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Sample records for school monterey ca

  1. 75 FR 59963 - Safety Zone: Monte Foundation Firework Display, Monterey, CA

    Science.gov (United States)

    2010-09-29

    ...-AA00 Safety Zone: Monte Foundation Firework Display, Monterey, CA AGENCY: Coast Guard, DHS. ACTION... Monte Foundation Firework Display. This safety zone is established to ensure the safety of participants... be completed. Because of the dangers posed by the pyrotechnics used in this fireworks display, the...

  2. 11th Annual Mine Warfare Technology Symposium, May 6-8, 2014 - Monterey, CA

    OpenAIRE

    2014-01-01

    The Naval Postgraduate School (NPS), the Office of Naval Research (ONR), the Program Executive Office Littoral Combat Ships (PEO LCS), OPNAV (N95), and The Consortium for Robotics and Unmanned Systems Education and Research (CRUSER) are pleased to announce the ELEVENTH International Mine Warfare Technology Symposium in Monterey, California, May 6-8, 2014.

  3. 76 FR 47237 - Notice of Realty Action: Direct Sale of Public Land in Monterey County, CA

    Science.gov (United States)

    2011-08-04

    ... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLCA9300000 L58790000 EU0000; CACA 50168-14] Notice of Realty Action: Direct Sale of Public Land in Monterey County, CA AGENCY: Bureau of Land Management, Interior. ACTION: Notice of realty action. SUMMARY: The Bureau of Land Management (BLM...

  4. 78 FR 45964 - Notice of Intent To Repatriate Cultural Items: Monterey Museum of Art, Monterey, CA

    Science.gov (United States)

    2013-07-30

    ... projectile points, 38 pendants or beads, 3 fire-starters, 4 hand tools, 6 fishing weights, 37 carvings, 1... stone. In the 1978 Deed of Gift to the Monterey Museum of Art, Mr. Holman notes that the objects were...

  5. Application of the Hyperspectral Imager for the Coastal Ocean to Phytoplankton Ecology Studies in Monterey Bay, CA, USA

    Directory of Open Access Journals (Sweden)

    John P. Ryan

    2014-01-01

    Full Text Available As a demonstrator for technologies for the next generation of ocean color sensors, the Hyperspectral Imager for the Coastal Ocean (HICO provides enhanced spatial and spectral resolution that is required to understand optically complex aquatic environments. In this study we apply HICO, along with satellite remote sensing and in situ observations, to studies of phytoplankton ecology in a dynamic coastal upwelling environment—Monterey Bay, CA, USA. From a spring 2011 study, we examine HICO-detected spatial patterns in phytoplankton optical properties along an environmental gradient defined by upwelling flow patterns and along a temporal gradient of upwelling intensification. From a fall 2011 study, we use HICO’s enhanced spatial and spectral resolution to distinguish a small-scale “red tide” bloom, and we examine bloom expansion and its supporting processes using other remote sensing and in situ data. From a spectacular HICO image of the Monterey Bay region acquired during fall of 2012, we present a suite of algorithm results for characterization of phytoplankton, and we examine the strengths, limitations, and distinctions of each algorithm in the context of the enhanced spatial and spectral resolution.

  6. Correction: Ryan, J., et al. Application of the Hyperspectral Imager for the Coastal Ocean to Phytoplankton Ecology Studies in Monterey Bay, CA, USA. Remote Sens. 2014, 6, 1007–1025

    Directory of Open Access Journals (Sweden)

    Marcos J. Montes

    2015-10-01

    Full Text Available Studies of phytoplankton ecology in Monterey Bay, CA, USA, using the Hyperspectral Imager for the Coastal Ocean (HICO and other satellite remote sensing and in-situ observations, were presented in [1]. [...

  7. Southern Monterey Bay Littoral Cell CRSMP CEMEX Mine Dredge Pond 2008

    Data.gov (United States)

    California Natural Resource Agency — Location of the CEMEX mine dredge pond at Lapis Sand Plant, Marina, CA. Southern Monterey Bay has been the most intensively mined shoreline in the U.S. Sand mining...

  8. Study of Integrated USV/UUV Observation System Performance in Monterey Bay

    Science.gov (United States)

    2017-09-01

    EMATT expendable mobile ASW training target MARS Monterey Accelerated Research System MBARI Monterey Bay Aquarium Research Institute PSD power ...Paula Travis, provided needed support as well. The Naval Postgraduate School faculty and staff are incredibly professional and knowledgeable . The...operation. 9 “The MARS observatory ‘science node’ (shown in orange) has eight ports, each of which can supply data and power connections for

  9. Carbon transport in Monterey Submarine Canyon

    Science.gov (United States)

    Barry, J.; Paull, C. K.; Xu, J. P.; Clare, M. A.; Gales, J. A.; Buck, K. R.; Lovera, C.; Gwiazda, R.; Maier, K. L.; McGann, M.; Parsons, D. R.; Simmons, S.; Rosenberger, K. J.; Talling, P. J.

    2017-12-01

    Submarine canyons are important conduits for sediment transport from continental margins to the abyss, but the rate, volume, and time scales of material transport have been measured only rarely. Using moorings with current meters, sediment traps (10 m above bottom) and optical backscatter sensors, we measured near-bottom currents, suspended sediment concentrations, and sediment properties at 1300 m depth in Monterey Canyon and at a non-canyon location on the continental slope at the same depth. Flow and water column backscatter were used to characterize "ambient" conditions when tidal currents dominated the flow field, and occasional "sediment transport events" when anomalously high down-canyon flow with sediment-laden waters arrived at the canyon mooring. The ambient sediment flux measured in sediment traps in Monterey Canyon was 350 times greater than measured at the non-canyon location. Although the organic carbon content of the canyon sediment flux during ambient periods was low (1.8 %C) compared to the slope location (4.9 %C), the ambient carbon transport in the canyon was 130 times greater than at the non-canyon site. Material fluxes during sediment transport events were difficult to measure owing to clogging of sediment traps, but minimal estimates indicate that mass transport during events exceeds ambient sediment fluxes through the canyon by nearly 3 orders of magnitude, while carbon transport is 380 times greater. Estimates of the instantaneous and cumulative flux of sediment and carbon from currents, backscatter, and sediment properties indicated that: 1) net flux is down-canyon, 2) flux is dominated by sediment transport events, and 3) organic carbon flux through 1300 m in Monterey Canyon was ca. 1500 MT C per year. The injection of 1500 MTCy-1 into the deep-sea represents ca. 260 km2 of the sediment C flux measured at the continental slope station (5.8 gCm-2y-1) and is sufficient to support a benthic community carbon demand of 5 gCm-2y-1 over 300 km2.

  10. Monterey MRWPCA Interceptor Pipeline 2008

    Data.gov (United States)

    California Natural Resource Agency — The Monterey Interceptor between Seaside Pump Station and Monterey Beach Resort is buried in the dunes, approximately 100 to 175 feet from the dune bluff. Between...

