitted to Journal of Proteomics [1].

  13. Bone

    International Nuclear Information System (INIS)

    Bone scanning provides information on the extent of primary bone tumors, on possible metastatic disease, on the presence of osteomyelitis prior to observation of roentgenographic changes so that earlier therapy is possible, on the presence of collagen diseases, on the presence of fractures not disclosed by x-ray films, and on the evaluation of aseptic necrosis. However, the total effect and contribution of bone scanning to the diagnosis, treatment, and ultimate prognosis of pediatric skeletal diseases is, as yet, unknown. (auth)

  14. Adaptation of subchondral bone in osteoarthritis

    DEFF Research Database (Denmark)

    Ding, Ming

    2004-01-01

    never been proven. Recent studies showing reduced chemical and mechanical properties of subchondral bone in various stages of the disease have invigorated interest in the role of subchondral bone in the development and progression of the disease. The current study showed that the concept of bone...... adaptation might explain subchondral stiffening, a process where subchondral bone becomes typically sclerotic in osteoarthritis. In addition, we report reduced mechanical matrix tissue properties as well as an increase in denatured collagen content. In conclusion, although osteoarthritic bone tissue contains...... increased denatured collagen and has reduced matrix mechanical properties, the widely accepted concept of subchondral stiffening is compatible with the process of normal bone adaptation. Udgivelsesdato: 2004...

  15. Systematic Identification, Characterization and Target Gene Analysis of microRNAs Involved in Osteoarthritis Subchondral Bone Pathogenesis.

    Science.gov (United States)

    Prasadam, Indira; Batra, Jyotsna; Perry, Samuel; Gu, Wenyi; Crawford, Ross; Xiao, Yin

    2016-07-01

    This study aimed to identify the microRNAs associated with sclerotic status of subchondral bone in the pathogenesis of osteoarthritis (OA). Total RNA was extracted from non-sclerotic and sclerotic OA subchondral bone from patients undergoing knee replacement surgeries. miRCURY™ LNA miRNA chip and qRT-PCR were used to profile and validate differential microRNA expression. In addition, we further confirmed profiles of altered miRNAs in an OA rat meniscectomy animal model and their putative targets of the miRNAs were predicted using ingenuity (IPA) software. Finally, five short-listed miRNAs were reactivated by transient in vitro overexpression (miRNA mimics) in subchondral bone osteoblasts and their phenotypes were assessed. Functional screening identified 30 differentiated miRNAs in sclerotic subchondral bone compared to non-sclerotic bone of OA patients. Data integration resulted in confirmation of the eight miRNAs, with aberrant expression in independent human OA bone sample set. In silico analysis (IPA) identified 732 mRNA transcripts as putative targets of the eight altered miRNAs, of which twenty genes were validated to be differentially expressed in sclerotic compared to non-sclerotic bone samples. Out of eight dysregulated miRNA's, five of them showed consistent time-dependent downregulation in a rat OA model. Furthermore, synthetic miR-199a-3p, miR-199a-5p, miR-590-5p, and miR-211-5p mimics rescued the abnormal osteoarthritic subchondral bone osteoblast gene expression and mineralization. We have identified four novel miRNAs that play important roles in subchondral bone pathogenesis in OA. Additional studies are required to develop these miRNAs into therapeutic modalities for OA. PMID:26944279

  16. Imaging appearance of bone tumors of the maxillofacial region

    OpenAIRE

    Razek, Ahmed Abdel Khalek Abdel

    2011-01-01

    This paper reviews the imaging appearance of benign and malignant bone tumors of the maxillofacial region. A benign bone tumor commonly appears as a well circumscribed lesion. The matrix of the tumor may be calcified or sclerotic. Malignancies often display aggressive characteristics such as cortical breakthrough, bone destruction, a permeative pattern and associated soft-tissue masses. Computed tomography scan is an excellent imaging modality for accurate localization of the lesion, characte...

  17. Antifibrotic effects of crocetin in scleroderma fibroblasts and in bleomycin-induced sclerotic mice

    Directory of Open Access Journals (Sweden)

    Yinghua Song

    2013-10-01

    Full Text Available OBJECTIVE: To investigate the antifibrotic effects of crocetin in scleroderma fibroblasts and in sclerotic mice. METHODS: Skin fibroblasts that were isolated from three systemic scleroderma (SSc patients and three healthy subjects were treated with crocetin (0.1, 1 or 10 μM. Cell proliferation was measured with an MTT assay. Alpha-smooth muscle actin was detected via an immunohistochemical method. Alpha 1 (I procollagen (COL1A1, alpha 1 (III procollagen (COL3A1, matrix metalloproteinase (MMP-1 and tissue inhibitor of matrix metalloproteinase (TIMP-1 mRNA levels were measured using real-time PCR. SSc mice were established by the subcutaneous injection of bleomycin. Crocetin (50 mg/kg/d was injected intraperitoneally for 14 days. Dermal thickness and lung fibrosis were assessed with Masson's trichrome staining. Plasma ET-1 was detected with an enzyme-linked immunosorbent assay (ELISA. Skin and lung ET-1 and COL1A1 mRNA levels were measured via real-time PCR. RESULTS: Crocetin inhibited the proliferation of SSc and normal fibroblasts, an effect that increased with crocetin concentration and incubation time. Crocetin decreased the expression of α-SMA and the levels of mRNA for COL1A1, COL3A1 and matrix metalloproteinase-1, while crocetin increased TIMP-1 mRNA levels in both SSc and normal fibroblasts. Skin and lung fibrosis was induced, and the levels of ET-1 in the plasma, skin and lungs were elevated in bleomycin-injected mice. Crocetin alleviated the thickening of the dermis and lung fibrosis; decreased COL1A1 mRNA levels in the skin and lung; and simultaneously decreased ET-1 concentrations in the plasma and ET-1 mRNA levels in the skin and lungs of the bleomycin-induced sclerotic mice, especially during the early phase (weeks 1-3. CONCLUSION: Crocetin inhibits cell proliferation, differentiation and collagen production in SSc fibroblasts. Crocetin alleviates skin and lung fibrosis in a bleomycin-induced SSc mouse model, in part due to a

  18. Thermoviscous Coating and Rimming Flow

    KAUST Repository

    Leslie, G. A.

    2012-10-22

    A comprehensive description is obtained of steady thermoviscous (that is, with temperature-dependent viscosity) coating and rimming flow of a thin film of fluid on a uniformly rotating horizontal cylinder that is uniformly hotter or colder than the surrounding atmosphere. It is found that, as in the corresponding isothermal problem, there is a critical solution with a corresponding critical load (which depends, in general, on both the Biot number B and the thermoviscosity number V) above which no \\'full-film\\' solutions corresponding to a continuous film of fluid covering the entire outside or inside of the cylinder exist. The effect of thermoviscosity on both the critical solution and the full-film solution with a prescribed load is described. In particular, there are no full-film solutions with a prescribed load M for any value of B when for positive V and when M ≥ f-1/2 Mc0 for negative V, where is a monotonically decreasing function of V and M c0 ≃ 4.44272 is the critical load in the constant-viscosity case. It is also found that, for the exponential viscosity model, when the prescribed load satisfies M < 1.50315 there is a narrow region of the B-V parameter plane in which backflow occurs. © 2012 The Author. Published by Oxford University Press; all rights reserved. For Permissions, please email: journals.permissions@oup.com.

  19. Association Between the Proportion of Sclerotic Glomeruli and Serum Creatinine in Primary Focal Segmental Glomerulosclerosis

    Directory of Open Access Journals (Sweden)

    Ashraf FAKHRJOU

    2012-05-01

    Full Text Available Objective: To evaluate the possible correlation between the extent of sclerotic glomeruli and the level of serum creatinine and its clearance rate in patients with primary focal segmental glomerolusclerosis.Material and Method: In a cross-sectional study, 50 patients with biopsy-proven primary focal segmental glomerolusclerosis were recruited. The proportion of globally and segmentally sclerosed glomeruli was determined during the first histopathological examination of renal biopsy specimens. Correlations of these variables with on admission serum level of creatinine and its clearance rate were investigated.Results: Twenty-four males and 26 females with a mean age of 39.82±16.45 (range: 16-85 years were enrolled in the study. In a significant fashion, the proportions of segmental and global glomerulosclerosis were directly correlated with the serum level of creatinine and inversely with its clearance rate (r=-0.43 with p=0.002 and r=-0.45 with p=0.001, respectively.Conclusion: Apart from the degree of interstitial fibrosis, the serum level of creatinine and its clearance rate are well correlated with the proportions of both segmentally and globally sclerosed glomeruli in primary focal segmental glomerulosclerosis.

  20. Beyond the peak of the anterior glenoid rim: A cadaveric study

    Directory of Open Access Journals (Sweden)

    Guillaume D Dumont

    2013-01-01

    Full Text Available Purpose: The purpose of this study was to quantify the width of bone beyond the peak of the anterior glenoid rim and to determine if this anatomic region of the glenoid significantly affects measurement of the anteroposterior glenoid diameter. Materials and Methods: 19 cadaveric scapulae were examined and the width of bone beyond the peak of the anterior glenoid rim was measured. The percent width of this region relative to the anteroposterior diameter of the glenoid was evaluated. Male and female specimens were compared. Measurements of the anteroposterior diameter of the glenoid, both including and excluding this region, were compared. Results: The mean width of bone beyond the peak of the anterior glenoid rim was 3.2 ± 0.7 mm, corresponding to 10.5% of the anteroposterior glenoid diameter. This anatomic region is of similar relative size in males and females (11% vs 10% of the glenoid diameter. Measurement of the anteroposterior diameter of the glenoid is significantly different depending on whether this region is included or not ( P = 0.0064. Conclusions: There exists a portion of the anterior glenoid that is beyond the peak of the anterior rim, and is not part of the concave articular surface. The width of this anatomic area comprises a significant percent of the anteroposterior glenoid diameter, and should be understood when quantifying and describing anterior glenoid bone loss in cases of glenohumeral instability. Clinical Relevance: Understanding of anterior glenoid anatomy is important in the evaluation of glenohumeral instability. The portion of glenoid bone beyond the anterior rim peak is likely important for its soft tissue attachments, but its contribution to bony stability may be misunderstood.

  1. How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs.

    Science.gov (United States)

    Acuna, Claudio; Liu, Xinran; Südhof, Thomas C

    2016-08-17

    RIMs and RIM-binding proteins (RBPs) are evolutionary conserved multidomain proteins of presynaptic active zones that are known to recruit Ca(2+) channels; in addition, RIMs perform well-recognized functions in tethering and priming synaptic vesicles for exocytosis. However, deletions of RIMs or RBPs in mice cause only partial impairments in various active zone functions and have no effect on active zone structure, as visualized by electron micrographs, suggesting that their contribution to active zone functions is limited. Here, we show in synapses of the calyx of Held in vivo and hippocampal neurons in culture that combined, but not individual, deletions of RIMs and RBPs eliminate tethering and priming of synaptic vesicles, deplete presynaptic Ca(2+) channels, and ablate active zone complexes, as analyzed by electron microscopy of chemically fixed synapses. Thus, RBPs perform unexpectedly broad roles at the active zone that together with those of RIMs are essential for all active zone functions. PMID:27537484

  2. Oscillating Rim Hook Tableaux and Colored Matchings

    CERN Document Server

    Chen, William Y C

    2011-01-01

    Motivated by the question of finding a type B analogue of the bijection between oscillating tableaux and matchings, we find a correspondence between oscillating m-rim hook tableaux and m-colored matchings, where m is a positive integer. An oscillating m-rim hook tableau is defined as a sequence $(\\lambda^0,\\lambda^1,...,\\lambda^{2n})$ of Young diagrams starting with the empty shape and ending with the empty shape such that $\\lambda^{i}$ is obtained from $\\lambda^{i-1}$ by adding an m-rim hook or by deleting an m-rim hook. Our bijection relies on the generalized Schensted algorithm due to White. An oscillating 2-rim hook tableau is also called an oscillating domino tableau. When we restrict our attention to two column oscillating domino tableaux of length 2n, we are led to a bijection between such tableaux and noncrossing 2-colored matchings on $\\{1, 2,..., 2n\\}$, which are counted by the product $C_nC_{n+1}$ of two consecutive Catalan numbers. A 2-colored matching is noncrossing if there are no two arcs of th...

  3. Histologia e ultraestrutura do rim e rim cefálico do pacu

    Directory of Open Access Journals (Sweden)

    Gerlane M. Costa

    2012-05-01

    Full Text Available O pacu, Piaractus mesopotamicus, é um teleósteo da Família Characidae, intensivamente cultivado no Brasil devido sua rusticidade, crescimento rápido e fácil adaptação. O conhecimento morfológico dos sistemas corpóreos, incluído órgãos linfóide, se faz necessário, para uma melhor produção no cultivo de peixes, fornecendo subsídios na manutenção dos estoques. O objetivo deste estudo foi descrever morfologicamente o rim e rim cefálico de Piaractus mesopotamicus, analisando os perfis celulares de cada órgão com o uso de microscopia de luz e microscopia eletrônica de transmissão. O resultado da análise macroscópica mostrou que a localização do rim e rim cefálico são as mesmas encontradas na maioria dos teleósteos. O rim apresentou uma forma em "H", onde a região média se expandia sobre a bexiga natatória. O rim cefálico se apresentou como uma dilatação na região cranial do rim, mostrando-se bem visível. Na microscopia eletrônica de transmissão também foram observadas similaridades ultraestruturais com outros teleósteos. Observando nossos resultados concluímos que histologicamente e ultraestruturalmente, os órgãos linfóides rim e rim cefálico de Piaractus mesopotamicus são similares aos de outros teleósteos.

  4. Echogenic rim of hepatic hemangioma on abdominal ultrasound

    International Nuclear Information System (INIS)

    To investigate the association between the size of the hepatic hemangioma and the shape and thickness of the echogenic rim of hepatic hemangioma on abdominal ultrasound. We examined 47 cases (M:F=24:23, mean age 47.1) of hepatic hemangiomas with echogenic rim on abdominal ultrasound during the past 2 years. Radiologic findings were retrospectively reviewed in terms of completeness and thickness of echogenic rim. If echogenic rim showed even thickness, it was measured. But if not, the maximum and minimum thickness of the rim was measured. The association between the size of hemangioma and the completeness and thickness of the echogenic rim were analyzed statistically. Of the 47 cases, complete echogenic rim and incomplete echogenic rim were obtained in 29 (62%) and 18 (38%) cases, respectively. Twenty-two cases of hemangioma were less than 2 cm in diameter, and their distribution according to echogenic rim were as follows: complete echogenic rim (17/20, 91% mean thickness 2.2 cm) and uneven thickness with complete echogenic rim (3/20, 15%, range:2.0-6.1 mm). Twenty-five hemangiomas were larger than 2 cm in diameter and their distribution according to echogenic rim were as follows: complete echogenic rim (n=9, 34%), incomplete echogenic rim (n=16, 64%0,even thickness with complete echogenic rim (3/9, 33%, mean thickness 2.2 mm) and uneven thickness with complete echogenic rim (6/9,67%, range: 2.0-7.6 mm). In statistical analysis, hemangiomas more than 2 cm in diameter were more likely to have incomplete echogenic rim (p<0.05) than those of less than 2 cm; hemangiomas more than with more than 2 cm in diameter and complete echogenic rim showed uneven thickness of echogenic rim (p<0.05), more often than those of less than 2 cm diameter. Hemangiomas with more than 2 cm in diameter showed more frequent incomplete echogenic rim than those of less than 2 cm in diameter, which had more frequent complete echogenic rim. Hemangiomas with complete echogenic rim and even rim

  5. Rim-spoke composite flywheels: Stress and vibration analysis

    Science.gov (United States)

    Chamis, C. C.; Kiraly, L. J.

    1976-01-01

    Elementary relations are described to determine the material utilization efficiency of a thin wall rim composite flywheel over other configurations. An algorithm is generated for the automatic selection of the optimum composite material for a given thin rim flywheel environment. Subsequently, the computer program NASTRAN is used to perform a detailed stress and vibration analysis of thin wall cylindrical shell rim spoke, single rim and multirim composite flywheels for a specific application.

  6. The Articulated Alar Rim Graft: Reengineering the Conventional Alar Rim Graft for Improved Contour and Support.

    Science.gov (United States)

    Ballin, Annelyse C; Kim, Haena; Chance, Elizabeth; Davis, Richard E

    2016-08-01

    Surgical refinement of the wide nasal tip is challenging. Achieving an attractive, slender, and functional tip complex without destabilizing the lower nasal sidewall or deforming the contracture-prone alar rim is a formidable task. Excisional refinement techniques that rely upon incremental weakening of wide lower lateral cartilages (LLC) often destabilize the tip complex and distort tip contour. Initial destabilization of the LLC is usually further exacerbated by "shrink-wrap" contracture, which often leads to progressive cephalic retraction of the alar margin. The result is a misshapen tip complex accentuated by a conspicuous and highly objectionable nostril deformity that is often very difficult to treat. The "articulated" alar rim graft (AARG) is a modification of the conventional rim graft that improves treatment of secondary alar rim deformities, including postsurgical alar retraction (PSAR). Unlike the conventional alar rim graft, the AARG is sutured to the underlying tip complex to provide direct stationary support to the alar margin, thereby enhancing graft efficacy. When used in conjunction with a well-designed septal extension graft (SEG) to stabilize the central tip complex, lateral crural tensioning (LCT) to tighten the lower nasal sidewalls and minimize soft-tissue laxity, and lysis of scar adhesions to unfurl the retracted and scarred nasal lining, the AARG can eliminate PSAR in a majority of patients. The AARG is also highly effective for prophylaxis against alar retraction and in the treatment of most other contour abnormalities involving the alar margin. Moreover, the AARG requires comparatively little graft material, and complications are rare. We present a retrospective series of 47 consecutive patients treated with the triad of AARG, SEG, and LCT for prophylaxis and/or treatment of alar rim deformities. Outcomes were favorable in nearly all patients, and no complications were observed. We conclude the AARG is a simple and effective method for

  7. The Inner Rim in Protoplanetary Disks

    Science.gov (United States)

    Flock, Mario; Turner, Neal J.

    2016-10-01

    Many stars host planets orbiting within one astronomical unit (AU). These close planets origins are a mystery that motivates investigating protoplanetary disks central regions.A key factor governing the conditions near the star is the silicate sublimation front, which largely determines where the starlight is absorbed, and which is often called the inner rim. We present the first radiation hydrodynamical modeling of the sublimation front in the disks around the young intermediate-mass stars called Herbig Ae stars. The models are axisymmetric, and include starlight heating, silicate grains sublimating and condensing to equilibrium at the local, timedependent temperature and density, and accretion stresses parametrizing the results of MHD magneto-rotational turbulence models.The results show for the first time the dynamical stability of the rim. Passing the model disks into Monte Carlo radiative transfer calculations allows us to directly compare with observational constraints. The inner rim has a substantial radial extent, corresponding to several disk scale heights. A pressure maximum develops at the position of thermal ionization at temperatures about 1000 K. The pressure maximum is capable of halting solid pebbles radial drift and concentrating them in a zone where temperatures are sufficiently high for annealing to form crystalline silicates.

  8. Unusual Bilateral Rim Fracture in Femoroacetabular Impingement

    Directory of Open Access Journals (Sweden)

    Claudio Rafols

    2015-01-01

    Full Text Available This is a report of one case of bilateral acetabular rim fracture in association with femoroacetabular impingement (FAI, which was treated with a hip arthroscopic procedure, performing a partial resection, a labral reinsertion, and a subsequential internal fixation with cannulated screws. Up to date, there are in the literature only two reports of rim fracture and “os acetabuli” in association with FAI. In the case we present, the pincer and cam resection were performed without complications; the technique used was published previously. With this technique the head of the screw lays hidden by the reattached labrum. We removed partially the fractured rim fragment and the internal fixation of the remaining portion was achieved with a screw. In the event of a complete resection of the fragment, it would have ended with a LCE angle of 18° and a high probability of hip instability. We believe that this bilateral case helps establish the efficacy and reproducibility of the technique described by Larson.

  9. Effects of altered catecholamine metabolism on pigmentation and physical properties of sclerotized regions in the silkworm melanism mutant.

    Directory of Open Access Journals (Sweden)

    Liang Qiao

    Full Text Available Catecholamine metabolism plays an important role in the determination of insect body color and cuticle sclerotization. To date, limited research has focused on these processes in silkworm. In the current study, we analyzed the interactions between catecholamines and melanin genes and their effects on the pigmentation patterns and physical properties of sclerotized regions in silkworm, using the melanic mutant melanism (mln silkworm strain as a model. Injection of β-alanine into mln mutant silkworm induced a change in catecholamine metabolism and turned its body color yellow. Further investigation of the catecholamine content and expression levels of the corresponding melanin genes from different developmental stages of Dazao-mln (mutant and Dazao (wild-type silkworm revealed that at the larval and adult stages, the expression patterns of melanin genes precipitated dopamine accumulation corresponding to functional loss of Bm-iAANAT, a repressive effect of excess NBAD on ebony, and upregulation of tan in the Dazao-mln strain. During the early pupal stage, dopamine did not accumulate in Dazao-mln, since upregulation of ebony and black genes led to conversion of high amounts of dopamine into NBAD, resulting in deep yellow cuticles. Scanning electron microscope analysis of a cross-section of adult dorsal plates from both wild-type and mutant silkworm disclosed the formation of different layers in Dazao-mln owing to lack of NADA, compared to even and dense layers in Dazao. Analysis of the mechanical properties of the anterior wings revealed higher storage modulus and lower loss tangent in Dazao-mln, which was closely associated with the altered catecholamine metabolism in the mutant strain. Based on these findings, we conclude that catecholamine metabolism is crucial for the color pattern and physical properties of cuticles in silkworm. Our results should provide a significant contribution to Lepidoptera cuticle tanning research.

  10. [Unilateral visual field defect due to optic nerve compression by sclerotic internal carotid artery: a case report].

    Science.gov (United States)

    Uchino, M; Nemoto, M; Ohtsuka, T; Kuramitsu, T; Isobe, Y

    1999-02-01

    A case of unilateral visual field defect due to optic nerve compression by a sclerotic internal carotid artery was reported. A 71-year-old woman was admitted to our department because of constricted visual field of the right eye. MRI showed elevation of the right optic nerve compressed by an internal carotid artery. The right carotid angiography revealed elevation and distortion of the C1-2 portion. Frontal craniotomy was carried out and the optic nerve was visualized on this side. The right optic nerve was found to have been compressed by the sclerotic internal carotid artery. The optic canal was then unroofed. The post-operative course was uneventful. The visual field was improved. When last seen 6 months after surgery, her visual field remained in the improved condition. Nasal field abnormalities are most frequently encountered in retinal and anterior optic nerve pathology. Our success in improving the visual field disturbance may be accounted for by the fact that the preoperative period was short and the operation was performed before atrophy of ocular fundi occurred. Nasal field loss caused by intracranial lesions of the optic pathway is rare. It is probably impossible to determine degree of the symptomatology caused by direct-pressure compression as opposed to that caused by ischemia secondary to occlusion of small arterial supply branches. Vascular compressive neuropathy of optic nerve should not be diagnosed simply by the radiological finding of the optic nerve dislocation. However, optic nerve compression by surrounding arteries should be remembered as one of the possible causes of visual field defect which needs to be treated surgically. PMID:10065453

  11. Oculopharyngeal Weakness, Hypophrenia, Deafness, and Impaired Vision: A Novel Autosomal Dominant Myopathy with Rimmed Vacuoles

    Science.gov (United States)

    Chen, Ting; Lu, Xiang-Hui; Wang, Hui-Fang; Ban, Rui; Liu, Hua-Xu; Shi, Qiang; Wang, Qian; Yin, Xi; Pu, Chuan-Qiang

    2016-01-01

    Background: Myopathies with rimmed vacuoles are a heterogeneous group of muscle disorders with progressive muscle weakness and varied clinical manifestations but similar features in muscle biopsies. Here, we describe a novel autosomal dominant myopathy with rimmed vacuoles in a large family with 11 patients of three generations affected. Methods: A clinical study including family history, obstetric, pediatric, and development history was recorded. Clinical examinations including physical examination, electromyography (EMG), serum creatine kinase (CK), bone X-rays, and brain magnetic resonance imaging (MRI) were performed in this family. Open muscle biopsies were performed on the proband and his mother. To find the causative gene, the whole-exome sequencing was carried out. Results: Disease onset was from adolescence to adulthood, but the affected patients of the third generation presented an earlier onset and more severe clinical manifestations than the older generations. Clinical features were characterized as dysarthria, dysphagia, external ophthalmoplegia, limb weakness, hypophrenia, deafness, and impaired vision. However, not every patient manifested all symptoms. Serum CK was mildly elevated and EMG indicated a myopathic pattern. Brain MRI showed cerebellum and brain stem mildly atrophy. Rimmed vacuoles and inclusion bodies were observed in muscle biopsy. The whole-exome sequencing was performed, but the causative gene has not been found. Conclusions: We reported a novel autosomal dominant myopathy with rimmed vacuoles characterized by dysarthria, dysphagia, external ophthalmoplegia, limb weakness, hypophrenia, deafness, and impaired vision, but the causative gene has not been found and needs further study. PMID:27453229

  12. Dual-time-point FDG-PET/CT Imaging of Temporal Bone Chondroblastoma: A Report of Two Cases

    OpenAIRE

    Akira Toriihara; Atsunobu Tsunoda; Akira Takemoto; Kazunori Kubota; Youichi Machida; Ukihide Tateishi

    2015-01-01

    Temporal bone chondroblastoma is an extremely rare benign bone tumor. We encountered two cases showing similar imaging findings on computed tomography (CT), magnetic resonance imaging (MRI), and dual-time-point 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/CT. In both cases, CT images revealed temporal bone defects and sclerotic changes around the tumor. Most parts of the tumor showed low signal intensity on T2- weighted MRI images and non-uniform enhancement on gadolini...

  13. Hypercalcemia and altered biochemical bone markers in post-bone marrow transplantation osteopetrosis: a case report and literature review.

    Science.gov (United States)

    Kulpiya, Alisa; Mahachoklertwattana, Pat; Pakakasama, Samart; Hongeng, Suradej; Poomthavorn, Preamrudee

    2012-08-01

    Autosomal recessive osteopetrosis is a rare disorder of bone resorption defect that results in generalized sclerotic bones and bone marrow failure. Allogeneic BMT is the only treatment for cure. One of the complications following a successful BMT is hypercalcemia that is a unique complication in this group of patients. We report a three-yr-old boy with osteopetrosis who developed hypercalcemia following the successful BMT. His maximal calcium level was 13.3 mg/dL. Markedly increased both bone formation and resorption markers were demonstrated along with hypercalcemia. These findings indicated an active donor-derived osteoclastic function and thus bone resorption following the successful donor engraftment in the patient. Treatment with hyperhydration, furosemide and bone resorption inhibitors, calcitonin, and bisphosphonate led to normalization of the serum calcium level. Bone resorption but not bone formation marker was persistently elevated despite having normocalcemia during a 16.5-month follow-up period. PMID:21323826

  14. 4th Pacific Rim Underwater Acoustics Conference

    CERN Document Server

    Xu, Wen; Cheng, Qianliu; Zhao, Hangfang

    2016-01-01

    These proceedings are a collection of 16 selected scientific papers and reviews by distinguished international experts that were presented at the 4th Pacific Rim Underwater Acoustics Conference (PRUAC), held in Hangzhou, China in October 2013. The topics discussed at the conference include internal wave observation and prediction; environmental uncertainty and coupling to sound propagation; environmental noise and ocean dynamics; dynamic modeling in acoustic fields; acoustic tomography and ocean parameter estimation; time reversal and matched field processing; underwater acoustic localization and communication as well as measurement instrumentations and platforms. These proceedings provide insights into the latest developments in underwater acoustics, promoting the exchange of ideas for the benefit of future research.

  15. Bleomycin-induced epithelial–mesenchymal transition in sclerotic skin of mice: Possible role of oxidative stress in the pathogenesis

    International Nuclear Information System (INIS)

    Epithelial–mesenchymal transition (EMT) derived myofibroblasts are partly responsible for the increased collagen synthesis and deposition that occur in tissue fibrosis; however EMT occurrence in skin fibrosis and its mechanism remain unknown. The aim of this study was to investigate whether epithelial cells undergo EMT and determine the role of oxidative stress in this process. BALB/c mice were subcutaneously injected with bleomycin (BLM) or phosphate buffer saline (PBS) into the shaved back daily for 2, 3, and 4 weeks. Skin collagen deposition was evaluated by histopathology and Western blotting. EMT characteristics in the skin were determined by histopathology and immunofluorescent staining for E-cadherin and vimentin, which were further evaluated by Western blotting and reverse transcriptase polymerase chain reaction (RT-PCR). To investigate the role of oxidative stress in EMT, the antioxidant N-acetylcysteine (NAC) was intraperitoneally (100 mg/kg body weight/day) injected daily for 3 weeks. The epithelial suprabasal cells were detached from the basement membrane zone (BMZ) in the sclerotic skin treated with BLM. Immunofluorescent staining indicated vimentin-positive epithelial cells frequently occurring in the thickened epidermis of BLM-treated mice. Western blotting and RT-PCR showed that the expression of E-cadherin was significantly decreased but that of vimentin significantly increased in the skin treated with BLM. NAC attenuated BLM induced oxidative damage, changes in E-cadherin and vimentin expressions and collagen deposition in the sclerotic skin of mice. This study provides the first evidence that BLM induces the EMT of the epithelial cells superficial to the basement membrane zone in the skin fibrosis. Oxidative stress may contribute, at least in part, to BLM induced EMT and skin fibrosis in mice. - Highlights: • We provided the first evidence that EMT occurred in BLM-induced skin fibrosis. • Epithelial cells superficial to the BMZ underwent

  16. Bleomycin-induced epithelial–mesenchymal transition in sclerotic skin of mice: Possible role of oxidative stress in the pathogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Cheng-Fan, E-mail: zhouchengfan@sohu.com [Institute of Dermatology, the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230022 (China); Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032 (China); Zhou, Deng-Chuan [Department of Emergency Medicine and Critical Care Medicine, the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230022 (China); Zhang, Jia-Xiang; Wang, Feng; Cha, Wan-Sheng [Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032 (China); Wu, Chang-Hao [Department of Biochemistry and Physiology, Faculty of Health and Medical Sciences, University of Surrey (United Kingdom); Zhu, Qi-Xing, E-mail: zqxing@yeah.net [Institute of Dermatology, the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230022 (China); Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032 (China)

    2014-06-15

    Epithelial–mesenchymal transition (EMT) derived myofibroblasts are partly responsible for the increased collagen synthesis and deposition that occur in tissue fibrosis; however EMT occurrence in skin fibrosis and its mechanism remain unknown. The aim of this study was to investigate whether epithelial cells undergo EMT and determine the role of oxidative stress in this process. BALB/c mice were subcutaneously injected with bleomycin (BLM) or phosphate buffer saline (PBS) into the shaved back daily for 2, 3, and 4 weeks. Skin collagen deposition was evaluated by histopathology and Western blotting. EMT characteristics in the skin were determined by histopathology and immunofluorescent staining for E-cadherin and vimentin, which were further evaluated by Western blotting and reverse transcriptase polymerase chain reaction (RT-PCR). To investigate the role of oxidative stress in EMT, the antioxidant N-acetylcysteine (NAC) was intraperitoneally (100 mg/kg body weight/day) injected daily for 3 weeks. The epithelial suprabasal cells were detached from the basement membrane zone (BMZ) in the sclerotic skin treated with BLM. Immunofluorescent staining indicated vimentin-positive epithelial cells frequently occurring in the thickened epidermis of BLM-treated mice. Western blotting and RT-PCR showed that the expression of E-cadherin was significantly decreased but that of vimentin significantly increased in the skin treated with BLM. NAC attenuated BLM induced oxidative damage, changes in E-cadherin and vimentin expressions and collagen deposition in the sclerotic skin of mice. This study provides the first evidence that BLM induces the EMT of the epithelial cells superficial to the basement membrane zone in the skin fibrosis. Oxidative stress may contribute, at least in part, to BLM induced EMT and skin fibrosis in mice. - Highlights: • We provided the first evidence that EMT occurred in BLM-induced skin fibrosis. • Epithelial cells superficial to the BMZ underwent

  17. Analysis of a Carbon Fibre Rim : Student Formula

    OpenAIRE

    Uyttersprot, Bryan

    2015-01-01

    This master’s thesis is within the context of a formula race competition between universities. The main goal is to replace the modern rims of the TAMK Student Formula car by lighter and more efficient rims. To achieve this goal, important topics such as general rim design, tyre forces, tyre moments, strength of materials, fatigue and mechanical properties of carbon fibre were examined. Carbon fibre was applied because of its decent strength, weight and fatigue characteristics. Two possib...

  18. Linhas escleróticas metafisárias em crianças e adolescentes em uso de alendronato Sclerotic metaphyseal lines in children and adolescents treated with alendronate

    Directory of Open Access Journals (Sweden)

    Érika C.C. Silva

    2010-06-01

    Full Text Available INTRODUÇÃO: Os bisfosfonatos inibem a reabsorção óssea pela interferência na ação dos osteoclastos. Dentre os efeitos adversos, as linhas escleróticas em metáfise de ossos longos são descritas como principal alteração radiográfica na faixa etária pediátrica. OBJETIVO: Avaliar a frequência de alterações radiográficas causadas pelo alendronato utilizado em crianças e adolescentes com baixa densidade óssea ou calcinose. PACIENTES E MÉTODOS: Foi realizado um estudo do tipo coorte retrospectiva analisando-se prontuários de 21 pacientes que fizeram uso de alendronato semanal por no mínimo 10 meses. Os pacientes realizaram radiografias de ossos longos antes do início do alendronato e aproximadamente um ano após o seu uso. RESULTADOS: Onze pacientes (52,3% apresentaram linhas escleróticas em metáfise dos ossos longos. A localização mais frequente foi em tíbia (8/11 pacientes, seguida de fêmur (7/11, úmero (6/11, rádio (4/11, ulna (3/11 e fíbula (2/11. Nenhum paciente apresentou regress��o das alterações radiográficas durante o tempo de evolução (até 1,1 ano após a suspensão do alendronato. CONCLUSÃO: Se usado com critério, o alendronato é seguro e as alterações radiográficas não mostraram ter um significado mais importante.INTRODUCTION: Bisphosphonates inhibit bone resorption by interfering with the action of osteoclasts. Among the adverse effects, sclerotic lines observed in the metaphysis of long bones have been described as the main imaging finding in pediatric patients. OBJECTIVE: To evaluate the frequency of radiographic changes caused by alendronate in children and adolescents with low bone density or calcinosis. PATIENTS AND METHODS: We conducted a cross-sectional study with 21 patients who were treated with once-weekly alendronate for at least 10 months. Patients underwent x-rays of long bones before the start of alendronate and approximately one year after its use. RESULTS: Eleven patients

  19. Business Strategy Analysis of RIM in China's Smartphone Industry

    OpenAIRE

    Chen, Lei

    2011-01-01

    China, the biggest mobile phone market in the world, is crucial for the future of Research In Motion (RIM). While RIM entered China’s market in 2006, its market share is still very small in China. The launch of 3G amid the restructuring of China’s telecom industry proved crucial to the company’s development. RIM has partnered with all mobile operators in China to provide BlackBerry Enterprise Service and BlackBerry Internet Service to both business and individual users. It has gained a compet...

  20. Computational fluid dynamics simulation of a rim driven thruster

    OpenAIRE

    Dubas, Aleksander J.; Bressloff, N. W.; Fangohr, H.; Sharkh, S.M.

    2011-01-01

    An electric rim driven thruster is a relatively new marine propulsion device that uses a motor in its casing to drive a propeller by its rim and the fluid dynamics associated with their operation have not been fully investigated. There are many interacting flow features that make up the flow field of a rim driven thruster that pose a number of challenges when it comes to simulating the device using computational fluid dynamics. The purpose of this work is to develop a computational fluid dyna...

  1. Bone tumors with an associated pathologic fracture: Differentiation between benign and malignant status using radiologic findings

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Ji Hyun; Lee, In Sook; Song, You Seon [Pusan National University School of Medicine, Pusan National University Hospital, Busan (Korea, Republic of); Kim, Jeung Il [Dept. of Radiology, Yeungnam University College of Medicine, Yeungnam University Medical Center, Daegu (Korea, Republic of); Lee, Moon Sung [Dept. of Radiology, Keimyung University College of Medicine, Dongsan Medical Center, Daegu (Korea, Republic of); Lee, Young Hwan [Dept. of Radiology, Catholic University of Daegu College of Medicine, Daegu Catholic University Hospital, Daegu (Korea, Republic of); Song, Jong Woon [Dept. of Radiology, Inje University College of Medicine, Haeundae Paik Hospital, Busan (Korea, Republic of)

    2015-10-15

    To determine whether benign and malignant bone tumors with associated pathologic fractures can be differentiated using radiologic findings. Seventy-eight patients (47 men and 31 women, age range: 1-93 years) with a bone tumor and an associated pathologic fracture from 2004 to 2013 constituted the retrospective study cohort. The tumor size, margin, and enhancement patterns; the presence of sclerotic margin, the peritumoral bone marrow, soft tissue edema, extra-osseous soft tissue mass, intratumoral cystic/hemorrhagic/necrotic regions, mineralization/sclerotic regions, periosteal reaction and its appearance; and cortical change and its appearance were evaluated on all images. Differences between the imaging characteristics of malignant and benign pathologic fractures were compared using Pearson's chi-square test and the 2-sample t-test. There were 22 benign and 56 malignant bone tumors. Some factors were found to significantly differentiate between benign and malignant tumors; specifically, ill-defined tumor margin, the presence of sclerotic tumor margin and an extra-osseous soft tissue mass, the absence of cystic/necrotic/hemorrhagic portions in a mass, the homogeneous enhancement pattern, and the presence of a displaced fracture and of underlying cortical change were suggestive of malignant pathologic fractures. Some imaging findings were helpful for differentiating between benign and malignant pathologic fractures.

  2. Bone tumors with an associated pathologic fracture: Differentiation between benign and malignant status using radiologic findings

    International Nuclear Information System (INIS)

    To determine whether benign and malignant bone tumors with associated pathologic fractures can be differentiated using radiologic findings. Seventy-eight patients (47 men and 31 women, age range: 1-93 years) with a bone tumor and an associated pathologic fracture from 2004 to 2013 constituted the retrospective study cohort. The tumor size, margin, and enhancement patterns; the presence of sclerotic margin, the peritumoral bone marrow, soft tissue edema, extra-osseous soft tissue mass, intratumoral cystic/hemorrhagic/necrotic regions, mineralization/sclerotic regions, periosteal reaction and its appearance; and cortical change and its appearance were evaluated on all images. Differences between the imaging characteristics of malignant and benign pathologic fractures were compared using Pearson's chi-square test and the 2-sample t-test. There were 22 benign and 56 malignant bone tumors. Some factors were found to significantly differentiate between benign and malignant tumors; specifically, ill-defined tumor margin, the presence of sclerotic tumor margin and an extra-osseous soft tissue mass, the absence of cystic/necrotic/hemorrhagic portions in a mass, the homogeneous enhancement pattern, and the presence of a displaced fracture and of underlying cortical change were suggestive of malignant pathologic fractures. Some imaging findings were helpful for differentiating between benign and malignant pathologic fractures

  3. Learning from California and the Pacific Rim

    International Nuclear Information System (INIS)

    Heavy oils are found in 10 of the 14 largest oilfields in Alaska and California. In the US west coast region, petroleum demand is dominated by light transport fuels, and there is a lack of a discrete and conspicuous heavy oil market. The structure and behavior of west coast petroleum markets, and their interactions with crude-oil and petroleum product markets elsewhere on the Pacific Rim are discussed with regard to how the market for growing volumes of western Canadian heavy oils might evolve. An analysis of crude oil prices versus API gravity demonstrates the price penalties on oil of low gravity, high sulfur, and high transport cost. Prices at the high gravity end tend to correlate closely with Asian light crude and unfinished gasoline prices. The heaviest crudes are priced in competition with other chemically similar residual oils for direct fuel use, blending, or refinery feedstock. The biggest component of the west coast heavy oil market is bunker fuel. The market value of heavy crudes in the west coast is thus determined by regional supply and demand for heavy hydrocarbon molecules, whatever the source. The west coast is not a promising market for Canadian heavy crudes, and exports to Asia would have to compete both with residual oils from Asia and the US west coast and with California heavy crudes. US west coast production peaked in 1989 and regional production can be expected to decline further in average gravity. New production from known but undeveloped heavy oil pools near Prudhoe Bay or in the California offshore could be expected to postpone the need for imports to the west coast and to depress prices. A removal of the Alaska crude oil export ban could improve the west coast heavy oil market. 5 refs., 2 figs., 1 tab

  4. Low volume fraction rimming flow in a rotating horizontal cylinder

    Science.gov (United States)

    Chen, Po-Ju; Tsai, Yu-Te; Liu, Ta-Jo; Wu, Ping-Yao

    2007-12-01

    An experimental study was carried out to examine how uniform rimming flow is established for a very small volume fraction of aqueous Newtonian solutions in a partially filled rotating horizontal cylinder. There exists a certain critical volume fraction (Vc) for each solution, where the rotational speed required to achieve uniform rimming flow takes a minimum value. Counterintuitively, it takes greater rotation speeds for both larger and smaller volume fractions than this. Axial instabilities are observed for liquid volume fractions above or below this critical value. For V >Vc the defects are mainly of shark-teeth and turbulent types, while for V speed for V >Vc, but has very little effect for V speed Ω to achieve rimming flow is presented as a function of the dimensionless liquid volume fraction ϕ. The competing effects of fluid inertia and viscous force on rimming flow are demonstrated from a dimensionless plot of Ω versus ϕ.

  5. Rim instability in dewetting of thin polymer films

    OpenAIRE

    Marquant, Ludovic

    2013-01-01

    Understanding flow properties at the solid/liquid interface is important for numerous of technological applications in nanotechnology and microfluidic. The strong scientific interest in the field of thin liquid films led to new conclusions on the impact of hydrodynamic slippage on the dewetting dynamics and on the shape of the rim growing at the three phase contact line. This work consists of verifying the validity of these findings at late stage of dewetting, i.e. while the rim instabilit...

  6. A STUDY OF HAEMOGLOBIN PATTERNS AMONG THE STUDENTS OF RIMS

    OpenAIRE

    Urmila; Sunita,; Mohen Singh; Durlav Chandra

    2015-01-01

    Haemoglobinopathies are a major health problem worldwide. Because of the high prevalence of these disorders in India and especially in North–East, we undertook this limited student based study as RIMS comprised students from the seven North-East states of Arunachal Pradesh, Manipur, Meghalaya, Mizoram, Nagaland, Sikkim and Tripura. AIMS: To study the prevalence of haemoglobin variants among the North-East students of RIMS and to find out any abnormal haemoglobin pattern pertai...

  7. Hand rim configuration : effects on physical strain and technique in unimpaired subjects?

    NARCIS (Netherlands)

    van der Woude, L H V; Formanoy, M; de Groot, S

    2003-01-01

    OBJECTIVE: Hand rim wheelchair propulsion is inefficient and physically straining. To evaluate the possibly advantageous role in this respect of three different prototype hand rim configurations (a rubber foam-coated cylindrical (II) hand rim and two profiled rubber foam-coated hand rims (wide and n

  8. Implications of the β Lyrae accretion disk rim Teff

    Science.gov (United States)

    Linnell, A. P.

    2000-12-01

    Photometric evidence indicates that the massive gainer in the β Lyrae system is hidden from the observer by a thick accretion disk (Linnell, Hubeny, & Harmanec, 1998, ApJ, 509, 379). It is believed that the gainer approximates a main sequence star of Teff= 30000K. Spectroscopic analysis by Balachrandan et al. (1986, MNRAS, 219, 479) establishes a Teff of 13,300K for the donor. System synthetic spectra, fitted via the BINSYN suite to spectrophotometric scan data and IUE spectra, establish a mean rim Teff of 9000K. Assuming conservative mass transfer, Harmanec & Scholz (1993, A&A, 279, 131) use the rate of period change to derive a mass transfer rate of 20x10-6M⊙ yr-1. Connecting the rim Teff to the accretion disk face Teff with the Hubeny theory (Hubeny & Plavec 1991, AJ, 102, 1156) and using the standard accretion disk relations (Frank, King & Raine), the adopted mass transfer rate predicts a rim Teff of 4500K. The BINSYN-derived 9000K rim Teff would require a mass transfer rate 30 times larger than the adopted value. The observed rate of period change excludes such a large mass transfer rate. The bolometric luminosity of the rim, from the BINSYN model, is 5.6x1036erg sec-1. The bolometric luminosity of the gainer, on the adopted model, is 9.8x1037erg sec-1. Thus, the luminosity of the rim is 6% of the luminosity of the gainer. On the BINSYN model, the accretion disk covers 26% of the sky, as seen by the gainer. Absorption of radiation from the gainer, and its reradiation by the accretion disk, could explain the derived Teff of the rim. The conclusion is that the β Lyrae accretion disk structure must be strongly affected by radiation from the hot gainer (unseen by the observer) at the center of the accretion disk.

  9. Intraosseous lipoma of the iliac: case report☆

    Science.gov (United States)

    de Moraes, Frederico Barra; Paranahyba, Rodrigo Marques; do Amaral, Rogério Andrade; Bonfim, Vinícius Mendes; Jordão, Nathalya Ducarmo; Souza, Raimundo Djalma

    2016-01-01

    Lipomas are benign tumors that attack fat cells and most often affecting soft tissues in adulthood. On rare occasions, they may affect bones, preferentially the metaphyses of the long bone. They are generally asymptomatic and radiography shows radiolucent lesions with a thin sclerotic rim or radiodense lesions with a thick sclerotic rim. Malignant transformation of these tumors is rare, as is their recurrence, and there is no need for surgery in most cases. In this report, we present a rare case of intraosseous lipoma in the iliac bone. PMID:26962507

  10. Regional carrying capacity: case studies of Bohai Rim area

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Carrying capacity research has been carried out for a long time. However, synthesized carrying capacity researches based on systematic views began only in the 1970s. There is even less work done in China. This paper tries to address both synthesized carrying capacity research and its utilization in China. State spaces method from the systematic science was borrowed to construct the conceptual model of regional carrying capacity. Based on the conceptual model and the surveys in the Bohai Rim area, we construct a representative indicators system for quantifying regional carrying capacity in the Bohai Rim. While employing system dynamic models we simulated the evolving trend of both the regional carrying states and regional carrying capacity from 1999 to 2015. The results proved the statement that Bohai Rim is overall over-capacity for a long time and will be over-capacity in the foreseeable future. Among all the restriction factors, water shortage and environmental pollution stand out to be the two primary obstacles for Bohai Rim's sustainable development.Regional differentiation analysis further indicates that coastal areas of the Bohai Rim burden more than its overall level. However, Shandong province shows some good signs in addressing the regional carrying capacity issues. The research is successful in addressing the quantification of regional carrying capacity issues, but nonetheless it needs further refinery and more information.

  11. A simplified procedure for preparation of undecalcified human bone sections

    DEFF Research Database (Denmark)

    Wallin, J A; Tkocz, I; Levinsen, J

    1985-01-01

    A new type of apparatus for sectioning samples of hard, undecalcified bone is described. Slices of fresh or archeological human bone 4-5 mm thick are dehydrated and then embedded in epoxy resin. The apparatus used to prepare sections from the resulting blocks consists of a low-speed rim-type diam...

  12. Analytical capabilities of RIMS: absolute sensitivity and isotopic analysis

    International Nuclear Information System (INIS)

    Resonance ionization mass spectrometry (RIMS) with thermal filament sources is becoming an established analytical technique. The results of recent isotope ratio measurements carried out on small (60 - 200ng) lutetium samples are presented. The sensitivity and selectivity of continuous wave (CW) laser RIMS allow the accurate determination of very large ratios (approx. 106) in real samples containing numerous isobaric interferences. In addition, high resolution optical spectra of lutetium isotopes have been generated using RIMS as a prelude to isotopically selective resonance ionization. Also, the results of two-color spectroscopic studies for isotope ratio measurements in technetium are presented. A large number of multiply-resonant sequences have been explored; however, the presence of Tc molecular species appears to limit the potential sensitivity of the measurement. (author)

  13. Observations of neutral carbon in the NGC 1977 bright rim

    Science.gov (United States)

    Wootten, A.; Phillips, T. G.; Beichman, C. A.; Frerking, M.

    1982-01-01

    Strong neutral carbon emission at 610 microns (492 GHz) has been detected from a bright-rimmed cloud abutting the H II region NGC 1977. The similarity of velocity and width between (C-13)O and C I lines suggests that both lines originate in the same region. A model for the density and temperature structure of the cloud, based on (C-13)O and (C-12)O observations, has been used to estimate the carbon abundance. The abundances of both C I and (C-13)O increase with depth into the cloud away from the rim. The carbon abundance reaches its peak value nearer the rim than does the (C-13)O abundance. This variation in the relative abundance distributions of CO and C I confirms the importance of photodissociation in the chemistry of molecular clouds, and of the C I line to studies of the interaction of hot stars with clouds.

  14. Bone tumor

    Science.gov (United States)

    Tumor - bone; Bone cancer; Primary bone tumor; Secondary bone tumor ... The cause of bone tumors is unknown. They often occur in areas of the bone that grow rapidly. Possible causes include: Genetic defects ...

  15. Experimental study of THGEM detector with mini-rim

    CERN Document Server

    Zhang, Ai-Wu; Xie, Yu-Guang; Liu, Hong-Bang; An, Zheng-Hua; Wang, Zhi-Gang; Cai, Xiao; Sun, Xi-Lei; Shi, Feng; Fang, Jian; Xue, Zhen; Lu, Qi-Wen; Sun, Li-Jun; Ge, Yong-Shuai; Liu, Ying-Biao; Hu, Tao; Zhou, Li; Lu, Jun-Guang

    2011-01-01

    The gas gain and energy resolution of single and double THGEM detectors (5{\\times}5cm2 effective area) with mini-rims (rim is less than 10{\\mu}m) were studied. The maximum gain can reach 5{\\times}103 and 2{\\times}105 for single and double THGEM respectively, while the energy resolution of 5.9 keV X-ray varied from 18% to 28% for both single and double THGEM detectors of different hole sizes and thicknesses.All the experiments were investigated in mixture of noble gases(argon,neon) and small content of other gases(iso-butane,methane) at atmospheric pressure.

  16. Performance of Non-Cemented, Hemispherical, Rim-Fit, Hydroxyapatite Coated Acetabular Component.

    Science.gov (United States)

    John, Thomas K; Ghosh, Gaurav; Ranawat, Chitranjan S; Ranawat, Amar S; Meftah, Morteza

    2015-12-01

    The purpose of this study was to assess the durability of a non-cemented, hemispherical rim-fit, hydroxyapatite coated cup with a highly cross-linked polyethylene in 223 total hip arthroplasties. At 6-years follow-up (range, 5-9), there were no cup revisions for osteolysis or loosening. Radiologic evidence of osseointegration was based on presence of Stress Induced Reactive Cancellous Bone and radial trabeculae, seen in 47% and 93% of cups, respectively; both were most prevalent in Zone 1. There was no interference demarcation in any zones. Two cups were revised (0.9%): one for dislocation and another for infection. The Kaplan-Meier survivorship for cup revision for any failure (infection, dislocation) was 99% and for mechanical failure (osteolysis, loosening) was 100%. This design has excellent safety, efficacy and durability. PMID:26235521

  17. The imaging features of the chondroblastoma in the tarsal bone%足跗骨软骨母细胞瘤的影像学表现

    Institute of Scientific and Technical Information of China (English)

    彭俊红; 周利华; 黄利华; 王慧明; 阮学广

    2012-01-01

    目的:总结分析足跗骨软骨母细胞瘤的影像学表现.方法:回顾性分析经临床病理证实的发生于足跗骨的5例软骨母细胞瘤的X线、CT及MRI表现.结果:5例均单发,2例位于跟骨,2例位于距骨,1例位于舟骨.X线主要表现为圆形或卵圆形透亮影,边界清楚,5例均可见病灶边缘硬化带形成,病灶内未见明显钙化.CT扫描显示肿瘤呈膨胀性生长,骨质破坏区边界锐利、硬化,灶周软组织肿胀,未见骨膜反应及软组织肿块,增强扫描呈轻度不均匀强化.MRI可见病灶形态呈分叶状,呈长、稍长T1信号,混杂T2信号,伴有灶周骨髓水肿及关节腔积液,灶周软组织水肿,增强扫描亦呈轻度不均匀强化.结论:足跗骨软骨母细胞瘤较少见,其影像学表现具有一定特征性.%Objective:To analyze the imaging features of the chondroblastoma in the tarsal bone,and enhance the com petence of diagnosis. Methods:The X ray,CT and MRI imaging of 5 cases with pathology proved chondroblastoma which were located in the tarsal bone were retrospectively analyzed. Results:Of all the 5 cases,the locations of tumors were as fol forws:calcaneus(n=2),talus(n=2),navicular bone (n=1).The main radiographic manifestations were round or oval translucent area witn well delined margin, sclerotic rim,and no calcilications in all lesions. On CT scan,thee tumor demon strated expansive growth patterns,by showing well defined bone destruction with sclerosis rim. The adjacent soft tissue ede ma,without periosteal reaction and soft tissue masses were observed. The contrast enhancement was mild. Lesions demon strated heterogeneous MR signal intensity on T1WI and T2 WI. Lobular margins,adjacent bone marrow edema and joint ef fusion were found. The contrast enhancement was mild too. Conclusion: Characteristic imaging features could be revealed in the uncommon cnondroblastoma of the tarsal bone,which were helpful in the diagnosis.

  18. Asia and the Pacific Rim in the Curriculum.

    Science.gov (United States)

    Schlene, Vickie J.

    1991-01-01

    Presents a sampling of items from the ERIC database dealing with Asia and the Pacific Rim. Urges the inclusion of these countries in the curriculum as exchange of peoples, goods, and cultures increases. Emphasizes the growing importance of the region as a global force. Includes articles and books on culture, economies, and cultural exchange…

  19. Banjo Rim Height and Sound in the Pot

    CERN Document Server

    Politzer, David

    2016-01-01

    Rim and back geometry determine much of the behavior of sound inside the pot, whose effect on total, produced sound is subtle but discernible. The theory of sound inside a cylinder is reviewed and demonstrated. And previous work on the Helmholtz resonance and the interplay between the Helmholtz resonance and the lowest head mode is revisited using some improved techniques.

  20. Child-Centered Education for Pacific-Rim Cultures?

    Science.gov (United States)

    Jackson, Peter W.

    1998-01-01

    Argues for a cautious approach to transplanting theory from one culture to another, particularly considering the case for applying Friedrich Froebel's child-centered theory to early childhood education in Pacific Rim cultures. Uses a historical approach to distinguish three distinct versions of the theory, the Christian, the Progressive, and the…

  1. The Rim Trail at Pipe Spring National Monument, Arizona (pisp_trail)

    Data.gov (United States)

    National Park Service, Department of the Interior — This is an Arc/Info coverage consisting of 4 arcs representing The Rim Trail at Pipe Spring National Monument, Arizona. The Rim Trail was collected by a Trimble...

  2. Bone Biopsy

    Science.gov (United States)

    ... Physician Resources Professions Site Index A-Z Bone Biopsy Bone biopsy uses a needle and imaging guidance ... limitations of Bone Biopsy? What is a Bone Biopsy? A bone biopsy is an image-guided procedure ...

  3. Bone Diseases

    Science.gov (United States)

    ... avoid smoking and drinking too much alcohol. Bone diseases can make bones easy to break. Different kinds ... break Osteogenesis imperfecta makes your bones brittle Paget's disease of bone makes them weak Bones can also ...

  4. Experimental study of a THGEM detectorwith mini-rims

    Institute of Scientific and Technical Information of China (English)

    ZHANG Ai-Wu; FANG Jian; XUE Zhen; LU Qi-Wen; SUN Li-Jun; GE Yong-Shuai; LIU Ying-Biao; HU Tao; ZHOU Li; LU Jun-Guang; YU Bo-Xiang; XIE Yu-Guang; LIU Hong-Bang; AN Zheng-Hua; WANG Zhi-Gang; CAI Xiao; SUN Xi-Lei; SHI Feng

    2012-01-01

    The gas gain and energy resolution of single and double THGEM detectors (5 cm×5 cm effective area) with mini-rims (rim less than 10 μm) were studied.The maximum gain was found to reach 5× l03 and 2× 105 for single and double THGEMs respectively,while the energy resolution for 5.9 keV X-rays varied from 18% to 28% for both single and double THGEM detectors of different hole sizes and thicknesses.Different combinations were also investigated of noble gases (argon,neon) mixed with a quantity of other gases (isobutane,methane) at atmospheric pressure.

  5. Stability Analysis of Non-Newtonian Rimming Flow

    CERN Document Server

    Fomin, Sergei; Haine, Peter

    2015-01-01

    The rimming flow of a viscoelastic thin film inside a rotating horizontal cylinder is studied theoretically. Attention is given to the onset of non-Newtonian free-surface instability in creeping flow. This non-inertial instability has been observed in experiments, but current theoretical models of Newtonian fluids can neither describe its origin nor explain its onset. This study examines two models of non Newtonian fluids to see if the experimentally observed instability can be predicted analytically. The non-Newtonian viscosity and elastic properties of the fluid are described by the Generalized Newtonian Fluid (GNF) and Second Order Viscoelastic Fluid (SOVF) constitutive models, respectively. With linear stability analysis, it is found that, analogously to the Newtonian fluid, rimming flow of viscous non-Newtonian fluids (modeled by GNF) is neutrally stable. However, the viscoelastic properties of the fluid (modeled by SOVF) are found to contribute to the flow destabilization. The instability is shown to in...

  6. rimäärittely katsojakokemuksen vahvistajana elokuvassa

    OpenAIRE

    Köteleki, Sabina

    2015-01-01

    Kirjallisessa opinnäytetyössäni käsitellään elokuvien värien käyttöä ja värimäärittelyä katsojakokemuksen vahvistajana. Sen tarkoituksena on osoittaa, että tarkasti mietityllä ja luovasti toteutetulla värimäärittelyllä pystytään ratkaisevasti vaikuttamaan katsojan tulkintaan ja parantamaan sitä. Katsojan ei tarvitse olla värien symboliikkaan tai jälkituotantotekniikoihin perehtynyt ihminen ymmärtääkseen elokuvien värien narratiivista voimaa, sillä ihmiset reagoivat väreihin täysin vaistonvara...

  7. Load carrying capacity analysis of materials for aluminium rims

    OpenAIRE

    Fajdiga, Matija; Čižman, Jure

    2015-01-01

    In this contribution we present an experimental simulation of the fatique strength of clamped aluminium rims. This is supported by numerical modelling using the Finite Element Method (FEM), which was used for stress-strain analysis of a model representing a clamped detail during bendings. The design and analysis of the model are made simultaneously on an integrated computer controlled test rig for testing the fatique strength of clamped parts subjected to bending. The simulation is evaluated ...

  8. Donor corneoscleral rim contamination by gentamicin-resistant organisms

    OpenAIRE

    Gopinathan Usha; Agrawal Vinay; Sharma Savitri; Rao Gullapalli

    1994-01-01

    Gentamicin is the most widely used antibiotic in the decontamination of donor cornea for penetrating keratoplasty. However, the incidence of resistance to gentamicin is on the rise. Bacterial isolates from 178 donor corneal rims were studied for gentamicin sensitivity. The overall rate of gentamicin resistance was 63.4%. At 86.2% the Pseudomonas. species had the highest rate of resistance, followed by Streptococci at 84.6%. The high rate of gentamicin resistance encounter...

  9. Ultrasonic Resonance Spectroscopy of Composite Rims for Flywheel Rotors

    Science.gov (United States)

    Harmon, Laura M.; Baaklini, George Y.

    2002-01-01

    Flywheel energy storage devices comprising multilayered composite rotor systems are being studied extensively for utilization in the International Space Station. These composite material systems were investigated with a recently developed ultrasonic resonance spectroscopy technique. The ultrasonic system employs a continuous swept-sine waveform and performs a fast Fourier transform (FFT) on the frequency response spectrum. In addition, the system is capable of equalizing the amount of energy at each frequency. Equalization of the frequency spectrum, along with interpretation of the second FFT, aids in the evaluation of the fundamental frequency. The frequency responses from multilayered material samples, with and without known defects, were analyzed to assess the capabilities and limitations of this nondestructive evaluation technique for material characterization and defect detection. Amplitude and frequency changes were studied from ultrasonic responses of thick composite rings and a multiring composite rim. A composite ring varying in thickness was evaluated to investigate the full thickness resonance. The frequency response characteristics from naturally occurring voids in a composite ring were investigated. Ultrasonic responses were compared from regions with and without machined voids in a composite ring and a multiring composite rim. Finally, ultrasonic responses from the multiring composite rim were compared before and after proof spin testing to 63,000 rpm.

