Comparison of the students’ satisfaction about the performance of academic advisors before and after the advisor project in Shahrekord University of Medical Sciences

Directory of Open Access Journals (Sweden)

MASOUMEH DELARAM

2014-01-01

Full Text Available Introduction: Inappropriate advice interferes with the students’ achievement of educational and professional goals and they may fail to use proper resources for their educational needs. The present study was carried out to compare the students’ satisfaction about the performance of academic advisors before and after the advisor project in Shahrekord University of Medical Sciences. Methods: This longitudinal study was carried out using census report on 244 students in different courses at Shahrekord University of Medical Sciences in two stages at the first semester of 2010-2011 and first semester of 2011-2012. To collect the data, we used a self-designed questionnaire including individual and educational information and 10 multiple-choice questions with Likert scale to assess the students’ satisfaction about the advisors’ performance. Data were analyzed in SPSS 14 using paired t-test, qui-square test. P<0.05 was considered significant. Results: Of the ten items of satisfaction, there was only a significant difference in “accessibility to an advisor before and after the advisor project in students of nursing and midwifery school” (p=0.010, and the difference was not significant in other items in these students. No significant difference was found in ten items of satisfaction in students at other schools before and after the advisor project (p=0.010. Conclusion: It seems that the implementation of advisor project could not provide a satisfactory position for students. Adequate supervision of university officials on proper implementation of the advisor project, supporting faculty advisors and strengthening their position can help to improve the process.

The process of candidates choose graduate programs: an analysis from the advisor perspective

International Nuclear Information System (INIS)

Nascimento, Ridnal Joao do

2016-01-01

This study aims to identify the criteria used by advisors in the decision-making on whether to accept a candidate for mentoring in a postgraduate strictu sensu program and examines possible relationships between this decision and their scientific production and mentees evasion. In order to meet these goals one seeks to identify and analyze the selection criteria of candidates for the master's and doctorate programs at an institution; in this case, the Energy and Nuclear Research Institute - IPEN. More specifically, one seeks to study similarities and differences between those criteria among the advisors; find out whether there is a correlation between the selection criteria and the advisors characteristics (Profile); identify the selection process used by advisors and point out which are the motivations that lead to evasion according to their point of view. To meet these challenges, as the starting point of the research, a conceptual model was designed in order to form the basis for the preparation of the script for the interviews with open-ended questions as to identify the selection criteria used by a small group of advisors with a predefined profile. From that point, based on the responses obtained in interviews, the survey was expanded to all advisors working in the IPEN Postgraduate program by implementing an online survey using Google Docs app for data collection. These data were then analyzed and reorganized according to an operational model of research that would guide the analysis by structural equation modeling (SEM) by means of the SmartPLS software, in order to identify the presence or absence of correlation between the criteria adopted by the advisors and their academic production and the evasion of their mentees, for that one relied on studies in: Bazerman and Moore (2010); Cohen (1988); Hair Jr. et al (2009); Hansmann and Ringle (2004); Martins (1997); Ringle, C.; Silva and Bido (2014); Sousa (2007); Sousa and Yu (2014); Torres (2014); Yu (2011

The role of farm advisors in multifunctional landscapes

DEFF Research Database (Denmark)

Vesterager, Jens Peter; Lindegaard, Klaus

2012-01-01

This study investigates the influence of farm advisors on farmers decisions regarding Multifunctional landscape commons, a concept covering environmental and landscape values that benefit the public but which depend on farmers management practices. The influence of advisors is analysed by combining...

ACADEMIC ADVISORS: VALUES EDUCATED LEADERS

Directory of Open Access Journals (Sweden)

Brizeida Mijares

2008-07-01

Full Text Available The purpose of this article is to study the academic advisors’ profile from the attitudes in the learning process view point, being the center of which the need that as an educator, the advisor has to be a leader educated in values. The research was documental, according to the theoretical contributions of Arana and Batista (2006,  Ortega and Minguez (2001 and Denis (2000, among others. It is concluded that an academic advisor in values allows individual and collective trasnformation and an education without values as its center, it is a hollow and useless education.

Strontium-90 and cesium-137 in total diet (from Jun. 1982 to Dec. 1982)

International Nuclear Information System (INIS)

1982-01-01

Strontium-90 and cesium-137 in total diet (from Jun. to Dec. 1982) were determined. A full one day ordinary diet including three meals, water, tea and other in-between snacks for five persons was collected as a sample of ''total diet'' from 22 sampling locations. The results are shown in a table. (Namekawa, K.)

Strontium-90 and cesium-137 in sea fish (from Jun. 1982 to Dec. 1982)

International Nuclear Information System (INIS)

1982-01-01

Strontium-90 and cesium-137 in sea fish (from Jun. to Dec. 1982) were determined. Fish was collected from 22 sampling locations. Only the edible part was used in case of larger sized fish, and the whole part was used in case of smaller ones. The results are sown in a table. (Namekawa, K.)

Automated Advice: A Portfolio Management Perspective on Robo-Advisors

OpenAIRE

Vukovic, Ana; Bjerknes, Line

2017-01-01

In this paper we investigate the predominant robo-advisor model, uncovering that however novel this solution might be, it also relies religiously on imperative contributions to modern portfolio theory that have been made in the past half a century. Despite conforming by and large to passive investment, we find that the slight variations in the methodologies used by robo-advisors introduce significant variability in risk-adjusted returns across the robo-advisor spectrum. Nonetheless, our perfo...

Perspective of the Science Advisor to the Waste Isolation Pilot Plant

International Nuclear Information System (INIS)

WEART, WENDELL D.

1999-01-01

In 1975 Sandia National Laboratories (SNL) was asked by the predecessor to the Department of Energy to assume responsibility for the scientific programs necessary to assure the safe and satisfactory development of a geologic repository in the salt beds of southeast New Mexico. Sandia has continued in the role of Science Advisor to the Waste Isolation Pilot Plant (WIPP) to the present time. This paper will share the perspectives developed over the past 25 years as the project was brought to fruition with successful certification by the Environmental Protection Agency (EPA) on May 13, 1998 and commencement of operations on April 26, 1999

The fingerprint element analysis on provenance of ancient chinese Jun porcelain

International Nuclear Information System (INIS)

Gao Zhengyao; Chen Songhua; Wang Jie; Huang Zhongxiang; Jia Xiuqin; Han Song

1997-01-01

Forty-three samples of ancient Jun porcelains and so on were chosen. Neutron activation analysis (NAA) was used to measure the 36 trace elements in every sample. Seven elements were chosen as the 'fingerprint elements'. The provenance of the glazes and bodies of ancient Chinese Jun porcelain were investigated by the fingerprint element analysis method. The result shows that although the ancient Chinese Jun porcelain samples have been leapt over six hundred years, and glaze colors are utterly different and are from many different kilns, there are long term, stable and same mainly raw material source. The near provenance relation between ancient Jun porcelain and ancient Ru porcelain is preliminarily analyzed. A few modern Jun porcelains approximate from ancient Jun porcelains, the majority become estranged from ancient Jun porcelain

[Expression of c-jun protein after experimental rat brain concussion].

Science.gov (United States)

Wang, Feng; Li, Yong-hong

2010-02-01

To observe e-jun protein expression after rat brain concussion and explore the forensic pathologic markers following brain concussion. Fifty-five rats were randomly divided into brain concussion group and control group. The expression of c-jun protein was observed by immunohistochemistry. There were weak positive expression of c-jun protein in control group. In brain concussion group, however, some neutrons showed positive expression of c-jun protein at 15 min after brain concussion, and reach to the peak at 3 h after brain concussion. The research results suggest that detection of c-jun protein could be a marker to determine brain concussion and estimate injury time after brain concussion.

Gene activated by growth factors is related to the oncogene v-jun

International Nuclear Information System (INIS)

Ryder, K.; Lau, L.F.; Nathans, D.

1988-01-01

The authors have recently identified by cDNA cloning a set of genes that are rapidly activated in cultured mouse cells by protein growth factors. Here they report that the nucleotide sequence of a cDNA (clone 465) derived from one of these immediate early genes (hereafter called jun-B) encodes a protein homologous to that encoded by the avian sarcoma virus 17 oncogene v-jun. Homology between the jun-B and v-jun proteins is in two regions: one near the N terminus and the other at the C terminus. The latter sequence was shown to have regions of sequence similarity to the DNA-binding domain of the yeast transcriptional regulatory protein GCN4 and to the oncogenic protein fos. Southern blots of human, mouse, and chicken DNA demonstrate that jun-B and c-jun are different genes and that there may be other vertebrate genes related to jun-B and c-jun. These findings suggest that there is a jun family of genes encoding related transcriptional regulatory proteins. The jun-B protein, and perhaps other members of the jun family, may play a role in regulating the genomic response to growth factors

Senior Enlisted Advisor to the CNGB - The National Guard

Science.gov (United States)

ARNG Readiness Home : Leadership : SEA Senior Enlisted Advisor to the CNGB Command Sergeant Major Christopher Kepner Command Sergeant Major Christopher Kepner currently serves as the Senior Enlisted Advisor include the United States Army Sergeants Major Academy, Senior Enlisted Joint Professional Military

17 CFR 4.14 - Exemption from registration as a commodity trading advisor.

Science.gov (United States)

2010-04-01

... a commodity trading advisor. 4.14 Section 4.14 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION COMMODITY POOL OPERATORS AND COMMODITY TRADING ADVISORS General Provisions, Definitions and Exemptions § 4.14 Exemption from registration as a commodity trading advisor. This section is...

Marketing advisors and their role for junior gas producers

Energy Technology Data Exchange (ETDEWEB)

Maffitt, D.W. [Phoenix Gas Marketing Consultants Inc., Calgary, AB (Canada)

1997-05-01

The role of marketing advisors in the new deregulated natural gas industry was discussed. These producer-oriented marketing consultants are specialists in providing affordable marketing services to junior gas producers on an `as-needed` basis. The most important service provided by marketing advisors is helping the client identify management problems, analyze such problems and recommend solutions. Accordingly, the marketing advisor should be independent and objective, with no conflict of interests. He/she should be prepared to invest a lot of time and effort in providing the junior producer with a customized diagnosis of its marketing problems. 5 refs., 3 figs.

Marketing advisors and their role for junior gas producers

International Nuclear Information System (INIS)

Maffitt, D.W.

1997-01-01

The role of marketing advisors in the new deregulated natural gas industry was discussed. These producer-oriented marketing consultants are specialists in providing affordable marketing services to junior gas producers on an 'as-needed' basis. The most important service provided by marketing advisors is helping the client identify management problems, analyze such problems and recommend solutions. Accordingly, the marketing advisor should be independent and objective, with no conflict of interests. He/she should be prepared to invest a lot of time and effort in providing the junior producer with a customized diagnosis of its marketing problems. 5 refs., 3 figs

Data Transfer Advisor with Transport Profiling Optimization

Energy Technology Data Exchange (ETDEWEB)

Rao, Nageswara S. [ORNL; Liu, Qiang [ORNL; Yun, Daqing [Harrisburg University; Wu, Chase Qishi [New Jersey Institute of Technology; Kettimuthu, R. [Argonne National Laboratory (ANL); Jung, Eun-sung [Argonne National Laboratory (ANL)

2017-11-01

The network infrastructures have been rapidly upgraded in many high-performance networks (HPNs). However, such infrastructure investment has not led to corresponding performance improvement in big data transfer, especially at the application layer, largely due to the complexity of optimizing transport control on end hosts. We design and implement ProbData, a PRofiling Optimization Based DAta Transfer Advisor, to help users determine the most effective data transfer method with the most appropriate control parameter values to achieve the best data transfer performance. ProbData employs a profiling optimization based approach to exploit the optimal operational zone of various data transfer methods in support of big data transfer in extreme scale scientific applications. We present a theoretical framework of the optimized profiling approach employed in ProbData as wellas its detailed design and implementation. The advising procedure and performance benefits of ProbData are illustrated and evaluated by proof-of-concept experiments in real-life networks.

West Europe Report Tables of Contents JPRS-WER-86-064, 2 July 1986 JPRS-WER-86-124, 31 Dec 1986.

Science.gov (United States)

1987-03-30

Villena; EL PAIS, 21 May 86) 97 MERCADO Reviews 1985 INI Results Under Croissier Management ( MERCADO , 23 May 86) 98 Economic Growth for...13 Jun 86) . 18 a - 3T GREECE ITALY PASOK’s Municipal Elections Strategy (EMBISTEVTIKO GRAMMA, 4 Jun 86) 21 Trends in Recent...Parliamentary, Municipal Elections Compared (EMBISTEVTIKO GRAMMA, 4 Jun 86) 22 PSI’s Martinelli Supports Justice Referendum for Reform (Claudio Martinelli

ADVISOR Users Conference Proceedings 2000 - Final Electronic version

Energy Technology Data Exchange (ETDEWEB)

NREL

2000-09-26

This is a compilation of papers presented at the ADVISOR (ADvanced Vehicle SimulatOR) Users Conference held in Costa Mesa, California, August 24-25, 2000. Major topics of the conference included modeling and simulation; partnering with the auto industry; co-simulation: partnering with the software industry in optimization and thermal modeling and geometric and mechanical modeling; forward-looking simulations coupled with ADVISOR; new concepts from universities; validation, vehicle development and applications.

78 FR 11702 - AdvisorShares Investments, LLC and AdvisorShares Trust; Notice of Application

Science.gov (United States)

2013-02-19

..., American Wealth Management, Trim Tabs Asset Management, LLC, Rockledge Advisors, LLC, Your Source Financial... of Investment Management, Office of Investment Company Regulation). SUPPLEMENTARY INFORMATION: The... organized as a Delaware statutory trust and is registered under the Act as an open-end management investment...

The challenges of science journalism: The perspectives of scientists, science communication advisors and journalists from New Zealand.

Science.gov (United States)

Ashwell, Douglas James

2016-04-01

The news media play an important role in informing the public about scientific and technological developments. Some argue that restructuring and downsizing result in journalists coming under increased pressure to produce copy, leading them to use more public relations material to meet their deadlines. This article explores science journalism in the highly commercialised media market of New Zealand. Using semi-structured interviews with scientists, science communication advisors and journalists, the study finds communication advisors and scientists believe most media outlets, excluding public service media, report science poorly. Furthermore, restructuring and staff cuts have placed the journalists interviewed under increasing pressure. While smaller newspapers appear to be printing press releases verbatim, metropolitan newspaper journalists still exercise control over their use of such material. The results suggest these journalists will continue to resist increasing their use of public relations material for some time to come. © The Author(s) 2014.

Perceptions of Effectiveness and Job Satisfaction of Pre-Law Advisors

Science.gov (United States)

Knotts, H. Gibbs; Wofford, Claire B.

2017-01-01

Despite playing an important role, preprofessional advising has received little research attention. For this study, 313 U.S. preprofessional advisors were surveyed in 2015. Drawing on work adjustment and social cognitive career theories, we analyzed the job satisfaction and perceived effectiveness of pre-law advisors. The major findings reveal…

DISTINCT FUNCTIONS OF JNK AND C-JUN IN OXIDANT-INDUCED HEPATOCYTE DEATH

Science.gov (United States)

Amir, Muhammad; Liu, Kun; Zhao, Enpeng; Czaja, Mark J.

2013-01-01

Overactivation of c-Jun N-terminal kinase (JNK)/c-Jun signaling is a central mechanism of hepatocyte injury and death including that from oxidative stress. However, the functions of JNK and c-Jun are still unclear, and this pathway also inhibits hepatocyte death. Previous studies of menadione-induced oxidant stress demonstrated that toxicity resulted from sustained JNK/c-Jun activation as death was blocked by the c-Jun dominant negative TAM67. To further delineate the function of JNK/c-Jun signaling in hepatocyte injury from oxidant stress, the effects of direct JNK inhibition on menadione-induced death were examined. In contrast to the inhibitory effect of TAM67, pharmacological JNK inhibition by SP600125 sensitized the rat hepatocyte cell line RALA255-10G to death from menadione. SP600125 similarly sensitized mouse primary hepatocytes to menadione toxicity. Death from SP600125/menadione was c-Jun dependent as it was blocked by TAM67, but independent of c-Jun phosphorylation. Death occurred by apoptosis and necrosis and activation of the mitochondrial death pathway. Short hairpin RNA knockdowns of total JNK or JNK2 sensitized to death from menadione, whereas a jnk1 knockdown was protective. Jnk2 null mouse primary hepatocytes were also sensitized to menadione death. JNK inhibition magnified decreases in cellular ATP content and β-oxidation induced by menadione. This effect mediated cell death as chemical inhibition of β-oxidation also sensitized cells to death from menadione, and supplementation with the β-oxidation substrate oleate blocked death. Components of the JNK/c-Jun signaling pathway have opposing functions in hepatocyte oxidant stress with JNK2 mediating resistance to cell death and c-Jun promoting death. PMID:22644775

Immunohistological Analysis of the Jun Family and the Signal Transducers and Activators of Transcription in Thymus

Directory of Open Access Journals (Sweden)

Alexandra Papoudou-Bai

2015-01-01

Full Text Available The Jun family and the signal transducers and activators of transcription (STAT are involved in proliferation and apoptosis. Moreover, c-Jun and STAT3 cooperate to regulate apoptosis. Therefore, we used double immunostaining to investigate the immunotopographical distribution of phospho-c-Jun (p-c-Jun, JunB, JunD, p-STAT3, p-STAT5, and p-STAT6 in human thymus. JunD was frequently expressed by thymocytes with higher expression in medullary compared to cortical thymocytes. p-c-Jun was frequently expressed by cortical and medullary thymic epithelial cells (TEC and Hassall bodies (HB. p-STAT3 was frequently expressed by TEC with higher expression in cortical compared to medullary TEC and HB. p-c-Jun, JunB, p-STAT3, p-STAT5, and p-STAT6 were rarely expressed by thymocytes. JunB and JunD were expressed by rare cortical TEC with higher expression in medullary TEC. p-STAT5 and p-STAT6 were expressed by rare cortical and medullary TEC. Double immunostaining revealed p-c-Jun and JunD expression in rare CD11c positive dendritic cells. Our findings suggest a notable implication of JunD in the physiology of thymocytes and p-c-Jun and p-STAT3 in the physiology of TEC. The diversity of the immunotopographical distribution and the expression levels of p-c-Jun, JunB, JunD, p-STAT3, p-STAT5, and p-STAT6 indicates that they are differentially involved in the differentiation of TEC, thymocytes, and dendritic cells.

Neutron activation analysis of some ancient and modern Chinese Jun Porcelain samples

International Nuclear Information System (INIS)

Gao Zhengyao; Wang Jie; Chen Songhua; Huang Zhongxiang; Han Song; Jia Xiuqin

1997-01-01

Up to 43 glaze and body samples of ancient and modern Chinese Jun Porcelain and other porcelain are chosen and contents of 36 elements for each sample are determined by NAA. The NAA data are then analysed by the fuzzy cluster method. The result shows that although the ancient Jun Porcelain samples span leaped 600 years and are from different kilns and their glaze colors are utterly different, they have a long-term, stable and mainly the same supply of raw material. The relation between ancient Jun Porcelain and ancient Ru Porcelain is also preliminarily analysed. It is found that only few modern Jun Porcelain samples are similar to ancient Jun Porcelain but the majority of them are different from ancient ones

An Iraq C-130 Aviation Advisor Mission and Lessons for the Future

National Research Council Canada - National Science Library

Bauer, Michael J

2007-01-01

.... A review of lessons learned from the initial Iraq C-130 advisor mission provided insights into challenges stemming from differences in United States advisors and Iraqi airmen in language, culture...

Differential effects of v-Jun and c-Jun proteins on v-myb-transformed monoblasts

Czech Academy of Sciences Publication Activity Database

Ševčíková, S.; Souček, Karel; Kubala, Lukáš; Bryja, Vítězslav; Šmarda, J.

2002-01-01

Roč. 59, č. 10 (2002), s. 1690-1705 ISSN 1420-682X R&D Projects: GA ČR GA301/01/0040 Institutional research plan: CEZ:AV0Z5004920 Keywords : v-myb * Jun * differentiation Subject RIV: BO - Biophysics Impact factor: 5.259, year: 2002

Fos and jun proteins are specifically expressed during differentiation of human keratinocytes.

Science.gov (United States)

Mehic, Denis; Bakiri, Latifa; Ghannadan, Minoo; Wagner, Erwin F; Tschachler, Erwin

2005-01-01

Activator protein 1 (AP-1) proteins play key roles in the regulation of cell proliferation and differentiation. In this study we investigated the expression of Fos and Jun proteins in different models of terminal differentiation of human keratinocytes and in skin from psoriasis patients. All Jun and Fos proteins, with the exception of FosB, were efficiently expressed in keratinocytes in monolayer cultures. In contrast, in normal epidermis as well as in organotypic epidermal cultures, the expression pattern of AP-1 proteins was dependent on the differentiation stage. Fos proteins were readily detected in nuclei of keratinocytes of basal and suprabasal layers. JunB and JunD were expressed in all layers of normal epidermis. Interestingly, expression of c-Jun started suprabasally, then disappeared and became detectable again in distinct cells of the outermost granular layer directly at the transition zone to the stratum corneum. In psoriatic epidermis, c-Jun expression was prominent in both hyperproliferating basal and suprabasal keratinocytes, whereas c-Fos expression was unchanged. These data indicate that AP-1 proteins are expressed in a highly specific manner during terminal differentiation of keratinocytes and that the enhanced expression of c-Jun in basal and suprabasal keratinocytes might contribute to the pathogenesis of psoriasis.

The Advisor and Instructor as a Dynamic Duo: Academic Motivation and Basic Psychological Needs

Science.gov (United States)

Burt, Tracie D.; Young-Jones, Adena D.; Yadon, Carly A.; Carr, Michael T.

2013-01-01

Students learn in and out of a formal classroom, and instructors and academic advisors play key roles in academic motivation and learning. Therefore, through the lens of self-determination theory, we examined the ways perceived support from instructors and advisors relates to satisfaction of college students' basic psychological needs. Advisor and…

Overexpression of c-Jun contributes to sorafenib resistance in human hepatoma cell lines.

Directory of Open Access Journals (Sweden)

Yuki Haga

Full Text Available Despite recent advances in treatment strategies, it is still difficult to cure patients with hepatocellular carcinoma (HCC. Sorafenib is the only approved multiple kinase inhibitor for systemic chemotherapy in patients with advanced HCC. The majority of advanced HCC patients are resistant to sorafenib. The mechanisms of sorafenib resistance are still unknown.The expression of molecules involved in the mitogen-activated protein kinase (MAPK signaling pathway in human hepatoma cell lines was examined in the presence or absence of sorafenib. Apoptosis of human hepatoma cells treated with sorafenib was investigated, and the expression of Jun proto-oncogene (c-Jun was measured.The expression and phosphorylation of c-Jun were enhanced in human hepatoma cell lines after treatment with sorafenib. Inhibiting c-Jun enhanced sorafenib-induced apoptosis. The overexpression of c-Jun impaired sorafenib-induced apoptosis. The expression of osteopontin, one of the established AP-1 target genes, was enhanced after treatment with sorafenib in human hepatoma cell lines.The protein c-Jun plays a role in sorafenib resistance in human hepatoma cell lines. The modulation and phosphorylation of c-Jun could be a new therapeutic option for enhancing responsiveness to sorafenib. Modulating c-Jun may be useful for certain HCC patients with sorafenib resistance.

Student goal orientation in learning inquiry skills with modifiable software advisors

Science.gov (United States)

Shimoda, Todd Adrian

A computer support environment (SCI-WISE) for learning and doing inquiry was designed. The system incorporates software advisors that give task completion advice (eg., forming hypotheses), general purpose advice (e.g., brainstorming), or system modification advice. Advisors' knowledge includes concepts, strategies, examples, referrals to other advisors, and criteria for evaluating good products and skills. Students using SCI-WISE can select the advisors' advice type (specific, general, or hints), and when advisors give advice (anytime, alert, or ask). Students can also modify the advisors' knowledge. The system is designed partly on a theoretical framework that assumes giving students higher levels of agency will facilitate higher-level goal orientation (such as knowledge-building) and produce higher levels of competence. In two studies of sixth graders, science students took a pretest of an open-ended inquiry question and a questionnaire that measured their goal orientations. The students worked in pairs on an inquiry project about memory, using one of two versions of SCI-WISE, one modifiable and one not modifiable. After finishing the project, the students took a posttest similar to the pretest, and evaluated the system. The main hypotheses predicted that knowledge-oriented students using the modifiable version would rate the system higher, use it more effectively, and do better on the inquiry posttest than task-oriented students. The results supported many of the hypotheses generated from the theoretical framework. Knowledge-oriented students tended to rate SCI-WISE higher, use more general purpose and system development advisors, and select more general advice and hints than task-oriented students. On the posttest inquiry test, students with higher goal orientations scored higher on average, particularly when paired with another knowledge oriented student. The studies also showed that goal orientation was not correlated with grade point average. Finally, the

Knowledge representation and knowledge base design for operator advisor system

International Nuclear Information System (INIS)

Hangos, K.M.; Sziano, T.; Tapolcai, L.

1990-01-01

The problems of knowledge representation, knowledge base handling and design has been described for an Operator Advisor System in the Paks Nuclear Power Plant. The Operator Advisor System is to be implemented as a part of the 5th and 6th unit. The knowledge of the Operator Advisor system is described by a few elementary knowledge items (diagnostic event functions, fault graph, action trees), weighted directed graphs have been found as their common structure. List-type and relational representation of these graphs have been used for the on-line and off-line part of the knowledge base respectively. A uniform data base design and handling has been proposed which consists of a design system, a knowledge base editor and a knowledge base compiler

40 CFR 98.38 - Definitions.

Science.gov (United States)

2010-07-01

... Still Gas 0.143 66.72 Kerosene 0.135 75.20 Liquefied petroleum gases (LPG) 0.092 62.98 Propane 0.091 61... GREENHOUSE GAS REPORTING General Stationary Fuel Combustion Sources § 98.38 Definitions. All terms used in... 93.65 Mixed (Industrial sector) 22.35 93.91 Mixed (Electric Power sector) 19.73 94.38 Natural gas mm...

Critical role of c-Jun overexpression in liver metastasis of human breast cancer xenograft model

International Nuclear Information System (INIS)

Zhang, Yan; Hu, Meiru; Shen, Beifen; Guo, Ning; Pu, Xiaoyun; Shi, Ming; Chen, Liyong; Song, Yuhua; Qian, Lu; Yuan, Guogang; Zhang, Hao; Yu, Ming

2007-01-01

c-Jun/AP-1 has been linked to invasive properties of aggressive breast cancer. Recently, it has been reported that overexpression of c-Jun in breast cancer cell line MCF-7 resulted in increased AP-1 activity, motility and invasiveness of the cells in vitro and tumor formation in nude mice. However, the role of c-Jun in metastasis of human breast cancer in vivo is currently unknown. To further investigate the direct involvement of c-Jun in tumorigenesis and metastasis, in the present study, the effects of c-Jun overexpression were studied in both in vitro and in nude mice. Ectopic overexpression of c-Jun promoted the growth of MCF-7 cells and resulted in a significant increase in the percentage of cells in S phase and increased motility and invasiveness. Introduction of c-Jun gene alone into weakly invasive MCF-7 cells resulted in the transfected cells capable of metastasizing to the nude mouse liver following tail vein injection. The present study confirms that overexpression of c-Jun contributes to a more invasive phenotype in MCF-7 cells. It indicates an interesting relationship between c-Jun expression and increased property of adhesion, migration and in vivo liver metastasis of MCF-7/c-Jun cells. The results provide further evidence that c-Jun is involved in the metastasis of breast cancer. The finding also opens an opportunity for development of anti-c-Jun strategies in breast cancer therapy

Study on provenance of Ru porcelain in yanhedian kiln and official jun porcelain by EDXRF

International Nuclear Information System (INIS)

Li Guoxia; Guo Min; Zhao Weijuan; Sun Hongwei; Gao Zhengyao; Xie Jianzhong; Wen Chang; Wang Chuan; Li Rongwu; Guo Peiyu; Yang Dawei

2010-01-01

To understand the provenance relationship of Ru porcelain in Yanhedian kiln and official Jun porcelain , with energy dispersive x-ray fluorescence spectrometer (EDXRF) measured 56 Ru porcelain in Yanhedian kiln and official Jun porcelain samples of chemical composition of the main volume, analysis results show: Yanhedian kiln Ru porcelain bodies Al 2 O 3 average content Outpaces official Jun porcelain bodies, SiO 2 , K 2 O average below official Jun porcelain bodies; Yanhedian kiln Ru porcelain glazes Al 2 O 3 average content Outpaces official Jun porcelain glaze, SiO 2 , CaO average significantly lower than Jun glaze, two primary body and glaze on porcelain to chemical composition of the averages vary. A display of the peacekeeping two-dimensional scatter analysis supplies of official Jun porcelain bodies focused, Yanhedia kiln Ru porcelain bodies birth supplies comparatively, Jun and Yanhedian kiln Ru porcelain bodies material habitats near but not identical. The official Jun porcelain glazes origin focused, glaze formula changes less, and Yanhedia kiln Ru porcelain glazes origin and formula are scattered. Therefore, Yanhedian kiln Ru porcelain samples and the Official Jun porcelain samples can be commendably differentiated by EDXRF testing and chemical composition scatter analysis. (authors)

Inhibition of c-Jun N-terminal kinase sensitizes tumor cells to flavonoid-induced apoptosis through down-regulation of JunD

International Nuclear Information System (INIS)

Kook, Sung-Ho; Son, Young-Ok; Jang, Yong-Suk; Lee, Kyung-Yeol; Lee, Seung-Ah; Kim, Beom-Soo; Lee, Hyun-Jeong; Lee, Jeong-Chae

2008-01-01

Reduction of susceptibility to apoptosis signals is a crucial step in carcinogenesis. Therefore, sensitization of tumor cells to apoptosis is a promising therapeutic strategy. c-Jun NH 2 -terminal kinase (JNK) has been implicated in stress-induced apoptosis. However, many studies also emphasize the role of JNK on cell survival, although its mechanisms are not completely understood. Previously, we found that inhibition of JNK activity promotes flavonoid-mediated apoptosis of human osteosarcoma cells. We thus determined whether inhibition of JNK sensitizes tumor cells to a bioflavonoid-induced apoptosis, and whether this effect of JNK is a general effect. As the results, quercetin and genistein as well as a flavonoid fraction induced apoptosis of tumor cells, which was further accelerated by specific JNK inhibitor, SP600125 or by small interfering RNA specific to JNK1/2. This effect was specific to types of cells because it was further apparent in tumorigenic cell lines. Inhibition of JNK by SP600125 also reduced flavonoid-stimulated nuclear induction of JunD which was known to have protective role in apoptosis, whereas JNK inhibition alone had little effect on apoptosis. The flavonoid-induced apoptosis of tumor cells was significantly enhanced by transfecting them with antisense JunD oligonucleotides. These results suggest that inhibition of JNK facilitates flavonoid-induced apoptosis through down-regulation of JunD, which is further sensitive to tumor cells. Therefore, combination with a specific JNK inhibitor further enhances the anti-cancer and chemopreventive potential of bio-flavonoids

Tissue-specific deletion of c-Jun in the pancreas has limited effects on pancreas formation

International Nuclear Information System (INIS)

Yamamoto, Kaoru; Miyatsuka, Takeshi; Tanaka, Ayako; Toyoda, Shuichi; Kato, Ken; Shiraiwa, Toshihiko; Fujitani, Yoshio; Yamasaki, Yoshimitsu; Hori, Masatsugu; Matsuhisa, Munehide; Matsuoka, Taka-aki; Kaneto, Hideaki

2007-01-01

It is well known that activating protein-1 (AP-1) is involved in a variety of cellular functions such as proliferation, differentiation, apoptosis, and oncogenesis. AP-1 is a dimer complex consisting of different subunits, and c-Jun is known to be one of its major components. In addition, it has been shown that mice lacking c-Jun are embryonic lethal and that c-Jun is essential for liver and heart development. However, the role of c-Jun in the pancreas is not well known. The aim of this study was to examine the possible role of c-Jun in the pancreas. First, c-Jun was strongly expressed in pancreatic duct-like structures at an embryonic stage, while a lower level of expression was observed in some part of the adult pancreas, implying that c-Jun might play a role during pancreas development. Second, to address this point, we generated pancreas-specific c-Jun knock-out mice (Ptf1a-Cre; c-Jun flox/flox mice) by crossing Ptf1a-Cre knock-in mice with c-Jun floxed mice. Ptf1a is a pancreatic transcription factor and its expression is confined to pancreatic stem/progenitor cells, which give rise to all three types of pancreatic tissue: endocrine, exocrine, and duct. Contrary to our expectation, however, there was no morphological difference in the pancreas between Ptf1a-Cre; c-Jun flox/flox and control mice. In addition, there was no difference in body weight, pancreas weight, and the expression of various pancreas-related factors (insulin, glucagon, cytokeratin, and amylase) between the two groups. Furthermore, there was no difference in glucose tolerance between Ptf1a-Cre; c-Jun flox/flox and control mice. Taken together, although we cannot exclude the possibility that c-Jun ablation is compensated by some unknown factors, c-Jun appears to be dispensable for pancreas development at least after ptf1a gene promoter is activated

Explaining Doctoral Students' Relational Maintenance with Their Advisor: A Psychosocial Development Perspective

Science.gov (United States)

Goldman, Zachary W.; Goodboy, Alan K.

2017-01-01

This study explored how psychosocial development affects doctoral students' relationship and communication with their advisor. Chickering and Reisser's vectors of psychosocial development were examined in the doctoral context to understand how students preserve communicatively satisfying relationships with their advisor through the use of…

Solar Advisor Model User Guide for Version 2.0

Energy Technology Data Exchange (ETDEWEB)

Gilman, P.; Blair, N.; Mehos, M.; Christensen, C.; Janzou, S.; Cameron, C.

2008-08-01

The Solar Advisor Model (SAM) provides a consistent framework for analyzing and comparing power system costs and performance across the range of solar technologies and markets, from photovoltaic systems for residential and commercial markets to concentrating solar power and large photovoltaic systems for utility markets. This manual describes Version 2.0 of the software, which can model photovoltaic and concentrating solar power technologies for electric applications for several markets. The current version of the Solar Advisor Model does not model solar heating and lighting technologies.

EDXRF analysis of Yanhedian Ru kiln and Jun official kiln porcelain

International Nuclear Information System (INIS)

Wen Chang; Zhao Huixian; Li Guoxia; Gao Zhengyao; Zhao Weijuan; Sun Hongwei; Guo Min; Xie Jianzhong; Li Rongwu; Guo Peiyu

2009-01-01

The chemical components of the body and glaze samples of some Ru porcelains from Yanhedian kiln and Jun official porcelains from Juntai kiln are determined by the technology of Energy Dispersive X-ray Fluorescence(EDXRF) in this work. The difference of the two kiln's glaze and body are analyzed by factor analysis method of Multi-dimensional statistical analysis. The results indicate that Yanhedian Ru porcelains can be well distinguished from Jun official porcelains from Juntai kiln. This evidence once again proves that Jun ceramics and Ru ceramics can be distinguished obviously. (authors)

The American Military Advisor: Dealing with Senior Foreign Officials in the Islamic World

National Research Council Canada - National Science Library

Metrinko, Michael J

2008-01-01

"The American Military Advisor: Dealing with Senior Foreign Officials in the Islamic World" is a comprehensive guide for American military officers assigned as advisors to regional officials in places very different from the United States...

Senior Media Relations Advisor | IDRC - International Development ...

International Development Research Centre (IDRC) Digital Library (Canada)

In addition, the Advisor contributes to the Centre's corporate strategic and ... of media strategies, opportunities, approaches, and initiatives to enhance awareness, ... The job demands strategic thinking and planning skills as well as diplomacy, ...

Compensation Services Advisor | IDRC - International Development ...

International Development Research Centre (IDRC) Digital Library (Canada)

Job Summary The Compensation Services Advisor is accountable for the effective ... Coordinates the annual Performance Review and Assessment System ... by IDRC and the broader financial and social implications of working in Canada. ... in areas such as mortgages, credit and so on to individuals not accustomed to ...

ZZ RRDF-98, Cross-sections and covariance matrices for 22 neutron induced dosimetry reactions

International Nuclear Information System (INIS)

Zolotarev, K.I.; Ignatyuk, A.V.; Mahokhin, V.N.; Pashchenko, A.B.

2005-01-01

1 - Description of program or function: Format: ENDF-6 format; Number of groups: Continuous energy; Dosimetry reactions: 6-C-12(n,2n), 8-O-16(n,2n), 9-F-19(n,2n), 12-Mg-24(n,p), 22-Ti-46(n,2n), 22-Ti-46(n,p), 22-Ti-47(n,x), 22-Ti-48(n,p), 22-Ti-48(n,x), 22-Ti-49(n,x), 23-V-51(n,alpha), 26-Fe-54(n,2n), 26-Fe-54(n,alpha), 26-Fe-56(n,p), 27-Co-59(n,alpha), 29-Cu-63(n,alpha), 33-As-75(n,2n), 41-Nb-93(n,2n), 41-Nb-93(n,n'), 45-Rh-103(n,n'), 49-In-115(n,n'), 59-Pr-141(n,2n); Origin: Russian Federation; Weighting spectrum: None. RRDF-98 contains original evaluations of cross section data performed at the Institute of Physics and Power Engineering, Obninsk, for 22 neutron induced dosimetry reactions. The dataset also contains the corresponding covariance matrices. 2 - Methods: The evaluation of excitation functions was performed on the basis of statistical analysis of corrected experimental data in the framework of generalized least squares method and taking into account the results of optical-statistical STAPRE and GNASH calculations. The experimental cross section data including the most recent results were critically reviewed and processed in this study. If necessary, the data were normalized in order to make adjustments in relevant cross sections and decay schemes. The covariance matrices were prepared and the evaluated cross section data are presented in ENDF-6 format (Files 3, 33). For estimation of correlations between experimental data the total uncertainties of measured cross sections have been separated into statistical and systematic parts and correlation coefficients between components of systematic parts were assigned according to information given in the original publications and EXFOR library. Then the correlation matrix of cross sections measured within one experiment was calculated and approximated by matrix with a constant (average) correlation coefficient. The overall correlation matrix was composed of such sub-matrices in the assumption that the cross

Inhibition of transcriptional activity of c-JUN by SIRT1

International Nuclear Information System (INIS)

Gao Zhanguo; Ye Jianping

2008-01-01

c-JUN is a major component of heterodimer transcription factor AP-1 (Activator Protein-1) that activates gene transcription in cell proliferation, inflammation and stress responses. SIRT1 (Sirtuin 1) is a histone deacetylase that controls gene transcription through modification of chromatin structure. However, it is not clear if SIRT1 regulates c-JUN activity in the control of gene transcription. Here, we show that SIRT1 associated with c-JUN in co-immunoprecipitation of whole cell lysate, and inhibited the transcriptional activity of c-JUN in the mammalian two hybridization system. SIRT1 was found in the AP-1 response element in the matrix metalloproteinase-9 (MMP9) promoter DNA leading to inhibition of histone 3 acetylation as shown in a ChIP assay. The SIRT1 signal was reduced by the AP-1 activator PMA, and induced by the SIRT1 activator Resveratrol in the promoter DNA. SIRT1-mediaetd inhibition of AP-1 was demonstrated in the MMP9 gene expression at the gene promoter, mRNA and protein levels. In mouse embryonic fibroblast (MEF) with SIRT1 deficiency (SIRT1 -/- ), mRNA and protein of MMP9 were increased in the basal condition, and the inhibitory activity of Resveratrol was significantly attenuated. Glucose-induced MMP9 expression was also inhibited by SIRT1 in response to Resveratrol. These data consistently suggest that SIRT1 directly inhibits the transcriptional activity of AP-1 by targeting c-JUN

Originating relation studies on ancient porcelains of chines Ru and Jun by NAA

International Nuclear Information System (INIS)

Zhao Weijuan; Xie Jianzhong; Gao Zhengyao; Li Guoxia; Li Rongwu; Zhang Bin

2002-01-01

50 samples of glazes and bodies of the ancient Chinese Ru porcelain, Jun porcelain and imitative ancient ceramics were analyzed by neutron activation analysis (NAA). The contents of 36 elements in each sample were measured. The NAA data were statistically treated by fuzzy cluster method and the trend cluster diagram was obtained. Their classes and raw material sources were determined. The results show that although these samples spanned hundreds of years, came from different kilns and had different glazes colors, the bodies of the ancient Chinese Ru porcelain and Jun porcelain belong to the same kind, the glazes of the ancient Chinese Ru porcelain is similar to the glazes of the ancient Chinese Jun porcelain. The originating places of the body raw material were concentrated, and that of the glaze raw materials were scattered, the source of the glaze raw material covered that the body raw material. The ancient Chinese Ru porcelain and Jun porcelain have basically the same raw material sources and the sources of raw material are stable in long time. It is found that most modern Jun porcelain samples are similar to the ancient Chinese Jun porcelain. Two modern Ru porcelain samples are similar to the ancient Chinese Ru porcelain, but another one drifts apart from the ancient Chinese Ru porcelain. Jingdezhen porcelain has no relation to Ru porcelain and Jun porcelain

Industrial-Organizational and Human Factors Graduate Program Admission: Information for Undergraduate Advisors

Science.gov (United States)

Shoenfelt, Elizabeth L.; Stone, Nancy J.; Kottke, Janet L.

2015-01-01

Many psychology departments do not have industrial-organizational (IO) or human factors (HF) faculty members. As such, potential IO and HF graduate students may miss career opportunities because faculty advisors are unfamiliar with the disciplines and their graduate programs. To assist advisors, this article highlights the content of IO and HF…

The Home, the Family and the Energy Advisor

DEFF Research Database (Denmark)

Tjørring, Lise

within. The empirical focus is on the households' potential to perform energy renovations of their homes and adopt flexible electricity use. Four papers investigate what characterises the social and gendered engagements among the home, the family and the energy advisor and the implications...... events, social relations, historical conditions and social status. These findings call for new methods to increase the number of energy renovations and the likelihood of adopting flexible electricity use. We must focus on the home not only as a technical issue that can be improved but also as a dwelling...... space that contains gendered practices, cultural norms and social engagements among the home, the family and the energy advisor....

The influence of TripAdvisor portal on hotel bussines in Serbia

Directory of Open Access Journals (Sweden)

Čačić Krunoslav

2013-01-01

Full Text Available Numerous researches have shown the existence of influence of specialized Web 2.0 portals on hotel business. One of most famous portals of that kind is TripAdvisor. The goal of this work is to determine the degree and mode of representation of hotels in Serbia on TripAdvisor portal. The results of the conducted research show that in past years the number of hotels from Serbia represented on this portal has increased significantly. At the end of 2012 there have been registered 3.288 comments which evaluated the service quality of 165 hotels from Serbia. The average vote, on five-degree scale, calculated at the level of all represented hotels at the end of 2012 was 3,92. Considering that Belgrade represents the primarily business, administrative and touristic center of Serbia, on the Belgrade's hotels specimen there has been analyzed the connection between business performances of hotels expressed through indicator TREVPAR and their image on TripAdvisor expressed through average vote determined based on user's comments, as well as in relation with TripAdvisor Popularity Index (TPI. The results show the high degree of correlation between analyzed features on the specimen of Belgrade's hotels, in range of hotels of second (4* and third category (3*. Having in mind the results of conducted research it is obvious that the hotels managers from Serbia should adopt and implement the corresponding procedures of monitoring and adequate reactions on contents on TripAdvisor, considering their influence on behavior of modern consumer in hotels.

Distribution and habitat description of Junín Rail Laterallus tuerosi, Andean Peru

DEFF Research Database (Denmark)

Dinesen, Lars; Chamorro, Alan; Fjeldså, Jon

2017-01-01

Distribution and habitat description of the endangered Junín Rail Laterallus tuerosi were assessed during a field study between 6 and 20 February 2014 in the marshes surrounding Lake Junín in the high Andes of Peru, which is the only known locality for the species. By using point counts and playb......Distribution and habitat description of the endangered Junín Rail Laterallus tuerosi were assessed during a field study between 6 and 20 February 2014 in the marshes surrounding Lake Junín in the high Andes of Peru, which is the only known locality for the species. By using point counts...

A Preliminary Report of Advisor Perceptions of Advising and of a Profession

Science.gov (United States)

Aiken-Wisniewski, Sharon A.; Johnson, Anna; Larson, Joshua; Barkemeyer, Jason

2015-01-01

Practicing advisors may not agree, know, or understand that advising does not meet the scholarly definition of a profession. Through a phenomenological study, members of NACADA: The Global Community for Academic Advising were invited to describe the position of academic advisor. The data gathered were used to address two research questions:…

2001 Joint ADVISOR/PSAT Vehicle Systems Modeling User's Conference Proceedings (CD)

International Nuclear Information System (INIS)

Markel, T.

2001-01-01

The 2001 Joint ADVISOR/PSAT Vehicle Systems Modeling User Conference provided an opportunity for engineers in the automotive industry and the research environment to share their experiences in vehicle systems modeling using ADVISOR and PSAT. ADVISOR and PSAT are vehicle systems modeling tools developed and supported by the National Renewable Energy Laboratory and Argonne National Laboratory respectively with the financial support of the US Department of Energy. During this conference peers presented the results of studies using the simulation tools and improvements that they have made or would like to see in the simulation tools. Focus areas of the presentations included Control Strategy, Model Validation, Optimization and Co-Simulation, Model Development, Applications, and Fuel Cell Vehicle Systems Analysis. Attendees were offered the opportunity to give feedback on future model development plans

Safety review advisor

International Nuclear Information System (INIS)

Boshers, J.A.; Uhrig, R.E.; Alguindigue, I.A.; Burnett, C.G.

1991-01-01

The University of Tennessee's Nuclear Engineering department, in cooperation with the Tennessee Valley Authority (TVA), is evaluating the feasibility of utilizing an expert system to aid in 10CFR50.59 evaluations. This paper discusses the history of 10CFR50.59 reviews, and details the development approach used in the construction of a prototype Safety Review Advisor (SRA). The goals for this expert system prototype are to aid the engineer in the evaluation process by directing his attention to the appropriate critical issues, increase the efficiency, consistency, and thoroughness of the evaluation process, and provide a foundation of appropriate Safety Analysis Report (SAR) references for the reviewer

78 FR 11865 - President's Board of Advisors on Historically Black Colleges and Universities

Science.gov (United States)

2013-02-20

.... Brown, Jr., White House Initiative on Historically Black Colleges and Universities, U.S. Department of... DEPARTMENT OF EDUCATION President's Board of Advisors on Historically Black Colleges and Universities AGENCY: U.S. Department of Education, President's Board of Advisors on Historically Black Colleges...

78 FR 14297 - President's Board of Advisors on Historically Black Colleges and Universities

Science.gov (United States)

2013-03-05

... DEPARTMENT OF EDUCATION President's Board of Advisors on Historically Black Colleges and... Board of Advisors on Historically Black Colleges and Universities scheduled for March 6, 2013, and... for a date to be announced in the future. FOR FURTHER INFORMATION CONTACT: John P. Brown, Designated...

76 FR 45555 - Nominations to the FIFRA Scientific Advisory Panel; Request for Comments

Science.gov (United States)

2011-07-29

... data of persons nominated to serve on the Scientific Advisory Panel (SAP) established under section 25... and the NSF nominate scientists to fill vacancies occurring on the Panel. The Agency requested... Health Science Advisor in the Division of Specialized Information Services at the National Library of...

Potential role of proteasome on c-jun related signaling in hypercholesterolemia induced atherosclerosis

Directory of Open Access Journals (Sweden)

Erdi Sozen

2014-01-01

Full Text Available Atherosclerosis and its complications are major causes of death all over the world. One of the major risks of atherosclerosis is hypercholesterolemia. During atherosclerosis, oxidized low density lipoprotein (oxLDL regulates CD36-mediated activation of c-jun amino terminal kinase-1 (JNK1 and modulates matrix metalloproteinase (MMP induction which stimulates inflammation with an invasion of monocytes. Additionally, inhibition of proteasome leads to an accumulation of c-jun and phosphorylated c-jun and activation of activator protein-1 (AP-1 related increase of MMP expression. We have previously reported a significant increase in cluster of differentiation 36 (CD36 mRNA levels in hypercholesterolemic rabbits and shown that vitamin E treatment prevented the cholesterol induced increase in CD36 mRNA expression. In the present study, our aim is to identify the signaling molecules/transcription factors involved in the progression of atherosclerosis following CD36 activation in an in vivo model of hypercholesterolemic (induced by 2% cholesterol containing diet rabbits. In this direction, proteasomal activities by fluorometry and c-jun, phospo c-jun, JNK1, MMP-9 expressions by quantitative RT-PCR and immunoblotting were tested in aortic tissues. The effects of vitamin E on these changes were also investigated in this model. As a result, c-jun was phosphorylated following decreased proteasomal degradation in hypercholesterolemic group. MMP-9 expression was also increased in cholesterol group rabbits contributing to the development of atherosclerosis. In addition, vitamin E showed its effect by decreasing MMP-9 levels and phosphorylation of c-jun.

c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2

International Nuclear Information System (INIS)

Vanhara, Petr; Bryja, Vitezslav; Horvath, Viktor; Kozubik, Alois; Hampl, Ales; Smarda, Jan

2007-01-01

c-Jun is one of the major components of the activating protein-1 (AP-1), the transcription factor that participates in regulation of proliferation, differentiation, and apoptosis. In this study, we explored functional interactions of the c-Jun protein with several regulators of the G1/S transition in serum-deprived v-myb-transformed chicken monoblasts BM2. We show that the c-Jun protein induces expression of cyclin A, thus up-regulating activity of cyclin A-associated cyclin-dependent kinase 2 (CDK2), and causing massive programmed cell death of starved BM2cJUN cells. Specific inhibition of CDK2 suppresses frequency of apoptosis of BM2cJUN cells. We conclude that up-regulation of cyclin A expression and CDK2 activity can represent important link between the c-Jun protein, cell cycle machinery, and programmed cell death pathway in leukemic cells

THE ROLE OF 'PROFESSIONAL ADVISORS ON FINANCIAL MATTERS' IN ENTREPRENEURIAL NETWORKS

OpenAIRE

KIM KLYVER; KEVIN HINDLE

2010-01-01

This study investigated the influence that 'professional advisors on financial matters' have in comparison with other people with whom entrepreneurs discuss their venture. Based on follow-up surveys completed in relation to the Danish participation in the Global Entrepreneurship Monitor (GEM) survey, it was found that professional advisors on financial matters only play a minor role in the two early phases of the entrepreneurial process before the venture is actually started. It was further r...

The fingerprint elements analysis on the provenance relation between ancient chinese Ru porcelain and Jun porcelain

International Nuclear Information System (INIS)

Zhao Weijuan; Xie Jianzhong; Li Guoxia; Gao Zhengyao; Li Rongwu; Zhang Bin; Feng Songlin; Huang Zhongxiang; Jia Xiuqin; Han Song

2002-01-01

The 46 samples of glazes and bodies of the ancient Chinese Ru porcelain, Jun Porcelain and imitative porcelain were analyzed by neutron activation analysis (NAA). The contents of 36 elements for each sample were measured, the eight elements were chosen as the fingerprint elements to complete scatter analysis. The result showed that the ancient Chinese Ru porcelain and Jun porcelain had almost identical and stable sources of raw materials. The close provenance relation between ancient Chinese Ru porcelain and Jun porcelain was preliminarily verified. It is found that most modern Jun porcelain samples were similar to the ancient Chinese Jun porcelain, three modern Ru porcelain samples were similar to the ancient Chinese Ru porcelain. Jingdezhen porcelain has no relation to Ru porcelain and Jun porcelain

Niclosamide enhances ROS-mediated cell death through c-Jun activation.

Science.gov (United States)

Lee, Sae-lo-oom; Son, A-Rang; Ahn, Jiyeon; Song, Jie-Young

2014-06-01

Radiotherapy is an effective treatment modality in the clinical treatment of cancers, and has been combined with chemotherapy in order to improve therapeutic efficacy. Therefore, we aimed to develop small molecules that enhance the cytotoxic effects of radiotherapy. In this study, we provide evidence that niclosamide is an effective radiosensitizer in non-small cell lung cancer cells. Using a cell-based high-throughput viability screen of 1040 compounds in combination with γ-ionizing radiation (IR), we found niclosamide, an FDA-approved antihelminthic agent, had a radiosensitizing effect on H1299 human lung cancer cells. Pretreatment with niclosamide enhanced IR- induced cell death of H1299 in a dose-dependent manner via apoptosis compared with IR or niclosamide alone. The combined treatment induced significantly more phosphorylation of p38 MAPK and c-Jun in H1299 cells than IR or niclosamide alone. Since IR induces apoptosis through generation of reactive oxygen species (ROS), hydrogen peroxide (H2O2) was employed as another ROS generator and we found that niclosamide also sensitized cells to H2O2. Niclosamide pretreatment also induced c-Jun and its phosphorylation in the presence of H2O2, thereby enhancing apoptosis. N-acetyl-L-cysteine (NAC) treatment abolished both cell death and c-Jun activation induced by the combination treatments. Knockdown of c-Jun also decreased PARP cleavage and clonogenic cell survival in niclosamide- and IR-treated H1299 cells. Our findings suggest that niclosamide could be a promising radiosensitizer in lung cancer patients through activation of the p38 MAPK-c-Jun axis. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Factors leading to the involvement of Forensic Advisors in the Belgian criminal justice system.

