Factor V Leiden mutation in pregnancy.

Science.gov (United States)

Cohen, Susan Murphy

2004-01-01

Normal maternal adaptation to pregnancy significantly increases the risk for thrombus formation. Inherited thrombophilias further increase risk for deep venous thrombosis and adverse outcome in pregnancy. Factor V Leiden mutation is the most common inherited thrombophilia, occurring in approximately 5% of the White and 1% of the Black populations. Nurses should be knowledgeable about screening for and diagnosis of factor V Leiden mutation, risk reduction counseling, recommended care of the affected patient, and implications of anticoagulant therapy during the perinatal period.

21 CFR 864.7280 - Factor V Leiden DNA mutation detection systems.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Factor V Leiden DNA mutation detection systems....7280 Factor V Leiden DNA mutation detection systems. (a) Identification. Factor V Leiden deoxyribonucleic acid (DNA) mutation detection systems are devices that consist of different reagents and...

IAEA Activities in Nuclear Security, 18 April 2013, Delft, The Netherlands

International Nuclear Information System (INIS)

Amano, Y.

2013-01-01

I am pleased to take part in this event marking the launch of the new Masters Programme in Nuclear Security at the Reactor Institute Delft. The Institute has been an IAEA Collaborating Centre for nearly four years. Our two organisations have worked closely together in training and research, as well as in areas such as establishing quality management systems at nuclear analytical laboratories in IAEA Member States. The launch of the new Masters Programme in Nuclear Security by the Delft University of Technology marks a new stage in our cooperation. Four other European universities are also taking part in the programme: the University of Oslo, the Technical University of Vienna, the Brandenburg University of Applied Sciences, and the University of Manchester Dalton Nuclear Institute. I am pleased that the syllabus for the course has been developed from the IAEA's Educational Programme in Nuclear Security. I commend this effort to train a new generation of experts who can help to improve global nuclear security. Strengthening nuclear security throughout the world remains a challenge for all of us. National governments have primary responsibility for nuclear security, but international cooperation is vital.

The Delft-FEWS flow forecasting system

NARCIS (Netherlands)

Werner, M.; Schellekens, J.; Gijsbers, P.; van Dijk, M.; van den Akker, O.; Heynert, K.

2013-01-01

Since its introduction in 2002/2003, the current generation of the Delft-FEWS operational forecasting platform has found application in over forty operational centres. In these it is used to link data and models in real time, producing forecasts on a daily basis. In some cases it forms a building

Delft3D turbine turbulence module v. 1.0.0

Energy Technology Data Exchange (ETDEWEB)

2016-08-25

The DOE has funded Sandia National Labs (SNL) to develop an open-source modeling tool to guide the design and layout of marine hydrokinetic (MHK) arrays to maximize power production while minimizing environmental effects. This modeling framework simulates flows through and around a MHK arrays while quantifying environmental responses. As an augmented version of the Dutch company, Deltares’s, environmental hydrodynamics code, Delft3D, Delft3D-CEC includes a new module that simulates energy conversion (momentum withdrawal) by MHK current energy conversion devices with commensurate changes in the turbulent kinetic energy and its dissipation rate. The Following is a description of Deltares’s open-source code Delft3D from which Delft3D-CEC is built upon. “Delft3D is a world leading 3D modeling suite to investigate hydrodynamics, sediment transport and morphology and water quality for fluvial, estuarine and coastal environments. As per 1 January 2011, the Delft3D flow (FLOW), morphology (MOR) and waves (WAVE) modules are available in open source. The software is used and has proven his capabilities on many places around the world, like the Netherlands, USA, Hong Kong, Singapore, Australia, Venice, etc. The software is continuously improved and developed with innovating advanced modelling techniques as consequence of the research work of our institute and to stay world leading. The FLOW module is the heart of Delft3D and is a multi-dimensional (2D or 3D) hydrodynamic (and transport) simulation programme which calculates non-steady flow and transport phenomena resulting from tidal and meteorological forcing on a curvilinear, boundary fitted grid or sperical coordinates. In 3D simulations, the vertical grid is defined following the so-called sigma coordinate approach or Z-layer approach. The MOR module computes sediment transport (both suspended and bed total load) and morphological changes for an arbitrary number of cohesive and non-cohesive fractions. Both currents

Delft-FEWS:A Decision Making Platform to Intergrate Data, Model, Algorithm for Large-Scale River Basin Water Management

Science.gov (United States)

Yang, T.; Welles, E.

2017-12-01

In this paper, we introduce a flood forecasting and decision making platform, named Delft-FEWS, which has been developed over years at the Delft Hydraulics and now at Deltares. The philosophy of Delft-FEWS is to provide water managers and operators with an open shell tool, which allows the integratation of a variety of hydrological, hydraulics, river routing, and reservoir models with hydrometerological forecasts data. Delft-FEWS serves as an powerful tool for both basin-scale and national-scale water resources management. The essential novelty of Delft-FEWS is to change the flood forecasting and water resources management from a single model or agency centric paradigm to a intergrated framework, in which different model, data, algorithm and stakeholders are strongly linked together. The paper will start with the challenges in water resources managment, and the concept and philosophy of Delft-FEWS. Then, the details of data handling and linkages of Delft-FEWS with different hydrological, hydraulic, and reservoir models, etc. Last, several cases studies and applications of Delft-FEWS will be demonstrated, including the National Weather Service and the Bonneville Power Administration in USA, and a national application in the water board in the Netherland.

Delft Dashboard: a quick setup tool for coastal and estuarine models

Science.gov (United States)

Nederhoff, C., III; Van Dongeren, A.; Van Ormondt, M.; Veeramony, J.

2016-02-01

We developed easy-to-use Delft DashBoard (DDB) software for the rapid set-up of coastal and estuarine hydrodynamic and basic morphological numerical models. In the "Model Maker" toolbox, users have the capability to set-up Delft3D models, in a minimal amount of time (in the order of a hour), for any location in the world. DDB draws upon public internet data sources of bathymetry and tidesto construct the model. With additional toolboxes, these models can be forced with parameterized hurricane wind fields, uplift of the sea surface due to tsunamis nested in publically available ocean models and forced with meteo data (wind speed, pressure, temperature) In this presentation we will show the skill of a model which is setup with Delft Dashboard and compare it to well-calibrated benchmark models. These latter models have been set-up using detailed input data and boundary conditions. We have tested the functionality of Delft DashBoard and evaluate the performance and robustness of the DDB model system on a variety of cases, ranging from a coastal to basin models. Furthermore, we have performed a sensitivity study to investigate the most critical physical and numerical processes. The software can benefit operational modellers, as well as scientists and consultants.

TU Delft expert judgment data base

International Nuclear Information System (INIS)

Cooke, Roger M.; Goossens, Louis L.H.J.

2008-01-01

We review the applications of structured expert judgment uncertainty quantification using the 'classical model' developed at the Delft University of Technology over the last 17 years [Cooke RM. Experts in uncertainty. Oxford: Oxford University Press; 1991; Expert judgment study on atmospheric dispersion and deposition. Report Faculty of Technical Mathematics and Informatics No.01-81, Delft University of Technology; 1991]. These involve 45 expert panels, performed under contract with problem owners who reviewed and approved the results. With a few exceptions, all these applications involved the use of seed variables; that is, variables from the experts' area of expertise for which the true values are available post hoc. Seed variables are used to (1) measure expert performance, (2) enable performance-based weighted combination of experts' distributions, and (3) evaluate and hopefully validate the resulting combination or 'decision maker'. This article reviews the classical model for structured expert judgment and the performance measures, reviews applications, comparing performance-based decision makers with 'equal weight' decision makers, and collects some lessons learned

Polychaeten aus den Zoologischen Museen von Leiden und Amsterdam I

NARCIS (Netherlands)

Augener, H.

1933-01-01

In der vorliegenden Arbeit ist die Untersuchung eines sehr umfangreichen Polychaeten-Materials niedergelegt, das mir von Herrn Prof. Dr. E. D. van Oort in Leiden und Herrn Prof. Dr. L. F. de Beaufort in Amsterdam zur Bearbeitung übergeben wurde. Von diesem Material ist der dem Museum in Leiden

Comparison. US P-61 and Delft sediment samplers

Science.gov (United States)

Beverage, Joseph P.; Williams, David T.

1990-01-01

The Delft Bottle (DB) is a flow-through device designed by the Delft Hydraulic Laboratory (DHL), The Netherlands, to sample sand-sized sediment suspended in streams. The US P-61 sampler was designed by the Federal Interagency Sedimentation Project (FISP) at the St. Anthony Falls Hydraulic Laboratory, Minneapolis, Minnesota, to collect suspended sediment from deep, swift rivers. The results of two point-sampling tests in the United States, the Mississippi River near Vicksburg, Mississippi, in 1983 and the Colorado River near Blythe, California, in 1984, are provided in this report. These studies compare sand-transport rates, rather than total sediment-transport rates, because fine material washes through the DB sampler. In the United States, the commonly used limits for sand-sized material are 0.062 mm to 2.00 mm (Vanoni 1975).

Options for the Delft advanced neutron source

International Nuclear Information System (INIS)

Gibcus, H.P.M.; Leege, P.F.A. de; Labohm, F.; Vries, J.W. de; Verkooijen, A.H.M.; Valko, J.; Feltes, W.; Heinecke, J.

2003-01-01

Results of feasibility studies are presented for options for an advanced neutron source for the Delft reactor including upgrading the HOR, a 2 MW pool-type research reactor at the Delft University of Technology. The primary utilisation of the HOR focuses on beam research applications with neutrons and positrons. The aim of being scientifically competitive in that research area requires a thermal neutron flux level of at least 1x10 14 n/cm 2 /s. The feasibility of an accelerator driven neutron source and upgrading the present core to a super compact core for reaching this goal has been investigated at large from a safety and operational point of view. For the upgraded core, a 3x3 fuel assembly arrangement and beryllium reflected at all sides was chosen. Figures on the system performance, including the merits of a cold neutron source application feeding the neutron guide system, are presented. (author)

Clashes of discourses: Humanists and Calvinists in seventeenth-century academic Leiden

NARCIS (Netherlands)

Kromhout, D.

2016-01-01

Using Michel Foucault's concept of discursive change and Stephen Greenblatt's ideas about social poetics and self-fashioning, 'Clashes of Discourses: Calvinists and Humanists in Seventeenth-Century Academic Leiden' explains developments in the literary works of leading Leiden humanists against the

Weldenkende burgers en Oranjeliefhebbers. Patriotten en Prinsgezinden in Leiden, 1775-1795

NARCIS (Netherlands)

de Jong, E.H.

2014-01-01

This book deals with the conflicts between Patriots and Orangists in Leiden, which will be assessed with the help of the theory of collective action by the American sociologist Charles Tilly. The urban economy in Leiden was dominated by a textile industry that concentrated on exports and was very

Influence of the factor V Leiden mutation on infectious disease susceptibility and outcome

DEFF Research Database (Denmark)

Benfield, Thomas L; Dahl, Mortens; Nordestgaard, Borge G

2005-01-01

The effect of the coagulation factor V Leiden mutation on infectious disease susceptibility and outcome is controversial.......The effect of the coagulation factor V Leiden mutation on infectious disease susceptibility and outcome is controversial....

Sandia’s Current Energy Conversion module for the Flexible-Mesh Delft3D flow solver v. 1.0

Energy Technology Data Exchange (ETDEWEB)

2018-04-25

The DOE has funded Sandia National Labs (SNL) to develop an open-source modeling tool to guide the design and layout of marine hydrokinetic (MHK) arrays to maximize power production while minimizing environmental effects. This modeling framework simulates flows through and around a MHK arrays while quantifying environmental responses. As an augmented version of the Dutch company, Deltares’s, environmental hydrodynamics code, Delft3D, SNL-Delft3D-CEC-FM includes a new module that simulates energy conversion (momentum withdrawal) by MHK current energy conversion devices with commensurate changes in the turbulent kinetic energy and its dissipation rate. SNL-Delft3D-CEC-FM modified the Delft3D flexible mesh flow solver, DFlowFM.

CWI and TU Delft at TREC 2013: Contextual Suggestion, Federated Web Search, KBA, and Web Tracks

NARCIS (Netherlands)

A. Bellogín Kouki (Alejandro); G.G. Gebremeskel (Gebre); J. He (Jiyin); J.J.P. Lin (Jimmy); A. Said (Alan); T. Samar (Thaer); A.P. de Vries (Arjen); J.B.P. Vuurens (Jeroen)

2014-01-01

htmlabstractThis paper provides an overview of the work done at the Centrum Wiskunde & Informatica (CWI) and Delft University of Technology (TU Delft) for different tracks of TREC 2013. We participated in the Contextual Suggestion Track, the Federated Web Search Track, the Knowledge Base

The Association of Factor V Leiden Mutation with Recurrent Pregnancy Loss

International Nuclear Information System (INIS)

Kashif, M.; Saeed, A.

2015-01-01

Objective: To determine the association of factor V Leiden mutation with recurrent pregnancy loss. Methods: The case-control study was conducted at the Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from January to June 2012, and comprised women of 18 to 45 years of age who had a history of recurrent pregnancy loss, and controls with no history of pregnancy loss. All the subjects belonged to Punjabi ethnic group. Three ml blood was taken from cases and controls and deoxyribonucleic acid was extracted. In order to identify Factor V Leiden mutation, polymerase chain reaction method was utilised combined with the amplification refractory mutation system. Data was analysed using SPSS 17. Results: Of the 112 subjects, 56(50 percent) were in each of the two groups. The presence of factor V Leiden mutation among the cases was 3(5.4 percent) while it was absent among the controls. The mutation was significantly associated with recurrent pregnancy loss (p=0.017).Recurrent pregnancy loss was higher in cases than controls (p=0.001). Conclusion: Factor V Leiden mutation was significantly associated with recurrent pregnancy loss. It should be considered one of the causes of recurrent pregnancy loss. (author)

Fire and collapse, Faculty of Architecture building, Delft University of Technology: Data collection and preliminary analyses

NARCIS (Netherlands)

Meacham, B.; Park, H.; Engelhardt, M.; Kirk, A.; Kodur, V.; Straalen, IJ.J.; Maljaars, J.; Weeren, K. van; Feijter, R. de; Both, K.

2010-01-01

On the morning of May 13, 2008, a fire that started in a coffee vending machine on the 6th floor of the 13-story Faculty of Architecture Building at the Delft University of Technology (TUD), Delft, the Netherlands, quickly developed into an extreme loading event. Although all building occupants

Collaboration of the Dutch research program for radioactive waste disposal (OPERA) and TU Delft

International Nuclear Information System (INIS)

Bykov, D.M.; Kloosterman, J.L.

2015-01-01

awarded research proposals available at www.covra.nl/downloads/o pera. Building up competences and knowledge on radioactive waste management and geological disposal is an important goal of OPERA. To this end OPERA collaborates with TU Delft to develop an academic curriculum for the chair Chemistry of the Nuclear Fuel Cycle in the Master of Science Engineering. Furthermore, the results obtained in OPERA will be presented at a Summer School which is planned to be organized at the end of the Program. TU Delft educates young specialists, bachelor and master students, by research projects on geological disposal at the new actinide laboratory (U and Th). For such purpose the knowledge transfer from other OPERA partners is also foreseen, including students internships and visits of the research facilities. Reactor Institute Delft (RID) is part of the Applied Sciences faculty of TU Delft and houses the Radiation Science and Technology (RST) department. RID operates the Hoger Onderwijs Reactor (HOR), a 2 MW pool- type research reactor in an academic setting. The reactor is used as a source of neutrons and positrons for research purposes, including those of OPERA. It also provides neutrons to a variety of facilities for radioisotope production and neutron activation analysis. OPERA is financed by the Dutch Ministry of Economic Affairs and the public limited liability company Elektriciteits-Produktiemaatschappij Zuid-Nederland (EPZ) and coordinated by COVRA.

Collaboration of the Dutch research program for radioactive waste disposal (OPERA) and TU Delft

Energy Technology Data Exchange (ETDEWEB)

Bykov, D.M.; Kloosterman, J.L. [TU Delft (Netherlands). Reactor Inst. Delft; Neeft, E.A.C.; Verhoef, E.V. [COVRA N.V., Nieuwdorp (Netherlands)

2015-07-01

awarded research proposals available at www.covra.nl/downloads/o pera. Building up competences and knowledge on radioactive waste management and geological disposal is an important goal of OPERA. To this end OPERA collaborates with TU Delft to develop an academic curriculum for the chair Chemistry of the Nuclear Fuel Cycle in the Master of Science Engineering. Furthermore, the results obtained in OPERA will be presented at a Summer School which is planned to be organized at the end of the Program. TU Delft educates young specialists, bachelor and master students, by research projects on geological disposal at the new actinide laboratory (U and Th). For such purpose the knowledge transfer from other OPERA partners is also foreseen, including students internships and visits of the research facilities. Reactor Institute Delft (RID) is part of the Applied Sciences faculty of TU Delft and houses the Radiation Science and Technology (RST) department. RID operates the Hoger Onderwijs Reactor (HOR), a 2 MW pool- type research reactor in an academic setting. The reactor is used as a source of neutrons and positrons for research purposes, including those of OPERA. It also provides neutrons to a variety of facilities for radioisotope production and neutron activation analysis. OPERA is financed by the Dutch Ministry of Economic Affairs and the public limited liability company Elektriciteits-Produktiemaatschappij Zuid-Nederland (EPZ) and coordinated by COVRA.

Progression and regression of atherosclerosis in APOE3-Leiden transgenic mice : An immunohistochemical study

NARCIS (Netherlands)

Gijbels, M.J.J.; Cammen, M. van der; Laan, L.J.W. van der; Emeis, J.J.; Havekes, L.M.; Hofker, M.H.; Kraal, G.

1999-01-01

Apolipoprotein E3-Leiden (APOE3-Leiden) transgenic mice develop hyperlipidemia and are highly susceptible to diet-induced atherosclerosis. We have studied the progression and regression of atherosclerosis using immunohistochemistry. Female transgenic mice were fed a moderate fat diet to study

Mechanisms of the factor V Leiden paradox

NARCIS (Netherlands)

van Stralen, K. J.; Doggen, C. J. M.; Bezemer, I. D.; Pomp, E. R.; Lisman, T.; Rosendaal, F. R.

2008-01-01

Objective-Carriers of the factor V Leiden mutation (FVL-carriers) have a substantially increased risk of deep venous thrombosis (DVT), whereas the risk of pulmonary embolism (PE) is only mildly increased compared with noncarriers. So far few studies have investigated possible mechanisms for this

Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice

NARCIS (Netherlands)

Winther, M.P.J. de; Gijbels, M.J.J.; Dijk, K.W. van; Gorp, P.J.J. van; Suzuki, H.; Kodama, T.; Frants, R.R.; Havekes, L.M.; Hofker, M.H.

1999-01-01

Apolipoprotein (apo) E3Leiden is a dysfunctional apo E variant associated with familial dysbetalipoproteinemia in humans. Transgenic mice carrying the APOE3Leiden gene develop hyperlipidemia and are highly susceptible to diet-induced atherosclerosis. An early step in atherosclerosis is foam cell

Ruimtelijke transformaties van de steden in het Randstadgebied (12de-20ste eeuw) : Een vergelijkende analyse van de stadsplattegronden

NARCIS (Netherlands)

Zweerink, K.A.

2017-01-01

In this study, the transformation of the form of nine cities in the Randstad between 1250 and 1940 in relation to changes in infrastructure is central, namely Utrecht, Dordrecht, Leiden, Haarlem, Delft, Gouda, Amsterdam, Rotterdam and The Hague. Within this time span three periods of great spatial

Patient experiences with self-monitoring renal function after renal transplantation: results from a single-center prospective pilot study

Directory of Open Access Journals (Sweden)

van Lint CL

2015-12-01

Full Text Available Céline L van Lint,1 Paul JM van der Boog,1 Wenxin Wang,2,3 Willem-Paul Brinkman,2 Ton JM Rövekamp,3 Mark A Neerincx,2 Ton J Rabelink,1 Sandra van Dijk1,4 1Department of Nephrology, Leiden University Medical Centre (LUMC, Leiden, 2Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology, Delft, 3Department of Technology in Healthcare, Prevention and Health, Dutch Organization for Applied Scientific Research (TNO, Leiden, 4Department of Health, Medical and Neuropsychology, Faculty of Social and Behavioural Sciences, Leiden University, Leiden, the Netherlands Background: After a kidney transplantation, patients have to visit the hospital often to monitor for early signs of graft rejection. Self-monitoring of creatinine in addition to blood pressure at home could alleviate the burden of frequent outpatient visits, but only if patients are willing to self-monitor and if they adhere to the self-monitoring measurement regimen. A prospective pilot study was conducted to assess patients’ experiences and satisfaction.Materials and methods: For 3 months after transplantation, 30 patients registered self-measured creatinine and blood pressure values in an online record to which their physician had access to. Patients completed a questionnaire at baseline and follow-up to assess satisfaction, attitude, self-efficacy regarding self-monitoring, worries, and physician support. Adherence was studied by comparing the number of registered with the number of requested measurements.Results: Patients were highly motivated to self-monitor kidney function, and reported high levels of general satisfaction. Level of satisfaction was positively related to perceived support from physicians (P<0.01, level of self-efficacy (P<0.01, and amount of trust in the accuracy of the creatinine meter (P<0.01. The use of both the creatinine and blood pressure meter was considered pleasant and useful, despite the level of trust in the

English Language Screening for Scientific Staff at Delft University of Technology,

NARCIS (Netherlands)

Klaassen, R.G.; Bos, M.H.P.C.

2010-01-01

Delft University of Technology (DUT) screened her (non-native English) scientific staff on their level of English proficiency in the academic year of 2006/2007. In this paper this large scale operation, involving planning, policy decisions, assessment means, advice and training are discussed. Since

Survey of HTR related research at IRI, Delft, Netherlands

Energy Technology Data Exchange (ETDEWEB)

Hoogenboom, J.E.; Wallerbos, E.J.M.; Van der Hagen, T.H.J.J.; Van Dam, H. [Interfaculty Reactor Institute IRI, Delft University of Technology, Delft (Netherlands); Tuerkcan, E. [ECN Nuclear Research, Petten (Netherlands)

1998-09-01

High temperature helium-cooled reactors have a large potential for inherent safety. Therefore, several projects on HTR research are being carried out or were carried out at the Interfaculty Reactor Institute (IRI) of the Delft University of Technology in Delft, Netherlands. As part of a larger research programme measurements of core reactivity, reactivity worth of safety rods and of small samples being oscillated in the reactor core were carried out at the PROTEUS facility of the Paul Scherrer Institute at Villigen, Switzerland. Together with other partners in the Netherlands a small inherently safe co-generation plant with a pebble-bed HTR core was designed and analysed. It was verified that such a reactor can operate continuously for 10 years by adding continuously fuel pebbles until the maximum available core height is reached. As a new, innovative, inherently safe reactor type the design of a fluidized-bed reactor with coated fuel particles on a helium gas stream is discussed and results are shown for the analysis of inherent criticality safety under varying coolant flow rates. IRI is also taking part in the new IAEA Co-ordinated Research Programme, which involves participation in the start-up experiments of the Japanese HTTR and carrying out calculations for the core physics benchmark test. 11 refs.

Dirc van Delfts Tafel van den Kersten Ghelove en de stervensliteratuur

DEFF Research Database (Denmark)

Robbe, Joost Roger

2015-01-01

treatise, Dirc van Delft presents a veritable ars moriendi which provides practical guidance for the dying and those attending them. The treatise culminates in a vivid drama in which the soul, being subject to three temptations of the devil, can benefit from the protection of its guardian angel as well...

Going Dutch: Higher Education in the Netherlands

Science.gov (United States)

Law, David

2016-01-01

This article outlines some of the policy issues currently faced by research-based universities in the Netherlands. The focus is on four leading universities (University of Amsterdam: UvA; Free University of Amsterdam: VU; Leiden University; and Delft University of Technology: TUD). The author visited these institutions as part of a Study Tour…

Evaluation the frequency of factor V Leiden mutation in pregnant women with preeclampsia syndrome in an Iranian population

Directory of Open Access Journals (Sweden)

Azadeh Azinfar

2012-01-01

Full Text Available Background: Role of genetic factors in etiology of preeclampsia is not confirmed yet.Objective: Gene defect frequency varies in different geographic areas as well as ethnic groups. In this study, the role of factor V Leiden mutation in the pathogenesis of preeclampsia syndrome among the pregnant population of northern shore of Persian Gulf in Iran, were considered.Materials and Methods: Between Jan. 2008 and Dec. 2009, in a nested case control study, pregnant women with preeclampsia (N=198 as cases and healthy (N=201 as controls were enrolled in the study. DNA were extracted from 10 CC peripheral blood and analyzed for presence of factor V Leiden mutation in these subjects. The maternal and neonatal outcomes of pregnancy according to the distribution of factor V Leiden were also compared among cases.Results: In total, 17(8.6% of cases and 2(1% of controls showed the factor V Leiden mutation. The incidence of factor V Leiden was typically higher in preeclamptic women than control group (OR: 9.34 %95 CI: 2.12-41.01. There was no difference in incidence rate of preterm delivery< 37 weeks (OR: 1.23 %95 CI: 0.38-4.02, very early preterm delivery<32 weeks (OR: 1.00 %95 CI: 0.12-8.46, intra uterine fetal growth restriction (IUGR (OR: 1.32 %95 CI: 0.15-11.30 ,and the rate of cesarean section (OR: 0.88 %95 CI: 0.29-2.62 among cases based on the prevalence of factor V Leiden mutation.Conclusion: The pregnant women with factor V Leiden mutation are prone for preeclampsia syndrome during pregnancy, but this risk factor was not correlated to pregnancy complications in the studied women

You can't just blame the crocodile : Delft engineers travel into sustainability

NARCIS (Netherlands)

Van der Sanden, M.C.A., et al

2007-01-01

This book contains stories of young people who made a journey into sustainability. It is about engineers from TU Delft and the inspiration they derived from the people they met and the projects they have seen throughout the world. It is about construction, sanitation, mobile networks,

The cover stars of Nature and Science

NARCIS (Netherlands)

Dekker, N.; Mooij, H.; Kouwenhoven, L.; Vermeersen, B.; Riva, R.; Dekker, C.; Godfroy, F.

For the nano-scientists at the Faculty of Applied Sciences, having their articles published in prestigious journals like Nature and Science is no longer all that special these days. The TU Delft physicists have been publishing virtually non-stop in what are regarded as the best science journals in

Note sur les Buprestides du Museum de Leiden

NARCIS (Netherlands)

Thery, A.

1935-01-01

M. le Dr. H. C. Blöte, entomologiste du Rijksmuseum van Natuurlijke Historie à Leiden (Hollande) m'a confié l'étude de matériaux indéterminés appartenant aux collections de cet établissement, parmi ceux-ci j'ai trouvé quelques espèces nouvelles dont je donne ci-dessous la description. Les types de

Essential Skills for System Dynamics Practitioners : A Delft University of Technology Perspective

NARCIS (Netherlands)

Meyers, W.K.; Slinger, J.H.; Pruyt, E.; Yucel, G.; Van Daalen, C.

2010-01-01

There is little consensus on the skills set required of a system dynamics practitioner. In this paper we use the teaching approach and learning goals of the system dynamics courses at the Delft University of Technology as a starting point to explore the development of system dynamics modeling

Factor V Leiden is associated with increased sperm count

NARCIS (Netherlands)

van Mens, T. E.; Joensen, U. N.; Bochdanovits, Z.; Takizawa, A.; Peter, J.; Jørgensen, N.; Szecsi, P. B.; Meijers, J. C. M.; Weiler, H.; Rajpert-de Meyts, E.; Repping, S.; Middeldorp, S.

2017-01-01

STUDY QUESTION: Is the thrombophilia mutation factor V Leiden (FVL) associated with an increased total sperm count? SUMMARY ANSWER: Carriers of FVL have a higher total sperm count than non-FVL-carriers, which could not be explained by genetic linkage or by observations in a FVL-mouse model. WHAT IS

Fuel shuffling optimization for the Delft research reactor

Energy Technology Data Exchange (ETDEWEB)

Geemert, R. van; Hoogenboom, J.E.; Gibcus, H.P.M. [Delft Univ. of Technology, Interfaculty Reactor Inst., Delft (Netherlands); Quist, A.J. [Delft Univ., Fac. of Applied Mathematics and Informatics, Delft (Netherlands)

1997-07-01

A fuel shuffling optimization procedure is proposed for the Hoger Onderwijs Reactor (HOR) in Delft, the Netherlands, a 2 MWth swimming-pool type research reactor. In order to cope with the fluctuatory behaviour of objective functions in loading pattern optimization, the proposed cyclic permutation optimization procedure features a gradual transition from global to local search behaviour via the introduction of stochastic tests for the number of fuel assemblies involved in a cyclic permutation. The possible objectives and the safety and operation constraints, as well as the optimization procedure, are discussed, followed by some optimization results for the HOR. (author) 5 figs., 4 refs.

Fuel shuffling optimization for the Delft research reactor

International Nuclear Information System (INIS)

Geemert, R. van; Hoogenboom, J.E.; Gibcus, H.P.M.; Quist, A.J.

1997-01-01

A fuel shuffling optimization procedure is proposed for the Hoger Onderwijs Reactor (HOR) in Delft, the Netherlands, a 2 MWth swimming-pool type research reactor. In order to cope with the fluctuatory behaviour of objective functions in loading pattern optimization, the proposed cyclic permutation optimization procedure features a gradual transition from global to local search behaviour via the introduction of stochastic tests for the number of fuel assemblies involved in a cyclic permutation. The possible objectives and the safety and operation constraints, as well as the optimization procedure, are discussed, followed by some optimization results for the HOR. (author)

Fuel shuffling optimization for the Delft research reactor

Energy Technology Data Exchange (ETDEWEB)

Geemert, R. van; Hoogenboom, J.E.; Gibcus, H.P.M. [Delft Univ. of Technology, Interfaculty Reactor Inst., Delft (Netherlands); Quist, A.J. [Delft Univ., Fac. of Applied Mathematics and Informatics, Delft (Netherlands)

1997-07-01

A fuel shuffling optimization procedure is proposed for the Hoger Onderwijs Reactor (HOR) in Delft, the Netherlands, a 2 MWth swimming-pool type research reactor. In order to cope with the fluctuatory behaviour of objective functions in loading pattern optimization, the proposed cyclic permutation optimization procedure features a gradual transition from global to local search behaviour via the introduction of stochastic tests for the number of fuel assemblies involved in a cyclic permutation. The possible objectives and the safety and operation constraints, as well as the optimization procedure, are discussed, followed by some optimization results for the HOR. (author)

Apolipoprotein E*3-Leiden transgenic mice mode for hypolipidaemic drugs

NARCIS (Netherlands)

Vlijmen, B.J.M. van; Pearce, N.J.; Bergö, M.; Staels, B.; Yates, J.W.; Gribble, A.D.; Bond, B.C.; Hofker, M.H.; Havekes, L.M.; Groot, P.H.E.

1998-01-01

Apolipoprotein (APO) E*3-Leiden mice with impaired chylomicron and VLDL (very low density lipoprotein) remnant metabolism display hyperlipidaemia and atherosclerosis. In the present study, these mice were used for testing the hypolipidaemic effect of two marketed agents, lovastatin (CAS 75330-75-5)

Growth in The Hague versus decline in Leiden. A comparison of spatial development in two Dutch cities between 1700 and 1870

Directory of Open Access Journals (Sweden)

Jelmer van der Zweep

2017-04-01

1830–1870 The Hague underwent considerable densification inside the canal ring as well as extensions north and south of the city. The number of new tenements built on inner yards in The Hague can give a distorted impression, as can the number of demolished buildings in Leiden, because the 1870 maps were much more detailed. In Leiden the advent of new factories prompted new construction on the former city walls. The Hague, too, became a major industrial player, while continuing to profit from its function as the centre of government. In 1870, The Hague had almost twoand-a-half times as many inhabitants as Leiden (92,000 versus 39,000, but within the canal girdle Leiden was still more densely built up. Between 1700 and 1870, The Hague developed into one of the Netherlands’ biggest cities, which it still is. Leiden plummeted from second place to the middle bracket, where it continues to sit today.

Indigenous Peoples : Local Impacts of International Rights. Valedictory Lecture Leiden University

NARCIS (Netherlands)

Persoon, G.A.

2017-01-01

Valedictory lecture given by Prof.dr. Gerard A. Persoon Professor of Environment and Development and in particular Indigenous Peoples in Southeast Asia at Leiden University on Monday, October 23 2017Museum Volkenkunde / Ethnographic Museum

Indigenous Peoples: Local Impacts of International Rights. Valedictory Lecture Leiden University

OpenAIRE

Persoon, G.A.

2017-01-01

Valedictory lecture given by Prof.dr. Gerard A. Persoon Professor of Environment and Development and in particular Indigenous Peoples in Southeast Asia at Leiden University on Monday, October 23 2017Museum Volkenkunde / Ethnographic Museum

Hop, Step, Step and Jump : Towards Real-World Complexity @ Delft University of Technology

NARCIS (Netherlands)

Pruyt, E.; Slinger, J.H.; Van Daalen, C.; Yucel, G.; Thissen, W.A.H.

2009-01-01

This paper deals with System Dynamics education at Delft University of Technology, the Netherlands. It focuses more specifically on the quadruple jump approach towards dealing with real-world dynamic complexity. The paper starts with an overview of the System Dynamics courses, situated within the

Reconstructing the Middle Ages. Dirck van Bleyswijck’s Beschryvinge der stadt Delft and its uneasy relationship with the past

Directory of Open Access Journals (Sweden)

Marcin Polkowski

2013-12-01

Full Text Available Dirck van Bleyswijck's Beschryvinge der stadt Delft presents an ambiguous and problematic attitude to the medieval history of Delft, which makes it interesting to scholars wishing to explore the perception of the Middle Ages as it crystallized during the early modern period. The aim of this contribution is to determine the intellectual origins of Van Bleyswijck's work as a historian in the context of his perception of the medieval past. The analysis of Van Bleyswijck's performance as a historian is based on a case study derived from the narrative: quotations from source texts and commentary about the life of the medieval Delft beguine Geertruyd van Oosten will be compared. Van Bleyswijck's representation of the Middle Ages was formed by a combination of humanist and proto-Enlightenment concepts, which entailed a critical reaction to forms of religious culture known to medieval society.

Teaching Sustainable Entrepreneurship to Engineering Students: The Case of Delft University of Technology

Science.gov (United States)

Bonnet, Hans; Quist, Jaco; Hoogwater, Daan; Spaans, Johan; Wehrmann, Caroline

2006-01-01

Sustainability, enhancement of personal skills, social aspects of technology, management and entrepreneurship are of increasing concern for engineers and therefore for engineering education. In 1996 at Delft University of Technology this led to the introduction of a subject on sustainable entrepreneurship and technology in the course programmes of…

Verzeichnis der Echiuridae, Sipunculidae und Priapulidae des Naturhistorichen Reichsmuseums in Leiden

NARCIS (Netherlands)

Stiasny, G.

1930-01-01

Die vorliegende Mitteilung ist das Ergebnis der Bearbeitung zumeist älteren Materiales an Echiuriden, Sipunculiden und Priapuliden des Naturhistorischen Reichs-Museums in Leiden. Obwohl die Sammlung nach Anzahl der Exemplare nicht umfangreich ist, zeigt sie einen überraschenden Reichtum an Formen

Differential effects of amlodipine and atorvastatin treatment and their combination on atherosclerosis in ApoE*3-Leiden transgenic mice

NARCIS (Netherlands)

Delsing, D.J.; Jukema, J.W.; van de Wiel, M.A.; Emeis, J.; van der Laarse, A.; Havekes, L.M.; Princen, H.M.G.

2003-01-01

This study was designed to investigate the potential antiatherosclerotic effects of the calcium antagonist amlodipine as compared with the HMG-CoA reductase inhibitor atorvastatin and the combination of both in ApoE*3-Leiden transgenic mice. Four groups of 15 ApoE*3-Leiden mice were put on a

A half century of abstracting at the African Studies Centre Leiden

NARCIS (Netherlands)

Doorn, van M.C.A.

2013-01-01

The article discusses the history of the abstracts and indexing journal originally known as 'Documentatieblad,' which was renamed to 'African Studies Abstracts (ASA)' and later to 'African Studies Abstracts Online' (ASAO), published by the African Studies Centre (ASC) in Leiden, the Netherlands

One Thousand Flowers in Delft: A Bottom-up approach to improve teaching international students

NARCIS (Netherlands)

Brummelink, M.L.; Frantzeskaki, N.; Klaassen, R.G.; Blom, E.M.; Kooij, R.E.; Kroesen, J.O.; Stadler D.I.; Boogaard, M.E.D. van den

2009-01-01

Delft University of Technology (DUT) is becoming more and more an international community. Since lectures on master level are all conducted in English, the numbers of students from foreign countries attending DUT are rising and international cooperation within educational projects is a necessity. To

One Thousand Flowers in Delft : A Bottom-up approach to improve teaching international students

NARCIS (Netherlands)

Brummelink, M.L.; Frantzeskaki, N.; Klaassen, R.G.; Blom, E.M.; Kooij, R.E.; Kroesen, J.O.; Stadler, D.I.; Van den Boogaard, M.E.D.

2009-01-01

Delft University of Technology (DUT) is becoming more and more an international community. Since lectures on master level are all conducted in English, the numbers of students from foreign countries attending DUT are rising and international cooperation within educational projects is a necessity. To

Meta-analysis of factor V Leiden and ischemic stroke in young adults: the importance of case ascertainment.

Science.gov (United States)

Hamedani, Ali G; Cole, John W; Mitchell, Braxton D; Kittner, Steven J

2010-08-01

The factor V Leiden mutation is associated with ischemic stroke in children but not in adults. Whether it is associated with ischemic stroke in young adults, however, is uncertain. To address this issue, we performed a meta-analysis of 18 case-control studies of ischemic stroke in adults 50 years of age and younger published before June 2009. Across all studies, factor V Leiden was detected in 154 of 2045 cases (7.5%) and 217 of 5307 controls (4.1%), yielding a fixed-effect odds ratio of 2.00 (95% CI, 1.59-2.51). However, further analyses revealed substantial heterogeneity among these studies (P=0.005 for Q-test of heterogeneity). Hypothesizing that this heterogeneity could be related to differences among studies in case selection criteria, we stratified the meta-analysis into studies for which case samples were enriched or not enriched to include cases having an increased likelihood of prothrombotic genetic involvement ("selected" ischemic stroke studies, n=9) and those that recruited cases from consecutive neurology referrals or hospitalizations ("unselected" ischemic stroke studies, n=8). Among the 9 "selected" ischemic stroke studies, factor V Leiden was more strongly associated with stroke (OR, 2.73; 95% CI, 1.98-3.75), whereas among the 8 "unselected" ischemic stroke studies, the association between factor V Leiden and stroke was substantially weaker (OR, 1.40; 95% CI, 0.998-1.95). This difference was found to be statistically significant (P=0.003 for Woolf test for heterogeneity). We conclude that factor V Leiden is associated with ischemic stroke in young adults, particularly in patient populations in which there is an increased clinical suspicion of prothrombotic state.

Key Inflammatory Processes in Human NASH Are Reflected in Ldlr-/-.Leiden Mice: A Translational Gene Profiling Study.

Science.gov (United States)

Morrison, Martine C; Kleemann, Robert; van Koppen, Arianne; Hanemaaijer, Roeland; Verschuren, Lars

2018-01-01

Introduction: It is generally accepted that metabolic inflammation in the liver is an important driver of disease progression in NASH and associated matrix remodeling/fibrosis. However, the exact molecular inflammatory mechanisms are poorly defined in human studies. Investigation of key pathogenic mechanisms requires the use of pre-clinical models, for instance for time-resolved studies. Such models must reflect molecular disease processes of importance in patients. Herein we characterized inflammation in NASH patients on the molecular level by transcriptomics and investigated whether key human disease pathways can be recapitulated experimentally in Ldlr -/- .Leiden mice, an established pre-clinical model of NASH. Methods: Human molecular inflammatory processes were defined using a publicly available NASH gene expression profiling dataset (GSE48452) allowing the comparison of biopsy-confirmed NASH patients with normal controls. Gene profiling data from high-fat diet (HFD)-fed Ldlr -/- .Leiden mice (GSE109345) were used for assessment of the translational value of these mice. Results: In human NASH livers, we observed regulation of 65 canonical pathways of which the majority was involved in inflammation (32%), lipid metabolism (16%), and extracellular matrix/remodeling (12%). A similar distribution of pathways across these categories, inflammation (36%), lipid metabolism (24%) and extracellular matrix/remodeling (8%) was observed in HFD-fed Ldlr -/- .Leiden mice. Detailed evaluation of these pathways revealed that a substantial proportion (11 out of 13) of human NASH inflammatory pathways was recapitulated in Ldlr -/- .Leiden mice. Furthermore, the activation state of identified master regulators of inflammation (i.e., specific transcription factors, cytokines, and growth factors) in human NASH was largely reflected in Ldlr -/- .Leiden mice, further substantiating its translational value. Conclusion: Human NASH is characterized by upregulation of specific

Antony van Leeuwenhoek's microscopes and other scientific instruments: new information from the Delft archives

NARCIS (Netherlands)

Zuidervaart, Huib J.

2016-01-01

This paper discusses the scientific instruments made and used by the microscopist Antony van Leeuwenhoek (1632–1723). The immediate cause of our study was the discovery of an overlooked document from the Delft archive: an inventory of the possessions that were left in 1745 after the death of

Prevalentie van chronische-vermoeidheidsyndroom in 4 huisartspraktijken in de regio Leiden [Prevalence of chronic fatigue syndrome in four general practices in Leyden region

NARCIS (Netherlands)

Versluis, R.G.J.A.; Waal, M.W.M. de; Opmeer, C.; Petri, H.; Springer, M.P.

1997-01-01

Doel. De prevalentie vaststellen van chronische-vermoeidheidsyndroom (CVS) in de huisartspraktijk. Opzet. Descriptief. Plaats. Huisartspraktijken in Leiden en omstreken. Methode. Het geanonimiseerde geautomatiseerde databestand van het Registratie Netwerk Universitaire Huisartspraktijken Leiden en

Key Inflammatory Processes in Human NASH Are Reflected in Ldlr−/−.Leiden Mice: A Translational Gene Profiling Study

Science.gov (United States)

Morrison, Martine C.; Kleemann, Robert; van Koppen, Arianne; Hanemaaijer, Roeland; Verschuren, Lars

2018-01-01

Introduction: It is generally accepted that metabolic inflammation in the liver is an important driver of disease progression in NASH and associated matrix remodeling/fibrosis. However, the exact molecular inflammatory mechanisms are poorly defined in human studies. Investigation of key pathogenic mechanisms requires the use of pre-clinical models, for instance for time-resolved studies. Such models must reflect molecular disease processes of importance in patients. Herein we characterized inflammation in NASH patients on the molecular level by transcriptomics and investigated whether key human disease pathways can be recapitulated experimentally in Ldlr−/−.Leiden mice, an established pre-clinical model of NASH. Methods: Human molecular inflammatory processes were defined using a publicly available NASH gene expression profiling dataset (GSE48452) allowing the comparison of biopsy-confirmed NASH patients with normal controls. Gene profiling data from high-fat diet (HFD)-fed Ldlr−/−.Leiden mice (GSE109345) were used for assessment of the translational value of these mice. Results: In human NASH livers, we observed regulation of 65 canonical pathways of which the majority was involved in inflammation (32%), lipid metabolism (16%), and extracellular matrix/remodeling (12%). A similar distribution of pathways across these categories, inflammation (36%), lipid metabolism (24%) and extracellular matrix/remodeling (8%) was observed in HFD-fed Ldlr−/−.Leiden mice. Detailed evaluation of these pathways revealed that a substantial proportion (11 out of 13) of human NASH inflammatory pathways was recapitulated in Ldlr−/−.Leiden mice. Furthermore, the activation state of identified master regulators of inflammation (i.e., specific transcription factors, cytokines, and growth factors) in human NASH was largely reflected in Ldlr−/−.Leiden mice, further substantiating its translational value. Conclusion: Human NASH is characterized by upregulation of specific

Creating the integral engineer : Combining development education, sustainability, entrepreneurship and technology at Delft University of Technology

NARCIS (Netherlands)

Zwarteveen, J.W.; Blom, E.M.; Vastbinder, B.; Brezet, J.C.

2010-01-01

A modern engineer is more than a technical specialist. Training an integral engineer requires education in non-technical skills, including social and ethical aspects. Therefore, Delft University of Technology (DUT) introduced sustainable development and entrepreneurship into its bachelor and master

Factor V G1691A (Leiden is a major etiological factor in Egyptian Budd-Chiari syndrome patients

Directory of Open Access Journals (Sweden)

Tawhida Y. Abdel Ghaffar

2011-12-01

Full Text Available Objective: Budd-Chiari syndrome is a multifactorial disease in which several prothrombotic disorders may predispose patients to the development of thrombosis at this uncommon location (hepatic veins. The aim of this study was to determine the prevalence and characteristics of inherited thrombophilia in Egyptian Budd-Chiari syndrome patients.Materials and Methods: The study included 47 Budd-Chiari syndrome patients (20 children and 27 adults. Genotyping of Factor V G1691A (Leiden, prothrombin G20210A (PT, and methylenetetrahydrofolate reductase C677T were performed using real-time PCR and fluorescence melting curve detection analysis.Results: Factor V Leiden was observed in 29 patients (61.7%. It is the only factor that caused Budd-Chiari syndrome in 18 of the patients and in 5 of the patients with inferior vena cava involvement. Myeloproliferative disease was noted in 12 (25.5% patients, antiphospholipid syndrome in 5 (10.6%, and Behcet’s disease in 3 (6.4%. Interestingly, 3 of the children with Budd-Chiari syndrome had lipid storage disease.Conclusion: Factor V Leiden was a major etiological factor in Egyptian Budd-Chiari syndrome patients, which may have been related to the high frequency of this mutation in the study region. Factor V Leiden was also a strong thrombophilic factor and the leading cause of inferior vena cava thrombosis in these patients. Lipid storage disease should be included as a risk factor for Budd-Chiari syndrome.

Gewenst beleid tegen ongewenst gedrag : onveiligheid binnen de organisatie kan leiden tot ziekteverzuim

NARCIS (Netherlands)

Dalen, E.J. van; Nuyens, M.

2005-01-01

Indimidatie en agressie en geweld op het werk kunnen leiden tot gevoelens van onveiligheid en ziekteverzuim. Bepalingen in de Arbowet hebben onvoldoende effect op beleidsvorming ter voorkoming van ongewenste omgangsvormen. Goede praktijkvoorbeelden van beleid tegen ongewenst gedrag kunnen

Die Scyphomedusen-Sammlung des Naturhistorischen Reichsmuseums in Leiden : II. Stauromedusae, Coronatae, Semaeostomeae

NARCIS (Netherlands)

Stiasny, G.

1919-01-01

ALLGEMEINER TEIL. Die Bearbeitung der umfangreichen Scyphomedusen-Sammlung im Rijksmuseum van Natuurlijke Historie in Leiden ist nunmehr so weit vorgeschritten, dass sich eine Übersicht über dieselbe gewinnen lässt. In einer früheren Mitteilung wurde über die Cubomedusen berichtet, eine weitere zur

Multi-beam neutron guide system at IRI, Delft

Energy Technology Data Exchange (ETDEWEB)

Well, A.A. van; Gibcus, H.P.M.; Gommers, R.M.; Haan, V.O. de; Labohm, F.; Verkooijen, A.H.M. [Technische Univ. Delft (Netherlands). Interfacultair Reactor Inst.; Schebetov, A.; Pusenkov, V. [St. Petersburg Inst. of Nuclear Physics, Gatchina (Russian Federation)

2001-07-01

One of the main facilities of the Interfaculty Reactor Institute (IRI) at the Delft University of Technology is the swimming-pool type research reactor HOR. In 1963 it was critical for the first time. The power raised from 100 kW in 1963 to 500 kW in 1965. In 1968, forced cooling was introduced. From that time on, the reactor is operated at 2 MW, 5 days per week. The reactor comprises a variety of irradiation facilities, used among others for radioisotope production and neutron activation analysis. It is equipped with six horizontal radial beam tubes, originally used for neutron-scattering experiments. Throughout the years, the research activities have grown steadily, both in the development of new techniques and in applying these techniques in new research areas. (orig.)

Orthopterological notes I : On the Lesini of the Leiden Museum (Tettigoniidae, Copiphorinae)

NARCIS (Netherlands)

Jong, de C.

1942-01-01

When rearranging a part of the collections of Orthoptera in the Rijksmuseum van Natuurlijke Historie at Leiden I found a number of specimens belonging to this tribus, which by former authors is considered as a separate subfamily with the name Eumegalodontinae (Kirby, 1906, p. 289; Caudell, 1927, p.

Increased sperm count may account for high population frequency of factor V Leiden

NARCIS (Netherlands)

Cohn, D. M.; Repping, S.; Büller, H. R.; Meijers, J. C. M.; Middeldorp, S.

2010-01-01

Background: Factor V Leiden (FVL) increases the risk of venous thrombosis and pregnancy loss in carriers. Nevertheless, this relatively old mutation is prevalent in Caucasion populations, which could be explained by positive selection pressure. Men with FVL have previously been found to have higher

CETP does not affect triglyceride production or clearance in APOE*3-Leiden mice

NARCIS (Netherlands)

Bijland, S.; Berg, S.A.A. van den; Voshol, P.J.; Hoek, A.M. van den; Princen, H.M.G.; Havekes, L.M.; Rensen, P.C.N.; Dijk, K.W. van

2010-01-01

The cholesteryl ester transfer protein (CETP) facilitates the bidirectional transfer of cholesteryl esters and triglycerides (TG) between HDL and (V)LDL. By shifting cholesterol in plasma from HDL to (V)LDL in exchange for VLDL-TG, CETP aggravates atherosclerosis in hyperlipidemic APOE*3-Leiden

Die Leiden des jungen Werthers: Den unge Werthers lidelser

OpenAIRE

Wibe, Henriette Nøddebo; Mathiassen, Jonas Bundgaard; Villadsen, Line Møgelvang; Aeppli, Jon Marius Brogaard; Hvidtfeldt, Sidi Sami Idrissi; Jakobsen, Mathias Simonsen

2013-01-01

This project investigate the philosophical influence of Jean-Jaques Rousseau’s Discours sur I’origine et les fondemens de I’inégalité parmi les hommes on Johann Wolfgang von Goethe’s Die Leiden des jungen Werthers. The concepts of the natural and conscious man that are set forth in the second Discours are compared to Werthers dualistic selfhood and the influence this has on the understanding of the narrative of Werther. Furthermore the project assesses the extent to which the revised 1787 ver...