  11. Monterey MRWPCA Interceptor Pipeline 2008

    Data.gov (United States)

    California Department of Resources — The Monterey Interceptor between Seaside Pump Station and Monterey Beach Resort is buried in the dunes, approximately 100 to 175 feet from the dune bluff. Between...

  12. 77 FR 57562 - Meeting of the Board of Advisors to The Presidents of the Naval Postgraduate School and the Naval...

    Science.gov (United States)

    2012-09-18

    ... defense guidance and its implication for the military and Joint Professional Military Education... School, 1 University Circle, Monterey, CA 93943-5001 or by fax 831-656-3145 by September 15, 2012. Dated...

  13. COMBATXXI, JDAFS, and LBC Integration Requirements for EASE

    Science.gov (United States)

    2015-10-06

    AND ADDRESS(ES) TRADOC Analysis Center, Monterey, CA Naval Postgraduate School , Monterey, CA 8. PERFORMING ORGANIZATION REPORT NUMBER 9...COMBATXXI Process Flow Diagram from.11 JDAFS JDAFS is an entity-level combat simulation model developed at Naval Postgraduate School and TRAC...of the shipment; can be “ANY” . destination String The name of the destination of the shipment; cane be “ANY”. probability double The probability

  14. California State Waters Map Series—Monterey Canyon and vicinity, California

    Science.gov (United States)

    Dartnell, Peter; Maier, Katherine L.; Erdey, Mercedes D.; Dieter, Bryan E.; Golden, Nadine E.; Johnson, Samuel Y.; Hartwell, Stephen R.; Cochrane, Guy R.; Ritchie, Andrew C.; Finlayson, David P.; Kvitek, Rikk G.; Sliter, Ray W.; Greene, H. Gary; Davenport, Clifton W.; Endris, Charles A.; Krigsman, Lisa M.; Dartnell, Peter; Cochran, Susan A.

    2016-06-10

    IntroductionIn 2007, the California Ocean Protection Council initiated the California Seafloor Mapping Program (CSMP), designed to create a comprehensive seafloor map of high-resolution bathymetry, marine benthic habitats, and geology within the 3-nautical-mile limit of California’s State Waters. The CSMP approach is to create highly detailed seafloor maps through collection, integration, interpretation, and visualization of swath bathymetry data, acoustic backscatter, seafloor video, seafloor photography, high-resolution seismic-reflection profiles, and bottom-sediment sampling data. The map products display seafloor morphology and character, identify potential marine benthic habitats, and illustrate both the surficial seafloor geology and shallow subsurface geology.The Monterey Canyon and Vicinity map area lies within Monterey Bay in central California. Monterey Bay is one of the largest embayments along the west coast of the United States, spanning 36 km from its northern to southern tips (in Santa Cruz and Monterey, respectively) and 20 km along its central axis. Not only does it contain one of the broadest sections of continental shelf along California’s coast, it also contains Monterey Canyon, one of the largest and deepest submarine canyons in the world. Note that the California’s State Waters limit extends farther offshore between Santa Cruz and Monterey so that it encompasses all of Monterey Bay.The coastal area within the map area is lightly populated. The community of Moss Landing (population, 204) hosts the largest commercial fishing fleet in Monterey Bay in its harbor. The map area also includes parts of the cities of Marina (population, about 20,000) and Castroville (population, about 6,500). Fertile lowlands of the Salinas River and Pajaro River valleys largely occupy the inland part of the map area, and land use is primarily agricultural.The offshore part of the map area lies completely within the Monterey Bay National Marine Sanctuary. The

  15. The morphology, processes, and evolution of Monterey Fan: a revisit

    Science.gov (United States)

    Gardner, James V.; Bohannon, Robert G.; Field, Michael E.; Masson, Douglas G.

    2010-01-01

    Long-range (GLORIA) and mid-range (TOBI) sidescan imagery and seismic-reflection profiles have revealed the surface morphology and architecture of the complete Monterey Fan. The fan has not developed a classic wedge shape because it has been blocked for much of its history by Morro Fracture Zone. The barrier has caused the fan to develop an upper-fan and lower-fan sequence that are distinctly different from one another. The upper-fan sequence is characterized by Monterey and Ascension Channels and associated Monterey Channel-levee system. The lower-fan sequence is characterized by depositional lobes of the Ascension, Monterey, and Sur-Parkington-Lucia systems, with the Monterey depositional lobe being the youngest. Presently, the Monterey depositional lobe is being downcut because the system has reached a new, lower base level in the Murray Fracture Zone. A five-step evolution of Monterey Fan is presented, starting with initial fan deposition in the Late Miocene, about 5.5 Ma. This first stage was one of filling bathymetric lows in the oceanic basement in what was to become the upper-fan segment. The second stage involved filling the bathymetric low on the north side of Morro Fracture Zone, and probably not much sediment was transported beyond the fracture zone. The third stage witnessed sediment being transported around both ends of Morro Fracture Zone and initial sedimentation on the lower-fan segment. During the fourth stage Ascension Channel was diverted into Monterey Channel, thereby cutting off sedimentation to the Ascension depositional lobe.

  16. Two Missions, One Secret Service: The Value of the Investigative Mission

    Science.gov (United States)

    2011-09-01

    even the business world. After the shooting at Columbine High School in Colorado in 1999, the USSS partnered with the U.S. Department of Education to...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited TWO MISSIONS, ONE...AUTHOR(S) Richard Harlow 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School Monterey, CA 93943-5000 8. PERFORMING

  17. The Economy of Romania: How it Compares to Other Centrally-Planned Economies in Eastern Europe.

    Science.gov (United States)

    1984-06-01

    moonlighting ," with all the positive connotations of supplementing one’s in- come through industry and initiative. It is a broader, more pervasive...Western Stereotypes ." Christian Science Monitor. March 24, 1983, p. 13. Keefe, Eugene K., Violeta 0. Baluyut, William Giloane, Anne K. Long, James M. Moore...Postgraduate School Monterey, CA 93943 8. Marine Corps Representative, Code 0309 Naval Postgraduate School Monterey, CA 93940 9. Captain Grace M. Charney P.O. Box 7267 APO NY 09012 182 . . . . - FILMED 4-85 * DTIC

  18. Cost Benefit Analysis of the Monterey Pines Golf Course

    National Research Council Canada - National Science Library

    Zielinski, Matthew

    2000-01-01

    ..., the government-operated course in the Monterey area. The main purpose of this thesis is to examine the costs and benefits of having a government-operated course in Monterey, where the golf market is extremely competitive, and to examine alternatives...