Science.gov (United States)

Bitzer, Sonja

2018-04-01

Forensic Advisors at the National Institute for Criminalistics and Criminology in Brussels act as advising body to the magistrate regarding analytical possibilities and the usefulness of trace analysis in a case. Initially, their function was devised to assist in complex murder cases with unknown offender. However, in a previous study, the increasing diversity of the cases they are requested for has been observed (Bitzer et al., in press). In order to deepen our understanding of the decision steps in the criminal investigation process, the decision to involve a Forensic Advisor and the factors leading to their involvement were evaluated. The study focused on homicide, robbery and burglary cases with and without requests for a Forensic Advisor between January 2014 and June 2016. The factors were categorised into five knowledge dimensions: strategic, immediate, physical, criminal and utility. Decision tree modelling was carried out in order to identify the factors influencing the request for a Forensic Advisor in the case. The decision to request a Forensic Advisor differs between different types of offences. It also depends on the complexity of the case in terms of the number of traces and objects collected at the crime scene, and the availability of witness reports. Indeed, Forensic Advisors take the role of trace analysis coordinator by providing an overview of all available traces, objects, analyses and results. According to the principal implication factors and the performed case study, the contribution of Forensic Advisors consists mainly in summarising all information and advise on potential additional analyses. This might be explained by a loss of overview of the information and the possibilities regarding trace analysis by the magistrate responsible of the case. Copyright © 2018 Elsevier B.V. All rights reserved.

Guide to good practices for the selection, training, and qualification of shift technical advisors

Energy Technology Data Exchange (ETDEWEB)

1993-02-01

The DOE Guide to Good Practices For The Selection, Training, and Qualification of Shift Technical Advisors can be used by any DOE nuclear facility that has implemented the shift technical advisor position. DOE Order 5480-20, ``Personnel Selection, Qualification, Training, and Staffing Requirements at DOE Reactor and Non-Reactor Nuclear Facilities,`` states that only Category A reactors must use shift technical advisor position. However, many DOE nuclear facilities have implemented the shift technical advisor position to provide independent on-shift technical advice and counsel to the shift operating personnel to help determine cause and mitigation of facility accidents. Those DOE nuclear facilities that have implemented or are going to implement the shift technical advisor position will find this guide useful. This guide addresses areas that may be covered by other training programs. In these cases, it is unnecessary (and undesirable) to duplicate these areas in the STA training program as long as the specific skills and knowledge essential for STAs are addressed. The guide is presented based on the premise that the trainee has not completed any facility-specific training other than general employee training.

Viewpoints of students of Shahid Sadoughi University of Medical Sciences regarding their academic advisors

Directory of Open Access Journals (Sweden)

M.H Fallah Yakhdani

2012-02-01

Results: The majority of samples were from Nursing, Midwifery, and Public Health School and a few from Faculty of Medicine. The majority of students (41.8% agreed to have the same advisor from the first term to the last. Also the results showed that the functions of advisors were poor in the areas of constant supervision and monitoring of students’ educational status (35.8%, preparing the timetable for performing the personal or group counseling (41.8% and providing counseling sessions according to the timetable (42.3%. But their functions were fair in the areas of acceptable guidance of students in the educational problems (35.1%, and the advisor’s familiarity to educational regulations (43.9%. It is necessary to note that the advisor's ability in making the intimate relationship with students (37.1%, and the advisors’ motivation and tendency to guidance and counseling (30.1% were the two items evaluated excellent by students. Conclusion: It is necessary that advisors make the students familiar with educational regulations at the first semester of higher education. Also, the policies and regulations for advisors will clarify their activities and will help them to perform better.

Safety review advisor

International Nuclear Information System (INIS)

Boshers, J.A.; Alguindigue, I.E.; Uhrig, R.E.

1989-01-01

The University of Tennessee's Nuclear Engineering Department, in cooperation with the Tennessee Valley Authority (TVA), is evaluating the feasibility of utilizing an expert system to aid in 10CFR50.59 evaluations. This paper discusses the history of 10CFR50.59 reviews, and details the development approach used in the construction of a prototype Safety Review Advisor (SRA). The goals for this expert system prototype are to (1) aid the engineer in the evaluation process by directing his attention to the appropriate critical issues, (2) increase the efficiency, consistency, and thoroughness of the evaluation process, and (3) provide a foundation of appropriate Safety Analysis Report (SAR) references for the reviewer. 6 refs., 2 figs

Distinguish of Famous Jun Porcelain in Ancient and Present Age by INAA and BP Neural Network

International Nuclear Information System (INIS)

Li Guoxia; Liang Xianhua; Zhao Weijuan; Sun Hongwei; Guo Min; Xie Jianzhong; Gao Zhengyao; Cui Pengfei; Yang Dawei; Li rongwu; Zhao Qingyun; Sun Xinmin; Zhao Wenjun; Feng Songlin

2010-01-01

Forty samples of Jun porcelain from an ancient Juntai kiln and 3 modern Jun kilns (Kongjia, Miaojia and Xinghang) were selected and analyzed for 25 elements by INAA.The data were trained and forecasted by BP neural network. The results indicate that the network can distinguish unknown body and glaze samples of the official Jun porcelain and the modern top-grade Jun porcelain after proper training. (authors)

78 FR 46381 - Calamos Advisors LLC and Calamos ETF Trust; Notice of Application

Science.gov (United States)

2013-07-31

... Advisors LLC and Calamos ETF Trust; Notice of Application July 24, 2013. AGENCY: Securities and Exchange... sections 12(d)(1)(A) and (B) of the Act. Applicants: Calamos Advisors LLC (``Adviser'') and Calamos ETF... series of the Trust will be the Calamos Focus Growth ETF (the ``Initial Fund''), the investment objective...

GSA Advisors' Self-Efficacy Related to LGBT Youth of Color and Transgender Youth

Science.gov (United States)

Poteat, V. Paul; Scheer, Jillian R.

2016-01-01

Gay-Straight Alliances (GSAs) serve lesbian, gay, bisexual, transgender (LGBT) and heterosexual youth from diverse backgrounds. Although some attention has been given to youth members in general, little attention has been given to adult advisors. Among 47 GSA advisors from 33 high schools (39 cisgender female, 8 cisgender male), the authors…

How do incentives lead to deception in advisor-client interactions? Explicit and implicit strategies of self-interested deception.

Science.gov (United States)

Mackinger, Barbara; Jonas, Eva

2012-01-01

When confronted with important questions we like to rely on the advice of experts. However, uncertainty can occur regarding advisors' motivation to pursue self-interest and deceive the client. This can especially occur when the advisor has the possibility to receive an incentive by recommending a certain alternative. We investigated how the possibility to pursue self-interest led to explicit strategic behavior (bias in recommendation and transfer of information) and to implicit strategic behavior (bias in information processing: evaluation and memory). In Study 1 explicit strategic behavior could be identified: self-interested advisors recommended more often the self-serving alternative and transferred more self-interested biased information to their client compared to the advisor without specific interest. Also deception through implicit strategic behavior was identified: self-interested advisors biased the evaluation of information less in favor of the client compared to the control group. Self-interested advisors also remembered conflicting information regarding their self-interest worse compared to advisors without self-interest. In Study 2 beside self-interest we assessed accountability which interacted with self-interest and increased the bias: when accountability was high advisor's self-interest led to higher explicit strategic behavior (less transfer of conflicting information), and to higher implicit strategic behavior (devaluated and remembered less conflicting information). Both studies identified implicit strategic behavior as mediator which can explain the relation between self-interest and explicit strategic behavior. Results of both studies suggest that self-interested advisors use explicit and implicit strategic behavior to receive an incentive. Thus, advisors do not only consciously inform their clients "self-interested," but they are influenced unconsciously by biased information processing - a tendency which even increased with high

Returning to Our Small Wars Roots: Preparing Marine Advisors to Help Other Lands Meet Future Threats

Science.gov (United States)

2012-04-26

1918 uprising. Not surprisingly, the best qualified Marines like Smedley Butler were sent to France, adding to these challenges. When confronted... Robert S. McNamara authorized advisors for each province and advisory teams for each combat battalion. In addition to the increased role advisors...University of Pennsylvania Press, 2009), 51. 17 Ibid, 40. 18 Ibid. 19 Ramsey III, Robert D., Advising Indigenous Forces: American Advisors in

CYP98A22, a phenolic ester 3’-hydroxylase specialized in the synthesis of chlorogenic acid, as a new tool for enhancing the furanocoumarin concentration in Ruta graveolens

Directory of Open Access Journals (Sweden)

Karamat Fazeelat

2012-08-01

Full Text Available Abstract Background Furanocoumarins are molecules with proven therapeutic properties and are produced in only a small number of medicinal plant species such as Ruta graveolens. In vivo, these molecules play a protective role against phytophageous insect attack. Furanocoumarins are members of the phenylpropanoids family, and their biosynthetic pathway is initiated from p-coumaroyl coA. The enzymes belonging to the CYP98A cytochrome P450 family have been widely described as being aromatic meta-hydroxylases of various substrates, such as p-coumaroyl ester derivatives, and are involved in the synthesis of coumarins such as scopoletin. In furanocoumarin-producing plants, these enzymes catalyze the step directly downstream of the junction with the furanocoumarin biosynthetic pathway and might indirectly impact their synthesis. Results In this work, we describe the cloning and functional characterization of the first CYP98A encoding gene isolated from R. graveolens. Using Nicotiana benthamiana as a heterologous expression system, we have demonstrated that this enzyme adds a 3-OH to p-coumaroyl ester derivatives but is more efficient to convert p-coumaroyl quinate into chlorogenic acid than to metabolize p-coumaroyl shikimate. Plants exposed to UV-B stress showed an enhanced expression level of the corresponding gene. The R. graveolens cyp98a22 open reading frame and the orthologous Arabidopsis thaliana cyp98a3 open reading frame were overexpressed in stable transgenic Ruta plants. Both plant series were analyzed for their production of scopoletin and furanocoumarin. A detailed analysis indicates that both genes enhance the production of furanocoumarins but that CYP98A22, unlike CYP98A3, doesn’t affect the synthesis of scopoletin. Conclusions The overexpression of CYP98A22 positively impacts the concentration of furanocoumarins in R. graveolens. This gene is therefore a valuable tool to engineer plants with improved therapeutical values that might

Identification of a novel phosphorylation site in c-jun directly targeted in vitro by protein kinase D

International Nuclear Information System (INIS)

Waldron, Richard T.; Whitelegge, Julian P.; Faull, Kym F.; Rozengurt, Enrique

2007-01-01

Protein kinase D (PKD) phosphorylates the c-jun amino-terminal in vitro at site(s) distinct from JNK [C. Hurd, R.T. Waldron, E. Rozengurt, Protein kinase D complexes with c-jun N-terminal kinase via activation loop phosphorylation and phosphorylates the c-jun N-terminus, Oncogene 21 (2002) 2154-2160], but the sites have not been identified. Here, metabolic 32 P-labeling of c-jun protein in COS-7 cells indicated that PKD phosphorylates c-jun in vivo at a site(s) between aa 43-93, a region containing important functional elements. On this basis, the PKD-mediated phosphorylation site(s) was further characterized in vitro using GST-c-jun fusion proteins. PKD did not incorporate phosphate into Ser63 and Ser73, the JNK sites in GST-c-jun(1-89). Rather, PKD and JNK could sequentially phosphorylate distinct site(s) simultaneously. By mass spectrometry of tryptic phosphopeptides, Ser58 interposed between the JNK-binding portion of the delta domain and the adjacent TAD1 was identified as a prominent site phosphorylated in vitro by PKD. These data were further supported by kinase reactions using truncations or point-mutations of GST-c-jun. Together, these data suggest that PKD-mediated phosphorylation modulates c-jun at the level of its N-terminal functional domains

LIA: An Intelligent Advisor for E-Learning

Science.gov (United States)

Capuano, Nicola; Gaeta, Matteo; Marengo, Agostino; Miranda, Sergio; Orciuoli, Francesco; Ritrovato, Pierluigi

2009-01-01

Intelligent e-learning systems have revolutionized online education by providing individualized and personalized instruction for each learner. Nevertheless, until now very few systems were able to leave academic laboratories and be integrated into real commercial products. One of these few exceptions is the Learning Intelligent Advisor (LIA)…

C-Jun expression in lichen planus, psoriasis, and cutaneous squamous cell carcinoma, an immunohistochemical study.

Science.gov (United States)

Abdou, Asmaa Gaber; Marae, Alaa Hassan; Shoeib, Mohammed; Dawood, Ghada; Abouelfath, Enas

2018-01-01

The AP-1 transcription factor complex is a key player in regulating inflammatory processes, cell proliferation, differentiation, and cell transformation. The aim of the present study is to investigate C-Jun (one of AP-1complex) expression and its proliferative role in skin samples of lichen planus, psoriasis as common inflammatory skin diseases and squamous cell carcinoma using immunohistochemical method. The present study was carried out on skin biopsies of 15 psoriatic patients, 15 lichen planus patients, 15 SCC, and 15 normal skin biopsies. Nuclear expression of C-Jun was detected in basal and few suprabasal layers of epidermis of normal skin. C-Jun was expressed in the whole epidermal layers of both psoriasis (14/15) and lichen planus (15/15) in addition to its expression in lymphocytic infiltrate in the latter in about half of cases (8/15). C-Jun was also expressed in 93.3% (14/15) of SCC in a percentage lower than that of psoriasis, lichen planus, and normal skin. The percentage of C-Jun expression in SCC was significantly associated with an early stage (p = 0.000), free surgical margins (p = 0.022), and small tumour size (p = 0.003). The marked reduction of C-Jun in SCC in comparison to normal skin and inflammatory skin dermatoses may refer to its tumour suppressor activity. C-Jun expression in SCC carries favourable prognosis. Absence of significant association between C-Jun and Ki-67 either in SCC or inflammatory skin diseases indicates that it does not affect proliferative capacity of cells.

SPILC: An expert student advisor

Science.gov (United States)

Read, D. R.

1990-01-01

The Lamar University Computer Science Department serves about 350 undergraduate C.S. majors, and 70 graduate majors. B.S. degrees are offered in Computer Science and Computer and Information Science, and an M.S. degree is offered in Computer Science. In addition, the Computer Science Department plays a strong service role, offering approximately sixteen service course sections per long semester. The department has eight regular full-time faculty members, including the Department Chairman and the Undergraduate Advisor, and from three to seven part-time faculty members. Due to the small number of regular faculty members and the resulting very heavy teaching loads, undergraduate advising has become a difficult problem for the department. There is a one week early registration period and a three-day regular registration period once each semester. The Undergraduate Advisor's regular teaching load of two classes, 6 - 8 semester hours, per semester, together with the large number of majors and small number of regular faculty, cause long queues and short tempers during these advising periods. The situation is aggravated by the fact that entering freshmen are rarely accompanied by adequate documentation containing the facts necessary for proper counselling. There has been no good method of obtaining necessary facts and documenting both the information provided by the student and the resulting advice offered by the counsellors.

Graded Elevation of c-Jun in Schwann Cells In Vivo: Gene Dosage Determines Effects on Development, Remyelination, Tumorigenesis, and Hypomyelination.

Science.gov (United States)

Fazal, Shaline V; Gomez-Sanchez, Jose A; Wagstaff, Laura J; Musner, Nicolo; Otto, Georg; Janz, Martin; Mirsky, Rhona; Jessen, Kristján R

2017-12-13

Schwann cell c-Jun is implicated in adaptive and maladaptive functions in peripheral nerves. In injured nerves, this transcription factor promotes the repair Schwann cell phenotype and regeneration and promotes Schwann-cell-mediated neurotrophic support in models of peripheral neuropathies. However, c-Jun is associated with tumor formation in some systems, potentially suppresses myelin genes, and has been implicated in demyelinating neuropathies. To clarify these issues and to determine how c-Jun levels determine its function, we have generated c-Jun OE/+ and c-Jun OE/OE mice with graded expression of c-Jun in Schwann cells and examined these lines during development, in adulthood, and after injury using RNA sequencing analysis, quantitative electron microscopic morphometry, Western blotting, and functional tests. Schwann cells are remarkably tolerant of elevated c-Jun because the nerves of c-Jun OE/+ mice, in which c-Jun is elevated ∼6-fold, are normal with the exception of modestly reduced myelin thickness. The stronger elevation of c-Jun in c-Jun OE/OE mice is, however, sufficient to induce significant hypomyelination pathology, implicating c-Jun as a potential player in demyelinating neuropathies. The tumor suppressor P19 ARF is strongly activated in the nerves of these mice and, even in aged c-Jun OE/OE mice, there is no evidence of tumors. This is consistent with the fact that tumors do not form in injured nerves, although they contain proliferating Schwann cells with strikingly elevated c-Jun. Furthermore, in crushed nerves of c-Jun OE/+ mice, where c-Jun levels are overexpressed sufficiently to accelerate axonal regeneration, myelination and function are restored after injury. SIGNIFICANCE STATEMENT In injured and diseased nerves, the transcription factor c-Jun in Schwann cells is elevated and variously implicated in controlling beneficial or adverse functions, including trophic Schwann cell support for neurons, promotion of regeneration, tumorigenesis

c-Jun Proto-Oncoprotein Plays a Protective Role in Lung Epithelial Cells Exposed to Staphylococcal α-Toxin

Directory of Open Access Journals (Sweden)

Alejandro J. Moyano

2018-05-01

Full Text Available c-Jun is a member of the early mammalian transcriptional regulators belonging to the AP-1 family, which participates in a wide range of cellular processes such as proliferation, apoptosis, tumorigenesis, and differentiation. Despite its established role in cell survival upon stress, its participation in the stress response induced by bacterial infections has been poorly investigated. To study the potential role of c-Jun in this context we choose the widely studied α-toxin produced by Staphylococcus aureus, a pore-forming toxin that is a critical virulence factor in the pathogenesis of these bacteria. We analyzed the effect of α-toxin treatment in the activation, expression, and protein levels of c-Jun in A549 lung epithelial cells. Furthermore, we explored the role of c-Jun in the cellular fate after exposure to α-toxin. Our results show that staphylococcal α-toxin per se is able to activate c-Jun by inducing phosphorylation of its Serine 73 residue. Silencing of the JNK (c-Jun N-terminal Kinase signaling pathway abrogated most of this activation. On the contrary, silencing of the ERK (Extracellular Signal-Regulated Kinase pathway exacerbated this response. Intriguingly, while the exposure to α-toxin induced a marked increase in the levels of c-Jun transcripts, c-Jun protein levels noticeably decreased in the same time-frame as a consequence of active proteolytic degradation through the proteasome-dependent pathway. In addition, we established that c-Jun promoted cell survival when cells were challenged with α-toxin. Similarly, c-Jun phosphorylation was also induced in cells upon intoxication with the cytolysin produced by Vibrio cholerae in a JNK-dependent manner, suggesting that c-Jun-JNK axis would be a conserved responsive cellular pathway to pore-forming toxins. This study contributes to understanding the role of the multifaceted c-Jun proto-oncoprotein in cell response to bacterial pore-forming toxins, positioning it as a relevant

Sierra Leone Journal of Biomedical Research Vol. 2 (1) pp. 17-22 ...

African Journals Online (AJOL)

2010-06-22

Jun 22, 2010 ... experts to define health as more than absence ... life (Wilmore and Costil, 1994). Akdur et ... reducing illness and increasing wellness in the .... agility, flexibility, body fat and balance was ... improving work force and efficiency.

Rapid and preferential activation of the c-jun gene during the mammalian UV response

International Nuclear Information System (INIS)

Devary, Y.; Gottlieb, R.A.; Lau, L.F.; Karin, M.

1991-01-01

Exposure of mammalian cells to DNA-damaging agents leads to activation of a genetic response known as the UV response. Because several previously identified UV-inducible genes contain AP-1 binding sites within their promoters, we investigated the induction of AP-1 activity by DNA-damaging agents. We found that expression of both c-jun and c-fos, which encode proteins that participate in formation of the AP-1 complex, is rapidly induced by two different DNA-damaging agents: UV and H2O2. Interestingly, the c-jun gene is far more responsive to UV than any other immediate-early gene that was examined, including c-fos. Other jun and fos genes were only marginally affected by UV or H2O2. Furthermore, UV is a much more efficient inducer of c-jun than phorbol esters, the standard inducers of c-jun expression. This preferential response of the c-jun gene is mediated by its 5' control region and requires the TPA response element, suggesting that this element also serves as an early target for the signal transduction pathway elicited by DNA damage. Both UV and H2O2 lead to a long-lasting increase in AP-1 binding activity, suggesting that AP-1 may mediate the induction of other damage-inducible genes such as human collagenase

c-Jun controls the efficiency of MAP kinase signaling by transcriptional repression of MAP kinase phosphatases

International Nuclear Information System (INIS)

Sprowles, Amy; Robinson, Dan; Wu Yimi; Kung, H.-J.; Wisdom, Ron

2005-01-01

The mammalian JNK signaling pathway regulates the transcriptional response of cells to environmental stress, including UV irradiation. This signaling pathway is composed of a classical MAP kinase cascade; activation results in phosphorylation of the transcription factor substrates c-Jun and ATF2, and leads to changes in gene expression. The defining components of this pathway are conserved in the fission yeast S. pombe, where the genetic studies have shown that the ability of the JNK homolog Spc1 to be activated in response to UV irradiation is dependent on the presence of the transcription factor substrate Atf1. We have used genetic analysis to define the role of c-Jun in activation of the mammalian JNK signaling pathway. Our results show that optimal activation of JNK requires the presence of its transcription factor substrate c-Jun. Mutational analysis shows that the ability of c-Jun to support efficient activation of JNK requires the ability of Jun to bind DNA, suggesting a transcriptional mechanism. Consistent with this, we show that c-Jun represses the expression of several MAP kinase phosphatases. In the absence of c-Jun, the increased expression of MAP kinase phosphatases leads to impaired activation of the ERK, JNK, and p38 MAP kinases after pathway activation. The results show that one function of c-Jun is to regulate the efficiency of signaling by the ERK, p38, and JNK MAP kinases, a function that is likely to affect cellular responses to many different stimuli

PI in the sky: The astronaut science advisor on SLS-2

Science.gov (United States)

Hazelton, Lyman R.; Groleau, Nicolas; Frainier, Richard J.; Compton, Michael M.; Colombano, Silvano P.; Szolovits, Peter

1994-01-01

The Astronaut Science Advisor (ASA, also known as Principal-Investigator-in-a-Box) is an advanced engineering effort to apply expert systems technology to experiment monitoring and control. Its goal is to increase the scientific value of information returned from experiments on manned space missions. The first in-space test of the system will be in conjunction with Professor Larry Young's (MIT) vestibulo-ocular 'Rotating Dome' experiment on the Spacelab Life Sciences 2 mission (STS-58) in the Fall of 1993. In a cost-saving effort, off-the-shelf equipment was employed wherever possible. Several modifications were necessary in order to make the system flight-worthy. The software consists of three interlocking modules. A real-time data acquisition system digitizes and stores all experiment data and then characterizes the signals in symbolic form; a rule-based expert system uses the symbolic signal characteristics to make decisions concerning the experiment; and a highly graphic user interface requiring a minimum of user intervention presents information to the astronaut operator. Much has been learned about the design of software and user interfaces for interactive computing in space. In addition, we gained a great deal of knowledge about building relatively inexpensive hardware and software for use in space. New technologies are being assessed to make the system a much more powerful ally in future scientific research in space and on the ground.

2001 Joint ADVISOR/PSAT Vehicle Systems Modeling User's Conference Proceedings (CD)

Energy Technology Data Exchange (ETDEWEB)

Markel, T.

2001-08-01

The 2001 Joint ADVISOR/PSAT Vehicle Systems Modeling User Conference provided an opportunity for engineers in the automotive industry and the research environment to share their experiences in vehicle systems modeling using ADVISOR and PSAT. ADVISOR and PSAT are vehicle systems modeling tools developed and supported by the National Renewable Energy Laboratory and Argonne National Laboratory respectively with the financial support of the US Department of Energy. During this conference peers presented the results of studies using the simulation tools and improvements that they have made or would like to see in the simulation tools. Focus areas of the presentations included Control Strategy, Model Validation, Optimization and Co-Simulation, Model Development, Applications, and Fuel Cell Vehicle Systems Analysis. Attendees were offered the opportunity to give feedback on future model development plans.

BUSCA-JUN91 reference manual

International Nuclear Information System (INIS)

Ramsdale, S.A.; Guentay, S.; Friederichs, H.G.

1995-02-01

BUSCA models the decontamination of a bubble as it rises through a water pool. The bubble may contain a mixture of non-condensable gases, steam, iodine vapor and aerosol particles. The bubble thermal-hydraulics are modeled as well as the removal of soluble vapor and aerosol contaminants. The code was originally developed at SRD (part of the UK Atomic Energy Authority) during the mid 1980's. A description of an early version of the code was presented in the BUSCA-JUN90 Reference Manual. Since then, the code has been further enhanced by collaboration within the European Pool Scrubbing Group and additional mechanisms included in its calculations. In particular, PSI (Paul Scherrer Institute, Wuerenlingen) has converted the original FACSIMILE code into FORTRAN and added different bubble initial volume, geometry and bubble rise speed options, UPM (Universidad Politecnica de Madrid) has added the bubble breakup modelling and SRD has added the cluster and plume features. This report describes the BUSCA code version JUN91 which treats the bubble hydrodynamics and removal of aerosol particles and soluble gas in an attempt to calculate the decontamination factor (mass in/mass out), including its input and output requirements. It must be stressed that the development of BUSCA is an on-going project. Currently SRD and PSI have added additional models in their own versions. (author) 3 figs., 39 refs

To Whistleblow or Not to Whistleblow: Affective and Cognitive Differences in Reporting Peers and Advisors.

Science.gov (United States)

McIntosh, Tristan; Higgs, Cory; Turner, Megan; Partlow, Paul; Steele, Logan; MacDougall, Alexandra E; Connelly, Shane; Mumford, Michael D

2017-09-20

Traditional whistleblowing theories have purported that whistleblowers engage in a rational process in determining whether or not to blow the whistle on misconduct. However, stressors inherent to whistleblowing often impede rational thinking and act as a barrier to effective whistleblowing. The negative impact of these stressors on whistleblowing may be made worse depending on who engages in the misconduct: a peer or advisor. In the present study, participants are presented with an ethical scenario where either a peer or advisor engages in misconduct, and positive and the negative consequences of whistleblowing are either directed to the wrongdoer, department, or university. Participant responses to case questions were evaluated for whistleblowing intentions, moral intensity, metacognitive reasoning strategies, and positive and negative, active and passive emotions. Findings indicate that participants were less likely to report the observed misconduct of an advisor compared to a peer. Furthermore, the findings also suggest that when an advisor is the source of misconduct, greater negative affect results. Post-hoc analyses were also conducted examining the differences between those who did and did not intend to blow the whistle under the circumstances of either having to report an advisor or peer. The implications of these findings for understanding the complexities involved in whistleblowing are discussed.

Writing a Thesis : A Guide for Scientific Reports

OpenAIRE

Engdahl, Ingrid; Sandqvist, Karin

2012-01-01

This guide is an introduction to one way to write scientific reports, the way we have been using and taught to our students in Teacher Education Programmes and Child and Youth Studies. It includes how to structure the text, suggested content to go under each heading, some rules about quotes and references, cooperation with the advisor and with fellow students and, finally, guides for the thesis seminar, an agenda for the seminar and advice for the opponent(s) and respondent(s). The references...

Team of Advisors: The Social Science of Advice in Homeland and National Security

Science.gov (United States)

2017-03-01

choice they have to make.”19 While these biases are subconscious and unavoidable, they cannot serve as a crutch to explain away quick, uninformed or...eradicate the influence of biases and heuristics as described by Kahneman, leaders can take steps to reduce the risk of these subconscious influences...hidden bias . Advisors play a role in identifying, recognizing and mitigating the risks inherent to subconsciously relying on heuristics. Third, advisors

Pancreatic β-cells activate a JunB/ATF3-dependent survival pathway during inflammation

DEFF Research Database (Denmark)

Gurzov, E N; Barthson, J; Marhfour, I

2012-01-01

Destruction of insulin-producing pancreatic β-cells by local autoimmune inflammation is a hallmark of type 1 diabetes. Histochemical analysis of pancreases from non-obese diabetic mice indicated activation of the transcription factor JunB/AP-1 (activator protein-1) after autoimmune infiltration......-cells and human islet cells against pro-inflammatory mediators. These results were confirmed in genetically modified islets derived from Ubi-JunB transgenic mice. Our findings identify ATF3 as a novel downstream target of JunB in the survival mechanism of β-cells under inflammatory stress....

Scientific Staff Attestation in Pedagogic and Psychological Disciplines

Directory of Open Access Journals (Sweden)

D. I. Feldshtein

2012-01-01

Full Text Available The paper is devoted to the quality issue of the research conducted by the candidates for a scientific degree in pedagogy and psychology. The author – Chairman of the Expert Council in Pedagogy and Psychology of the Higher Attestation Commission and Vice President of the Russian Academy of Education –points out once again that awarding the scientific degree involves both the assessment of the research work and validation of the candidate’s contribution to the scientific society: publications, conference and symposium presentations, participation in discussions, etc. The paper exemplifies and analyzes the shortcomings of the thesis research: methodological illiteracy, incorrect wording, irrelevant and narrow themes and hypotheses, obvious borrowing of ideas, lack of novelty. The author lays the blame for the undue level of theses on the candidates for a degree, as well as the expert society – the department and laboratory staff, scientific and dissertation councils, scientific advisors, opponents and consult- ants, and experts of the Higher Attestation Commission. The paper suggests the correcting ways to improve the current situation in theses preparation, its defense and approval. 

Scientific Staff Attestation in Pedagogic and Psychological Disciplines

Directory of Open Access Journals (Sweden)

D. I. Feldshtein

2015-02-01

Full Text Available The paper is devoted to the quality issue of the research conducted by the candidates for a scientific degree in pedagogy and psychology. The author – Chairman of the Expert Council in Pedagogy and Psychology of the Higher Attestation Commission and Vice President of the Russian Academy of Education –points out once again that awarding the scientific degree involves both the assessment of the research work and validation of the candidate’s contribution to the scientific society: publications, conference and symposium presentations, participation in discussions, etc. The paper exemplifies and analyzes the shortcomings of the thesis research: methodological illiteracy, incorrect wording, irrelevant and narrow themes and hypotheses, obvious borrowing of ideas, lack of novelty. The author lays the blame for the undue level of theses on the candidates for a degree, as well as the expert society – the department and laboratory staff, scientific and dissertation councils, scientific advisors, opponents and consult- ants, and experts of the Higher Attestation Commission. The paper suggests the correcting ways to improve the current situation in theses preparation, its defense and approval. 

Si-Jun-Zi Decoction Treatment Promotes the Restoration of Intestinal Function after Obstruction by Regulating Intestinal Homeostasis

Directory of Open Access Journals (Sweden)

Xiangyang Yu

2014-01-01

Full Text Available Intestinal obstruction is a common disease requiring abdominal surgery with significant morbidity and mortality. Currently, an effective medical treatment for obstruction, other than surgical resection or decompression, does not exist. Si-Jun-Zi Decoction is a famous Chinese medicine used to replenish qi and invigorate the functions of the spleen. Modern pharmacological studies show that this prescription can improve gastrointestinal function and strengthen immune function. In this study, we investigated the effects of a famous Chinese herbal formula, Si-Jun-Zi Decoction, on the restoration of intestinal function after the relief of obstruction in a rabbit model. We found that Si-Jun-Zi Decoction could reduce intestinal mucosal injury while promoting the recovery of the small intestine. Further, Si-Jun-Zi Decoction could regulate the intestinal immune system. Our results suggest that Si-Jun-Zi Decoction promotes the restoration of intestinal function after obstruction by regulating intestinal homeostasis. Our observations indicate that Si-Jun-Zi Decoction is potentially a therapeutic drug for intestinal obstruction.

Undergraduate Students' Perceptions of the Communication Behaviors of Their Advisors and Perceptions of Relational Satisfaction

Science.gov (United States)

Punyanunt-Carter, Narissra; Carter, Stacy

2015-01-01

This study examined the specific interpersonal communication styles and behaviors of advisors and the expectations they have on their advisee's level of satisfaction, as well as what characteristics lead to higher relational satisfaction in the advisor-advisee relationship. A combination of convenience and snowball sampling were utilized to obtain…

A study on optimization of hybrid drive train using Advanced Vehicle Simulator (ADVISOR)

Energy Technology Data Exchange (ETDEWEB)

Same, Adam; Stipe, Alex; Grossman, David; Park, Jae Wan [Department of Mechanical and Aeronautical Engineering, University of California, Davis, One Shields Ave, Davis, CA 95616 (United States)

2010-10-01

This study investigates the advantages and disadvantages of three hybrid drive train configurations: series, parallel, and ''through-the-ground'' parallel. Power flow simulations are conducted with the MATLAB/Simulink-based software ADVISOR. These simulations are then applied in an application for the UC Davis SAE Formula Hybrid vehicle. ADVISOR performs simulation calculations for vehicle position using a combined backward/forward method. These simulations are used to study how efficiency and agility are affected by the motor, fuel converter, and hybrid configuration. Three different vehicle models are developed to optimize the drive train of a vehicle for three stages of the SAE Formula Hybrid competition: autocross, endurance, and acceleration. Input cycles are created based on rough estimates of track geometry. The output from these ADVISOR simulations is a series of plots of velocity profile and energy storage State of Charge that provide a good estimate of how the Formula Hybrid vehicle will perform on the given course. The most noticeable discrepancy between the input cycle and the actual velocity profile of the vehicle occurs during deceleration. A weighted ranking system is developed to organize the simulation results and to determine the best drive train configuration for the Formula Hybrid vehicle. Results show that the through-the-ground parallel configuration with front-mounted motors achieves an optimal balance of efficiency, simplicity, and cost. ADVISOR is proven to be a useful tool for vehicle power train design for the SAE Formula Hybrid competition. This vehicle model based on ADVISOR simulation is applicable to various studies concerning performance and efficiency of hybrid drive trains. (author)

An Exploration of the Relationship between International Students and Their Advisors in U.S. Higher Education Institution

OpenAIRE

Mitra, Shreya

2017-01-01

International students in U.S. academic settings are facing barriers in the path of their academic accomplishments. In higher educational institutions, students work very closely with their academic advisors to solve a definite problem. Dependence on the academic advisor is much more when the advisee is international. Keeping these points in mind, one of the factors that might impact academic environment for an international student is the bonding that they share with their advisor. This rese...

Trends in Defamation Law: Let the Advisor Beware.

Science.gov (United States)

King, Robert D.

1992-01-01

Although most lawsuits brought by students against a college are grounded on contract and due process theories, courts have been willing to consider students' defamation suits using tort theories. Recent changes in defamation law have engendered increased litigation and risk of liability for faculty and advisors. (Author/MSE)

77 FR 5585 - Northwestern Mutual Series Fund, Inc. and Mason Street Advisors, LLC; Notice of Application

Science.gov (United States)

2012-02-03

... SECURITIES AND EXCHANGE COMMISSION [Investment Company Act Release No. 29939; File No. 812-13982] Northwestern Mutual Series Fund, Inc. and Mason Street Advisors, LLC; Notice of Application January 30, 2012... instruments. Applicants: Northwestern Mutual Series Fund, Inc. (``Company'') and Mason Street Advisors, LLC...

Are South African financial advisor addressing the estate planning objectives that are important to their client?

Directory of Open Access Journals (Sweden)

Venter, J.M.P.

2014-07-01

Full Text Available Estate planning is an important aspect of any effective financial plan. When preparing an estate plan several objectives identified by the individual planner, as well as several pieces of legislation have to be considered. In South Africa the actions of financial advisors are regulated by the Financial Advisory and Intermediary Services Act. The act aims to ensure that the financial advisor act in the best interest of his / her client. If the act meets its set objectives there will be an alignment of objectives set by a financial advisor and his / her client. This study investigates the existence of an expectation gap between the estate planning objectives considered to be important by the financial advisor and the importance allocated to these factors by the clients. The study found that there was an expectation gap for three of the objectives that should be considered in the estate plan

How do incentives lead to deception in advisors-client interactions? Explicit and implicit strategies of self-interested deception.

Directory of Open Access Journals (Sweden)

Barbara eMackinger

2012-12-01

Full Text Available When confronted with important questions we like to rely on the advice of experts. However, uncertainty can occur regarding advisors’ motivation to pursue self-interest and deceive the client. This can especially occur when the advisor has the possibility to receive an incentive by recommending a certain alternative. We investigated how the possibility to pursue self-interest led to explicit strategic behavior (bias in recommendation and transfer of information and to implicit strategic behavior (bias in information processing: evaluation and memory. In Study 1 explicit strategic behavior could be identified: Self-interested advisors recommended more often the self-serving alternative and transferred more self-interested biased information to their client compared to the advisor without specific interest. Also deception through implicit strategic behavior was identified: Self-interested advisors biased the evaluation of information less in favor of the client compared to the control group. Self-interested advisors also remembered conflicting information regarding their self-interest worse compared to advisors without self-interest. In Study 2 beside self-interest we assessed accountability which interacted with self-interest and increased the bias: When accountability was high advisor’s self-interest led to higher explicit strategic behavior (less transfer of conflicting information, and to higher implicit strategic behavior (devaluated and remembered less conflicting information. Both studies identified implicit strategic behavior as mediator which can explain the relation between self-interest and explicit strategic behavior. Results of both studies suggest that self-interested advisors use explicit and implicit strategic behavior to receive an incentive. Thus, advisors do not only consciously inform their clients self-interested, but they are influenced unconsciously by biased information processing—a tendency which even increased with

78 FR 30346 - Financial Investors Trust and Hanson McClain Strategic Advisors, Inc.; Notice of Application

Science.gov (United States)

2013-05-22

...] Financial Investors Trust and Hanson McClain Strategic Advisors, Inc.; Notice of Application May 15, 2013... instruments. Applicants: Financial Investors Trust (the ``Trust''), on behalf of the Pathway Advisors... consistent with the public interest and the protection of investors. Applicants seek an exemption under...

The Use of Images in Intelligent Advisor Systems.

Science.gov (United States)

Boulet, Marie-Michele

This paper describes the intelligent advisor system, named CODAMA, used in teaching a university-level systems analysis and design course. The paper discusses: (1) the use of CODAMA to assist students to transfer theoretical knowledge to the practical; (2) details of how CODAMA is applied in conjunction with a computer-aided software engineering…

76 FR 60564 - President's Council of Advisors on Science and Technology; Notice of Meeting: Open Regional...

Science.gov (United States)

2011-09-29

... development. Facility and infrastructure sharing. Policies that could create a fertile innovation environment...; Notice of Meeting: Open Regional Meeting of the President's Council of Advisors on Science and Technology... schedule and summary agenda for an open regional meeting of the President's Council of Advisors on Science...

Crop advisors as climate information brokers: Building the capacity of US farmers to adapt to climate change

Directory of Open Access Journals (Sweden)

Maria Carmen Lemos

2014-01-01

Full Text Available This paper examines the role of crop advisors as brokers of climate information to support US corn farmers to adapt to climatic change. It uses quantitative data collected from a broad survey of crop advisors in the US Corn Belt to examine the factors that shape advisors’ use of (and willingness to provide climate information to their clients. Building upon a general model of climate information usability we argue that advisors’ willingness to provide climate advice to farmers is influenced by three main factors: their information seeking habits and behavior, their experience with innovation in the past, and how climate information interplays with other kinds of information that they provide—especially agronomic advice. We find that advisors’ willingness to provide climate related information depends both on factors at the individual and organizational level and on the type of advice they provide. First, at the individual and organizational levels, advisors who work in supportive organizations and who collaborate with other advisors are more likely to provide climate information. Second, advisors are more likely to provide climate information if it does not interfere with their main profit making business (e.g. provision of agronomic advice. Third, there is a significant positive relationship between trust in a greater number or sources of information and use of climate information. Fourth, the way advisors perceive short- and long-term risk also influences their willingness to provide climate information; the more concerned they are about long-term climate-related risks to farming, the more likely they are to provide (or want to provide advice based on climate information. Differently from other empirical work in the literature, our analytical model suggests that neither negative experiences with climate information in the past nor the high level of uncertainty characteristic of climate information appear to influence advisors

Overexpressed DNA polymerase iota regulated by JNK/c-Jun contributes to hypermutagenesis in bladder cancer.

Science.gov (United States)

Yuan, Fang; Xu, Zhigang; Yang, Mingzhen; Wei, Quanfang; Zhang, Yi; Yu, Jin; Zhi, Yi; Liu, Yang; Chen, Zhiwen; Yang, Jin

2013-01-01

Human DNA polymerase iota (pol ι) possesses high error-prone DNA replication features and performs translesion DNA synthesis. It may be specialized and strictly regulated in normal mammalian cells. Dysregulation of pol ι may contribute to the acquisition of a mutator phenotype. However, there are few reports describing the transcription regulatory mechanism of pol ι, and there is controversy regarding its role in carcinogenesis. In this study, we performed the deletion and point-mutation experiment, EMSA, ChIP, RNA interference and western blot assay to prove that c-Jun activated by c-Jun N-terminal kinase (JNK) regulates the transcription of pol ι in normal and cancer cells. Xeroderma pigmentosum group C protein (XPC) and ataxia-telangiectasia mutated related protein (ATR) promote early JNK activation in response to DNA damage and consequently enhance the expression of pol ι, indicating that the novel role of JNK signal pathway is involved in DNA damage response. Furthermore, associated with elevated c-Jun activity, the overexpression of pol ι is positively correlated with the clinical tumor grade in 97 bladder cancer samples and may contribute to the hypermutagenesis. The overexpressed pol ι-involved mutagenesis is dependent on JNK/c-Jun pathway in bladder cancer cells identifying by the special mutation spectra. Our results support the conclusion that dysregulation of pol ι by JNK/c-Jun is involved in carcinogenesis and offer a novel understanding of the role of pol ι or c-Jun in mutagenesis.

LEGAL STATUS OF ADVISORS IN THE FIELD OF INTELLECTUAL PROPERTY RIGHT IN THE UNITED KINGDOM

Directory of Open Access Journals (Sweden)

Khrystyna Kmetyk

2017-11-01

Full Text Available Purpose: to research the legal status of advisors in the field of intellectual property right in the United Kingdom. In this article an author distinguishes and gives a legal description of the types of advisors in the field of intellectual property right in the United Kingdom. The main provisions of the Rules of Conduct for Patent Attorneys, Ttrade Mark Attorneys and Other Regulated Persons (2015 are considered. Methods: to analyse the legal status of advisors in the field of intellectual property right in the United Kingdom the method of induction, systematic approach, formal legal methods were used. Results: this research provides an opportunity to broaden the understanding of the institute of advisors in the field of intellectual property right (in particular patent attorneys and trademark attorneys in the UK and thus include this knowledge in domestic research on intellectual property right. Conclusions: the majority of types of advisors in the field of intellectual property right in the United Kingdom (patent attorneys, chartered patent attorneys, European patent attorneys, registered trademark attorneys and trademark attorneys, European trademark attorneys, etc. is well-educated professionals in all areas of intellectual property and are able to advise on a wide range of technical and commercial issues in this field. The obtained results will have a positive impact on the reform of the institute of representatives in the field of intellectual property in Ukraine in order to ensure its effectiveness and relevance to the challenges of the present.

Contextualizing Gay-straight Alliances: Student, Advisor, and Structural Factors Related to Positive Youth Development among Members

Science.gov (United States)

Poteat, V. Paul; Yoshikawa, Hirokazu; Calzo, Jerel P.; Gray, Mary L.; DiGiovanni, Craig D.; Lipkin, Arthur; Mundy-Shephard, Adrienne; Perrotti, Jeff; Scheer, Jillian R.; Shaw, Matthew P.

2015-01-01

Gay-straight alliances (GSAs) may promote resilience. Yet, what GSA components predict well-being? Among 146 youth and advisors in 13 GSAs (58% lesbian, gay, bisexual, or questioning; 64% White; 38% received free/reduced-cost lunch), student (demographics, victimization, attendance frequency, leadership, support, control), advisor (years served,…

The adeno-associated virus major regulatory protein Rep78-c-Jun-DNA motif complex modulates AP-1 activity

International Nuclear Information System (INIS)

Prasad, C. Krishna; Meyers, Craig; Zhan Dejin; You Hong; Chiriva-Internati, Maurizio; Mehta, Jawahar L.; Liu Yong; Hermonat, Paul L.

2003-01-01

Multiple epidemiologic studies show that adeno-associated virus (AAV) is negatively associated with cervical cancer (CX CA), a cancer which is positively associated with human papillomavirus (HPV) infection. Mechanisms for this correlation may be by Rep78's (AAV's major regulatory protein) ability to bind the HPV-16 p97 promoter DNA and inhibit transcription, to bind and interfere with the functions of the E7 oncoprotein of HPV-16, and to bind a variety of HPV-important cellular transcription factors such as Sp1 and TBP. c-Jun is another important cellular factor intimately linked to the HPV life cycle, as well as keratinocyte differentiation and skin development. Skin is the natural host tissue for both HPV and AAV. In this article it is demonstrated that Rep78 directly interacts with c-Jun, both in vitro and in vivo, as analyzed by Western blot, yeast two-hybrid cDNA, and electrophoretic mobility shift-supershift assay (EMSA supershift). Addition of anti-Rep78 antibodies inhibited the EMSA supershift. Investigating the biological implications of this interaction, Rep78 inhibited the c-Jun-dependent c-jun promoter in transient and stable chloramphenicol acetyl-transferase (CAT) assays. Rep78 also inhibited c-Jun-augmented c-jun promoter as well as the HPV-16 p97 promoter activity (also c-Jun regulated) in in vitro transcription assays in T47D nuclear extracts. Finally, the Rep78-c-Jun interaction mapped to the amino-half of Rep78. The ability of Rep78 to interact with c-Jun and down-regulate AP-1-dependent transcription suggests one more mechanism by which AAV may modulate the HPV life cycle and the carcinogenesis process

c-Jun binds the N terminus of human TAF(II)250 to derepress RNA polymerase II transcription in vitro.

Science.gov (United States)

Lively, T N; Ferguson, H A; Galasinski, S K; Seto, A G; Goodrich, J A

2001-07-06

c-Jun is an oncoprotein that activates transcription of many genes involved in cell growth and proliferation. We studied the mechanism of transcriptional activation by human c-Jun in a human RNA polymerase II transcription system composed of highly purified recombinant and native transcription factors. Transcriptional activation by c-Jun depends on the TATA-binding protein (TBP)-associated factor (TAF) subunits of transcription factor IID (TFIID). Protein-protein interaction assays revealed that c-Jun binds with high specificity to the largest subunit of human TFIID, TAF(II)250. The region of TAF(II)250 bound by c-Jun lies in the N-terminal 163 amino acids. This same region of TAF(II)250 binds to TBP and represses its interaction with TATA boxes, thereby decreasing DNA binding by TFIID. We hypothesized that c-Jun is capable of derepressing the effect of the TAF(II)250 N terminus on TFIID-driven transcription. In support of this hypothesis, we found that c-Jun increased levels of TFIID-driven transcription in vitro when added at high concentrations to a DNA template lacking activator protein 1 (AP-1) sites. Moreover, c-Jun blocked the repression of TBP DNA binding caused by the N terminus of TAF(II)250. In addition to revealing a mechanism by which c-Jun activates transcription, our studies provide the first evidence that an activator can bind directly to the N terminus of TAF(II)250 to derepress RNA polymerase II transcription in vitro.

78 FR 27444 - Forum Investment Advisors, LLC, et al.;

Science.gov (United States)

2013-05-10

... SECURITIES AND EXCHANGE COMMISSION [Investment Company Act Release No. 30507; 812-13915] Forum Investment Advisors, LLC, et al.; Notice of Application May 6, 2013. AGENCY: Securities and Exchange Commission (``Commission''). ACTION: Notice of an application for an order under section 6(c) of the...

The impact of patient advisors on healthcare outcomes: a systematic review

Directory of Open Access Journals (Sweden)

Anjana E. Sharma

2017-10-01

Full Text Available Abstract Background Patient advisory councils are a way for healthcare organizations to promote patient engagement. Despite mandates to implement patient advisory councils through programs like the Patient-Centered Medical Home (PCMH, there is a paucity of data measuring the impact of patients functioning in advisory roles. Our objective is to investigate whether patient engagement in patient advisory councils is linked to improvements in clinical quality, patient safety or patient satisfaction. Methods We searched PubMed, SCOPUS, CINAHL and Google Scholar for English language publications between November 2002 to August 2015, using a combination of “patient advisor” and “care outcomes” search terms. Article selection utilized dual screening facilitated by DistillerSR software, with group discussion to resolve discordance. Observational studies, randomized controlled trials, and case studies were included that described patients serving in an advisory role where primary outcomes were mentioned. Reference lists of included studies and grey literature searches were conducted. Qualitative thematic analysis was performed to synthesize results. Results Database searching yielded 639 articles total after removing duplicates, with 129 articles meeting full text inclusion criteria. 32 articles were identified for final review, 16 of which were case studies. Advisory roles included patient advisory councils, ad-hoc patient committees, community advisory councils, experience-based co-design, and other. Four practice-based studies from one research group, involving community advisors in the design of public health interventions, found improved clinical outcomes. No prospective experimental studies assessed the impact of patient advisors on patient safety or patient satisfaction. One cluster-randomized RCT showed that patient advisors helped health care planning efforts identify priorities more aligned with the PCMH. Ten case studies reported

Expanding the Use of Time-Based Metering: Multi-Center Traffic Management Advisor

Science.gov (United States)

Landry, Steven J.; Farley, Todd; Hoang, Ty

2005-01-01

Time-based metering is an efficient air traffic management alternative to the more common practice of distance-based metering (or "miles-in-trail spacing"). Despite having demonstrated significant operational benefit to airspace users and service providers, time-based metering is used in the United States for arrivals to just nine airports and is not used at all for non-arrival traffic flows. The Multi-Center Traffic Management Advisor promises to bring time-based metering into the mainstream of air traffic management techniques. Not constrained to operate solely on arrival traffic, Multi-Center Traffic Management Advisor is flexible enough to work in highly congested or heavily partitioned airspace for any and all traffic flows in a region. This broader and more general application of time-based metering is expected to bring the operational benefits of time-based metering to a much wider pool of beneficiaries than is possible with existing technology. It also promises to facilitate more collaborative traffic management on a regional basis. This paper focuses on the operational concept of the Multi-Center Traffic Management Advisor, touching also on its system architecture, field test results, and prospects for near-term deployment to the United States National Airspace System.

A feed-forward regulation of endothelin receptors by c-Jun in human non-pigmented ciliary epithelial cells and retinal ganglion cells.

Directory of Open Access Journals (Sweden)

Junming Wang

Full Text Available c-Jun, c-Jun N-terminal kinase(JNK and endothelin B (ETB receptor have been shown to contribute to the pathogenesis of glaucoma. Previously, we reported that an increase of c-Jun and CCAAT/enhancer binding protein β (C/EBPβ immunohistostaining is associated with upregulation of the ETB receptor within the ganglion cell layer of rats with elevated intraocular pressure (IOP. In addition, both transcription factors regulate the expression of the ETB receptor in human non-pigmented ciliary epithelial cells (HNPE. The current study addressed the mechanisms by which ET-1 produced upregulation of ET receptors in primary rat retinal ganglion cells (RGCs and HNPE cells. Treatment of ET-1 and ET-3 increased the immunocytochemical staining of c-Jun and C/EBPβ in primary rat RGCs and co-localization of both transcription factors was observed. A marked increase in DNA binding activity of AP-1 and C/EBPβ as well as elevated protein levels of c-Jun and c-Jun-N-terminal kinase (JNK were detected following ET-1 treatment in HNPE cells. Overexpression of ETA or ETB receptor promoted the upregulation of c-Jun and also elevated its promoter activity. In addition, upregulation of C/EBPβ augmented DNA binding and mRNA expression of c-Jun, and furthermore, the interaction of c-Jun and C/EBPβ was confirmed using co-immunoprecipitation. Apoptosis of HNPE cells was identified following ET-1 treatment, and overexpression of the ETA or ETB receptor produced enhanced apoptosis. ET-1 mediated upregulation of c-Jun and C/EBPβ and their interaction may represent a novel mechanism contributing to the regulation of endothelin receptor expression. Reciprocally, c-Jun was also found to regulate the ET receptors and C/EBPβ appeared to play a regulatory role in promoting expression of c-Jun. Taken together, the data suggests that ET-1 triggers the upregulation of c-Jun through both ETA and ETB receptors, and conversely c-Jun also upregulates endothelin receptor expression

Supporting Rape Survivors Through the Criminal Injuries Compensation Scheme: An Exploration of English and Welsh Independent Sexual Violence Advisors' Experiences.

Science.gov (United States)

Smith, Olivia; Galey, Jessica

2018-07-01

English and Welsh responses to rape have long been critically examined, leading to attempted improvements in the criminal justice system. Despite this, little attention has been paid to the Criminal Injuries Compensation Scheme (CICS) and the difficulties applying it to rape. To begin addressing this gap, researchers interviewed three, and qualitatively surveyed 22, Independent Sexual Violence Advisors. The findings suggest that CICS may not only reinforce rape myths and disadvantage vulnerable survivors, but is also a source of validation and contributes to survivor justice. The study, while exploratory, therefore, highlights the need for further discussion about rape survivor compensation.

Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins.

Science.gov (United States)

Zenz, Rainer; Eferl, Robert; Kenner, Lukas; Florin, Lore; Hummerich, Lars; Mehic, Denis; Scheuch, Harald; Angel, Peter; Tschachler, Erwin; Wagner, Erwin F

2005-09-15

Psoriasis is a frequent, inflammatory disease of skin and joints with considerable morbidity. Here we report that in psoriatic lesions, epidermal keratinocytes have decreased expression of JunB, a gene localized in the psoriasis susceptibility region PSORS6. Likewise, inducible epidermal deletion of JunB and its functional companion c-Jun in adult mice leads (within two weeks) to a phenotype resembling the histological and molecular hallmarks of psoriasis, including arthritic lesions. In contrast to the skin phenotype, the development of arthritic lesions requires T and B cells and signalling through tumour necrosis factor receptor 1 (TNFR1). Prior to the disease onset, two chemotactic proteins (S100A8 and S100A9) previously mapped to the psoriasis susceptibility region PSORS4, are strongly induced in mutant keratinocytes in vivo and in vitro. We propose that the abrogation of JunB/activator protein 1 (AP-1) in keratinocytes triggers chemokine/cytokine expression, which recruits neutrophils and macrophages to the epidermis thereby contributing to the phenotypic changes observed in psoriasis. Thus, these data support the hypothesis that epidermal alterations are sufficient to initiate both skin lesions and arthritis in psoriasis.

The AP-1 Transcription Factor c-Jun Promotes Arthritis by Regulating Cyclooxygenase-2 and Arginase-1 Expression in Macrophages.

Science.gov (United States)

Hannemann, Nicole; Jordan, Jutta; Paul, Sushmita; Reid, Stephen; Baenkler, Hanns-Wolf; Sonnewald, Sophia; Bäuerle, Tobias; Vera, Julio; Schett, Georg; Bozec, Aline

2017-05-01

Activation of proinflammatory macrophages is associated with the inflammatory state of rheumatoid arthritis. Their polarization and activation are controlled by transcription factors such as NF-κB and the AP-1 transcription factor member c-Fos. Surprisingly, little is known about the role of the AP-1 transcription factor c-Jun in macrophage activation. In this study, we show that mRNA and protein levels of c-Jun are increased in macrophages following pro- or anti-inflammatory stimulations. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment cluster analyses of microarray data using wild-type and c-Jun-deleted macrophages highlight the central function of c-Jun in macrophages, in particular for immune responses, IL production, and hypoxia pathways. Mice deficient for c-Jun in macrophages show an amelioration of inflammation and bone destruction in the serum-induced arthritis model. In vivo and in vitro gene profiling, together with chromatin immunoprecipitation analysis of macrophages, revealed direct activation of the proinflammatory factor cyclooxygenase-2 and indirect inhibition of the anti-inflammatory factor arginase-1 by c-Jun. Thus, c-Jun regulates the activation state of macrophages and promotes arthritis via differentially regulating cyclooxygenase-2 and arginase-1 levels. Copyright © 2017 by The American Association of Immunologists, Inc.

The introduction of forensic advisors in Belgium and their role in the criminal justice system.

Science.gov (United States)

Bitzer, Sonja; Heudt, Laetitia; Barret, Aurélie; George, Lore; Van Dijk, Karolien; Gason, Fabrice; Renard, Bertrand

2018-05-01

Forensic advisors (FA) at the National Institute for Criminalistics and Criminology (NICC), generalists in forensic science, act as an advising body to the magistrate to improve communication between the various parties involved in the investigation: magistrate, police and crime scene investigators, and forensic experts. Their role is manifold, but their main objectives are to optimise trace processing by selecting the most pertinent traces in the context of the case and by advising magistrates on the feasibility of forensic analyses in particular circumstances in regards to the latest technical advances. Despite the absence of a legal framework governing their role and involvement in judicial cases, the demand for their services has increased over the years. Initially, forensic advisors were called for complex homicide cases. Due to the proximity with the Public Prosecutor's Office, the types of offences for which their expertise was sought have become more diverse (mainly including robbery, burglary and sexual assault cases), leading to a diversity in the types of cases handled by the forensic advisors (complex, simple and review). In many of the cases they are requested for, in addition to consulting on the best analytical strategy, forensic advisors also assume the role of case coordinator regarding the seized objects and their respective analyses. Indeed, in the majority of cases treated by the FAs, two or more types of expertise have been requested and performed, either at the internal laboratories of NICC or at external laboratories. This paper explains the role of the forensic advisors in Belgium, the path that let to their current status and problems encountered. Copyright © 2017 The Chartered Society of Forensic Sciences. Published by Elsevier B.V. All rights reserved.

Targeting androgen receptor and JunD interaction for prevention of prostate cancer progression.

Science.gov (United States)

Mehraein-Ghomi, Farideh; Kegel, Stacy J; Church, Dawn R; Schmidt, Joseph S; Reuter, Quentin R; Saphner, Elizabeth L; Basu, Hirak S; Wilding, George

2014-05-01

Multiple studies show that reactive oxygen species (ROS) play a major role in prostate cancer (PCa) development and progression. Previously, we reported an induction of Spermidine/Spermine N(1) -Acetyl Transferase (SSAT) by androgen-activated androgen receptor (AR)-JunD protein complex that leads to over-production of ROS in PCa cells. In our current research, we identify small molecules that specifically block AR-JunD in this ROS-generating metabolic pathway. A high throughput assay based on Gaussia Luciferase reconstitution was used to identify inhibitors of the AR-JunD interaction. Selected hits were further screened using a fluorescence polarization competitor assay to eliminate those that bind to the AR Ligand Binding Domain (LBD), in order to identify molecules that specifically target events downstream to androgen activation of AR. Eleven molecules were selected for studies on their efficacy against ROS generation and growth of cultured human PCa cells by DCFH dye-oxidation assay and DNA fluorescence assay, respectively. In situ Proximity Ligation Assay (PLA), SSAT promoter-luciferase reporter assay, and western blotting of apoptosis and cell cycle markers were used to study mechanism of action of the lead compound. Selected lead compound GWARJD10 with EC(50) 10 μM against ROS production was shown to block AR-JunD interaction in situ as well as block androgen-induced SSAT gene expression at IC(50) 5 μM. This compound had no effect on apoptosis markers, but reduced cyclin D1 protein level. Inhibitor of AR-JunD interaction, GWARJD10 shows promise for prevention of progression of PCa at an early stage of the disease by blocking growth and ROS production. © 2014 Wiley Periodicals, Inc.

CRITERIA FOR CONSULTANT AND ADVISOR IN THE BRAZILIAN POSTGRADUATE SYSTEM.

Science.gov (United States)

Petroianu, Andy

2015-01-01

To review the rules, resolutions and existing documents relating to consultant and advisor to better target the actions of those who exercise these roles. The following documents were consulted: Statute of CAPES, through Decree No. 7692 of March 2, 2012; Ordinance No. 47 of 17/10/1995; Opinion 977 1965 Newton Sucupira; Area Document of Medicine III; Interministerial Ordinance 251 of 2012, based on Decree No. 7642 of 2011 of the Ministry of Science and Technology; CAPES Regiment. The Brazilian Postgraduate system is divided in two different fields, according to its aspects: the "lato sensu" postgraduate, defined as all professional studies performed after the high school graduation; and the "stricto sensu" postgraduate that includes the master degree and the doctorate, both of them different from what is known as MSc or MS and PhD. The Brazilian doctorate is recognized as academic because its purposes include to improve the scientific and the teaching levels of university docents. The master degree has two different objectives one is to be academic and similar to the doctorate; the other is to upgrade professionals to a higher level than specialist or MBA and is denominated professional master degree. The master degrees and the doctorate are designated as courses and may be put together in a structure known as stricto sensu postgraduate program. The complexity of these courses and programs in all the areas of the superior human knowledge requires a large number of professional directly involved with this system and other professionals that attend them, called consultants and advisors. The consultants are counselors, and the advisors are assistants, both of them legally established with the incumbency to aid the postgraduate staff in all their duties. Nothing prevents a person from being a consultant on the situation and advisor on another, even in the same institution. Have knowledge about what being a consultant and advisor is required to exercise the function

March of the Robo-advisors : The potential for global expansion of digital asset management platforms

OpenAIRE

Rättyä, Jere

2016-01-01

This thesis looks into the robo-advisory market in the U.S. and Europe, with the goal of determining the international potential for a Finnish robo-advisor service and inspecting the interest of foreign service providers in the Finnish market. Fintech is becoming increasingly disruptive for the traditional and conservative financial sector, which has resulted in start-ups building their own robo-advisor platform around the world. Traditional wealth management is both expensive and exclusi...

Internet-based intervention for smoking cessation (StopAdvisor) in people with low and high socioeconomic status: a randomised controlled trial.

Science.gov (United States)

Brown, Jamie; Michie, Susan; Geraghty, Adam W A; Yardley, Lucy; Gardner, Benjamin; Shahab, Lion; Stapleton, John A; West, Robert

2014-12-01

groups for the primary (237 [10%] vs 220 [10%] participants; relative risk [RR] 1·06, 95% CI 0·89-1·27; p=0·49) and the secondary (358 [15%] vs 332 [15%] participants; 1·06, 0·93-1·22; p=0·37) outcomes; however, the intervention effect differed across socioeconomic status subsamples (1·44, 0·99-2·09; p=0·0562 and 1·37, 1·02-1·84; p=0·0360, respectively). StopAdvisor helped participants with low socioeconomic status stop smoking compared with the information-only website (primary outcome: 90 [8%] of 1088 vs 64 [6%] of 1054 participants; RR 1·36, 95% CI 1·00-1·86; p=0·0499; secondary outcome: 136 [13%] vs 100 [10%] participants; 1·32, 1·03-1·68, p=0·0267), but did not improve cessation rates in those with high socioeconomic status (147 [12%] of 1233 vs 156 [13%] of 1238 participants; 0·95, 0·77-1·17; p=0·61 and 222 [18%] vs 232 [19%] participants; 0·96, 0·81-1·13, p=0·64, respectively). StopAdvisor was more effective than an information-only website in smokers of low, but not high, socioeconomic status. StopAdvisor could be implemented easily and made freely available, which would probably improve the success rates of smokers with low socioeconomic status who are seeking online support. National Prevention Research Initiative. Copyright © 2014 Brown et al. Open Access article distributed under the terms of CC BY. Published by .. All rights reserved.

Science PhD career preferences: levels, changes, and advisor encouragement.

Directory of Open Access Journals (Sweden)

Henry Sauermann

Full Text Available Even though academic research is often viewed as the preferred career path for PhD trained scientists, most U.S. graduates enter careers in industry, government, or "alternative careers." There has been a growing concern that these career patterns reflect fundamental imbalances between the supply of scientists seeking academic positions and the availability of such positions. However, while government statistics provide insights into realized career transitions, there is little systematic data on scientists' career preferences and thus on the degree to which there is a mismatch between observed career paths and scientists' preferences. Moreover, we lack systematic evidence whether career preferences adjust over the course of the PhD training and to what extent advisors exacerbate imbalances by encouraging their students to pursue academic positions. Based on a national survey of PhD students at tier-one U.S. institutions, we provide insights into the career preferences of junior scientists across the life sciences, physics, and chemistry. We also show that the attractiveness of academic careers decreases significantly over the course of the PhD program, despite the fact that advisors strongly encourage academic careers over non-academic careers. Our data provide an empirical basis for common concerns regarding labor market imbalances. Our results also suggest the need for mechanisms that provide PhD applicants with information that allows them to carefully weigh the costs and benefits of pursuing a PhD, as well as for mechanisms that complement the job market advice advisors give to their current students.

Science PhD career preferences: levels, changes, and advisor encouragement.

Science.gov (United States)

Sauermann, Henry; Roach, Michael

2012-01-01

Even though academic research is often viewed as the preferred career path for PhD trained scientists, most U.S. graduates enter careers in industry, government, or "alternative careers." There has been a growing concern that these career patterns reflect fundamental imbalances between the supply of scientists seeking academic positions and the availability of such positions. However, while government statistics provide insights into realized career transitions, there is little systematic data on scientists' career preferences and thus on the degree to which there is a mismatch between observed career paths and scientists' preferences. Moreover, we lack systematic evidence whether career preferences adjust over the course of the PhD training and to what extent advisors exacerbate imbalances by encouraging their students to pursue academic positions. Based on a national survey of PhD students at tier-one U.S. institutions, we provide insights into the career preferences of junior scientists across the life sciences, physics, and chemistry. We also show that the attractiveness of academic careers decreases significantly over the course of the PhD program, despite the fact that advisors strongly encourage academic careers over non-academic careers. Our data provide an empirical basis for common concerns regarding labor market imbalances. Our results also suggest the need for mechanisms that provide PhD applicants with information that allows them to carefully weigh the costs and benefits of pursuing a PhD, as well as for mechanisms that complement the job market advice advisors give to their current students.

Design and Implementation of an Experimental Cataloging Advisor--Mapper.

Science.gov (United States)

Ercegovac, Zorana; Borko, Harold

1992-01-01

Describes the design of an experimental computer-aided cataloging advisor, Mapper, that was developed to help novice users with the descriptive cataloging of single-sheet maps from U.S. publishers. The human-computer interface is considered, the use of HyperCard is discussed, the knowledge base is explained, and assistance screens are described.…

TEACHER-ADVISORS: Where There's a Skill There's A Way.

Science.gov (United States)

Tamminen, Armas; And Others

This report discusses a program to present the Teacher Advisement Training Model. This model for training teacher-advisors is based on the assumption that tentative commitment to making school a more rewarding experience for all is the first step in starting an effective program. The approach is to help teachers learn specific skills and methods…

National seminar on public information on peaceful uses of nuclear energy - NUCInfo'98. Proceedings. Vol 2. Section B - Scientific and Technical Papers

International Nuclear Information System (INIS)

Dobos, Ion; Comsa, Olivia

1998-01-01

These proceedings published in two volumes contain materials presented at the National Seminar on Public Information on Peaceful uses of Nuclear Energy - NUCInfo'98 - held on 30th September to 2nd October 1998 at Bucharest, Romania. The first volume was dedicated to Public Information. The second volume containing 56 scientific and technical papers is structured in three parts according to the three sessions entitled: B 1 . Sustainable Development - Energy - Environment; B 2 . Nuclear safety, Radioactive Wastes, Radioprotection and Nuclear Safeguards; B 3 . Scientific Research, Technological Development and Applications of the Nuclear Energy in Economic and Social Life. The great majority of the contributions deal with specific public information technical problems and debates on nuclear issues mainly related to radiation monitoring, waste management, air, water and food contamination from accidental radioactive release or from fuel cycle relating activities. Also, several papers discuss the present status of national nuclear program, program management and legal matters in the nuclear field. A number of papers debate the questions related to radiation protection procedures and the safety problems at the Cernavoda NPP based on CANDU type reactors

c-jun-N-Terminal Kinase (JNK) for the Treatment of Amyotrophic Lateral Sclerosis

Science.gov (United States)

2015-03-01

1 AWARD NUMBER: W81XWH-12-1-0431 TITLE: “c-jun-N-Terminal Kinase (JNK) for the Treatment of Amyotrophic Lateral Sclerosis ” PRINCIPAL...TITLE AND SUBTITLE “c-jun-N-Terminal Kinase (JNK) for the Treatment of Amyotrophic Lateral Scelerosis” 5a. CONTRACT NUMBER 5b. GRANT NUMBER... Lateral   Sclerosis ”   Final  Report:  Project  Period  Sept  2012-­‐Dec  2014     Personnel  List:     Feng,  Yangbo

Dissemination of colorectal cancer screening by Filipino American community health advisors: a feasibility study.

Science.gov (United States)

Maxwell, Annette E; Danao, Leda L; Bastani, Roshan

2013-07-01

Filipino Americans underutilize life-saving screening tests for colorectal cancer, resulting in late stage of diagnosis and poor survival relative to other racial/ethnic groups. Education regarding colorectal cancer screening and distribution of free fecal occult blood test (FOBT) kits are evidence-based interventions that can significantly increase screening. However, this community will only benefit if the intervention is broadly disseminated. We assessed the feasibility of promoting colorectal cancer screening in Filipino American community settings working with community health advisors, and the practicality of conducting one-on-one or small group education, in addition to passing out free FOBT kits. Twenty community health advisors from 4 organizations engaged in recruitment and education activities with 132 participants. Community health advisors consistently completed screening questionnaires to establish eligibility and kept logs of FOBT distribution. However, they did not consistently record eligible participants who did not consent to participate. Process checklists that indicated what information was covered in each educational session and postsession follow-up logs were partially completed. Almost all participants reported receipt of intervention components and receipt of screening at 4-month follow-up and reported high acceptability of the program. The pilot study established the feasibility of working with community health advisors to promote colorectal cancer screening in Filipino American community settings. Findings informed the design of a dissemination trial that is currently ongoing with regards to monitoring recruitment, intervention implementation and follow-up and allowing flexibility regarding one-on-one or small group education.

RRDF-98. Russian reactor dosimetry file. Summary documentation

Energy Technology Data Exchange (ETDEWEB)

Pashchenko, A B

1999-03-01

This document summarizes the contents and documentation of the new version of tile Russian Reactor Dosimetry File (RRDF-98) released in December 1998 by the Russian Center on Nuclear Data (CJD) at the Institute of Physics and Power Engineering, Russian Federation. This file contains the original evaluations of cross section data and covariance matrixes for 22 reactions which are used for neutron flux dosimetry by foil activation. The majority of the evaluations included in previous versions of the Russian Reactor Dosimetry Files (BOSPOR-80, RRGF-94 and RRDF-96) have been superseded by new evaluations. The evaluated cross sections of RRDF-98 averaged over 252-Cf and 235-U fission spectra are compared with relevant integral data. The data file is available from the IAEA Nuclear Data Section on diskette, cost free. (author) 9 refs, 22 figs, 2 tabs

[Curcumin alleviates early brain injury following subarachnoid hemorrhage in rats by inhibiting JNK/c-Jun signal pathway].

Science.gov (United States)

Li, Xia; Zhu, Ji

2018-03-01

Objective To investigate the inhibitory effect of curcumin on early brain injury following subarachnoid hemorrhage (SAH) by inhibiting JNK/ c-Jun signal pathway. Methods Sixty adult male SD rats were randomly divided into four groups: sham operation group (sham group), SAH group, SAH group treated with 100 mg/(kg.d) curcumin and SAH group treated with 200 mg/(kg.d) curcumin, with 15 rats in each group. Endovascular puncture was used to induce SAH model. Nissl staining was used to test whether neurons were broken. TUNEL staining was used to detect apoptosis. Immunohistochemistry was used to investigate the expression of caspase-3. Western blot analysis was used to detect the expressions of p-JNK, JNK, p-c-Jun, c-Jun, and caspase-3. Results Nissl staining indicated the decrease of Nissl bodies in SAH group, but increase of Nissl bodies in SAH group treated with curcumin. TUNEL staining showed that there were more apoptotic neurons in SAH group compared with sham group, while apoptotic neurons decreased after the treatment with curcumin, more obviously in the group treated with 200 mg/(kg.d) curcumin. The expressions of p-JNK, JNK, p-c-Jun, c-Jun, and caspase-3 were up-regulated in SAH group compared with sham group. However, the expressions of those proteins were down-regulated after the treatment with curcumin, especially by higher-dose curcumin treatment. Conclusion Curcumin might suppress early brain injury after SAH by inhibiting JNK/c-Jun signal pathway and neuron apoptosis.

Intelligent data retrieval in the industry experience advisor expert system

International Nuclear Information System (INIS)

Swisshelm, J.D.

1991-01-01

ABB Impell Corporation developed a prototype expert system called the Industry Experience Advisor for Florida Power and Light Company. This expert system assists plant engineers in evaluating design changes against previous nuclear industry experience. Previous experience is in the form of root causes or lessons learned of past events. The root-cause statements were developed from an engineering review of important event documents [US Nuclear Regulatory Commission information notices (INs) and information bulletins (IBs) and the Institute of Nuclear Power Operations safety evaluation reports and significant operating experience reports]. This paper describes the project that is currently expanding the prototype into a production system for use at a nuclear plant site. The Industry Experience Advisor should be ready for production release by the end of 1991. It will include knowledge of important events through 1990. In 1992 and in each following year, an update will be released adding the previous year's events

A modular real time Operator Advisor expert system for installation on a full function nuclear power plant simulator

International Nuclear Information System (INIS)

Hajek, B.K.; Miller, D.W.; Bhatnagar, R.; Maresh, J.L.

1989-01-01

A knowledge-based expert system that uses the Generic Task approach is being developed to serve as an operator Advisor in the control room of a commercial nuclear power plant. Having identified the broad scope tasks performed by an operator in responding to abnormal plant conditions, our research team has modularized the Operator Advisor according to the tasks of (1) monitoring plant parameters, (2) classifying or diagnosing the abnormality, and (3) planning for execution of the procedures for recovery. The operator Advisor uses the Perry Nuclear Power Plant full-scope simulator as the reference system, and is currently being prepared for direct connection to the simulator

Regulation of hemeoxygenase-1 gene expression by Nrf2 and c-Jun in tertiary butylhydroquinone-stimulated rat primary astrocytes

International Nuclear Information System (INIS)

Park, Jin-Sun; Kim, Hee-Sun

2014-01-01

Highlights: • tBHQ increased HO-1 mRNA and protein levels in rat primary astrocytes. • tBHQ enhanced HO-1 gene transcription in an ARE-dependent manner. • tBHQ increased the nuclear translocation and DNA binding of Nrf2 and c-Jun to ARE. • Nrf2 and c-Jun are involved in the differential modulation of HO-1 expression. • Nrf2 and c-Jun regulate HO-1 expression via their coordinated interaction. - Abstract: Hemeoxygenase-1 (HO-1) is a phase II antioxidant enzyme that is primarily involved in detoxification and cytoprotection in a variety of tissues. However, the mechanism underlying HO-1 gene expression remains unclear. In the present study, we investigated the regulation of HO-1 expression in primary cultured astrocytes by using the natural antioxidant compound tertiary butylhydroquinone (tBHQ). We found that tBHQ increased HO-1 mRNA and protein levels. Promoter analysis revealed that tBHQ enhanced HO-1 gene transcription in an antioxidant response element (ARE)-dependent manner. In addition, tBHQ increased the nuclear translocation and DNA binding of Nrf2 and c-Jun to ARE. Small interfering RNA (siRNA) experiments demonstrated that Nrf2 and c-Jun are involved in the differential modulation of HO-1 expression. Thus, Nrf2 knockdown reduced the basal level of HO-1 expression but did not affect the fold induction by tBHQ. On the other hand, knockdown of c-Jun diminished tBHQ-mediated induction of HO-1 without affecting basal expression. The data suggest that Nrf2 generally modulates the basal expression of HO-1, while c-Jun mediates HO-1 induction in response to tBHQ. The results of co-immunoprecipitation assays demonstrated a physical interaction between Nrf2 and c-Jun in tBHQ-treated astrocytes. The results suggest that Nrf2 and c-Jun regulate HO-1 expression via their coordinated interaction in tBHQ-treated rat primary astrocytes

The perceived roles and functions of school science subject advisors

African Journals Online (AJOL)

The science subject advisor can play an important role in upgrading ... literature study highlighted practices in the UK and the US that are ... South Africa has recently adopted a strate- ... (North West Province) felt that a solution to their teaching problems ..... teachers, clustering of schools, practical work, cross teaching,.

Risk Management in College Fraternities: Guidance from Two Faculty Advisors

Science.gov (United States)

Rosenberg, Stuart; Mosca, Joseph

2016-01-01

Students who become members of fraternities and sororities avail themselves of significant opportunities that enrich their college life. Faculty advisors play an important role in assisting fraternities and sororities in shaping students' leadership, scholastic, and personal development. Given the risks such as alcohol use and hazing that continue…

Training Mentors as Educational Advisors for Adult Learners. Process Manual.

Science.gov (United States)

Singer, Elizabeth W.

Materials used by the director of a project designed to assist key personnel in businesses, industries, and agencies with the educational counseling of their employees are presented. The objectives of the project, "Training Mentors as Educational Advisors of Adult Learners," were to: (1) provide two training sessions in educational…

The App Squad: SLJ's Advisors Weigh in on Kids' Book Apps

Science.gov (United States)

Ishizuka, Kathy

2011-01-01

In this article, "School Library Journal's" ("SLJ") advisors talk about book apps for kids. They discuss what they like, what one should look for in discerning the best for kids and teens, and where this all might be headed.

β3-adrenergic receptor activation induces TGFβ1 expression in cardiomyocytes via the PKG/JNK/c-Jun pathway.

Science.gov (United States)

Xu, Zhongcheng; Wu, Jimin; Xin, Junzhou; Feng, Yenan; Hu, Guomin; Shen, Jing; Li, Mingzhe; Zhang, Youyi; Xiao, Han; Wang, Li

2018-06-05

In heart failure, the expression of cardiac β 3 -adrenergic receptors (β 3 -ARs) increases. However, the precise role of β 3 -AR signaling within cardiomyocytes remains unclear. Transforming growth factor β1 (TGFβ1) is a crucial cytokine mediating the cardiac remodeling that plays a causal role in the progression of heart failure. Here, we set out to determine the effect of β 3 -AR activation on TGFβ1 expression in rat cardiomyocytes and examine the underlying mechanism. The selective β 3 -AR agonist BRL37344 induced an increase in TGFβ1 expression and the phosphorylation of c-Jun N-terminal kinase (JNK) and c-Jun in β 3 -AR-overexpressing cardiomyocytes. Those effects of BRL37344 were suppressed by a β 3 -AR antagonist. Moreover, the inhibition of JNK and c-Jun activity by a JNK inhibitor and c-Jun siRNA blocked the increase in TGFβ1 expression upon β 3 -AR activation. A protein kinase G (PKG) inhibitor also attenuated β 3 -AR-agonist-induced TGFβ1 expression and the phosphorylation of JNK and c-Jun. In conclusion, the β 3 -AR activation in cardiomyocytes increases the expression of TGFβ1 via the PKG/JNK/c-Jun pathway. These results help us further understand the role of β 3 -AR signaling in heart failure. Copyright © 2018 Elsevier Inc. All rights reserved.

Navigating graduate school and beyond: A career guide for graduate students and a must read for every advisor

Science.gov (United States)

Schultz, Colin

2012-05-01

Beginning his scientific career as an engineering student at PSG College of Technology, in Coimbatore, India, Sundar A. Christopher has negotiated and navigated the higher-education system to become the chairman of the Department of Atmospheric Sciences at the University of Alabama in Huntsville. Drawing on his own experiences and on insights gleaned from the students who have passed through his graduate-level professional development course, Christopher takes a lighthearted look at peer review, proposal writing, managing budgets, and making the most of conferences in the AGU bookNavigating Graduate School and Beyond: A Career Guide for Graduate Students and a Must Read for Every Advisor. In this interview, Eos speaks to Christopher about overcoming the bureaucratic, logistical, and personal hurdles that too often lead students to disillusionment and conflict.

The figure of the helper advisor in cases of sexual abuse against people with intellectual disabilities

Directory of Open Access Journals (Sweden)

Almudena MARTORELL CAFRANGA

2017-09-01

Full Text Available In this paper we analyse the main barriers that people with intellectual disabilities who have suffered sexual abuse have to face when they access the Justice system. Regarding these barriers, the Victim Support Unit for People with Intellectual Disabilities of the Fundación Carmen Pardo-Valcarce proposes the inclusion in the judicial process of a helper advisor. The entry into force in 2015 of the Law 4/2015, in 27 April, the Statute of the crime victim represents an exemplary opportunity to ensure the incorporation of support proposals involving the insertion of the helper advisor in the judicial process in cases where the victim is a person with intellectual disabilities. In this paper we analyse the impact of the helper advisor, with particular emphasis on cases that have been dismissed under instruction.

Demographic Trends and Advocacy Experiences of Gay-Straight Alliance Advisors

Science.gov (United States)

Graybill, Emily C.; Varjas, Kris; Meyers, Joel; Dever, Bridget V.; Greenberg, Daphne; Roach, Andrew T.; Morillas, Catalina

2015-01-01

Using an ecological model, the individual-, school-, and sociocultural-level characteristics that affect gay-straight alliance (GSA) advisors were examined in the current study. The formation of GSAs has been one way that schools have sought to improve the school climate for lesbian, gay, bisexual, and transgender (LGBT) youth. Limited information…

The process of candidates choose graduate programs: an analysis from the advisor perspective; O processo de escolha de candidatos a programas de Pos-Graduacao: uma analise a partir da perspectiva do orientador

Energy Technology Data Exchange (ETDEWEB)

Nascimento, Ridnal Joao do

2016-11-01

This study aims to identify the criteria used by advisors in the decision-making on whether to accept a candidate for mentoring in a postgraduate strictu sensu program and examines possible relationships between this decision and their scientific production and mentees evasion. In order to meet these goals one seeks to identify and analyze the selection criteria of candidates for the master's and doctorate programs at an institution; in this case, the Energy and Nuclear Research Institute - IPEN. More specifically, one seeks to study similarities and differences between those criteria among the advisors; find out whether there is a correlation between the selection criteria and the advisors characteristics (Profile); identify the selection process used by advisors and point out which are the motivations that lead to evasion according to their point of view. To meet these challenges, as the starting point of the research, a conceptual model was designed in order to form the basis for the preparation of the script for the interviews with open-ended questions as to identify the selection criteria used by a small group of advisors with a predefined profile. From that point, based on the responses obtained in interviews, the survey was expanded to all advisors working in the IPEN Postgraduate program by implementing an online survey using Google Docs app for data collection. These data were then analyzed and reorganized according to an operational model of research that would guide the analysis by structural equation modeling (SEM) by means of the SmartPLS software, in order to identify the presence or absence of correlation between the criteria adopted by the advisors and their academic production and the evasion of their mentees, for that one relied on studies in: Bazerman and Moore (2010); Cohen (1988); Hair Jr. et al (2009); Hansmann and Ringle (2004); Martins (1997); Ringle, C.; Silva and Bido (2014); Sousa (2007); Sousa and Yu (2014); Torres (2014); Yu (2011

BDNF restores the expression of Jun and Fos inducible transcription factors in the rat brain following repetitive electroconvulsive seizures.

Science.gov (United States)

Hsieh, T F; Simler, S; Vergnes, M; Gass, P; Marescaux, C; Wiegand, S J; Zimmermann, M; Herdegen, T

1998-01-01

The expression of inducible transcription factors was studied following repetitive electroconvulsive seizures (ECS), c-Fos, c-Jun, JunB, and JunD immunoreactivities were investigated following a single (1 x ECS) or repetitive ECS evoked once per day for 4, 5, or 10 days (4 x ECS, 5 x ECS, or 10 x ECS). Animals were killed 3 or 12 h following the last ECS. Three hours after 1 x ECS, c-Fos was expressed throughout the cortex and hippocampus. After 5 x ECS and 10 x ECS, c-Fos was reexpressed in the CA4 area, but was completely absent in the other hippocampal areas and cortex. In these areas, c-Fos became only reinducible when the time lag between two ECS stimuli was 5 days. In contrast to c-Fos, intense JunB expression was inducible in the cortex and hippocampus, but not CA4 subfield, after 1 x ECS, 5 x ECS, and 10 x ECS. Repetitive ECS did not effect c-Jun and JunD expression. In a second model of systemic excitation of the brain, repetitive daily injection of kainic acid for 4 days completely failed to express c-Fos, c-Jun, and JunB after the last application whereas injection of kainic acid once per week did not alter the strong expressions compared to a single application of kainic acid. In order to study the maintenance of c-Fos expression during repetitive seizures, brain-derived neurotrophic factor (BDNF) was applied in parallel for 5 or 10 days via miniosmotic pumps and permanent cannula targeted at the hippocampus or the parietal cortex. Infusion of BDNF completely reinduced c-Fos expression during 5 x ECS or 10 x ECS in the cortex ipsilaterally to the cannula and, to a less extent, also increased the expression of c-Jun and JunB when compared to saline-treated controls. BDNF had no effect on the expression patterns in the hippocampus. ECS with or without BDNF infusion did not change the expression patterns of the constitutive transcription factors ATF-2, CREB, and SRF. These data demonstrate that various transcription factors substantially differ in their

Heterogeneity in c-jun gene expression in normal and malignant cells exposed to either ionizing radiation or hydrogen peroxide

International Nuclear Information System (INIS)

Horio, M.; Collart, F.R.; Huberman, E.

1993-01-01

We investigated the role of reactive oxygen intermediates and protein kinase C (PKC) in induction of c-jun gene expression in human ML-2 leukemic cells and normal DET-551 fibroblasts by comparing the effects of either ionizing radiation or H 2 O 2 exposure in the presence or absence of appropriate inhibitors. In these cell types, the radiation and H 2 O 2 -mediated increase in c-jun mRNA levels could be prevented by pretreatment of the cells with N-acetylcysteine, an antioxidant, or H7, an inhibitor of PKC and cAMP-dependent protein kinase (PKA), but not by HA1004, an inhibitor of PKA. These results suggest a role for PKC and reactive oxygen intermediates in the induction of c-jun gene expression in both normal and tumor cells. We also investigated potential differences in radiation- or H 2 O 2 -induced c-jun gene expression in normal and tumor cells by examining steady-state c-jun mRNA levels in a number of human fibroblast, leukemia, melanoma, sarcoma, and carcinoma cell types. We observed heterogeneity in the steady-state level of c-jun mRNA in both the untreated normal and tumor cells and in such cells exposed to ionizing radiation or to H 2 O 2 . Exposure to radiation or to hydrogen peroxide produced a varied response which ranged from little or no induction to a more than two orders of magnitude increase in the steady-state level of the c-jun mRNA

Soviet Advisors Group in South China and Soviet Union Financing of Gomindan War Planes in 1924

Directory of Open Access Journals (Sweden)

Александр Геннадьевич Юркевич

2011-12-01

Full Text Available The article dwells on the organization and activities of the Soviet advisors group, which assisted to the South China government of Sun Yatsen, its participation in financing Kuomintang political and military projects. The author pointed out that the main aim of the advisors group efforts was to form new Kuomintang power institutions and to bring its policy and army under control, for all that the tactics of implementation of strategy aim were constantly changing.

Education and training of the shift technical advisor

International Nuclear Information System (INIS)

Thomas, E.L.

1981-01-01

This paper discusses the background and current approaches for qualifying the required position of Shift Technical Advisor (STA). Industry positions regarding the regulation are given. Problems associated with meeting the requirement are identified, along with a discussion of other alternatives for upgrading the education level of shift management. Inherent in the discussion is the conclusion that voluntary improvements in the training and education of shift management personnel are more effective than mandatory positions or degree requirements

Comparative analysis of the tools 'Retrofit Advisor' and 'EPIQR+' - Final report; Analisi comparativa degli strumenti 'Retrofit Advisor' e 'EPIQR+' - Rapporto finale

Energy Technology Data Exchange (ETDEWEB)

Pittet, D.; Ghirlanda, L.

2008-07-01

This report represents the final phase of Swiss Federal Office of Energy project 'Strategy for long-term management of city-owned real estate - the case of the City Council of Chiasso'. It contains a comparative analysis of two tools for the evaluation of the potential for retrofitting and refurbishment of buildings (Retrofit Advisor and Epiqr+). By applying the two tools in parallel, it was possible to compare information and data obtained, and also to obtain indications for the evaluation of the usability of the tools. To achieve this, five buildings in the territory of the city of Chiasso were submitted to the tools for analysis. The applications have highlighted the usability of each case study. The ease of use of Retrofit Advisor has allowed the evaluation of each proposed scenario; by using the same reference system, comparable data are obtained (at indication level) to support the choice of the intervention strategy on existing buildings. In addition to the analysis of the current status, the tool Retrofit Advisor supports a structure analysis over three intervention scenarios, namely reparation, renovation, rebuild. Data entry does not require advanced knowledge of construction work, and is limited to basic characteristics. The analysis performed through Epiqr+ is more rigorous, providing a specific and detailed diagnosis on the state of deterioration of each construction element, supported by a series of intervention suggestions. The Epiqr+ tool has furthermore allowed the evaluation (within a precision range of {+-}15%) the cost of reparation/renovation works, and also the thermal energy balance of each building, based on the characteristics of their envelops. On the basis of contents criteria and cost analysis, the approach has allowed the evaluation of different options for the improvement of the buildings, from simple reparation to total rebuild. Estimates are evaluated in terms of cost, of environmental impact, and, in the case of Retrofit

76 FR 18383 - Extension of Sunset Date for Attorney Advisor Program

Science.gov (United States)

2011-04-04

... Security Online, at http://www.socialsecurity.gov . SUPPLEMENTARY INFORMATION: Electronic Version The... SOCIAL SECURITY ADMINISTRATION 20 CFR Parts 404 and 416 [Docket No. SSA-2009-0048] RIN 0960-AH05 Extension of Sunset Date for Attorney Advisor Program AGENCY: Social Security Administration. ACTION: Final...

77 FR 58593 - Factor Advisors, LLC, et al.; Notice of Application

Science.gov (United States)

2012-09-21

... Factor Advisors (each, an ``Adviser''), and (b) seek investment returns that correspond to the price and... ``ETF,'' an ``investment company,'' a ``fund,'' or a ``trust.'' All marketing materials that describe... SECURITIES AND EXCHANGE COMMISSION [Investment Company Act Release No. 30204; File No. 812-13934...

The CBT Advisor: An Expert System Program for Making Decisions about CBT.

Science.gov (United States)

Kearsley, Greg

1985-01-01

Discusses structure, credibility, and use of the Computer Based Training (CBT) Advisor, an expert system designed to help managers make judgements about course selection, system selection, cost/benefits, development effort, and probable success of CBT projects. (MBR)

Ties That Bind: Academic Advisors as Agents of Student Relationship Management

Science.gov (United States)

Vianden, Jörg

2016-01-01

To affect college retention, academic advisors should act as agents of student relationship management by strengthening the connection between students and their institutions. Satisfaction and dissatisfaction with academic advising as perceived by 29 college students at 3 midwestern comprehensive institutions are described. Discussion is framed in…

75 FR 33857 - DWS Advisor Funds, et al.; Notice of Application

Science.gov (United States)

2010-06-15

...''). Applicants state that the DWS Funds of Funds will offer investors a range of investment objectives generally... investment objectives and policies of the Unaffiliated Fund; (b) how the performance of securities purchased... Advisor Funds, et al.; Notice of Application June 9, 2010. AGENCY: Securities and Exchange Commission...

Moessbauer study of the firing technology of the moon-white Jun porcelain in Chinese Yuan Dynasty

International Nuclear Information System (INIS)

Chen Songhua

1994-01-01

The moon-white Jun porcelain glaze contains Fe 2 O 3 , Fe 3 O 4 and structural iron. The firing atmosphere of ancient Jun kilns was modestly reductive. The firing temperature was slightly above 1250 C. The glaze color appears moon-white, and is related to the low concentration of Fe 2+ . The coordination numbers of Fe 2+ and Fe 3+ are both 4. (orig.)

Application of Chinese Jun-Cao technique for the production of Brazilian Ganoderma lucidum strains

Directory of Open Access Journals (Sweden)

Leonardo do Nascimento Rolim

2014-06-01

Full Text Available Ganoderma lucidum is a medicinal mushroom traditionally used in China against a wide range of diseases such as cancer and also for its prevention. In this work, commercial Chinese strains G. lucidum were compared to wild Brazilian strains aiming to determine the cultivation potential through the use of Jun-Cao. Six formulations were tested and the strains presented good response to the applied method. In general, the mixture between the grass and wood was well suited for the basidiomycetes, contributing to the preparation of substrates that generated better results in Jun Cao.

Adsorption kinetics of c-Fos and c-Jun to air-water interfaces.

Science.gov (United States)

Del Boca, Maximiliano; Nobre, Thatyane Morimoto; Zaniquelli, Maria Elisabete Darbello; Maggio, Bruno; Borioli, Graciela A

2007-11-01

The kinetics of adsorption to air-water interfaces of the biomembrane active transcription factors c-Fos, c-Jun and their mixtures is investigated. The adsorption process shows three distinct stages: a lag time, a fast pseudo zero-order stage, and a halting stage. The initial stage determines the course of the process, which is concentration dependent until the end of the fast stage. We show that c-Fos has faster adsorption kinetics than c-Jun over all three stages and that the interaction between both proteins is apparent in the adsorption profiles of the mixtures. Protein molecular reorganization at the interface determines the transition to the final adsorption stage of the pure proteins as well as that of the mixtures.

Methodological quality and scientific impact of quantitative nursing education research over 18 months.

Science.gov (United States)

Yucha, Carolyn B; Schneider, Barbara St Pierre; Smyer, Tish; Kowalski, Susan; Stowers, Eva

2011-01-01

The methodological quality of nursing education research has not been rigorously studied. The purpose of this study was to evaluate the methodological quality and scientific impact of nursing education research reports. The methodological quality of 133 quantitative nursing education research articles published between July 2006 and December 2007 was evaluated using the Medical Education Research Study Quality Instrument (MERSQI).The mean (+/- SD) MERSQI score was 9.8 +/- 2.2. It correlated (p nursing literature and those reported for the medical literature, coupled with the association with citation counts, suggest that the MERSQI is an appropriate instrument to evaluate the quality of nursing education research.

76 FR 70779 - President's Council of Advisors on Science and Technology

Science.gov (United States)

2011-11-15

... University of Michigan North Campus Research Complex, 2800 Plymouth Road, Building 18, Ann Arbor, MI 48109... the University of Michigan North Research Complex from 8:30 a.m. to 2:45 p.m. on December 12, 2011... OFFICE OF SCIENCE AND TECHNOLOGY POLICY President's Council of Advisors on Science and Technology...

77 FR 10736 - President's Council of Advisors on Science and Technology (PCAST)

Science.gov (United States)

2012-02-23

... an overview of the Department of Agriculture's science, technology, and innovation activities, and... DEPARTMENT OF ENERGY President's Council of Advisors on Science and Technology (PCAST) AGENCY... Science and Technology (PCAST), and describes the functions of the Council. Notice of this meeting is...

Androgen receptor requires JunD as a coactivator to switch on an oxidative stress generation pathway in prostate cancer cells.

Science.gov (United States)

Mehraein-Ghomi, Farideh; Basu, Hirak S; Church, Dawn R; Hoffmann, F Michael; Wilding, George

2010-06-01

Relatively high oxidative stress levels in the prostate are postulated to be a major factor for prostate carcinogenesis and prostate cancer (CaP) progression. We focused on elucidating metabolic pathways of oxidative stress generation in CaP cells. Previously, we showed that the transcription factor JunD is essential for androgen-induced reactive oxygen species (ROS) production in androgen-dependent human CaP cells. We also recently showed that androgen induces the first and regulatory enzyme spermidine/spermine N1-acetyltransferase (SSAT) in a polyamine catabolic pathway that produces copious amounts of metabolic ROS. Here, we present coimmunoprecipitation and Gaussia luciferase reconstitution assay data that show that JunD forms a complex with androgen-activated androgen receptor (AR) in situ. Our chromatin immunoprecipitation assay data show that JunD binds directly to a specific SSAT promoter sequence only in androgen-treated LNCaP cells. Using a vector containing a luciferase reporter gene connected to the SSAT promoter and a JunD-silenced LNCaP cell line, we show that JunD is essential for androgen-induced SSAT gene expression. The elucidation of JunD-AR complex inducing SSAT expression leading to polyamine oxidation establishes the mechanistic basis of androgen-induced ROS production in CaP cells and opens up a new prostate-specific target for CaP chemopreventive/chemotherapeutic drug development. Copyright 2010 AACR.

The treatment implementation advisor: a component of the GypsES project

Science.gov (United States)

Michael C. Saunders; Michael A. Foster

1991-01-01

The treatment implementation advisor is one of the knowledge based advisory modules of GypsES, a knowledge system environment for decision support in gypsy moth management. Its function is to provide detailed advice on intervention tactics for gypsy moth: e.g. aerial and ground application of insecticides and microbials, inundative or augmentative releases of...

A Pervasive Social Networking Application: I-NFC enabled Florist Smart Advisor

Science.gov (United States)

Swee Wen, Khoo; Mahinderjit Singh, Manmeet

2016-11-01

Location based service is an information and entertainment service, accessible with mobile devices through the mobile network and utilizing the ability to make use of the geographical position of the mobile device. NFC location based service is using one of the modes of NFC such as peer-to-peer, reader/writer, and card emulation to obtain the information of the object and then get the location of the object. In this paper, the proposed solution is I- NFC-enabled Pervasive Social Networking apps for florists. It combines the NFC location based service with Online Social Network (OSN). In addition, a smart advisor in the system to provide output in making their own decision while purchasing products.The development of the system demonstrates that a designed commerce site is provided which enable a communication between NFC-enabled smartphone, NFC-enabled application and OSN. GPS functionalities also implemented to provide map and location of business services. Smart advisor also designed to provide information for users who do not have ideas what to purchase.

Mössbauer study of the firing technology of the moon-white Jun porcelain in Chinese Yuan Dynasty

Science.gov (United States)

Songhua, Chen; Zhengyao, Gao; Zhongtian, Sun; Xiande, Chen

1994-12-01

The moon-white Jun porcelain glaze contains Fe2O3, Fe3O4 and structural iron. The firing atmosphere of ancient Jun kilns was modestly reductive. The firing temperature was slightly above 1250 ‡C. The glaze color appears moon-white, and is related to the low concentration of Fe2+. The coordination numbers of Fe2+ and Fe3+ are both 4.

77 FR 65593 - PNC Capital Advisors, LLC, et al.; Notice of Application

Science.gov (United States)

2012-10-29

... registered open-end management investment companies that operate as ``funds of funds'' to acquire shares of.... Applicants: PNC Capital Advisors, LLC (``Adviser'') and PNC Funds and PNC Advantage Funds (each a ``Trust... statutory trust. Each Trust is comprised of separate series that pursue distinct investment objectives and...

Spot and Runway Departure Advisor (SARDA)

Science.gov (United States)

Jung, Yoon

2016-01-01

Spot and Runway Departure Advisor (SARDA) is a decision support tool to assist airline ramp controllers and ATC tower controllers to manage traffic on the airport surface to significantly improve efficiency and predictability in surface operations. The core function of the tool is the runway scheduler which generates an optimal solution for runway sequence and schedule of departure aircraft, which would minimize system delay and maximize runway throughput. The presentation also discusses the latest status of NASA's current surface research through a collaboration with an airline partner, where a tool is developed for airline ramp operators to assist departure pushback operations. The presentation describes the concept of the SARDA tool and results from human-in-the-loop simulations conducted in 2012 for Dallas-Ft. Worth International Airport and 2014 for Charlotte airport ramp tower.

Alterações da junção neuromuscular em miopatias experimentais no camundongo

Directory of Open Access Journals (Sweden)

Luiz Fernando Bleggi Torres

1989-06-01

Full Text Available As alterações morfológicas observadas em junção neuromuscular de dois modelos de miopatia em camundongos são estudadas por métodos histoquímicos para demonstrar atividade da enzima acetilcolinesterase e por microscopia eletrônica. Em ambas as situações os resultados obtidos são similares, indicando que a junção neuromuscular permanece intacta mesmo quando a fibra que inerva está sofrendo necrose. Em fibras musculares regeneradas há acentuada simplificação das pregas pós-sinápticas, com redução de até 50% dos valores normais, comprovado por estudos morfométricos. A ausência de repercussões fisiológicas ou clínicas detectáveis nesses modelos, apesar da significativa hipotrofia da membrana pós-sináptica, sugere que a exuberante quantidade de pregas pós-sinápticas normalmente encontradas nas junções mioneürais pode representar mecanismo anatômico de segurança na transmissão química neuromuscular.

MAGE-A1 promotes melanoma proliferation and migration through C-JUN activation

Energy Technology Data Exchange (ETDEWEB)

Wang, Dong [Department of Dermatology, General Hospital of People' s Liberation Army, Beijing 100853 (China); The 309th Hospital of China People' s Liberation Army, Beijing 100091 (China); Wang, Junyun; Ding, Nan [CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Li, Yongjun; Yang, Yaran [CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101 (China); Fang, Xiangdong, E-mail: fangxd@big.ac.cn [CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101 (China); Zhao, Hua, E-mail: luckhua301@163.com [Department of Dermatology, General Hospital of People' s Liberation Army, Beijing 100853 (China)

2016-05-13

MAGE-A1 belongs to the chromosome X-clustered genes of cancer-testis antigen family and is normally expressed in the human germ line but is also overexpressed in various tumors. Previous studies of MAGE-A1 in melanoma mainly focused on methylation changes or its role in immunotherapy, however, its biological functions in melanoma have remained unknown. In order to determine the role of MAGE-A1 in melanoma growth and metastasis, we manipulated melanoma cell lines with overexpression and knockdown of MAGE-A1. Integration of cell proliferation assays, transwell migration and invasion assays, and RNA-Seq analysis revealed that up-regulation of MAGE-A1 dramatically promoted proliferation, migration, and invasion of human melanoma cell lines in vitro, while down-regulation of MAGE-A1 inhibited those characteristics associated with tumor cells. Furthermore, transcriptome sequencing revealed that MAGE-A1 exerts its tumor promoting activity by activating p-C-JUN directly or through ERK-MAPK signaling pathways. Based on our findings, we propose that MAGE-A1 may be a potential therapeutic target for melanoma patients. - Highlights: • MAGE-A1 promotes proliferation and clone formation in melanoma cell lines. • MAGE-A1 enhances tumor cell migration and invasion in melanoma cell lines. • Network including C-JUN, IL8, and ARHGAP29 play critical role in malignant melanoma. • Oncogenic MAGE-A1 increases p-C-JUN levels, possibly via ERK-MAPK signaling pathway.

Spot and Runway Departure Advisor

Science.gov (United States)

Jung, Yoon Chul

2013-01-01

The Spot and Runway Departure Advisor (SARDA) is a research prototype of a decision support tool for ATC tower controllers to assist in manging and controlling traffic on the surface of an airport. SARDA employs a scheduler to generate an optimal runway schedule and gate push-back - spot release sequence and schedule that improves efficiency of surface operations. The advisories for ATC tower controllers are displayed on an Electronic Flight Strip (EFS) system. The human-in-the-loop simulation of the SARDA tool was conducted for east operations of Dallas-Ft. Worth International Airport (DFW) to evaluate performance of the SARDA tool and human factors, such as situational awareness and workload. The results indicates noticeable taxi delay reduction and fuel savings by using the SARDA tool. Reduction in controller workload were also observed throughout the scenario runs. The future plan includes modeling and simulation of the ramp operations of the Charlotte International Airport, and develop a decision support tool for the ramp controllers.

Moessbauer study of the firing process of the imitative ancient sky-blue Jun porcelain

International Nuclear Information System (INIS)

Gao Zhengyao; Chen Xiande

1994-01-01

Moessbauer spectra of the imitative ancient Jun porcelain indicate that the glaze and body materials contain Fe 2 O 3 , Fe 3 O 4 and structural iron. It is clear that during the firing process, the glaze undergoes dehydration, dehydroxylation, vitrification and recrystallization. The Fe 2+ quadrupole splitting value of the paramagnetic peak of the body material is high even at low firing temperatures. For the body material, the distinction between dehydration and dehydroxylation is not clear. The changes of magnetism of the glaze and body materials in the firing process and the coloring mechanism of the sky-blue Jun porcelain are analyzed in the present paper. (orig.)

Graduate Students' Perceptions of Their Advisors: Is There Systematic Disadvantage in Mentorship?

Science.gov (United States)

Noy, Shiri; Ray, Rashawn

2012-01-01

We explore how race and gender shape graduate students' perceptions of their advisors. We find evidence that women of color and students in the biological/physical sciences report significantly less support than other groups. Our findings speak to the utility of the intersectionality framework for examining interpersonal relations in higher…

Exploring Inner Speech as a Psycho-Educational Resource for Language Learning Advisors

Science.gov (United States)

McCarthy, Tanya M.

2018-01-01

The analysis of advising sessions has recognized common standards of the profession in areas such as advising skills employed and non-verbal communicative practices. There are however numerous variations in advisor behavior due to differences in cognitive processes. This study used a stimulated recall approach to identify the content of inner…

Aspects Fostering the Programming of Today's College Radio Station: The Advisor's Perspective.

Science.gov (United States)

Sauls, Samuel J.