  10. A radiographic investigation of third carpal bone injury in 42 racing thoroughbreds

    International Nuclear Information System (INIS)

    A retrospective study of carpal radiographs from 42 racing thoroughbreds with carpal lameness was performed. Radiographs from 50 carpal examinations were available for review. The radiographic findings pertaining to the third carpal bone were described. Fractures and/or sclerosis occurred almost exclusively within the radial fossa. The occurrence of sclerosis without fracture in 20 of the 50 carpal examinations was higher than anticipated, occurring in both the right and left third carpal bone with equal frequency. The right third carpal bone was more frequently fractured and more severely affected than the left. The sclerotic changes seen in the radial fossa of the third carpal bone may be stress-induced, possibly preceding more serious changes in the joint such as cartilage damage or gross fracture. Earlier recognition of sclerosis of the third carpal bone may help prevent more serious changes from occurring

  11. Hydrogeology associated to faulting of the Chicxulub Impact Crater rim

    Science.gov (United States)

    Rebolledo-Vieyra, M.; Hernandez-Terrones, L.; Almazan-Becerril, A.; Valadez-Cruz, F.

    2011-12-01

    The only surface expression of the Chicxulub Impact Crater is a Ring of Cenotes (sinkholes) whose density varies from several cenotes per kilometer, to several kilometers between each cenote. This ring has a radius of approximately 90 km and it is centered at Chicxulub Puerto. It is not known today whether the Ring of Cenotes is the surface expression of the transient cavity as some authors have suggested, or whether it is the outer rim of the impact structure. The center of the ring is approximately coincident with the center of the Chicxulub Impact Crater. Reactivation of K/T rim faults had been associated to the formation of the ring of cenotes. However, none of these models project such faults to the Tertiary sedimentary sequence; therefore we can only infer that the cenotes are associated to these faults. Other hypotheses include "post impact subsidence induced by slumping and viscous relaxation in the rim" and "slumping in the rim of the buried crater, differential thickness in the rocks overlying the crater, or solution collapse within porous impact deposits", others suggest duration of subaerial exposure and weathering as a principal reason both for difference in permeability and cenote density inside and outside the Ring. This is consistent with the evolution of surface features reported. While sedimentation occurred in the basin outlined by the Ring, erosion and karst weathering were taking place outside the Ring. The karst features are associated with gravity gradients, which have been interpreted as corresponding to peripheral faults of the buried crater. We conducted geoelectric tomography perpendicular to the ring of cenotes, where we mapped the karstic features in the area and we interpret the high permeability in this area, to be associated to the faults generated by the differential compaction of the sedimentary sequence within the crater. This fault system generates a secondary porosity with high permeability that allows the circulation of water

  12. Electric pulse treatment of rim wheel metal after operation

    Directory of Open Access Journals (Sweden)

    L.I.Vakulenko

    2013-02-01

    Full Text Available Introduction. Load increase on the wheel pair ax requires the use of railway wheels with the advanced complex of properties. Except strength properties, the properties of metal resistance to defect nucleation on the wheel thread are of high importance. The above mentioned properties increase is possible by using different technological decisions: alloying and heat strengthening. Purpose. The purpose is an attempt to estimate the softening degree of the wheel thread metal using the electric pulse treatment. Methodology. Electric pulse treatment (ET was carried out on the special plant in the conditions of JSC DS (Nikolayev city. As the property of metal strength the Vickers hardness number is used. The microstructure research was carried out using the light microscope. The material for research is the carbon steel of the rim fragment of railway wheel №181732, withdrawn after operation, containing 0,55%С, 0,74%Mn, 0,33%Si, 0,009%P, 0,01%S, 0,06% Ni, 0,1%Cr, 0,08%Cu. Findings. Exposing the rim fragment to electric pulse treatment (ET, the qualitative changes of internal structure of the wheel rim metal corresponded to the experimentally observed geometrical dimensions change of the specimen, depending on the cycles number. As a result of the treatment the reduction of cold strained metal hardness is observed. It was found out 20 % softening on the wheel thread for the І rim area the, for the ІІ rim area the 8% softening and for the ІІІ 11% softening in relation to the initial state. Originality. As a result of electric pulse treatment, the change of the specimen geometrical dimensions is observed. Depending on the number of cycles it causes softening effect. It is proved that the observed softening value during ET is qualitatively connected with the cold strain level on the rail wheel thread. Practical value. As a result of metal cold work on the wheel thread its resistance to the defect nucleation is being reduced. The resulted data can

  13. Interesting bone scans - unusual findings

    Energy Technology Data Exchange (ETDEWEB)

    Dobson, M.; Wadhwa, S.S.; Mansberg, R.; Fernandes, V.B. [Wollongong Hospital, Wollongong, NSW (Australia)

    1997-12-01

    A 59-year-old female with carcinoma of the colon and known liver metastatic disease was referred for bone scan to evaluate for bone metastases. Although no bone metastases were found, there was abnormal uptake noted in the liver corresponding to a metastatic calcified lesion. The only other findings were of degenerative disease in the cervical spine, right shoulder and small joints of the hands. A 69-year-old male with carcinoma of the prostate and right side low back pain was referred for bone scan. No focal abnormalities to suggest metastatic disease were identified; findings within the cervical spine, lumber spine and knees were presumed secondary to degenerative disease. Intermittent pain persisted and the patient was referred for a repeat bone scan six months later. Previous scan findings of degenerative disease and no metastatic disease were confirmed; however, closer inspection revealed an enlarged right kidney with significant retention of tracer in the pelvicalyceal system suggesting possible obstruction. A Retrograde pyelogram was performed, and no obvious obstruction demonstrated. As bone scan findings were very suggestive of obstruction, a DTPA scan with lasix was performed showing a dilated right collecting system with no functional obstruction. Given the degree of dilation, it is possible that the patient experiences intermittent PUJ obstruction causing his symptoms. A 33-year-old male with insulin dependent diabetes mellitus and viral arthritis was referred for a bone scan. A three phase revealed increased uptake in the region of the knee and leR proximal tibia. Delayed whole body images revealed multiple focal areas of osteoblastic activity in the leR tibia. Abnormal uptake was also seen in the upper third of the leR femur. The remainder of the skeletal survey was normal. X-ray correlation of the leR tibia and femoral findings was undertaken. Combinating unilateral changes on bone scan and X-ray although very suggestive of sclerotic polyostotic

  14. Growth arrest line mimicking lymphoma involvement: The findings of {sup 99m}Tc-MDP bone SPECT/CT and serial bone scan in a child with non-Hodgkin's lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Chan Woo; Kim, Ji Young; Choi, Yun Young; Lee, Seung Hun; Lee, Young Ho [Hanyang University Medical Center, Seoul (Korea, Republic of)

    2016-06-15

    Growth arrest lines appear as dense sclerotic lines parallel to the growth plate of long bones on radiography. We describe the case of a 9-year-old female with growth arrest lines initially masquerading as lymphoma involvement on {sup 99m}Tc-MDP bone scintigraphy who had been treated with chemotherapy for non-Hodgkin's lymphoma about 3 years previously. Subsequent regional bone SPECT/CT clearly diagnosed the growth arrest lines, and retrograde review of previous bone scintigraphy demonstrated line migration in this patient. Growth arrest lines should be considered a possible diagnosis on bone scintigraphy, especially in the surveillance of children who have experienced severe childhood infections, malnutrition, immobilization, or treatment with immunosuppressive or chemotherapeutic drugs that may inhibit bone growth.

  15. CT imaging of bone and bone marrow infiltration in malignant melanoma--Challenges and limitations for clinical staging in comparison to 18FDG-PET/CT.

    Science.gov (United States)

    Bier, Georg; Hoffmann, Vera; Kloth, Christopher; Othman, Ahmed E; Eigentler, Thomas; Garbe, Claus; La Fougère, Christian; Pfannenberg, Christina; Nikolaou, Konstantin; Klumpp, Bernhard

    2016-04-01

    Rationale of this study was the evaluation of the diagnostic value of computed tomography (CT) in the detection of bone marrow infiltration in comparison to PET/CT. Fifty patients (age 61 ± 15.12 years) with metastatic malignant melanoma underwent 18F-FDG-PET/CT, including contrast-enhanced CT. 2 readers evaluated the CT images in consensus for bone and bone marrow lesions focusing on lesion location, type and size. PET/CT was used as reference standard to estimate sensitivity, specificity, negative and positive predictive value. Moreover, the bone marrow density was estimated in the long bones and the sacral bone. Serum hamoglobin, thrombocyte level and S100 protein were correlated with the presence or absence of bone and bone marrow lesions. According to PET/CT as standard of reference, of 594 bone and medullary lesions 495 were considered malignant. Of these 77.8% were medullary, 20.4% lytic, 1% sclerotic and 0.8% mixed lytic/sclerotic. Contrast-enhanced CT yielded a lesion-based sensitivity of 36.8% and a specificity of 87.9% (PPV 93.8%; NPV 21.8%). Patient-based sensitivity and specificity were 78.8% and 82.4%, respectively. Of the missed lesions, most were medullary (95.8%). A disseminated bone marrow involvement (defined as >10 bone marrow lesions or diffuse infiltration of a whole body segment) was described in 11 cases, in 6 cases the disseminated involvement was underestimated or missed on CT. In cases with disseminated bone marrow involvement the bone marrow density was significantly higher in the humerus (p=0.04), but not in the femur or sacral bone (p=0.06). Multivariate analysis revealed no isolated effect of bone metastases on S100 serum and hemoglobin level, but both were significantly altered in patients with disseminated bone marrow involvement (p<0.05). In conclusion, the diagnostic value of computed tomography for the detection of bone marrow metastases in patients with melanoma, is limited. Especially in cases with disseminated bone marrow

  16. Rimmed vacuoles in Becker muscular dystrophy have similar features with inclusion myopathies.

    Directory of Open Access Journals (Sweden)

    Kazunari Momma

    Full Text Available Rimmed vacuoles in myofibers are thought to be due to the accumulation of autophagic vacuoles, and can be characteristic in certain myopathies with protein inclusions in myofibers. In this study, we performed a detailed clinical, molecular, and pathological characterization of Becker muscular dystrophy patients who have rimmed vacuoles in muscles. Among 65 Becker muscular dystrophy patients, we identified 12 patients who have rimmed vacuoles and 11 patients who have deletions in exons 45-48 in DMD gene. All patients having rimmed vacuoles showed milder clinical features compared to those without rimmed vacuoles. Interestingly, the rimmed vacuoles in Becker muscular dystrophy muscles seem to represent autophagic vacuoles and are also associated with polyubiquitinated protein aggregates. These findings support the notion that rimmed vacuoles can appear in Becker muscular dystrophy, and may be related to the chronic changes in muscle pathology induced by certain mutations in the DMD gene.

  17. Rimmed vacuoles in Becker muscular dystrophy have similar features with inclusion myopathies.

    Science.gov (United States)

    Momma, Kazunari; Noguchi, Satoru; Malicdan, May Christine V; Hayashi, Yukiko K; Minami, Narihiro; Kamakura, Keiko; Nonaka, Ikuya; Nishino, Ichizo

    2012-01-01

    Rimmed vacuoles in myofibers are thought to be due to the accumulation of autophagic vacuoles, and can be characteristic in certain myopathies with protein inclusions in myofibers. In this study, we performed a detailed clinical, molecular, and pathological characterization of Becker muscular dystrophy patients who have rimmed vacuoles in muscles. Among 65 Becker muscular dystrophy patients, we identified 12 patients who have rimmed vacuoles and 11 patients who have deletions in exons 45-48 in DMD gene. All patients having rimmed vacuoles showed milder clinical features compared to those without rimmed vacuoles. Interestingly, the rimmed vacuoles in Becker muscular dystrophy muscles seem to represent autophagic vacuoles and are also associated with polyubiquitinated protein aggregates. These findings support the notion that rimmed vacuoles can appear in Becker muscular dystrophy, and may be related to the chronic changes in muscle pathology induced by certain mutations in the DMD gene.

  18. Bone Grafts

    Science.gov (United States)

    ... repair and rebuild diseased bones in your hips, knees, spine, and sometimes other bones and joints. Grafts can also repair bone loss caused by some types of fractures or cancers. Once your body accepts the bone ...

  19. Growth kinetics of forsterite reaction rims at high-pressure

    Science.gov (United States)

    Nishihara, Yu; Maruyama, Genta; Nishi, Masayuki

    2016-08-01

    Growth kinetics of forsterite (Fo) reaction rims between periclase (Per) and enstatite (En) were studied experimentally at pressure (P) and temperature (T) conditions of 3.0-11.1 GPa and 1473-1873 K, respectively. Pt markers originally placed at the Per-En interface were always observed at the Per-Fo interface, which indicates that Mg and O are the diffusing species in Fo rim growth (Mg-O coupled diffusion). The presence of some En inclusions in Fo grains and the growth rate of the Fo rim suggests that grain boundary diffusion is dominant rather than lattice diffusion. Considering the very fast grain boundary diffusion of O in olivine, the Mg-O coupled grain boundary diffusion in Fo is deduced to be rate-limited by the diffusivity of Mg. Based on an analysis of data collected under dry conditions, the product of the Mg grain boundary diffusion coefficient (Dgb) and the effective grain boundary width (δ) was determined to be δDgb = δDgb,0exp[-(E∗ + PV∗)/RT] with δDgb,0 = 10-9.68 ± 1.51 m3/s, E∗ = 379 ± 44 kJ/mol and V∗ = -1.9 ± 1.4 cm3/mol. Our results, combined with previously reported data on Mg lattice diffusion in Fo, suggest that for Mg, the significance of grain boundary diffusion increases with depth in the Earth's upper mantle, although lattice diffusion is still dominant for typical mantle grain sizes of 1-10 mm.

  20. Bone within a bone

    Energy Technology Data Exchange (ETDEWEB)

    Williams, H.J.; Davies, A.M. E-mail: wendy.turner@roh.nhs.uk; Chapman, S

    2004-02-01

    The 'bone within a bone' appearance is a well-recognized radiological term with a variety of causes. It is important to recognize this appearance and also to be aware of the differential diagnosis. A number of common conditions infrequently cause this appearance. Other causes are rare and some remain primarily of historical interest, as they are no longer encountered in clinical practice. In this review we illustrate some of the conditions that can give the bone within a bone appearance and discuss the physiological and pathological aetiology of each where known.

  1. A STUDY OF HAEMOGLOBIN PATTERNS AMONG THE STUDENTS OF RIMS

    Directory of Open Access Journals (Sweden)

    Urmila

    2015-11-01

    Full Text Available Haemoglobinopathies are a major health problem worldwide. Because of the high prevalence of these disorders in India and especially in North–East, we undertook this limited student based study as RIMS comprised students from the seven North-East states of Arunachal Pradesh, Manipur, Meghalaya, Mizoram, Nagaland, Sikkim and Tripura. AIMS: To study the prevalence of haemoglobin variants among the North-East students of RIMS and to find out any abnormal haemoglobin pattern pertaining to a particular community. MATERIAL AND METHODS: The present study was carried out in the Department of Pathology, RIMS. From Sept. 2002 to Dec. 2004, our study included 100 student volunteers taking a minimum of ten from each of the seven states. History of presenting complaints, personal, family and past illness were taken. Physical examination was done with special emphasis on appearance, presence of pallor, jaundice and hepatosplenomegaly etc. Blood samples were collected in 2 EDTA vials, one was used for CBC and another for preparation of hemolysate. CBC was done for all cases by electronic cell counter supported by manual hemocytometry, peripheral blood examination and reticulocyte count. All the cases were routinely screened for haemoglobin type using standard alkaline cellulose acetate electrophoresis with Tris-Ethylene Diamine Tetra Acetic Acid (EDTA borate buffer. Fetal Hb. estimation, sickling test, serum bilirubin estimation were also done in relevant cases. RESULTS: Out of the 100 student volunteers studied, 98 cases showed HbA pattern in 46 males and 52 females while HbE was seen in 2 cases, 1 male and a female. The prevalence of HbE was 2% in our study, which belonged to the ethnic group of Garo of Meghalaya. Both case had mild anemia with microcytosis and normal reticulocyte count. Peripheral smear showed anisopoikilocytosis and target cells. RBC count, MCH values were within normal range. CONCLUSION: Our study showed that HbA was the predominant

  2. Investigation about crack propagation paths in thin rim gears

    Directory of Open Access Journals (Sweden)

    F. Curà

    2014-10-01

    Full Text Available Crack propagation in gears is a problem related not only to the life of the components, but also to the concept of failsafe design. Fail safe design means to design a component in order that, if a failure occurs, this may cause a “safe failure”. This aspect is very important above all in aerospace industry. As a matter of fact, in aerospace application, the need of reducing weight brings to produce gears with very thick rim and web. Considering thin rim gears, when a crack is nucleated near the tooth root, it may propagate through the tooth (causing the loss of the entire tooth or a portion of it or the propagation may follow a path across the wheel diameter (causing the projection of big parts of the gear that may break the gearbox and may cause serious damage to the aircraft. The first failure mode is define as “failsafe failure” and the second one as “catastrophic failure” and of course has to be avoided. Designers need to have robust design criteria in order to predict crack propagation paths and to avoid catastrophic failures. In literature, few works are present concerning this topic, in particular related to the effect of geometrical parameters that may affect the crack propagation. In this work a numerical analysis about crack propagation in gears with respect to the backup ratio (ratio between tooth height and rim thickness, initial crack position and shape has been done by means of the Extended FEM (XFEM technique, realizing 3D models. XFEM 3D is a relatively new technique consisting in enriching traditional finite elements with more complex shape functions; in this way it is possible to propagate crack also between mesh nodes and to have mesh independent results. Aim of this paper is to highlight the crack propagation path in order to give to designers an high confident design criterion, related to the gear geometry. In particular, the effect of both rim thickness and orientation of the initial crack have been considered

  3. Energy Dependence of Synchrotron X-Ray Rims in Tycho's Supernova Remnant

    CERN Document Server

    Tran, Aaron; Petre, Robert; Ressler, Sean M; Reynolds, Stephen P

    2015-01-01

    Several young supernova remnants exhibit thin X-ray bright rims of synchrotron radiation at their forward shocks. Thin rims require strong magnetic field amplification beyond simple shock compression if rim widths are only limited by electron energy losses. But, magnetic field damping behind the shock could produce similarly thin rims with less extreme field amplification. Variation of rim width with energy may thus discriminate between competing influences on rim widths. We measured rim widths around Tycho's supernova remnant in 5 energy bands using an archival 750 ks Chandra observation. Rims narrow with increasing energy and are well described by either loss-limited or damped scenarios, so X-ray rim width-energy dependence does not uniquely specify a model. But, radio counterparts to thin rims are not loss-limited and better reflect magnetic field structure. Joint radio and X-ray modeling favors magnetic damping in Tycho's SNR with damping lengths ~1--5% of remnant radius and magnetic field strengths ~50--...

  4. Dam and spillway construction to remediate a failed reservoir rim

    Energy Technology Data Exchange (ETDEWEB)

    Kostaschuk, R.; Grover, P.; Wanner, C. [AMEC Earth and Environmental Ltd., Calgary, AB (Canada); Lockhart, S. [Priddis Greens Golf and Country Club, Priddis, AB (Canada)

    2009-07-01

    Priddis Greens Golf and Country Club (PGGCC) is located in southern Alberta, about 25 kilometres southwest of Calgary. Lake Loon reservoir supplies water for irrigation of the 36-hole golf course and also supplies water to the water treatment plant that provides potable water to the golf course and the housing development. An earthen spillway channel on the reservoir rim failed by erosion at the PGGCC during an extreme flood event in June 2005. The failure resulted in loss of the reservoir for the water supply system servicing the golf course and its housing cooperative. Design and reconstruction of the reservoir rim were undertaken and a new concrete spillway structure was built. This paper provided background information on the June 2005 failure and provided an overview of the design concept for reservoir restoration. The Alberta Environment permitting process was also outlined. Hydrology, flood management and spillway design were explained in detail. A geotechnical design of earthworks was also provided. The paper concluded with a discussion of an emergency preparedness and response plan and operation, maintenance and surveillance manual that were developed for the project. 2 refs., 20 figs.

  5. Towards the mathematical model of rim structure formation

    Science.gov (United States)

    Kinoshita, M.

    1997-09-01

    The high burnup LWR UO 2 fuels show a notable micro-structural change around the pellet outer zone which is called the rim structure. It is observed at temperatures as low as 400°C so that fission track and cascade mixing could be the key mechanism. SEM observation revealed that the structure primarily appears on free surfaces of UO 2, indicating that strong sink for point defects may play a big role. And as generic observations, increase of lattice parameter indicates extensive amounts of vacancies are stored in high burnup fuel, which may induce the restructuring interacting with dislocations of high density at high burnup. Considering these observations a model of reaction-diffusion process of defects with irradiation induced transport is proposed. The equations are investigated numerically. The model indicates that an instability starts when the dislocation network starts intensive interaction with vacancy flux which is modified by interstitial diffusion between spatial segments. It appeared to be similar to the Turing type instability which indicates that the rim structure formation is one kind of the self-organizing processes of open reaction-diffusion systems.

  6. Optimization of Hydride Rim Formation in Unirradiated Zr 4 Cladding

    Energy Technology Data Exchange (ETDEWEB)

    Shimskey, Rick W.; Hanson, Brady D.; MacFarlan, Paul J.

    2013-09-30

    The purpose of this work is to build on the results reported in the M2 milestone M2FT 13PN0805051, document number FCRD-USED-2013-000151 (Hanson, 2013). In that work, it was demonstrated that unirradiated samples of zircaloy-4 cladding could be pre-hydrided at temperatures below 400°C in pure hydrogen gas and that the growth of hydrides on the surface could be controlled by changing the surface condition of the samples and form a desired hydride rim on the outside diameter of the cladding. The work performed at Pacific Northwest National Laboratory since the issuing of the M2 milestone has focused its efforts to optimize the formation of a hydride rim on available zircaloy-4 cladding samples by controlling temperature variation and gas flow control during pre-hydriding treatments. Surface conditioning of the outside surface was also examined as a variable. The results of test indicate that much of the variability in the hydride thickness is due to temperature variation occurring in the furnaces as well as how hydrogen gas flows across the sample surface. Efforts to examine other alloys, gas concentrations, and different surface conditioning plan to be pursed in the next FY as more cladding samples become available

  7. Non-destructive examination technique for steam turbine rotor disk rim cracking

    International Nuclear Information System (INIS)

    Turbine disk rim cracking in thermal and nuclear power plants has been a major reliability issue in recent years. This problem which includes both circumferential and radial direction cracking on the hidden face of rim fixation behind the blade hook has become very important in periodic non-destructive examination. To detect these defects, the UT inspection techniques using a conventional single angle probe and a phased array probe without removing blades from wheel rim are developed. This paper summarizes and discusses non-destructive examination methods for turbine rim cracking using phased array technique and other technique and these results. (author)

  8. Molecular markers for granulovacuolar degeneration are present in rimmed vacuoles.

    Directory of Open Access Journals (Sweden)

    Masahiro Nakamori

    Full Text Available BACKGROUND: Rimmed vacuoles (RVs are round-oval cytoplasmic inclusions, detected in muscle cells of patients with myopathies, such as inclusion body myositis (IBM and distal myopathy with RVs (DMRV. Granulovacuolar degeneration (GVD bodies are spherical vacuoles containing argentophilic and hematoxyphilic granules, and are one of the pathological hallmarks commonly found in hippocampal pyramidal neurons of patients with aging-related neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. These diseases are common in the elderly and share some pathological features. Therefore, we hypothesized that mechanisms of vacuolar formation in RVs and GVD bodies are common despite their role in two differing pathologies. We explored the components of RVs by immunohistochemistry, using antibodies for GVD markers. METHODS: Subjects included one AD case, eight cases of sporadic IBM, and three cases of DMRV. We compared immunoreactivity and staining patterns for GVD markers. These markers included: (1 tau-modifying proteins (caspase 3, cyclin-dependent kinase 5 [CDK5], casein kinase 1δ [CK1δ], and c-jun N-terminal kinase [JNK], (2 lipid raft-associated materials (annexin 2, leucine-rich repeat kinase 2 [LRRK2], and flotillin-1, and (3 other markers (charged multi-vesicular body protein 2B [CHMP2B] and phosphorylated transactive response DNA binding protein-43 [pTDP43] in both GVD bodies and RVs. Furthermore, we performed double staining of each GVD marker with pTDP43 to verify the co-localization. RESULTS: GVD markers, including lipid raft-associated proteins and tau kinases, were detected in RVs. CHMP2B, pTDP43, caspase 3, LRRK2, annexin 2 and flotillin-1 were detected on the rim and were diffusely distributed in the cytoplasm of RV-positive fibers. CDK5, CK1δ and JNK were detected only on the rim. In double staining experiments, all GVD markers colocalized with pTDP43 in RVs. CONCLUSIONS: These results suggest that RVs of muscle

  9. Grain-rimming kaolinite in Permian Rotliegend reservoir rocks

    Science.gov (United States)

    Waldmann, Svenja; Gaupp, Reinhard

    2016-04-01

    Upper Rotliegend sediments of Permian age from the northeast Netherlands show moderate to good reservoir qualities. The predominant control is by the presence of authigenic grain-rimming kaolinite, which has a negative, but in some parts also a positive, effect on reservoir quality. To better understand the formation and distribution of grain-rimming kaolinite, reservoir rocks were studied in terms of composition and diagenetic processes. Petrographic evidence, summarized as a paragenetic sequence, is integrated with geochemical modeling results to identify early mesodiagenetic water-rock interactions under the participation of gases, i.e., CO2 and H2S, released from underlying Carboniferous source rocks. The sediments investigated were deposited at varying distance from the southern flank of the Southern Permian Basin. Sediments near the basin margin are mainly attributed to a fluvial environment and comprise medium to coarse-grained sandstones and conglomerates. There, vermicular kaolinite occurs with a lath-like structure. Distal to the basin margin, mainly in sandstones intercalated with fine-grained playa sediments, comparatively high amounts of grain-rimming kaolinite occur. There, the presence of this mineral has a significant influence on the rock properties and the reservoir quality. Geochemical modeling suggests that the formation of such kaolinites cannot be explained exclusively by in situ feldspar dissolution. The modeling results support evidence that kaolinite can be formed from precursor clay minerals under the presence of CO2-rich formation waters. Such clay minerals could be corrensite, smectite-chlorite mixed-layer minerals, or chlorite that is potentially present in Rotliegend sediments during early diagenesis. Furthermore, the geochemical modeling can reflect several mineral reactions that were identified from petrographic analysis such as the formation of illite and kaolinite at the expense of feldspar dissolution and consequent silica

  10. The status of water and sanitation among Pacific Rim nations.

    Science.gov (United States)

    Arnold, Robert G; Heyworthz, Jane; Sáez, A Eduardo; Rodriguez, Clemencia; Weinstein, Phil; Ling, Bo; Memon, Saima

    2011-01-01

    Analysis of relationships among national wealth, access to improved water supply and sanitation facilities, and population health indices suggests that the adequacy of water resources at the national level is a poor predictor of economic development--namely, that low water stress is neither necessary nor sufficient for economic development at the present state of water stress among Pacific Rim nations. Although nations differ dramatically in terms of priority provided to improved water and sanitation, there is some level of wealth (per capita GNP) at which all nations promote the development of essential environmental services. Among the Pacific Rim countries for which there are data, no nation with a per capita GNP > US$18,000 per year has failed to provide near universal access to improved water supply and sanitation. Below US$18,000/person-year, however, there are decided differences in the provision of sanitary services (improved water supply and sanitation) among nations with similar economic success. There is a fairly strong relationship between child mortality/life expectancy and access to improved sanitation, as expected from the experiences of developed nations. Here no attempt is made to produce causal relationships among these data. Failure to meet Millennium Development Goals for the extension of improved sanitation is frequently evident in nations with large rural populations. Under those circumstances, capital intensive water and sanitation facilities are infeasible, and process selection for water/wastewater treatment requires an adaptation to local conditions, the use of appropriate materials, etc., constraints that are mostly absent in the developed world. Exceptions to these general ideas exist in water-stressed parts of developed countries, where water supplies are frequently augmented by water harvesting, water reclamation/reuse, and the desalination of brackish water resources. Each of these processes involves public acceptance of water

  11. ‘Sutureless’ transconjunctival approach for infraorbital rim fractures

    Science.gov (United States)

    Nagaraj, Vaibhav; Ghosh, Abhishek; Nanjappa, Madan; Ramesh, Keerthi

    2015-01-01

    Aim: To analyze the ease and surgical outcome of using sutureless transconjunctival approach for repair of infra-orbital fractures. Design: Prospective clinical case series. Materials and Methods: Totally 5 patients with infra-orbital rim or orbital floor fractures were selected and the fractures were accessed through a pre-septal transconjunctival incision. After reduction and fixation, the conjunctiva was just re-approximated and re-draped into position. Incidence of post-operative complications such as diplopia, lid retraction, eyelid dystopia, foreign body granuloma and poor conjunctival healing was assessed at intervals of 1 week, 15 days and a month post-operatively. Results: No complications were observed in any of the 5 patients. Healing was satisfactory in all patients. Conclusion: The sutureless technique appears to be a time saving and technically simpler viable alternative to multilayered suturing in orbital trauma with minimal post-operative complications. PMID:25821377

  12. Mass Movement on Vesta at Steep Scarps and Crater Rims

    Science.gov (United States)

    Krohn, K.; Jaumann, R.; Otto, K.; Hoogenboom, T.; Wagner, R.; Buczkowski, D. L.; Garry, B.; Williams, D. A.; Yingst, R. A.; Scully, J.; De Sanctis, M. C.; Kneissl, T.; Schmedemann, N.; Kersten, E.; Stephan, K.; Matz, K.-D.; Pieters, C. M.; Preusker, F.; Roatsch, T.; Schenk, P.; Russell, C. T.; Raymond, C. A.

    2014-01-01

    The Quadrangles Av-11 and Av-12 on Vesta are located at the northern rim of the giant Rheasilvia south polar impact basin. The primary geologic units in Av-11 and Av-12 include material from the Rheasilvia impact basin formation, smooth material and different types of impact crater structures (such as bimodal craters, dark and bright crater ray material and dark ejecta material). Av-11 and Av-12 exhibit almost the full range of mass wasting features observed on Vesta, such as slump blocks, spur-and-gully morphologies and landslides within craters. Processes of collapse, slope instability and seismically triggered events force material to slump down crater walls or scarps and produce landslides or rotational slump blocks. The spur-and-gully morphology that is known to form on Mars is also observed on Vesta; however, on Vesta this morphology formed under dry conditions.

  13. Radiation hydrodynamical models of the inner rim in protoplanetary disks

    CERN Document Server

    Flock, M; Turner, N J; Benisty, M

    2016-01-01

    Many stars host planets orbiting within a few astronomical units (AU). The occurrence rate and distributions of masses and orbits vary greatly with the host stars mass. These close planets origins are a mystery that motivates investigating protoplanetary disks central regions. A key factor governing the conditions near the star is the silicate sublimation front, which largely determines where the starlight is absorbed, and which is often called the inner rim. We present the first radiation hydrodynamical modeling of the sublimation front in the disks around the young intermediate-mass stars called Herbig Ae stars. The models are axisymmetric, and include starlight heating, silicate grains sublimating and condensing to equilibrium at the local, time-dependent temperature and density, and accretion stresses parametrizing the results of MHD magneto-rotational turbulence models. The results compare well with radiation hydrostatic solutions, and prove to be dynamically stable. Passing the model disks into Monte Ca...

  14. Donor corneoscleral rim contamination by gentamicin-resistant organisms

    Directory of Open Access Journals (Sweden)

    Gopinathan Usha

    1994-01-01

    Full Text Available Gentamicin is the most widely used antibiotic in the decontamination of donor cornea for penetrating keratoplasty. However, the incidence of resistance to gentamicin is on the rise. Bacterial isolates from 178 donor corneal rims were studied for gentamicin sensitivity. The overall rate of gentamicin resistance was 63.4%. At 86.2% the Pseudomonas. species had the highest rate of resistance, followed by Streptococci at 84.6%. The high rate of gentamicin resistance encountered by us and others suggest that either addition of a second antibiotic to corneal storage media or replacement of gentamicin by an antibiotic with a broader spectrum of activity may help reduce the risk of endophthalmitis following penetrating keratoplasty

  15. Land use change in Bohai Rim: a spatialtemporal analysis

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Based on RS and GIS methods, land use information for 1985 and1995 was acquired from TM images and analyzed. Then on both spatial and temporal aspects, this paper analyzes land use change in three provinces of Hebei, Shandong and Liaoning and two municipalities of Beijing and Tianjin in the Bohai Rim covering the period of 1985 to 1995. The extent, rate, areal difference and trend of various types of land use changes in the region, as well as spatial changes of major types of land use, their distribution characteristics and regional orientation are revealed. The regional characteristics of land use are elaborated, so as to provide effective policy support for sustainable land use in the area around the Bohai Bay.

  16. Radial Internal Material Handling System (RIMS) for Circular Habitat Volumes

    Science.gov (United States)

    Howe, Alan S.; Haselschwardt, Sally; Bogatko, Alex; Humphrey, Brian; Patel, Amit

    2013-01-01

    On planetary surfaces, pressurized human habitable volumes will require a means to carry equipment around within the volume of the habitat, regardless of the partial gravity (Earth, Moon, Mars, etc.). On the NASA Habitat Demonstration Unit (HDU), a vertical cylindrical volume, it was determined that a variety of heavy items would need to be carried back and forth from deployed locations to the General Maintenance Work Station (GMWS) when in need of repair, and other equipment may need to be carried inside for repairs, such as rover parts and other external equipment. The vertical cylindrical volume of the HDU lent itself to a circular overhead track and hoist system that allows lifting of heavy objects from anywhere in the habitat to any other point in the habitat interior. In addition, the system is able to hand-off lifted items to other material handling systems through the side hatches, such as through an airlock. The overhead system consists of two concentric circle tracks that have a movable beam between them. The beam has a hoist carriage that can move back and forth on the beam. Therefore, the entire system acts like a bridge crane curved around to meet itself in a circle. The novelty of the system is in its configuration, and how it interfaces with the volume of the HDU habitat. Similar to how a bridge crane allows coverage for an entire rectangular volume, the RIMS system covers a circular volume. The RIMS system is the first generation of what may be applied to future planetary surface vertical cylinder habitats on the Moon or on Mars.

  17. OBS FOMAR POOL: Gibraltar and ALERTES-RIM experiments.

    Science.gov (United States)

    Pazos, Antonio; Martín Davila, Jose; Buforn, Elisa; Cabieces, Roberto; Santos, Jose; Sandoval, Nicolas; Roca, Antoni; Dahm, Torsten

    2016-04-01

    The Eurasian-African plate boundary crosses the called "Ibero-Maghrebian" region from the San Vicente Cape (SW Portugal) to Tunisia including the south Iberia, Alboran Sea, and northern of Morocco and Algeria. The low convergence rate at this plate boundary produces a continuous moderate seismic activity of low magnitude and shallow depth, where the occurrence of large earthquakes is separated by long time intervals, even with associated tsunamis, like the 1755 Lisbon earthquake. In this region, there are also intermediate and very deep earthquakes. Due to the fact that part of the seismic activity is located at marine areas, and also because of the poor geographic azimuthal coverage at some zones provided by the land stations (specially in the SW of the San Vicente Cape area), Royal Spanish Navy Observatory (ROA) acquired three "LOSTERN" broad band (CMG-40T sensors) OBS, manufactured by KUM (Kiel, Germany), and, more recently (2014), the Complutense University of Madrid (UCM) acquired another three with Trillium 120 sensors. All of them conform the OBS FOMAR pool. Since January to November 2014, the FOMAR pool has been deployed along the Gibraltar strait (Gibraltar experiment), in collaboration with SECEGSA (Spanish society to study the fix communication through the Gibraltar Strait), to study the local microseismicity in the Gibraltar strait area. Also, since September 2015, the FOMAR pool has been deployed for 8 months in SW of the San Vicente Cape with an hexagonal array configuration as a part of ALERTES-RIM project. In this work the some preliminary results of the Gibraltar strait and ALERTES-RIM OBS experiment are shown.

  18. 49 CFR 238.119 - Rim-stamped straight-plate wheels.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Rim-stamped straight-plate wheels. 238.119 Section... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PASSENGER EQUIPMENT SAFETY STANDARDS Safety Planning and General Requirements § 238.119 Rim-stamped straight-plate wheels. (a)(1) Except as provided in paragraph (a)(2) of...

  19. 16 CFR Figure 8 to Part 1512 - Reflectorized Bicycle Wheel Rim Abrasion Test Device

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Reflectorized Bicycle Wheel Rim Abrasion Test Device 8 Figure 8 to Part 1512 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL...—Reflectorized Bicycle Wheel Rim Abrasion Test Device EC03OC91.074...

  20. Analysis of bubble pressure in the rim region of high burnup PWR fuel

    Energy Technology Data Exchange (ETDEWEB)

    Koo, Yang Hyun; Lee, Byung Ho; Sohn, Dong Seong [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2000-02-01

    Bubble pressure in the rim region of high burnup PWR UO{sub 2} fuel has been modeled based on measured rim width, porosity and bubble density. Using the assumption that excessive bubble pressure in the rim is inversely proportional to its radius, proportionality constant is derived as a function of average pellet burnup and bubble radius. This approach is possible because the integration of the number of Xe atoms retained in the rim bubbles, which can be calculated as a function of bubble radius, over the bubble radius gives the total number of Xe atoms in the rim bubbles. Here the total number of Xe atoms in the rim bubbles can be derived from the measured Xe depletion fraction in the matrix and the calculated rim thickness. Then the rim bubble pressure is obtained as a function of fuel burnup and bubble size from the proportionality constant. Therefore, the present model can provide some useful information that would be required to analyze the behavior of high burnup PWR UO{sub 2} fuel under both normal and transient operating conditions. 28 refs., 9 figs. (Author)

  1. From Theory to Practice: "Kaizen" and the Academy of the Pacific Rim

    Science.gov (United States)

    Blasdale, Spencer

    2004-01-01

    In this article, the author profiles the Academy of the Pacific Rim Charter Public School (Hyde Park, Massachusetts) and describes the school's culture. The school's students, who are in grades 6 through 12, are surrounded by rituals, routines, and relationship-building activities. Pacific Rim's culture stems from and supports the school's…

  2. Alkoholinių gėrimų reklamos situacija Lietuvoje

    OpenAIRE

    Maknavičiūtė, Vaida

    2008-01-01

    Darbo tikslas. Išanalizuoti alkoholinių gėrimų reklamos situaciją Lietuvoje, gyventojų požiūrį į jos draudimą. Darbo uždaviniai. 1. Išanalizuoti esamą alkoholinių gėrimų reklamą. 2. Nustatyti moksleivių požiūrį į alkoholinių gėrimų reklamą. 3. Nustatyti gyventojų požiūrį į alkoholinių gėrimų reklamos draudimą. 4. Išanalizuoti esminius reklamos kūrimo principus, įvertinti jų naudojimą reklamuojant alkoholinius gėrimus. 5. Įvertinti esamos alkoholinių gėrimų reklamos atitikim...

  3. Ultrastructural Analyses of Alveolar Bone in a Patient With Osteomyelitis Secondary to Osteopetrosis: A Review of the Literature.

    Science.gov (United States)

    Mikami, Toshinari; Miake, Yasuo; Bologna-Molina, Ronell; Takeda, Yasunori

    2016-08-01

    Osteopetrosis is a generic term for generalized sclerotic conditions caused by rare genetic disorders. Decreased osteoclastic activities disturb bone remodeling, resulting in greater mineral density and greater compressive strength; therefore, bone fracture is a major physical symptom of osteopetrosis. Osteomyelitis of the maxilla or mandible is a common and well-documented complication of osteopetrosis. Local infection, such as odontogenic infection, is more likely to lead to osteomyelitis, and treatment strategies can be challenging. However, detailed ultrastructural analyses of bone from patients with osteopetrosis and odontogenic infection are limited. This report describes a case of osteomyelitis of the maxilla and mandible secondary to osteopetrosis in an adult patient and presents ultrastructural data of alveolar bone tissue analyzed by contact microradiography, electron probe microanalysis, and x-ray diffraction. Cases of osteomyelitis of the jaw secondary to osteopetrosis also are reviewed. PMID:27000409

  4. Effect of PCMI restraint on bubble size distribution in the rim structure of UO2 fuel

    International Nuclear Information System (INIS)

    Generally, the bubble size in the rim structure of UO2 is not dependent on the fuel burnup and the bubble pressure is higher than that in the equilibrium condition. However it was also observed that if the fuel pellet is not restrained, the size of the bubbles in the rim structure could be larger than that in the restraint condition. Although the wide variety of rim bubble sizes and porosities possibly result from an external restrain effect, the quantitative method to analyze the effect of PCMI restraint on bubble distribution in the rim is not available at the moment. In this paper, a method is developed which can be used to analyze the effect of PCMI restraint on the bubble distribution in the rim structure of UO2 fuel based on the data in the literatures. The total number of Xe atoms in the rim bubbles per unit rim volume could be derived by a summation of the number of Xe atoms of each rim bubble in a unit rim volume. The number of Xe atoms of each rim bubble could be calculated by the Van der Waals equation of state and the pressure expressed by p=σ+C/r, where C is an unknown constant to be determined as a function of the temperature and the burnup. On the other hand, the total number of Xe atoms in the rim bubbles per unit rim volume can also be calculated by Xe depression data. If the fuel pellet is not restrained, the uniform hydrostatic stress, σ is zero. Hence if the data of the fuel disk without a restraint is used, a constant C can be obtained at 823K and a local burnup of 90 GWd/t. Although the local burnup of PCMI restraint case is slightly different from that without PCMI restraint, the value derived above is used for the analysis of PCMI restraint case. The calculated bubble distribution with PCMI restraint was similar to the measured one. Because the effect of PCMI restraint on bubble size increased with the bubble size, the development of a large bubble was suppressed. Hence, the PCMI restraint caused a typical bubble size in the rim and

  5. Triggered Star Formation in the Orion Bright-Rimmed Clouds

    CERN Document Server

    Lee, H T; Zhang, Z W; Hu, J Y; Lee, Hsu-Tai; Zhang, Zhi-Wei; Hu, Jing-Yao

    2005-01-01

    We have developed an empirical and effective set of criteria, based on the 2MASS colors, to select candidate classical T Tauri stars (CTTS). This provides a useful tool to study the young stellar population in star-forming regions. Here we present our analysis of the bright-rimmed clouds (BRCs) B 35, B 30, IC 2118, LDN 1616, LDN 1634, and Orion East to show how massive stars interact with molecular clouds to trigger star formation. Our results support the radiation-driven implosion model in which the ionization fronts from OB stars compress a nearby cloud until the local density exceeds the critical value, thereby inducing the cloud to collapse to form stars. We find that only BRCs associated with strong IRAS 100 micron emission (tracer of high density) and H-alpha emission (tracer of ionization fronts) show signs of ongoing star formation. Relevant timescales, including the ages of O stars, expanding HII regions, and the ages of CTTS, are consistent with sequential star formation. We also find that CTTS are ...

  6. Secondary aneurysmal bone cystic change of the chondroblastoma, mistaken for a primary aneurysmal bone cyst in the patella.

    Science.gov (United States)

    Chung, Jin Wha; Lee, Hwa Sung

    2014-03-01

    A 29-year-old woman complained of a 3-month history of left knee pain without trauma history. X-ray showed a well-defined osteolytic lesion with a sclerotic margin in the patella and magnetic resonance imaging showed T1-low and T2-high signal intensity with different fluid level. Our impression was an aneurysmal bone cyst. At surgery, the lesion was a blood-filled cystic cavity, surrounded by a gray or brownish tissue. Hemorrhagic soft tissues with recognizable bone fragments were observed. Curettage and autogenous bone graft was done. Microscopically, sheets of tumor cells were intermingled with some areas of eosinophilic chondroid matrix. The tumor cells showed oval-shaped nuclei with moderate eosinophilic cytoplasm. Several multinucleated giant cells and blood filled cystic cavities were observed. The final diagnosis was a chondroblastoma with a secondary aneurysmal bone cyst. At the post-operative 1.5-year follow-up, grafted bones were well incorporated radiographically and there were no recurrent evidence or any other abnormal symptoms. PMID:24639947

  7. Secondary aneurysmal bone cystic change of the chondroblastoma, mistaken for a primary aneurysmal bone cyst in the patella.

    Science.gov (United States)

    Chung, Jin Wha; Lee, Hwa Sung

    2014-03-01

    A 29-year-old woman complained of a 3-month history of left knee pain without trauma history. X-ray showed a well-defined osteolytic lesion with a sclerotic margin in the patella and magnetic resonance imaging showed T1-low and T2-high signal intensity with different fluid level. Our impression was an aneurysmal bone cyst. At surgery, the lesion was a blood-filled cystic cavity, surrounded by a gray or brownish tissue. Hemorrhagic soft tissues with recognizable bone fragments were observed. Curettage and autogenous bone graft was done. Microscopically, sheets of tumor cells were intermingled with some areas of eosinophilic chondroid matrix. The tumor cells showed oval-shaped nuclei with moderate eosinophilic cytoplasm. Several multinucleated giant cells and blood filled cystic cavities were observed. The final diagnosis was a chondroblastoma with a secondary aneurysmal bone cyst. At the post-operative 1.5-year follow-up, grafted bones were well incorporated radiographically and there were no recurrent evidence or any other abnormal symptoms.

  8. Bone Densitometry (Bone Density Scan)

    Science.gov (United States)

    ... of DXA Bone Densitometry? What is a Bone Density Scan (DXA)? Bone density scanning, also called dual-energy x-ray absorptiometry ( ... is today's established standard for measuring bone mineral density (BMD). An x-ray (radiograph) is a noninvasive ...

  9. RIM, Munc13, and Rab3A interplay in acrosomal exocytosis

    Energy Technology Data Exchange (ETDEWEB)

    Bello, Oscar D.; Zanetti, M. Natalia [Laboratorio de Biologia Celular y Molecular, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Laboratorio de Biologia Reproductiva, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Mayorga, Luis S. [Laboratorio de Biologia Celular y Molecular, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Michaut, Marcela A., E-mail: mmichaut@fcm.uncu.edu.ar [Laboratorio de Biologia Reproductiva, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Instituto de Ciencias Basicas, Universidad Nacional de Cuyo, Mendoza (5500) (Argentina)

    2012-03-10

    Exocytosis is a highly regulated, multistage process consisting of multiple functionally definable stages, including recruitment, targeting, tethering, priming, and docking of secretory vesicles with the plasma membrane, followed by calcium-triggered membrane fusion. The acrosome reaction of spermatozoa is a complex, calcium-dependent regulated exocytosis. Fusion at multiple sites between the outer acrosomal membrane and the cell membrane causes the release of the acrosomal contents and the loss of the membranes surrounding the acrosome. Not much is known about the molecules that mediate membrane docking in this particular fusion model. In neurons, the formation of the ternary RIM/Munc13/Rab3A complex has been suggested as a critical component of synaptic vesicles docking. Previously, we demonstrated that Rab3A localizes to the acrosomal region in human sperm, stimulates acrosomal exocytosis, and participates in an early stage during membrane fusion. Here, we report that RIM and Munc13 are also present in human sperm and localize to the acrosomal region. Like Rab3A, RIM and Munc13 participate in a prefusion step before the efflux of intra-acrosomal calcium. By means of a functional assay using antibodies and recombinant proteins, we show that RIM, Munc13 and Rab3A interplay during acrosomal exocytosis. Finally, we report by electron transmission microscopy that sequestering RIM and Rab3A alters the docking of the acrosomal membrane to the plasma membrane during calcium-activated acrosomal exocytosis. Our results suggest that the RIM/Munc13/Rab3 A complex participates in acrosomal exocytosis and that RIM and Rab3A have central roles in membrane docking. -- Highlights: Black-Right-Pointing-Pointer RIM and Munc13 are present in human sperm and localize to the acrosomal region. Black-Right-Pointing-Pointer RIM and Munc13 are necessary for acrosomal exocytosis. Black-Right-Pointing-Pointer RIM and Munc13 participate before the acrosomal calcium efflux. Black

  10. Experimental investigation of the nebular formation of chondrule rims and the formation of chondrite parent bodies

    OpenAIRE

    Beitz, Eike; Blum, Jürgen; Mathieu, Romain; Pack, Andreas; Hezel, Dominik C.

    2011-01-01

    We developed an experimental setup to test the hypothesis that accretionary dust rims around chondrules formed in the solar nebula at elevated temperatures. Our experimental method allows us to form dust rims around chondrule-analogs while being levitated in an inert-gas flow. We used micrometer-sized powdered San Carlos olivine to accrete individual dust particles onto the chondrule-analog at a temperature of 1100{\\deg}C. The resulting dust-rims were analyzed by means of two different techni...

  11. Low Bone Density

    Science.gov (United States)

    ... Density Exam/Testing › Low Bone Density Low Bone Density Low bone density is when your bone density ... people with normal bone density. Detecting Low Bone Density A bone density test will determine whether you ...

  12. Out of the Blue: The Pacific Rim as a Region

    Directory of Open Access Journals (Sweden)

    Arturo Santa-Cruz

    2005-08-01

    Full Text Available In 1993, in advance of what was to be the first Asia Pacific Economic Cooperation (APEC leader’s summit, US president Bill Clinton gave a lecture at Waseda University in Japan. In his speech, Clinton called for the creation of a “community of the Pacific.” The idea of a Pacific community is neither Clinton’s nor the Democratic Party’s invention, however. In the previous decade Ronald Reagan had already used it, going even beyond later conceptualizations, by referring to the 21st century as the Pacific’s century. But Reagan's prophecy concerning the Great Ocean was not new back in the 1980s either. In 1900 then US Secretary of State John Hay wrote: “the Mediterranean is the ocean of the past, the Atlantic the ocean of the present and the Pacific is the ocean of the future.” In a more general manner, as Christopher Coker has observed, the notion of the “Century of the Pacific” is plausible because it is consistent with the idea, popularized by Hegel, that the spirit of civilization is moving toward that part of the globe. Thus, the century of the Pacific has become a kind of zeitgeist. In this paper I undertake a conceptual, historical, and theoretical journey through the “Pacific Rim” or “Asia-Pacific,” as it has been called more recently. Although I will question the utility of the term, I want to make clear that my purpose is only to undertake a critical survey of “the Pacific.” As in any trip, however, one needs a starting point. But, What is the starting point of the Pacific Rim, that geographic zone that has been compared to Pascal’s sphere: “with periphery indeterminable and a center that may be anywhere”?

  13. The Anatomy and Bulk Composition of CAI Rims in the Vigarano (CV3) Chondrite

    Science.gov (United States)

    Ruzicka, A.; Boynton, W. V.

    1993-07-01

    A striking feature of Ca,Al-rich inclusions (CAIs) in chondrites is the presence of mineralogical layers that typically form rim sequences up to 50 micrometers thick [1]. Many ideas regarding the origin of CAI rims have been proposed, but none are entirely satisfactory. The detailed mineralogy and bulk compositions of relatively unaltered CAI rims in the Vigarano (CV3) chondrite described here provide constraints on hypotheses of rim formation. Rim Mineralogy: CAIs in Vigarano consist of melilite (mel)- and spinel (sp)- rich varieties, both of which are rimmed [2]. Around mel-rich objects, the layer sequence is CAI interior --> sp-rich layer (sometimes absent) --> mel/anorthite (anor) layer --> Ti-Al-rich clinopyroxene (Tpx) layer --> Al- diopside (Al-diop) layer --> olivine (ol) +/- Al-diop layer --> host matrix. The sequence around sp-rich objects differs from this in that the mel/anor layer is absent. Both the sp-rich layer around mel-cored CAIs and the cores of sp-rich CAIs in Vigarano are largely comprised of a fine-grained (anor layer is sometimes monomineralic, consisting of mel alone, or bimineralic, consisting of both mel and anor. Where bimineralic, anor typically occurs in the outer part of the layer. In places, anor (An(sub)99-100) has partially altered to nepheline and voids. Rim mel is systematically less gehlenitic than mel in the CAI interiors, especially compared to mel in the interior adjacent to the rims. The Tpx layer (>2 and up to 15 wt% TiO2) and Al-diop layer ( sp + fo --> sp + fo + anor or mel or Tpx) that does not correspond to observed rim sequences. It thus appears that (1) the rim region did not form through crystallization of molten CAIs; and (2) rim layers did not originate solely by the crystallization of a melt layer present on a solid CAI core [4,5]. References: [1] Wark D. A. and Lovering J. F. (1977) Proc. LSC 8th, 95-112. [2] Ruzicka A. and Boynton W. V. (1991) Meteoritics, 26, 390-391. [3] Stolper E. (1982) GCA, 46, 2159

  14. Bone Cancer

    Science.gov (United States)

    ... cancer. Surgery is often the main treatment for bone cancer. Other treatments may include amputation, chemotherapy, and radiation therapy. Because bone cancer can come back after treatment, regular follow-up visits are important. NIH: National ...

  15. Application of RIMS to the study of noble gases in meteorites

    International Nuclear Information System (INIS)

    The paper examines the possibility of using Resonance Ionization Multiphoton Spectroscopy (RIMS) for individual atom counting of noble gases in meteorites. A description is given of the techniques to extract the gases from the meteorites, as well as the noble gas components. Application of RIMS to meteoritic noble gases is discussed with respect to: sample weights required for analysis, problems of adsorbed atomospheric gases on the samples, and the sensitivity of the spectrometer. (U.K.)

  16. Bestimmung der Ionisationsenergie von Actinium und Ultraspurenanalyse von Plutonium mit resonanter Ionisationsmassenspektrometrie (RIMS)

    OpenAIRE

    Waldek, Achim Marcus

    2001-01-01

    ZusammenfassungDie Resonanzionisationsmassenspektrometrie (RIMS) verbindet hohe Elementselektivität mit guter Nachweiseffizienz. Aufgrund dieser Eigenschaften ist die Methode für Ultraspurenanalyse und Untersuchungen an seltenen oder schwer handhabbaren Elementen gut geeignet. Für RIMS werden neutrale Atome mit monochromatischem Laserlicht ein- oder mehrfach resonant auf energetisch hoch liegende Niveaus angeregt und anschließend durch einen weiteren Laserstrahl oder durch ein elektrisches Fe...

  17. Fission gas release behavior in high burnup UO2 fuels with developed rim-structure

    International Nuclear Information System (INIS)

    The effect of rim structure formation and external restraint pressure on fission gas release at transient conditions has been examined by using an out-of-pile high pressure heating technique for high burnup UO2 fuels (60, 74 and 90 GWd/t), which had been irradiated in test reactors. The latter two fuels bore a developed rim structure. The maximum heating temperature was 1500 degC, and the external pressures were independently controlled in the range of 10-150 MPa. The present high burnup fuel data were compared with those of previously studied BWR fuels of 37 and 54 GWd/t with almost no rim structure. The fission gas release and bubble swelling due to the growth of grain boundary bubbles and coarsened rim bubbles were effectively suppressed by the strong restraint pressure of 150 MPa for all the fuels; however the fission gas release remarkably increased for the two high burnup fuels with the developed rim structure, even at the strong restraint conditions. From the stepwise de-pressurization tests at an isothermal condition of 1500degC, the critical external pressure, below which a large burst release due to the rapid growth and interlinkage of the bubbles abruptly begins, was increased from a 40-60 MPa level for the middle burnup fuels to a high level of 120-140 MPa for the rim-structured high burnup fuels. The high potential for transient fission gas release and bubble swelling in the rim-structured fuels was attributed to highly over-pressurized fission gases in the rim bubbles. (author)

  18. CT Guided Bone Biopsy Using a Battery Powered Intraosseous Device

    Energy Technology Data Exchange (ETDEWEB)

    Schnapauff, Dirk, E-mail: dirk.schnapauff@charite.de; Marnitz, Tim, E-mail: tim.marnitz@charite.de; Freyhardt, Patrick, E-mail: Patrick.freyhardt@charite.de; Collettini, Federico, E-mail: Federico.collettini@charite.de [Charite Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Department of Radiology (Germany); Hartwig, Kerstin, E-mail: kerstin.hartwig@charite.de [Charite Universitaetsmedizin Berlin, Campus Charite Mitte, Department of Haematology and Oncology (Germany); Joehrens, Korinna, E-mail: korinna.joehrens@charite.de [Charite Universitaetsmedizin Berlin, Campus Charite Mitte, Department of Pathology (Germany); Hamm, Bernd, E-mail: bernd.hamm@charite.de; Kroencke, Thomas, E-mail: thomas.kroencke@charite.de; Gebauer, Bernhard, E-mail: Bernhard.gebauer@charite.de [Charite Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Department of Radiology (Germany)

    2013-10-15

    Purpose: To evaluate the feasibility of a battery powered intraosseous device to perform CT-fluoroscopy guided bone biopsy. Methods: Retrospective analysis of 12 patients in whom bone specimen were acquired from different locations under CT-fluoroscopy guidance using the OnControl bone marrow biopsy system (OBM, Vidacare, Shavano Park, TX, USA). Data of the 12 were compared to a historic cohort in whom the specimen were acquired using the classic Jamshidi Needle, as reference needle using manual force for biopsy. Results: Technical success was reached in 11 of 12 cases, indicated by central localisation of the needle within the target lesion. All specimen sampled were sufficient for histopathological workup. Compared to the historical cohort the time needed for biopsy decreased significantly from 13 {+-} 6 to 6 {+-} 4 min (P = 0.0001). Due to the shortened intervention time the radiation dose (CTDI) during CT-fluoroscopy was lowered significantly from 169 {+-} 87 to 111 {+-} 54 mGy Multiplication-Sign cm (P = 0.0001). Interventional radiologists were confident with the performance of the needle especially when using in sclerotic or osteoblastic lesions. Conclusion: The OBM is an attractive support for CT-fluoroscopy guided bone biopsy which is safe tool and compared to the classical approach using the Jamshidi needle leading to significantly reduced intervention time and radiation exposure.

  19. Experimental investigation of the nebular formation of chondrule rims and the formation of chondrite parent bodies

    CERN Document Server

    Beitz, Eike; Mathieu, Romain; Pack, Andreas; Hezel, Dominik C

    2011-01-01

    We developed an experimental setup to test the hypothesis that accretionary dust rims around chondrules formed in the solar nebula at elevated temperatures. Our experimental method allows us to form dust rims around chondrule-analogs while being levitated in an inert-gas flow. We used micrometer-sized powdered San Carlos olivine to accrete individual dust particles onto the chondrule-analog at a temperature of 1100{\\deg}C. The resulting dust-rims were analyzed by means of two different techniques: one sample was investigated with non-destructive micro computer tomography, the other with a scanning electron microscope. Both methods give very similar results for the dust-rim structure and a mean dust-rim porosity of 60 percent, demonstrating that both methods are equally well suited for sample analysis. The chondrule-analog's bulk composition has no measurable effect on the accretion efficiency of the dust. We measured the chemical composition of chondrule-analog and dust-rim to check whether elemental exchange...

  20. Magnetic-Field Amplification in the Thin X-ray Rims of SN1006

    CERN Document Server

    Ressler, Sean M; Reynolds, Stephen P; Long, Knox S; Petre, Robert; Williams, Brian J; Winkler, P Frank

    2014-01-01

    Several young supernova remnants (SNRs), including SN1006, emit synchrotron X-rays in narrow filaments, hereafter thin rims, along their periphery. The widths of these rims imply 50 to $100 \\mu$G fields in the region immediately behind the shock, far larger than expected for the interstellar medium compressed by unmodified shocks, assuming electron radiative losses limit rim widths. However, magnetic-field damping could also produce thin rims. Here we review the literature on rim width calculations, summarizing the case for magnetic-field amplification. We extend these calculations to include an arbitrary power-law dependence of the diffusion coefficient on energy, $D \\propto E^{\\mu}$. Loss-limited rim widths should shrink with increasing photon energy, while magnetic-damping models predict widths almost independent of photon energy. We use these results to analyze Chandra observations of SN 1006, in particular the southwest limb. We parameterize the full widths at half maximum (FWHM) in terms of energy as FW...

  1. {sup 99m}Tc-MDP pinhole bone scintigraphic feature of fibrovascular zone: a new diagnostic sign of osteoid osteoma

    Energy Technology Data Exchange (ETDEWEB)

    Bahk, Yong Whee [Sung Ae Hospital, Seoul (Korea, Republic of); Kim, Sung Hoon; Choi, Yeong Jin [Catholic University Medical School, Seoul (Korea, Republic of)

    2007-02-15

    Osteoid osteoma is a common benign tumor. Histologically, the tumor is characterized by the presence of the nidus, fibrovascular zone (FVZ) and reactive host bone scleroses of various intensities. A nidus consists of core meshwork of osteoid trabeculae, woven bone and osteoblastic rim and a FVZ, 1-2 mm rim, is composed of loose fibrovascular tissue and nerve fibers. The nidus and FVZ are readily identifiable on pathological specimen and CT when sclerosis is not too extensive. Recently on pinhole bone scan, we observed a peculiar rim sign that denoted FVZ in a patient with pathologically proven osteoid osteoma. Not previously described the sign appears to be pathognomonic of osteoid osteoma, uniquely providing metabolic information. The finding was correlated with that of radiography, CT and MRI and low power light microscopy.