  19. Canes Implementation: Analysis of Budgetary, Business, and Policy Challenges

    Science.gov (United States)

    2014-12-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT CANES IMPLEMENTATION: ANALYSIS OF BUDGETARY, BUSINESS...REPORT TYPE AND DATES COVERED December 2014 MBA Professional Rep01t 4. TITLE AND SUBTITLE 5. FUNDING NUMBERS CANES IMPLEMENTATION: ANALYSIS OF...PERFORMING ORGANIZATION Naval Postgraduate School REPORT NUMBER Monterey, CA 93943-5000 9. SPONSORING /MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10

  20. Pesticide occurrence and distribution in fog collected near Monterey, California

    Energy Technology Data Exchange (ETDEWEB)

    Schomburg, C.J.; Glotfelty, D.E. (Department of Agriculture, Beltsville, MD (USA)); Seiber, J.N. (Univ. of California, Davis (USA))

    1991-01-01

    The authors analyzed pesticides in air and fog in several fog events sampled near Monterey, CA, to determine whether the uptake of pesticides in advected oceanic fog was different from uptake in fog forming under stagnant inversion conditions in California's Central Valley in the winter. Data for several pesticides common to both ares showed that the pesticide content and distribution were remarkable similar in the two locations. The conversion of organophosphorus insecticides to their corresponding oxons, and aqueous-phase enrichment factors, were also very similar. Evidence is presented to support the hypothesis that enhanced pesticide concentration in fogwater is caused by strongly sorptive nonfilterable particles and colloids in the fog liquid that are derived from atmospheric particles.

  1. Deep-sea faunal communities associated with a lost intermodal shipping container in the Monterey Bay National Marine Sanctuary, CA.

    Science.gov (United States)

    Taylor, Josi R; DeVogelaere, Andrew P; Burton, Erica J; Frey, Oren; Lundsten, Lonny; Kuhnz, Linda A; Whaling, P J; Lovera, Christopher; Buck, Kurt R; Barry, James P

    2014-06-15

    Carrying assorted cargo and covered with paints of varying toxicity, lost intermodal containers may take centuries to degrade on the deep seafloor. In June 2004, scientists from Monterey Bay Aquarium Research Institute (MBARI) discovered a recently lost container during a Remotely Operated Vehicle (ROV) dive on a sediment-covered seabed at 1281 m depth in Monterey Bay National Marine Sanctuary (MBNMS). The site was revisited by ROV in March 2011. Analyses of sediment samples and high-definition video indicate that faunal assemblages on the container's exterior and the seabed within 10 m of the container differed significantly from those up to 500 m. The container surface provides hard substratum for colonization by taxa typically found in rocky habitats. However, some key taxa that dominate rocky areas were absent or rare on the container, perhaps related to its potential toxicity or limited time for colonization and growth. Ecological effects appear to be restricted to the container surface and the benthos within ∼10 m. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

  2. Why Do Model Tropical Cyclones Intensify More Rapidly at Low Latitudes?

    Science.gov (United States)

    2015-05-01

    University of Munich, Munich, Germany MICHAEL T. MONTGOMERY Department of Meteorology, Naval Postgraduate School , Monterey, California (Manuscript...WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School ,Department of Meteorology,Monterey,CA,93943 8...Roy.Meteor. Soc., 135, 839–850, doi:10.1002/qj.390. Willoughby, H. E., 1979: Forced secondary circulations in hurri- canes . J. Geophys. Res., 84, 3173

  3. Silent Warning: Understanding the National Terrorism Advisory System

    Science.gov (United States)

    2014-12-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited SILENT WARNING...PERFORMING OR GANIZATION NA:i\\ti E (S) AND ADDRESS(ES) Naval Postgraduate School Monterey, CA 93943-5000 9. SP ONSORING /MONIT ORING AGENCY NAME(S) AND...Homeland Sectu’ity Advisory System, Boston Marathon bombing, Christmas Day bomber, tmderwear bomber, hum cane , cotmteiteiTO!’ism, CT AB

  4. Analysis of Civilian Employee Attrition at the Naval Postgraduate School and Naval Support Activity - Monterey Bay

    National Research Council Canada - National Science Library

    Valverde, Xavier

    1997-01-01

    ...) and Naval Support Activity-Monterey Bay (NSA-MB) to determine what civilian non-faculty employee jobs are likely to be left vacant in the next three years due to attrition and to identify what training and skills will be needed by personnel whose...

  5. Evaluating the Addition of a Dinoflagellate Phytoplankton Functional Type Using Radiance Anomalies for Monterey Bay, CA

    Science.gov (United States)

    Houskeeper, H. F.; Kudela, R. M.

    2016-12-01

    Ocean color sensors have enabled daily, global monitoring of phytoplankton productivity in the world's oceans. However, to observe key structures such as food webs, or to identify regime shifts of dominant species, tools capable of distinguishing between phytoplankton functional types using satellite remote sensing reflectance are necessary. One such tool developed by Alvain et al. (2005), PHYSAT, successfully linked four phytoplankton functional types to chlorophyll-normalized remote sensing spectra, or radiance anomalies, in case-1 waters. Yet this tool was unable to characterize dinoflagellates because of their ubiquitous background presence in the open ocean. We employ a radiance anomaly technique based on PHYSAT to target phytoplankton functional types in Monterey Bay, a region where dinoflagellate populations are larger and more variable than in open ocean waters, and thus where they may be viable targets for satellite remote sensing characterization. We compare with an existing Santa Cruz Wharf photo-pigment time series spanning from 2006 to the present to regionally ground-truth the method's predictions, and we assess its accuracy in characterizing dinoflagellates, a phytoplankton group that impacts the region's fish stocks and water quality. For example, an increase in dinoflagellate abundance beginning in 2005 led to declines in commercially important fish stocks that persisted throughout the following year. Certain species of dinoflagellates in Monterey Bay are also responsible for some of the harmful algal bloom events that negatively impact the shellfish industry. Moving toward better tools to characterize phytoplankton blooms is important for understanding ecosystem shifts, as well as protecting human health in the surrounding areas.

  6. Comparison of Monterey pine stress in urban and natural forests

    Science.gov (United States)

    David J. Nowak; Joe R. McBride

    1991-01-01

    Monterey pine street trees within Carmel, California and its immediate vicinity, as well as forest-grown Monterey pine within adjacent natural stands, were sampled with regard to visual stress characteristics, and various environmental and biological variables. Two stress indices were computed, one hypothesized before data collection was based on relative foliage...

  7. Putting to Rest WISHE-ful Misconceptions for Tropical Cyclone Intensification

    Science.gov (United States)

    2014-11-27

    Persing1, and Roger K. Smith2 1Department of Meteorology, Naval Postgraduate School , Monterey, California, USA, 2Meteorological Institute, Ludwig...NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School ,Department of Meteorology,Monterey,CA,93943...paper presented at 29th Conference on Hurri- canes and Tropical Meteorology, p. 8C.7, Amer. Meteorol. Soc., Tucson, Ariz. Figure 7. Azimuthally-averaged

  8. California State Waters Map Series—Offshore of Monterey, California

    Science.gov (United States)

    Johnson, Samuel Y.; Dartnell, Peter; Hartwell, Stephen R.; Cochrane, Guy R.; Golden, Nadine E.; Watt, Janet T.; Davenport, Clifton W.; Kvitek, Rikk G.; Erdey, Mercedes D.; Krigsman, Lisa M.; Sliter, Ray W.; Maier, Katherine L.; Johnson, Samuel Y.; Cochran, Susan A.