To help ascertain leadership, guidance, and capabilities of the station advisor (those who foster the efforts of their student staffs), this paper provides an overview of programming elements discussing such topics as programming philosophy, general formats, and legal and ethical issues. It states that those advising the campus radio station can…

Marcadores fenotípicos de atenuación en cepas de virus Junín recuperadas de individuos vacunados con la cepa Junín Candid#1

Directory of Open Access Journals (Sweden)

Graciela S. Gamboa

2013-08-01

Full Text Available La Fiebre Hemorrágica Argentina es una enfermedad producida por el virus Junín. Para la prevención de esta enfermedad se obtuvo una vacuna efectiva denominada Candid#1. Durante un ensayo clínico realizado en el INEVH, dos cepas de virus Junín fueron aisladas de sangre periférica de dos voluntarios mediante co-cultivo de células mononucleares. El objetivo de este trabajo fue comparar las características fenotípicas de atenuación de esas dos cepas recuperadas de humanos con las de la vacuna Candid#1 utilizando los indicadores de atenuación desarrollados por Contigiani y Sabattini en 1977. A tal fin se midieron los índices de letalidad, infección y protección en cobayos y ratones de diferentes edades. Las tres cepas investigadas resultaron letales para ratones recién nacidos pero no para ratones de 10 a 12 días, ratones adultos ni cobayos, aun a la más baja dilución inoculada. Los cobayos inoculados con las cepas recuperadas de humanos y con la cepa Candid#1 no presentaron síntomas de enfermedad y mostraron estar protegidos cuando fueron desafiados con una cepa patógena. Los índices de infección y de protección hallados indican que estas cepas poseen elevada capacidad infectante y protectora en las especies animales aquí estudiadas. Estos resultados demuestran que las cepas de virus Junín aisladas de voluntarios inmunizados con Candid#1 mantienen el mismo fenotipo atenuado de la vacuna Candid#1 después de un pasaje por humanos.

STS-98 U.S. Lab Destiny rests in Atlantis' payload bay

Science.gov (United States)

2001-01-01

KENNEDY SPACE CENTER, Fla. -- The U.S. Lab Destiny rests in the payload bay of Space Shuttle Atlantis. A key element in the construction of the International Space Station, Destiny is 28 feet long and weighs 16 tons. This research and command-and-control center is the most sophisticated and versatile space laboratory ever built. It will ultimately house a total of 23 experiment racks for crew support and scientific research. Destiny will fly on STS-98, the seventh construction flight to the ISS. Launch of STS-98 is scheduled for Jan. 19 at 2:11 a.m. EST.

Induction of c-Jun by air particulate matter (PM₁₀) of Mexico city: Participation of polycyclic aromatic hydrocarbons.

Science.gov (United States)

Salcido-Neyoy, Martha Estela; Sánchez-Pérez, Yesennia; Osornio-Vargas, Alvaro Román; Gonsebatt, María Eugenia; Meléndez-Zajgla, Jorge; Morales-Bárcenas, Rocío; Petrosyan, Pavel; Molina-Servin, Edith Danny; Vega, Elizabeth; Manzano-León, Natalia; García-Cuellar, Claudia M

2015-08-01

The carcinogenic potential of urban particulate matter (PM) has been partly attributed to polycyclic aromatic hydrocarbons (PAHs) content, which activates the aryl hydrocarbon receptor (AhR). Here we report the effect of PM with an aerodynamic size of 10 μm (PM10) on the induction of AhR pathway in A549 cells, evaluating its downstream targets CYP1B1, IL-6, IL-8 and c-Jun. Significant increases in CYP1B1 protein and enzyme activity; IL-6 and IL-8 secretion and c-Jun protein were found in response to PM10. The formation of PAH-DNA adducts was also detected. The involvement of AhR pathway was confirmed with Resveratrol as AhR antagonist, which reversed CYP1B1 and c-Jun induction. Nevertheless, in IL-6 and IL-8 secretion, the Resveratrol was ineffective, suggesting an effect independent of this pathway. Considering the role of c-Jun in oncogenesis, its induction by PM may be contributing to its carcinogenic potential through induction of AhR pathway by PAHs present in PM10. Copyright © 2015 Elsevier Ltd. All rights reserved.

Prostaglandin E2 stimulates normal bronchial epithelial cell growth through induction of c-Jun and PDK1, a kinase implicated in oncogenesis.

Science.gov (United States)

Fan, Yu; Wang, Ye; Wang, Ke

2015-12-18

Cyclooxygenase-2-derived prostaglandin E2 (PGE2), a bioactive eicosanoid, has been implicated in many biological processes including reproduction, inflammation and tumor growth. We previously showed that PGE2 stimulated lung cancer cell growth and progression through PGE2 receptor EP2/EP4-mediated kinase signaling pathways. However, the role of PGE2 in controlling lung airway epithelial cell phenotype remains unknown. We evaluated the effects of c-Jun and 3-phosphoinositede dependent protein kinase-1 (PDK1) in mediating epithelial cell hyperplasia induced by PGE2. The bronchial epithelial cell lines BEAS-2B and HBEc14-KT were cultured and then treated with PGE2. PDK1 small interfering RNA (siRNA) and a PDK1 inhibitor, an antagonist of the PGE2 receptor subtype EP4 and EP4 siRNA, c-Jun siRNA, and overexpressions of c-Jun and PDK1 have been used to evaluate the effects on cell proliferation. We demonstrated that PGE2 increased normal bronchial epithelial cell proliferation through induction of PDK1, an ankyrin repeat-containing Ser/Thr kinase implicated in the induction of apoptosis and the suppression of tumor growth. PDK1 siRNA and a PDK1 inhibitor blocked the effects of PGE2 on normal cell growth. The PGE2-induced PDK1 expression was blocked by an antagonist of the PGE2 receptor subtype EP4 and by EP4 siRNA. In addition, we showed that induction of PDK1 by PGE2 was associated with induction of the transcription factor, c-Jun protein. Silencing of c-Jun using siRNA and point mutations of c-Jun sites in the PDK1 gene promoter resulted in blockade of PDK1 expression and promoter activity induced by PGE2. In contrast, overexpression of c-Jun induced PDK1 gene promoter activity and expression followed increased cell proliferation. PGE2 increases normal bronchial epithelial cell proliferation through increased PDK1 gene expression that is dependent on EP4 and induction of c-Jun. Therewith, our data suggest a new role of c-Jun and PDK1 in mediating epithelial cell

40 CFR 35.4190 - How does my group identify a qualified technical advisor?

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false How does my group identify a qualified technical advisor? 35.4190 Section 35.4190 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS...: (1) Demonstrated knowledge of hazardous or toxic waste issues, relocation issues, redevelopment...

Roofline Analysis in the Intel® Advisor to Deliver Optimized Performance for applications on Intel® Xeon Phi™ Processor

OpenAIRE

Koskela, TS; Lobet, M

2017-01-01

In this session we show, in two case studies, how the roofline feature of Intel Advisor has been utilized to optimize the performance of kernels of the XGC1 and PICSAR codes in preparation for Intel Knights Landing architecture. The impact of the implemented optimizations and the benefits of using the automatic roofline feature of Intel Advisor to study performance of large applications will be presented. This demonstrates an effective optimization strategy that has enabled these science appl...

Radiation-induced apoptosis in developing rats and kainic acid-induced excitotoxicity in adult rats are associated with distinctive morphological and biochemical c-Jun/AP-1 (N) expression

Energy Technology Data Exchange (ETDEWEB)

Pozas, E. [Unitat de Neuropatologia, Servei d' Anatomia Patologica, Hospital Princeps d' Espanya, Universitat de Barcelona, 08907 Hospitalet de Llobregat (Spain); Planas, A.M. [Departament de Farmacologia i Toxicologia, IIBB, CSIC Barcelona (Spain); Ferrer, I. [Unitat de Neuropatologia, Servei d' Anatomia Patologica, Hospital Princeps d' Espanya, Universitat de Barcelona, 08907 Hospitalet de Llobregat (Spain)

1997-07-14

Ionizing radiation produces apoptosis in the developing rat brain. Strong c-Jun immunoreactivity, as revealed with the antibody c-Jun/AP-1 (N) which is raised against the amino acids 91-105 mapping with the amino terminal domain of mouse c-Jun p39, is simultaneously observed in the nucleus and cytoplasm of apoptotic cells. Western blotting of total brain homogenates, using the same antibody, shows a p39 band in control rats which is accompanied by a strong, phosphorylated p62 double-band in irradiated animals. In addition, increased c-Jun N-terminal kinase 1 expression, as found on western blots, is found in irradiated rats when compared with controls. Intraperitoneal injection of kainic acid at convulsant doses to the adult rat produces cell death with morphological features of necrosis, together with the appearance of cells with fine granular chromatin degeneration and small numbers of apoptotic-like cells, in the entorhinal and piriform cortices, basal amygdala, certain thalamic nuclei, and CA1 region of the hippocampus. c-Jun expression in kainic acid-treated rats, as revealed with the c-Jun/AP-1 (N) antibody, is found in the nuclei of a minority of cells in the same areas. The vast majority of c-Jun-immunoreactive cells have normal nuclear morphology, whereas necrotic cells are negative and only a few cells with fine granular chromatin condensation and apoptotic cells following kainic acid injection are stained with c-Jun antibodies. Western blotting, using the same antibody, shows a p39 band in control rats, which is accompanied by a band at about p26 from 6 h onwards following kainic acid injection. Decreased c-Jun N-terminal kinase 1 expression, as revealed on western blots, is observed in kainic acid-treated rats.These results show that the antibody c-Jun/AP-1 (N) recognizes three different forms of c-Jun-related immunoreactivity in normal and pathological states, which are associated with the different outcome of cells. These results stress the necessity

Virtue and Responsibility in Policy Research and Advice

NARCIS (Netherlands)

Tholen, J.H.M.M.

2017-01-01

This book argues that ethical judgment by individual scientific policy advisors is more important than is often acknowledged. While many scientific policy advisors routinely present themselves as neutral or value free scientists, here is demonstrated that the ideal of scientific integrity as

Contribuciones hacia la cronología del Periodo Arcaico en las punas de Junín

OpenAIRE

Kaulicke, Peter

2012-01-01

Some Contributions to the Chronology of the Archaic Period in the Punas of JunínThe stratigraphy and the typology from the Uchkumachay excavations are presented as well as preliminary results of a comparative study undertaken in collaboration with D. Lavallée and M. Julien. These data bear major importance on the building of a general chronology and synthesis of the Archaic Period which still is missing for the Junín area in spite of being one of the best studied areas in the Central Andes fo...

Peptide-DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun.

Science.gov (United States)

Pazos, Elena; Portela, Cecilia; Penas, Cristina; Vázquez, M Eugenio; Mascareñas, José L

2015-05-21

We describe a ds-oligonucleotide-peptide conjugate that is able to efficiently dismount preformed DNA complexes of the bZIP regions of oncoproteins c-Fos and c-Jun (AP-1), and therefore might be useful as disrupters of AP-1-mediated gene expression pathways.

C-Jun N-terminal kinase signalling pathway in response to cisplatin.

Science.gov (United States)

Yan, Dong; An, GuangYu; Kuo, Macus Tien

2016-11-01

Cisplatin (cis diamminedichloroplatinum II, cDDP) is one of the most effective cancer chemotherapeutic agents and is used in the treatment of many types of human malignancies. However, inherent tumour resistance is a major barrier to effective cisplatin therapy. So far, the mechanism of cDDP resistance has not been well defined. In general, cisplatin is considered to be a cytotoxic drug, for damaging DNA and inhibiting DNA synthesis, resulting in apoptosis via the mitochondrial death pathway or plasma membrane disruption. cDDP-induced DNA damage triggers signalling pathways that will eventually decide between cell life and death. As a member of the mitogen-activated protein kinases family, c-Jun N-terminal kinase (JNK) is a signalling pathway in response to extracellular stimuli, especially drug treatment, to modify the activity of numerous proteins locating in the mitochondria or the nucleus. Recent studies suggest that JNK signalling pathway plays a major role in deciding the fate of the cell and inducing resistance to cDDP-induced apoptosis in human tumours. c-Jun N-terminal kinase regulates several important cellular functions including cell proliferation, differentiation, survival and apoptosis while activating and inhibiting substrates for phosphorylation transcription factors (c-Jun, ATF2: Activating transcription factor 2, p53 and so on), which subsequently induce pro-apoptosis and pro-survival factors expression. Therefore, it is suggested that JNK signal pathway is a double-edged sword in cDDP treatment, simultaneously being a significant pro-apoptosis factor but also being associated with increased resistance to cisplatin-based chemotherapy. This review focuses on current knowledge concerning the role of JNK in cell response to cDDP, as well as their role in cisplatin resistance. © 2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

Architects, Captains, and Dreamers: Creating Advisor Roles that Foster Youth-Adult Partnerships

Science.gov (United States)

Mitra, Dana; Lewis, Tiffanie; Sanders, Felicia

2013-01-01

While research has documented the many ways in which student voice can enable educational change, the process of how adults can help to enable student voice is less clear. This article examines how adults new to working as advisors of student voice initiatives begin to develop partnerships with young people. Using a Youth-Adult Partnership…

Analysis of elemental maps from glaze to body of ancient Chinese Jun and Ru porcelain by micro-X-ray fluorescence

Energy Technology Data Exchange (ETDEWEB)

Cheng Lin [Key Laboratory of Beam Technology and Material Modification of Ministry of Education, College of Nuclear Science and Technology, Beijing Normal University, Beijing Radiation Center, Beijing 100875 (China)], E-mail: chenglin@bnu.edu.cn; Li Rongwu [Department of Physics, Beijing Normal University, Beijing 100049 (China); Pan Qiuli [Key Laboratory of Beam Technology and Material Modification of Ministry of Education, College of Nuclear Science and Technology, Beijing Normal University, Beijing Radiation Center, Beijing 100875 (China); Li Guoxia; Zhao Weijuan [Institute of Physical Engineering, Zhengzhou University, Zhengzhou 450052 (China); Liu Zhiguo [Key Laboratory of Beam Technology and Material Modification of Ministry of Education, College of Nuclear Science and Technology, Beijing Normal University, Beijing Radiation Center, Beijing 100875 (China)

2009-01-15

The reasons how the middle layer of Ru and Jun porcelain between the glaze and body came into being are still not completely understood. Here, elemental maps from the glaze to the body of pieces of ancient Chinese Ru and Jun porcelain were analyzed by micro-X-ray fluorescence. The results show the middle layer was probably formed by the chemical composition of the glaze turning into glassy states and undergoing complex physical-chemical reactions with the body. However, the middle layer of Jun porcelain was formed by the chemical composition of the glaze turning into glassy states and then infiltrating the body at high temperatures during the firing process.

Analysis of elemental maps from glaze to body of ancient Chinese Jun and Ru porcelain by micro-X-ray fluorescence

Science.gov (United States)

Cheng, Lin; Li, Rongwu; Pan, Qiuli; Li, Guoxia; Zhao, Weijuan; Liu, Zhiguo

2009-01-01

The reasons how the middle layer of Ru and Jun porcelain between the glaze and body came into being are still not completely understood. Here, elemental maps from the glaze to the body of pieces of ancient Chinese Ru and Jun porcelain were analyzed by micro-X-ray fluorescence. The results show the middle layer was probably formed by the chemical composition of the glaze turning into glassy states and undergoing complex physical-chemical reactions with the body. However, the middle layer of Jun porcelain was formed by the chemical composition of the glaze turning into glassy states and then infiltrating the body at high temperatures during the firing process.

Identification of ASK1, MKK4, JNK, c-Jun, and caspase-3 as a signaling cascade involved in cadmium-induced neuronal cell apoptosis

International Nuclear Information System (INIS)

Kim, Sun Don; Moon, Chang Kyu; Eun, Su-Yong; Ryu, Pan Dong; Jo, Sangmee Ahn

2005-01-01

Cd induces oxidative stress and apoptosis in various cells by activating mitogen-activated protein kinases (MAPKs), but the precise signaling components of the MAPK cascade and their role in neuronal apoptosis are still unclear. Here, we report that Cd treatment of SH-SY5Y cells caused apoptosis through sequential phosphorylation of the apoptosis signal regulating kinase 1, MAPK kinase 4, c-Jun N-terminal kinase (JNK), and c-Jun as determined by overexpression of dominant negative (DN) constructs of these genes or using a specific JNK inhibitor SP600125. Both Cd-induced JNK and c-Jun phosphorylation and apoptosis were inhibited dramatically by N-acetyl-L-cysteine, a free radical scavenger. In addition, caspase inhibitors, zDEVD and zVAD, reduced apoptosis but not JNK and c-Jun phosphorylation induced by Cd, while overexpression of DN JNK1 inhibited caspase-3 activity. Taken together, our data suggested that the JNK/c-Jun signaling cascade plays a crucial role in Cd-induced neuronal cell apoptosis and provides a molecular linkage between oxidative stress and neuronal apoptosis

Expression of c-fos and c-jun proteins in the marginal division of the rat striatum during learning and memory training

Institute of Scientific and Technical Information of China (English)

BAO Xin-min; SHU Si-yun; WANG Hong

2005-01-01

Background A new brain region, the marginal division (MrD), was discovered at the caudal margin of the neostriatum. The MrD was shown to be involved in learning and memory in the rat. The aim of this study was to investigate the expression of the immediate-early genes c-fos and c-jun in the MrD of the striatum during learning and memory processes in the rat, immunocytochemical and Western blot methods were used to examine Y-maze trained rats.Methods The rats were divided into three groups, namely the training, pseudotraining, and control groups. After Y-maze training, the expression of the immediate-early genes c-fos and c-jun in the MrD of the rats was investigated using immunocytochemical and Western blot methods. Results After one hour of Y-maze training, the expression of c-jun and c-fos proteins was significantly enhanced in the MrD; the c-jun protein, in particular, was more intensely expressed in this region than in other parts of the striatum. The expression of these two proteins in the training group was significantly higher than in the pseudotraining and control groups. In addition, positive expression was also found in the hippocampus, cingulum cortex, thalamus, and in other areas. Western blot disclosed two immunoreactive bands for the anti-c-fos antibody (47 kD and 54 kD) and two immunoreactive bands for the anti-c-jun antibody (39 kD and 54 kD). Conclusions These results indicate that the immediate-early genes c-fos and c-jun participate in signal transduction during the learning and memory processes associated with Y-maze training in rats.

Functional cooperation between HIF-1α and c-Jun in mediating primary and acquired resistance to gefitinib in NSCLC cells with activating mutation of EGFR.

Science.gov (United States)

Meng, Shuyan; Wang, Guorui; Lu, Yang; Fan, Zhen

2018-07-01

Hypoxia-inducible factor 1 (HIF-1) and activator protein 1 (AP-1) are important transcription factors regulating expression of genes involved in cell survival. HIF-1α and c-Jun are key components of HIF-1 and AP-1, respectively, and are regulated by epidermal growth factor receptor (EGFR)-mediated cell signaling and tumor microenvironmental cues. The roles of HIF-1α and c-Jun in development of resistance to EGFR tyrosine kinase inhibitor (TKI) in non-small cell lung cancer (NSCLC) with activating mutation of EGFR have not been explored. In this study, we investigated the roles of HIF-1α and c-Jun in mediating primary and acquired resistance to gefitinib in NSCLC cells with activating mutation of EGFR. Changes in HIF-1α protein and in total and phosphorylated c-Jun levels in relation to changes in total and phosphorylated EGFR levels before and after gefitinib treatment were measured using Western blot analysis in NSCLC cells sensitive or resistant to gefitinib. The impact of overexpression of a constitutively expressed HIF-1α (HIF-1α/ΔODD) or a constitutively active c-Jun upstream regulator (SEK1 S220E/T224D mutant) on cell response to gefitinib was also examined. The effect of pharmacological inhibition of SEK1-JNK-c-Jun pathway on cell response to gefitinib was evaluated. Downregulation of HIF-1α and total and phosphorylated c-Jun levels correlated with cell inhibitory response to gefitinib better than decrease in phosphorylated EGFR did in NSCLC cells with intrinsic or acquired resistance to gefitinib. Overexpression of HIF-1α/ΔODD or SEK1 S220E/T224D mutant conferred resistance to gefitinib. There exists a positive feed-forward regulation loop between HIF-1 and c-Jun. The JNK inhibitor SP600125 sensitized gefitinib-resistant NSCLC cells to gefitinib. HIF-1α and c-Jun functionally cooperate in development of resistance to gefitinib in NSCLC cells. The translational value of inhibiting HIF-1α/c-Jun cooperation in overcoming resistance to EGFR TKI

RRDF-98. Russian reactor dosimetry file. Summary documentation

International Nuclear Information System (INIS)

Pashchenko, A.B.

1999-01-01

This document summarizes the contents and documentation of the new version of tile Russian Reactor Dosimetry File (RRDF-98) released in December 1998 by the Russian Center on Nuclear Data (CJD) at the Institute of Physics and Power Engineering, Russian Federation. This file contains the original evaluations of cross section data and covariance matrixes for 22 reactions which are used for neutron flux dosimetry by foil activation. The majority of the evaluations included in previous versions of the Russian Reactor Dosimetry Files (BOSPOR-80, RRGF-94 and RRDF-96) have been superseded by new evaluations. The evaluated cross sections of RRDF-98 averaged over 252-Cf and 235-U fission spectra are compared with relevant integral data. The data file is available from the IAEA Nuclear Data Section on diskette, cost free. (author)

Possible reasons why female physicians publish fewer scientific articles than male physicians - a cross-sectional study.

Science.gov (United States)

Fridner, Ann; Norell, Alexandra; Åkesson, Gertrud; Gustafsson Sendén, Marie; Tevik Løvseth, Lise; Schenck-Gustafsson, Karin

2015-04-02

The proportion of women in medicine is approaching that of men, but female physicians are still in the minority as regards positions of power. Female physicians are struggling to reach the highest positions in academic medicine. One reason for the disparities between the genders in academic medicine is the fact that female physicians, in comparison to their male colleagues, have a lower rate of scientific publishing, which is an important factor affecting promotion in academic medicine. Clinical physicians work in a stressful environment, and the extent to which they can control their work conditions varies. The aim of this paper was to examine potential impeding and supportive work factors affecting the frequency with which clinical physicians publish scientific papers on academic medicine. Cross-sectional multivariate analysis was performed among 198 female and 305 male Swedish MD/PhD graduates. The main outcome variable was the number of published scientific articles. Male physicians published significantly more articles than female physicians p articles, as was collaborating with a former PhD advisor for both female physicians (OR = 2.97; 95% CI 1.22-7.20) and male physicians (OR = 2.10; 95% CI 1.08-4.10). Control at work was significantly associated with a higher number of published articles for male physicians only (OR = 1.50; 95% CI 1.08-2.09). Exhaustion had a significant negative impact on number of published articles among female physicians (OR = 0.29; 95% CI 0.12-0.70) whilst the publishing rate among male physicians was not affected by exhaustion. Women physicians represent an expanding sector of the physician work force; it is essential that they are represented in future fields of research, and in academic publications. This is necessary from a gender perspective, and to ensure that physicians are among the research staff in biomedical research in the future.

Career advising in family medicine: a theoretical framework for structuring the medical student/faculty advisor interview

Directory of Open Access Journals (Sweden)

Melissa Bradner

2013-08-01

Full Text Available Background: There are unique challenges to recruiting students into the specialty of family medicine within academic medical centers. Methods: At Virginia Commonwealth University, we developed an advising framework to help students address institutional and personal obstacles to choosing family medicine as a career. Results: The role of a faculty advisor is not to direct the student to a career choice but rather to foster a mentor relationship and help the student come to his or her own realizations regarding career choice. The faculty advisor/medical student interview is conceptualized as five discussion topics: self-knowledge, perception, organizational voice, cognitive dissonance, and anticipatory counseling. Conclusion: This framework is intended to assist faculty in their efforts to encourage students to consider a career in family medicine.

Thermal performance advisor expert system development

International Nuclear Information System (INIS)

McClintock, M.; Hirota, N.; Metzinger, R.

1991-01-01

In recent years the electric industry has developed an increased interest in improving efficiency of nuclear power plants. EPRI has embarked upon a research project RP2407, Nuclear Plant Performance Improvements which is designed to address needs in this area. One product of this project has been the Thermal Performance Diagnostic Manual for Nuclear Power Plants (NP-4990P). The purpose of this manual is to provide engineering personnel at nuclear power plants with a consistent way in which to identify thermal performance problems. General Physics is also involved in the development of another computer system called Fossil Thermal Performance Advisor (FTPA) which helps operators improve performance for fossil power plants. FTPA is a joint venture between General Physics and New York State Electric and Gas Company. This paper describes both of these computer systems and uses the FTPA as an interesting comparison that illustrates the considerations required for the development of a computer system that effectively addresses the needs of the users

Function of Nup98 subtypes and their fusion proteins, Nup98-TopIIβ and Nup98-SETBP1 in nuclear-cytoplasmic transport.

Science.gov (United States)

Saito, Shoko; Yokokawa, Takafumi; Iizuka, Gemmei; Cigdem, Sadik; Okuwaki, Mitsuru; Nagata, Kyosuke

2017-05-20

Nup98 is a component of the nuclear pore complex. The nup98-fusion genes derived by chromosome translocations are involved in hematopoietic malignancies. Here, we investigated the functions of Nup98 isoforms and two unexamined Nup98-fusion proteins, Nup98-TopIIβ and Nup98-SETBP1. We first demonstrated that two Nup98 isoforms are expressed in various mouse tissues and similarly localized in the nucleus and the nuclear envelope. We also showed that Nup98-TopIIβ and Nup98-SETBP1 are localized in the nucleus and partially co-localized with full-length Nup98 and a nuclear export receptor XPO1. We demonstrated that Nup98-TopIIβ and Nup98-SETBP1 negatively regulate the XPO1-mediated protein export. Our results will contribute to the understanding of the molecular mechanism by which the Nup98-fusion proteins induce tumorigenesis. Copyright © 2017 Elsevier Inc. All rights reserved.

STS-98 Destiny in Atlantis's payload bay

Science.gov (United States)

2001-01-01

KENNEDY SPACE CENTER, Fla. -- The U.S. Laboratory Destiny rests once again in Atlantis'''s payload bay, at Launch Pad 39A. Closing of the payload bay doors is imminent. Destiny, a key element in the construction of the International Space Station, is 28 feet long and weighs 16 tons. This research and command-and-control center is the most sophisticated and versatile space laboratory ever built. It will ultimately house a total of 23 experiment racks for crew support and scientific research. Destiny will be launched Feb. 7 on STS-98, the seventh construction flight to the ISS.

Elaboration et Suivi des Budgets de Marketing Industriel: le Système ADVISOR

OpenAIRE

Choffray, Jean-Marie; Delabre, Gilles

1982-01-01

Cet article revoit les problèmes posés par l'élaboration et le suivi des budgets de marketing dans un environnement industriel. Il présente le système ADVISOR pour lequel nous avons développé un programme interactif adapté aux besoins des entreprises Françaises.

ERAST: Scientific Applications and Technology Commercialization

Science.gov (United States)

Hunley, John D. (Compiler); Kellogg, Yvonne (Compiler)

2000-01-01

This is a conference publication for an event designed to inform potential contractors and appropriate personnel in various scientific disciplines that the ERAST (Environmental Research Aircraft and Sensor Technology) vehicles have reached a certain level of maturity and are available to perform a variety of missions ranging from data gathering to telecommunications. There are multiple applications of the technology and a great many potential commercial and governmental markets. As high altitude platforms, the ERAST vehicles can gather data at higher resolution than satellites and can do so continuously, whereas satellites pass over a particular area only once each orbit. Formal addresses are given by Rich Christiansen, (Director of Programs, NASA Aerospace Technology Ent.), Larry Roeder, (Senior Policy Advisor, U.S. Dept. of State), and Dr. Marianne McCarthy, (DFRC Education Dept.). The Commercialization Workshop is chaired by Dale Tietz (President, New Vista International) and the Science Workshop is chaired by Steve Wegener, (Deputy Manager of NASA ERAST, NASA Ames Research Center.

Partnering With a Family Advisor to Improve Communication in a Pediatric Intensive Care Unit.

Science.gov (United States)

Czulada, Laura; Leino, Patience; Willis, Tina Schade

2016-11-01

Inadequate communication between medical teams and families can lead to errors and poor-quality care. The objective was to understand why communication between the clinical team and families was not occurring consistently in the pediatric intensive care unit and improve the system using a multidisciplinary improvement team including a family advisor. This improvement project used Lean Six Sigma. The team observed updates and collected documented communication, survey, interview, and focus group data from families and staff. Root causes of failures included lack of assigned responsibility, lack of defined daily update, and lack of a daily communication standard. Process changes were implemented, resulting in an increased mean documented communication rate from 13% pre intervention to 65% post intervention that was sustained for more than 2 years (P < .001). Including a family advisor as an equal member of an improvement team provides family empowerment and a greater chance of success in complex areas. © The Author(s) 2015.

48 CFR 22.001 - Definitions.

Science.gov (United States)

2010-10-01

... PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS 22.001 Definitions. Administrator or... representative. e98 means the Department of Labor's approved electronic application (http://www.wdol.gov...Line (WDOL) means the Government Internet Web site for both Davis-Bacon Act and Service Contract Act...

Doctoral Advisor-Advisee Pairing in STEM Fields: Selection Criteria and Impact of Faculty, Student and Departmental Factors

Directory of Open Access Journals (Sweden)

Simy Joy

2015-09-01

Full Text Available Unlike the doctoral programs in places where students are paired with advisors at the time of admission itself, most US programs require the students to choose their advisors, and the advisors to formally accept the students as advisees. Little research has been done to understand how students and faculty approach this mutual selection and pairing process. This paper examines this process in STEM departments (Science, Technology, Engineering and Mathematics, with specific focus on factors influencing the decisions. Based on focus groups and interviews of doctoral students and faculty from STEM departments in an American university, we identify criteria applied by students and faculty in making their choices. Students were found to assess faculty on available funding, area of research, personality, ability to graduate students fast, and career prospects for students, and faculty to assess students on their qualifications/credentials and perceived ability to contribute to research. We also found that this mutual assessment was not objective, but influenced by perceptions associated with faculty gender and career stage, and student nationality. In the end, whether students and faculty were actually paired with persons of their choice depended on departmental factors including prevalent pairing practices, restrictions on student numbers per faculty, and reward structure. We discuss implications of the findings for research and practice.

Changes in Students' Views about Nature of Scientific Inquiry at a Science Camp

Science.gov (United States)

Leblebicioglu, G.; Metin, D.; Capkinoglu, E.; Cetin, P. S.; Eroglu Dogan, E.; Schwartz, R.

2017-12-01

Although nature of science (NOS) and nature of scientific inquiry (NOSI) are related to each other, they are differentiated as NOS is being more related to the product of scientific inquiry (SI) which is scientific knowledge whereas NOSI is more related to the process of SI (Schwartz et al. 2008). Lederman et al. (Journal of Research in Science Teaching, 51, 65-8, 2014) determined eight NOSI aspects for K-16 context. In this study, a science camp was conducted to teach scientific inquiry (SI) and NOSI to 24 6th and 7th graders (16 girls and 8 boys). The core of the program was guided inquiry in nature. The children working in small groups under guidance of science advisors conducted four guided-inquiries in the nature in morning sessions on nearby plants, animals, water, and soil. NOSI aspects were made explicit during and at the end of each inquiry session. Views about scientific inquiry (VASI) (Lederman et al. Journal of Research in Science Teaching, 51, 65-8, 2014) questionnaire was applied as pre- and post-test. The results of the study showed that children developed in all eight NOSI aspects, but higher developments were observed in "scientific investigations all begin with a question" and "there is no single scientific method," and "explanations are developed from data and what is already known" aspects. It was concluded that the science camp program was effective in teaching NOSI.

Representing Scientific Communities by Data Visualization (2/2)

CERN Multimedia

CERN. Geneva

2016-01-01

This work considers two types of communities as example: a scientific organization and an arising domain: the EPFL institutional community composed of faculty members and researchers and, at a world wide level, the emerging community of Digital Humanities researchers. For both cases, the research is organised as a process going from graphical research to actual materialization as physical artefacts (posters, maps, etc.), possibly extended using digital devices (augmented reality applications). T...

Proceedings of the Scientific Conference on Obscuration and Aerosol Research Held in Aberdeen Proving Ground, Maryland on June 22-25, 1992

Science.gov (United States)

1993-06-01

C. Carls) "Attachment of Ti02 powders to hollow glass microbeads:activity of the TiO2 -coated beads in the photoassisted oxidation of ethanol to...22) R. B. Gregory, and Y. Zhu, in Proc. 3rd Intl. Workshop on Positron and Positroniim Chemistry, edited by Y. C. Jean (World Scientific, Singapore...overlap in multicomponent systems. Factor analysis-rank annihilation (FARA) is an eigenanalysis technique 2-5 for analyzing two-dimensional data. FARA

OTA director to be Clinton's science advisor

Science.gov (United States)

Leath, Audrey

President Clinton has nominated John H. “Jack” Gibbons to be Assistant to the President for Science and Technology, and director of the White House Office of Science and Technology Policy (OSTP). For over a decade, Gibbons has served as director of the Office of Technology Assessment (OTA), a bipartisan research arm of Congress.In nominating Gibbons, Clinton said, “I am delighted to appoint a brilliant scientist and gifted administrator… It is profoundly important that the president have a science advisor who understands science, who understands technology, who understands the practical application of these disciplines to the myriad of problems we face today. And I can tell you that from [Vice-president] Al Gore on down to every other member of Congress I have discussed John Gibbons with, I have hardly ever received more glowing and more consistent recommendations for anyone.”

Rapid repair advisor for motor-operated valves

International Nuclear Information System (INIS)

Somsel, J.K.

1991-01-01

This paper reports on the initial proposed application for the Rapid Repair Advisor project for motor-operated valves (MOVs). The expected benefits from an MOV testing expert system depend on the purpose of the testing. Straight acceptance testing (post-maintenance and surveillance) could benefit from field verification of test validity. Troubleshooting of failed operators is seldom difficult. Intermittent problems are difficult to resolve suggesting that trace recording capabilities are needed. Predictive diagnosis places the most demands on the interpretive skills of the engineer. However, the limit to predictive capabilities seems to lie in the design of the MOV and the measurable parameters. Utilities are expected to require a knowledgeable MOV maintenance engineer to make decisions on MOV maintenance and operability. The economics of developing an expert system are comparable to improved training for the end-users

78 FR 77175 - Catalyst Capital Advisors LLC and Mutual Fund Series Trust; Notice of Application

Science.gov (United States)

2013-12-20

... SECURITIES AND EXCHANGE COMMISSION [Investment Company Act Release No. 30832; 812-14101] Catalyst... shareholder approval. APPLICANTS: Catalyst Capital Advisors LLC (``CCA'' or the ``Adviser'') and Mutual Fund Series Trust (formerly Catalyst Funds) (the ``Trust''). DATES: Filing Dates: The application was filed on...

Intracerebral infection of Cebus apella with the XJ-Clone 3 strain of Junín virus.

Science.gov (United States)

Carballal, G; Oubiña, J R; Molinas, F C; Nagle, C; de la Vega, M T; Videla, C; Elsner, B

1987-03-01

To assess the usefulness of the South American primate Cebus apella as a model for neurovirulence of Junín virus, eight monkeys were inoculated with 10(5) LD50 of the attenuated XJ-Clone 3 Junín virus strain by the intrathalamic route. After the second week, weight loss and polyadenopathies were observed in most animals, one-half of which had a transient leukothrombocytopenia. Moderate clinical central nervous system (CNS) involvement was present in four of eight monkeys, while the rest had only mild neurologic signs. All recovered except one, which developed a deep coma and was killed in a pre-mortem stage at 18 days post-infection (pi). Junín virus was isolated from the throat from five, from the blood from three, and from the brain from two monkeys. In the most severely ill animal, virus titers higher than viremia were detected in both inoculated and contralateral brain hemispheres, as well as in lung, lymph node, and small intestine. Junín antigens and "in vivo" bound immunoglobulins were detected by immunofluorescence (IF) in the brain of four animals at 18, 21, 40, and 155 days pi. Moderate lymphocytic parenchymal and meningeal infiltration were observed in the brain of four animals, and gliosis was also present in the most affected monkey. Although the clinical response to infection was not uniform, all infected monkeys developed high IF antibodies. Cebus apella cannot be used as a highly sensitive model for Argentine hemorrhagic fever (AHF). However, the results obtained show that the XJ-Clone 3 strain can replicate in the primate CNS and to induce lesions and immunoglobulin deposition. In addition, viral persistence is suggested by the late detection of viral antigens in brain at 40 and 155 days pi.

The Moderating Effect of Personality Traits on Advisor Relationships in Predicting Doctoral Student Burnout

Science.gov (United States)

Kosh, Emily P.

2014-01-01

Personality affects relationships. During the doctoral education, the second most important factor in degree completion, after financial support, is the student-advisor relationship. Approximately half of doctoral students do not finish their degrees. While it is known mentors have a profound impact on the success of doctoral students, the effect…

The Northern States Power Company welding manual advisor

International Nuclear Information System (INIS)

Lu, Yi; Wood, R.M.

1993-01-01

The Welding Manual Advisor (WMA) is an object oriented expert system designed to assist Northern States Power (NSP) personnel in implementing the company's Welding Manual. The expert system captures the knowledge of welding experts, addresses important issues in welding activities and automates the use of the Welding Manual. It is estimated that use of the WMA will save $81,000 over the next six years at NSP, because of the reduction of labor and errors in the use of the Welding Manual, and facilitation of training of NSP personnel. The important features of the WMA include the accuracy and consistency in determining welding procedure and requirements, update capability, user friendly interface, on-line help function, back-up capability, and well-documented manuals

Robo advisor, your reliable partner? Building a trustworthy digital investment management service

OpenAIRE

Salo, Anni

2017-01-01

Investment management services have strongly relied on traditional face-to-face business models, causing the services being highly expensive and therefore available only for the wealthiest population. Recently a new digital business model, robo advisors, entered the market and are predicted to democratise the entire industry by bringing investment management services available to a wider public than ever before. Although the business models in financial services are changing, customer tr...

About the 'scientification' of politics by way of scientific expertise by advisory bodies. Social science expertise and desicion-making in social problem areas in the Federal Republic of Germany

International Nuclear Information System (INIS)

Wagner, P.

1985-01-01

Taking the examples of the Council of Economic Advisors, the Education Council and the Federal Parliament's Commission of Inquiry on Future Nuclear Energy Policy, this paper analyses political situations in the Federal Republic of Germany in which social science expertise entered public debate and decision-making in certain social problem areas in a very pronounced way. By considering the social context in which these advisory bodies were created, an attempt is made to link an analysis of different social actors' interests to a review of existing knowledge and patterns of interpretation in the social sciences. It is shown that by using social science findings some actors achieved advantages in justifying and legitimating their political positions and that subsequently the relations of actors in some arenas of conflict changed-without, however, allowing to relate this causally only to the use of scientific knowledge. If, however, the use of scientific arguments is rapidly generalized, the confrontation of expertise and counter-expertise by opposing actors becomes usual practice. This, in turn, provides for questions concerning their 'scientificity', which the social sciences are asked to take up in reflections of their relation to social practice. (orig./HSCH) [de

Estructura del macrobentos de la laguna de Paca, Junín

Directory of Open Access Journals (Sweden)

Pedro Huamán

2013-06-01

Full Text Available Se caracterizó la estructura comunitaria del macrobentos de la laguna de Paca ubicada a 3364 msnm, a 11º 45 S y 75º 30’ W en el departamento de Junín-Perú. También se analizaron los principales factores físicos y químicos del agua y sedimentos que condicionan dicha estructura. Los muestreos se realizaron en el año 2000 en 8 estaciones, distribuidas en la zona litoral (5 y pelágica (3. En cada estación se tomaron muestras de agua cercana al fondo y de sedimentos para analizar los parámetros físicos, químicos y biológicos de la comunidad del macrobentos. Los datos fueron sometidos a pruebas univariadas y multivariadas para determinar el grado de interacción de los diversos factores con las variables biológicas. La diversidad del macrobentos es baja y muestra valores de diversidad menores a 1,5 y el número de especies menores a 11 especies. La abundancia varía en valores que van desde los 16 hasta 176 individuos/0,04 m2 . Tubifex tubifex y Chironomus sp. fueron las especies más resistentes a los altos valores de materia orgánica (35,22 a 38,28% y bajos valores de oxígeno disuelto (1 a 2 mg/L, lo que constituye indicadores biológicos de eutroficación.

Scientific-creative thinking and academic achievement

Directory of Open Access Journals (Sweden)

Rosario Bermejo

2014-07-01

Full Text Available The aim of this work is to study the relationship between scientific-creative thinking construct and academic performance in a sample of adolescents. In addition, the scientific-creative thinking instrument’s reliability will be tested. The sample was composed of 98 students (aged between 12-16 years old attending to a Secondary School in Murcia Region (Spain. The used instruments were: a the Scientific-Creative Thinking Test designed by Hu and Adey (2002, which was adapted to the Spanish culture by the High Abilities research team at Murcia University. The test is composed of 7 task based in the Scientific Creative Structure Model. It assesses the dimensions fluency, flexibility and originality; b The General and Factorial Intelligence Test (IGF/5r; Yuste, 2002, which assess the abilities of general intelligence and logic reasoning, verbal reasoning, numerical reasoning and spatial reasoning; c Students’ academic achievement by domains (scientific-technological, social-linguistic and artistic was collected. The results showed positive and statistical significant correlations between the scientific-creative tasks and academic achievement of different domains.

Using c-Jun to identify fear extinction learning-specific patterns of neural activity that are affected by single prolonged stress.

Science.gov (United States)

Knox, Dayan; Stanfield, Briana R; Staib, Jennifer M; David, Nina P; DePietro, Thomas; Chamness, Marisa; Schneider, Elizabeth K; Keller, Samantha M; Lawless, Caroline

2018-04-02

Neural circuits via which stress leads to disruptions in fear extinction is often explored in animal stress models. Using the single prolonged stress (SPS) model of post traumatic stress disorder and the immediate early gene (IEG) c-Fos as a measure of neural activity, we previously identified patterns of neural activity through which SPS disrupts extinction retention. However, none of these stress effects were specific to fear or extinction learning and memory. C-Jun is another IEG that is sometimes regulated in a different manner to c-Fos and could be used to identify emotional learning/memory specific patterns of neural activity that are sensitive to SPS. Animals were either fear conditioned (CS-fear) or presented with CSs only (CS-only) then subjected to extinction training and testing. C-Jun was then assayed within neural substrates critical for extinction memory. Inhibited c-Jun levels in the hippocampus (Hipp) and enhanced functional connectivity between the ventromedial prefrontal cortex (vmPFC) and basolateral amygdala (BLA) during extinction training was disrupted by SPS in the CS-fear group only. As a result, these effects were specific to emotional learning/memory. SPS also disrupted inhibited Hipp c-Jun levels, enhanced BLA c-Jun levels, and altered functional connectivity among the vmPFC, BLA, and Hipp during extinction testing in SPS rats in the CS-fear and CS-only groups. As a result, these effects were not specific to emotional learning/memory. Our findings suggest that SPS disrupts neural activity specific to extinction memory, but may also disrupt the retention of fear extinction by mechanisms that do not involve emotional learning/memory. Copyright © 2017 Elsevier B.V. All rights reserved.

78 FR 69155 - Altegris Advisors, L.L.C., et al.; Notice of Application

Science.gov (United States)

2013-11-18

... Advisors, L.L.C., et al.; Notice of Application November 12, 2013. AGENCY: Securities and Exchange..., under sections 6(c) and 17(b) of the Act for an exemption from sections 17(a)(1) and (2) of the Act, and under section 6(c) of the Act for an exemption from rule 12d1- 2(a) under the Act. Summary of...

A preliminary study on coloring mechanism of Jun copper red glaze

International Nuclear Information System (INIS)

Tian Shibing; Liu Yuzhen; Zhang Maolin; Wang Lihua; Wang Cangsui; Xie Yaning

2009-01-01

The origin of a red color glazes decorated on the ancient Jun porcelain has been attributed to the presence of combined copper clusters and cuprous oxide, or cuprous oxide alone. For better understanding of the color-forming mechanism, X-ray absorption at the Cu-edge by the red area of a Jun porcelain shard was carried out. By comparing the XANFS spectra of the sample with metal copper and cubic Cu 2 O, we found that the spectra of the red layer of sample were similar to the spectrum combination of 37% Cu 2 O and 63% metal copper,while the spectra from surface of the red spot mainly resembled that of cubic Cu 2 O. The EXAFS results showed that monovalence copper cations were isolated in the glaze matrix, and copper atoms were formed to metallic copper clusters or mutimers dominantly distributed in the inner layer. These can be responsible to the optical properties of the red decoration with the presence of colloidal composition containing copper particles and the Cu + ions. In conclusion, a preliminary non-destructive elemental analysis using synchrotron radiation-induce X-ray fluorescence (SR-XRF) is demonstrated, and mechanism about the formation of the complicated structures is discussed. (authors)

Fibroin and sericin from Bombyx mori silk stimulate cell migration through upregulation and phosphorylation of c-Jun.

Directory of Open Access Journals (Sweden)

Celia Martínez-Mora

Full Text Available Wound healing is a biological process directed to the restoration of tissue that has suffered an injury. An important phase of wound healing is the generation of a basal epithelium able to wholly replace the epidermis of the wound. A broad range of products derived from fibroin and sericin from Bombyx mori silk are used to stimulate wound healing. However, so far the molecular mechanism underlying this phenomenon has not been elucidated. The aim of this work was to determine the molecular basis underlying wound healing properties of silk proteins using a cell model. For this purpose, we assayed fibroin and sericin in a wound healing scratch assay using MDA-MB-231 and Mv1Lu cells. Both proteins stimulated cell migration. Furthermore, treatment with sericin and fibroin involved key factors of the wound healing process such as upregulation of c-Jun and c-Jun protein phosphorylation. Moreover, fibroin and sericin stimulated the phosphorylation of ERK 1/2 and JNK 1/2 kinases. All these experiments were done in the presence of specific inhibitors for some of the cell signalling pathways referred above. The obtained results revealed that MEK, JNK and PI3K pathways are involved in fibroin and sericin stimulated cells migration. Inhibition of these three kinases prevented c-Jun upregulation and phosphorylation by fibroin or sericin. Fibroin and sericin were tested in the human keratinocyte cell line, HaCaT, with similar results. Altogether, our results showed that fibroin and sericin initiate cell migration by activating the MEK, JNK and PI3K signalling pathways ending in c-Jun activation.

Doing Research Together: A Study on the Views of Advisors with Intellectual Disabilities and Non-Disabled Researchers Collaborating in Research.

Science.gov (United States)

Puyalto, Carol; Pallisera, Maria; Fullana, Judit; Vilà, Montserrat

2016-03-01

Despite an increase in inclusive studies in recent years, research on the views of the people with and without disabilities who have participated in these studies is scarce. The aim of this study was to explore the perceptions and views of advisors with intellectual disabilities and non-disabled researchers who collaborated together on a joint project to study transition to adulthood. Two questionnaires were devised, one for advisors and one for researchers; two focus groups were held with people with intellectual disabilities, three focus groups with researchers, and one focus group with all participants together. Thematic analysis was used for the data analysis. The advisors valued this experience as an opportunity to learn new skills, freely express themselves on matters that affect them, and engage in a socially valued activity. The researchers considered that the participation of people with intellectual disabilities contributed to improving the quality of the research. The study provides a better understanding of inclusive research processes by taking into account participants' views. © 2015 John Wiley & Sons Ltd.

Does young adults' preferred role in decision making about health, money, and career depend on their advisors' leadership skills?

Science.gov (United States)

Garcia-Retamero, Rocio; Galesic, Mirta

2013-01-01

Few empirical data exist on how decision making about health differs from that in other crucial life domains with less threatening consequences. To shed light on this issue we conducted a study with 175 young adults (average age 19 years). We presented the participants with scenarios involving advisors who provided assistance in making decisions about health, money, and career. For each scenario, participants were asked to what extent they wanted the advisor to exhibit several leadership styles and competencies and what role (active, collaborative, or passive) they preferred to play when making decisions. Results show that decision making about health is distinct from that in the other domains in three ways. First, most of the participants preferred to delegate decision making about their health to their physician, whereas they were willing to collaborate or play an active role in decision making about their career or money. Second, the competencies and leadership style preferred for the physician differed substantially from those desired for advisors in the other two domains: Participants expected physicians to show more transformational leadership--the style that is most effective in a wide range of environments--than those who provide advice about financial investments or career. Finally, participants' willingness to share medical decision making with their physician was tied to how strongly they preferred that the physician shows an effective leadership style. In contrast, motivation to participate in decision making in the other domains was not related to preferences regarding advisors' leadership style or competencies. Our results have implications for medical practice as they suggest that physicians are expected to have superior leadership skills compared to those who provide assistance in other important areas of life.

Cordyceps militaris Fraction induces apoptosis and G2/M Arrest via c-Jun N-Terminal kinase signaling pathway in oral squamous carcinoma KB Cells.

Science.gov (United States)

Xie, Wangshi; Zhang, Zhang; Song, Liyan; Huang, Chunhua; Guo, Zhongyi; Hu, Xianjing; Bi, Sixue; Yu, Rongmin

2018-01-01

Cordyceps militaris fraction (CMF) has been shown to possess in vitro antitumor activity against human chronic myeloid leukemia K562 cells in our previous research. The in vitro inhibitory activities of CMF on the growth of KB cells were evaluated by viability assay. The apoptotic and cell cycle influences of CMF were detected by 4',6-diamidino-2-phenylindole staining and flow cytometry assay. The expression of different apoptosis-associated proteins and cell cycle regulatory proteins was examined by Western blot assay. The nuclear localization of c-Jun was observed by fluorescence staining. The objective of this study was to investigate the antiproliferative effect of CMF as well as the mechanism underlying the apoptosis and cell cycle arrest it induces in KB cells. CMF suppressed KB cells' proliferation in a dose- and time-dependent manner. Flow cytometric analysis indicated that CMF induced G2/M cell cycle arrest and apoptosis. Western blot analysis revealed that CMF induced caspase-3, caspase-9, and PARP cleavages, and increased the Bax/Bcl-2 ratio. CMF also led to increased expression of p21, decreased expression of cyclin B1, mitotic phosphatase cdc25c, and mitotic kinase cdc2, as well as unchanged expression of p53. In addition, CMF stimulated c-Jun N-terminal kinases (JNK) protein phosphorylations, resulting in upregulated expression of c-Jun and nuclear localization of c-Jun. Pretreatment with JNK inhibitor SP600125 suppressed CMF-induced apoptosis and G2/M arrest. CMF is capable of modulating c-Jun caspase and Bcl-2 family proteins through JNK-dependent apoptosis, which results in G2/M phase arrest in KB cells. CMF could be developed as a promising candidate for the new antitumor agents. CMF exhibited strong anticancer activity against oral squamous carcinoma KB cellsCMF inhibited KB cells' proliferation via induction of apoptosis and G2/M cell cycle arrestCMF activated JNK signaling pathway and promoted the nuclear localization of c-JunCMF regulated the

Junções de materiais dissimilares utilizando o processo de soldagem por fricção rotativa

OpenAIRE

Eder Paduan Alves

2010-01-01

O objetivo desse trabalho é o desenvolvimento de junções no estado sólido de materiais dissimilares alumínio AA 1050 e aço inoxidável AISI 304, que possam ser utilizadas nas tubulações de reservatórios de propelentes líquidos e demais tubulações dos Veículos Lançadores de Satélites. As junções foram obtidas pelo processo de soldagem por fricção rotativa convencional, que combina o calor gerado entre o atrito de duas superfícies e deformação mecânica. Foram realizados testes de soldagem com di...

77 FR 66651 - Salient Advisors, L.P. and MarketShares ETF Trust; Notice of Application

Science.gov (United States)

2012-11-06

... Advisors, L.P. and MarketShares ETF Trust; Notice of Application October 31, 2012 AGENCY: Securities and... ETF Trust (the ``Trust''). Summary of Application: Applicants request an order that permits: (a... statutory trust. The Trust will initially offer one series, the Salient MLP and Energy Infrastructure ETF...

An insight into the emerging role of regional medical advisor in the pharmaceutical industry

Directory of Open Access Journals (Sweden)

Sandeep Kumar Gupta

2013-01-01

Full Text Available The position of regional medical advisor (RMA is relatively new in the pharmaceutical industry and its roles and responsibility are still evolving. The RMA is a field based position whose main mission is to foster collaborative relationships with the key opinion leaders (KOLs and to facilitate the exchange of unbiased scientific information between the medical community and the company. Field-based medical liaison teams are expanding world-wide as part of the pharmaceutical industry′s increased focus on global operations including emerging markets. Now, the position of the RMA has evolved into comprehensive, complex, highly interactive, targeted, highly strategic, innovative, and independent role since its inception by the Upjohn Company in 1967. The major objective of the RMA is to develop the professional relationships with the health-care community, particularly KOLs, through peer-to-peer contact. The RMA can facilitate investigator-initiated clinical research proposals from approval until completion, presentation, and publication. It is possible for a RMA to have valuable access to KOLs through his expertise in the clinical research. The RMA can assist in the development, review, and follow-up of the clinical studies initiated within the relevant therapeutic area at the regional/local level. The RMA can lead regional/local clinical projects to ensure that all clinical trials are conducted in compliance with the International Conference of Harmonisation Good Clinical Practice (ICH GCP guidelines.

Theoretical construction of the contextualized dynamics of the constant shaping of advisor professors in the teaching unit

Directory of Open Access Journals (Sweden)

Nirma Pérez-Pelipiche

2016-10-01

Full Text Available This work paper shows research results on the contextualized dynamics of the constant shaping of advisor professors in the teaching unit, taking epistemological foundations as a starting point, which substantiate their theoretical construction. A model has been displayed basing on comprehension and interpretation of this process as a whole, in which its subsystems, components, structure, relations and levels among them, prove contradictions that become evident in such process, therefore allowing to structure the dynamics of shaping professors as an instrument, earning, as a result, the transforming capability of advisor professors when practicing their skill, having the teaching unit as a scenary. In that way we used different techniques: questionnaire, interviews, observation, statistical techniques and methods: historical-logical; analysis-synthesis and systemic-structural-functional, all of those ones from the hermeneutic-dialectic focus.