  2. PET/MR imaging of bone lesions - implications for PET quantification from imperfect attenuation correction

    Energy Technology Data Exchange (ETDEWEB)

    Samarin, Andrei [University Hospital of Zurich, Department of Medical Radiology, Zurich (Switzerland); University Hospital Zurich, Nuclear Medicine, Zurich (Switzerland); Burger, Cyrill; Crook, David W.; Burger, Irene A.; Schmid, Daniel T.; Schulthess, Gustav K. von; Kuhn, Felix P. [University Hospital of Zurich, Department of Medical Radiology, Zurich (Switzerland); Wollenweber, Scott D. [GE Healthcare, Waukesha, WI (United States)

    2012-07-15

    Accurate attenuation correction (AC) is essential for quantitative analysis of PET tracer distribution. In MR, the lack of cortical bone signal makes bone segmentation difficult and may require implementation of special sequences. The purpose of this study was to evaluate the need for accurate bone segmentation in MR-based AC for whole-body PET/MR imaging. In 22 patients undergoing sequential PET/CT and 3-T MR imaging, modified CT AC maps were produced by replacing pixels with values of >100 HU, representing mostly bone structures, by pixels with a constant value of 36 HU corresponding to soft tissue, thereby simulating current MR-derived AC maps. A total of 141 FDG-positive osseous lesions and 50 soft-tissue lesions adjacent to bones were evaluated. The mean standardized uptake value (SUVmean) was measured in each lesion in PET images reconstructed once using the standard AC maps and once using the modified AC maps. Subsequently, the errors in lesion tracer uptake for the modified PET images were calculated using the standard PET image as a reference. Substitution of bone by soft tissue values in AC maps resulted in an underestimation of tracer uptake in osseous and soft tissue lesions adjacent to bones of 11.2 {+-} 5.4 % (range 1.5-30.8 %) and 3.2 {+-} 1.7 % (range 0.2-4 %), respectively. Analysis of the spine and pelvic osseous lesions revealed a substantial dependence of the error on lesion composition. For predominantly sclerotic spine lesions, the mean underestimation was 15.9 {+-} 3.4 % (range 9.9-23.5 %) and for osteolytic spine lesions, 7.2 {+-} 1.7 % (range 4.9-9.3 %), respectively. CT data simulating treating bone as soft tissue as is currently done in MR maps for PET AC leads to a substantial underestimation of tracer uptake in bone lesions and depends on lesion composition, the largest error being seen in sclerotic lesions. Therefore, depiction of cortical bone and other calcified areas in MR AC maps is necessary for accurate quantification of tracer

  3. PREDICTION OF LOADING DISTRIBUTION AND HYDRODYNAMIC MEASUREMENTS FOR PROPELLER BLADES IN A RIM DRIVEN THRUSTER

    Institute of Scientific and Technical Information of China (English)

    CAO Qing-ming; HONG Fang-wen; TANG Deng-hai; HU Fang-lin; LU Lin-zhang

    2012-01-01

    This article presents an approach which employs a commercial Reynolds-Averaged Navier-Stokes (RANS) solver to predict the steady wake field and loading distributions for a rim driven thruster.Four different cases of propeller blades are chosen to be calculated with the presented method.The propeller blade radial circulation and chordwise circulation density distributions are analyzed.The maximum radial circulation is found at the blade tip,which is different from conventional shaft drven propeller.The numerical results indicate that there is no tip leakage vortex in rim driven propulors.But there exist the tip joint vortex and the root region vortex.Bollard characteristics are calculated by taking rim surface effect into account.From the predicted results the second case in this paper is selected as the final one to perform hydrodynamic experiment.The calculation results with empirical rim surface corrections are compared with the measurement.It shows that the developed numerical method can well predict hydrodynamic performances of the rim driven thruster.

  4. Seamless Rim-Functionalization of h-BN with Silica-Experiment and Theoretical Modeling.

    Science.gov (United States)

    Furlotti, Michele; Caputo, Riccarda; Krumeich, Frank; Nesper, Reinhard

    2015-05-18

    Boron nitride contains six-ring layers, which are isostructural to graphene, and it exhibits similar extraordinary mechanical strength. Unlike graphene, hexagonal boron nitride (h-BN) is an insulator and has some polar features that make it a perfect material for those applications graphene is not suitable for, for example, purely ionic conductors, insulating membranes, transparent coatings, composite ceramics, high oxidation resistance materials. We report here a selective rim-functionalization of h-BN with SiO2 by using the Stöber process. A closed, protruding ring of SiO2 is formed covering all edges perpendicular to the [001] zones of the h-BN stacks and thus shield the most reactive centers of BN layers. SEM and HAADF-STEM images, X-ray spectroscopy, and atomic force microscopy confirm the rim-functionalization by SiO2 . XRD demonstrates the absence of any intercalation phenomenon of BN and reveals the glassy nature of the SiO2 rims. Selected variations of synthesis and theoretical modeling both confirm that rim activation by water prior to the Stöber condensation is crucial. First-principles calculations also confirm that dangling bonds of clean BN edges merge to give interlayer bonds that make further functionalization much more difficult. The reported reaction pathway should allow for other new functionalizations of pure BN and of the rimmed SiO2 /h-BN composites. PMID:25873400

  5. Acetabular rim and surface segmentation for hip surgery planning and dysplasia evaluation

    Science.gov (United States)

    Tan, Sovira; Yao, Jianhua; Yao, Lawrence; Summers, Ronald M.; Ward, Michael M.

    2008-03-01

    Knowledge of the acetabular rim and surface can be invaluable for hip surgery planning and dysplasia evaluation. The acetabular rim can also be used as a landmark for registration purposes. At the present time acetabular features are mostly extracted manually at great cost of time and human labor. Using a recent level set algorithm that can evolve on the surface of a 3D object represented by a triangular mesh we automatically extracted rims and surfaces of acetabulae. The level set is guided by curvature features on the mesh. It can segment portions of a surface that are bounded by a line of extremal curvature (ridgeline or crestline). The rim of the acetabulum is such an extremal curvature line. Our material consists of eight hemi-pelvis surfaces. The algorithm is initiated by putting a small circle (level set seed) at the center of the acetabular surface. Because this surface distinctively has the form of a cup we were able to use the Shape Index feature to automatically extract an approximate center. The circle then expands and deforms so as to take the shape of the acetabular rim. The results were visually inspected. Only minor errors were detected. The algorithm also proved to be robust. Seed placement was satisfactory for the eight hemi-pelvis surfaces without changing any parameters. For the level set evolution we were able to use a single set of parameters for seven out of eight surfaces.

  6. Supraorbital Rim Syndrome: Definition, Surgical Treatment, and Outcomes for Frontal Headache

    Science.gov (United States)

    Fallucco, Michael A.; Janis, Jeffrey E.

    2016-01-01

    Background: Supraorbital rim syndrome (SORS) is a novel term attributed to a composite of anatomically defined peripheral nerve entrapment sites of the supraorbital rim region. The SORS term establishes a more consistent nomenclature to describe the constellation of frontal peripheral nerve entrapment sites causing frontal headache pain. In this article, we describe the anatomical features of SORS and evidence to support its successful treatment using the transpalpebral approach that allows direct vision of these sites and the intraconal space. Methods: A retrospective review of 276 patients who underwent nerve decompression or neurectomy procedures for frontal or occipital headache was performed. Of these, treatment of 96 patients involved frontal surgery, and 45 of these patients were pure SORS patients who underwent this specific frontal trigger site deactivation surgery only. All procedures involved direct surgical approach through the upper eyelid to address the nerves of the supraorbital rim at the bony rim and myofascial sites. Results: Preoperative and postoperative data from the Migraine Disability Assessment Questionnaire were analyzed with paired t test. After surgical intervention, Migraine Disability Assessment Questionnaire scores decreased significantly at 12 months postoperatively (P myofascial unit for the supraorbital rim nerves. Proper diagnosis, full anatomical site knowledge, and complete decompression allow for consistent treatment. Furthermore, the direct, transpalpebral surgical approach provides significant benefit to allow complete decompression. PMID:27536474

  7. Experimentally Produced Spinel Rims on Ca-Al-Rich Inclusion Bulk Compositions

    Science.gov (United States)

    Paque, Julie M.; Le, L.; Lofgren, G. E.

    1998-01-01

    Most Ca-Al-rich inclusions (CAls) from Allende are surrounded by a series of mineralogically distinct rim layers. Proposed modes of formation for these layers include flash heating, evaporation, and condensation. The innermost of these rim layers is generally spinel (SP), in some cases intergrown with perovskite (PV), and commonly containing varying amounts of secondary iron increasing towards the edge of the CAI. The SP or SP+PV rim is not always contiguous with the other rim layers, indicating that it is probably the result of a separate event. We have produced continuous SP rims on synthetic analogs representing Type A/B1, average Type B, and Type B2 bulk compositions by reheating a solid glass experimental charge to subliquidus crystallization temperatures. This experimental result is consistent with the formation of chondrules; and CAIs by more than one sequence of heating and cooling. Previous work indicated that prior crystallization events produced observable effects in the texture and chemistry of the final run product. Information on the nature of the heating/cooling cycles experienced by CAls and chondrules is important in modeling the environment of their formation. Additional information is contained in the original extended abstract.

  8. [Bone diseases].

    Science.gov (United States)

    Uebelhart, Brigitte; Rizzoli, René

    2016-01-13

    Calcium intake shows a small impact on bone mineral density and fracture risk. Denosumab is a more potent inhibitor of bone resorption than zoledronate. Abaloparatide, PTHrP analog, increases bone mineral density and decreases fracture incidence. Teriparatide could be delivered via a transdermic device. Romosozumab and odanacatib improve calculated bone strength. Sequential or combined treatments with denosumab and teriparatide could be of interest, but not denosumab followed by teriparatide. Fibrous dysplasia, Paget disease and hypophosphatasia are updated, as well as atypical femoral fracture and osteonecrosis of the jaw. PMID:26946704

  9. Cracking of an Aircraft Wheel Rim Made From Al-Alloy 2014-T6

    Directory of Open Access Journals (Sweden)

    G. Kosec

    2010-10-01

    Full Text Available Generally failures of different aircraft components and parts are revealed and examined by the use of non-destructive examination methods. In further detailed explanation and interpretation of failures optical and scanning electron microscopy are used. This paper deals with a problem of a crack on aircraft wheel rim made from aluminium alloy 2014-T6.The crack was observed during regular control by the maintenance unit for non-destructive examination of the Slovenian air carrier Adria Airways. The crack on the rim of an aircraft wheel investigated was a typical fatigue crack. At same time a numerous pits were found which served as stress concentrations on the rim surface.

  10. Heat transfer coefficient of wheel rim of large capacity steam turbines

    Institute of Scientific and Technical Information of China (English)

    Jinyuan SHI; Zhicheng DENG; Yu YANG; Ganwen JUN

    2008-01-01

    A way of calculating the overall equivalent heat transfer coefficient of wheel rims of large capacity steam turbines is presented. The method and formula to calculate the mean forced convection heat-transfer coefficient of the surface of the blade and for the bottom wall of the blade passage, are introduced. The heat transmission from the blade to the rim was simplified by analogy to heat transmission in the fins. A fin heat transfer model was then used to calculate the equivalent heat transfer coefficient of the blade passage. The overall equivalent heat transfer coefficient of the wheel rim was then calculated using a cylindrical surface model. A practical calculation example was presented. The pro-posed method helps determine the heat transfer bound-ary conditions in finite element analyses of temperature and thermal stress fields of steam turbine rotors.

  11. Flows in a rotor disk rim seal with a nonaxisymmetric mainstream; Hitaisho jikuryuchu no rotor disk rim seal nai no nagare

    Energy Technology Data Exchange (ETDEWEB)

    Sano, M. [Shizuoka Institute of Science and Technology, Shizuoka (Japan); Hasegawa, Y.; Kikuyama, K. [Nagoya University, Nagoya (Japan); Daikoku, T. [Nippon Steel Corp., Tokyo (Japan)

    2000-05-25

    An experimental investigation of fluid flows in a model of gas-turbine rotor disk rim seal has been carried out. The effects of outward throughflow and rotor speed were examined on the distributions of static pressure as well as velocity inside the rim seal when a mainstream was made nonaxisymmetric by stationary vanes. Measurements were made at the mainflow axial Reynolds number of 8.0 x 10{sup 4}. As a radially outward flow is forced to be generated on the rotor by centrifugal force, a radially inward flow due to a mainstream ingestion is originated on the stator of the rim seal when the throughflow rate is decreased beyond the critical value. Once the ingestion occurs locally, the static pressure is increased remarkably just behind the stationary vanes resulting in the circumferentially non-uniform distribution. But the ingestion is suppressed with the increasing throughflow rate and the static pressure distribution tends to be uniform. The critical throughflow rate was found to be about 0.8 times of the outward flow rate caused by a free disk. (author)

  12. Imaging features of hemangioma in the long bone%长骨血管瘤的影像诊断

    Institute of Scientific and Technical Information of China (English)

    彭志刚; 孙英彩; 李晓娜; 吴文娟; 崔建岭; 赵振江

    2011-01-01

    Objective To explore the imaing features of hemangioma in the long bone and improve the diagnostic level of this disease. Methods The X-ray(14 cases), CT(9 cases) and MRI(6 cases)findings of 18 patientswith histologically proven hemangioma in the long bone after surgery were retrospectively reviewed. Results Ten tumors occurred in medullary cavity or bone end(medullary type),6 on the surface of bone (periosteal type) and 3 in cortex (intracortical type). X-ray findings: among 8 cases of medullary type, 3 showed honeycomb appearance, 3 lytic areas with sclerotic borders, one purely osteolyticchanges, and 1 frosted glass; 3 cases of periosteal type showed sclerosis and thickening of the underlying cortex; 3 cases of intracortical type showed well-defined osteolytic foci. CT findings: among 6 cases of medullary type, 5 appeared as expansile lytic lesion with uneven selerotic rim (3 cases)orhoneycomb appearance (2 cases), 1 cribriform appearance in the cortical bone, 2 periostealnew bone formation in vertical radiation pattern; 1 ground-glass appearance; among 2 cases of periosteal typeone showed regular cortical thickening, and the other irregular periosteal proliferation with marrowing of medullarycavity; 1 case of intracorticaltype showed density similar to that of soft tissue, with cortical thickening and expansion . MRI findings: 2 apeared as well-defined lesions with low signal intensity on T1WI and high signal intensity on T2WI; 1 appeared as ill-defined lesion with low to intermediate signal intensity on T1 WI and T2 WI. One showed breakthrogh of cortex and formation of soft tissue mass with low signal intensity on T1 WI and high signal on T2WI. Two showed thickening of periosteumwith intermediate signal intensity in one of them and very low signal intensity in the other. Two showed abnormal signal intensity in surrounding muscles, which was high on T2 WI and intermediate on T1 WI. Conclusions The soap-bubble or honeycomb appearance is the typical radiographic

  13. Metallogenic Districts of Yangtze Cratonic Rim at the Edge of Chaos

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Combining the science of complexity with ore geology, the author puts forward a new theory of metallogenesis: "complexity and self-organized criticality of metallogenic dynamic systems", and three fundamental theories are raised for it. The ore genesis and regularity of ore formation of four metallogenic districts around the Yangtze craton in China are studied with this theory. It is found that"metallogenic districts of Yangtze cratonic rim are all at the edge of chaos". This proposition is expounded by four determinative criteria of the edge of chaos for metallogenic districts of Yangtze cratonic rim.

  14. RIM as the data base management system for a material properties data base

    Science.gov (United States)

    Karr, P. H.; Wilson, D. J.

    1984-01-01

    Relational Information Management (RIM) was selected as the data base management system for a prototype engineering materials data base. The data base provides a central repository for engineering material properties data, which facilitates their control. Numerous RIM capabilities are exploited to satisfy prototype data base requirements. Numerical, text, tabular, and graphical data and references are being stored for five material types. Data retrieval will be accomplished both interactively and through a FORTRAN interface. The experience gained in creating and exercising the prototype will be used in specifying requirements for a production system.

  15. Rim intratorácico ectópico Thoracic ectopic kidney

    OpenAIRE

    Claudinei Leôncio Beraldo; Eugênio Fernandes de Magalhães; Demétrius Tierno Martins; Douglas Silva Coutinho; Lívia Silva Tiburzio; Mário Ribeiro Neto

    2005-01-01

    O rim ectópico intratorácico é uma anomalia rara. De todas as ectopias renais é a mais rara (p = 0,005%). Relata-se um caso de ectopia renal intratorácica em um homem negro de 83 anos, que procurou atendimento médico com quadro clínico compatível com enfisema pulmonar. Foi solicitado radiograma de tórax, que evidenciou uma massa, diagnosticada por tomografia computadorizada como ectopia renal. A maioria dos casos de rim torácico aparece como uma tumoração intratorácica encontrada em radiogram...

  16. Talking Bones.

    Science.gov (United States)

    Johnson, Jaclyn; Kassing, Sharon

    2002-01-01

    Describes cooperation with the Saint Louis Zoo to provide opportunities for elementary school students to learn about bones, how animals move, what they eat, and how much they grow. Uses biofacts which include bones, skulls, and other parts to make the laboratory a hands-on experience for students. (YDS)

  17. Bone Markers

    Science.gov (United States)

    ... bone turnover: C-telopeptide (C-terminal telopeptide of type 1 collagen (CTx)) – a marker for bone resorption. It is ... resorption include: N-telopeptide (N-terminal telopeptide of type 1 collagen (NTx)) – a peptide fragment from the amino terminal ...

  18. Bone densitometry

    DEFF Research Database (Denmark)

    Ravn, Pernille; Alexandersen, P; Møllgaard, A

    1999-01-01

    The bisphosphonates have been introduced as alternatives to hormone replacement therapy (HRT) for the treatment and prevention of postmenopausal osteoporosis. The expected increasing application in at clinical practice demands cost-effective and easily handled methods to monitor the effect on bone....... The weak response at the distal forearm during antiresorptive treatment has restricted the use of bone densitometry at this region. We describe a new model for bone densitometry at the distal forearm, by which the response obtained is comparable to the response in other regions where bone densitometry...... is much more expensive and technically complicated. By computerized iteration of single X-ray absorptiometry forearm scans we defined a region with 65% trabecular bone. The region was analyzed in randomized, double-masked, placebo- controlled trials: a 2-year trial with alendronate (n = 69), a 1-year...

  19. A unified framework for producing CAI melting, Wark-Lovering rims and bowl-shaped CAIs

    Science.gov (United States)

    Liffman, Kurt; Cuello, Nicolas; Paterson, David A.

    2016-10-01

    Calcium-Aluminium inclusions (CAIs) formed in the Solar system, some 4567 million years ago. CAIs are almost always surrounded by Wark-Lovering rims (WLRs), which are a sequence of thin, mono/bi-mineralic layers of refractory minerals, with a total thickness in the range of 1-100 microns. Recently, some CAIs have been found that have tektite-like bowl-shapes. To form such shapes, the CAI must have travelled through a rarefied gas at hypersonic speeds. We show how CAIs may have been ejected from the inner solar accretion disc via the centrifugal interaction between the solar magnetosphere and the inner disc rim. They subsequently punched through the hot, inner disc rim wall at hypersonic speeds. This re-entry heating partially or completely evaporated the CAIs. Such evaporation could have significantly increased the metal abundances of the inner disc rim. High speed movement through the inner disc produced WLRs. To match the observed thickness of WLRs required metal abundances at the inner disc wall that are of order 10 times that of standard solar abundances. The CAIs cooled as they moved away from the protosun, the deduced CAI cooling rates are consistent with the CAI cooling rates obtained from experiment and observation. The speeds and gas densities required to form bowl-shaped CAIs are also consistent with the expected speeds and gas densities for larger, ˜1 cm, CAIs punching through an inner accretion disc wall.

  20. 30 CFR 56.19074 - Riding the bail, rim, bonnet, or crosshead.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Riding the bail, rim, bonnet, or crosshead. 56.19074 Section 56.19074 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL...

  1. 30 CFR 57.19074 - Riding the bail, rim, bonnet, or crosshead.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Riding the bail, rim, bonnet, or crosshead. 57.19074 Section 57.19074 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND...

  2. Significance of fracture rim zone heterogeneity for tracer transport in crystalline rock

    Science.gov (United States)

    Cvetkovic, V.

    2010-03-01

    Conducting fractures of crystalline rock are typically altered over long periods of time. The fracture rim zone, a result of these alterations, will as a rule have different physical and chemical properties from the unaltered ("fresh") rock, depending on various microscopic and macroscopic factors of the alterations. In this paper, we study the impact of rim zone heterogeneity, exemplified by a decreasing porosity trend as inferred from the Äspö Hard Rock Laboratory site (Sweden), on short- and long-term tracer transport. Our main finding is that this particular rim zone structure will have a dominant effect on transport of moderately to strongly sorbing tracers on experimental time scales and a notable effect on application time scales. The findings of this work lend further support to the interpretation of the relatively strong retention reported by Cvetkovic et al. The fracture rim zone porosity structure may provide an additional safety margin for sorbing radionuclides in crystalline rock at sites where fracture alteration is prevalent.

  3. RIMS/sup tm/ - radiological information management system: software package EI-029-S86

    Energy Technology Data Exchange (ETDEWEB)

    1988-01-01

    RIMS/sup tm/ has been developed for health physics record keeping and reporting. It provides for the management needs relating to radiological information control at a nuclear facility. The program is comprised of the following modules: Personnel Radiological Information, Radiological Work Permit, Radiation Survey Records, Access Control, ALARA Reporting, and Respirator and Survey Instrument Inventory Modules.

  4. A Unified Framework for Producing CAI Melting, Wark-Lovering Rims and Bowl-Shaped CAIs

    CERN Document Server

    Liffman, Kurt; Paterson, David A

    2016-01-01

    Calcium Aluminium Inclusions (CAIs) formed in the Solar System, some 4,567 million years ago. CAIs are almost always surrounded by Wark-Lovering Rims (WLRs), which are a sequence of thin, mono/bi-mineralic layers of refractory minerals, with a total thickness in the range of 1 to 100 microns. Recently, some CAIs have been found that have tektite-like bowl-shapes. To form such shapes, the CAI must have travelled through a rarefied gas at hypersonic speeds. We show how CAIs may have been ejected from the inner solar accretion disc via the centrifugal interaction between the solar magnetosphere and the inner disc rim. They subsequently punched through the hot, inner disc rim wall at hypersonic speeds. This re-entry heating partially or completely evaporated the CAIs. Such evaporation could have significantly increased the metal abundances of the inner disc rim. High speed movement through the inner disc produced WLRs. To match the observed thickness of WLRs required metal abundances at the inner disc wall that a...

  5. Constraints on the height of the inner disk rim in pre-main-sequence stars

    CERN Document Server

    Vinković, Dejan

    2014-01-01

    The structure of inner region of protoplanetary disks around young pre-main-sequence stars is still poorly understood. This part of the disk is shaped by various forces influencing dust and gas dynamics and by dust sublimation, which creates abrupt drops in the dust density. This region also emits a strong near-infrared excess that cannot be explained by classical accretion disk models, which suggests the existence of some unusual dust distribution or disk shape. The most prevalent explanation to date is the puffed-up inner disk rim model, where the disk exhibits an optically thin cavity around the star up to the distance of dust sublimation. The critical parameter in this model is the inner disk rim height $z_{\\rm max}$ relative to the rim's distance from the star $R_{\\rm in}$. Observations often require $z_{\\rm max}/R_{\\rm in}\\gtrsim0.2$ to reproduce the near-infrared excess in the spectra. In this paper we put together a comprehensive list of processes that can shape the inner disk rim and combined them to...

  6. 29 CFR 1910.177 - Servicing multi-piece and single piece rim wheels.

    Science.gov (United States)

    2010-07-01

    ... Standards, 29 CFR part 1926; the Agriculture Standards, 29 CFR part 1928; the Shipyard Standards, 29 CFR part 1915; or the Longshoring Standards, 29 CFR part 1918. (3) All provisions of this section apply to... 29 Labor 5 2010-07-01 2010-07-01 false Servicing multi-piece and single piece rim wheels....

  7. Incident laser modulation of a repaired damage site with a rim in fused silica rear subsurface

    Institute of Scientific and Technical Information of China (English)

    Li Li; Xiang Xia; Zu Xiao-Tao; Yuan Xiao-Dong; He Shao-Bo; Jiang Xiao-Dong; Zheng Wan-Guo

    2012-01-01

    Local CO2 laser treatment has proved to be an effective method to prevent the 351-nm laser-induced damage sitesin a fused silica surface from exponentially growing,which is responsible for limiting the lifetime of optics in high fluence laser systems.However,the CO2 laser induced ablation crater is often surrounded by a raised rim at the edge,which can also result in the intensification of transmitted ultraviolet light that may damage the downstream optics.In this work,the three-dimensional finite-difference time-domain method is developed to simulate the distribution of electrical field intensity in the vicinity of the CO2 laser mitigated damage site located in the exit subsurface of fused silica.The simulated results show that the repaired damage sites with raised rims cause more notable modulation to the incident laser than those without rims.Specifically,we present a theoretical model of using dimpled patterning to control the rim structure around the edge of repaired damage sites to avoid damage to downstream optics.The calculated results accord well with previous experimental results and the underlying physical mechanism is analysed in detail.

  8. Effects of Wheel and Hand-Rim Size on Submaximal Propulsion in Wheelchair Athletes

    NARCIS (Netherlands)

    Mason, Barry S.; Van der Woude, Lucas H. V.; Tolfrey, Keith; Lenton, John P.; Goosey-Tolfrey, Victoria L.

    2012-01-01

    MASON, B. S., L. H. V. VAN DER WOUDE, K. TOLFREY, J. P. LENTON, and V. L. GOOSEY-TOLFREY. Effects of Wheel and Hand-Rim Size on Submaximal Propulsion in Wheelchair Athletes. Med. Sci. Sports Exerc., Vol. 44, No. 1, pp. 126-134, 2012. Purpose: This study aimed to investigate the effects of fixed gear

  9. 77 FR 18997 - Rim Lakes Forest Restoration Project; Apache-Sitgreavese National Forest, Black Mesa Ranger...

    Science.gov (United States)

    2012-03-29

    ... Forest Service Rim Lakes Forest Restoration Project; Apache-Sitgreavese National Forest, Black Mesa... to meet the purpose, this project includes a site- specific, forest plan amendment to the Apache..., Overgaard, AZ 85933. Comments may also be sent via email to...

  10. Opportunities for Partnership in the Pacific Rim: Reflections on a Visit to Vietnam.

    Science.gov (United States)

    Sykes, Abel B., Jr.

    Community colleges are poised to play a vital role in Vietnam and other Pacific Rim nations currently seeking to develop their business sectors and economies. Projects and partnerships with U.S. community colleges are currently in progress in India, Malaysia, China, Japan, Taiwan, and Korea. In addition, the Vietnamese Ministry of Education and…

  11. Resource-saving technology for producing blanks wheel rims with the unit longitudinal-transverse cutting

    OpenAIRE

    Кононенко, Д. Ю.; Павлюк, А. В.; Антоненко, А. В.; Разиньков, Н. А.

    2013-01-01

    Analysis of the grade and dimensional range of original metal used in the manufacture of wheels andrims was carried out. Defined are the parameters and characteristics of rolls cutting, required for selecting aplant unit. One of the ways of increasing economical efficiency of wheel rims production was investigated,in order to optimize blanks manufacturing technology with considerations for the production program.

  12. Upper rim {alpha}-hydroxy-or {alpha}-amino phosphonic acid derivatives of calix (4) ARENES

    Energy Technology Data Exchange (ETDEWEB)

    Markovsky, L.N.; Kalchenko, V.I.; Solovyov, A.V.; Finocchiaro, P.; Failla, S.; Atamas, L.I.; Consiglio, G.; Tsymbal, I.F. [Institute of Organic Chemistry National Academy of Sciences of Ukraine (Ukraine)

    1998-10-01

    The synthesis and some stereochemical peculiarities of calix (4) arenes bearing at the upper rim of macrocycle alpha-hydroxy or alpha-amino phosphonic acid dialkyl ester fragments are described. The formation of the dimeric associates induced by intermolecular hydrogen bonds CH-OH...O=P has been also studied. (Author) 24 refs.

  13. Detection of solar wind-produced water in irradiated rims on silicate minerals.

    Science.gov (United States)

    Bradley, John P; Ishii, Hope A; Gillis-Davis, Jeffrey J; Ciston, James; Nielsen, Michael H; Bechtel, Hans A; Martin, Michael C

    2014-02-01

    The solar wind (SW), composed of predominantly ∼1-keV H(+) ions, produces amorphous rims up to ∼150 nm thick on the surfaces of minerals exposed in space. Silicates with amorphous rims are observed on interplanetary dust particles and on lunar and asteroid soil regolith grains. Implanted H(+) may react with oxygen in the minerals to form trace amounts of hydroxyl (-OH) and/or water (H2O). Previous studies have detected hydroxyl in lunar soils, but its chemical state, physical location in the soils, and source(s) are debated. If -OH or H2O is generated in rims on silicate grains, there are important implications for the origins of water in the solar system and other astrophysical environments. By exploiting the high spatial resolution of transmission electron microscopy and valence electron energy-loss spectroscopy, we detect water sealed in vesicles within amorphous rims produced by SW irradiation of silicate mineral grains on the exterior surfaces of interplanetary dust particles. Our findings establish that water is a byproduct of SW space weathering. We conclude, on the basis of the pervasiveness of the SW and silicate materials, that the production of radiolytic SW water on airless bodies is a ubiquitous process throughout the solar system.

  14. A trans-acting Variant within the Transcription Factor RIM101 Interacts with Genetic Background to Determine its Regulatory Capacity.

    Directory of Open Access Journals (Sweden)

    Timothy Read

    2016-01-01

    Full Text Available Most genetic variants associated with disease occur within regulatory regions of the genome, underscoring the importance of defining the mechanisms underlying differences in regulation of gene expression between individuals. We discovered a pair of co-regulated, divergently oriented transcripts, AQY2 and ncFRE6, that are expressed in one strain of Saccharomyces cerevisiae, ∑1278b, but not in another, S288c. By combining classical genetics techniques with high-throughput sequencing, we identified a trans-acting single nucleotide polymorphism within the transcription factor RIM101 that causes the background-dependent expression of both transcripts. Subsequent RNA-seq experiments revealed that RIM101 regulates many more targets in S288c than in ∑1278b and that deletion of RIM101 in both backgrounds abrogates the majority of differential expression between the strains. Strikingly, only three transcripts undergo a significant change in expression after swapping RIM101 alleles between backgrounds, implying that the differences in the RIM101 allele lead to a remarkably focused transcriptional response. However, hundreds of RIM101-dependent targets undergo a subtle but consistent shift in expression in the S288c RIM101-swapped strain, but not its ∑1278b counterpart. We conclude that ∑1278b may harbor a variant(s that buffers against widespread transcriptional dysregulation upon introduction of a non-native RIM101 allele, emphasizing the importance of accounting for genetic background when assessing the impact of a regulatory variant.

  15. 76 FR 69720 - NaturEner Rim Rock Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

    Science.gov (United States)

    2011-11-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission NaturEner Rim Rock Wind Energy, LLC; Supplemental Notice That Initial Market... in the above-referenced proceeding of NaturEner Rim Rock Wind Energy, LLC's application for...

  16. A trans-acting Variant within the Transcription Factor RIM101 Interacts with Genetic Background to Determine its Regulatory Capacity.

    Science.gov (United States)

    Read, Timothy; Richmond, Phillip A; Dowell, Robin D

    2016-01-01

    Most genetic variants associated with disease occur within regulatory regions of the genome, underscoring the importance of defining the mechanisms underlying differences in regulation of gene expression between individuals. We discovered a pair of co-regulated, divergently oriented transcripts, AQY2 and ncFRE6, that are expressed in one strain of Saccharomyces cerevisiae, ∑1278b, but not in another, S288c. By combining classical genetics techniques with high-throughput sequencing, we identified a trans-acting single nucleotide polymorphism within the transcription factor RIM101 that causes the background-dependent expression of both transcripts. Subsequent RNA-seq experiments revealed that RIM101 regulates many more targets in S288c than in ∑1278b and that deletion of RIM101 in both backgrounds abrogates the majority of differential expression between the strains. Strikingly, only three transcripts undergo a significant change in expression after swapping RIM101 alleles between backgrounds, implying that the differences in the RIM101 allele lead to a remarkably focused transcriptional response. However, hundreds of RIM101-dependent targets undergo a subtle but consistent shift in expression in the S288c RIM101-swapped strain, but not its ∑1278b counterpart. We conclude that ∑1278b may harbor a variant(s) that buffers against widespread transcriptional dysregulation upon introduction of a non-native RIM101 allele, emphasizing the importance of accounting for genetic background when assessing the impact of a regulatory variant.

  17. Calculation of ejecta thickness and structural uplift for Lunar and Martian complex crater rims.

    Science.gov (United States)

    Krüger, Tim; Sturm, Sebastian; Kenkmann, Thomas

    2014-05-01

    Crater rims of simple and complex craters have an elevation that is formed during the excavation stage of crater formation. For simple crater rims it is believed that the elevation is due to the sum of two equal parts, the thickness of the most proximal impact ejecta blanket (overturned flap) plus the thickness that results from plastic deformation including injection [1, 2, 3]. We intend to measure and quantify the kinematics of mass movements, especially concerning the question why complex impact craters have elevated crater rims like simple craters and precisely constrain the ejecta thickness and structural uplift of Lunar and Martian crater rims to understand what the main contributor to the elevated rim is [4]. We investigated a pristine 16 km-diameter unnamed Martian complex crater (21.52°N, 184.35°) and the lunar complex craters Bessel (21.8°N, 17.9°E) 16 km in diameter and Euler (23.3°N, 29.2°W) 28 km in diameter [5, 6]. In the crater walls of these craters we found columnar lavas on Mars and basaltic layering on the Moon. We used the uppermost layers of these exposed outcrops along the crater wall to determine the dip of the target rocks (Mars) and to distinguish between the bedrock and the overlying ejecta. We precisely measured the structural uplift and ejecta thickness of these complex craters. The unnamed crater on Mars has a mean rim height of 375.75 m, with a structural uplift of 233.88 m (57.44%), exposed as columnar lavas and the superposing ejecta has a height of 141.87 m (43.56%). For the Lunar complex crater Euler the mean total rim height is 790 ± 100 m, with a minimal structural uplift of 475 ± 100 m (60 ± 10 %), exposed as basaltic layers [e.g., 7, 8] and a maximum ejecta thickness of 315 ± 100 m (40 ± 10%). The Lunar complex crater Bessel has a total rim height of 430 ± 15 m , with a minimal structural uplift of 290 ± 15 m (67 ± 3 %), exposed as basaltic layers and a maximum ejecta thickness of 140 ± 115 m (33 ± 3%). For the

  18. Your Bones

    Science.gov (United States)

    ... a fall! If you play sports like football, soccer, lacrosse, or ice hockey, always wear all the ... to strengthen your bones is through exercise like running, jumping, dancing, and playing sports. Take these steps ...

  19. The diagnosis and therapeutics of the juxta-articular bone cyst in the acetabulum%髋臼邻关节骨囊肿的诊断与治疗

    Institute of Scientific and Technical Information of China (English)

    李伟栩; 严世贵; 叶招明; 陶惠民; 林秾; 杨迪生

    2010-01-01

    Objective To discuss the diagnosis, differential diagnosis and therapeutics of the juxtaarticular bone cyst in the acetabulum. Methods Between August 1990 to April 2009, nineteen cases of clinical data of the juxta-articular bone cyst in the acetabulum data were collected from hospital records and analyzed retrospectively. There were 11 males and 8 females, with an average age of 42.3 years (range, 18-59). Seventeen patients felt an aching pain in the hip. The duration of symptoms was from 2 months to 20years with the median 15 months. All the radiographs showed a well-demarcated oval or circular radiolucent defect, close to subchondral bone, and outlined by a thin rim of sclerotic bone. Five cases accompanied with developmental dysplasia of the hip. After curettage of the bone cyst, 14 patients received iliac crest autogenous bone grafts, 3 patients received xenoma spongy bone-graft particles, and 2 patients received artificial bone grafts. Results Fourteen patients were precisely diagnosed as bone cyst by radiograph, and 4 patients were diagnosed by CT and MRI. The major axes of the focus were 2-4 cm in 16 patients, and 4-8 cm in 3patients. The sizes of the focus had no relationship with the symptoms and the course of the disease. Seventeen cases of the focus were located at the anterior superior of the bearing surface of the acetabulum. All patients were successfully followed up from 11 months to 13 years, averaged 6.2 years, and no relapses occurred during the follow-up period in every case. Fourteen patients felt asymptomatic, 3 patients felt uncomfortable in hip occasionally, and 2 patients with developmental dysplasia of the hip felt ameliorated in the initial stage of the therapy, followed by aggravation accompanying the hip joint space narrow. Conclusion Bone graft after thorough curettage of the capsular space was an effective therapy for the juxta-articular bone cyst in the acetabulum, and the anatomic distribution of radiological lesions indicated that

  20. Bone marrow transplant

    Science.gov (United States)

    Transplant - bone marrow; Stem cell transplant; Hematopoietic stem cell transplant; Reduced intensity nonmyeloablative transplant; Mini transplant; Allogenic bone marrow transplant; Autologous bone marrow transplant; Umbilical ...

  1. A magnetic resonance imaging study on changes in rat mandibular bone marrow and pulp tissue after high-dose irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Wan; Lee, Byung Do [Dept. of Oral and Maxillofacial Radiology and Wonkwang Dental Research Institute, College of Dentistry, Wonkwang University, Iksan (Korea, Republic of); Lee, Kang Kyoo [Dept. of Radiation Oncology, School of Medicine, Wonkwang University, Iksan (Korea, Republic of); Koh, Kwang Joon [Dept. of Oral and Maxillofacial Radiology, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju (Korea, Republic of)

    2014-03-15

    This study was designed to evaluate whether magnetic resonance imaging (MRI) is appropriate for detecting early changes in the mandibular bone marrow and pulp tissue of rats after high-dose irradiation. The right mandibles of Sprague-Dawley rats were irradiated with 10 Gy (Group 1, n=5) and 20 Gy (Group 2, n=5). Five non-irradiated animals were used as controls. The MR images of rat mandibles were obtained before irradiation and once a week until week 4 after irradiation. From the MR images, the signal intensity (SI) of the mandibular bone marrow and pulp tissue of the incisor was interpreted. The MR images were compared with the histopathologic findings. The SI of the mandibular bone marrow had decreased on T2-weighted MR images. There was little difference between Groups 1 and 2. The SI of the irradiated groups appeared to be lower than that of the control group. The histopathologic findings showed that the trabecular bone in the irradiated group had increased. The SI of the irradiated pulp tissue had decreased on T2-weighted MR images. However, the SI of the MR images in Group 2 was high in the atrophic pulp of the incisor apex at week 2 after irradiation. These patterns seen on MRI in rat bone marrow and pulp tissue were consistent with histopathologic findings. They may be useful to assess radiogenic sclerotic changes in rat mandibular bone marrow.

  2. A magnetic resonance imaging study on changes in rat mandibular bone marrow and pulp tissue after high-dose irradiation

    International Nuclear Information System (INIS)

    This study was designed to evaluate whether magnetic resonance imaging (MRI) is appropriate for detecting early changes in the mandibular bone marrow and pulp tissue of rats after high-dose irradiation. The right mandibles of Sprague-Dawley rats were irradiated with 10 Gy (Group 1, n=5) and 20 Gy (Group 2, n=5). Five non-irradiated animals were used as controls. The MR images of rat mandibles were obtained before irradiation and once a week until week 4 after irradiation. From the MR images, the signal intensity (SI) of the mandibular bone marrow and pulp tissue of the incisor was interpreted. The MR images were compared with the histopathologic findings. The SI of the mandibular bone marrow had decreased on T2-weighted MR images. There was little difference between Groups 1 and 2. The SI of the irradiated groups appeared to be lower than that of the control group. The histopathologic findings showed that the trabecular bone in the irradiated group had increased. The SI of the irradiated pulp tissue had decreased on T2-weighted MR images. However, the SI of the MR images in Group 2 was high in the atrophic pulp of the incisor apex at week 2 after irradiation. These patterns seen on MRI in rat bone marrow and pulp tissue were consistent with histopathologic findings. They may be useful to assess radiogenic sclerotic changes in rat mandibular bone marrow.

  3. Rim versus Non-Rim States in the Arctic Region: Prospects for a Zero-Sum Game or a Win-Win One?

    Directory of Open Access Journals (Sweden)

    Ana-Maria Ghimiş

    2013-09-01

    Full Text Available The present paper aims to develop a critical approach on one of the most urgent energy security challenges: the Arctic region. Until recently, it was considered to be a frozen desert, upon which no one raised any legal demands or interests. The global warming, the technological development and the increased need for energy resources had transformed the frozen High North into a very hot spot, where states like US, Canada, Norway, Denmark or Russia started an energy race that threatens to escalate. The Arctic became a strategic area given its opportunities: besides the energy resources, new commercial routes could become available for a longer period of time. But, due to legal uncertainties, the lack of coherent and direct legal procedures of international law, the Arctic game is an open one, in which any state can intervene and ask for a solution that is suitable for its interests. This aspect complicates even further the already unstable region. Some of the actors see the region as an international area, as a common good, where everyone has the right to explore or exploit, while the rim states see the Arctic in sovereign rights terms. Therefore, the game tends to complicate as non-rim players (the EU, China, Japan, NATO and South Korea want to intervene in the region and try to influence its development.

  4. Space Plasma Ion Processing of the Lunar Soil: Modeling of Radiation-Damaged Rim Widths on Lunar Grains

    Science.gov (United States)

    Chamberlin, S.; Christoffersen, R.; Keller, L.

    2007-01-01

    Chemically and microstructurally complex altered rims around grains in the finest size fraction (radiation damage and nanoscale deposition of impact or sputter-derived vapors. The formation of the rims is an important part of the space weathering process, and is closely linked to key changes in optical reflectance and other bulk properties of the lunar surface. Recent application of field-emission scanning transmission electron microscope techniques, including energy dispersive X-ray spectral imaging, is making it easier to unravel the "nano-stratigraphy" of grain rims, and to delineate the portions of rims that represent Radiation-Amorphized (RA) host grain from overlying amorphous material that represents vapor/sputter deposits. For the portion of rims formed by host grain amorphization (henceforth called RA rims), we have been investigating the feasibility of using Monte Carlo-type ion-atom collision models, combined with experimental ion irradiation data, to derive predictive numerical models linking the width of RA rims to the grain s integrated solar ion radiation exposure time.

  5. Bone mineral content and bone metabolism in young adults with severe periodontitis

    DEFF Research Database (Denmark)

    Wowern von, N.; Westergaard, J.; Kollerup, G.

    2001-01-01

    Bone loss, bone markers, bone metabolism, bone mineral content, osteoporosis, severe periodontitis......Bone loss, bone markers, bone metabolism, bone mineral content, osteoporosis, severe periodontitis...

  6. Effect of power-assisted hand-rim wheelchair propulsion on shoulder load in experienced wheelchair users: A pilot study with an instrumented wheelchair

    NARCIS (Netherlands)

    Kloosterman, M.G.M.; Buurke, J.H.; Vries, de W.; Woude, van der L.H.V.; Rietman, J.S.

    2015-01-01

    This study aims to compare hand-rim and power-assisted hand-rim propulsion on potential risk factors for shoulder overuse injuries: intensity and repetition of shoulder loading and force generation in the extremes of shoulder motion. Eleven experienced hand-rim wheelchair users propelled an instrume

  7. The C-terminal Cytosolic Region of Rim21 Senses Alterations in Plasma Membrane Lipid Composition: INSIGHTS INTO SENSING MECHANISMS FOR PLASMA MEMBRANE LIPID ASYMMETRY.

    Science.gov (United States)

    Nishino, Kanako; Obara, Keisuke; Kihara, Akio

    2015-12-25

    Yeast responds to alterations in plasma membrane lipid asymmetry and external alkalization via the sensor protein Rim21 in the Rim101 pathway. However, the sensing mechanism used by Rim21 remains unclear. Here, we found that the C-terminal cytosolic domain of Rim21 (Rim21C) fused with GFP was associated with the plasma membrane under normal conditions but dissociated upon alterations in lipid asymmetry or external alkalization. This indicates that Rim21C contains a sensor motif. Rim21C contains multiple clusters of charged residues. Among them, three consecutive Glu residues (EEE motif) were essential for Rim21 function and dissociation of Rim21C from the plasma membrane in response to changes in lipid asymmetry. In contrast, positively charged residues adjacent to the EEE motif were required for Rim21C to associate with the membrane. We therefore propose an "antenna hypothesis," in which Rim21C moves to or from the plasma membrane and functions as the sensing mechanism of Rim21.

  8. Effect of power-assisted hand-rim wheelchair propulsion on shoulder load in experienced wheelchair users : A pilot study with an instrumented wheelchair

    NARCIS (Netherlands)

    Kloosterman, Marieke G. M.; Buurke, Jaap H.; de Vries, Wiebe; Van der Woude, Lucas H. V.; Rietman, Johan S.

    2015-01-01

    This study aims to compare hand-rim and power-assisted hand-rim propulsion on potential risk factors for shoulder overuse injuries: intensity and repetition of shoulder loading and force generation in the extremes of shoulder motion. Eleven experienced hand-rim wheelchair users propelled an instrume

  9. Study of the three-dimensional orientation of the labrum: its relations with the osseous acetabular rim

    Science.gov (United States)

    Bonneau, Noémie; Bouhallier, July; Baylac, Michel; Tardieu, Christine; Gagey, Olivier

    2012-01-01

    Understanding the three-dimensional orientation of the coxo-femoral joint remains a challenge as an accurate three-dimensional orientation ensure an efficient bipedal gait and posture. The quantification of the orientation of the acetabulum can be performed using the three-dimensional axis perpendicular to the plane that passes along the edge of the acetabular rim. However, the acetabular rim is not regular as an important indentation in the anterior rim was observed. An innovative cadaver study of the labrum was developed to shed light on the proper quantification of the three-dimensional orientation of the acetabulum. Dissections on 17 non-embalmed corpses were performed. Our results suggest that the acetabular rim is better represented by an anterior plane and a posterior plane rather than a single plane along the entire rim as it is currently assumed. The development of the socket from the Y-shaped cartilage was suggested to explain the different orientations in these anterior and posterior planes. The labrum forms a plane that takes an orientation in between the anterior and posterior parts of the acetabular rim, filling up inequalities of the bony rim. The vectors VL, VA2 and VP, representing the three-dimensional orientation of the labrum, the anterior rim and the posterior rim, are situated in a unique plane that appears biomechanically dependent. The three-dimensional orientation of the acetabulum is a fundamental parameter to understand the hip joint mechanism. Important applications for hip surgery and rehabilitation, as well as for physical anthropology, were discussed. PMID:22360458

  10. [Bone transplant].

    Science.gov (United States)

    San Julián, M; Valentí, A

    2006-01-01

    We describe the methodology of the Bone and Soft Tissue Bank, from extraction and storage until use. Since the year 1986, with the creation of the Bone Bank in the University Clinic of Navarra, more than 3,000 grafts have been used for very different types of surgery. Bone grafts can be classified into cortical and spongy; the former are principally used in surgery to save tumour patients, in large post-traumatic reconstructions and in replacement surgery where there are massive bone defects and a structural support is required. The spongy grafts are the most used due to their numerous indications; they are especially useful in filling cavities that require a significant quantity of graft when the autograft is insufficient, or as a complement. They are also of special help in treating fractures when there is bone loss and in the treatment of delays in consolidation and pseudoarthrosis in little vascularized and atrophic zones. They are also used in prosthetic surgery against the presence of cavity type defects. Allografts of soft tissues are specially recognised in multiple ligament injuries that require reconstructions. Nowadays, the most utilised are those employed in surgery of the anterior cruciate ligament although they can be used for filling any ligament or tendon defect. The principal difficulties of the cortical allografts are in the consolidation of the ends with the bone itself and in tumour surgery, given that these are patients immunodepressed by the treatment, the incidence of infection is increased with respect to spongy grafts and soft tissues, which is irrelevant. In short, the increasingly widespread use of allografts is an essential therapeutic weapon in orthopaedic surgery and traumatology. It must be used by expert hands.

  11. [Bone transplant].

    Science.gov (United States)

    San Julián, M; Valentí, A

    2006-01-01

    We describe the methodology of the Bone and Soft Tissue Bank, from extraction and storage until use. Since the year 1986, with the creation of the Bone Bank in the University Clinic of Navarra, more than 3,000 grafts have been used for very different types of surgery. Bone grafts can be classified into cortical and spongy; the former are principally used in surgery to save tumour patients, in large post-traumatic reconstructions and in replacement surgery where there are massive bone defects and a structural support is required. The spongy grafts are the most used due to their numerous indications; they are especially useful in filling cavities that require a significant quantity of graft when the autograft is insufficient, or as a complement. They are also of special help in treating fractures when there is bone loss and in the treatment of delays in consolidation and pseudoarthrosis in little vascularized and atrophic zones. They are also used in prosthetic surgery against the presence of cavity type defects. Allografts of soft tissues are specially recognised in multiple ligament injuries that require reconstructions. Nowadays, the most utilised are those employed in surgery of the anterior cruciate ligament although they can be used for filling any ligament or tendon defect. The principal difficulties of the cortical allografts are in the consolidation of the ends with the bone itself and in tumour surgery, given that these are patients immunodepressed by the treatment, the incidence of infection is increased with respect to spongy grafts and soft tissues, which is irrelevant. In short, the increasingly widespread use of allografts is an essential therapeutic weapon in orthopaedic surgery and traumatology. It must be used by expert hands. PMID:16998521

  12. Raman spectroscopic characterization of the core-rim structure in reaction bonded boron carbide ceramics

    Energy Technology Data Exchange (ETDEWEB)

    Jannotti, Phillip; Subhash, Ghatu, E-mail: subhash@ufl.edu [Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida 32611 (United States); Zheng, James Q.; Halls, Virginia [Program Executive Office—Soldier Protection and Individual Equipment, US Army, Fort Belvoir, Virginia 22060 (United States); Karandikar, Prashant G.; Salamone, S.; Aghajanian, Michael K. [M-Cubed Technologies, Inc., Newark, Delaware 19711 (United States)

    2015-01-26

    Raman spectroscopy was used to characterize the microstructure of reaction bonded boron carbide ceramics. Compositional and structural gradation in the silicon-doped boron carbide phase (rim), which develops around the parent boron carbide region (core) due to the reaction between silicon and boron carbide, was evaluated using changes in Raman peak position and intensity. Peak shifting and intensity variation from the core to the rim region was attributed to changes in the boron carbide crystal structure based on experimental Raman observations and ab initio calculations reported in literature. The results were consistent with compositional analysis determined by energy dispersive spectroscopy. The Raman analysis revealed the substitution of silicon atoms first into the linear 3-atom chain, and then into icosahedral units of the boron carbide structure. Thus, micro-Raman spectroscopy provided a non-destructive means of identifying the preferential positions of Si atoms in the boron carbide lattice.

  13. Theoretical and experimental research of hammer forging process of RIM from AZ31 magnesium alloy

    Directory of Open Access Journals (Sweden)

    A. Gontarz

    2014-10-01

    Full Text Available The results of theoretical analysis and experimental tests of hammer forging process of rim part from AZ31 magnesium alloy are presented in this paper. On the basis of numerical simulation results, the analysis of limiting phenomena was made. These phenomena include: possibility of overlapping presence, not filling of die impression, overheating of material and cracks. The results of theoretical analysis provided the support for planning of experimental tests in industrial conditions. Forging tests were conducted in one of Polish forming plants, applying steam-air hammer of blow energy 63 kJ. On the basis of experimental verification, it was stated that it is possible to obtain rim forging from AZ31 alloy of assumed quality in the hammer forging process.

  14. Asia/Pacific Rim renewable energy market assessments by the State of Hawaii

    International Nuclear Information System (INIS)

    The State of Hawaii has begun to encourage its economic growth and diversification by increasing the export of U.S. energy, environment, ocean, and information technologies. Hawaii's Strategic Technology Market Assessment and Development (STMAD) program promotes the transfer of U.S. technology into Asia and the Pacific Rim, locations having phenomenal growth potential and vast technological infrastructure demands. The STMAD program is managed by the State's Department of Business, Economic Development and Tourism (DBEDT). Under the auspices of STMAD, the Hawaii Natural Energy Institute (HNEI) of the University of Hawaii is assessing biomass energy resources of Asian and Pacific Rim countries to identify and investigate sustainable energy markets. This paper reviews the STMAD program and reports findings of renewable energy assessment performed by HNEI and DBEDT. (author)

  15. A New Mechanism of Formation of the Silver—Rim Structure on Primary Gold Grains

    Institute of Scientific and Technical Information of China (English)

    陆建军; 王汝成; 等

    2000-01-01

    Gold minerals in the Baochun skarn-type gold deposit are Au-Ag allogy with Ag contents within the range of 15-35.5wt% and the inerals vary from 5μm to 50μm in size.As viewed from the electron microprobe images,most gold grains show silver rims with a high Ag content as compared with the core,ranging generally from 2 to 3μm in width.From dynamic calculations based on the mass action and mass balance constratints on the crystallization of native gold,it is considered that the enrichment of silver in the rim of gold minerals in due to gradual enrichment of silver in the ore-forming solutions with its evolution from the early to the late metallogenic stage.

  16. Ammonia observations of bright-rimmed clouds: establishing a sample of triggered protostars

    CERN Document Server

    Morgan, L K; Urquhart, J S; Thompson, M A

    2010-01-01

    We observed 42 molecular condensations within previously identified bright-rimmed clouds in the ammonia rotational inversion lines NH3 (1,1), (2,2), (3,3) and (4,4) using the Green Bank Telescope in Green Bank, West Virginia. Using the relative peaks of the ammonia lines and their hyperfine satellites we have determined important parameters of these clouds, including rotational temperatures and column densities. These observations confirm the presence of dense gas towards IRAS point sources detected at submillimetre wavelengths. Derived physical properties allow us to refine the sample of bright-rimmed clouds into those likely to be sites of star formation, triggered via the process of radiatively-driven implosion. An investigation of the physical properties of our sources show that triggered sources are host to greater turbulent velocity dispersions, likely indicative of shock motions within the cloud material. These may be attributed to the passage of triggered shocks or simply the association of outflow ac...

  17. Silicon and oxygen self-diffusion in enstatite polycrystals: the Milke et al. (2001) rim growth experiments revisited

    OpenAIRE

    Abart, R.; K. Kunze; R. Milke; R. Sperb; Wilhelm Heinrich;  

    2004-01-01

    Milke et al. (Contrib Mineral Petrol 142: 15-26, 2001) studied the diffusion of Si, Mg and O in synthetic polycrystalline enstatite reaction rims. The reaction rims were grown at 1000°C and 1 GPa at the contacts between forsterite grains with normal isotopic compositions and a quartz matrix extremely enriched in 18O and 29Si. The enstatite reaction rim grew from the original quartz-forsterite interface in both directions producing an inner portion, which replaced forsterite and an outer porti...

  18. What Is Bone?

    Science.gov (United States)

    ... by your browser. Home Bone Basics What Is Bone? Publication available in: PDF (57 KB) Related Resources ... Men, and Osteoporosis Osteoporosis Prevention For Your Information Bone Remodeling Throughout life, bone is constantly renewed through ...

  19. Calcium and bones

    Science.gov (United States)

    Bone strength and calcium ... calcium (as well as phosphorus) to make healthy bones. Bones are the main storage site of calcium in ... your body does not absorb enough calcium, your bones can get weak or will not grow properly. ...

  20. Facts about Broken Bones

    Science.gov (United States)

    ... White House Lunch Recipes The Facts About Broken Bones KidsHealth > For Kids > The Facts About Broken Bones ... through the skin . continue What Happens When a Bone Breaks? It hurts to break a bone! It's ...

  1. Bone biopsy (image)

    Science.gov (United States)

    A bone biopsy is performed by making a small incision into the skin. A biopsy needle retrieves a sample of bone and it ... examination. The most common reasons for bone lesion biopsy are to distinguish between benign and malignant bone ...

  2. Bone lesion biopsy

    Science.gov (United States)

    Bone biopsy; Biopsy - bone ... is sent to a lab for examination. Bone biopsy may also be done under general anesthesia to ... remove the bone can be done if the biopsy exam shows that there is an abnormal growth ...

  3. Mineral resources of the Massacre Rim Wilderness Study Area, Washoe County, Nevada

    International Nuclear Information System (INIS)

    The Massacre Rim Wilderness Study Area encompasses 23,260 acres in Northwest Nevada. There is moderate mineral resource potential for gold, silve, and mercury in hydrothermal deposits in the eastern part of the study area. There is moderate mineral resource potential for uranium throughout the study area. There is no potential for oil and gas in the study area. The potential for geothermal resources is unknown

  4. 78 FR 15920 - Federal Motor Vehicle Safety Standards; Tire Selection and Rims

    Science.gov (United States)

    2013-03-13

    ...This document proposes to amend Federal Motor Vehicle Safety Standard (FMVSS) No. 110 to make it clear that special trailer (ST) tires are permitted to be installed on new trailers with a gross vehicle weight rating (GVWR) of 4,536 kg (10,000 lbs.) or less. It also proposes to exclude these trailers from a vehicle testing requirement that a tire must be retained on its rim when subjected to a......

  5. Training the next generation of global health experts: experiences and recommendations from Pacific Rim universities

    OpenAIRE

    Withers, Mellissa; Press, David; Wipfli, Heather; McCool, Judith; Chan, Chang-Chuan; Jimba, Masamine; Tremewan, Christopher; Samet, Jonathan

    2016-01-01

    Background Finding solutions to global health problems will require a highly-trained, inter-disciplinary workforce. Global health education and research can potentially have long-range impact in addressing the global burden of disease and protecting and improving the health of the global population. Methods We conducted an online survey of twelve higher education institutions in the Pacific Rim that spanned the period 2005–2011. Program administrators provided data on program concentrations, ...

  6. Cracking of an Aircraft Wheel Rim Made From Al-Alloy 2014-T6

    OpenAIRE

    G. Kosec; Kovačič, G.; J. Hodolič; Kosec, B.

    2010-01-01

    Generally failures of different aircraft components and parts are revealed and examined by the use of non-destructive examination methods. In further detailed explanation and interpretation of failures optical and scanning electron microscopy are used. This paper deals with a problem of a crack on aircraft wheel rim made from aluminium alloy 2014-T6.The crack was observed during regular control by the maintenance unit for non-destructive examination of the Slovenian air carrier Adria Airways....

  7. RIMS International Conference : Mathematical Challenges in a New Phase of Materials Science

    CERN Document Server

    Kotani, Motoko

    2016-01-01

    This volume comprises eight papers delivered at the RIMS International Conference "Mathematical Challenges in a New Phase of Materials Science", Kyoto, August 4–8, 2014. The contributions address subjects in defect dynamics, negatively curved carbon crystal, topological analysis of di-block copolymers, persistence modules, and fracture dynamics. These papers highlight the strong interaction between mathematics and materials science and also reflect the activity of WPI-AIMR at Tohoku University, in which collaborations between mathematicians and experimentalists are actively ongoing.

  8. Case report 391: Postradiation necrosis of bone (femur) with no evidence of tumour

    Energy Technology Data Exchange (ETDEWEB)

    Datz, F.L.; Manaster, B.J.

    1986-10-01

    The case has been presented of a 21-year-old man who had been treated for Ewing tumor of the femur with local radiation and chemotherapy ten years previously. Significant increased uptake on the angiogram, blood pool studies and delayed imaging phases of the radionuclide scan was observed. This activity had increased dramatically from the bone scan obtained four years previously. Plain roentgenograms showed a mixed sclerotic and lytic lesion in the femur compatible with radionecrosis, recurrent Ewing tumor or radiation-induced osteosarcoma. Based on the findings of the bone scan a tumor was diagnosed and the patient underwent open biopsy. However, radiation osteonecrosis only was present; recurrent Ewing tumor or osteosarcoma was not observed. It may thus be stated that radiation can cause significant increase in uptake on serial bone scans even many years following radiation therapy. These features may simulate recurrent tumor or osteosarcoma. Thus, radionuclide bone scans, even many years after irradiation therapy, will not reliably differentiate between radiation-induced osteosarcoma, recurrent tumor or radiation osteonecrosis in patients who have been treated previously with radiation.