    2016-08-18

    IntroductionIn 2007, the California Ocean Protection Council initiated the California Seafloor Mapping Program (CSMP), designed to create a comprehensive seafloor map of high-resolution bathymetry, marine benthic habitats, and geology within the 3-nautical-mile limit of California’s State Waters. The CSMP approach is to create highly detailed seafloor maps through collection, integration, interpretation, and visualization of swath bathymetry data, acoustic backscatter, seafloor video, seafloor photography, high-resolution seismic-reflection profiles, and bottom-sediment sampling data. The map products display seafloor morphology and character, identify potential marine benthic habitats, and illustrate both the surficial seafloor geology and shallow subsurface geology.The Offshore of Monterey map area in central California is located on the Pacific Coast, about 120 km south of San Francisco. Incorporated cities in the map area include Seaside, Monterey, Marina, Pacific Grove, Carmel-by-the-Sea, and Sand City. The local economy receives significant resources from tourism, as well as from the Federal Government. Tourist attractions include the Monterey Bay Aquarium, Cannery Row, Fisherman’s Wharf, and the many golf courses near Pebble Beach, and the area serves as a gateway to the spectacular scenery and outdoor activities along the Big Sur coast to the south. Federal facilities include the Army’s Defense Language Institute, the Naval Postgraduate School, and the Fleet Numerical Meteorology and Oceanography Center (operated by the Navy). In 1994, Fort Ord army base, located between Seaside and Marina, was closed; much of former army base land now makes up the Fort Ord National Monument, managed by the U.S. Bureau of Land Management as part of the National Landscape Conservation System. In addition, part of the old Fort Ord is now occupied by California State University, Monterey Bay.The offshore part of the map area lies entirely within the Monterey Bay National

  9. Total Ownership Cost Reduction Case Study: AEGIS Radar Phase Shifters

    National Research Council Canada - National Science Library

    Bridger, Wray W; Ruiz, Mark D

    2006-01-01

    ...., consolidated purchasing, lean and six sigma, productivity improvement projects, etc. This case study was conducted with the sponsorship and assistance of the Acquisition Research Program, Graduate School of Business and Public Policy, Naval Postgraduate School, Monterey, CA.

  10. Velocity and Attenuation Profiles in the Monterey Deep-Sea Fan

    Science.gov (United States)

    1987-12-01

    a. 11 o n i n and depth. Sol ’^ a 11 e i"i u a 11 o >) a i::> 1 n Ci sediment for each of the f i...i. n c t ion o f f r e q u e n c; y...estimate of sea floor depth was obtained from an oceano - graphic map of the Monterey fan (’Oceanographic Data of the Monterey Deep Sea Fan’, 1st

  11. The last 1000 years of ocean change in Monterey Bay, California: insights from the marine sedimentary record

    Science.gov (United States)

    Schwartz, V.; Addison, J. A.; Carlin, J.; Wagner, A. J.; Barron, J. A.

    2017-12-01

    In Monterey Bay, seasonal upwelling of cold nutrient-rich waters from the California Current sustains a diverse and abundant marine phytoplankton community, serving as the base of the local marine ecosystem, and contributing to atmospheric CO2 fixation. The response of this productive area to future climate change remains uncertain, thus this study looks to examine the Monterey Bay sediment record over the last millennia to provide perspective on future changes. To accomplish this, we examined biogenic sediment as a proxy for upwelling. While there is no existing sea surface temperature (SST) record for this time frame in Monterey Bay as an independent proxy of upwelling, we compare our data against the Santa Barbara Basin (SBB) alkenone SST record, and the global PAGES Ocean2K SST synthesis products to examine variability associated with the Medieval Climate Anomaly (MCA), the Little Ice Age (LIA), and the recent onset of industrial-era warming. Utilizing a pair of newly acquired sediment cores from the southern nearshore sector of Monterey Bay, PS1410-08GC (36.42°N, 121.54°W, depth 85 m) and PS1410-09GC (36.46°N, 121.51°W, depth 71 m), we performed sedimentological and geochemical analyses including multi-sensor core logging, computerized tomography (CT) scans, X-ray fluorescence (XRF), biogenic silica (opal), and HCNS elemental analysis. Age control for each core was determined by linearly interpolating basal 14C dates, and both sites represent high sedimentation rate areas (PS1410-08GC: 0.75 mm/yr, PS1410-09GC: 1.2 mm/yr). Despite being from a highly productive region, both cores contain relatively low concentrations of TOC, opal, and CaCO3, with total mean biogenic fractions of 7.38% and 6.67% for PS1410-08GC and -09GC, respectively, indicating significant terrigenous input throughout both records. Both cores show a decrease in bulk density and an increase in biogenic material from the MCA into the LIA at 1500 CE. A sharp increase in Monterey Bay bulk

  12. Monterey, California Tsunami Forecast Grids for MOST Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Monterey, California Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST) model....

  13. THE RESPONSE OF MONTEREY BAY TO THE GREAT TOHOKU EARTHQUAKE OF 2011

    Directory of Open Access Journals (Sweden)

    D. Carroll

    2011-01-01

    Full Text Available The response of Monterey Bay to the Great Tohoku earthquake of 2011 is examined in this study. From a practical standpoint, although the resulting tsunami did not cause any damage to the open harbors at Monterey and Moss Landing, it caused extensive damage to boats and infrastructure in Santa Cruz Harbor, which is closed to surrounding waters. From a scientific standpoint, the observed and predicted amplitudes of the tsunami at 1 km from the source were 21.3 and 22.5 m based on the primary arrival from one DART bottom pressure recorder located 986 km ENE of the epicenter. The predicted and observed travel times for the tsunami to reach Monterey Bay agreed within 3%. The predicted and observed periods of the tsunami-generated wave before it entered the bay yielded periods that approached 2 hours. Once the tsunami entered Monterey Bay it was transformed into a seiche with a primary period of 36-37 minutes, corresponding to quarter-wave resonance within the bay. Finally, from a predictive standpoint, major tsunamis that enter the bay from the northwest, as in the present case, are the ones most likely to cause damage to Santa Cruz harbor.

  14. THE RESPONSE OF MONTEREY BAY TO THE 2010 CHILEAN EARTHQUAKE

    Directory of Open Access Journals (Sweden)

    Laurence C. Breaker

    2011-01-01

    Full Text Available The primary frequencies contained in the arrival sequence produced by the tsunami from the Chilean earthquake of 2010 in Monterey Bay were extracted to determine the seiche modes that were produced. Singular Spectrum Analysis (SSA and Ensemble Empirical Mode Decomposition (EEMD were employed to extract the primary frequencies of interest. The wave train from the Chilean tsunami lasted for at least four days due to multipath arrivals that may not have included reflections from outside the bay but most likely did include secondary undulations, and energy trapping in the form of edge waves, inside the bay. The SSA decomposition resolved oscillations with periods of 52-57, 34-35, 26-27, and 21-22 minutes, all frequencies that have been predicted and/or observed in previous studies. The EEMD decomposition detected oscillations with periods of 50-55 and 21-22 minutes. Periods in the range of 50-57 minutes varied due to measurement uncertainties but almost certainly correspond to the first longitudinal mode of oscillation for Monterey Bay, periods of 34-35 minutes correspond to the first transverse mode of oscillation that assumes a nodal line across the entrance of the bay, a period of 26- 27 minutes, although previously observed, may not represent a fundamental oscillation, and a period of 21-22 minutes has been predicted and observed previously. A period of ~37 minutes, close to the period of 34-35 minutes, was generated by the Great Alaskan Earthquake of 1964 in Monterey Bay and most likely represents the same mode of oscillation. The tsunamis associated with the Great Alaskan Earthquake and the Chilean Earthquake both entered Monterey Bay but initially arrived outside the bay from opposite directions. Unlike the Great Alaskan Earthquake, however, which excited only one resonant mode inside the bay, the Chilean Earthquake excited several modes suggesting that the asymmetric shape of the entrance to Monterey Bay was an important factor and that the

  15. Moral Action in Everyday Life: An Ethics Process to Foster Interest & Determination in the Workplace

    OpenAIRE

    Sekerka, Leslie E.