International Symposium on Scientific Computing, Computer Arithmetic and Validated Numerics

CERN Document Server

DEVELOPMENTS IN RELIABLE COMPUTING

1999-01-01

The SCAN conference, the International Symposium on Scientific Com­ puting, Computer Arithmetic and Validated Numerics, takes place bian­ nually under the joint auspices of GAMM (Gesellschaft fiir Angewandte Mathematik und Mechanik) and IMACS (International Association for Mathematics and Computers in Simulation). SCAN-98 attracted more than 100 participants from 21 countries all over the world. During the four days from September 22 to 25, nine highlighted, plenary lectures and over 70 contributed talks were given. These figures indicate a large participation, which was partly caused by the attraction of the organizing country, Hungary, but also the effec­ tive support system have contributed to the success. The conference was substantially supported by the Hungarian Research Fund OTKA, GAMM, the National Technology Development Board OMFB and by the J6zsef Attila University. Due to this funding, it was possible to subsidize the participation of over 20 scientists, mainly from Eastern European countries. I...

An intelligent, knowledge-based multiple criteria decision making advisor for systems design

Science.gov (United States)

Li, Yongchang

of an appropriate decision making method. Furthermore, some DMs may be exclusively using one or two specific methods which they are familiar with or trust and not realizing that they may be inappropriate to handle certain classes of the problems, thus yielding erroneous results. These issues reveal that in order to ensure a good decision a suitable decision method should be chosen before the decision making process proceeds. The first part of this dissertation proposes an MCDM process supported by an intelligent, knowledge-based advisor system referred to as Multi-Criteria Interactive Decision-Making Advisor and Synthesis process (MIDAS), which is able to facilitate the selection of the most appropriate decision making method and which provides insight to the user for fulfilling different preferences. The second part of this dissertation presents an autonomous decision making advisor which is capable of dealing with ever-evolving real time information and making autonomous decisions under uncertain conditions. The advisor encompasses a Markov Decision Process (MDP) formulation which takes uncertainty into account when determines the best action for each system state. (Abstract shortened by UMI.)

The Advisor as Servant: The Theoretical and Philosophical Relevance of Servant Leadership to Academic Advising

Science.gov (United States)

McClellan, Jeffrey L.

2007-01-01

Servant. This novel actively portrays Greenleaf's concept of servant leadership by describing the extracurricular work of a university professor. Consequently, some scholars have demonstrated the relevance of servant leadership to classroom instruction (Powers & Moore, 2005). However, it was not as an instructor, but as an advisor that the…

76 FR 32933 - International Standard-Setting Activities

Science.gov (United States)

2011-06-07

... is REP 11/EURO. The Committee agreed to nominate Poland for appointment as the Regional Coordinator... Food Hygiene Emilio Esteban, DVM, MBA, MPVM, PhD, Scientific Advisor for Laboratory Services & Research..., Scientific Advisor for Risk Assessment, Office of Public Health Science, Food Safety and Inspection Service...

Thermodynamic analysis of the heterodimerization of leucine zippers of Jun and Fos transcription factors

International Nuclear Information System (INIS)

Seldeen, Kenneth L.; McDonald, Caleb B.; Deegan, Brian J.; Farooq, Amjad

2008-01-01

Jun and Fos are components of the AP1 family of transcription factors and bind to the promoters of a diverse multitude of genes involved in critical cellular responses such as cell growth and proliferation, cell cycle regulation, embryonic development and cancer. Here, using the powerful technique of isothermal titration calorimetry, we characterize the thermodynamics of heterodimerization of leucine zippers of Jun and Fos. Our data suggest that the heterodimerization of leucine zippers is driven by enthalpic forces with unfavorable entropy change at physiological temperatures. Furthermore, the basic regions appear to modulate the heterodimerization of leucine zippers and may undergo at least partial folding upon heterodimerization. Large negative heat capacity changes accompanying the heterodimerization of leucine zippers are consistent with the view that leucine zippers do not retain α-helical conformations in isolation and that the formation of the native coiled-coil α-helical dimer is attained through a coupled folding-dimerization mechanism

Career Preparation: An Often Omitted Element of the Advisor-Graduate Student Relationship

Science.gov (United States)

McManus, D. A.

2001-05-01

Most graduate research advisors care about the education of their graduate students. However, they often define "graduate education" so narrowly that it consists only of solving a research problem. This narrow definition is consistent with their principal goal as geoscientists, to understand the Earth better, and with the reward system typical of research universities, with its emphasis on research. As a result, most advisors usually well prepare students to be researchers in research universities. Research, however, is only part of a faculty member's duties. Commonly omitted is mentoring in the teaching and service duties of a faculty member. Students interested in teaching, in positions in other academic institutions, or in careers outside of academia may be perceived as questioning the advisors' career values and may not be encouraged in these interests. Graduate students should take an active role in their education. In addition to seeking information on career preparation from the campus career center and teaching center and from books, newsmagazines, newspapers, and seminars, students should also seek mentors who have demonstrated an interest in what the student is interested in: teaching and service, as well as research, or in careers outside academia. These mentors may be the students' committee members, other faculty members, or other professional geoscientists. With a broad base of information and some personal decisions, students will have a rationale for exploring careers. The questions students ask can now be more specific: How do they gain the requisite breadth in knowledge and the beneficial skills, beyond the depth of the research experience, and how do they gain opportunities to practice these skills? In short, how can they experience, and preferably practice, what professional geoscientists do in particular careers? If necessary, graduate students can work together to answer these questions by inviting experts to offer workshops in the department

Laboratory directed research and development FY98 annual report; TOPICAL

International Nuclear Information System (INIS)

Al-Ayat, R; Holzrichter, J

1999-01-01

In 1984, Congress and the Department of Energy (DOE) established the Laboratory Directed Research and Development (LDRD) Program to enable the director of a national laboratory to foster and expedite innovative research and development (R and D) in mission areas. The Lawrence Livermore National Laboratory (LLNL) continually examines these mission areas through strategic planning and shapes the LDRD Program to meet its long-term vision. The goal of the LDRD Program is to spur development of new scientific and technical capabilities that enable LLNL to respond to the challenges within its evolving mission areas. In addition, the LDRD Program provides LLNL with the flexibility to nurture and enrich essential scientific and technical competencies and enables the Laboratory to attract the most qualified scientists and engineers. The FY98 LDRD portfolio described in this annual report has been carefully structured to continue the tradition of vigorously supporting DOE and LLNL strategic vision and evolving mission areas. The projects selected for LDRD funding undergo stringent review and selection processes, which emphasize strategic relevance and require technical peer reviews of proposals by external and internal experts. These FY98 projects emphasize the Laboratory's national security needs: stewardship of the U.S. nuclear weapons stockpile, responsibility for the counter- and nonproliferation of weapons of mass destruction, development of high-performance computing, and support of DOE environmental research and waste management programs

Decommissioning economic risk advisor: DERAD Version 1.0 user's manual. Final report

International Nuclear Information System (INIS)

Gjerde, A.R.; Qian, M.; Govil, P.; Balson, W.E.

1995-04-01

DERAD - Decommissioning Economic and Risk ADvisor - is a decision support tool designed to help utility decision makers analyze economics and financial risk of decommissioning nuclear power plants. Your current copy of DERAD, Version 1.0, is customized for PWR configurated plants. DERAD has been developed by Decision Focus Incorporated under EPRI sponsorship. If you have ideas or recommendations for how we can improve and enhance future versions of DERAD, we would like to hear from you

78 FR 29399 - ERNY Financial ETF Trust and ERNY Financial Advisors, LLC; Notice of Application

Science.gov (United States)

2013-05-20

... Financial ETF Trust and ERNY Financial Advisors, LLC; Notice of Application May 13, 2013. AGENCY: Securities... for an exemption from sections 12(d)(1)(A) and (B) of the Act. Applicants: ERNY Financial ETF Trust... ETF (the ``Initial Fund''), the investment objective of which will be to seek long-term capital...

Human-scientific Planning Theory

OpenAIRE

Hagen, Aksel

1998-01-01

This working report is a paper written to XII AESOP Congress 22 – 25 July 1998, Aveiro, Portugal. It is a presentation of human-scientific action theory and its linkage to planning, both planning theory and planning practice. Human-scientific action theory is created by professor Gunnar Olsson and professor José Luis Ramírez, Nordic School of Planning, Stockholm. Planning is primarily a practical and reflective activity. The notion ”Planning” may, therefore, describe the activi...

The intriguing role of fibroblasts and c-Jun in the chemopreventive and therapeutic effect of finasteride on xenograft models of prostate cancer

Directory of Open Access Journals (Sweden)

Yi-Nong Niu

2016-01-01

Full Text Available In a large clinical trial, finasteride reduced the rate of low-grade prostate cancer (PCa while increasing the incidence of high-grade cancer. Whether finasteride promotes the development of high-grade tumors remains controversial. We demonstrated the role of fibroblasts and c-Jun in chemopreventive and therapeutic effect of finasteride on xenograft models of PCa. LNCaP (PC3 cells or recombinants of cancer cells and fibroblasts were implanted in male athymic nude mice treated with finasteride. Tumor growth, cell proliferation, apoptosis, p-Akt, and p-ERK1/2 were evaluated. In LNCaP (PC3 mono-grafted models, finasteride did not change the tumor growth. In recombinant-grafted models, fibroblasts and c-Jun promoted tumor growth; finasteride induced proliferation of LNCaP cells and repressed PC3 cell apoptosis. When c-Jun was knocked out, fibroblasts and/or finasteride did not promote the tumor growth. Finasteride inhibited p-Akt and p-ERK1/2 in mono-culture cancer cells while stimulating the same signaling molecules in the presence of fibroblasts. Reduced p-Akt and p-ERK1/2 were noted in the presence of c-Jun−/− fibroblasts. Fibroblasts and c-Jun promote PCa growth; finasteride further stimulates tumor growth with promoted proliferation, repressed apoptosis, and up-regulated pro-proliferative molecular pathway in the presence of fibroblasts and c-Jun. Stromal-epithelial interactions play critical roles in finasteride′s therapeutic effects on PCa. Our findings have preliminary implications in using finasteride as a chemopreventive or therapeutic agent for PCa patients.

Retrospective Review of Student Research Projects in a Canadian Master of Science in Physical Therapy Programme and the Perceived Impact on Advisors' Research Capacity, Education, Clinical Practice, Knowledge Translation, and Health Policy.

Science.gov (United States)

Lacey, Courtney; Scodras, Stephanie; Ardron, Julie; Sellan, Ryan; Garbaczewska, Martyna; O'Brien, Kelly K; Salbach, Nancy M

2018-01-01

Purpose: This study's aim was to characterize the nature of students' research conducted for a Master of Science in Physical Therapy (MScPT) degree programme at a Canadian university and evaluate the lead advisors' perspectives of its impact on their research capacity, education, clinical practice, knowledge translation, and health policy. Methods: We conducted a quantitative, cross-sectional, retrospective review of research reports from 2003 to 2014 to characterize the MScPT students' research and a quantitative, cross-sectional e-survey of lead research advisors to evaluate the impact of this research. Results: Data were abstracted from reports of 201 research projects completed between 2003 and 2014. Projects were conducted primarily in university-affiliated hospitals (41.6%) or the university's physical therapy department (41.1%), and the majority (52.5%) had a clinical focus. Of the 95 lead advisors of 201 projects, 59 advisors (response rate 62.1%) of 119 projects completed the survey questionnaire. The respondents most frequently identified clinical practice (45.1%) and advisors' research capacity (31.4%) as areas positively affected by the students' research. Conclusions: The MScPT students' research projects facilitate the conduct of extensive research internally and across affiliated hospitals. This research appears to advance not only clinical practice but also the ability of lead advisors to undertake research.

Activation of JNK and c-Jun is involved in glucose oxidase-mediated cell death of human lymphoma cells.

Science.gov (United States)

Son, Young-Ok; Jang, Yong-Suk; Shi, Xianglin; Lee, Jeong-Chae

2009-12-31

Mitogen-activated protein kinases (MAPK) affect the activation of activator protein-1 (AP-1), which plays an important role in regulating a range of cellular processes. However, the roles of these signaling factors on hydrogen peroxide (H(2)O(2))-induced cell death are unclear. This study examined the effects of H(2)O(2) on the activation of MAPK and AP-1 by exposing the cells to H(2)O(2) generated by either glucose oxidase or a bolus addition. Exposing BJAB or Jurkat cells to H(2)O(2) affected the activities of MAPK differently according to the method of H(2)O(2) exposure. H(2)O(2) increased the AP-1-DNA binding activity in these cells, where continuously generated H(2)O(2) led to an increase in mainly the c-Fos, FosB and c-Jun proteins. The c-Jun-NH(2)-terminal kinase (JNK)-mediated activation of c-Jun was shown to be related to the H(2)O(2)-induced cell death. However, the suppression of H(2)O(2)-induced oxidative stress by either JNK inhibitor or c-Jun specific antisense transfection was temporary in the cells exposed to glucose oxidase but not to a bolus H(2)O(2). This was associated with the disruption of death signaling according to the severe and prolonged depletion of reduced glutathione. Overall, these results suggest that H(2)O(2) may decide differently the mode of cell death by affecting the intracellular redox state of thiol-containing antioxidants, and this depends more closely on the duration exposed to H(2)O(2) than the concentration of this agent.

76 FR 33376 - Altegris Advisors, L.L.C. and Northern Lights Fund Trust; Notice of Application

Science.gov (United States)

2011-06-08

... the Fund and its shareholders, and does not involve a conflict of interest from which the Adviser or... amend subadvisory agreements without shareholder approval. Applicants: Altegris Advisors, L.L.C. (the.... Interested persons may request a hearing by writing to the Commission's Secretary and serving applicants with...

Culturally Competent Training Program: A Key to Training Lay Health Advisors for Promoting Breast Cancer Screening

Science.gov (United States)

Yu, Mei-yu; Song, Lixin; Seetoo, Amy; Cai, Cuijuan; Smith, Gary; Oakley, Deborah

2007-01-01

The lay health advisor (LHA) training program for breast cancer screening was conducted among Chinese-English bilingual trainees residing in Southeast Michigan. Guided by Bandura's Social Learning Theory, the development of the training curriculum followed the health communication process recommended by the National Cancer Institute. Data analysis…

John F. Simon, jr. / John F. jun. Simon ; interv. Tilman Baumgärtel

Index Scriptorium Estoniae

Simon, John F. jun.

2006-01-01

Ameerika kunstnikust-programmeerijast Jon F. Simon juuniorist (sünd. 1963), tema loomingust, vestlus kunstnikuga 19. 12. 1999. a. tema ateljees. J. F. Simon jun.-i teosed on tarkvara. Monitoril tekkinud kujutisi on kunstnik eksponeerinud nimetuse "Panels" all. Kunstniku joonistusprogrammist, arvutiprogrammist "Every Icon", mis asub Internetis, tööst "Combination", võrgutööst "Alter Stars" (1995-1998) ja muust

Bridge over troubled water - valuing Russia's scientific landscape

Czech Academy of Sciences Publication Activity Database

Büntgen, Ulf

2016-01-01

Roč. 70, č. 1 (2016), s. 95-98 ISSN 0936-577X R&D Projects: GA MŠk(CZ) LO1415 Institutional support: RVO:67179843 Keywords : Environmental change * Brain drain * Interdisciplinary research * Paleo-archives * Russia * Scientific collaboration Subject RIV: EH - Ecology, Behaviour Impact factor: 1.578, year: 2016

Shift technical advisors: in the eyes of the NRC

International Nuclear Information System (INIS)

Crocker, L.P.

1981-01-01

Since January 1, 1980, the NRC has required that Shift Technical Advisors be on-shift at all operating nuclear power plants. The objective of the requirement is to assure that technical expertise is immediately available to each operating shift to assess off-normal events and to provide advice to control room personnel. Further, this advice and assistance is to be provided by an individual not responsible for control manipulations or for directing the activities of reactor operators. The long-term requirement for on-shift technical expertise is firm. However, the exact manner in which this expertise must be furnished has not been determined. Licensees have proposed various alternatives to meet this requirement. These proposals still are being reviewed by the NRC staff

77 FR 60732 - PACE Select Advisors Trust and UBS Global Asset Management (Americas) Inc.; Notice of Application

Science.gov (United States)

2012-10-04

....; Institutional Capital, LLC; J.P. Morgan Investment Management, Inc.; Kayne Anderson Rudnick Investment...; Standish Mellon Asset Management Company, LLC; Systematic Financial Management, L.P.; Wellington Management... Select Advisors Trust and UBS Global Asset Management (Americas) Inc.; Notice of Application September 27...

CERN Technical training: Available places in forthcoming courses

CERN Multimedia

HR Department

2010-01-01

The following course sessions are scheduled in the framework of the 2010 CERN Technical Training Programme and places are still available. You can find the full updated Technical Training course programme in our web catalogue. Software and system technologies Certification: Ingénieur en Sécurité Fonctionnelle\t07-JUN-10\t10-JUN-10\tFrench\t3.5 jours Emacs - way beyond Text Editing\t16-JUL-10\t16-JUL-10\tEnglish\t1 day ITIL Foundations (version 3)\t31-MAY-10\t02-JUN-10\tEnglish\t3 days ITIL Foundations (version 3) EXAMINATION\t22-JUN-10\t22-JUN-10\tEnglish\t1 hour JAVA - Level 2\t05-JUL-10\t08-JUL-10\tEnglish\t4 days JAVA 2 Enterprise Edition - Part 2: Enterprise JavaBeans\t21-JUN-10\t23-JUN-10\tEnglish\t3 days JCOP - Finite State Machines in the JCOP Framework\t22-JUN-10\t24-JUN-10\tEnglish\t3 days Le Langage C (ANSI et C99)\t24-JUN-10\t02-JUL-10\tEnglish\t4 days Oracle - Programming with PL/SQL\t28-JUN-10\t30-JUN-10\tEnglish\t3 days Oracle Certified Professional\t07-JUN-10\t11-JUN-10\tEnglish\t5 days Project Devel...

Teachers Providing Social and Emotional Support: A Study of Advisor Role Enactment in Small High Schools

Science.gov (United States)

Phillippo, Kate L.

2010-01-01

Background/Context: This study investigates the teacher's role in the student advisory process, which to date has generated limited research literature. Teachers who serve as student advisors assume a role that extends beyond the more traditional instructional role, and includes implied or explicit expectations to provide student advisees with…

Fostering Academic Self-Concept: Advisor Support and Sense of Belonging among International and Domestic Graduate Students

Science.gov (United States)

Curtin, Nicola; Stewart, Abigail J.; Ostrove, Joan M.

2013-01-01

International doctoral students in the United States face challenges of acculturation in academia yet complete graduate school at higher rates and more quickly than their domestic counterparts. This study examined advisor support, sense of belonging, and academic self-concept among international and domestic doctoral students at a research…

77 FR 49839 - IndexIQ Advisors LLC and IndexIQ Active ETF Trust; Notice of Application

Science.gov (United States)

2012-08-17

... Advisors LLC and IndexIQ Active ETF Trust; Notice of Application August 13, 2012. AGENCY: Securities and... IndexIQ Active ETF Trust (the ``Trust''). SUMMARY OF APPLICATION: Applicants request an order that... series, IQ Global Equity Active ETF (``Global Equity ETF''), IQ Global Fixed Income Active ETF (``Global...

BKR 27(2) pp. 98-105 (Ugbaja et al)

African Journals Online (AJOL)

Femi J. Olorunniji

2015-06-30

Jun 30, 2015 ... Vitamins C and E attenuate lipid dystrophy in tissues of rats administered .... weeks for acclimation prior to experimental treatment. The rats were ..... fluoride and aluminium in liver and gastrocnemium muscle of female mice.

Latino sexual and gender identity minorities promoting sexual health within their social networks: Process evaluation findings from a lay health advisor intervention

Science.gov (United States)

Sun, Christina J.; García, Manuel; Mann, Lilli; Alonzo, Jorge; Eng, Eugenia; Rhodes, Scott D.

2015-01-01

The HOLA intervention was a lay health advisor intervention designed to reduce the disproportionate HIV burden borne by Latino sexual and gender identity minorities (gay, bisexual, and other men who have sex with men, and transgender persons) living in the United States. Process evaluation data were collected for over a year of intervention implementation from 11 trained Latino male and transgender lay health advisors (Navegantes) to document the activities each Navegante conducted to promote condom use and HIV testing among his or her 8 social network members enrolled in the study. Over 13 months, the Navegantes reported conducting 1,820 activities. The most common activity was condom distribution. Navegantes had extensive reach beyond their enrolled social network members, and they engaged in health promotion activities beyond social network members enrolled in the study. There were significant differences between the types of activities conducted by Navegantes depending on who was present. Results suggest that lay health advisor interventions reach large number of at-risk community members and may benefit populations disproportionately impacted by HIV. PMID:25416309

Research on Gyrotrons.

Science.gov (United States)

1985-04-15

8217 ) (2N’n I roBo )2wL(I - I/vo)exptEo2(aw/w) 2/2j { 2(kp , /mor4) 2("-1t[ 0 2L~o2 ( A/,’w)/2 - n ](2 TQV) ’, (1) C mw)m, = [n + (n2 + 42 .,4)i2 I/ 2 2...Acknowledgement The author would like to express his gratitude to his advisor , Professor Jay L. Hirshfield, for the indefatigable scientific discussion which

Expression of c-Fos and c-Jun in the cornea, lens, and retina after ultraviolet irradiation of the rat eye and effect of topical antisense oligodeoxynucleotides

International Nuclear Information System (INIS)

Gillardon, F.; Zimmermann, M.

1995-01-01

Aims - Immunohistochemical techniques were used to investigate c-Fos and c-Jun proto-oncogene expression in the cornea, lens, and retina after ultraviolet irradiation of the rat eye. Methods -Eyes of anaesthetised rats were exposed to 1.5 J/cm 2 of ultraviolet radiation (280-380 nm). Animals were perfused 1, 6, or 24 hours after irradiation and tissue sections were incubated with specific antiserum to c-Fos and c-Jun, respectively. Non-irradiated contralateral eyes displayed no c-Fos and c-Jun immunoreactivity. One and 6 hours after ultraviolet exposure numerous c-Fos and c-Jun immunopositive nuclei were observed mainly in the epithelial cell layers of the cornea and the lens epithelium. Scattered labelled nuclei were detectable in the retinal ganglion cell layer and the inner nuclear layer. Twenty four hours after irradiation c-Fos and c-Jun protein expression returned to near control levels. Histological signs of ultraviolet damage (for example, chromatin condensation, nuclear fragmentation) were first recognisable in the corneal epithelium 6 hours after irradiation and became more apparent at later times. The rapid and sustained activation of c-Fos and c-Jun expression in the eye after single ultraviolet exposure may represent the molecular mechanism underlying ultraviolet induced photodamage and initiation of cell death. Furthermore, topical application of a c-fos antisense oligode-oxynucleotide to the ultraviolet exposed rat eye inhibited the increase in c-Fos expression in the cornea, suggesting therapeutic activity of antisense drugs in corneal malignant and infectious diseases. (author)

Installation and evaluation of a nuclear power plant operator advisor based on artificial intelligence technology

International Nuclear Information System (INIS)

Hajek, B.K.; Miller, D.W.

1989-01-01

This report discusses the following topics on a Nuclear Power Plant operator advisor based on artificial Intelligence Technology; Workstation conversion; Software Conversion; V ampersand V Program Development Development; Simulator Interface Development; Knowledge Base Expansion; Dynamic Testing; Database Conversion; Installation at the Perry Simulator; Evaluation of Operator Interaction; Design of Man-Machine Interface; and Design of Maintenance Facility

Bioenergy, Land Use Change and Climate Change Mitigation. Report for Policy Advisors and Policy Makers

Energy Technology Data Exchange (ETDEWEB)

Berndes, Goran [Chalmers Univ. of Technology (Sweden); Bird, Nell [Joanneum Research (Austria); Cowle, Annette [National Centre for Rural Greenhouse Gas Research (Australia)

2010-07-01

The report addresses a much debated issue - bioenergy and associated land use change, and how the climate change mitigation from use of bioenergy can be influenced by greenhouse gas emissions arising from land use change. The purpose of the report was to produce an unbiased, authoritative statement on this topic aimed especially at policy advisors and policy makers.

Strontium-90 and cesium-137 in sea fish (from Oct. 1981 to Jun. 1982)

International Nuclear Information System (INIS)

1982-01-01

Strontium-90 and cesium-137 in sea fishes (from Oct. 1981 to Jun. 1982) were determined. Fish was collected from eight sampling locations. Only the edible part was used in case of larger sized fish, and the whole part was used in case of smaller ones. The results are shown in a table. (Namekawa, K.)

SCIENTIFIC ARTICLES

African Journals Online (AJOL)

2018-06-01

Jun 1, 2018 ... Director of Monitoring, Evaluation, and Organizational Learning, Physicians for Peace, 500 E ... developed the Ségou region's first blood centre at HNF, with trained .... As is the case elsewhere in Africa, the financial burden imposed on .... Ségou, both Millennium Cities, and Markala, a smaller city in the.

Are Shorter Article Titles More Attractive for Citations? Cross-sectional Study of 22 Scientific Journals

Science.gov (United States)

Habibzadeh, Farrokh; Yadollahie, Mahboobeh

2010-01-01

Aim To investigate the correlation between the length of the title of a scientific article and the number of citations it receives, in view of the common editorial call for shorter titles. Methods Title and the number of citations to all articles published in 2005 in 22 arbitrarily chosen English-language journals (n = 9031) were retrieved from citation database Scopus. The 2008 journal impact factors of these 22 journals were also retrieved from Thomson Reuters’ Journal Citation Report (JCR). Assuming the article title length as the independent variable, and the number of citations to the article as the dependent variable, a linear regression model was applied. Results The slope of the regression line for some journals (n = 6, when titles were measured in characters but 7 when titles were measured in words) was negative – none was significantly different from 0. The overall slope for all journals was 0.140 (when titles were measured in characters) and 0.778 (when titles were measured in words), significantly different from 0 (P articles with longer titles received more citations – Spearman ρ = 0.266 – when titles were measured in characters, and ρ = 0.244 when titles were measured in words (P 10 and for 2 out of 14 journals with impact factor <10 (P < 0.001, Fisher exact test). Conclusion Longer titles seem to be associated with higher citation rates. This association is more pronounced for journals with high impact factors. Editors who insist on brief and concise titles should perhaps update the guidelines for authors of their journals and have more flexibility regarding the length of the title. PMID:20401960

Design and Operational Evaluation of the Traffic Management Advisor at the Fort Worth Air Route Traffic Control Center

Science.gov (United States)

1997-06-19

NASA and the Federal Aviation Administration (FAA) have designed and developed an automation tool known as the Traffic Management Advisor (TMA). The TMA is a time-based strategic planning tool that provides Traffic Management Coordinators (TMCs) and ...

77 FR 41464 - IndexIQ Advisors LLC and IndexIQ Active ETF Trust; Notice of Application

Science.gov (United States)

2012-07-13

...] IndexIQ Advisors LLC and IndexIQ Active ETF Trust; Notice of Application July 9, 2012. AGENCY... IndexIQ Active ETF Trust (``Trust''). Filing Dates: The application was filed on September 9, 2011, and... relief is unusual insofar as the requested order seeks relief for an ETF. Applicants note, however, that...

Panorama 98. 16 thematic files

International Nuclear Information System (INIS)

Anon.

1998-01-01

Under the 'Panorama 98' title, the Institut Francais du Petrole (IFP) has organized an international colloquium on the most recent events and the foreseeable perspectives in the domain of hydrocarbons. 16 technical and economical documentation files were given to the participants. This paper presents a synthesis of the content of these files: the oil offer and demand, the worldwide petroleum activity, the recent oil and gas discoveries, the stakes of the oil and gas perspectives in the North Sea, the US renewal in the Gulf of Mexico, the exploitation of heavy and extra-heavy crudes in Venezuela, the Asian oil rise, the limits of oil recovery efficiency, the oil markets, the international overview of the natural gas industry, the perspectives of the LNG market, the recent evolution and the perspectives of the European refining activities, the oil companies in 1997, the future of marketing, the trends of European automotive industry, and the scientific certitudes and uncertainties about urban pollution. (J.S.)

CERN Technical training: Available places in forthcoming courses

CERN Multimedia

HR Department

2010-01-01

The following course sessions are scheduled in the framework of the 2010 CERN Technical Training Programme and places are still available. You can find the full updated Technical Training course programme in our web catalogue. Software and system technologies C++ Part 2: Object-Oriented and Generic Programming\t25-MAY-10\t28-MAY-10\tEnglish\t3 days ITIL Foundations (version 3)\t31-MAY-10\t02-JUN-10\tEnglish\t3 days ITIL Foundations (version 3) EXAMINATION\t22-JUN-10\t22-JUN-10\tEnglish\t1 hour JAVA 2 Enterprise Edition - Part 2: Enterprise JavaBeans\t21-JUN-10\t23-JUN-10\tEnglish\t3 days JCOP - Finite State Machines in the JCOP Framework\t22-JUN-10\t24-JUN-10\tEnglish\t3 days JCOP - Joint PVSS-JCOP Framework\t31-MAY-10\t04-JUN-10\tEnglish\t4.5 days Le Langage C (ANSI et C99)\t24-JUN-10\t02-JUL-10\tEnglish\t4 days Object-oriented Design Patterns\t10-MAY-10\t12-MAY-10\tEnglish\t3 days Oracle - Programming with PL/SQL\t28-JUN-10\t30-JUN-10\tEnglish\t3 days Oracle Certified Professional\t07-JUN-10\t11-JUN-10\tEnglish\t5 days Project Development using ...

Effect of bisphosphonates on NFATc1 and correlators p-NF-κB and p-c-Jun in osteoclast differentiation

Directory of Open Access Journals (Sweden)

Wei DONG

2015-11-01

Full Text Available Objective　To study the effect of alendronate (ALN on NFATc1 and correlated signaling factors p-NF-κB and p-c-Jun in osteoclast differentiation. Methods　Osteoclasts were inductively cultivated with mouse mononuclear macrophage RAW264.7, and they were divided into 2 groups: group A (control group and group B (ALN-treated group. The protein expressions of NFATc1, p-NF-κB and p-c-Jun were determined with Western blotting at the 2nd day of cultivation; the expression of NFATc1 was assessed by immunofluorescent assay on the 4th day; and the osteoclast formation was examined on the 7th day of cultivation. RAW264.7 cells were inoculated on abrasive dentine disk, and divided into 2 groups and treated as mentioned above. The resorption function of osteoclast was observed on the 9th day of inoculation. Results　TRAP positive multinuclear osteoclasts were observed, and resorption lacunaes formed in the abrasive dentine disks of the 2 groups. More TRAP positive multinuclear cells and resorption lacunaes in large size were found in group A than those in group B. Immunofluorescence assay showed the expression of NFATc1 was higher in group A than in group B. The gene expressions of NFATc1, p-NF-κB and p-c-Jun were lower in group B than in group A(P<0.01 as determined with Western blotting. Conclusion　By down-regulating the expressions of p-NF-κB and p-c-Jun, ALN may strongly inhibit the osteoclast formation and its resorption function, thus inhibiting NFATc1 expression. DOI: 10.11855/j.issn.0577-7402.2015.10.02

Strontium-90 and cesium-137 in total diet (from Nov. 1982 to Jun. 1983)

International Nuclear Information System (INIS)

1983-01-01

Strontium-90 and cesium-137 in total diet (from Nov. 1982 to Jun. 1983) were determined. A full one day ordinary diet including three meals, water, tea and other in-between snacks for five persons was collected as a sample of ''total diet'' from 26 sampling locations. The results are shown in a table. (J.P.N.)

Strontium-90 and cesium-137 in sea fish (from Nov. 1982 to Jun. 1983)

International Nuclear Information System (INIS)

1983-01-01

Strontium-90 and cesium-137 in sea fish (from Nov. 1982 to Jun. 1983) were determined. Fishes were collected from eight sampling locations. Only the edible part was used in case of larger sized fish, and the whole part was used in case of smaller ones. The results are shown in a table. (J.P.N.)

Experience with the shift technical advisor position

International Nuclear Information System (INIS)

Melber, B.D.; Olson, J.; Schreiber, R.E.; Winges, L.

1984-03-01

The provision of engineering expertise on shift at commercial nuclear power plants has mainly taken the form of the Shift Technical Advisor (STA). This person, acting in a capacity that is part engineer and part operator, is expected to advise the operations crew in the event of an emergency and review plant operating experience during normal circumstances. The position was mandated by the Nuclear Regulatory Commission following the incident at Three Mile Island. This report expands on a growing body of knowledge regarding the effectiveness of the STA. The new data presented here come from interviews with plant personnel and utility officials from nine sites. Researchers from the Pacific Northwest Laboratory (PNL) interviewed plant personnel, including the STA and immediate management, the shift supervisor and management, the training department, and ancillary staff, all of whom affect the intended performance of the STA. The conclusions of the report are that the design of the STA position results in limited contribution during emergencies; more comprehensive ways should be sought to provide the variety and specificity of engineering expertise needed during such times

Experience with the shift technical advisor position

Energy Technology Data Exchange (ETDEWEB)

Melber, B.D.; Olson, J.; Schreiber, R.E.; Winges, L.

1984-03-01

The provision of engineering expertise on shift at commercial nuclear power plants has mainly taken the form of the Shift Technical Advisor (STA). This person, acting in a capacity that is part engineer and part operator, is expected to advise the operations crew in the event of an emergency and review plant operating experience during normal circumstances. The position was mandated by the Nuclear Regulatory Commission following the incident at Three Mile Island. This report expands on a growing body of knowledge regarding the effectiveness of the STA. The new data presented here come from interviews with plant personnel and utility officials from nine sites. Researchers from the Pacific Northwest Laboratory (PNL) interviewed plant personnel, including the STA and immediate management, the shift supervisor and management, the training department, and ancillary staff, all of whom affect the intended performance of the STA. The conclusions of the report are that the design of the STA position results in limited contribution during emergencies; more comprehensive ways should be sought to provide the variety and specificity of engineering expertise needed during such times.

Aplicación de la Agenda 21 en los Planes de Desarrollo Concertado de las provincias del departamento de Junín

Directory of Open Access Journals (Sweden)

Hugo Miguel Miguel

2015-06-01

Full Text Available Este trabajo de investigación ha tenido como objetivo comprobar la influencia de la Agenda 21 en los planes de desarrollo concertado de los gobiernos locales provinciales del departamento de Junín mediante la inclusión de los indicadores de desarrollo sostenible. Para su ejecución se utilizó el método de investigación descriptivo correlacional. Los instrumentos aplicados fueron fichas de observación de 25 ítems, en función de la estructura lógica de la Agenda 21, dentro de esta: las dimensiones del desarrollo sostenible (económico, social y ambiental. La población de estudio estuvo conformada por los planes de desarrollo concertado de las nueve provincias del departamento de Junín. De la misma forma, la muestra censal estuvo compuesta por los nueve planes de desarrollo concertado provinciales de la región Junín. Algunos de los resultados obtenidos revelan que la influencia de la Agenda 21 en los planes de desarrollo de los gobiernos locales provinciales del departamento de Junín, mediante la inclusión de sus indicadores de desarrollo sostenible (inclusión del 23 % del total de indicadores no fue significativa (p > 0,05, ya que la prueba binomial presenta un valor p de 1, mayor que el nivel usual de significación de 0,05. En conclusión la Agenda 21 que promueve el desarrollo y la cooperación en la esfera del medio ambiente, no influyó significativamente en los planes de desarrollo concertado de los gobiernos locales provinciales del departamento de Junín, porque solo se incluyeron el 23 % de los indicadores de desarrollo sostenible.

Perceptions of pre-clerkship medical students and academic advisors about sleep deprivation and its relationship to academic performance: a cross-sectional perspective from Saudi Arabia.

Science.gov (United States)

AlFakhri, Lama; Sarraj, Jumana; Kherallah, Shouq; Kuhail, Khulood; Obeidat, Akef; Abu-Zaid, Ahmed

2015-12-01

The medical student population is believed to be at an increased risk for sleep deprivation. Little is known about students' perceptions towards sleep deprivation and its relationship to academic performance. The aim of study is to explore the perceptions of medical students and their academic advisors about sleep deprivation and its relationship to academic performance. The study took place at Alfaisal University, College of Medicine, Riyadh, Saudi Arabia. An online, anonymous, cross-sectional, self-rating survey was administered to first-, third-year students and their academic advisors. Two-tailed Mann-Whitney U test was used to compare the mean 5-point Likert scale responses between students according to gender, academic year and cumulative grade point average (cGPA). A total of 259 students and 21 academic advisors participated in the survey (response rates: 70.6 and 84%, respectively). The vast majority of students agreed that sleep deprivation negatively affects academic performance (78.8%) and mood (78.4%). Around 62.2 and 73.7% of students agreed that the demanding medical curriculum and stress of final exams lead to sleep deprivation, respectively. While 36.7% of students voiced the need for incorporation of curricular separate courses about healthy sleep patterns into medical curriculum, a much greater proportion of students (45.9%) expressed interest in extracurricular activities about healthy sleep patterns. Interestingly, only 13.5% of students affirmed that they were counselled about sleep patterns and academic performance by their academic advisors. There were several statistically significant differences of means of students' perceptions according to gender, academic year and cGPA. Despite almost all academic advisors (95.5%) asserted the importance of sleep patterns to academic performance, none (0%) inquired about sleep patterns when counselling students. Nineteen academic advisors (90.5%) recommended incorporation of sleep patterns related

The Effects of Task Clarification, Feedback, and Goal Setting on Student Advisors' Office Behaviors and Customer Service

Science.gov (United States)

Tittelbach, Danielle; DeAngelis, Maureen; Sturmey, Peter; Alvero, Alicia M.

2007-01-01

This study evaluated the effects of feedback, task clarification and goal-setting on office behaviors and customer service of ten undergraduate participants that served as university advisors. A multiple baseline design was implemented across three target behaviors: client greeting, front-desk behaviors, and punctuality. During intervention the…

STS-98 U.S. Lab Destiny rests in Atlantis' payload bay

Science.gov (United States)

2001-01-01

KENNEDY SPACE CENTER, Fla. -- The U.S. Lab Destiny rests in the payload bay of Space Shuttle Atlantis before closure of the doors. A key element in the construction of the International Space Station, Destiny is 28 feet long and weighs 16 tons. Destiny will be attached to the Unity node on the ISS using the Shuttle'''s robot arm, seen here on the left side, with the help of an elbow camera attached to the arm (near the upper end of the lab in the photo). This research and command-and-control center is the most sophisticated and versatile space laboratory ever built. It will ultimately house a total of 23 experiment racks for crew support and scientific research. Destiny will fly on STS-98, the seventh construction flight to the ISS. Launch of STS-98 is scheduled for Jan. 19 at 2:11 a.m. EST.

Bygningers varmebehov 98, Bv98

DEFF Research Database (Denmark)

Bygningers energibehov og i SBI-anvisning 189 Småhuse. Programmet kan anvendes på pc under operativsystemet Microsoft Windows 95, Windows 98 og Windows NT 4.0, Servicepack 3 eller nyere. Pc-programmet er en revideret og moderniseret udgave af pc-programmet Bygningers Varmebehov, BV95, som SBI udgav i 1995....

Activations of c-fos/c-jun signaling are involved in the modulation of hypothalamic superoxide dismutase (SOD) and neuropeptide Y (NPY) gene expression in amphetamine-mediated appetite suppression

International Nuclear Information System (INIS)

Hsieh, Y.-S.; Yang, S.-F.; Chiou, H.-L.; Kuo, D.-Y.

2006-01-01

Amphetamine (AMPH) is known as an anorectic agent. The mechanism underlying the anorectic action of AMPH has been attributed to its inhibitory action on hypothalamic neuropeptide Y (NPY), an appetite stimulant in the brain. This study was aimed to examine the molecular mechanisms behind the anorectic effect of AMPH. Results showed that AMPH treatment decreased food intake, which was correlated with changes of NPY mRNA level, but increased c-fos, c-jun and superoxide dismutase (SOD) mRNA levels in hypothalamus. To determine if c-fos or c-jun was involved in the anorectic response of AMPH, infusions of antisense oligonucleotide into the brain were performed at 1 h before daily AMPH treatment in freely moving rats, and the results showed that c-fos or c-jun knockdown could block this anorectic response and restore NPY mRNA level. Moreover, c-fos or c-jun knockdown could partially block SOD mRNA level that might involve in the modulation of NPY gene expression. It was suggested that c-fos/c-jun signaling might involve in the central regulation of AMPH-mediated feeding suppression via the modulation of NPY gene expression

Take me where I want to go: Institutional prestige, advisor sponsorship, and academic career placement preferences.

Directory of Open Access Journals (Sweden)

Diogo L Pinheiro

Full Text Available Placement in prestigious research institutions for STEM (science, technology, engineering, and mathematics PhD recipients is generally considered to be optimal. Yet some doctoral recipients are not interested in intensive research careers and instead seek alternative careers, outside but also within academe (for example teaching positions in Liberal Arts Schools. Recent attention to non-academic pathways has expanded our understanding of alternative PhD careers. However, career preferences and placements are also nuanced along the academic pathway. Existing research on academic careers (mostly research-centric has found that certain factors have a significant impact on the prestige of both the institutional placement and the salary of PhD recipients. We understand less, however, about the functioning of career preferences and related placements outside of the top academic research institutions. Our work builds on prior studies of academic career placement to explore the impact that prestige of PhD-granting institution, advisor involvement, and cultural capital have on the extent to which STEM PhDs are placed in their preferred academic institution types. What determines whether an individual with a preference for research oriented institutions works at a Research Extensive university? Or whether an individual with a preference for teaching works at a Liberal Arts college? Using survey data from a nationally representative sample of faculty in biology, biochemistry, civil engineering and mathematics at four different Carnegie Classified institution types (Research Extensive, Research Intensive, Master's I & II, and Liberal Arts Colleges, we examine the relative weight of different individual and institutional characteristics on institutional type placement. We find that doctoral institutional prestige plays a significant role in matching individuals with their preferred institutional type, but that advisor involvement only has an impact on those

Take me where I want to go: Institutional prestige, advisor sponsorship, and academic career placement preferences.

Science.gov (United States)

Pinheiro, Diogo L; Melkers, Julia; Newton, Sunni

2017-01-01

Placement in prestigious research institutions for STEM (science, technology, engineering, and mathematics) PhD recipients is generally considered to be optimal. Yet some doctoral recipients are not interested in intensive research careers and instead seek alternative careers, outside but also within academe (for example teaching positions in Liberal Arts Schools). Recent attention to non-academic pathways has expanded our understanding of alternative PhD careers. However, career preferences and placements are also nuanced along the academic pathway. Existing research on academic careers (mostly research-centric) has found that certain factors have a significant impact on the prestige of both the institutional placement and the salary of PhD recipients. We understand less, however, about the functioning of career preferences and related placements outside of the top academic research institutions. Our work builds on prior studies of academic career placement to explore the impact that prestige of PhD-granting institution, advisor involvement, and cultural capital have on the extent to which STEM PhDs are placed in their preferred academic institution types. What determines whether an individual with a preference for research oriented institutions works at a Research Extensive university? Or whether an individual with a preference for teaching works at a Liberal Arts college? Using survey data from a nationally representative sample of faculty in biology, biochemistry, civil engineering and mathematics at four different Carnegie Classified institution types (Research Extensive, Research Intensive, Master's I & II, and Liberal Arts Colleges), we examine the relative weight of different individual and institutional characteristics on institutional type placement. We find that doctoral institutional prestige plays a significant role in matching individuals with their preferred institutional type, but that advisor involvement only has an impact on those with a

Reference Value Advisor: a new freeware set of macroinstructions to calculate reference intervals with Microsoft Excel.

Science.gov (United States)

Geffré, Anne; Concordet, Didier; Braun, Jean-Pierre; Trumel, Catherine

2011-03-01

International recommendations for determination of reference intervals have been recently updated, especially for small reference sample groups, and use of the robust method and Box-Cox transformation is now recommended. Unfortunately, these methods are not included in most software programs used for data analysis by clinical laboratories. We have created a set of macroinstructions, named Reference Value Advisor, for use in Microsoft Excel to calculate reference limits applying different methods. For any series of data, Reference Value Advisor calculates reference limits (with 90% confidence intervals [CI]) using a nonparametric method when n≥40 and by parametric and robust methods from native and Box-Cox transformed values; tests normality of distributions using the Anderson-Darling test and outliers using Tukey and Dixon-Reed tests; displays the distribution of values in dot plots and histograms and constructs Q-Q plots for visual inspection of normality; and provides minimal guidelines in the form of comments based on international recommendations. The critical steps in determination of reference intervals are correct selection of as many reference individuals as possible and analysis of specimens in controlled preanalytical and analytical conditions. Computing tools cannot compensate for flaws in selection and size of the reference sample group and handling and analysis of samples. However, if those steps are performed properly, Reference Value Advisor, available as freeware at http://www.biostat.envt.fr/spip/spip.php?article63, permits rapid assessment and comparison of results calculated using different methods, including currently unavailable methods. This allows for selection of the most appropriate method, especially as the program provides the CI of limits. It should be useful in veterinary clinical pathology when only small reference sample groups are available. ©2011 American Society for Veterinary Clinical Pathology.

A Workflow-based Intelligent Network Data Movement Advisor with End-to-end Performance Optimization

Energy Technology Data Exchange (ETDEWEB)

Zhu, Michelle M. [Southern Illinois Univ., Carbondale, IL (United States); Wu, Chase Q. [Univ. of Memphis, TN (United States)

2013-11-07

Next-generation eScience applications often generate large amounts of simulation, experimental, or observational data that must be shared and managed by collaborative organizations. Advanced networking technologies and services have been rapidly developed and deployed to facilitate such massive data transfer. However, these technologies and services have not been fully utilized mainly because their use typically requires significant domain knowledge and in many cases application users are even not aware of their existence. By leveraging the functionalities of an existing Network-Aware Data Movement Advisor (NADMA) utility, we propose a new Workflow-based Intelligent Network Data Movement Advisor (WINDMA) with end-to-end performance optimization for this DOE funded project. This WINDMA system integrates three major components: resource discovery, data movement, and status monitoring, and supports the sharing of common data movement workflows through account and database management. This system provides a web interface and interacts with existing data/space management and discovery services such as Storage Resource Management, transport methods such as GridFTP and GlobusOnline, and network resource provisioning brokers such as ION and OSCARS. We demonstrate the efficacy of the proposed transport-support workflow system in several use cases based on its implementation and deployment in DOE wide-area networks.

Recent Updates to the System Advisor Model (SAM)

Energy Technology Data Exchange (ETDEWEB)

DiOrio, Nicholas A [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

2018-02-14

The System Advisor Model (SAM) is a mature suite of techno-economic models for many renewable energy technologies that can be downloaded for free as a desktop application or software development kit. SAM is used for system-level modeling, including generating performance pro the release of the code as an open source project on GitHub. Other additions that will be covered include the ability to download data directly into SAM from the National Solar Radiation Database (NSRDB) and up- dates to a user-interface macro that assists with PV system sizing. A brief update on SAM's battery model and its integration with the detailed photovoltaic model will also be discussed. Finally, an outline of planned work for the next year will be presented, including the addition of a bifacial model, support for multiple MPPT inputs for detailed inverter modeling, and the addition of a model for inverter thermal behavior.

Resident Advisor General Intelligence, Emotional Intelligence, Personality Dimensions, and Internal Belief Characteristics as Predictors of Rated Performance

Science.gov (United States)

Wu, Max B.; Stemler, Steven

2008-01-01

Resident Advisors (RAs) have a significant hand in helping students adjust and thrive in college life. Given the importance of selecting high-performing RAs, this study sought to examine how well various measures of intelligence (e.g., general, emotional) in addition to personality and additional "internal belief" characteristics predict…

75 FR 13264 - Meeting of the Board of Advisors (BOA) to the President, Naval Postgraduate School (NPS)

Science.gov (United States)

2010-03-19

... DEPARTMENT OF DEFENSE Department of the Navy Meeting of the Board of Advisors (BOA) to the President, Naval Postgraduate School (NPS) AGENCY: Department of the Navy, DoD. ACTION: Notice of open... access, information, or to send written comments regarding the NPS BOA, contact Ms. Jaye Panza, Naval...

Pinwheel Nebula around WR 98a.

Science.gov (United States)

Monnier; Tuthill; Danchi

1999-11-10

We present the first near-infrared images of the dusty Wolf-Rayet star WR 98a. Aperture-masking interferometry has been utilized to recover images at the diffraction limit of the Keck I telescope, less, similar50 mas at 2.2 µm. Multiepoch observations spanning about 1 yr have resolved the dust shell into a "pinwheel" nebula, the second example of a new class of dust shell first discovered around WR 104 by Tuthill, Monnier, & Danchi. Interpreting the collimated dust outflow in terms of an interacting winds model, the binary orbital parameters and apparent wind speed are derived: a period of 565+/-50 days, a viewing angle of 35&j0;+/-6 degrees from the pole, and a wind speed of 99+/-23 mas yr-1. This period is consistent with a possible approximately 588 day periodicity in the infrared light curve, linking the photometric variation to the binary orbit. Important implications for binary stellar evolution are discussed by identifying WR 104 and WR 98a as members of a class of massive, short-period binaries whose orbits were circularized during a previous red supergiant phase. The current component separation in each system is similar to the diameter of a red supergiant, which indicates that the supergiant phase was likely terminated by Roche lobe overflow, leading to the present Wolf-Rayet stage.

Knowledge Sharing Among Tourists via Social Media: A Comparison Between Facebook and TripAdvisor

OpenAIRE

Okazaki Ono, Shintaro; Andreu, Luisa; Campo, Sara

2016-01-01

This paper examines tourists’ knowledge sharing behavior in social media. Based on social capital theory, we aim to examine the effects of three dimensions of social capital—structural (social interaction ties), cognitive (shared vision), and relational (trust)—for two different types of social media: Facebook and TripAdvisor. We propose a structural model that connects an antecedent (homophily) and a consequence (knowledge sharing through posting) of these main dimensions of social capital. ...

Pregnane and Xenobiotic Receptor gene expression in liver cells is modulated by Ets-1 in synchrony with transcription factors Pax5, LEF-1 and c-jun

Energy Technology Data Exchange (ETDEWEB)

Kumari, Sangeeta; Saradhi, Mallampati; Rana, Manjul; Chatterjee, Swagata [Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067 (India); Aumercier, Marc [IRI, CNRS USR 3078, Université de Lille-Nord de France, Parc CNRS de la Haute Borne, 50 Avenue de Halley, BP 70478, 59658 Villeneuve d’Ascq Cedex (France); Mukhopadhyay, Gauranga [Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067 (India); Tyagi, Rakesh K., E-mail: rktyagi@yahoo.com [Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067 (India)

2015-01-15

Nuclear receptor PXR is predominantly expressed in liver and intestine. Expression of PXR is observed to be dysregulated in various metabolic disorders indicating its involvement in disease development. However, information available on mechanisms of PXR self-regulation is fragmentary. The present investigation identifies some of the regulatory elements responsible for its tight regulation and low cellular expression. Here, we report that the PXR-promoter is a target for some key transcription factors like PU.1/Ets-1, Pax5, LEF-1 and c-Jun. Interestingly, we observed that PXR-promoter responsiveness to Pax5, LEF-1 and c-Jun, is considerably enhanced by Ets transcription factors (PU.1 and Ets-1). Co-transfection of cells with Ets-1, LEF-1 and c-Jun increased PXR-promoter activity by 5-fold and also induced expression of endogenous human PXR. Site-directed mutagenesis and transfection studies revealed that two Ets binding sites and two of the three LEF binding sites in the PXR-promoter are functional and have a positive effect on PXR transcription. Results suggest that expression of Ets family members, in conjunction with Pax5, LEF-1 and c-Jun, lead to coordinated up-regulation of PXR gene transcription. Insights obtained on the regulation of PXR gene have relevance in offering important cues towards normal functioning as well as development of several metabolic disorders via PXR signaling. - Highlights: • The study identified cis-regulatory elements in the nuclear receptor PXR promoter. • Several trans-acting factors modulating the PXR-promoter have been identified. • PU.1/Ets-1, Pax5, LEF-1, c-Jun, LyF-VI and NF-1 act as modulators of the PXR-promoter. • Ets-1 in conjunction with LEF-1 and c-Jun exhibit 5-fold activation of the PXR-promoter. • Insights into PXR-regulation have relevance in normal and pathological conditions.

Valoración económica del almacenamiento de agua y carbono en la comunidad campesina Villa de Junín

Directory of Open Access Journals (Sweden)

Miguel Vila Balbin

2015-12-01

Full Text Available El objetivo ha sido estimar el valor económico que generan los bofedales en el almacenamiento de agua y carbono en la comunidad campesina Villa de Junín en el departamento de Junín, Perú. El proceso de recolección de datos a estado enfocado en datos meteorológicos (temperatura y precipitación, datos de la actividad económica predominante (ganadería, recolección de muestras de suelo para hallar el contenido de carbono y capacidad volumétrica; posteriormente se hizo la comparación del beneficio percibido por la actividad ganadera y el beneficio que se podría obtener por los servicios que brinda un bofedal (almacenamiento de agua y carbono. Entre los resultados respecto a la precipitación anual se ha determinado 22 367 664 m3/año, del cual un 42,56 % (9 294 933,67 m3/ año regresa a la atmósfera a través del proceso de la evapotranspiración, quedando una oferta hídrica disponible de 13 072 730,33 m3/año, que representa un 57,44 % de la oferta hídrica total; la productividad hídrica es de 0,01 S/./m3. El costo de oportunidad que tiene la ganadería es de 200,38 S/./ha /año; el valor económico de agua y carbono es de S/. 48 974 181,79 y S/. 44 305 010,31 respectivamente. Se concluye que el almacenamiento de agua y carbono brindan mayores ingresos económicos a la población que la actividad ganadera.