  9. Rimmed vacuoles and the added value of SMI-31 staining in diagnosing sporadic inclusion body myositis.

    Science.gov (United States)

    van der Meulen, M F; Hoogendijk, J E; Moons, K G; Veldman, H; Badrising, U A; Wokke, J H

    2001-07-01

    Problems in diagnosing sporadic inclusion body myositis may arise if all clinical features fit a diagnosis of polymyositis, but the muscle biopsy shows some rimmed vacuoles. Recently, immunohistochemistry with an antibody directed against phosphorylated neurofilament (SMI-31) has been advocated as a diagnostic test for sporadic inclusion body myositis. The aims of the present study were to define a quantitative criterion to differentiate sporadic inclusion body myositis from polymyositis based on the detection of rimmed vacuoles in the haematoxylin-eosin staining and to evaluate the additional diagnostic value of the SMI-31 staining. Based on clinical criteria and creatine kinase levels in patients with endomysial infiltrates, 18 patients complied with the diagnosis of sporadic inclusion body myositis, and 17 with the diagnosis of polymyositis. A blinded observer counted the abnormal fibres in haematoxylin-eosin-stained sections and in SMI-31-stained sections. The optimal cut-off in the haematoxylin-eosin test was 0.3% vacuolated fibres. Adding the SMI-31 staining significantly increased the positive predictive value from 87 to 100%, but increased the negative predictive value only to small extent. We conclude that (1) patients with clinical and laboratory features of polymyositis, including response to treatment, may show rimmed vacuoles in their muscle biopsy and that (2) adding the SMI-31 stain can be helpful in differentiating patients who respond to treatment from patients who do not.

  10. Radiolucent rim as a possible diagnostic aid for differentiating jaw lesions

    Energy Technology Data Exchange (ETDEWEB)

    Mortazavi, Hamed; Baharvand, Maryam; Rarahmani, Somayeh; Jafati, Soudeh; Parvaei, Parvin [Oral Medicine, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran (Iran, Islamic Republic of)

    2015-12-15

    In this study, we formulate a new proposal that complements previous classifications in order to assist dental practitioners in performing a differential diagnosis based on patients' radiographs. We used general search engines and specialized databases such as Google Scholar, PubMed, PubMed Central, MedLine Plus, Science Direct, Scopus, and well-recognized textbooks to find relevant studies by using keywords such as 'jaw disease,' 'jaw lesions,' 'radiolucent rim,' 'radiolucent border,' and 'radiolucent halo.' More than 200 articles were found, of which 70 were broadly relevant to the topic. We ultimately included 50 articles that were closely related to the topic of interest. When the relevant data were compiled, the following eight lesions were identified as having a radiolucent rim: periapical cemento-osseous dysplasia, focal cemento-osseous dysplasia, florid cemento-osseous dysplasia, cemento-ossifying fibroma, osteoid osteoma, osteoblastoma, odontoma, and cementoblastoma. We propose a novel subcategory, jaw lesions with a radiolucent rim, which includes eight entities. The implementation of this new category can help improve the diagnoses that dental practitioners make based on patients' radiographs.

  11. Optic nerve gray crescent can confound neuroretinal rim interpretation: review of the literature.

    Science.gov (United States)

    Arora, Sourabh; Rayat, Jaspreet; Damji, Karim F

    2014-06-01

    The optic nerve gray crescent can be of clinical significance if unrecognized during assessment for glaucoma. It has a characteristic appearance of a slate gray area of pigmentation within the disc margins and commonly appears along the inferotemporal or temporal neuroretinal rim areas. This type of disc rim pigmentation can create the impression of neuroretinal rim thinning, and thus lead to the misdiagnosis of glaucoma or "glaucoma suspect" with attendant implications for overtreatment or unnecessary close monitoring of such patients. The gray crescent is more common in African Americans than whites (prevalence rate 27% vs 7%) and is bilateral in at least 58% of cases. It has been reported in association with Kjer optic atrophy type 1. Suggested causes of the gray crescent include an accumulation of melanocytes, or retinal pigment epithelium cells partially located in the optic nerve head region if Bruch's membrane extends internal to the peripapillary scleral ring. Other causes of pigmentation that may resemble gray crescent are conus pigmentosus and variations of peripapillary atrophy. When a gray crescent is present, clinicians should endeavour to identify the true anatomical disc margins via the scleral lip and, if necessary, evaluate the patient further with imaging and visual field studies.

  12. Surface dimming by the 2013 Rim Fire simulated by a sectional aerosol model

    Science.gov (United States)

    Yu, Pengfei; Toon, Owen B.; Bardeen, Charles G.; Bucholtz, Anthony; Rosenlof, Karen H.; Saide, Pablo E.; Da Silva, Arlindo; Ziemba, Luke D.; Thornhill, Kenneth L.; Jimenez, Jose-Luis; Campuzano-Jost, Pedro; Schwarz, Joshua P.; Perring, Anne E.; Froyd, Karl D.; Wagner, N. L.; Mills, Michael J.; Reid, Jeffrey S.

    2016-06-01

    The Rim Fire of 2013, the third largest area burned by fire recorded in California history, is simulated by a climate model coupled with a size-resolved aerosol model. Modeled aerosol mass, number, and particle size distribution are within variability of data obtained from multiple-airborne in situ measurements. Simulations suggest that Rim Fire smoke may block 4-6% of sunlight energy reaching the surface, with a dimming efficiency around 120-150 W m-2 per unit aerosol optical depth in the midvisible at 13:00-15:00 local time. Underestimation of simulated smoke single scattering albedo at midvisible by 0.04 suggests that the model overestimates either the particle size or the absorption due to black carbon. This study shows that exceptional events like the 2013 Rim Fire can be simulated by a climate model with 1° resolution with overall good skill, although that resolution is still not sufficient to resolve the smoke peak near the source region.

  13. Evidence for an Ancient Buried Landscape on the NW Rim of Hellas Basin, Mars

    Science.gov (United States)

    Crown, David A.; Bleamaster, Leslie F., III; Mest, Scott C.; Mustard, John F.; Vincendon, Mathieu

    2010-01-01

    Hellas basin is the largest (2000+ km across) well-preserved impact structure on Mars and its deepest depositional sink [e.g., 1]. The Hellas rim and adjacent highlands are of special interest given the possibility of paleolakes on the basin floor [2-4], recent studies of potential localized fluvial/lacustrine systems [2, 5-17], and evidence for phyllosilicates around and within impact craters north of the basin [18-26]. We are producing a 1:1.5M-scale geologic map of eight MTM quadrangles (-25312, -25307, -25302, -25297, -30312, -30307, -30302, -30297) along Hellas NW rim. The map region (22.5-32.5degS, 45- 65degE) includes a transect across the cratered highlands of Terra Sabaea, the degraded NW rim of Hellas, and basin interior deposits of NW Hellas Planitia. No previous mapping studies have focused on this region, although it has been included in earlier global and regional maps [27-29].

  14. Radiolucent rim as a possible diagnostic aid for differentiating jaw lesions

    Science.gov (United States)

    Mortazavi, Hamed; Rahmani, Somayeh; Jafari, Soudeh; Parvaei, Parvin

    2015-01-01

    In this study, we formulate a new proposal that complements previous classifications in order to assist dental practitioners in performing a differential diagnosis based on patients' radiographs. We used general search engines and specialized databases such as Google Scholar, PubMed, PubMed Central, MedLine Plus, Science Direct, Scopus, and well-recognized textbooks to find relevant studies by using keywords such as "jaw disease," "jaw lesions," "radiolucent rim," "radiolucent border," and "radiolucent halo." More than 200 articles were found, of which 70 were broadly relevant to the topic. We ultimately included 50 articles that were closely related to the topic of interest. When the relevant data were compiled, the following eight lesions were identified as having a radiolucent rim: periapical cemento-osseous dysplasia, focal cemento-osseous dysplasia, florid cemento-osseous dysplasia, cemento-ossifying fibroma, osteoid osteoma, osteoblastoma, odontoma, and cementoblastoma. We propose a novel subcategory, jaw lesions with a radiolucent rim, which includes eight entities. The implementation of this new category can help improve the diagnoses that dental practitioners make based on patients' radiographs. PMID:26730374

  15. Energy indicators series: analyzing the energy-related evidence of economic transition in the Pacific Rim

    International Nuclear Information System (INIS)

    In recent years, much attention has been focused upon the Asian Pacific countries as constituting an economic 'miracle' over the last two decades. Economic growth in the Pacific Rim has been higher than in any other area of the world. The rapid industrialization process and its impact on the economies of these countries, at both macro and micro levels, are discussed widely in the economic literature. Of particular interest are the fundamental structural changes these countries have experienced in their transition to industrialized economies. This instalment of the annual 'Energy indicators' series concentrates on Pacific Rim countries, namely Hong Kong, the Philippines, Singapore, South Korea, Taiwan and Thailand. Similar to other experiences, rapid economic growth in these countries has been accompanied by 'spectacular' growth in demand for energy. Therefore, this year's paper not only underlines certain trends in these six energy markets but also attempts to test the phenomenon 'threshold country', i.e., shifting from the developing to the industrialized world by using common indicators and methodologies. The analysis starts with a comparison of energy intensities. Section 2 provides an overview of the socio-economic and energy indicators of the Pacific Rim countries. Section 3 introduces a standard econometric model on the most dynamic consuming sector, namely transport. Section 4 presents the projections of consumption in this sector and discusses policy issues. Some concluding remarks in Section 6 complete the paper. (author)

  16. Chondroblastoma arising in the triradiate cartilage. Report of two cases with review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Matsuno, Takeo; Hasegawa, Isao; Masuda, Takeshi

    1987-04-01

    Chondroblastoma is a relatively rare benign bone tumor of cartilage origin. Roentgenologically it presents usually as a region of lytic destruction of bone with a thin sclerotic rim in the epiphysis of long tubular bone. Less than 9% occur in the pelvic bones but show a tendency to arise from the triradiate cartilage. We present two cases of chondroblastoma originating in the triradiate cartilage, each showing extensive lytic bony destruction and an intrapelvic soft tissue mass. A review of the literature suggests that chondroblastoma of the triradiate cartilage shows an aggressive radiological appearance.

  17. Bone graft revascularization strategies

    NARCIS (Netherlands)

    W.F. Willems

    2014-01-01

    Reconstruction of avascular necrotic bone by pedicled bone grafting is a well-known treatment with little basic research supporting its application. A new canine model was used to simulate carpal bone avascular necrosis. Pedicled bone grafting proved to increase bone remodeling and bone blood flow,

  18. 75 FR 14243 - Pacific Rim Railway Company, Inc.-Acquisition and Operation Exemption-City of Keokuk, IA

    Science.gov (United States)

    2010-03-24

    ... of Keokuk, IA Pacific Rim Railway Company, Inc. (PRIM), a noncarrier, has filed a verified notice of exemption under 49 CFR 1150.31 to acquire from the City of Keokuk, IA and to operate approximately...

  19. Nat'l_Register, ContributingResources, The Rim Trail at Pipe Spring National Monument, Arizona (pisp_qrytrail)

    Data.gov (United States)

    National Park Service, Department of the Interior — This is an Arc/Info coverage consisting of 4 arcs representing the portion of The Rim Trail at Pipe Spring National Monument, Arizona that occurs within the...

  20. Feasibility and Safety of Transthoracic Echocardiography-Guided Transcatheter Closure of Atrial Septal Defects with Deficient Superior-Anterior Rims

    OpenAIRE

    Gui-Shuang Li; Hai-De Li; Jie Yang; Wen-Quan Zhang; Zong-Shen Hou; Qing-Chen Li; Yun Zhang

    2012-01-01

    Although previous studies showed that transthoracic echocardiography (TTE) can be used to guide transcatheter closure of atrial septal defect (ASD), whether TTE can be used to guide transcatheter closure of secundum ASD with a deficient superior-anterior rim is unknown and this critical issue was addressed in the present study. A total of 280 patients with secundum ASD who underwent transcatheter ASD closure were recruited and divided into groups A and B depending on ASD superior-anterior rim...

  1. A Method to Prepare a Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) Graft Using Donor Corneas With Narrow Scleral Rims

    OpenAIRE

    Lin, Tzu-Yu; Hwang, Yih-Shiou; Ma, David Hui-Kang

    2015-01-01

    Abstract Donor corneas with narrow scleral rims are often disqualified for Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK), mainly because of fluid leak and low pressure when they are mounted onto an artificial anterior chamber (AAC). This report describes a novel method to tight-lock a donor cornea with a narrow scleral rim so that microkeratome cutting is possible, allowing a DSAEK procedure to be completed. A 50-year-old male suffering from Epstein–Barr virus (EBV) endothel...

  2. Fission gas release behavior in high burnup UO{sub 2} fuels with developed rim-structure

    Energy Technology Data Exchange (ETDEWEB)

    Une, Katsumi [Global Nuclear Fuel-Japan Co. Led., Oarai, Ibaraki (Japan); Kashibe, Shinji [Nippon Nuclear Fuel Development Co. Ltd., Oarai, Ibaraki (Japan); Hayashi, Kimio [Japan Atomic Energy Research Inst., Tokyo (Japan)

    2002-11-01

    The effect of rim structure formation and external restraint pressure on fission gas release at transient conditions has been examined by using an out-of-pile high pressure heating technique for high burnup UO{sub 2} fuels (60, 74 and 90 GWd/t), which had been irradiated in test reactors. The latter two fuels bore a developed rim structure. The maximum heating temperature was 1500 degC, and the external pressures were independently controlled in the range of 10-150 MPa. The present high burnup fuel data were compared with those of previously studied BWR fuels of 37 and 54 GWd/t with almost no rim structure. The fission gas release and bubble swelling due to the growth of grain boundary bubbles and coarsened rim bubbles were effectively suppressed by the strong restraint pressure of 150 MPa for all the fuels; however the fission gas release remarkably increased for the two high burnup fuels with the developed rim structure, even at the strong restraint conditions. From the stepwise de-pressurization tests at an isothermal condition of 1500degC, the critical external pressure, below which a large burst release due to the rapid growth and interlinkage of the bubbles abruptly begins, was increased from a 40-60 MPa level for the middle burnup fuels to a high level of 120-140 MPa for the rim-structured high burnup fuels. The high potential for transient fission gas release and bubble swelling in the rim-structured fuels was attributed to highly over-pressurized fission gases in the rim bubbles. (author)

  3. Dual-time-point FDG-PET/CT Imaging of Temporal Bone Chondroblastoma: A Report of Two Cases.

    Science.gov (United States)

    Toriihara, Akira; Tsunoda, Atsunobu; Takemoto, Akira; Kubota, Kazunori; Machida, Youichi; Tateishi, Ukihide

    2015-01-01

    Temporal bone chondroblastoma is an extremely rare benign bone tumor. We encountered two cases showing similar imaging findings on computed tomography (CT), magnetic resonance imaging (MRI), and dual-time-point (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/CT. In both cases, CT images revealed temporal bone defects and sclerotic changes around the tumor. Most parts of the tumor showed low signal intensity on T2-weighted MRI images and non-uniform enhancement on gadolinium contrast-enhanced T1-weighted images. No increase in signal intensity was noted in diffusion-weighted images. Dual-time-point PET/CT showed markedly elevated (18)F-FDG uptake, which increased from the early to delayed phase. Nevertheless, immunohistochemical analysis of the resected tumor tissue revealed weak expression of glucose transporter-1 and hexokinase II in both tumors. Temporal bone tumors, showing markedly elevated (18)F-FDG uptake, which increases from the early to delayed phase on PET/CT images, may be diagnosed as malignant bone tumors. Therefore, the differential diagnosis should include chondroblastoma in combination with its characteristic findings on CT and MRI. PMID:27408892

  4. Dual-time-point FDG-PET/CT Imaging of Temporal Bone Chondroblastoma: A Report of Two Cases

    Directory of Open Access Journals (Sweden)

    Akira Toriihara

    2015-07-01

    Full Text Available Temporal bone chondroblastoma is an extremely rare benign bone tumor. We encountered two cases showing similar imaging findings on computed tomography (CT, magnetic resonance imaging (MRI, and dual-time-point 18F-fluorodeoxyglucose (18F-FDG positron emission tomography (PET/CT. In both cases, CT images revealed temporal bone defects and sclerotic changes around the tumor. Most parts of the tumor showed low signal intensity on T2- weighted MRI images and non-uniform enhancement on gadolinium contrast-enhanced T1-weighted images. No increase in signal intensity was noted in diffusion-weighted images. Dual-time-point PET/CT showed markedly elevated 18F-FDG uptake, which increased from the early to delayed phase. Nevertheless, immunohistochemical analysis of the resected tumor tissue revealed weak expression of glucose transporter-1 and hexokinase II in both tumors. Temporal bone tumors, showing markedly elevated 18F-FDG uptake, which increases from the early to delayed phase on PET/CT images, may be diagnosed as malignant bone tumors. Therefore, the differential diagnosis should include chondroblastoma in combination with its characteristic findings on CT and MRI.

  5. Dual-time-point FDG-PET/CT Imaging of Temporal Bone Chondroblastoma: A Report of Two Cases.

    Science.gov (United States)

    Toriihara, Akira; Tsunoda, Atsunobu; Takemoto, Akira; Kubota, Kazunori; Machida, Youichi; Tateishi, Ukihide

    2015-01-01

    Temporal bone chondroblastoma is an extremely rare benign bone tumor. We encountered two cases showing similar imaging findings on computed tomography (CT), magnetic resonance imaging (MRI), and dual-time-point (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/CT. In both cases, CT images revealed temporal bone defects and sclerotic changes around the tumor. Most parts of the tumor showed low signal intensity on T2-weighted MRI images and non-uniform enhancement on gadolinium contrast-enhanced T1-weighted images. No increase in signal intensity was noted in diffusion-weighted images. Dual-time-point PET/CT showed markedly elevated (18)F-FDG uptake, which increased from the early to delayed phase. Nevertheless, immunohistochemical analysis of the resected tumor tissue revealed weak expression of glucose transporter-1 and hexokinase II in both tumors. Temporal bone tumors, showing markedly elevated (18)F-FDG uptake, which increases from the early to delayed phase on PET/CT images, may be diagnosed as malignant bone tumors. Therefore, the differential diagnosis should include chondroblastoma in combination with its characteristic findings on CT and MRI.

  6. The Enigmatic Bench Unit of Endeavour Crater Rim in Meridiani Planum, Mars

    Science.gov (United States)

    Ruff, S. W.

    2013-12-01

    For the first 2680 sols of its mission, the Mars Exploration Rover Opportunity traversed across essentially the same rocks: sulfur-rich sandstones known as the Burns formation. On August 8, 2011 Opportunity completed a ~21 km traverse from Victoria crater to the rim of the ~22 km diameter Endeavour crater where it crossed a slightly raised smooth bench unit that surrounds an interior core of higher standing and more rugged terrain on a rim segment named Cape York. As recognized by its distinctive morphologic character evident in orbital images, the inward sloping bench feature is found associated with portions of other segments of the discontinuous raised rim of Endeavour crater. Viewed by Opportunity, it appears as platy, fractured, relatively light-toned outcrop that is fine-grained, lacks hematite concretions and in places hosts veins of Ca- and S-rich composition, likely due to precipitation of gypsum in fractures that cut the bench unit (1). The bench outcrop target named Grasberg included a grind using the Rock Abrasion Tool (RAT) to obtain a cleaner surface for the Alpha Particle X-ray Spectrometer chemistry measurement compared with the initially investigated target named Deadwood. In addition to its greater strength than Burns formation as determined by the RAT grind operation, Grasberg and other examples of the bench unit have lower S, higher Cl and other elemental characteristics that depart from typical Burns formation. Thus the 'Grasberg unit' clearly represents a distinct rock type compared to the Meridiani plains. A second unit makes up the exposed core of the Cape York rim segment. Known as Shoemaker formation, it is composed of breccias that are recognized as a suevite deposit produced from the Endeavour impact event (1). The Shoemaker formation appears to be onlapped by the Grasberg unit with Burns formation onlapping it (1). However, a well-exposed section observed in a wedge-shaped fracture known as Whim Creek on the northeast portion of the

  7. Minocycline-associated rimmed vacuolar myopathy in a patient with rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    Bokuda Kota

    2012-11-01

    Full Text Available Abstract Background The autophagic vacuolar myopathies (AVM are a group of inherited myopathies defined by the presence of autophagic vacuoles in pathological muscle specimens. AVM can be categorized into three groups: acid maltase deficiency, myopathies characterized by autophagic vacuoles with unique sarcolemmal features, and rimmed vacuolar myopathies (RVM. While the pathogeneses of these conditions are still being elucidated, some drugs (e.g., chloroquine, its analog, hydroxychloroquine, and colchicine can also cause AVM. Minocycline is a disease-modifying anti-rheumatic drug that may be used in the treatment of rheumatoid arthritis (RA. Here, we describe the first case of minocycline-associated AVM with rimmed vacuole formation. Case presentation A 75-year-old woman suffering from RA has been continuously treated with minocycline (200 mg/day for the past 7 years. During this time, she developed a myopathy that predominantly affected her lower limbs. Histological studies of biopsied muscle revealed scattered atrophic myofibers with rimmed vacuoles that contained pigment granules. Histochemical staining revealed that the pigment comprised both iron and melanin, which is consistent with type II minocycline-induced cutaneous pigmentation. Under electron microscopy, autophagic vacuoles were consistently observed in association with numerous collections of pigment granules. Conclusions This is the first report of minocycline-induced pigmentation in skeletal muscle. The strong association between autophagic vacuoles and the accumulation of minocycline-induced pigments suggest that long-term minocycline treatment induced pigment accumulation, leading to elevation of autophagic activity and RVM. It might also be possible that minocycline directly activated autophagy, as the observed pigments are known to form complexes containing minocycline and/or its metabolites. As long-term minocycline treatment is expected to be used more widely in the future

  8. Study of iocalization rim void%定位孔缘破孔的研究

    Institute of Scientific and Technical Information of China (English)

    林秀鑫; 薛敏芬

    2012-01-01

      主要介绍孔缘破孔(在碱性蚀刻流程中发生的干膜流胶入孔致孔中开路)的影响因素。对定位孔缘破孔的形成机理进行分析及试验模拟,得出定位孔缘破孔的原因为:特殊结构特征板件在贴膜后板件板面局部温度较高,在没有散热完全情况下被收板放置在一起,导致定位区域干膜继续流胶入孔。通过提高贴膜后板件散热效果,最终杜绝定位孔缘破孔的产生。%  This paper mainly introduces the factors of rim void, which is the resist flows into the hole and causes hole-opening in alkaline etching process. The rim void occurs in the same location, which was analyzed through theory and simulated by experiments, and the reason was archived. The temperature of local area with special structural characteristics boards is higher than others’, if the heat dissipation was poor after resist lamination, it will cause the resist flows farer into the hole in this location area. By improving the effect of heat dissipation after resist lamination, the location of the rim void will be eliminated finally.

  9. Technical Efficiency and Port Competition: Revisiting the Bohai Economic Rim, China

    Directory of Open Access Journals (Sweden)

    Grace Wang

    2012-12-01

    Full Text Available The Bohai Economic Rim plays an important role in supporting China’s economic growth. For this research, we selected nine main ports in the region to study whether intra-port competition or corporatization would improve efficiency. Using a panel fixed effect model and stochastic frontier model, we found that the technical efficiency of selected ports is significantly influenced by the time of the initial public offering than by regional competition. The results are supportive and encouraging for policy makers to move toward the decentralized port governance in China.

  10. “Walk the Rim, Feel the Bone” Technique in Superior Sulcus Filling

    Science.gov (United States)

    Yong, Kai-Ling

    2015-01-01

    Summary: Superior sulcus filler injection is a nonsurgical method to rejuvenate the upper face. Blindness and stroke are devastating complications of facial filler injection. This study describes an injection technique that minimizes the risk of blindness and includes a case study demonstrating the cosmetic benefits of this procedure. To avoid retrograde injection of filler embolus into the ophthalmic artery, we advocate a “‘walk the rim, feel the bone” approach. Small boluses of hyaluronic acid filler are given in preperiosteal plane, avoiding the superior orbital foramen. PMID:26894017

  11. "To Drink from Places": Uncovering a Rich Way of Life Near the Grand Canyon's North Rim

    OpenAIRE

    Rich, Melinda Snow

    2010-01-01

    The chapters of this thesis focus on the history and stories of the people who built and traveled down the highways--Highway 89A, Highway 89, and Highway 67--that branch out from the junction in front of Jacob Lake Inn, the Bowman/Rich family's 87-year-old lodge. The family's role in building roads, supporting and encouraging the growing tourist industry in Kanab and the North Rim of the Grand Canyon, and the converging effects of these choices have created the unique family culture and contr...

  12. Formation of upper rim acylated calix[4]arenes using a sacrifici al zinc anode

    OpenAIRE

    Louati, Alain; Vataj, Rame; Gabelica, Valérie; Lejeune, Manuel; MATT, DOMINIQUE

    2005-01-01

    A straightforward electrosynthetic method is described, which allows upper rim acylation of non-p-halogenated calix[4]-arenes. For example, a solution of tetrapropoxycalix[4]arene 4 was electrolysed in the presence of ZnBr2, in an undivided cell fitted with a sacrificial zinc anode using pure acetonitrile as solvent, yielding an organozinc species, which was then treated with acetyl chloride in the presence of a palladium catalyst to afford 5,11-diacety1-25,26,27,28-tetrapropoxycalix[4]arene ...

  13. Arthroscopic Fixation of Glenoid Rim Fractures After Reduction by Labral Repair.

    Science.gov (United States)

    Voleti, Pramod B; Camp, Christopher L; Sinatro, Alec L; Dines, Joshua S

    2016-04-01

    Surgical fixation of displaced, intra-articular glenoid fractures represents a clinical challenge. These fractures have traditionally been treated through open approaches to the glenohumeral joint; however, the morbidity associated with open surgery may be reduced with arthroscopic techniques. Previously described arthroscopic methods commonly use clamps and/or Kirschner wires to obtain and maintain provisional fixation. We describe our technique for minimally invasive, arthroscopic fixation of glenoid rim fractures using labral repair as an indirect reduction maneuver, followed by final fixation with an extra-articular screw. This method is safe, efficient, and reliable, and it can be used to approach a variety of intra-articular glenoid fractures. PMID:27462537

  14. Localized and Areally Extensive Alterations in Marathon Valley, Endeavour Crater Rim, Mars

    Science.gov (United States)

    Mittlefehldt, David W.; Gellert, Ralf; Van Bommel, Scott; Arvidson, Raymond E.; Clark, Benton C.; Cohen, Barbara A.; Farrand, William H.; Ming, Douglas W.; Schroeder, Christian; Yen, Albert S.; Jolliff, Bradley L.

    2016-01-01

    Mars Exploration Rover Opportunity is exploring the rim of 22 km diameter, Noachian-aged Endeavour crater. Marathon Valley cuts through the central region of the western rim providing a window into the local lower rim stratigraphic record. Spectra from the Compact Reconnaissance Imaging Spectrometer for Mars show evidence for the occurrence of Fe-Mg smectite in this valley, indicating areally extensive and distinct lithologic units and/or styles of aqueous alteration. The Alpha Particle X-ray Spectrometer has determined the compositions of 59 outcrop targets on untreated, brushed and abraded surfaces. Rocks in the Marathon Valley region are soft breccias composed of mm- to cm-sized darker clasts set in a lighter-toned, finegrained matrix. They are basaltic in non-volatile-element composition and compositionally similar to breccias investigated elsewhere on the rim. Alteration styles recorded in the rocks include: (1) Enrichments in Si, Al, Ti and Cr in more reddish-colored rock, consistent with leaching of more soluble cations and/or precipitation of Si +/- Al, Ti, Cr from fluids. Coprecipitation of Ge-rich phases with Si occurred in the western area only; high water:rock is indicated. Pancam multispectral observations indicate higher nanophase ferric oxide contents, but the rocks have lower Fe contents. The highly localized nature of the red zones indicate they cannot be the source of the widespread smectite signature observed from orbit. (2) Outcrops separated by approximately 65 m show common compositional changes between brushed and abraded (approximately 1 mm deep) targets: increases in S and Mg; decreases in Al, Cl and Ca. These changes are likely due to relatively recent, surface-related alteration of valley rocks and formation of surface coatings under low water:rock. (3) One target, from the center of a region of strong CRISM smectite signature, shows modest differences in composition (higher Si, K; lower Mn) compared to most Marathon Valley rocks, while

  15. Design optimization of a slotless PM brushless motor with spiral wound laminations for rim driven thrusters

    OpenAIRE

    Sharkh, S.M.; Lai, S. H.

    2009-01-01

    This paper discusses the analysis and design of a very thin slotless PM brushless motor whose stator laminations are manufactured from a single strip of steel that is edge wound into a spiral (like a “Slinky”) and then fitted over the windings that are preformed on the outside surface of a non-conducting former. Analytical and finite element analysis (FEA) are used to determine the constrained optimum dimensions of a motor used to drive a rim driven thruster in which the motor rotor is fitted...

  16. Hand-rim Forces and Gross Mechanical Efficiency at Various Frequencies of Wheelchair Propulsion

    OpenAIRE

    Lenton, J. P.; Van der Woude, L.H.V.; Fowler, N. E.; G. Nicholson; Tolfrey, K.; Goosey-Tolfrey, V. L.

    2013-01-01

    To determine the effects of push frequency changes on force application, fraction of effective force (FEF) and gross efficiency (GE) during hand-rim propulsion. 8 male able-bodied participants performed five 4-min sub-maximal exercise bouts at 1.8 m.s(-1); the freely chosen frequency (FCF), followed by 4 counter-balanced trials at 60, 80, 120 and 140 % FCF. Kinetic data was obtained using a SMART(Wheel), measuring forces and moments. The GE was determined as the ratio of external work done an...

  17. Pyogenic osteomyelitis of long bone: MR findings

    International Nuclear Information System (INIS)

    To evaluate the usefulness of MR in the osteomyelitis, we reviewed MR examinations of 14 patients with pyogenic osteomyelitis of the long bone. All 14 patients were confirmed to have osteomyelitis either surgically (13/14) or by aspiration (1/14). MRI was performed with 0.5 T (n=8) or 2.0 T (n=6) SE technique, and Gd-DTPA enhanced T1WI was obtained in 10 examinations. Anatomic location of lesions were femur (8/14), tibia (5/14) , and fibula (1/14). The marrow cavity and soft tissue were involved in 13/14, 12/14 respectively. The signals of both intraosseous and extraosseous infected area were iso to low signal intensity to muscles on T1WI and high signal intensity on PDWI and T2WI. Rim or diffuse enhancement of the marrow cavity and soft tissue were seen in all (10/10) case. Sequestra, periosteal reaction, and cortical defect were found in 12/14, 10/14, 9/14. MR provided more accurate and detailed anatomic information including extent of disease and possible activity than bone scintigraphy, CT, or conventional radiography. We conclude that MR might be the choice of modality in the diagnosis of osteomyelitis of the long bone

  18. Osteoclasts prefer aged bone

    DEFF Research Database (Denmark)

    Henriksen, K; Leeming, Diana Julie; Byrjalsen, I;

    2007-01-01

    We investigated whether the age of the bones endogenously exerts control over the bone resorption ability of the osteoclasts, and found that osteoclasts preferentially develop and resorb bone on aged bone. These findings indicate that the bone matrix itself plays a role in targeted remodeling...

  19. Deflated rims along the Xiangshui River on the Xiliaohe Plain, Northeast China: A case of active fluvial-aeolian interactions

    Science.gov (United States)

    Han, Guang; Zhang, Guifang; You, Li; Wang, Yong; Yang, Lin; Yang, Ji; Zhou, Liang; Yuan, Minghuan; Zou, Xueyong; Cheng, Hong

    2016-03-01

    Riverine source-bordering sand dunes, as a result of active fluvial-aeolian interactions, are a pronounced feature on the semiarid Xiliaohe Plain, Northeast China. By means of satellite imagery analysis, and both field survey and observation, this paper presents a new type of riverine source-bordering sand dunes - deflated rims, on the downwind margins of the Xiangshui River. They largely result from the deflation of escarpments on the downwind side of valley by local prevailing winds of NW direction, not from the reworking of point bars on floodplain by wind. In general, a rim is primarily composed of three distinct zones: 1) the upwind frontal escarpment zone with variable plan-form shape, gradient and relief, which is formed by either active lateral erosion by river or significant erosion by wind and transient slope runoff; 2) the deflation zone with gentle slopes of 8-18° and small-scale aeolian bedforms, i.e. ripples of fine sand, ridges of coarse sand; and 3) the downwind dynamic deposition zone with distinctive bedforms with variable superficial texture and slip faces. The sand mass on rims derives overwhelmingly from underlying loose late Quaternary sediments, is sufficient and sustainable by successive retreats of the escarpment, and is gradually transported downwind by pulse motions of bedforms, coupled with high wind events. Essentially, deflated rims are a starting point and the incipient phase of mature riverine dunefields. The superimposed bedforms on rims are fundamentally governed by windflow dynamics, sand sediments and antecedent bedform, exhibiting in turn the manner and intensity of rim development. Consequently, the upwind river valley and downwind deflated rim can jointly stimulate marked wave-like motion of both windflow and aeolian bedforms at different scales, especially when high wind events occur. This study sheds some light on the understanding of the origin and development of riverine source-bordering dunefields, and offers new

  20. Structural Effects on the Langmuir Monolayers of Calix[4]arene Induced by Lower Rim Aromatic Substitution

    Institute of Scientific and Technical Information of China (English)

    HE Wei-Jiang; QIU Lin; LI Jun-Bai; ZHANG Yu; GUO Zi-Jian; ZHU Long-Gen

    2006-01-01

    The Langmuir monolayer properties of lower rim aromatically substituted calix[4]arenes, 5,11,17,23-tetra-tertbutyl-25,27-bis(2-naphth-1'-ylacetylaminoethoxy)-26,28-dihydroxylcalix[4]arene (BNAEC), 5,11,17,23-tetra-tertbutyl-25,27-bis(2-benzoylamino ethoxy)-26,28-dihydroxylcalix[4]arene (BBAEC) and 5,11,17,23-tetra-tert-butyl-25,27-bis(2-cinnamoylaminoethoxy)-26,28-dihydroxylcalix[4]arene (BCAEC), have been studied. Film balance measurements and Brewster angle microscopy (BAM) observation demonstrate that all the compounds can form Langmuir monolayers with different molecular limiting areas. BNAEC or BBAEC monolayer is able to form condensed domains during compression, while BCAEC monolayer can never form condensed domain. BNAEC monolayer is more readily to form condensed domain than BBAEC monolayer. Moreover, BNAEC monolayer can form the total condensed phase during compression even when T=28 ℃, while BBAEC monolayer can not when T> 10 ℃. The results imply that different lower rim aromatic substitutions affect essentially the intermolecular interaction and molecular packing in the monolayer at air/water interface.

  1. Nonthermal emission properties of the northwestern rim of supernova remnant RX J0852-4622

    CERN Document Server

    Kishishita, Tetsuichi; Uchiyama, Yasunobu

    2013-01-01

    The supernova remnant (SNR) RX J0852-4622 (Vela Jr., G266.6-1.2) is one of the most important SNRs for investigating the acceleration of multi-TeV particles and the origin of Galactic cosmic rays because of its strong synchrotron X-ray and TeV gamma-ray emission, which show a shell-like morphology similar to each other. Using the XMM-Newton archival data consisting of multiple pointing observations of the northwestern rim of the remnant, we investigate the spatial properties of the nonthermal X-ray emission as a function of distance from an outer shock wave. All X-ray spectra are well reproduced by an absorbed power-law model above 2 keV. It is found that the spectra show gradual softening from a photon index 2.56 in the rim region to 2.96 in the interior region. We show that this radial profile can be interpreted as a gradual decrease of the cutoff energy of the electron spectrum due to synchrotron cooling. By using a simple spectral evolution model that includes continuous synchrotron losses, the spectral s...

  2. Rim intratorácico ectópico Thoracic ectopic kidney

    Directory of Open Access Journals (Sweden)

    Claudinei Leôncio Beraldo

    2005-04-01

    Full Text Available O rim ectópico intratorácico é uma anomalia rara. De todas as ectopias renais é a mais rara (p = 0,005%. Relata-se um caso de ectopia renal intratorácica em um homem negro de 83 anos, que procurou atendimento médico com quadro clínico compatível com enfisema pulmonar. Foi solicitado radiograma de tórax, que evidenciou uma massa, diagnosticada por tomografia computadorizada como ectopia renal. A maioria dos casos de rim torácico aparece como uma tumoração intratorácica encontrada em radiogramas de tórax solicitados por qualquer outra razão alheia à suspeita dessa anomalia, e não necessita de tratamento específico.Thoracic ectopic kidney is a rare anomaly, the rarest of all renal ectopia types (p = 0.005%. Herein, we describe a case of thoracic ectopic kidney in an 83-year-old black man who, upon seeking medical attention, presented a clinical profile consistent with pulmonary emphysema. A chest X-ray was ordered, and the results showed evidence of a mass, which was then diagnosed (through computed tomography as renal ectopia. The majority of thoracic ectopic kidney cases present as an intrathoracic tumor seen on chest X-rays ordered for reasons other than suspicion of this anomaly and do not require special treatment.

  3. Sar1 localizes at the rims of COPII-coated membranes in vivo

    Science.gov (United States)

    Suda, Yasuyuki; Nakano, Akihiko

    2016-01-01

    ABSTRACT The Sar1 GTPase controls coat assembly on coat protein complex II (COPII)-coated vesicles, which mediate protein transport from the endoplasmic reticulum (ER) to the Golgi. The GTP-bound form of Sar1, activated by the ER-localized guanine nucleotide exchange factor (GEF) Sec12, associates with the ER membrane. GTP hydrolysis by Sar1, stimulated by the COPII-vesicle-localized GTPase-activating protein (GAP) Sec23, in turn causes Sar1 to dissociate from the membrane. Thus, Sar1 is cycled between active and inactive states, and on and off vesicle membranes, but its precise spatiotemporal regulation remains unknown. Here, we examined Sar1 localization on COPII-coated membranes in living Saccharomyces cerevisiae cells. Two-dimensional (2D) observation demonstrated that Sar1 showed modest accumulation around the ER exit sites (ERES) in a manner that was dependent on Sec16 function. Detailed three-dimensional (3D) observation further demonstrated that Sar1 localized at the rims of the COPII-coated membranes, but was excluded from the rest of the COPII membranes. Additionally, a GTP-locked form of Sar1 induced abnormally enlarged COPII-coated structures and covered the entirety of these structures. These results suggested that the reversible membrane association of Sar1 GTPase leads to its localization being restricted to the rims of COPII-coated membranes in vivo. PMID:27432890

  4. The Refined Shock Velocity of the X-Ray Filaments in the RCW 86 Northeast Rim

    CERN Document Server

    Yamaguchi, Hiroya; Castro, Daniel; Williams, Brian J; Lopez, Laura A; Slane, Patrick O; Smith, Randall K; Petre, Robert

    2016-01-01

    A precise measurement of shock velocities is crucial for constraining the mechanism and efficiency of cosmic-ray (CR) acceleration at supernova remnant (SNR) shock fronts. The northeastern rim of the SNR RCW 86 is thought to be a particularly efficient CR acceleration site, owing to the recent result in which an extremely high shock velocity of ~6000 km/s was claimed (Helder et al. 2009). Here we revisit the same SNR rim with the Chandra X-ray Observatory, 11 years after the first observation. This longer baseline than previously available allows us to determine a more accurate proper motion of the nonthermal X-ray filament, revealing a much lower velocity of 3000 \\pm 340 km/s (and even slower at a brighter region). Although the value has dropped to a half of that from the previous X-ray measurement, it is still higher than the mean velocity of the H-alpha filaments in this region (~1200 km/s). This discrepancy implies that the filaments bright in nonthermal X-rays and H-alpha emission trace different velocit...

  5. SURGICAL SITE INFECTIONS: A STUDY OF INCIDENCE, RISK FACTORS & ANTIMICROBIAL SENSITIVITY AT RIMS, KADAPA, A. P.

    Directory of Open Access Journals (Sweden)

    Giridhar

    2015-08-01

    Full Text Available S urgical site infection is the most common complication following surgical procedures. The aim of the study is to determine the incidence, associated risk factors and antimicrobial sensitivity pattern at RIMS, KADAPA. MATERIALS AND METHODS: This is a prospective study carried at surgical wards of RIMS KADAPA from Jan. 2015 to June 2015. All the patients were followed for 30 days for development of surgical site infection. Infected cases were identified u sing CDC, criteria. All the data are expressed in percentage. RESULTS : The overall prevalence of surgical site infection is 19%. The incidence was more common in age group above 40 years. The risk factors associated with SSI are long stay in hospital (14% , abdominal surgeries, long duration of surgery, and diabetes. The most common organism isolated is Staphylococcus aureus (30%. CONCLUSION: Surgical site infection is most common following surgery. Significant determinants are long stay in the ward, abdomi nal surgeries, emergency surgeries and diabetes. Effective infection control measures and good regular surveillance will improve the SSI rate to an acceptable level.

  6. Characterization/Selection of a Continuous Wave Laser for RIMS Analysis in Nuclear Forensics

    Science.gov (United States)

    Lau, Sunny; Alves, F.; Karunasiri, G.; Smith, C.; Isselhardt, B.

    2015-03-01

    The effort to implement the technology of resonance ionization mass spectroscopy (RIMS) to problems of nuclear forensics involves the use of multiple lasers to selectively ionize the elements of concern. While current systems incorporate pulsed lasers, we present the results of a feasibility study to determine alternative (Continuous Wave) laser technologies to be employed for analysis of the actinides and fission products of debris from a nuclear detonation. RIMS has the potential to provide rapid isotope ratio quantification of the actinides and important fission products for post detonation nuclear forensics. The current approach to ionize uranium and plutonium uses three Ti-Sapphire pulsed lasers capable of a fundamental wavelength range of 700-1000 nm. In this work, we describe the use of a COTS CW laser to replace one of the pulsed lasers used for the second resonance excitation step of plutonium near 847.282 nm. We characterize the critical laser parameters necessary to achieve high precision isotope ratio measurements including the stability over time of the mean wavelength, bandwidth and spectral mode purity. This far narrower bandwidth laser provides a simpler setup, more robust hardware (greater mobility), and more efficient use of laser irradiance.

  7. A bright-rimmed cloud sculpted by the H ii region Sh2-48

    CERN Document Server

    Ortega, M E; Giacani, E; Rubio, M; Dubner, G

    2013-01-01

    To characterize a bright-rimmed cloud embedded in the HII region Sh2-48 searching for evidence of triggered star formation. We carried out observations towards a region of 2'x2' centered at RA=18h 22m 11.39s, dec.=-14deg 35m 24.81s (J2000) using the Atacama Submillimeter Telescope Experiment (ASTE; Chile) in the 12CO J=3-2,13CO J=3-2, HCO+ J=4-3, and CS J=7-6 lines with an angular resolution of about 22". We also present radio continuum observations at 5 GHz carried out with the Jansky Very Large Array (JVLA; EEUU) interferometer with a synthetized beam of 7"x5". The analysis of our molecular observations reveals the presence of a relatively dense clump with n(H_2)~3x10^3 cm^-3, located in projection onto the interior of the HII region Sh2-48. The emission distribution of the four observed molecular transitions has, at VLSR~38 kms^-1, morphological anti-correlation with the bright-rimmed cloud as seen in the optical emission. From the new radio continuum observations we identify a thin layer of ionized gas lo...

  8. Alumina+Silica+/-Germanium Alteration in Smectite-Bearing Marathon Valley, Endeavour Crater Rim, Mars

    Science.gov (United States)

    Mittlefehldt, D. W.; Gellert, R.; Van Bommel, S.; Arvidson, R. E.; Clark, B. C.; Ming, D. W.; Schroeder, C.; Yen, A. S.; Fox, V. K.; Farrand, W. H.; Jolliff, B. L.

    2016-01-01

    Mars Exploration Rover Opportunity has been exploring Mars for 12+ years, and is presently investigating the geology of a western rim segment of 22 kilometers diameter, Noachian- aged Endeavour crater. The Alpha Particle X-ray Spectrometer has determined the compositions of a pre-impact lithology, the Matijevic fm., and polymict impact breccias ejected from the crater, the Shoemaker fm. Opportunity is now investigating a region named Marathon Valley that cuts southwest-northeast through the central portion of the rim segment and provides a window into the lower stratigraphic record. (Geographic names used here are informal.) At the head of Marathon Valley, referred to here as Upper Marathon Valley, is a shallow, ovoid depression approximately 25×35 millimeters in size, named Spirit of Saint Louis. Layering inside Spirit of Saint Louis appears continuous with the Upper Marathon Valley rocks outside, indicating they are coeval. Spirit of Saint Louis is partly bounded by approximately 10-20 centimeters wide zone containing reddish altered rocks (red zone). Red zones also form prominent curvilinear features in Marathon Valley. Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) spectra provide evidence for a really extensive Fe-Mg smectite in the Marathon Valley region, indicating distinct styles of aqueous alteration. The CRISM detections of smectites are based on metal-OH absorptions at approximately 2.3 and 2.4 micron that are at least two times the background noise level.

  9. Bone marrow aspiration

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/003658.htm Bone marrow aspiration To use the sharing features on this page, please enable JavaScript. Bone marrow is the soft tissue inside bones that helps ...

  10. Bone marrow biopsy

    Science.gov (United States)

    Biopsy - bone marrow ... A bone marrow biopsy may be done in the health care provider's office or in a hospital. The sample may be taken from the pelvic or breast bone. Sometimes, other areas are used. Marrow is removed ...

  11. Anorexia Nervosa and Bone

    OpenAIRE

    Misra, Madhusmita; Klibanski, Anne

    2014-01-01

    Anorexia nervosa (AN) is a condition of severe low weight that is associated with low bone mass, impaired bone structure and reduced bone strength, all of which contribute to increased fracture risk., Adolescents with AN have decreased rates of bone accrual compared with normal-weight controls, raising addition concerns of suboptimal peak bone mass and future bone health in this age group. Changes in lean mass and compartmental fat depots, hormonal alterations secondary to nutritional factors...

  12. The CT flare response of metastatic bone disease in prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Messiou, Christina; deSouza, Nandita M. (Cancer Research UK Clinical Magnetic Resonance Research Group, Inst. of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey (United Kingdom)), email: Christina.Messiou@icr.ac.uk; Cook, Gary (Dept. of Nuclear Medicine, Royal Marsden NHS Foundation Trust, Surrey (United Kingdom)); Reid, Alison H.M.; Attard, Gerhardt; Dearnaley, David; deBono, Johann S. (Inst. of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey (United Kingdom))

    2011-06-15

    Background New or worsening bone lesions in patients responding to treatment, known as the flare phenomenon is well described on 99mTc-MDP bone scintigraphy, but to our knowledge has not previously been described on CT. The appearance of new or worsening bone sclerosis on CT in patients with prostate cancer may therefore be erroneously classified as disease progression. Purpose To assess the incidence of osteoblastic healing flare response at 3-month CT assessment in patients with castrate-resistant prostate cancer and to identify associated features that enable differentiation from progressive metastatic bone disease at 3 months. Material and Methods CT scans of 67 patients with castrate-resistant prostate cancer undergoing treatment were reviewed by a radiologist blinded to clinical outcome. Changes in number, size, and density of metastatic bone lesions were documented and Response Evaluation Criteria in Solid Tumours (RECIST) in soft tissue lesions, alkaline phosphatase, prostate specific antigen, and 99mTc-MDP bone scans were used for correlation. Results Of the 39 patients who had 3- and 6-month follow-up, eight patients (21%) demonstrated an increase in number, size, or density of sclerotic lesions on the 3-month CT scan despite improvement in PSA and soft tissue lesions. Three out of eight patients (8%) maintained partial response/remained stable at follow-up and were defined as showing a flare response: in this group bone metastases evident on CT showed a qualitative and quantitative increase in density and no lesions faded at 3 months. In contrast, in all patients who progressed at 3 months by PSA/RECIST criteria (n = 8) bone lesions showed a mixed pattern with some lesions increasing and others decreasing in density. Conclusion The incidence of flare response of metastatic bone disease evident at 3-month post-treatment CT in patients with prostate cancer undergoing systemic treatment is 8%. In patients with falling PSA and stable/responding soft tissue

  13. Bone marrow transplant - discharge

    Science.gov (United States)

    Transplant - bone marrow - discharge; Stem cell transplant - discharge; Hematopoietic stem cell transplant - discharge; Reduced intensity; Non-myeloablative transplant - discharge; Mini transplant - discharge; Allogenic bone marrow transplant - discharge; ...

  14. Long-term bone tissue reaction to polyethylene oxide/polybutylene terephthalate copolymer (Polyactive) in metacarpophalangeal joint reconstruction.

    Science.gov (United States)

    Waris, Eero; Ashammakhi, Nureddin; Lehtimäki, Mauri; Tulamo, Riitta-Mari; Törmälä, Pertti; Kellomäki, Minna; Konttinen, Yrjö T

    2008-06-01

    The poly-L/D-lactide 96/4 joint scaffolds are used to engineer fibrous tissue joints in situ for the reconstruction of metacarpophalangeal joints. In this experimental study, a supplementary elastomeric stem made of Polyactive 1000PEO70PBT30 (a segmented block copolymer of polyethylene oxide and polybutylene terephtalate with 70/30 PEO/PBT ratio) was used to anchor the joint scaffold in the arthroplasty space. Eleven resected fifth metacarpophalangeal joints of minipig were reconstructed and evaluated radiologically and histologically for 3 years. Plain joint scaffold and Swanson silicone implant arthroplasties (11 of each) in metacarpophalangeal joints of minipig served as controls. Altogether fore limbs of eighteen minipigs were operated for the study. Deleterious tissue reaction with dramatic signs of osteolysis and inflammatory foreign-body reaction was observed around the Polyactive stems. The mean maximum diameter of the osteolytic stem cavity was statistically wider when compared to the mean maximum diameter of Swanson implant group during the first postoperative year. Numerous osteoclasts were found at the margins of the osteolytic areas. No direct bone contact could be seen. At 1 year osteoblastic regeneration and formation of new trabecular bone followed. Finally the foreign-body reaction settled, but the adjoining bones were at this stage highly sclerotic and composed of coarse trabeculae. In contrary to previous in vivo studies suggesting biocompatibility, osteoconductivity and capability to bond to bone, Polyactive 1000PEO70PBT30 stem in this setting caused massive osteolytic lesions and foreign-body reactions. PMID:18336902

  15. Inactivated Bone Replantation with Preservation of the Epiphysis in Children with Osteosarcoma- Clinical Report of Two Cases

    Institute of Scientific and Technical Information of China (English)

    YUXiuchun; LIUXiaoping; ZHOUYin; LIKaihua; QUZaiping

    2005-01-01

    Objective: To evaluate the value of inactivated bone replantation with preservation of the epiphysis following the effective chemotherapy in avoiding postoperative discrepancy of the affected limb in children with osteosarcoma. Methods: Two children (aged 5 and 10 years, 1 male and 1 female) with osteosarcoma underwent inactivated bone replantation with preserving epiphysis following chemotherapy (MMIA protocol, including high-dose methotrexate, adriamycin and ifosfamide). After two cycles of preoperative chemotherapy, pain vanished, the local mass shrank and there was no pain on pressing the affected parts. Sera AKP and LDH were reduced to normal levels; marked shrinkage and sclerotic changes and good margin of lesions were seen on plain radiographs and MR images. Two courses of the same protocol as preoperative chemotherapy were administered postoperatively. Results: Postoperative histological examination of the specimens demonstrated absence of vital tumor cells. Incisions healed well and no complications occurred. The replanted inactivated bone healed with host at 6 months after operation.In the two patients, no evidence was seen of metastasis and recurrence and discrepancy of the affected limbs in postoperative 36 and 48 months. Functions of the affected limbs were satisfactory. Conclusion:Inactivated bone replantation with preserving epiphysis was a viable option for osteosarcoma in children.The long-term outcomes remain to be further proven.

  16. Snf7p, a Component of the ESCRT-III Protein Complex, Is an Upstream Member of the RIM101 Pathway in Candida albicans

    OpenAIRE

    Kullas, Amy L.; Li, Mingchun; Davis, Dana A.

    2004-01-01

    The success of Candida albicans as an opportunistic pathogen is based in part on its ability to adapt to diverse environments. The RIM101 pathway governs adaptation to neutral-alkaline environments and is required for virulence. Analysis of a genomic two-hybrid study conducted with Saccharomyces cerevisiae revealed that components involved in multivesicular bodies (MVB) transport may interact with RIM101 pathway members. Thus, we hypothesized that these proteins may function in the RIM101 pat...

  17. Virtual Quake and Tsunami Squares: Scenario Earthquake and Tsunami Simulations for a Pacific Rim GNSS Tsunami Early Warning System

    Science.gov (United States)

    Schultz, K.; Yoder, M. R.; Sachs, M. K.; Heien, E. M.; Donnellan, A.; Rundle, J. B.; Turcotte, D. L.

    2015-12-01

    Plans for the first operational prototype for a Pacific Rim Tsunami Early Warning (TEW) system utilizing real-time data from the Global Navigational Satellite System (GNSS) are now gaining momentum. The proposed Pacific Rim TEW prototype may resemble the Japanese Meteorological Society's early warning algorithms and use earthquake parameters rapidly determined from GPS data to select the most similar earthquake and tsunami scenario from a database of precomputed scenarios to guide alerts and disaster response. To facilitate the development of this Pacific Rim TEW system, we have integrated tsunami modeling capabilities into the earthquake simulator Virtual Quake (formerly Virtual California). We will present the first results from coupling the earthquake simulator output (seafloor displacements) with the tsunami modeling method called Tsunami Squares. Combining Virtual Quake and Tsunami Squares provides a highly scalable and flexible platform for producing catalogs of tsunami scenarios for a wide range of simulated subduction zone earthquakes.

  18. Modelo de tumor experimental em rim de ratos Experimental tumor model in rats kidney

    Directory of Open Access Journals (Sweden)

    Lúcio Flávio Gonzaga Silva

    2002-02-01

    Full Text Available O carcinossarcoma 256 de Walker tem despertado o interesse de muitos pesquisadores como modelo experimental para estudo da biologia tumoral. OBJETIVO: estabelecer um modelo de tumor renal que possa ser usado para estudar in vivo e in vitro, as alterações impostas pelas neoplasias. MÉTODOS: utilizados vinte ratos Wistar, machos, adultos, pesando entre 250-300 g, oriundos do Laboratório de Cirurgia Experimental da Universidade Federal do Ceará. Sob anestesia inalatória procedia-se uma pequena incisão supraumbilical, e com manobra delicada fazia-se a exposição do rim direito. Neste órgão eram inoculadas 3x10(5 células tumorais viáveis. Os animais então eram mantidos em gaiolas individuais com as mesmas condições ambientais e com água e dieta ad libitum. RESULTADOS: o Carcinossarcoma 256 de Walker, implantado no parênquima do rim direito de ratos Wistar apresentou índice de pega de 100%, e crescimento rápido, invadiu por contiguidade as estruturas vizinhas, porém sem apresentar metástases, no entanto, levando os animais a óbito no curso médio de 14 dias. CONCLUSÃO: o modelo de implante de tumor de Walker no parênquima do rim direito de ratos Wistar é eficiente, tem reprodutibilidade, apresentando um índice de pega de 100%, e permitindo seu uso em linhas de pesquisa.Walker carcinossarcoma 256 has a great interest as experimental model for studies on tumoral biology. OBJECTIVE: develop a kidney tumor model to be used in the evaluation of the biological behavior of neoplasms in vitro and in vivo environments. METHODS: twenty adult male Wistar rats weighting between 250-300 g were obtained from the Federal University of the Ceará Experimental Surgery Laboratory. Upon ether anesthesia, the right kidney of each animal was accessed through a supraumbelical incision and inoculated with a solution containing 3 x 10(5 tumor cells (Walker 256 carcinossarcoma tumor cells. Following anesthetic recovery the rats were returned to their

  19. Immediate impact on the rim zone of cement based materials due to chemical attack

    International Nuclear Information System (INIS)

    Cement based materials are in their widespread application fields exposed to various aqueous environments. This can lead to serious chemical changes affecting the durability of the materials. In particular in the context of service life prediction a detailed knowledge of the reaction mechanisms is a necessary base for the evaluation of the aggressivity of an aqueous medium and this is deduced commonly from long term investigations. However, these processes start immediately at the material/water-interface, when a cementitious system comes into contact with an aqueous solution, altering here the chemical composition and microstructure. This rim zone represents the first hurdle that has to be overcome by an attacking aqueous solution. Therefore, the properties of the surface near area should be closely associated with the further course of deterioration processes by reactive transport. In this context short term exposure experiments with hardened cement paste over 4 and 48 h have been carried out with demineralized water, hard tap water and different sulfate solutions. In order to investigate immediate changes in the near-surface region, depth profile cuts have been performed on the cement paste samples by means of focused ion beam preparation techniques. A scanning beam of Gallium ions is applied to cut a sharp edge in the cement paste surface, providing insights into the composition and microstructure of the upper ten to hundred microns. Electron microscopic investigations on such a section of the rim zone, together with surface sensitive X-ray diffraction accompanied by a detailed characterization of the bulk composition confirm that the properties of the material/water interface are of relevance for the durability of cement based systems in contact with aqueous solutions. In this manner, focused ion beam investigations constitute auspicious tools to contribute to a more sophisticated understanding of the reaction mechanisms. - Highlights: • The chemical

  20. Immediate impact on the rim zone of cement based materials due to chemical attack

    Energy Technology Data Exchange (ETDEWEB)

    Schwotzer, M., E-mail: matthias.schwotzer@kit.edu [Karlsruhe Institute of Technology (KIT), Institute of Functional Interfaces (IFG), Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany); Scherer, T. [Karlsruhe Institute of Technology (KIT), Institute of Nanotechnology (INT), Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany); Gerdes, A. [Karlsruhe Institute of Technology (KIT), Institute of Functional Interfaces (IFG), Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany); University of Applied Sciences Karlsruhe, Institute for Prevention in Construction, Moltkestr. 30, D-76133 Karlsruhe (Germany)

    2015-01-15

    Cement based materials are in their widespread application fields exposed to various aqueous environments. This can lead to serious chemical changes affecting the durability of the materials. In particular in the context of service life prediction a detailed knowledge of the reaction mechanisms is a necessary base for the evaluation of the aggressivity of an aqueous medium and this is deduced commonly from long term investigations. However, these processes start immediately at the material/water-interface, when a cementitious system comes into contact with an aqueous solution, altering here the chemical composition and microstructure. This rim zone represents the first hurdle that has to be overcome by an attacking aqueous solution. Therefore, the properties of the surface near area should be closely associated with the further course of deterioration processes by reactive transport. In this context short term exposure experiments with hardened cement paste over 4 and 48 h have been carried out with demineralized water, hard tap water and different sulfate solutions. In order to investigate immediate changes in the near-surface region, depth profile cuts have been performed on the cement paste samples by means of focused ion beam preparation techniques. A scanning beam of Gallium ions is applied to cut a sharp edge in the cement paste surface, providing insights into the composition and microstructure of the upper ten to hundred microns. Electron microscopic investigations on such a section of the rim zone, together with surface sensitive X-ray diffraction accompanied by a detailed characterization of the bulk composition confirm that the properties of the material/water interface are of relevance for the durability of cement based systems in contact with aqueous solutions. In this manner, focused ion beam investigations constitute auspicious tools to contribute to a more sophisticated understanding of the reaction mechanisms. - Highlights: • The chemical

  1. Bisphosphonate-Related Osteonecrosis of the Jaw Bone: Radiological Pattern and the Potential Role of CBCT in Early Diagnosis

    Directory of Open Access Journals (Sweden)

    James Olutayo

    2010-04-01

    Full Text Available Objectives: To systematize the clinico-radiological symptoms and course of bisphosphonate-related osteonecrosis of jaw bone and to evaluate the diagnostic potential of various radiological techniques to detect mild osteonecrosis in each stage of the disease.Material and Methods: The sample consisted of 22 patients previously diagnosed with extraoral malignant disease. Diagnosis was based on a clinical examination in conjunction to digital panoramic radiography and cone beam computed tomography (CBCT. Two dentomaxillofacial radiologists reviewed all images.Results: Twenty patients showed mandibular involvement clinically, while two others had a maxillary involvement. Four stages of the disease were proposed based on the clinico-radiological findings. Subclinical cortical and lamina dura thickening was detected with only three-dimensional CBCT and periapical images, while ulceration and cortical bone thickening was detected only by three-dimensional CBCT. Mixed sclerotic, lytic bone destruction involving alveolar and basal bone with or without encroachment on the mandibular canal, pathological mandibular fractures were detected by two-dimensional panoramic and three-dimensional CBCT images. Other findings are non healing extraction sockets, periapical radiolucencies, osteolysis, sequestra, oroantral fistula, and periosteal new bone formation.Conclusions: The present study showed that bisphosphonate-related osteonecrosis of jaw bone occurs in four distinct clinico-radiological stages. For mild cases, panoramic image diagnosis was much less obvious, whereas cone beam computed tomography was able to fully characterise the bony lesions and describe their extent and involvement of neighbouring structures in all cases. Thus cone beam computed tomography might better contribute to the prevention of bisphosphonate-related osteonecrosis of jaw bone as well to the disease management.