    2006-01-01

    Business Ethics in a Global World: China, India, and Beyond - Santa Clara University -March 10, 2006 - Leslie E. Sekerka, Ph.D.Assistant Professor, Organizational Behavior & EthicsNaval Postgraduate School Monterey, CA

  16. Diagenetic Microcrystalline Opal Varieties from the Monterey Formation, CA: HRTEM Study of Structures and Phase Transformation Mechanisms

    Science.gov (United States)

    Cady, Sherry L.; Wenk, H.-R.; DeVincenzi, Don (Technical Monitor)

    1994-01-01

    Microcrystalline opal varieties form as intermediary precipitates during the diagenetic transformation of biogenically precipitated non-crystalline opal (opal-A) to microquartz. With regard to the Monterey Formation of California, X-ray powder diffraction studies have shown that a decrease in the primary d-spacing of opal-CT toward that of cristobalite occurs with increasing diagenesis. The initial timing of opal-CT/quartz formation and the value of the primary opal-CT d-spacing, are influenced by the sediment. lithology. Transmission electron microscopy methods (CTEM/HRTEM) were used to investigate the structure of the diagenetic phases and establish transformation mechanisms between the varieties of microcrystalline opals in charts and porcelanites from the Monterey Formation. HRTEM images revealed that the most common fibrous varieties of microcrystalline opals contain varying amounts of structural disorder. Finite lamellar units of cristobalite-and tridymite-type. layer sequences were found to be randomly stacked in a direction perpendicular to the fiber axis. Disordered and ordered fibers were found to have coprecipitated within the same radial fiber bundles that formed within the matrix of the Most siliceous samples. HRTEM images, which reveal that the fibers within radial and lepispheric fiber bundles branch non-crystallographically, support an earlier proposal that microspheres in chert grow via a spherulitic growth mechanism. A less common variety of opal-CT was found to be characterized by non-parallel (low-angle) stacking sequences that often contain twinned lamellae. Tabular-shaped crystals of orthorhombic tridymite (PO-2) were also identified in the porcelanite samples. A shift in the primary d-spacing of opal-CT has been interpreted as an indication of solid-state ordering g toward a predominantly cristobalite structure, (opal-C). Domains of opal-C were identified as topotactically-oriented overgrowths on discrete Sections of opal-CT fibers and as

  17. A Dictionary of Acquisition and Contracting Terms

    National Research Council Canada - National Science Library

    Colyer, Timothy

    1997-01-01

    This thesis is part of a joint research project between stndents of the Naval Postgraduate School in Monterey, CA and the Air Force Institute of Technology, Wright- Patterson Air Force Base, Dayton, OH...

  18. Multi-scale responses of scattering layers to environmental variability in Monterey Bay, California

    Science.gov (United States)

    Urmy, Samuel S.; Horne, John K.

    2016-07-01

    A 38 kHz upward-facing echosounder was deployed on the seafloor at a depth of 875 m in Monterey Bay, CA, USA (36° 42.748‧N, 122° 11.214‧W) from 27 February 2009 to 18 August 2010. This 18-month record of acoustic backscatter was compared to oceanographic time series from a nearby data buoy to investigate the responses of animals in sound-scattering layers to oceanic variability at seasonal and sub-seasonal time scales. Pelagic animals, as measured by acoustic backscatter, moved higher in the water column and decreased in abundance during spring upwelling, attributed to avoidance of a shoaling oxycline and advection offshore. Seasonal changes were most evident in a non-migrating scattering layer near 500 m depth that disappeared in spring and reappeared in summer, building to a seasonal maximum in fall. At sub-seasonal time scales, similar responses were observed after individual upwelling events, though they were much weaker than the seasonal relationship. Correlations of acoustic backscatter with oceanographic variability also differed with depth. Backscatter in the upper water column decreased immediately following upwelling, then increased approximately 20 days later. Similar correlations existed deeper in the water column, but at increasing lags, suggesting that near-surface productivity propagated down the water column at 10-15 m d-1, consistent with sinking speeds of marine snow measured in Monterey Bay. Sub-seasonal variability in backscatter was best correlated with sea-surface height, suggesting that passive physical transport was most important at these time scales.

  19. 15 CFR Appendix A to Subpart M of... - Monterey Bay National Marine Sanctuary Boundary Coordinates

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Monterey Bay National Marine Sanctuary... OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT NATIONAL MARINE SANCTUARY PROGRAM REGULATIONS Monterey Bay National Marine Sanctuary Pt. 922, Subpt. M, App. A Appendix A to Subpart M of Part 922...

  20. Southern Monterey Bay Littoral Cell CRSMP Sensitive Habitat 2008

    Data.gov (United States)

    California Natural Resource Agency — One of the most important functions of the southern Monterey Bay coastal system is its role as a habitat for a unique flora and fauna. The beaches are habitat for...

  1. Southern Monterey Bay Littoral Cell CRSMP Sensitive Habitat 2008

    Data.gov (United States)

    California Department of Resources — One of the most important functions of the southern Monterey Bay coastal system is its role as a habitat for a unique flora and fauna. The beaches are habitat for...

  2. K-12 Schools: The Effect of Public School Choices on Marine Families’ Co-Location Decisions

    Science.gov (United States)

    2017-03-01

    3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE K-12 SCHOOLS: THE EFFECT OF PUBLIC SCHOOL CHOICES ON MARINE FAMILIES’ CO...be educated ? One theory regarding decision-making in general is the rational choice theory . This approach to explaining the process of making...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. K-12 SCHOOLS

  3. Fe-Ca-phosphate, Fe-silicate, and Mn-oxide minerals in concretions from the Monterey Formation

    Science.gov (United States)

    Medrano, M.D.; Piper, D.Z.