Reversal of hypercholesterolemia in apolipoprotein E2 and apolipoprotein E3-Leiden transgenic mice by adenovirus-mediated gene transfer of the VLDL receptor

NARCIS (Netherlands)

Dijk, K.W. van; Vlijmen, B.J.M. van; Zee, A. van der; Hof, B. van 't; Boom, H. van der; Kobayashi, K.; Chan, L.; Havekes, L.M.; Hofker, M.H.

1998-01-01

We have investigated the interaction of apolipoprotein E2(Arg158- Cys) (apoE2) and apolipoprotein E3Leiden (apoE3-Leiden) with the very low density lipoprotein (VLDL) receptor in vivo and in vitro to define the possible role of this receptor in lipoprotein metabolism and atherosclerosis. The in vivo

Subacute Budd-Chiari syndrome associated with polycythemia vera and factor V Leiden mutation

NARCIS (Netherlands)

Simsek, S; Verheesen, RV; Haagsma, EB; Lourens, J

We describe a 48-year-old caucasian woman with a subacute Budd-Chiari syndrome attributed to the presence of polycythaemia vera, heterozygosity for the factor V Leiden mutation and the use of an oral contraceptive pill. Two diagnostic pitfalls were encountered. First, on CT scanning of the abdomen

Plasma hepcidin levels and anemia in old age. The Leiden 85-Plus Study

NARCIS (Netherlands)

Elzen, W.P. den; Craen, A.J. de; Wiegerinck, E.T.G.; Westendorp, R.G.J.; Swinkels, D.W.; Gussekloo, J.

2013-01-01

Hepcidin, an important regulator of iron homeostasis, is suggested to be causally related to anemia of inflammation. The aim of this study was to explore the role of plasma hepcidin in anemia among older persons from the general population. The Leiden 85-Plus Study is a population-based study of

Human Diversity : Design for life: 9th International Congress of Physiological Anthropology: Proceedings, Delft, The Netherlands, 22-26 August 2008

NARCIS (Netherlands)

Louts, T.; Reitenbach, M.E.F.R.; Molenbroek, J.F.M.

2009-01-01

This book of full papers contains the proceedings of the ICPA (International Congress of Physiological Anthropology) conference, held at the faculty of Industrial Design Engineering, TU Delft, from 22-26 August 2008.

PXR agonism decreases plasma HDL levels in ApoE*3-Leiden.CETP mice

NARCIS (Netherlands)

Haan, W. de; Vries-van der Weij, J. de; Mol, I.M.; Hoekstra, M.; Romijn, J.A.; Jukema, J.W.; Havekes, L.M.; Princen, H.M.G.; Rensen, P.C.N.

2009-01-01

Pregnane X receptor (PXR) agonism has been shown to affect multiple steps in both the synthesis and catabolism of HDL, but its integrated effect on HDL metabolism in vivo remains unclear. The aim of this study was to evaluate the net effect of PXR agonism on HDL metabolism in ApoE*3-Leiden (E3L) and

Distribution of some hydrocarbons in ambient air near Delft and the influence on the formation of secondary air pollutants

NARCIS (Netherlands)

Bos, R.; Guicherit, R.; Hoogeveen, A.

1977-01-01

The relative concentrations of hydrocarbons in the atmosphere may provide information concerning their origin. It appears that the hydrocarbon composition measured in Delft (The Netherlands) is entirely different for northern and southern wind directions. This points to different sources. The most

[R]MIT Research Centre at Delft University of Technology: A Bridge between Research, Education, Society and Profession

Science.gov (United States)

Zijlstra, Hielkje

2009-01-01

In 2006, we launched the [R]MIT Research Centre (Modification, Intervention Transformation) at the Faculty of Architecture at Delft University of Technology. [R]MIT was founded to respond to the need for an integrated, multi-disciplinary approach to the transformation of the built environment. [R]MIT aims to bring momentum to the renewal of…

Plasma and liver lipidomics response to an intervention of rimonabant in ApoE*3Leiden.CETP transgenic mice.

Directory of Open Access Journals (Sweden)

Chunxiu Hu

Full Text Available Lipids are known to play crucial roles in the development of life-style related risk factors such as obesity, dyslipoproteinemia, hypertension and diabetes. The first selective cannabinoid-1 receptor blocker rimonabant, an anorectic anti-obesity drug, was frequently used in conjunction with diet and exercise for patients with a body mass index greater than 30 kg/m(2 with associated risk factors such as type II diabetes and dyslipidaemia in the past. Less is known about the impact of this drug on the regulation of lipid metabolism in plasma and liver in the early stage of obesity.We designed a four-week parallel controlled intervention on apolipoprotein E3 Leiden cholesteryl ester transfer protein (ApoE*3Leiden.CETP transgenic mice with mild overweight and hypercholesterolemia. A liquid chromatography-linear ion trap-Fourier transform ion cyclotron resonance-mass spectrometric approach was employed to investigate plasma and liver lipid responses to the rimonabant intervention. Rimonabant was found to induce a significant body weight loss (9.4%, p<0.05 and a significant plasma total cholesterol reduction (24%, p<0.05. Six plasma and three liver lipids in ApoE*3Leiden.CETP transgenic mice were detected to most significantly respond to rimonabant treatment. Distinct lipid patterns between the mice were observed for both plasma and liver samples in rimonabant treatment vs. non-treated controls. This study successfully applied, for the first time, systems biology based lipidomics approaches to evaluate treatment effects of rimonabant in the early stage of obesity.The effects of rimonabant on lipid metabolism and body weight reduction in the early stage obesity were shown to be moderate in ApoE*3Leiden.CETP mice on high-fat diet.

History and highlights of the teratological collection in the Museum Anatomicum of Leiden University, The Netherlands

NARCIS (Netherlands)

Boer, Lucas L.; Boek, Peter L. J.; van Dam, Andries J.; Oostra, Roelof-Jan

2018-01-01

The anatomical collection of the Anatomical Museum of Leiden University Medical Center (historically referred to as Museum Anatomicum Academiae Lugduno-Batavae) houses and maintains more than 13,000 unique anatomical, pathological and zoological specimens, and include the oldest teratological

Push or Pull Students into Blended Education A Case Study at Delft University of Technology

OpenAIRE

Cervone, A.; Melkert, J.A.; Mebus, L.F.M.; Saunders, G.N.

2016-01-01

Blended education, or “flipping the classroom” is rapidly becoming a mainstream form of teaching within universities. Within Engineering Education, it is popular as it allows more time in-class to focus on hands on activities such as demonstrations and solving complex problems. This paper discusses the effort conducted to restructure, according to the blended learning principles, the “Propulsion and Power” course of the Aerospace Engineering Bachelor degree programme at Delft University of Te...

Mistaken Identity and Mirror Images: Albert and Carl Einstein, Leiden and Berlin, Relativity and Revolution

NARCIS (Netherlands)

van Dongen, J.A.E.F.

2012-01-01

Albert Einstein accepted a “special” visiting professorship at the University of Leiden in the Netherlands in February 1920. Although his appointment should have been a mere formality, it took until October of that year before Einstein could occupy his special chair. Why the delay? The explanation

On some Hymenoptera from the collection of Guerin-Méneville in the Leiden museum

NARCIS (Netherlands)

Vecht, van der J.

1957-01-01

About thirty years ago, while studying the Sphecinae of the Leiden Museum, I found two species of Sphex, described by F. E. Guérin-Méneville, represented here by specimens originating from the collection of this author. A note on these species, Sphex lanierii Guérin and Sphex paulinieri Guérin, was

In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 → Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic mice

NARCIS (Netherlands)

Vlijmen, B.J.M. van; Dijk, K.W. van; Hof, H.B. van 't; Gorp, P.J.J. van; Zee, A. van der; Boom, H. van der; Breuer, M.L.; Hofker, M.H.; Havekesf, L.M.

1996-01-01

Apolipoprotein E*2(Arg-155 → Cys) (APOE*2) transgenic mice were generated and compared to the previously generated apolipoprotein E*3- Leiden (APOE*3-Leiden) transgenic mice to study the variable expression of hyperlipoproteinemia associated with these two APOE variants. In the presence of the

Plasma lipoproteins in familial dysbetalipoproteinemia associated with apolipoproteins E2 (Arg158 -->Cys), E3-Leiden, and E2 (Lys146-->Gln), and effects of treatment with simvastatin

NARCIS (Netherlands)

Zhao, S.P.; Smelt, A.H.; Maagdenberg, A.M. van den; Tol, A. van; Vroom T.F.; Gevers Leuven, J.A.; Frants, R.R.; Havekes, L.M.; Laarse, A. van der; Hooft, F.M. van 't

1994-01-01

Using a density-gradient ultracentrifugation technique, we analyzed in detail the plasma lipoprotein profiles of 18 patients with familial dysbetalipoproteinemia (FD) who had apolipoprotein (apo) E2(Arg158-->Cys) homozygosity (the E2-158 variant, n = 6), apoE3-Leiden heterozygosity (the E3-Leiden

Ethics and engineering courses at Delft University of Technology: contents, educational setup and experiences.

Science.gov (United States)

van de Poel, I R; Zandvoort, H; Brumsen, M

2001-04-01

This article reports on the development and teaching of compulsory courses on ethics and engineering at Delft University of Technology (DUT). Attention is paid to the teaching goals, the educational setup and methods, the contents of the courses, involvement of staff from engineering schools, experiences to date, and challenges for the future. The choices made with respect to the development and teaching of the courses are placed within the European and Dutch context and are compared and contrasted with the American situation and experiences.

Technische universiteiten en duurzame ontwikkeling in Afrika : Een interfacultair studenten onderzoeksproject voor het 33e lustrumsymposium van de Technische Universiteit Delft

NARCIS (Netherlands)

Duijvestein, C.A.J.; de Vries, G.; Bos, M.; Cozijnse, K.; Findlater, J.W.; Fremouw, M.; Jonkman, J.; Oijevaar, K.; Peters, S.; van Rattinghe, K.; Sack-van Straaten, K.; De Vries, G.; Wessels, R.

2007-01-01

In 2007, Delft University of Technology celebrates its 165th birthday. This unique occasion is celebrated with several activities revolving around the subject "Sustainable Solutions, with a focus on Africa". For the interdisciplinary course "Technical Universities and Sustainable development of

The Prebiotic Inulin Aggravates Accelerated Atherosclerosis in Hypercholesterolemic APOE*3-Leiden Mice

OpenAIRE

Lisa R. Hoving; Margreet R. de Vries; Rob C. M. de Jong; Saeed Katiraei; Amanda Pronk; Paul H. A. Quax; Vanessa van Harmelen; Ko Willems van Dijk

2018-01-01

The prebiotic inulin has proven effective at lowering inflammation and plasma lipid levels. As atherosclerosis is provoked by both inflammation and hyperlipidemia, we aimed to determine the effect of inulin supplementation on atherosclerosis development in hypercholesterolemic APOE*3-Leiden (E3L) mice. Male E3L mice were fed a high-cholesterol (1%) diet, supplemented with or without 10% inulin for 5 weeks. At week 3, a non-constrictive cuff was placed around the right femoral artery to induce...

Impact of the factor V Leiden mutation on the outcome of pneumococcal pneumonia: a controlled laboratory study

NARCIS (Netherlands)

Schouten, Marcel; van 't Veer, Cornelis; Roelofs, Joris Jth; Levi, Marcel; van der Poll, Tom

2010-01-01

Introduction: Streptococcus (S.) pneumoniae is the most common cause of community-acquired pneumonia. The factor V Leiden (FVL) mutation results in resistance of activated FV to inactivation by activated protein C and thereby in a prothrombotic phenotype. Human heterozygous FVL carriers have been

Ein Werther der DDR : Plenzdorfs Neue Leiden des jungen W. im gespaltenen Deutschland

OpenAIRE

Jäger, Georg

2009-01-01

Die neuen Leiden des jungen W. wurden »bewußt auf Auslegbarkeit geschrieben« und irritierten die Kritiker durch »die ungeheure Breite der Assoziationsmöglichkeiten«. Durch die vier »strukturtragenden Schichten« oder Informationsebenen des Textes kommt es zu interferierenden Perspektiven: 1. die voranstehenden Dokumente (Zeitungsnotiz, drei Todesanzeigen), 2. »die szenisch-dialogisch objektivierte Erinnerungsperspektive der Eltern und Arbeitskollegen«, 3. die Kommentare Edgars »von jenseits de...

Cholesteryl ester transfer protein decreases high-density lipoprotein and severely aggravates atherosclerosis in APOE*3-Leiden mice

NARCIS (Netherlands)

Westerterp, M.; Hoogt, C.C. van der; Haan, W. de; Offerman, E.H.; Dallinga-Thie, G.M.; Jukema, J.W.; Havekes, L.M.; Rensen, P.C.N.

2006-01-01

OBJECTIVE - The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is still undergoing debate. Therefore, we evaluated the effect of human CETP expression on atherosclerosis in APOE*3-Leiden (E3L) mice with a humanized lipoprotein profile. METHODS AND RESULTS -

Integrated Biogeomorphological Modeling Using Delft3D

Science.gov (United States)

Ye, Q.; Jagers, B.

2011-12-01

The skill of numerical morphological models has improved significantly from the early 2D uniform, total load sediment models (with steady state or infrequent wave updates) to recent 3D hydrodynamic models with multiple suspended and bed load sediment fractions and bed stratigraphy (online coupled with waves). Although there remain many open questions within this combined field of hydro- and morphodynamics, we observe an increasing need to include biological processes in the overall dynamics. In riverine and inter-tidal environments, there is often an important influence by riparian vegetation and macrobenthos. Over the past decade more and more researchers have started to extend the simulation environment with wrapper scripts and other quick code hacks to estimate their influence on morphological development in coastal, estuarine and riverine environments. Although one can in this way quickly analyze different approaches, these research tools have generally not been designed with reuse, performance and portability in mind. We have now implemented a reusable, flexible, and efficient two-way link between the Delft3D open source framework for hydrodynamics, waves and morphology, and the water quality and ecology modules. The same link will be used for 1D, 2D and 3D modeling on networks and both structured and unstructured grids. We will describe the concepts of the overall system, and illustrate it with some first results.

Relative validity of the food frequency questionnaire used to assess dietary intake in the Leiden Longevity Study

NARCIS (Netherlands)

Streppel, M.T.; Vries, de J.H.M.; Meyboom, S.; Beekman, M.; Craen, A.J.M.; Slagboom, P.E.; Feskens, E.J.M.

2013-01-01

Background - Invalid information on dietary intake may lead to false diet-disease associations. This study was conducted to examine the relative validity of the food frequency questionnaire (FFQ) used to assess dietary intake in the Leiden Longevity Study. Methods - A total of 128 men and women

Advances in computer-aided engineering : CAD/CAM-research at Delft University of Technology. Report of the VF-project CAD/CAM 1989-1994

NARCIS (Netherlands)

Undetermined, U.

1994-01-01

This book contains a collection of articles describing on-going CAD/CAM-research at several engineering faculties at Delft University of Technology. Two main themes covered in this book are 'Conceptual design of complex products' and 'Product modelling and product data exchange'.

Charles Darwin’s lost Cinereous Harrier found in the collection of the National Museum of Natural History Leiden

NARCIS (Netherlands)

Grouw, van H.; Steinheimer, F.D.

2008-01-01

During reorganisation of the Leiden bird collection a mounted harrier was found what seemed to be one of the still lost specimens collected by Darwin. After closer research it turned out it was indeed the last missing harrier of the Darwin collection.

Institute of place making : A project by the chair of Landscape Architecture at the TU Delft. Oerol 2013: Sense of place

NARCIS (Netherlands)

Pouderoijen, M.T.; Piccinini, D.

2013-01-01

This booklet shows the results of a project developed by TU Delft in a Master elective course offered by the chair of Landscape Architecture: Landscape Architecture ON site, being part of Oerol Festival 2013. The aim of the project was to express the landscape of Terschelling into a temporarily

Has one of Captain Cook’s possums landed in Leiden? The possible holotype of Pseudocheirus peregrinus (Boddaert, 1785)

NARCIS (Netherlands)

Smeenk, C.

2009-01-01

The identity of an old female specimen of Pseudocheirus peregrinus (Boddaert, 1785) in the National Museum of Natural History, Leiden, is discussed and the early descriptions and nomenclatural history of the species are reviewed. The assumption by Temminck (1824) and Jentink (1888) that the animal

Factor V Leiden is associated with increased sperm count

DEFF Research Database (Denmark)

van Mens, T E; Joensen, U N; Bochdanovits, Z

2017-01-01

STUDY QUESTION: Is the thrombophilia mutation factor V Leiden (FVL) associated with an increased total sperm count? SUMMARY ANSWER: Carriers of FVL have a higher total sperm count than non-FVL-carriers, which could not be explained by genetic linkage or by observations in a FVL-mouse model. WHAT...... IS KNOWN ALREADY: FVL has a high prevalence in Caucasians despite detrimental health effects. Carriers have been shown to have higher fecundity, which might partly explain this evolutionary paradox. STUDY DESIGN, SIZE, DURATION: We determined FVL status in two cohorts (Dutch, n = 627; Danish, n = 854....... There were differences in smoking, abstinence time and age between the cohorts. We corrected for these in the primary analysis, which consisted of a mixed linear effects model, also incorporating unobjectified population differences. In public haplotype data from subjects of European descent, we explored...

The original Pathologische Anatomie Leiden-Endothelium monoclonal antibody recognizes a vascular endothelial growth factor binding site within neuropilin-1

NARCIS (Netherlands)

Jaalouk, Diana E.; Ozawa, Nfichael G.; Sun, Jessica; Lahdenranta, Johanna; Schlingemann, Reinier O.; Pasqualini, Renata; Arap, Wadih

2007-01-01

For two decades, the antigen recognized by the Pathologische Anatomie Leiden-Endothelium (PAL-E) monoclonal antibody, a standard vascular endothelial cell marker, has remained elusive. Here, we used a combinatorial phage display-based approach ("epitope mapping") to select peptides binding to the

Effects of dietary fish oil on serum lipids and VLDL kinetics in hyperlipidemic apolipoprotein E*3-Leiden transgenic mice

NARCIS (Netherlands)

Vlijmen, B.J.M. van; Mensink, R.P.; Hof, H.B. van 't; Offermans, R.F.G.; Hofker, M.H.; Havekes, L.M.

1998-01-01

Studying the effects of dietary fish oil on VLDL metabolism in humans is subject to both large intra- and interindividual variability. In the present study we therefore used hyperlipidentic apolipoprotein (APO) E*3-Leiden mice, which have impaired chylomicron and very low density lipoprotein (VDL)

Risk of venous thromboembolism and myocardial infarction associated with factor V Leiden and prothrombin mutations and blood type

DEFF Research Database (Denmark)

Sode, Birgitte F; Allin, Kristine H; Dahl, Morten

2013-01-01

ABO blood type locus has been reported to be an important genetic determinant of venous and arterial thrombosis in genome-wide association studies. We tested the hypothesis that ABO blood type alone and in combination with mutations in factor V Leiden R506Q and prothrombin G20210A is associated...

Computational Modeling on Concrete, Masonry and Fiber-reinforced Composites : Proceedings of the Workshop on 17 – 18 June 2009, Delft, The Netherlands

NARCIS (Netherlands)

Hendriks, M.A.N.; Billington, S.L.

2009-01-01

This booklet comprises the extended abstracts to be presented at the Ma(gni)FiCo workshop held in Delft, The Netherlands, on 17-18 June 2009. The spirit of this workshop is to have a small gathering with ample time for lively conversation and interaction among the student and faculty researchers. As

Macht, machinaties en musea. Jan van der Hoeven, Hermann Schlegel en hun strijd om het Rijksmuseum van natuurlijke historie te Leiden

Directory of Open Access Journals (Sweden)

H.L. de Jonge

2005-01-01

Full Text Available Might, machinations and museums. Jan van der Hoeven, Hermann Schlegel and their battle over the National Museum for Natural History in LeidenMuseums had a central place in nineteenth-century natural history. Aside from being important places for carrying out research into nature, they were also powerful vehicles for transmitting and communicating scientific knowledge. That is why, in the nineteenth century, natural history museums were frequently battlegrounds for rival scientists. Often, clashes over scientific matters were at the same time conflicts about power and space. After all, the naturalist who could get control over a museum’s collection and decide how the specimens should be classified and exhibited ultimately had the power to dictate which scientific knowledge was communicated; which story was told by a collection of specimens. This article is about the power struggle over the directorate of the National Museum of Natural History in Leiden that broke out between Jan van der Hoeven, Professor of Natural History and Comparative Anatomy at Leiden and Herman Schlegel, the museum’s chief curator. Both were rooted in very different natural historical traditions and had completely different views on the role of the museum and how the collection should be arranged and exhibited. In this article, we follow the two scientists in their attempts to gain support for their nominations. In this way, we also get a picture of nineteenth century Dutch political culture and the role scientists could play in it.

Phenotypic presentation of thrombophilia in double heterozygote for factor v leiden and prothrombin 20210 G>A mutations: Case report

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Nagorni-Obradović Ljudmila

2014-01-01

Full Text Available Physicians usually do not suspect pulmonary thromboembolism in younger patients except in those who have thrombophilia. In those latter patients some special conditions such as trauma or surgery may provoke the disease. In some adult persons, thrombophilia may still remain unrecognized, until appearance of additional conditions influence development of thrombosis. A 55-year-old Caucasian female, non-smoker, experienced sudden chest pain and hemoptysis without chest trauma. History taking revealed type 2 diabetes mellitus and hypothyroidism. She was overweight with body mass index 29.0. The review of the family history revealed that her father and mother died of brain infarction, while her 22-year-old son and 24-year-old daughter were healthy. Due to suspicion for thrombosis, multi-slice computerized tomography thorax scan was done and pulmonary embolism was diagnosed. Although without clear risk factor for thrombosis in our patient, we performed laboratory investigation for congenital thrombophilia. Genetic analysis showed double heterozygous for factor V Leiden and prothrombin 20210 G>A mutations. Congenital thrombophilia was risk factor for thrombosis in our patient but haemostatic imbalance was not previously clinically recognized. She had two pregnancies without complications. Appearance of other associative factors such as endocrine disorders - hypothyroidism and metabolic syndrome with diabetes type 2, and overweigh were additional potential triggers for clinical manifestation of pulmonary thromboembolism in her adult age. Her children underwent genetic analysis, too. The son was also double heterozygous for factor V Leiden and prothrombin 20210 G>A mutations, while daughter was heterozygous for factor V Leiden, and none had clinical signs of thrombosis. [Projekat Ministarstva nauke Republike Srbije, br. ON175081 i br. ON 175091

An early 'handwritten' shell exchange catalogue of the Leiden Museum, with notes on the collectors Rethaan Macaré and Tischbein

NARCIS (Netherlands)

Bruggen, van A.C.

2013-01-01

A ‘handwritten’ (lithographed) shell exchange catalogue of the National Museum of Natural History, Leiden (The Netherlands), dated 1850 and containing 864 nominal taxa (861 molluscs and 3 brachiopods), is discussed in the context of the history of the museum. This catalogue must have been

Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci.

Science.gov (United States)

Westrick, Randal J; Tomberg, Kärt; Siebert, Amy E; Zhu, Guojing; Winn, Mary E; Dobies, Sarah L; Manning, Sara L; Brake, Marisa A; Cleuren, Audrey C; Hobbs, Linzi M; Mishack, Lena M; Johnston, Alexander J; Kotnik, Emilee; Siemieniak, David R; Xu, Jishu; Li, Jun Z; Saunders, Thomas L; Ginsburg, David

2017-09-05

Factor V Leiden ( F5 L ) is a common genetic risk factor for venous thromboembolism in humans. We conducted a sensitized N -ethyl- N -nitrosourea (ENU) mutagenesis screen for dominant thrombosuppressor genes based on perinatal lethal thrombosis in mice homozygous for F5 L ( F5 L/L ) and haploinsufficient for tissue factor pathway inhibitor ( Tfpi +/- ). F8 deficiency enhanced the survival of F5 L/L Tfpi +/- mice, demonstrating that F5 L/L Tfpi +/- lethality is genetically suppressible. ENU-mutagenized F5 L/L males and F5 L/+ Tfpi +/- females were crossed to generate 6,729 progeny, with 98 F5 L/L Tfpi +/- offspring surviving until weaning. Sixteen lines, referred to as "modifier of Factor 5 Leiden ( MF5L1-16 )," exhibited transmission of a putative thrombosuppressor to subsequent generations. Linkage analysis in MF5L6 identified a chromosome 3 locus containing the tissue factor gene ( F3 ). Although no ENU-induced F3 mutation was identified, haploinsufficiency for F3 ( F3 +/- ) suppressed F5 L/L Tfpi +/- lethality. Whole-exome sequencing in MF5L12 identified an Actr2 gene point mutation (p.R258G) as the sole candidate. Inheritance of this variant is associated with suppression of F5 L/L Tfpi +/- lethality ( P = 1.7 × 10 -6 ), suggesting that Actr2 p.R258G is thrombosuppressive. CRISPR/Cas9 experiments to generate an independent Actr2 knockin/knockout demonstrated that Actr2 haploinsufficiency is lethal, supporting a hypomorphic or gain-of-function mechanism of action for Actr2 p.R258G Our findings identify F8 and the Tfpi/F3 axis as key regulators in determining thrombosis balance in the setting of F5 L and also suggest a role for Actr2 in this process.

Gas concentration and temperature in acoustically excited Delft turbulent jet flames

Energy Technology Data Exchange (ETDEWEB)

Ana Maura A. Rocha; Joao A. Carvalho Jr.; Pedro T. Lacava [Sao Paulo State University, Guaratingueta (Brazil)

2008-11-15

This paper shows the experimental results for changes in the flame structure when acoustic fields are applied in natural gas Delft turbulent diffusion flames. The acoustic field (pulsating combustion) generates zones of intense mixture of reactants in the flame region, promoting a more complete combustion and, consequently, lower pollutant emissions, increase in convective heat transfer rates, and lower fuel consumption. The results show that the presence of the acoustic field changes drastically the flame structure, mainly in the burner natural frequencies. However, for higher acoustic amplitudes, or acoustic pressures, a hydrogen pilot flame is necessary in order to keep the main flame anchored. In the flame regions where the acoustic field is more intense, premixed flame characteristics were observed. Besides, the pulsating regime modifies the axial and radial combustion structure, which could be verified by the radial distribution of concentrations of O{sub 2}, CO, CO{sub 2}, and NOx, and by the temperature profile. The experiments also presented the reduction of flame length with the increase of acoustic amplitude. 30 refs., 15 figs., 3 tabs.

Enhancement by factor V Leiden mutation of risk of deep-vein thrombosis associated with oral contraceptives containing a third-generation progestagen

NARCIS (Netherlands)

Bloemenkamp, K. W.; Rosendaal, F. R.; Helmerhorst, F. M.; Büller, H. R.; Vandenbroucke, J. P.

1995-01-01

Recent concern about the safety of combined oral contraceptives (OCs) with third-generation progestagens prompted an examination of data from a population-based case-control study (Leiden Thrombophilia Study). We compared the risk of deep-vein thrombosis (DVT) during use of the newest OCs,

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2007-03-26

Mar 26, 2007 ... Plasticity is a crucial component of the life cycle of invertebrates that live as active ... in terms of resources, or mainly in a dry season that is more stressful. ... Leiden University, PO Box 9516, 2300 RA Leiden, The Netherlands ...

Prothrombin 20210 G: a mutation and Factor V Leiden mutation in women with a history of severe preeclampsia and (H)ELLP syndrome

NARCIS (Netherlands)

van Pampus, M. G.; Wolf, H.; Koopman, M. M.; van den Ende, A.; Buller, H. R.; Reitsma, P. H.

2001-01-01

The 20210 G-A prothrombin gene variant and the Factor V Leiden mutation are mutations associated with venous thrombotic risk. The aim of our study was to assess the prevalence of these specific mutations in women with a history of preeclampsia or hemolysis elevated liver enzymes, and low platelet

Die Leiden des jungen Werthers à luz da história do conceito de subjetividade

OpenAIRE

Silva, Felipe Vale da

2013-01-01

O artigo analisa os paralelos entre o retrato do 'sujeito moderno em crise' visto no romance Die Leiden des jungen Werthers de Goethe e, por outro lado, o perfil psicossocial do 'homem do sentimento' do século XVIII, fruto da cultura da Empfindsamkeit. Defendo a perspectiva de que, no romance, Goethe não apenas se utiliza do formato literário mais tradicional da Empfindsamkeit (o do romance epistolar), como também se apropria de topói e técnicas discursivas que lhe são próprias em registro ra...

HELLP Syndrome and Cerebral Venous Sinus Thrombosis Associated with Factor V Leiden Mutation during Pregnancy

Directory of Open Access Journals (Sweden)

Zeynep Ozcan Dag

2014-01-01

Full Text Available Preeclampsia is a leading cause of maternal mortality and morbidity worldwide. The neurological complications of preeclampsia and eclampsia are responsible for a major proportion of the morbidity and mortality for women and their infants alike. Hormonal changes during pregnancy and the puerperium carry an increased risk of venous thromboembolism including cerebral venous sinus thrombosis (CVST. Factor 5 leiden (FVL is a procoagulant mutation associated primarily with venous thrombosis and pregnancy complications. We report a patient with FVL mutation who presented with CVST at 24th week of pregnancy and was diagnosed as HELLP syndrome at 34th week of pregnancy.

Contributions of radiochemistry and nuclear analytical techniques to society and technology: some examples of 35 years’ experience in Delft

International Nuclear Information System (INIS)

Bode, Peter

2013-01-01

Budget cuts and the oscillating public debates on the benefits of nuclear research reactor facilities are a continuous threat to many nuclear institutions. University affiliated institutions often face additional problems if their facilities offer sufficient scientific challenge and if an education in nuclear sciences provide students a sound outlook for a professional career. Such discussions may be an excuse for non-fulfilment of vacancies and reduced priority in the academic curriculum. Universities tend to reallocate their funds to more contemporary sciences such as molecular biology and nanotechnology. Their choices are based on relevance, quality viability and productivity. Relevance is often measured on the basis of external funding of research programs as well as on career opportunities for students. However, the areas with opportunities for external funding are largely determined by socio-economic developments, sometimes even at the (inter)national political level. The thematic areas in the scientific Framework Programs of the European Union illustrate this. The relevance and viability of an expensive facility like a nuclear reactor centre can also be demonstrated by making the facilities available to provide measurements on request by outsiders. Ideally, such services should be sustainable, but even the existence may lead to consider the centre being of regional or national importance. Nuclear reactor centres have various options for such services, like production of radionuclides; neutron transmutation doping; neutron activation analysis; neutron radiography and others. This contribution gives examples of the typical analytical services provided by the Interuniversity Reactor Institute of the Delft University of Technology. This institute houses the only university research reactor in the Netherlands, a 2 MW swimming pool reactor, with associated facilities for neutron research, neutron activation and radiochemistry. Within the services provided by the

Teaching nanoscience across scientific and geographical borders - A European Master programme in nanoscience and nanotechnology

International Nuclear Information System (INIS)

Chesneau, A; Schwille, P; Groeseneken, G; Heremans, P; Rep, D; Rudquist, P; Wendin, G; Sluijter, B

2008-01-01

Within the Erasmus Mundus Master (EMM) Programme, five European Universities (KU Leuven, Belgium, Chalmers University of Technology, Sweden, Delft University of Technology and Leiden University, the Netherlands, and the University of Dresden, Germany) have joined forces to offer a unique master programme in Nanoscience and Nanotechnology, 'EMM-nano', at the cutting edge of state-of-the-art research. The students design and build their individual area of specialisation within nanophysics, nanotechnology, biophysics, biotechnology through their choice of trajectory between the partners. We discuss some of the challenges related to the crossdisciplinary nature of the field, educational activities in cleanrooms, and issues related to the integration of teaching programmes across the borders within Europe

List of the primary types of social wasps (Hymenoptera: Vespidae) deposited in the Nationaal Natuurhistorisch Museum, Leiden, and the Zoölogisch Museum, Amsterdam

NARCIS (Netherlands)

Kojima, J.; Achterberg, van C.

1997-01-01

The primary types of social wasp subfamilies Vespinae, Polistinae and Stenogastrinae housed in the Nationaal Natuurhistorisch Museum in Leiden and the Zoölogisch Museum in Amsterdam are listed. Their complete label data are given unless they are available elsewhere. Lectotypes of Polistes snelleni

Jewish Medical Students and Graduates at the Universities of Padua and Leiden: 1617–1740

Directory of Open Access Journals (Sweden)

Kenneth Collins

2013-01-01

Full Text Available The first Jewish medical graduates at the University of Padua qualified in the fifteenth century. Indeed, Padua was the only medical school in Europe for most of the medieval period where Jewish students could study freely. Though Jewish students came to Padua from many parts of Europe the main geographical sources of its Jewish students were the Venetian lands. However, the virtual Padua monopoly on Jewish medical education came to an end during the seventeenth century as the reputation of the Dutch medical school in Leiden grew. For aspiring medieval Jewish physicians Padua was, for around three hundred years, the first, simplest, and usually the only choice.

The Leiden/Argentine/Bonn (LAB) Survey of Galactic HI : Final data release of the combined LDS and IAR surveys with improved stray-radiation corrections

NARCIS (Netherlands)

Kaberla, P.M.W.; Burton, W.B.; Hartmann, L.; Arnal, E.M.; Bajaja, E.; Morras, R.; Pöppel, W.G.L.

2005-01-01

We present the final data release of observations of ?21-cm emission from Galactic neutral hydrogen over the entire sky, merging the Leiden/Dwingeloo Survey (LDS: Hartmann & Burton 1997, Atlas of Galactic Neutral Hydrogen) of the sky north of ? = ?30? with the Instituto Argentino de Radioastronomía

What We Have Learned from San Francisco Declaration on Research Assessment and Leiden Manifesto?

Directory of Open Access Journals (Sweden)

Carey Ming-Li Chen

2017-03-01

Full Text Available In recent years, the research performance evaluation of members of the academic community conducted by government or institutions has been applied with multiple indicators and peer review, however, there are many controversies about the design and application of research evaluation indicators. This article aims to introduce the development process of San Francisco Declaration on Research Assessment (DORA and Leiden Manifesto and summarize their contents of guidelines and attempts to compare the differences between these two documents. It hopes that this article can arise the attention and reflection of research evaluation indicators and relevant issues from Taiwan academic community to reach consensus of utilization of research evaluation indicators. It will be beneficial to develop the version of declaration with local characteristics in the future.

Teaching Engineering Ethics to PhD Students : A Berkeley–Delft Initiative: Commentary on “Ethics Across the Curriculum: Prospects for Broader (and Deeper) Teaching and Learning in Research and Engineering Ethics”

NARCIS (Netherlands)

Taebi, B.; Kastenberg, William E.

2016-01-01

A joint effort by the University of California at Berkeley and Delft University of Technology to develop a graduate engineering ethics course for PhD students encountered two types of challenges: academic and institutional. Academically, long-term collaborative research efforts between

Cryptic marine biota of the Raja Ampat island group : Preliminary results of the Raja Ampat Expedition , Ekspedisi Widya Nusantara (E-Win) of the Indonesian Institute of Sciences (LIPI)

NARCIS (Netherlands)

Hoeksema, B.W.; Meij, van der S.E.T.

2008-01-01

The Raja Ampat expedition in 2007 was organized by the National Museum of Natural History Naturalis in Leiden in cooperation with the Research Centre for Oceanography (RCO-LIPI, Jakarta) as part of Ekspedisi Widya Nusantara (E-Win expedition) of the Indonesian Institute of Sciences (LIPI). The

Arachidonic acid/docosahexaenoic acid-supplemented diet in early life reduces body weight gain, plasma lipids, and adiposity in later life in ApoE*3 Leiden mice

NARCIS (Netherlands)

Wielinga, P.Y.; Harthoorn, L.F.; Verschuren, L.; Schoemaker, M.H.; Jouni, Z.E.; Tol, E.A.F. van; Kleemann, R.; Kooistra, T.

2012-01-01

Scope: This study addresses whether early life arachidonic acid (ARA)/docosahexaenoic acid (DHA) supplementation or eicosapentaenoic acid (EPA)/DHA (Omacor) supplementation affects body weight gain, lipid metabolism, and adipose tissue quantity and quality in later life in ApoE*3Leiden-transgenic

Anécdotas castellanas en escritura hebraica. Apuntes paremiológicos conservados en las anotaciones hebreas de Alfonso de Zamora (Ms. Leiden Or. 645

Directory of Open Access Journals (Sweden)

Alonso Fontela, Carlos

2011-12-01

Full Text Available Problems of translation and interpretation are addressed in this presentation of Alfonso de Zamora’s Hebrew and Hebrew “Aljamiado” Spanish notes (ca. 1530 from Leiden University Library Ms. Or. 645 (ol. Warner 65 containing anecdotes, sayings and short tales. Additional notes dealing with a manuscript copy of the Targum to the Prophets comissioned by the University of Salamanca are also discussed.

Este artículo estudia algunas notas manuscritas de Alfonso de Zamora en hebreo y en aljamía hebraico-castellana datadas hacia 1530, y procedentes del ms. Or. 645 (ol. Warner 65 de la Biblioteca de la Universidad de Leiden. Dichas notas contienen anécdotas, refranes y «cuentecillos», tales como las anécdotas «de fray Palomo», «de un portugués», y «de lo que dijo el gallego». Otras anotaciones de Zamora tratan de un trabajo de copia del Targum a los Profetas por encargo de la Universidad de Salamanca.

Essay review: Een eeuw op zijn kop

Directory of Open Access Journals (Sweden)

Ad Maas

2015-02-01

Full Text Available Beschouwing naar aanleiding van de publicatie van (1 Andreas Weber, Hybrid ambitions. Science, governance, and empire (Leiden: Leiden University Press 2012. xi+263 pp., ISBN: 978-90-8728-1663, € 49,95; (2 Martin P.M. Weiss, The masses and the muses. A history of Teylers Museum in the nineteenth century (Dissertatie: Universiteit Leiden 2013. ix+332 pp.; (3 Hieke Huistra, Preparations on the move. The Leiden anatomical collections in the nineteenth century (Dissertatie: Universiteit Leiden 2013. ix+163 pp.; (4 P.A.J. Caljé, Student, universiteit en samenleving. De Groningse universiteit in de negentiende eeuw (Hilversum: Verloren 2009. 631 pp., ISBN: 978-90-6550-978-9, € 49,-.

Factor V Leiden mutation, prothrombin gene mutation, and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis: results of a case-control study

NARCIS (Netherlands)

Janssen, H. L.; Meinardi, J. R.; Vleggaar, F. P.; van Uum, S. H.; Haagsma, E. B.; van der Meer, F. J.; van Hattum, J.; Chamuleau, R. A.; Adang, R. P.; Vandenbroucke, J. P.; van Hoek, B.; Rosendaal, F. R.

2000-01-01

In a collaborative multicenter case-control study, we investigated the effect of factor V Leiden mutation, prothrombin gene mutation, and inherited deficiencies of protein C, protein S, and antithrombin on the risk of Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT). We compared 43 BCS

Factor V Leiden mutation, prothrombin gene mutation, and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis : results of a case-control study

NARCIS (Netherlands)

Janssen, HLA; Meinardi, [No Value; Vleggaar, FP; van Uum, SHM; Haagsma, EB; van der Meer, FJM; van Hattum, J; Chamuleau, RAFM; Adang, RP; Vandenbroucke, JP; van Hoek, B; Rosendaal, FR

2000-01-01

In a collaborative multicenter case-control study, we investigated the effect of factor V Leiden mutation, prothrombin gene mutation, and inherited deficiencies of protein C, protein S, and antithrombin on the risk of Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT), We compared 43 BCS

Report on the International Workshop “The Golden Horde in a Global Perspective: Imperial Strategies”, Leiden University, May 7–8, 2015 »

Directory of Open Access Journals (Sweden)

Roman Hautala

2015-09-01

Full Text Available This article contains a report on the international conference organized by the University of Leiden in May 2015. According to its organizers, this conference has become the first Western European symposium dedicated to the study of the long history of the Golden Horde. The conference became a fruitful meeting place of the leading Russian and Tatar historians and archaeologists with their Western colleagues from the Netherlands, United Kingdom, United States of America, Hungary, Poland, and Finland. International participants of the Leiden conference discussed the most topical issues of historiography associated with eventful history of the Golden Horde. In particular, the conference participants paid special attention to the study of the administration of the ulus of Jochi that naturally combined governmental models of the Mongol Empire of the Chingizids with local administrative elements. A separate section of the conference was devoted to the analysis of the religious policy of the Golden Horde khans, where special attention was paid to the historiographical debate on the Islamization of the ulus of Jochi. The conference participants also paid considerable attention to the consideration of the material culture of the Golden Horde known both from written sources and, above all, from the materials of archaeological findings. Also, a number of reports of the confe­rence was devoted to foreign and domestic policies of the Golden Horde rulers, at the same time reflecting the central geopolitical role of the ulus of Jochi on the Eurasian continent and the high level of civilization of the Golden Horde. The main achievement of the Leiden conference was a statement on the need of deeper study of the Golden Horde history in order to overcome a number of stereotypes regarding misconceptions of the ulus of Jochi represented as backward and parasitic State formation. The conference participants agreed in general opinion about the necessity of similar

An early (1850) 'handwritten' shell exchange catalogue of the Leiden Museum, with notes on the collectors Rethaan Macaré and Tischbein

OpenAIRE

Bruggen, van, A.C.

2013-01-01

A ‘handwritten’ (lithographed) shell exchange catalogue of the National Museum of Natural History, Leiden (The Netherlands), dated 1850 and containing 864 nominal taxa (861 molluscs and 3 brachiopods), is discussed in the context of the history of the museum. This catalogue must have been distributed in a limited edition to shell collectors interested in the exchange of specimens. Among the exchange partners of the museum were the well-known 19th century Dutch collector Lady (later Dowager) F...

China Back in the Frame. A comparative study of Canton, Whampoa and Macao harbour views in the Leiden Museum of Ethnology and in the Guangzhou Museum

NARCIS (Netherlands)

Poel, van der R.H.M.; Groenendijk, E.; Viallé, C.; Blussé, L.

2009-01-01

This article presents a brief overview of research results deriving from the investigation of a group of 18th and 19th century export oil paintings from China in the collection of the National Museum of Ethnology n Leiden. The oils were compared with a group of reverse glass paintings in the same

A genetic study of Factor V Leiden (G1691A) mutation in young ischemic strokes with large vessel disease in a South Indian population.

Science.gov (United States)

Anadure, Ravi; Christopher, Rita; Nagaraja, Dindagur; Narayanan, Coimbatore

2017-10-01

Factor V Leiden (FVL) has been, by far, the most investigated gene mutation, with 26 studies to date, on its role in arterial strokes. Overall, a meta-analysis of all these studies taken together showed that carriers of the Factor V Leiden allele were 1.33times more likely to develop arterial strokes when compared to controls. We subjected a highly select subset of young strokes, with large vessel infarcts, to genetic analysis for FVL mutation and compared them with matched healthy controls to look for a statistically significant association. In this prospective study, 6/120 cases (5%) and 2/120 controls (1.6%) were positive for heterozygous FVL (G1691A) mutation. The higher prevalence of FVL mutation in cases (5%) compared to controls (1.6%) did not show statistical significance with a Pearson's Chi square P value of 0.15. The Odds Ratio (OR) for risk of large vessel disease in FVL positive cases was 3.10 (95% CI of 0.61-15.7). FVL mutation (G1691A) in young Indian subjects with ischemic strokes does not seem to be significantly associated with large vessel disease. Copyright © 2017 Elsevier Ltd. All rights reserved.

The association of factor V G1961A (factor V Leiden), prothrombin G20210A, MTHFR C677T and PAI-1 4G/5G polymorphisms with recurrent pregnancy loss in Bosnian women.

Science.gov (United States)

Jusić, Amela; Balić, Devleta; Avdić, Aldijana; Pođanin, Maja; Balić, Adem

2018-08-01

Aim To investigate association of factor V Leiden, prothrombin G20210A, MTHFR C677T and PAI-1 4G/5G polymorphisms with recurrent pregnancy loss in Bosnian women. Methods A total of 60 women with two or more consecutive miscarriages before 20 weeks of gestation with the same partners and without history of known causes or recurrent pregnancy loss were included. A control group included 80 healthy women who had one or more successful pregnancies without history of any complication which could be associated with miscarriages. Genotyping of factor V Leiden, prothrombin G20210A, MTHFR C677T and PAI-1 4G/5G polymorphisms were performed by polymerase chain reaction/restriction fragments length polymorphism method (PCR/RFLP). Results Both factor V Leiden and MTHFR C677T polymorphisms were significantly associated with recurrent pregnancy loss (RPL) in Bosnian women while prothrombin G20210A and PAI-1 4G/5G polymorphisms did not show strongly significant association. Conclusion The presence of thrombophilic polymorphisms may predispose women to recurrent pregnancy loss. Future investigation should be addressed in order to find when carriers of those mutations, polymorphisms should be treated with anticoagulant therapy. Copyright© by the Medical Assotiation of Zenica-Doboj Canton.

Cerebral infarction and femoral venous thrombosis detected in a patient with diabetic ketoacidosis and heterozygous factor V Leiden G1691A and PAI-1 4G/5G mutations.

Science.gov (United States)

Yaroglu Kazanci, Selcen; Yesilbas, Osman; Ersoy, Melike; Kihtir, Hasan Serdar; Yildirim, Hamdi Murat; Sevketoglu, Esra

2015-09-01

Cerebral infarction is one of the serious neurological complications of diabetic ketoacidosis (DKA). Especially in patients who are genetically prone to thrombosis, cerebral infarction may develop due to inflammation, dehydration, and hyperviscocity secondary to DKA. A 6-year-old child with DKA is diagnosed with cerebral infarction after respiratory insufficiency, convulsion, and altered level of consciousness. Femoral and external iliac venous thrombosis also developed in a few hours after central femoral catheter had been inserted. Heterozygous type of factor V Leiden and PAI-14G/5G mutation were detected. In patients with DKA, cerebral infarction may be suspected other than cerebral edema when altered level of consciousness, convulsion, and respiratory insufficiency develop and once cerebral infarction occurs the patients should also be evaluated for factor V Leiden and PAI-14G/5G mutation analysis in addition to the other prothrombotic risk factors.

Thrombophilic Genetic Factors PAI-1, MTHFRC677T, V Leiden 506Q, and Prothrombin 20210A in Noncirrhotic Portal Vein Thrombosis and Budd-Chiari Syndrome in a Caucasian Population

Directory of Open Access Journals (Sweden)

Mario D’Amico

2013-01-01

Full Text Available Thrombophilic genetic factors PAI-1, MTHFRC677T, V Leiden 506Q, and Prothrombin 20210A were studied as risk factors in 235 Caucasian subjects: 85 patients with abdominal thrombosis (54 with portal vein thrombosis (PVT and 31 with Budd-Chiari syndrome (BCS without liver cirrhosis or hepatocellular carcinoma and 150 blood bank donors. Seventy-five patients with PVT/BCS showed associated disease or particular clinical status (46 PVT/29 BCS: 37 myeloproliferative neoplasm (20 PVT/17 BCS, 12 abdominal surgery (10 PVT/2 BCS, 10 contraception or pregnancy (6 PVT/4 BCS, 7 abdominal acute disease (6 PVT/1 BCS, and 9 chronic disease (4 PVT/5 BCS; ten patients did not present any association (8 PVT/2 BCS. PAI-14G-4G, MTHFR677TT, and V Leiden 506Q were significantly frequent (OR 95% CI and χ2 test with P value in abdominal thrombosis; in these patients PAI-14G-4G and MTHFR677TT distributions deviated from that expected from a population in the Hardy-Weinberg equilibrium (PAI-1: χ2=13.8, P<0.001; MTHFR677: χ2=7.1, P<0.01, whereas the equilibrium was respected in healthy controls. V Leiden Q506 and Prothrombin 20210A were in the Hardy-Weinberg equilibrium both in patients with abdominal thrombosis and healthy controls. Our study shows an important role of PAI-14G-4G and MTHFR677TT in abdominal thrombosis without liver cirrhosis or hepatocellular carcinoma.

New Frontiers in Analyzing Dynamic Group Interactions: Bridging Social and Computer Science.

Science.gov (United States)

Lehmann-Willenbrock, Nale; Hung, Hayley; Keyton, Joann

2017-10-01

This special issue on advancing interdisciplinary collaboration between computer scientists and social scientists documents the joint results of the international Lorentz workshop, "Interdisciplinary Insights into Group and Team Dynamics," which took place in Leiden, The Netherlands, July 2016. An equal number of scholars from social and computer science participated in the workshop and contributed to the papers included in this special issue. In this introduction, we first identify interaction dynamics as the core of group and team models and review how scholars in social and computer science have typically approached behavioral interactions in groups and teams. Next, we identify key challenges for interdisciplinary collaboration between social and computer scientists, and we provide an overview of the different articles in this special issue aimed at addressing these challenges.

Filtration Characterization Method as Tool to Assess Membrane Bioreactor Sludge Filterability—The Delft Experience

Directory of Open Access Journals (Sweden)

Maria Lousada-Ferreira

2014-04-01

Full Text Available Prevention and removal of fouling is often the most energy intensive process in Membrane Bioreactors (MBRs, responsible for 40% to 50% of the total specific energy consumed in submerged MBRs. In the past decade, methods were developed to quantify and qualify fouling, aiming to support optimization in MBR operation. Therefore, there is a need for an evaluation of the lessons learned and how to proceed. In this article, five different methods for measuring MBR activated sludge filterability and critical flux are described, commented and evaluated. Both parameters characterize the fouling potential in full-scale MBRs. The article focuses on the Delft Filtration Characterization method (DFCm as a convenient tool to characterize sludge properties, namely on data processing, accuracy, reproducibility, reliability, and applicability, defining the boundaries of the DFCm. Significant progress was made concerning fouling measurements in particular by using straight forward approaches focusing on the applicability of the obtained results. Nevertheless, a fouling measurement method is still to be defined which is capable of being unequivocal, concerning the fouling parameters definitions; practical and simple, in terms of set-up and operation; broad and useful, in terms of obtained results. A step forward would be the standardization of the aforementioned method to assess the sludge filtration quality.