  2. Growth and instability of the liquid rim in the crown splash regime

    CERN Document Server

    Agbaglah, G

    2014-01-01

    We study the formation, growth, and disintegration of jets following impact of a drop on a thin film of the same liquid for We < 1000 and Re < 2000 using a combination of numerical simulations and linear stability theory (Agbaglah et al. 2013). Our simulations faithfully capture this phenomena and are in good agreement with experimental profiles obtained from high-speed X-ray imaging.We obtain scaling relations from our simulations and use these as inputs to our stability analysis. The resulting prediction for the most unstable wavelength are in excellent agreement with experimental data. Our calculations show that the dominant destabilizing mechanism is a competition between capillarity and inertia but that deceleration of the rim provides an additional boost to growth. We also predict over the entire parameter range of our study the number and timescale for formation of secondary droplets formed during a splash, based on the assumption that the most unstable mode sets the droplet number.

  3. Salicylaldiminato derivatives of cyclotriveratrylene: flexible strategy for new rim-metalated CTV complexes.

    Science.gov (United States)

    Bohle, D S; Stasko, D J

    2000-12-11

    The amino-derivatized cyclotriveratrylene analogue, triaminotrimethoxytribenzocyclononene [CTV(NH2)3(OMe)3], 1, is readily converted into triply substituted imine compounds [CTV(sal)3(OMe)3], 2, in high yield by treatment of the acid salt of 1 with a variety of substituted salicylaldehydes. Cleavage of the protecting methoxy group generates the tristridentate chelate CTV(sal)3(OH)3, 3, which is readily converted into new rim-metalated species CTV(sal)3(ONiL)3, 4a (a, L = pyrrolidine; b, L = 1-n-butyl-imidazole). Taken together, these results illustrate the remarkable synthetic flexibility that is possible for the CTV-based metal complexes by alteration of the metal, the salicylaldehyde component of the CTV ligand, or the ancillary ligands coordinated to the metal. PMID:11151378

  4. High-R Walls for New Construction Structural Performance: Integrated Rim Header Testing

    Energy Technology Data Exchange (ETDEWEB)

    DeRenzis, A. [NAHB Research Center, Upper Marlboro, MD (United States); Kochkin, V. [NAHB Research Center, Upper Marlboro, MD (United States); Wiehagen, J. [NAHB Research Center, Upper Marlboro, MD (United States)

    2013-01-01

    Two prominent approaches within the Building America Program to construct higher R-value walls have included use of larger dimension framing and exterior rigid foam insulation. These approaches have been met with some success; however for many production builders, where the cost of changing framing systems is expensive, the changes have been slow to be realized. In addition, recent building code changes have raised some performance issues for exterior sheathing and raised heel trusses, for example, that indicates a need for continued performance testing for wall systems. The testing methods presented in this report evaluate structural rim header designs over openings up to 6 ft wide and applicable to one- and two-story homes.

  5. MODELING AND FATIGUE ANALYSIS OF AUTOMOTIVE WHEEL RIM WITH DIFFERENT MATERIALS

    Directory of Open Access Journals (Sweden)

    MERIGE PHANI SRUJAN

    2016-08-01

    Full Text Available In the design of automobile, the industry is exploringpolymericmaterial in order to obtain reduction of weight withoutsignificantdecrease in vehicle quality and reliability. Fuel consumption of the vehicle is directly proportional to the weight of the wheel rim. Thusin this project a standard wheel of four wheeler ischosenand analyzed by applying loads and using different materials .AluminumAlloy,Magnesium Alloy, PEEK,PEEK with 20% Glassfiber, PEEK with 30% GlassFiber are the materials chosen.The whole design is made by using SOLIDWORKS as per original equipment manufacturer(OEM’Srequirement. Analysis has been carried out using ANSYS todetermine deformation and fatigue life of the wheel. The whole analysisisdonebymeansofsoftwarethereforeresultandobservationsaretrustworthy and met ourexpectation.

  6. Descemet membrane endothelial keratoplasty with a stromal rim in the treatment of posterior polymorphous corneal dystrophy

    Directory of Open Access Journals (Sweden)

    Pavel Studeny

    2012-01-01

    Full Text Available A 20-year-old patient, diagnosed with posterior polymorphous corneal dystrophy, developed corneal edema for which he underwent Descemet membrane endothelial keratoplasty with a stromal rim (DMEK-S in the right eye. No intra- or postoperative complications were noted. At the last follow-up 2 years and 9 months after the procedure, the best corrected visual acuity was 1.0 and endothelial cell density declined from 3533 cells/mm 2 to 1012 cells/mm 2 . Despite the endothelial cell loss, DMEK-S appears to be a good alternative to other surgical techniques for the treatment of corneal endotheliopathies, and it may be of benefit to young patients.

  7. Bone grafting: An overview

    Directory of Open Access Journals (Sweden)

    D. O. Joshi

    2010-08-01

    Full Text Available Bone grafting is the process by which bone is transferred from a source (donor to site (recipient. Due to trauma from accidents by speedy vehicles, falling down from height or gunshot injury particularly in human being, acquired or developmental diseases like rickets, congenital defects like abnormal bone development, wearing out because of age and overuse; lead to bone loss and to replace the loss we need the bone grafting. Osteogenesis, osteoinduction, osteoconduction, mechanical supports are the four basic mechanisms of bone graft. Bone graft can be harvested from the iliac crest, proximal tibia, proximal humerus, proximal femur, ribs and sternum. An ideal bone graft material is biologically inert, source of osteogenic, act as a mechanical support, readily available, easily adaptable in terms of size, shape, length and replaced by the host bone. Except blood, bone is grafted with greater frequency. Bone graft indicated for variety of orthopedic abnormalities, comminuted fractures, delayed unions, non-unions, arthrodesis and osteomyelitis. Bone graft can be harvested from the iliac crest, proximal tibia, proximal humerus, proximal femur, ribs and sternum. By adopting different procedure of graft preservation its antigenicity can be minimized. The concept of bone banking for obtaining bone grafts and implants is very useful for clinical application. Absolute stability require for successful incorporation. Ideal bone graft must possess osteogenic, osteoinductive and osteocon-ductive properties. Cancellous bone graft is superior to cortical bone graft. Usually autologous cancellous bone graft are used as fresh grafts where as allografts are employed as an alloimplant. None of the available type of bone grafts possesses all these properties therefore, a single type of graft cannot be recomm-ended for all types of orthopedic abnormalities. Bone grafts and implants can be selected as per clinical problems, the equipments available and preference of

  8. Bone scan in rheumatology

    International Nuclear Information System (INIS)

    In this chapter a revision is made concerning different uses of bone scan in rheumatic diseases. These include reflex sympathetic dystrophy, osteomyelitis, spondyloarthropaties, metabolic bone diseases, avascular bone necrosis and bone injuries due to sports. There is as well some comments concerning pediatric pathology and orthopedics. (authors). 19 refs., 9 figs

  9. Bone Marrow Transplantation

    Science.gov (United States)

    Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The ... platelets, which help the blood to clot. A bone marrow transplant is a procedure that replaces a ...

  10. Bone grafts in dentistry

    Directory of Open Access Journals (Sweden)

    Prasanna Kumar

    2013-01-01

    Full Text Available Bone grafts are used as a filler and scaffold to facilitate bone formation and promote wound healing. These grafts are bioresorbable and have no antigen-antibody reaction. These bone grafts act as a mineral reservoir which induces new bone formation.

  11. Distal myopathy with rimmed vacuoles: Report on clinical characteristics in 23 cases

    Directory of Open Access Journals (Sweden)

    Nalini A

    2010-01-01

    Full Text Available Background: Distal myopathy with rimmed vacuoles (DMRV is an autosomal recessive (AR myopathy characterized clinically by the preferential involvement of the tibialis anterior and has been reported predominantly in the Japanese population. Materials and Methods: A case series of DMRV patients seen over a period of 3 years at a tertiary national referral center for neurological disorders in south India. Results: We describe the clinical characteristics, muscle magnetic resonance imaging (MRI findings and classical histopathological feature in 23 patients. There were 12 men and 11 women. Mean age of onset was 27.04 ± 6.35 years (10-39 years. Onset was in the second or third decade in a majority. Mean age at presentation was 33.95 ± 6.35 years (25-48 years. Mean duration of illness was 6.74 ± 4.8 years (1-18 years. Consanguinity was reported in eight (34.8% patients. The predominant and initial manifestation was bilateral foot drop in all patients. Muscle MRI demonstrated classical involvement of the anterior compartment muscles of the lower legs and the posterior compartment muscles of the thighs and the quadriceps was normal in all. Muscle histopathology showed numerous fibers containing rimmed vacuoles. Necrotic fibers or phagocytosis or regenerating fibers were rarely noted or were absent. Conclusions: DMRV is a rare AR myopathy. The disorder presents as progressive foot drop and hence has many differential diagnoses. It is easily mistaken as neuropathy of hereditary nature and hence it is extremely important to recognize the preferential muscle involvement and characterize the phenotype. This is the first report from India with patients having characteristic phenotype of Nonaka′s/AR hereditary inclusion body myopathy with quadriceps sparing, and all were confirmed by histopathology.

  12. THE REFINED SHOCK VELOCITY OF THE X-RAY FILAMENTS IN THE RCW 86 NORTHEAST RIM

    Energy Technology Data Exchange (ETDEWEB)

    Yamaguchi, Hiroya; Castro, Daniel; Williams, Brian J.; Petre, Robert [NASA Goddard Space Flight Center, Code 662, Greenbelt, MD 20771 (United States); Katsuda, Satoru [Institute of Space and Astronautical Science, JAXA, 3-1-1 Yoshinodai, Sagamihara, Kanagawa 229-8510 (Japan); Lopez, Laura A. [Department of Astronomy and Center for Cosmology and Astro-Particle Physics, The Ohio State University, Columbus, OH 43210 (United States); Slane, Patrick O.; Smith, Randall K., E-mail: hiroya.yamaguchi@nasa.gov [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States)

    2016-03-20

    A precise measurement of shock velocities is crucial for constraining the mechanism and efficiency of cosmic-ray (CR) acceleration at supernova remnant (SNR) shock fronts. The northeastern rim of the SNR RCW 86 is thought to be a particularly efficient CR acceleration site, owing to the recent result in which an extremely high shock velocity of ∼6000 km s{sup −1} was claimed. Here, we revisit the same SNR rim with the Chandra X-ray Observatory, 11 years after the first observation. This longer baseline than previously available allows us to determine a more accurate proper motion of the nonthermal X-ray filament, revealing a much lower velocity of 3000 ± 340 km s{sup −1} (and even slower at a brighter region). Although the value has dropped to one-half of that from the previous X-ray measurement, it is still higher than the mean velocity of the Hα filaments in this region (∼1200 km s{sup −1}). This discrepancy implies that the filaments bright in nonthermal X-rays and Hα emission trace different velocity components, and thus a CR pressure constrained by combining the X-ray kinematics and the Hα spectroscopy can easily be overestimated. We also measure the proper motion of the thermal X-ray filament immediately to the south of the nonthermal one. The inferred velocity (720 ± 360 km s{sup −1}) is significantly lower than that of the nonthermal filament, suggesting the presence of denser ambient material, possibly a wall formed by a wind from the progenitor, which has drastically slowed down the shock.

  13. Nonthermal emission properties of the northwestern rim of supernova remnant RX J0852.0-4622

    Science.gov (United States)

    Kishishita, T.; Hiraga, J.; Uchiyama, Y.

    2013-03-01

    The supernova remnant (SNR) RX J0852.0-4622 (Vela Jr., G266.6-1.2) is one of the most important SNRs for investigating the acceleration of multi-TeV particles and the origin of Galactic cosmic rays because of its strong synchrotron X-ray and TeV γ-ray emission, which show a shell-like morphology similar to each other. Using the XMM-Newton archival data consisting of multiple pointing observations of the northwestern rim of the remnant, we investigate the spatial properties of the nonthermal X-ray emission as a function of distance from an outer shock wave. All X-ray spectra are well reproduced by an absorbed power-law model above 2 keV. It is found that the spectra show gradual softening from a photon index Γ = 2.56 in the rim region to Γ = 2.96 in the interior region. We show that this radial profile can be interpreted as a gradual decrease of the cutoff energy of the electron spectrum due to synchrotron cooling. By using a simple spectral evolution model that includes continuous synchrotron losses, the spectral softening can be reproduced with the magnetic field strength in the post-shock flow to less than several tens of μG. If this is a typical magnetic field in the SNR shell, γ-ray emission would be accounted for by inverse Compton scattering of high-energy electrons that also produce the synchrotron X-ray emission. Future hard X-ray imaging observations with Nustar and ASTRO-H and TeV γ-ray observations with the Cherenkov Telescope Array (CTA) will allow us to explore other possible explanations of the systematic softening of the X-ray spectra.

  14. RPPAML/RIMS: A metadata format and an information management system for reverse phase protein arrays

    Science.gov (United States)

    Stanislaus, Romesh; Carey, Mark; Deus, Helena F; Coombes, Kevin; Hennessy, Bryan T; Mills, Gordon B; Almeida, Jonas S

    2008-01-01

    Background Reverse Phase Protein Arrays (RPPA) are convenient assay platforms to investigate the presence of biomarkers in tissue lysates. As with other high-throughput technologies, substantial amounts of analytical data are generated. Over 1000 samples may be printed on a single nitrocellulose slide. Up to 100 different proteins may be assessed using immunoperoxidase or immunoflorescence techniques in order to determine relative amounts of protein expression in the samples of interest. Results In this report an RPPA Information Management System (RIMS) is described and made available with open source software. In order to implement the proposed system, we propose a metadata format known as reverse phase protein array markup language (RPPAML). RPPAML would enable researchers to describe, document and disseminate RPPA data. The complexity of the data structure needed to describe the results and the graphic tools necessary to visualize them require a software deployment distributed between a client and a server application. This was achieved without sacrificing interoperability between individual deployments through the use of an open source semantic database, S3DB. This data service backbone is available to multiple client side applications that can also access other server side deployments. The RIMS platform was designed to interoperate with other data analysis and data visualization tools such as Cytoscape. Conclusion The proposed RPPAML data format hopes to standardize RPPA data. Standardization of data would result in diverse client applications being able to operate on the same set of data. Additionally, having data in a standard format would enable data dissemination and data analysis. PMID:19102773

  15. RPPAML/RIMS: A metadata format and an information management system for reverse phase protein arrays

    Directory of Open Access Journals (Sweden)

    Hennessy Bryan T

    2008-12-01

    Full Text Available Abstract Background Reverse Phase Protein Arrays (RPPA are convenient assay platforms to investigate the presence of biomarkers in tissue lysates. As with other high-throughput technologies, substantial amounts of analytical data are generated. Over 1000 samples may be printed on a single nitrocellulose slide. Up to 100 different proteins may be assessed using immunoperoxidase or immunoflorescence techniques in order to determine relative amounts of protein expression in the samples of interest. Results In this report an RPPA Information Management System (RIMS is described and made available with open source software. In order to implement the proposed system, we propose a metadata format known as reverse phase protein array markup language (RPPAML. RPPAML would enable researchers to describe, document and disseminate RPPA data. The complexity of the data structure needed to describe the results and the graphic tools necessary to visualize them require a software deployment distributed between a client and a server application. This was achieved without sacrificing interoperability between individual deployments through the use of an open source semantic database, S3DB. This data service backbone is available to multiple client side applications that can also access other server side deployments. The RIMS platform was designed to interoperate with other data analysis and data visualization tools such as Cytoscape. Conclusion The proposed RPPAML data format hopes to standardize RPPA data. Standardization of data would result in diverse client applications being able to operate on the same set of data. Additionally, having data in a standard format would enable data dissemination and data analysis.

  16. Bone Health and Osteoporosis.

    Science.gov (United States)

    Lupsa, Beatrice C; Insogna, Karl

    2015-09-01

    Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue leading to decreased bone strength and an increased risk of low-energy fractures. Central dual-energy X-ray absorptiometry measurements are the gold standard for determining bone mineral density. Bone loss is an inevitable consequence of the decrease in estrogen levels during and following menopause, but additional risk factors for bone loss can also contribute to osteoporosis in older women. A well-balanced diet, exercise, and smoking cessation are key to maintaining bone health as women age. Pharmacologic agents should be recommended in patients at high risk for fracture.

  17. BONE IN OSTEOPETROSIS

    Directory of Open Access Journals (Sweden)

    Ramkumar

    2014-04-01

    Full Text Available Osteopetrosis, a generalized developmental bone disease due to genetic disturbances, characterized by failure of bone re sorption and continuous bone formation making the bone hard, dense and brittle. Bones of intramembranous ossification and enchondrial ossification are affected genetically and symmetrically. During the process of disease the excess bone formation obliterates the cranial foramina and presses the optic, auditory and facial nerves resulting in defective vision, impaired hearing and facial paralysis. The bone formation in osteopetrosis affects bone marrow function leading to severe anemia and deficient of blood cells. The bone devoid of blood supply due to compression of blood vessels by excess formation of bone are prone to osteomyelitic changes with suppuration and pathological fracture if exposed to infection. Though the condition is chronic progressive, it produces changes leading to fatal condition, it should be studied thoroughly by everyone and hence this article presents a classical case of osteopetrosis with detailed description and discussion for the benefit of readers

  18. Management of subtrochanteric femur fractures with internal fixation and recombinant human bone morphogenetic protein-7 in a patient with osteopetrosis: a case report

    Directory of Open Access Journals (Sweden)

    Golden Robert D

    2010-05-01

    Full Text Available Abstract Introduction Osteopetrosis is a group of conditions characterized by defects in the osteoclastic function of the bone resulting in defective bone resorption. Clinically, the condition is characterized by a dense, sclerotic, deformed bone which, despite an increased density observable by radiography, often results in an increased propensity to fracture and delayed union. Case Presentation We report the case of a 27-year-old Asian man presenting with bilateral subtrochanteric femur fractures. He had a displaced right subtrochanteric femur fracture after a low-energy fall, which was treated surgically. The second fracture that our patient endured was diagnosed as a stress fracture ten weeks later when he complained of pain in the contralateral left thigh. By that time, the right-sided fracture exhibited no radiographic evidence of healing, and when the left-sided stress fracture was being treated surgically, bone grafting with recombinant human bone morphogenetic protein-7 was also performed on the right side. Conclusion While there are no data supporting the use of bone morphogenic proteins in the management of delayed healing in patients with osteopetrosis, no other reliable osteoinductive grafting options are available to treat this condition. Both fractures in our patient healed, but based on the serial radiographic assessment it is uncertain to what degree the recombinant human bone morphogenetic protein-7 may have contributed to the successful outcome. It may have also contributed to the formation of heterotopic bone around the fracture site. Further investigation of the effectiveness and indications of bone morphogenic protein use for the management of delayed fracture healing in patients with osteopetrosis is warranted.

  19. Bone cysts: unicameral and aneurysmal bone cyst.

    Science.gov (United States)

    Mascard, E; Gomez-Brouchet, A; Lambot, K

    2015-02-01

    Simple and aneurysmal bone cysts are benign lytic bone lesions, usually encountered in children and adolescents. Simple bone cyst is a cystic, fluid-filled lesion, which may be unicameral (UBC) or partially separated. UBC can involve all bones, but usually the long bone metaphysis and otherwise primarily the proximal humerus and proximal femur. The classic aneurysmal bone cyst (ABC) is an expansive and hemorrhagic tumor, usually showing characteristic translocation. About 30% of ABCs are secondary, without translocation; they occur in reaction to another, usually benign, bone lesion. ABCs are metaphyseal, excentric, bulging, fluid-filled and multicameral, and may develop in all bones of the skeleton. On MRI, the fluid level is evocative. It is mandatory to distinguish ABC from UBC, as prognosis and treatment are different. UBCs resolve spontaneously between adolescence and adulthood; the main concern is the risk of pathologic fracture. Treatment in non-threatening forms consists in intracystic injection of methylprednisolone. When there is a risk of fracture, especially of the femoral neck, surgery with curettage, filling with bone substitute or graft and osteosynthesis may be required. ABCs are potentially more aggressive, with a risk of bone destruction. Diagnosis must systematically be confirmed by biopsy, identifying soft-tissue parts, as telangiectatic sarcoma can mimic ABC. Intra-lesional sclerotherapy with alcohol is an effective treatment. In spinal ABC and in aggressive lesions with a risk of fracture, surgical treatment should be preferred, possibly after preoperative embolization. The risk of malignant transformation is very low, except in case of radiation therapy.

  20. 76 FR 55708 - Servicing Multi-Piece and Single Piece Rim Wheels; Extension of the Office of Management and...

    Science.gov (United States)

    2011-09-08

    ... Occupational Safety and Health Administration Servicing Multi-Piece and Single Piece Rim Wheels; Extension of... Reduction Act of 1995 (44 U.S.C. 3506 et seq.) and Secretary of Labor's Order No. 4-2010 (75 FR 55355...) Requirements AGENCY: Occupational Safety and Health Administration (OSHA), Labor. ACTION: Request for...

  1. Structural uplift and ejecta thickness of lunar mare craters: New insights into the formation of complex crater rims

    Science.gov (United States)

    Krüger, Tim; Kenkmann, Thomas

    2015-04-01

    Most complex impact craters on solid planetary surfaces throughout the Solar System exhibit elevated crater rims similar to the elevated crater rims of simple craters. In principal the final elevation of the crater rim is due to the deposition of ejecta on the structurally uplifted bedrock of the pre-impact surface. For simple craters the elevated crater rim is due to two well understood factors: (i) Emplacement of the coherent proximal ejecta material at the transient cavity rim (overturned flap) [1]. (ii) Structural uplift of the pre-impact surface in the proximity of the transient cavity [1, 2]. The amount of structural uplift at the rim of simple craters is due to plastic thickening of the target rock, the emplacement of interthrust wedges and/or the injection of dike material in the underlying target [1, 2, 3, 4]. Both factors, (i) and (ii), are believed to equally contribute to the structural uplift of simple craters. Larger craters have complex morphologies and the crater's extent may considerably exceed that of the transient cavity due to gravity-driven adjustment movements. For instance, the Ries crater's final diameter is twice of its transient cavity size. It is expected that both ejecta thickness and structural uplift decrease with increasing distance from the rim of the transient crater. For lunar craters the continuous ejecta extends up to 2 crater radii from the crater center. The ejecta blanket thickness ET at the rim crest of the transient crater (which is inside the final crater) is a function of the distance r from the crater center, with RT as the radius of the transient crater [2, 6, 7] and is expressed by the following function: (1) ET = 0.033 RT (r/RT)^-3.0 for r ≥ RT [5, 6] The structural uplift is largest at the transient cavity rim and gets rapidly smaller with increasing distance to the crater center and disappears after 1.3 - 1.7 crater radii [1]. These circumstances raise the question, how elevated rims of complex craters form? Based

  2. Biochemical evidence for relaxed substrate specificity of Nα-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis

    Science.gov (United States)

    Pathak, Deepika; Bhat, Aadil Hussain; Sapehia, Vandana; Rai, Jagdish; Rao, Alka

    2016-01-01

    Nα-acetylation is a naturally occurring irreversible modification of N-termini of proteins catalyzed by Nα-acetyltransferases (NATs). Although present in all three domains of life, it is little understood in bacteria. The functional grouping of NATs into six types NatA - NatF, in eukaryotes is based on subunit requirements and stringent substrate specificities. Bacterial orthologs are phylogenetically divergent from eukaryotic NATs, and only a couple of them are characterized biochemically. Accordingly, not much is known about their substrate specificities. Rv3420c of Mycobacterium tuberculosis is a NAT ortholog coding for RimIMtb. Using in vitro peptide-based enzyme assays and mass-spectrometry methods, we provide evidence that RimIMtb is a protein Nα-acetyltransferase of relaxed substrate specificity mimicking substrate specificities of eukaryotic NatA, NatC and most competently that of NatE. Also, hitherto unknown acetylation of residues namely, Asp, Glu, Tyr and Leu by a bacterial NAT (RimIMtb) is elucidated, in vitro. Based on in vivo acetylation status, in vitro assay results and genetic context, a plausible cellular substrate for RimIMtb is proposed. PMID:27353550

  3. Radiation thermo-chemical models of protoplanetary discs : III. Impact of inner rims on spectral energy distributions

    NARCIS (Netherlands)

    Thi, W. -F.; Woitke, P.; Kamp, I.

    2011-01-01

    We study the hydrostatic density structure of the inner disc rim around Herbig Ae stars using the thermo-chemical hydrostatic code prodimo. We compare the spectral energy distributions (SEDs) and images from our hydrostatic disc models to that from prescribed density structure discs. The 2D continuu

  4. Spatially Resolved XRF, XRD and Fe-XANES Analysis of Fine-Grained Rims in the Murchison (CM2) Meteorite

    Science.gov (United States)

    King, A. J.; Schofield, P. F.; Mosselmans, J. F. W.; Russell, S. S.

    2014-09-01

    Fe3+/ΣFe ratios suggest that hydration of fine-grained rims and matrix in the Murchison meteorite occurred in a similar environment. However, local variations in mineralogy and crystal chemistry indicate that the alteration varied at the μm-scale.

  5. Influence of task complexity on mechanical efficiency and propulsion technique during learning of hand rim wheelchair propulsion

    NARCIS (Netherlands)

    de Groot, S; Veeger, H E J; Hollander, A P; van der Woude, L H V

    2005-01-01

    OBJECTIVE: To investigate the consequence of task complexity on gross mechanical efficiency and propulsion technique during the learning process of hand rim wheelchair propulsion. METHODS: Three groups of unimpaired subjects (N=10 each) received a 3-week wheelchair practice period (3 week(-1), nine

  6. Photodissociation of RbI in an Intense Laser Field: Detection of the Product Metal Atom Rb Using RIMS

    Institute of Scientific and Technical Information of China (English)

    HUO Binghai; GAO Jie; CUI Shuanjin; H. H. Telle; Z. T. Salim

    2000-01-01

    It is reported on the recent research using resonant ionization spectroscopy (RIS) and resonant ionization mass spectroscopy (RIMS) to detect the photodissociation product of Rubidium iodide molecules in a molecular beam in an intense laser field. Time of flight mass spectra is recorded. In particular, the appearances of multiphoton ionization are discussed.

  7. An Examination of the Factorial Invariance and Refinement of the Multidimensional School Anger Inventory for Five Pacific Rim Countries

    Science.gov (United States)

    Furlong, Michael J.; You, Sukkyung; Smith, Douglas C.; Gonzalez, Victoria; Boman, Peter; Shimoda, Yoshiyuki; Terasaka, Akiko; Merino, Cesar; Grazioso, María del Pilar

    2013-01-01

    The validity of the Multidimensional School Anger Inventory (MSAI) was examined with adolescents from 5 Pacific Rim countries (N = 3,181 adolescents; age, M = 14.8 years; 52% females). Confirmatory factor analyses examined configural invariance for the MSAI's anger experience, hostility, destructive expression, and anger coping subscales. The…

  8. Heterogenous Oxygen Isotopic Composition of a Complex Wark-Lovering Rim and the Margin of a Refractory Inclusion from Leoville

    Science.gov (United States)

    Simon, J. I.; Matzel, J. E. P.; Simon, S. B.; Weber, P. K.; Grossman, L.; Ross, D. K.; Hutcheon, I. D.

    2014-01-01

    Wark-Lovering (WL) rims [1] surrounding many refractory inclusions represent marker events in the early evolution of the Solar System in which many inclusions were exposed to changes in pressure [2], temperature [3], and isotopic reservoirs [4-7]. The effects of these events can be complex, not only producing mineralogical variability of WL rims [2], but also leading to mineralogical [8-10] and isotopic [7, 11, 12] changes within inclusion interiors. Extreme oxygen isotopic heterogeneity measured in CAIs has been explained by mixing between distinct oxygen gas reservoirs in the nebula [13]. Some WL rims contain relatively simple mineral layering and/or are isotopically homogeneous [14, 15]. As part of a larger effort to document and understand the modifications observed in some CAIs, an inclusion (L6) with a complex WL rim from Leoville, a member of the reduced CV3 subgroup was studied. Initial study of the textures and mineral chemistry was presented by [16]. Here we present NanoSIMS oxygen isotopic measurements to complement these petrologic observations.

  9. The Effects of Self-Shadowing by a Puffed up Inner Rim in Scattered Light Images of Protoplanetary Disks

    CERN Document Server

    Dong, Ruobing

    2015-01-01

    We explore whether protoplanetary disks with self-shadowing from puffed up inner rims exhibit observable features in scattered light images. We use both self-consistent hydrostatic equilibrium calculations and parameterized models to produce the vertically puffed up inner rims. We find that, in general, the transition between the shadowed and flared regions occurs in a smooth manner over a broad radius range, and no sudden jump exists at the outer edge of the shadow in either the disk temperature or density structures. As a result, a puffed up rim cannot create sharp ring/arc/spiral-arm-like features in the outer disk as have been detected in recent direct NIR imaging of disks. On the other hand, if the puffed up rim has a sharp edge in the vertical direction, the shadowing effect can produce a distinct 3-stage broken power law in the radial intensity profile of the scattered light, with 2 steep surface brightness radial profiles in the inner and outer disk joined by a shallow transition region around the sha...

  10. 16 CFR Table 3 to Part 1512 - Minimum Acceptable Values for the Quantity A Defined in the Retroreflective Tire and Rim Test...

    Science.gov (United States)

    2010-01-01

    ... Defined in the Retroreflective Tire and Rim Test Procedure 3 Table 3 to Part 1512 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT REGULATIONS REQUIREMENTS FOR BICYCLES... Retroreflective Tire and Rim Test Procedure Observation angle (degrees) Entrance angle (degrees)...

  11. Experimental study on the rim-enhancing lesion of rabbit brain abscess : MR imaging and histopathologic correlation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hee Jung; Suh, Soo Jhi; Kim, Sang Pyo; Joo, Yang Goo; Zeon, Seok Kil; Woo, Seong Ku [Keimyung Univ. School of Medicine, Taegu (Korea, Republic of)

    1996-11-01

    To evaluate on the basis of histopathologic carrelation the MR findings of mature brain abscess in the rabbit, with particular attention to rim-enhancing lesions. The evolution of abscess formation was obtained by the direct inoculation of Staphylococcus aureus into the gray-white matter junctions of the brains of 16 rabbits. The stages of brain abscesses were divided into four : early cerebritis (days 1 to 5 after inoculation of the organism);late cerebritis (days 6 to 14);early capsular (days 16 to 21);and late capsular (days 22 to 28). The available MR images showed 14 cases at the stage of early cerebritis, seven at the late cerebritis stage, three at the early capsular, and one at the late capsular stage. According to the known pathology of brain abscesses and on the basis of both MR imaging and histopathologic findings, the lesions were grouped according to whether they were found in the central necrotic, border, or peripheral zone. We analyzed the patterns of rim-enhancement (completeness of the rim, thickness, and margin) and the signal intensities of the abscess walls on MR images at each stage. Histopathologic correlation was performed in one case of each stage. We evaluated the presence or absence and degree of infiltration by inflammatory granulation tissue, microhemorrhage, reticulin, collagen, and hemosiderin of the abscess walls. Rim-enhancing lesions were present in three of 14 cases at the late cerebritis stage, in all three cases at the early capsular, in one at the late capsular, but in none at the early cerebritis stage. The enhancing pattern of the late cerebritis stage was irregular-margined incomplete rim-enhancement, with irregular thickness of the abscess walls (3/3). The enhancing pattern of the capsular stages was well-defined, complete rim-enhancement with uniform thickness of the abscess walls (3/4). The signal intensities of the abscess walls at the late cerebritis and early capsular stages were variable. The late capsular stage ws

  12. Experimental study on the rim-enhancing lesion of rabbit brain abscess : MR imaging and histopathologic correlation

    International Nuclear Information System (INIS)

    To evaluate on the basis of histopathologic carrelation the MR findings of mature brain abscess in the rabbit, with particular attention to rim-enhancing lesions. The evolution of abscess formation was obtained by the direct inoculation of Staphylococcus aureus into the gray-white matter junctions of the brains of 16 rabbits. The stages of brain abscesses were divided into four : early cerebritis (days 1 to 5 after inoculation of the organism);late cerebritis (days 6 to 14);early capsular (days 16 to 21);and late capsular (days 22 to 28). The available MR images showed 14 cases at the stage of early cerebritis, seven at the late cerebritis stage, three at the early capsular, and one at the late capsular stage. According to the known pathology of brain abscesses and on the basis of both MR imaging and histopathologic findings, the lesions were grouped according to whether they were found in the central necrotic, border, or peripheral zone. We analyzed the patterns of rim-enhancement (completeness of the rim, thickness, and margin) and the signal intensities of the abscess walls on MR images at each stage. Histopathologic correlation was performed in one case of each stage. We evaluated the presence or absence and degree of infiltration by inflammatory granulation tissue, microhemorrhage, reticulin, collagen, and hemosiderin of the abscess walls. Rim-enhancing lesions were present in three of 14 cases at the late cerebritis stage, in all three cases at the early capsular, in one at the late capsular, but in none at the early cerebritis stage. The enhancing pattern of the late cerebritis stage was irregular-margined incomplete rim-enhancement, with irregular thickness of the abscess walls (3/3). The enhancing pattern of the capsular stages was well-defined, complete rim-enhancement with uniform thickness of the abscess walls (3/4). The signal intensities of the abscess walls at the late cerebritis and early capsular stages were variable. The late capsular stage ws

  13. Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch.

    Directory of Open Access Journals (Sweden)

    Jun Lu

    2006-07-01

    Full Text Available C(2 domains are well characterized as Ca(2+/phospholipid-binding modules, but little is known about how they mediate protein-protein interactions. In neurons, a Munc13-1 C(2A-domain/RIM zinc-finger domain (ZF heterodimer couples synaptic vesicle priming to presynaptic plasticity. We now show that the Munc13-1 C(2A domain homodimerizes, and that homodimerization competes with Munc13-1/RIM heterodimerization. X-ray diffraction studies guided by nuclear magnetic resonance (NMR experiments reveal the crystal structures of the Munc13-1 C(2A-domain homodimer and the Munc13-1 C(2A-domain/RIM ZF heterodimer at 1.44 A and 1.78 A resolution, respectively. The C(2A domain adopts a beta-sandwich structure with a four-stranded concave side that mediates homodimerization, leading to the formation of an eight-stranded beta-barrel. In contrast, heterodimerization involves the bottom tip of the C(2A-domain beta-sandwich and a C-terminal alpha-helical extension, which wrap around the RIM ZF domain. Our results describe the structural basis for a Munc13-1 homodimer-Munc13-1/RIM heterodimer switch that may be crucial for vesicle priming and presynaptic plasticity, uncovering at the same time an unexpected versatility of C(2 domains as protein-protein interaction modules, and illustrating the power of combining NMR spectroscopy and X-ray crystallography to study protein complexes.

  14. RIM-DB: a taxonomic framework for community structure analysis of methanogenic archaea from the rumen and other intestinal environments

    Directory of Open Access Journals (Sweden)

    Henning Seedorf

    2014-08-01

    Full Text Available Methane is formed by methanogenic archaea in the rumen as one of the end products of feed fermentation in the ruminant digestive tract. To develop strategies to mitigate anthropogenic methane emissions due to ruminant farming, and to understand rumen microbial differences in animal feed conversion efficiency, it is essential that methanogens can be identified and taxonomically classified with high accuracy. Currently available taxonomic frameworks offer only limited resolution beyond the genus level for taxonomic assignments of sequence data stemming from high throughput sequencing technologies. Therefore, we have developed a QIIME-compatible database (DB designed for species-level taxonomic assignment of 16S rRNA gene amplicon data targeting methanogenic archaea from the rumen, and from animal and human intestinal tracts. Called RIM-DB (Rumen and Intestinal Methanogen-DB, it contains a set of 2,379 almost full-length chimera-checked 16S rRNA gene sequences, including 20 previously unpublished sequences from isolates from three different orders. The taxonomy encompasses the recently-proposed seventh order of methanogens, the Methanomassiliicoccales, and allows differentiation between defined groups within this order. Sequence reads from rumen contents from a range of ruminant-diet combinations were taxonomically assigned using RIM-DB, Greengenes and SILVA. This comparison clearly showed that taxonomic assignments with RIM-DB resulted in the most detailed assignment, and only RIM-DB taxonomic assignments allowed methanogens to be distinguished taxonomically at the species level. RIM-DB complements the use of comprehensive databases such as Greengenes and SILVA for community structure analysis of methanogens from the rumen and other intestinal environments, and allows identification of target species for methane mitigation strategies.

  15. A Chandra Observation of the Luminous Northeastern Rim of the Galactic Supernova Remnant W28 (G6.4-0.1)

    Science.gov (United States)

    Pannuti, Thomas

    2016-06-01

    We present an analysis of a pointed observation made of the luminous northeastern rim of the Galactic supernova remnant (SNR) W28 (G6.4-0.1) with the Chandra X-ray Observatory. W28 is the archetype for the class of SNRs known as the mixed-morphology SNRs: sources in this class of objects feature a shell-like morphology with a contrasting center-filled X-ray morphology. Almost unique amongst mixed-morphology SNRs, W28 exhibits a luminous northeastern rim which is detected in the X-ray, optical and radio: this rim is also the site of a vigorous interaction between W28 and adjacent molecular clouds, as evidenced by the high concentration of hydroxyl (OH) masers seen at this rim. Our pointed Chandra observation of this rim is the highest angular X-ray observation made of this feature: initial analysis and results will be presented and discussed.

  16. Geology and MER target site characteristics along the southern rim of Isidis Planitia, Mars

    Science.gov (United States)

    Crumpler, L.S.; Tanaka, K.L.

    2003-01-01

    The southern rim of the Isidis basin contains one of the highest densities of valley networks, several restricted paleolake basins, and the stratigraphically lowest (oldest) terrain on Mars. Geologic mapping in Viking, MGS/MOC, and MOLA data, Odyssey/ THEMIS data, and other multispectral data products supports the presence of extensive fans of debris and sediments deposited along the inner rim of the Isidis basin where large valleys enter the lowlands. Additional processes subsequent to the period of intense fluvial activity, including mass flow analogous to some glacial processes, have contributed to the materials accumulated on the margins of the Isidis basin. These have occurred along preexisting channels and valleys at the termini of major channels where they enter the plains along the highland-lowland boundary. If the abundant valley networks in highland terrains are the result of runoff accompanied by saturated groundwater flow, as has been suggested in previous studies of ancient fluvial highland terrains, then the extreme age and abundance of early valley networks in the Libya Montes highland rocks should have resulted in deposition of materials that record evidence for the long-term presence of water in the form of aqueous alteration of polycrystalline constituents. The material deposited along the basin margin is likely to consist of ancient altered highland rocks in several physical states (weathered, rounded, and angular) exposing both weathered and altered surfaces, and exposures of alteration profiles in fractured faces and unweathered material from rock interiors. Debris fans shed off the southern rim of Isidis Planitia should contain materials that have experienced possible saturated groundwater flow, residence within paleolake basins, and derivative materials deposited during the most fluvially intensive part of Martian geologic history. Many of these materials have also been reworked by ice-related processes. In situ measurements of the ancient

  17. The rim zone of cement based materials - barrier or fast lane for chemical degradation?

    International Nuclear Information System (INIS)

    This contribution focuses exemplarily on the chemical and mineralogical changes in the rim zone of cement paste samples exposed to different chloride solutions (NaCl, KCl, MgCl2 and CaCl2), to hard tap water and to demineralized water. The determination of the Ca(OH)2 and Mg(OH)2 content of the solid phases was performed by means of thermogravimetry with pulverized samples (TGA/SDTA 851, Mettler-Toledo). A potential relation between temperature and the time dependant development of the material due to reactive transport processes will also be addressed. The experiments with tap water showed that the contact between the cement paste samples and hard tap water did not lead to significant changes in the composition of the solid samples or of the reaction solution. This can be attributed to a rapid formation of a protective calcium carbonate layer on the surface of the cement paste. The slight decrease of the Ca2+ content in the solution indicates that the growth of this layer occurs within the first few hours. In contrast to the tap water exposure, the results of the experiments with the MgCl2 solutions show features of an intense attack despite the presence of crystalline covering layers. The quick formation of a thick and dense Mg(OH)2 layer does not provide any protection against reactive transport processes. In this experiment, the degradation rate of Ca(OH)2 as well as the Ca2+ release was higher than in all other experiments. In addition the rapid formation of a Mg(OH)2 layer starting already during the first hour of the experiment did not prevent the chloride ingress compared to the other experiments with chloride solutions. The pH value of the reaction solution remains stable and relatively low which indicates a crystallisation process. In the other experiments, performed with demineralized water, alkali chloride solutions, and the CaCl2 solution, no significant formation of potentially protective covering layers and no development of transport inhibiting

  18. Rim-ba: Karya Tari Hasil Refleksi Kehidupan Suku Anak Dalam

    Directory of Open Access Journals (Sweden)

    Sarjiwo Sarjiwo

    2013-11-01

    Full Text Available Karya tari “Rim-ba” merupakan hasil dari refl eksi penata tari terhadap kehidupan Suku Anak Dalam (Orang Rimba di Bukit Duabelas Propinsi Jambi. Hutan yang menjadi habitat dan tempat bernaung Suku Anak Dalam semakin sempit areanya. Hal tersebut disebabkan oleh adanya penebangan liar (illegal logging maupun perluasan lahan perkebunan sawit. Tema yang diangkat dalam garapan karya tari ini adalah perjuangan hidup orang rimba. Bentuk penyajiannya simbolis representasional yang terbagi dalam empat adegan, yaitu adegan satu (introduksi tentang keterbelakangan, adegan dua tentang ritus orang rimba, adegan tiga tentang aktivitas mata pencaharian orang rimba, dan adegan empat tentang perusakan rimba. Karya tari ini didukung oleh empat orang penari. Gerak tari berorientasi pada perilaku kehidupan sehari-hari orang rimba. Musik pengiring merupakan musik hasil editing secara digital dengan software nuendo dengan memasukkan unsur suara vocal. Tata rupa pentas berdasarpada atmosfi r suasana hutan, meliputi property instalasi kayu, akar sulur gantungan dan dedaunan. Busana yangdikenakan menyerupai busana asli Suku Anak Dalam yang sudah dimodifi kasi. Sedangkan tata cahaya yangdigunakan berorientasi pada nuansa cahaya alam.Kata kunci: rimba, suku anak dalam, bukit duabelasABSTRACT“Rim-ba”: A Dance refl ecting the Life of Anak Dalam Tribe. Rimba dance is the result of the choreographer’srefl ection on the life of Anak Dalam tribe (forest people / Orang Rimba in Bukit Duabelas, Jambi province. The forestwhich is the habitat of the tribe is shrinking. This is due to the illegal logging and palm oil agriculture expansion. Thetheme of the dance is about the struggle of forest people in their life. The symbolic, choreographic representation is dividedinto four acts; the fi rst act introduces the underdeveloped condition of the people; the second act shows the rituals practiced by the forest people; the third act shows how the forest people earn their living

  19. Comparative imaging study for soft tissue changes in osteomyelitis and malignant bone tumor

    International Nuclear Information System (INIS)

    Objective: To investigate the value of the imaging findings of soft tissue abnormality in the differential diagnosis between osteomyelitis and malignant bone tumor. Methods: The CT and MRI findings of soft tissue changes in 57 cases of osteomyelitis and 70 cases of malignant bone tumor were retrospectively defined,observed, recorded and statistically analyzed. Results: In 57 cases of osteomyelitis, 54 cases were examined with CT, and soft tissue swelling was presented in 52 cases (degree I in 19 cases, degree II in 16 cases, degree III in 17 cases). Abscess-like cysts in soft tissue occurred in 6 cases, masses in 5, air in 1, fat-fluid level in 1 and sinus tract in 1. Among 14 cases examined with MR imaging, soft tissue swelling was presented in all cases (degree I in 2 cases, degree II in 6 cases and degree III in 6 cases). Abscess-like cysts appeared in 3 cases and showed high signal in diffusion weighted imaging, mass in 1 and fat-fluid level in 1. Among 54 cases examined with CT in 70 cases of malignant bone tumor, soft tissue swelling was presented in 44 cases (degree I in 29 cases, degree II in 12 cases, degree III in 3 cases). Soft tissue masses appeared in 49 cases, bone shell and shell-like calcification in 16 cases, and neoplastic bone and neoplastic calcified cartilage within soft tissue mass in 25 cases. Among 49 cases examined with MR imaging, soft tissue swelling was presented in 46 cases (degree I in 21 cases, degree II in 17 cases and degree III in 8 cases), and soft tissue masses appeared in 43 cases. The degree of soft tissue swelling and the occurrence of abscess-like cyst, mass, bone shell or shell-liked calcification in the rim of mass, neoplastic bone or neoplastic calcified cartilage in masses showed significant difference (P<0.05) between osteomyelitis group and malignant bone tumor group on CT examination. The degree of Soft tissue swelling and the occurrence frequency of abscess-like cysts and mass were significantly different (P<0

  20. How Is Bone Cancer Diagnosed?

    Science.gov (United States)

    ... with bone cancer. Accurate diagnosis of a bone tumor often depends on combining information about its location (what bone is affected and even which part of the bone is involved), appearance on x-rays, and appearance under a microscope. ...

  1. Bone mineral density test

    Science.gov (United States)

    ... Paula FJA, Black DM, Rosen CJ. Osteoporosis and bone biology.In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Textbook of Endocrinology . 13th ed. Philadelphia, ... Bone-density testing interval and transition to osteoporosis in ...

  2. Bone Graft Alternatives

    Science.gov (United States)

    ... cadavers. The types of allograft bone used for spine surgery include fresh frozen and lyophilized (freeze dried). The ... the most common uses of bone grafts in spine surgery is during spinal fusion. The use of autogenous ...

  3. Bone mineral density test

    Science.gov (United States)

    BMD test; Bone density test; Bone densitometry; DEXA scan; DXA; Dual-energy x-ray absorptiometry; p-DEXA; Osteoporosis-BMD ... need to undress. This scan is the best test to predict your risk of fractures. Peripheral DEXA ( ...

  4. Smoking and Bone Health

    Science.gov (United States)

    ... It has been called a childhood disease with old age consequences because building healthy bones in youth helps ... stronger. Weight-bearing exercise that forces you to work against gravity is the best exercise for bone. ...

  5. Bone Loss in IBD

    Science.gov (United States)

    ... DENSITY? Although bone seems as hard as a rock, it’s actually living tissue. Throughout your life, old ... available Bone Loss (.pdf) File: 290 KB 733 Third Avenue, Suite 510, New York, NY 10017 | 800- ...

  6. Bone Marrow Diseases

    Science.gov (United States)

    ... that help with blood clotting. With bone marrow disease, there are problems with the stem cells or ... marrow makes too many white blood cells Other diseases, such as lymphoma, can spread into the bone ...

  7. Building for the Pacific Rim Countries. Energy-efficient building strategies for hot, humid climates

    Energy Technology Data Exchange (ETDEWEB)

    Sheinkopf, K. [ed.

    1991-09-01

    This book has been published by the Solar Energy Industries Association (SEIA), the US trade association of the solar thermal, photovoltaic, and passive solar manufacturers, distributors, and component suppliers. Its purpose is to help architects, builders, and developers construct energy-efficient homes in hot humid climates like the Pacific Rim Countries, and to allow occupants of these homes to enjoy enhanced comfort without reliance on mechanical air-conditioning systems. Two important factors are addressed in this book. First, the past few years have seen a tremendous increase in practical applications of new research. The current popularity of ceiling paddle fans, attic radiant barriers and natural daylighting attest to the importance of keeping up with the latest concepts in energy-reduction and comfort-awareness. Professionals who have been in the field for the past few years may be unaware of the latest research findings--some of which dramatically alter prior thinking on such subjects as natural ventilation or mechanical air conditioning. The second factor is the importance of site-specific characteristics, which greatly affect building strategies and designs. A thorough understanding of the climate is a prerequisite to good building design. Such factors as temperature, humidity, wind speed and direction, and solar radiation must be understood and properly integrated into the design for the home to be truly energy-efficient.

  8. The Difference in Translaminar Pressure Gradient and Neuroretinal Rim Area in Glaucoma and Healthy Subjects

    Directory of Open Access Journals (Sweden)

    Lina Siaudvytyte

    2014-01-01

    Full Text Available Purpose. To assess differences in translaminar pressure gradient (TPG and neuroretinal rim area (NRA in patients with normal tension glaucoma (NTG, high tension glaucoma (HTG, and healthy controls. Methods. 27 patients with NTG, HTG, and healthy controls were included in the prospective pilot study (each group consisted of 9 patients. Intraocular pressure (IOP, intracranial pressure (ICP, and confocal laser scanning tomography were assessed. TPG was calculated as the difference of IOP minus ICP. ICP was measured using noninvasive two-depth transcranial Doppler device. The level of significance P 0.05. The difference between TPG for healthy (5.4(7.7 mmHg and glaucomatous eyes (NTG 6.3(3.1 mmHg, HTG 15.7(7.7 mmHg was statistically significant (P < 0.001. Higher TPG was correlated with decreased NRA (r = −0.83; P = 0.01 in the NTG group. Conclusion. Translaminar pressure gradient was higher in glaucoma patients. Reduction of NRA was related to higher TPG in NTG patients. Further prospective studies are warranted to investigate the involvement of TPG in glaucoma management.

  9. Bassoon specifically controls presynaptic P/Q-type Ca(2+) channels via RIM-binding protein.

    Science.gov (United States)

    Davydova, Daria; Marini, Claudia; King, Claire; Klueva, Julia; Bischof, Ferdinand; Romorini, Stefano; Montenegro-Venegas, Carolina; Heine, Martin; Schneider, Romy; Schröder, Markus S; Altrock, Wilko D; Henneberger, Christian; Rusakov, Dmitri A; Gundelfinger, Eckart D; Fejtova, Anna

    2014-04-01

    Voltage-dependent Ca(2+) channels (CaVs) represent the principal source of Ca(2+) ions that trigger evoked neurotransmitter release from presynaptic boutons. Ca(2+) influx is mediated mainly via CaV2.1 (P/Q-type) and CaV2.2 (N-type) channels, which differ in their properties. Their relative contribution to synaptic transmission changes during development and tunes neurotransmission during synaptic plasticity. The mechanism of differential recruitment of CaV2.1 and CaV2.2 to release sites is largely unknown. Here, we show that the presynaptic scaffolding protein Bassoon localizes specifically CaV2.1 to active zones via molecular interaction with the RIM-binding proteins (RBPs). A genetic deletion of Bassoon or an acute interference with Bassoon-RBP interaction reduces synaptic abundance of CaV2.1, weakens P/Q-type Ca(2+) current-driven synaptic transmission, and results in higher relative contribution of neurotransmission dependent on CaV2.2. These data establish Bassoon as a major regulator of the molecular composition of the presynaptic neurotransmitter release sites. PMID:24698275

  10. Collapse and expansion in the bright-rimmed cloud SFO 11NE

    CERN Document Server

    White, M A T G J

    2004-01-01

    We report the results of a search for the double-peaked blue-skewed infall signature in the bright-rimmed cloud core SFO 11NE SMM1. Observations of the optically thick HCO$^{+}$ and optically thin H$^{13}$CO$^{+}$ J=3--2 lines reveal that there is indeed a characteristic double-peaked line profile, but skewed to the red rather than the blue. Modelling of the dust continuum emission and line profiles show that the motions within SFO 11NE SMM1 are consistent with a collapsing central core surrounded by an expanding outer envelope. We show that the collapse is occurring at a similar rate to that expected onto a single solar-mass protostar and is unlikely to represent the large-scale collapse of gas onto the infrared cluster seen at the heart of SFO 11NE SMM1. The outer envelope is expanding at a much greater rate than that expected for a photoevaporated flow from the cloud surface. The modelled expansion is consistent with the bulk cloud re-expansion phase predicted by radiative-driven implosion models of cometa...

  11. Resonance Ionization Mass Spectrometry (RIMS) with Pulsed and CW-Lasers on Plutonium

    Science.gov (United States)

    Kunz, P.; Huber, G.; Passler, G.; Trautmann, N.; Wendt, K.

    2005-04-01

    The detection of long-lived plutonium isotopes in ultra-trace amounts by resonance ionization mass spectrometry (RIMS) is a well-established routine method. Detection limits of 106 to 107 atoms and precise measurements of the isotopic composition have been achieved. In this work multi-step resonance ionization of plutonium atoms has been performed with tunable lasers having very different output intensities and spectral properties. In order to compare different ways for the resonance ionization of plutonium broadband pulsed dye and titanium:sapphire lasers as well as narrow-band cw-diode and titanium:sapphire lasers have been applied for a number of efficient excitation schemes. It has been shown, that for identical excitation schemes the optical isotope selectivity can be improved by using cw-lasers (bandwidths lasers (bandwidths > 2 GHz). Pulsed and cw-laser systems have been used simultaneously for resonance ionization enabling direct comparisons of pulsed and continuous ionization processes. So far, a three-step, three-color laser excitation scheme has been proven to be most practical in terms of efficiency, selectivity and laser wavelengths. Alternatively a newly discovered three-step, two-color excitation scheme which includes a strong two-photon transition from an excited state into a high-lying autoionizing state yields similar ionization efficiencies. This two-photon transition was characterized with respect to saturation behavior and line width.

  12. Resonance Ionization Mass Spectrometry (RIMS) with Pulsed and CW-Lasers on Plutonium

    International Nuclear Information System (INIS)

    The detection of long-lived plutonium isotopes in ultra-trace amounts by resonance ionization mass spectrometry (RIMS) is a well-established routine method. Detection limits of 106 to 107 atoms and precise measurements of the isotopic composition have been achieved. In this work multi-step resonance ionization of plutonium atoms has been performed with tunable lasers having very different output intensities and spectral properties. In order to compare different ways for the resonance ionization of plutonium broadband pulsed dye and titanium:sapphire lasers as well as narrow-band cw-diode and titanium:sapphire lasers have been applied for a number of efficient excitation schemes. It has been shown, that for identical excitation schemes the optical isotope selectivity can be improved by using cw-lasers (bandwidths 2 GHz). Pulsed and cw-laser systems have been used simultaneously for resonance ionization enabling direct comparisons of pulsed and continuous ionization processes. So far, a three-step, three-color laser excitation scheme has been proven to be most practical in terms of efficiency, selectivity and laser wavelengths. Alternatively a newly discovered three-step, two-color excitation scheme which includes a strong two-photon transition from an excited state into a high-lying autoionizing state yields similar ionization efficiencies. This two-photon transition was characterized with respect to saturation behavior and line width.

  13. Radiation thermo-chemical models of protoplanetary disks I. Hydrostatic disk structure and inner rim

    CERN Document Server

    Woitke, Peter; Thi, Wing-Fai

    2009-01-01

    This paper introduces a new disk code, called ProDiMo, to calculate the thermo-chemical structure of protoplanetary disks and to interpret gas emission lines from UV to sub-mm. We combine frequency-dependent 2D dust continuum radiative transfer, kinetic gas-phase and UV photo-chemistry, ice formation, and detailed non-LTE heating & cooling balance with the consistent calculation of the hydrostatic disk structure. We include FeII and CO ro-vibrational line heating/cooling relevant for the high-density gas close to the star, and apply a modified escape probability treatment. The models are characterized by a high degree of consistency between the various physical, chemical and radiative processes, where the mutual feedbacks are solved iteratively. In application to a T Tauri disk extending from 0.5AU to 500AU, the models are featured by a puffed-up inner rim and show that the dense, shielded and cold midplane (z/r<0.1, Tg~Td) is surrounded by a layer of hot (5000K) and thin (10^7 to 10^8 cm^-3) atomic ga...

  14. Model for evolution of grain size in the rim region of high burnup UO2 fuel

    Science.gov (United States)

    Xiao, Hongxing; Long, Chongsheng; Chen, Hongsheng

    2016-04-01

    The restructuring process of the high burnup structure (HBS) formation in UO2 fuel results in sub-micron size grains that accelerate the fission gas swelling, which will raise some concern over the safety of extended the nuclear fuel operation life in the reactor. A mechanistic and engineering model for evolution of grain size in the rim region of high burnup UO2 fuel based on the experimental observations of the HBS in the literature is presented. The model takes into account dislocations evolution under irradiation and the grain subdivision occur successively at increasing local burnup. It is assumed that the original driving force for subdivision of grain in the HBS of UO2 fuel is the production and accumulation of dislocation loops during irradiation. The dislocation loops can also be annealed through thermal diffusion when the temperature is high enough. The capability of this model is validated by the comparison with the experimental data of temperature threshold of subdivision, dislocation density and sub-grain size as a function of local burnup. It is shown that the calculated results of the dislocation density and subdivided grain size as a function of local burnup are in good agreement with the experimental results.

  15. H$_2$O maser emission from bright rimmed clouds in the northern hemisphere

    CERN Document Server

    Valdettaro, R; Brand, J; Cesaroni, R

    2005-01-01

    We report the results of a multi-epoch survey of water maser observations at 22.2 GHz with the Medicina radiotelescope from 44 bright rimmed clouds (BRCs) of the northern hemisphere identified by Sugitani et al. (1989) as potential sites of star formation. The data span 16 years of observations and allow to draw conclusions about the maser detection rate in this class of objects. In spite of the relatively high far-infrared luminosities of the embedded sources ($L_{\\rm FIR}\\ga 10^2$ L$_\\odot$), H$_2$O maser emission was detected towards three globules only. Since the occurrence of water masers is higher towards bright IRAS sources, the lack of frequent H$_2$O maser emission is somewhat surprising if the suggestion of induced intermediate- and high-mass star formation within these globules is correct. The maser properties of two BRCs are characteristic of exciting sources of low-mass, while the last one (BRC~38) is consistent with an intermediate-mass object. We argue that most BRCs host young stellar objects ...

  16. Structural studies of eight bright rimmed clouds in the southern hemisphere

    CERN Document Server

    Sharma, Saurabh; Borissova, J; Ojha, D K; Ivanov, V D; Ogura, K; Kobayashi, N; Kurtev, R; Gopinathan, M; Yadav, Ram Kesh

    2016-01-01

    We carried out deep and wide-field near- and mid-infrared observations for a sample of 8 bright-rimmed clouds (BRCs). Supplemented with the $Spitzer$ archival data, we have identified and classified 44 to 433 young stellar objects (YSOs) associated with these BRCs. The Class I sources are generally located towards the places with higher extinction and are relatively closer to each other than the Class II sources, confirming that the young protostars are usually found in regions having denser molecular material. On the other hand the comparatively older population, Class II objects, are more randomly found throughout the regions, which can be due to their dynamical evolution. Using the minimal sampling tree analyses, we have extracted 13 stellar cores of 8 or more members, which contains 60\\% of the total YSOs. The typical core is $\\sim$0.6 pc in radii and somewhat elongated (aspect ratio of 1.45), of relatively low stellar density (surface density 60 pc$^{-2}$), consisting of a small (35) number of YSOs of re...

  17. Bone regeneration in dentistry

    OpenAIRE

    Tonelli, Paolo; Duvina, Marco; Barbato, Luigi; Biondi, Eleonora; Nuti, Niccolò; Brancato, Leila; Rose, Giovanna Delle

    2011-01-01

    The edentulism of the jaws and the periodontal disease represent conditions that frequently leads to disruption of the alveolar bone. The loss of the tooth and of its bone of support lead to the creation of crestal defects or situation of maxillary atrophy. The restoration of a functional condition involves the use of endosseous implants who require adequate bone volume, to deal with the masticatory load. In such situations the bone need to be regenerated, taking advantage of the biological p...

  18. BONE MECHANOTRANSDUCTION: A REVIEW

    OpenAIRE

    Reis, Joana; Capela e Silva, Fernando; Queiroga, Cristina; Lucena, Sónia; Potes, José

    2011-01-01

    This review focus on the bone physiology and mechanotransduction elements and mechanisms. Bone biology and architecture is deeply related to the mechanical environment. Orthopaedic implants cause profound changes in the biomechanics and electrophysiology of the skeleton. In the context of biomedical engineering, a deep reflexion on bone physiology and electromechanics is needed. Strategic development of new biomaterials and devices that respect and promote continuity with bone str...