    1997-01-01

    Concentrically zoned phosphatic-enriched concretions were collected at three sites from the Monterey Formation. The following minerals were identified: vivianite, lipscombite, rockbridgeite, leucophosphite, mitridatite, carbonate fluorapatite, nontronite, todorokite, and barite. The mineralogy of the concretions was slightly different at each of the three collection sites. None of the concretions contains all of the minerals, but the spatial distribution of minerals in individual concretions, overlapping mineralogies between different concretions, and the geochemical properties of the separate minerals suggest a paragenesis represented by the above order. Eh increased from the precipitation of vivianite to that of rockbridgeite/lipscombite. The precipitation of leucophosphite, then mitridatite, carbonate fluorapatite and todorokite/Fe-oxide indicates increasing pH. Concretion growth culminated with the precipitation of todorokite, a Mn oxide, and minor amounts of barite along microfractures. Conspicuously absent are Fe-sulfide and Mn-phosphate minerals. The concretions are hosted by finely laminated diatomite. The laminations exhibit little to no deformation around the concretions, requiring that the concretions formed after compaction. We interpret this sediment feature and the paragenesis as recording the evolving pore-water chemistry as the formation was uplifted into the fresh-ground-water zone.

  4. The evolving fresh market berry industry in Santa Cruz and Monterey counties

    Directory of Open Access Journals (Sweden)

    Laura Tourte

    2016-08-01

    Full Text Available The fresh market berry industry in Santa Cruz and Monterey counties has contributed significantly to the agricultural vibrancy of the two counties and the state of California. Dramatic growth in strawberry, raspberry and blackberry production has been documented over the last 50 years, and most notably since the 1980s. Factors influencing this growth include innovations in agricultural practices and heightened consumer demand. Here, we review the historical context for the berry industry in Santa Cruz and Monterey counties. Organic production, production economics and challenges for the future are also discussed.

  5. Southern Monterey Bay Littoral Cell CRSMP Critical Erosion Sites 2008

    Data.gov (United States)

    California Natural Resource Agency — PWA and Griggs (2004) defined three risk categories to Monterey Regional Water Pollution Control Agency (MRWPCA) facilities between Marina and Wharf II. These risk...

  6. Southern Monterey Bay Littoral Cell CRSMP Critical Erosion Sites 2008

    Data.gov (United States)

    California Department of Resources — PWA and Griggs (2004) defined three risk categories to Monterey Regional Water Pollution Control Agency (MRWPCA) facilities between Marina and Wharf II. These risk...

  7. Identification of a new marine algal species Pyropia nitida sp. nov. (Bangiales: Rhodophyta) from Monterey, California.

    Science.gov (United States)

    Harden, Leeanne K; Morales, Karina M; Hughey, Jeffery R

    2016-07-01

    An unidentified marine red algal species classified in Pyropia J. Agardh was discovered from Monterey, CA. Morphological, barcode, and complete mitochondrial genome analysis of the alga support its recognition as a new species, Pyropia nitida sp. nov. The species is a high-intertidal, winter annual that is lanceolate in shape, monostromatic, and dioecious. Based on CO1 sequences, P. nitida is closely allied with the P. nereocystis clade. The mitogenome of P. nitida is 35 313 bp in length and contains 53 genes, including two ribosomal RNAs, 24 transfer RNAs, four ribosomal proteins, two ymfs, four ORFs, and 17 genes involved in electron transport and oxidative phosphorylation. The results support the recognition of P. nitida as distinct from the morphologically similar P. lanceolata.

  8. Southern Monterey Bay Littoral Cell CRSMP Proposed Receiver Site 2008

    Data.gov (United States)

    California Natural Resource Agency — Given the location of the critical areas of erosion and the need to avoid adverse impacts to local sensitive habitat, the Southern Monterey Bay Coastal RSM Plan...

  9. Southern Monterey Bay Littoral Cell CRSMP Proposed Receiver Site 2008

    Data.gov (United States)

    California Department of Resources — Given the location of the critical areas of erosion and the need to avoid adverse impacts to local sensitive habitat, the Southern Monterey Bay Coastal RSM Plan...

  10. Monterey Bay Aquarium Volunteer Guide Scheduling Analysis

    Science.gov (United States)

    2014-12-01

    TERMS 15. NUMBER OF Monterey Bay Aquarium, linear programing, network design, multi commodity flow, resilience PAGES 17. SECURITY 18. SECURITY...Volunteers fill many roles that include Aquarium guides, information desk attendants, divers, and animal caregivers . Julie Packard, Executive Director of...further analyze the resiliency of the shifts to changes in staffing levels caused by no-shows or drop-ins. 3 While the guide program managers have

  11. monterey_ca.grd

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NGDC builds and distributes high-resolution, coastal digital elevation models (DEMs) that integrate ocean bathymetry and land topography to support NOAA's mission to...

  12. An Analysis of the Relationship Between the Professionalism of Defense Acquisition Program Managers and Program Outcomes

    Science.gov (United States)

    2011-11-30

    concerns with profitability (Bartel, 2000; Phillips, 1996) or by HR specialists’ concerns to justify their budgets ( Geber , 1996; Institute of...Program, Naval Postgraduate School, Monterey, CA. Geber , B. (1996). Does training make a difference? Prove it! Training, 32(3), 27–34. General Accounting

  13. A Basis for a Command, Control and Communications (C3) System Architecture for the Argentine Army

    Science.gov (United States)

    1990-03-01

    needed on the bat- tlefield, Most commanders derive important situational clues by listening to how their subordinates sound in their verbal reports. F...0142 2 Naval Postgraduate School Monterey, CA 93943-5002 3. Estado Mayor General del Ejercito Argentino 5 Direccion de Comunicaciones Azopardo 250

  14. Coastal currents and mass transport of surface sediments over the shelf regions of Monterey Bay, California

    Science.gov (United States)

    Wolf, S.C.

    1970-01-01

    In Monterey Bay, the highest concentrations of medium and fine sands occur nearshore between ten and thirty fathoms. Silt and clay accumulate in greater depths. Contours of median diameter roughly parallel the isobaths. Fine-grained materials are supplied to the bay region from erosion of cliffs which partly surround Monterey Bay, from sediment laden river discharge, and from continual reworking of widespread Pleistocene and Recent sea floor sediments. These sediments in turn are picked up by coastal currents and distributed over the shelf regions by present day current regimes. Studies of bottom currents over the shelf regions and in Monterey Canyon have revealed patterns which vary with seasonal changes. Current patterns during August and September exhibit remarkable symmetry about the axis of Monterey Submarine Canyon. Central Shelf currents north and south of Monterey Canyon flowed northwest at an average rate of 0.2 knots and south at 0.3 knots respectively. On the North Shelf between January and March currents flowed east to southeast at 0.3-0.5 knots with mirror image patterns above the South Shelf during the same period. Irregular current flow in the canyon indicates a complex current structure with frequent shifts in counterclockwise and clockwise direction over very short periods of time. Bottom topography of the canyon complex often causes localization of canyon currents. One particular observation at a depth of 51 fathoms indicated up-canyon flow at a rate of 0.2 knots. Most of the observed currents are related to seasonal variations, upwelling, ocean swell patterns, and to changes in the California and Davidson currents. Changes in current regimes are reflected in the patterns of sediment distribution and transport. Sediment transport is chiefly parallel to the isobaths, particularly on the North and South Shelf regions. Complex dispersal patterns are observed near Monterey Canyon and Moss Landing Harbor jetties. Longshore currents move sediments