Die Leiden des jungen Werthers à luz da história do conceito de subjetividade

Directory of Open Access Journals (Sweden)

Felipe Vale da Silva

2013-06-01

Full Text Available O artigo analisa os paralelos entre o retrato do 'sujeito moderno em crise' visto no romance Die Leiden des jungen Werthers de Goethe e, por outro lado, o perfil psicossocial do 'homem do sentimento' do século XVIII, fruto da cultura da Empfindsamkeit. Defendo a perspectiva de que, no romance, Goethe não apenas se utiliza do formato literário mais tradicional da Empfindsamkeit (o do romance epistolar, como também se apropria de topói e técnicas discursivas que lhe são próprias em registro radicalmente heterodoxo. A argumentação nos ligará a uma dedução da visão do conceito de subjetividade moderna com que Goethe trabalha em sua fase final do Sturm und Drang, e que o situa como importante nome do discurso filosófico da modernidade.

Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study

DEFF Research Database (Denmark)

van der Spoel, Evie; Rozing, Maarten P; Houwing-Duistermaat, Jeanine J

2015-01-01

Reduced insulin/insulin-like growth factor 1 (IGF-1) signaling has been associated with longevity in various model organisms. However, the role of insulin/IGF-1 signaling in human survival remains controversial. The aim of this study was to test whether circulating IGF-1 axis parameters associate...... with old age survival and functional status in nonagenarians from the Leiden Longevity Study. This study examined 858 Dutch nonagenarian (males≥89 years; females≥91 years) siblings from 409 families, without selection on health or demographic characteristics. Nonagenarians were divided over sex...

University rankings in computer science

DEFF Research Database (Denmark)

Ehret, Philip; Zuccala, Alesia Ann; Gipp, Bela

2017-01-01

This is a research-in-progress paper concerning two types of institutional rankings, the Leiden and QS World ranking, and their relationship to a list of universities’ ‘geo-based’ impact scores, and Computing Research and Education Conference (CORE) participation scores in the field of computer...... science. A ‘geo-based’ impact measure examines the geographical distribution of incoming citations to a particular university’s journal articles for a specific period of time. It takes into account both the number of citations and the geographical variability in these citations. The CORE participation...... score is calculated on the basis of the number of weighted proceedings papers that a university has contributed to either an A*, A, B, or C conference as ranked by the Computing Research and Education Association of Australasia. In addition to calculating the correlations between the distinct university...

The Prebiotic Inulin Aggravates Accelerated Atherosclerosis in Hypercholesterolemic APOE*3-Leiden Mice.

Science.gov (United States)

Hoving, Lisa R; de Vries, Margreet R; de Jong, Rob C M; Katiraei, Saeed; Pronk, Amanda; Quax, Paul H A; van Harmelen, Vanessa; Willems van Dijk, Ko

2018-02-03

The prebiotic inulin has proven effective at lowering inflammation and plasma lipid levels. As atherosclerosis is provoked by both inflammation and hyperlipidemia, we aimed to determine the effect of inulin supplementation on atherosclerosis development in hypercholesterolemic APOE*3-Leiden ( E3L ) mice. Male E3L mice were fed a high-cholesterol (1%) diet, supplemented with or without 10% inulin for 5 weeks. At week 3, a non-constrictive cuff was placed around the right femoral artery to induce accelerated atherosclerosis. At week 5, vascular pathology was determined by lesion thickness, vascular remodeling, and lesion composition. Throughout the study, plasma lipids were measured and in week 5, blood monocyte subtypes were determined using flow cytometry analysis. In contrast to our hypothesis, inulin exacerbated atherosclerosis development, characterized by increased lesion formation and outward vascular remodeling. The lesions showed increased number of macrophages, smooth muscle cells, and collagen content. No effects on blood monocyte composition were found. Inulin significantly increased plasma total cholesterol levels and total cholesterol exposure. In conclusion, inulin aggravated accelerated atherosclerosis development in hypercholesterolemic E3L mice, accompanied by adverse lesion composition and outward remodeling. This process was not accompanied by differences in blood monocyte composition, suggesting that the aggravated atherosclerosis development was driven by increased plasma cholesterol.

The Prebiotic Inulin Aggravates Accelerated Atherosclerosis in Hypercholesterolemic APOE*3-Leiden Mice

Directory of Open Access Journals (Sweden)

Lisa R. Hoving

2018-02-01

Full Text Available The prebiotic inulin has proven effective at lowering inflammation and plasma lipid levels. As atherosclerosis is provoked by both inflammation and hyperlipidemia, we aimed to determine the effect of inulin supplementation on atherosclerosis development in hypercholesterolemic APOE*3-Leiden (E3L mice. Male E3L mice were fed a high-cholesterol (1% diet, supplemented with or without 10% inulin for 5 weeks. At week 3, a non-constrictive cuff was placed around the right femoral artery to induce accelerated atherosclerosis. At week 5, vascular pathology was determined by lesion thickness, vascular remodeling, and lesion composition. Throughout the study, plasma lipids were measured and in week 5, blood monocyte subtypes were determined using flow cytometry analysis. In contrast to our hypothesis, inulin exacerbated atherosclerosis development, characterized by increased lesion formation and outward vascular remodeling. The lesions showed increased number of macrophages, smooth muscle cells, and collagen content. No effects on blood monocyte composition were found. Inulin significantly increased plasma total cholesterol levels and total cholesterol exposure. In conclusion, inulin aggravated accelerated atherosclerosis development in hypercholesterolemic E3L mice, accompanied by adverse lesion composition and outward remodeling. This process was not accompanied by differences in blood monocyte composition, suggesting that the aggravated atherosclerosis development was driven by increased plasma cholesterol.

Science and Service at a University Research Reactor

International Nuclear Information System (INIS)

Bode, Peter

2013-01-01

Experiences of the Laboratory for Instrumental Neutron Activation Analysis (INAA) of the Reactor Institute Delft at the Delft University of Technology are presented on basis of more than 30 years experience with INAA services to others. Recommendations are given to neutron activation analysis groups starting as a service provider, but also pitfalls are identified. The importance of fitness for intended purpose is emphasized, so that analysis protocols should be optimized to answer the customer’s basic question, rather than to yield the highest number of elements and best level of precision. The absence of automation and no return of revenues are identified as highest threats of becoming a successful and reliable partner for providing services. (author)

Influence of Factor V Leiden on susceptibility to and outcome from critical illness: a genetic association study

DEFF Research Database (Denmark)

Benfield, Thomas; Ejrnæs, Karen; Juul, Klaus

2010-01-01

ABSTRACT: INTRODUCTION: Disturbance of the pro-coagulatant and anti-coagulant balance is associated with a poor outcome from critical illness. The objective of this study is to determine whether the Factor V Leiden (FVL) mutation is associated with susceptibility to or death from critical illness....... METHODS: A genetic association study involving four case cohorts comprising two Gram negative sepsis, one invasive pneumococcal disease and one intensive care unit cohort with a total of 1,249 patients. Controls were derived from a population-based cohort study (N = 8,147). DNA from patients and controls...... not appear to increase the risk of admission due to severe invasive infections. Nevertheless, in the subgroup of patients admitted to intensive care an increased risk and a poorer long-term outcome for individuals with critical illness were observed for FVL mutation carriers....

Exploring the use of automated vehicles as last mile connection of train trips through an agent-based simulation model: An application to Delft, Netherlands

Directory of Open Access Journals (Sweden)

Arthur Scheltes

2017-06-01

Full Text Available The last mile in a public transport trip is known to bring a large disutility for passengers, because the conventional transport modes for this stage of the trip can, in many cases, be rather slow, inflexible and not provide a seamless experience to passengers. Fully automated vehicles (AVs, that is, those which do not need a driver, could act as a first mile/last mile connection to mass public transport modes. In this paper, we study a system that we call Automated Last-Mile Transport (ALMT, which consists of a fleet of small, fully automated, electric vehicles to improve the last mile performance of a trip done in a train. An agent-based simulation model was proposed for the ALMT whereby a dispatching algorithm distributes travel requests amongst the available vehicles using a FIFO sequence and selects a vehicle based on a set of specified control conditions (e.g. travel time to reach a requesting passenger. The model was applied to the case-study of the connection between the train station Delft Zuid and the Technological Innovation Campus (Delft, The Netherlands in order to test the methodology and understand the performance of the system in function of several operational parameters and demand scenarios. The most important conclusion from the baseline scenario was that the ALMT system was only able to compete with the walking mode and that additional measures were needed to increase the performance of the ALMT system in order to be competitive with cycling. Relocating empty vehicles or allowing pre-booking of vehicles led to a significant reduction in average waiting time, whilst allowing passengers to drive at a higher speed led to a large reduction in average travel time, whilst simultaneously reducing system capacity as energy use is increased.

Blood group AB and factor V Leiden as risk factors for pre-eclampsia: a population-based nested case-control study.

Science.gov (United States)

Hiltunen, Leena M; Laivuori, Hannele; Rautanen, Anna; Kaaja, Risto; Kere, Juha; Krusius, Tom; Paunio, Mikko; Rasi, Vesa

2009-06-01

Pre-eclampsia is an important cause of maternal morbidity and mortality. Its etiology is still unknown. Clinical symptoms correlate with activation of coagulation and inherited thrombophilia has been associated with pre-eclampsia. ABO blood group has been associated with thrombotic disorders and pre-eclampsia. We assessed ABO blood group, seven thrombophilia associated polymorphisms, and anti-beta2-glycoprotein I antibodies as risk factors for pre-eclampsia. We performed a population-based nested case-control study of 100,000 consecutive pregnancies in Finland. Cases and controls were identified by combining national registers and medical records were reviewed. We studied 248 cases fulfilling strict criteria for pre-eclampsia and 679 controls. Severe pre-eclampsia, early pre-eclampsia, and pre-eclampsia with intra-uterine growth restriction (IUGR) were analyzed separately. Blood group AB increased the risk for pre-eclampsia as a whole (OR 2.1, 95% CI 1.3-3.5), and in the three subgroups (OR 2.3, 3.8, 3.4; 95% CI 1.3-3.9, 2.0-7.1, 1.6-7.1). FV Leiden increased the risk as a whole (OR 1.7, 95% CI 0.8-3.9), and in the three subgroups, although not statistically significantly. Anti-beta2-glycoprotein I antibodies were not associated with pre-eclampsia. High body mass index, diabetes, first pregnancy, and twin pregnancy increased the risk from 1.5-fold to 8.2-fold. Our results confirm and extend the prior observation of blood group AB being a risk factor for pre-eclampsia. ABO blood group is known from all pregnant women. The value of blood group as risk factor for pre-eclampsia should be further assessed in prospective studies. In this study, FV Leiden was not statistically significant risk factor.

Green micro-resistojet research at Delft University of Technology: new options for Cubesat propulsion

Science.gov (United States)

Cervone, A.; Zandbergen, B.; Guerrieri, D. C.; De Athayde Costa e Silva, M.; Krusharev, I.; van Zeijl, H.

2017-03-01

The aerospace industry is recently expressing a growing interest in green, safe and non-toxic propellants for the propulsion systems of the new generation of space vehicles, which is especially true in the case of Cubesat micro-propulsion systems. Demanding requirements are associated to the future missions and challenges offered by this class of spacecraft, where the availability of a propulsion system might open new possibilities for a wide range of applications including orbital maintenance and transfer, formation flying and attitude control. To accomplish these requirements, Delft University of Technology is currently developing two different concepts of water-propelled micro-thrusters based on MEMS technologies: a free molecular micro-resistojet operating with sublimating solid water (ice) at low plenum gas pressure of less than 600 Pa, and a more conventional micro-resistojet operating with liquid water heated and vaporized by means of a custom designed silicon heating chamber. In this status review paper, the current design and future expected developments of the two micro-propulsion concepts is presented and discussed, together with an initial analysis of the expected performance and potential operational issues. Results of numerical simulations conducted to optimize the design of the heating and expansion slots, as well as a detailed description of the manufacturing steps for the conventional micro-resistojet concept, are presented. Some intended steps for future research activities, including options for thrust intensity and direction control, are briefly introduced.

Construction, jobs and affordable energy in the north of the Netherlands; Bouwen, Banen en Betaalbare energie in Noord-Nederland

Energy Technology Data Exchange (ETDEWEB)

Blom, M.; Schepers, B. [CE Delft, Delft (Netherlands); Tieben, B. [SEO Economic Research, Amsterdam (Netherlands)

2013-03-15

Additional investments to boost the energy efficiency of the housing stock in the north of the Netherlands can create a substantial number of new jobs in construction and supply industries. That is the conclusion of a pilot study carried out by CE Delft and SEO Economic Research. Depending on the energy efficiency target adopted, an annual investment of around euro 400 million would lead to some 4,500 new jobs (in the first year). This would mean over 2,000 unemployed construction workers being able to return to work. To realise these investments requires a 'quantum leap' in funding. For an efficiency improvement scenario of 2% per annum this would mean a quadrupling of present investment plans in this part of the country [Dutch] Extra investeringen in energiebesparing van bestaande woningen kunnen voor Noord-Nederland een fors aantal banen in de bouw en de toeleverende industrie op leveren. Dat is de conclusie uit een verkenning die door CE Delft en SEO Economisch Onderzoek in opdracht van de Natuur en Milieufederatie Drenthe is uitgevoerd. Afhankelijk van de besparingsdoelstelling leiden investeringen van zo'n 400 miljoen per jaar tot zo'n 4.500 extra banen (eerste jaar). Daarmee kunnen ruim 2.000 werkloze bouwvakkers aan het werk worden geholpen. Om deze investeringen te kunnen realiseren, is een forse schaalsprong nodig in het financieringsaanbod. In het scenario van 2%+ per jaar komt dit neer op een verviervoudiging van de huidige investeringsambitie in Noord-Nederland.

Wer sich den Göttern widersetzt, der stirbt jung : Untersuchung der Unvermeidbarkeit des Suizids in Die Leiden des jungen Werthers hinsichtlich der Strömung des „Sturm und Drang“

OpenAIRE

Andersson, Rasmus

2015-01-01

Der Ausgang des Romans Die Leiden des Jungen Werther (1774, von Johann Wolfgang von Goethe) wird beim ersten Anblick oft als tragische Folge einer unglücklichen und unerwiderten Liebe zu Lotte angesehen. In dieser vorliegenden Arbeit wird der weit erforschten Frage der Unvermeidbarkeit des Suizids im Werk eine alternative Deutung geliefert. Diese ist außerhalb des Romans angesiedelt, und zeigt, dass der Suizid schon in der Epoche angelegt ist.

Masters in Nuclear Security

International Nuclear Information System (INIS)

Rickwood, Peter

2013-01-01

Continuing global efforts to improve the security of nuclear and other radioactive material against the threat of malicious acts are being assisted by a new initiative, the development of a corps of professional experts to strengthen nuclear security. The IAEA, the European Commission, universities, research institutions and other bodies working in collaboration have established an International Nuclear Security Education Network (INSEN). In 2011, six European academic institutions, the Vienna University of Technology, the Brandenburg University of Applied Sciences, the Demokritos National Centre for Scientific Research in Greece, the Reactor Institute Delft of the Delft University of Technology in the Netherlands, the University of Oslo, and the University of Manchester Dalton Nuclear Institute, started developing a European Master of Science Programme in Nuclear Security Management. In March 2013, the masters project was inaugurated when ten students commenced studies at the Brandenburg University of Applied Sciences in Germany for two weeks. In April, they moved to the Delft University of Technology in the Netherlands for a further two weeks of studies. The pilot programme consists of six teaching sessions in different academic institutions. At the inauguration in Delft, IAEA Director General Yukiya Amano commended this effort to train a new generation of experts who can help to improve global nuclear security. ''It is clear that we will need a new generation of policy-makers and nuclear professionals - people like you - who will have a proper understanding of the importance of nuclear security,'' Mr. Amano told students and faculty members. ''The IAEA's goal is to support the development of such programmes on a global basis,'' said David Lambert, Senior Training Officer in the IAEA's Office of Nuclear Security. ''An existing postgraduate degree programme focused on nuclear security at Naif Arab University for Security Sciences (NAUSS) is currently supported by

Thromboembolic events in Fabry disease and the impact of factor V Leiden.

Science.gov (United States)

Lenders, Malte; Karabul, Nesrin; Duning, Thomas; Schmitz, Boris; Schelleckes, Michael; Mesters, Rolf; Hense, Hans-Werner; Beck, Michael; Brand, Stefan-Martin; Brand, Eva

2015-03-10

Although several reports suggest an increased thromboembolic event rate, especially regarding strokes and TIAs at early age in patients with Fabry disease (FD), the risk for patients with FD to experience these events, the clinical relevance of additional risk factors including the concurrence of factor V Leiden (FVL), and the benefit of enzyme replacement therapy (ERT) regarding these events remain unclear. Three hundred four consecutively recruited patients with FD were evaluated for their lifetime occurrence of thromboembolic events such as stroke, TIA, deep vein thrombosis, and pulmonary embolism. The thromboembolic risk was determined in patients with FD and concurrent FVL, and the impact of ERT was assessed. The 304 patients with FD had a median age of 41 years and 53 (17.4%) had experienced at least one thromboembolic event during their lifetime. Among 226 patients with FD screened for FVL, 16 gene carriers were identified (7.1%). The occurrence of thromboembolic events in patients with FD and concurrent FVL was significantly increased compared to those without FVL (hazard ratio = 5.45, 95% confidence interval 2.29-12.99; p risk of thromboembolic events compared to those without ERT (hazard ratio = 0.362, 95% confidence interval 0.132-0.992; p = 0.0422). This observational study confirms that patients with FD have a high risk of clinically relevant thromboembolic events, which could be aggravated by a concurrence of FVL. ERT might be of benefit in preventing vascular events in patients with FD. The latter observation needs confirmation, however, by randomized and controlled clinical trials. © 2015 American Academy of Neurology.

A quick scan of economic value of offshore wind versus biomass co-combustion; Quick scan economische waarde van wind op zee versus biomassabijstook

Energy Technology Data Exchange (ETDEWEB)

Rooijers, F.J.; Bennink, D.; Blom, M.J.

2013-05-15

Co-combustion of biomass in conventional power stations is currently cheaper than offshore wind power. By the year 2025, though, both forms of renewable energy are expected to be similarly priced. Because offshore wind yields more added value for the Dutch economy and employment than biomass cocombustion, it would seem more logical to earmark more of the funds under the SDE (Dutch renewable energy subsidy scheme) for the former. At the request of the Netherlands Society for Nature and Environment (Natuur en Milieu) CE Delft compared the two generating options to assess how the Netherlands can boost use of renewable energy in the economically wisest manner in the years ahead. This issue is also to be discussed in upcoming consultations under the umbrella of the Netherlands Social and Economic Council (SER), where a new national energy agreement is to be hammered out [Dutch] Biomassabijstook is op dit moment goedkoper dan wind op zee. De verwachting is echter dat tegen 2025 de prijs van beide vormen van hernieuwbare energie vergelijkbaar kunnen zijn. Doordat de toegevoegde waarde voor de Nederlandse economie en werkgelegenheid van wind op zee groter is dan van biomassabijstook, lijkt het logischer dat uit de SDE-gelden meer wind op zee dan biomassa bijstook wordt betaald. Voor Natuur en Milieu heeft CE Delft een vergelijking gemaakt tussen deze twee technieken om de vraag te beantwoorden op welke economisch verstandige manier Nederland de komende jaren het gebruik van hernieuwbare energie kan realiseren. Die vraag is ook aan de orde in het SER-overleg dat de komende maand moet leiden tot een Energieakkoord.

Hydraulic Structures : Caissons

NARCIS (Netherlands)

Voorendt, M.Z.; Molenaar, W.F.; Bezuyen, K.G.

These lecture notes on caissons are part of the study material belonging to the course 'Hydraulic Structures 1' (code CTB3355), part of the Bachelor of Science education and the Hydraulic Engineering track of the Master of Science education for civil engineering students at Delft University of

The relationship of the factor V Leiden mutation or the deletion-deletion polymorphism of the angiotensin converting enzyme to postoperative thromboembolic events following total joint arthroplasty

Directory of Open Access Journals (Sweden)

Fang Carrie

2001-04-01

Full Text Available Abstract Background Although all patients undergoing total joint arthroplasty are subjected to similar risk factors that predispose to thromboembolism, only a subset of patients develop this complication. The objective of this study was to determine whether a specific genetic profile is associated with a higher risk of developing a postoperative thromboembolic complication. Specifically, we examined if the Factor V Leiden (FVL mutation or the deletion polymorphism of the angiotensin-converting enzyme (ACE gene increased a patient's risk for postoperative thromboembolic events. The FVL mutation has been associated with an increased risk of idiopathic thromboembolism and the deletion polymorphism of the ACE gene has been associated with increased vascular tone, attenuated fibrinolysis and increased platelet aggregation. Methods The presence of these genetic profiles was determined for 38 patients who had a postoperative symptomatic pulmonary embolus or proximal deep venous thrombosis and 241 control patients without thrombosis using molecular biological techniques. Results The Factor V Leiden mutation was present in none of the 38 experimental patients and in 3% or 8 of the 241 controls (p = 0.26. Similarly there was no difference detected in the distribution of polymorphisms for the ACE gene with the deletion-deletion genotype present in 36% or 13 of the 38 experimental patients and in 31% or 74 of the 241 controls (p = 0.32. Conclusions Our results suggest that neither of these potentially hypercoaguable states are associated with an increased risk of symptomatic thromboembolic events following total hip or knee arthroplasty in patients receiving pharmacological thromboprophylaxis.

Analysis and visualization of animal movement

NARCIS (Netherlands)

Shamoun-Baranes, J.; van Loon, E.E.; Purves, R.S.; Speckmann, B.; Weiskopf, D.; Camphuysen, C.J.

2012-01-01

The interdisciplinary workshop ‘Analysis and Visualization of Moving Objects’ was held at the Lorentz Centre in Leiden, The Netherlands, from 27 June to 1 July 2011. It brought together international specialists from ecology, computer science and geographical information science actively involved in

Intravenous Remifentanil Analgaesia for an Obstetric Patient with Type I Neurofibromatosis and a Factor V Leiden Mutation

Directory of Open Access Journals (Sweden)

José L. Gálvez

2018-01-01

Full Text Available Type I neurofibromatosis is characterised by altered skin pigmentation and the growth of benign tumours, particularly along the peripheral nerves and central nervous system. We report a 36-year-old primigravida woman in labour who was admitted to the obstetric suite of the Hospital Sant Joan de Déu, Barcelona, Spain, in 2007 with hypothyroidism, type I neurofibromatosis and a factor V Leiden mutation. Due to a lack of cranial and spinal imaging data, an epidural was not indicated; instead, continuous intravenous remifentanil analgaesia was administered. The remifentanil infusion was self-titrated by the patient using a visual analogue scale, with the dosage ranging from 0.01 to 0.25 μg/kg/minute. Due to rotational dystocia, Kjelland-type forceps were used during the delivery. After birth, the infant was found to have Apgar scores of 9 and 10, with no maternal or neonatal adverse effects observed. Although still controversial, remifentanil may be a successful alternative for analgaesia in similar cases; however, the specific risks and benefits for each patient should be considered prior to administration.

Factor V Leiden does not have a role in cryptogenic ischemic stroke among Iranian young adults.

Science.gov (United States)

Kheradmand, Ehsan; Pourhossein, Meraj; Amini, Gilda; Saadatnia, Mohammad

2014-01-01

Different risk factors have been suggested for ischemic stroke in young adults. In a group of these patients despite of extensive diagnostic work-up, the primary cause remains unknown. Coagulation tendency is accounted as a possible cause in these patients. Previous studies on factor V Leiden (FVL) as the main cause of inherited thrombophilia for clarifying the role of FVL in stroke have resulted in controversial findings. The current study investigates the role of this factor in ischemic stroke among Iranians. This case-control study was performed between September 2007 and December 2008 in Isfahan, Iran. The case group comprised of 22 patients of which 15 were males and 7 were females with age range of ≤50 years, diagnosed as ischemic stroke without classic risk factors and the control group consisted of 54 healthy young adults. After filling consent form, venous blood samples were obtained and sent to the laboratory for genetic examination. No FVL mutation was found in the case group. There was one carrier of the mutation as heterozygous in the control group (relative frequency = 1.85%). Based on our study, FVL might not be considered as an independent risk factor for ischemic stroke in Iranian individuals who are not suffering from other risk factors of ischemic stroke.

Factor V leiden and ischemic stroke risk: the Genetics of Early Onset Stroke (GEOS) study.

Science.gov (United States)

Hamedani, Ali G; Cole, John W; Cheng, Yuching; Sparks, Mary J; O'Connell, Jeffrey R; Stine, Oscar C; Wozniak, Marcella A; Stern, Barney J; Mitchell, Braxton D; Kittner, Steven J

2013-05-01

Factor V Leiden (FVL) has been associated with ischemic stroke in children but not in adults. Although the FVL mutation is associated with increased risk for venous thrombosis, its association with ischemic stroke in young adults remains uncertain. Therefore, we examined the association between FVL and ischemic stroke in participants of the Genetics of Early Onset Stroke (GEOS) study. A population-based case control study identified 354 women and 476 men 15 to 49 years of age with first-ever ischemic stroke and 907 controls. Participant-specific data included vascular risk factors, FVL genotype and, for cases, the ischemic stroke subtype by modified Trial of ORG 10172 in Acute Stroke criteria. Logistic regression was used to calculate odds ratios for the entire population and for subgroups stratified by risk factors and ischemic stroke subtype. The frequency of the FVL mutation was similar between ischemic stroke patients (3.6%; 95% confidence interval [CI] 2.5%-5.1%) and nonstroke controls (3.8%; 95% CI 2.7%-5.2%). This frequency did not change significantly when cases were restricted to patients with stroke of undetermined etiology (4.1%; 95% CI 2.6%-6.4%). Among young adults, we found no evidence for an association between FVL and either all ischemic stroke or the subgroup with stroke of undetermined etiology. Published by Elsevier Inc.

Coagulopathy triggered autoimmunity: experimental antiphospholipid syndrome in factor V Leiden mice

Science.gov (United States)

2013-01-01

Background We investigated interactions between genetically and autoimmune-mediated coagulopathies by inducing experimental antiphospholipid syndrome (eAPS) in mice carrying the factor V Leiden (FVL) mutation. Methods eAPS was induced in heterozygous and homozygous FVL transgenic mice (C57BL/6 background) by immunization with β2-glycoprotein I (β2-GPI). Autoantibody levels were measured at 1 and 5 months post-immunization. Mice were tested at 4 months post-immunization for behavior and cognitive function in the staircase, elevated plus-maze, and swim T-maze tests. Brains were removed and analyzed by immunohistochemistry for inflammatory markers and neurodegenerative processes. Results A single immunization with β2-GPI induced significantly higher and longer-lasting immune responses, and this was dependent on the number of FVL alleles. At 1 and 5 months post-immunization, levels of antibodies rose from 1.17 ± 0.07 to 1.62 ± 0.17 (optical density units; ODU) in homozygous FVL mice, compared with stable levels of 0.59 ± 0.17 and 0.48 ± 0.16 ODU in heterozygous FVL mice and a drop from 1.62 ± 0.21 to 0.61 ± 0.13 ODU in wild-type mice. Behavioral and cognitive clinical features of eAPS were also correlated with FVL allele load, as assessed by the elevated plus-maze (altered anxiety), staircase (hyperactivity and higher exploration), and swim T-maze (impaired learning) tests. Histological studies identified significant neurodegenerative changes in both grey and white matter in the eAPS-FVL brains. In spite of the potential interaction of two prothrombotic disease states, there were no ischemic lesions seen in this group. Conclusions The results indicate that genetically mediated coagulopathies increase the risk of developing coagulation-targeted autoimmune responses, and suggest the importance of antibody-mediated neurodegenerative processes in the brain in APS. PMID:23566870

Economics and handling perspectives, more than an energy levy. An essay on the contribution economics can provide to solving climate problems with regard to the BsIK project The Matrix

International Nuclear Information System (INIS)

De Bruyn, S. Themaleider Milieu-Economie CE Delft

2010-10-01

The Matrix is a multi-annual trans-disciplinary project of the Dutch Bsik program 'Klimaat voor ruimte' (Climate for space)that focuses on developing trading perspectives for the climate crisis in a collaboration between climate science, economy, spatial planning and social sciences. CE Delft addressed the economic component of this project. In this essay, the author sketches the interface between economic sciences and the climate issue. [nl

Storm Surge Modeling of Typhoon Haiyan at the Naval Oceanographic Office Using Delft3D

Science.gov (United States)

Gilligan, M. J.; Lovering, J. L.

2016-02-01

The Naval Oceanographic Office provides estimates of the rise in sea level along the coast due to storm surge associated with tropical cyclones, typhoons, and hurricanes. Storm surge modeling and prediction helps the US Navy by providing a threat assessment tool to help protect Navy assets and provide support for humanitarian assistance/disaster relief efforts. Recent advancements in our modeling capabilities include the use of the Delft3D modeling suite as part of a Naval Research Laboratory (NRL) developed Coastal Surge Inundation Prediction System (CSIPS). Model simulations were performed on Typhoon Haiyan, which made landfall in the Philippines in November 2013. Comparisons of model simulations using forecast and hindcast track data highlight the importance of accurate storm track information for storm surge predictions. Model runs using the forecast track prediction and hindcast track information give maximum storm surge elevations of 4 meters and 6.1 meters, respectively. Model results for the hindcast simulation were compared with data published by the JSCE-PICE Joint survey for locations in San Pedro Bay (SPB) and on the Eastern Samar Peninsula (ESP). In SPB, where wind-induced set-up predominates, the model run using the forecast track predicted surge within 2 meters in 38% of survey locations and within 3 meters in 59% of the locations. When the hindcast track was used, the model predicted within 2 meters in 77% of the locations and within 3 meters in 95% of the locations. The model was unable to predict the high surge reported along the ESP produced by infragravity wave-induced set-up, which is not simulated in the model. Additional modeling capabilities incorporating infragravity waves are required to predict storm surge accurately along open coasts with steep bathymetric slopes, such as those seen in island arcs.

From go-faster stripes to sliding tracksuits

NARCIS (Netherlands)

Tigges, J.

2012-01-01

Today sports and science go increasingly hand in hand. Together with private companies, sporting bodies and other research centres, TU Delft is involved in many innovative sports-related projects, particularly in water sports, where materials can be crucial.

A Joint Venture Model for Teaching Required Courses in "Ethics and Engineering" to Engineering Students

Science.gov (United States)

Zandvoort, H.; Van Hasselt, G. J.; Bonnet, J. A. B. A. F.

2008-01-01

We present our experience, spanning more than 10 years of teaching a course on "ethics and engineering" for a group of MSc programmes in applied sciences at Delft University of Technology. The course is taught by a team of teachers from the faculty of Applied Sciences and from the department of Philosophy of the Faculty of Technology,…

Marine traffic systems + Supplement

NARCIS (Netherlands)

Langeraar, W.; Glansdorp, C.C.

1976-01-01

Proceedings of an international symposium organized by Department of Naval Architecture and Maritime Studies of the Delft University of Technology, Liverpool Polytechnic, The Netherlands Maritime Institute, The Royal Institute of Navigation, The University of Wales Institute of Science and

A prepared speech in front of a pre-recorded audience: subjective, physiological, and neuroendocrine responses to the Leiden Public Speaking Task.

Science.gov (United States)

Westenberg, P Michiel; Bokhorst, Caroline L; Miers, Anne C; Sumter, Sindy R; Kallen, Victor L; van Pelt, Johannes; Blöte, Anke W

2009-10-01

This study describes a new public speaking protocol for youth. The main question asked whether a speech prepared at home and given in front of a pre-recorded audience creates a condition of social-evaluative threat. Findings showed that, on average, this task elicits a moderate stress response in a community sample of 83 12- to 15-year-old adolescents. During the speech, participants reported feeling more nervous and having higher heart rate and sweatiness of the hands than at baseline or recovery. Likewise, physiological (heart rate and skin conductance) and neuroendocrine (cortisol) activity were higher during the speech than at baseline or recovery. Additionally, an anticipation effect was observed: baseline levels were higher than recovery levels for most variables. Taking the anticipation and speech response together, a substantial cortisol response was observed for 55% of participants. The findings indicate that the Leiden Public Speaking Task might be particularly suited to investigate individual differences in sensitivity to social-evaluative situations.

The life, science and times of Lev Vasilevich Shubnikov pioneer of Soviet cryogenics

CERN Document Server

Reinders, L J

2018-01-01

This book describes the life, times and science of the Soviet physicist Lev Vasilevich Shubnikov (1901-1937).  From 1926 to 1930 Shubnikov worked in Leiden where he was the co-discoverer of the Shubnikov-De Haas effect. After his return to the Soviet Union he founded in Kharkov in Ukraine the first low-temperature laboratory in the Soviet Union, which in a very short time became the foremost physics institute in the country and among other things led to the discovery of type-II superconductivity. In August 1937 Shubnikov, together with many of his colleagues, was arrested and shot early in November 1937. This gripping story gives deep insights into the pioneering work of Soviet physicists before the Second World War, as well as providing much previously unpublished information about their brutal treatment at the hands of the Stalinist regime.

The Trouble with Opium. Taste, Reason and Experience in Late Galenic Pharmacology with Special Regard to the University of Leiden (1575-1625).

Science.gov (United States)

Klerk, Saskia

2014-01-01

In the seventeenth century, the discrepancy between the taste of some drugs and their effects on the body was used to criticize Galenic medicine. In this paper, I argue that such contradictions were brought to light by the sixteenth-century study of drug properties within the Galenic tradition itself. Investigating how the taste of a drug corresponded to the effects it had on the body became a core problem for maintaining a medical practice that was both rational and effective. I discuss four physicians, connected to the University of Leiden, who attempted to understand drug properties, including taste, within a Galenic framework. The sixteenth-century discussions about the relationship between the senses, reason and experience, will help us understand the seventeenth-century criticism of Galenic medicine and the importance of discussions about materia medica for ideas regarding the properties of matter proposed in this period.

Deep vein thrombosis, ecythyma gangrenosum and heparin-induced thrombocytopenia occurring in a man with a heterozygous Factor V Leiden mutation

Directory of Open Access Journals (Sweden)

Mariya Apostolova

2012-11-01

Full Text Available Skin necrosis and limb gangrene are occasional thrombotic manifestations of anticoagulation therapy. We report a man heterozygous for the Factor V Leiden (FVL mutation, and with a history of recurrent deep venous thrombosis, who initially presented with a necrotic skin lesion of the right flank while on warfarin therapy with a therapeutic international normalized ratio. Warfarin was discontinued and he received intravenous heparin. Thereafter he developed thrombocytopenia and pedal erythema and was diagnosed with heparin-induced thrombocytopenia (HIT. Heparin was replaced with argatroban. He ultimately underwent bilateral below-knee amputations for the thrombotic complications of the HIT. The initial necrotic lesion healed with antibiotics and wound care. Pathologic examination of multiple biopsy specimens revealed two separate lesions. One was necrotic tissue infiltrated with methicillin resistant Staphylococcus aureus having features of ecthyma gangrenosum. The second showed thrombotic changes consistent with HIT. The case illustrates the differential diagnosis of skin necrosis and limb gangrene in patients on warfarin and heparin, and also the clinical complexities that can occur in a FVL heterozygote.

African Studies Abstracts Online : number 53, 2016

NARCIS (Netherlands)

African Studies Centre Leiden (ASCL),

2016-01-01

ASA Online provides a quarterly overview of journal articles and edited works on Africa in the field of the social sciences and the humanities available in the ASC library. Issue 53 (2016). African Studies Centre, Leiden.

African Studies Abstracts Online: number 53, 2016

OpenAIRE

African Studies Centre Leiden (ASCL)

2016-01-01

ASA Online provides a quarterly overview of journal articles and edited works on Africa in the field of the social sciences and the humanities available in the ASC library. Issue 53 (2016). African Studies Centre, Leiden.

Stemcell Information: SKIP000532 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available yology, Leiden University Medical Center, Leiden, and Interuniversity Cardiology Institute of the Netherland...ty Medical Center, Leiden, and Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherl...ands Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, and Interuniversity Cardiology...University Medical Center, Leiden, and Interuniversity Cardiology Institute of th... Embryology, Leiden University Medical Center, Leiden, and Interuniversity Cardiology Institute of the Nethe

Development and Evaluation of Science and Technology Education Program Using Interferometric SAR

Science.gov (United States)

Ito, Y.; Ikemitsu, H.; Nango, K.

2016-06-01

This paper proposes a science and technology education program to teach junior high school students to measure terrain changes by using interferometric synthetic aperture radar (SAR). The objectives of the proposed program are to evaluate and use information technology by performing SAR data processing in order to measure ground deformation, and to incorporate an understanding of Earth sciences by analyzing interferometric SAR processing results. To draft the teaching guidance plan for the developed education program, this study considers both science and technology education. The education program was used in a Japanese junior high school. An educational SAR processor developed by the authors and the customized Delft object-oriented radar interferometric software package were employed. Earthquakes as diastrophism events were chosen as practical teaching materials. The selected events indicate clear ground deformation in differential interferograms with high coherence levels. The learners were able to investigate the ground deformations and disasters caused by the events. They interactively used computers and became skilled at recognizing the knowledge and techniques of information technology, and then they evaluated the technology. Based on the results of pre- and post-questionnaire surveys and self-evaluation by the learners, it was clarified that the proposed program was applicable for junior high school education, and the learners recognized the usefulness of Earth observation technology by using interferometric SAR. The usefulness of the teaching materials in the learning activities was also shown through the practical teaching experience.

New Frontiers in Analyzing Dynamic Group Interactions : Bridging Social and Computer Science

NARCIS (Netherlands)

Lehmann-Willenbrock, Nale; Hung, H.S.; Keyton, Joann

2017-01-01

This special issue on advancing interdisciplinary collaboration between computer scientists and social scientists documents the joint results of the international Lorentz workshop, “Interdisciplinary Insights into Group and Team Dynamics,” which took place in Leiden, The Netherlands, July 2016.

Educating engineering practice in six design projects in a row

NARCIS (Netherlands)

Kamp, A.

2013-01-01

Tomorrow’s engineers are required to have a good balance between deep working knowledge of engineering sciences and engineering skills. In the Bachelor in Aerospace Engineering at TU Delft, students are educated to master these competences so that they are ready to engineer when they graduate. The

Six Aerospace design projects to learn how to engineer

NARCIS (Netherlands)

Kamp, A.

2013-01-01

Tomorrow’s engineers are required to have a good balance of deep working knowledge of engineering sciences and engineering skills. In the Bachelor in Aerospace Engineering at TU Delft, students are educated to master these competences so that they are ready to engineer when they graduate. The

Journal of Astrophysics and Astronomy | Indian Academy of Sciences

Indian Academy of Sciences (India)

2016-01-27

Jan 27, 2016 ... With a mean rms optical depth of ∼ 0.003, this is the most sensitive Galactic HI 21-cm line absorption survey to date. To supplement the absorption data, we have extracted the HI 21-cm line emission profiles towards these 102 lines of sight from the Leiden Dwingeloo Survey of Galactic neutral hydrogen.

Book Review: A Bibliography of Ethiopian-Eritrean Studies in ...

African Journals Online (AJOL)

Jon Abbink, A Bibliography of Ethiopian-Eritrean Studies in Society and. History, 1995-2010. Publisher: Leiden African Studies Centre and Organisation for Social Science Research in Eastern and Southern Africa (OSSREA), 2010; 740pp. + index; ISBN: 978-99944-55-51-5 ...

Changes in steel can be heard : The knock-on effect of flipping crystal lattices

NARCIS (Netherlands)

Van Bohemen, S.; Den Ouden, G.; Van de Graaf, A.

2002-01-01

Cracks in welds are a major problem in the steel processing industry. One of the causes is a change in the microstructure that occurs if steel cools too rapidly during the welding process. Researcher Stefan van Bohemen of the Applied Sciences faculty at TU Delft demonstrates how this change is

OpenEarth : Using Google Earth as outreach for NCK's data

NARCIS (Netherlands)

de Boer, G.J.; Baart, F.; Bruens, A.; Damsma, T.; van Geer, P.; Grasmeijer, B.; den Heijer, C.; van Koningsveld, M.; Santinelli, G.

2012-01-01

In 2003 various projects at Deltares and the TU-Delft merged their toolboxes for marine and coastal science and engineering into one toolbox, culminating in 2008 in an open source release, known as OpenEarthTools (OET). OpenEarth adopts the wikipedia approach to growth: web 2.0 crowd sourcing. All

Book Reviews

Directory of Open Access Journals (Sweden)

Hans Antlöv

1996-04-01

Full Text Available - R. Anderson Sutton, Wim van Zanten, Ethnomusicology in the Netherlands: present situation and traces of the past. Leiden: Centre of Non-Western Studies, Leiden University, 1995, ix + 330 pp. [Oideion; The performing arts worldwide 2. Special Issue]., Marjolijn van Roon (eds. - T.E. Behrend, Willem Remmelink, The Chinese War and the collapse of the Javanese state, 1725-1743. Leiden: KITLV Press, 1994, 297 pp. [Verhandelingen 162]. - Erik Brandt, Eric Venbrux, A death in the Tiwi Islands; Conflict, ritual and social life in an Australian Aboriginal Community. Cambridge: Cambridge University Press, 1995, xvii + 269 pp. - Madelon Djajadiningrat-Nieuwenhuis, Tineke Hellwig, In the shadow of change; Images of women in Indonesian literature. Berkeley: University of California, Centers for South and Southeast Asia Studies, 1994, xiii + 259 pp. [Monograph 35]. - M. Estellie Smith, Peter J.M. Nas, Issues in urban development; Case studies from Indonesia. Leiden: Research School CNWS, 1995, 293 pp. [CNWS Publications 33]. - Uta Gärtner, Jan Becka, Historical dictionary of Myanmar. Metuchen, N.J.: Scarecrow Press, xxii + 328 pp. [Asian Historical Dictionaries 15]. - Beatriz van der Goes, H. Slaats, Wilhelm Middendorp over de Karo Batak, 1914-1919. Deel 1. Nijmegen: Katholieke Universiteit, Faculteit der Rechtsgeleerdheid, 1994, xvii + 313 pp. [Reeks Recht en Samenleving 11]., K. Portier (eds. - Stephen C. Headley, Janet Carsten, About the house, Lévi-Strauss and beyond. Cambridge: Cambridge University Press, 1995, xiv + 300 pp., Stephen Hugh-Jones (eds. - Stephen C. Headley, James J. Fox, Inside Austronesian houses; Perspectives on domestic designs for living. Canberra: Department of Anthropology, Research School of Pacific Studies, The Australian National University, 1993, x + 237 pp. - M. Hekker, Helmut Buchholt, Continuity, change and aspirations; Social and cultural life in Minahasa, Indonesia. Singapore: Institute of Southeast Asian Studies, 1994

Familial longevity is marked by better cognitive performance at middle age: the Leiden Longevity Study.

Directory of Open Access Journals (Sweden)

Marjon Stijntjes

Full Text Available BACKGROUND: Decline in cognitive performance is a highly prevalent health condition in elderly. We studied whether offspring of nonagenarian siblings with a familial history of longevity, perform better on cognitive tests compared to their partners as controls. This is relevant since it could provide insights into determinants underlying decline in cognitive performance. METHODS: Cross-sectional analysis within the longitudinal cohort of the Leiden Longevity Study consisting of middle-aged offspring of nonagenarian siblings together with their partners (n = 500, mean age (SD 66.3 (6.1 and 65.7 (7.2 years, respectively as controls. Memory function, attention and processing speed were tested using the 15-Picture Learning Test, Stroop test and Digit Symbol Substitution Test. Data were analyzed with regression adjusted for age, gender, years of education and additionally for diabetes mellitus, cardiovascular diseases, alcohol use, smoking, inflammatory markers and apolipoprotein E genotype. Robust standard errors were used to account for familial relationships among the offspring. RESULTS: Cognitive performance was worse at higher calendar age (p<0.001, all except Stroop test part 1. The offspring performed better compared to their partners on trial 3 (p = 0.005, the immediate (p = 0.016 and delayed (p = 0.004 recall of the 15-Picture Learning Test as well as on the interference and combined interference score of the Stroop test (p = 0.014 and p = 0.036, respectively in the fully adjusted model. The difference between offspring and partners was estimated to be more than three years according to the observed difference in calendar age. CONCLUSIONS: Offspring of nonagenarian siblings with a familial history of longevity have better cognitive performance compared to the group of their partners of comparable age. This effect is independent of age-related diseases and known possible confounders. Possible explanations might be differences in subclinical

PREFACE: The Science of Making Torque from Wind 2012

Science.gov (United States)

2014-12-01

The European Academy of Wind Energy (eawe) was pleased to announce its 4th scientific conference The Science of Making Torque from Wind. Predecessors have successfully been arranged in Delft, The Netherlands (2004), Lyngby, Denmark (2007) and Heraklion, Greece (2010). During the years the Torque Conference has established itself as Europe's leading scientific wind energy conference. The 2012 edition had been organized in the same tradition. More than 300 experts from academia and industry discussed the latest results and developments in fundamental and applied wind energy research, making this Science of Making Torque from Wind conference the largest one to that date. The seven keynote lectures provided the delegates with a unique overview on the state-of-the-art of science and technology. In over twenty sessions the participants discussed the most recent results in wind energy research. From numerical models to sophisticated experiments, from flow optimizations to structural designs, the numerous presentations covered a huge spectrum of ongoing scientific activities. The proceedings of the Torque 2012 combine the 110 papers that have passed the review process. We would like to thank all those who have been involved in organizing the conference and putting together these proceedings, including keynote speakers, session chairs and the enormous amount of reviewers involved. We are especially grateful to Gijs van Kuik for his untiring support. We also deeply appreciate the logistical support and technical services of the University of Oldenburg and the financial support of the State of Lower Saxony. At IOP we would like to thank Anete Ashton for her continuous encouraging support. We are looking forward to all future Torque Conferences, offering an excellent platform for the exchange of the latest and greatest scientific developments in the field of wind energy. Oldenburg, Germany, October 2014 Elke Seidel, Detlev Heinemann, Martin Kühn, Joachim Peinke and Stephan

Bιβλιοκρισία του: V. SYROS, Die Rezeption der aristotelischen politischen Philosophie bei Marsilius von Padua. Eine Untersuchung zur ersten Diktion des Defensor pacis [Studies in Medieval and Reformation Traditions, ed. by A. C. Gow, v. 134], Leiden, 2007

Directory of Open Access Journals (Sweden)

Στυλιανός ΛΑΜΠΑΚΗΣ

2012-01-01

Full Text Available   Βιβλιοκρισία του : V. SYROS, Die Rezeption der aristotelischen politischen Philosophie bei Marsilius von Padua. Eine Untersuchung zur ersten Diktion des Defensor pacis. [Studies in Medieval and Reformation Traditions, edited by Andrew Colin Gow, volume 134], Brill, Leiden-Boston 2007, σελ. X+364, ISSN 1573-4188

Factor V Leiden is associated with increased sperm count.

Science.gov (United States)

van Mens, T E; Joensen, U N; Bochdanovits, Z; Takizawa, A; Peter, J; Jørgensen, N; Szecsi, P B; Meijers, J C M; Weiler, H; Rajpert-De Meyts, E; Repping, S; Middeldorp, S

2017-11-01

Is the thrombophilia mutation factor V Leiden (FVL) associated with an increased total sperm count? Carriers of FVL have a higher total sperm count than non-FVL-carriers, which could not be explained by genetic linkage or by observations in a FVL-mouse model. FVL has a high prevalence in Caucasians despite detrimental health effects. Carriers have been shown to have higher fecundity, which might partly explain this evolutionary paradox. We determined FVL status in two cohorts (Dutch, n = 627; Danish, n = 854) of consecutively included men without known causes for spermatogenic failure, and performed an individual patient data meta-analysis of these two cohorts together with one previously published (Dutch, n = 908) cohort. We explored possible biological underpinnings for the relation between sperm count and FVL, by use of a FVL-mouse model and investigations of genetic linkage. Participants were male partners of subfertile couples (two Dutch cohorts) and young men from the general population (Danish cohort): FVL carrier rate was 4.0%, 4.6% and 7.3%, respectively. There were differences in smoking, abstinence time and age between the cohorts. We corrected for these in the primary analysis, which consisted of a mixed linear effects model, also incorporating unobjectified population differences. In public haplotype data from subjects of European descent, we explored linkage disequilibrium of FVL with all known single nucleotide polymorphisms in a 1.5 MB region around the F5 gene with an R2 cutoff of 0.8. We sequenced exons of four candidate genes hypothesized to be linked to FVL in a subgroup of FVL carriers with extreme sperm count values. The animal studies consisted of never mated 15-18-week-old C57BL/J6 mice heterozygous and homozygous for FVL and wild-type mice. We compared spermatogenesis parameters (normalized internal genitalia weights, epididymis sperm content and sperm motility) between FVL and wild-type mice. Human FVL carriers have a higher total sperm

The frequency of β-globin gene haplotypes, α-thalassemia and genetic polymorphisms of methylenetetrahydrofolate reductase, factor V Leiden and prothrombin genes in children with sickle cell disease in Rio de Janeiro, Brazil Frequência dos haplótipos da globina beta, da talassemia alfa e dos polimorfismos genéticos dos genes da metilenotetrahidrofolato redutase, do fator V Leiden e da protrombina em crianças com doença falciforme no Rio de Janeiro, Brasil

Directory of Open Access Journals (Sweden)

Isaac L. Silva Filho

2010-02-01

Full Text Available A freqüência dos haplótipos beta S e beta C do gene da globina e a prevalência de talassemia alfa e de mutações nos genes da metilenotetrahidrofolato redutase (MTHFR-C677T, do fator V de Leiden e da protrombina (G20210A foi estudada em crianças com doença falciforme do Rio de Janeiro. O haplótipo Bantu foi o mais freqüente (65,9%, 21,2% das crianças (18% heterozigotas e 3% homozigotas apresentam talassemia com mutação alfa 3.7kb, ao contrário da mutação alfa 4.2kb que não foi encontrada. Os alelos 677CT e 677TT da MTHFR foram observados em 20,2% e 4,8%, respectivamente. Os haplótipos Camarões, Árabe-Indiano e Senegal não foram detectados na amostra estudada, bem como mutações no gene do fator V de Leiden e da protrombina. Somente o haplótipo beta C CI foi observado. Esse é o primeiro estudo realizado em uma amostra proveniente do Programa de Triagem Neonatal para Hemoglobinopatias do estado do Rio de Janeiro. Apesar do Rio de Janeiro ser a segunda maior cidade brasileira e seus habitantes expressarem o elevado grau de miscigenação ocorrida no país, nossos resultados ainda coincidem com os registros históricos dos fluxos migratórios do gene beta S para o Brasil, bem como refletem a forte influência de indivíduos de origem africana na população do Rio de Janeiro.