  19. Gracile bone dysplasias

    Energy Technology Data Exchange (ETDEWEB)

    Kozlowski, Kazimierz [Department of Medical Imaging, The Children' s Hospital at Westmead, Locked Bag 4001, Westmead 2145, NSW (Australia); Masel, John [Department of Radiology, Royal Children' s Hospital, Brisbane (Australia); Sillence, David O. [Department of Paediatrics and Child Health, The University of Sydney (Australia); Arbuckle, Susan [Department of Anatomical Pathology, The Children' s Hospital at Westmead, NSW (Australia); Juttnerova, Vera [Oddeleni Lekarske Genetiky, Hradec Kralove (Czech Republic)

    2002-09-01

    Gracile bone dysplasias constitute a group of disorders characterised by extremely slender bones with or without fractures. We report four newborns, two of whom showed multiple fractures. Two babies had osteocraniostenosis and one had features of oligohydramnios sequence. The diagnosis in the fourth newborn, which showed thin long bones and clavicles and extremely thin, poorly ossified ribs, is uncertain. Exact diagnosis of a gracile bone dysplasia is important for genetic counselling and medico-legal reasons. (orig.)

  20. Bone cysts: unicameral and aneurysmal bone cyst.

    Science.gov (United States)

    Mascard, E; Gomez-Brouchet, A; Lambot, K

    2015-02-01

    Simple and aneurysmal bone cysts are benign lytic bone lesions, usually encountered in children and adolescents. Simple bone cyst is a cystic, fluid-filled lesion, which may be unicameral (UBC) or partially separated. UBC can involve all bones, but usually the long bone metaphysis and otherwise primarily the proximal humerus and proximal femur. The classic aneurysmal bone cyst (ABC) is an expansive and hemorrhagic tumor, usually showing characteristic translocation. About 30% of ABCs are secondary, without translocation; they occur in reaction to another, usually benign, bone lesion. ABCs are metaphyseal, excentric, bulging, fluid-filled and multicameral, and may develop in all bones of the skeleton. On MRI, the fluid level is evocative. It is mandatory to distinguish ABC from UBC, as prognosis and treatment are different. UBCs resolve spontaneously between adolescence and adulthood; the main concern is the risk of pathologic fracture. Treatment in non-threatening forms consists in intracystic injection of methylprednisolone. When there is a risk of fracture, especially of the femoral neck, surgery with curettage, filling with bone substitute or graft and osteosynthesis may be required. ABCs are potentially more aggressive, with a risk of bone destruction. Diagnosis must systematically be confirmed by biopsy, identifying soft-tissue parts, as telangiectatic sarcoma can mimic ABC. Intra-lesional sclerotherapy with alcohol is an effective treatment. In spinal ABC and in aggressive lesions with a risk of fracture, surgical treatment should be preferred, possibly after preoperative embolization. The risk of malignant transformation is very low, except in case of radiation therapy. PMID:25579825

  1. Enzymatic maceration of bone

    DEFF Research Database (Denmark)

    Uhre, Marie-Louise; Eriksen, Anne Marie; Simonsen, Kim Pilkjær;

    2015-01-01

    the bones. The DNA analysis showed that DNA was preserved on all the pieces of bones which were examined. Finally, the investigation suggests that enzyme maceration could be gentler on the bones, as the edges appeared less frayed. The enzyme maceration was also a quicker method; it took three hours compared...

  2. What's a Funny Bone?

    Science.gov (United States)

    ... Help White House Lunch Recipes What's a Funny Bone? KidsHealth > For Kids > What's a Funny Bone? Print A A A Text Size Have you ... prickly kind of dull pain? That's your funny bone! It doesn't really hurt as much as ...

  3. Menopause and Bone Loss

    Science.gov (United States)

    Fact Sheet & Menopause Bone Loss How are bone loss and menopause related? Throughout life your body keeps a balance between the loss ... The sooner you take steps to prevent bone loss, the lower your risk of osteoporosis later in life. If you are skipping menstrual periods, have had ...

  4. Er,Cr:YSGG 激光对老年人非龋性硬化牙本质粘结强度的影响%Effect of Er,Cr:YSGG laser on the Bonding strength of the elderly non-carious sclerotic dentin

    Institute of Scientific and Technical Information of China (English)

    刘艳; 付强; 葛志华; 贾兴亚

    2014-01-01

    AIM:To evaluate the effect of Er , Cr:YSGG laser preparation on the bonding properties be-tween composite resin and the the sclerotic dentin of elderly subjects .METHODS:40 extracted premolars with cervi-cal wedge-shaped defect and sclerotic dentin on the surface from 60~70 year-old people were randomly divided into 2 groups (n=20).In the experimental group Er,Cr:YSGG laser was used for cavity preparation , in the control group regular burs with high-speed turbines was used for cavity preparation .The cavies of all teeth were filled with composite resin Filtek Z350.15 samples in each group were cut into dumbbell-shaped specimens with a bonding area of 1 mm2 . The micro-tensile bond strength (MBS) was tested on Instron 5848 Micro Tester.Each tooth of the remaining 5 sam-ples in each groupe were divided into two parts along buccolingual directions parallel to the long axis of the tooth .The bonding interface was observed by SEM .RESULTS: The MBS ( MPa ) of experimental and control groups was (35.24 ±7.05)MPa and(27.56 ±4.79)MPa respectively(P<0.05).SEM observation showed that hybrid layer be-tween sclerotic dentin and composite resin was thinner in experimental group , resin tags, and crystallizing column with-in dentinal tubules connected together tightly .CONCLUSION:Er,Cr:YSGG laser preparation can improve the bond strength between elderly non-carious sclerotic dentin and composite resin .%目的:评价Er,Cr:YSGG激光备洞对离体牙楔形缺损处非龋性硬化牙本质与复合树脂间粘结性能的影响。方法:选取40个颊侧颈部有楔形缺损的老年人(60~70岁)前磨牙,随机分2组(n=20),分别用Er,Cr:YSGG激光(实验组)和高速涡轮牙钻(对照组)备洞后,用复合树脂Filtek Z350进行充填;然后每组各取15个样本制备成粘结面积约为1 mm ×1 mm的哑铃形片状试件,用Instron 5848微力试验机测定其微拉伸粘结强度( MBS);每组剩余的另5个样本分别

  5. SADRŽAJ IZVJEŠĆA SENJSKO-MODRUŠKIH BISKUPA U RIM OD 1602. DO 1919. GODINE

    OpenAIRE

    BOGOVIĆ, MILE

    1996-01-01

    U radu se donosi sadržaj izvješća senjsko-modruških biskupa u Rim od 1602. do 1919. Novija izvješća nisu u Tajnom vatikanskom arhivu dostupna istraživačima. Izvješća se nalaze u fondu Relationes ad limina voli. 734 i 799. Autor navodi imena znanstvenika koji su se bavili tom problematikom, imena biskupa koji su ta izvješća slali u Rim kao i njihov sadržaj na temelju kojega dobivamo detaljne i vrijedne podatke o stanju na području senjsko-modruške biskupije u tom razdoblju. Po njegovu mišljenj...

  6. Catastrophic erosion of Hellas basin rim on Mars induced by magmatic intrusion into volatile-rich rocks

    Science.gov (United States)

    Tanaka, K.L.; Kargel, J.S.; MacKinnon, D.J.; Hare, T.M.; Hoffman, N.

    2002-01-01

    Malea and Hesperia Plana form large sectors of the rim of Hellas basin that display partly eroded volcanic shields and plains. These regions have topographic profiles that appear to be several hundred meters lower than those of adjacent rim sectors and lack prominent massifs of remnant basement that would be expected to stand above the lava plains. We interpret that before the volcanic edifices were constructed, these regions were denuded by an early stage of voluminous sill intrusion into friable, volatile-rich impact breccia. Magma-volatile interactions may have resulted in catastrophic generation of debris flows deposited into the adjacent basin, particularly if CO2 were involved. Later, lavas covered the eroded terrain; in turn, the lavas were eroded locally by volatile interactions. Across Mars, huge channel systems, erosional features in volcanic terranes, and vast layered deposits may be due to magma-volatile interactions.

  7. Moldes protótipos para a produção de peças em RIM

    OpenAIRE

    Silva, Marta Flora Araújo

    2008-01-01

    Dissertação de mestrado em Projecto e Fabrico de Moldes O presente relatório reporta a tese de mestrado, desenvolvida no âmbito do mestrado em Projecto e Fabrico de Moldes do Departamento de Engenharia de Polímeros da Universidade do Minho e tem como estudo central o desenvolvimento de moldes protótipos para a produção de peças em RIM. O tema da referida tese está não só relacionado com o mestrado em questão mas também surge no âmbito do desenvolvimento do projecto PerRIM. O...

  8. Matsu Cultural Heritage and Its Conservation in Bohai Rim - Case Study on the Hall of Fujian in Yantai

    Science.gov (United States)

    Yao, S.

    2015-08-01

    Since the Yuan Dynasty, the belief of Matsu had started to spread from the birthplace to the northern coastal areas in China. Matsu worship developed to the pinnacle with the official promotion on account of the government's dependence on grain transported by sea since the mid-Qing Dynasty. A large amount of Matsu temples emerged in coastal cities of Bohai Rim where it still keeps a large number of them until now. It has much relationship between the spread of Matsu culture and the flow of Fujian population. It was one of the main building way that the Matsu temples attached to the local hall of Fujian in Bohai Rim. The Hall of Fujian in Yantai, Which was built with materials taken from Fujian, in the feature of traditional architectural style from QuanZhou, is very different from the local building style of Yantai. This case indicates that maritime culture of the south area had spread and developed in the north areas under the promotion of the population flow and the economic transaction. The essay introduces briefly about the development of Matsu culture in Bohai Rim and takes the case study of the Hall of Fujian in Yantai analyzing its causes and features, and the value as Matsu heritage. Then the paper will discuss the conservation of Matsu culture mere include the tangible and the intangible culture heritage around the origin area, the heritages of the spread area also have the same importance significance. With the evolution of the society, it calls urgent attention and protection of Matsu culture in Bohai Rim.

  9. A STUDY ON PREVALENCE OF DEPRESSION IN ATTEMPTED SUICIDE PATIENTS ATTENDING R.I.M.S . HOSPITAL, IMPHAL

    OpenAIRE

    Hemchand Singh; Nirendrakumar Singh; Rameshwore Y

    2014-01-01

    OBJECTIVE: To evaluate prevalence of depression in individuals who attempted suicide and attended Regional Institute of Medical Sciences Hospital , Imphal. Method: The study was cross - sectional in which 50 patients who attempted suicide and attend ed RIMS Hospital and fulfilled the inclusion criteria were included in the study which was conducted from November 2005 to October 2006. A semi - structured interview schedule was used to find out the socio - ...

  10. Genetic enhancement of cognition in a kindred with cone-rod dystrophy due to RIMS1 mutation

    OpenAIRE

    Sisodiya, S.M.; Thompson, P J; Need, A.; Harris, S.E.; M.E. Weale; Wilkie, S. E.; Michaelides, M.; Free, S.L.; Walley, N; Gumbs, C.; Gerrelli, D.; Ruddle, P.; Whalley, L.J.; Starr, J M; Hunt, D M

    2007-01-01

    Background: The genetic basis of variation in human cognitive abilities is poorly understood. RIMS1 encodes a synapse active- zone protein with important roles in the maintenance of normal synaptic function: mice lacking this protein have greatly reduced learning ability and memory function.Objective: An established paradigm examining the structural and functional effects of mutations in genes expressed in the eye and the brain was used to study a kindred with an inherited retinal dystrophy d...

  11. Initial Results of an Acetabular Center Axis Registration Technique in Navigated Hip Arthroplasty with Deformed Acetabular Rims

    OpenAIRE

    Wada, Hiroshi; Mishima, Hajime; Yoshizawa, Tomohiro; Sugaya, Hisashi; Nishino, Tomofumi; Yamazaki, Masashi

    2016-01-01

    Background In cementless total hip arthroplasty, imageless computer-assisted navigation is usually used to register the anterior pelvic plane (APP). The accuracy of this method is influenced by the subcutaneous tissues overlying the registration landmarks. On the other hand, the acetabular center axis (ACA) is determined from the acetabular rim. Precise registration of the ACA is possible because of direct palpation using a pointer. Imageless navigation using the ACA usually targets patients ...

  12. Combination of surgical excision and custom designed silicon pressure splint therapy for keloids on the helical rim

    Directory of Open Access Journals (Sweden)

    Altmeyer Peter

    2007-03-01

    Full Text Available Abstract Keloids are defined as dermal fibrotic lesions which are considered an aberration of the wound healing process. Their etiology and pathogenesis are poorly understood. Different treatment modalities are described in the literature depending on the morphology and size of the keloid. We report a case of a large ear keloid on the helical rim which was successfully treated with surgery and a custom designed silicon pressure clip.

  13. Tin in Human Bones

    OpenAIRE

    Jambor, Jaroslav; Smreka, Vâclav

    1993-01-01

    TIN IN HUMAN BONES. The tin content in the bones of 149 skeletons from the 1st - 5th centuries A.D., and of 11 individuals of the recent population was determined. The bone samples were carbonized and analyzed through emission spectroscopy with a.c. excitation. The tin content in bones of recent populations not exposed to extra tin supply is about one order of magnitude higher than is the case with the bones od some populations that lived at the beginning of our era. The distribut...

  14. Bone regeneration with cultured human bone grafts

    Energy Technology Data Exchange (ETDEWEB)

    Yoshikawa, T.; Nakajima, H. [Nara Medical Univ., Kashihara City (Japan). Dept. of Pathology; Nara Medical Univ., Kashihara City (Japan). Dept. of Orthopedic Surgery; Ohgushi, H.; Ueda, Y.; Takakura, Y. [Nara Medical Univ., Kashihara City (Japan). Dept. of Orthopedic Surgery; Uemura, T.; Tateishi, T. [National Inst. for Advanced Interdisciplinary Research (NAIR), Ibaraki (Japan). Tsukuba Research Center; Enomoto, Y.; Ichijima, K. [Nara Medical Univ., Kashihara City (Japan). Dept. of Pathology

    2001-07-01

    From 73 year old female patient, 3 ml of bone marrow was collected from the ilium. The marrow was cultured to concentrate and expand the marrow mesenchymal cells on a culture dish. The cultured cells were then subculturedeither on another culture dish or in porous areas of hydroxyapatite ceramics in the presence of dexamethasone and beta-glycerophosphate (osteo genic medium). The subculturedtissues on the dishes were analyzed by scanning electron microscopy (SEM), and subculturedtissues in the ceramics were implanted intraperitoneally into athymic nude mice. Vigorous growth of spindle-shaped cells and a marked formation of bone matrix beneath the cell layers was observed on the subculture dishes by SEM. The intraperitoneally implanted ceramics with cultured tissues revealed thick layer of lamellar bone together with active osteoblasts lining in many pore areas of the ceramics after 8 weeks. The in vitro bone formations on the culture dishes and in vivo bone formation in porous ceramics were detected. These results indicate that we can assemble an in vitro bone/ceramic construct, and due to the porous framework of the ceramic, the construct has osteogenic potential similar to that of autologous cancellous bone. A significant benefit of this method is that the construct can be made with only a small amount of aspirated marrow cells from aged patients with little host morbidity. (orig.)

  15. Study of a bright-rimmed cloud at the border of the infrared dust bubble CN20

    Science.gov (United States)

    Ortega, M. E.; Giacani, E.; Paron, S.; Rubio, M.

    2016-06-01

    We characterize an uncatalogued bright-rimmed cloud located at the border of the infrared dust bubble CN20 with the aim of investigating triggered star formation. In order to do this, we carried out radio continuum observations at 8.9 GHz using the Jansky Very Large Array (JVLA) interferometer with a synthesized beam size of 13 arcsec × 5 arcsec, and molecular observations using the Atacama Submillimeter Telescope Experiment (ASTE) at the 13CO J = 3-2 and CS J = 7-6 transitions. An analysis of the molecular observations and of Herschel public data revealed the presence of a warm and dense clump with Tdust ˜ 25 K and n(H2) ˜ 3 × 105 cm-3. The high angular resolution and sensitivity of the new radio continuum data revealed an arc-like radio filament in excellent correspondence with the illuminated border of the bright-rimmed cloud. This ionized boundary layer has an electron density of 176 cm-3. The spatial distribution of the young stellar object candidates probably related to the bright-rimmed cloud does not show clear evidence of a triggered origin. Finally, based on the evaluation of the pressure balance between the ionized and molecular gas, we conclude that the ionization front has stalled at the surface of the clump.

  16. Challenges, solutions, and best practices in telemental health service delivery across the pacific rim-a summary.

    Science.gov (United States)

    Doarn, Charles R; Shore, Jay; Ferguson, Stewart; Jordan, Patricia J; Saiki, Stanley; Poropatich, Ronald K

    2012-10-01

    The Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, in conjunction with the American Telemedicine Association's Annual Mid-Year Meeting, conducted a 1-day workshop on how maturing and emerging processes and applications in the field of telemental health (TMH) can be expanded to enhance access to behavioral health services in the Pacific Rim. The purpose of the workshop was to bring together experts in the field of TMH from the military, federal agencies, academia, and regional healthcare organizations serving populations in the Pacific Rim. The workshop reviewed current technologies and systems to better understand their current and potential applications to regional challenges, including the Department of Defense and other federal organizations. The meeting was attended by approximately 100 participants, representing military, government, academia, healthcare centers, and tribal organizations. It was organized into four sessions focusing on the following topic areas: (1) Remote Screening and Assessment; (2) Post-Deployment Adjustment Mental Health Treatment; (3) Suicide Prevention and Management; and (4) Delivery of Training, Education, and Mental Health Work Force Development. The meeting's goal was to discuss challenges, gaps, and collaborative opportunities in this area to enhance existing or create new opportunities for collaborations in the delivery of TMH services to the populations of the Pacific Rim. A set of recommendations for collaboration are presented.

  17. The Rim101p/PacC pathway and alkaline pH regulate pattern formation in yeast colonies.

    Science.gov (United States)

    Piccirillo, Sarah; White, Melissa G; Murphy, Jeffrey C; Law, Douglas J; Honigberg, Saul M

    2010-03-01

    Multicellular organisms utilize cell-to-cell signals to build patterns of cell types within embryos, but the ability of fungi to form organized communities has been largely unexplored. Here we report that colonies of the yeast Saccharomyces cerevisiae formed sharply divided layers of sporulating and nonsporulating cells. Sporulation initiated in the colony's interior, and this region expanded upward as the colony matured. Two key activators of sporulation, IME1 and IME2, were initially transcribed in overlapping regions of the colony, and this overlap corresponded to the initial sporulation region. The development of colony sporulation patterns depended on cell-to-cell signals, as demonstrated by chimeric colonies, which contain a mixture of two strains. One such signal is alkaline pH, mediated through the Rim101p/PacC pathway. Meiotic-arrest mutants that increased alkali production stimulated expression of an early meiotic gene in neighboring cells, whereas a mutant that decreased alkali production (cit1Delta) decreased this expression. Addition of alkali to colonies accelerated the expansion of the interior region of sporulation, whereas inactivation of the Rim101p pathway inhibited this expansion. Thus, the Rim101 pathway mediates colony patterning by responding to cell-to-cell pH signals. Cell-to-cell signals coupled with nutrient gradients may allow efficient spore formation and spore dispersal in natural environments. PMID:20038633

  18. Radiation thermo-chemical models of protoplanetary discs. III. Impact of inner rims on Spectral Energy Distributions

    CERN Document Server

    Thi, Wing-Fai; Kamp, Inga

    2010-01-01

    We study the hydrostatic density structure of the inner disc rim around HerbigAe stars using the thermo-chemical hydrostatic code ProDiMo. We compare the Spectral Energy Distributions (SEDs) and images from our hydrostatic disc models to that from prescribed density structure discs. The 2D continuum radiative transfer in ProDiMo includes isotropic scattering. The dust temperature is set by the condition of radiative equilibrium. In the thermal-decoupled case the gas temperature is governed by the balance between various heating and cooling processes. The gas and dust interact thermally via photoelectrons, radiatively, and via gas accommodation on grain surfaces. As a result, the gas is much hotter than in the thermo-coupled case, where the gas and dust temperatures are equal, reaching a few thousands K in the upper disc layers and making the inner rim higher. A physically motivated density drop at the inner radius ("soft-edge") results in rounded inner rims, which appear ring-like in near-infrared images. The...

  19. Star formation in bright-rimmed clouds and cluster associated with W5 E H{\\sc ii} region

    CERN Document Server

    Chauhan, Neelam; Ogura, K; Jose, J; Ojha, D K; Samal, M R; Mito, H

    2011-01-01

    The aim of this paper is to present the results of photometric investigations of the central cluster of the W5 E region as well as a follow-up study of the triggered star formation in and around bright-rimmed clouds (BRCs). We have carried out wide field $UBVI_c$ and deep $VI_c$ photometry of the W5 E H{\\sc ii} region. A distance of $\\sim$2.1 kpc and a mean age of $\\sim$1.3 Myr have been obtained for the central cluster. The young stellar objects (YSOs) associated with the region are identified on the basis of near-infrared and mid-infrared observations. We confirmed our earlier results that the average age of the YSOs lying on/inside the rim are younger than those lying outside the rim. The global distribution of the YSOs shows an aligned distribution from the ionising source to the BRCs. These facts indicate that a series of radiation driven implosion processes proceeded from near the central ionising source towards the periphery of the W5 E H{\\sc ii} region. We found that, in general, the age distributions...

  20. The spatial-temporal evolution of aerosol optical depth and the analysis of influence factors in Bohai Rim

    International Nuclear Information System (INIS)

    Aerosol Optical Depth (AOD) is an important parameter of aerosol optical properties and it is an important physical parameter quantity to understanding the atmospheric environment. Bohai Rim is one of the three major urban agglomeration regions with rapidly developing economy in China. The study of AOD over this region is important to understand the environment and climate in Bohai Rim. Firstly, aerosol product data from 2000 to 2010, published by NASA, were used to analyze the temporal-spatial evolution of AOD in Bohai Rim with precision evaluation. The results showed that the spatial distribution of AOD had an obvious regional characteristic. The spatial distribution characterized that a much high value existed at urban areas and plain areas. On the contrary, the low value data existed in some mountainous regions which had higher percentages of forest coverage. The AOD values fluctuated somewhat each year in the region, from the minimum annual mean in 2003 to the maximum in 2009. Generally, the highest AOD value was in summer, followed by spring, autumn and winter. In terms of monthly variation, the value of AOD reached its peak in June and the lowest value was in December. This study analyzed the relation between AOD and some influence factors such as land use types, elevation, and distribution of urban agglomeration and so on. These results provide an important basic dataset for climate and environmental research

  1. RIM15 antagonistic pleiotropy is responsible for differences in fermentation and stress response kinetics in budding yeast.

    Science.gov (United States)

    Kessi-Pérez, Eduardo I; Araos, Sebastián; García, Verónica; Salinas, Francisco; Abarca, Valentina; Larrondo, Luis F; Martínez, Claudio; Cubillos, Francisco A

    2016-05-01

    Different natural yeast populations have faced dissimilar selective pressures due to the heterogeneous fermentation substrates available around the world; this increases the genetic and phenotypic diversity in Saccharomyces cerevisiae In this context, we expect prominent differences between isolates when exposed to a particular condition, such as wine or sake musts. To better comprehend the mechanisms underlying niche adaptation between two S. cerevisiae isolates obtained from wine and sake fermentation processes, we evaluated fermentative and fungicide resistance phenotypes and identify the molecular origin of such adaptive variation. Multiple regions were associated with fermentation rate under different nitrogen conditions and fungicide resistance, with a single QTL co-localizing in all traits. Analysis around this region identified RIM15 as the causative locus driving fungicide sensitivity, together with efficient nitrogen utilization and glycerol production in the wine strain. A null RIM15 variant confers a greater fermentation rate through the utilization of available glucose instead of its storage. However, this variant has a detrimental effect on fungicide resistance since complex sugars are not synthesized and transported into the membrane. Together, our results reveal the antagonist pleiotropic nature of a RIM15 null variant, positively affecting a series of fermentation related phenotypes, but apparently detrimental in the wild. PMID:26945894

  2. Bone scintiscanning updated.

    Science.gov (United States)

    Lentle, B C; Russell, A S; Percy, J S; Scott, J R; Jackson, F I

    1976-03-01

    Use of modern materials and methods has given bone scintiscanning a larger role in clinical medicine, The safety and ready availability of newer agents have led to its greater use in investigating both benign and malignant disease of bone and joint. Present evidence suggests that abnormal accumulation of 99mTc-polyphosphate and its analogues results from ionic deposition at crystal surfaces in immature bone, this process being facilitated by an increase in bone vascularity. There is, also, a component of matrix localization. These factors are in keeping with the concept that abnormal scintiscan sites represent areas of increased osteoblastic activity, although this may be an oversimplification. Increasing evidence shows that the bone scintiscan is more sensitive than conventional radiography in detecting focal disease of bone, and its ability to reflect the immediate status of bone further complements radiographic findings. The main limitation of this method relates to nonspecificity of the results obtained.

  3. FIRST CALL FOR PAPERS The Second IEEE Pacific-Rim Conference on Multimedia

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Oct. 24~26, 2001, Beijing, China http://research.microsoft.com/~PCM2001. IEEE Signal Processing Society, IEEE Circuits and Systems Society National Science Foundation of China IEEE China, Electronics Society Of China, China Society of Electronics China Society of Computers, China Society of Image and Graphics   The second IEEE Pacific-Rim Conference on Multimedia will be held in Beijing in the next “golden autumn”. Beijing has been the culture capital of Chinese for near one thousand years with many historical palaces, magnificent museums and beautiful parks, as well as rich culture activities. In the last decade, Beijing has also witnessed spectacular growth of hi-tech industry, especially in the Internet and multimedia applications areas. The conference site, Zhongguangchun, known as China's Silicon Valley, is the national center of research, development and education with hundreds of universities and research institutions, and many successful companies providing both multimedia content and systems expertise. The conference complements this wonderful setting by providing a forum to presenting and exploring technological and artistic advancements in multimedia. Technical issues, theory and practice, artistic and consumer innovations will bring together researchers, artists, developers, educators, performers, and practitioners of multimedia from Pacific-Rim and the world. Present your work at PCM2001 and define the future of multimedia in the next millennium!   The technical program will feature keynote addresses, tutorials, special sessions, panels, technical demonstrations, in addition to technical presentations of refereed papers. We cordially invite you to submit your work in one or more of about forms for, but not limited to, the following three areas:   Multimedia processing and coding, including multimedia processing and compression, content analysis, content-based retrieval, watermarking and security;   Multimedia system support and

  4. Initial Pancam Visible/Near-infrared Observations of Materials near Endeavour Crater's Western Rim

    Science.gov (United States)

    Johnson, J. R.; Bell, J. F.; Farrand, W. H.; Wang, A.; MER Athena Science Team

    2011-12-01

    The Pancam multispectral stereo camera on the Opportunity Mars Exploration Rover began acquiring visible/near-infrared (443-1009 nm) images of materials along the western edge of Endeavour Crater in August, 2011. Preliminary observations documented changes in the color and textures of rocks and soils during the transition from typical Meridiani plains to the Endeavour rim area. As the rover approached Cape York and Spirit Point, Pancam observations (along with those from the Microscopic Imager) documented changes in size distributions of the ubiquitous hematite-rich spherules. For example, preliminary observations near the outcrop "Gibraltar" (north of the sand-filled 35 m diameter crater "Pathfinder") showed spherules embedded in the outcrop to be 5 mm (Figure 1). At the time of this writing, not all Pancam images of the Gibraltar area had been transmitted to the ground, but reflectance spectra from these observations will be presented at the meeting. Comparison of Pancam reflectance spectra to CRISM observations of the region also demonstrate the utility of orbital imaging spectroscopy as a means to guide rover traverses around Spirit Point during investigations of phyllosilicates-bearing materials. While Fe-bearing oxides and oxyhydroxides can exhibit distinctive spectral features in the visible/near-infrared, most diagnostic spectral features of phyllosilicate minerals are outside the spectral range of Pancam. Nonetheless, the potential exists for using Pancam for phyllosilicate-bearing rock detections, although they will be non-unique. For example, different classes of phyllosilicates (e.g., nontronite, montmorillonite) can be grouped to first order based on spectral parameters such as 900 nm band depth or reflectance maximum position vs. 535 nm band depth. Pancam observations relevant to these detections will be presented at the meeting.

  5. Ciclamato de sódio e rim fetal Sodium cyclamate and fetal kidney

    Directory of Open Access Journals (Sweden)

    José Germano Ferraz de Arruda

    2003-06-01

    Full Text Available O ciclamato é usado como adoçante artificial não calórico em diversos alimentos e bebidas, sendo 30 vezes mais doce que a sacarose sem o sabor amargo da sacarina. Aparece na composição dos produtos como ciclamato de sódio, ciclamato de cálcio e ácido ciclâmico. O ciclamato e a ciclohexilamina, seu principal metabólito, atravessam a barreira placentária em humanos e desse modo podem ser expostos ao feto. O rim de ratos pode ser afetado por elevadas doses de ciclamato de sódio. Estudos sobre efeitos do ciclamato de sódio na espécie humana são necessários, pois, além de poder substituir a sacarose - prejudicial em casos de diabetes ou quando o controle e a redução do peso corporal são essenciais para a saúde dos pacientes - não propicia desenvolvimento de cárie dentária.Cyclamate is used as an artificial non-caloric sweetener in a variety of foods and beverages, being 30 times as sweet as sugar without the bitter after-taste of saccharin. It is present in the formula of products such as sodium and calcium cyclamates and cyclamic acid. Cyclamate and cyclohexylamine, its principal metabolite, can cross the human placenta exposing the fetus. It has been demonstrated in rats that the kidney may be adversely affected by high doses of cyclamate. Studies on the effects of sodium cyclamate in the human species are necessary, because in addition to replacing saccharose - harmful in individuals with diabetes or patients in whom weight reduction and control are essential for health - it does not cause dental caries.

  6. Correlation between 3D microstructural and 2D histomorphometric properties of subchondral bone with healthy and degenerative cartilage of the knee joint.

    Science.gov (United States)

    Lahm, Andreas; Kasch, Richard; Spank, Heiko; Erggelet, Christoph; Esser, Jan; Merk, Harry; Mrosek, Eike

    2014-11-01

    Cartilage degeneration of the knee joint is considered to be a largely mechanically driven process. We conducted a microstructural and histomorphometric analysis of subchondral bone samples of intact cartilage and in samples with early and higher- grade arthritic degeneration to compare the different states and correlate the findings with the condition of hyaline cartilage. These findings will enable us to evaluate changes in biomechanical properties of subchondral bone during the evolution of arthritic degeneration, for which bone density alone is an insufficient parameter. From a continuous series of 80 patients undergoing implantation of total knee endoprosthesis 30 osteochondral samples with lesions macroscopically classified as ICRS grade 1b (group A) and 30 samples with ICRS grade 3a or 3b lesions (group B) were taken. The bone samples were assessed by 2D histomorphometry (semiautomatic image analysis system) and 3D microstructural analysis (high-resolution micro-CT system). The cartilage was examined using the semiquantitative real-time PCR gene expression of collagen type I and II and aggrecan. Both histomorphometry and microstructural and biomechanical analysis of subchondral bone in groups A and B consistently revealed progressive changes of both bone and cartilage compared with healthy controls. The severity of cartilage degeneration as assessed by RT PCR was significantly correlated with BV/TV (Bone Volume Fraction), Tb.Th (Trabecular Thickness) showed a slight increase. Tb.N (Trabecular Number), Tb.Sp (Trabecular separation) SMI (Structure Model Index), Conn.D (Connectivity Density) and DA (Degree of Anisotropy) were inversely correlated. We saw sclerotic transformation and phagocytic reticulum cells. Bone volume fraction decreased with an increasing distance from the cartilage with the differences compared with healthy controls becoming greater in more advanced cartilage damage. The density of subchondral bone alone is considered an unreliable

  7. CHRONIC OTITIS MEDIA: HIGH RESOLUTION COMPUTED TOMOGRAPHIC EVALUATION OF THE TEMPORAL BONE WITH SURGICAL CORRELATION

    Directory of Open Access Journals (Sweden)

    Chakenahalli P.

    2016-05-01

    Full Text Available PURPOSE To correlate the sensitivity and specificity of High Resolution Computed Tomography (HRCT findings of temporal bone in chronic otitis media with surgical findings. MATERIALS & METHODS HRCT of temporal bone of fifty patients with chronic otitis media were evaluated prospectively between July 2012 and December 2013. The various pathological findings, complications and important anatomical variations were evaluated. These findings were compared with intraoperative findings. Statistical methods were carried out using SPSS for Windows (Version 16.0 and Minitab (Version 11.0 for windows. The sensitivity, specificity, false positive and false negative rates were calculated. The level of significance was considered significant for P-values <0.05. RESULTS HRCT is reliable for all the parameters like scutum erosion, ossicular erosion, mastoid pneumatisation, low lying dura, anterior lying sigmoid, Korner’s septum, cholesteatoma extension in middle ear and mastoid, and presence of complications like mastoiditis, mastoid abscess, mastoid cortex dehiscence, sigmoid sinus plate erosion, facial canal dehiscence, tegmen mastoideum erosion, labyrinthine fistula and intracranial complications with a P value <0.05 but not reliable for tegmen tympani erosion and posterior fossa dural plate erosion. Among the findings related to adjacent neurovascular structures, facial canal dehiscence was commonest followed by anterior lying sigmoid sinus and low lying dura. In ossicular erosion, incus was most commonly involved followed by stapes and malleus. Most of the mastoid in this study was sclerotic followed by pneumatised and diploic. The epitympanum and mastoid antrum were the most commonly involved areas in cholesteatoma followed by aditus, mastoid air cells, posterior tympanum, mesotympanum, hypotympanum, protympanum and perilabyrinthine air cells in decreasing order of frequency. CONCLUSIONS HRCT temporal bone is a reliable investigation in preoperative

  8. Accuracy evaluation of a new three-dimensional reproduction method of edentulous dental casts, and wax occlusion rims with jaw relation

    OpenAIRE

    Yuan, Fu-Song; Sun, Yu-Chun; Wang, Yong; Lü, Pei-Jun

    2013-01-01

    The article introduces a new method for three-dimensional reproduction of edentulous dental casts, and wax occlusion rims with jaw relation by using a commercial high-speed line laser scanner and reverse engineering software and evaluates the method's accuracy in vitro. The method comprises three main steps: (i) acquisition of the three-dimensional stereolithography data of maxillary and mandibular edentulous dental casts and wax occlusion rims; (ii) acquisition of the three-dimensional stere...

  9. Effect of power-assisted hand-rim wheelchair propulsion on shoulder load in experienced wheelchair users: A pilot study with an instrumented wheelchair.

    Science.gov (United States)

    Kloosterman, Marieke G M; Buurke, Jaap H; de Vries, Wiebe; Van der Woude, Lucas H V; Rietman, Johan S

    2015-10-01

    This study aims to compare hand-rim and power-assisted hand-rim propulsion on potential risk factors for shoulder overuse injuries: intensity and repetition of shoulder loading and force generation in the extremes of shoulder motion. Eleven experienced hand-rim wheelchair users propelled an instrumented wheelchair on a treadmill while upper-extremity kinematic, kinetic and surface electromyographical data was collected during propulsion with and without power-assist. As a result during power-assisted propulsion the peak resultant force exerted at the hand-rim decreased and was performed with significantly less abduction and internal rotation at the shoulder. At shoulder level the anterior directed force and internal rotation and flexion moments decreased significantly. In addition, posterior and the minimal inferior directed forces and the external rotation moment significantly increased. The stroke angle decreased significantly, as did maximum shoulder flexion, extension, abduction and internal rotation. Stroke-frequency significantly increased. Muscle activation in the anterior deltoid and pectoralis major also decreased significantly. In conclusion, compared to hand-rim propulsion power-assisted propulsion seems effective in reducing potential risk factors of overuse injuries with the highest gain on decreased range of motion of the shoulder joint, lower peak propulsion force on the rim and reduced muscle activity. PMID:26307457

  10. Biophotonics and Bone Biology

    Science.gov (United States)

    Zimmerli, Gregory; Fischer, David; Asipauskas, Marius; Chauhan, Chirag; Compitello, Nicole; Burke, Jamie; Tate, Melissa Knothe

    2004-01-01

    One of the more-serious side effects of extended space flight is an accelerated bone loss [Bioastronautics Critical Path Roadmap, http://research.hq.nasa.gov/code_u/bcpr/index.cfm]. Rates of bone loss are highest in the weight-bearing bones of the hip and spine regions, and the average rate of bone loss as measured by bone mineral density measurements is around 1.2% per month for persons in a microgravity environment. It shows that an extrapolation of the microgravity induced bone loss rates to longer time scales, such as a 2.5 year round-trip to Mars (6 months out at 0 g, 1.5 year stay on Mars at 0.38 g, 6 months back at 0 g), could severely compromise the skeletal system of such a person.

  11. Bone tumors: Nursing care

    International Nuclear Information System (INIS)

    Bone tumors represent approximately 5% of childhood malignancies. osteosarcoma is the primary malignant bone tumor, accounting for 60% of cancer with peak incidence in the 2nd decade of life. Ewing's sarcoma is the second most common bone cancer with peak at a slightly younger age. This presentation discusses similarities and differences in the diagnosis and treatment of these two malignancies. Diagnostic procedures include plain radiographs, CT and MRI of the primary site, plain x-ray and CT of the chest, bone scan, and biopsy of the primary tumor. For patients diagnosed with Ewing's sarcoma, a bone marrow aspirate and biopsy will also be required. Our current approach to the treatment of bone tumors includes preoperative combination chemotherapy and en bloc surgical removal of the tumor followed by postoperative chemotherapy. In the case of Ewing's sarcoma, radiation therapy may be employed in addition to surgery, if margins are questionable of instead of surgery, if the tumor is not resectable

  12. Computed tomographical findings of skeletal muscles in rimmed vacuole type distal myopathy

    Energy Technology Data Exchange (ETDEWEB)

    Kunimoto, Masanari; Kawai, Mitsuru; Goto, Jun; Nakano, Imaharu

    1987-03-01

    Skeletal muscle CT scans of three patients with biopsy-proven rimmed vacuole type distal myopathy(RVDM) from two unrelated families showed unique involvement pattern of the lower extremities. Parents of the patients in both families are first cousins. T.Y. is a 36-year-old woman who noticed mild difficulty in walking at 34 years of age. Now she shows waddling but still indpendent gait. Manual muscle test (MMT) revealed the following results: fair (3+/5) for hip flexion, 3 for hip extension, 3 for knee flexion, normal (5/5) for knee extension, poor (2/5) for ankle dorsi-flexion, good (4/5) for ankle plantar flexion. T.M., a 34-year-old younger sister of T.Y., started dragging her feet on gait at age 27. She could walk neither on toes nor heels. At present, she can walk only with support. MMT showed the following: 3- and trace (1/5) for hip flexion and extension, 3- and 4 for knee flexion and extension, 1 for ankle plantar- and dorsiflexion. K.W., a 33-year-old woman, began to drag her foot tips in walk and became unable to walk on toes at age 21. The leg weakness progressed into the wheelchair-ridden state at age 30. MMT gave the following results: 1 for hip flexion and extension, 2 and 4 for knee flexion and extension, zero for plantar- and dorsi-flexion. The most impressive CT findings common to these three patients are prominent contrast between the quadriceps muscles and the adductor- and hamstring-group: the former is markedly well preserved even in the most advanced patient (K.W.) while the latter are diffusely and severely affected even in the least affected patient (T.Y.). This finding well coincides with the results of MMT: the knee extensor (quadriceps muscles) fairly well keeps its strength even in the most advanced patient but the knee flexors (adductors and hamstrings) are definitely affected in the early stage of the condition. (J.P.N.).

  13. Bone Regeneration in Odontostomatology

    OpenAIRE

    Tonelli, P; Duvina, M.; Brancato, L.; Delle Rose, G.; Biondi, E.; Civitelli, V.

    2010-01-01

    Maxillary edentulism, together with periodontal disease, is the condition that most frequently induces disruption of alveolar bone tissue. Indeed, the stimulus of the periodontal ligament is lost and the local bone tissue becomes subject to resorption processes that, in the six months following the loss of the tooth, result in alveolar defects or more extensive maxillary atrophy. In both cases, loss of vestibular cortical bone is followed by reduction in the vertical dimension of the alveolar...

  14. Percutaneous Bone Tumor Management

    OpenAIRE

    Gangi, Afshin; Buy, Xavier

    2010-01-01

    Interventional radiology plays a major role in the management of bone tumors. Many different percutaneous techniques are available. Some aim to treat pain and consolidate a pathological bone (cementoplasty); others aim to ablate tumor or reduce its volume (sclerotherapy, thermal ablation). In this article, image-guided techniques of primary and secondary bone tumors with vertebroplasty, ethanol injection, radiofrequency ablation, laser photocoagulation, cryoablation, and radiofrequency ioniza...

  15. Nanocomposites and bone regeneration

    Science.gov (United States)

    James, Roshan; Deng, Meng; Laurencin, Cato T.; Kumbar, Sangamesh G.

    2011-12-01

    This manuscript focuses on bone repair/regeneration using tissue engineering strategies, and highlights nanobiotechnology developments leading to novel nanocomposite systems. About 6.5 million fractures occur annually in USA, and about 550,000 of these individual cases required the application of a bone graft. Autogenous and allogenous bone have been most widely used for bone graft based therapies; however, there are significant problems such as donor shortage and risk of infection. Alternatives using synthetic and natural biomaterials have been developed, and some are commercially available for clinical applications requiring bone grafts. However, it remains a great challenge to design an ideal synthetic graft that very closely mimics the bone tissue structurally, and can modulate the desired function in osteoblast and progenitor cell populations. Nanobiomaterials, specifically nanocomposites composed of hydroxyapatite (HA) and/or collagen are extremely promising graft substitutes. The biocomposites can be fabricated to mimic the material composition of native bone tissue, and additionally, when using nano-HA (reduced grain size), one mimics the structural arrangement of native bone. A good understanding of bone biology and structure is critical to development of bone mimicking graft substitutes. HA and collagen exhibit excellent osteoconductive properties which can further modulate the regenerative/healing process following fracture injury. Combining with other polymeric biomaterials will reinforce the mechanical properties thus making the novel nano-HA based composites comparable to human bone. We report on recent studies using nanocomposites that have been fabricated as particles and nanofibers for regeneration of segmental bone defects. The research in nanocomposites, highlight a pivotal role in the future development of an ideal orthopaedic implant device, however further significant advancements are necessary to achieve clinical use.

  16. Multiple soft tissue aneurysmal cysts: An occurrence after resection of primary aneurysmal bone cyst of fibula

    Directory of Open Access Journals (Sweden)

    Karkuzhali P

    2007-01-01

    Full Text Available We report a case of multiple extraosseous aneurysmal cysts occurring in the muscle and subcutaneous plane of postero-lateral aspects of the upper right leg. They appeared about 15 months after resection of aneurysmal bone cyst of the upper end of the fibula. They varied in size from 2 cm to 5 cm. Radiologically they were well-defined lesions with central septate areas surrounded by a rim of calcification. Histologically they showed central cystic spaces separated by septa consisting of fibroblasts, osteoclast type of giant cells and reactive woven bone. Thus they showed histological similarity with aneurysmal bone cysts, but did not show any connection with the bone. Only very few examples of aneurysmal cysts of soft tissue had been described in the past one decade and they were reported in various locations including rare sites such as arterial wall and larynx. Recent cytogenetic analyses have shown abnormalities involving 17p11-13 and/or 16q22 in both osseous and extraosseous aneurysmal cysts indicating its probable neoplastic nature. Our case had unique features like multiplicity and occurrence after resection of primary aneurysmal bone cyst of the underlying bone.

  17. Imaging of Bone Marrow.

    Science.gov (United States)

    Lin, Sopo; Ouyang, Tao; Kanekar, Sangam

    2016-08-01

    Bone marrow is the essential for function of hematopoiesis, which is vital for the normal functioning of the body. Bone marrow disorders or dysfunctions may be evaluated by blood workup, peripheral smears, marrow biopsy, plain radiographs, computed tomography (CT), MRI and nuclear medicine scan. It is important to distinguish normal spinal marrow from pathology to avoid missing a pathology or misinterpreting normal changes, either of which may result in further testing and increased health care costs. This article focuses on the diffuse bone marrow pathologies, because the majority of the bone marrow pathologies related to hematologic disorders are diffuse. PMID:27444005

  18. Bone marrow fat.

    Science.gov (United States)

    Hardouin, Pierre; Pansini, Vittorio; Cortet, Bernard

    2014-07-01

    Bone marrow fat (BMF) results from an accumulation of fat cells within the bone marrow. Fat is not a simple filling tissue but is now considered as an actor within bone microenvironment. BMF is not comparable to other fat depots, as in subcutaneous or visceral tissues. Recent studies on bone marrow adipocytes have shown that they do not appear only as storage cells, but also as cells secreting adipokines, like leptin and adiponectin. Moreover bone marrow adipocytes share the same precursor with osteoblasts, the mesenchymal stem cell. It is now well established that high BMF is associated with weak bone mass in osteoporosis, especially during aging and anorexia nervosa. But numerous questions remain discussed: what is the precise phenotype of bone marrow adipocytes? What is the real function of BMF, and how does bone marrow adipocyte act on its environment? Is the increase of BMF during osteoporosis responsible for bone loss? Is BMF involved in other diseases? How to measure BMF in humans? A better understanding of BMF could allow to obtain new diagnostic tools for osteoporosis management, and could open major therapeutic perspectives. PMID:24703396

  19. Biophotonics and Bone Biology

    Science.gov (United States)

    Zimmerli, Gregory; Fischer, David; Asipauskas, Marius; Chauhan, Chirag; Compitello, Nicole; Burke, Jamie; Tate, Melissa Knothe

    2004-01-01

    One of the more serious side effects of extended space flight is an accelerated bone loss. Rates of bone loss are highest in the weight-bearing bones of the hip and spine regions, and the average rate of bone loss as measured by bone mineral density measurements is around 1.2% per month for persons in a microgravity environment. It is well known that bone remodeling responds to mechanical forces. We are developing two-photon microscopy techniques to study bone tissue and bone cell cultures to better understand the fundamental response mechanism in bone remodeling. Osteoblast and osteoclast cell cultures are being studied, and the goal is to use molecular biology techniques in conjunction with Fluorescence Lifetime Imaging Microscopy (FLIM) to study the physiology of in-vitro cell cultures in response to various stimuli, such as fluid flow induced shear stress and mechanical stress. We have constructed a two-photon fluorescence microscope for these studies, and are currently incorporating FLIM detection. Current progress will be reviewed. This work is supported by the NASA John Glenn Biomedical Engineering Consortium.

  20. Hypercalciuric Bone Disease

    Science.gov (United States)

    Favus, Murray J.

    2008-09-01

    Hypercalciuria plays an important causal role in many patients with calcium oxalate (CaOx) stones. The source of the hypercalciuria includes increased intestinal Ca absorption and decreased renal tubule Ca reabsorption. In CaOx stone formers with idiopathic hypercalciuria (IH), Ca metabolic balance studies have revealed negative Ca balance and persistent hypercalciuria in the fasting state and during low dietary Ca intake. Bone resorption may also contribute to the high urine Ca excretion and increase the risk of bone loss. Indeed, low bone mass by DEXA scanning has been discovered in many IH patients. Thiazide diuretic agents reduce urine Ca excretion and may increase bone mineral density (BMD), thereby reducing fracture risk. Dietary Ca restriction that has been used unsuccessfully in the treatment of CaOx nephrolithiasis in the past may enhance negative Ca balance and accelerate bone loss. DEXA scans may demonstrate low BMD at the spine, hip, or forearm, with no predictable pattern. The unique pattern of bone histologic changes in IH differs from other causes of low DEXA bone density including postmenopausal osteoporosis, male hypogonadal osteoporosis, and glucocorticoid-induced osteoporosis. Hypercalciuria appears to play an important pathologic role in the development of low bone mass, and therefore correction of urine Ca losses should be a primary target for treatment of the bone disease accompanying IH.

  1. Evaluation of sequential FDG-PET/CT for monitoring bone metastasis of breast cancer during therapy. Correlation between morphological and metabolic changes with tumor markers

    International Nuclear Information System (INIS)

    The purpose of this study was to clarify the significance of positron emission tomography (PET) and computed tomography (CT) findings for evaluating the bone metastasis of breast cancer during therapy. Forty-seven patients with bone metastases from breast cancer who underwent sequential 18F-flourodeoxyglucose (FDG)-PET/CT studies during therapy were enrolled. A total of 771 lesions were identified. The changes in the PET and CT findings were compared with the tumor marker levels in each patient by calculating the weighted kappa value. The correlation between the PET and CT findings was examined for each lesion by an adjusted Chi-square test. The change in the tumor marker levels was substantially correlated with the PET findings and moderately correlated with the CT findings (weighted kappa=0.780 and 0.585 for quadratic weighting, respectively). An increase in FDG uptake was correlated with lytic changes on the CT images (62/65, 95.4%, p<0.05). Sclerotic changes suggested improvement, but sclerosis and progression occurred at the same time in some lesions. Changes of FDG uptake are useful for evaluating individual bone metastases in cases of breast cancer during therapy. Lytic change on CT images suggests progression of bone metastasis. The lysis-progression/sclerosis-improvement pattern was observed in the majority of subjects, but a sclerosis-progression pattern was also observed. The hybrid pattern of increase of FDG uptake on PET/lytic change on CT is most accurate to show progression of bone metastases. Assessments of these processes during therapy are necessary for the precise evaluation of bone metastases. (author)

  2. Buyer's guide to telescopes at the best sites: Dome A, L2, and Shackleton Rim

    Science.gov (United States)

    Angel, J. Roger P.

    2004-10-01

    Future optical/infrared telescopes will need to be much larger than today"s, if they are to address such key challenges as direct observations of Earth-like exoplanets and of the first stars formed after the big bang. In this paper I consider the most promising of the new sites, both on the ground and in space, and telescope concepts to take advantage of their complementary scientific potential. Ground based telescopes with adaptive optics will be capable of diffraction limited imaging, down to a short wavelength limit set by the amplitude and speed of the atmospheric turbulence. The best conditions are on the high Antarctic plateau, where recent measurements at Dome C show turbulence typically half the amplitude of the best temperate sites, with temporal evolution at half the speed1. Thus uniquely in Antarctica, diffraction limited imaging at optical wavelengths should be practical. Conditions there are also best for infrared astronomy, given the combination of minimal aberration and winter temperatures averaging as low as 200K at Dome A (the highest point). In space, well away from the warm Earth, conditions are even better, with 24 hour/day observing free from all atmospheric aberration, and the potential for passive cooling to 50K or less by use of a sunshield. L2 and the Moon's south pole are such optimal space locations. A telescope at L2 requires only a little fuel to stay on orbit, and can be accurately pointed despite solar torques by well established active methods based on star trackers, gyros and reaction wheels. By contrast, the Moon provides a completely stable platform where a telescope with no moving parts can remain pointed indefinitely along the spin axis, or a telescope on a hexapod mount can be oriented and tracked by reaction to the turning lunar surface. Solar shielding on the Moon requires a polar location such as the high rim of the Shackleton crater, adjacent to the south pole, where there is also nearly continuous solar power. Long term

  3. Feasibility and safety of transthoracic echocardiography-guided transcatheter closure of atrial septal defects with deficient superior-anterior rims.

    Science.gov (United States)

    Li, Gui-Shuang; Li, Hai-De; Yang, Jie; Zhang, Wen-Quan; Hou, Zong-Shen; Li, Qing-Chen; Zhang, Yun

    2012-01-01

    Although previous studies showed that transthoracic echocardiography (TTE) can be used to guide transcatheter closure of atrial septal defect (ASD), whether TTE can be used to guide transcatheter closure of secundum ASD with a deficient superior-anterior rim is unknown and this critical issue was addressed in the present study. A total of 280 patients with secundum ASD who underwent transcatheter ASD closure were recruited and divided into groups A and B depending on ASD superior-anterior rim>4 mm (n = 118) or ≤4 mm (n = 162). TTE was used to guide Amplatzer-type septal occluder (ASO) positioning and assess residual shunt. Procedure success was defined as no, trivial and small residual shunt immediately after the procedure as assessed by color Doppler flow imaging. Group A and group B did not differ in complication rate (8.55% vs.7.55%), procedure success rate (98.3% vs. 95.0%) or complete closure rate immediately after the procedure (89.7% vs. 89.3%) or at 6-month follow-up (98.3% vs. 96.8%). The mean procedure and fluoroscopy time in group B were much longer than those in group A. In conclusion, the absence of a sufficient superior-anterior rim in patients undergoing percutaneous closure of secundum-type ASDs using fluoroscopic and TTE guidance is associated with slightly greater device malposition and migration as well as increased procedural and fluoroscopic times, but the overall complication rate did not differ with TTE guidance when compared to historical controls that used TEE guidance. PMID:23284660

  4. Feasibility and safety of transthoracic echocardiography-guided transcatheter closure of atrial septal defects with deficient superior-anterior rims.

    Directory of Open Access Journals (Sweden)

    Gui-Shuang Li

    Full Text Available Although previous studies showed that transthoracic echocardiography (TTE can be used to guide transcatheter closure of atrial septal defect (ASD, whether TTE can be used to guide transcatheter closure of secundum ASD with a deficient superior-anterior rim is unknown and this critical issue was addressed in the present study. A total of 280 patients with secundum ASD who underwent transcatheter ASD closure were recruited and divided into groups A and B depending on ASD superior-anterior rim>4 mm (n = 118 or ≤4 mm (n = 162. TTE was used to guide Amplatzer-type septal occluder (ASO positioning and assess residual shunt. Procedure success was defined as no, trivial and small residual shunt immediately after the procedure as assessed by color Doppler flow imaging. Group A and group B did not differ in complication rate (8.55% vs.7.55%, procedure success rate (98.3% vs. 95.0% or complete closure rate immediately after the procedure (89.7% vs. 89.3% or at 6-month follow-up (98.3% vs. 96.8%. The mean procedure and fluoroscopy time in group B were much longer than those in group A. In conclusion, the absence of a sufficient superior-anterior rim in patients undergoing percutaneous closure of secundum-type ASDs using fluoroscopic and TTE guidance is associated with slightly greater device malposition and migration as well as increased procedural and fluoroscopic times, but the overall complication rate did not differ with TTE guidance when compared to historical controls that used TEE guidance.

  5. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... diagnosis of bone cancer . locate foreign objects in soft tissues around or in bones. top of page How ... Dense bone absorbs much of the radiation while soft tissue, such as muscle, fat and organs, allow more ...

  6. Bone marrow (stem cell) donation

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000839.htm Bone marrow (stem cell) donation To use the sharing ... stem cells from a donor's blood. Types of Bone Marrow Donation There are two types of bone ...

  7. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... or in bones. top of page How should I prepare? Most bone x-rays require no special ... to 10 minutes. top of page What will I experience during and after the procedure? A bone ...

  8. Bone Marrow Aspiration and Biopsy

    Science.gov (United States)

    ... Global Sites Search Help? Bone Marrow Aspiration and Biopsy Share this page: Was this page helpful? Also ... Examination Formal name: Bone Marrow Aspiration; Bone Marrow Biopsy Related tests: Complete Blood Count ; WBC Differential ; Reticulocyte ...

  9. Exercise for Your Bone Health

    Science.gov (United States)

    ... supported by your browser. Home Bone Basics Lifestyle Exercise for Your Bone Health Publication available in: PDF ( ... A Complete Osteoporosis Program For Your Information Why Exercise? Like muscle, bone is living tissue that responds ...

  10. Temporal bone CT findings of tuberculous otitis media : comparison with chronic otitis media

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Jeong A; Rho, Myung Ho; Kim, Young Min; Lee, Ho Seung; Choi, Pil Yeob; Seong, Young Soon; Kwon, Jae Soo; Lee, Sang Wook [Masan Samsung Hospital, Sungkyunkwan Univ. College of Medicine, Seoul (Korea, Republic of); Jung, Keon Sik [Pohang Sunrin Hospital, Pohang (Korea, Republic of)

    1999-06-01

    To compare the differential findings of tuberculous otitis media(TOM) with those of chronic sup purative otitis media with or without cholesteatoma, as seen on high resolution temporal bone CT. We retrospectively reviewed 14 cases of TOM, 30 cases of chronic suppurative otitis media(CSOM), and 30 cases of chronic otitis media with cholesteatoma(Chole). All had been pathologically confirmed. We evaluated the preservation of mastoid cells without sclerotic change, the location and extension of soft tissue to the external auditary canal, and erosion of ossicles, the tegmen tympani, scutum, bony labyrinth, facial nerve canal and sigmoid sinus, and the presence of intracranial complications. Soft tissue in the mastoid antrum was seen in all cases of TOM(100%), 29 cases of CSOM(96.7%), and 26 cases of Chole(86.7%). In contrast, the soft tissue in the entire middle ear cavity was noted in 13 cases of TOM(92.8%), 7 cases of CSOM(23.3%), and 12 cases of Chole(40%). Soft tissue extended to the superior aspect of the external auditory canal in 4 cases of TOM (28.6%) and 5 cases of Chole (16.7%). Mastoid air cells were seen in 9 cases of TOM (64.3%), 4 cases of CSOM (13.3%), and 3 cases of Chole(10%). Ossicular erosion was noted in 6 cases of TOM (42.9%), 12 cases of CSOM (40%), and 26 cases of Chole(86.7%), while in one case of TOM (7.1%), 5 cases of CSOM (16.7%), and 15 cases of Chole(50%) there was erosion of the scutum. In one case of TOM, follow-up CT study after 9 months of antituberculous medication without surgery revealed complete clearing of previously noted soft tissue in the middle ear cavity. Specific CT findings of TOM were not seen, but if there were findings of soft tissue in the entire middle ear cavity, soft tissue extension to the external auditory canal, preservation of mastoid air cells without sclerotic change, and intact scutum, TOM may be differentiated from other chronic otitis media.

  11. Temporal bone CT findings of tuberculous otitis media : comparison with chronic otitis media

    International Nuclear Information System (INIS)

    To compare the differential findings of tuberculous otitis media(TOM) with those of chronic sup purative otitis media with or without cholesteatoma, as seen on high resolution temporal bone CT. We retrospectively reviewed 14 cases of TOM, 30 cases of chronic suppurative otitis media(CSOM), and 30 cases of chronic otitis media with cholesteatoma(Chole). All had been pathologically confirmed. We evaluated the preservation of mastoid cells without sclerotic change, the location and extension of soft tissue to the external auditary canal, and erosion of ossicles, the tegmen tympani, scutum, bony labyrinth, facial nerve canal and sigmoid sinus, and the presence of intracranial complications. Soft tissue in the mastoid antrum was seen in all cases of TOM(100%), 29 cases of CSOM(96.7%), and 26 cases of Chole(86.7%). In contrast, the soft tissue in the entire middle ear cavity was noted in 13 cases of TOM(92.8%), 7 cases of CSOM(23.3%), and 12 cases of Chole(40%). Soft tissue extended to the superior aspect of the external auditory canal in 4 cases of TOM (28.6%) and 5 cases of Chole (16.7%). Mastoid air cells were seen in 9 cases of TOM (64.3%), 4 cases of CSOM (13.3%), and 3 cases of Chole(10%). Ossicular erosion was noted in 6 cases of TOM (42.9%), 12 cases of CSOM (40%), and 26 cases of Chole(86.7%), while in one case of TOM (7.1%), 5 cases of CSOM (16.7%), and 15 cases of Chole(50%) there was erosion of the scutum. In one case of TOM, follow-up CT study after 9 months of antituberculous medication without surgery revealed complete clearing of previously noted soft tissue in the middle ear cavity. Specific CT findings of TOM were not seen, but if there were findings of soft tissue in the entire middle ear cavity, soft tissue extension to the external auditory canal, preservation of mastoid air cells without sclerotic change, and intact scutum, TOM may be differentiated from other chronic otitis media

  12. Experimental Glaucoma Causes Optic Nerve Head Neural Rim Tissue Compression: A Potentially Important Mechanism of Axon Injury

    Science.gov (United States)

    Fortune, Brad; Reynaud, Juan; Hardin, Christy; Wang, Lin; Sigal, Ian A.; Burgoyne, Claude F.