  15. Design and Testing of a Combustor for a Turbo-Ramjet Engine for UAV and Missile Applications

    Science.gov (United States)

    2003-03-01

    CA, September 1999. 6. Al- Namani , S . M., Development of Shrouded Turbojet to Form a Turboramjet for Future Missile Applications, Master’s Thesis...Turbo- ramjet Engine for UAV and Missile Applications 6. AUTHOR( S ) Ross H. Piper III 5. FUNDING NUMBERS 7. PERFORMING ORGANIZATION NAME( S ) AND...ADDRESS(ES) Naval Postgraduate School Monterey, CA 93943-5000 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING / MONITORING AGENCY NAME( S

  16. Assessing the Deterrence Value of Carrier Presence Against Adversary Aggression in a Coalition Environment

    Science.gov (United States)

    2017-09-01

    provides statistics on nations’ military forces and defense expenditures. The cost for a player to seek an alliance with a nation, defined as the...summary. Report, Naval Postgraduate School, Monterey, CA. Barnes J, Kleck G (2014) Do more police lead to more crime deterrence? Crime & Delinquency

  17. Making the Case for Humanitarian Intervention: National Interest and Moral Imperative

    Science.gov (United States)

    2015-03-01

    School REPORT NUMBER Monterey, CA 93943-5000 9. SPONSORING /MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSORING/MONITORING NIA AGENCY REPORT...71 Weitz, Project on National Security Reform, 505 –6. 72 Cohen, One Hundred Days of Silence, 6. 73 Weitz, Project on National Security Reform, 987

  18. Cold seeps in Monterey Bay, California: Geochemistry of pore waters and relationship to benthic foraminiferal calcite

    International Nuclear Information System (INIS)

    Gieskes, Joris; Rathburn, Anthony E.; Martin, Jonathan B.; Perez, M. Elena; Mahn, Chris; Bernhard, Joan M.; Day, Shelley

    2011-01-01

    Highlights: → We describe the geochemistry of pore waters in the Clam Flats area of Monterey Bay. → The geochemical data are compared with the δ 13 C chemistry of benthic foraminifera. → Living foraminifera indicate little effects of pore water low δ 13 C (DIC) in the clam bed. → This phenomenon and its implications are discussed in detail. → Implications with regards to paleo-methane seepage are discussed. - Abstract: An extensive geochemical and biogeochemical examination of CH 4 seeps in the Clam Flats area of Monterey Bay provides insight into the character of relationships between seep geochemistry and benthic foraminiferal geochemistry. The area is characterized by sulfide-rich fluids. Sulfide increases are associated with large increases in alkalinity, as well as small decreases in dissolved Ca and Mg. In addition, only small increases in NH 4 are observed, but values of δ 13 C of dissolved inorganic C are as low as -60 per mille at shallow depths ( 4 , which is transported upward by slow seepage of pore fluids. The geochemistry of the pore fluids should be relevant to the geochemistry of the carbonate tests of living and dead foraminifera. However, a profound disequilibrium of approximately an order of magnitude occurs between the δ 13 C values of stained (cytoplasm-containing) foraminiferal carbonate and the C isotope values of ambient pore water dissolved inorganic C. Reasons are unclear for this isotopic disequilibrium, but have important implications for interpretations of foraminiferal carbonate as a paleoenvironmental proxy. Much fine scale work is needed to fully understand the relationships between the biogeochemistry of benthic foraminifera and the geochemistry of the pore waters where they live.

  19. Deployment of a Long-Term Broadband Seafloor Observatory in Monterey Bay

    Science.gov (United States)

    McGill, P.; Neuhauser, D.; Stakes, D.; Romanowicz, B.; Ramirez, T.; Uhrhammer, R.

    2002-12-01

    MOBB (Monterey bay Ocean floor Broad Band project) is a collaborative project between the Monterey Bay Aquarium Research Institute (MBARI) and the Berkeley Seismological Laboratory (BSL). Its goal is to install and operate a permanent seafloor broadband seismic station as a first step towards extending the on-shore broadband seismic network in northern California to the seaside of the North-America/Pacific plate boundary, providing better azimuthal coverage for regional earthquake and structure studies. The successful MOBB deployment took place 40km off shore at a water depth of 1000m during three dives on April 9-11, 2002. The seismometer was buried in a 60-cm deep caisson, which was later back filled with glass beads to stabilize the instrument. New tools, including a high-pressure water-jet excavator, were developed for the ROV Ventana to accomplish these tasks. The ocean-bottom MOBB station currently comprises a three-component seismometer package, a current-meter, and a recording and battery package. Data recovery dives, during which the recording and battery package will be exchanged, are planned every three months for the next three years. A differential pressure gauge (DPG) (Cox et al., 1984) will be deployed as part of the recording package during the next data recovery dive in September 2002. The station is currently recording data autonomously. Eventually, it will be linked to the planned (and recently funded) MARS (Monterey Accelerated Research System; rl {http://www.mbari.org/mars/}) cable and provide real-time, continuous seismic data to be merged with the rest of the northern California real-time seismic system. The data are archived at the NCEDC for on-line availability, as part of the Berkeley Digital Seismic Network (BDSN). This project follows the 1997 MOISE experiment, in which a three-component broadband system was deployed for a period of three months, 40km off shore in Monterey Bay. MOISE was a cooperative program sponsored by MBARI, UC

  20. Families of miocene monterey crude oil, seep, and tarball samples, coastal California

    Science.gov (United States)

    Peters, K.E.; Hostettler, F.D.; Lorenson, T.D.; Rosenbauer, R.J.

    2008-01-01

    Biomarker and stable carbon isotope ratios were used to infer the age, lithology, organic matter input, and depositional environment of the source rocks for 388 samples of produced crude oil, seep oil, and tarballs to better assess their origins and distributions in coastal California. These samples were used to construct a chemometric (multivariate statistical) decision tree to classify 288 additional samples. The results identify three tribes of 13C-rich oil samples inferred to originate from thermally mature equivalents of the clayey-siliceous, carbonaceous marl and lower calcareous-siliceous members of the Monterey Formation at Naples Beach near Santa Barbara. An attempt to correlate these families to rock extracts from these members in the nearby COST (continental offshore stratigraphic test) (OCS-Cal 78-164) well failed, at least in part because the rocks are thermally immature. Geochemical similarities among the oil tribes and their widespread distribution support the prograding margin model or the banktop-slope-basin model instead of the ridge-and-basin model for the deposition of the Monterey Formation. Tribe 1 contains four oil families having geochemical traits of clay-rich marine shale source rock deposited under suboxic conditions with substantial higher plant input. Tribe 2 contains four oil families with traits intermediate between tribes 1 and 3, except for abundant 28,30-bisnorhopane, indicating suboxic to anoxic marine marl source rock with hemipelagic input. Tribe 3 contains five oil families with traits of distal marine carbonate source rock deposited under anoxic conditions with pelagic but little or no higher plant input. Tribes 1 and 2 occur mainly south of Point Conception in paleogeographic settings where deep burial of the Monterey source rock favored petroleum generation from all three members or their equivalents. In this area, oil from the clayey-siliceous and carbonaceous marl members (tribes 1 and 2) may overwhelm that from the lower

  1. 15 CFR Appendix D to Subpart M of... - Dredged Material Disposal Sites Adjacent to the Monterey Bay National Marine Sanctuary

    Science.gov (United States)

    2010-01-01

    ... Adjacent to the Monterey Bay National Marine Sanctuary D Appendix D to Subpart M of Part 922 Commerce and... SANCTUARY PROGRAM REGULATIONS Monterey Bay National Marine Sanctuary Pt. 922, Subpt. M, App. D Appendix D to... Sanctuary [Coordinates in this appendix are unprojected (Geographic Coordinate System) and are calculated...