Academic involvement in shift technical advisor training for the utilities

International Nuclear Information System (INIS)

Davidson, J.N.; Sain, L.H.

1981-01-01

One of the clearest conclusions reached of nearly every commission and panel formed in response to the Three Mile Island accident was the desirability of upgrading the educational background of those persons with direct operational responsibility in a nuclear power plant. The long term objective is for all shift supervisors to have engineering degrees as well as NRC senior operating licenses. In the interim, the utilities are required to provide in-depth engineering expertise on every shift in the person of a Shift Technical Advisor (STA). The training of STA's is complicated by the requirement to have college level instruction in plant specific topics which are not typically included in the curricula of degree-granting instructions. One possible response to this challenge is presented

C/EBPβ LIP and c-Jun synergize to regulate expression of the murine progesterone receptor.

Science.gov (United States)

Wang, Weizhong; Do, Han Ngoc; Aupperlee, Mark D; Durairaj, Srinivasan; Flynn, Emily E; Miksicek, Richard J; Haslam, Sandra Z; Schwartz, Richard C

2018-06-02

CCAAT/enhancer binding protein β (C/EBPβ) is required for murine mammary ductal morphogenesis and alveologenesis. Progesterone is critical for proliferation and alveologenesis in adult mammary glands, and there is a similar requirement for progesterone receptor isoform B (PRB) in alveologenesis. We examined C/EBPβ regulation of PR expression. All three C/EBPβ isoforms, including typically inhibitory LIP, transactivated the PR promoter. LIP, particularly, strongly synergized with c-Jun to drive PR transcription. Endogenous C/EBPβ and c-Jun stimulated a PR promoter-reporter and these two factors showed promoter occupancy on the endogenous PR gene. Additionally, LIP overexpression elevated endogenous PR protein expression. In pregnancy, both PRB and the relative abundance of LIP among C/EBPβ isoforms increase. Consistent with a role in PRB expression, in vivo C/EBPβ and PR isoform A expression showed mutually exclusive localization in mammary epithelium, while C/EBPβ and PRB largely co-localized. We suggest a critical role for C/EBPβ, particularly LIP, in PRB expression. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

CERN Technical training: Available places in forthcoming courses

CERN Multimedia

HR Department

2010-01-01

The following course sessions are scheduled in the framework of the 2010 CERN Technical Training Programme and places are still available. You can find the full updated Technical Training course programme in our web catalogue. Software and system technologies C++ Part 2: Object-Oriented and Generic Programming\t25-MAY-10\t28-MAY-10\tEnglish\t3 days Certification: Ingénieur en Sécurité Fonctionnelle\t07-JUN-10\t10-JUN-10\tFrench\t4 jours Emacs - way beyond Text Editing\t16-JUL-10\t16-JUL-10\tEnglish\t1 day ITIL Foundations (version 3)\t31-MAY-10\t02-JUN-10\tEnglish\t3 days ITIL Foundations (version 3) EXAMINATION\t22-JUN-10\t22-JUN-10\tEnglish\t1 hour JAVA - Level 2\t05-JUL-10\t08-JUL-10\tEnglish\t4 days JAVA 2 Enterprise Edition - Part 2: Enterprise JavaBeans\t21-JUN-10\t23-JUN-10\tEnglish\t3 days JCOP - Finite State Machines in the JCOP Framework\t22-JUN-10\t24-JUN-10\tEnglish\t3 days JCOP - Joint PVSS-JCOP Framework\t31-MAY-10\t04-JUN-10\tEnglish\t4.5 days Le Langage C (ANSI et C99)\t24-JUN-10\t02-JUL-10\tEnglis...

CERN Technical training: Available places in forthcoming courses

CERN Multimedia

HR Department

2010-01-01

The following course sessions are scheduled in the framework of the 2010 CERN Technical Training Programme and places are still available. You can find the full updated Technical Training course programme in our web catalogue. Software and system technologies C++ Part 2: Object-Oriented and Generic Programming\t25-MAY-10\t28-MAY-10\tEnglish\t3 days Certification: Ingénieur en Sécurité Fonctionnelle\t07-JUN-10\t10-JUN-10\tFrench\t3.5 jours Emacs - way beyond Text Editing\t16-JUL-10\t16-JUL-10\tEnglish\t1 day ITIL Foundations (version 3)\t31-MAY-10\t02-JUN-10\tEnglish\t3 days ITIL Foundations (version 3) EXAMINATION\t22-JUN-10\t22-JUN-10\tEnglish\t1 hour JAVA - Level 2\t05-JUL-10\t08-JUL-10\tEnglish\t4 days JAVA 2 Enterprise Edition - Part 2: Enterprise JavaBeans\t21-JUN-10\t23-JUN-10\tEnglish\t3 days JCOP - Finite State Machines in the JCOP Framework\t22-JUN-10\t24-JUN-10\tEnglish\t3 days JCOP - Joint PVSS-JCOP Framework\t31-MAY-10\t04-JUN-10\tEnglish\t4.5 days Le Langage C (ANSI et C99)\t24-JUN-10\t02-JUL-10\tEngl...

c-Jun/AP-1 pathway-mediated cyclin D1 expression participates in low dose arsenite-induced transformation in mouse epidermal JB6 Cl41 cells

International Nuclear Information System (INIS)

Zhang Dongyun; Li Jingxia; Gao Jimin; Huang Chuanshu

2009-01-01

Arsenic is a well-documented human carcinogen associated with skin carcinogenesis. Our previous work reveals that arsenite exposure is able to induce cell transformation in mouse epidermal cell JB6 Cl41 through the activation of ERK, rather than JNK pathway. Our current studies further evaluate downstream pathway in low dose arsenite-induced cell transformation in JB6 Cl41 cells. Our results showed that treatment of cells with low dose arsenite induced activation of c-Jun/AP-1 pathway, and ectopic expression of dominant negative mutant of c-Jun (TAM67) blocked arsenite-induced transformation. Furthermore, our data indicated that cyclin D1 was an important downstream molecule involved in c-Jun/AP-1-mediated cell transformation upon low dose arsenite exposure, because inhibition of cyclin D1 expression by its specific siRNA in the JB6 Cl41 cells resulted in impairment of anchorage-independent growth of cells induced by low dose arsenite. Collectively, our results demonstrate that c-Jun/AP-1-mediated cyclin D1 expression is at least one of the key events implicated in cell transformation upon low dose arsenite exposure

ENC 98

International Nuclear Information System (INIS)

1998-01-01

This press dossier document reports on the main points presented by the Framatome group at the ENC'98 colloquium which took place in Nice (France) on September 25 1998. The summary comprises 4 main parts: the 1997-98 highlights (nuclear realizations in France, China and Turkey, nuclear services, nuclear fuels), the international activities in the nuclear domain (USA, China, Eastern Europe), the research and development activities (the French-German joint EPR project, the high temperature reactor (HTR) project), and the service and nuclear fuel activities (maintenance, improvements, control and expertise). (J.S.)

75 FR 61806 - Self-Regulatory Organizations; Municipal Securities Rulemaking Board; Notice of Filing of...

Science.gov (United States)

2010-10-06

... under MSRB Rule A-3(i), to allow the Nominating Committee to solicit nominations for municipal advisor... Independent Public Finance Advisors, dated September 22, 2010 (``NAIPFA Letter''); letter from Michael Decker... No. 1, to address concerns raised by commenters, MSRB proposes that advisor representatives (as...

Medical Entomology Project.

Science.gov (United States)

1984-01-01

Manion, Anne G. 08 MAR 76 - 01 JUN 76 Markowitz, Norman L. 01 JUN 75 - 22 MAY 76 Munro, Susan Gale 21 OCT 79 - 31 DEC 82 Page, Ellen M. 29 OCT 74 - 26...Sunthorn, Dr. 01 JUN 74 - 30 JUN 80 Smallwood , Penelope B. 01 JUN 74 - 30 JUN 80 *Entomologist 29 SV Sohn, Young T. 01 JUN 7)4 - 31 JAN 81 Spangler

NCBI nr-aa BLAST: CBRC-TNIG-22-0185 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-TNIG-22-0185 ref|NP_103831.1| putative manganese transport protein MntH [Mesor...hizobium loti MAFF303099] sp|Q98I99|MNTH_RHILO Probable manganese transport protein mntH dbj|BAB49617.1| manga

Multi-Center Traffic Management Advisor Operational Field Test Results

Science.gov (United States)

Farley, Todd; Landry, Steven J.; Hoang, Ty; Nickelson, Monicarol; Levin, Kerry M.; Rowe, Dennis W.

2005-01-01

The Multi-Center Traffic Management Advisor (McTMA) is a research prototype system which seeks to bring time-based metering into the mainstream of air traffic control (ATC) operations. Time-based metering is an efficient alternative to traditional air traffic management techniques such as distance-based spacing (miles-in-trail spacing) and managed arrival reservoirs (airborne holding). While time-based metering has demonstrated significant benefit in terms of arrival throughput and arrival delay, its use to date has been limited to arrival operations at just nine airports nationally. Wide-scale adoption of time-based metering has been hampered, in part, by the limited scalability of metering automation. In order to realize the full spectrum of efficiency benefits possible with time-based metering, a much more modular, scalable time-based metering capability is required. With its distributed metering architecture, multi-center TMA offers such a capability.

The Honors Thesis: A Handbook for Honors Directors, Deans, and Faculty Advisors. National Collegiate Honors Council Monograph Series

Science.gov (United States)

Anderson, Mark; Lyons, Karen; Weiner, Norman

2014-01-01

This handbook is intended to help all those who design, administer, and implement honors thesis programs--honors directors, deans, staff, faculty, and advisors--evaluate their thesis programs, solve pressing problems, select more effective requirements or procedures, or introduce an entirely new thesis program. The authors' goal is to provide…

Lab notebooks as scientific communication: Investigating development from undergraduate courses to graduate research

Directory of Open Access Journals (Sweden)

Jacob T. Stanley

2016-09-01

Full Text Available In experimental physics, lab notebooks play an essential role in the research process. For all of the ubiquity of lab notebooks, little formal attention has been paid to addressing what is considered “best practice” for scientific documentation and how researchers come to learn these practices in experimental physics. Using interviews with practicing researchers, namely, physics graduate students, we explore the different experiences researchers had in learning how to effectively use a notebook for scientific documentation. We find that very few of those interviewed thought that their undergraduate lab classes successfully taught them the benefit of maintaining a lab notebook. Most described training in lab notebook use as either ineffective or outright missing from their undergraduate lab course experience. Furthermore, a large majority of those interviewed explained that they did not receive any formal training in maintaining a lab notebook during their graduate school experience and received little to no feedback from their advisors on these records. Many of the interviewees describe learning the purpose of, and how to maintain, these kinds of lab records only after having a period of trial and error, having already started doing research in their graduate program. Despite the central role of scientific documentation in the research enterprise, these physics graduate students did not gain skills in documentation through formal instruction, but rather through informal hands-on practice.

40 CFR 98.418 - Definitions.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Definitions. 98.418 Section 98.418 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Suppliers of Industrial Greenhouse Gases § 98.418 Definitions. All terms used in...

Oxytocin facilitation of acceptance of social advice is dependent upon the perceived trustworthiness of individual advisors.

Science.gov (United States)

Luo, Ruixue; Xu, Lei; Zhao, Weihua; Ma, Xiaole; Xu, Xiaolei; Kou, Juan; Gao, Zhao; Becker, Benjamin; Kendrick, Keith M

2017-09-01

The neuropeptide oxytocin may increase social cohesion by making us more willing to trust others and/or to conform to their opinions. Here we investigated whether intranasal oxytocin can influence acceptance of advice given on solving everyday social problems by either individual expert (psychologist) or non-expert advisors with or without influencing their perceived likeability or trustworthiness. In a double-blind, between-subject, placebo-control design study in 160 male and female subjects, intranasal oxytocin (24IU) only significantly enhanced acceptance of advice given by female psychologists who were rated as the most trustworthy advisors. However, oxytocin itself did not alter either trustworthiness or likeability ratings. The oxytocin effect on acceptance of the female psychologist's advice was not maintained after a week, with subjects mainly reverting to their original solutions. These findings suggest that while oxytocin can transiently increase acceptance of advice from the most trustworthy individuals this is because it makes subjects more likely to conform to their opinions rather than enhancing their perceived trustworthiness or likeability. Thus in every day contexts oxytocin may primarily promote social cohesion by facilitating conformity towards the opinions of the most trusted individuals. Copyright © 2017. Published by Elsevier Ltd.

Installation and evaluation of a nuclear power plant Operator Advisor based on artificial intelligence technology

International Nuclear Information System (INIS)

Hajek, B.K.; Miller, D.W.

1993-02-01

The Artificial Intelligence Group in the Nuclear Engineering Program has designed and built an Operator Advisor (OA), an AI system to monitor nuclear power plant parameters, detect component and system malfunctions, dispose their causes, and provide the plant operators with the correct procedures for mitigating the consequences of the malfunctions. It then monitors performance of the procedures, and provides backup steps when specific operator actions fail. The OA has been implemented on Sun 4 workstations in Common Lisp, and has been interfaced to run in real time on the Perry Nuclear Power Plant full-function simulator in the plant training department. The eventual goal for a fully functioning Operator Advisor would be to have reactor operators receive direction for all plant operations. Such a goal requires considerable testing of the system within limited malfunction boundaries, an extensive Verification ampersand Validation (V ampersand V) effort, a large knowledge base development effort, and development of tools as part of the system to automate its maintenance. Clearly, these efforts are beyond the scope of the feasibility effort expended during this project period. However, as a result of this project, we have an AI based platform upon which a complete system can be built

Reactive oxygen species activate differentiation gene transcription of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway.

Science.gov (United States)

Lam, Chung Fan; Yeung, Hoi Ting; Lam, Yuk Man; Ng, Ray Kit

2018-05-01

Reactive oxygen species (ROS) and altered cellular redox status are associated with many malignancies. Acute myeloid leukemia (AML) cells are maintained at immature state by differentiation blockade, which involves deregulation of transcription factors in myeloid differentiation. AML cells can be induced to differentiate by phorbol-12-myristate-13-acetate (PMA), which possesses pro-oxidative activity. However, the signaling events mediated by ROS in the activation of transcriptional program during AML differentiation has not been fully elucidated. Here, we investigated AML cell differentiation by treatment with PMA and ROS scavenger N-acetyl-l-cysteine (NAC). We observed elevation of intracellular ROS level in the PMA-treated AML cells, which correlated with differentiated cell morphology and increased CD11b + mature cell population. The effect of PMA can be abolished by NAC co-treatment, supporting the involvement of ROS in the process. Moreover, we demonstrated that short ROS elevation mediated cell cycle arrest, but failed to activate myeloid gene transcription; whereas prolonged ROS elevation activated JNK/c-JUN signaling pathway. Inhibition of JNK suppressed the expression of key myeloid transcriptional regulators c-JUN, SPI-1 and MAFB, and prevented AML cells from undergoing terminal differentiation. These findings provide new insights into the crucial role of JNK/c-Jun signaling pathway in the activation of transcriptional program during ROS-mediated AML differentiation. Copyright © 2018 Elsevier Ltd. All rights reserved.

PTT Advisor: A CDC-supported initiative to develop a mobile clinical laboratory decision support application for the iOS platform.

Science.gov (United States)

Savel, Thomas G; Lee, Brian A; Ledbetter, Greg; Brown, Sara; Lavalley, Dale; Taylor, Julie; Thompson, Pam

2013-01-01

This manuscript describes the development of PTT (Partial Thromboplastin Time) Advisor, one of the first of a handful of iOS-based mobile applications to be released by the US Centers for Disease Control and Prevention (CDC). PTT Advisor has been a collaboration between two groups at CDC (Informatics R&D and Laboratory Science), and one partner team (Clinical Laboratory Integration into Healthcare Collaborative - CLIHC). The application offers clinicians a resource to quickly select the appropriate follow-up tests to evaluate patients with a prolonged PTT and a normal Prothrombin Time (PT) laboratory result. The application was designed leveraging an agile methodology, and best practices in user experience (UX) design and mobile application development. As it is an open-source project, the code to PTT Advisor was made available to the public under the Apache Software License. On July 6, 2012, the free app was approved by Apple, and was published to their App Store. Regardless of the complexity of the mobile application, the level of effort required in the development process should not be underestimated. There are several issues that make designing the UI for a mobile phone challenging (not just small screen size): the touchscreen, users' mobile mindset (tasks need to be quick and focused), and the fact that mobile UI conventions/expectations are still being defined and refined (due to the maturity level of the field of mobile application development).

The activation of p38 MAPK primarily contributes to UV-induced RhoB expression by recruiting the c-Jun and p300 to the distal CCAAT box of the RhoB promoter

International Nuclear Information System (INIS)

Ahn, Jiwon; Choi, Jeong-Hae; Won, Misun; Kang, Chang-Mo; Gyun, Mi-Rang; Park, Hee-Moon; Kim, Chun-Ho; Chung, Kyung-Sook

2011-01-01

Highlights: → Regulation of transcriptional activation of RhoB is still unclear. → We examine the effect of p38 MAPK inhibition, and c-Jun and RhoB depletion on UV-induced RhoB expression and apoptosis. → We identify the regions of RhoB promoter necessary to confer UV responsiveness using pRhoB-luciferase reporter assays. → c-Jun, ATF2 and p300 are dominantly associated with NF-Y on the distal CCAAT box. → The activation of p38 MAPK primarily contribute to UV-induced RhoB expression by recruiting the c-Jun and p300 proteins on distal CCAAT box of RhoB promoter. -- Abstract: The Ras-related small GTP-binding protein RhoB is rapidly induced in response to genotoxic stresses caused by ionizing radiation. It is known that UV-induced RhoB expression results from the binding of activating transcription factor 2 (ATF2) via NF-Y to the inverted CCAAT box (-23) of the RhoB promoter. Here, we show that the association of c-Jun with the distal CCAAT box (-72) is primarily involved in UV-induced RhoB expression and p38 MAPK regulated RhoB induction through the distal CCAAT box. UV-induced RhoB expression and apoptosis were markedly attenuated by pretreatment with the p38 MAPK inhibitor. siRNA knockdown of RhoB, ATF2 and c-Jun resulted in decreased RhoB expression and eventually restored the growth of UV-irradiated Jurkat cells. In the reporter assay using luciferase under the RhoB promoter, inhibition of RhoB promoter activity by the p38 inhibitor and knockdown of c-Jun using siRNA occurred through the distal CCAAT box. Immunoprecipitation and DNA affinity protein binding assays revealed the association of c-Jun and p300 via NF-YA and the dissociation of histone deacetylase 1 (HDAC1) via c-Jun recruitment to the CCAAT boxes of the RhoB promoter. These results suggest that the activation of p38 MAPK primarily contributes to UV-induced RhoB expression by recruiting the c-Jun and p300 proteins to the distal CCAAT box of the RhoB promoter in Jurkat cells.

45 CFR 98.90 - Monitoring.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Monitoring. 98.90 Section 98.90 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CHILD CARE AND DEVELOPMENT FUND Monitoring, Non-compliance and Complaints § 98.90 Monitoring. (a) The Secretary will monitor programs funded under...

29 CFR 98.1000 - Respondent.

Science.gov (United States)

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Respondent. 98.1000 Section 98.1000 Labor Office of the Secretary of Labor GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Definitions § 98.1000 Respondent. Respondent means a person against whom an agency has initiated a debarment or suspension action. ...

34 CFR 98.6 - Reports.

Science.gov (United States)

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Reports. 98.6 Section 98.6 Education Office of the Secretary, Department of Education STUDENT RIGHTS IN RESEARCH, EXPERIMENTAL PROGRAMS, AND TESTING § 98.6 Reports. The Secretary may require the recipient to submit reports containing information necessary to...

50 CFR 22.21 - What are the requirements concerning scientific and exhibition purpose permits?

Science.gov (United States)

2010-10-01

... purposes? (1) You must submit applications for permits to take, possess, or transport within the United... golden eagles, or their parts, nests, or eggs for the scientific or exhibition purposes of public museums, public scientific societies, or public zoological parks. We will not issue a permit under this section...

The leucine zipper domains of the transcription factors GCN4 and c-Jun have ribonuclease activity.

Directory of Open Access Journals (Sweden)

Yaroslav Nikolaev

Full Text Available Basic-region leucine zipper (bZIP proteins are one of the largest transcription factor families that regulate a wide range of cellular functions. Owing to the stability of their coiled coil structure leucine zipper (LZ domains of bZIP factors are widely employed as dimerization motifs in protein engineering studies. In the course of one such study, the X-ray structure of the retro-version of the LZ moiety of yeast transcriptional activator GCN4 suggested that this retro-LZ may have ribonuclease activity. Here we show that not only the retro-LZ but also the authentic LZ of GCN4 has weak but distinct ribonuclease activity. The observed cleavage of RNA is unspecific, it is not suppressed by the ribonuclease A inhibitor RNasin and involves the breakage of 3',5'-phosphodiester bonds with formation of 2',3'-cyclic phosphates as the final products as demonstrated by HPLC/electrospray ionization mass spectrometry. Several mutants of the GCN4 leucine zipper are catalytically inactive, providing important negative controls and unequivocally associating the enzymatic activity with the peptide under study. The leucine zipper moiety of the human factor c-Jun as well as the entire c-Jun protein are also shown to catalyze degradation of RNA. The presented data, which was obtained in the test-tube experiments, adds GCN4 and c-Jun to the pool of proteins with multiple functions (also known as moonlighting proteins. If expressed in vivo, the endoribonuclease activity of these bZIP-containing factors may represent a direct coupling between transcription activation and controlled RNA turnover. As an additional result of this work, the retro-leucine zipper of GCN4 can be added to the list of functional retro-peptides.

9 CFR 98.30 - Definitions.

Science.gov (United States)

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Definitions. 98.30 Section 98.30... EMBRYOS AND ANIMAL SEMEN Certain Animal Semen § 98.30 Definitions. Whenever in this subpart of the... (England, Scotland, Wales, the Isle of Man, and Northern Ireland). Cattle. Animals of the bovine species...

29 CFR 98.1005 - State.

Science.gov (United States)

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true State. 98.1005 Section 98.1005 Labor Office of the Secretary of Labor GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Definitions § 98.1005 State. (a) State means— (1) Any of the states of the United States; (2) The District of Columbia; (3) The...

49 CFR 98.10 - Appeal.

Science.gov (United States)

2010-10-01

... Administration of Enforcement Proceedings § 98.10 Appeal. (a) Within 30 working days after receipt of a decision issued under § 98.8 or § 98.9 of this part, either the Departmental counsel or the former employee may appeal the decision to the Secretary. (b) In making a decision on an appeal, the Secretary shall consider...

45 CFR 98.14 - Plan process.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Plan process. 98.14 Section 98.14 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CHILD CARE AND DEVELOPMENT FUND General Application Procedures § 98.14 Plan process. In the development of each Plan, as required pursuant to § 98.17...

[Expressiona of c-Jun and collagens I and III in cultured human skin fibroblasts are affected by infrared ray radiation].

Science.gov (United States)

Liu, Ping; Yang, Rong-Li; Su, Hui; Li, Lin-Li; Song, Jian-Wen; Lu, Ning; Liu, Yu-Ze

2016-02-01

To observe the effect of solar infrared ray (IR) radiation on the expressions of c-Jun and collagens I and III in cultured human skin fibroblasts (HSFs) and explore the molecular mechanism by which IR radiation causes aging of the skin. Primarily cultured HSFs exposed to IR radiation were examined for changes of the cell viability with MTT assay. The mRNA and protein expressions of c-Jun and collagens I and III was detected with real-time quantitative PCR and immunocytochemistry. MTT assay showed that IR irradiation caused inhibition of cell proliferation compared with the control cells. The mRNA and protein expression of collagen I was decreased significantly by IR irradiation with the increase of the irradiation dose (Pradiation to initiate and promote skin photoaging.

NetiNeti: discovery of scientific names from text using machine learning methods

Directory of Open Access Journals (Sweden)

Akella Lakshmi

2012-08-01

Full Text Available Abstract Background A scientific name for an organism can be associated with almost all biological data. Name identification is an important step in many text mining tasks aiming to extract useful information from biological, biomedical and biodiversity text sources. A scientific name acts as an important metadata element to link biological information. Results We present NetiNeti (Name Extraction from Textual Information-Name Extraction for Taxonomic Indexing, a machine learning based approach for recognition of scientific names including the discovery of new species names from text that will also handle misspellings, OCR errors and other variations in names. The system generates candidate names using rules for scientific names and applies probabilistic machine learning methods to classify names based on structural features of candidate names and features derived from their contexts. NetiNeti can also disambiguate scientific names from other names using the contextual information. We evaluated NetiNeti on legacy biodiversity texts and biomedical literature (MEDLINE. NetiNeti performs better (precision = 98.9% and recall = 70.5% compared to a popular dictionary based approach (precision = 97.5% and recall = 54.3% on a 600-page biodiversity book that was manually marked by an annotator. On a small set of PubMed Central’s full text articles annotated with scientific names, the precision and recall values are 98.5% and 96.2% respectively. NetiNeti found more than 190,000 unique binomial and trinomial names in more than 1,880,000 PubMed records when used on the full MEDLINE database. NetiNeti also successfully identifies almost all of the new species names mentioned within web pages. Conclusions We present NetiNeti, a machine learning based approach for identification and discovery of scientific names. The system implementing the approach can be accessed at http://namefinding.ubio.org.

System Advisor Model: Flat Plate Photovoltaic Performance Modeling Validation Report

Energy Technology Data Exchange (ETDEWEB)

Freeman, Janine [National Renewable Energy Lab. (NREL), Golden, CO (United States); Whitmore, Jonathan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Kaffine, Leah [National Renewable Energy Lab. (NREL), Golden, CO (United States); Blair, Nate [National Renewable Energy Lab. (NREL), Golden, CO (United States); Dobos, Aron P. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2013-12-01

The System Advisor Model (SAM) is a free software tool that performs detailed analysis of both system performance and system financing for a variety of renewable energy technologies. This report provides detailed validation of the SAM flat plate photovoltaic performance model by comparing SAM-modeled PV system generation data to actual measured production data for nine PV systems ranging from 75 kW to greater than 25 MW in size. The results show strong agreement between SAM predictions and field data, with annualized prediction error below 3% for all fixed tilt cases and below 8% for all one axis tracked cases. The analysis concludes that snow cover and system outages are the primary sources of disagreement, and other deviations resulting from seasonal biases in the irradiation models and one axis tracking issues are discussed in detail.

Spectral Lidar Analysis and Terrain Classification in a Semi-Urban Environment

Science.gov (United States)

2017-03-01

the NAVAL POSTGRADUATE SCHOOL March 2017 Approved by: Richard Olsen Thesis Advisor Marcus Stefanou Co-Advisor James Newman ...ratios plausible for mare basalt parent material” (Kaula et al. 1974, 3049). 3. Clementine Launched 25 January 1994, the Clementine lunar probe...Additionally, the longitudes and the corresponding topography values are combined in Figure 98 to make an Apollo- style topography graph (See Figure 2) for

Scientific Culture and Its Role in International Negotiations

OpenAIRE

Gottstein, Klaus L.

2005-01-01

Scientists as diplomats (historical examples). Scientists as advisors to governments and the public. Nongovernmental organisations and international conferences on security questions, initiated by scientists and based on their professional culture.

Building Rapport between International Graduate Students and Their Faculty Advisors: Cross- Cultural Mentoring Relationships at the University of Guelph

Science.gov (United States)

Omar, Faiza; Mahone, James P.; Ngobia, Jane; FitzSimons, John

2016-01-01

Mentoring graduate students is very challenging, even when both the student and faculty have similar cultural values. Many international students have a different culture from that of Canadian. Their challenge is adapting to their new environment, and for their faculty advisors to understand and work well with them. This research explored the…

Validation of PV-RPM Code in the System Advisor Model.

Energy Technology Data Exchange (ETDEWEB)

Klise, Geoffrey Taylor [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lavrova, Olga [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Freeman, Janine [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2017-04-01

This paper describes efforts made by Sandia National Laboratories (SNL) and the National Renewable Energy Laboratory (NREL) to validate the SNL developed PV Reliability Performance Model (PV - RPM) algorithm as implemented in the NREL System Advisor Model (SAM). The PV - RPM model is a library of functions that estimates component failure and repair in a photovoltaic system over a desired simulation period. The failure and repair distributions in this paper are probabilistic representations of component failure and repair based on data collected by SNL for a PV power plant operating in Arizona. The validation effort focuses on whether the failure and repair dist ributions used in the SAM implementation result in estimated failures that match the expected failures developed in the proof - of - concept implementation. Results indicate that the SAM implementation of PV - RPM provides the same results as the proof - of - concep t implementation, indicating the algorithms were reproduced successfully.

Effects of interleukin-7/interleukin-7 receptor on RANKL-mediated osteoclast differentiation and ovariectomy-induced bone loss by regulating c-Fos/c-Jun pathway.

Science.gov (United States)

Zhao, Ji-Jun; Wu, Zhao-Feng; Yu, Ying-Hao; Wang, Ling; Cheng, Li

2018-09-01

To explore the effects of IL-7/IL-7R on the RANKL-mediated osteoclast differentiation in vitro and OVX-induced bone loss in vivo. BMMs and RAW264.7 were transfected with IL-7, IL-7R siRNA, c-Fos siRNA, and c-jun siRNA and later stimulated by RANKL. TRAP and toluidine blue staining were used to observe osteoclast formation and bone resorption, respectively. HE and TRAP staining were used to detect trabecular bone microstructure and osteoclasts of mice, respectively. qRT-PCR and Western blot analysis were used to examine expression. IL-7 unregulated the expression of CTSK, NFATc1, MMP9, and the phosphorylation of p38 and Akt by activating the c-Fos/c-Jun pathway, which increased osteoclast numbers and bone resorption in RANKL-stimulated macrophages. While IL-7R siRNA and c-Fos siRNA decreased the expression, as well as and the phosphorylation of p38 and Akt.IL-7 decreased the BMD and OPG expression in OVX-induced mice and increased the TRAP positive cells, the mRNA expression of c-fos, c-jun, and RANKL, which was contradictory to IL-7R siRNA, and c-Fos siRNA. Furthermore, IL-7R siRNA and c-Fos siRNA caused thicker trabeculae, increased trabecular number, and decreased osteolysis in OVX mice. IL-7/IL-7R can promote RANKL-mediated osteoclast formation and bone resorption by activating the c-Fos/c-Jun pathway, as well as inducing bone loss in OVX mice. © 2018 Wiley Periodicals, Inc.

CERN Technical training: Available places in forthcoming courses

CERN Multimedia

HR Department

2010-01-01

The following course sessions are scheduled in the framework of the 2010 CERN Technical Training Programme and places are still available. You can find the full updated Technical Training course programme in our web catalogue. Software and system technologies C++ Part 2: Object-Oriented and Generic Programming\t25-MAY-10\t28-MAY-10\tEnglish\t3 days CERN openlab Multi-threading and Parallelism Workshop\t04-MAY-10\t05-MAY-10\tEnglish\t2 days ITIL Foundations (version 3)\t31-MAY-10\t02-JUN-10\tEnglish\t3 days ITIL Foundations (version 3) EXAMINATION\t22-JUN-10\t22-JUN-10\tEnglish\t1 hour JAVA 2 Enterprise Edition - Part 2: Enterprise JavaBeans\t21-JUN-10\t23-JUN-10\tEnglish\t3 days JavaScript for web development\t05-MAY-10\t07-MAY-10\tEnglish\t3 days JCOP - Finite State Machines in the JCOP Framework\t22-JUN-10\t24-JUN-10\tEnglish\t3 days JCOP - Joint PVSS-JCOP Framework\t31-MAY-10\t04-JUN-10\tEnglish\t4.5 days Le Langage C (ANSI et C99)\t24-JUN-10\t02-JUL-10\tEnglish\t4 days Object-oriented Design Patterns\t10-MAY-10\t12-MAY-10\tEnglish\t3 days Orac...

78 FR 21349 - Meeting of the Board of Advisors to the Presidents of the Naval Postgraduate School and Naval War...

Science.gov (United States)

2013-04-10

... DEPARTMENT OF DEFENSE Department of the Navy Meeting of the Board of Advisors to the Presidents of the Naval Postgraduate School and Naval War College, Naval Postgraduate School Subcommittee AGENCY... War College report on progress to the Secretary of the Navy. The Board will meet in closed executive...

75 FR 53958 - Meeting of the Board of Advisors to the Presidents of the Naval Postgraduate School and the Naval...

Science.gov (United States)

2010-09-02

... the Naval Postgraduate School and the Naval War College AGENCY: Department of the Navy, DoD. ACTION... of Advisors (BOA) to the Presidents of the Naval Postgraduate School (NPS) and the Naval War College... elicit the advice of the Board on the Naval Service's Postgraduate Education Program and the...

Advisor-advisee relationship: the multiplier knowledge Relação orientador-orientando: o conhecimento multiplicador

Directory of Open Access Journals (Sweden)

Lydia Masako Ferreira

2009-06-01

Full Text Available The article captures the essence of the advisor-advisee relationship as the fulcrum of the graduate program, and its influence and implications in the present formation process of new researchers.O artigo resgata a essência da relação orientador-orientado como núcleo de sustentação de um programa de pós-graduação senso estrito e suas influências e implicações no processo atual de formação dos pesquisadores.

45 CFR 98.33 - Consumer education.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Consumer education. 98.33 Section 98.33 Public... Program Operations (Child Care Services)-Parental Rights and Responsibilities § 98.33 Consumer education... public consumer education information that will promote informed child care choices including, at a...

45 CFR 98.32 - Parental complaints.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Parental complaints. 98.32 Section 98.32 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CHILD CARE AND DEVELOPMENT FUND Program Operations (Child Care Services)-Parental Rights and Responsibilities § 98.32 Parental complaints...

Targeted Killing: Managing American Perceptions On Unmanned Aerial Vehicle Operations

Science.gov (United States)

2016-02-01

Requirements Proposal Advisor: Dr. Patricia Williams Lessane Project Advisor: Dr. Andrew Niesiobedzki Maxwell AFB, AL February 2016...epistemology of remote fighting." Ethics and Information Technology 15. no. 2. 87-98. Cullen , Peter. 2008. "The Role of Targeted Killing in the...in the Sky." New Statesman 19-25. June. 48. Patterson, Margot. 2015. "Are We Safer." America 212. no. 204. 12. Raven-Hansen, William C. Banks and

Navy Chaplains as Religious Advisors: A Combatant Commander’s Strategic Asset in Conflict, Reconstruction and Peace

Science.gov (United States)

2012-04-05

attempting to foster a climate of fairness, trust, and accountability .40 As the essential advisor, the chaplain operates as the moral conscience for the...local community. In doing so, the chaplain affords the widest possible free exercise of religion in the most cost effective manner. In addition...Operations, JP 1-05 (Washington, DC: Joint Forces Staff, November 2009), i. 13 SACNAVINST 1730.10, 1. 14 Clifford Drury , The History of the

Revisiting anomalous B(E2;41+→21+)/B(E2;21+→01+) values in 98Ru and 180Pt

International Nuclear Information System (INIS)

Williams, E.; Plettner, C.; McCutchan, E. A.; Levine, H.; Casten, R. F.; Ai, H.; Heinz, A.; Qian, J.; Meyer, D. A.; Werner, V.; Zamfir, N. V.; Cakirli, R. B.; Beausang, C. W.; Guerdal, G.; Pietralla, N.

2006-01-01

Recently, a set of nine nonmagic nuclei with anomalous values of the B(E2) ratio B 4/2 ≡B(E2;4 1 + →2 1 + )/B(E2;2 1 + →0 1 + ) 1 + →2 1 + ) values for two of these nuclei, 98 Ru and 180 Pt, were re-measured to determine if the current literature values for these nuclei are correct. 98 Ru was studied in a 27 Al( 98 Ru, 98 Ru*) Coulomb excitation experiment in inverse kinematics, while the lifetime of the 4 1 + state in 180 Pt was measured in a 122 Sn( 62 Ni, 4n) 180 Pt recoil distance method (RDM) experiment. For both nuclei, the remeasured B 4/2 values are well above 1, removing the deviations from collective models

A Career Exploration Program: An Effective Alternative to the Traditional Use of Faculty Advisors.

Science.gov (United States)

Olive, Kenneth E; Kwasigroch, Thomas E; Wooten, Daniel J; Lybrand, Cynthia; Peeples, Catherine R

2016-11-01

Providing medical students with resources to make effective career choices is challenging for medical schools as career options outnumber the formal clinical rotations students can experience during their undergraduate education. In 2009, the authors introduced the Career Exploration (CE) courses into the required curriculum at the Quillen College of Medicine. This three-course sequence includes large-group sessions addressing broad issues related to career choices, small-group specialty interest groups, individual student self-assessments, assignments through which students receive individualized feedback, and individual student advising sessions. The overall objective of the course sequence is to involve all students in career planning from the beginning of medical school so as to help them make more informed career decisions. The authors used improvement in student satisfaction with career planning activities as a surrogate measure for the outcome of helping students make more informed career choices. Students evaluated the CE courses positively, and overall satisfaction scores averaged 4 (1 = poor to 5 = excellent). Scores on Association of American Medical Colleges Graduation Questionnaire items related to career planning showed improved student satisfaction from 2010 to 2015. Succession planning for the first- and second-year career advisor is vital-as is faculty development for all clinical advisors to ensure that they have current information regarding both the curriculum and Match process, especially as residency selection becomes increasingly competitive. Enhancing the role of fourth-year students who serve as CE III mentors has the potential to prepare these students to be better teachers as residents.

Living between multiple sites: transnational family relations from the perspective of elderly non-migrants in Junín, Peru

NARCIS (Netherlands)

de Bruine, E.; Hordijk, M.; Tamagno, C.; Sánchez Arimborgo, Y.

2013-01-01

Transnationality—defined as maintaining a sense of familyhood across national borders—is a complex process. This article studies the complexities of transnationality by analysing remittance-sending and practices of connectivity between migrants and non-migrants from the Junín region in Peru, in

45 CFR 98.31 - Parental access.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Parental access. 98.31 Section 98.31 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CHILD CARE AND DEVELOPMENT FUND Program Operations (Child Care Services)-Parental Rights and Responsibilities § 98.31 Parental access. The...

SYNTHESIS, CHARACTERIZATION STUDIES OF 2-[(2 ...

African Journals Online (AJOL)

User

2016-06-01

Jun 1, 2016 ... re and Industrial Chemistry, Bayero University, Kano, P. M. B. 3011 Kano Nig ... methylidene}hydrazine-1-carboxamide has been synthesize emicarbazide. Its metal (II) ..... active though its complexes displayed enhanced.

29 CFR 98.920 - Civil judgment.

Science.gov (United States)

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Civil judgment. 98.920 Section 98.920 Labor Office of the Secretary of Labor GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Definitions § 98.920 Civil judgment. Civil judgment means the disposition of a civil action by any court of competent jurisdiction...

45 CFR 98.30 - Parental choice.

Science.gov (United States)

2010-10-01

... Program Operations (Child Care Services)-Parental Rights and Responsibilities § 98.30 Parental choice. (a... category of care; or (2) Having the effect of limiting parental access to or choice from among such... 45 Public Welfare 1 2010-10-01 2010-10-01 false Parental choice. 98.30 Section 98.30 Public...

27 CFR 6.98 - Advertising service.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Advertising service. 6.98 Section 6.98 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Exceptions § 6.98 Advertising service. The listing of the names...

75 FR 55592 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-09-13

... Conference Call). Contact Person: Tomas Drgon, PhD, Scientific Review Officer, HDM IRG, Center for Scientific..., [email protected] . Name of Committee: Cardiovascular and Respiratory Sciences Integrated Review Group...: Risk Prevention and Health Behavior. Date: October 21-22, 2010. Time: 8 a.m. to 5 p.m. Agenda: To...

A pilot study of StopAdvisor: a theory-based interactive internet-based smoking cessation intervention aimed across the social spectrum.

Science.gov (United States)

Brown, Jamie; Michie, Susan; Geraghty, Adam W A; Miller, Sascha; Yardley, Lucy; Gardner, Benjamin; Shahab, Lion; Stapleton, John A; West, Robert

2012-12-01

This article reports a pilot study of a new smoking cessation website ('StopAdvisor'), which has been developed on the basis of PRIME theory, evidence, web-design expertise and user-testing. The aims were to i) evaluate whether cessation, website usage and satisfaction were sufficiently high to warrant a randomised controlled trial (RCT) and ii) assess whether outcomes were affected by socio-economic status. This was an uncontrolled pilot study. Two hundred and four adult daily smokers willing to make a serious quit attempt were included. All participants received support from 'StopAdvisor', which recommends a structured quit plan and a variety of evidence-based behaviour change techniques for smoking cessation. A series of tunnelled sessions and a variety of interactive menus provide tailored support for up to a month before quitting through until one-month post-quit (http://www.lifeguideonline.org/player/play/stopadvisordemonstration). The primary outcome was self-report of at least 1month of continuous abstinence collected at 2months post-enrolment and verified by saliva cotinine or anabasine. Usage was indexed by log-ins and page views. Satisfaction was assessed by dichotomous ratings of helpfulness, personal relevance, likelihood of recommendation and future use, which were collected using an online questionnaire at 2months post-enrolment. Outcomes according to socio-economic status were assessed. At 8weeks post-enrolment, 19.6% (40/204) of participants were abstinent according to the primary outcome criteria (95% C.I.=14.1% to 25.1%). Participants viewed a mean of 133.5 pages (median=71.5) during 6.4 log-ins (median=3). A majority of respondents rated the website positively on each of the four satisfaction `ratings (range=66.7% to 75.3%). There was no evidence of an effect of socio-economic status on abstinence (OR=1.01, C.I.=0.50-2.07), usage (page-views, t(202)=0.11, p=.91; log-ins, t(202)=0.21, p=.83), or satisfaction (helpfulness, OR=1.09, C.I.=0

29 CFR 1915.98 - First aid.

Science.gov (United States)

2010-07-01

... 29 Labor 7 2010-07-01 2010-07-01 false First aid. 1915.98 Section 1915.98 Labor Regulations...) OCCUPATIONAL SAFETY AND HEALTH STANDARDS FOR SHIPYARD EMPLOYMENT General Working Conditions § 1915.98 First aid...) Unless a first aid room and a qualified attendant are close at hand and prepared to render first aid to...

[Summary of professor YANG Jun's experience for intractable facial paralysis].

Science.gov (United States)

Wang, Tao; Li, Zaiyuan; Ge, Tingqiu; Zhang, Man; Yuan, Aihong; Yang, Jun

2017-06-12

Professor YANG Jun 's experience of diagnosis and treatment for intractable facial paralysis is introduced. Professor YANG focuses on the thinking model that combines TCM, western medicine and acupuncture, and adopts the differentiation system that combines disease differentiation, syndrome differentiation and meridian differentiation; he adopts the treatment integrates etiological treatment, overall regulation, symptomatic treatment as well as acupuncture, moxibustion, medication and flash cupping. The acupoints of yangming meridians are mostly selected, and acupoints of governor vessel such as Dazhui (GV 14) and Jinsuo (GV 8) are highly valued. The multiple-needles shallow-penetration-insertion twirling lifting and thrusting technique are mostly adopted to achieve slow and mild acupuncture sensation; in addition, the facial muscles are pulled up with mechanics action. The intensive stimulation with electroacupuncture is recommended at Qianzheng (Extra), Yifeng (TE 17) and Yangbai (GB 14), which is given two or three treatments per week.

783.pdf | jun2015 | jess | Indian Academy of Sciences

Indian Academy of Sciences (India)

Ethical Guidelines and Procedures document. Posted on 17 January 2017. A revised version of the document 'Scientific Values: Ethical Guidelines and Procedures' has been produced by the Academy's Panel on Scientific Values. For more details, see the Academy Committee on Scientific Values page.

807.pdf | jun2015 | jess | Indian Academy of Sciences

Indian Academy of Sciences (India)

Ethical Guidelines and Procedures document. Posted on 17 January 2017. A revised version of the document 'Scientific Values: Ethical Guidelines and Procedures' has been produced by the Academy's Panel on Scientific Values. For more details, see the Academy Committee on Scientific Values page.

791.pdf | jun2014 | jess | Indian Academy of Sciences

Indian Academy of Sciences (India)

Ethical Guidelines and Procedures document. Posted on 17 January 2017. A revised version of the document 'Scientific Values: Ethical Guidelines and Procedures' has been produced by the Academy's Panel on Scientific Values. For more details, see the Academy Committee on Scientific Values page.

46 CFR 98.30-7 - Smoking.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Smoking. 98.30-7 Section 98.30-7 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS SPECIAL CONSTRUCTION, ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Portable Tanks § 98.30-7 Smoking. No person may smoke within 50 feet of a...

75 FR 32955 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-06-10

... evaluate grant applications. Place: Ritz Carlton Hotel, 1150 22nd Street, NW., Washington, DC 20037... grant applications. Place: Ritz-Carlton Hotel, 1150 22nd Street, NW., Boardroom, Washington, DC 20037... Hotel, 701 North Michigan Avenue, Chicago, IL 60611. Contact Person: Biao Tian, PhD, Scientific Review...

49 CFR 98.2 - Definitions.

Science.gov (United States)

2010-10-01

... Administration. (5) The National Highway Traffic Safety Administration. (6) The Urban Mass Transportation... 49 Transportation 1 2010-10-01 2010-10-01 false Definitions. 98.2 Section 98.2 Transportation Office of the Secretary of Transportation ENFORCEMENT OF RESTRICTIONS ON POST-EMPLOYMENT ACTIVITIES...

Parabolic Trough Reference Plant for Cost Modeling with the Solar Advisor Model (SAM)

Energy Technology Data Exchange (ETDEWEB)

Turchi, C.

2010-07-01

This report describes a component-based cost model developed for parabolic trough solar power plants. The cost model was developed by the National Renewable Energy Laboratory (NREL), assisted by WorleyParsons Group Inc., for use with NREL's Solar Advisor Model (SAM). This report includes an overview and explanation of the model, two summary contract reports from WorleyParsons, and an Excel spreadsheet for use with SAM. The cost study uses a reference plant with a 100-MWe capacity and six hours of thermal energy storage. Wet-cooling and dry-cooling configurations are considered. The spreadsheet includes capital and operating cost by component to allow users to estimate the impact of changes in component costs.

49 CFR 98.1 - Purpose.

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Purpose. 98.1 Section 98.1 Transportation Office of the Secretary of Transportation ENFORCEMENT OF RESTRICTIONS ON POST-EMPLOYMENT ACTIVITIES... administrative enforcement procedures that the Department of Transportation will follow when there is an...

International Scientific Symposium “Russia and the Turkic-Muslim World: Historical and Cultural Relations” (Yelabuga, April 21–22, 2016 »

Directory of Open Access Journals (Sweden)

M.S. Gatin

2016-09-01

Full Text Available April 21–22, in the city of Elabuga (Republic of Tatarstan there have been held International Scientific Symposium “Russia and the Turkic-Muslim World: Historical and Cultural Relations” and VIII International Turcologists’ conference “Islam and the Turkic World: Issues of Education, Language, Literature, History and Religion”. The organizers of the International Symposium and the conference were the Department of Turkology and Tatar studies of the Institute of International Relations, History and Oriental studies and the Yelabuga Institute of Kazan Federal University. The international academic event was attended by about 150 scholars and researchers from Russia, the US, Lithuania, Kazakhstan, Kyrgyzstan, Armenia, Georgia and other countries. The main purpose of the event was to discuss the research issues of history, culture, language and literature of Turkic peoples, the role and place of Islam in their historical destiny.

Production of no carrier added residue free /sup 22/Na

Energy Technology Data Exchange (ETDEWEB)

Britto, J L.Q. de; Bastos, M A.V.; Silva, R.F. da; Silva, A.G. da

1988-05-02

A method for the production of no carrier added and residue free /sup 22/Na, was developed via the /sup 24/Mg(d,..cap alpha..)/sup 22/Na nuclear reaction applying 14 MeV deuterons and a high current MG-Cu target. The yield for the reaction was measured and the chemical separation was performed using a Dowex 50WX8 resin in H/sup +/ form. The overall yield was higher than 98%. Residue could not be detected. All experiments were carried out at IEN's CV-28 cyclotron. (author) 13 refs.; 2 figs.

78 FR 14099 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-03-04

..., (301) 435-1165, [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict: Biopsychosocial Issues in Patient Management. Date: March 22, 2013. Time: 3:00 p..., Bethesda, MD 20892, 301-435-2365, [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review...

miR-138 protects cardiomyocytes from hypoxia-induced apoptosis via MLK3/JNK/c-jun pathway

Energy Technology Data Exchange (ETDEWEB)

He, Siyi; Liu, Peng; Jian, Zhao; Li, Jingwei; Zhu, Yun; Feng, Zezhou; Xiao, Yingbin, E-mail: xiaoyb@vip.sina.com

2013-11-29

Highlights: •First time to find miR-138 is up-regulated in hypoxic cardiomyocytes. •First time to find miR-138 targets MLK3 and regulates JNK/c-jun pathway. •Rare myocardial biopsy of patients with CHD were collected. •Both silence and overexpression of miR-138 were implemented. •Various methods were used to detect cell function. -- Abstract: Cardiomyocytes experience a series of complex endogenous regulatory mechanisms against apoptosis induced by chronic hypoxia. MicroRNAs are a class of endogenous small non-coding RNAs that regulate cellular pathophysiological processes. Recently, microRNA-138 (miR-138) has been found related to hypoxia, and beneficial for cell proliferation. Therefore, we intend to study the role of miR-138 in hypoxic cardiomyocytes and the main mechanism. Myocardial samples of patients with congenital heart disease (CHD) were collected to test miR-138 expression. Agomir or antagomir of miR-138 was transfected into H9C2 cells to investigate its effect on cell apoptosis. Higher miR-138 expression was observed in patients with cyanotic CHD, and its expression gradually increased with prolonged hypoxia time in H9C2 cells. Using MTT and LDH assays, cell growth was significantly greater in the agomir group than in the negative control (NC) group, while antagomir decreased cell survival. Dual luciferase reporter gene and Western-blot results confirmed MLK3 was a direct target of miR-138. It was found that miR-138 attenuated hypoxia-induced apoptosis using TUNEL, Hoechst staining and Annexin V-PE/7-AAD flow cytometry analysis. We further detected expression of apoptosis-related proteins. In the agomir group, the level of pro-apoptotic proteins such as cleaved-caspase-3, cleaved-PARP and Bad significantly reduced, while Bcl-2 and Bcl-2/Bax ratio increased. Opposite changes were observed in the antagomir group. Downstream targets of MLK3, JNK and c-jun, were also suppressed by miR-138. Our study demonstrates that up-regulation of miR-138 plays

Bex2 regulates cell proliferation and apoptosis in malignant glioma cells via the c-Jun NH2-terminal kinase pathway

International Nuclear Information System (INIS)

Zhou, Xiuping; Meng, Qingming; Xu, Xuebin; Zhi, Tongle; Shi, Qiong; Wang, Yong; Yu, Rutong

2012-01-01

Highlights: ► The expression levels of Bex2 markedly increased in glioma tissues. ► Bex2 over-expression promoted cell proliferation, while its down-regulation inhibited cell growth. ► Bex2 down-regulation promoted cell apoptosis via JNK/c-Jun signaling pathway. -- Abstract: The function of Bex2, a member of the Brain Expressed X-linked gene family, in glioma is controversial and its mechanism is largely unknown. We report here that Bex2 regulates cell proliferation and apoptosis in malignant glioma cells via the c-Jun NH2-terminal kinase (JNK) pathway. The expression level of Bex2 is markedly increased in glioma tissues. We observed that Bex2 over-expression promotes cell proliferation, while down-regulation of Bex2 inhibits cell growth. Furthermore, Bex2 down-regulation promotes cell apoptosis and activates the JNK pathway; these effects were abolished by administration of the JNK specific inhibitor, (SP600125). Thus, Bex2 may be an important player during the development of glioma.