Next-Generation Metrics: Responsible Metrics & Evaluation for Open Science

Energy Technology Data Exchange (ETDEWEB)

Wilsdon, J.; Bar-Ilan, J.; Peters, I.; Wouters, P.

2016-07-01

Metrics evoke a mixed reaction from the research community. A commitment to using data to inform decisions makes some enthusiastic about the prospect of granular, real-time analysis o of research and its wider impacts. Yet we only have to look at the blunt use of metrics such as journal impact factors, h-indices and grant income targets, to be reminded of the pitfalls. Some of the most precious qualities of academic culture resist simple quantification, and individual indicators often struggle to do justice to the richness and plurality of research. Too often, poorly designed evaluation criteria are “dominating minds, distorting behaviour and determining careers (Lawrence, 2007).” Metrics hold real power: they are constitutive of values, identities and livelihoods. How to exercise that power to more positive ends has been the focus of several recent and complementary initiatives, including the San Francisco Declaration on Research Assessment (DORA1), the Leiden Manifesto2 and The Metric Tide3 (a UK government review of the role of metrics in research management and assessment). Building on these initiatives, the European Commission, under its new Open Science Policy Platform4, is now looking to develop a framework for responsible metrics for research management and evaluation, which can be incorporated into the successor framework to Horizon 2020. (Author)

The emotional impact of genetic testing and aspects of counseling prior to prescription of oral contraceptives.

Science.gov (United States)

Gartner, Verena; Weber, Michael; Eichinger, Sabine

2008-11-01

Oral contraceptives increase the thrombotic risk in women with factor V Leiden. Emotional aspects of genetic testing prior to the prescription of oral contraceptives (OC), aspects of counseling and referral patterns are widely unknown. Two hundred forty-seven women with and 132 women without factor V Leiden were interviewed by questionnaire. One hundred sixty-one women (65%) with factor V Leiden and 63 (48%) with wild-type factor V responded. One hundred seventy-one women (76%) reported being emotionally disturbed by genetic testing. Eighty percent of women with factor V Leiden and 16% of women with wild-type factor V were discouraged from OC use. Three percent of women with factor V Leiden were encouraged to take OC. Forty-one percent of women with factor V Leiden used at least one hormone contraceptive method after diagnosis. Only 46 women (29%) with factor V Leiden were counseled about the relevance of the mutation in case of pregnancy. Testing for factor V Leiden has considerable emotional impact. Recommendations after testing are not consistently driven by the test result.

Avian and Herpetological Survey Results for Fairchild Air Force Base and Ancillary Properties

Science.gov (United States)

2014-10-02

declines . Certain taxa, such as reptiles and amphibians (collectively called “herpetofauna”; Gibbons et al. 2000, Stuart et al. 2004) and certain...Greene, T. Mills, Y. Leiden, S. Poppy, and C. T. Winne. 2000. The global decline of reptiles, déjà vu amphibians . BioScience. 50:653-666 Hallock, L...S. L. Rodrigues, D. L. Fishman, and R. W. Waller. 2004. Status and trends of amphibian declines and extinctions worldwide. Science 306:1783-1786

Reading, writing, drawing and making in the 18th-century instrument trade

Directory of Open Access Journals (Sweden)

Dr Florence Grant

2014-03-01

Full Text Available When George Adams assembled a large collection of philosophical instruments for King George III in the early 1760s, he drew on a variety of printed books as sources of experiments and instrument designs. Most important of these was Mathematical Elements of Natural Philosophy by the Dutch mathematician and philosopher Willem ’s Gravesande, whose own collection of instruments is now in the Museum Boerhaave in Leiden. Papers in the Science Museum archives reveal the specific practices through which Adams used books such as Mathematical Elements in the course of his business. These techniques included commonplacing, a widespread method for organising information in the early-modern period; and physically cutting and pasting fragments from engraved illustrations into new drawings, as part of the process of design. These practices connected mobile print with local networks of production. They fundamentally shaped the group of instruments Adams made for George III, and constitute a material link between two important collections of 18th-century instruments: those of ’s Gravesande in Leiden, and those of George III at the Science Museum in London.

Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study.

Science.gov (United States)

Rozing, Maarten P; Westendorp, Rudi G J; de Craen, Anton J M; Frölich, Marijke; de Goeij, Moniek C M; Heijmans, Bastiaan T; Beekman, Marian; Wijsman, Carolien A; Mooijaart, Simon P; Blauw, Gerard-Jan; Slagboom, P Eline; van Heemst, Diana

2010-03-01

To explore measures of metabolic syndrome and glucose metabolism in families with exceptional longevity. Case-control study. A university hospital in Leiden, the Netherlands. One hundred twenty-one offspring of nonagenarian siblings, who were enriched for familial factors promoting longevity, and 113 of their partners. No subject had diabetes mellitus. Prevalence of metabolic syndrome was determined according to the criteria of the Third Report of the National Cholesterol Education Program. Glucose tolerance was assessed according to a 2-hour oral glucose tolerance test. The offspring of nonagenarians siblings had a lower prevalence of metabolic syndrome (P=.03), similar body composition, lower mean fasting blood glucose levels (4.99 vs 5.16 mmol/L; P=.01), lower mean fasting insulin levels (5.81 vs 6.75 mU/L; P=.04), a higher mean homeostasis model assessment of insulin sensitivity (0.78 vs 0.65; P=.02), and a more-favorable glucose tolerance (mean area under the receiver operating characteristic curve for glucose (13.2 vs 14.3; P=.007) than their partners. No significant differences were observed between the offspring and their partners in beta-cell function (insulogenic index 13.6 vs 12.5; P=.38). Despite similar body composition, the offspring of nonagenarian siblings showed a lower prevalence of metabolic syndrome and better glucose tolerance than their partners, centralizing the role of favorable glucose metabolism in familial longevity.

A Formal Definition of VDM-SL

DEFF Research Database (Denmark)

Bruun, Hans; Damm, F.; Dawes, J.

1998-01-01

This joint report from the Danish Institute for Applied Computer Science (IFAD), the Technical Universities of Delft and Denmark and the University of Leicester contains the background and technical material used in the production of the ISO Standard that defines the specification language part...... and reviewers of the project - these changes have improved the style and technical correctness of the formal definitions used to define VDM-SL....

Thermodynamics, kinetics and process control of nitriding

DEFF Research Database (Denmark)

Mittemeijer, Eric J.; Somers, Marcel A. J.

1997-01-01

As a prerequisite for the predictability of properties obtained by a nitriding treatment of iron based workpieces, the relation between the process parameters and the composition and structure of the surface layer produced must be known. At present, even the description of thermodynamic equilibrium...... of pure Fe-N phases has not been fully achieved. It is shown that taking into account the ordering of nitrogen in the epsilon and gamma' iron nitride phases leads to an improved understanding of the Fe-N phase diagram. Although consideration of thermodynamics indicates the state the system strives for...... for process control of gaseous nitriding by monitoring the partial pressure of oxygen in the furnace using a solid state electrolyte is provided. At the time the work was carried out the authors were in the Laboratory of Materials Science, Delft University of Technology, Rotterdamseweg 137, 2628 AL Delft...

Sensitive Dual Color in vivo Bioluminescence Imaging Using a New Red Codon Optimized Firefly Luciferase and a Green Click Beetle Luciferase

Science.gov (United States)

2011-04-01

Bologna, Italy, 2 Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands, 3 Department of...and approved by the Bioethics Committee of Leiden University, The Netherlands (Animal protocol 08158). Allanimals received humane care in compliance

Lower blood pressure and apathy coincide in older persons with poorer functional ability: the Discontinuation of Antihypertensive Treatment in Elderly People (DANTE) Study Leiden.

Science.gov (United States)

Moonen, Justine E F; Bertens, Anne Suzanne; Foster-Dingley, Jessica C; Smit, Roelof A J; van der Grond, Jeroen; de Craen, Anton J M; de Ruijter, Wouter; van der Mast, Roos C

2015-01-01

To examine the association between blood pressure (BP) measures and symptoms of apathy and depression in older adults with various levels of functional ability. Cross-sectional study using baseline data from the Discontinuation of Antihypertensive Treatment in Elderly people (DANTE) Study Leiden. Primary care setting, the Netherlands. Community-dwelling individuals aged 75 and older (N = 430). Systolic BP (SBP), diastolic BP (DBP), and mean arterial pressure (MAP) were measured during home visits. Symptoms of apathy and depression were assessed using the Apathy Scale and the Geriatric Depression Scale (GDS-15), respectively. Stratified linear regression was performed in participants with better and worse functional ability according to the median of the Groningen Activity Restriction Scale. In participants with lower functional ability, each 10-mmHg lower SBP, DBP, and MAP was associated with higher Apathy Scale scores (0.63, 0.92, and 0.94 points, respectively, all P < .005) but not with GDS-15 scores. In participants with higher functional ability, BP measures were not associated with Apathy Scale or GDS-15 scores. In older participants with poorer functional ability, lower BP was associated with more symptoms of apathy but not depression. © 2015, Copyright the Authors Journal compilation © 2015, The American Geriatrics Society.

Heike Kamerlingh Onnes and the Road to Superconductivity

Science.gov (United States)

van Delft, Dirk

2011-03-01

The discovery of superconductivity on 8 April 1911 came as a big surprise. It was stumbled upon in the Leiden cryogenic laboratory of Heike Kamerlingh Onnes in a moment of serendipity. Three years before, the liquefaction of helium on the other hand had been the culmination of a long battle with nature. It was a meticulously prepared operation, ``big science'' in its first appearance. Until recently, careless notebook entries by Kamerlingh Onnes and his terrible handwriting had hindered a complete view to the road to superconductivity. Even a date of the fascinating discovery was lacking. How did the discovery fit into the Leiden research program? What about the research effort Kamerlingh Onnes had to put in to be sure he had found superconductivity rather than a short-circuit? What about superfluidity? Once the right interpretation of the notebooks is clear, the real story can be told.

Learning content and the creative cloud

NARCIS (Netherlands)

Specht, Marcus

2012-01-01

Specht, M. (2012, 18 April). Learning content and the creative cloud. Presentation given at the workshop for creative cloud CLICK workshop Faculteit Bouwkunde & Architectuur TU Delft, Delft, The Netherlands.

Las plantas vasculares de la Península Ibérica en la obra de Clusio: envíos de semillas de Sevilla a Leiden

Directory of Open Access Journals (Sweden)

Menéndez de Luarca, Luis Ramón-Laca

1997-12-01

Full Text Available Before 1575 Carolus Clusius visited Spain and Portugal, in what can be considered the first extensive botanical collection trip for the Iberian Peninsula. He published in 1576 Rariorum aliquot stirpium per Hispanias observatarum historia, mainly based on materials collected during that expedition. The content of this book was later merged with additional information to créate a more comprehensive work dealing with the whole European flora, Rariorum plantarum historiae, published in 1601. An important element in the generation of this second book was the collaboration of Simón de Tovar, from Seville, who contributed with shipments of seeds and bulbs to Clusius. Thanks to Tovar, the number of plants recorded in Rar. stirp. hispan, hist, was increased with some remarkable examples in Rar. pl. hist. It is particularly interesting to note that at that moment American plants were a great novelty and Seville was the gate for the introduction of most of them, i.e. Sprekelia formosissima (L. Herbert [• Amaryllis formosissima L.] or Psidium guajava L. A reconstruction of Clusius itinerary based on the collection localities is given in this paper. A discussion of the correspondence between both botanists, including a critical list of the plants sent to Leiden by Tovar is presented.Carolus Clusius, o sencillamente Clusio, visitó España y Portugal antes de 1575, en lo que puede considerarse la primera herborización sistemática de la Península Ibérica. En 1576 fue publicada en Amberes la obra Rariorum aliquot stirpium per Hispanias observatarum historia, basada fundamentalmente en el material colectado durante este viaje. Esta obra fue refundida posteriormente con información adicional en Rariorum plantarían historiae, publicada en 1601, que trataba de abarcar el conjunto de la flora europea. Un elemento importante en la génesis de esta segunda obra fue la colaboración del sevillano Simón de Tovar, quien contribuyó con envíos de semillas

Green chemical feedstocks. Potential in the EU and sustainability aspects. Support for the Biofeedstocks Sub-commission of the Corbey Commission; Groene chemische grondstoffen, potentieel in de EU en duurzaamheidsaspecten. Ondersteuning van de Subcommissie Biochemie van de Commissie Corbey

Energy Technology Data Exchange (ETDEWEB)

Croezen, H.; Bergsma, G.

2012-09-15

Besides applications for power generation and as a transport fuel, biomass can also be used as a chemical feedstock. If the chemical industry in Europe were to switch to 25% biofeedstocks, the sector's demand for biomass would approximate or even slightly exceed that of the transport sector. There are a number of options for biomass use in the chemical industry, with varying requirements for specific types of biomass. To a large extent, the raw biomass used by the chemical industry would be roughly equivalent to that currently used for transport biofuels, although certain routes would involve different bio resources. Compared with applications for transport fuels, use of biomass as a chemical feedstock often has greater environmental benefits, at lower cost. It would be very useful to establish sustainability criteria for the use of biomass by the chemical industry, too. Based partly on this study by CE Delft, the Commission for Sustainability Aspects of Biomass (the Corbey Commission) has drawn up an advisory document recommending introduction of sustainability criteria for use of biomass by the chemical industry [Dutch] Biomassa kan gebruikt wordt als bron voor elektriciteit en transportbrandstof maar ook als grondstof voor de chemie. Als de chemie in Europa voor 25% over zou schakelen op biomassa als grondstof dan zou de vraag vanuit deze sector naar vergelijkbaar of nog iets groter worden dan de vraag naar biomassa van de transportsector. Er zijn verschillende manieren om biomassa in te zetten in de chemie. Deze keuzes leiden tot een verschillende vraag naar soorten biomassa. Een groot deel van de grondstoffen voor biochemie komt overeen met grondstoffen voor de biotransportsector. Sommige routes vragen om andere grondstoffen. Vergeleken met biomassa in transport geeft inzet van biomassa in chemie vaak een hoger milieuvoordeel tegen lagere kosten. Het zou heel nuttig zijn om ook voor biomassa die gebruikt wordt door de chemie duurzaamheidscriteria op te

Judgments of Learning in Collaborative Learning Environments

NARCIS (Netherlands)

Helsdingen, Anne

2010-01-01

Helsdingen, A. S. (2010, March). Judgments of Learning in Collaborative Learning Environments. Poster presented at the 1st International Air Transport and Operations Symposium (ATOS 2010), Delft, The Netherlands: Delft University of Technology.

Instrumental neutron activation analysis of plant tissues and soils for biomonitoring in urban areas in Istanbul

Czech Academy of Sciences Publication Activity Database

Esen, A. N.; Kubešová, Marie; Haciyakupoglu, S.; Kučera, Jan

2016-01-01

Roč. 309, č. 1 (2016), s. 373-382 ISSN 0236-5731. [14th International Conference on Modern Trends in Activation Analysis (MTAA) / 11th International conference on Nuclear Analytical Methods in the Life Science (NAMLS). Delft, 23.08.2015-23.08.2015] R&D Projects: GA MŠk(CZ) LM2011019 Institutional support: RVO:61389005 Keywords : k(0)-INAA * biomonitor * tree leaves * tree twigs Subject RIV: CB - Analytical Chemistry, Separation Impact factor: 1.282, year: 2016

Impact of valvular heart disease on activities of daily living of nonagenarians: the Leiden 85-plus study a population based study.

Science.gov (United States)

van Bemmel, Thomas; Delgado, Victoria; Bax, Jeroen J; Gussekloo, Jacobijn; Blauw, Gerard J; Westendorp, Rudi G; Holman, Eduard R

2010-04-01

Data on the prevalence of valvular heart disease in very old individuals are scarce and based mostly on in-hospital series. In addition, the potential detrimental effect of valvular heart disease on the activities of daily living is unknown. The present study evaluated the prevalence of significant valvular heart disease and the impact of valvular heart disease on the activities of daily living in community dwelling nonagenarians. Nested within the Leiden 85-plus study, a population based follow-up study of the oldest old, a sample of 81 nonagenarians was recruited. The left ventricular (LV) dimensions, function and the presence and severity of heart valvular disease were evaluated by echocardiography. Significant valvular heart disease included any mitral or aortic stenosis severity, moderate or severe mitral regurgitation, moderate or severe aortic regurgitation and moderate or severe tricuspid regurgitation. Activities of daily living were assessed using the Groningen Activity Restriction Scale (GARS). LV cavity diameters (end-diastolic diameter 47 +/- 8 mm, end-systolic diameter 30 +/- 8 mm) and systolic LV function (LV ejection fraction 66 +/- 13%) were within normal for the majority of the participants. Significant valvular disease was present in 57 (70%) individuals, with mitral regurgitation and aortic regurgitation as the most frequent valve diseases (49% and 28% respectively). The GARS score between individuals with and without significant valvular heart disease was similar (36.2 +/- 9.2 vs. 34.4 +/- 13.2, p = 0.5). Nonagenarian, outpatient individuals have a high prevalence of significant valvular heart disease. However, no relation was observed between the presence of significant valvular heart disease and the ability to perform activities of daily living.

Plasminogen activator inhibitor-1 4G/5G polymorphism, factor V Leiden, prothrombin mutations and the risk of VTE recurrence.

Science.gov (United States)

Sundquist, Kristina; Wang, Xiao; Svensson, Peter J; Sundquist, Jan; Hedelius, Anna; Larsson Lönn, Sara; Zöller, Bengt; Memon, Ashfaque A

2015-11-25

Plasminogen-activator inhibitor (PAI)-1 is an important inhibitor of the plasminogen/plasmin system. PAI-1 levels are influenced by the 4G/5G polymorphism in the PAI-1 promoter. We investigated the relationship between the PAI-1 polymorphism and VTE recurrence, and its possible modification by factor V Leiden (FVL) and prothrombin (PTM) mutations. Patients (n=1,069) from the Malmö Thrombophilia Study were followed from discontinuation of anticoagulant treatment until diagnosis of VTE recurrence or the end of the study (maximum follow-up 9.8 years). One hundred twenty-seven patients (11.9 %) had VTE recurrence. PAI-1 was genotyped by TaqMan PCR. Cox regression analysis adjusted for age, sex and acquired risk factors of VTE showed no evidence of an association between PAI-1 genotype and risk of VTE recurrence in the study population as a whole. However, by including an interaction term in the analysis we showed that FVL but not PTM modified the effect of PAI-1 genotype: patients with the 4G allele plus FVL had a higher risk of VTE recurrence [hazard ratio (HR) =2.3, 95 % confidence interval (CI) =1.5-3.3] compared to patients with the 4G allele but no FVL (reference group) or FVL irrespective of PAI-1 genotype (HR=1.8, 95 % CI=1.3-2.5). Compared to reference group, 5G allele irrespective of FVL was associated with lower risk of VTE recurrence only when compared with 4G allele together with FVL. In conclusion, FVL has a modifying effect on PAI-1 polymorphism in relation to risk of VTE recurrence. The role of PAI-1 polymorphism as a risk factor of recurrent VTE may be FVL dependent.

Perspectieven in de robotica : Overzicht van samenwerkende disciplines

NARCIS (Netherlands)

Horne, C.; De Wolf, S.; Abd El Ghany, M.; Dumay, A.

1986-01-01

Symposium gehouden op 20 juni 1986 in het gebouw van de afdeling der Elektrotechniek, Technische Hogeschool Delft, georganiseerd door de IEEE Student Branch Delft, in samenwerking met IEEE Benelux Section NERG en KIvI

Architecture of instruction and delight : a socio-historical analysis of World Exhibitions as a didactic phenomenon (1798-1851-1970)

NARCIS (Netherlands)

Wesemael, van P.J.V.

2001-01-01

Vert. en bew. van het proefschrift Technische Universiteit Delft: Architectuur van instructie en vermaak : een maatschappij-historische analyse van de wereldtentoonstelling als didactisch verschijnsel (1798-1851-1970). - Delft : Publicatiebureau Bouwkunde, Faculteit der Bouwkunde, Technische

Electrochemical Oxidation and Detection of Sodium Urate in ...

African Journals Online (AJOL)

DR. MIKE HORSFALL

3 Delft University of Technology, 2600 GA Delft, The Netherlands. ABSTRACT: ... both sodium urate and mixture of urate and tartrate as a cumulative response, in alkaline media, the target ..... electrochemical oxygen demand (EOD) using a.

Insights into the effects of indicators on knowledge production in Astronomy

OpenAIRE

Heuritsch, Julia

2018-01-01

Nine interviews were conducted with astronomers from Leiden University, and a document analysis was performed on relevant institutional (self-) evaluation documents, annual reports, and CVs of the interviewees. The aim was to perform a qualitative study about the relationship between the research behaviour of astronomers and how their science is being evaluated. This study encompassed the funding and publication system as well as the indicators used to measure the scientific output, its quali...

Bible for boats

NARCIS (Netherlands)

Keuning, L.; Wassink, J.

2013-01-01

After nearly forty years researching yacht hulls in the Delft towing tank, boat expert Dr. Lex Keuning has decided to share his life’s work with yacht builders and researchers. The Delft Systematic Yacht Hull Series is available online.

Feasibility study of k (0)-INAA at the ITU TRIGA Mark II research reactor, Turkey

Czech Academy of Sciences Publication Activity Database

Esen, A. N.; Haciyakupoglu, S.; Erenturk, S.; Kubešová, Marie; Kučera, Jan

2016-01-01

Roč. 309, č. 1 (2016), s. 179-184 ISSN 0236-5731. [14th International Conference on Modern Trends in Activation Analysis (MTAA) / 11th International conference on Nuclear Analytical Methods in the Life Science (NAMLS). Delft, 23.08.2015-23.08.2015] R&D Projects: GA MŠk(CZ) LM2011019 Institutional support: RVO:61389005 Keywords : Kayzero for Windows * k0-INAA * neutron flux parametrs * standard reference materials Subject RIV: CB - Analytical Chemistry, Separation Impact factor: 1.282, year: 2016

Windvanger: EWICON wekt energie op zonder rotor

NARCIS (Netherlands)

Jaeger, de P.; Balendonck, J.

2008-01-01

De Elektrostatische Windenergie Convertor (Ewicon), ontwikkeld door onderzoekers uit Wageningen en Delft, kan wind direct omzetten in elektriciteit, zonder gebruik te maken van bewegende delen. Het rendement van het prototype is echter nog erg laag, zo blijkt uit tests aan de TU Delft. De

A fundamental study on materials for Li-ion batteries

NARCIS (Netherlands)

Verhoeven, V.W.J.

2001-01-01

In April 1997 the program "Decentralized Production and Storage for Large-Scale Application of Renewable Energy" of the Delft Interfaculty Research Centre (DIOC) was launched. In this program various groups from several Faculties of the Delft University of Technology studied the feasibility of large

Urbanism on Track : Application of tracking technologies in urbanism

NARCIS (Netherlands)

Van der Hoeven, F.D.; Van Schaick, J.; Van der Spek, S.C.; Smit, M.G.J.

2008-01-01

Tracking technologies such as GPS, mobile phone tracking, video and RFID monitoring are rapidly becoming part of daily life. Technological progress offers huge possibilities for studying human activity patterns in time and space in new ways. Delft University of Technology (TU Delft) held an

Johannes Müller, Exile Memories and the Dutch Revolt: The Narrated Diaspora, 1550-1750

Directory of Open Access Journals (Sweden)

C.A. (Annemieke Romein

2017-10-01

Full Text Available Johannes Müller, Exile Memories and the Dutch Revolt: The Narrated Diaspora, 1550-1750 (Dissertation Leiden University 2014; Leiden/ Boston: Brill. 2016, 254 pp., ISBN 9789004315914.

The potentials of porous concrete for ballistic protection

OpenAIRE

Weerheijm, J.; Roebroeks, G.; Krabbenborg, D.; Agar Ozbek, A.S.

2015-01-01

A special porous concrete has been developed by the Delft University in collaboration with TNO. The concrete has a static compressive strength of 45 MPa. It fragments at impact into small size debris relative to reference concrete. The porous concrete was developed at laboratory scale and tested at small scale. In collaboration with the Military Science faculty of NLDA a procedure was developed to upscale the production. Panels of 0.5m x 0.5m x 0.10m were produced at slightly lower strength t...

Impact of North Mara gold mine on the element contents in fish from the river Mara, Tanzania

Czech Academy of Sciences Publication Activity Database

Mohamed, N. K.; Ntarisa, A. V. R.; Makundi, I. N.; Kučera, Jan

2016-01-01

Roč. 309, č. 1 (2016), s. 421-427 ISSN 0236-5731. [14th International Conference on Modern Trends in Activation Analysis (MTAA) / 11th International conference on Nuclear Analytical Methods in the Life Science (NAMLS). Delft, 23.08.2015-23.08.2015] R&D Projects: GA MŠk(CZ) LM2011019; GA ČR(CZ) GBP108/12/G108 Institutional support: RVO:61389005 Keywords : gold mining * contamination * lungfish * catfisch * INAA * EDXRF Subject RIV: CB - Analytical Chemistry, Separation Impact factor: 1.282, year: 2016

Extra-Virgin Olive Oil with Natural Phenolic Content Exerts an Anti-Inflammatory Effect in Adipose Tissue and Attenuates the Severity of Atherosclerotic Lesions in Ldlr-/-.Leiden Mice.

Science.gov (United States)

Luque-Sierra, Amparo; Alvarez-Amor, Leticia; Kleemann, Robert; Martín, Franz; Varela, Lourdes M

2018-05-15

The present study investigates the effect of olive oils with different phenolic content in high-fat diets (HFDs) on hypertrophy and inflammation in adipose tissue and associated atherosclerosis, in the context of obesity. Ldlr-/-.Leiden mice were fed three different HFDs for 32 weeks and were compared with mice fed the standard low-fat diet (LFD). The different fats provided in the HFDs were lard (HFD-L), extra-virgin olive oil (EVOO; 79 mg kg -1 of phenolic compounds, HFD-EVOO), or EVOO rich in phenolic compounds (OL, 444 mg kg -1 of phenolic compounds, HFD-OL). All HFD-fed mice became obese, but only HFD-L-induced adipocyte hypertrophy. HFD-EVOO mice exhibited the greatest levels of Adiponectin in adipose tissue and presented atherosclerotic lesions similar to the LFD group, with a very low count of monocyte/macrophage compared with HFD-L and HFD-OL mice. Enrichment of the phenolic content of olive oil reduced the secretion of nitrites/nitrates in the aorta, but atherosclerosis was not attenuated in HFD-OL mice compared to other HFD mice. Consumption of olive oil with a natural content of phenolic compounds attenuates adipose tissue hypertrophy and inflammation and exerts antiatherosclerotic effects in mice. A higher phenolic content of olive oil did not provide further benefits in the prevention of atherosclerosis. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

What have they done with the MOOCs?! The impact of MOOCs on Campus Education

NARCIS (Netherlands)

Barbosa de Almeida Cabral, P.M.; van Valkenburg, W.F.; Dopper, S.M.; Ubachs, George; Konings, Lizzie

2016-01-01

In 2013 Delft University of Technology (TU Delft) started to offer Massive Open Online Courses (MOOCs) on the EdX platform. One of the main principles in the MOOC development process was to publish all educational resources under an open license (Creative Commons License) (Ouwehand, 2015). This

Delfi?n3Xt Nanosatellite Subsystems : Buying, Outsourcing or Internal Development

NARCIS (Netherlands)

Bouwmeester, J.; Hamann, R.J.

2009-01-01

This paper provides the results of a study of project management and systems engineering effectiveness regarding the allocation of work and procurement policy of a nanosatellite project. The Delfi-n3Xt nanosatellite is currently under development at Delft University of Technology (TU Delft) and will

Predictive value of a profile of routine blood measurements on mortality in older persons in the general population: the Leiden 85-plus Study.

Directory of Open Access Journals (Sweden)

Anne H van Houwelingen

Full Text Available BACKGROUND: Various questionnaires and performance tests predict mortality in older people. However, most are heterogeneous, laborious and a validated consensus index is not available yet. Since most older people are regularly monitored by laboratory tests, we compared the predictive value of a profile of seven routine laboratory measurements on mortality in older persons in the general population with other predictors of mortality; gait speed and disability in instrumental activities of daily living (IADL. METHODOLOGY/PRINCIPAL FINDINGS: Within the Leiden 85-plus Study, a prospective population-based study, we followed 562 participants aged 85 years for mortality over five years. At baseline (age 85 years high-density lipoprotein cholesterol, albumin, alanine transaminase, hemoglobin, creatinin clearance, C-reactive protein and homocysteine were measured. Participants were stratified based on their number of laboratory abnormalities (0, 1, 2-4 and 5-7. The predictive capacity was compared with gait speed (6-meter walking test and disability in IADL (Groningen Activity Restriction Scale by C-statistics. At baseline, 418 (74% 85-year old participants had at least one laboratory abnormality. All cause mortality risk increased with increasing number of laboratory abnormalities to a hazard ratio of 5.64 [95% CI 3.49-9.12] for those with 5-7 laboratory abnormalities (p<0.001 compared to those without abnormalities. The c-statistic was 0.66 [95% CI 0.59-0.69], similar to that of gait speed and disability in IADL. CONCLUSIONS/SIGNIFICANCE: In the general population of oldest old, the number of abnormalities in seven routine laboratory measurements predicts five-year mortality as accurately as gait speed and IADL disability.

Plasma assisted measurements of alkali metal concentrations in pressurized combustion processes

Energy Technology Data Exchange (ETDEWEB)

Hernberg, R.; Haeyrinen, V. [Tampere Univ. of Technology (Finland). Dept. of Physics

1996-12-01

The plasma assisted method for continuous measurement of alkali concentrations in product gas flows of pressurized energy processes will be tested and applied at the 1.6 MW PFBC/G facility at Delft University of Technology in the Netherlands. During the reporting period the alkali measuring device has been tested under pressurized conditions at VTT Energy, DMT, Foster-Wheeler Energia and ABB Carbon. Measurements in Delft will be performed during 1996 after installation of the hot gas filter. The original plan for measurements in Delft has been postponed due to schedule delays in Delft. The results are expected to give information about the influence of different process conditions on the generation of alkali vapours, the comparison of different methods for alkali measurement and the specific performance of our system. This will be the first test of the plasma assisted measurement method in a gasification process. The project belongs to the Joule II extension program under contract JOU2-CT93-0431. (author)

Why was this transfusion given? Identifying clinical indications for blood transfusion in health care data

Directory of Open Access Journals (Sweden)

van Hoeven LR

2018-03-01

Full Text Available Loan R van Hoeven,1,2 Aukje L Kreuger,3,4 Kit CB Roes,1 Peter F Kemper,2,4 Hendrik Koffijberg,5 Floris J Kranenburg,3,4,6 Jan MM Rondeel,7 Mart P Janssen1,2 1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands; 2Transfusion Technology Assessment Department, Sanquin Research, Amsterdam, the Netherlands; 3Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; 4Center for Clinical Transfusion Research, Sanquin Research, Leiden, the Netherlands; 5Department of Health Technology & Services Research, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, the Netherlands; 6Department of Intensive Care, Leiden University Medical Center, Leiden, the Netherlands; 7Department of Clinical Chemistry, Isala, Zwolle, the Netherlands Background: To enhance the utility of transfusion data for research, ideally every transfusion should be linked to a primary clinical indication. In electronic patient records, many diagnostic and procedural codes are registered, but unfortunately, it is usually not specified which one is the reason for transfusion. Therefore, a method is needed to determine the most likely indication for transfusion in an automated way.Study design and methods: An algorithm to identify the most likely transfusion indication was developed and evaluated against a gold standard based on the review of medical records for 234 cases by 2 experts. In a second step, information on misclassification was used to fine-tune the initial algorithm. The adapted algorithm predicts, out of all data available, the most likely indication for transfusion using information on medical specialism, surgical procedures, and diagnosis and procedure dates relative to the transfusion date.Results: The adapted algorithm was able to predict 74.4% of indications in the sample correctly (extrapolated to the full data set 75.5%. A kappa

Search for life - VSV symposium 2011; an account of the wonderful symposium organised by the VSV 'Leonardo da Vinci'

NARCIS (Netherlands)

Noordam, N.

2011-01-01

On March 8th, the Search for Life symposium took place in the TU Delft Auditorium. A day full of new visions on the hunt for extraterrestrial life was programmed. The TU Delft Auditorium provided the perfect playground for the 180 attendants to exchange thoughts on this topic

Communicatie-architectuur PLC’s en Unity

NARCIS (Netherlands)

J.L. Scholte

2017-01-01

Voor het afronden van de studie Technische Informatica aan de Haagse Hogeschool te Delft is het noodzakelijk om een afstudeeropdracht uit te voeren. In de loop van zeventien weken is deze opdracht uitgevoerd bij het bedrijf JB Systems te Vlaardingen en Delft door de afstudeerder Jordy Scholte. Dit

Prêt-à-Loger : Zero-energy home with maximum living quality increase

NARCIS (Netherlands)

Van den Dobbelsteen, A.A.J.F.

2015-01-01

At the Solar Decathlon Europe 2014 (SDE2014) competition (Versailles, France), the team from the Delft University of Technology (TU Delft) took a stance by not constructing a new-built house but demonstrating the energy renovation of a typical Dutch terraced house. Around a quarter of Dutch housing

Production and Testing of Kiln-cast Glass Components for an Interlocking, Dry-assembled Transparent Bridge

NARCIS (Netherlands)

Bristogianni, T.; Oikonomopoulou, F.; Veer, F.A.; Snijder, A.H.; Nijsse, R.

A pedestrian glass bridge, located at the TU Delft campus site, is being designed by the TU Delft Glass & Transparency Lab. Specifically, the arch-formed bridge consists of cast glass, dry-assembled, interlocking components. To validate the shape of the components, glass mock-ups in 1:2 scale

Beyond the photocopy machine revisited : Document delivery in a digital library environment

NARCIS (Netherlands)

Delhez, A.N.; De Leeuwe, J.; Dekker, R.

2005-01-01

Purpose – To discuss the recent strategic developments of Library at TU Delft. Design/methodology/approach – Developments at TU Delft are contrasted with the five key requirements for document delivery identified in an earlier article in 2001. Findings – That the strategy in most libraries is to

Editorial: Driving, cycling and flying : Trends in planning and operational transportation research in Europe

NARCIS (Netherlands)

Homem de Almeida Correia, G.; Lopes dos Santos, Bruno F.; Kroesen, M.

2017-01-01

In this special issue we present three papers selected from the 18th meeting of the EURO Working Group on Transportation (EWGT) which was held in July 2015 in Delft, the Netherlands, organized by Delft University of Technology. The selected contributions reflect the diversity of topics that were

Effect of Short-Crestedness on Wave Loads on Caisson

DEFF Research Database (Denmark)

Frigaard, Peter; Helm-Petersen, J.; Christensen, M.

1995-01-01

This repor concerns experiments carried out as a combined LIP-MAST-TAW PROJECT DURING May to July, 1994, in the Vinje-Basin at Delft Hydraulics......This repor concerns experiments carried out as a combined LIP-MAST-TAW PROJECT DURING May to July, 1994, in the Vinje-Basin at Delft Hydraulics...

The low-energy experiment on EXOSAT

International Nuclear Information System (INIS)

Bleeker, J.A.M.

1975-01-01

The present concept of the Low-Energy-Experiment (LEE) for EXOSAT was proposed by a collaboration of the X-ray astronomy groups at Mullard Space Science Laboratories at University College London, the Space Research Laboratory at Utrecht and the Cosmic Ray Working Group at Leiden. In the following paragraphs the major characteristics of the instrumentation and the expected scientific return will be discussed. The summary comprises both the approved baseline configuration and the proposed option of a small imaging telescope

Summer Conference on General Topology and Applications (10th) Held in Amsterdam on 15-18 August 1994

Science.gov (United States)

1994-08-18

topology. Joint work by: I. Juhisz and Z. Szentmiid6ssy. Room: KC1.37 Time: TUE 16:40-1 7:00 ABSTRACTS 89 Forcing and Normality, II LUcia R. Junqueira...Gerard A. Venema (Calvin College, Grand Rapids, MI, USA) J. Vermeer (TU Delft, Delft, the Netherlands) Paolo Vitolo (Universita della Basilicata, Potenza

C2-C5 hydrocarbon measurements in the Netherlands 1981-1991

NARCIS (Netherlands)

Roemer, M.; Builtjes, P.; Esser, P.; Guicherit, R.; Thijsse, T.

1999-01-01

Measurements of C2-C5 hydrocarbons on an hourly basis at the TNO site in Delft from 1982 to 1984 and at Moerdijk over the period 1981-1991 are presented. In combination with meteorological data (wind direction and wind speed) the Delft and Moerdijk series are evaluated to identify source categories,

Project Stratos; reaching space with a student-built rocket

NARCIS (Netherlands)

Haneveer, M.

2013-01-01

In the spring of 2009 a team of 15 TU Delft students travelled to Kiruna, Sweden with only one goal: to launch the rocket Stratos I they had been working on for 2 years to an altitude of over 12km, thereby claiming the European Amateur Rocket Altitude record. These students were part of Delft

Safety and effects of two red blood cell transfusion strategies in pediatric cardiac surgery patients: a randomized controlled trial

NARCIS (Netherlands)

de Gast-Bakker, D. H.; de Wilde, R. B. P.; Hazekamp, M. G.; Sojak, V.; Zwaginga, J. J.; Wolterbeek, R.; de Jonge, E.; Gesink-van der Veer, B. J.

2013-01-01

To investigate the safety and effects of a restrictive red blood cell (RBC) transfusion strategy in pediatric cardiac surgery patients. Randomized controlled trial. Pediatric ICU in an academic tertiary care center, Leiden University Medical Center, Leiden, The Netherlands. One hundred seven

EVOLVE

CERN Document Server

Deutz, André; Schütze, Oliver; Legrand, Pierrick; Tantar, Emilia; Tantar, Alexandru-Adrian

2017-01-01

This book comprises nine selected works on numerical and computational methods for solving multiobjective optimization, game theory, and machine learning problems. It provides extended versions of selected papers from various fields of science such as computer science, mathematics and engineering that were presented at EVOLVE 2013 held in July 2013 at Leiden University in the Netherlands. The internationally peer-reviewed papers include original work on important topics in both theory and applications, such as the role of diversity in optimization, statistical approaches to combinatorial optimization, computational game theory, and cell mapping techniques for numerical landscape exploration. Applications focus on aspects including robustness, handling multiple objectives, and complex search spaces in engineering design and computational biology.

Twintig jaar coeliakie bij kinderen in Nederland: Meer diagnosen en een veranderde verschijningsvorm [Twenty years of childhood coeliac disease in the Netherlands: More diagnoses and changed clinical picture

NARCIS (Netherlands)

George, E.K.; Mearin, M.L.; Kanhai, Sh.M.; Franken, H.C.M.; Houwen, R.H.J.; Hirasing, R.A.; Vandenbroucke, J.P.

1998-01-01

Objective. To assess the incidence of childhood coeliac disease in the Netherlands and to study the clinical features. Design. Prospective. Setting. Leiden University Medical Centre, Leiden, the Netherlands. Method. Cases of childhood coeliac disease in the Netherlands in 1993-1995 were identified

The Frequency of Factor V Leiden, Prothrombin G20210A and Methylenetetrahydrofolate Reductase C677T Mutations in Migraine Patients

Directory of Open Access Journals (Sweden)

Ruhsen Öcal

2010-12-01

Full Text Available OBJECTIVE: Migraine is an independent risk factor for ischemic stroke, but its pathophysiology is still unclear. Genetic factors that predispose patients to thrombosis have been studied in patients with migraine to highlight the pathogenesis, but the results remain controversial. In this study, the frequencies of factor V Leiden (FVL, prothrombin (Pt G20210A and methylenetetrahydrofolate reductase (MTHFR C677T mutations were investigated. METHODS: One hundred and sixty patients aged of 15 to 55 years with no history of systemic disease and who had been diagnosed as migraine according to the International Headache Society (IHS diagnostic criteria at Baskent University Hospital Neurology Outpatient Clinics were investigated for FVL, Pt G20210A and MTHFR C677T mutations from their genomic DNA, and the results were compared with those of healthy controls. RESULTS: One hundred and fifty five (96.9% of 160 migraine patients were homozygote normal, 5 (3.1% were heterozygote and none of them were homozygote mutant for FVL. The control group had 9.8% heterozygote individuals but the difference between the percentages was not statistically significant (p> 0.05. There were no homozygote mutant individuals in the Turkish population study in normal subjects like our study. Thirty nine (24.4% of 160 migraine patients were heterozygote and 8 (5% were homozygote mutant for MTHFR C677T. The control group had 37 (34.9% heterozygote and 6 (5.6% homozygote mutant individuals. The difference between the percentages was not statistically significant (p= 0.15. Three (1.9% of 160 migraine patients were heterozygote and 5 (2.9% of the control group were heterozygote mutant for Pt G20210A mutation. The control group had 37 (34.9% heterozygote and 6 (5.6% homozygote mutant individuals. The difference between the percentages was not statistically significant (p= 0.420. CONCLUSION: Our study indicates that FVL, Pt G20210A and MTHFR C677T gene mutations, which are considered

The Frequency of Factor V Leiden, Prothrombin G20210A and Methylenetetrahydrofolate Reductase C677T Mutations in Migraine Patients

Directory of Open Access Journals (Sweden)

Ruhsen Öcal

2010-12-01

Full Text Available OBJECTIVE: Migraine is an independent risk factor for ischemic stroke, but its pathophysiology is still unclear. Genetic factors that predispose patients to thrombosis have been studied in patients with migraine to highlight the pathogenesis, but the results remain controversial. In this study, the frequencies of factor V Leiden (FVL, prothrombin (Pt G20210A and methylenetetrahydrofolate reductase (MTHFR C677T mutations were investigated. METHODS: One hundred and sixty patients aged of 15 to 55 years with no history of systemic disease and who had been diagnosed as migraine according to the International Headache Society (IHS diagnostic criteria at Baskent University Hospital Neurology Outpatient Clinics were investigated for FVL, Pt G20210A and MTHFR C677T mutations from their genomic DNA, and the results were compared with those of healthy controls. RESULTS: One hundred and fifty five (96.9% of 160 migraine patients were homozygote normal, 5 (3.1% were heterozygote and none of them were homozygote mutant for FVL. The control group had 9.8% heterozygote individuals but the difference between the percentages was not statistically significant (p> 0.05. There were no homozygote mutant individuals in the Turkish population study in normal subjects like our study. Thirty nine (24.4% of 160 migraine patients were heterozygote and 8 (5% were homozygote mutant for MTHFR C677T. The control group had 37 (34.9% heterozygote and 6 (5.6% homozygote mutant individuals. The difference between the percentages was not statistically significant (p= 0.15. Three (1.9% of 160 migraine patients were heterozygote and 5 (2.9% of the control group were heterozygote mutant for Pt G20210A mutation. The control group had 37 (34.9% heterozygote and 6 (5.6% homozygote mutant individuals. The difference between the percentages was not statistically significant (p= 0.420. CONCLUSION: Our study indicates that FVL, Pt G20210A and MTHFR C677T gene mutations, which are considered

The Dutch constitution beyond 200 : Tradition and innovation in a multilevel legal order

NARCIS (Netherlands)

Franco Ferrari, Giuseppe; Passchier, Reijer; Voermans, W.J.M.

2018-01-01

This book covers the updated papers presented at a seminar in Leiden, the Netherlands in November 2016, which was organized by the Italian Public Comparative and European Law Association (DPCE) and the Department of Constitutional and Administrative Law of Leiden University in celebration of the

Prof. Dr. Hilbrand Boschma 22 April 1893 - 22 July 1976 : Obituary and bibliography

NARCIS (Netherlands)

Vervoort, W.

1977-01-01

Hilbrand Boschma, professor emeritus of systematic zoology and former director of the Rijksmuseum van Natuurlijke Historie (National Museum of Natural History), Leiden, Netherlands, passed away on 22 July, 1976, in Leiden at the age of 83. Born of peasant stock in IJsbrechtum, Wymbritseradeel, in

Use of transgenic mice in lipoprotein metabolism and atherosclerosis research

NARCIS (Netherlands)

Havekes, L.M.; Vlijmen, B.J.M. van; Jong, M.C.; Dijk, K.W. van; Hofker, M.H.

1997-01-01

In APOE*3-Leiden transgenic mice the atherosclerotic lesion size is correlated with plasma cholesterol. In these mice the plasma lipid levels are positively correlated with the relative amount of APOE 3-Leiden protein on the VLDL particle. The plasma cholesterol levels are influenced by diet, age

Computational Linguistics in the Netherlands 2004 : Selected papers from the fifteenth CLIN meeting

NARCIS (Netherlands)

Wouden, Ton van der; Poß, Michaela; Reckman, Hilke; Cremers, Crit

2005-01-01

This volume contains a selection of the papers presented at the fifteenth installment of Computational Linguistics in the Netherlands, held at Leiden University on Friday, December 17th, 2004. Organized by the computational linguists of what was at that time called the Leiden Centre for Linguistics

The Westward Movement of Chinese Export Harbour Views : Significant Paintings with a Social Function

NARCIS (Netherlands)

Poel, van der R.H.M.

2012-01-01

Article (Chapter) in proceedings of the First Rombouts Graduate Conference Globalization and Glocalization in China, at Leiden University, held in Leiden on 6 and 7 September 2011. This article offers a closer examination of Chinese export harbour views and, in doing so, reveals that waterfronts and

Ehrenfest en Einstein. Menselijke katalysator van het heldere denken

Directory of Open Access Journals (Sweden)

Marijn J. Hollestelle

2016-10-01

Full Text Available Ehrenfest and EinsteinEhrenfest and Einstein met just before Ehrenfest became professor at Leiden University. They had much in common and became best friends. Ehrenfest shed light on some problematic aspects of Einstein’s work and during the years acted as an important sparring partner for Einstein. Ehrenfest also explained difficult aspects of Einstein’s work to the physics community. He set others on the track of working on general relativity and made Leiden an international centre for these developments during the years 1912–1920. Ehrenfest made sure Einstein was appointed part-time professor at Leiden, from which Leiden physics profited. He also aided Bohr and Einstein during their notorious debates. Ehrenfest struggled with depression his whole life. The rapid developments and mathematicising of quantum physics, Hitler’s appointment as Reichs Chancellor, money and marriage problems worsened his depressions. In 1933 Ehrenfest committed suicide, and Einstein moved to the United States and away from the study on quantum physics.

[A clinical case of young, oral combined contraceptive using women, heterozygous carrier of the Factor V (Leiden) which revealed thrombosis of the left internal jugular vein and brain ischemia with cerebral infarction and ischemic stroke].

Science.gov (United States)

Kovachev, S; Ramshev, K; Ramsheva, Z; Ivanov, A; Ganovska, A

2013-01-01

Thrombophilia is associated with increased risks of venous thrombosis in women taking oral contraceptive preparations. Universal thrombophilia screening in women prior to prescribing oral contraceptive preparations is not supported by current evidence. The case is presented of a 23 year-old women with a personal history of interruption and on the same day started with oral contraceptive (0.03 microg ethynil estradiol - 0.075 microg gestodene), which due on a 18 pill/day to acute headache, increasing vomiting and speaking defects. Physical/neurologic/gynecologic examinations observed a normal status. The MRI and CT revealed thrombosis of the left internal jugular vein and brain ischemia with cerebral infarction and ischemic stroke. The acute therapy of thrombotic findings was accompanied with many tests. The thrombophilia PCR-Real time - test finds heterozygous carrier of the Factor V (Leiden). This case shows the need of large prospective studies that should be undertaken to refine the risks and establish the associations of thrombophilias with venous thrombosis among contraceptive users. The key to a prompt diagnosis is to know the risk factors. The relative value of a thrombophilia screening programme before contraceptive using needs to be established.

Frederik Kaiser (1808-1872) and the Modernisation of Dutch Astronomy

Science.gov (United States)

van der Heijden, Petra

Frederik Kaiser was the director of Leiden Observatory from 1837 until his death in 1872. Educated by his German-born uncle Johan Frederik Keyser (1766-1823), who was a proficient amateur astronomer, Kaiser proved to be a real observational talent. Despite the poor conditions in which he worked, his observations soon rivalled with the best in the world. Kaiser's contributions to astronomical practice include the foundation of a new, completely up-to-date observatory building in Leiden, and the introduction of statistics and precision measurements in daily practice at the observatory. Moreover he was the author of several bestselling books on popular astronomy. Kaiser had an extensive correspondence with colleagues all over Europe, mostly in Germany. Correpondents include Airy, Argelander, Von Auwers, Bessel, Encke, John Herschel, LeVerrier, Von Littrow, Schumacher, Otto W. Struve, as well as several geodesists and instrument makers. Preliminary research indicates that Frederik Kaiser played a crucial role in the revival of Dutch astronomy in the second half of the 19th century. This project aims at analysing and explaining Kaiser's activities in science, institutionalisation and popularisation, in the context of national and international developments in 19th-century astronomy and scientific culture.