    2016-01-01

    Purpose We tested the hypothesis that experimental glaucoma (EG) results in greater thinning of the optic nerve head (ONH) neural rim tissue than the peripapillary retinal nerve fiber layer (RNFL) tissue. Methods Longitudinal spectral-domain optical coherence tomography (SDOCT) imaging of the ONH and peripapillary RNFL was performed every other week under manometric IOP control (10 mm Hg) in 51 nonhuman primates (NHP) during baseline and after induction of unilateral EG. The ONH parameter minimum rim area (MRA) was derived from 80 radial B-scans centered on the ONH; RNFL cross-sectional area (RNFLA) from a peripapillary circular B-scan with 12° diameter. Results In control eyes, MRA was 1.00 ± 0.19 mm2 at baseline and 1.00 ± 0.19 mm2 at the final session (P = 0.77), while RNFLA was 0.95 ± 0.09 and 0.95 ± 0.10 mm2, respectively (P = 0.96). In EG eyes, MRA decreased from 1.00 ± 0.19 mm2 at baseline to 0.63 ± 0.21 mm2 at the final session (P < 0.0001), while RNFLA decreased from 0.95 ± 0.09 to 0.74 ± 0.19 mm2, respectively (P < 0.0001). Thus, MRA decreased by 36.4 ± 20.6% in EG eyes, significantly more than the decrease in RNFLA (21.7 ± 19.4%, P < 0.0001). Other significant changes in EG eyes included increased Bruch's membrane opening (BMO) nonplanarity (P < 0.05), decreased BMO aspect ratio (P < 0.0001), and decreased MRA angle (P < 0.001). Bruch's membrane opening area did not change from baseline in either control or EG eyes (P = 0.27, P = 0.15, respectively). Conclusions Optic nerve head neural rim tissue thinning exceeded peripapillary RNFL thinning in NHP EG. These results support the hypothesis that axon bundles are compressed transversely within the ONH rim along with glaucomatous deformation of connective tissues. PMID:27564522

  13. ULTRASONIC EVALUATION OF STRESS STATES OF RIMS OF RAILROAD WHEELS. PART 2 — EXPERIENCES AND FUTURE ADAPTATIONS

    OpenAIRE

    Schneider, E.; DYMKIN G.

    2013-01-01

    An ultrasonic technique was developed and different systems are in use to evaluate the stress state of the rim of solid railroad wheels. The measure results received with the UER system versions developed by IZFP as well as the Russian version УКОН-01 was shown and described in the paper. Because the stress state of new wheels is smaller in value than the stress in braked wheels, the influence of a slightly developed texture in new wheels cannot be neglected as it can in case of used wheels. ...

  14. Computer Calculations of Eddy-Current Power Loss in Rotating Titanium Wheels and Rims in Localized Axial Magnetic Fields

    Energy Technology Data Exchange (ETDEWEB)

    Mayhall, D J; Stein, W; Gronberg, J B

    2006-05-15

    We have performed preliminary computer-based, transient, magnetostatic calculations of the eddy-current power loss in rotating titanium-alloy and aluminum wheels and wheel rims in the predominantly axially-directed, steady magnetic fields of two small, solenoidal coils. These calculations have been undertaken to assess the eddy-current power loss in various possible International Linear Collider (ILC) positron target wheels. They have also been done to validate the simulation code module against known results published in the literature. The commercially available software package used in these calculations is the Maxwell 3D, Version 10, Transient Module from the Ansoft Corporation.

  15. Design optimization of a slotless PM brushless motor with helical edge wound laminations for rim driven thrusters

    OpenAIRE

    Sharkh, S.M.; Lai, S. H.

    2010-01-01

    This paper discusses the analysis and design of a very thin slotless PM brushless motor whose stator laminations are manufactured from a single strip of steel that is edge wound into a spiral (like a “Slinky”) and then fitted over the windings that are preformed on the outside surface of a non-conducting former. Analytical and finite element analysis (FEA) are used to determine the constrained optimum dimensions of a motor used to drive a rim driven thruster in which the motor rotor is fitted...

  16. Synthesis and cationic selectivity studies of novel calix[4]arene derivatives containing heteroatom at the lower rim

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A series of calixarene derivatives 2-5 containing heteroatom at the lower rim have been synthesized. 1H NMR studies and crystallographic structures demonstrated that the calix[4]arene derivatives adopted cone conformations. Their cationic binding abilities and selectivities towards heavy and transition metal ions have been evaluated by solvent extraction of aqueous metal picrates. The obtained results indicated that the introduction of nitrogen, sulfur, and/or phosphor atoms to the calix[4]arene framework could effectively enhance their binding ability and selectivity for heavy and transition metal ions, such as Pb2+ or Ag+.

  17. BONES, TEACHER'S GUIDE.

    Science.gov (United States)

    Elementary Science Study, Newton, MA.

    THIS GUIDE WAS DEVELOPED FOR USE WITH THE ELEMENTARY SCIENCE STUDY UNIT ON "BONES.""BONES" HAS BEEN TAUGHT IN THE FOURTH GRADE AND REQUIRES FROM 10 TO 25 LESSONS, DEPENDING ON THE NUMBER OF ACTIVITIES USED. THE GUIDE DOES NOT PROVIDE DETAILED INSTRUCTION FOR CONDUCTING CLASSES, BUT RATHER SOME POSSIBLE ACTIVITIES, AND LEAVES THE DAY-TO-DAY…

  18. Wnt Signaling in Bone

    Science.gov (United States)

    Kubota, Takuo; Michigami, Toshimi; Ozono, Keiichi

    2010-01-01

    Wnt signaling is involved not only in embryonic development but also in maintenance of homeostasis in postnatal tissues. Multiple lines of evidence have increased understanding of the roles of Wnt signaling in bone since mutations in the LRP5 gene were identified in human bone diseases. Canonical Wnt signaling promotes mesenchymal progenitor cells to differentiate into osteoblasts. The canonical Wnt/β-catenin pathway possibly through Lrp6, a co-receptor for Wnts as well as Lrp5, in osteoblasts regulates bone resorption by increasing the OPG/RANKL ratio. However, endogenous inhibitors of Wnt signaling including sclerostin block bone formation. Regulation of sclerostin appears to be one of the mechanisms of PTH anabolic actions on bone. Since sclerostin is almost exclusively expressed in osteocytes, inhibition of sclerostin is the most promising design. Surprisingly, Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum, but not by directly promoting bone formation. Pharmacological intervention may be considered in many components of the canonical Wnt signaling pathway, although adverse effects and tumorigenicity to other tissues are important. More studies will be needed to fully understand how the Wnt signaling pathway actually influences bone metabolism and to assure the safety of new interventions. PMID:23926379

  19. Osteotransductive bone cements.

    Science.gov (United States)

    Driessens, F C; Planell, J A; Boltong, M G; Khairoun, I; Ginebra, M P

    1998-01-01

    Calcium phosphate bone cements (CPBCs) are osteotransductive, i.e. after implantation in bone they are transformed into new bone tissue. Furthermore, due to the fact that they are mouldable, their osteointegration is immediate. Their chemistry has been established previously. Some CPBCs contain amorphous calcium phosphate (ACP) and set by a sol-gel transition. The others are crystalline and can give as the reaction product dicalcium phosphate dihydrate (DCPD), calcium-deficient hydroxyapatite (CDHA), carbonated apatite (CA) or hydroxyapatite (HA). Mixed-type gypsum-DCPD cements are also described. In vivo rates of osteotransduction vary as follows: gypsum-DCPD > DCPD > CDHA approximately CA > HA. The osteotransduction of CDHA-type cements may be increased by adding dicalcium phosphate anhydrous (DCP) and/or CaCO3 to the cement powder. CPBCs can be used for healing of bone defects, bone augmentation and bone reconstruction. Incorporation of drugs like antibiotics and bone morphogenetic protein is envisaged. Load-bearing applications are allowed for CHDA-type, CA-type and HA-type CPBCs as they have a higher compressive strength than human trabecular bone (10 MPa).

  20. Inhibitory Role of Greatwall-Like Protein Kinase Rim15p in Alcoholic Fermentation via Upregulating the UDP-Glucose Synthesis Pathway in Saccharomyces cerevisiae.

    Science.gov (United States)

    Watanabe, Daisuke; Zhou, Yan; Hirata, Aiko; Sugimoto, Yukiko; Takagi, Kenichi; Akao, Takeshi; Ohya, Yoshikazu; Takagi, Hiroshi; Shimoi, Hitoshi

    2016-01-01

    The high fermentation rate of Saccharomyces cerevisiae sake yeast strains is attributable to a loss-of-function mutation in the RIM15 gene, which encodes a Greatwall-family protein kinase that is conserved among eukaryotes. In the present study, we performed intracellular metabolic profiling analysis and revealed that deletion of the RIM15 gene in a laboratory strain impaired glucose-anabolic pathways through the synthesis of UDP-glucose (UDPG). Although Rim15p is required for the synthesis of trehalose and glycogen from UDPG upon entry of cells into the quiescent state, we found that Rim15p is also essential for the accumulation of cell wall β-glucans, which are also anabolic products of UDPG. Furthermore, the impairment of UDPG or 1,3-β-glucan synthesis contributed to an increase in the fermentation rate. Transcriptional induction of PGM2 (phosphoglucomutase) and UGP1 (UDPG pyrophosphorylase) was impaired in Rim15p-deficient cells in the early stage of fermentation. These findings demonstrate that the decreased anabolism of glucose into UDPG and 1,3-β-glucan triggered by a defect in the Rim15p-mediated upregulation of PGM2 and UGP1 redirects the glucose flux into glycolysis. Consistent with this, sake yeast strains with defective Rim15p exhibited impaired expression of PGM2 and UGP1 and decreased levels of β-glucans, trehalose, and glycogen during sake fermentation. We also identified a sake yeast-specific mutation in the glycogen synthesis-associated glycogenin gene GLG2, supporting the conclusion that the glucose-anabolic pathway is impaired in sake yeast. These findings demonstrate that downregulation of the UDPG synthesis pathway is a key mechanism accelerating alcoholic fermentation in industrially utilized S. cerevisiae sake strains.

  1. Usefulness of {sup 18}F fluoride PET/CT in breast cancer patients with osteosclerotic bone metastases

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Seok Ho; Kim, Ku Sang; Kang, Seok Yun; Song, Hee Sung; Jo, Kyung Sook; Lee, Su Jin; Yoon, Joon Kee; An, Young Sil [Ajou Univ., Suwon (Korea, Republic of); Choi, Bong Hoi [Gyeongsang National Univ. Hospital, Jinju (Korea, Republic of)

    2012-03-15

    Bone metastasis is an important factor for the treatment and prognosis of breast cancer patients. Whole body bone scintigraphy (WBBS) can evaluate skeletal metastases, and {sup 18}F FDG PET/CT seems to exhibit high specificity and accuracy in detecting bone metastases. However, there is a limitation of {sup 18}F FDG PET in assessing sclerotic bone metastases because some lesions may be undetectable. Recent studies showed that {sup 18}F fluoride PET/CT is more sensitive than WBBS in detecting bone metastases. This study aims to evaluate the usefulness of {sup 18}F fluoride PET/CT by comparing it with WBBS and {sup 18}F FDG PET/CT in breast cancer patients with osteosclerotic skeletal metastases. Nine breast cancer patients with suspected bone metastases (9 females; mean age {+-} SD, 55.6{+-}10.0 years) underwent {sup 99m}Tc MDP WBBS, {sup 18}F FDG PET/CT and {sup 18}F fluoride PET/CT. Lesion based analysis of five regions of the skeletons(skull, vertebral column, thoracic cage, pelvic bones and long bones of extremities) and patient based analysis were performed. {sup 18}F fluoride PET/CT, {sup 18}F FDG PET/CT and WBBS detected 49, 20 and 25 true metastases, respectively. Sensitivity, specificity, positive predictive value and negative predictive value of {sup 18}F fluoride PET/CT were 94.2%, 46.3%, 57.7% and 91.2%, respectively. Most true metastatic lesions of {sup 18}F fluoride PET/CT had osteosclerotic change (45/49, 91.8%), and only four lesions showed osteolytic change. Most lesions on {sup 18}F FDG PET/CT also demonstrated osteosclerotic change (17/20, 85.0%) with three osteolytic lesions. All true metastatic lesions detected on WBBS and {sup 18}F FDG PET/CT were identified on {sup 18}F fluoride PET/CT. {sup 18}F FDG PET/CT in detecting osteosclerotic metastatic lesions. {sup 18}F fluoride PET/CT might be useful in evaluating osteosclerotic metastases in breast cancer patients.

  2. 2011 Tohoku Earthquake and Japan's Nuclear Disaster - Implications for Indian Ocean Rim countries

    Science.gov (United States)

    Chadha, R. K.

    2011-12-01

    The Nuclear disaster in Japan after the M9.0 Tohoku earthquake on March 11, 2011 has elicited global response to have a relook at the safety aspects of the nuclear power plants from all angles including natural hazards like earthquakes and tsunami. Several countries have gone into safety audits of their nuclear programs in view of the experience in Japan. Tectonically speaking, countries located close to subduction zones or in direct line of impact of the subduction zones are the most vulnerable to earthquake or tsunami hazard, as these regions are the locale of great tsunamigenic earthquakes. The Japan disaster has also cautioned to the possibility of great impact to the critical structures along the coasts due to other ocean processes caused by ocean-atmosphere interactions and also due to global warming and sea level rise phenomena in future. This is particular true for island countries. The 2011 Tohoku earthquake in Japan will be remembered more because of its nuclear tragedy and tsunami rather than the earthquake itself. The disaster happened as a direct impact of a tsunami generated by the earthquake 130 km off the coast of Sendai in the Honshu region of Japan. The depth of the earthquake was about 25 km below the ocean floor and it occurred on a thrust fault causing a displacement of more than 20 meters. At few places, water is reported to have inundated areas up to 8-10 km inland. The height of the tsunami varied between 10 and 3 meters along the coast. Generally, during an earthquake damage to buildings or other structures occur due to strong shaking which is expressed in the form of ground accelerations 'g'. Although, Peak Ground Accelerations (PGA) consistently exceeded 2g at several places from Sendai down south, structures at the Fukushima Daiichi Nuclear Power Plant did not collapse due to the earthquake. In the Indian Ocean Rim countries, Indian, Pakistan and South Africa are the three countries where Nuclear power plants are operational, few of them

  3. PREVALENCE OF SKIN DISEASES IN A DERMATOLOGY OUTPATIENT CLINIC IN RIMS, KADAPA, A CROSS - SECTIONAL, RETROSPECTIVE STUDY

    Directory of Open Access Journals (Sweden)

    Sirisha

    2015-07-01

    Full Text Available BACKGROUND: Dermatological diseases vary widely as a result of geographic location climate socioeconomic status and personal habits and internal factors such as age gender and heredity. OBJECTIVE: The aim of the study was to determine the main causes for outpatient visits in dermatology outpatient clinic in RIMS Kadapa. MATERIALS AND METHOD S: The outpatient clinic records of the department of dermatology RIMS Kadapa, dated between 1 st March 2014 t o 1 st March 2015 were retrospectively assessed. Patients were grouped according to age, gender, and clinical diagnosis. RESULTS: A total of 8,545 new patients with 9,416 skin problems were included in the study. The study group was 52.3% female and 47.7% m ale. The age range was between 1 and 99 years. The most commonly encountered diseases were: contact dermatitis (11.7% of patients, scabies (8.9%, fungal infections (8.9%, urticaria (6.0%, acne (4.4% each. CONCLUSION: It appears that certain skin disea ses contact dermatitis, scabies, fungal infections, urticaria, and acne causes serious health problems. P ublic health policies should be implemented in order to manage these problems rationally.

  4. Low grade coal upgrading: application of liquids from coal (LFC) technology to low grade coals in the Pacific Rim

    Energy Technology Data Exchange (ETDEWEB)

    Castro, J.C.; Horne, D.A.; Nickell, R.; van Hoften, S. [Anatech Applications, San Diego, CA (United States)

    1994-12-31

    The Liquids From Coal (LFC) process was originally tried on low-rank subbituminous coal from the Powder River Basin, USA. This process produced a clean solid fuel, and a petroleum substitute. Transport costs were greatly reduced, and the products complied with the US Clean Air Act amendments. The advantages shown in the subsequent demonstration programme of this light gasification technology led to its consideration for use in the Pacific Rim coal trade. A number of coals from the Pacific Rim countries were evaluated. The most extensive to date has been the testing of Indonesian coals. Indonesia has large coal reserves and will become an important exporter in future. It also has a rapidly growing stock of coal fired power plants. LFC processing was found to be useful for processing coal to meet Japanese, Taiwanese and Hong Kong specifications. An LFC refinery in South Sumatra or Kalimantan could be economic. A solid fuel could be exported, the evolved gas used for process heating, and electric power sold to the Indonesian grid. 4 refs., 5 figs., 6 tabs.

  5. Mesoscale Raised Rim Depressions (MRRDs) on Earth: A Review of the Characteristics, Processes, and Spatial Distributions of Analogs for Mars

    Science.gov (United States)

    Burr, Devon M.; Bruno, Barbara C.; Lanagan, Peter D.; Glaze, Lori; Jaeger, Windy L.; Soare, Richard J.; Tseung, Jean-Michel Wan Bun; Skinner, James A. Jr.; Baloga, Stephen M.

    2008-01-01

    Fields of mesoscale raised rim depressions (MRRDs) of various origins are found on Earth and Mars. Examples include rootless cones, mud volcanoes, collapsed pingos, rimmed kettle holes, and basaltic ring structures. Correct identification of MRRDs on Mars is valuable because different MRRD types have different geologic and/or climatic implications and are often associated with volcanism and/or water, which may provide locales for biotic or prebiotic activity. In order to facilitate correct identification of fields of MRRDs on Mars and their implications, this work provides a review of common terrestrial MRRD types that occur in fields. In this review, MRRDs by formation mechanism, including hydrovolcanic (phreatomagmatic cones, basaltic ring structures), sedimentological (mud volcanoes), and ice-related (pingos, volatile ice-block forms) mechanisms. For each broad mechanism, we present a comparative synopsis of (i) morphology and observations, (ii) physical formation processes, and (iii) published hypothesized locations on Mars. Because the morphology for MRRDs may be ambiguous, an additional tool is provided for distinguishing fields of MRRDs by origin on Mars, namely, spatial distribution analyses for MRRDs within fields on Earth. We find that MRRDs have both distinguishing and similar characteristics, and observation that applies both to their mesoscale morphology and to their spatial distribution statistics. Thus, this review provides tools for distinguishing between various MRRDs, while highlighting the utility of the multiple working hypotheses approach.

  6. Transcriptomic analysis of the role of Rim101/PacC in the adaptation of Ustilago maydis to an alkaline environment.

    Science.gov (United States)

    Franco-Frías, Eduardo; Ruiz-Herrera, Jose; Aréchiga-Carvajal, Elva T

    2014-09-01

    Alkaline pH triggers an adaptation mechanism in fungi that is mediated by Rim101/PacCp, a zinc finger transcription factor. To identify the genes under its control in Ustilago maydis, we performed microarray analyses, comparing gene expression in a wild-type strain versus a rim101/pacC mutation strain of the fungus. In this study we obtained evidence of the large number of genes regulated mostly directly, but also indirectly (probably through regulation of other transcription factors), by Rim101/PacCp, including proteins involved in a large number of physiological activities of the fungus. Our analyses suggest that the response to alkaline conditions under the control of the Pal/Rim pathway involves changes in the cell wall and plasma membrane through alterations in their lipid, protein and polysaccharide composition, changes in cell polarity, actin cytoskeleton organization, and budding patterns. Also as expected, adaptation involves regulation by Rim101/PacC of genes involved in meiotic functions, such as recombination and segregation, and expression of genes involved in ion and nutrient transport, as well as general vacuole functions.

  7. Chondromyxoid fibroma of the acromium with soft tissue extension

    Energy Technology Data Exchange (ETDEWEB)

    Macdonald, D. [Departments of Anatomic and Clinical Pathology, Sunnybrook and Women' s College Health Sciences Centre, Orthopedic and Arthritic Institute, Toronto, Ontario (Canada); University of Toronto, Toronto, Ontario (Canada); Fornasier, V. [Department of Anatomical Pathology and Cytology, St. Michael' s Hospital, Wellesley-Central Site, Toronto, Ontario (Canada); Holtby, R. [Department of Surgery, Sunnybrook and Women' s College Health Sciences Centre, Orthopedic and Arthritic Institute, Toronto, Ontario (Canada)

    2000-03-30

    Chondromyxoid fibroma is an unusual, benign tumor of cartilaginous origin and represents less than 1% of all primary bone tumors. It usually involves the long bones around the knee joint or the flat bones of the pelvis or ribs. Soft tissue extension is also thought to be rare in these lesions. They are usually eccentrically located in the metaphyses of the long bones and centrally in the flat bones. The radiographic appearances are characteristically those of a single, lytic lesion with lobulated margins, septations, cortical expansion and a sclerotic rim. Histologically, they display a lobulated pattern with spindle-shaped cells lying within a myxoid matrix with areas of hyaline cartilage. The differential diagnosis includes giant cell tumor, chondroblastoma or enchondroma as well as chondrosarcoma. The rarity of these lesions may render the diagnosis difficult to make, especially when the lesion involves an unusual site such as the acromium. (orig.)

  8. Enzymatic maceration of bone

    DEFF Research Database (Denmark)

    Uhre, Marie-Louise; Eriksen, Anne Marie; Simonsen, Kim Pilkjær;

    2015-01-01

    This proof of concept study investigates the removal of soft tissue from human ribs with the use of two common methods: boiling with a laundry detergent and using enzymes. Six individuals were autopsied, and one rib from each individual was removed for testing. Each rib was cut into pieces...... the bones. The DNA analysis showed that DNA was preserved on all the pieces of bones which were examined. Finally, the investigation suggests that enzyme maceration could be gentler on the bones, as the edges appeared less frayed. The enzyme maceration was also a quicker method; it took three hours compared...

  9. Periodontal bone lesions

    International Nuclear Information System (INIS)

    In the course of life the periodontum is subject to changes which may be physiological or pathological. Intraoral radiographs give insight into the hard structures of the dentomaxillar region and provides information on lesions in the bone of the periodontum in that they show radiopacities and radiolucencies caused by such lesions. In this thesis the relation is investigated between the true shape and dimensions of periodontal bone lesions and their radiographic images. A method is developed and tested of making standardized and reproducible radiographs suitable for longitudinal studies of periodontal lesions. Also the possibility is demonstrated of an objective and reproducible interpretation of radiographic characteristics of periodontal bone lesions. (Auth.)

  10. Can bone scintigraphy predict the final outcome of pasteurized autografts?

    Energy Technology Data Exchange (ETDEWEB)

    Eid, Ahmed Shawky [Ain Shams University, Department of Orthopedic Surgery, Cairo (Egypt); Jeon, Dae-Geun; Cho, Wan Hyeong [Korea Cancer Center Hospital, Department of Orthopedic Surgery, Seoul (Korea)

    2010-10-15

    As pasteurization is becoming more widely used in limb salvage reconstruction, more study is required to understand about host-graft junction healing, graft revascularization and incorporation, and the incidence and type of complications among pasteurized autografts. This was mainly achieved by follow-up radiography. We aimed to clarify whether Tc99m bone scanning can be considered a reliable method in determining these three parameters. Twenty-seven osteosarcoma patients with pasteurized autograft reconstructions were retrospectively reviewed using available scintigraphic and radiographic follow-up every 6 months postoperatively for 36 months. Follow-up of the unhealed cases was continued for the maximum follow-up period available for each case beyond the original study period, ranging from 1 to 15 months. Tc99m uptake was classified as cold, faint, moderate and high uptake. Junction healing was classified as none, partial and complete healing. Seventy percent of junctions united with a mean of 22 months. Ninety to 100% of junctions showed increased uptake (high or moderate) at one time of the study regardless of final outcome. 85% of the pasteurized grafts showed the characteristic ''tramline appearance''. Four grafts (15%) were complicated: pseudoarthrosis and implant failure (1), fractured plate (1), intramedullary nail (IMN) fracture (1), and prosthesis stem loosening in the host bone (1), with underlying unhealed junctions in all cases. Bone scanning can determine the stages of the graft's rim revascularization and incorporation; however, it cannot detect or predict junction healing or occurrence of complications. Supplementary treatment of unhealed junctions showing either decreased junctional uptake or graft quiescence may be warranted. Otherwise, detection of distant metastasis and early local recurrence remains the main application of Tc99m scanning in the management of bone sarcomas. (orig.)

  11. Acidic microenvironment and bone pain in cancer-colonized bone

    OpenAIRE

    Yoneda, Toshiyuki; Hiasa, Masahiro; Nagata, Yuki; Okui, Tatsuo; White, Fletcher A.

    2015-01-01

    Solid cancers and hematologic cancers frequently colonize bone and induce skeletal-related complications. Bone pain is one of the most common complications associated with cancer colonization in bone and a major cause of increased morbidity and diminished quality of life, leading to poor survival in cancer patients. Although the mechanisms responsible for cancer-associated bone pain (CABP) are poorly understood, it is likely that complex interactions among cancer cells, bone cells and periphe...

  12. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... Professions Site Index A-Z X-ray (Radiography) - Bone Bone x-ray uses a very small dose ... limitations of Bone X-ray (Radiography)? What is Bone X-ray (Radiography)? An x-ray (radiograph) is ...

  13. Interparietal bones in Nigerian skulls.

    OpenAIRE

    Saxena, S. K.; Chowdhary, D S; Jain, S P

    1986-01-01

    The study was conducted on 40 adult Nigerian skulls which were examined for the presence of interparietal and pre-interparietal bones. Only one interparietal bone was found (2.5% of the present series) while a single pre-interparietal bone was found in four skulls (10%) and multiple pre-interparietal bones in one skull (2.5%).

  14. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... News Physician Resources Professions Site Index A-Z X-ray (Radiography) - Bone Bone x-ray uses a very ... of Bone X-ray (Radiography)? What is Bone X-ray (Radiography)? An x-ray (radiograph) is a noninvasive ...

  15. Effects of Carburized Parts on Residual Stresses of Thin-Rimmed Spur Gears with Symmetric Web Arrangements Due to Case-Carburizing

    Institute of Scientific and Technical Information of China (English)

    Kouitsu Miyachika; Wei-Dong Xue; Satoshi Oda; Hidefumi Mada; Hiroshige Fujio

    2004-01-01

    This paper presents a study on effects of carburized parts on residual stresses of thin-rimmed spur gears with symmetric web arrangements due to the case-carburizing. The carbon content of each element of the FEM gear model due to carburizing was obtained according to Vickers hardness Hv - carbon content C% and C% - d (distance from surface)charts. A heat conduction analysis and an elastic-plastic stress analysis during the case-carburizing process of thin-rimmed spur gears with symmetric web arrangements were carried out for various case-carburizing conditions by using the three-dimensional finite element method (3D-FEM) program developed by authors, and then residual stresses were obtained.The effects of the carburized part, the web structure, and the rim thickness on the residual stress were determined.

  16. Osteomyelitis of frontal bone

    OpenAIRE

    Chaturvedil, V. N.; Raizada, R. M.; Singh, A. K. Kennedy; Puttewar, M. P.; Bali, S.

    2004-01-01

    A case of Osteomyelitis of the frontal bone with a subperiosteal absces s, an extrudural abscess and a frontal sinus fistula is presented here for its rarity. A brief review of literature and management of the condition is also discussed.

  17. Proximal Tibial Bone Graft

    Science.gov (United States)

    ... Complications Potential problems after a PTBG include infection, fracture of the proximal tibia and pain related to the procedure. Frequently Asked Questions If proximal tibial bone graft is taken from my knee, will this prevent me from being able to ...

  18. Bone healing: little secrets

    OpenAIRE

    Einhorn, T. A.

    2011-01-01

    The development of new strategies to enhance the healing of fractures continues to evolve with the introduction of both locally and systemically delivered compounds. The recent refinement in the use of autologous bone marrow as a bone graft material has brought the field of stem cell biology into orthopaedic practice. New recombinant peptides such as platelet- derived growth factor and teriparatide show promise as local and systemic enhancers respectively. Finally, recent evidence that mutati...

  19. Small Animal Bone Biomechanics

    OpenAIRE

    Vashishth, Deepak

    2008-01-01

    Animal models, in particular mice, offer the possibility of naturally achieving or genetically engineering a skeletal phenotype associated with disease and conducting destructive fracture tests on bone to determine the resulting change in bone’s mechanical properties. Several recent developments, including nano- and micro- indentation testing, microtensile and microcompressive testing, and bending tests on notched whole bone specimens, offer the possibility to mechanically probe small animal ...

  20. SHEEP TEMPORAL BONE

    Directory of Open Access Journals (Sweden)

    Kesavan

    2016-03-01

    Full Text Available INTRODUCTION Human temporal bones are difficult to procure now a days due to various ethical issues. Sheep temporal bone is a good alternative due to morphological similarities, easy to procure and less cost. Many middle ear exercises can be done easily and handling of instruments is done in the procedures like myringoplasty, tympanoplasty, stapedotomy, facial nerve dissection and some middle ear implants. This is useful for resident training programme.

  1. FRACTURE NASAL BONES

    OpenAIRE

    Balasubramanian Thaigarajan; Venkatesan Ulaganathan

    2013-01-01

    Nose is the most prominent part of the face, hence it is likely to be the most common structure to be injured in the face. Although fractures involving the nasal bones are very common, it is often ignored by the patient. Patients with fractures of nasal bone will have deformity, tenderness, haemorrhage, edema, ecchymosis, instability, and crepitation. These features may be present in varying combinations. This article discusses the pathophysiology of these fractures, role of radiography a...

  2. Fracture Nasal Bone

    OpenAIRE

    Balasubramanian, Thiagarajan; Venkatesan, Ulaganathan

    2013-01-01

    Nose is the most prominent part of the face, hence it is likely to be the most common structure to be injured in the face. Although fractures involving the nasal bones are very common, it is often ignored by the patient. Patients with fractures of nasal bone will have deformity, tenderness, haemorrhage, edema, ecchymosis, instability, and crepitation. These features may be present in varying combinations. This article discusses the pathophysiology of these fractures, role of radiography and u...

  3. Bone Metabolism in Anorexia Nervosa

    OpenAIRE

    Fazeli, Pouneh K.; Klibanski, Anne

    2014-01-01

    Anorexia nervosa (AN), a psychiatric disorder predominantly affecting young women, is characterized by self-imposed chronic nutritional deprivation and distorted body image. AN is associated with a number of medical co-morbidities including low bone mass. The low bone mass in AN is due to an uncoupling of bone formation and bone resorption, which is the result of hormonal adaptations aimed at decreasing energy expenditure during periods of low energy intake. Importantly, the low bone mass in ...

  4. VNIR Multispectral Observations of Rocks at Spirit of St. Louis Crater and Marathon Valley on Th Rim of Endeavour Crater Made by the Opportunity Rover Pancam

    Science.gov (United States)

    Farrand, W. H.; Johnson, J. R.; Bell, J. F., III; Mittlefehldt, D.W.

    2016-01-01

    The Mars Exploration Rover Opportunity has been exploring the western rim of the 22 km diameter Endeavour crater since August, 2011. Recently, Opportunity has reached a break in the Endeavour rim that the rover team has named Mara-thon Valley. This is the site where orbital observations from the MRO CRISM imaging spectrometer indicated the presence of iron smectites. On the outer western portion of Marathon Valley, Opportunity explored the crater-form feature dubbed Spirit of St. Louis (SoSL) crater. This presentation describes the 430 to 1009 nm (VNIR) reflectance, measured by the rover's Pancam, of rock units present both at Spirit of St. Louis and within Marathon Valley.

  5. Recombinant human bone morphogenetic protein induces bone formation

    International Nuclear Information System (INIS)

    The authors have purified and characterized active recombinant human bone morphogenetic protein (BMP) 2A. Implantation of the recombinant protein in rats showed that a single BMP can induce bone formation in vivo. A dose-response and time-course study using the rat ectopic bone formation assay revealed that implantation of 0.5-115 μg of partially purified recombinant human BMP-2A resulted in cartilage by day 7 and bone formation by day 14. The time at which bone formation occurred was dependent on the amount of BMP-2A implanted; at high doses bone formation could be observed at 5 days. The cartilage- and bone-inductive activity of the recombinant BMP-2A is histologically indistinguishable from that of bone extracts. Thus, recombinant BMP-2A has therapeutic potential to promote de novo bone formation in humans

  6. Greenhouse gas emissions trading among Pacific Rim countries: An analysis of policies to bring developing countries to the bargaining table

    International Nuclear Information System (INIS)

    This paper examines the aggregate net costs and individual country cost savings of greenhouse gas emissions trading among Pacific Rim countries. We propose emission permit allocation rules designed to entice developing countries to participate. Absence of developing country involvement has served as an excuse for the lack by participation by the United States in the first compliance period of the Kyoto Protocol and may serve as a disincentive to even more countries in subsequent periods. Our analysis specifies permit allocation rules that could result in no net costs, and even cost-savings, to developing countries for their involvement in the emissions trading market, while at the same time providing extensive benefits to industrialized countries through access to lower-cost mitigation alternatives

  7. A STUDY ON PREVALENCE OF DEPRESSION IN ATTEMPTED SUICIDE PATIENTS ATTENDING R.I.M.S . HOSPITAL, IMPHAL

    Directory of Open Access Journals (Sweden)

    Hemchand Singh

    2014-02-01

    Full Text Available OBJECTIVE: To evaluate prevalence of depression in individuals who attempted suicide and attended Regional Institute of Medical Sciences Hospital , Imphal. Method: The study was cross - sectional in which 50 patients who attempted suicide and attend ed RIMS Hospital and fulfilled the inclusion criteria were included in the study which was conducted from November 2005 to October 2006. A semi - structured interview schedule was used to find out the socio - demographic profile. Present State Examination was used for symptom elicitation and ICCD - 10 was used for confirming the diagnosis. RESULTS : Males (64% outnumbered females. Sixty - four present had psychiatric illness , depressive episode (28% being the most common diagnosis. CONCLUSION : Depressives episode was found to be commonest psychiatric illness in patients who attempted suicide.

  8. Porous surface modified bioactive bone cement for enhanced bone bonding.

    Directory of Open Access Journals (Sweden)

    Qiang He

    Full Text Available BACKGROUND: Polymethylmethacrylate bone cement cannot provide an adhesive chemical bonding to form a stable cement-bone interface. Bioactive bone cements show bone bonding ability, but their clinical application is limited because bone resorption is observed after implantation. Porous polymethylmethacrylate can be achieved with the addition of carboxymethylcellulose, alginate and gelatin microparticles to promote bone ingrowth, but the mechanical properties are too low to be used in orthopedic applications. Bone ingrowth into cement could decrease the possibility of bone resorption and promote the formation of a stable interface. However, scarce literature is reported on bioactive bone cements that allow bone ingrowth. In this paper, we reported a porous surface modified bioactive bone cement with desired mechanical properties, which could allow for bone ingrowth. MATERIALS AND METHODS: The porous surface modified bioactive bone cement was evaluated to determine its handling characteristics, mechanical properties and behavior in a simulated body fluid. The in vitro cellular responses of the samples were also investigated in terms of cell attachment, proliferation, and osteoblastic differentiation. Furthermore, bone ingrowth was examined in a rabbit femoral condyle defect model by using micro-CT imaging and histological analysis. The strength of the implant-bone interface was also investigated by push-out tests. RESULTS: The modified bone cement with a low content of bioactive fillers resulted in proper handling characteristics and adequate mechanical properties, but slightly affected its bioactivity. Moreover, the degree of attachment, proliferation and osteogenic differentiation of preosteoblast cells was also increased. The results of the push-out test revealed that higher interfacial bonding strength was achieved with the modified bone cement because of the formation of the apatite layer and the osseointegration after implantation in the bony

  9. Progressive dry-core-wet-rim hydration trend in a nested-ring topology of protein binding interfaces

    Directory of Open Access Journals (Sweden)

    Li Zhenhua

    2012-03-01

    Full Text Available Abstract Background Water is an integral part of protein complexes. It shapes protein binding sites by filling cavities and it bridges local contacts by hydrogen bonds. However, water molecules are usually not included in protein interface models in the past, and few distribution profiles of water molecules in protein binding interfaces are known. Results In this work, we use a tripartite protein-water-protein interface model and a nested-ring atom re-organization method to detect hydration trends and patterns from an interface data set which involves immobilized interfacial water molecules. This data set consists of 206 obligate interfaces, 160 non-obligate interfaces, and 522 crystal packing contacts. The two types of biological interfaces are found to be drier than the crystal packing interfaces in our data, agreeable to a hydration pattern reported earlier although the previous definition of immobilized water is pure distance-based. The biological interfaces in our data set are also found to be subject to stronger water exclusion in their formation. To study the overall hydration trend in protein binding interfaces, atoms at the same burial level in each tripartite protein-water-protein interface are organized into a ring. The rings of an interface are then ordered with the core atoms placed at the middle of the structure to form a nested-ring topology. We find that water molecules on the rings of an interface are generally configured in a dry-core-wet-rim pattern with a progressive level-wise solvation towards to the rim of the interface. This solvation trend becomes even sharper when counterexamples are separated. Conclusions Immobilized water molecules are regularly organized in protein binding interfaces and they should be carefully considered in the studies of protein hydration mechanisms.

  10. Nd and Sr isotope compositions in modern and fossil bones - Proxies for vertebrate provenance and taphonomy

    Science.gov (United States)

    Tütken, Thomas; Vennemann, Torsten W.; Pfretzschner, Hans-U.

    2011-10-01

    Rare earth elements (REE), while not essential for the physiologic functions of animals, are ingested and incorporated in ppb concentrations in bones and teeth. Nd isotope compositions of modern bones of animals from isotopically distinct habitats demonstrate that the 143Nd/ 144Nd of the apatite can be used as a fingerprint for bedrock geology or ambient water mass. This potentially allows the provenance and migration of extant vertebrates to be traced, similar to the use of Sr isotopes. Although REE may be enriched by up to 5 orders of magnitude during diagenesis and recrystallization of bone apatite, in vivo143Nd/ 144Nd may be preserved in the inner cortex of fossil bones or enamel. However, tracking the provenance of ancient or extinct vertebrates is possible only for well-preserved archeological and paleontological skeletal remains with in vivo-like Nd contents at the ppb-level. Intra-bone and -tooth REE analysis can be used to screen for appropriate areas. Large intra-bone Nd concentration gradients of 10 1-10 3 are often measured. Nd concentrations in the inner bone cortex increase over timescales of millions of years, while bone rims may be enriched over millenial timescales. Nevertheless, ɛ Nd values are often similar within one ɛ Nd unit within a single bone. Larger intra-bone differences in specimens may either reflect a partial preservation of in vivo values or changing ɛ Nd values of the diagenetic fluid during fossilization. However, most fossil specimens and the outer rims of bones will record taphonomic 143Nd/ 144Nd incorporated post mortem during diagenesis. Unlike REE patterns, 143Nd/ 144Nd are not biased by fractionation processes during REE-uptake into the apatite crystal lattice, hence the ɛ Nd value is an important tracer for taphonomy and reworking. Bones and teeth from autochthonous fossil assemblages have small variations of ±1 ɛ Nd unit only. In contrast, fossil bones and teeth from over 20 different marine and terrestrial fossil

  11. Virtual Temporal Bone Anatomy

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Background The Visible Human Project(VHP) initiated by the U.S. National Library of Medicine has drawn much attention and interests from around the world. The Visible Chinese Human (VCH) project has started in China. The current study aims at acquiring a feasible virtual methodology for reconstructing the temporal bone of the Chinese population, which may provide an accurate 3-D model of important temporal bone structures that can be used in teaching and patient care for medical scientists and clinicians. Methods A series of sectional images of the temporal bone were generated from section slices of a female cadaver head. On each sectional image, SOIs (structures of interest) were segmented by carefully defining their contours and filling their areas with certain gray scale values. The processed volume data were then inducted into the 3D Slicer software(developed by the Surgical Planning Lab at Brigham and Women's Hospital and the MIT AI Lab) for resegmentation and generation of a set of tagged images of the SOIs. 3D surface models of SOIs were then reconstructed from these images. Results The temporal bone and structures in the temporal bone, including the tympanic cavity, mastoid cells, sigmoid sinus and internal carotid artery, were successfully reconstructed. The orientation of and spatial relationship among these structures were easily visualized in the reconstructed surface models. Conclusion The 3D Slicer software can be used for 3-dimensional visualization of anatomic structures in the temporal bone, which will greatly facilitate the advance of knowledge and techniques critical for studying and treating disorders involving the temporal bone.

  12. A scintigraphic study of composited bone substitute in the repair of bone defect of femoral head%复合人工骨修复股骨头骨缺损的影像学研究

    Institute of Scientific and Technical Information of China (English)

    同志勤; 徐小良; 王坤正; 宋厂义

    2001-01-01

    Objective To evaluate the effect of bBMP-collagen-coral composited bone substitute in treatment of osteonecrosis of the femoral head(ONFH).Methods Canine bone defect of bilateral femoral head was established,They were devided into 4 groups:Ⅰ.composited bone substitute group(n=5),Ⅱ.muscle pedicle bone group (n=5),Ⅲ.simple coral group(n=4),Ⅳ.control group:contralateral hip(n=14).Roentgenography,Scintigraphy,MRI,CT were examined and studied at various time.Results ①Scintigraphic changes:In group Ⅰ,static bone image showed increased radionuclide uptake,but blood flow and blood-pool image didn't show in 6 and 12 week;②MRI:There was much more new bone formation in the bone defect of group Ⅰ;In group Ⅳ,there was fatty bone marrow which was surrounded with sclerotic bone;③Resules of roentgenographic and CT:In 14-16 weeks,in group Ⅰ,the coral was absorbed and most of the bone defects were closed completely;In the rest groups,part of each bone defect was remained except that in group Ⅳ,cystic sclerosis was formed.Conclusion The composited bone substitute possesses a superior osteoinductivity and osteoconductivity in the repair of bone defect of femoral head,but it can't improve the revascularization of ONFH.%目的研究用复合人工骨治疗股骨头坏死的效果。方法建立双侧股骨头内骨缺损模型,并分为4组:bBMP-胶原-珊瑚复合人工骨组(5侧)、肌骨瓣组(5侧)、单纯珊瑚组(4侧)、对照组(14侧,为以上各组的对侧)。造模及植入后定时行X线、核素骨显像、MRI及CT检查。结果①核素骨显像示:6周及12周,Ⅰ组股骨头核素摄取量静态相头/干比升高,但血流相及血池相不升高。②MRI:10周示Ⅰ组骨缺损内多量新生骨形成,Ⅳ组骨缺损内囊腔中为脂肪性信号,周围为低信号的硬化带。③拍片及CT示:14~16周,Ⅰ组骨缺损大多完全闭合,珊瑚已吸收,其余各组骨缺损部分残

  13. Periostin action in bone.

    Science.gov (United States)

    Bonnet, Nicolas; Garnero, Patrick; Ferrari, Serge

    2016-09-01

    Periostin is a highly conserved matricellular protein that shares close homology with the insect cell adhesion molecule fasciclin 1. Periostin is expressed in a broad range of tissues including the skeleton, where it serves both as a structural molecule of the bone matrix and a signaling molecule through integrin receptors and Wnt-beta-catenin pathways whereby it stimulates osteoblast functions and bone formation. The development of periostin null mice has allowed to elucidate the crucial role of periostin on dentinogenesis and osteogenesis, as well as on the skeletal response to mechanical loading and parathyroid hormone. The use of circulating periostin as a potential clinical biomarker has been explored in different non skeletal conditions. These include cancers and more specifically in the metastasis process, respiratory diseases such as asthma, kidney failure, renal injury and cardiac infarction. In postmenopausal osteoporosis, serum levels have been shown to predict the risk of fracture-more specifically non-vertebral- independently of bone mineral density. Because of its preferential localization in cortical bone and periosteal tissue, it can be speculated that serum periostin may be a marker of cortical bone metabolism, although additional studies are clearly needed. PMID:26721738

  14. Bone metabolism during pregnancy.

    Science.gov (United States)

    Salles, Jean Pierre

    2016-06-01

    During pregnancy, mineral concentrations, of calcium and phosphorus in particular, are maintained at a high level in fetal blood so that the developing skeleton may accrete adequate mineral content. The placenta actively transports minerals for this purpose. Maternal intestinal absorption increases in order to meet the fetal demand for calcium, which is only partly dependent on calcitriol. Mineral regulation is essentially dependent on parathyroid hormone (PTH) and PTH-related protein (PTHrP). The calcium-sensing receptor (CaSR) regulates PTH and PTHrP production. If calcium intake is insufficient, the maternal skeleton will undergo resorption due to PTHrP. After birth, a switch from fetal to neonatal homeostasis occurs through increase in PTH and calcitriol, and developmental adaptation of the kidneys and intestines with bone turnover contributing additional mineral to the circulation. Calcium absorption becomes progressively active and dependent on calcitriol. The postnatal skeleton can transiently present with osteoposis but adequate mineral diet usually allows full restoration. Cases of primary osteoporosis must be identified. Loss of trabecular mineral content occurs during lactation in order to provide calcium to the newborn. This programmed bone loss is dependent on a "brain-breast-bone" circuit. The physiological bone resorption during reproduction does not normally cause fractures or persistent osteoporosis. Women who experience fracture are likely to have other causes of bone loss. PMID:27157104

  15. Inca bones at asterion

    Directory of Open Access Journals (Sweden)

    Prashant E Natekar

    2014-01-01

    Full Text Available Background: Surgical approach towards asterion has to be done with caution as many surgeons are unfamiliar with the anatomical variations. The asterion corresponds to the site of the posterolateral (mastoid fontanelle of the neonatal skull which closes at the end of the first year. Inca bones provide information as markers for various diseases, and can mislead in the diagnosis of fractures. Observation and Results: 150 dry skull bones from the Department of Anatomy at Goa Medical College, India and other neighboring medical colleges by examining the asterion, and its sutural articulations with parietal, temporal and occipital bones and also anatomical variations if any in adults. Discussion: The anatomical landmarks selected must be reliable and above all easy to identify. Bony structures are more suitable than soft tissue or cartilaginous landmarks because of their rigid and reliable location. Presence of these bones provides false impressions of fractures or the fractures may be interpreted for inca bones especially in the region of asterion either radiologically or clinically which may lead to complications during burr hole surgeries.

  16. Fibrosarcoma of bone

    International Nuclear Information System (INIS)

    A general clinical-radiological description of fibrosarcoma of bone, including tumours with features of malignant fibrous histiocytoma is presented. 104 patients with fibrosarcoma of the long bones are analysed in terms of age and sex distribution, symptoms, duration of symptoms and tumour localization. The radiological findings obtained in patients with fibrosarcoma of the long bones are discussed. The treatment and course of fibrosarcoma of the long bones are discussed. Data on the type of therapy given were available on 103 patients: 67 were treated by ablative surgery either immediately or within three months of preceding local surgery and/or radiotherapy. In the remaining 36 cases treatment consisted of local surgery, radiotherapy or a combination of these, or non-curative (palliative) treatment. In a few cases ablative surgery was performed at a later stage. 13 patients with fibrosarcoma of the axial skeleton and 14 with fibrosarcoma of the jaws are considered. A causistic discussion of patients with a secondary fibrosarcoma is presented. Secondary fibrosarcoma was found in a total of 19 patients (14%); 4 after irradiation. The features of significance for the course of the disease are discussed: general features such as age and sex, tumour localization in the long bones, presence or absence of a pathological fracture, and the radiological and histological characteristics of the tumour. The type of therapy and the occurrence of lung metastases in relation to the course of the disease is also discussed. (Auth.)

  17. Temperature Prediction Model for Bone Drilling Based on Density Distribution and In Vivo Experiments for Minimally Invasive Robotic Cochlear Implantation.

    Science.gov (United States)

    Feldmann, Arne; Anso, Juan; Bell, Brett; Williamson, Tom; Gavaghan, Kate; Gerber, Nicolas; Rohrbach, Helene; Weber, Stefan; Zysset, Philippe

    2016-05-01

    cumulative equivalent minutes suggest that thermal elevation of this minimally invasive cochlear implantation surgery may pose a risk to the facial nerve, especially in sclerotic or high density mastoid bones. Optimized drilling parameters need to be evaluated and the model could be used for future risk evaluation. PMID:26358479

  18. 轻量化无内胎轮辋失效分析与改进%Lightweight tubeless rims Failure Analysis and Improvement

    Institute of Scientific and Technical Information of China (English)

    袁丽; 刘晓敏

    2014-01-01

    为解决轻量化无内胎轮辋总成失效率高的问题,采用质量工具及理化分析方法,找出了影响轮辋总成失效的关键影响因子,提出从设计方面对轮辋总成进行改进,并通过CAE分析方法对改善前后的轮辋总成结构进行了应力应变分析及验证,改进效果佳。%To solve the lightweight tubeless rim assembly failure rate issues, the use of quality tools and chemical analysis methods to identify the key influence rim assembly failure factor, made from the design aspects of the rim assembly to improve, with CAE analysis methods for structural improvements to the front and rear rim assembly were stress-strain analysis and verification, improved results were obvious.

  19. Non-Thermal X-ray Emission from the Northwestern Rim of the Galactic Supernova Remnant G266.2-1.2 (RX J0852.0-4622)

    CERN Document Server

    Pannuti, Thomas G; Filipovic, Miroslav D; De Horta, Ain; Stupar, Milorad; Agrawal, Rashika

    2010-01-01

    We present a detailed spatially-resolved spectroscopic analysis of two X-ray observations (with a total integration time of 73280 seconds) made of the luminous northwestern rim complex of the Galactic supernova remnant (SNR) G266.2-1.2 (RX J0852.0-4622) with the Chandra X-ray Observatory. G266.2-1.2 is a member of a class of Galactic SNRs which feature X-ray spectra dominated by non-thermal emission: in the cases of these SNRs, the emission is believed to have a synchrotron origin and studies of the X-ray spectra of these SNRs can lend insights into how SNRs accelerate cosmic-ray particles. The Chandra observations have clearly revealed fine structure in this rim complex and the spectra of these features are dominated by non-thermal emission. We have measured the length scales of the upstream structures at eight positions along the rim and derive lengths of 0.02-0.08 pc (assuming a distance of 750 pc to G266.2-1.2). We have also extracted spectra from seven regions in the rim complex and fit these spectra wit...

  20. Rim pélvico de doador vivo-relacionado para transplante: relato de caso e revisão da literatura

    Directory of Open Access Journals (Sweden)

    Tobias August Siemens

    2015-09-01

    Full Text Available ResumoIntrodução:É cada vez maior a discrepância entre a fila de espera e a oferta para um transplante renal. Fica evidente a necessidade de se usar enxertos com critérios expandidos, como, por exemplo, rim pélvico, conforme relatamos a seguir.Relato de caso:Paciente masculino de 25 anos, com doença renal crônica estádio 5, recebe como enxerto rim pélvico do pai, 49 anos, com história prévia de hipertensão arterial sistêmica bem controlada e urolitíase há mais de 10 anos sem novos episódios. Função e anatomia do rim pélvico foram avaliadas com exames de imagem como ressonância magnética, tomografia computadorizada e cintilografia. Após rejeição inicial tratada adequadamente, paciente apresenta boa evolução.Conclusão:Para aumentar oferta de rins para doação, é possível a utilização de rim pélvico, desde que adequadamente estudado no pré-operatório.

  1. Bone Regeneration Using Bone Morphogenetic Proteins and Various Biomaterial Carriers

    Directory of Open Access Journals (Sweden)

    Zeeshan Sheikh

    2015-04-01

    Full Text Available Trauma and disease frequently result in fractures or critical sized bone defects and their management at times necessitates bone grafting. The process of bone healing or regeneration involves intricate network of molecules including bone morphogenetic proteins (BMPs. BMPs belong to a larger superfamily of proteins and are very promising and intensively studied for in the enhancement of bone healing. More than 20 types of BMPs have been identified but only a subset of BMPs can induce de novo bone formation. Many research groups have shown that BMPs can induce differentiation of mesenchymal stem cells and stem cells into osteogenic cells which are capable of producing bone. This review introduces BMPs and discusses current advances in preclinical and clinical application of utilizing various biomaterial carriers for local delivery of BMPs to enhance bone regeneration.

  2. Bone printing: new frontiers in the treatment of bone defects.

    Science.gov (United States)

    Arealis, Georgios; Nikolaou, Vasileios S

    2015-12-01

    Bone defects can be congenital or acquired resulting from trauma, infection, neoplasm and failed arthroplasty. The osseous reconstruction of these defects is challenging. Unfortunately, none of the current techniques for the repair of bone defects has proven to be fully satisfactory. Bone tissue engineering (BTE) is the field of regenerative medicine (RM) that focuses on alternative treatment options for bone defects that will ideally address all the issues of the traditional techniques in treating large bone defects. However, current techniques of BTE is laborious and have their own shortcomings. More recently, 2D and 3D bone printing has been introduced to overcome most of the limitations of bone grafts and BTE. So far, results are extremely promising, setting new frontiers in the management of bone defects.

  3. 浙江省淳安县发生桑叶菌核病的病原与发病规律调查%An Investigation to Pathogen and Occurrence Regularity of Mulberry Leaf Sclerote Disease Occurring in Chun'an County of Zhejiang Province

    Institute of Scientific and Technical Information of China (English)

    肖建京; 蒯元璋; 张帆; 丰卫忠

    2012-01-01

    An peculiar and severe mulberry leaf spot disease happened in mulberry field of Chun'an Country, Zhejiang Province in autumn of 2011. The diseased leaves presented typical symptoms of sclerote disease; grayish brown, ring pattern and water-soaked disease spots formed on surface of leaves; disease spots extended outward concentrically with onset of disease; color of the disease spots deepened from inside to outside; and many concentric circle-shaped and villous mycelia and conidiospores appeared at grey and round-shaped disease spots on leaf back. Optical microscopic observation confirmed morphology of mycelia and conidiospores in tissues from disease spots, tissues surrounding the disease spots, and villous tissues from concentric circles of the disease spots. Sclerotia formed by mycelium could be observed from pathogens isolated and cultured on PDA medium by using peripheric tissues of the disease spots. Based on the above symptoms and morphological features of isolated and cultured pathogenic fungus, this disease was identi fied as mulberry leaf sclerote disease. Its pathogenic fungus was Sclerotinia fuckeliana (de Bary) Fuck.. A survey conducted to 480 mulberry trees at 16 test sites showed that disease incidence on plants was 81. 25%, disease incidence on leaves was 37. 63%, and disease index was 18. 5. In September and October of 2011, the local temperature was 24. 4 ~18. 7 ℃ and rainy weather continued for a long time. In addition, the local collective mulberry fields had poor ventilation and illumination condition, creating an environment of high relative humidity. Therefore, the pathogenic fungi reproduced rapidly and the disease became epidemic. No mulberry variety has been found to have obvious resistance against it.%2011年秋季,浙江省淳安县的桑园大面积发生一种罕见的桑叶特大病斑病害.病叶呈现菌核病的典型症状:叶面形成灰褐色轮纹水渍状病斑,病斑随着病情发展以同心圆状向外

  4. Biochemical markers of bone turnover

    International Nuclear Information System (INIS)

    Biochemical markers of bone turnover has received increasing attention over the past few years, because of the need for sensitivity and specific tool in the clinical investigation of osteoporosis. Bone markers should be unique to bone, reflect changes of bone less, and should be correlated with radiocalcium kinetics, histomorphometry, or changes in bone mass. The markers also should be useful in monitoring treatment efficacy. Although no bone marker has been established to meet all these criteria, currently osteocalcin and pyridinium crosslinks are the most efficient markers to assess the level of bone turnover in the menopausal and senile osteoporosis. Recently, N-terminal telopeptide (NTX), C-terminal telopeptide (CTX) and bone specific alkaline phosphatase are considered as new valid markers of bone turnover. Recent data suggest that CTX and free deoxypyridinoline could predict the subsequent risk of hip fracture of elderly women. Treatment of postmenopausal women with estrogen, calcitonin and bisphosphonates demonstrated rapid decrease of the levels of bone markers that correlated with the long-term increase of bone mass. Factors such as circadian rhythms, diet, age, sex, bone mass and renal function affect the results of biochemical markers and should be appropriately adjusted whenever possible. Each biochemical markers of bone turnover may have its own specific advantages and limitations. Recent advances in research will provide more sensitive and specific assays

  5. Bone Targeted Therapies for Bone Metastasis in Breast Cancer

    OpenAIRE

    Wajeeha Razaq

    2013-01-01

    Cancer metastasis to the bone develops commonly in patients with various malignancies, and is a major cause of morbidity and diminished quality of life in many affected patients. Emerging treatments for metastatic bone disease have arisen from advances in our understanding of the unique cellular and molecular mechanisms that contribute to the bone metastasis. The tendency of cancer cells to metastasize to bone is probably the end result of many factors including vascular pathways, the highly ...

  6. Archival bone marrow samples

    DEFF Research Database (Denmark)

    Lund, Bendik; Najmi, Laeya A; Wesolowska-Andersen, Agata;

    2015-01-01

    AB Archival samples represent a significant potential for genetic studies, particularly in severe diseases with risk of lethal outcome, such as in cancer. In this pilot study, we aimed to evaluate the usability of archival bone marrow smears and biopsies for DNA extraction and purification, whole...... with samples stored for 4 to 10 years. Acceptable call rates for SNPs were detected for 7 of 42 archival samples. In conclusion, archival bone marrow samples are suitable for DNA extraction and multiple marker analysis, but WGA was less successful, especially when longer fragments were analyzed. Multiple SNP...

  7. FRACTURE NASAL BONES

    Directory of Open Access Journals (Sweden)

    Balasubramanian Thaigarajan

    2013-03-01

    Full Text Available Nose is the most prominent part of the face, hence it is likely to be the most common structure to be injured in the face. Although fractures involving the nasal bones are very common, it is often ignored by the patient. Patients with fractures of nasal bone will have deformity, tenderness, haemorrhage, edema, ecchymosis, instability, and crepitation. These features may be present in varying combinations. This article discusses the pathophysiology of these fractures, role of radiography and ultrasound in their diagnosis and their management.

  8. Computerized geometric features of carpal bone for bone age estimation

    Institute of Scientific and Technical Information of China (English)

    Chi-Wen Hsieh; Tai-Lang Jong; Yi-Hong Chou; Chui-Mei Tiu

    2007-01-01

    Background Bone age development is one of the significant indicators depicting the growth status of children.However, bone age assessment is an heuristic and tedious work for pediatricians. We developed a computerized bone age estimation system based on the analysis of geometric features of carpal bones.Methods The geometric features of carpals were extracted and analyzed to judge the bone age of children by computerized shape and area description. Four classifiers, linear, nearest neighbor, back-propagation neural network,and radial basis function neural network, were adopted to categorize bone age. Principal component and discriminate analyses were employed to improve assorting accuracy.Results The hand X-ray films of 465 boys and 444 girls served as our database. The features were extracted from carpal bone images, including shape, area, and sequence. The proposed normalization area ratio method was effective in bone age classification by simulation. Besides, features statistics showed similar results between the standard of the Greulich and Pyle atlas and our database.Conclusions The bone area has a higher discriminating power to judge bone age. The ossification sequence of trapezium and trapezoid bones between Taiwanese and the atlas of the GP method is quite different. These results also indicate that carpal bone assessment with classification of neural networks can be correct and practical.

  9. Accuracy evaluation of a new three-dimensional reproduction method of edentulous dental casts, and wax occlusion rims with jaw relation

    Institute of Scientific and Technical Information of China (English)

    Fu-Song Yuan; Yu-Chun Sun; Yong Wang; Pei-Jun Lu

    2013-01-01

    The article introduces a new method for three-dimensional reproduction of edentulous dental casts, and wax occlusion rims with jaw relation by using a commercial high-speed line laser scanner and reverse engineering software and evaluates the method’s accuracy in vitro. The method comprises three main steps:(i) acquisition of the three-dimensional stereolithography data of maxillary and mandibular edentulous dental casts and wax occlusion rims;(ii) acquisition of the three-dimensional stereolithography data of jaw relations;and (iii) registration of these data with the reverse engineering software and completing reconstruction. To evaluate the accuracy of this method, dental casts and wax occlusion rims of 10 edentulous patients were used. The lengths of eight lines between common anatomic landmarks were measured directly on the casts and occlusion rims by using a vernier caliper and on the three-dimensional computerized images by using the software measurement tool. The direct data were considered as the true values. The paired-samples t-test was used for statistical analysis. The mean differences between the direct and the computerized measurements were mostly less than 0.04 mm and were not significant (P.0.05). Statistical significance among 10 patients was assessed using one-way analysis of variance (P,0.05). The result showed that the 10 patients were considered statistically no significant. Therefore, accurate three-dimensional reproduction of the edentulous dental casts, wax occlusion rims, and jaw relations was achieved. The proposed method enables the visualization of occlusion from different views and would help to meet the demand for the computer-aided design of removable complete dentures.