Molecular risk assessment of BIG 1-98 participants by expression profiling using RNA from archival tissue

International Nuclear Information System (INIS)

Antonov, Janine; Altermatt, Hans Jörg; Aebi, Stefan; Jaggi, Rolf; Popovici, Vlad; Delorenzi, Mauro; Wirapati, Pratyaksha; Baltzer, Anna; Oberli, Andrea; Thürlimann, Beat; Giobbie-Hurder, Anita; Viale, Giuseppe

2010-01-01

The purpose of the work reported here is to test reliable molecular profiles using routinely processed formalin-fixed paraffin-embedded (FFPE) tissues from participants of the clinical trial BIG 1-98 with a median follow-up of 60 months. RNA from fresh frozen (FF) and FFPE tumor samples of 82 patients were used for quality control, and independent FFPE tissues of 342 postmenopausal participants of BIG 1-98 with ER-positive cancer were analyzed by measuring prospectively selected genes and computing scores representing the functions of the estrogen receptor (eight genes, ER-8), the progesterone receptor (five genes, PGR-5), Her2 (two genes, HER2-2), and proliferation (ten genes, PRO-10) by quantitative reverse transcription PCR (qRT-PCR) on TaqMan Low Density Arrays. Molecular scores were computed for each category and ER-8, PGR-5, HER2-2, and PRO-10 scores were combined into a RISK-25 score. Pearson correlation coefficients between FF- and FFPE-derived scores were at least 0.94 and high concordance was observed between molecular scores and immunohistochemical data. The HER2-2, PGR-5, PRO-10 and RISK-25 scores were significant predictors of disease free-survival (DFS) in univariate Cox proportional hazard regression. PRO-10 and RISK-25 scores predicted DFS in patients with histological grade II breast cancer and in lymph node positive disease. The PRO-10 and PGR-5 scores were independent predictors of DFS in multivariate Cox regression models incorporating clinical risk indicators; PRO-10 outperformed Ki-67 labeling index in multivariate Cox proportional hazard analyses. Scores representing the endocrine responsiveness and proliferation status of breast cancers were developed from gene expression analyses based on RNA derived from FFPE tissues. The validation of the molecular scores with tumor samples of participants of the BIG 1-98 trial demonstrates that such scores can serve as independent prognostic factors to estimate disease free survival (DFS) in

40 CFR 98.413 - Calculating GHG emissions.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Calculating GHG emissions. 98.413 Section 98.413 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Suppliers of Industrial Greenhouse Gases § 98.413 Calculating...

40 CFR 98.416 - Data reporting requirements.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Data reporting requirements. 98.416 Section 98.416 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Suppliers of Industrial Greenhouse Gases § 98.416 Data...

The life, times, and health care of Harry L Hopkins: Presidential advisor and perpetual patient.

Science.gov (United States)

Pappas, Theodore N; Swanson, Sven

2018-02-01

Harry Hopkins was the most important nontitled allied leader in World War II. He was the advisor to President Roosevelt who managed the diplomacy between Roosevelt, Churchill, and Stalin from 1941 to 1946. Throughout these times, Hopkins was ill and required transfusions, admissions to the hospital, and nutritional supplementation to keep him well enough to travel the world and manage the allied war diplomacy. There has been no unifying theory to account for all his symptoms and his reported pathologic and autopsy findings. In this paper, we will review his political and medical history and a differential diagnosis of his illness.

Creolising Political Identity and Social Scientific Method

African Journals Online (AJOL)

2014-06-16

Jun 16, 2014 ... When accepting the 2013 Latin American and Caribbean Regional ..... of theory emerging from Native or Latin America, the Caribbean, and .... Turner, Victor, 1969, The Ritual Process: Structure and Anti-Structure, Hawthorne,.

Reference Manual for the System Advisor Model's Wind Power Performance Model

Energy Technology Data Exchange (ETDEWEB)

Freeman, J.; Jorgenson, J.; Gilman, P.; Ferguson, T.

2014-08-01

This manual describes the National Renewable Energy Laboratory's System Advisor Model (SAM) wind power performance model. The model calculates the hourly electrical output of a single wind turbine or of a wind farm. The wind power performance model requires information about the wind resource, wind turbine specifications, wind farm layout (if applicable), and costs. In SAM, the performance model can be coupled to one of the financial models to calculate economic metrics for residential, commercial, or utility-scale wind projects. This manual describes the algorithms used by the wind power performance model, which is available in the SAM user interface and as part of the SAM Simulation Core (SSC) library, and is intended to supplement the user documentation that comes with the software.

40 CFR 98.406 - Data reporting requirements.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Data reporting requirements. 98.406 Section 98.406 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Suppliers of Natural Gas and Natural Gas Liquids § 98.406 Data...

Comportamiento de la eficiencia de los gobiernos locales de Junín mediante el análisis envolvente de datos

Directory of Open Access Journals (Sweden)

Ybnias Grijalva Yauri

2015-12-01

Full Text Available La investigación comprende el análisis de los niveles de eficiencia de los gobiernos locales de la región Junín, período 2009 - 2014, mediante el método de análisis envolvente de datos (DEA y el índice de Malmquist, que se aplican buscando el objetivo de identificar un conjunto de unidades de eficiencia que sirvan de referente a los gobiernos locales de la región y así impulsar el cumplimiento de la misión institucional y de las competencias de gobierno local y por ende promover el desarrollo integral de su jurisdicción . La hipótesis planteada fue que los gobiernos locales que reporten niveles de eficiencia alcanzarán el cumplimiento de su misión institucional y sus competencias así como el cumplimiento de sus funciones, logrando promover el desarrollo integral de su jurisdicción. Los resultados obtenidos, en función de tres competencias de los gobiernos locales (servicios públicos locales; organización del espacio físico y uso del suelo; servicios sociales locales, indican que los gobiernos locales de Junín no alcanzan niveles de eficiencia permanentes en el tiempo. En conclusión, no es posible identificar unidades de toma de decisiones (DMU de eficiencia que sirvan como referencia a los gobiernos locales de Junín, limitando el cumplimiento de su misión institucional y cabal desempeño de competencias y funciones, en desmedro del desarrollo económico y social de su jurisdicción.

40 CFR 98.412 - GHGs to report.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false GHGs to report. 98.412 Section 98.412 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Suppliers of Industrial Greenhouse Gases § 98.412 GHGs to report. You must report...

40 CFR 98.411 - Reporting threshold.

Science.gov (United States)

2010-07-01

...) MANDATORY GREENHOUSE GAS REPORTING Suppliers of Industrial Greenhouse Gases § 98.411 Reporting threshold. Any supplier of industrial greenhouse gases who meets the requirements of § 98.2(a)(4) must report GHG...

Presencia de Piscirickettsia salmonis en truchas de cultivo (Oncorhynchus mykiss) en Junín, Perú

OpenAIRE

Yunis A, Jefferson; Anicama D, Jahir; Manchego S, Alberto; Sandoval C, Nieves

2015-01-01

El objetivo de este estudio fue determinar la posible presencia de Piscirickettsia salmonis en truchas de cultivo (Oncorhynchus mykiss) en la cuenca del río Mantaro, Junín, Perú, mediante la prueba de inmunofluorescencia indirecta (IFI). Se obtuvieron 180 truchas en forma aleatoria de tres piscigranjas, se beneficiaron, se les realizó la necropsia y se recolectaron muestras de riñón y bazo. Los tejidos fueron sometidos a la prueba de inmunofluorescencia indirecta (IFI). Todas las muestras res...

46 CFR 98.25-65 - Filling density.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Filling density. 98.25-65 Section 98.25-65 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS SPECIAL... § 98.25-65 Filling density. (a) The filling density, or the percent ratio of the liquefied gas that may...

Shape Evolution in Neutron-Rich Krypton Isotopes Beyond N=60: First Spectroscopy of ^{98,100}Kr.

Science.gov (United States)

Flavigny, F; Doornenbal, P; Obertelli, A; Delaroche, J-P; Girod, M; Libert, J; Rodriguez, T R; Authelet, G; Baba, H; Calvet, D; Château, F; Chen, S; Corsi, A; Delbart, A; Gheller, J-M; Giganon, A; Gillibert, A; Lapoux, V; Motobayashi, T; Niikura, M; Paul, N; Roussé, J-Y; Sakurai, H; Santamaria, C; Steppenbeck, D; Taniuchi, R; Uesaka, T; Ando, T; Arici, T; Blazhev, A; Browne, F; Bruce, A; Carroll, R; Chung, L X; Cortés, M L; Dewald, M; Ding, B; Franchoo, S; Górska, M; Gottardo, A; Jungclaus, A; Lee, J; Lettmann, M; Linh, B D; Liu, J; Liu, Z; Lizarazo, C; Momiyama, S; Moschner, K; Nagamine, S; Nakatsuka, N; Nita, C; Nobs, C R; Olivier, L; Orlandi, R; Patel, Z; Podolyák, Zs; Rudigier, M; Saito, T; Shand, C; Söderström, P A; Stefan, I; Vaquero, V; Werner, V; Wimmer, K; Xu, Z

2017-06-16

We report on the first γ-ray spectroscopy of low-lying states in neutron-rich ^{98,100}Kr isotopes obtained from ^{99,101}Rb(p,2p) reactions at ∼220  MeV/nucleon. A reduction of the 2_{1}^{+} state energies beyond N=60 demonstrates a significant increase of deformation, shifted in neutron number compared to the sharper transition observed in strontium and zirconium isotopes. State-of-the-art beyond-mean-field calculations using the Gogny D1S interaction predict level energies in good agreement with experimental results. The identification of a low-lying (0_{2}^{+}, 2_{2}^{+}) state in ^{98}Kr provides the first experimental evidence of a competing configuration at low energy in neutron-rich krypton isotopes consistent with the oblate-prolate shape coexistence picture suggested by theory.

VAMIL and EIA regulations. Options for the installer/advisor; VAMIL- en EIA-regeling. Kansen voor installateur/adviseur

Energy Technology Data Exchange (ETDEWEB)

Wondergem, J. [Wondergem Intermedium, (Netherlands)

1997-03-01

The new title financial incentives regulations of the Dutch government are outlined. VAMIL and EIA came into effect January 1, 1997. The regulations offer the tax payer a number of financial advantages when investments are made for energy saving capital goods. Also for installers and advisors the regulations offer new chances to realize energy saving measures in maintenance, replacement or extension of existing installations. In this article attention is paid to the practical possibilities of the VAMIL and EIA regulations for the installation sector. 2 tabs.

Conditional deletion of CD98hc inhibits osteoclast development

Directory of Open Access Journals (Sweden)

Hideki Tsumura

2016-03-01

Full Text Available The CD98 heavy chain (CD98hc regulates virus-induced cell fusion and monocyte fusion, and is involved in amino acid transportation. Here, we examined the role that CD98hc plays in the formation of osteoclasts using CD98hcflox/floxLysM-cre peritoneal macrophages (CD98hc-defect macrophages. Peritoneal macrophages were stimulated with co-cultured with osteoblasts in the presence of 1,25(OH2 vitamin D3, and thereafter stained with tartrate-resistant acid phosphatase staining solution. The multinucleated osteoclast formation was severely impaired in the peritoneal macrophages isolated from the CD98hc-defect mice compared with those from wild-type mice. CD98hc mediates integrin signaling and amino acid transport through the CD98 light chain (CD98lc. In integrin signaling, suppression of the M-CSF-RANKL-induced phosphorylation of ERK, Akt, JNK and p130Cas were observed at the triggering phase in the CD98h-defect peritoneal macrophages. Moreover, we showed that the general control non-derepressible (GCN pathway, which was activated by amino acid starvation, was induced by the CD98hc-defect peritoneal macrophages stimulated with RANKL. These results indicate that CD98 plays two important roles in osteoclast formation through integrin signaling and amino acid transport.

46 CFR 98.30-11 - Cargo pumps.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Cargo pumps. 98.30-11 Section 98.30-11 Shipping COAST..., ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Portable Tanks § 98.30-11 Cargo pumps. No person may operate a cargo pump to transfer a product to or from a portable tank unless the pump...

pg319.pdf | Pdf2010Jun | Indian Academy of Sciences

Indian Academy of Sciences (India)

Ethical Guidelines and Procedures document. Posted on 17 January 2017. A revised version of the document 'Scientific Values: Ethical Guidelines and Procedures' has been produced by the Academy's Panel on Scientific Values. For more details, see the Academy Committee on Scientific Values page.

contjun2000.html | jun2000 | jessci | Indian Academy of Sciences

Indian Academy of Sciences (India)

Ethical Guidelines and Procedures document. Posted on 17 January 2017. A revised version of the document 'Scientific Values: Ethical Guidelines and Procedures' has been produced by the Academy's Panel on Scientific Values. For more details, see the Academy Committee on Scientific Values page.

Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells

DEFF Research Database (Denmark)

Størling, Joachim; Zaitsev, Sergei V; Kapelioukh, Iouri L

2005-01-01

The c-jun N-terminal kinase (JNK) signaling pathway mediates IL-1beta-induced apoptosis in insulin-secreting cells, a mechanism relevant to the destruction of pancreatic beta-cells in type 1 and 2 diabetes. However, the mechanisms that contribute to IL-1beta activation of JNK in beta-cells are la...

Merkel cell polyomavirus in Merkel cell carcinogenesis: small T antigen-mediates c-Jun phosphorylation.

Science.gov (United States)

Wu, Julie H; Simonette, Rebecca A; Nguyen, Harrison P; Rady, Peter L; Tyring, Stephen K

2016-06-01

Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer associated with the Merkel cell polyomavirus (MCPyV). The MCPyV genome, which is clonally integrated in the majority of MCCs, encodes the regulatory small T (sT) antigen. Previously, reports have established MCPyV sT antigen as a potent oncogene capable of inducing cell transformation. In the current study, we demonstrate a distinct role for c-Jun hyperactivation in MCPyV sT antigen pathogenesis. As MCPyV sT antigen's association with aggressive cancer growth has been previously established, this finding may represent a potential therapeutic target for the treatment of MCCs.

36 CFR 9.8 - Use of water.

Science.gov (United States)

2010-07-01

... MANAGEMENT Mining and Mining Claims § 9.8 Use of water. (a) No operator may use for operations any water from... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Use of water. 9.8 Section 9.8... Regional Director. The Regional Director shall not approve a plan of operations requiring the use of water...

FY 1998 Scientific and Technical Reports, Articles, Papers, and Presentations

Science.gov (United States)

Waits, J. E. Turner (Compiler)

1999-01-01

This document presents formal NASA technical reports, papers published in technical journals, and presentations by MSFC (Marshall Space Flight Center) personnel in FY98. It also includes papers of MSFC contractors. After being announced in STAR, all of the NASA series reports may be obtained from the National Technical Information Service. The information in this report may be of value to the scientific and engineering community in determining what information has been published and what is available.

14 CFR 61.98 - Flight proficiency.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Flight proficiency. 61.98 Section 61.98 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN...) Navigation; (viii) Slow flight and stalls; (ix) Emergency operations; and (x) Postflight procedures. (2) For...

Solar Electromagnetic Radiation Study for Solar Cycle 22: Solar Ultraviolet Irradiance, 120 to 300 NM: Report of Working Groups 2 and 3 of SOLERS 22

Science.gov (United States)

Rottman, G. J.; Cebula, R. P.; Gillotay, D.; Simon, P. A.

1996-01-01

This report summarizes the activities of Working Group 2 and Working Group 3 of the SOLax Electromagnetic Radiation Study for Solar Cycle 22 (SOLERS22) Program. The international (SOLERS22) is Project 1.2 of the Solar-Terrestrial Energy Program (STEP) sponsored by SCOSTEP, a committee of the International Council of Scientific Unions). SOLERS22 is comprised of five Working Groups, each concentrating on a specific wave-length range: WG-1 - visible and infrared, WG-2 - mid-ultraviolet (200 solar irradiance values in the specified wavelength ranges, 2) consider the evolving solar structures as the cause of temporal variations, and 3) understand the underlying physical processes driving these changes.

The Indigenous World, 1997-98 = El Mundo Indigena, 1997-98.

Science.gov (United States)

Erni, Christian, Ed.

This annual publication (published separately in English and Spanish) examines political, legal, social, environmental, and educational issues concerning indigenous peoples around the world during 1997-98. Part I highlights news events and ongoing situations in specific countries in nine world regions. In the Arctic and North America, these…

42 CFR 460.98 - Service delivery.

Science.gov (United States)

2010-10-01

... 42 Public Health 4 2010-10-01 2010-10-01 false Service delivery. 460.98 Section 460.98 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED..., national origin, religion, sex, age, sexual orientation, mental or physical disability, or source of...

75 FR 4576 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-01-28

...: Center for Scientific Review Special Emphasis Panel, Academic-Industry Partnership in Cancer Imaging.... Place: Ritz Carlton Hotel, 1150 22nd Street, NW., Washington, DC 20037. Contact Person: Fouad A. El...

Expression and Purification of Z Protein from Junín Virus

Directory of Open Access Journals (Sweden)

S. E. Goñi

2010-01-01

Full Text Available Arenaviridae comprises 23 recognized virus species with a bipartite ssRNA genome and an ambisense coding strategy. The virions are enveloped and include nonequimolar amounts of each genomic RNA species, designated L and S, coding for four ORFs (N, GPC, L, and Z. The arenavirus Junín (JUNV is the etiological agent of Argentine Hemorrhagic Fever, an acute disease with high mortality rate. It has been proposed that Z is the functional counterpart of the matrix proteins found in other negative-stranded enveloped RNA viruses. Here we report the optimized expression of a synthetic gene of Z protein, using three expression systems (two bacterial and a baculoviral one. One of these recombinant proteins was used to generate antibodies. A bioinformatic analysis was made where Z was subdivided into three domains. The data presented contributes methodologies for Z recombinant production and provides the basis for the development of new experiments to test its function.

78 FR 52580 - Excepted Service

Science.gov (United States)

2013-08-23

... Defense (Special Operations and Operations/Low Low Intensity Intensity Conflict Conflict). and.../2013 COMMISSION. Assistant. DEPARTMENT OF HEALTH AND HUMAN Office of the Senior Advisor DH130096 7/9... Senior Advisor DI130043 7/10/2013 United States Fish and Special Assistant DI130045 7/22/2013 Wildlife...

CERN Technical training: Available places in forthcoming courses

CERN Multimedia

HR Department

2010-01-01

The following course sessions are scheduled in the framework of the 2010 CERN Technical Training Programme and places are still available. You can find the full updated Technical Training course programme in our web catalogue. *************************************** Software and System Technologies JAVA - Level 2 05-JUL-10 08-JUL-10 English 4 days JCOP - Finite State Machines in the JCOP Framework  22-JUN-10 24-JUN-10 English 3 days Le Langage C (ANSI et C99) 24-JUN-10 02-JUL-10 English 4 days Oracle - Programming with PL/SQL  28-JUN-10  30-JUN-10  English 3 days Project Development using Python 29-JUN-10 ...

29 CFR 1910.98 - Effective dates.

Science.gov (United States)

2010-07-01

... 29 Labor 5 2010-07-01 2010-07-01 false Effective dates. 1910.98 Section 1910.98 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... section, if any standard in 41 CFR part 50-204, other than a national consensus standard incorporated by...

46 CFR 98.25-75 - Ventilation.

Science.gov (United States)

2010-10-01

... shall be fitted with efficient natural or mechanical ventilation. (b) Enclosed compartments in which... 46 Shipping 4 2010-10-01 2010-10-01 false Ventilation. 98.25-75 Section 98.25-75 Shipping COAST... Ventilation. (a) All enclosed spaces containing cargo tanks fitted with bottom outlet connections shall be...

50 CFR 665.98 - Management area.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Management area. 665.98 Section 665.98 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Management area. The American Samoa fishery management area is the EEZ seaward of the Territory of American...

AN EXPLORATORY STUDY OF DIVERSIFIED MENTORING RELATIONSHIPS AMONG GRADUATE STUDENTS AND THEIR ADVISORS IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS FIELDS

OpenAIRE

Bodden, Krystin R.

2014-01-01

Minorities and women continue to be underrepresented in science, technology, engineering, and mathematics (STEM) fields. In graduate education, factors such as racism, prejudice, discrimination, sexism, stereotypes, tokenism, and a lack of role models can all plague students and contribute to uncompleted degrees and non-entrance into STEM fields. One of the tools being used to combat these barriers is effective mentoring. Graduate students and their advisors generally have close working relat...

The EU needs more anticipatory funding of health and environmental research

DEFF Research Database (Denmark)

Hansen, Steffen Foss; Gee, David

2014-01-01

In recent months, there have been several attacks on the Precautionary Principle and how the principle has been used in the EU. For example, the scientific advisor to the President of the European Commission, Ann Glover, has accused Commissioners of having “crazy ideas” about the safety of nanote......In recent months, there have been several attacks on the Precautionary Principle and how the principle has been used in the EU. For example, the scientific advisor to the President of the European Commission, Ann Glover, has accused Commissioners of having “crazy ideas” about the safety...

Transient simulation for a real-time operator advisor expert system

International Nuclear Information System (INIS)

Jakubowski, T.; Hajek, B.K.; Miller, D.W.; Bhatnagar, R.

1990-01-01

An Operator Advisor (OA) consisting of four integrated expert systems has been under development at The Ohio State University since 1985. The OA, designed for a General Electric BWR-6 plant, has used the Perry Nuclear Power Plants full scope simulator near Cleveland, Ohio (USA) as the reference plant. The primary goal of this development has been to provide a single system which not only performs monitoring and diagnosis functions, but also provides fault mitigation procedures to the operator, monitors the performance of these procedures and provides backup procudures should the initial ones fail. To test the system off line, a transient event simulation methodology has been developed. The simulator employs event scenarios from the Perry simulator. Scenarios are selected to test both inter- and intra-modular system behavior and response and to verify the consistency and accuracy of the knowledge base. This paper describes the OA architecture and design and the transient simulation. A discussion of a sample scenario test, including the rationale for scenario selection, is included as an example. The results of the testing demonstrate the value of off line transient simulations in that they verify system operation and help to identify characteristics requiring further improvements

7 CFR 98.4 - Analytical methods.

Science.gov (United States)

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Analytical methods. 98.4 Section 98.4 Agriculture....4 Analytical methods. (a) The majority of analytical methods used by the USDA laboratories to perform analyses of meat, meat food products and MRE's are listed as follows: (1) Official Methods of...

46 CFR 98.33-11 - Smoking.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Smoking. 98.33-11 Section 98.33-11 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS SPECIAL CONSTRUCTION, ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Portable Tanks for Certain Grade E Combustible Liquids and Other Regulated...

45 CFR 98.34 - Parental rights and responsibilities.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Parental rights and responsibilities. 98.34 Section 98.34 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CHILD CARE AND DEVELOPMENT FUND Program Operations (Child Care Services)-Parental Rights and Responsibilities § 98.34...

45 CFR 98.65 - Audits and financial reporting.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Audits and financial reporting. 98.65 Section 98... DEVELOPMENT FUND Financial Management § 98.65 Audits and financial reporting. (a) Each Lead Agency shall have... independent standards. (g) The Secretary shall require financial reports as necessary. ...

Cloud-based crowd sensing: a framework for location-based crowd analyzer and advisor

Science.gov (United States)

Aishwarya, K. C.; Nambi, A.; Hudson, S.; Nadesh, R. K.

2017-11-01

Cloud computing is an emerging field of computer science to integrate and explore large and powerful computing systems and storages for personal and also for enterprise requirements. Mobile Cloud Computing is the inheritance of this concept towards mobile hand-held devices. Crowdsensing, or to be precise, Mobile Crowdsensing is the process of sharing resources from an available group of mobile handheld devices that support sharing of different resources such as data, memory and bandwidth to perform a single task for collective reasons. In this paper, we propose a framework to use Crowdsensing and perform a crowd analyzer and advisor whether the user can go to the place or not. This is an ongoing research and is a new concept to which the direction of cloud computing has shifted and is viable for more expansion in the near future.

UK minister and science advisors reassert roles of PWRs and FBRs

International Nuclear Information System (INIS)

Fishlock, D.

1988-01-01

Britain continues to vigorously debate the wisdom of privatizing its electricity supply system by breaking the Central Electricity Generating Board into three separate parts, with specific consequences for nuclear energy. What is already clear is that the proposed changes must have a profound impact on all long-term activities, from the future of the fast reactor to national research into the environmental impact of electricity supply. The Government stated that future use of nuclear energy is necessary. The Government then published a nuclear study by its own top technical advisors, the Advisory Council on Science and Technology (ACOST). ACOST recommends that Britain should abandon further research and development on gas-cooled reactors and concentrate wholeheartedly on the PWR, following what it says is the public inquiry's unequivocal endorsement of the Sizewell-B design. The Advisory Council also comments on the fast reactor, in the context of what it calls the Government's responsibility to underpin long-term ventures in power generation. It states that the technology is approaching commercialization

Creolising Political Identity and Social Scientific Method

African Journals Online (AJOL)

2014-06-16

Jun 16, 2014 ... *Associate Professor of Political Science and Africana Studies. ... it therefore operated in multiple languages and insisted that theoretical work is necessarily .... antislavery organisations and of the Haitian Revolution offer a good ..... for consideration is its disposition toward the nature of symbolic life. The.

[Bibliometric analysis of scientific articles on epidemiological study of burns in China].

Science.gov (United States)

Cheng, W F; Shen, Z A; Zhao, D X; Li, D W; Shang, Y R

2017-04-20

Objective: To analyze the current status of epidemiological study of burns in China, and to explore the related strategies. Methods: Retrospective or cross-sectional scientific articles in Chinese or English on epidemiological study of burns in China published from January 2005 to December 2015 were systemically retrieved from 4 databases. The databases include PubMed, Embase, China Biology Medicine disc, and Chinese Journals Full - text Database . From the results retrieved, data with regard to publication year, journal distribution, number of institutions participated in the study, affiliation of the first author and its location, and admission time span and age of patients in all the scientific articles were collected. Furthermore, the definition of age range and the grouping method of age of pediatric patients in English articles on epidemiological study of pediatric burns of China were recorded. Data were processed with descriptive statistical analysis. Results: A total of 256 scientific articles conforming to the study criteria were retrieved, among which 214 (83.59%) articles were in Chinese, and 42 (16.41%) articles were in English; 242 (94.53%) articles were retrospective studies, and 14 (5.47%) articles were cross-sectional studies. During the 11 years, the number of the relevant articles was fluctuant on the whole. The scientific articles were published in 130 journals, with 42 English articles in source journals for SCIENCE CITATION INDEX EXPANDED - JOURNAL LIST, accounting for 16.41%, and 116 Chinese articles in Source Journal for Chinese Scientific and Technical Papers, accounting for 45.31%. Totally 215 (83.98%) articles were single-center studies, and 29 (11.33%) articles were multicenter studies which were conducted by three or more centers. The number of affiliations of the first author of articles was 161 in total. The top 10 institutions regarding the article publishing number published 58 articles, accounting for 22.66%. Scientific articles on

Nucleoporin Nup98 mediates galectin-3 nuclear-cytoplasmic trafficking

Energy Technology Data Exchange (ETDEWEB)

Funasaka, Tatsuyoshi, E-mail: funasaka@staff.kanazawa-u.ac.jp [Laboratory of Molecular and Cellular Biology, Department of Biology, Faculty of Natural Systems, Institute of Science and Engineering, Kanazawa University, Ishikawa (Japan); Balan, Vitaly; Raz, Avraham [Department of Oncology and Pathology, Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, MI (United States); Wong, Richard W., E-mail: rwong@staff.kanazawa-u.ac.jp [Laboratory of Molecular and Cellular Biology, Department of Biology, Faculty of Natural Systems, Institute of Science and Engineering, Kanazawa University, Ishikawa (Japan); Bio-AFM Frontier Research Center, Kanazawa Kanazawa University, Ishikawa (Japan)

2013-04-26

Highlights: •Nuclear pore protein Nup98 is a novel binding partner of galectin-3. •Nup98 transports galectin-3 into cytoplasm. •Nup98 depletion leads to galectin-3 nuclear transport and induces growth retardation. •Nup98 may involve in ß-catenin pathway through interaction with galectin-3. -- Abstract: Nucleoporin Nup98 is a component of the nuclear pore complex, and is important in transport across the nuclear pore. Many studies implicate nucleoporin in cancer progression, but no direct mechanistic studies of its effect in cancer have been reported. We show here that Nup98 specifically regulates nucleus–cytoplasm transport of galectin-3, which is a ß-galactoside-binding protein that affects adhesion, migration, and cancer progression, and controls cell growth through the ß-catenin signaling pathway in cancer cells. Nup98 interacted with galectin-3 on the nuclear membrane, and promoted galectin-3 cytoplasmic translocation whereas other nucleoporins did not show these functions. Inversely, silencing of Nup98 expression by siRNA technique localized galectin-3 to the nucleus and retarded cell growth, which was rescued by Nup98 transfection. In addition, Nup98 RNA interference significantly suppressed downstream mRNA expression in the ß-catenin pathway, such as cyclin D1 and FRA-1, while nuclear galectin-3 binds to ß-catenin to inhibit transcriptional activity. Reduced expression of ß-catenin target genes is consistent with the Nup98 reduction and the galectin-3–nucleus translocation rate. Overall, the results show Nup98’s involvement in nuclear–cytoplasm translocation of galectin-3 and ß-catenin signaling pathway in regulating cell proliferation, and the results depicted here suggest a novel therapeutic target/modality for cancers.

Cytotoxic Activity of 3,6-Dihydroxyflavone in Human Cervical Cancer Cells and Its Therapeutic Effect on c-Jun N-Terminal Kinase Inhibition

Directory of Open Access Journals (Sweden)

Eunjung Lee

2014-08-01

Full Text Available Previously we have shown that 3,6-dihydroxyflavone (3,6-DHF is a potent agonist of the human peroxisome proliferator-activated receptor (hPPAR with cytotoxic effects on human cervical cancer cells. To date, the mechanisms by which 3,6-DHF exerts its antitumor effects on cervical cells have not been clearly defined. Here, we demonstrated that 3,6-DHF exhibits a novel antitumor activity against HeLa cells with IC50 values of 25 μM and 9.8 μM after 24 h and 48 h, respectively. We also showed that the anticancer effects of 3,6-DHF are mediated via the toll-like receptor (TLR 4/CD14, p38 mitogen-activated protein kinase (MAPK, Jun-N terminal kinase (JNK, extracellular-signaling regulated kinase (ERK, and cyclooxygenase (COX-2 pathways in lipopolysaccharide (LPS-stimulated RAW264.7 cells. We found that 3,6-DHF showed a similar IC50 (113 nM value to that of the JNK inhibitor, SP600125 (IC50 = 118 nM in a JNK1 kinase assay. Binding studies revealed that 3,6-DHF had a strong binding affinity to JNK1 (1.996 × 105 M−1 and that the 6-OH and the carbonyl oxygen of the C ring of 3,6-DHF participated in hydrogen bonding interactions with the carbonyl oxygen and the amide proton of Met111, respectively. Therefore, 3,6-DHF may be a candidate inhibitor of JNKs, with potent anticancer effects.

Confirmatory Factor Analysis of the Delirium Rating Scale Revised-98 (DRS-R98).

Science.gov (United States)

Thurber, Steven; Kishi, Yasuhiro; Trzepacz, Paula T; Franco, Jose G; Meagher, David J; Lee, Yanghyun; Kim, Jeong-Lan; Furlanetto, Leticia M; Negreiros, Daniel; Huang, Ming-Chyi; Chen, Chun-Hsin; Kean, Jacob; Leonard, Maeve

2015-01-01

Principal components analysis applied to the Delirium Rating Scale-Revised-98 contributes to understanding the delirium construct. Using a multisite pooled international delirium database, the authors applied confirmatory factor analysis to Delirium Rating Scale-Revised-98 scores from 859 adult patients evaluated by delirium experts (delirium, N=516; nondelirium, N=343). Confirmatory factor analysis found all diagnostic features and core symptoms (cognitive, language, thought process, sleep-wake cycle, motor retardation), except motor agitation, loaded onto factor 1. Motor agitation loaded onto factor 2 with noncore symptoms (delusions, affective lability, and perceptual disturbances). Factor 1 loading supports delirium as a single construct, but when accompanied by psychosis, motor agitation's role may not be solely as a circadian activity indicator.

Training need analysis for energy efficiency advisors and data bank of available training programs (9255 U 965)

International Nuclear Information System (INIS)

Lail, K.S.

1995-01-01

Development of a skill profile for an 'energy efficiency advisor' position, and production of a data base of available training programs undertaken by the Power Acquisition department of B.C. Hydro, were described. Driving forces for products and services at competitive prices and transition factors crucial to successful market positioning were outlined, along with future plans for securing a foothold in British Columbia. Desirable market oriented management principles and dynamic competitive marketing strategies were noted. It was concluded that the progression toward market-based dynamics would make changes occur more quickly and would require the introduction of tailored products and services

System Advisor Model, SAM 2014.1.14: General Description

Energy Technology Data Exchange (ETDEWEB)

Blair, Nate [National Renewable Energy Lab. (NREL), Golden, CO (United States); Dobos, Aron P. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Freeman, Janine [National Renewable Energy Lab. (NREL), Golden, CO (United States); Neises, Ty [National Renewable Energy Lab. (NREL), Golden, CO (United States); Wagner, Michael [National Renewable Energy Lab. (NREL), Golden, CO (United States); Ferguson, Tom [Global Resources, Northbrook, IL (United States); Gilman, Paul [National Renewable Energy Lab. (NREL), Golden, CO (United States); Janzou, Steven [Janzou Consulting, Idaho Springs, CO (United States)

2014-02-01

This document describes the capabilities of the U.S. Department of Energy and National Renewable Energy Laboratory's System Advisor Model (SAM), Version 2013.9.20, released on September 9, 2013. SAM is a computer model that calculates performance and financial metrics of renewable energy systems. Project developers, policy makers, equipment manufacturers, and researchers use graphs and tables of SAM results in the process of evaluating financial, technology, and incentive options for renewable energy projects. SAM simulates the performance of photovoltaic, concentrating solar power, solar water heating, wind, geothermal, biomass, and conventional power systems. The financial model can represent financial structures for projects that either buy and sell electricity at retail rates (residential and commercial) or sell electricity at a price determined in a power purchase agreement (utility). SAM's advanced simulation options facilitate parametric and sensitivity analyses, and statistical analysis capabilities are available for Monte Carlo simulation and weather variability (P50/P90) studies. SAM can also read input variables from Microsoft Excel worksheets. For software developers, the SAM software development kit (SDK) makes it possible to use SAM simulation modules in their applications written in C/C++, C#, Java, Python, and MATLAB. NREL provides both SAM and the SDK as free downloads at http://sam.nrel.gov. Technical support and more information about the software are available on the website.

Creolising Political Identity and Social Scientific Method

African Journals Online (AJOL)

2014-06-16

Jun 16, 2014 ... 65-80. © Council for the Development of Social Science Research in Africa, 2014 .... ongoing forms of cultural mixture were the radical and intensified nature ... Creole; the music one hears throughout the Caribbean or the Cajun food ... than casual cohabitation of social and political worlds, opportuni-.

Tank 241-AP-106, Grab samples, 6AP-98-1, 6AP-98-2 and 6AP-98-3 Analytical results for the final report

Energy Technology Data Exchange (ETDEWEB)

FULLER, R.K.

1999-02-23

This document is the final report for tank 241-AP-106 grab samples. Three grab samples 6AP-98-1, 6AP-98-2 and 6AP-98-3 were taken from riser 1 of tank 241-AP-106 on May 28, 1998 and received by the 222-S Laboratory on May 28, 1998. Analyses were performed in accordance with the ''Compatability Grab Sampling and Analysis Plan'' (TSAP) (Sasaki, 1998) and the ''Data Quality Objectives for Tank Farms Waste Compatability Program (DQO). The analytical results are presented in the data summary report. No notification limits were exceeded. The request for sample analysis received for AP-106 indicated that the samples were polychlorinated biphenyl (PCB) suspects. The results of this analysis indicated that no PCBs were present at the Toxic Substance Control Act (TSCA) regulated limit of 50 ppm. The results and raw data for the PCB analysis are included in this document.

Tank 241-AP-106, Grab samples, 6AP-98-1, 6AP-98-2 and 6AP-98-3 Analytical results for the final report

International Nuclear Information System (INIS)

FULLER, R.K.

1999-01-01

This document is the final report for tank 241-AP-106 grab samples. Three grab samples 6AP-98-1, 6AP-98-2 and 6AP-98-3 were taken from riser 1 of tank 241-AP-106 on May 28, 1998 and received by the 222-S Laboratory on May 28, 1998. Analyses were performed in accordance with the ''Compatability Grab Sampling and Analysis Plan'' (TSAP) (Sasaki, 1998) and the ''Data Quality Objectives for Tank Farms Waste Compatability Program (DQO). The analytical results are presented in the data summary report. No notification limits were exceeded. The request for sample analysis received for AP-106 indicated that the samples were polychlorinated biphenyl (PCB) suspects. The results of this analysis indicated that no PCBs were present at the Toxic Substance Control Act (TSCA) regulated limit of 50 ppm. The results and raw data for the PCB analysis are included in this document

45 CFR 98.3 - Effect on State law.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Effect on State law. 98.3 Section 98.3 Public... Goals, Purposes and Definitions § 98.3 Effect on State law. (a) Nothing in the Act or this part shall be construed to supersede or modify any provision of a State constitution or State law that prohibits the...

Scientific publications from Arab world in leading journals of Integrative and Complementary Medicine: a bibliometric analysis.

Science.gov (United States)

Zyoud, Sa'ed H; Al-Jabi, Samah W; Sweileh, Waleed M

2015-09-04

Bibliometric analysis is increasingly employed as a useful tool to assess the quantity and quality of research performance. The specific goal of the current study was to evaluate the performance of research output originating from Arab world and published in international Integrative and Complementary Medicine (ICM) journals. Original scientific publications and reviews from the 22 Arab countries that were published in 22 international peer-reviewed ICM journals during all previous years up to December 31(st) 2013, were screened using the Web of Science databases. Five hundred and ninety-one documents were retrieved from 19 ICM journals. The h-index of the set of papers under study was 47. The highest h-index was 27 for Morocco, 21 for Jordan, followed by 19 for each Kingdom of Saudi Arabia (KSA), and Egypt, and the lowest h-index was 1 for each of Comoros, Qatar, and Syrian Arab Republic. No data related to ICM were published from Djibouti, and Mauritania. After adjusting for economy and population power, Somalia (89), Morocco (32.5), Egypt (31.1), Yemen (21.4), and Palestine (21.2) had the highest research productivity. The total number of citations was 9,466, with an average citation of 16 per document. The study identified 262 (44.3 %) documents with 39 countries in Arab-foreign country collaborations. Arab authors collaborated most with countries in Europe (24.2 %), followed by countries in the Asia-Pacific region (9.8 %). Scientific research output in the ICM field in the Arab world region is increasing. Most of publications from Arab world in ICM filed were driven by societal use of medicinal plants and herbs. Search for new therapies from available low cost medicinal plants in Arab world has motivated many researchers in academia and pharmaceutical industry. Further investigation is required to support these findings in a wider journal as well as to improve research output in the field of ICM from Arab world region by investing in more national and

Dissertation Leadership Knowledge Transfer Using Sparsely Connected Networks with Bidirectional Edges: Case Study of Chester Hayden McCall Jr., His Dissertation Advisors, and His Students

Science.gov (United States)

Mallette, Leo A.

2012-01-01

There are many modes of information flow in the sciences: books, journals, conferences, research and development, acquisition of companies, co-workers, students, and professors in schools of higher learning. In the sciences, dissertation students learn from their dissertation advisor (or chairperson or mentor) and the other dissertation committee…

Aryl hydrocarbon receptor pathway activation enhances gastric cancer cell invasiveness likely through a c-Jun-dependent induction of matrix metalloproteinase-9

Directory of Open Access Journals (Sweden)

Song Xin

2009-04-01

Full Text Available Abstract Background Abberant aryl hydrocarbon receptor (AhR expression and AhR pathway activation are involved in gastric carcinogenesis. However, the relationship between AhR pathway activation and gastric cancer progression is still unclear. In present study, we used 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD, a classic and most potent ligand of AhR, to activate AhR pathway and investigated the effect of AhR pathway activation on human gastric cancer AGS cell invasion and explored the corresponding mechanism. Results To determine whether AhR pathway can be activated in AGS cells, we examined the expression of CYP1A1, a classic target gene of AhR pathway, following TCDD exposure. RT-PCR and western blot analysis showed that both CYP1A1 mRNA and protein expression were increased in a dose-dependent manner following TCDD treatment and AhR antagonist resveratrol (RSV could reverse this TCDD-induced CYP1A1 expression. To determine whether TCDD treatment of AGS cells results in an induction of MMP-9 expression, we detected MMP-9 mRNA using RT-PCR and detected MMP-9 enzymatic activity using gelatin zymography. The results showed that both MMP-9 mRNA expression and enzymatic activity were gradually increased with the concentration increase of TCDD in media and these changes could be reversed by RSV treatment in a dose-dependent manner. To examine whether AhR activation-induced MMP-9 expression and activity in AGS cells results in increased migration and invasion, we performed wound healing migration assay and transwell migration and invasion assay. After TCDD treatment, the migration distance and the migration and invasion abilities of AGS cells were increased with a dose-dependent manner. To demonstrate AhR activation-induced MMP-9 expression is mediated by c-Jun, siRNA transfection was performed to silence c-Jun mRNA in AGS cells. The results showed that MMP-9 mRNA expression and activity in untreated control AGS cells were very weak; After TCDD

Supervisión pedagógica y gestión institucional en la calidad educativa de la Institución Educativa "Glorioso Húsares de Junín" El Agustino-2016

OpenAIRE

Tripul Escobedo, Elena del Pilar

2017-01-01

La investigación presentó como propósito determinar la influencia Supervisión Pedagógica y Gestión Institucional en la calidad educativa de la Institución Educativa "Glorioso Húsares de Junín" El Agustino-2016. Dicho estudio empleo la metodología descriptiva de diseño no experimental, transversal. La población estuvo constituida por los docentes de la Institución Educativa "Glorioso Húsares de Junín" El Agustino-2016. Se utilizó el muestreo no probabilístico de carácter cens...

Phosphorylation of purified mitochondrial Voltage-Dependent Anion Channel by c-Jun N-terminal Kinase-3 modifies channel voltage-dependence

Directory of Open Access Journals (Sweden)

Rajeev Gupta

2017-06-01

Full Text Available Voltage-Dependent Anion Channel (VDAC phosphorylated by c-Jun N-terminal Kinase-3 (JNK3 was incorporated into the bilayer lipid membrane. Single-channel electrophysiological properties of the native and the phosphorylated VDAC were compared. The open probability versus voltage curve of the native VDAC displayed symmetry around the voltage axis, whereas that of the phosphorylated VDAC showed asymmetry. This result indicates that phosphorylation by JNK3 modifies voltage-dependence of VDAC.

Phosphorylation of purified mitochondrial Voltage-Dependent Anion Channel by c-Jun N-terminal Kinase-3 modifies channel voltage-dependence.

Science.gov (United States)

Gupta, Rajeev; Ghosh, Subhendu

2017-06-01

Voltage-Dependent Anion Channel (VDAC) phosphorylated by c-Jun N-terminal Kinase-3 (JNK3) was incorporated into the bilayer lipid membrane. Single-channel electrophysiological properties of the native and the phosphorylated VDAC were compared. The open probability versus voltage curve of the native VDAC displayed symmetry around the voltage axis, whereas that of the phosphorylated VDAC showed asymmetry. This result indicates that phosphorylation by JNK3 modifies voltage-dependence of VDAC.

Grain refinement of Al-Si9.8-Cu3.4 alloy by novel Al-3.5FeNb-1.5C master alloy and its effect on mechanical properties

Science.gov (United States)

Apparao, K. Ch; Birru, Anil Kumar

2018-01-01

A novel Al-3.5FeNb-1.5C master alloy with uniform microstructure was prepared using a melt reaction process for this study. In the master alloy, basic intermetallic particles such as NbAl3, NbC act as heterogeneous nucleation substrates during the solidification of aluminium. The grain refining performance of the novel master alloy on Al-Si9.8-Cu3.4 alloy has also been investigated. It is observed that the addition of 0.1 wt.% of Al-3.5FeNb-1.5C master alloy can induce very effective grain refinement of the Al-Si9.8-Cu3.4 alloy. The average grain size of α-Al is reduced to 22.90 μm from about 61.22 μm and most importantly, the inoculation of Al-Si9.8-Cu3.4 alloy with FeNb-C is not characterised by any visible poisoning effect, which is the drawback of using commercial Al-Ti-B master alloys on aluminium cast alloys. Therefore, the mechanical properties of the Al-Si9.8-Cu3.4 alloy have been improved obviously by the addition of the 0.1 wt.% of Al-3.5FeNb-1.5C master alloy, including the yield strength and elongation.

P50/P90 Analysis for Solar Energy Systems Using the System Advisor Model: Preprint

Energy Technology Data Exchange (ETDEWEB)

Dobos, A. P.; Gilman, P.; Kasberg, M.

2012-06-01

To secure competitive financing for a solar energy generation project, the economic risk associated with interannual solar resource variability must be quantified. One way to quantify this risk is to calculate exceedance probabilities representing the amount of energy expected to be produced by a plant. Many years of solar radiation and metereological data are required to determine these values, often called P50 or P90 values for the level of certainty they represent. This paper describes the two methods implemented in the National Renewable Energy Laboratory's System Advisor Model (SAM) to calculate P50 and P90 exceedance probabilities for solar energy projects. The methodology and supporting data sets are applicable to photovoltaic, solar water heating, and concentrating solar power (CSP) systems.

Hipertensión arterial y obesidad en indígenas asháninkas de la región Junín, Perú

Directory of Open Access Journals (Sweden)

Candice Romero

Full Text Available Con el objetivo de determinar la prevalencia de hipertensión arterial y obesidad en indígenas asháninkas, con limitado contacto con la cultura occidental, se realizó el 2008 un estudio transversal en cinco comunidades asháninkas de la región Junín en la selva del Perú. Se incluyó pobladores de 35 años a más siendo evaluados 76 sujetos (edad promedio 47,4 años, 52,6% mujeres, correspondientes al 43,2% de la población elegible. La prevalencia de hipertensión fue 14,5% (IC 95%: 6,4-22,6 y de obesidad según índice de masa corporal 4% (IC 95%: 0-8,4, sin diferencias según sexo. No hubo diferencias en niveles de presión arterial por grupos de edad. Comparada con estudios previos en pobladores no indígenas de la selva peruana la prevalencia de hipertensión fue elevada. Sin embargo, la prevalencia de obesidad fue baja. Nuestros hallazgos constituyen un llamado para no desatender la situación de las enfermedades crónicas no transmisibles en las poblaciones indígenas de la Amazonia del Perú

Values and ethical principles for practicing as magistrate/ legal advisor out of the perspective of the codes and national and international statements of principles

Directory of Open Access Journals (Sweden)

Marţian Iovan

2016-10-01

Full Text Available The coordinating and regulating role of the moral values, of the Deontological Code in practicing the magistrate/ legal advisor position is analysed in this article, so that their decisions correspond the universal imperative of practical accomplishment of justice, implicitly to the audience’s expectations with regard to the efficiency and efficacy of the services delivered by the institutions in the judicial system. The subject is of obvious actuality, fact which results in the existence of a relevant number of cases of violation, deforming of the ethical principles, of the specific deontological norms for the legal advisors, especially for the magistrates, which occur in performing the act of justice. The author highlights through examples, the harmful effects of some magistrates’ side-slipping from the ethical principles (Independence, Impartiality, Integrity stipulated in the most important deontological codes, statements of principles or national and international conventions. The logical conclusion, resulting from the analyses, aims to perfection the judicial system, the moral part of the legal higher education, of the magistrates’ continuous training and assessment.

Alternativas legales para negociación de la quinua de pequeños productores en la región Junín

Directory of Open Access Journals (Sweden)

Ricardo Solis Reategui

2015-06-01

Full Text Available El objetivo del presente trabajo es mostrar la situación de los pequeños productores de quinua de la región Junín y como la implementación que ya se ha dado en otras partes del país podrían mejorar su entorno con el uso de herramientas legales que podrían asegurar sus producciones a mejores precios y con mejor trato al productor original. Para la recopilación de la información se recurrió a la revisión de literatura especializada. Entre los hallazgos se puede mencionar que los pequeños productores expresan que los acopiadores y las empresas exportadoras no muestran interés alguno en apoyarlos. Para ellos el fin de los acopiadores y el exportador es lucrar a través de conseguir un menor precio en el productor. Entre las conclusiones del trabajo se puede mencionar que existe muy poca asociatividad en la región Junín, algunas instituciones del Estado y regionales apoyan el desarrollo asociativo pero de manera incipiente y con muy poca información. La quinua de la región Junín es considerada orgánica, y el precio que se paga por ella es bastante bajo respecto de la calidad de la misma comparativamente con la quinua de la costa, que trata de alcanzar el mismo precio pero con una producción intensiva con el uso de pesticidas y bioquímicos que limitan su ingreso a determinados mercados. Las autoridades locales y regionales deben ayudar a desarrollar pequeñas cadenas para mejorar la producción de quinua a través de asesoría técnica, consecuentemente un buen producto permitirá exigir un mejor precio y condiciones de pago.

Synsepalum dulcificum extracts exhibit cytotoxic activity on human colorectal cancer cells and upregulate c-fos and c-jun early apoptotic gene expression

Directory of Open Access Journals (Sweden)

Jichang Seong

2018-01-01

Full Text Available Objective: To explore cytotoxicity of Synsepalum dulcificum (S. dulcificum Daniell (Sapotaceae on human colon cancer (HCT-116 and HT-29, human monocytic leukemia (THP-1 and normal (HDFn cell lines, and its effect on the expression of early apoptotic genes, c-fos and c-jun. Methods: Leaf, stem and berry of S. dulcificum were separately extracted by using 2 solvents, 10% ethanol (EtOH and 80% methanol (MeOH. PrestoBlue® cell viability assay and qRT-PCR assay were conducted to examine the above objectives respectively. Results: Stem MeOH, stem EtOH, and berry EtOH extracts of S. dulcificum were cytotoxic to HCT-116 and HT-29 human colon cancer cells. For HCT-116, IC50 values of these 3 extracts were not significantly different (P>0.05 from that of the positive control bleomycin (IC50 of 33.57 μg/mL, while for HT-29, IC50 values of these 3 extracts were significantly lower (P<0.05 than that of bleomycin (IC50 of 25.24 μg/mL. None of the extracts were cytotoxic to the THP-1 monocytic leukemia cells and HDFn normal human dermal fibroblasts. For both HCT-116 and HT-29, these extracts significantly up-regulated (P<0.05 the expression of c-fos and c-jun compared to the untreated negative control. Conclusions: The results of this study suggest that cytotoxicity of stem MeOH, stem EtOH, and berry EtOH extracts of S. dulcificum on HCT-116 and HT-29 colon cancer cells is due to the induced apoptosis which is caused by the up-regulation of the expression of early apoptotic genes, c-fos and c-jun.

Dieta de Leopardus colocolo (Carnivora: Felidae en la Reserva Nacional de Junín, Junín, Perú

Directory of Open Access Journals (Sweden)

Ursula Fajardo

2014-05-01

Full Text Available Este estudio caracteriza la dieta de Leopardus colocolo en los alrededores del lago Junín, en el centro del Perú, a partir de los restos de las presas presentes en 43 heces. El origen de las heces del predador se determinó a partir del ADN mitocondrial de las células epiteliales intestinales adheridas a la superficie de las heces, utilizando como marcador la región de control. Los restos de las presas fueron identificados utilizando literatura especializada y la comparación con especímenes de colección, identificando un total of 14 ítems alimenticios pertenecientes a mamíferos de las familias Cricetidae (6, Chinchillidae (1 y Caviidae (1 y aves de las familias Anatidae (3 y Rallidae (2, y un grupo de aves no identificadas (1. Los roedores fueron el principal componente de la dieta de L. colocolo, en frecuencia y biomasa, seguido por las aves. Entre los ítems alimenticios consumidos, el roedor cricétido pequeño Calomys sp. fue el más frecuente; sin embargo, el mayor aporte de biomasa relativa fue proporcionado por el roedor mediano Cavia tschudii. La amplitud de nicho obtenida fue baja (Bsta= 0.17, indicando una dieta especializada. Nuestros resultados confirman que, como ocurre con la mayoría de felinos pequeños neotropicales, L. colocolo es un predador especializado en la captura de vertebrados, principalmente mamíferos pequeños. No se registró variación estacional en la dieta y el análisis de las clases de edad de los roedores cricétidos mostró que los adultos fueron los más consumidos. Se infiere que L. colocolo tiene un patrón de actividad diurno y nocturno.

What do physiotherapists and manual handling advisors consider the safest lifting posture, and do back beliefs influence their choice?

Science.gov (United States)

Nolan, David; O'Sullivan, Kieran; Stephenson, John; O'Sullivan, Peter; Lucock, Michael

2018-02-01

It is commonly believed lifting is dangerous and the back should be straight during lifting. These beliefs may arise from healthcare professionals, yet no study has evaluated the lifting and back beliefs of manual handling advisors (MHAs) and physiotherapists (PTs). To evaluate (i) what lifting technique MHAs and PTs perceive as safest, and why, and (ii) the back pain beliefs of MHAs and PTs. Data was collected via an electronic survey. Participants selected the safest lifting posture from four options: two with a straight back and two with a more rounded back, with justification. Back beliefs were collected via the Back-Pain Attitudes Questionnaire (Back-PAQ). Relationships were investigated using multiple linear and logistic regression models. 400 PTs and MHAs completed the survey. 75% of PTs and 91% of MHAs chose a straight lifting posture as safest, mostly on the basis that it avoided rounding of the back. MHAs scored significantly higher than PTs on the Back-PAQ instrument (mean difference = 33.9), indicating more negative back beliefs. Those who chose the straight back position had significantly more negative back beliefs (mean 81.9, SD 22.7) than those who chose a round back lift (mean 61.7, SD 21.1). Avoiding rounding the back while lifting is a common belief in PTs and MHAs, despite the lack of evidence that any specific spinal posture is a risk factor for low back pain. MHAs, and those who perceived a straight back position as safest, had significantly more negative back beliefs. Copyright © 2017 Elsevier Ltd. All rights reserved.