TU Delft en online media

NARCIS (Netherlands)

Speekenbrink, R.J.H.

2013-01-01

Dit boek behandelt een visie op online media bij Nederlandse universiteiten. Daarbij beperk ik me tot die aspecten waarin online communicatie en/of online marketing een rol speelt. Dit boek behandelt niet de onderwijsgerelateerde aspecten van online media. Elektronische leeromgevingen, sociale media

The Rijksherbarium, in past and present

NARCIS (Netherlands)

Kalkman, C.

1979-01-01

As is explained in other papers in this jubilee volume (v. Steenis – Kruseman, Smit) it was not on purpose, but by coincidence that the Rijksherbarium came to Leiden. However, Leiden will have been the obvious alternative after Brussels, for Fischer as well as for Von Siebold. There Reinwardt,

Higgs production at next-to-next-to-leading order

Indian Academy of Sciences (India)

Instituut-Lorentz, University of Leiden, Leiden, The Netherlands. Abstract. We describe the calculation of inclusive Higgs boson production at hadronic colliders at next-to-next-to-leading order (NNLO) in perturbative quantum chromody- namics. We have used the technique developed in ref. [4]. Our results agree with those.

Hybrid computer simulation of the dynamics of the Hoger Onderwijs Reactor

International Nuclear Information System (INIS)

Moers, J.C.; Vries, J.W. de.

1976-01-01

A distributed parameter model for the dynamics of the Hoger Onderwijs Reactor (HOR) at Delft is presented. The neutronic and the thermodynamic part of this model have been separately implemented on the AD4-IBM1800 Hybrid Computer of the Delft University of Technology Computation Centre. A continuous Space/Discrete Time solution method has been employed. Some test results of the simulation are included

THERMOS, Space-Dependent Thermal Flux in 1-D Slab or Cylinder

International Nuclear Information System (INIS)

Honeck, Henry C.

2001-01-01

1 - Nature of physical problem solved: Computes the scalar thermal neutron spectrum as function of position in a one-dimensional slab (THERMOS-1) or cylindrical cell (THERMOS-2). Isotropic neutron scattering in the laboratory system is assumed. The slowing down source is computed from elastic scattering of the neutrons in a 1/E epithermal flux. Either a reflecting or vacuum boundary can be chosen. 2 - Method of solution: The velocity and space variables are replaced by discrete values. Scattering and collision probability matrices are computed and the neutron balance equation is solved by iterative techniques. A combination of a Gauss iteration, renormalization and extrapolation is used to accelerate convergence. 3 - Restrictions on the complexity of the problem: Maximum 30 velocity groups, 20 space points, 5 mixtures (assigned arbitrarily to the space points) composed of maximum 10 isotopes. An additional 10 isotopes can be specified for activation calculations and cross section averaging. The Library has received the 7090 version of this programme through the CETIS programmotheque. The 7040 version was written by the Universite libre de Bruxelles. ALGOL version was offered by Delft (Reactor Instituut Delft, Netherlands). A version for ICL computer was received from Central Research Institute for Physics of the Hungarian Academy of Sciences Budapest, Hungary

Potential for energy saving and renewable energy in Utrecht, Netherlands. Preliminary validation for the Utrecht municipality; Potentieel energiebesparing en duurzame energie Utrecht. Onderbouwingsnotitie voor de gemeente Utrecht

Energy Technology Data Exchange (ETDEWEB)

Benner, J.H.B.; Warringa, G.E.A.

2012-10-15

Utrecht has stated its intention to achieve CO2 neutrality of the local energy supply by 2030. Having conducted its own exploratory study into the steps that would need to be taken to achieve this aim, City Hall asked CE Delft to pass judgment on the target and how it is hoped to be achieved. While characterized by both CE Delft and interviewed scientists as very substantial, Utrecht's ambitions are also regarded as a worthy aim to pursue. City Hall's estimates of the reduction potential of the envisaged measures 28% of total projected emission cuts in 2030 via energy efficiency measures and 35% via renewable energy - are deemed realistic by CE Delft. Although the potential reduction via all options was estimated on the basis of the maximum feasible potential, there still remains a substantial policy gap. The analysis makes clear that robust policy choices are required in order to come close to achieving the stated ambitions [Dutch] De gemeente Utrecht heeft zich tot doel gesteld om in 2030 de lokale energievoorziening CO2-neutraal te hebben. Binnen de gemeente is een ambtelijke verkenning uitgevoerd naar de maatregelen om invulling te geven aan deze ambitie. Utrecht heeft CE Delft gevraagd een oordeel te geven over de ambitie en de invulling daarvan. De ambitie van Utrecht wordt zowel door CE Delft als geïnterviewde wetenschappers getypeerd als fors, maar tegelijk als een goed punt aan de horizon om naar toe te werken. De inschattingen van Utrecht rond het reductiepotentieel van de maatregelen worden door CE Delft beoordeeld als realistisch. Dit houdt in dat 28% van de totaal verwachte uitstoot in 2030 wordt gereduceerd door besparingsmaatregelen en 35% met de inzet van duurzame energie. Hoewel bij de inschatting van de mogelijke reductie voor alle opties is gerekend met het maximaal haalbare potentieel resteert er een aanzienlijk beleidsgat. De analyse maakt duidelijk dat echte beleidskeuzen nodig zijn om realisatie van de ambitie te benaderen.

Report on a collection of Crustacea Decapoda and Stomatopoda from Turkey and the Balkans

NARCIS (Netherlands)

Holthuis, L.B.

1961-01-01

Under the auspices of Leiden University and with the financial aid of various organisations and institutions, Messrs. E. Hennipman, P. Nijhoff, C. Swennen, A. S. Tulp, W. J. M. Vader, and W. J. J. O. de Wilde, most of whom are biological students of Leiden University, made a collecting trip to

Book Reviews

Directory of Open Access Journals (Sweden)

Redactie KITLV

2002-07-01

Full Text Available -Martin Baier, Han Knapen, Forests of fortune?; The environmental history of Southeast Borneo, 1600-1880. Leiden: The KITLV Press, 2001, xiv + 487 pp. [Verhandelingen 189] -Jean-Pascal Bassino, Per Ronnas ,Entrepreneurship in Vietnam; Transformations and dynamics. Copenhagen: Nordic Institute of Asian Studies (NIAS and Singapore: Institute of Southeast Asian Studies, 2001, xii + 354 pp., Bhargavi Ramamurty (eds -Adriaan Bedner, Renske Biezeveld, Between individualism and mutual help; Social security and natural resources in a Minangkabau village. Delft: Eburon, 2001, xi + 307 pp. -Linda Rae Bennett, Alison Murray, Pink fits; Sex, subcultures and discourses in the Asia-Pacific. Clayton, Victoria: Monash Asia Institute, 2001, xii + 198 pp. [Monash Papers on Southeast Asia 53.] -Peter Boomgaard, Laurence Monnais-Rousselot, Médecine et colonisation; L'aventure indochinoise 1860-1939. Paris: CNRS Editions, 1999, 489 pp. -Ian Coxhead, Yujiro Hayami ,A rice village saga; Three decades of Green revolution in the Philippines. Houndmills, Basingstoke: MacMillan, 2000, xviii + 274 pp., Masao Kikuchi (eds -Robert Cribb, Frans Hüsken ,Violence and vengeance; Discontent and conflict in New Order Indonesia. Saarbrücken: Verlag für Entwicklungspolitik, 2002, 163 pp. [Nijmegen Studies in Development and Cultural Change 37.], Huub de Jonge (eds -Frank Dhont, Michael Leifer, Asian nationalism. London: Routledge, 2000, x + 210 pp. -David van Duuren, Joseph Fischer ,The folk art of Bali; The narrative tradition. Kuala Lumpur: Oxford University Press, 1998, xx + 116 pp., Thomas Cooper (eds -Cassandra Green, David J. Stuart-Fox, Pura Besakih; Temple, religion and society in Bali. Leiden: KITLV Press, xvii + 470 pp. [Verhandelingen 193.] -Hans Hägerdal, Vladimir I. Braginsky ,Images of Nusantara in Russian literature. Leiden: KITLV Press, 1999, xxvi + 516 pp., Elena M. Diakonova (eds -Hans Hägerdal, David Chandler, A history of Cambodia (third edition. Boulder

Evaluation of Factor V Leiden, Prothrombin G20210A, MTHFR C677T and MTHFR A1298C gene polymorphisms in retinopathy of prematurity in a Turkish cohort.

Science.gov (United States)

Aydin, Hatip; Gunay, Murat; Celik, Gokhan; Gunay, Betul Onal; Aydin, Umeyye Taka; Karaman, Ali

2016-12-01

To assess Factor V Leiden (FVL) (rs6025), Prothrombin G20210A (rs1799963), MTHFR C677T (rs1801133), and MTHFR A1298C (rs1801131) gene mutations as risk factors in the development of retinopathy of prematurity (ROP). A total of 105 children were included in this cross-sectional study. Patients were divided into two groups. The study group consisted of 55 infants with a history of ROP and the control group comprised 50 healthy infants with term birth. All subjects were screened for the presence of certain mutations (FVL, Prothrombin G20210A, MTHFR C677T and MTHFR A1298C) by Real-Time PCR at 1 year of age. The mean gestational age (GA) and birth weight (BW) of the study group were, 28.65 ± 2.85 weeks and 1171 ± 385.74 g, respectively. There were no significant differences of genotype and allele frequency of Prothrombin G20210A, MTHFR A1298C and MTHFR C677T between the study and control groups (p > 0.05). Eight children (14.5 %) had heterozygous and one child (1.8%) had homozygous FVL mutation in the study group. One child (2%) in the control group had heterozygous FVL mutation. There was statistically significant differences of FVL allele and genotype frequencies between the groups (p < 0.05). The prevalence of FVL polymorphism (16.3 %) was higher in ROP patients than control subjects in this Turkish cohort. We suggest a possible association of FVL mutation with ROP at the end of the study.

Erratum to : Daphnia revisited: local stability and bifurcation theory for physiologically structured population models explained by way of an example (Journal of Mathematical Biology, , 61, 2, (277-318), 10.1007/s00285-009-0299-y)

NARCIS (Netherlands)

Diekmann, Odo; Gyllenberg, Mats; Metz, J. A.J.; Nakaoka, Shinji; de Roos, André M.

2017-01-01

In the original publication, the addresses of the authors Dr. J.A.J. Metz and Dr. S. Nakaoka were incorrectly published. The correct address list for the authors are: J.A.J. Metz: Institute of Biology and Institute of Mathematics, Leiden University, P.O. Box 9516, 2300RA Leiden, The Netherlands. S.

Building a Green Metropolis. Costs and impacts. Plan of the Dutch environmental organization Milieudefensie; Bouwen aan een Groene Metropool. Kosten en effecten. Plan van Milieudefensie

Energy Technology Data Exchange (ETDEWEB)

Doenszelmann, C.E.P.; Schroten, A.

2011-05-15

The plan of the Dutch environmental organization Milieudefensie contains various proposals for a more sustainable realization of accessibility in the Rotterdam region. CE Delft mapped the costs and environmental effects of these proposals. [Dutch] In het plan van Milieudefensie worden verschillende voorstellen gedaan om tot een duurzamere invulling van de bereikbaarheid in de Rotterdamse regio te komen. CE Delft heeft de kosten en de milieueffecten van deze voorstellen in beeld gebracht.

Quiggin's Rank Dependent Model. Review of Generalized Expected Utility Theory: The Rank-Dependent Model, by John Quiggin

OpenAIRE

Wakker, Peter

1994-01-01

textabstractJohn Quiggin is a professor at the centre for Economic Policy Research of the Australian National University. His research interests are decision making under risk and agricultural economics. The reviewer is an associate professor at the Medical Decision Making Unit, University of Leiden, Leiden, The Netherlands. His main interest is decision making under uncertainty.

Could hands-on activities and smartphone in science CLIL teaching foster motivation and positive attitudes in students?

Science.gov (United States)

Ercolino, Immacolata; Maraffi, Sabina; Sacerdoti, Francesco M.

2016-04-01

Motivating students is one of the most challenging things we do as educators. We know that students need to be engaged to fully appreciate and learn what has been taught; the secret consists in nurturing student engagement. One of the newer ways to involve students and foster motivation in their Science learning consists in focusing on their usage and on applying knowledge and skills in their real-life. Students usually are engaged in authentic teaching pathway. Learning focusing on the experience helps teachers to improve classroom management by gathering students around a common organized activity. Hands-on activities support problem-based approaches to learning by focusing on the experience and process of investigating, proposing and creating solutions developing critical thinking skills and enlarge student's scientific glossary. We utilized in our classroom some lab activities that we learned at an ESA/GTTP Teacher training Workshop 2014 program at the Lorentz Center Leiden, Netherlands. "Cooking a comet - Ingredients for life" "Demonstration of the second Kepler's law using marbles" New media equipment, as student's own smartphones, can increase the teaching impact speaking the same language used by the students every day. They can measure magnetic fields, their GPS coordinates (longitude and latitude), and so on. In this way we can measure distances as parallax using mobile devices and simulating distance measurements in the classroom, on the school campus. The smartphone is the device with which the students answer questions, take decisions, and solve quests. Students infact can observe the Universe from their classroom and scientifically they can watch the Sun with "Google sky map" or "Star walk" are excellent tools to learn your way around the night sky .As teachers we used these apps in the classroom when Sun goes through the constellations so our students don't believe in horoscopes. This paper is focused on hands on activities and the effects of the

Jan Hendrik Oort – A Complete Astronomer (1900 –1992)

Indian Academy of Sciences (India)

IAS Admin

to Leiden to give secret lectures to his loyal students. One of the topics he worked on after joining the Leiden Observatory was to confirm earlier speculations about the rotation of our Galaxy. He analyzed the motions of distant stars and found that our Galaxy rotates differentially, the inner parts moved ahead of the outer parts ...

Numerical simulation of the hydrodynamic processes in the Red Sea Region

OpenAIRE

Madah, Fawaz

2017-01-01

The semi-enclosed Red Sea basin presents a unique large marine ecosystem. Therefore it deserves scientific attention. The processes under concern are studied using a combination of very few available observations (water levels and oceanographic data), remotely sensed data as well as numerical modelling approach. The numerical simulations are performed using the three-dimensional modeling system Delft3D, developed by WL | Delft Hydraulics. The first part of the present thesis investigates ...

Spectrum Fatigue of 7075-T651 Aluminum Alloy under Overloading and Underloading

Science.gov (United States)

2016-03-15

Ewalds: Report, Delft University of Technology, Dept. of Metallurgy , Delft, The Nethermands, Oct 1978. 14. P. Bristol, and J. A. Roeleveld: in...Proceedings, European Offshore Steels Research Seminar, The Welding Institute, Abbington Hall, Abbington, Cambridge, U. K., 1980, pp. VI/p. 18-1- VI/p. 18... Welding Institute, Abbington Hall, Abbington, Cambridge, U. K., 1980, pp. VI/p. 15-VI/p. 15-15. 16. J. C. Radon, C. M. Branco, and L. E. Culver

Information Science: Science or Social Science?

OpenAIRE

Sreeramana Aithal; Paul P.K.,; Bhuimali A.

2017-01-01

Collection, selection, processing, management, and dissemination of information are the main and ultimate role of Information Science and similar studies such as Information Studies, Information Management, Library Science, and Communication Science and so on. However, Information Science deals with some different characteristics than these subjects. Information Science is most interdisciplinary Science combines with so many knowledge clusters and domains. Information Science is a broad disci...

Effects of probiotic Lactobacillus rhamnosus GG and Propionibacterium freudenreichii ssp. shermanii JS supplementation on intestinal and systemic markers of inflammation in ApoE*3Leiden mice consuming a high-fat diet.

Science.gov (United States)

Oksaharju, Anna; Kooistra, Teake; Kleemann, Robert; van Duyvenvoorde, Wim; Miettinen, Minja; Lappalainen, Jani; Lindstedt, Ken A; Kovanen, Petri T; Korpela, Riitta; Kekkonen, Riina A

2013-07-14

A high-fat diet disturbs the composition and function of the gut microbiota and generates local gut-associated and also systemic responses. Intestinal mast cells, for their part, secrete mediators which play a role in the orchestration of physiological and immunological functions of the intestine. Probiotic bacteria, again, help to maintain the homeostasis of the gut microbiota by protecting the gut epithelium and regulating the local immune system. In the present study, we explored the effects of two probiotic bacteria, Lactobacillus rhamnosus GG (GG) and Propionibacterium freudenreichii spp. shermanii JS (PJS), on high fat-fed ApoE*3Leiden mice by estimating the mast cell numbers and the immunoreactivity of TNF-α and IL-10 in the intestine, as well as plasma levels of several markers of inflammation and parameters of lipid metabolism. We found that mice that received GG and PJS exhibited significantly lower numbers of intestinal mast cells compared with control mice. PJS lowered intestinal immunoreactivity of TNF-α, while GG increased intestinal IL-10. PJS was also observed to lower the plasma levels of markers of inflammation including vascular cell adhesion molecule 1, and also the amount of gonadal adipose tissue. GG lowered alanine aminotransferase, a marker of hepatocellular activation. Collectively, these data demonstrate that probiotic GG and PJS tend to down-regulate both intestinal and systemic pro-inflammatory changes induced by a high-fat diet in this humanised mouse model.

Curating Research: e-Merging New Roles and Responsibilities in the European Landscape (Conference Report

Directory of Open Access Journals (Sweden)

Inge Angevaare

2009-11-01

Full Text Available On 17 April 2009 LIBER, the Koninklijke Bibliotheek (KB and the Netherlands Coalition for Digital Preservation (NCDD co-organised LIBER’s first workshop on digital curation/preservation, providing an introduction to the theme of digital curation and different perspectives on the roles research libraries can and/or must play in keeping the digital records of science safe for future generations. Speakers included Eileen Fenton (Portico, Dale Peters (DRIVER, Maria Heijne (TU Delft Library, Jeffrey van der Hoeven (KB, PARSE.insight and ninety workshop attendees. The paper includes the conference report and some results of the PARSE.insight online survey into digital preservation practices of LIBER libraries.

A Real-Time Nearshore Wave and Current Prediction System

Science.gov (United States)

2008-01-01

this component of the The Dclfl3D system, developed by Delft Hydraulics nearshorc modeling system was tailored specifically tbr ( htp :,’www.wldelft.nl...Walstra. DA-., 2004. Keeping it simple by using Tolman. ILL., 2002. U.ser Manual and Systrn [Documentation of complex models, The 6th tnt. Conf. an...Stelling, 6.S., Van Kester, J.A.TM., 1994. Otil the approximation of WL D)elft I lvdratifis. 2001. User Manual l)MIUD-FLIAW. horizontal gradients in

Editorial: Driving, cycling and flying: Trends in planning and operational transportation research in Europe

OpenAIRE

Homem de Almeida Correia, G.; Lopes dos Santos, Bruno F.; Kroesen, M.

2017-01-01

In this special issue we present three papers selected from the 18th meeting of the EURO Working Group on Transportation (EWGT) which was held in July 2015 in Delft, the Netherlands, organized by Delft University of Technology. The selected contributions reflect the diversity of topics that were addressed in this conference, which is dedicated to mathematical modeling of transportation problems. We are happy to have a small but representative sample in which three different modes of transport...

Three Giants in the Cradle of Reproductive Medicine; Reproduction Theories of the Seventeenth Century as Discerned by Pregnancy Portraiture in the Oeuvre of Jan Vermeer

Directory of Open Access Journals (Sweden)

Ronit Haimov-Kochman

2016-04-01

Full Text Available Portraits of pregnant women are rare in Catholic Renaissance art. In seventeenth-century Holland, the Catholic rule of Spain had been thrown off and a Protestant Calvinistic republic emerged, freeing Dutch artists to choose an unorthodox subject matter for their paintings. The Golden Age of Holland was characterized by extreme wealth, originating from overseas trade, which fostered a marked interest in philosophy, science, medicine, as well as art. Despite this, portraiture of pregnancy remained uncommon. An exception to this rule was Jan Vermeer of Delft, who lived during the zenith of this era. Jan Vermeer painted fewer than 40 pictures, fathered 15 children, and died bankrupt and little appreciated at the age of 43. Vermeer confined himself almost entirely to images of women in various domestic situations, including three figures of pregnant women. In this framework, pregnancy could be viewed as an icon for fidelity and conformism to social expectations. In this paper we investigate the roots of this unusual icon in Vermeer’s oeuvre, and suggest that the use of pregnancy in his paintings could have been inspired by his Delft-resident contemporaries Antony van Leeuwenhoek and Reinier de Graaf, fathers of well-known and opposing theories of reproduction. These eminent scientists and Vermeer’s pregnant wife, who frequently served as his model, might have made pregnancy less mysterious and more realistic to the painter.

Field analysis of two-dimensional focusing grating

OpenAIRE

Borsboom, P.P.; Frankena, H.J.

1995-01-01

The method that we have developed [P-P. Borsboom, Ph.D. dissertation (Delft University of Technology, Delft, The Netherlands); P-P. Borsboom and H. J. Frankena, J. Opt. Soc. Am. A 12, 1134–1141 (1995)] is successfully applied to a two-dimensional focusing grating coupler. The field in the focal region has been determined for symmetrical chirped gratings consisting of as many as 124 corrugations. The intensity distribution in the focal region agrees well with the approximate predictions of geo...

Supporting home based health care in South African rural communities using USSD technology

CSIR Research Space (South Africa)

Wouters, B

2009-08-01

Full Text Available . The proposed solution was a remote monitoring system, which facilitated transmission of patient information from caregiver to clinic sister. One of the main challenges of the project was to understand the social context of the problem and embodiment... the Dutch University of Technology Delft (TU Delft) and the South African Council for Scientific and Industrial Research (CSIR). The prototype, a USSD application on caregivers’ mobile phones (a sort of ‘interactive SMS’), was mainly used to study users...

Sustainable building; Duurzaam bouwen

Energy Technology Data Exchange (ETDEWEB)

Hendriks, Ch.F. [ed.] [Interfacultair Onderzoek Centrum ' De Ecologische Stad' DIOC, Delft (Netherlands)

1999-07-01

A complete overview is given of starting points and targets for the sustainable construction of buildings. The notion of sustainable indicates the necessity of managing specific flows: materials, energy, water and transport (traffic). Also, the monitoring and calculation of environmental effects must be clarified by the generally accepted method of life cycle analysis. This book is for the larger part the result of research carried out at the Interdepartmental Research Centre 'The Ecological City' at the Delft University of Technology in Delft, Netherlands. refs.

Changes in nearshore waves during the active sea/land breeze period off Vengurla, central west coast of India

Digital Repository Service at National Institute of Oceanography (India)

Amrutha, M.M.; SanilKumar, V.; Singh, J.

zones with use of mechanized boats and this area is also extensively used for tourism-related activities. Therefore, it is important to un- derstand the changes in wave parameters during the active land/sea breeze system in the nearshore region... and interaction. The wave computations in Delft3D-wave are stable due to the fully implicit schemes that have been implemented. In the Delft3D-wave module, the governing equation of wave transformation is based on action balance spectrum, in ge- ographical space...

Book Reviews

OpenAIRE

Mary Somers Heidhues; U. Wikan; Henk Schulte Nordholt; Gehan Wijeyewardene; Oscar Salemink; James J. Fox; Jerome Rousseau; H. Claessen; Ratna Saptari; Marijke Barend-van Haeften; Harry A. Poeze; Wolfgang Marschall; G.E. Marrison; H. den Hertog; A. M. Luyendijk-Elshout

1992-01-01

- Jet Bakels, Robert Layton, The anthropology of art. Cambridge: Cambridge University Press, 1991, 258 pp. - J.M.S. Baljon, Herman Leonard Beck, De Islam in Nederland: Romancing religion? [Inaugurele rede theologische faculteit Tilburg 14.2.1992.] Tilburg: Tilburg University Press 1992. - R.H. Barnes, J.D.M. Platenkamp, North Halmahera: Non-Austronesian Languages, Austronesian cultures?, Lecture presented to the Oosters Genootschap in Nederland at Leiden on 23 May 1989, Leiden: Oost...

Tim de Zeeuw to Become the Next Director General of ESO

Science.gov (United States)

2007-01-01

The ESO Council has just appointed Tim de Zeeuw, 50, as the next Director General of ESO, effective as of 1 September 2007, when the current Director General, Catherine Cesarsky will complete her mandate. ESO PR Photo 02/07 ESO PR Photo 03/07 Professor Tim de Zeeuw "ESO is Europe's flagship organisation for ground-based astronomy," said, Richard Wade, President of the ESO Council. "The ESO Council is very pleased that Professor de Zeeuw has accepted the task as its next Director General. He has played a key role over the last few years in developing a strategic vision for ESO, and I have every confidence that he will now lead the organisation in the realisation of that exciting vision." Tim de Zeeuw has an excellent record, both as a highly respected scientist and as a leader of an internationally recognised science institute in the Netherlands. He is Scientific Director of the Leiden Observatory, a research institute in the College of Mathematics and Natural Sciences of Leiden University. Tim de Zeeuw also has considerable experience as regards science policy issues. Catherine Cesarsky, ESO's current Director General commented: "Over the recent years, ESO has developed considerably with more activities and new member states, and with its ambitious project portfolio, ESO is clearly facing an exciting future. I shall be delighted to pass the baton to Tim de Zeeuw, who as a recent Council member is very familiar with our Organisation." "It is a great honour and an exciting challenge to lead this world-class organisation in the years to come in support of one of the most dynamic areas of science today," said de Zeeuw. "I look forward to overseeing the continued upgrading of the Very Large Telescope with the second-generation instrumentation and the completion of the ALMA project, and in particular to help developing the future European Extremely Large Telescope." Tim de Zeeuw's main research interests embrace the formation, structure and dynamics of galaxies

Bio-coke as an alternative to petroleum coke and metallurgical coke; Bio-cokes als alternatief voor petroleumcokes en metallurgische cokes

Energy Technology Data Exchange (ETDEWEB)

Croezen, H.J.; Van Lieshout, M. [CE Delft, Delft (Netherlands); Sevenster, M.N. [Sevenster Environmental Consultancy, Australian Capital Territory ACT (Australia)

2012-11-15

In the framework of elaborating the Dutch Roadmap Chemistry 2030), CE Delft has conducted an exploratory study for the Association of the Dutch Chemical Industry (VNCI) on the options of replacing (petroleum) coke in the chemical sector by biocokes. Coke is used as a reducing agent and/or raw material in four companies in the Dutch chemical industry (Tronox, ESD-SIC, Thermphos, Aluchemie). Replacing coke at these four companies can potentially yield a direct CO2 reduction of expectedly several hundreds of kilotons per year. For a first exploration of the options of bio-coke, CE Delft first conducted a desk study to get information on the quality and production costs for bio-coke. Subsequently, CE Delft had contact with the four chemical companies and a made a number of company visits. Moreover, the technical, economic and organizational capabilities, constraints and requirements with regard to a possible (partial) switch to biocokes have been explored. Based on the information available so far it can be concluded that biocokes seems to be a technically and economically interesting innovation. For implementation to finally take place, it is necessary to gain better insight in the technical and economic potential [Dutch] In verband met de uitwerking van de Routekaart Chemie 2030 heeft CE Delft voor VNCI een verkenning uitgevoerd naar de mogelijkheden voor vervanging van (petroleum)cokes in de chemische sector door biocokes. Cokes wordt gebruikt als reductiemiddel en/of grondstof bij een viertal bedrijven in de Nederlandse chemie (Tronox, ESD-SIC, Thermphos, Aluchemie). Het vervangen van cokes bij deze vier bedrijven kan in potentie een directe CO2-reductie van naar verwachting enkele honderden kilotonnen/jaar opleveren. Voor een eerste verkenning van de mogelijkheden van bio-cokes heeft CE Delft eerst een bureaustudie uitgevoerd naar informatie over kwaliteit van en productiekosten voor bio-cokes. Vervolgens heeft CE Delft contact gehad met de vier chemische

Space Weather in the Machine Learning Era: A Multidisciplinary Approach

Science.gov (United States)

Camporeale, E.; Wing, S.; Johnson, J.; Jackman, C. M.; McGranaghan, R.

2018-01-01

The workshop entitled Space Weather: A Multidisciplinary Approach took place at the Lorentz Center, University of Leiden, Netherlands, on 25-29 September 2017. The aim of this workshop was to bring together members of the Space Weather, Mathematics, Statistics, and Computer Science communities to address the use of advanced techniques such as Machine Learning, Information Theory, and Deep Learning, to better understand the Sun-Earth system and to improve space weather forecasting. Although individual efforts have been made toward this goal, the community consensus is that establishing interdisciplinary collaborations is the most promising strategy for fully utilizing the potential of these advanced techniques in solving Space Weather-related problems.

Improved real-time dosimetry using the radioluminescence signal from Al2O3:C

DEFF Research Database (Denmark)

Damkjær, Sidsel Marie Skov; Andersen, Claus Erik; Aznar, Marianne

2008-01-01

15th International Conference on Solid State Dosimetry Location: Delft Univ Technol, Delft, NETHERLANDS Date: JUL 08-13, 2007 Abstract: Carbon-doped aluminum oxide (Al2O3:C) is a highly sensitive luminescence material for ionizing radiation dosimetry, and it is well established that the optically...... to greatly reduce the influence of shallow traps in the range from 0 to 3 Gy and the RL dose-rate measurements with a time resolution of 0. 1 s closely matched dose-rate changes monitored with in ionization chamber. (c) 2007 Elsevier Ltd. All rights reserved....

Cognitive function in the oldest old: women perform better than men

OpenAIRE

van Exel, E; Gussekloo, J; de Craen, A J M; d Bootsma-van,; Houx, P; Knook, D; Westendorp, R

2001-01-01

OBJECTIVE—Limited formal education is associated with poor cognitive function. This could explain sex differences in cognitive function in the oldest old. Whether limited formal education explains differences in cognitive function between elderly women and men was explored.
METHODS—The Leiden 85-plus Study is a population based study investigating all 85 year old inhabitants of Leiden with an overall response rate of 87%. A sample of 599 participants were visited at their...

EDITORIAL: Announcing the 2007 Measurement Science and Technology Outstanding Paper Awards

Science.gov (United States)

Foss, John; Dewhurst, Richard; Fujii, Kenichi; Regtien, Paul

2008-05-01

Since 1991, Measurement Science and Technology has awarded a Best Paper prize. The Editorial Board of this journal believes that such a prize is an opportunity to thank authors for submitting their work, and serves as an integral part of the on-going quality review of the journal. The current breadth of topical areas that are covered by MST has made it advisable to expand the recognition of excellent publications. Hence, since 2005 the Editorial Board have presented 'Outstanding Paper Awards' in four subject categories: Fluid Mechanics; Measurement Science; Precision Measurements; and Sensors and Sensing Systems. 2007 Award Winners—Fluid Mechanics An adaptive sampling and windowing interrogation method in PIV R Theunissen, F Scarano and M L Riethmuller von Karman Institute for Fluid Dynamics, Chaussée de Waterloo 72, 1640 Sint-Genesius Rode, Belgium and Department of Aerospace Engineering, Delft University of Technology, Delft, PO Box 5058, 2600 GB Delft, The Netherlands The co-authored paper [1] has been selected as the Outstanding Paper in Fluid Mechanics for 2007. This paper provides a strategy whereby the placement and the size of the interrogation regions are adapted to the image signal strength (seeding density) and the spatial variations of the velocity magnitudes. Two, quite distinct, test cases demonstrate the efficacy of their method: a shockwave- boundary layer interaction and an aircraft vortex wake. The Selection Committee—Drs T Fansler, J Foss, I Marusic, S Morris, K Okamoto and M Wernet—selected this paper from a strongly competitive shortlist of four candidates. Their selection process was influenced by the perceived utility of the contribution to the numerous investigators who utilize PIV methods. 2007 Award Winners—Measurement Science Broadband single cell impedance spectroscopy using maximum length sequences: theoretical analysis and practical considerations Tao Sun, Shady Gawad, Catia Bernabini, Nicolas G Green and Hywel Morgan

Science and Science Fiction

Science.gov (United States)

Oravetz, David

2005-01-01

This article is for teachers looking for new ways to motivate students, increase science comprehension, and understanding without using the old standard expository science textbook. This author suggests reading a science fiction novel in the science classroom as a way to engage students in learning. Using science fiction literature and language…

Do Gender-Science Stereotypes Predict Science Identification and Science Career Aspirations among Undergraduate Science Majors?

Science.gov (United States)

Cundiff, Jessica L.; Vescio, Theresa K.; Loken, Eric; Lo, Lawrence

2013-01-01

The present research examined whether gender-science stereotypes were associated with science identification and, in turn, science career aspirations among women and men undergraduate science majors. More than 1,700 students enrolled in introductory science courses completed measures of gender-science stereotypes (implicit associations and…

Peripheral Auditory Mechanisms

CERN Document Server

Hall, J; Hubbard, A; Neely, S; Tubis, A

1986-01-01

How weIl can we model experimental observations of the peripheral auditory system'? What theoretical predictions can we make that might be tested'? It was with these questions in mind that we organized the 1985 Mechanics of Hearing Workshop, to bring together auditory researchers to compare models with experimental observations. Tbe workshop forum was inspired by the very successful 1983 Mechanics of Hearing Workshop in Delft [1]. Boston University was chosen as the site of our meeting because of the Boston area's role as a center for hearing research in this country. We made a special effort at this meeting to attract students from around the world, because without students this field will not progress. Financial support for the workshop was provided in part by grant BNS- 8412878 from the National Science Foundation. Modeling is a traditional strategy in science and plays an important role in the scientific method. Models are the bridge between theory and experiment. Tbey test the assumptions made in experim...

Activity Based Carboning (ABCO2). Automatic calculation of CO2 emission at consignment level; Activity Based Carboning (ABCO2). Automatische berekening van de CO2-uitstoot op zending niveau

Energy Technology Data Exchange (ETDEWEB)

Den Boer, L.C.

2012-11-15

In a collaborative effort with the CAPE group, CE Delft has developed ABCO2: a tool for calculating the carbon emissions of logistics operations at the level of individual consignments. The tool can be used during order make-up to indicate the CO2 emissions of available alternatives. To this end the user defines a network, providing details on vehicle fleet, logistic characteristics and transhipment locations. By filling in order data over an extended period, the effect of opting for a different modality or bundling shipments can be quantified. CE Delft helped develop the calculation methodology for the tool and provided the emission indices used in the model, in which relevant existing standards have also been incorporated [Dutch] Samen met CAPE groep heeft CE Delft de tool ABCO2 ontwikkeld. Met deze tool is het mogelijk om op orderniveau de emissies van logistieke activiteiten te berekenen. De tool wordt gebruikt tijdens het orderproces, en geeft bij het aanmaken van een order de CO2 uitstoot van verschillende alternatieven weer. De gebruiker richt zelf een netwerk in, en detailleert dit door een wagenpark, logistieke karakteristieken, en locaties voor overslag te definiëren. Met ordergegevens over langere tijd kan ook het effect van keuzes voor een andere modaliteit, of het bundelen van zendingen gekwantificeerd worden. CE Delft heeft meegeholpen om de rekenmethodiek van de tool te ontwikkelen en heeft emissiekentallen aangeleverd, die in het model zijn opgenomen. Bij de ontwikkeling van het model is rekening gehouden met de beschikbare standaarden hiervoor.

Science of science.

Science.gov (United States)

Fortunato, Santo; Bergstrom, Carl T; Börner, Katy; Evans, James A; Helbing, Dirk; Milojević, Staša; Petersen, Alexander M; Radicchi, Filippo; Sinatra, Roberta; Uzzi, Brian; Vespignani, Alessandro; Waltman, Ludo; Wang, Dashun; Barabási, Albert-László

2018-03-02

Identifying fundamental drivers of science and developing predictive models to capture its evolution are instrumental for the design of policies that can improve the scientific enterprise-for example, through enhanced career paths for scientists, better performance evaluation for organizations hosting research, discovery of novel effective funding vehicles, and even identification of promising regions along the scientific frontier. The science of science uses large-scale data on the production of science to search for universal and domain-specific patterns. Here, we review recent developments in this transdisciplinary field. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Science and data science.

Science.gov (United States)

Blei, David M; Smyth, Padhraic

2017-08-07

Data science has attracted a lot of attention, promising to turn vast amounts of data into useful predictions and insights. In this article, we ask why scientists should care about data science. To answer, we discuss data science from three perspectives: statistical, computational, and human. Although each of the three is a critical component of data science, we argue that the effective combination of all three components is the essence of what data science is about.

Environmental performances of gas pipe materials

International Nuclear Information System (INIS)

Van Nifterik, G.

1996-01-01

In constructing new gas pipelines energy distribution companies are increasingly dealing with the question of which material has the lowest environmental impact. Gastec (Dutch gas research institute) and the 'Centrum voor Milieukunde Leiden' (Centre for Environmental Studies of the University of Leiden) studied and compared the environmental aspects of such materials. The study concerns the entire life cycle from raw materials production through digging and welding or fusion joining to the moment the materials are discarded as waste. 2 figs

The IAEA collaborating centre for neutron activation based methodologies of research reactors

International Nuclear Information System (INIS)

Bode, P.

2010-01-01

The Reactor Institute Delft of the Delft University of Technology houses the Netherlands' only academic nuclear research reactor, with associated instrumentation and laboratories, for scientific education and research with ionizing radiation. The Institute's swimming pool type research reactor reached first criticality in 1963 and is currently operated at 2MW thermal powers on a 100 h/week basis. The reactor is equipped with neutron mirror guides serving ultra modern neutron beam physics instruments and with a very bright positron facility. Fully automated gamma-ray spectrometry systems are used by the laboratory for neutron activation analysis, providing large scale services under an ISO/IEC 17025:2005 compliant management system, being (since 1993) the first accredited laboratory of its kind in the world. Already for several years, this laboratory is sustainable by rendering these services to both the public and the private sector. The prime user of the Institute's fac ilities is the scientific Research Department of Radiation, Radionuclide and Reactors of the Faculty of Applied Sciences, housed inside the building. All reactor facilities are also made available for use by or for services to, external clients (industry, government, private sector, other (international research institutes and universities). The Reactor Institute Delft was inaugurated in May 2009 as a new lAEA Collaborating Centre for Neutron Activation Based Methodologies of Research Reactors. The collaboration involves education, research and development in (I) Production of reactor-produced, no-carrier added radioisotopes of high specific activity via neutron activation; (II) Neutron activation analysis with emphasis on automation as well as analysis of large samples, and radiotracer techniques and as a cross-cutting activity, (IIl) Quality assurance and management in research and application of research reactor based techniques and in research reactor operations. This c ollaboration will

Primary Science Interview: Science Sparks

Science.gov (United States)

Bianchi, Lynne

2016-01-01

In this "Primary Science" interview, Lynne Bianchi talks with Emma Vanstone about "Science Sparks," which is a website full of creative, fun, and exciting science activity ideas for children of primary-school age. "Science Sparks" started with the aim of inspiring more parents to do science at home with their…

WOP '89

International Nuclear Information System (INIS)

1989-01-01

The Interfaculty Reactor Institute is an interfaculty research institute of the Technical University Delft. The faculties involved are those of Technical Physics, Chemical Technology and Material Sciences, of which the first one acts as conducting faculty. Research and education take place in four departments: Radiochemistry, Radiation chemistry, Radiation physics and Reactor physics. In this report the working-programmes involved for the year 1989 and the development-programmes 1990-1993 are presented. Also the projects of the section Instrumentation Radiation-research of the group Spectroscopy and Radiation-technology of the faculty of Technical Physics have been token up briefly. The projects of the supporting services and oepration groups are indicated. The estimates are presented apart from the working-/development-programme. (author). 9 tabs

Caring Science or Science of Caring.

Science.gov (United States)

Turkel, Marian C; Watson, Jean; Giovannoni, Joseph

2018-01-01

The concepts caring science and science of caring have different meanings; however, they are often used interchangeably. The purpose of this paper is to present an overview of the synthesis of the scholarly literature on the definitions of the science of caring and caring science and to affirm the authors' perspective relating to the language of caring science. Caring science advances the epistemology and ontology of caring. Ideas related to caring science inquiry are presented, and the authors acknowledge the future of caring science as unitary caring science.

What's science? Where's science? Science journalism in German print media.

Science.gov (United States)

Summ, Annika; Volpers, Anna-Maria

2016-10-01

This article examines the current state of science coverage in German print media. It deals with the following questions: (1) how the main characteristics of science journalism can be described, (2) whether there is a difference between various scientific fields, and (3) how different definitions of science journalism lead to differing findings. Two forms of science coverage were analyzed in a standardized, two-part content analysis of German newspapers (N = 1730 and N = 1640). The results show a significant difference between a narrow and a broad definition of science journalism. In the classic understanding, science journalism is prompted by scientific events and is rather noncritical. Science coverage in a broad sense is defined by a wider range of journalistic styles, driven by non-scientific events, and with a focus on the statements of scientific experts. Furthermore, the study describes the specific role of the humanities and social sciences in German science coverage. © The Author(s) 2015.

Science Fiction and Science Education.

Science.gov (United States)

Cavanaugh, Terence

2002-01-01

Uses science fiction films such as "Jurassic Park" or "Anaconda" to teach science concepts while fostering student interest. Advocates science fiction as a teaching tool to improve learning and motivation. Describes how to use science fiction in the classroom with the sample activity Twister. (YDS)

Scope of activities and organization of an interuniversity reactor institute

International Nuclear Information System (INIS)

de Bruin, M.

1990-01-01

The Reactor Instituut Delft was founded in 1958 and was at that time part of the Delft University of Technology. In 1969, the institute was converted into an interuniversity institute, owned and directed by the combined Dutch universities. Since 1987, the institute has again constituted part of the Delft University of Technology, still continuing its role as an interuniversity institute and with provisions in the organizational structure to secure this role. The major facility of the institute is the Hoger Onderwijs reactor, a 2-MW swimming pool reactor operated 24 h/day, 5 days/week. The reactor is used in neutron beam studies, reactor physics research, and for isotope production, neutron activation analysis (NAA), and commercial irradiation. The institute's 3-MeV Van de Graaff electron accelerator is mainly used for radiation chemistry. It can deliver subnanosecond high-current pulses and is provided with fast optical and conductivity measuring equipment. The variable energy positron source is being used for the study of defects at metal surfaces and interfaces. The experience obtained with this source is used in the development of a much stronger source as the basis of a positron microbeam in one of the reactor beam tubes

Preservice Science Teachers' Science Teaching Orientations and Beliefs about Science

Science.gov (United States)

Kind, Vanessa

2016-01-01

This paper offers clarification of science teacher orientations as a potential component of pedagogical content knowledge. Science teaching orientations and beliefs about science held by 237 preservice science teachers were gathered via content-specific vignettes and questionnaire, respectively, prior to participation in a UK-based teacher…

Formative science and indicial science: epistemological proposal for information science

Directory of Open Access Journals (Sweden)

Eliany Alvarenga de Araújo

2006-07-01

Full Text Available Epistemological reflections on the Information Science as scientific field that if structure in the context of modern science, in theoretical and methodological terms and technologies of the information in applied terms. Such configuration made possible the sprouting of this science; however we consider that the same one will not guarantee to this science the full development as field of consistent and modern knowledge. Modern Science, while scientific practical vision and meets depleted and the information technologies are only auto-regulated mechanisms that function according to principles of automatisms. To leave of these considerations we propols the concept of Formative Science (Bachelard, 1996 and the Indiciario Paradigm (1991 with epistemological basis for the Information Science. The concept of formative science if a base on the principles of tree states of the scientific spirit and the psychological condition of the scientific progress and the indiciario paradigm it considers the intuição (empirical and rational as methodological base to make it scientific.

Book Reviews

Directory of Open Access Journals (Sweden)

Redactie KITLV

2005-01-01

Full Text Available -Monika Arnez, Niels Mulder, Southeast Asian images; Towards civil society? Chiang Mai: Silkworm Books, 2003, ix + 253 pp. -Adriaan Bedner, Connie Carter, Eyes on the prize; Law and economic development in Singapore. The Hague: Kluwer Law International, xviii + 307 pp. [The London-Leiden series on law, administration and development 7.] -Amrit Gomperts, J.R. van Diessen ,Grote atlas van Nederlands Oost-Indië/Comprehensive atlas of the Netherlands East Indies. Zierikzee: Asia Maior, Utrecht: Koninklijk Nederlands Aardrijkskundig Genootschap (KNAG, 2004, 480 pp. (editors, with the collaboration of R.C.M. Braam, W. Leijnse, P.A. Levi, J.J. Reijnders, R.P.G.A. Voskuil and M.P.B. Ziellemans, F.J. Ormeling (eds -Stuart R. Harrop, Adriaan Bedner ,Towards integrated environmental law in Indonesia? Leiden: Research school CNWS, School of Asian, African and Amerindian studies, 2003, 161 pp. [CNWS publications 127.], Nicole Niessen (eds -David Henley, Paul H. Kratoska ,Locating Southeast Asia: Geographies of knowledge and politics of space. Singapore: Singapore University Press, 2005, xi + 326 pp., Remco Raben, Henk Schulte Nordholt (eds -Gerry van Klinken, Anthony J. Langlois, The politics of justice and human rights; Southeast Asia and universalist theory. Cambridge: Cambridge University Press, 2001, xi + 214 pp. [Cambridge Asia-Pacific studies.] -Koh Keng We, Jurrien van Goor, Prelude to colonialism; The Dutch in Asia. Hilversum: Verloren, 2004, 127 pp. -Lim Beng Soon, Thomas H. Slone, Prokem; An analysis of a Jakartan slang. Oakland: Masalai Press, 2003, 95 pp. -Lim Beng Soon, Neil Khor Jin Keong ,The Penang Po Leung Kuk; Chinese women, prostitution and a welfare organisation. Kuala Lumpur; The Malaysian branch of the Royal Asiatic society (MBRAS, 2004, VII + 181 pp., Khoo Keat Siew (eds -Dick van der Meij, J. Thomas Lindblad ,Macht en majesteit; Opstellen voor Cees Fasseur bij zijn afscheid als hoogleraar in de geschiedenis van Indonesië aan de

Everyday science & science every day: Science-related talk & activities across settings

Science.gov (United States)

Zimmerman, Heather

To understand the development of science-related thinking, acting, and learning in middle childhood, I studied youth in schools, homes, and other neighborhood settings over a three-year period. The research goal was to analyze how multiple everyday experiences influence children's participation in science-related practices and their thinking about science and scientists. Ethnographic and interaction analysis methodologies were to study the cognition and social interactions of the children as they participated in activities with peers, family, and teachers (n=128). Interviews and participant self-documentation protocols elucidated the participants' understandings of science. An Everyday Expertise (Bell et al., 2006) theoretical framework was employed to study the development of science understandings on three analytical planes: individual learner, social groups, and societal/community resources. Findings came from a cross-case analysis of urban science learners and from two within-case analyses of girls' science-related practices as they transitioned from elementary to middle school. Results included: (1) children participated actively in science across settings---including in their homes as well as in schools, (2) children's interests in science were not always aligned to the school science content, pedagogy, or school structures for participation, yet children found ways to engage with science despite these differences through crafting multiple pathways into science, (3) urban parents were active supporters of STEM-related learning environments through brokering access to social and material resources, (4) the youth often found science in their daily activities that formal education did not make use of, and (5) children's involvement with science-related practices can be developed into design principles to reach youth in culturally relevant ways.

Book Reviews

Directory of Open Access Journals (Sweden)

Mary Somers Heidhues

1992-07-01

in Atjeh, 1873-1904. Amsterdam, Thesis Publishers, 1991. - G.E. Marrison, Wolfgang Marschall, The Rejang of South Sumatra. Hull: Centre for South-east Asian Studies, 1992, iii + 93 pp., ill. (Occasional Papers no. 19: special issue., Michele Galizia, Thomas M. Psota (eds. - Harry A. Poeze, Marijke Barend-van Haeften, Oost-Indie gespiegeld; Nicolaas de Graaff, een schrijvend chirurgijn in dienst van de VOC. Zutphen: Walburg Pers, 1992, 279 pp. - Ratna Saptari, H. Claessen, Het kweekbed ontkiemd; Opstellen aangeboden aan Els Postel. Leiden: VENA, Faculty of Social Sciences, University of Leiden, P.O. Box 9555, 2300 RA., M. van den Engel, D. Plantenga (eds. - Jerome Rousseau, James J. Fox, The heritage of traditional agriculture among the western Austronesians. Occasional paper of the department of Anthropology. Comparitive Austronesian Project. Research school of Pacific studies. Australian National University, Canberra, Australia, 1992. 89 pp. - Oscar Salemink, Gehan Wijeyewardene, Ethnic groups acrss National boundaries in mainland Southeast Asia. Singapore 1990, Institute of Southeast Asian studies (Social issues in Southeast Asia series. x + 192 pp. - Henk Schulte Nordholt, U. Wikan, Managing turbulent hearts. A Balinese formula for living, Chicago: University of Chicago Press. 1990, xxvi + 343 pp. photos. - Mary Somers Heidhues, Claudine Salmon, Le moment ‘sino-malais’ de la litterature indonesienne. [Cahier d’Archipel 19.] Paris: Association Archipel, 1992. - Heather Sutherland, J.N.F.M. à Campo, Koninklijke Paketvaart Maatschappij; Stoomvaart en staatsvorming in de Indonesische archipel 1888-1914, Hilversum: Verloren, (Erasmus Universiteit Rotterdam, Publikaties van de Faculteit der Historische en Kunstwetenschappen III, 1992, 756 pp., tables, graphics, photographs. - Gerard Termorshuizen, Robin W. Winks, Asia in Western fiction. Honolulu: University of Hawaii Press, 1990. x + 229 pp., James R. Rush (eds. - John Verhaar, Lourens de Vries, The

Testing statistical hypotheses

CERN Document Server

Lehmann, E L

2005-01-01

The third edition of Testing Statistical Hypotheses updates and expands upon the classic graduate text, emphasizing optimality theory for hypothesis testing and confidence sets. The principal additions include a rigorous treatment of large sample optimality, together with the requisite tools. In addition, an introduction to the theory of resampling methods such as the bootstrap is developed. The sections on multiple testing and goodness of fit testing are expanded. The text is suitable for Ph.D. students in statistics and includes over 300 new problems out of a total of more than 760. E.L. Lehmann is Professor of Statistics Emeritus at the University of California, Berkeley. He is a member of the National Academy of Sciences and the American Academy of Arts and Sciences, and the recipient of honorary degrees from the University of Leiden, The Netherlands and the University of Chicago. He is the author of Elements of Large-Sample Theory and (with George Casella) he is also the author of Theory of Point Estimat...