  10. Er,Cr∶ YSGG激光备洞对老年人非龋性硬化牙本质微拉伸粘接强度的影响%Influence of Er, Cr∶YSGG Laser on the Microtensile Bond Strength of the Non-Carious Sclerotic Dentin of the Elderly

    Institute of Scientific and Technical Information of China (English)

    刘艳; 王洋; 贾兴亚

    2012-01-01

    Objective To evaluate the influence of Er, Cr: YSGG laser on the microtensile bond strength of the non-carious sclerotic dentin of the elderly, and compare the influence of two different filling materials on the bond strength. Methods Forty elderly premolars having wedge-shaped defects and typical sclerotic dentin on the surface were randomly divided into the experimental group and control group. The premolars in the experimental group were processed with Er, Cr: YSGG laser, and those in the control group with high-speed dental turbine handpiece. Each group was further divided into two subgroups, having composite resin or glass ionomer cement as filling agents. The teeth were stored in distilled water for 24 hours at 371C and then cut into dumbbell - shaped specimens approximating 1 mm in thickness. The microtensile bond strength was determined with Instron 5 848 Micro Tester. Then the morphological change of dentin surface was observed with SEM. Results n the experimental group, the microtensile bond strength stood at (35. 24 7.05) Mpa and (17.71 5. 74) Mpa respectively for the composite resin subgroup and glass ionomer cement subgroup. In the control group, it was (27. 56 4. 79) Mpa and (11.47 5. 12) Mpa respectively for the composite resin subgroup and glass ionomer cement subgroup. The difference of microtensile bond strength between the experimental group and control group was statistically significant (P < 0.05 ). Within either group, the difference of microtensile bond strength between the composite resin subgroup and glass ionomer cement subgroup was statistically significant (P < 0.05). Conclusions The elderly non - carious sclerotic dentin processed with Er, Cr: YSGG laser has higher bonding strength than that with high - speed dental turbine handpiece. Composite resin is greater than glass ionomer in bonding strength.%目的 评价Er,Cr∶ YSGG激光备洞对硬化牙本质微拉伸粘接强度的影响,并比较其对两种不同充填材

  11. Vitamin D, Calcium, and Bone Health

    Science.gov (United States)

    ... Balance › Vitamin D, Calcium, and Bone Health Vitamin D, Calcium, and Bone Health March 2012 Download PDFs ... helps keep your bones strong. Why are vitamin D and calcium important to bone health? Vitamin D ...

  12. Marijuana May Blunt Bone Health

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_161575.html Marijuana May Blunt Bone Health Study finds heavy users ... 19, 2016 WEDNESDAY, Oct. 19, 2016 (HealthDay News) -- Marijuana may be bad to the bone, a new ...

  13. Bone-marrow transplant - slideshow

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/presentations/100112.htm Bone-marrow transplant - series To use the sharing features on ... slide 4 out of 4 Normal anatomy Overview Bone-marrow is a soft, fatty tissue found inside of ...

  14. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... little information about muscles, tendons or joints. An MRI may be more useful in identifying bone and ... bones and the spinal cord can be evaluated). MRI can also detect subtle or occult fractures or ...

  15. Vitamin A and Bone Health

    Science.gov (United States)

    ... supported by your browser. Home Bone Basics Nutrition Vitamin A and Bone Health Publication available in: PDF ( ... Find More Information? For Your Information What Is Vitamin A? Vitamin A is a family of compounds ...

  16. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... your doctor to view and assess bone fractures, injuries and joint abnormalities. This exam requires little to ... fusion, joint replacement and fracture reductions. look for injury, infection, arthritis , abnormal bone growths and bony changes ...

  17. Exercise, lifestyle, and your bones

    Science.gov (United States)

    Osteoporosis - exercise; Low bone density - exercise; Osteopenia - exercise ... your bones strong and lower your risk of osteoporosis and fractures as you get older. Before you begin an exercise program, talk with your health care provider if: ...

  18. [Pharmacology of bone anabolic agents].

    Science.gov (United States)

    Matsumoto, Toshio

    2015-10-01

    Bone is constantly remodeled to maintain its volume, structural integrity and strength Currently available bone anabolic agent is teriparatide. Teriparatide increases bone mass and strength via both remodeling-dependent and -independent mechanisms, although remodeling-dependent mechanism overweighs the other. Canonical Wnt signal plays an important role in enhancing osteoblast differentiation and bone formation, and its osteocyte-derived inhibitor, sclerostin, regulates bone formation via the regulation of Wnt signaling. Anti-sclerostin antibody stimulates Wnt signaling and enhances bone formation. Phase II clinical trials with anti-sclerostin antibodies, romosozumab and blosozumab, demonstrated a marked increase in bone mineral density after one year of treatment. The new modality of anabolic agents via remodeling-independent stimulation of bone formation may open up a new avenue for the treatment of osteoporosis.

  19. Limb Salvage After Bone Cancer

    Science.gov (United States)

    ... Blog Donate Now Select Page Limb Salvage After Bone Cancer Home > Understanding Children’s Cancer > Late Effects of Treatment > Limb Salvage After Bone Cancer Limb salvage is a surgical procedure that replaces ...

  20. Drugs Approved for Bone Cancer

    Science.gov (United States)

    ... Ask about Your Treatment Research Drugs Approved for Bone Cancer This page lists cancer drugs approved by the ... that are not listed here. Drugs Approved for Bone Cancer Abitrexate (Methotrexate) Cosmegen (Dactinomycin) Dactinomycin Denosumab Doxorubicin Hydrochloride ...

  1. Bone Anchored Hearing Treatment Procedure

    Medline Plus

    Full Text Available ... The Baha system consists of a bone-anchored titanium fixture that is implanted in the mastoid bone, ... the -- great. I'm going to grab the titanium implant. And what I want you to notice ...

  2. Cellular and Molecular Mechanisms of Bone Remodeling*

    OpenAIRE

    Raggatt, Liza J; Partridge, Nicola C

    2010-01-01

    Physiological bone remodeling is a highly coordinated process responsible for bone resorption and formation and is necessary to repair damaged bone and to maintain mineral homeostasis. In addition to the traditional bone cells (osteoclasts, osteoblasts, and osteocytes) that are necessary for bone remodeling, several immune cells have also been implicated in bone disease. This minireview discusses physiological bone remodeling, outlining the traditional bone biology dogma in light of emerging ...

  3. Cancellous structure of tarsal bones.

    OpenAIRE

    D N Sinha

    1985-01-01

    The internal structure of the tarsal bones has been studied to investigate their cancellous architecture. It is revealed that these bones have fine and coarse meshworks and even a tendency for obliteration of the trabecular pattern in the bones lying distal to this midtarsal joint. Internal structure of the talus does not show an arched pattern of bony lamellae. An increased density of bony lamellae in the internal structure of the navicular bone could result from excessive stress, enforced b...

  4. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... Resources Professions Site Index A-Z X-ray (Radiography) - Bone Bone x-ray uses a very small ... X-ray (Radiography)? What is Bone X-ray (Radiography)? An x-ray (radiograph) is a noninvasive medical ...

  5. Breast Cancer and Bone Loss

    Science.gov (United States)

    ... Balance › Breast Cancer and Bone Loss Fact Sheet Breast Cancer and Bone Loss July, 2010 Download PDFs English ... JoAnn Pinkerton, MD What is the link between breast cancer and bone loss? Certain treatments for breast cancer ...

  6. Chondrosarcoma of the hyoid bone

    Energy Technology Data Exchange (ETDEWEB)

    Demeyere, A.; Somer, F. de; Perdieus, D.; Lemmens, L.; Schillebeeckx, J. [Dept. of Radiology, Imeldaziekenhuis Bonheiden (Belgium); Hauwe, L. van den [Dept. of Radiology, University Hospital Antwerp (Belgium)

    2000-02-01

    The CT and MRI findings in a case of chondrosarcoma of the hyoid bone are reported. Although chondrosarcoma is the second most common primary malignant bone tumor, only 10 % of chondrosarcomas occur in the head and neck region. The hyoid bone is a rare site of involvement with only seven cases reported previously. (orig.)

  7. Gout: Value of bone scanning

    Energy Technology Data Exchange (ETDEWEB)

    Oliva, J.P.; Cardenas, R.; Bell, L.; Gonzalez Griego, J.

    1986-12-01

    11 male patients with gout were studied by means of bone scintigraphy with /sup 99m/TcMDP. This diagnostic method rendered possible the diagnosis of clinically or roentgenologically occult bone involvement. Bone scintigraphy may be useful procedure to monitor therapy of gout.

  8. Bone vascularization: a way to study bone microarchitecture?

    Science.gov (United States)

    Blery, P.; Autrusseau, F.; Crauste, E.; Freuchet, Erwan; Weiss, Pierre; Guédon, J.-P.; Amouriq, Y.

    2014-03-01

    Trabecular bone and its microarchitecture are of prime importance for health. Studying vascularization helps to better know the relationship between bone and vascular microarchitecture. This research is an animal study (nine Lewis rats), based on the perfusion of vascularization by a contrast agent (a mixture of 50% barium sulfate with 1.5% of gelatin) before euthanasia. The samples were studied by micro CT at a resolution of 9μm. Softwares were used to show 3D volumes of bone and vessels, to calculate bone and vessels microarchitecture parameters. This study aims to understand simultaneously the bone microarchitecture and its vascular microarchitecture.

  9. Bone metastases: When and how lung cancer interacts with bone

    OpenAIRE

    Roato, Ilaria

    2014-01-01

    Bone metastasis is a common and debilitating consequence of lung cancer: 30%-40% of patients with non-small cell lung cancer develop bone metastases during the course of their disease. Lung cancer cells find a favorable soil in the bone microenvironment due to factors released by the bone matrix, the immune system cells, and the same cancer cells. Many aspects of the cross-talk among lung tumor cells, the immune system, and bone cells are not clear, but this review aims to summarize the recen...

  10. Intense ventilation of the Black Sea pycnocline due to vertical turbulent exchange in the Rim Current area

    Science.gov (United States)

    Ostrovskii, Alexander G.; Zatsepin, Andrey G.

    2016-10-01

    This paper presents new observational data, which indicate that deep ventilation events in the aerobic zone extending across the upper part of the permanent pycnocline may occur sporadically in the Rim Current area, even during relatively warm seasons, when the seasonal thermocline is still notable. The strongest observed event of this type occurred on November 2014 off the continental shelf break near Gelendzhik Bay. Vertical profiles of dissolved oxygen were accurately measured using an SBE 52-MP Conductivity, Temperature, Depth (CTD) probe equipped with a fast-response SBE 43F oxygen sensor mounted on a moored Aqualog automatic mobile profiler. The analysis of the profiling data from October 6 through December 16, 2014, from depths between 35 m and 215 m revealed an anomaly on November 6-7. The dissolved oxygen exceeded the background levels by more than 0.2 ml/l (8.9 μM) at the 14.9-15.7 kg/m3 isopycnals in the pycnocline and reached approximately 1 ml/l (44.66 μM) for short periods. The peak absolute value of the dissolved oxygen reached an exceptionally high value of approximately 0.3 ml/l (13.4 μM) at the 15.9 kg/m3 isopycnal. The ventilation event increased the temperature by 0.2 °C at depths of 120-160 m. The simultaneous observations of both the thermohaline stratification and the ocean currents suggest that the ventilation event was associated with the sinking of pycnocline waters in the near-bottom Ekman layer along the continental slope and intense vertical turbulent exchange in the Rim Current area near the continental slope. The ventilation of the pycnocline when the overlaying upper ocean is stably stratified sharply differs from the convection reaching the Cold Intermediate Layer during extensive cooling of the sea surface. Indications of such ventilation events were also found in the Aqualog mooring data archive from 2012.

  11. Healthy Bones Matter

    Science.gov (United States)

    ... think that this is something that only older people need to worry about. BUT—you can take action right now to help make sure that as you get older your bones are as healthy as they can be. Eating a balanced diet ...

  12. Temporal bone imaging

    Energy Technology Data Exchange (ETDEWEB)

    Lemmerling, Marc [Algemeen Ziekenhuis Sint-Lucas, Gent (Belgium). Dept. of Radiology; Foer, Bert de (ed.) [Sint-Augustinus Ziekenhuis, Wilrijk (Belgium). Dept. of Radiology

    2015-04-01

    Complete overview of imaging of normal and diseased temporal bone. Straightforward structure to facilitate learning. Detailed consideration of newer imaging techniques, including the hot topic of diffusion-weighted imaging. Includes a chapter on anatomy that will be of great help to the novice interpreter of imaging findings. Excellent illustrations throughout. This book provides a complete overview of imaging of normal and diseased temporal bone. After description of indications for imaging and the cross-sectional imaging anatomy of the area, subsequent chapters address the various diseases and conditions that affect the temporal bone and are likely to be encountered regularly in clinical practice. The classic imaging methods are described and discussed in detail, and individual chapters are included on newer techniques such as functional imaging and diffusion-weighted imaging. There is also a strong focus on postoperative imaging. Throughout, imaging findings are documented with the aid of numerous informative, high-quality illustrations. Temporal Bone Imaging, with its straightforward structure based essentially on topography, will prove of immense value in daily practice.

  13. Bone Marrow Matters

    Science.gov (United States)

    Dunne, Mark; Maklad, Rania; Heaney, Emma

    2014-01-01

    As a final-year student teacher specialising in primary science, Emma Heaney faced the challenge of having to plan, organise, and conduct a small-scale, classroom-based research project. She had to teach about bones in the final block practice session and thought it would be a good idea to bring in some biological specimens obtained from the local…

  14. Are Bones Alive?

    Science.gov (United States)

    Caravita, Silvia; Falchetti, Elisabetta

    2005-01-01

    Many studies have investigated the classification of living things. Our study deals with a different problem: the attribution of life to one component of a living organism, specifically the bones. The task involves not only specifying what we mean by "alive", but also requires "informed thinking" leading to an understanding of the concept of life…

  15. Bone scintigraphy in chondroblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Humphry, A.; Gilday, D.L.; Brown, R.G.

    1980-11-01

    Scintigraphy in 3 patients with chondroblastoma showed that the tumors were hyperemic and avidly accumulated the radionuclide. These changes were also present in adjacent normal bone, but to a lesser degree. This suggests that radionuclide uptake in chondroblastoma is a function of the blood supply to the tumor rather than primary matrix extraction.

  16. Chondroblastoma of temporal bone

    Energy Technology Data Exchange (ETDEWEB)

    Tanohta, K.; Noda, M.; Katoh, H.; Okazaki, A.; Sugiyama, S.; Maehara, T.; Onishi, S.; Tanida, T.

    1986-07-01

    The case of a 55-year-old female with chondroblastoma arising from the left temporal bone is presented. Although 10 cases of temporal chondroblastoma have been reported, this is the first in which plain radiography, pluridirectional tomography, computed tomography (CT) and angiography were performed. We discuss the clinical and radiological aspects of this rare tumor.

  17. Metastatic Bone Disease

    Science.gov (United States)

    ... concern for patients with MBD is the general loss in quality of life. How much of an effect MBD has on ... to be most effective in maintaining quality of life. A technetium bone scan ... blood count, because loss of red blood cells (anemia) is a frequent ...

  18. Bone island and leprosy

    International Nuclear Information System (INIS)

    Objective. To determine the incidence of bone islands in leprosy patients. Design. X-rays of feet and hands of patients with Hansen's disease (leprosy) were reviewed retrospectively. A second group of related age- and sex-matched patients who did not have Hansen's disease was used for control purposes. Controls had undergone hand or foot X-rays during diagnosis of other pathologies. The patients with Hansen's disease were compared with the control group, and were also analyzed as subgroups with different types of leprosy. The results were subjected to statistical analysis. Patients. Ninety patients with Hansen's disease were randomly selected for this study. Patients who had had ulcers on hands or feet were excluded from the study. Results and conclusions. Bone islands were demonstrated in 20 patients with Hansen's disease; no bone islands were observed in the controls. This was statistically significant (P<0.01). Bone islands were only seen in patients with lepromatous leprosy and borderline types but were not demonstrated in patients with tuberculoid leprosy. There was also a statistically significant relationship for a disease duration of 15 years or more. The cause of this raised incidence of enostosis in leprosy patients is not clear, but there may be a genetic predisposition in patients with leprosy, or it may be a side effect of leprosy, especially the lepromatous form. (orig.)

  19. Food and Your Bones

    Science.gov (United States)

    ... Store Shopping Cart Home › Patients › Treatment › Nutrition Nutrition Food For Thought Quiz True or false: Prunes contain ... health. True False View Answers Loading ... Sponsored by: Food and Your Bones – Osteoporosis Nutrition Guidelines The food ...

  20. Sodium and bone health

    DEFF Research Database (Denmark)

    Teucher, B.; Dainty, J. R.; Spinks, C. A.;

    2008-01-01

    High salt intake is a well-recognized risk factor for osteoporosis because it induces calciuria, but the effects of salt on calcium metabolism and the potential impact on bone health in postmenopausal women have not been fully characterized. This study investigated adaptive mechanisms in response...

  1. Bone scintigraphy in psoriasis

    Energy Technology Data Exchange (ETDEWEB)

    Hahn, K.; Thiers, G.; Eissner, D.; Holzmann, H.

    1980-08-01

    Since 1973 bone scintigraphy using sup(99m)Tc-phosphate-complexes was carried out in 382 patients with psoriasis. For comparison with the results of nuclear medicine, roentgenologic and clinical findings a group af 121 patients with psoriasis aged between 11 and 74 years was compared to a group of 42 patients aged between 20 and 49 years without roentgenologic and clinical signs of psoriasis arthritis. We found by means of isotope investigation that an essentially greater part of the bones adjacent to the joints was involved than was expected according to X-ray and clinical findings. In addition, in 205 patients with psoriasis whole-body scintigraphy, using sup(99m)Tc-MDP, was carried out since 1977/78. In 17 patients we found an increased accumulation of activity in the region of extraarticular structures of the skull as well as of the skeletal thorax. According to these results we conclude that in addition to the clinically and roentgenologically defined psoriatic arthritis in patients with psoriasis an osteopathy may exist, which can only be demonstrated by skeletal scintigraphy and which is localized in bones adjacent to the joints but can also be demonstrated in the region of extraarticular bones.

  2. [Metabolic bone disease osteomalacia].

    Science.gov (United States)

    Reuss-Borst, M A

    2014-05-01

    Osteomalacia is a rare disorder of bone metabolism leading to reduced bone mineralization. Underlying vitamin D deficiency and a disturbed phosphate metabolism (so-called hypophosphatemic osteomalacia) can cause the disease. Leading symptoms are dull localized or generalized bone pain, muscle weakness and cramps as well as increased incidence of falls. Rheumatic diseases, such as polymyalgia rheumatica, rheumatoid arthritis, myositis and fibromyalgia must be considered in the differential diagnosis. Alkaline phosphatase (AP) is typically elevated in osteomalacia while serum phosphate and/or 25-OH vitamin D3 levels are reduced. The diagnosis of osteomalacia can be confirmed by an iliac crest bone biopsy. Histological correlate is reduced or deficient mineralization of the newly synthesized extracellular matrix. Treatment strategies comprise supplementation of vitamin D and calcium and for patients with intestinal malabsorption syndromes vitamin D and calcium are also given parenterally. In renal phosphate wasting syndromes substitution of phosphate is the treatment of choice, except for tumor-induced osteomalacia when removal of the tumor leads to a cure in most cases. PMID:24811356

  3. Super bone scans on bone scintigraphy in patients with metastatic bone tumor

    International Nuclear Information System (INIS)

    Eight patients with malignant tumor (3 with gastric cancer, 4 with prostatic cancer, 1 with transitional cell carcinoma), which showed diffusely increased uptake of 99mTc labelled phosphorous compound in axial skeleton (''Super Bone Scan'') on bone scintigraphy were clinically studied. No relationship with its histological type of the tumor was recognized. All cases revealed extremely high serum ALP concentration, which might reflect increased osteoblastic activity. Furthermore, on bone roentgenograms all cases showed predominantly osteosclerotic change in the metastatic bones, while some did locally osteolytic change. In three cases with gastric cancer, although they had diffuse skeletal metastases, two had no evidence of liver metastases. Thus, it seemed that clinical study of patients with ''Super Bone Scan'' was interesting to evaluate the mechanism of accumulation of 99mTc labelled phosphorous compound to bone and bone metabolism, and the pathophysiology in the pathway of bone metastases. (author)

  4. Combined bone grafting: an alternative method for bone healing stimulation

    International Nuclear Information System (INIS)

    The most provocative problem in bone grafting is the effectiveness of healing of the graft. When you use the heterogenous bone graft, it may take one or more than two years for consolidation and union depends on the graft quality and the situation of surrounding blood supply. In our preliminary report seven cases of freeze-dried heterogenous bone graft from the Bangkok Biomaterial Center were mixed with autogenous iliac bone graft from the patient in the ratio of 3:1. After that the healing was checked by clinical examination and X-ray in the periodic follow up. The causes of bone lost are post evacuation of benign bone tumor and post infection of bone after trauma. The result of bony union could be tested by clinical examination and showed in the X-ray films as early as 3 months post grafting

  5. Bone marrow oedema associated with benign and malignant bone tumours

    Energy Technology Data Exchange (ETDEWEB)

    James, S.L.J. [Department of Radiology, Royal Orthopaedic Hospital, Birmingham, B31 2AP (United Kingdom)], E-mail: steven.james@roh.nhs.uk; Panicek, D.M. [Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021 (United States); Davies, A.M. [Department of Radiology, Royal Orthopaedic Hospital, Birmingham, B31 2AP (United Kingdom)

    2008-07-15

    Bone marrow oedema is associated with a wide variety of pathological processes including both benign and malignant bone tumours. This imaging finding in relation to intraosseous tumours can aid in providing a more focused differential diagnosis. In this review, we will discuss the MR imaging of bone marrow oedema surrounding intraosseous neoplasms. The different pulse sequences used in differentiating underlying tumour from surrounding oedema are discussed along with the role of dynamic contrast enhanced MRI. Benign lesions commonly associated with bone marrow oedema include osteoid osteoma, osteoblastoma, chondroblastoma and Langerhan's cell histiocytosis. Metastases and malignant primary bone tumours such as osteosarcoma, Ewing's sarcoma and chondrosarcoma may also be surrounded by bone marrow oedema. The imaging findings of these conditions are reviewed and illustrated. Finally, the importance of bone marrow oedema in assessment of post chemotherapeutic response is addressed.

  6. A Large Number of Hα Emission Stars and Herbig-Haro Objects in and around Bright-Rimmed Clouds

    Science.gov (United States)

    Ogura, K.; Sugitani, K.

    We present the results of our Hα grism spectroscopy and narrow-band imaging observations of bright-rimmed clouds (BRCs) in search of candidate pre-main sequence stars of the T Tauri, Herbig Ae/Be and related types, and of Herbig-Haro (HH) objects. We have detected altogether 460 Hα emission stars down to about R = 20, around all but two of the 28 BRCs observed. The present study has, for the first time, reached down nearly to the faintest classical T Tauri stars in OB associations. Twelve new HH objects have also been found. Most are of small apparent size, emphasizing the need for deep searches at high spatial resolution. These stars and HH objects are concentrated near the tip of BRCs, thus supporting our hypothesis of ``small-scale sequential star formation''. The presence of such a large number of Hα emission stars around BRCs implies that second-generation formation of low-mass stars in HII regions is relatively extensive, and further supports the notion of cohabitation of high- and low-mass populations in OB associations.

  7. Infecção gonocócica em rim carcinomatoso Gonococcal infection in carcinomatous kidney

    Directory of Open Access Journals (Sweden)

    Jorge de Gouvêa

    1939-01-01

    Full Text Available Os A.A. observaram um caso de infecção renal gonocócica, que relatam com as necessarias minucias, tanto sob o ponto de vista clinico-cirurgico como bacteriologico. 2 - Revendo a bibliografia sobre o assunto, verificaram que as infecções renais gonocócias são raras, e rarissimas as que apresentam provas de identificação bacteriologica completa do gonocóco, como se fez no presente caso que deve figurar em 15º lugar, desde a descoberta do germen por Neisser, ha 59 anos. 3 - As provas bacteriologicas consistiram no exame bacterioscopico do sedimento urinario e pús renal, caracteres das colonias e culturas, seguidas de exames de esfregaços, provas de fermentação de glicose e maltose; sôro aglutinação e gono fixação. Todas as provas foram positivas para o gonocóco. 4- O rim não deve ser favoravel á proliferação do gonocóco, ou pela natureza do seu epitelio ou pela secreção de substancias que impeçam o seu desenvolvimento ou outra causa qualquer. Dada a frequencia das infecções gonocócicas no parelho urinario inferior, seria de esperar que, em grande numero de casos, fosse atingido o superior.5 - Como causas predisponentes a esse ataque secundario que se processa por vias sanguinea, linfatica ou contiguidade, cita Uhle as seguintes: 1º - perturbações congenitas, lesões obstrutoras, principalmente do ureter. 2º - calculos, tumores, etc. 3º - traumatismos seguidos de rutura e hemorragia e 4º - antecedentes patologícos não demonstrados. O nosso caso cabe no 2º paragrafo. O rim apresentava um tumor maligno e tinha inumeros calculos. 6 - Depois que o rim foi retirado pela intervenção cirurgica, que correu sem acidentes, o doente entrou logo a melhorar, tendo alta curado, do Hospital. Nada tem havido, até a presente data, que faça suspeitar, no desenvolvimento de qualquer metastase do tumor. Aliás, a operação foi indicada em virtude do estado infeccioso, sendo posterior á mesma a descoberta do carcinoma. 7

  8. A new conceptual model for quantifying transboundary contribution of atmospheric pollutants in the East Asian Pacific rim region.

    Science.gov (United States)

    Lai, I-Chien; Lee, Chon-Lin; Huang, Hu-Ching

    2016-03-01

    Transboundary transport of air pollution is a serious environmental concern as pollutant affects both human health and the environment. Many numerical approaches have been utilized to quantify the amounts of pollutants transported to receptor regions, based on emission inventories from possible source regions. However, sparse temporal-spatial observational data and uncertainty in emission inventories might make the transboundary transport contribution difficult to estimate. This study presents a conceptual quantitative approach that uses transport pathway classification in combination with curve fitting models to simulate an air pollutant concentration baseline for pollution background concentrations. This approach is used to investigate the transboundary transport contribution of atmospheric pollutants to a metropolitan area in the East Asian Pacific rim region. Trajectory analysis categorized pollution sources for the study area into three regions: East Asia, Southeast Asia, and Taiwan cities. The occurrence frequency and transboundary contribution results suggest the predominant source region is the East Asian continent. This study also presents an application to evaluate heavy pollution cases for health concerns. This new baseline construction model provides a useful tool for the study of the contribution of transboundary pollution delivered to receptors, especially for areas deficient in emission inventories and regulatory monitoring data for harmful air pollutants. PMID:26760713

  9. Geochemical analysis of atlantic rim water, carbon county, wyoming: New applications for characterizing coalbed natural gas reservoirs

    Science.gov (United States)

    McLaughlin, J.F.; Frost, C.D.; Sharma, S.

    2011-01-01

    Coalbed natural gas (CBNG) production typically requires the extraction of large volumes of water from target formations, thereby influencing any associated reservoir systems. We describe isotopic tracers that provide immediate data on the presence or absence of biogenic natural gas and the identify methane-containing reservoirs are hydrologically confined. Isotopes of dissolved inorganic carbon and strontium, along with water quality data, were used to characterize the CBNG reservoirs and hydrogeologic systems of Wyoming's Atlantic Rim. Water was analyzed from a stream, springs, and CBNG wells. Strontium isotopic composition and major ion geochemistry identify two groups of surface water samples. Muddy Creek and Mesaverde Group spring samples are Ca-Mg-S04-type water with higher 87Sr/86Sr, reflecting relatively young groundwater recharged from precipitation in the Sierra Madre. Groundwaters emitted from the Lewis Shale springs are Na-HCO3-type waters with lower 87Sr/86Sr, reflecting sulfate reduction and more extensive water-rock interaction. To distinguish coalbed waters, methanogenically enriched ??13CDIC wasused from other natural waters. Enriched ??13CDIC, between -3.6 and +13.3???, identified spring water that likely originates from Mesaverde coalbed reservoirs. Strongly positive ??13CDIC, between +12.6 and +22.8???, identified those coalbed reservoirs that are confined, whereas lower ??13CDIC, between +0.0 and +9.9???, identified wells within unconfined reservoir systems. Copyright ?? 2011. The American Association of Petroleum Geologists. All rights reserved.

  10. Effect of biomass burning over the western North Pacific Rim: wintertime maxima of anhydrosugars in ambient aerosols from Okinawa

    Science.gov (United States)

    Zhu, C.; Kawamura, K.; Kunwar, B.

    2015-02-01

    Biomass burning (BB) largely modifies the chemical composition of atmospheric aerosols on the globe. We collected aerosol samples (TSP) at Cape Hedo, on subtropical Okinawa Island, from October 2009 to February 2012 to study anhydrosugars as BB tracers. Levoglucosan was detected as the dominant anhydrosugar followed by its isomers, mannosan and galactosan. We found a clear seasonal trend of levoglucosan and mannosan with winter maxima and summer minima. Positive correlation was found between levoglucosan and nss-K+ (r = 0.38, p levoglucosan / mannosan ratios were lower (2.1-4.8) in May-June and higher (13.3-13.9) in November-December. The lower values may be associated with softwood burning in northern China, Korea and southwestern Japan whereas the higher values are probably caused by agricultural waste burning of maize straw in the North China Plain. Anhydrosugars comprised 0.22% of water-soluble organic carbon (WSOC) and 0.13% of organic carbon (OC). The highest values to WSOC (0.37%) and OC (0.25%) were found in winter, again indicating an important BB contribution to Okinawa aerosols in winter. This study provides useful information to better understand the effect of East Asian biomass burning on the air quality in the western North Pacific Rim.

  11. A new conceptual model for quantifying transboundary contribution of atmospheric pollutants in the East Asian Pacific rim region.

    Science.gov (United States)

    Lai, I-Chien; Lee, Chon-Lin; Huang, Hu-Ching

    2016-03-01

    Transboundary transport of air pollution is a serious environmental concern as pollutant affects both human health and the environment. Many numerical approaches have been utilized to quantify the amounts of pollutants transported to receptor regions, based on emission inventories from possible source regions. However, sparse temporal-spatial observational data and uncertainty in emission inventories might make the transboundary transport contribution difficult to estimate. This study presents a conceptual quantitative approach that uses transport pathway classification in combination with curve fitting models to simulate an air pollutant concentration baseline for pollution background concentrations. This approach is used to investigate the transboundary transport contribution of atmospheric pollutants to a metropolitan area in the East Asian Pacific rim region. Trajectory analysis categorized pollution sources for the study area into three regions: East Asia, Southeast Asia, and Taiwan cities. The occurrence frequency and transboundary contribution results suggest the predominant source region is the East Asian continent. This study also presents an application to evaluate heavy pollution cases for health concerns. This new baseline construction model provides a useful tool for the study of the contribution of transboundary pollution delivered to receptors, especially for areas deficient in emission inventories and regulatory monitoring data for harmful air pollutants.

  12. VizieR Online Data Catalog: Photometry of YSOs in eight bright-rimmed clouds (Sharma+, 2016)

    Science.gov (United States)

    Sharma, S.; Pandey, A. K.; Borissova, J.; Ojha, D. K.; Ivanov, V. D.; Ogura, K.; Kobayashi, N.; Kurtev, R.; Gopinathan, M.; Yadav, R. K.

    2016-08-01

    Near-infrared (J, H, K') data for eight selected Bright-Rimmed Clouds (BRCs) along with two nearby field regions (see Table1) were collected with the Infrared Side Port Imager (ISPI) camera (FOV~10.5*10.5arcmin2; scale 0.3arcsec/pixel) on the 4m Blanco telescope at Cerro Tololo Inter-American Observatory (CTIO), Chile, during the nights of 2010 March 03-04. The seeing was ~1arcsec. The individual exposure times were 60 s per frame for all filters. The total exposure time for the target fields was 540s for each J, H, and K' band. We also used the infrared archived data taken from the Infrared Array Camera (IRAC) of the space-based Spitzer telescope at the 3.6, 4.5, 5.8, and 8.0μm bands. We obtained Basic Calibrated Data (BCD) from the Spitzer data archive for all BRCs (except SFO 76, which has no Spitzer data). The exposure time of each BCD was 10.4s (4 data files).

  13. Regional multi-compartment ecological risk assessment: Establishing cadmium pollution risk in the northern Bohai Rim, China.

    Science.gov (United States)

    Shi, Yajuan; Wang, Ruoshi; Lu, Yonglong; Song, Shuai; Johnson, Andrew C; Sweetman, Andrew; Jones, Kevin

    2016-09-01

    Ecological risk assessment (ERA) has been widely applied in characterizing the risk of chemicals to organisms and ecosystems. The paucity of toxicity data on local biota living in the different compartments of an ecosystem and the absence of a suitable methodology for multi-compartment spatial risk assessment at the regional scale has held back this field. The major objective of this study was to develop a methodology to quantify and distinguish the spatial distribution of risk to ecosystems at a regional scale. A framework for regional multi-compartment probabilistic ecological risk assessment (RMPERA) was constructed and corroborated using a bioassay of a local species. The risks from cadmium (Cd) pollution in river water, river sediment, coastal water, coastal surface sediment and soil in northern Bohai Rim were examined. The results indicated that the local organisms in soil, river, coastal water, and coastal sediment were affected by Cd. The greatest impacts from Cd were identified in the Tianjin and Huludao areas. The overall multi-compartment risk was 31.4% in the region. The methodology provides a new approach for regional multi-compartment ecological risk assessment. PMID:27286039

  14. Shoe rim and shoe buckle pseudotumor of the ankle in elite and professional figure skaters and snowboarders: MR imaging findings

    International Nuclear Information System (INIS)

    To review MR imaging of figure skaters and snowboarders presenting with painful soft-tissue swelling of the lateral supramalleolar region with a clinical provisional diagnosis of soft-tissue tumor. MR imaging was prospectively reviewed by two sub-specialized musculoskeletal radiologists. The findings were correlated with a second clinical review and examination of the shoe wear. The patients were four female athletes undergoing heavy training regimes, ranging in age between 16 and 25 years. Two patients were elite figure skaters, and two were professional snowboarders. Three patients had unilateral masses with pain, and one patient presented with bilateral clinical findings. MR imaging showed subcutaneous, focal soft-tissue masses of the supramalleolar region in five ankles at the same level above the ankle joint. MR imaging prompted a second clinical review and correlation with the shoe wear. The MR imaging findings correlated to the level of the shoe rim or shoe buckle in all patients, confirming the suspected MR imaging diagnosis of an impingement syndrome. All four sportswomen were training excessively, ignoring safety advice regarding training duration, timing of breaks, and shoe wear rotation. (orig.)

  15. Synoptic changes in the deep rim current during stagnant hydrographic conditions in the Eastern Gotland Basin, Baltic Sea

    Directory of Open Access Journals (Sweden)

    Eberhard Hagen

    2007-06-01

    Full Text Available Hydrographic and current measurements are analysed for stagnantdeep-water conditions over the south-eastern topographic flankof the Eastern Gotland Basin (EGB in April 2000.Results suggest a prevailing barotropic motion mode on a synopticscale of several days. Deep along-slope volume transports derivedfrom subsurface current meter moorings are compared with thoseof the baroclinic fraction of geostrophic motions crossing theplane of a hydrographic section. This was aligned perpendicularto deep isobaths and was repeated 40 times with a time step ofsix hours. Changes in regional winds produced a quasi-ten daycycle in the filling level of the Baltic Proper. Associated wave-likefluctuations of the mass field propagated cyclonically with avelocity of about 0.04 m s-1 around the deep basin's rim. Itis concluded that associated changes in deep volume transportsresult mainly from barotropically governed advection processesand that those of the baroclinic component of geostrophic currentsprovide a qualitatively and quantitatively quite inaccurate descriptionof related transport fluctuations on a daily scale.

  16. The mesangial matrix in the normal and sclerotic glomerulus.

    Science.gov (United States)

    Rosenblum, N D

    1994-02-01

    Mesangial sclerosis is a final common pathway to glomerular destruction in a variety of glomerular diseases. The expression of several classes of extracellular matrix (ECM) molecules has been defined in the normal and diseased mesangial matrix (MM). However, the manner in which these ECM components determine the three dimensional structure and function of the MM remains to be defined. Structural studies of the MM suggest that its constituent molecules are regionally organized into subcompartments with different three dimensional structures. The diversity of matrix molecules expressed within the MM as well as the organization of these components in nonrenal ECM's, such as the cornea, provides further support for this organizational model. The study of the cornea has also revealed that novel short chain collagenous proteins partially determine the three dimensional structure of the matrix. Recently, a novel collagen, type VIII collagen, has been described in mesangial cells and in the intact glomerulus. It is hypothesized that type VIII collagen is expressed both as a polymer and as a monomer within the glomerulus, and depending on its conformation, may serve unique functions. In the chronically diseased MM, normal MM components are overexpressed and fibrillar collagens are expressed de novo in a delayed fashion. Enhanced proteoglycan expression, observed early in disease, may determine increased volume of the mesangium. This, in turn, may stimulate the production of fibrillar collagens by mesangial cells resulting in a fibrillar noncompliant mesangial matrix.

  17. Function of osteocytes in bone.

    Science.gov (United States)

    Aarden, E M; Burger, E H; Nijweide, P J

    1994-07-01

    Although the structural design of cellular bone (i.e., bone containing osteocytes that are regularly spaced throughout the bone matrix) dates back to the first occurrence of bone as a tissue in evolution, and although osteocytes represent the most abundant cell type of bone, we know as yet little about the role of the osteocyte in bone metabolism. Osteocytes descend from osteoblasts. They are formed by the incorporation of osteoblasts into the bone matrix. Osteocytes remain in contact with each other and with cells on the bone surface via gap junction-coupled cell processes passing through the matrix via small channels, the canaliculi, that connect the cell body-containing lacunae with each other and with the outside world. During differentiation from osteoblasts to mature osteocyte the cells lose a large part of their cell organelles. Their cell processes are packed with microfilaments. In this review we discuss the various theories on osteocyte function that have taken in consideration these special features of osteocytes. These are 1) osteocytes are actively involved in bone turnover; 2) the osteocyte network is through its large cell-matrix contact surface involved in ion exchange; and 3) osteocytes are the mechanosensory cells of bone and play a pivotal role in functional adaptation of bone. In our opinion, especially the last theory offers an exciting concept for which some biomechanical, biochemical, and cell biological evidence is already available and which fully warrants further investigations.

  18. Differential diagnosis between odontogenic keratocyst and ameloblastoma by computed tomography

    International Nuclear Information System (INIS)

    The objective of this study is to find the differentiating characteristics of ameloblastomas and odontogenic keratocysts of the jaw by analyzing computed tomography (CT) images of the lesions, clarify radiological characteristics associated with jaw lesions, and to make a diagnosis based on these findings. Test subjects were chosen among the patients who were diagnosed as having an odontogenic keratocyst or ameloblastoma at the Yonsei University Dental Hospital from January 1996 to December 2000 and had CT scans taken preoperatively. The subject pool was comprised of 51 cases of odontogenic keratocyst and 37 cases of ameloblastoma. The following measures were used for image analysis of the lesion : the anatomic location, CT pattern, mesiodistal width, buccolingual width, the ratios between mesiodistal width and buccolingual width, height, CT number, homogeneity of radiodensity, the appearance of a sclerotic rim, continuity of adjacent cortical bone, and displacement and resorption of adjacent teeth. Comparing the CT patten, mesiodistal width, buccolingual width, height, CT number, homogeneity, appearance of sclerotic rim, continuity of adjacent cortical bone, there were statistically significant differences between ameloblastoma and odontogenic keratocyst test subjects (p0.05). We compared odontogenic keratocysts and ameloblastomas in CT scans. They occurred most frequently in the posterior to the ramus of the mandible. The findings of patterns of the CT images showed that size and border of lesions were more aggressive in ameloblastomas than in odontogenic keratocysts. The internal contents represented an increased attenuation area (IAA) in odontopenic keratocyst. Odontogenic keratocysts were shown to have higher CT numbers than ameloblastomas.

  19. Influence of bone environment on ceramic osteointegration in spinal fusion: comparison of bone-poor and bone-rich sites

    OpenAIRE

    Delécrin, Joël; Deschamps, Cédric; Romih, Mostafa; Heymann, Dominique; Passuti, Norbert

    2001-01-01

    Quantitative experimental data showed differences in bone quality and ceramic incorporation between bone-rich and bone-poor implantation sites. Bone in-growth was significantly lower for ceramic implanted at a lumbar intertransverse than a laminar site. Bone-marrow enrichment of the lumbar intertransverse site (regarded as bone-poor) greatly facilitated ceramic osteointegration. The vertebral interbody site, despite theoretical richness in osteogenic precursor cells, might be bone-poor at the...

  20. Bone- and bone marrow scintigraphy in Gaucher disease type 1

    Energy Technology Data Exchange (ETDEWEB)

    Mikosch, P. [Dept. of Nuclear Medicine and Endocrinology, State Hospital Klagenfurt (Austria); Dept. of Internal Medicine II, State Hospital Klagenfurt (Austria); Zitter, F. [Dept. of Internal Medicine II, State Hospital Klagenfurt (Austria); Gallowitsch, H.J.; Lind, P. [Dept. of Nuclear Medicine and Endocrinology, State Hospital Klagenfurt (Austria); Wuertz, F. [Dept. of Pathology, State Hospital Klagenfurt (Austria); Mehta, A.B.; Hughes, D.A. [Lysosomal Storage Disorder Unit, Dept. of Academic Haematology, Royal Free and Univ. Coll. Medical School, London (United Kingdom)

    2008-07-01

    Scintigraphy is a method for imaging metabolism and should be viewed as complimentary to morphological imaging. Bone and bone marrow scintigraphy can particularly contribute to the detection of focal disease in Gaucher disease. In bone crises it can discriminate within three days after pain onset between local infection and aseptic necrosis. A further advantage of bone- and bone marrow scintigraphy is the visualization of the whole skeleton within one setting. Whole body imaging for focal lesions might thus be an objective in GD, in particular in patients complaining of several painful sites. Direct imaging of bone marrow deposits in GD by MIBI scintigraphy might be of special interest in children in whom bone marrow undergoes a developmental conversion from red to yellow marrow in the ap-pendicular skeleton. MRI interpretation in young GD patients is thus difficult in order to estimate the exact amount and extent of bone marrow infiltration by Gaucher cells. 99mTc-MIBI scintigraphy with its direct visualization of lipid storage could thus add interesting additional information not shown with other methods including MRI. Although MRI is the most accepted imaging modality in assessing the skeletal status in GD, a selective use of scintigraphy for imaging bone and bone marrow may add information in the evaluation of patients with Gaucher disease.

  1. Temporal Bone Localized Chondroblastoma.

    Science.gov (United States)

    Demirhan, Hasan; Acioğlu, Engin; Durna, Yusuf Muhammed; Yiğit, Özgür; Bozkurt, Erol Rüştü; Karagöz, Yeşim

    2015-11-01

    Chondroblastoma is a highly destructive tumor originating from immature cartilage cells. Although chondroblastoma is defined as a benign tumor, it may exhibit malign tumor behaviors such as invasion or metastasis on neighboring structures. Magnetic resonance (MR) image is a solid mass lesion, which included heterogeneous hypointense in T2A and heterogeneous minimal hyperintense in T1A with destructive expansile characteristics and millimetric calcifications. Temporal bone chondroblastomas may complicate the diagnosis because of their different histologic characteristics. Microscopically, chondroblastic cell nests and calcification of locally "chicken wire" type around the cells are observed. These tumors secrete s-100 and vimentin and are used for differential diagnosis. In this study, a temporal bone localized chondroblastoma case is presented. PMID:26517458

  2. Temporal Bone Localized Chondroblastoma.

    Science.gov (United States)

    Demirhan, Hasan; Acioğlu, Engin; Durna, Yusuf Muhammed; Yiğit, Özgür; Bozkurt, Erol Rüştü; Karagöz, Yeşim

    2015-11-01

    Chondroblastoma is a highly destructive tumor originating from immature cartilage cells. Although chondroblastoma is defined as a benign tumor, it may exhibit malign tumor behaviors such as invasion or metastasis on neighboring structures. Magnetic resonance (MR) image is a solid mass lesion, which included heterogeneous hypointense in T2A and heterogeneous minimal hyperintense in T1A with destructive expansile characteristics and millimetric calcifications. Temporal bone chondroblastomas may complicate the diagnosis because of their different histologic characteristics. Microscopically, chondroblastic cell nests and calcification of locally "chicken wire" type around the cells are observed. These tumors secrete s-100 and vimentin and are used for differential diagnosis. In this study, a temporal bone localized chondroblastoma case is presented.

  3. [Fractures of carpal bones].

    Science.gov (United States)

    Lögters, T; Windolf, J

    2016-10-01

    Fractures of the carpal bones are uncommon. On standard radiographs fractures are often not recognized and a computed tomography (CT) scan is the diagnostic method of choice. The aim of treatment is to restore pain-free and full functioning of the hand. A distinction is made between stable and unstable carpal fractures. Stable non-displaced fractures can be treated conservatively. Unstable and displaced fractures have an increased risk of arthritis and non-union and should be stabilized by screws or k‑wires. If treated adequately, fractures of the carpal bones have a good prognosis. Unstable and dislocated fractures have an increased risk for non-union. The subsequent development of carpal collapse with arthrosis is a severe consequence of non-union, which has a heterogeneous prognosis.

  4. Computed tomography assessment of bone lesions in patients with POEMS syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Glazebrook, K.; Johnson, Adam; Leng, S.; Dispenzieri, A. [Mayo Clinic, Rochester, MN (United States); Guerra Bonilla, Francis L. [Hospital Regional Rafael Hernandez, Hematology Division, David, Chiriqui (Panama)

    2014-09-25

    To describe the imaging findings on computed tomography (CT) and skeletal survey (SS) in patients with POEMS syndrome. We retrospectively reviewed, with institutional review board approval, the dysproteinemia database at our institution for patients with new diagnosis of POEMS syndrome between January 1998 and December 2008. Twenty-four patients were identified with PET/CT or CT and had skeletal survey (SS) available for review. Twenty-four patients were included in the study group with median age of 47 years. All CTs demonstrated at least one sclerotic lesion. The most common pattern was multiple small lesions, with 18 patients (75 %) having at least 5 lesions less than 1 cm. The larger lesions had a central lytic component and were FDG avid. SS had a false negative rate of 36 % (8 patients). Serial CT after treatment showed a decrease in size and number of sclerotic lesions in 53 % of cases (13 patients), the majority showing increased sclerosis. Two patients had complete resolution of sclerotic lesions. CT identified sclerotic lesions in all study patients with POEMS syndrome, the majority being less than 1 cm in size, which were not identified radiographically. CT may demonstrate increased sclerosis or even resolution of sclerotic lesions corresponding to treatment response. (orig.)

  5. Dynamic scintigraphy of bone and bone marrow in multiple myeloma patients with bone-marrow transplants

    International Nuclear Information System (INIS)

    Purpose: To determine whether dynamic registration at bone and bone-marrow scintigraphy produces additional information compared to subsequent static registrations of bone-marrow transplants in multiple myeloma patients. Material and Methods: In a prospective study, 8 dynamic bone and 6 dynamic bone-marrow scintigraphies were performed in 10 patients. The dynamic scintigraphies were compared with conventional radiography, MR images, and static scintigraphies of bone and bone marrow. Results: No additional information was revealed by the dynamic registration method; on the contrary, 4 of the 8 known lesions were not discerned at dynamic registration. An incidental observation was that the time-activity curves of both radiopharmaceuticals had a specific pattern. (orig.)

  6. Shang Oracle Bones

    Science.gov (United States)

    Pankenier, David W.

    Astronomical observations first appear in China's archaeological record on turtle plastrons and ox scapulae from the reigns of the last few kings of the Shang Dynasty (1250-1046 BCE). A variety of meteorological and astronomical phenomena were divined about and recorded by scribes in formulaic language that is recognizably archaic Chinese. The oracle bone inscriptions record sacrifices to celestial bodies and the proper ritual response to anomalous phenomena like eclipses.

  7. [Primary liposarcoma of bone].

    Science.gov (United States)

    Tatić, V; Cerović, S; Skaro-Milić, A; Jovanović, Z

    2001-01-01

    A case of 75-year-old man with extremely rare primary liposarcoma of the bone was presented. Stains for lipid, Sudan III, Sudan IV, and Oil Red "O", demonstrated the presence of intracellular lipid in the lipoblasts. Similarly, the S-100 immunoreactivity and electron microscopic findings of tumor cells confirmed the diagnosis of liposarcoma. Histochemical stains for PAS, Alcian-blue, mucikarmin, Toluidin-blue and Coloidal Iron were negative. PMID:11419292

  8. Bone tissue engineering

    OpenAIRE

    Black, Cameron R. M.; Goriainov, Vitali; Gibbs, David; Kanczler, Janos; Tare, Rahul S; Richard O. C. Oreffo

    2015-01-01

    Medical advances have led to a welcome increase in life expectancy. However, accompanying longevity introduces new challenges: increases in age-related diseases and associated reductions in quality of life. The loss of skeletal tissue that can accompany trauma, injury, disease or advancing years can result in significant morbidity and significant socio-economic cost and emphasise the need for new, more reliable skeletal regeneration strategies. To address the unmet need for bone augmentation,...

  9. Dispositifs de coordination entre industriel, éleveurs et périmètre irrigué dans un bassin de collecte laitier au Maroc

    OpenAIRE

    Le Gal, Pierre-Yves; Kuper, Marcel; Moulin, Charles-Henri; Puillet, Laurence; Taher Sraïri, Mohamed

    2007-01-01

    Le concept de chaîne d’approvisionnement est appliqué à un ensemble composé d’un bassin de collecte laitière adossé à un grand périmètre irrigué marocain pour en comprendre le fonctionnement. Quatre grands types d’acteurs sont identifiés, à savoir : le gestionnaire de périmètre, l’industriel laitier, les coopératives de collecte et les éleveurs irrigants. Leurs relations sont analysées autour des dispositifs mis en place pour coordonner leurs décisions par rapport aux objectifs d’économie et ...

  10. Revealing the sub-AU asymmetries of the inner dust rim in the disk around the Herbig Ae star R Coronae Austrinae

    Science.gov (United States)

    Kraus, S.; Hofmann, K.-H.; Malbet, F.; Meilland, A.; Natta, A.; Schertl, D.; Stee, P.; Weigelt, G.

    2009-12-01

    Context: Unveiling the structure of the disks around intermediate-mass pre-main-sequence stars (Herbig Ae/Be stars) is essential for our understanding of the star and planet formation process. In particular, models predict that in the innermost AU around the star, the dust disk forms a “puffed-up” inner rim, which should result in a strongly asymmetric brightness distribution for disks seen under intermediate inclination. Aims: Our aim is to constrain the sub-AU geometry of the inner disk around the Herbig Ae star R CrA and search for the predicted asymmetries. Methods: Using the VLTI/AMBER long-baseline interferometer, we obtained 24 near-infrared (H- and K-band) spectro-interferometric observations on R CrA. Observing with three telescopes in a linear array configuration, each data set samples three equally spaced points in the visibility function, providing direct information about the radial intensity profile. In addition, the observations cover a wide position angle range (~97°), also probing the position angle dependence of the source brightness distribution. Results: In the derived visibility function, we detect the signatures of an extended (Gaussian FWHM ~ 25 mas) and a compact component (Gaussian FWHM ~ 5.8 mas), with the compact component contributing about two-thirds of the total flux (both in H- and K-band). The brightness distribution is highly asymmetric, as indicated by the strong closure phases (up to ~40°) and the detected position angle dependence of the visibilities and closure phases. To interpret these asymmetries, we employ various geometric as well as physical models, including a binary model, a skewed ring model, and a puffed-up inner rim model with a vertical or curved rim shape. For the binary and vertical rim model, no acceptable fits could be obtained. On the other hand, the skewed ring model and the curved puffed-up inner rim model allow us to simultaneously reproduce the measured visibilities and closure phases. From these

  11. 车轮轮辋应力超声波测量法的研究%Study on rim stress testing by ultrasound

    Institute of Scientific and Technical Information of China (English)

    周小明; 彭朝勇; 高晓蓉; 郭建强

    2012-01-01

    The feasibility of ultrasonic birefringence method in the rim stress measurement is verified by using the normal measuring equipment and shear-wave straight probe. A new and efficient nondestructive testing method is provided for the wheel rim stress testing, that has great significance to decide the state of trains.%通过利用标准测量设备和超声横波直探头两种测试方法,验证了超声双折射法在轮辋应力测量中的可行性.为车轮轮辋应力检测提供了一种新的高效无损的检测手段,对于列车安全运行状态的判断具有重要意义.

  12. Bone Metabolism on ISS Missions

    Science.gov (United States)

    Smith, S. M.; Heer, M. A.; Shackelford, L. C.; Zwart, S. R.

    2014-01-01

    Spaceflight-induced bone loss is associated with increased bone resorption (1, 2), and either unchanged or decreased rates of bone formation. Resistive exercise had been proposed as a countermeasure, and data from bed rest supported this concept (3). An interim resistive exercise device (iRED) was flown for early ISS crews. Unfortunately, the iRED provided no greater bone protection than on missions where only aerobic and muscular endurance exercises were available (4, 5). In 2008, the Advanced Resistive Exercise Device (ARED), a more robust device with much greater resistance capability, (6, 7) was launched to the ISS. Astronauts who had access to ARED, coupled with adequate energy intake and vitamin D status, returned from ISS missions with bone mineral densities virtually unchanged from preflight (7). Bone biochemical markers showed that while the resistive exercise and adequate energy consumption did not mitigate the increased bone resorption, bone formation was increased (7, 8). The typical drop in circulating parathyroid hormone did not occur in ARED crewmembers. In 2014, an updated look at the densitometry data was published. This study confirmed the initial findings with a much larger set of data. In 42 astronauts (33 male, 9 female), the bone mineral density response to flight was the same for men and women (9), and those with access to the ARED did not have the typical decrease in bone mineral density that was observed in early ISS crewmembers with access to the iRED (Figure 1) (7). Biochemical markers of bone formation and resorption responded similarly in men and women. These data are encouraging, and represent the first in-flight evidence in the history of human space flight that diet and exercise can maintain bone mineral density on long-duration missions. However, the maintenance of bone mineral density through bone remodeling, that is, increases in both resorption and formation, may yield a bone with strength characteristics different from those

  13. Battling Brittle Bones

    Science.gov (United States)

    2002-01-01

    The accuDEXA(R) Bone Mineral Density Assessment System, manufactured by Schick Technologies, Inc., utilizes "camera on a chip" sensor technology invented and developed by NASA's Jet Propulsion Laboratory. Schick's accuDEXA system offers several advantages over traditional osteoporosis tests, which assess bone density loss in the hip and spine, and require specialized personnel to conduct. With accuDEXA, physicians can test the entire body's bone density at a peripheral site, such as the finger, without applying gels or having patients remove garments. Results are achieved in 30 seconds and printed out in less than a minute, compared to the estimated exam time of 15 minutes for hip and spine density analyses. Schick has also applied the CMOS APS technology to a new software product that performs dental radiography using up to 90 percent less radiation exposure than conventional X-rays. Called Computed Dental Radiography(R), the new digital imaging product utilizes an electronic sensor in place of X-ray film to generate sharp and clear images that appear on a computer screen within 3 seconds, and can be enlarged and enhanced to identify problems.

  14. Virtual temporal bone

    Institute of Scientific and Technical Information of China (English)

    QIU Ming-guo; ZHANG Shao-xiang; LIU Zheng-jin; TAN Li-wen; WANG Yu-su; DENG Jun-hui; TANG Ze-sheng

    2002-01-01

    Objective:To provide the virtual model of the temporal bone for improving 3-dimension (3D) visualization of the inner ear. Methods: Plastination technique was used to make equidistant serial thin sections 1.0 mm in thickness. On SGI workstation, a Contours+Marching Cubes algorithm was selected to reconstruct the temporal bone and intratemporal structures in 3D, then to view the middle ear, inner ear, and intratemporal structures which imitate the scenes observed by the traditional endoscopy. Results: The virtual model of the temporal bone was successfully constructed, with all reconstructed structures being represented individually or jointly and being rotated continuously in any plane. Virtual endoscopy improved 3D visualization of the middle ear, inner ear, and intratemporal structures. Conclusion: The reconstructed model can be used for the medical students to rehearse or review the surgeries on this part and for the surgeons to develop a new approach for operation. Virtual otoscopy stands as a promising new visualization technique for elucidating the structure and relation of the middle ear, inner ear, and intratemporal structures.

  15. Bone Metabolism in Adolescents with Anorexia Nervosa

    OpenAIRE

    Misra, Madhusmita; Klibanski, Anne

    2011-01-01

    Adolescents with anorexia nervosa (AN) are at risk for low bone mass at multiple sites, associated with decreased bone turnover. Bone microarchitecture is also affected, with a decrease in bone trabecular volume and trabecular thickness, and an increase in trabecular separation. The adolescent years are typically the time when marked increases occur in bone mass accrual towards the attainment of peak bone mass, an important determinant of bone health and fracture risk in later life. AN often ...

  16. Bone morphogenetic proteins: Periodontal regeneration

    Directory of Open Access Journals (Sweden)

    Subramaniam M Rao

    2013-01-01

    Full Text Available Periodontitis is an infectious inflammatory disease that results in attachment loss and bone loss. Regeneration of the periodontal tissues entails de novo formation of cementum, periodontal ligament, and alveolar bone. Several different approaches are currently being explored to achieve complete, reliable, and reproducible regeneration of periodontal tissues. The therapeutic management of new bone formation is one of the key issues in successful periodontal regeneration. Bone morphogenetic proteins form a unique group of proteins within the transforming growth factor superfamily of genes and have a vital role in the regulation in the bone induction and maintenance. The activity of bone morphogenetic proteins was first identified in the 1960s, but the proteins responsible for bone induction were unknown until the purification and cloning of human bone morphogenetic proteins in the 1980s, because of their osteoinductive potential. Bone morphogenetic proteins have gained a lot of interest as therapeutic agents for treating periodontal defects. A systematic search for data related to the use of bone morphogenetic proteins for the regeneration of periodontal defects was performed to recognize studies on animals and human (PUBMED, MEDLINE, COCHRANE, and Google search. All the studies included showed noticeable regeneration of periodontal tissues with the use of BMP.

  17. USING A PROBLEM SITUATION IN A COMPREHENSIVE TEST (BASED ON THE EXAMPLE OF PREPARATION FOR INTERCULTURAL BUSINESS INTERACTIONS WITHIN THE ASIAN PACIFIC RIM)

    OpenAIRE

    Albina G. Dolgan

    2016-01-01

    Introduction: nowadays Russian people are proactively seeking cooperation with the Asian Pacific Rim. Considering this the author has developed a curricular for institutions of higher learning training students in intercultural business interaction in this region within such disciplines as “Foreign language” and “Professional foreign language”. Materials and Methods: the author puts forward a comprehensive test as a way to define the level of students’ preparedness for business interacti...

  18. High thermal fatigue resistance. PTFE materials with high long-period pressure resistance for narrow-rimmed sealings; Hohe Temperaturwechselbestaendigkeit. Druckstandfeste PTFE-Materialien fuer schmalrandige Dichtungen

    Energy Technology Data Exchange (ETDEWEB)

    Weimer, Norbert [Klinger GmbH, Idstein (Germany)

    2011-03-15

    Narrow-rimmed sealings are common in screw connections. Although they have been in use for many decades, problems still occur due to their exposure to different media, temperatures, and loads. PTFE is a highly adaptable sealing material, with high tightness across the whole cross section, and is easily workable. In a test with temperature cycles of 20 to 120 degC, both the sealing thickness and the rotary momentum exhibited only very slight losses.

  19. Dancing on the Rim of Dreams: A Variety Show Starring Five California Dance Pioneers in Five Acts With Prelude, Sagas, Historical Asides and Finale

    OpenAIRE

    Murphy, Ann

    2011-01-01

    Murphy, Ann: Dancing on the Rim of Dreams: A Variety Show Starring Five California Dance Pioneers in Five Acts with Prelude, Sagas, Historical Asides and FinaleCalifornia entered the national bloodstream in the early days of the Gold Rush and quickly became a mythic place ripe for dreamers, religionists, bigamists, outlaws, failures, utopianists, entrepreneurs, ex-slaves and poets. Tales of the West had been flying East for years, but when word of gold spread in 1849, the stories became a sir...

  20. The Institutional Fragmentation of International Intellectual Property Law in Pacific Rim: Authority and Legitimacy, Regime Interaction and Future Institutional Development in a 'World Society'

    OpenAIRE

    Zuo, AL

    2015-01-01

    Under the context of institutional fragmentation of international IP law in this world society, the international IP law in Pacific Rim is in a flux with various international IP legal actors, including TRIPS, WIPO, CBD, TPP, RECP, FTAAP, etc. With the method of socio-legal analysis emphasizing and basing itself on authority and legitimacy, interaction of IP regimes and future institutional development, this paper investigates the historical evolution of international IP regimes in Pacific Ri...