Preliminary evaluation of FY98 KALIMER shielding design

Energy Technology Data Exchange (ETDEWEB)

Yoo, Jae Woon; Kang, Chang Mu; Kim, Young Jin [Korea Atomic Energy Research Institute, Taejon (Korea)

1999-01-01

This report describes a preliminary evaluation of the shielding design of FY98 KALIMER. The KALIMER shielding design includes the Inner Fixed Shield of a stainless cylinder located inside the support barrel; the Radial PSDRS Shields which are three B{sub 4}C cylinders located outside the support barrel at core level; the Lower IHX shield of a cylindrical B{sub 4}C plate located above the flow guide; and Inner and Outer IHX shields of B{sub 4}C cylinders located inside and outside of the support barrel, respectively. The DORT3.1 two-dimensional transport code was used to evaluate the KALIMER shielding design. The reactor system was represented by four axial zones, each of which was modeled in the R-Z geometry. The KAFAX-F22 library was used in the analyses, which was generated from the JEF-2.2 of OECD/NEA files for LMR applications by KAERI. The performance of the KALIMER shielding design is compared against the shielding design criteria. The results indicate that the support barrel, upper grid plate, and other reactor structures meet the maximum neutron fluence and DPA limits established in the shielding design criteria. Activities of the air effluent in the PSDRS were also evaluated and are shown to satisfy the maximum permissible concentration (MPC) limits in 10 CFR Part 20. In the future, the validation of the DORT model by a detailed three dimensional calculation such as MCNP and the justification of the current shielding design limits are needed. (author). 13 refs., 23 figs., 31 tabs.

Scientific co-operation with IAEA in the field of marine radioactivity

International Nuclear Information System (INIS)

Bologa, S.Alexandru

1998-01-01

A short presentation of the communication presented in the Seminar on public information on peaceful uses of nuclear energy, NUCInfo'98, is given. It is emphasized the formation of RMRI specialists, its scientific co-operations with IAEA between 1986-1998 and participations in related scientific events. In the domain of specialists' formation there are mentioned the participation of members of the Institute in the training courses on marine radioecology, in the regional course on strategies and methodologies for applied marine radioactivity and environmental isotope studies for the Black Sea, and in the inter-regional course devoted to determination of radionuclides in environmental samples, held in 1986, 1994 and 1997, respectively. In the field of research co-operation there are presented the achievements obtained in the framework of five programs dealing mainly with monitoring of marine water, sediment and biota radioactivity in Romanian sector of Black Sea. Also reported are the participations and the contributions in the international scientific events devoted to marine environmental studies and the contributions to international databases

The relationship between waiting times and 'adherence' to the Scottish Intercollegiate Guidelines Network 98 guideline in autism spectrum disorder diagnostic services in Scotland.

Science.gov (United States)

McKenzie, Karen; Forsyth, Kirsty; O'Hare, Anne; McClure, Iain; Rutherford, Marion; Murray, Aja; Irvine, Linda

2016-05-01

The aim of this study was to explore the extent to which the Scottish Intercollegiate Guidelines Network 98 guidelines on the assessment and diagnosis of autism spectrum disorder were adhered to in child autism spectrum disorder diagnostic services in Scotland and whether there was a significant relationship between routine practice which more closely reflected these recommendations (increased adherence) and increased waiting times. Retrospective, cross-sectional case note analysis was applied to data from 80 case notes. Adherence ranged from a possible 0 (no adherence) to 19 (full adherence). Overall, 17/22 of the recommendations were adhered to in over 50 of the 80 cases and in 70 or more cases for 11/22 of the recommendations, with a mean adherence score of 16 (standard deviation = 1.9). No significant correlation was found between adherence and total wait time for untransformed (r = 0.15, p = 0.32) or transformed data (r = 0.12, p = 0.20). The results indicated that the assessment and diagnostic practices were consistent with the relevant Scottish Intercollegiate Guidelines Network 98 guideline recommendations. Increased adherence to the 19 included recommendations was not significantly related to increased total waiting times, indicating that the Scottish Intercollegiate Guidelines Network 98 recommendations have generally been integrated into practice, without a resultant increase in patient waits. © The Author(s) 2015.

40 CFR 98.414 - Monitoring and QA/QC requirements.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Monitoring and QA/QC requirements. 98.414 Section 98.414 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Suppliers of Industrial Greenhouse Gases § 98.414 Monitoring...

40 CFR 98.415 - Procedures for estimating missing data.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Procedures for estimating missing data. 98.415 Section 98.415 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Suppliers of Industrial Greenhouse Gases § 98.415...

40 CFR 98.196 - Data reporting requirements.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Data reporting requirements. 98.196 Section 98.196 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... use in a purification process). If CO2 was used on-site, provide the information in paragraphs (b)(17...

The knowledge-based framework for a nuclear power plant operator advisor

International Nuclear Information System (INIS)

Miller, D.W.

1989-01-01

An important facet in the design, development, and evaluation of aids for complex systems is the identification of the tasks performed by the operator. Operator aids utilizing artificial intelligence, or more specifically knowledge-based systems, require identification of these tasks in the context of a knowledge-based framework. In this context, the operator responses to the plant behavior are to monitor and comprehend the state of the plant, identify normal and abnormal plant conditions, diagnose abnormal plant conditions, predict plant response to specific control actions, and select the best available control action, implement a feasible control action, monitor system response to the control action, and correct for any inappropriate responses. These tasks have been identified to formulate a knowledge-based framework for an operator advisor under development at Ohio State University that utilizes the generic task methodology proposed by Chandrasekaran. The paper lays the foundation to identify the responses as a knowledge-based set of tasks in accordance with the expected human operator responses during an event. Initial evaluation of the expert system indicates the potential for an operator aid that will improve the operator's ability to respond to both anticipated and unanticipated events

Especies de miridae (hemiptera) registradas en algunos cultivos tropicales en Chanchamayo y Satipo. Junín - Perú

OpenAIRE

Arellano, Germán; Vergara, Clorinda

2016-01-01

El presente estudio tuvo como objetivo identificar las especies de insectos Miridae(Hemiptera) presentes en seis cultivos tropicales en la selva del Departamento de Junín, Perú. Se considera como base las recolecciones realizadas entre los años 1983 a 1987. El muestreo se basó en colectas periódicas semanales de insectos en las plantaciones de cafeto (Coffea arabica L.), papayo (Carica papaya L.), piña (Ananas comosus var. comosus (L.) Merr., Coppens & Leal), palto (Persea americana Mill), cí...

42 CFR 482.98 - Condition of participation: Human resources.

Science.gov (United States)

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Condition of participation: Human resources. 482.98 Section 482.98 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Specialty Hospitals Transplant Center Process Requirements § 482.98 Condition of participation: Human...

Excitation functions of the 98Mo+d reactions

International Nuclear Information System (INIS)

Zarubin, P.P.; Padalko, V.Yu.; Khrisanfov, Yu.V.; Lebedev, P.P.; Podkopaev, Yu.N.

The excitation functions of the 98 Mo+d reactions were studied. The energy dependence of (d,p),(d,n) and (d,α) reactions was investigated by the activation analysis. The energies of deuterons in the range (6-12) MeV were determined by means of the aluminium filters. 98 Mo foils with surface densities of 1.02, 0.23 and 0.14 mgxcm -2 with 98 Mo enrichment of 94.1% were used as targets. The gamma spectra were measured by a Ge(Li) detector. The 98 Mo(d,p) 99 Mo reaction excitation function was determined via detection of 739 and 181 keV γ-radiation of 99 Mo (Tsub(1/2)=66.47h); 140 keV γ-radiation of 99 Tc (Tsub(1/2)=6h) was detected for the 98 Mo(d,n) 99 Tc reaction excitation function determination and 460, 568, 1091, 1200 and 1492 keV γ-quanta of 96 Nb (Tsub(1/2)=23.35h) - for the 98 Mo(d,α) 96 Nb reaction. In the excitation function the wide extremum was observed at Esub(d) approximately 10 MeV. The ratio of cross sections σsup(m)(d,n)/σ(d,p) on the 98 Mo target was determined. The ratio σsup(m)(d,n)/σ(d,p) was found to be decreasing function of the deuteron energy. The relative cross sections were determined with an accuracy of +-5%, while for the absolute values of cross sections the accuracy was +-15%

Towards Scientific Literacy for Basic School Pupils: Which Profile ...

African Journals Online (AJOL)

cce

2005-06-30

Jun 30, 2005 ... The emphasis on providing science education for all students in an attempt to make citizens .... the most important profile dimension in teaching, learning and ... The goal is to promote the acquisition of higher-order thinking ...

45 CFR 98.13 - Applying for Funds.

Science.gov (United States)

2010-10-01

... General Application Procedures § 98.13 Applying for Funds. The Lead Agency of a State or Territory shall... lobbying payments; (3) An assurance that the Lead Agency provides a drug-free workplace pursuant to 45 CFR... in § 98.17; and (d) Such other information as specified by the Secretary. ...

7 CFR 1786.98 - Discounted present value.

Science.gov (United States)

2010-01-01

... 7 Agriculture 12 2010-01-01 2010-01-01 false Discounted present value. 1786.98 Section 1786.98... Discounted present value. (a) The Discounted Present Value shall be calculated by RUS before prepayment is made by summing the present values of all remaining payments on all outstanding notes according to the...

Advancing understanding of the sustainability of lay health advisor (LHA) programs for African-American women in community settings.

Science.gov (United States)

Shelton, Rachel C; Charles, Thana-Ashley; Dunston, Sheba King; Jandorf, Lina; Erwin, Deborah O

2017-09-01

Lay health advisor (LHA) programs have made strong contributions towards the elimination of health disparities and are increasingly being implemented to promote health and prevent disease. Developed in collaboration with African-American survivors, the National Witness Project (NWP) is an evidence-based, community-led LHA program that improves cancer screening among African-American women. NWP has been successfully disseminated, replicated, and implemented nationally in over 40 sites in 22 states in diverse community settings, reaching over 15,000 women annually. We sought to advance understanding of barriers and facilitators to the long-term implementation and sustainability of LHA programs in community settings from the viewpoint of the LHAs, as well as the broader impact of the program on African-American communities and LHAs. In the context of a mixed-methods study, in-depth telephone interviews were conducted among 76 African-American LHAs at eight NWP sites at baseline and 12-18 months later, between 2010 and 2013. Qualitative data provides insight into inner and outer contextual factors (e.g., community partnerships, site leadership, funding), implementation processes (e.g., training), as well as characteristics of the intervention (e.g., perceived need and fit in African-American community) and LHAs (e.g., motivations, burnout) that are perceived to impact the continued implementation and sustainability of NWP. Factors at the contextual levels and related to motivations of LHAs are critical to the sustainability of LHA programs. We discuss how findings are used to inform (1) the development of the LHA Sustainability Framework and (2) strategies to support the continued implementation and sustainability of evidence-based LHA interventions in community settings.

Using CBT with Anxious Language Learners: The Potential Role of the Learning Advisor

Directory of Open Access Journals (Sweden)

Neil Curry

2014-01-01

Full Text Available Foreign Language Anxiety (FLA can be a crippling condition for many students, preventing them from taking an active part in the classroom, and also retarding their L2 use in wider communicative situations. Providing learners with the tools to overcome anxiety on an individual basis is an area which needs further investigation. Cognitive Behaviour Therapy (CBT is a widespread counselling practice used to treat anxieties. It shares similarities with some techniques employed in Advising in Language Learning (ALL for helping students with language goals, and it is worthwhile investigating and raising awareness of how it can be used for FLA. The article describes major characteristics of FLA and also CBT, and then describes four functions which CBT and ALL share: goal-setting, guided discovery, Socratic questioning and use of reflection. Preliminary research also demonstrates how some of the practices associated with CBT could be applied by Learning Advisors to help students to overcome FLA.

Rika-Shoshi, the First Physics Experiment Textbook Published in Japanese and its Editor, Jun'ichi Udagawa

Science.gov (United States)

Takahashi, Hiroshi; Akabane, Akira; Shozawa, Jun; Tamaki, Toyomi

The aim of this study is to examine the teaching of physics experiment at elementary and secondary school levels at the time when Japanese science education commenced. In this report, we focused on the first Japanese textbook of physics experiment, Rika-Shoshi, published in 1882 and the editor of the book, Udagawa Jun'ichi. Many experiments in Rika-Shoshi can be performed using low-cost everyday materials. We compare Rika-Shoshi with the original English textbooks and describe Udagawa's physics teaching in the Gunma Normal School based on the documents in the Gunma University archives. We discuss how we can learn from physics education as taught about 130 years ago.

[Scientific dissemination of medical dissertations at the University of Lomé (Togo)].

Science.gov (United States)

Pitche, Palokinam T; Onipoh, Dodji K; Tchangai-Walla, Kissem L

2007-01-01

The medicine dissertation is often the last step of a physician's medical studies. Long considered a rite of passage, it is now regarded as a scientific work deserving attention from the national and international scientific community. The objectives of this study were to document the means by which dissertations at the University of Lomé Medical School are diffused and to determine their impact on the scientific production of medical school faculty. This cross-sectional study included all dissertations in medicine at the University of Lomé from 1993 through 2002. We interviewed dissertation supervisors and co-supervisors (questionnaire-structured interviews) and consulted the Medline and CNRS/PASCAL databases, scientific communication registers and local journals to collect information. During this period, 240 dissertations were defended at the University of Lomé medical school. More than half came from the departments of medicine (n=85, 35.4%), surgery (n=57, 23.7%) and paediatrics (n=51, 22.5%). The majority dealt with epidemiological (47 %) and clinical (35.8 %) themes, and only a small minority concerned topics in microbiology and biochemistry (7.5 %). Ninety-nine dissertations (41 %) were published: 54 (22.5%) in indexed journals and 45 (18.5 %) in non-indexed journals; 130 (54%) were delivered as papers or posters at scientific meetings. The distribution of published dissertations according to department showed that the departments of paediatrics (51.3 %), medicine (21.2 %) and surgery (21 %) had the best rates of publication in indexed journals, compared with obstetrics and gynaecology (4 %) and basic science (13.8 %) departments. During the study period, faculty at the University of Lomé medical school published 264 articles in indexed journals: dissertations accounted for only 20.4 %. Dissertations made up a higher proportion of publications in the paediatrics department (32.2 %) than in surgery (20.7 %), medicine (19.8 %), basis sciences (14 %) or

40 CFR 98.33 - Calculating GHG emissions.

Science.gov (United States)

2010-07-01

...)(2)(ii) of this section. MVC = Molar volume conversion factor (849.5 scf per kg-mole at standard... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING General Stationary Fuel Combustion Sources § 98.33 Calculating... volume of fuel combusted per year, from company records as defined in § 98.6 (express mass in short tons...

Dynamic association of NUP98 with the human genome.

Directory of Open Access Journals (Sweden)

Yun Liang

Full Text Available Faithful execution of developmental gene expression programs occurs at multiple levels and involves many different components such as transcription factors, histone-modification enzymes, and mRNA processing proteins. Recent evidence suggests that nucleoporins, well known components that control nucleo-cytoplasmic trafficking, have wide-ranging functions in developmental gene regulation that potentially extend beyond their role in nuclear transport. Whether the unexpected role of nuclear pore proteins in transcription regulation, which initially has been described in fungi and flies, also applies to human cells is unknown. Here we show at a genome-wide level that the nuclear pore protein NUP98 associates with developmentally regulated genes active during human embryonic stem cell differentiation. Overexpression of a dominant negative fragment of NUP98 levels decreases expression levels of NUP98-bound genes. In addition, we identify two modes of developmental gene regulation by NUP98 that are differentiated by the spatial localization of NUP98 target genes. Genes in the initial stage of developmental induction can associate with NUP98 that is embedded in the nuclear pores at the nuclear periphery. Alternatively, genes that are highly induced can interact with NUP98 in the nuclear interior, away from the nuclear pores. This work demonstrates for the first time that NUP98 dynamically associates with the human genome during differentiation, revealing a role of a nuclear pore protein in regulating developmental gene expression programs.

Impact of research investment on scientific productivity of junior researchers.

Science.gov (United States)

Farrokhyar, Forough; Bianco, Daniela; Dao, Dyda; Ghert, Michelle; Andruszkiewicz, Nicole; Sussman, Jonathan; Ginsberg, Jeffrey S

2016-12-01

There is a demand for providing evidence on the effectiveness of research investments on the promotion of novice researchers' scientific productivity and production of research with new initiatives and innovations. We used a mixed method approach to evaluate the funding effect of the New Investigator Fund (NIF) by comparing scientific productivity between award recipients and non-recipients. We reviewed NIF grant applications submitted from 2004 to 2013. Scientific productivity was assessed by confirming the publication of the NIF-submitted application. Online databases were searched, independently and in duplicate, to locate the publications. Applicants' perceptions and experiences were collected through a short survey and categorized into specified themes. Multivariable logistic regression was performed. Odds ratios (OR) with 95 % confidence intervals (CI) are reported. Of 296 applicants, 163 (55 %) were awarded. Gender, affiliation, and field of expertise did not affect funding decisions. More physicians with graduate education (32.0 %) and applicants with a doctorate degree (21.5 %) were awarded than applicants without postgraduate education (9.8 %). Basic science research (28.8 %), randomized controlled trials (24.5 %), and feasibility/pilot trials (13.3 %) were awarded more than observational designs (p   scientific productivity and professional growth of novice investigators and production of research with new initiatives and innovations. Further efforts are recommended to enhance the support of small grant funding programs.

Human Endometrial CD98 Is Essential for Blastocyst Adhesion

Science.gov (United States)

Domínguez, Francisco; Simón, Carlos; Quiñonero, Alicia; Ramírez, Miguel Ángel; González-Muñoz, Elena; Burghardt, Hans; Cervero, Ana; Martínez, Sebastián; Pellicer, Antonio; Palacín, Manuel; Sánchez-Madrid, Francisco; Yáñez-Mó, María

2010-01-01

Background Understanding the molecular basis of embryonic implantation is of great clinical and biological relevance. Little is currently known about the adhesion receptors that determine endometrial receptivity for embryonic implantation in humans. Methods and Principal Findings Using two human endometrial cell lines characterized by low and high receptivity, we identified the membrane receptor CD98 as a novel molecule selectively and significantly associated with the receptive phenotype. In human endometrial samples, CD98 was the only molecule studied whose expression was restricted to the implantation window in human endometrial tissue. CD98 expression was restricted to the apical surface and included in tetraspanin-enriched microdomains of primary endometrial epithelial cells, as demonstrated by the biochemical association between CD98 and tetraspanin CD9. CD98 expression was induced in vitro by treatment of primary endometrial epithelial cells with human chorionic gonadotropin, 17-β-estradiol, LIF or EGF. Endometrial overexpression of CD98 or tetraspanin CD9 greatly enhanced mouse blastocyst adhesion, while their siRNA-mediated depletion reduced the blastocyst adhesion rate. Conclusions These results indicate that CD98, a component of tetraspanin-enriched microdomains, appears to be an important determinant of human endometrial receptivity during the implantation window. PMID:20976164

European Science Notes Information Bulletin Reports on Current European/Middle Eastern Science

Science.gov (United States)

1990-02-01

throughout Europe exchanges of views among national scientific advisors , about weaknesses in the IT sector. Before 1984, the Eu- The report asserts...technology products and services. rather than annual levels, as in the U.S. The 3-year first Priorities include advanced computer hardware, robo - phase was...materials, while two- that previously, he and his advisors would be able to rank thirds of the 122 Type 11 proposals for focused university their

46 CFR 98.25-50 - Filling and discharge pipes.

Science.gov (United States)

2010-10-01

... with a secondary remote control of a type acceptable to the Commandant. (c) The excess flow, internal... 46 Shipping 4 2010-10-01 2010-10-01 false Filling and discharge pipes. 98.25-50 Section 98.25-50... § 98.25-50 Filling and discharge pipes. (a) Filling connections shall be provided with one of the...

Putting science at the heart of European policy

CERN Multimedia

2015-01-01

One year ago, the incoming European Commission President Jean-Claude Juncker shocked the scientific world by scrapping the post of Chief Scientific Advisor. This week, the Commission made amends by launching a well-considered Scientific Advisory Mechanism (SAM) that not only puts science back at the heart of policy, but does so in a much more structured and robust way than conferring such responsibility on a single individual.     The SAM has two independent strands: an advisory group of seven scientists, and funding through the Horizon 2020 programme for national academies and learned societies to network and collaborate on policy issues. Both are backed up by a secretariat at Commission headquarters in Brussels. When Mr Juncker scrapped the role of Chief Scientific Advisor, it was against a backdrop of sometimes vitriolic attacks on the incumbent, Anne Glover, due to her outspoken views on GMOs. Mr Juncker’s move was seen by some as simply giving in to a powerful lob...

Solar Electromagnetic Radiation Study for Solar Cycle 22: Solar Ultraviolet Irradiance, 120 to 300 NM: Report of Working Groups 2 and 3 of SOLERS 22

Science.gov (United States)

Rottman, G. J.; Cebula, R. P.; Gillotay, D.; Simon, P. A.

1996-01-01

This report summarizes the activities of Working Group 2 and Working Group 3 of the SOLax Electromagnetic Radiation Study for Solar Cycle 22 (SOLERS22) Program. The international (SOLERS22) is Project 1.2 of the Solar-Terrestrial Energy Program (STEP) sponsored by SCOSTEP, a committee of the International Council of Scientific Unions). SOLERS22 is comprised of five Working Groups, each concentrating on a specific wave-length range: WG-1 - visible and infrared, WG-2 - mid-ultraviolet (200 < A < 300 nm), WG-3 - Far-ultraviolet (lambda greater than 100 and lambda less than 200 nanometers), WG-4 - extreme-ultraviolet (lambda greater than 10 and lambda less than 100 nm), and WG-5 - X-ray (lambda greater than 1 and lambda less than 10 nano meters). The overarching goals of SOLERS22 are to: 1) establish daily solar irradiance values in the specified wavelength ranges, 2) consider the evolving solar structures as the cause of temporal variations, and 3) understand the underlying physical processes driving these changes.

Capacitaciones lúdicas en micro y pequeñas empresas del departamento de Junín

Directory of Open Access Journals (Sweden)

Roberto De La Torre Santana

2015-06-01

Full Text Available Los objetivos fueron, proponer metodologías lúdicas vivenciales de capacitación para medir su valoración por los pequeños y microempresarios de la región Junín; y demostrar la posibilidad de atender a este segmento de mercado con capacitaciones especializadas en centros adecuados. El estudio fue de caracter descriptivo y para la recopilación de datos se utilizó la técnica de la encuesta, aplicado a 803 pequeños y microempresarios de ocho zonas de la región Junín para conocer su periodicidad de capacitación, percepción frente a ella y su grado de conocimiento sobre las capacitaciones lúdicas. Sobre esta muestra fue determinada otra muestra para la realización de cuatro talleres de capacitación lúdica vivencial, orientados a comprobar la hipótesis; asimismo se aplicó la metodología de laboratorio de negocios de la OIT en 58 empresarios durante enero y febrero de 2014. Los resultados indican que el 100 % de los empresarios participantes en los cuatro talleres consideraron que la capacitación lúdica es de alta aplicabilidad para sus negocios; el 96,6 % la consideraron activa y nada aburrida; y el 100 % también mostraron su disposición de participar en más de estas capacitaciones, incluso propusieron una lista de cursos o temas que demandarían. En conclusión, las capacitaciones lúdicas son muy bien recibidas y valoradas por el 96,6 % de los empresarios que participaron en los talleres. Este segmento es muy importante y numeroso, que bien orientado y con productos de capacitación a su medida, puede aprovechar al máximo el mercado de capacitación lúdica.

The c-Jun N-terminal kinase pathway is critical for cell transformation by the latent membrane protein 1 of Epstein-Barr virus

International Nuclear Information System (INIS)

Kutz, Helmut; Reisbach, Gilbert; Schultheiss, Ute; Kieser, Arnd

2008-01-01

The latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) transforms cells activating signal transduction pathways such as NF-κB, PI3-kinase, or c-Jun N-terminal kinase (JNK). Here, we investigated the functional role of the LMP1-induced JNK pathway in cell transformation. Expression of a novel dominant-negative JNK1 allele caused a block of proliferation in LMP1-transformed Rat1 fibroblasts. The JNK-specific inhibitor SP600125 reproduced this effect in Rat1-LMP1 cells and efficiently interfered with proliferation of EBV-transformed lymphoblastoid cells (LCLs). Inhibition of the LMP1-induced JNK pathway in LCLs caused the downregulation of c-Jun and Cdc2, the essential G2/M cell cycle kinase, which was accompanied by a cell cycle arrest of LCLs at G2/M phase transition. Moreover, SP600125 retarded tumor growth of LCLs in a xenograft model in SCID mice. Our data support a critical role of the LMP1-induced JNK pathway for proliferation of LMP1-transformed cells and characterize JNK as a potential target for intervention against EBV-induced malignancies

75 FR 65020 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-10-21

.... Agenda: To review and evaluate grant applications. Place: The Ritz-Carlton Hotel, 1150 22nd Street, NW...: To review and evaluate grant applications. Place: InterContinental Mark Hopkins Hotel, 999 California... Hotel, 999 Ninth Street, NW., Washington, DC 20001. Contact Person: Weijia Ni, PhD, Scientific Review...

Tumor suppressor BLU inhibits proliferation of nasopharyngeal carcinoma cells by regulation of cell cycle, c-Jun N-terminal kinase and the cyclin D1 promoter

International Nuclear Information System (INIS)

Zhang, Xiangning; Liu, Hui; Li, Binbin; Huang, Peichun; Shao, Jianyong; He, Zhiwei

2012-01-01

Tumor suppressor genes function to regulate and block tumor cell proliferation. To explore the mechanisms underlying the tumor suppression of BLU/ZMYND10 gene on a frequently lost human chromosomal region, an adenoviral vector with BLU cDNA insert was constructed. BLU was re-expressed in nasopharyngeal carcinoma cells by transfection or viral infection. Clonogenic growth was assayed; cell cycle was analyzed by flow cytometry-based DNA content detection; c-Jun N-terminal kinase (JNK) and cyclin D1 promoter activities were measured by reporter gene assay, and phosphorylation was measured by immunoblotting. The data for each pair of groups were compared with Student t tests. BLU inhibits clonogenic growth of nasopharyngeal carcinoma cells, arrests cell cycle at G1 phase, downregulates JNK and cyclin D1 promoter activities, and inhibits phosphorylation of c-Jun. BLU inhibits growth of nasopharyngeal carcinoma cells by regulation of the JNK-cyclin D1 axis to exert tumor suppression

Ketamine inhibits tumor necrosis factor-α and interleukin-6 gene expressions in lipopolysaccharide-stimulated macrophages through suppression of toll-like receptor 4-mediated c-Jun N-terminal kinase phosphorylation and activator protein-1 activation

International Nuclear Information System (INIS)

Wu, G.-J.; Chen, T.-L.; Ueng, Y.-F.; Chen, R.-M.

2008-01-01

Our previous study showed that ketamine, an intravenous anesthetic agent, has anti-inflammatory effects. In this study, we further evaluated the effects of ketamine on the regulation of tumor necrosis factor-α (TNF-α) and interlukin-6 (IL-6) gene expressions and its possible signal-transducing mechanisms in lipopolysaccharide (LPS)-activated macrophages. Exposure of macrophages to 1, 10, and 100 μM ketamine, 100 ng/ml LPS, or a combination of ketamine and LPS for 1, 6, and 24 h was not cytotoxic to macrophages. A concentration of 1000 μM of ketamine alone or in combined treatment with LPS caused significant cell death. Administration of LPS increased cellular TNF-α and IL-6 protein levels in concentration- and time-dependent manners. Meanwhile, treatment with ketamine concentration- and time-dependently alleviated the enhanced effects. LPS induced TNF-α and IL-6 mRNA syntheses. Administration of ketamine at a therapeutic concentration (100 μM) significantly inhibited LPS-induced TNF-α and IL-6 mRNA expressions. Application of toll-like receptor 4 (TLR4) small interfering (si)RNA into macrophages decreased cellular TLR4 levels. Co-treatment of macrophages with ketamine and TLR4 siRNA decreased the LPS-induced TNF-α and IL-6 productions more than alone administration of TLR4 siRNA. LPS stimulated phosphorylation of c-Jun N-terminal kinase and translocation of c-Jun and c-Fos from the cytoplasm to nuclei. However, administration of ketamine significantly decreased LPS-induced activation of c-Jun N-terminal kinase and translocation of c-Jun and c-Fos. LPS increased the binding of nuclear extracts to activator protein-1 consensus DNA oligonucleotides. Administration of ketamine significantly ameliorated LPS-induced DNA binding activity of activator protein-1. Therefore, a clinically relevant concentration of ketamine can inhibit TNF-α and IL-6 gene expressions in LPS-activated macrophages. The suppressive mechanisms occur through suppression of TLR4-mediated

EFFECT OF COPPER ON PASSIVITY AND CORROSION ...

African Journals Online (AJOL)

2014-06-30

Jun 30, 2014 ... Fe (Aldrich 99.89%), Cu (99.98%) and graphite. ... sequential polishing with silicon carbide emery paper followed by diamond polishing. ... of these alloys makes the quantity of cementite increase and the structure change.

Medical Surveillance Monthly Report (MSMR). Volume 22, Number 6, June 2015

Science.gov (United States)

2015-06-01

unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 MSMR Vol. 22 No. 6 June...Drowning or submersion, not else-where classifi ed aNATO standardization agreement cause of injury code Service members are at risk for unintentional...diagno- sis post-Pap. Some women may have con- sented to submit to a urinalysis as a part of their clinical encounter. Because such test- ing is

Sub-Saharan Africa Report Tables of Contents JPRS-SSA-86-068, 1 July 1986- JPRS-SSA-86-095, 15 September 1986

Science.gov (United States)

1987-02-21

Grows, Cooperatives Under Greater Pressure (Sue Leeman; THE STAR, 5 Jun 86) 72 Nation’s Export Drive Into EC Markets Expected Xo Founder (Mick...Development (DAILY DISPATCH, 24 Jun 86) 61 Zulu King Criticizes Church Role in Black Crisis (THE STAR, 30 Jun 86) 62 Briefs New Intelligence Unit...8217 (SAPA, 21 Aug 86) 58 Buthelezi Discusses Afrikaner- Zulu Coexistence (SAPA, 22 Aug 86) 59 People’s Army Leader, ANC’s Modise Discusses

40 CFR 98.70 - Definition of source category.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Definition of source category. 98.70... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Ammonia Manufacturing § 98.70 Definition of source category...-based feedstock produced via steam reforming of a hydrocarbon. (b) Ammonia manufacturing processes in...

ORIGINAL ARTICLES

African Journals Online (AJOL)

2000-06-27

Jun 27, 2000 ... Batanero E, Villalba M, Monsalve Rl, Rodriguez R. Cross-reactivity between the major ... pollen and vegetable foods. lnt A rch Allergy lmmunol 1992; 98: 97-104. ... Allergy and Clinical Immunology Intemational 1994; 6: 80-.

Molten Salt Power Tower Cost Model for the System Advisor Model (SAM)

Energy Technology Data Exchange (ETDEWEB)

Turchi, C. S.; Heath, G. A.

2013-02-01

This report describes a component-based cost model developed for molten-salt power tower solar power plants. The cost model was developed by the National Renewable Energy Laboratory (NREL), using data from several prior studies, including a contracted analysis from WorleyParsons Group, which is included herein as an Appendix. The WorleyParsons' analysis also estimated material composition and mass for the plant to facilitate a life cycle analysis of the molten salt power tower technology. Details of the life cycle assessment have been published elsewhere. The cost model provides a reference plant that interfaces with NREL's System Advisor Model or SAM. The reference plant assumes a nominal 100-MWe (net) power tower running with a nitrate salt heat transfer fluid (HTF). Thermal energy storage is provided by direct storage of the HTF in a two-tank system. The design assumes dry-cooling. The model includes a spreadsheet that interfaces with SAM via the Excel Exchange option in SAM. The spreadsheet allows users to estimate the costs of different-size plants and to take into account changes in commodity prices. This report and the accompanying Excel spreadsheet can be downloaded at https://sam.nrel.gov/cost.

Detailed Physical Trough Model for NREL's Solar Advisor Model: Preprint

Energy Technology Data Exchange (ETDEWEB)

Wagner, M. J.; Blair, N.; Dobos, A.

2010-10-01

Solar Advisor Model (SAM) is a free software package made available by the National Renewable Energy Laboratory (NREL), Sandia National Laboratory, and the US Department of Energy. SAM contains hourly system performance and economic models for concentrating solar power (CSP) systems, photovoltaic, solar hot-water, and generic fuel-use technologies. Versions of SAM prior to 2010 included only the parabolic trough model based on Excelergy. This model uses top-level empirical performance curves to characterize plant behavior, and thus is limited in predictive capability for new technologies or component configurations. To address this and other functionality challenges, a new trough model; derived from physical first principles was commissioned to supplement the Excelergy-based empirical model. This new 'physical model' approaches the task of characterizing the performance of the whole parabolic trough plant by replacing empirical curve-fit relationships with more detailed calculations where practical. The resulting model matches the annual performance of the SAM empirical model (which has been previously verified with plant data) while maintaining run-times compatible with parametric analysis, adding additional flexibility in modeled system configurations, and providing more detailed performance calculations in the solar field, power block, piping, and storage subsystems.

R and D Quest - Jun 2004 issue

International Nuclear Information System (INIS)

2004-01-01

R and D Quest is the bulletin of MINT (Malaysian Institute for Nuclear Technology Research). It is monthly published to report the R and D activities of MINT's researchers. The contents of R and D Quest are divided into 5 sections i.e. researchers column, recent publication, scientific visit, strategic partnership/news and conferences and seminars. In this issue, MINT's proudly announced first MINT researcher being awarded with International Scientist of the Year 2004. This news appear in researchers column together with other article such as Trailing the Neutron, insight of International Conference on Biomaterials and Tissue Engineering (IC-BITE' 04), Traditional Medical Products and New Chemical Entities Must Adhere to Regulatory Procedures, new facility R and D Loop at MINTec-Sinagama, progress report of oud In Quest of the Mystical Fragrance of Oud and latest find out in Laser Makes Material Stress Visible. A scientific visit reported the successful news of MIREC Audits First Modern Incinerator Commissioning in Labuan. Lastly, there are six new lists of presentations and publications, six and five new lists of courses, seminars and workshops for June and July

7 CFR 98.1 - General.

Science.gov (United States)

2010-01-01

..., READY-TO-EAT (MRE's), MEATS, AND MEAT PRODUCTS MRE's, Meats, and Related Meat Food Products § 98.1 General. Analytical services of meat and meat food products are performed for fat, moisture, salt, protein...

A V ampersand V Program for a real time Operator Advisor expert system

International Nuclear Information System (INIS)

Hajek, B.K.; Hardy, C.R.; Miller, D.W.; Bhatnagar, R.

1989-01-01

This report discusses an Operator Advisor (OA) consisting of four integrated expert systems which has been under development at the Ohio State University since 1985. The OA was initially conceived as two independent systems, one to manage procedures for the operator, and the other to diagnose plant faults and to validate sensor data. The OA has used the Perry Nuclear Power Plant simulator as the reference plant. It has been programmed with knowledge gathered from power plant experts and plant documents. Following incremental programming, the OA has been tested off line by running scenarios on the plant simulator and verifying that the OA responded as predicted by the simulator. Specifications have been developed and periodically published in the literature over the past four years. These are currently being collected and expanded upon as part of a formal Verification and Validation (V ampersand V) Program. The V ampersand V Program is defined by three types of documents: specification documents, a V ampersand V document, and procedures to support implementation of the specifications and V ampersand V programs

A V and V program for a real time operator advisor expert system

International Nuclear Information System (INIS)

Hajek, B.K.; Hardy, C.R.; Miller, D.W.; Bhatnagar, R.

1991-01-01

This paper reports on an Operator Advisor (OA) consisting of four integrated expert systems under development at The Ohio State University since 1985. The OA was initially conceived as two independent systems, one to manage procedures for the operator, and the other to diagnose plant faults and to validate sensor data. The OA has used the Perry Nuclear Power Plant simulator as the reference plant. It has been programmed with knowledge gathered from power plant experts and plant documents. Following incremental programming, the OA has been tested off line by running scenarios on the plant simulator and verifying that the OA responded as predicted by the simulator. Specifications have been developed and periodically published in the literature over the past four years. These are currently being collected and expanded upon as part of a formal Verification and Validation (V and V) Program. The V and V Program is defined by three types of documents: specification documents, a V and V document, and procedures to support implementation of the specifications and V and V program

P. Gluckman Chief Science Advisor to the Prime Minister, New Zealand signing the Guest book with CERN Director-General R. Heuer and Head of International Relations R. Voss. Accompanied by A. Bell throughout.

CERN Multimedia

Anna Pantelia

2013-01-01

P. Gluckman Chief Science Advisor to the Prime Minister, New Zealand signing the Guest book with CERN Director-General R. Heuer and Head of International Relations R. Voss. Accompanied by A. Bell throughout.

40 CFR 98.417 - Records that must be retained.

Science.gov (United States)

2010-07-01

... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Suppliers of Industrial Greenhouse Gases § 98.417 Records that... reported under § 98.416. (2) Records documenting the initial and periodic calibration of the gas...

Scientific events of the Turner Scientific And Research Institute for children’s orthopedics as a form of continuous medical education for pediatric traumatologists

Directory of Open Access Journals (Sweden)

Karina S. Solovyova

2017-03-01

Full Text Available The experience of the Turner Scientific and Research Institute for Children's Orthopedics in educational activities for improvement of the professional knowledge of pediatric physicians was represented. The target audience of the continuous medical education include traumatologists, pediatric surgeons, and doctors of related specialties of Russia that are involved in diagnosis, treatment, and rehabilitation of children with injuries, congenital and acquired diseases of the musculoskeletal system. Since 1986, the Institute has organized 28 all-Russian scientific and practical conferences on topical issues of traumatology and orthopedics of pediatric age in 22 different cities across the country. In the interest of the institute, the school of pediatric orthopedists is constantly working for district orthopedists of children's polyclinics of St. Petersburg, and regular monothematic seminars are performed with the participation of leading Russian experts and visiting lecturers from abroad. These scientific and practical activities improve the professional skills of doctors and help them improve the provision of specialized care to children.

78 FR 57383 - Human Studies Review Board; Notification of a Public Meeting

Science.gov (United States)

2013-09-18

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-ORD-2013-0626; FRL-9900-98-ORD] Human Studies Review Board; Notification of a Public Meeting AGENCY: U.S. Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: The EPA Office of the Science Advisor announces a public meeting of the Human Studies Review Board to...

9 CFR 98.36 - Animal semen from Canada.

Science.gov (United States)

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Animal semen from Canada. 98.36... CERTAIN ANIMAL EMBRYOS AND ANIMAL SEMEN Certain Animal Semen § 98.36 Animal semen from Canada. (a) General importation requirements for animal semen from Canada. If the product is . . . Then . . . (1) Equine semen...

ONRASIA Scientific Information Bulletin. Volume 17, Number 2, Apr-Jun 1992

Science.gov (United States)

1992-06-01

tech- Dr. Masashi lizumi nology is now mature. The nuclear ship , Deputy Director General 0 Nuclear ship MUTSU , has been behind schedule Tokai Research...facility at the National Insti- side of the main (Honshu) island. Dr. Masayuki Akimoto tute of Standards and Technology Nuclear ship research occurs at...development of a new amorphous such as nuclear power plants, ships , oil reported in the next section of this (cobalt based?) metalwith much lower drilling

Experience with diagnostic laparoscopy for gynecological indications

African Journals Online (AJOL)

2012-02-27

Feb 27, 2012 ... Nigerian Journal of Clinical Practice • Apr-Jun 2013 • Vol 16 • Issue 2 ... Statistical Analysis Used: Simple percentage method was used. Results: Infertility was the commonest indication for 1627 (98.4%) procedures, while ...

R and D Quest - Jun 2004 issue

International Nuclear Information System (INIS)

2004-01-01

R and D Quest is the bulletin of MINT (Malaysian Institute for Nuclear Technology Research). It is monthly published to report the R and D activities of MINT's researchers. The contents of R and D Quest are divided into five sections i.e. researchers column, recent publication, scientific visit, strategic partnership/news and conferences and seminars. In this issue, the focus is on researchers column is MINT's new facilities, i.e. robotic system for handling radioactive materials and assisting radiographers in case of stuck sources, jet pump with mathematical capability for supporting various field of applied research and Scanning Electron Microscope (SEM) for specimens imaging with a very fine scale result. Other articles are details On International Forum on Creativity, new enactment of Plant Variety Protection (PVP), Electronic Networking and Outreach (ENO) to make an impact on RCA Meetings, radiocarbon dating demonstration in New discovery in Malacca, Herbal Asia 2004 and Adventure on the High Seas a second phase of marine sample collection in the Straits of Malacca. Mission to Assist Sudan in Research, Education and Training complete the scientific visit section six new publications and presentations reported. This issue also published lists of courses, seminars and workshops in May and June

Guidance on the scientific requirements for health claims related to gut and immune function

DEFF Research Database (Denmark)

Tetens, Inge

2011-01-01

The European Food Safety Authority (EFSA) asked the Panel on Dietetic Products Nutrition and Allergies (NDA) to draft guidance on scientific requirements for health claims related to gut and immune function. This guidance has been drawn from scientific opinions of the NDA Panel on such health......, was subjected to public consultation (28 September 2010 to 22 October 2010), and was also discussed at a technical meeting with experts in the field on 2 December 2010 in Amsterdam....

75 FR 54156 - Center for Scientific Review; Amended Notice of Meeting

Science.gov (United States)

2010-09-03

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the Language and Communication Study Section, October 4, 2010, 8 a.m. to October 5, 2010, 5 p.m., Ritz Carlton Hotel, 1150 22nd...

Stockholm '98

Index Scriptorium Estoniae

1998-01-01

Live Music for Vibrant Dance-etendused 17.-23. aug. Rootsi balletikoolis, The Bomb Party - muusikaline etendus Göteborgi Ooperilt 18.-20. aug. Folkoperas ja Euroopa Liidu Noorteorkestri kontserdid 18., 22. aug

Summaries of the 40. Scientific Assembly of Polish Chemical Society and Association of Engineers and Technicians of Chemical Industry

International Nuclear Information System (INIS)

1997-01-01

Annual 40. Scientific Assembly of Polish Chemical Society and Association of Engineers and Technicians of Chemical Industry has been held in Gdansk on 22-26 September 1997. The most valuable scientific results obtained in Polish Laboratories have been presented in 22 main sections and 7 symposia directed especially at following subjects: analytical chemistry, biochemistry, solid state chemistry and material science, physical chemistry, heteroorganic and coordination chemistry, medical and pharmaceutical chemistry, metalorganic chemistry, inorganic and organic chemistry, polymers chemistry, chemistry and environment protection, theoretical chemistry, chemical didactics, photochemistry, radiation chemistry and chemical kinetics, chemical engineering, catalysis, crystallochemistry, chemical technology, electrochemistry, and instrumental methods

Plan to increase public access to the results of Federally-funded scientific research results.

Science.gov (United States)

2015-12-16

This plan is issued in response to the February 22, 2013 Office of Science and Technology Policy (OSTP) Memorandum for the Heads of Executive Departments and Agencies entitled Increasing Access to the Results of Federally Funded Scientific Researc...

Science of Guessing Passwords

Indian Academy of Sciences (India)

First page Back Continue Last page Graphics. Science of Guessing Passwords. Joseph Bonneau. Ph.D. Thesis,. Univ. of Cambridge, 2012. Advisor: Ross Anderson, FRS. NSA AWARD FOR THE BEST SCIENTIFIC CYBERSECURITY PAPER.

Scientific instruments, scientific progress and the cyclotron

International Nuclear Information System (INIS)

Baird, David; Faust, Thomas

1990-01-01

Philosophers speak of science in terms of theory and experiment, yet when they speak of the progress of scientific knowledge they speak in terms of theory alone. In this article it is claimed that scientific knowledge consists of, among other things, scientific instruments and instrumental techniques and not simply of some kind of justified beliefs. It is argued that one aspect of scientific progress can be characterized relatively straightforwardly - the accumulation of new scientific instruments. The development of the cyclotron is taken to illustrate this point. Eight different activities which promoted the successful completion of the cyclotron are recognised. The importance is in the machine rather than the experiments which could be run on it and the focus is on how the cyclotron came into being, not how it was subsequently used. The completed instrument is seen as a useful unit of scientific progress in its own right. (UK)

Analysis of Disaster Planning in Business and Industry

Science.gov (United States)

1993-04-01

Alternatives, 13 May 1991, 1. 13. Deegan , Joseph, and Jack Jolley. "Selling Crisis Management." Security Management Jun 1985, 50. 14. Atkin, Leslie, ed. "PG... Deegan , Joseph, and Jack Jolley. "Selling Crisis Management." Security Management Jun 1985, 50. 16. Carey, John. "Getting Business to Think About the...1985, 5. 22. Aronoff, Craig E., and John L. Ward. "Why Owners Don’t Plan." Nation’s Business Jun 1990, 59. 23. Phelps, Norman L. "Setting Up a Crisis

22 CFR 171.22 - Appeals.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Appeals. 171.22 Section 171.22 Foreign Relations DEPARTMENT OF STATE ACCESS TO INFORMATION AVAILABILITY OF INFORMATION AND RECORDS TO THE PUBLIC Executive Order 12958 Provisions § 171.22 Appeals. Any denial of a mandatory declassification review request...

Novel TBX22 mutations in Chinese nonsyndromic cleft lip/palate ...

Indian Academy of Sciences (India)

Jiewen Dai

2018-06-06

Jun 6, 2018 ... sense, frame-shift, splice-site, or missense mutation (Pauws et al. 2013). Except for ... 0.4.0, http:// · frodo.wi.mit.edu/) was used for primer design. The poly- ..... Sternberg M. J. 2015 The Phyre2 web portal for protein modeling ...

Transoral approach to the craniovertebral junction Acesso transoral para a junção craniocervical

Directory of Open Access Journals (Sweden)

José Alberto Landeiro

2007-12-01

Full Text Available The transoral approach provides a safe exposure to lesions in the midline and the ventral side of the craniovertebral junction. The advantages of the transoral approach are 1 the impinging bony pathology and granulation tissue are accessible only via the ventral route; 2 the head is placed in the extended position, thus decreasing the angulation of the brainstem during the surgery; and 3 surgery is done through the avascular median pharyngeal raphe and clivus. We analyzed the clinical effects of odontoidectomy after treating 38 patients with basilar invagination. The anterior transoral operation to treat irreducible ventral compression in patients with basilar invagination was performed in 38 patients. The patients’ ages ranged from 34 to 67 years. Fourteen patients had associated Chiari malformation and eight had previously undergone posterior decompressive surgery. The main indication for surgery was significant neurological deterioration. Symptoms and signs included neck pain, myelopathy, lower cranial nerve dysfunction, nystagmus and gait disturbance. Extended exposure was performed in 24 patients. The surgery was beneficial to the majority of patients. There was one death within 10 days of surgery, due to pulmonary embolism. Postoperative complications included two cases of pneumonia, three cases of oronasal fistula with regurgitation and one cerebrospinal fluid leak. In patients with marked ventral compression, the transoral approach provides direct access to the anterior face of the craniovertebral junction and effective means for odontoidectomy.O acesso transoral é uma via direta e segura às lesões situadas na linha média e na face anterior da junção craniocervical. As vantagens do acesso transoral são as seguintes:1 a compressão óssea e o tecido de granulação localizam-se anteriormente e são accessíveis pela via anterior; 2 a cabeça do paciente é colocada em extensão, diminuindo a angulação do tronco cerebral durante

A continuous record of glacial-interglacial cycles spanning more than 500 kyr from Lake Junín, Perú

Science.gov (United States)

Rodbell, D. T.; Abbott, M. B.; McGee, D.; Chen, C. Y.; Stoner, J. S.; Hatfield, R. G.; Tapia, P. M.; Bush, M. B.; Weidhaas, N.; Woods, A.; Valero-Garces, B. L.; Lehmann, S. B.; Bustamante, M. G.; Larsen, D. J.

2017-12-01

Lake Junín (11.0°S, 76.2°W) is a shallow (zmax 12 m), intermontane, high-elevation (4080 masl) lake in the inner-tropics of the Southern Hemisphere that spans 300 km2. It is dammed by coalescing alluvial fans that are >250 ka that emanate from glacial valleys. Lake Junín has not been overrun by glacial ice in several hundred thousand years and is ideally located to receive glacigenic sediment. The Junín basin is underlain by carbonate rocks that have provided a source of Ca and HCO3 ions; precipitation of CaCO3 in the western margin of the lake during the present interglacial period has occurred at 1mm yr-1. An airgun seismic survey revealed a strong reflector at 105 meters depth, which marks the base of the lacustrine section. Drilling focused on three sites. Site 1, located near the depocenter and most distal to glacial sources, yielded a composite sediment thickness of 95m; Site 2, proximal to glacial outwash fans, yielded a composite thickness of 28 m; Site 3, located at an intermediate distance yielded a sediment thickness of 55m. The stratigraphy of Site 1 is marked by 8 glacial/interglacial cycles; the latter are characterized by low bulk density and magnetic susceptibility (MS) and high CaCO3. These units are intercalated with glacigenic sediment that has high density and MS, and low CaCO3. The age model for Site 1 is based on AMS radiocarbon dates on terrestrial macrofossils and dozens of U/Th ages on authigenic CaCO3. Strong and protracted interglacial periods appear to be associated with intervals of reduced variability of solar insolation in the Southern Hemisphere tropics. During these intervals there is strong covariation (r2>0.9) between the δ13C and δ18O of authigenic calcium carbonate, and δ18O values are relatively enriched (-12 to -2‰); examples include interglacial periods correlative with marine isotope stages (MIS) 1, 13, and 15. The magnitude of tropical glaciation appears to have been greater during glacial cycles prior to the LGM

40 CFR 81.98 - Burlington-Keokuk Interstate Air Quality Control Region.

Science.gov (United States)

2010-07-01

... Quality Control Region. 81.98 Section 81.98 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Air Quality Control Regions § 81.98 Burlington-Keokuk Interstate Air Quality Control Region. The Burlington-Keokuk Interstate Air Quality Control Region (Illinois-Iowa) is revised to consist of the...

78 FR 21946 - Request for Nominations of Candidates to the EPA's Clean Air Scientific Advisory Committee (CASAC...

Science.gov (United States)

2013-04-12

... expertise in the following disciplines: Landscape ecology; terrestrial ecology; systems ecology; and... regulation. The form may be viewed and downloaded through the ``Ethics Requirements for Advisors'' link on...

Evaluating Community Health Advisor (CHA) Core Competencies: The CHA Core Competency Retrospective Pretest/Posttest (CCCRP).

Science.gov (United States)

Story, Lachel; To, Yen M

2016-05-01

Health care and academic systems are increasingly collaborating with community health advisors (CHAs) to provide culturally relevant health interventions that promote sustained community transformation. Little attention has been placed on CHA training evaluation, including core competency attainment. This study identified common CHA core competencies, generated a theoretically based measure of those competencies, and explored psychometric properties of that measure. A concept synthesis revealed five CHA core competencies (leadership, translation, guidance, advocacy, and caring). The CHA Core Competency Retrospective Pretest/Posttest (CCCRP) resulted from that synthesis, which was administered using multiple approaches to individuals who previously received CHA training (N= 142). Exploratory factor analyses revealed a two-factor structure underlying the posttraining data, and Cronbach's alpha indicated high internal consistency. This study suggested some CHA core competencies might be more interrelated than previously thought, and two major competencies exist rather than five and supported the CCCRP's use to evaluate core competency attainment resulting from training. © The Author(s) 2014.

Man-Machine Communication in Remote Manipulation: Task-Oriented Supervisory Command Language (TOSC).

Science.gov (United States)

1980-03-01

2-32 WvNIPUa.ATY wWMj.IAYCOYOLLID 𔃾 -XNEMILPU . 310?!3us mI.I Sr 1lR ROBO ........... O4WIUVISYN CP"CRIAumaN OWW411 -femi y PACISS PSTISH ’uucomC...task description 3-15 and as a machine advisor for an apprentice. Thus, the PN are developed hierarchically, by the machine from the top down to the...96734 rs Defense Technical Information Center Dr. A. L. Slafkosky Cameron Station, Bldg. 5 Scientific Advisor Alexandria, VA 22314 (12 cys) Commandant

40 CFR 98.57 - Records that must be retained.

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2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Records that must be retained. 98.57 Section 98.57 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS...) Documentation of how process knowledge was used to estimate abatement technology destruction efficiency. (f...

40 CFR 98.214 - Monitoring and QA/QC requirements.

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2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Monitoring and QA/QC requirements. 98.214 Section 98.214 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... standard method or other enhanced industry consensus standard method published by an industry consensus...

37 CFR 1.98 - Content of information disclosure statement.

Science.gov (United States)

2010-07-01

... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Content of information disclosure statement. 1.98 Section 1.98 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES National Processing...