WikiScience: Wikipedia for science and technology

OpenAIRE

Aibar Puentes, Eduard

2015-01-01

Peer-reviewed Presentació de la conferència "WikiScience: Wikipedia for science and technology". Presentación de la conferencia "WikiScience: Wikipedia for science and technology". Presentation of the conference "Science Wiki: Wikipedia for science and technology".

Where civics meets science: building science for the public good through Civic Science.

Science.gov (United States)

Garlick, J A; Levine, P

2017-09-01

Public understanding of science and civic engagement on science issues that impact contemporary life matter more today than ever. From the Planned Parenthood controversy, to the Flint water crisis and the fluoridation debate, societal polarization about science issues has reached dramatic levels that present significant obstacles to public discussion and problem solving. This is happening, in part, because systems built to support science do not often reward open-minded thinking, inclusive dialogue, and moral responsibility regarding science issues. As a result, public faith in science continues to erode. This review explores how the field of Civic Science can impact public work on science issues by building new understanding of the practices, influences, and cultures of science. Civic Science is defined as a discipline that considers science practice and knowledge as resources for civic engagement, democratic action, and political change. This review considers how Civic Science informs the roles that key participants-scientists, public citizens and institutions of higher education-play in our national science dialogue. Civic Science aspires to teach civic capacities, to inform the responsibilities of scientists engaged in public science issues and to inspire an open-minded, inclusive dialogue where all voices are heard and shared commitments are acknowledged. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Portraying Real Science in Science Communication

Science.gov (United States)

van Dijk, Esther M.

2011-01-01

In both formal and informal settings, not only science but also views on the nature of science are communicated. Although there probably is no singular nature shared by all fields of science, in the field of science education it is commonly assumed that on a certain level of generality there is a consensus on many features of science. In this…

Science teaching in science education

Science.gov (United States)

Callahan, Brendan E.; Dopico, Eduardo

2016-06-01

Reading the interesting article Discerning selective traditions in science education by Per Sund , which is published in this issue of CSSE, allows us to open the discussion on procedures for teaching science today. Clearly there is overlap between the teaching of science and other areas of knowledge. However, we must constantly develop new methods to teach and differentiate between science education and teaching science in response to the changing needs of our students, and we must analyze what role teachers and teacher educators play in both. We must continually examine the methods and concepts involved in developing pedagogical content knowledge in science teachers. Otherwise, the possibility that these routines, based on subjective traditions, prevent emerging processes of educational innovation. Modern science is an enormous field of knowledge in its own right, which is made more expansive when examined within the context of its place in society. We propose the need to design educative interactions around situations that involve science and society. Science education must provide students with all four dimensions of the cognitive process: factual knowledge, conceptual knowledge, procedural knowledge, and metacognitive knowledge. We can observe in classrooms at all levels of education that students understand the concepts better when they have the opportunity to apply the scientific knowledge in a personally relevant way. When students find value in practical exercises and they are provided opportunities to reinterpret their experiences, greater learning gains are achieved. In this sense, a key aspect of educational innovation is the change in teaching methodology. We need new tools to respond to new problems. A shift in teacher education is needed to realize the rewards of situating science questions in a societal context and opening classroom doors to active methodologies in science education to promote meaningful learning through meaningful teaching.

Secondary science teachers' attitudes toward and beliefs about science reading and science textbooks

Science.gov (United States)

Yore, Larry D.

Science textbooks are dominant influences behind most secondary science instruction but little is known about teachers' approach to science reading. The purpose of this naturalistic study was to develop and validate a Science and Reading Questionnaire to assess secondary science teachers' attitudes toward science reading and their beliefs or informed opinions about science reading. A survey of 428 British Columbia secondary science teachers was conducted and 215 science teachers responded. Results on a 12-item Likert attitude scale indicated that teachers place high value on reading as an important strategy to promote learning in science and that they generally accept responsibility for teaching content reading skills to science students. Results on a 13-item Likert belief scale indicated that science teachers generally reject the text-driven model of reading, but they usually do not have well-formulated alternative models to guide their teaching practices. Teachers have intuitive beliefs about science reading that partially agree with many research findings, but their beliefs are fragmented and particularly sketchy in regard to the cognitive and metacognitive skills required by readers to learn from science texts. The findings for attitude, belief, and total scales were substantiated by further questions in the Science and Reading Questionnaire regarding classroom practice and by individual interviews and classroom observations of a 15-teacher subsample of the questionnaire respondents.

Science deserves to be judged by its contents, not by its wrapping: Revisiting Seglen's work on journal impact and research evaluation.

Science.gov (United States)

Zhang, Lin; Rousseau, Ronald; Sivertsen, Gunnar

2017-01-01

The scientific foundation for the criticism on the use of the Journal Impact Factor (JIF) in evaluations of individual researchers and their publications was laid between 1989 and 1997 in a series of articles by Per O. Seglen. His basic work has since influenced initiatives such as the San Francisco Declaration on Research Assessment (DORA), the Leiden Manifesto for research metrics, and The Metric Tide review on the role of metrics in research assessment and management. Seglen studied the publications of only 16 senior biomedical scientists. We investigate whether Seglen's main findings still hold when using the same methods for a much larger group of Norwegian biomedical scientists with more than 18,000 publications. Our results support and add new insights to Seglen's basic work.

The induction of thyroid-gland tumours by ionizing radiation

International Nuclear Information System (INIS)

Daal, W.A.J. van.

1981-01-01

The study reported in this thesis formed part of an investigation on radiation-induced tumours in a sample of the patients given radiation therapy in the head and neck region for benign diseases at the Leiden University Hospital between 1932 and 1963. To find out whether it would be useful to trace and examine all patients, a random sample comprising 25% of the irradiated cohort was examined for (induced) tumours of the skin, mouth and throat, and the thyroid and parathyroid glands. The present study was confined to induced tumours of the thyroid gland. The literature is reviewed and analysed and the study described. With respect to the scientific aspects, it may be concluded that if the duration of followup is not taken into account, the prevalence of thyroid gland nodules and non-occult carcinomas in the surviving Leiden patients is roughly the same as that found in comparable studies done elsewhere, but for equivalent follow-up periods the incidence of both nodules and carcinomas is much lower for Leiden. (Auth.)

Through measurement to knowledge the selected papers of Heike Kamerlingh onnes 1853–1926

CERN Document Server

Goudaroulis, Yorgos

1991-01-01

"Tile; D'apC:Tile; l. DpWTa ()coi 7rpo7rapod)w £ D'T}K,mi'. "between us and Goodness the gods have placed the sweat of our brows". This quote from Isiodos, the first lyrical poet, is jotted on a sheet of paper found among the papers of Heike Kamerlingh Onnes at the Boerhaave Museum, Leiden. On this same sheet, one can also read quotes from Schiller, Goethe, Shakespeare, Homer, Pindar and Dante. Each quote is for somebody or something. It appears to have been a game played at least by Ehrenfest and Crommelin -an unmistakable sign of these two physicists's deep culture. This particular quote was for the "Werkplaats", the Physical Laboratory of the University of Leiden. Our purpose in putting together the Selected Papers of its first Director, Kamerlingh Onnes (1853-1926), is to try and articulate the dominant trends of a different type of culture at Leiden: its physics culture during the years that established low temperature physics as a distinct branch of physics. Our aims in choosing the particular papers a...

Spin gymnastics at HERA

Energy Technology Data Exchange (ETDEWEB)

Barber, Desmond; Gianfelice-Wendt, Eliana [DESY Laboratory (Germany); Berglund, Mari [DelftChemTech (Netherlands)

2003-07-01

The HERA machine at the DESY laboratory in Hamburg is unique among particle accelerators. This is because it collides electrons (or positrons) with protons at high energies. This allows physicists to study the structure of the proton at very short length scales. And when the accelerator starts running again this month, after an 18-week shutdown, it will be able to explore the proton in even greater detail thanks to a new-found ability to study these high-energy collisions using longitudinally polarized positrons. In the July issue of Physics World Desmond Barber and Eliana Gianfelice-Wendt from the DESY laboratory in Germany and Mari Berglund from DelftChemTech in the Netherlands explain the advances in accelerator science and technology that have made this possible. (U.K.)

77 FR 55863 - NASA Advisory Council; Science Committee; Earth Science Subcommittee; Applied Sciences Advisory...

Science.gov (United States)

2012-09-11

... Committee; Earth Science Subcommittee; Applied Sciences Advisory Group Meeting AGENCY: National Aeronautics... the Applied Science Advisory Group. This Subcommittee reports to the Earth Science Subcommittee... following topics: --Applied Sciences Program Update --Earth Science Data Latency Study Preliminary Update...

Interfacial and Surface Science | Materials Science | NREL

Science.gov (United States)

Science group within the Material Science Center. He oversees research studies of surfaces and interfaces Interfacial and Surface Science Interfacial and Surface Science Image of irregular-outlined, light address a broad range of fundamental and applied issues in surface and interfacial science that are

De symboliek van het snuffelen. Hoe een luchtverontreinigingsmonitor uitgroeide tot nationaal symbool

Directory of Open Access Journals (Sweden)

Ad Maas

2014-08-01

Full Text Available Recently, the Dutch national museum for the history of science and medicine, Museum Boerhaave in Leiden, acquired four air pollution monitors for its collection. These instruments were part of the Dutch national network for the measurement of air pollution, established in the 1970s. The monitors mark the transition in analytical chemistry from traditional wet-chemical techniques to the use of electronic and automatic tools. The significance of these instruments is not only scientific: they also played a social role. In the 1970s and 1980s, these air pollution monitors (popularly known as snuffelpalen (‘sniffer poles’ became a symbol for environmental worries and distrust with the political establishment, a trend we now consider as typical of that era.

Energy conservation in the existing Dutch private housing stock; Energiebesparing bestaande koopwoningen

Energy Technology Data Exchange (ETDEWEB)

Rooijers, F.J.; Leguijt, C.

2013-07-15

One of the elements of the 'SER energy agreement' concluded by the Netherlands Social and Economic Council (SER) is concerned with energy efficiency in the current private housing stock. Over the past few decades there have been many programmes in this area, and a number of measures have certainly been implemented. To say that these have been overwhelmingly successful in securing the Dutch government's climate policy targets for the built environment would be an exaggeration, though. The pace of change has been too slow. The Netherlands Society for Nature and Environment (Natuur en Milieu) asked CE Delft to estimate the impact of a package of measures for improving the energy performance of existing dwellings, comprising incentives up to the year 2020 and an obligatory label C or better thereafter. The data in this brief report are derived largely from the dashboard model 'New instruments for the existing housing stock' developed by CE Delft in collaboration with ECN [Dutch] In het SER-energieakkoord speelt energiebesparing in de bestaande woningbouw een relevante rol. Vele programma's zijn de afgelopen decennia de revue gepasseerd, waarbij zeker besparingsmaatregelen zijn getroffen. Er is echter geen sprake van doorslaggevend succes dat de klimaatdoelen van de Rijksoverheid in de gebouwde omgeving daadwerkelijk binnen bereik brengt. Meer tempo is nodig. Natuur en Milieu heeft CE Delft gevraagd om de effecten in beeld te brengen van een pakket voor de verbetering van de energiekwaliteit van bestaande woningen dat bestaat uit verleiden tot 2020, met na 2020 een verplichting tot label C of beter. De cijfers in deze notitie zijn in belangrijke mate ontleend aan het dashboardmodel 'Nieuwe instrumenten voor de bestaande bouw' van CE Delft dat is ontwikkeld in samenwerking met ECN.

Science Programs

Science.gov (United States)

Laboratory Delivering science and technology to protect our nation and promote world stability Science & ; Innovation Collaboration Careers Community Environment Science & Innovation Facilities Science Pillars Research Library Science Briefs Science News Science Highlights Lab Organizations Science Programs Applied

Science Olympiad students' nature of science understandings

Science.gov (United States)

Philpot, Cindy J.

2007-12-01

Recent reform efforts in science education focus on scientific literacy for all citizens. In order to be scientifically literate, an individual must have informed understandings of nature of science (NOS), scientific inquiry, and science content matter. This study specifically focused on Science Olympiad students' understanding of NOS as one piece of scientific literacy. Research consistently shows that science students do not have informed understandings of NOS (Abd-El-Khalick, 2002; Bell, Blair, Crawford, and Lederman, 2002; Kilcrease and Lucy, 2002; Schwartz, Lederman, and Thompson, 2001). However, McGhee-Brown, Martin, Monsaas and Stombler (2003) found that Science Olympiad students had in-depth understandings of science concepts, principles, processes, and techniques. Science Olympiad teams compete nationally and are found in rural, urban, and suburban schools. In an effort to learn from students who are generally considered high achieving students and who enjoy science, as opposed to the typical science student, the purpose of this study was to investigate Science Olympiad students' understandings of NOS and the experiences that formed their understandings. An interpretive, qualitative, case study method was used to address the research questions. The participants were purposefully and conveniently selected from the Science Olympiad team at a suburban high school. Data collection consisted of the Views of Nature of Science -- High School Questionnaire (VNOS-HS) (Schwartz, Lederman, & Thompson, 2001), semi-structured individual interviews, and a focus group. The main findings of this study were similar to much of the previous research in that the participants had informed understandings of the tentative nature of science and the role of inferences in science, but they did not have informed understandings of the role of human imagination and creativity, the empirical nature of science, or theories and laws. High level science classes and participation in

Applications of Nuclear Science for Stewardship Science

International Nuclear Information System (INIS)

Cizewski, Jolie A

2013-01-01

Stewardship science is research important to national security interests that include stockpile stewardship science, homeland security, nuclear forensics, and non-proliferation. To help address challenges in stewardship science and workforce development, the Stewardship Science Academic Alliances (SSAA) was inaugurated ten years ago by the National Nuclear Security Administration of the U. S. Department of Energy. The goal was to enhance connections between NNSA laboratories and the activities of university scientists and their students in research areas important to NNSA, including low-energy nuclear science. This paper presents an overview of recent research in low-energy nuclear science supported by the Stewardship Science Academic Alliances and the applications of this research to stewardship science.

Fascinating! Popular Science Communication and Literary Science Fiction

DEFF Research Database (Denmark)

Meyer, Gitte

2017-01-01

Some see literary Science Fiction as a possible vehicle for critical discussions about the future development and the ethical implications of science-based technologies. According to that understanding, literary Science Fiction constitutes a variety of science communication. Along related lines, ......, popular science communication with science fiction features might be expected to serve a similar purpose. Only, it is far from obvious that it actually works that way.......Some see literary Science Fiction as a possible vehicle for critical discussions about the future development and the ethical implications of science-based technologies. According to that understanding, literary Science Fiction constitutes a variety of science communication. Along related lines...

Exploring science through science fiction

CERN Document Server

Luokkala, Barry B

2014-01-01

How does Einstein’s description of space and time compare with Dr. Who? Can James Bond really escape from an armor-plated railroad car by cutting through the floor with a laser concealed in a wristwatch? What would it take to create a fully-intelligent android, such as Star Trek’s Commander Data? How might we discover intelligent civilizations on other planets in the galaxy? Is human teleportation possible? Will our technological society ever reach the point at which it becomes lawful to discriminate on the basis of genetic information, as in the movie GATTACA? Exploring Science Through Science Fiction addresses these and other interesting questions, using science fiction as a springboard for discussing fundamental science concepts and cutting-edge science research. The book is designed as a primary text for a college-level course which should appeal to students in the fine arts and humanities as well as to science and engineering students. It includes references to original research papers, landmark scie...

Book Reviews

Directory of Open Access Journals (Sweden)

Niels Mulder

1997-04-01

Full Text Available - Peter Boomgaard, Robert L. Winzeler, Latah in Southeast Asia; The history and ethnography of a culture-bound syndrome. Cambridge: Cambridge University Press, 1995, xvi + 172 pp. [Publications of the Society for Psychological Anthropology 7.] - Ad Borsboom, H.C. Coombs, Aboriginal autonomy; Issues and strategies. Cambridge: Cambridge University Press, 1995, xvi + 251 pp. - Ad Borsboom, Daniel de Coppet, Cosmos and society in Oceania. Oxford: Berg, 1995, 416 pp. [Explorations in Anthropology Series]., André Iteanu (eds. - Raymond L. Bryant, P. Boomgaard, Forests and forestry 1823-1941. Amsterdam: Royal Tropical Institute, 184 pp. [Changing Economy in Indonesia vol. 16]., R. de Bakker (eds. - David Henley, Jan M. Pluvier, Historical atlas of South-east Asia. Leiden/New York/Köln: Brill, 1995, 83 + 64 pp. [Handbuch der Orientalistik, Dritter Abteilung (Südostasien, Achter Band]. - Victor T. King, Nico Schulte Nordholt, Social science in Southeast Asia; From particularism to universalism. Amsterdam: VU University Press (for the Centre for Asian Studies Amsterdam, 1995, 165 pp. [Comparative Asian Studies 17]., Leontine Visser (eds. - Han Knapen, Bernard Sellato, Nomads of the Borneo rainforest; The economics, politics, and ideology of settling down. Translated by Stephanie Morgan. Honolulu: University of Hawaii Press, 1994, xxiii + 280 pp. - R.Z. Leirissa, David E.F. Henley, Nationalism and regionalism in a colonial context; Minahasa in the Dutch East Indies. Leiden: KITLV Press, 1996, xii + 186 pp. [Verhandelingen 168]. - K. Loven, Kees Epskamp, On printed matter and beyond; Media, orality and literacy. The Hague: Centre for the Study of Education in Developing Countries (CESO, 1995, 136 pp. [CESO Paperback 23]. - Niels Mulder, Andrée Feillard, Islam et armée dans l’Indonésie contemporaine; Les pionniers de la tradition, Paris: Éditions l’Harmattan, 1995, 379 pp. [Association Archipel, Cahier d’Archipel 28]. - Tessel Pollmann, Cees

Science Song Project: Integration of Science, Technology and Music to Learn Science and Process Skills

Directory of Open Access Journals (Sweden)

Jiyoon Yoon

2017-07-01

Full Text Available It has been critical to find a way for teachers to motivate their young children to learn science and improve science achievement. Since music has been used as a tool for educating young students, this study introduces the science song project to teacher candidates that contains science facts, concepts, laws and theories, and combines them with music for motivating their young children to learn science and improve science achievement. The purpose of the study is to determine the effect of the science song project on teacher candidates’ understanding of science processing skills and their attitudes toward science. The participants were 45 science teacher candidates who were enrolled in an EC-6 (Early Childhood through Grade 6 program in the teacher certification program at a racially diverse Texas public research university. To collect data, this study used two instruments: pre-and post-self efficacy tests before and after the science teacher candidates experienced the science song project and final reflective essay at the end of the semester. The results show that while developing their songs, the participating teacher candidates experienced a process for science practice, understood science concepts and facts, and positively improved attitudes toward science. This study suggests that the science song project is a science instruction offering rich experiences of process-based learning and positive attitudes toward science.

The Double Helix: Why Science Needs Science Fiction.

Science.gov (United States)

Andreadis, Athena

2003-01-01

Discusses why science needs science fiction, commenting on the author's book about science that draws heavily on the "Star Trek" series. The best science, in spite of popular thinking, comes from leaps of intuition, and science fiction provides a creative spark that encourages participation in science. (SLD)

Modelling and Forecasting of Rice Yield in support of Crop Insurance

Science.gov (United States)

Weerts, A.; van Verseveld, W.; Trambauer, P.; de Vries, S.; Conijn, S.; van Valkengoed, E.; Hoekman, D.; Hengsdijk, H.; Schrevel, A.

2016-12-01

The Government of Indonesia has embarked on a policy to bring crop insurance to all of Indonesia's farmers. To support the Indonesian government, the G4INDO project (www.g4indo.org) is developing/constructing an integrated platform for judging and handling insurance claims. The platform consists of bringing together remote sensed data (both visible and radar) and hydrologic and crop modelling and forecasting to improve predictions in one forecasting platform (i.e. Delft-FEWS, Werner et al., 2013). The hydrological model and crop model (LINTUL) are coupled on time stepping basis in the OpenStreams framework (see https://github.com/openstreams/wflow) and deployed in a Delft-FEWS forecasting platform to support seasonal forecasting of water availability and crop yield. First we will show the general idea about the project, the integrated platform (including Sentinel 1 & 2 data) followed by first (reforecast) results of the coupled models for predicting water availability and crop yield in the Brantas catchment in Java, Indonesia. Werner, M., Schellekens, J., Gijsbers, P., Van Dijk, M., Van den Akker, O. and Heynert K, 2013. The Delft-FEWS flow forecasting system, Environmental Modelling & Software; 40:65-77. DOI: 10.1016/j.envsoft.2012.07.010 .

Science Teaching in Science Education

Science.gov (United States)

Callahan, Brendan E.; Dopico, Eduardo

2016-01-01

Reading the interesting article "Discerning selective traditions in science education" by Per Sund, which is published in this issue of "CSSE," allows us to open the discussion on procedures for teaching science today. Clearly there is overlap between the teaching of science and other areas of knowledge. However, we must…

How to Motivate Science Teachers to Use Science Experiments

Directory of Open Access Journals (Sweden)

Josef Trna

2012-10-01

Full Text Available A science experiment is the core tool in science education. This study describes the science teachers' professional competence to implement science experiments in teaching/learning science. The main objective is the motivation of science teachers to use science experiments. The presented research tries to answer questions aimed at the science teachers' skills to use science experiments in teaching/learning science. The research discovered the following facts: science teachers do not include science experiments in teaching/learning in a suitable way; are not able to choose science experiments corresponding to the teaching phase; prefer teachers' demonstration of science experiments; are not able to improvise with the aids; use only a few experiments. The important research result is that an important motivational tool for science teachers is the creation of simple experiments. Examples of motivational simple experiments used into teachers' training for increasing their own creativity and motivation are presented.

Management of science policy, sociology of science policy and economics of science policy

CERN Document Server

Ruivo, Beatriz

2017-01-01

'Management of science policy, sociology of science policy and economics of science policy' is a theoretical essay on the scientific foundation of science policy (formulation, implementation, instruments and procedures). It can be also used as a textbook.

Is normal science good science?

Directory of Open Access Journals (Sweden)

Adrianna Kępińska

2015-09-01

Full Text Available “Normal science” is a concept introduced by Thomas Kuhn in The Structure of Scientific Revolutions (1962. In Kuhn’s view, normal science means “puzzle solving”, solving problems within the paradigm—framework most successful in solving current major scientific problems—rather than producing major novelties. This paper examines Kuhnian and Popperian accounts of normal science and their criticisms to assess if normal science is good. The advantage of normal science according to Kuhn was “psychological”: subjective satisfaction from successful “puzzle solving”. Popper argues for an “intellectual” science, one that consistently refutes conjectures (hypotheses and offers new ideas rather than focus on personal advantages. His account is criticized as too impersonal and idealistic. Feyerabend’s perspective seems more balanced; he argues for a community that would introduce new ideas, defend old ones, and enable scientists to develop in line with their subjective preferences. The paper concludes that normal science has no one clear-cut set of criteria encompassing its meaning and enabling clear assessment.

‘God is groot en wij begrijpen Hem niet’: Kaisers populaire sterrenkunde en het einde van de fysiko-theologie

Directory of Open Access Journals (Sweden)

Frans van Lunteren

2011-06-01

Full Text Available Frederik Kaiser, popular astronomy, and the decline of natural theologyThroughout his remarkable career the Leiden astronomer Frederik Kaiser (1808-1872 struggled to revive Dutch astronomy, which at the time was rather moribund. His efforts comprised mobilizing public support through popularization. In spite of a lack of illustrations, his popular Starry Sky (1844 proved immensely successful with the general public. This work differed in many respects from earlier Dutch popular writings, and helped to establish the new genre of popular science. Kaiser enunciated his idiosyncratic views on popularization in a lecture which he later published as a brochure. Whereas his research reflects the shift from the dilettante to the professional scientist in being focussed on precision measurement, his popular work likewise testified to the transition from natural philosophy to modern science. Charged with the task of composing a natural theological work on astronomy, the deeply religious Kaiser, wriggled his way through the text. Feeling unable to advance the usual arguments, he finally found refuge in the book of Job: 'Behold, God is great and we know him not'. Arguably, the rise of popular science and the decline of natural theology were intimately connected.

75 FR 10845 - Subcommittee on Forensic Science; Committee on Science; National Science and Technology Council

Science.gov (United States)

2010-03-09

... OFFICE OF SCIENCE AND TECHNOLOGY POLICY Subcommittee on Forensic Science; Committee on Science... participants. SUMMARY: The Subcommittee on Forensic Science of the National Science and Technology Council's... . Kenneth E. Melson, Co-Chair, Subcommittee on Forensic Science. [FR Doc. 2010-4899 Filed 3-8-10; 8:45 am...

Science in Science Fiction.

Science.gov (United States)

Allday, Jonathan

2003-01-01

Offers some suggestions as to how science fiction, especially television science fiction programs such as "Star Trek" and "Star Wars", can be drawn into physics lessons to illuminate some interesting issues. (Author/KHR)

Hollywood Science: Good for Hollywood, Bad for Science?

Science.gov (United States)

Perkowitz, Sidney

2009-03-01

Like it or not, most science depicted in feature films is in the form of science fiction. This isn't likely to change any time soon, if only because science fiction films are huge moneymakers for Hollywood. But beyond that, these films are a powerful cultural force. They reach millions as they depict scientific ideas from DNA and cloning to space science, whether correctly or incorrectly; reflect contemporary issues of science and society like climate change, nuclear power and biowarfare; inspire young people to become scientists; and provide defining images -- or stereotypes -- of scientists for the majority of people who've never met a real one. Certainly, most scientists feel that screen depictions of science and scientists are badly distorted. Many are, but not always. In this talk, based on my book Hollywood Science [1], I'll show examples of good and bad screen treatments of science, scientists, and their impact on society. I'll also discuss efforts to improve how science is treated in film and ways to use even bad movie science to convey real science. [4pt] [1] Sidney Perkowitz, Hollywood Science: Movies, Science, and the End of the World (Columbia University Press, New York, 2007). ISBN: 978-0231142809

Communicating Science

Science.gov (United States)

Russell, Nicholas

2009-10-01

Introduction: what this book is about and why you might want to read it; Prologue: three orphans share a common paternity: professional science communication, popular journalism, and literary fiction are not as separate as they seem; Part I. Professional Science Communication: 1. Spreading the word: the endless struggle to publish professional science; 2. Walk like an Egyptian: the alien feeling of professional science writing; 3. The future's bright? Professional science communication in the age of the internet; 4. Counting the horse's teeth: professional standards in science's barter economy; 5. Separating the wheat from the chaff: peer review on trial; Part II. Science for the Public: What Science Do People Need and How Might They Get It?: 6. The Public Understanding of Science (PUS) movement and its problems; 7. Public engagement with science and technology (PEST): fine principle, difficult practice; 8. Citizen scientists? Democratic input into science policy; 9. Teaching and learning science in schools: implications for popular science communication; Part III. Popular Science Communication: The Press and Broadcasting: 10. What every scientist should know about mass media; 11. What every scientist should know about journalists; 12. The influence of new media; 13. How the media represents science; 14. How should science journalists behave?; Part IV. The Origins of Science in Cultural Context: Five Historic Dramas: 15. A terrible storm in Wittenberg: natural knowledge through sorcery and evil; 16. A terrible storm in the Mediterranean: controlling nature with white magic and religion; 17. Thieving magpies: the subtle art of false projecting; 18. Foolish virtuosi: natural philosophy emerges as a distinct discipline but many cannot take it seriously; 19. Is scientific knowledge 'true' or should it just be 'truthfully' deployed?; Part V. Science in Literature: 20. Science and the Gothic: the three big nineteenth-century monster stories; 21. Science fiction: serious

Does science education need the history of science?

Science.gov (United States)

Gooday, Graeme; Lynch, John M; Wilson, Kenneth G; Barsky, Constance K

2008-06-01

This essay argues that science education can gain from close engagement with the history of science both in the training of prospective vocational scientists and in educating the broader public about the nature of science. First it shows how historicizing science in the classroom can improve the pedagogical experience of science students and might even help them turn into more effective professional practitioners of science. Then it examines how historians of science can support the scientific education of the general public at a time when debates over "intelligent design" are raising major questions over the kind of science that ought to be available to children in their school curricula. It concludes by considering further work that might be undertaken to show how history of science could be of more general educational interest and utility, well beyond the closed academic domains in which historians of science typically operate.

Communicating knowledge in science, science journalism and art

DEFF Research Database (Denmark)

Nielsen, Kristian Hvidtfelt

Richter. The specialized knowledge about the image is communicated in three very different contexts with three very different outcomes. The paper uses Niklas Luhmann's system theory to describe science, science journalism, and art as autonomous social subsystems of communication. Also, Luhmann's notions...... of irritation and interference are employed to frame an interpretation of the complex relations between communicating knowledge about the image in science, science journalism, and art. Even though the functional differentiation between the communication systems of science, science journalism, and art remains...... that Richter's Erster Blick ends up questioning the epistemological and ontological grounds for communication of knowledge in science and in science journalism....

Learning about Factor V Leiden Thrombophilia

Science.gov (United States)

... Care Genomic Medicine Working Group New Horizons and Research Patient Management Policy and Ethics Issues Quick Links for Patient Care Education All About the Human Genome Project Fact Sheets Genetic Education Resources for ...

Liebe ohne Leiden? Love without Sorrows?

Directory of Open Access Journals (Sweden)

Stefan Müller

2008-11-01

Full Text Available Im vorliegenden Sammelband werden unterschiedliche Zugänge und Herangehensweisen zum Thema ‚Liebe im Kapitalismus‘ nebeneinandergestellt. Die Idee der Liebe innerhalb der ‚Logik des Kapitalismus‘ soll genauer untersucht werden. Dafür werden Erfahrungen und Reflexionen aus Kunst, Literatur, Philosophie und Psychoanalyse sowie aus Datenerhebungen und Interviews herangezogen und analysiert. Die Beiträge gruppieren sich zumeist allerdings stärker um das Themenfeld der Liebe. Veränderungen der kapitalistischen Logik nachzuzeichnen, wird in den Ausführungen kaum angestrebt.The volume at hand compares varying approaches to the theme of ‘love under capitalism.’ The intention is to more closely examine the idea of love within the ‘logic of capitalism.’ In order to achieve this, experiences and reflections from art, literature, philosophy, and psychoanalysis as well as data collections and interviews are drawn out and analyzed. The contributions, however, are mostly grouped around the thematic of love. Most of the studies barely begin to sketch the changes of capitalist logic.

Review Article

African Journals Online (AJOL)

2012-12-29

Dec 29, 2012 ... Department of Electrical Engineering, Faculty of Electrical ... proposes several architectures for implementing a rasterizor unit on smart-display, ... Embedded systems ..... Master's thesis, Delft University of Technology.

Science or Science Fiction?

DEFF Research Database (Denmark)

Lefsrud, Lianne M.; Meyer, Renate

2012-01-01

This paper examines the framings and identity work associated with professionals’ discursive construction of climate change science, their legitimation of themselves as experts on ‘the truth’, and their attitudes towards regulatory measures. Drawing from survey responses of 1077 professional......, legitimation strategies, and use of emotionality and metaphor. By linking notions of the science or science fiction of climate change to the assessment of the adequacy of global and local policies and of potential organizational responses, we contribute to the understanding of ‘defensive institutional work...

Computational Materials Science | Materials Science | NREL

Science.gov (United States)

Computational Materials Science Computational Materials Science An image of interconnecting, sphere science capabilities span many research fields and interests. Electronic, Optical, and Transport Properties of Photovoltaic Materials Material properties and defect physics of Si, CdTe, III-V, CIGS, CZTS

Science deserves to be judged by its contents, not by its wrapping: Revisiting Seglen's work on journal impact and research evaluation.

Directory of Open Access Journals (Sweden)

Lin Zhang

Full Text Available The scientific foundation for the criticism on the use of the Journal Impact Factor (JIF in evaluations of individual researchers and their publications was laid between 1989 and 1997 in a series of articles by Per O. Seglen. His basic work has since influenced initiatives such as the San Francisco Declaration on Research Assessment (DORA, the Leiden Manifesto for research metrics, and The Metric Tide review on the role of metrics in research assessment and management. Seglen studied the publications of only 16 senior biomedical scientists. We investigate whether Seglen's main findings still hold when using the same methods for a much larger group of Norwegian biomedical scientists with more than 18,000 publications. Our results support and add new insights to Seglen's basic work.

Recruiting Science Majors into Secondary Science Teaching: Paid Internships in Informal Science Settings

Science.gov (United States)

Worsham, Heather M.; Friedrichsen, Patricia; Soucie, Marilyn; Barnett, Ellen; Akiba, Motoko

2014-01-01

Despite the importance of recruiting highly qualified individuals into the science teaching profession, little is known about the effectiveness of particular recruitment strategies. Over 3 years, 34 college science majors and undecided students were recruited into paid internships in informal science settings to consider secondary science teaching…

Cognitive science contributions to decision science.

Science.gov (United States)

Busemeyer, Jerome R

2015-02-01

This article briefly reviews the history and interplay between decision theory, behavioral decision-making research, and cognitive psychology. The review reveals the increasingly important impact that psychology and cognitive science have on decision science. One of the main contributions of cognitive science to decision science is the development of dynamic models that describe the cognitive processes that underlay the evolution of preferences during deliberation phase of making a decision. Copyright © 2014 Elsevier B.V. All rights reserved.

The sciences of science communication.

Science.gov (United States)

Fischhoff, Baruch

2013-08-20

The May 2012 Sackler Colloquium on "The Science of Science Communication" brought together scientists with research to communicate and scientists whose research could facilitate that communication. The latter include decision scientists who can identify the scientific results that an audience needs to know, from among all of the scientific results that it would be nice to know; behavioral scientists who can design ways to convey those results and then evaluate the success of those attempts; and social scientists who can create the channels needed for trustworthy communications. This overview offers an introduction to these communication sciences and their roles in science-based communication programs.

75 FR 4882 - Subcommittee on Forensic Science; Committee on Science; National Science and Technology Council

Science.gov (United States)

2010-01-29

... OFFICE OF SCIENCE AND TECHNOLOGY POLICY Subcommittee on Forensic Science; Committee on Science; National Science and Technology Council ACTION: Notice of Panel Session. Public input is requested concerning appropriate Federal Executive Branch responses to the National Academy of Sciences 2009 report...

Constructing a philosophy of science of cognitive science.

Science.gov (United States)

Bechtel, William

2009-07-01

Philosophy of science is positioned to make distinctive contributions to cognitive science by providing perspective on its conceptual foundations and by advancing normative recommendations. The philosophy of science I embrace is naturalistic in that it is grounded in the study of actual science. Focusing on explanation, I describe the recent development of a mechanistic philosophy of science from which I draw three normative consequences for cognitive science. First, insofar as cognitive mechanisms are information-processing mechanisms, cognitive science needs an account of how the representations invoked in cognitive mechanisms carry information about contents, and I suggest that control theory offers the needed perspective on the relation of representations to contents. Second, I argue that cognitive science requires, but is still in search of, a catalog of cognitive operations that researchers can draw upon in explaining cognitive mechanisms. Last, I provide a new perspective on the relation of cognitive science to brain sciences, one which embraces both reductive research on neural components that figure in cognitive mechanisms and a concern with recomposing higher-level mechanisms from their components and situating them in their environments. Copyright © 2009 Cognitive Science Society, Inc.

1st Hands-on Science Science Fair

OpenAIRE

Costa, Manuel F. M.; Esteves. Z.

2017-01-01

In school learning of science through investigative hands-on experiments is in the core of the Hands-on Science Network vision. However informal and non-formal contexts may also provide valuable paths for implementing this strategy aiming a better e!ective science education. In May 2011, a "rst country wide “Hands-on Science’ Science Fair” was organized in Portugal with the participation of 131 students that presented 38 projects in all "elds of Science. In this communication we will pr...

Informal science education at Science City

Science.gov (United States)

French, April Nicole

The presentation of chemistry within informal learning environments, specifically science museums and science centers is very sparse. This work examines learning in Kansas City's Science City's Astronaut Training Center in order to identify specific behaviors associated with visitors' perception of learning and their attitudes toward space and science to develop an effective chemistry exhibit. Grounded in social-constructivism and the Contextual Model of Learning, this work approaches learning in informal environments as resulting from social interactions constructed over time from interaction between visitors. Visitors to the Astronaut Training Center were surveyed both during their visit and a year after the visit to establish their perceptions of behavior within the exhibit and attitudes toward space and science. Observations of visitor behavior and a survey of the Science City staff were used to corroborate visitor responses. Eighty-six percent of visitors to Science City indicated they had learned from their experiences in the Astronaut Training Center. No correlation was found between this perception of learning and visitor's interactions with exhibit stations. Visitor attitudes were generally positive toward learning in informal settings and space science as it was presented in the exhibit. Visitors also felt positively toward using video game technology as learning tools. This opens opportunities to developing chemistry exhibits using video technology to lessen the waste stream produced by a full scale chemistry exhibit.

76 FR 6163 - Subcommittee on Forensic Science; Committee on Science; National Science and Technology Council

Science.gov (United States)

2011-02-03

... Branch responses to the AFIS interoperability issues identified in the National Academy of Sciences 2009... OFFICE OF SCIENCE AND TECHNOLOGY POLICY Subcommittee on Forensic Science; Committee on Science; National Science and Technology Council ACTION: Notice of meeting. Public input is requested concerning...

The Science of Science Communication and Protecting the Science Communication Environment

Science.gov (United States)

Kahan, D.

2012-12-01

Promoting public comprehension of science is only one aim of the science of science communication and is likely not the most important one for the well-being of a democratic society. Ordinary citizens form quadrillions of correct beliefs on matters that turn on complicated scientific principles they cannot even identify much less understand. The reason they fail to converge on beliefs consistent with scientific evidence on certain other consequential matters—from climate change to genetically modified foods to compusory adolescent HPV vaccination—is not the failure of scientists or science communicators to speak clearly or the inability of ordinary citizens to understand what they are saying. Rather, the source of such conflict is the proliferation of antagonistic cultural meanings. When they become attached to particular facts that admit of scientific investigation, these meanings are a kind of pollution of the science communication environment that disables the faculties ordinary citizens use to reliably absorb collective knowledge from their everyday interactions. The quality of the science communication environment is thus just as critical for enlightened self-government as the quality of the natural environment is for the physical health and well-being of a society's members. Understanding how this science communication environment works, fashioning procedures to prevent it from becoming contaminated with antagonistic meanings, and formulating effective interventions to detoxify it when protective strategies fail—those are the most critical functions science communication can perform in a democratic society.

Science Smiles

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. Science Smiles. Articles in Resonance – Journal of Science Education. Volume 1 Issue 4 April 1996 pp 4-4 Science Smiles. Chief Editor's column / Science Smiles · R K Laxman · More Details Fulltext PDF. Volume 1 Issue 5 May 1996 pp 3-3 Science Smiles.

A study of science leadership and science standards in exemplary standards-based science programs

Science.gov (United States)

Carpenter, Wendy Renae

The purpose for conducting this qualitative study was to explore best practices of exemplary standards-based science programs and instructional leadership practices in a charter high school and in a traditional high school. The focus of this study included how twelve participants aligned practices to National Science Education Standards to describe their science programs and science instructional practices. This study used a multi-site case study qualitative design. Data were obtained through a review of literature, interviews, observations, review of educational documents, and researcher's notes collected in a field log. The methodology used was a multi-site case study because of the potential, through cross analysis, for providing greater explanation of the findings in the study (Merriam, 1988). This study discovered six characteristics about the two high school's science programs that enhance the literature found in the National Science Education Standards; (a) Culture of expectations for learning-In exemplary science programs teachers are familiar with a wide range of curricula. They have the ability to examine critically and select activities to use with their students to promote the understanding of science; (b) Culture of varied experiences-In exemplary science programs students are provided different paths to learning, which help students, take in information and make sense of concepts and skills that are set forth by the standards; (c) Culture of continuous feedback-In exemplary science programs teachers and students work together to engage students in ongoing assessments of their work and that of others as prescribed in the standards; (d) Culture of Observations-In exemplary science programs students, teachers, and principals reflect on classroom instructional practices; teachers receive ongoing evaluations about their teaching and apply feedback towards improving practices as outlined in the standards; (e) Culture of continuous learning-In exemplary

A Numerical Study of Hydrodynamics and Sediment Transport in Fourleague Bay, Louisiana

Science.gov (United States)

Hu, K.; Chen, Q. J.; Xu, K.; Bentley, S. J.; WANG, J.

2017-12-01

Fourleague Bay is a shallow and vertically well-mixed estuary in south-central Louisiana. This estuary is highly impacted by wind (e.g., cold fronts and tropical storms), river discharge from the Atchafalaya River and tides from the Gulf of Mexico, and is being used as an analog site to study impacts of sediment-diversion restoration strategies in the Mississippi River Delta. In this study, a coupled flow-wave Delft3D model was setup and applied to study hydrodynamics and sediment transport in this area. The model grid size is 1071x631 with a 50-m resolution in the bay. Vegetation is considered by rigid cylinders in both flow and wave modules. The offshore water level boundary conditions were provided by a Gulf-scale Delft3D model. Model parameters, especially for cohesive sediment transport such as settling velocity, erosion rate and critical bottom shear stress, were calibrated using the field observation data during three seasons from May 2015 to March 2016. The modeled water levels, currents, significant wave heights and suspended sediment concentrations agreed fairly well with measurements, which suggests a reasonable model performance. Seasonal variations were analyzed based on different scenarios. A series of numerical experiments were set up to quantify the contributions of different factors, such as river discharge, tides and waves to sediment transport in this area. This model will be further applied to be part of a landscape ecosystem model to test landscape and population change over time with manipulations to sediment delivery. This study was funded by the National Science Foundation (SEES-1427389 and CCF-1539567).

mHealth intervention to support asthma self-management in adolescents: the ADAPT study

Directory of Open Access Journals (Sweden)

Kosse RC

2017-03-01

Full Text Available Richelle C Kosse,1 Marcel L Bouvy,1 Tjalling W de Vries,2 Ad A Kaptein,3 Harm CJ Geers,1 Liset van Dijk,4 Ellen S Koster1 1Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, 2Department of Paediatrics, Medical Center Leeuwarden, Leeuwarden, 3Medical Psychology, Leiden University Medical Center, Leiden, 4NIVEL, the Netherlands Institute for Health Services Research, Utrecht, the Netherlands Purpose: Poor medication adherence in adolescents with asthma results in poorly controlled disease and increased morbidity. The aim of the ADolescent Adherence Patient Tool (ADAPT study is to develop an mHealth intervention to support self-management and to evaluate the effectiveness in improving medication adherence and asthma control. Intervention: The ADAPT intervention consists of an interactive smartphone application (app connected to a desktop application for health care providers, in this study, the community pharmacist. The app contains several functions to improve adherence as follows: 1 a questionnaire function to rate asthma symptoms and monitor these over time; 2 short movie clips with medication and disease information; 3 a medication reminder; 4 a chat function with peers; and 5 a chat function with the pharmacist. The pharmacist receives data from the patient’s app through the desktop application, which enables the pharmacist to send information and feedback to the patient. Study design: The ADAPT intervention is tested in a community pharmacy-based cluster randomized controlled trial in the Netherlands, aiming to include 352 adolescents with asthma. The main outcome is adherence, measured by patient’s self-report and refill adherence calculated from pharmacy dispensing records. In addition, asthma control, illness perceptions, medication beliefs, and asthma-related quality of life are measured. Conclusion: This study will provide in

Science for Diplomacy, Diplomacy for Science

Science.gov (United States)

Colglazier, E. Wiliam

2015-04-01

I was a strong proponent of ``science diplomacy'' when I became Science and Technology Adviser to the Secretary of State in 2011. I thought I knew a lot about the subject after being engaged for four decades on international S&T policy issues and having had distinguished scientists as mentors who spent much of their time using science as a tool for building better relations between countries and working to make the world more peaceful, prosperous, and secure. I learned a lot from my three years inside the State Department, including great appreciation and respect for the real diplomats who work to defuse conflicts and avoid wars. But I also learned a lot about science diplomacy, both using science to advance diplomacy and diplomacy to advance science. My talk will focus on the five big things that I learned, and from that the one thing where I am focusing my energies to try to make a difference now that I am a private citizen again.

The k0-IAEA program

International Nuclear Information System (INIS)

Rossbach, M.; Blaauw, M.; Bacchi, M.A.; Xilei Lin

2007-01-01

New software was developed to assist users of the k 0 -approach in NAA to harmonize their results. The k 0 -IAEA software uses the holistic approach developed at the Delft Interfaculty Reactor Institute and incorporates the latest k 0 data catalogue together with additional information on coincidence and sum peaks, which together are used in the joint evaluation of samples. Multiple irradiations as well as multiple measurements of samples are treated simultaneously. Flux parameter determination as well as efficiency calibrations of detectors are accommodated using a singlemeasurement approach as developed at the Interfaculty Reactor Institute, Delft. The standard Windows software will stimulate the application of the k 0 approach through the free distribution and updates of the program. (author)

Rigorous project for existing houses. Energy conservation requires evolution; Rigoureus project voor bestaande woningen. Evolutie voor energiebesparing nodig

Energy Technology Data Exchange (ETDEWEB)

Clocquet, R. [DHV, Amersfoort (Netherlands); Koene, F. [ECN Efficiency and Infrastructure, Petten (Netherlands)

2010-05-15

How can existing terraced houses be renovated in such a way that their energy use decreases with 75 percent? The Rigorous project of the Energy research Centre of the Netherlands (ECN), TNO, Delft University of Technology and DHV, developed innovative renovation concepts that make such savings feasible by combining constructional measures with installation concepts. On top of that it is also essential that consumer behavior is addressed. [Dutch] Hoe kunnen bestaande rijtjeswoningen zo worden gerenoveerd dat het totale energiegebruik met 75 procent afneemt? In het Rigoureus-project hebben ECN, TNO, TU Delft en DHV innovatieve renovatieconcepten ontwikkeld die dat, door een combinatie van bouwkundige maatregelen en uitgeldende installatieconcepten, mogelijk maken. Daarbij blijkt het van essentieel belang ook het gebruikersgedrag aan te pakken.

Probe into geo-information science and information science in nuclear and geography science in China

International Nuclear Information System (INIS)

Tang Bin

2001-01-01

In the past ten years a new science-Geo-Information Science, a branch of Geoscience, developed very fast, which has been valued and paid much attention to. Based on information science, the author analyzes the flow of material, energy, people and information and their relations, presents the place of Geo-Information Science in Geo-science and its content from Geo-Informatics, Geo-Information technology and the application of itself. Finally, the author discusses the main content and problem existed in Geo-Information Science involved in Nuclear and Geography Science

Frederik Kaiser (1808-1872, een gekweld man met een missie

Directory of Open Access Journals (Sweden)

Huib Zuidervaart

2011-06-01

Full Text Available Frederik Kaiser (1808-1872, a tormented man with a missionThe Leiden astronomer Kaiser has been instrumental for the rise of Dutch astronomy in the late nineteenth-century. His career was impressive. In 1826, without any formal university education, he began at the Leiden Astronomical Observatory as an ordinary observer. Through his work in astronomy he obtained an honorary doctorate, which enabled him in 1838 to become director of the observatory. In 1844 he was appointed full professor and in the academic year 1857/1858 he even became Rector Magnificus of Leiden University. In 1860 he even saw the fulfillmentof his life-long dream: the opening of a brand new astronomical observatory. However, in spite of these obvious professional successes, Kaiser's personal life was full of melancholy. This paper investigates Kaiser's personality, using correspondence with his family, as well as testimonies written down by his students and other contemporaries. Among others, we demonstrate the way in which Kaiser used his personal network, as well as his fierce continuous – and often publicly expressed – complaining, as a successful strategy in establishing his new astronomical observatory.

Archives: Afrique Science: Revue Internationale des Sciences et ...

African Journals Online (AJOL)

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Pure Science and Applied Science

Directory of Open Access Journals (Sweden)

Robert J. Aumann

2011-01-01

Full Text Available (Excerpt The name of my talk is Pure Science and Applied Science, and the idea I would like to sell to you today is that there is no such thing as “pure” or “applied” science. In other words, there is such a thing as science, but there is no difference between pure and applied science. Science is one entity and cannot be separated into different categories. In order to back that up, I would like to tell you a little story. As an undergraduate, I studied mathematics at City College in New York. At that time, what was called Pure Mathematics was in vogue, and the more prominent mathematicians were a little contemptuous of any kind of application. A very famous, prominent mathematician in the first half of the previous century by the name of G. H. Hardy, who was in a branch of mathematics called number theory, said that the only thing he regretted was that he unwittingly did some important work in mathematical genetics that eventually turned out to have some application. … Such was the atmosphere in the late ’40s of the previous century and, being a young man and impressionable, I was swept up in this atmosphere.

Prediction of RO/NF membrane rejections of PhACs and organic compounds : A statistical analysis

NARCIS (Netherlands)

Yangali-Quintanilla, V.; Kim, T.U.; Kennedy, M.; Amy, G.

2008-01-01

OA fund TU Delft Rejections of pharmaceutical compounds (Ibuprofen, Diclofenac, Clofibric acid, Naproxen, Primidone, Phenacetin) and organic compounds (Dichloroacetic acid, Trichloroacetic acid, Chloroform, Bromoform, Trichloroethene, Perchloroethene, Car-bontetrachloride, Carbontetrabromide) by NF

Second International Diagnostic Competition - DXC'10

Data.gov (United States)

National Aeronautics and Space Administration — A framework to compare and evaluate diagnosis algorithms (DAs) has been created jointly by NASA Ames Research Center, Palo Alto Research Center, and Delft University...

11th Traffic and Granular Flow Conference

CERN Document Server

Daamen, Winnie

2016-01-01

The Conference on Traffic and Granular Flow brings together international researchers from different fields ranging from physics to computer science and engineering to discuss the latest developments in traffic-related systems. Originally conceived to facilitate new ideas by considering the similarities of traffic and granular flow, TGF'15, organised by Delft University of Technology, now covers a broad range of topics related to driven particle and transport systems. Besides the classical topics of granular flow and highway traffic, its scope includes data transport (Internet traffic), pedestrian and evacuation dynamics, intercellular transport, swarm behaviour and the collective dynamics of other biological systems. Recent advances in modelling, computer simulation and phenomenology are presented, and prospects for applications, for example to traffic control, are discussed. The conference explores the interrelations between the above-mentioned fields and offers the opportunity to stimulate interdisciplinar...

Science Process Skills in Science Curricula Applied in Turkey

Science.gov (United States)

Yumusak, Güngör Keskinkiliç

2016-01-01

One of the most important objectives of the science curricula is to bring in science process skills. The science process skills are skills that lie under scientific thinking and decision-making. Thus it is important for a science curricula to be rationalized in such a way that it brings in science process skills. New science curricula were…

International production on science oriented towards data: analysis of the terms data science and e-science in scopus and the web of science

OpenAIRE

Leilah Santiago Bufrem; Fábio Mascarenhas e Silva; Natanael Vitor Sobral; Anna Elizabeth Galvão Coutinho Correia

2016-01-01

Introduction: current configuration in the dynamics of production and scientific communication reveals the role of Science Oriented Towards Data, a comprehensive conception represented, mainly, by terms such as "e-Science" and "Data Science". Objective: To present the global scientific production on Science Oriented Towards Data by using the terms "e-Science" and "Data Science" in Scopus and the Web of Science during 2006-2016. Methodology: The study is divided into five phases: a) sear...

Physical Sciences 2007 Science & Technology Highlights

Energy Technology Data Exchange (ETDEWEB)

Hazi, A U

2008-04-07

The Physical Sciences Directorate applies frontier physics and technology to grand challenges in national security. Our highly integrated and multidisciplinary research program involves collaborations throughout Lawrence Livermore National Laboratory, the National Nuclear Security Administration, the Department of Energy, and with academic and industrial partners. The Directorate has a budget of approximately $150 million, and a staff of approximately 350 employees. Our scientists provide expertise in condensed matter and high-pressure physics, plasma physics, high-energy-density science, fusion energy science and technology, nuclear and particle physics, accelerator physics, radiation detection, optical science, biotechnology, and astrophysics. This document highlights the outstanding research and development activities in the Physical Sciences Directorate that made news in 2007. It also summarizes the awards and recognition received by members of the Directorate in 2007.

How In-Service Science Teachers Integrate History and Nature of Science in Elementary Science Courses

Science.gov (United States)

Hacieminoglu, Esme

2014-01-01

The purpose of this study is to investigate how the in-service science teachers' (IST) perceptions and practices about curriculum and integration of the history of science (HOS) and the nature of science (NOS) affect their science courses. For this aim, how ISTs integrated the NOS and HOS in their elementary science courses for understanding of…

Data-driven predictions in the science of science.

Science.gov (United States)

Clauset, Aaron; Larremore, Daniel B; Sinatra, Roberta

2017-02-03

The desire to predict discoveries-to have some idea, in advance, of what will be discovered, by whom, when, and where-pervades nearly all aspects of modern science, from individual scientists to publishers, from funding agencies to hiring committees. In this Essay, we survey the emerging and interdisciplinary field of the "science of science" and what it teaches us about the predictability of scientific discovery. We then discuss future opportunities for improving predictions derived from the science of science and its potential impact, positive and negative, on the scientific community. Copyright © 2017, American Association for the Advancement of Science.

Can citizen science enhance public understanding of science?

Science.gov (United States)

Bonney, Rick; Phillips, Tina B; Ballard, Heidi L; Enck, Jody W

2016-01-01

Over the past 20 years, thousands of citizen science projects engaging millions of participants in collecting and/or processing data have sprung up around the world. Here we review documented outcomes from four categories of citizen science projects which are defined by the nature of the activities in which their participants engage - Data Collection, Data Processing, Curriculum-based, and Community Science. We find strong evidence that scientific outcomes of citizen science are well documented, particularly for Data Collection and Data Processing projects. We find limited but growing evidence that citizen science projects achieve participant gains in knowledge about science knowledge and process, increase public awareness of the diversity of scientific research, and provide deeper meaning to participants' hobbies. We also find some evidence that citizen science can contribute positively to social well-being by influencing the questions that are being addressed and by giving people a voice in local environmental decision making. While not all citizen science projects are intended to achieve a greater degree of public understanding of science, social change, or improved science -society relationships, those projects that do require effort and resources in four main categories: (1) project design, (2) outcomes measurement, (3) engagement of new audiences, and (4) new directions for research. © The Author(s) 2015.

Islam and Science

Science.gov (United States)

Salam, Abdus

The following sections are included: * The Holy Quran and Science * Modem Science, A Greco- Islamic Legacy * The Decline of Sciences in Islam * The Limitations of Science * Faith and Science * The Present Picture of Sciences in the Islamic Countries * Renaissance of Sciences in Islam * Steps Needed for Building up Sciences in the Islamic Countries * Science Education * Science Foundations in Islam * Technology in Our Countries * Concluding Remarks * REFERENCES

Changing culture - the experience of TU Delft Library

NARCIS (Netherlands)

Heijne, M.; Van der Sar, E.

2004-01-01

When seeking to introduce change into an organisation, it is usually the organisational structure that is the main focus of attention. A reorganisation, however, does not necessarily resolve underlying cultural problems. It can, in fact, be just these cultural problems that prevent the organisation

DUNBID, the Delft University neutron backscattering imaging detector

International Nuclear Information System (INIS)

Bom, V.R.; Eijk, C.W.E. van; Ali, M.A.

2005-01-01

In the search for low-metallic land mines, the neutron backscattering technique may be applied if the soil is sufficiently dry. An advantage of this method is the speed of detection: the scanning speed may be made comparable to that of a metal detector. A two-dimensional position sensitive detector is tested to obtain an image of the back scattered thermal neutron radiation. Results of experiments using a radionuclide neutron source are presented. The on-mine to no-mine signal ratio can be improved by the application of a window on the neutron time-of-flight. Results using a pulsed neutron generator are also presented

Citizen Science: Opportunities for Girls' Development of Science Identity

Science.gov (United States)

Brien, Sinead Carroll

Many students in the United States, particularly girls, have lost interest in science by the time they reach high school and do not pursue higher degrees or careers in science. Several science education researchers have found that the ways in which youth see themselves and position themselves in relation to science can influence whether they pursue science studies and careers. I suggest that participation in a citizen science program, which I define as a program in which girls interact with professional scientists and collect data that contributes to scientific research, could contribute to changing girls' perceptions of science and scientists, and promote their science identity work. I refer to science identity as self-recognition and recognition by others that one thinks scientifically and does scientific work. I examined a case study to document and analyze the relationship between girls' participation in a summer citizen science project and their development of science identity. I observed six girls between the ages of 16 and 18 during the Milkweed and Monarch Project, taking field notes on focal girls' interactions with other youth, adults, and the scientist, conducted highly-structured interviews both pre-and post- girls' program participation, and interviewed the project scientist and educator. I qualitatively analyzed field notes and interview responses for themes in girls' discussion of what it meant to think scientifically, roles they took on, and how they recognized themselves as thinking scientifically. I found that girls who saw themselves as thinking scientifically during the program seemed to demonstrate shifts in their science identity. The aspects of the citizen science program that seemed to most influence shifts in these girls' science identities were 1) the framing of the project work as "real science, 2) that it involved ecological field work, and 3) that it created a culture that valued data and scientific work. However, some of the girls only

Identifying Relevant Anti-Science Perceptions to Improve Science-Based Communication: The Negative Perceptions of Science Scale

Directory of Open Access Journals (Sweden)

Melanie Morgan

2018-04-01

Full Text Available Science communicators and scholars have struggled to understand what appears to be increasingly frequent endorsement of a wide range of anti-science beliefs and a corresponding reduction of trust in science. A common explanation for this issue is a lack of science literacy/knowledge among the general public (Funk et al. 2015. However, other possible explanations have been advanced, including conflict with alternative belief systems and other contextual factors, and even cultural factors (Gauchat 2008; Kahan 2015 that are not necessarily due to knowledge deficits. One of the challenges is that there are limited tools available to measure a range of possible underlying negative perceptions of science that could provide a more nuanced framework within which to improve communication around important scientific topics. This project describes two studies detailing the development and validation of the Negative Perceptions of Science Scale (NPSS, a multi-dimensional instrument that taps into several distinct sets of negative science perceptions: Science as Corrupt, Science as Complex, Science as Heretical, and Science as Limited. Evidence for the reliability and validity of the NPSS is described. The sub-dimensions of the NPSS are associated with a range of specific anti-science beliefs across a broad set of topic areas above and beyond that explained by demographics (including education, sex, age, and income, political, and religious ideology. Implications for these findings for improving science communication and science-related message tailoring are discussed.

Young "Science Ambassadors" Raise the Profile of Science

Science.gov (United States)

Ridley, Katie

2014-01-01

Katie Ridley, science coordinator at St. Gregory's Catholic Primary School, Liverpool, UK, states that the inspiration for "science ambassadors" came after embarking on the Primary Science Quality Mark programme at their school. Ridley realized that science was just not recognised as such by the children, they talked about scientific…

Science teacher orientations and PCK across science topics in grade 9 earth science

Science.gov (United States)

Campbell, Todd; Melville, Wayne; Goodwin, Dawne

2017-07-01

While the literature is replete with studies examining teacher knowledge and pedagogical content knowledge (PCK), few studies have investigated how science teacher orientations (STOs) shape classroom instruction. Therefore, this research explores the interplay between a STOs and the topic specificity of PCK across two science topics within a grade 9 earth science course. Through interviews and observations of one teacher's classroom across two sequentially taught, this research contests the notion that teachers hold a single way of conceptualising science teaching and learning. In this, we consider if multiple ontologies can provide potential explanatory power for characterising instructional enactments. In earlier work with the teacher in this study, using generic interview prompts and general discussions about science teaching and learning, we accepted the existence of a unitary STO and its promise of consistent reformed instruction in the classroom. However, upon close examination of instruction focused on different science topics, evidence was found to demonstrate the explanatory power of multiple ontologies for shaping characteristically different epistemological constructions across science topics. This research points to the need for care in generalising about teacher practice, as it reveals that a teacher's practice, and orientation, can vary, dependent on the context and science topics taught.

Capabilities: Science Pillars

Science.gov (United States)

Alamos National Laboratory Delivering science and technology to protect our nation and promote world stability Science & Innovation Collaboration Careers Community Environment Science & Innovation Facilities Science Pillars Research Library Science Briefs Science News Science Highlights Lab Organizations

Faces of Science

Science.gov (United States)

Alamos National Laboratory Delivering science and technology to protect our nation and promote world stability Science & Innovation Collaboration Careers Community Environment Science & Innovation Facilities Science Pillars Research Library Science Briefs Science News Science Highlights Lab Organizations

Bradbury Science Museum

Science.gov (United States)

Alamos National Laboratory Delivering science and technology to protect our nation and promote world stability Science & Innovation Collaboration Careers Community Environment Science & Innovation Facilities Science Pillars Research Library Science Briefs Science News Science Highlights Lab Organizations

Office of Science

Science.gov (United States)

Alamos National Laboratory Delivering science and technology to protect our nation and promote world stability Science & Innovation Collaboration Careers Community Environment Science & Innovation Facilities Science Pillars Research Library Science Briefs Science News Science Highlights Lab Organizations

Romanticism and Romantic Science: Their Contribution to Science Education

Science.gov (United States)

Hadzigeorgiou, Yannis; Schulz, Roland

2014-01-01

The unique contributions of romanticism and romantic science have been generally ignored or undervalued in history and philosophy of science studies and science education. Although more recent research in history of science has come to delineate the value of both topics for the development of modern science, their merit for the educational field…

Adapting Practices of Science Journalism to Foster Science Literacy

Science.gov (United States)

Polman, Joseph L.; Newman, Alan; Saul, Ellen Wendy; Farrar, Cathy

2014-01-01

In this paper, the authors describe how the practices of expert science journalists enable them to act as "competent outsiders" to science. We assert that selected science journalism practices can be used to design reform-based science instruction; these practices not only foster science literacy that is useful in daily life, but also…

Factors Influencing Science Content Accuracy in Elementary Inquiry Science Lessons

Science.gov (United States)

Nowicki, Barbara L.; Sullivan-Watts, Barbara; Shim, Minsuk K.; Young, Betty; Pockalny, Robert

2013-06-01

Elementary teachers face increasing demands to engage children in authentic science process and argument while simultaneously preparing them with knowledge of science facts, vocabulary, and concepts. This reform is particularly challenging due to concerns that elementary teachers lack adequate science background to teach science accurately. This study examined 81 in-classroom inquiry science lessons for preservice education majors and their cooperating teachers to determine the accuracy of the science content delivered in elementary classrooms. Our results showed that 74 % of experienced teachers and 50 % of student teachers presented science lessons with greater than 90 % accuracy. Eleven of the 81 lessons (9 preservice, 2 cooperating teachers) failed to deliver accurate science content to the class. Science content accuracy was highly correlated with the use of kit-based resources supported with professional development, a preference for teaching science, and grade level. There was no correlation between the accuracy of science content and some common measures of teacher content knowledge (i.e., number of college science courses, science grades, or scores on a general science content test). Our study concluded that when provided with high quality curricular materials and targeted professional development, elementary teachers learn needed science content and present it accurately to their students.

Book Reviews

Directory of Open Access Journals (Sweden)

Ann Kumar

1999-10-01

Linguistic Studies of Indonesian and Other Languages in Indonesia 38.] - Ch. F. van Fraassen, R.Z. Leirissa, Halmahera Timur dan Raja Jailolo; Pergolakan sekitar Laut Seram awal abad 19. Jakarta: Balai Pustaka, 1996, xiv + 256 pp. - Frances Gouda, Denys Lombard, Rêver l’Asie; Exotisme et littérature coloniale aux Indes, an Indochine et en Insulinde. Paris: Éditions de l’École des Hautes Études en Sciences Sociales, 1993, 486 pp., Catherine Champion, Henri Chambert-Loir (eds. - Hans Hägerdal, Timothy Lindsey, The romance of K’tut Tantri and Indonesia; Texts and scripts, history and identity. Kuala Lumpur: Oxford University Press, 1997, xix + 362 + 24 pp. - Renee Hagesteijn, Ina E. Slamet-Velsink, Emerging hierarchies; Processes of stratification and early state formation in the Indonesian archipelago: prehistory and the ethnographic present. Leiden: KITLV Press, 1995, ix + 279 pp. [VKI 166.] - David Henley, Victor T. King, Environmental challenges in South-East Asia. Richmond: Curzon Press, 1998, xviii + 410 pp. [Nordic Institute of Asian Studies, Man and Nature in Asia Series 2.] - C. de Jonge, Ton Otto, Cultural dynamics of religious change in Oceania. Leiden: KITLV Press, 1997, viii + 144 pp. [VKI 176.], Ad Boorsboom (eds. - C. de Jonge, Chris Sugden, Seeking the Asian face of Jesus; A critical and comparative study of the practice and theology of Christian social witness in Indonesia and India between 1974 and 1996. Oxford: Regnum, 1997, xix + 496 pp. - John N. Miksic, Roy E. Jordaan, In praise of Prambanan; Dutch essays on the Loro Jonggrang temple complex. Leiden: KITLV Press, 1996, xii + 259 pp. [Translation Series 26.] - Marije Plomp, Ann Kumar, Illuminations; The writing traditions of Indonesia; Featuring manuscripts from the National Library of Indonesia. Jakarta: The Lontar Foundation, New York: Weatherhill, 1996., John H. McGlynn (eds. - Susan de Roode, Eveline Ferretti, Cutting across the lands; An annotated bibliography on natural resource management

A Festival of Contemporary Science for Science Teachers

Science.gov (United States)

Harrison, Tim; Berry, Bryan; Shallcross, Dudley

2010-01-01

In this article, the authors describe the first Festival of Contemporary Science for Science Teachers which was held in January 2010. Focusing on a number of leading-edge science topics, this new festival was organised by Bristol ChemLabS, in collaboration with the Science Learning Centre South West, and involved academics from several departments…

Preservice Science Teachers' Views on Science-Technology-Society

Science.gov (United States)

Dikmentepe, Emel; Yakar, Zeha

2016-01-01

The aim of this study is to investigate the views of pre-service science teachers on Science-Technology-Society (STS). In the research, a descriptive research method was used and data were collected using the Views on Science-Technology-Society (VOSTS) Questionnaire. In general, the results of this study revealed that pre-service science teachers…

Democratizing data science through data science training.

Science.gov (United States)

Van Horn, John Darrell; Fierro, Lily; Kamdar, Jeana; Gordon, Jonathan; Stewart, Crystal; Bhattrai, Avnish; Abe, Sumiko; Lei, Xiaoxiao; O'Driscoll, Caroline; Sinha, Aakanchha; Jain, Priyambada; Burns, Gully; Lerman, Kristina; Ambite, José Luis

2018-01-01

The biomedical sciences have experienced an explosion of data which promises to overwhelm many current practitioners. Without easy access to data science training resources, biomedical researchers may find themselves unable to wrangle their own datasets. In 2014, to address the challenges posed such a data onslaught, the National Institutes of Health (NIH) launched the Big Data to Knowledge (BD2K) initiative. To this end, the BD2K Training Coordinating Center (TCC; bigdatau.org) was funded to facilitate both in-person and online learning, and open up the concepts of data science to the widest possible audience. Here, we describe the activities of the BD2K TCC and its focus on the construction of the Educational Resource Discovery Index (ERuDIte), which identifies, collects, describes, and organizes online data science materials from BD2K awardees, open online courses, and videos from scientific lectures and tutorials. ERuDIte now indexes over 9,500 resources. Given the richness of online training materials and the constant evolution of biomedical data science, computational methods applying information retrieval, natural language processing, and machine learning techniques are required - in effect, using data science to inform training in data science. In so doing, the TCC seeks to democratize novel insights and discoveries brought forth via large-scale data science training.

PREFACE: The Science of Making Torque from Wind 2014 (TORQUE 2014)

Science.gov (United States)

Mann, Jakob; Bak, Christian; Bechmann, Andreas; Bingöl, Ferhat; Dellwik, Ebba; Dimitrov, Nikolay; Giebel, Gregor; Hansen, Martin O. L.; Jensen, Dorte Juul; Larsen, Gunner; Aagaard Madsen, Helge; Natarajan, Anand; Rathmann, Ole; Sathe, Ameya; Nørkær Sørensen, Jens; Nørkær Sørensen, Niels

2014-06-01

The 186 papers in this volume constitute the proceedings of the fifth Science of Making Torque from Wind conference, which is organized by the European Academy of Wind Energy (EAWE, www.eawe.eu). The conference, also called Torque 2014, is held at the Technical University of Denmark (DTU) 17-20 June 2014. The EAWE conference series started in 2004 in Delft, the Netherlands. In 2007 it was held in Copenhagen, in 2010 in Heraklion, Greece, and then in 2012 in Oldenburg, Germany. The global yearly production of electrical energy by wind turbines has grown approximately by 25% annually over the last couple of decades and covers now 2-3% of the global electrical power consumption. In order to make a significant impact on one of the large challenges of our time, namely global warming, the growth has to continue for a decade or two yet. This in turn requires research and education in wind turbine aerodynamics and wind resources, the two topics which are the main subjects of this conference. Similar to the growth in electrical power production by wind is the growth in scientific papers about wind energy. Over the last decade the number of papers has also grown by about 25% annually, and many research based companies all over the world are founded. Hence, the wind energy research community is rapidly expanding and the Torque conference series offers a good opportunity to meet and exchange ideas. We hope that the Torque 2014 will heighten the quality of the wind energy research, while the participants will enjoy each others company in Copenhagen. Many people have been involved in producing the Torque 2014 proceedings. The work by more than two hundred reviewers ensuring the quality of the papers is greatly appreciated. The timely evaluation and coordination of the reviews would not have been possible without the work of sixteen ''section editors'' all from DTU Wind Energy: Christian Bak, Andreas Bechmann, Ferhat Bingöl, Ebba Dellwik, Nikolay Dimitrov, Gregor Giebel, Martin

Impact of Informal Science Education on Children's Attitudes About Science

Science.gov (United States)

Wulf, Rosemary; Mayhew, Laurel M.; Finkelstein, Noah D.

2010-10-01

The JILA Physics Frontier Center Partnerships for Informal Science Education in the Community (PISEC) provides informal afterschool inquiry-based science teaching opportunities for university participants with children typically underrepresented in science. We focus on the potential for this program to help increase children's interest in science, mathematics, and engineering and their understanding of the nature of science by validating the Children's Attitude Survey, which is based on the Colorado Learning Attitudes about Science Survey [1] and designed to measure shifts in children's attitudes about science and the nature of science. We present pre- and post-semester results for several semesters of the PISEC program, and demonstrate that, unlike most introductory physics courses in college, our after-school informal science programs support and promote positive attitudes about science.

When Nature of Science Meets Marxism: Aspects of Nature of Science Taught by Chinese Science Teacher Educators to Prospective Science Teachers

Science.gov (United States)

Wan, Zhi Hong; Wong, Siu Ling; Zhan, Ying

2013-01-01

Nature of science (NOS) is beginning to find its place in the science education in China. In a study which investigated Chinese science teacher educators' conceptions of teaching NOS to prospective science teachers through semi-structured interviews, five key dimensions emerged from the data. This paper focuses on the dimension, "NOS content…

Fort Collins Science Center-Fiscal year 2009 science accomplishments

Science.gov (United States)

Wilson, Juliette T.

2010-01-01

Public land and natural resource managers in the United States are confronted with increasingly complex decisions that have important ramifications for both ecological and human systems. The scientists and technical professionals at the U.S. Geological Survey Fort Collins Science Center?many of whom are at the forefront of their fields?possess a unique blend of ecological, socioeconomic, and technological expertise. Because of this diverse talent, Fort Collins Science Center staff are able to apply a systems approach to investigating complicated ecological problems in a way that helps answer critical management questions. In addition, the Fort Collins Science Center has a long record of working closely with the academic community through cooperative agreements and other collaborations. The Fort Collins Science Center is deeply engaged with other U.S. Geological Survey science centers and partners throughout the Department of the Interior. As a regular practice, we incorporate the expertise of these partners in providing a full complement of ?the right people? to effectively tackle the multifaceted research problems of today's resource-management world. In Fiscal Year 2009, the Fort Collins Science Center's scientific and technical professionals continued research vital to Department of the Interior's science and management needs. Fort Collins Science Center work also supported the science needs of other Federal and State agencies as well as non-government organizations. Specifically, Fort Collins Science Center research and technical assistance focused on client and partner needs and goals in the areas of biological information management and delivery, enterprise information, fisheries and aquatic systems, invasive species, status and trends of biological resources (including human dimensions), terrestrial ecosystems, and wildlife resources. In the process, Fort Collins Science Center science addressed natural-science information needs identified in the U

Parents' Attitudes Towards Science and their Children's Science Achievement

Science.gov (United States)

Perera, Liyanage Devangi H.

2014-12-01

Although countries worldwide are emphasizing the importance of science education for technological development and global economic competition, comparative findings from standardized international student assessments reveal a huge gap in science scores between developed and developing countries. Certain developed economies too have made little progress in raising science achievement over the past decade. Despite school improvement being placed high on the policy agenda, the results of such actions have been poor. Therefore, there is a need to explore additional ways in which science achievement can be enhanced. This study focuses on the family and examines whether parents' attitudes towards science (how much they value science and the importance they place on it) can influence their children's science achievement. Individual- and school-level data are obtained from the Program for International Student Assessment 2006 survey for 15 Organisation for Economic Co-operation and Development (OECD) and non-OECD countries. Hierarchical linear modelling is employed to estimate the equations. The findings indicate that parents' attitudes towards science have a positive and statistically significant effect on science achievement, after controlling for other important student- and school-level variables. Moreover, students from poor backgrounds appear to benefit from more positive parental science attitudes as much as students from high socioeconomic status, such that equality of student achievement is not affected. This study recommends that schools and teachers encourage parents to play a more pro-active role in their children's science education, as well as educate parents about the importance of science and strategies that can be adopted to support their children's science learning.

Existing data sources in clinical epidemiology: the Scandinavian Thrombosis and Cancer Cohort

Directory of Open Access Journals (Sweden)

Jensvoll H

2015-09-01

Full Text Available Hilde Jensvoll,1,2 Marianne T Severinsen,3,4 Jens Hammerstrøm,5 Sigrid K Brækkan,1,2 Søren R Kristensen,4,6 Suzanne C Cannegieter,7 Kristine Blix,1,2 Anne Tjønneland,8 Frits R Rosendaal,1,7,9 Olga Dziewiecka,1 Kim Overvad,10,11 Inger Anne Næss,12 John-Bjarne Hansen1,21Department of Clinical Medicine, KG Jebsen – Thrombosis Research and Expertise Center (TREC, UiT – The Arctic University of Norway, 2Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway; 3Department of Hematology, Aalborg University Hospital, 4Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; 5Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway; 6Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark; 7Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; 8Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark; 9Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands; 10Department of Cardiology, Aalborg University Hospital, Aalborg, 11Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark; 12Department of Hematology, Trondheim University Hospital, Trondheim, NorwayBackground: Although venous thromboembolism (VTE is a known common complication in cancer patients, there is limited knowledge on patient-related and cancer-specific risk factors in the general population. The Scandinavian Thrombosis and Cancer (STAC Cohort was established by merging individual data from three large Scandinavian cohorts (The Tromsø Study, the second Nord-Trøndelag Health Study, and the Danish Diet, Cancer and Health Study. Here, we present the profile of the STAC cohort and provide age-specific incidence rates of VTE and cancerMethods: The STAC cohort includes 144,952 subjects aged 19–101 years

Science + Maths = A Better Understanding of Science!

Science.gov (United States)

Markwick, Andy; Clark, Kris

2016-01-01

Science and mathematics share a common purpose: to explore, understand and explain the pure beauty of our universe and how it works. Using mathematics in science enquiry can enhance children's understanding of science and also provide opportunities for children to apply their mathematical knowledge to "real" contexts. The authors…

Common Earth Science Misconceptions in Science Teaching

Science.gov (United States)

King, Chris

2012-01-01

A survey of the Earth science content of science textbooks found a wide range of misconceptions. These are discussed in this article with reference to the published literature on Earth science misconceptions. Most misconceptions occurred in the "sedimentary rocks and processes" and "Earth's structure and plate tectonics"…

Environmental science: A new opportunity for soil science

Energy Technology Data Exchange (ETDEWEB)

Pepper, I.L.

2000-01-01

During the golden era of soil science--from the 1950s to the 1980s--the main focus of this discipline was on the role of soil in production agriculture. More recently, renewed interest in the area of environmental science has offered new opportunities to soil scientists. Thus, many soil scientists are now working in areas such as bioremediation, waste recycling, and/or contaminant transport. Environmental science has, therefore, not only changed the traditional research role of soil scientists at land grant institutions but has also influenced student enrollment, the traditional soil science curriculum, and faculty recruitment. These changes require a new breed of soil scientist, one with a background not only in soil science but also in other areas of environmental science as well.

Connecting university science experiences to middle school science teaching

Science.gov (United States)

Johnson, Gordon; Laughran, Laura; Tamppari, Ray; Thomas, Perry

1991-06-01

Science teachers naturally rely on their university science experiences as a foundation for teaching middle school science. This foundation consists of knowledge far too complex for the middle level students to comprehend. In order for middle school science teachers to utilize their university science training they must search for ways to adapt their college experiences into appropriate middle school learning experience. The criteria set forth above provide broad-based guidelines for translating university science laboratory experiences into middle school activities. These guidelines are used by preservice teachers in our project as they identify, test, and organize a resource file of hands-on inquiry activities for use in their first year classrooms. It is anticipated that this file will provide a basis for future curriculum development as the teacher becomes more comfortable and more experienced in teaching hands-on science. The presentation of these guidelines is not meant to preclude any other criteria or considerations which a teacher or science department deems important. This is merely one example of how teachers may proceed to utilize their advanced science training as a basis for teaching middle school science.

Senator Fred Harris's National Social Science Foundation proposal: Reconsidering federal science policy, natural science-social science relations, and American liberalism during the 1960s.

Science.gov (United States)

Solovey, Mark

2012-03-01

During the 1960s, a growing contingent of left-leaning voices claimed that the social sciences suffered mistreatment and undue constraints within the natural science-dominated federal science establishment. According to these critics, the entrenched scientific pecking order in Washington had an unreasonable commitment to the unity of the sciences, which reinforced unacceptable inequalities between the social and the natural sciences. The most important political figure who advanced this critique, together with a substantial legislative proposal for reform, was the Oklahoma Democratic Senator Fred Harris. Yet histories of science and social science have told us surprisingly little about Harris. Moreover, existing accounts of his effort to create a National Social Science Foundation have misunderstood crucial features of this story. This essay argues that Harris's NSSF proposal developed into a robust, historically unique, and increasingly critical liberal challenge to the post-World War II federal science establishment's treatment of the social sciences as "second-class citizens."

Hormesis in Regulatory risk assessment - Science and Science Policy.

Science.gov (United States)

Gray, George

2011-01-01

This brief commentary will argue that whether hormesis is considered in regulatory risk assessment is a matter less of science than of science policy. I will first discuss the distinction between science and science policy and their roles in regulatory risk assessment. Then I will focus on factors that influence science policy, especially as it relates to the conduct of risk assessments to inform regulatory decisions, with a focus on the U.S. Environmental Protection Agency (EPA). The key questions will then be how does hormesis interact with current concepts of science and science policy for risk assessment? Finally, I look ahead to factors that may increase, or decrease, the likelihood of hormesis being incorporated into regulatory risk assessment.

The rightful place of science science on the verge

CERN Document Server

2016-01-01

A crisis looms over the scientific enterprise. Not a day passes without news of retractions, failed replications, fraudulent peer reviews, or misinformed science-based policies. The social implications are enormous, yet this crisis has remained largely uncharted—until now. In Science on the Verge, luminaries in the field of post-normal science and scientific governance focus attention on worrying fault-lines in the use of science for policymaking, and the dramatic crisis within science itself. This provocative new volume in The Rightful Place of Science also explores the concepts that need to be unlearned, and the skills that must be relearned and enhanced, if we are to restore the legitimacy and integrity of science.

Book Reviews

Directory of Open Access Journals (Sweden)

Roxana Waterson

1993-01-01

Full Text Available - Donald F. Barr, J. Noorduyn, A critical survey of studies on the languages of Sulawesi, Leiden: KITLV Press, (Bibliographical Series 18, 1991, xiv + 245 pp., maps, index. - J. Boneschansker, H. Reenders, Alternatieve zending, Ottho Gerhard Heldring (1804-1876 en de verbreiding van het christendom in Nederlands-Indië, Kampen, 1991. - H.J.M. Claessen, Albert B. Robillard, Social change in the Pacific Islands. London & New York: Kegan Paul International. 1992, 507 pp. Maps, bibl. - Will Derks, J.J. Ras, Variation, transformation and meaning: Studies on Indonesian literatures in honour of A. Teeuw, Leiden: KITLV Press, (VKI 144, 1991, 236 pp., S.O. Robson (eds. - Will Derks, G.L. Koster, In deze tijd maar nauwelijks te vinden; De Maleise roman van hofjuffer Tamboehan, Vertaald uit het Maleis en ingeleid door G.L. Koster en H.M.J. Maier, Leiden: E.J. Brill, 1991, 174 pp., H.M.J. Maier (eds. - Mark Durie, C.D. Grijns, Jakarta Malay: a multi-dimensional approach to spacial variation. 2 vols., Leiden: KITLV Press, ( VKI 149, 1991. - Jan Fontein, Jan J. Boeles, The secret of Borobudur, Bangkok, privately published, 1985, 90 pp. + appendix, 29 pp. - M. Heins, L. Suryadinata, Military ascendancy and political culture: A study of Indonesia’s Golkar. Ohio: Ohio University, Monographs in International Studies, Southeast Asia Series, no.85, 1989, xiii + 223 pp. - V.J.H. Houben, Ismail Hussein, Antara dunia Melayu dengan dunia kebangsaan. Bangi: penerbit Universiti kebangsaan Malaysia 1990, 68 pp. - Victor T. King, Aruna Gopinath, Pahang 1880-1933: A political history (Monograph/Malaysian branch of the royal Asiatic society, 18. - G.J. Knaap, J. van Goor, Generale Missiven van Gouverneurs-Generaal en Raden aan heren XVII der Verenigde Oostindische Compagnie, IX: 1729-1737 (Rijks Geschiedkundige publicatiën, grote serie 205. ‘s- Gravenhage: Instituut voor Nederlandse Geschiedenis, 1988, xii + 895 p. - Otto D. van den Muijzenberg, John S. Furnivall, The

Science and religion: implications for science educators

Science.gov (United States)

Reiss, Michael J.

2010-03-01

A religious perspective on life shapes how and what those with such a perspective learn in science; for some students a religious perspective can hinder learning in science. For such reasons Staver's article is to be welcomed as it proposes a new way of resolving the widely perceived discord between science and religion. Staver notes that Western thinking has traditionally postulated the existence and comprehensibility of a world that is external to and independent of human consciousness. This has led to a conception of truth, truth as correspondence, in which our knowledge corresponds to the facts in this external world. Staver rejects such a conception, preferring the conception of truth as coherence in which the links are between and among independent knowledge claims themselves rather than between a knowledge claim and reality. Staver then proposes constructivism as a vehicle potentially capable of resolving the tension between religion and science. My contention is that the resolution between science and religion that Staver proposes comes at too great a cost—both to science and to religion. Instead I defend a different version of constructivism where humans are seen as capable of generating models of reality that do provide richer and more meaningful understandings of reality, over time and with respect both to science and to religion. I argue that scientific knowledge is a subset of religious knowledge and explore the implications of this for science education in general and when teaching about evolution in particular.

Journal of Earth System Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

State Key Laboratory of Remote Sensing Science, Faculty of Geographical Science, Beijing Normal University, Beijing 100875, China. Earth Sciences Department, Faculty of Science, University of Kufa, Najaf 34003, Iraq. College of Resource Environment and Tourism, Capital Normal University, Beijing 100048, China.

Globalisation and science education: Rethinking science education reforms

Science.gov (United States)

Carter, Lyn

2005-05-01

Like Lemke (J Res Sci Teach 38:296-316, 2001), I believe that science education has not looked enough at the impact of the changing theoretical and global landscape by which it is produced and shaped. Lemke makes a sound argument for science education to look beyond its own discourses toward those like cultural studies and politics, and to which I would add globalisation theory and relevant educational studies. Hence, in this study I draw together a range of investigations to argue that globalisation is indeed implicated in the discourses of science education, even if it remains underacknowledged and undertheorized. Establishing this relationship is important because it provides different frames of reference from which to investigate many of science education's current concerns, including those new forces that now have a direct impact on science classrooms. For example, one important question to investigate is the degree to which current science education improvement discourses are the consequences of quality research into science teaching and learning, or represent national and local responses to global economic restructuring and the imperatives of the supranational institutions that are largely beyond the control of science education. Developing globalisation as a theoretical construct to help formulate new questions and methods to examine these questions can provide science education with opportunities to expand the conceptual and analytical frameworks of much of its present and future scholarship.

New concepts of science and medicine in science and technology studies and their relevance to science education.

Science.gov (United States)

Wang, Hsiu-Yun; Stocker, Joel F; Fu, Daiwie

2012-02-01

Science education often adopts a narrow view of science that assumes the lay public is ignorant, which seemingly justifies a science education limited to a promotional narrative of progress in the form of scientific knowledge void of meaningful social context. We propose that to prepare students as future concerned citizens of a technoscientific society, science education should be informed by science, technology, and society (STS) perspectives. An STS-informed science education, in our view, will include the following curricular elements: science controversy education, gender issues, historical perspective, and a move away from a Eurocentric view by looking into the distinctive patterns of other regional (in this case of Taiwan, East Asian) approaches to science, technology, and medicine. This article outlines the significance of some major STS studies as a means of illustrating the ways in which STS perspectives can, if incorporated into science education, enhance our understanding of science and technology and their relationships with society. Copyright © 2011. Published by Elsevier B.V.

New concepts of science and medicine in science and technology studies and their relevance to science education

Directory of Open Access Journals (Sweden)

Hsiu-Yun Wang

2012-02-01

Full Text Available Science education often adopts a narrow view of science that assumes the lay public is ignorant, which seemingly justifies a science education limited to a promotional narrative of progress in the form of scientific knowledge void of meaningful social context. We propose that to prepare students as future concerned citizens of a technoscientific society, science education should be informed by science, technology, and society (STS perspectives. An STS-informed science education, in our view, will include the following curricular elements: science controversy education, gender issues, historical perspective, and a move away from a Eurocentric view by looking into the distinctive patterns of other regional (in this case of Taiwan, East Asian approaches to science, technology, and medicine. This article outlines the significance of some major STS studies as a means of illustrating the ways in which STS perspectives can, if incorporated into science education, enhance our understanding of science and technology and their relationships with society.

Learning Science, Learning about Science, Doing Science: Different Goals Demand Different Learning Methods

Science.gov (United States)

Hodson, Derek

2014-01-01

This opinion piece paper urges teachers and teacher educators to draw careful distinctions among four basic learning goals: learning science, learning about science, doing science and learning to address socio-scientific issues. In elaboration, the author urges that careful attention is paid to the selection of teaching/learning methods that…

Ketenregie hard nodig. Siem van Merrienboer (TNO) over slimmere bouwlogistiek

NARCIS (Netherlands)

Merrienboer, S.A. van

2015-01-01

Er is nog veel te winnen bij de logistieke processen in de bouw met zogenoemde proeftuin bouwprojecten willen diverse partijen samen ervaringen opdoen en vaststellen wat wel en niet werkt. Initiatiefnemers in Tno in Delft

Science.gov: gateway to government science information.

Science.gov (United States)

Fitzpatrick, Roberta Bronson

2010-01-01

Science.gov is a portal to more than 40 scientific databases and 200 million pages of science information via a single query. It connects users to science information and research results from the U.S. government. This column will provide readers with an overview of the resource, as well as basic search hints.

Recommendation on measures to safeguard freedom of expression and undistorted competition in EU trade mark law

DEFF Research Database (Denmark)

Minssen, Timo

2015-01-01

, University of Oxford, United Kingdom Christophe Geiger Associate Professor, Director General and Director of the Research Department, Centre for International Intellectual Property Studies, University of Strasbourg, France Gustavo Ghidini Professor of Intellectual Property and Competition Law, University...... Institute for Innovation and Competition, Munich, Germany Paul van der Kooij Associate Professor of Intellectual Property Law, Leiden Law School, University of Leiden, The Netherlands Annette Kur Senior Researcher, Max Planck Institute for Innovation and Competition, Munich, and Honorary Professor...... Professor of Commercial Law, University of Parma, Italy Timo Minssen Associate Professor, Centre for Information and Innovation Law, University of Copenhagen, Denmark Ansgar Ohly Professor of Civil Law, Intellectual Property and Competition Law, University of Munich, Germany Alexander Peukert Professor...

Physical Sciences 2007 Science and Technology Highlights

International Nuclear Information System (INIS)

Hazi, A.U.

2008-01-01

The Physical Sciences Directorate applies frontier physics and technology to grand challenges in national security. Our highly integrated and multidisciplinary research program involves collaborations throughout Lawrence Livermore National Laboratory, the National Nuclear Security Administration, the Department of Energy, and with academic and industrial partners. The Directorate has a budget of approximately $150 million, and a staff of approximately 350 employees. Our scientists provide expertise in condensed matter and high-pressure physics, plasma physics, high-energy-density science, fusion energy science and technology, nuclear and particle physics, accelerator physics, radiation detection, optical science, biotechnology, and astrophysics. This document highlights the outstanding research and development activities in the Physical Sciences Directorate that made news in 2007. It also summarizes the awards and recognition received by members of the Directorate in 2007

Science and Society - Problems, issues and dilemmas in science education

CERN Multimedia

2001-01-01

Next in CERN's series of Science and Society speakers is Jonathan Osborne, Senior Lecturer in Science Education at King's College London. On Thursday 26 April, Dr Osborne will speak in the CERN main auditorium about current issues in science education in the light of an ever more science-based society. Jonathan Osborne, Senior Lecturer in Science Education at King's College London. Does science deserve a place at the curriculum high table of each student or is it just a gateway to a set of limited career options in science and technology? This question leads us to an important change in our ideas of what science education has been so far and what it must be. Basic knowledge of science and technology has traditionally been considered as just a starting point for those who wanted to build up a career in scientific research. But nowadays, the processes of science, the analysis of risks and benefits, and a knowledge of the social practices of science are necessary for every citizen. This new way of looking at s...

Exploring Girls' Science Affinities Through an Informal Science Education Program

Science.gov (United States)

Todd, Brandy; Zvoch, Keith

2017-10-01

This study examines science interests, efficacy, attitudes, and identity—referred to as affinities, in the context of an informal science outreach program for girls. A mixed methods design was used to explore girls' science affinities before, during, and after participation in a cohort-based summer science camp. Multivariate analysis of survey data revealed that girls' science affinities varied as a function of the joint relationship between family background and number of years in the program, with girls from more affluent families predicted to increase affinities over time and girls from lower income families to experience initial gains in affinities that diminish over time. Qualitative examination of girls' perspectives on gender and science efficacy, attitudes toward science, and elements of science identities revealed a complex interplay of gendered stereotypes of science and girls' personal desires to prove themselves knowledgeable and competent scientists. Implications for the best practice in fostering science engagement and identities in middle school-aged girls are discussed.

Evaluation Science

Science.gov (United States)

Patton, Michael Quinn

2018-01-01

Culturally and politically science is under attack. The core consequence of perceiving and asserting evaluation as science is that it enhances our credibility and effectiveness in supporting the importance of science in our world and brings us together with other scientists to make common cause in supporting and advocating for science. Other…

The Nature of Science and Science Education: A Bibliography

Science.gov (United States)

Bell, Randy; Abd-El-Khalick, Fouad; Lederman, Norman G.; Mccomas, William F.; Matthews, Michael R.

Research on the nature of science and science education enjoys a long history, with its origins in Ernst Mach's work in the late nineteenth century and John Dewey's at the beginning of the twentieth century. As early as 1909 the Central Association for Science and Mathematics Teachers published an article - A Consideration of the Principles that Should Determine the Courses in Biology in Secondary Schools - in School Science and Mathematics that reflected foundational concerns about science and how school curricula should be informed by them. Since then a large body of literature has developed related to the teaching and learning about nature of science - see, for example, the Lederman (1992)and Meichtry (1993) reviews cited below. As well there has been intense philosophical, historical and philosophical debate about the nature of science itself, culminating in the much-publicised Science Wars of recent time. Thereferences listed here primarily focus on the empirical research related to the nature of science as an educational goal; along with a few influential philosophical works by such authors as Kuhn, Popper, Laudan, Lakatos, and others. While not exhaustive, the list should prove useful to educators, and scholars in other fields, interested in the nature of science and how its understanding can be realised as a goal of science instruction. The authors welcome correspondence regarding omissions from the list, and on-going additions that can be made to it.

A Compact Fluorescence Lifetime Excitation-Emission Spectrometer (FLEXEMS) for Detecting Trace Organics, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — In this Small Business Innovative Research (SBIR) effort, Leiden Measurement Technology (LMT) proposes to design and build the Fluorescence Lifetime Excitation...

A Compact Fluorescence Lifetime Excitation-Emission Spectrometer (FLEXEMS) for Detecting Trace Organics, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — In this Small Business Innovative Research (SBIR) effort, Leiden Measurement Technology (LMT) proposes to design and build the Fluorescence Lifetime Excitation...

Science et Technique, Sciences de la Santé

African Journals Online (AJOL)

AFRICAN JOURNALS ONLINE (AJOL) · Journals · Advanced Search · USING AJOL · RESOURCES. Science et Technique, Sciences de la Santé. Journal Home > Vol ... The journal is focused on health sciences in general. It publishes articles ...

Taking the Lead in Science Education: Forging Next-Generation Science Standards. International Science Benchmarking Report. Appendix

Science.gov (United States)

Achieve, Inc., 2010

2010-01-01

This appendix accompanies the report "Taking the Lead in Science Education: Forging Next-Generation Science Standards. International Science Benchmarking Report," a study conducted by Achieve to compare the science standards of 10 countries. This appendix includes the following: (1) PISA and TIMSS Assessment Rankings; (2) Courses and…

Ultra-fast calculations using diamond

NARCIS (Netherlands)

Van Dijk, T.

2011-01-01

TU Delft researchers have managed to use a piece of diamond to hold four quantum bits that can be spun, flipped and entangled with each other. This is an important step towards a working quantum computer

Other Women in Science Groups | Women in Science | Initiatives ...

Indian Academy of Sciences (India)

... Proceedings – Mathematical Sciences · Resonance – Journal of Science ... The Department of Science & Technology has set up a National Task Force on Women ... The International Union of Pure and Applied Physics (IUPAP) has set up a ... the area of Science in Society under its Research and Innovation programmes.

Slavery, religion, and abolition in Suriname

Directory of Open Access Journals (Sweden)

Johannes Postma

1997-07-01

Full Text Available [First paragraph] "Om werk van jullie te hebben": Plantageleven in Suriname, 1730-1750. RUDI OTTO BEELDSNIJDER. Utrecht: Vakgroep Culturele Antropologie - Bronnen voor de Studie van Afro-Surinaamse Samenlevingen, 1994. xii + 351 pp. (Paper NLG 35.00 Surinaams contrast: Roofbouw en overleven in een Caraibische plantagekolonie 1750-1863. ALEX VAN STIPRIAAN. Leiden: KITLV Press, 1995. xiii + 494 pp. (Paper NLG 60.00 Strijders voor het Lam: Leven en werk van Herrnhutter broeders en zusters in Suriname, 1735-1900. MARIA LENDERS. Leiden: KITLV Press, 1996. xii + 451 pp. (Paper NLG 65.00 Fifty Years Later: Antislavery, Capitalism and Modernity in the Dutch Orbit. GERT OOSTINDIE (ed.. Leiden: KITLV Press, 1995; Pittsburgh: University of Pittsburgh Press, 1996. viii + 272 pp. (Paper NLG 45.00, US$ 22.50, Cloth US$ 45.00 The publication of the books under review is evidence of a growing scholarly interest in the history of Dutch activities in the Atlantic. Three of them are doctoral dissertations on Suriname history; the fourth contains the published proceedings of a conference held in 1993 that focused on the abolition of slavery in the Dutch colonies. Three were published by the Royal Institute of Linguistics and Anthropology (KITLV, which exhibits an increasing interest in publishing scholarly books about Dutch overseas history.

Elucidating elementary science teachers' conceptions of the nature of science: A view to beliefs about both science and teaching

Science.gov (United States)

Keske, Kristina Palmer

The purpose of this interpretive case study was to elucidate the conceptions of the nature of science held by seven elementary science teachers. The constructivist paradigm provided the philosophical and methodological foundation for the study. Interviews were employed to collect data from the participants about their formal and informal experiences with science. In addition, the participants contributed their perspectives on four aspects of the nature of science: what is science; who is a scientist; what are the methods of science; and how is scientific knowledge constructed. Data analysis not only revealed these teachers' views of science, but also provided insights into how they viewed science teaching. Four themes emerged from the data. The first theme developed around the participants' portrayals of the content of science, with participant views falling on a continuum of limited to universal application of science as procedure. The second theme dealt with the participants' views of the absolute nature of scientific knowledge. Participants' perceptions of the tentative nature of science teaching provided the basis for the third theme concerning the need for absolutes in practice. The fourth theme drew parallels between participants' views of science and science teaching, with two participants demonstrating a consistency in beliefs about knowledge construction across contexts. This study revealed both personal and contextual factors which impacted how the participants saw science and science teaching. Many of the participants' memories of formal science revolved around the memorization of content and were viewed negatively. All the participants had limited formal training in science. Of the seven participants, only two had chosen to be science teachers at the beginning of their careers. The participants' limited formal experiences with science provided little time for exploration into historical, philosophical, and sociological studies of science, a necessary

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

College of Materials Science and Engineering, Guilin University of Electronic Technology, Guilin 541004, China; Guangxi Key Laboratory of Information Materials, Guilin University of Electronic Technology, Guilin 541004, China; Department of Materials Science and Engineering, Luoyang Institute of Science and ...

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand; Department of Physics, Faculty of Science and Technology, Thammasat University, Khlong Luang, Pathum Thani, 12120, Thailand; Department of Chemistry, Faculty of Science, Thaksin University, Papayom, ...

Home Culture, Science, School and Science Learning: Is Reconciliation Possible?

Science.gov (United States)

Tan, Aik-Ling

2011-01-01

In response to Meyer and Crawford's article on how nature of science and authentic science inquiry strategies can be used to support the learning of science for underrepresented students, I explore the possibly of reconciliation between the cultures of school, science, school science as well as home. Such reconciliation is only possible when…

International production on science oriented towards data: analysis of the terms data science and e-science in scopus and the web of science

Directory of Open Access Journals (Sweden)

Leilah Santiago Bufrem

2016-08-01

Full Text Available Introduction: current configuration in the dynamics of production and scientific communication reveals the role of Science Oriented Towards Data, a comprehensive conception represented, mainly, by terms such as "e-Science" and "Data Science". Objective: To present the global scientific production on Science Oriented Towards Data by using the terms "e-Science" and "Data Science" in Scopus and the Web of Science during 2006-2016. Methodology: The study is divided into five phases: a search for information in Scopus and the Web of Science data bases; b obtaining bibliometric records; c complementing keywords; d data correction and crossing; e analytical data representation. Results: The most important terms within the analyzed scientific production were Distributed computer systems (2006, Grid computing (2007-2013 and Big data (2014- 2016. In the area of Library and Information Science, the emphasis was on Digital Library and Open Access issues, highlighting the importance of the field for the discussions on the devices providing access to scientific information in digital media. Conclusions: Under a diachronic look, it was found a visible shift of focus, from issues approaching data exchange operations to an analytical perspective for finding patterns in large data volumes

Mars: A Freshmen Year Seminar of Science and Science-fiction

Science.gov (United States)

Svec, Michael; Moffett, D. A.; Winiski, M.

2013-06-01

"Mars: On the shoulder of giants" is a freshmen year seminar developed collaboratively between the physics, education, and center for teaching and learning. This course focuses on how scientific knowledge is developed through the lens of our changing view of Mars throughout history. Analyses of current studies of Mars are juxtaposed against historical understanding and perceptions of the planet found in scientific and popular literature of the day, as well as the movies. Kim Stanley Robinson’s "Red Mars" provides a unifying story throughout the course complimented by Fredrick Taylor’s "The Scientific Exploration of Mars" and Hartmann’s "A Traveler’s Guide to Mars." Based on the three-years of experience, the authors advocate the use of the speculative science-fiction novel and argue for its use in high school and undergraduate courses including those for science majors. Many of the students who selected this seminar went on to major in science and in subsequent interviews discussed the influence of science fiction on their decision to major in science. Science fiction provided story, science, and speculation that became a rich medium for critical-thinking skills and critical literacy. Student reflections indicated that science fiction served as a reminder of why they study science, a source for imagination, and exploration of science as a human endeavor. Based on this experience, we propose five elements for selecting science-fiction for inclusion in science classes: 1) Provides a deep description of the science content or technologies, 2) Describes science and technologies are plausible or accurate to the time period, 3) Contains a novum or plausible innovation that plays a key element in the speculation, 4) Exploration of the impact on society or humanity, and, 5) Shows science and technology as human endeavors.

Patients’ perceptions of conservative treatment for a small abdominal aortic aneurysm

Directory of Open Access Journals (Sweden)

Tomee SM

2018-01-01

Full Text Available Stephanie M Tomee,1 Winifred A Gebhardt,2 Jean-Paul PM de Vries,3 Victoria C Hamelinck,1 Jaap F Hamming,1 Jan HN Lindeman1 1Department of Surgery, Leiden University Medical Center, Leiden, 2Health, Medical and Neuropsychology Unit, Institute of Psychology, Leiden University, Leiden, 3Department of Vascular Surgery, St Antonius Hospital, Nieuwegein, Leiden, the Netherlands Background: An abdominal aortic aneurysm (AAA is a progressive, generally symptomless disease that could ultimately result in a fatal rupture. Current guidelines advise conservative follow-up, and preventive surgical repair once the risk of rupture outweighs the cost of repair (55 mm in men. In developed countries, the majority of patients are diagnosed with AAAs less than 55 mm, and so enter a period of conservative surveillance. An important question is how patients perceive and cope with risk of rupture, AAA diagnosis and treatment, and presented AAA information. The goal of this study was to gain insight into patients’ perceptions of conservative treatment for a small AAA to increase patient satisfaction.Methods: We conducted semistructured in-depth interviews and used questionnaires measuring health-related quality of life (RAND 36-Item Health Survey 1.0, illness-perceptions (Illness Perception Questionnaire – Revised, and anxiety and depression (Hospital Anxiety and Depression Scale. Interviews were audio recorded and transcript contents were analyzed based on grounded theory. Mean scores of the questionnaires were compared to (population reference groups.Results: This study included ten male patients under surveillance for a small AAA from two hospitals in the Netherlands. Patients expressed no fear for AAA rupture, and also reported low levels of anxiety and depression in both the interviews and the Hospital Anxiety and Depression Scale. The presence of an AAA did not affect their social life or emotional well-being. The reported poorer physical health on RAND 36

Book Reviews

Directory of Open Access Journals (Sweden)

Simon Kooijman

1984-01-01

Full Text Available - Gerard J. van den Broek, G. Varro, Orients, pour Georges Condominas. R. Hamayon, J. Matras-Troubetzkoy, J. Pouillon, L, Puiseux, Ch. Taillard, Toulouse, Editions Privat & Paris, Sudestasie, 1981, 345 pp., B. Condominas (eds. - M. Haddad, Nels Johnson, Islam and the politics of meaning in Palestinian nationalism, London: Kegan Paul International, 1982. - A. de Ruijter, Mary Douglas, In the active voice, London, Boston and Henley: Routledge and Kegan Paul, 1982, xi + 306 pp. - Peter Kloos, Paul Henley, The Panare. Tradition and change on the Amazonian frontier. New Haven, Yale University Press, 1982, 263 pp. - Peter Kloos, Conrad Phillip Kottak, Assault on Paradise. Social change in a Brazilian village. New York: Random House, 1983, 314 pp. - W.A. Shadid, M. van der Most van Spijk, Remember to be firm. Life histories of three Egyptian women, Women and development series, Cairo/Leiden 1982. 79 pp., H.Y. Fahmy, S. Zimmerman (eds. - W.A. Shadid, Marileen van der Most van Spijk, Eager to learn. An anthropological study of the needs of Egyptian village women; report of an experiment, Women and development series, Cairo/Leiden 1982. 84 pp. - W.A. Shadid, Marileen van der Most van Spijk, Who cares for her health? An anthropological study of women’s health care in a village in Upper Egypt, Women and development series, Cairo/Leiden 1982. 99 pp. - Willem van Schendel, Marvin Davis, Rank and rivalry: The politics of inequality in rural West Bengal, Cambridge: Cambridge University Press, 1983. - Simon Kooijman, Jerry W. Leach, The Kula, New perspectives on Massim exchange. Cambridge University Press, Cambridge, New York, New Rochelle, Melbourne, Sydney, 1983., Edmund Leach (eds. - Simon Kooijman, Martha Macintyre, The Kula. A Bibliography. Cambridge University Press, Cambridge, New York, New Rochelle, Melbourne, Sydney, 1983. - H. Dagmar, C.G. von Brandenstein, Names and substance of the Australian subsection system, The University of Chicago Press, N

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

The Institute for Nanomaterials and Nanotechnology, MAScIR (Moroccan Foundation for Advanced Science, Innovation and Research), Rabat, Morocco; LMPHE (URAC 12), Departement of Physique, BP 1014, Faculty of Science, Mohammed V-Agdal University, Rabat, Morocco; National Centre for Energy, Sciences and ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 29; Issue 5 ... Polyester urethane; scaffold; tensile strength; swelling; degradation; cell culture. ... Materials Science Centre, Indian Institute of Technology, Kharagpur 721 302, India; School of Medical Science and Technology, Indian Institute of Technology, Kharagpur ...

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

... Physics · Proceedings – Mathematical Sciences · Resonance – Journal of Science ... Home; Journals; Journal of Chemical Sciences; Special Issues ... 2nd International Symposium on Materials Chemistry (ISMC-2008) ... New Directions of Research in Molecules and Materials ... Theoretical Models for Molecular Structure.

Proceedings – Mathematical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Proceedings – Mathematical Sciences; Search. Search. Proceedings – Mathematical Sciences. Title. Author. Keywords. Fulltext. Submit. Proceedings – Mathematical Sciences. Current Issue : Vol. 128, Issue 2. Current Issue Volume 128 | Issue 2. April 2018. Home · Volumes & Issues · Special Issues ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

... India; Department of Physics, Sultan Qaboos University, Muscat, P.O. Box 36, Code 123, Oman; Department of Polymer Science andRubber Technology, Cochin University of Science and Technology, Cochin 682022, India; Department of Materials Science and Nanoengineering, Rice University, Houston, TX 77005, USA ...

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

National Initiative on Undergraduate Science (NIUS) Chemistry Programme Fellow, Homi Bhabha Centre for Science Education, Mankhurd, Mumbai, Maharashtra 400 088, India; Department of Chemistry, V. K. Krishna Menon College of Commerce & S. S. Dighe College of Science, Bhandup (E), Mumbai, Maharashtra 400 ...

Science Outside the Lab: Helping Graduate Students in Science and Engineering Understand the Complexities of Science Policy.

Science.gov (United States)

Bernstein, Michael J; Reifschneider, Kiera; Bennett, Ira; Wetmore, Jameson M

2017-06-01

Helping scientists and engineers challenge received assumptions about how science, engineering, and society relate is a critical cornerstone for macroethics education. Scientific and engineering research are frequently framed as first steps of a value-free linear model that inexorably leads to societal benefit. Social studies of science and assessments of scientific and engineering research speak to the need for a more critical approach to the noble intentions underlying these assumptions. "Science Outside the Lab" is a program designed to help early-career scientists and engineers understand the complexities of science and engineering policy. Assessment of the program entailed a pre-, post-, and 1 year follow up survey to gauge student perspectives on relationships between science and society, as well as a pre-post concept map exercise to elicit student conceptualizations of science policy. Students leave Science Outside the Lab with greater humility about the role of scientific expertise in science and engineering policy; greater skepticism toward linear notions of scientific advances benefiting society; a deeper, more nuanced understanding of the actors involved in shaping science policy; and a continued appreciation of the contributions of science and engineering to society. The study presents an efficacious program that helps scientists and engineers make inroads into macroethical debates, reframe the ways in which they think about values of science and engineering in society, and more thoughtfully engage with critical mediators of science and society relationships: policy makers and policy processes.

Effects of Inquiry-Based Science Instruction on Science Achievement and Interest in Science: Evidence from Qatar

Science.gov (United States)

Areepattamannil, Shaljan

2012-01-01

The author sought to investigate the effects of inquiry-based science instruction on science achievement and interest in science of 5,120 adolescents from 85 schools in Qatar. Results of hierarchical linear modeling analyses revealed the substantial positive effects of science teaching and learning with a focus on model or applications and…

Transforming Elementary Science Teacher Education by Bridging Formal and Informal Science Education in an Innovative Science Methods Course

Science.gov (United States)

Riedinger, Kelly; Marbach-Ad, Gili; McGinnis, J. Randy; Hestness, Emily; Pease, Rebecca

2011-01-01

We investigated curricular and pedagogical innovations in an undergraduate science methods course for elementary education majors at the University of Maryland. The goals of the innovative elementary science methods course included: improving students' attitudes toward and views of science and science teaching, to model innovative science teaching…

Incorporating Earth Science into Other High School Science Classes

Science.gov (United States)

Manning, C. L. B.; Holzer, M.; Colson, M.; Courtier, A. M. B.; Jacobs, B. E.

2016-12-01

As states begin to review their standards, some adopt or adapt the NGSS and others write their own, many basing these on the Framework for K-12 Science Education. Both the NGSS and the Frameworks have an increased emphasis on Earth Science but many high school teachers are being asked to teach these standards in traditional Biology, Chemistry and Physics courses. At the Earth Educators Rendezvous, teachers, scientists, and science education researchers worked together to find the interconnections between the sciences using the NGSS and identified ways to reference the role of Earth Sciences in the other sciences during lectures, activities and laboratory assignments. Weaving Earth and Space sciences into the other curricular areas, the teams developed relevant problems for students to solve by focusing on using current issues, media stories, and community issues. These and other lessons and units of study will be presented along with other resources used by teachers to ensure students are gaining exposure and a deeper understanding of Earth and Space Science concepts.

Science Anxiety, Science Attitudes, and Constructivism: A Binational Study

Science.gov (United States)

Bryant, Fred B.; Kastrup, Helge; Udo, Maria; Hislop, Nelda; Shefner, Rachel; Mallow, Jeffry

2013-08-01

Students' attitudes and anxieties about science were measured by responses to two self-report questionnaires. The cohorts were Danish and American students at the upper secondary- and university-levels. Relationships between and among science attitudes, science anxiety, gender, and nationality were examined. Particular attention was paid to constructivist attitudes about science. These fell into at least three broad conceptual categories: Negativity of Science Toward the Individual, Subjective Construction of Knowledge, and Inherent Bias Against Women. Multigroup confirmatory factor analyses revealed that these dimensions of constructivist attitudes were equally applicable and had the same meaning in both cultures. Gender differences in mean levels of constructivist attitudes were found; these varied across the two cultures. Constructivist beliefs were associated with science anxiety, but in different ways for females and males, and for Danes and Americans. In agreement with earlier studies, females in both the US and Danish cohorts were significantly more science anxious than males, and the gender differences for the Americans were larger than those for the Danes. Findings are discussed in terms of their implications for reducing science anxiety by changing constructivist beliefs.

Science/s.

Directory of Open Access Journals (Sweden)

Emmanuelle Tricoire

2005-03-01

Full Text Available Un forum a été organisé en mars par la Commission européenne. Il s’appelait « Science in Society ». Depuis 2000 la Commission a mis en place un Plan d’Action élaboré pour que soit promue « la science » au sein du public, afin que les citoyens prennent de bonnes décisions, des décisions informées. Il s’agit donc de développer la réflexivité au sein de la société, pour que cette dernière agisse avec discernement dans un monde qu’elle travaille à rendre durable. ...

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

... XIONG1 WEIHUA ZHU1 HEMING XIAO1. Institute for Computation in Molecular and Materials Science and Department of Chemistry, School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China; School of Materials Science and Engineering, Nanjing Institute of Technology, ...

Initiatives | Women in Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

This initiative of the Women in Science (WiS) Panel relates to mentoring of young ... The Women in Science Panel (WiS) of Indian Academy of Sciences has ... age of 52, after a valiant battle with cancer, today on 29th March 2016 in Delhi.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Editorial Board. Bulletin of Materials Science. Editor. Giridhar U. Kulkarni, Centre for Nano and Soft Matter Science, Bengaluru. Associate Editors. Ayan Datta, Indian Association for the Cultivation of Science, Kolkata M. Eswaramoorthy, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru A.K. Ganguli ...

Network science, nonlinear science and infrastructure systems

CERN Document Server

2007-01-01

Network Science, Nonlinear Science and Infrastructure Systems has been written by leading scholars in these areas. Its express purpose is to develop common theoretical underpinnings to better solve modern infrastructural problems. It is felt by many who work in these fields that many modern communication problems, ranging from transportation networks to telecommunications, Internet, supply chains, etc., are fundamentally infrastructure problems. Moreover, these infrastructure problems would benefit greatly from a confluence of theoretical and methodological work done with the areas of Network Science, Dynamical Systems and Nonlinear Science. This book is dedicated to the formulation of infrastructural tools that will better solve these types of infrastructural problems. .

Gender roles and science beliefs and their relationship to science interest

Science.gov (United States)

Paolucci, Judith Jean

This study investigated adolescents' views about the nature of science (NOS) and conceptions of their gender identities, and revealed whether these conceptions and views are related to their science interest. Participants were 566 high school students enrolled in chemistry courses at three high schools in a New England state. A questionnaire was used to assess participants' science interest, gender role perceptions, and views about science, as well as to provide background and math and science achievement data. The study found that while student scores of NOS understanding did not differ by gender, some significant differences were noted on the student responses to statements about science. Students with higher-than-average science interest scores responded to these statements differently than students with lower science interest scores; their responses tended to more closely match statements about NOS taken from current reform documents. The study also found that math and science achievement, masculinity scores, and NOS scores accounted for a greater variance of science interest for girls than for boys, though all three also contributed significantly and positively to the regression equation for boys. These predictor variables predicted membership to the lower or higher science interest groups, but could not predict students' career aspiration groups. Thus, other mediating factors not considered in this study may translate high science interest to science career aspiration. The results of this study coed prior research, which found that science and math achievement and masculinity are positively and significantly related to science interest for boy boys and girls. Moreover, the study found that achievement in math and science courses is a greater predictor of science interest for girls than for boys. The results of this study provide a rationale for incorporating the nature of science into the science curriculum. Moreover, since the science interest of boys was

Innovation in Citizen Science – Perspectives on Science-Policy Advances

Directory of Open Access Journals (Sweden)

Susanne Hecker

2018-04-01

Full Text Available Citizen science is growing as a field of research with contributions from diverse disciplines, promoting innovation in science, society, and policy. Inter- and transdisciplinary discussions and critical analyses are needed to use the current momentum to evaluate, demonstrate, and build on the advances that have been made in the past few years. This paper synthesizes results of discussions at the first international citizen science conference of the European Citizen Science Association (ECSA in 2016 in Berlin, Germany, and distills major points of the discourse into key recommendations. To enhance innovation in science, citizen science needs to clearly demonstrate its scientific benefit, branch out across disciplines, and foster active networking and new formats of collaboration, including true co-design with participants. For fostering policy advances, it is important to embrace opportunities for policy-relevant monitoring and policy development and to work with science funders to find adequate avenues and evaluation tools to support citizen science. From a society angle it is crucial to engage with societal actors in various formats that suit participants and to evaluate two-way learning outcomes as well as to develop the transformative role of science communication. We hope that these key perspectives will promote citizen science progress at the science-society-policy interface.

Family experiences, the motivation for science learning and science ...

African Journals Online (AJOL)

Schulze, Salome

Student Motivation for Science Learning questionnaire combined with items investigating family experiences. ... science achievement: inadequate school resources and weak household ..... informal interviews with the science teachers of the.

Science as theater, theater as science

Science.gov (United States)

Lustig, Harry

2002-04-01

Beginning with Bertold Brecht's "Galileo" in 1942 and Friedrich Dürrenmatt's "The Physicists" in 1962, physics and other sciences have served a number of dramatists as backdrops for the exposition of existential problems, as well as the provision of entertainment. Michael Frayn's 1998 play "Copenhagen" broke new ground by giving a central role to the presentation of scientific substance and ideas and to the examination of recent controversial and emotionally charged events in the history of science and of the "real world". A rash of "science plays" erupted. How should we physicists react to this development? Surely, it can be argued, any exposure of science to the public is better than none and will help break down the barriers between the "two cultures". But what if the science or the scientists are badly misrepresented or the play is a weapon to strip science of its legitimacy and its claims to reality and truth? After reviewing a half dozen of the new plays, I conclude that "Copenhagen", though flawed, is not only the best of show, but a positive, even admirable endeavor. The contributions of Bohr, Heisenberg, Born, Schrödinger, and other scientists and their interactions in the golden years of the creation of quantum mechanics are accurately and thrillingly rendered. There may be no better non-technical exposition of complementarity and the uncertainty principle than the one that Frayn puts into the mouths of Bohr and Heisenberg. The treatment of the history of the atomic bomb and Heisenberg's role in Germany's failure to achieve a bomb is another matter. Frayn can also be criticized for applying uncertainly and complementarity to the macroscopic world and, in particular, to human interactions, thereby giving some aid and comfort to the post-modernists. These reservations aside, Copenhagen is a beautiful contribution to the appreciation of science.

USSR report: life sciences. Biomedical and behavioral sciences

International Nuclear Information System (INIS)

1982-09-01

Studies in life sciences, biomedical sciences, and behavioral sciences are reported. The following fields of interest were studied: agricultural biology, biochemistry, biotechnology, environment effects, medical demography, medicine, microbiology, physiology, radiation biology, and human factors engineering. For individual titles, see N82-33989 through N82-33994

Naturalized Philosophy of Science and Natural Science Education.

Science.gov (United States)

Siegel, Harvey

1993-01-01

Reviews the philosophical controversy concerning naturalism, and investigates the role it might play in the science classroom. Argues that science students can benefit from explicit study of this controversy and from explicit consideration of the extent to which philosophy of science can be studied naturalistically. (PR)

It's not rocket science : developing pupils’ science talent in out-of-school science education for primary schools

NARCIS (Netherlands)

Geveke, Carla

2017-01-01

Out-of-school science educational activities, such as school visits to a science center, aim at stimulating pupils’ science talent. Science talent is a developmental potential that takes the form of talented behaviors such as curiosity and conceptual understanding. This dissertation investigates

It's not rocket science : Developing pupils’ science talent in out-of-school science education for Primary Schools

NARCIS (Netherlands)

Geveke, Catherina

2017-01-01

Out-of-school science educational activities, such as school visits to a science center, aim at stimulating pupils’ science talent. Science talent is a developmental potential that takes the form of talented behaviors such as curiosity and conceptual understanding. This dissertation investigates

Preservice Elementary Teachers' Science Self-Efficacy Beliefs and Science Content Knowledge

Science.gov (United States)

Menon, Deepika; Sadler, Troy D.

2016-10-01

Self-efficacy beliefs that relate to teachers' motivation and performance have been an important area of concern for preservice teacher education. Research suggests high-quality science coursework has the potential to shape preservice teachers' science self-efficacy beliefs. However, there are few studies examining the relationship between science self-efficacy beliefs and science content knowledge. The purpose of this mixed methods study is to investigate changes in preservice teachers' science self-efficacy beliefs and science content knowledge and the relationship between the two variables as they co-evolve in a specialized science content course. Results from pre- and post-course administrations of the Science Teaching Efficacy Belief Instrument-B (Bleicher, 2004) and a physical science concept test along with semi-structured interviews, classroom observations and artifacts served as data sources for the study. The 18 participants belonged to three groups representing low, medium and high initial levels of self-efficacy beliefs. A repeated measures multivariate analysis of variance design was used to test the significance of differences between the pre- and post-surveys across time. Results indicated statistically significant gains in participants' science self-efficacy beliefs and science conceptual understandings. Additionally, a positive moderate relationship between gains in science conceptual understandings and gains in personal science teaching efficacy beliefs was found. Qualitative analysis of the participants' responses indicated positive shifts in their science teacher self-image and they credited their experiences in the course as sources of new levels of confidence to teach science. The study includes implications for preservice teacher education programs, science teacher education, and research.

DES Science Portal: II- Creating Science-Ready Catalogs

Energy Technology Data Exchange (ETDEWEB)

Fausti Neto, Angelo; et al.

2017-08-18

We present a novel approach for creating science-ready catalogs through a software infrastructure developed for the Dark Energy Survey (DES). We integrate the data products released by the DES Data Management and additional products created by the DES collaboration in an environment known as DES Science Portal. Each step involved in the creation of a science-ready catalog is recorded in a relational database and can be recovered at any time. We describe how the DES Science Portal automates the creation and characterization of lightweight catalogs for DES Year 1 Annual Release, and show its flexibility in creating multiple catalogs with different inputs and configurations. Finally, we discuss the advantages of this infrastructure for large surveys such as DES and the Large Synoptic Survey Telescope. The capability of creating science-ready catalogs efficiently and with full control of the inputs and configurations used is an important asset for supporting science analysis using data from large astronomical surveys.

Science As A Second Language: Acquiring Fluency through Science Enterprises

Science.gov (United States)

Shope, R.; EcoVoices Expedition Team

2013-05-01

Science Enterprises are problems that students genuinely want to solve, questions that students genuinely want to answer, that naturally entail reading, writing, investigation, and discussion. Engaging students in personally-relevant science enterprises provides both a diagnostic opportunity and a context for providing students the comprehensible input they need. We can differentiate instruction by creating science enterprise zones that are set up for the incremental increase in challenge for the students. Comprehensible input makes reachable, those just-out-of-reach concepts in the mix of the familiar and the new. EcoVoices takes students on field research expeditions within an urban natural area, the San Gabriel River Discovery Center. This project engages students in science enterprises focused on understanding ecosystems, ecosystem services, and the dynamics of climate change. A sister program, EcoVoces, has been launched in Mexico, in collaboration with the Universidad Loyola del Pacífico. 1) The ED3U Science Inquiry Model, a learning cycle model that accounts for conceptual change: Explore { Diagnose, Design, Discuss } Use. 2) The ¿NQUIRY Wheel, a compass of scientific inquiry strategies; 3) Inquiry Science Expeditions, a way of laying out a science learning environment, emulating a field and lab research collaboratory; 4) The Science Educative Experience Scale, a diagnostic measure of the quality of the science learning experience; and 5) Mimedia de la Ciencia, participatory enactment of science concepts using techniques of mime and improvisational theater. BACKGROUND: Science has become a vehicle for teaching reading, writing, and other communication skills, across the curriculum. This new emphasis creates renewed motivation for Scientists and Science Educators to work collaboratively to explore the common ground between acquiring science understanding and language acquisition theory. Language Acquisition is an informal process that occurs in the midst of

Science access, career choices, achievement, and motivation: Perceptions of female science olympians

Science.gov (United States)

Price, Kelly Rae

Women remain under-represented in science career fields and this is especially evident in the physical sciences. Female students maintain equal science interest and achievement to male students in elementary school but by middle and high school they fall behind their male peers. Reasons cited for girls' declining interest in science include battling traditional gender stereotypes, lack of encouragement, and lack of female role models. Four main science concerns related to girls/women as indicated by research literature were science access, career choices, achievement, and motivation. In Georgia, some girls have made a break from the research trends by demonstrating their fervor for science through participation in the academic activity, Science Olympiad. The purpose of this study was to examine the science perceptions of girls who demonstrated science success by their participation in Science Olympiad. Utilizing phenomenological and feminist perspectives, the qualitative research method of focus group interviewing was used to address the research questions comprising the four science concerns of female science access, career choices, achievement, and motivation. The study participants were all girls/women who participated in Science Olympiad. A total of five focus groups were studied. One of the focus groups had current college undergraduates, former Science Olympians, in it while the others were composed of high school girls. Through the description of their science experiences, the participants shared their perceptions of the four science concerns. When addressing these science concerns, the participants revealed four factors that had most affected their science perceptions: the importance of support, science needs Serious Fun, teachers matter, and the bonuses of extracurricular involvement. In their experiences, the participants found success in science because they had teachers, parents, and peers who supported their academic interests, including science, and

A Science Products Inventory for Citizen-Science Planning and Evaluation.

Science.gov (United States)

Wiggins, Andrea; Bonney, Rick; LeBuhn, Gretchen; Parrish, Julia K; Weltzin, Jake F

2018-06-01

Citizen science involves a range of practices involving public participation in scientific knowledge production, but outcomes evaluation is complicated by the diversity of the goals and forms of citizen science. Publications and citations are not adequate metrics to describe citizen-science productivity. We address this gap by contributing a science products inventory (SPI) tool, iteratively developed through an expert panel and case studies, intended to support general-purpose planning and evaluation of citizen-science projects with respect to science productivity. The SPI includes a collection of items for tracking the production of science outputs and data practices, which are described and illustrated with examples. Several opportunities for further development of the initial inventory are highlighted, as well as potential for using the inventory as a tool to guide project management, funding, and research on citizen science.

A science products inventory for citizen-science planning and evaluation

Science.gov (United States)

Wiggins, Andrea; Bonney, Rick; LeBuhn, Gretchen; Parrish, Julia K.; Weltzin, Jake F.

2018-01-01

Citizen science involves a range of practices involving public participation in scientific knowledge production, but outcomes evaluation is complicated by the diversity of the goals and forms of citizen science. Publications and citations are not adequate metrics to describe citizen-science productivity. We address this gap by contributing a science products inventory (SPI) tool, iteratively developed through an expert panel and case studies, intended to support general-purpose planning and evaluation of citizen-science projects with respect to science productivity. The SPI includes a collection of items for tracking the production of science outputs and data practices, which are described and illustrated with examples. Several opportunities for further development of the initial inventory are highlighted, as well as potential for using the inventory as a tool to guide project management, funding, and research on citizen science.

A Science Products Inventory for Citizen-Science Planning and Evaluation

Science.gov (United States)

Wiggins, Andrea; Bonney, Rick; LeBuhn, Gretchen; Parrish, Julia K; Weltzin, Jake F

2018-01-01

Abstract Citizen science involves a range of practices involving public participation in scientific knowledge production, but outcomes evaluation is complicated by the diversity of the goals and forms of citizen science. Publications and citations are not adequate metrics to describe citizen-science productivity. We address this gap by contributing a science products inventory (SPI) tool, iteratively developed through an expert panel and case studies, intended to support general-purpose planning and evaluation of citizen-science projects with respect to science productivity. The SPI includes a collection of items for tracking the production of science outputs and data practices, which are described and illustrated with examples. Several opportunities for further development of the initial inventory are highlighted, as well as potential for using the inventory as a tool to guide project management, funding, and research on citizen science. PMID:29867254

Benchmarking biofuels; Biobrandstoffen benchmarken

Energy Technology Data Exchange (ETDEWEB)

Croezen, H.; Kampman, B.; Bergsma, G.

2012-03-15

A sustainability benchmark for transport biofuels has been developed and used to evaluate the various biofuels currently on the market. For comparison, electric vehicles, hydrogen vehicles and petrol/diesel vehicles were also included. A range of studies as well as growing insight are making it ever clearer that biomass-based transport fuels may have just as big a carbon footprint as fossil fuels like petrol or diesel, or even bigger. At the request of Greenpeace Netherlands, CE Delft has brought together current understanding on the sustainability of fossil fuels, biofuels and electric vehicles, with particular focus on the performance of the respective energy carriers on three sustainability criteria, with the first weighing the heaviest: (1) Greenhouse gas emissions; (2) Land use; and (3) Nutrient consumption [Dutch] Greenpeace Nederland heeft CE Delft gevraagd een duurzaamheidsmeetlat voor biobrandstoffen voor transport te ontwerpen en hierop de verschillende biobrandstoffen te scoren. Voor een vergelijk zijn ook elektrisch rijden, rijden op waterstof en rijden op benzine of diesel opgenomen. Door onderzoek en voortschrijdend inzicht blijkt steeds vaker dat transportbrandstoffen op basis van biomassa soms net zoveel of zelfs meer broeikasgassen veroorzaken dan fossiele brandstoffen als benzine en diesel. CE Delft heeft voor Greenpeace Nederland op een rijtje gezet wat de huidige inzichten zijn over de duurzaamheid van fossiele brandstoffen, biobrandstoffen en elektrisch rijden. Daarbij is gekeken naar de effecten van de brandstoffen op drie duurzaamheidscriteria, waarbij broeikasgasemissies het zwaarst wegen: (1) Broeikasgasemissies; (2) Landgebruik; en (3) Nutriëntengebruik.

Science as religion: when science becomes (too) irrational.

Science.gov (United States)

Muzur, Amir; Rinčić, Iva

2017-04-01

Science is expected to be objective: however, since practiced and produced by humans, it has to reflect human flows - prejudices, stubbornness, malice, and the tendency to be misused. No wonder an excellent scientist like John Eccles proclaimed science to be among the most personal activities he had known. By analysing a few examples from the history of science (in particular the intellectual development of Van Rensselaer Potter, the American onco-biochemist and bioethics pioneer), as well as the current trend of the evidence-based approach, the present paper will try to demonstrate that denying, distrusting, and opposing science for the sake of religion, as seen so many times in human history, has significant similarities to the overestimation of science we more often encounter in our times.

The Dissemination of Science and Science Journalism in Brazilian Universities: Analyzing Strategies that Facilitate Access to Science & Technology

Directory of Open Access Journals (Sweden)

Giuliana Batista Rodrigues de Queiroz

2016-12-01

Full Text Available This article is a mapping of Brazilian universities that maintain a structured work for Science Journalism and / or the dissemination of science. It analyses the strategies used by the top 50 Brazilian universities for including dissemination of science in their communication activities. In order to do this each institution’s website was examined for the purpose of collecting a large sample size of universities that organize and prioritize the dissemination of science and science journalism, and make their studies and projects available to the public. The dissemination of science is a priority for only 15 universities; ones that have structured science journalism programs. 11 of these universities are among the top 25 in the country which indicates that there is a direct relationship between academic quality and dissemination of science. Thus, this study lends to a deeper understanding of the field of science journalism.

Materials Science | NREL

Science.gov (United States)

microscopy and imaging science, interfacial and surface science, materials discovery, and thin-film material Science Materials Science Illustration with bottom row showing a ball-and-stick model and top row dense black band. State-of-the-art advances in materials science come from a combination of experiments

In-Service Turkish Elementary and Science Teachers' Attitudes toward Science and Science Teaching: A Sample from Usak Province

Science.gov (United States)

Turkmen, Lutfullah

2013-01-01

The purpose of this study is to reveal Turkish elementary teachers' and science teachers' attitudes toward science and science teaching. The sample of the study, 138 in-service elementary level science teachers from a province of Turkey, was selected by a clustered sampling method. The Science Teaching Attitude Scale-II was employed to measure the…

Social representations of science and gender in Science teaching

Directory of Open Access Journals (Sweden)

Bettina Heerdt

2017-09-01

Full Text Available This paper analyzes the Social Representations (SR of teachers regarding the Nature of Science (NoS, gender issues in society, Science and in the teaching context. The theoretical approach is Moscovici’s SR associated to NoS discussions, Science feminist theories and Teaching of Science. A number of twenty-two teachers were part of this research. Data were collected through the filmic record. The lexical analysis was performed using the Alceste software. Four classes were formed: NoS, Gender and women in Science, Gender and teaching context, and Gender and society. In the areas of the teachers’ education, it was not possible to find significant differences in SR. Through empirical data, the distinct argumentation of men and women is noticed. The SR of men, naturalized, discriminatory and of gender issue denial in society and Science, is more forceful than of women. It is necessary, in the initial and continued education, the problematization of gender issues in Science.

Science Standards, Science Achievement, and Attitudes about Evolution

Science.gov (United States)

Belin, Charlie M.; Kisida, Brian

2015-01-01

This article explores the relationships between (a) the quality of state science standards and student science achievement, (b) the public's belief in teaching evolution and the quality of state standards, and (c) the public's belief in teaching evolution and student science achievement. Using multiple measures, we find no evidence of a…

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Ming Kang1 2 Xiaoming Liao1 Guangfu Yin1 Xun Sun3 Xing Yin4 Lu Xie4 Jun Liu2. College of Materials Science and Engineering, Sichuan University, Chengdu 610064, China; College of Material Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China; Department of ...

Women in Science | Initiatives | Indian Academy of Sciences

Indian Academy of Sciences (India)

... Journal of Chemical Sciences · Journal of Earth System Science · Journal of ... and to suggest recommendations, the Council of the Indian Academy of Sciences ... in January 2005, to carry out recommendations made by the committee and to ... An article published in "The Guardian" on 10 best unsung female scientists.

Nature of Science or Nature of the Sciences?

Science.gov (United States)

Schizas, Dimitrios; Psillos, Dimitris; Stamou, George

2016-01-01

The present essay examines the emerging issue of domain-general versus domain-specific nature of science (NOS) understandings from a perspective that illuminates the value of domain-specific philosophies of science for the growth and development of the NOS educational field. Under the assumption that individual sciences do have their own…

Open Science: a first step towards Science Communication

Science.gov (United States)

Grigorov, Ivo; Tuddenham, Peter

2015-04-01

As Earth Science communicators gear up to adopt the new tools and captivating approaches to engage citizen scientists, budding entrepreneurs, policy makers and the public in general, researchers have the responsibility, and opportunity, to fully adopt Open Science principles and capitalize on its full societal impact and engagement. Open Science is about removing all barriers to basic research, whatever its formats, so that it can be freely used, re-used and re-hashed, thus fueling discourse and accelerating generation of innovative ideas. The concept is central to EU's Responsible Research and Innovation philosophy, and removing barriers to basic research measurably contributes to engaging citizen scientists into the research process, it sets the scene for co-creation of solutions to societal challenges, and raises the general science literacy level of the public. Despite this potential, only 50% of today's basic research is freely available. Open Science can be the first passive step of communicating marine research outside academia. Full and unrestricted access to our knowledge including data, software code and scientific publications is not just an ethical obligation, but also gives solid credibility to a more sophisticated communication strategy on engaging society. The presentation will demonstrate how Open Science perfectly compliments a coherent communication strategy for placing Marine Research in societal context, and how it underpin an effective integration of Ocean & Earth Literacy principles in standard educational, as well mobilizing citizen marine scientists, thus making marine science Open Science.

Science in Cinema. Teaching Science Fact through Science Fiction Films.

Science.gov (United States)

Dubeck, Leroy W.; And Others

Many feel that secondary school graduates are not prepared to compete in a world of rapidly expanding technology. High school and college students in the United States often prefer fantasy to science. This book offers a strategy for overcoming student apathy toward the physical sciences by harnessing the power of the cinema. In it, ten popular…

Advancing the Science of Team Science

Science.gov (United States)

Falk‐Krzesinski, Holly J.; Börner, Katy; Contractor, Noshir; Fiore, Stephen M.; Hall, Kara L.; Keyton, Joann; Spring, Bonnie; Stokols, Daniel; Trochim, William; Uzzi, Brian

2010-01-01

Abstract The First Annual International Science of Team Science (SciTS) Conference was held in Chicago, IL April 22–24, 2010. This article presents a summary of the Conference proceedings. Clin Trans Sci 2010; Volume 3: 263–266. PMID:20973925

Citizen science can improve conservation science, natural resource management, and environmental protection

Science.gov (United States)

McKinley, Duncan C.; Miller-Rushing, Abe J.; Ballard, Heidi L.; Bonney, Rick; Brown, Hutch; Cook-Patton, Susan; Evans, Daniel M.; French, Rebecca A.; Parrish, Julia; Phillips, Tina B.; Ryan, Sean F.; Shanley, Lea A.; Shirk, Jennifer L.; Stepenuck, Kristine F.; Weltzin, Jake F.; Wiggins, Andrea; Boyle, Owen D.; Briggs, Russell D.; Chapin, Stuart F.; Hewitt, David A.; Preuss, Peter W.; Soukup, Michael A.

2017-01-01

Citizen science has advanced science for hundreds of years, contributed to many peer-reviewed articles, and informed land management decisions and policies across the United States. Over the last 10 years, citizen science has grown immensely in the United States and many other countries. Here, we show how citizen science is a powerful tool for tackling many of the challenges faced in the field of conservation biology. We describe the two interwoven paths by which citizen science can improve conservation efforts, natural resource management, and environmental protection. The first path includes building scientific knowledge, while the other path involves informing policy and encouraging public action. We explore how citizen science is currently used and describe the investments needed to create a citizen science program. We find that:Citizen science already contributes substantially to many domains of science, including conservation, natural resource, and environmental science. Citizen science informs natural resource management, environmental protection, and policymaking and fosters public input and engagement.Many types of projects can benefit from citizen science, but one must be careful to match the needs for science and public involvement with the right type of citizen science project and the right method of public participation.Citizen science is a rigorous process of scientific discovery, indistinguishable from conventional science apart from the participation of volunteers. When properly designed, carried out, and evaluated, citizen science can provide sound science, efficiently generate high-quality data, and help solve problems.

Parents' and children's beliefs about science and science careers

Science.gov (United States)

Telfer, Jo Ann

Science has become an essential part of our cultural, social and technological lives. Around the world economic policies are giving high priority to the production of new knowledge generated by scientists. Unfortunately, gender equality in science-related careers has not been achieved. Women who possess high intellectual and personal abilities are succeeding in many occupational areas previously closed to all but the most impervious women, but females are still largely underrepresented in physical science and mathematics related careers. The purpose of the current study was to examine the reasons for this underrepresentation of women in science-related careers. Participants included a subset of mothers (n = 174), fathers (n = 132) and children (n = 186) from a larger study at the University of Calgary entitled Gender Differences in Student Participation and Achievement in the Sciences: Choice or Chance ? Telephone interview and survey questionnaire data were examined for gender and achievement level differences, focusing on high achieving girls who are most likely to succeed in science-related careers. Relationships between parents' and children's responses were also examined using the theoretical construct of Eccles' Model of Achievement Related Choices. Gathered data were studied using factor analysis, multivariate analysis of variance, analysis of variance as well as categorical analysis of qualitative results. Girls and boys achieved similar grades on all academic measures except the Alberta Science Achievement Test, where boys scored significantly higher than girls. Mothers, fathers, and children indicated positive attitudes towards science, no gender stereotyping about science and science careers, and gender neutral beliefs about science achievement. Gender differences were found in expressed possibility of future career choice. Science/Professional Careers were viewed as male occupations by mothers and children, but as gender neutral occupations by fathers

Experiments on chemical and physical evolution of interstellar grain mantles

International Nuclear Information System (INIS)

Greenberg, J.M.

1984-01-01

The Astrophysical Laboratory at the University of Leiden is the first to succeed in simulating the essential conditions in interstellar space as they affect the evolution of interstellar grains. (author)

Effect van volledig roostervloer en dichte vloer en doorlaatbaarheid van vloeren in varkensstallen op milieu, diergezondheid en -welzijn en voedselveiligheid: een literatuur review

NARCIS (Netherlands)

Vermeij, I.; Enting, J.; Spoolder, H.A.M.

2009-01-01

Een integrale benadering kan leiden tot het verbeteren van een vloeruitvoering. Niet alleen spleetbreedte of aandeel roostervloer is belangrijk, maar een minimum percentage doorlaatbaarheid van het totale vloeroppervlak is doorslaggevend

Science Fiction in the Political Science Classroom: A Comment

Science.gov (United States)

Landers, Clifford E.

1977-01-01

Science fiction can be used for introducing and analyzing political concepts at the undergraduate level for either a specialized theory-oriented course such as Political Science Fiction or an Introduction to Political Science course. (Author/RM)

Learning Science and the Science of Learning. Science Educators' Essay Collection.

Science.gov (United States)

Bybee, Rodger W., Ed.

This yearbook addresses critical issues in science learning and teaching. Contents are divided into four sections: (1) "How Do Students Learn Science?"; (2) "Designing Curriculum for Student Learning"; (3) "Teaching That Enhances Student Learning"; and (4) "Assessing Student Learning." Papers include: (1) "How Students Learn and How Teachers…

Midwest Science Festival: Exploring Students' and Parents' Participation in and Attitudes Toward Science.

Science.gov (United States)

Dippel, Elizabeth A; Mechels, Keegan B; Griese, Emily R; Laufmann, Rachel N; Weimer, Jill M

2016-08-01

Compared to national numbers, South Dakota has a higher proportion of students interested in science, technology, engineering, and mathematics (STEM) fields. Interest in science can be influenced by exposure to science through formal and informal learning. Informal science activities (including exposures and participation) have been found to elicit higher levels of interest in science, likely impacting one's attitude towards science overall. The current study goal is to better understand the levels and relationships of attitude, exposure, and participation in science that were present among students and parents attending a free science festival. The project collected survey data from 65 students and 79 parents attending a science festival ranging from age 6 to 65. Informal science participation is significantly related to science attitudes in students and informal science exposure is not. No relationship was found for parents between science attitudes and participation. Students who indicated high levels of informal science participation (i.e., reading science-themed books) were positively related to their attitudes regarding science. However, informal science exposures, such as attending the zoo or independently visiting a science lab, was not significantly associated with positive attitudes towards science.

Do compulsory secondary science courses change students’ attitude towards studying science?

DEFF Research Database (Denmark)

Kristensen, Lærke Elisabeth; Petersen, Morten Rask

2015-01-01

recruitment to STEM education has been a compulsory course in the Gymnasium called Natural Science Subject (NSS). This is an interdisciplinary, introductory course with the intention that students shall “ … realize the importance of knowing and understanding natural science thinking” (Authors translation...... science and science careers. In this approach we ended up with the following research question: “Does a compulsory introductory sciences course have an impact on students’ attitude towards studying sciences in secondary school?” In this approach we chose to use parameters as motivation (Deci & Ryan, 2002...... Subject course. The distribution included all levels (K10-K12) and all study lines. Student answers were analyzed using Mann-Whitney U-test using SPSS statistics 22 as analytical tool. Comparisons for this study were made across study lines (natural science vs. human science & social science...

The Presentation of Science in Everyday Life: The Science Show

Science.gov (United States)

Watermeyer, Richard

2013-01-01

This paper constitutes a case-study of the "science show" model of public engagement employed by a company of science communicators focused on the popularization of science, technology, engineering and mathematics (STEM) subject disciplines with learner constituencies. It examines the potential of the science show to foster the interest…

Turkish Pre-Service Science Teachers' Views on Science-Technology-Society Issues

Science.gov (United States)

Yalvac, Bugrahan; Tekkaya, Ceren; Cakiroglu, Jale; Kahyaoglu, Elvan

2007-01-01

The international science education community recognises the role of pre-service science teachers' views about the interdependence of Science, Technology, and Society (STS) in achieving scientific literacy for all. To this end, pre-service science teachers' STS views signal the strengths and the weaknesses of science education reform movements.…

Science Lives: Women and Minorities in the Sciences.

Science.gov (United States)

Minnesota Univ., Minneapolis. KUOM Radio.

This pamphlet and accompanying brochure of the same title describe a radio series of 13 half hour programs on the participation of women and minorities in science in the United States. The series attempts to make the public aware of the crisis in the sciences and science education and provides role models for young people, particularly young women…

Science 101: What Constitutes a Good Science Project

Science.gov (United States)

Robertson, Bill

2016-01-01

Having written columns dealing with science fairs before, Bill Robertson notes that it's been a long time since he has tackled the subject of what passes for a "science fair" in schools these days. Because science fairs have changed over the years, Robertson revisits the topic and explains the scientific method. The main focus of the…

Towards Building Science Teachers’ Understandings of Contemporary Science Practices

Directory of Open Access Journals (Sweden)

Greg Lancaster

2017-03-01

Full Text Available Faculties of Education and Science at Monash University have designed a Masters unit to assist pre-service and in-service science teachers in exploring the practices of contemporary science and examine how varied understandings can influence science communication. Teachers are encouraged to explore their current understandings of the Nature of Science (NoS and to contrast their views with those known to be widely held by society (Cobern & Loving, 1998. Teachers are challenged to provide insights into their thinking relating to the NoS. In order to build understandings of contemporary science practice each teacher shadows a research scientist and engages them in conversations intended to explore the scientists’ views of NoS and practice. Findings suggest that teachers were initially uncomfortable with the challenge to express ideas relating to their NoS and were also surprised how diverse the views of NoS can be among teachers, scientists and their peers, and that these views can directly impact ways of communicating contemporary science practice.

Constructivism in Science and Science Education: A Philosophical Critique

Science.gov (United States)

Nola, Robert

This paper argues that constructivist science education works with an unsatisfactory account of knowledge which affects both its account of the nature of science and of science education. The paper begins with a brief survey of realism and anti-realism in science and the varieties of constructivism that can be found. In the second section the important conception of knowledge and teaching that Plato develops in the Meno is contrasted with constructivism. The section ends with an account of the contribution that Vico (as understood by constructivists), Kant and Piaget have made to constructivist doctrines. Section three is devoted to a critique of the theory of knowledge and the anti-realism of von Glaserfeld. The final section considers the connection, or lack of it, between the constructivist view of science and knowledge and the teaching of science.

Global Patterns in Students' Views of Science and Interest in Science

Science.gov (United States)

van Griethuijsen, Ralf A. L. F.; van Eijck, Michiel W.; Haste, Helen; den Brok, Perry J.; Skinner, Nigel C.; Mansour, Nasser; Savran Gencer, Ayse; BouJaoude, Saouma

2015-08-01

International studies have shown that interest in science and technology among primary and secondary school students in Western European countries is low and seems to be decreasing. In many countries outside Europe, and especially in developing countries, interest in science and technology remains strong. As part of the large-scale European Union funded `Science Education for Diversity' project, a questionnaire probing potential reasons for this difference was completed by students in the UK, Netherlands, Turkey, Lebanon, India and Malaysia. This questionnaire sought information about favourite courses, extracurricular activities and views on the nature of science. Over 9,000 students aged mainly between 10 and 14 years completed the questionnaire. Results revealed that students in countries outside Western Europe showed a greater interest in school science, in careers related to science and in extracurricular activities related to science than did Western European students. Non-European students were also more likely to hold an empiricist view of the nature of science and to believe that science can solve many problems faced by the world. Multilevel analysis revealed a strong correlation between interest in science and having such a view of the Nature of Science.

Teaching Science as Science Is Practiced: Opportunities and Limits for Enhancing Preservice Elementary Teachers' Self-Efficacy for Science and Science Teaching

Science.gov (United States)

Avery, Leanne M.; Meyer, Daniel Z.

2012-01-01

Science teaching in elementary schools, or the lack thereof, continues to be an area of concern and criticism. Preservice elementary teachers' lack of confidence in teaching science is a major part of this problem. In this mixed-methods study, we report the impacts of an inquiry-based science course on preservice elementary teachers' self-efficacy…

Online citizen science games: Opportunities for the biological sciences.

Science.gov (United States)

Curtis, Vickie

2014-12-01

Recent developments in digital technologies and the rise of the Internet have created new opportunities for citizen science. One of these has been the development of online citizen science games where complex research problems have been re-imagined as online multiplayer computer games. Some of the most successful examples of these can be found within the biological sciences, for example, Foldit, Phylo and EteRNA. These games offer scientists the opportunity to crowdsource research problems, and to engage with those outside the research community. Games also enable those without a background in science to make a valid contribution to research, and may also offer opportunities for informal science learning.

Science and anti-science

CERN Document Server

Holton, Gerald

1997-01-01

What is good science? What goal--if any--is the proper end of scientific activity? Is there a legitimating authority that scientists mayclaim? Howserious athreat are the anti-science movements? These questions have long been debated but, as Gerald Holton points out, every era must offer its own responses. This book examines these questions not in the abstract but shows their historic roots and the answers emerging from the scientific and political controversies of this century. Employing the case-study method and the concept of scientific thematathat he has pioneered, Holton displays the broad scope of his insight into the workings of science: from the influence of Ernst Mach on twentiethcentury physicists, biologists, psychologists, and other thinkers to the rhetorical strategies used in the work of Albert Einstein, Niels Bohr, and others; from the bickering between Thomas Jefferson and the U.S. Congress over the proper form of federal sponsorship of scientific research to philosophical debates since Oswald...

Studying Students' Science Literacy: Non-Scientific Beliefs and Science Literacy Measures

Science.gov (United States)

Impey, C.; Buxner, S.

2015-11-01

We have been conducting a study of university students' science literacy for the past 24 years. Based on the work of the National Science Board's ongoing national survey of the US public, we have administered the same survey to undergraduate science students at the University of Arizona almost every year since 1989. Results have shown relatively little change in students' overall science literacy, descriptions of science, and knowledge of basic science topics for almost a quarter of a century despite an increase in education interventions, the rise of the internet, and increased access to knowledge. Several trends do exist in students' science literacy and descriptions of science. Students who exhibit beliefs in non-scientific phenomenon (e.g., lucky numbers, creationism) consistently have lower science literacy scores and less correct descriptions of scientific phenomenon. Although not surprising, our results support ongoing efforts to help students generate evidence based thinking.

FWP executive summaries: Basic energy sciences materials sciences programs

Energy Technology Data Exchange (ETDEWEB)

Samara, G.A.

1996-02-01

This report provides an Executive Summary of the various elements of the Materials Sciences Program which is funded by the Division of Materials Sciences, Office of Basic Energy Sciences, U.S. Department of Energy at Sandia National Laboratories, New Mexico.