  2. Monterey Bay ambient noise profiles using underwater gliders

    OpenAIRE

    Chandrayadula, Tarun K.; Miller, Chris W.; Joseph, John

    2013-01-01

    The article of record as published may be found at http://dx.doi.org/10.1121/1.4799131 In 2012, during two separate week-long deployments, underwater gliders outfitted with external hydrophones profiled the upper 100-200 m of the Monterey Bay. The environment contained various noises made by marine mammals, ships, winds, and earthquakes. Unlike hydrophone receivers moored to a fixed location, moving gliders measure noise variability across a wide terrain. However, underwater mobile s...

  3. Cold seeps in Monterey Bay, California: Geochemistry of pore waters and relationship to benthic foraminiferal calcite

    Energy Technology Data Exchange (ETDEWEB)

    Gieskes, Joris, E-mail: jgieskes@ucsd.edu [Scripps Institution of Oceanography, IOD-0208, 9500 Gilman Drive, La Jolla, CA 92093-0208 (United States); Rathburn, Anthony E. [Scripps Institution of Oceanography, IOD-0208, 9500 Gilman Drive, La Jolla, CA 92093-0208 (United States)] [Indiana State University, Department of Earth and Environmental Systems, Terre Haute, IN 47809 (United States); Martin, Jonathan B. [University of Florida, Department of Geological Sciences, Gainesville, FL 32611-2120 (United States); Perez, M. Elena [Indiana State University, Department of Earth and Environmental Systems, Terre Haute, IN 47809 (United States)] [The Natural History Museum, Department of Palaeontology, Cromwell Road, London SW7 5BD (United Kingdom); Mahn, Chris [Scripps Institution of Oceanography, IOD-0208, 9500 Gilman Drive, La Jolla, CA 92093-0208 (United States); Bernhard, Joan M. [Woods Hole Oceanographic Institution, Geology and Geophysics Department, MS52, Woods Hole, MA 02543 (United States); Day, Shelley [University of Florida, Department of Geological Sciences, Gainesville, FL 32611-2120 (United States)

    2011-05-15

    Highlights: > We describe the geochemistry of pore waters in the Clam Flats area of Monterey Bay. > The geochemical data are compared with the {delta}{sup 13}C chemistry of benthic foraminifera. > Living foraminifera indicate little effects of pore water low {delta}{sup 13}C (DIC) in the clam bed. > This phenomenon and its implications are discussed in detail. > Implications with regards to paleo-methane seepage are discussed. - Abstract: An extensive geochemical and biogeochemical examination of CH{sub 4} seeps in the Clam Flats area of Monterey Bay provides insight into the character of relationships between seep geochemistry and benthic foraminiferal geochemistry. The area is characterized by sulfide-rich fluids. Sulfide increases are associated with large increases in alkalinity, as well as small decreases in dissolved Ca and Mg. In addition, only small increases in NH{sub 4} are observed, but values of {delta}{sup 13}C of dissolved inorganic C are as low as -60 per mille at shallow depths (<3 cm). These observations indicate that all these processes are related to the bacterial oxidation of CH{sub 4}, which is transported upward by slow seepage of pore fluids. The geochemistry of the pore fluids should be relevant to the geochemistry of the carbonate tests of living and dead foraminifera. However, a profound disequilibrium of approximately an order of magnitude occurs between the {delta}{sup 13}C values of stained (cytoplasm-containing) foraminiferal carbonate and the C isotope values of ambient pore water dissolved inorganic C. Reasons are unclear for this isotopic disequilibrium, but have important implications for interpretations of foraminiferal carbonate as a paleoenvironmental proxy. Much fine scale work is needed to fully understand the relationships between the biogeochemistry of benthic foraminifera and the geochemistry of the pore waters where they live.

  4. Rethinking the Systems Engineering Process in Light of Design Thinking

    Science.gov (United States)

    2016-04-30

    systems engineering process models (Blanchard & Fabrycky, 1990) and the majority of engineering design education (Dym et al., 2005). The waterfall model ...Engineering Career Competency Model Clifford Whitcomb, Systems Engineering Professor, NPS Corina White, Systems Engineering Research Associate, NPS...Postgraduate School (NPS) in Monterey, CA. He teaches and conducts research in the design of enterprise systems, systems modeling , and system

  5. Microwave Plasma Based Single-Step Method for Generation of Carbon Nanostructures

    Science.gov (United States)

    2013-07-01

    Técnico, Technical University of Lisbon, Portugal 2 Mechanical and Aerospace Engeneering , Naval Postgraduate School, Monterey, CA 93943, U.S.A...applications include electronic devices, transparent conductive films, mechanical devices, chemical sensors, spintronic devices. Moreover, it shows enormous...potential as a storage material for energy applications. Graphene of highest quality can be obtained by mechanically exfoliating highly oriented

  6. Numerical Simulation of Recent Turbidity Currents in the Monterey Canyon System, Offshore California

    Science.gov (United States)

    Heimsund, S.; Xu, J.; Nemec, W.

    2007-12-01

    The method of computational fluid dynamics (CFD) has been used, in the form of a 3D numerical model (Flow- 3D®), to perform a full-scale simulation of turbidity currents measured in December 2002 by three moorings in the Soquel and Monterey canyons. The model was verified by simulation of laboratory flows, and was upscaled to the Monterey Canyon system on the basis of high-resolution bathymetric data and flow measurements. The measured velocity profiles were sufficient to assess the flow thickness, initial velocity and duration in the canyon head zone. A computational grid with a highest feasible resolution was used, and both bathymetry and hydrostatic pressure were accounted for. The volumetric sediment concentration and exact grain- size composition of the flows were unknown, and thus a range of values for the initial concentration and bed roughness were assumed and assessed on a trial-and-error basis. The simulations reveal the behavior of a turbidity current along its descent path, including its local hydraulic characteristics (the 3D field of velocity, sediment concentration, shear stress, strain rate, and dynamic viscosity, as well as the magnitude of velocity and turbulent shear). The results confirm that the velocity structure of turbidity current is highly sensitive to variation in seafloor topography. The December 17th flow in the Soquel Canyon appears to have lost capacity by dilution over a relatively short distance and shown significant velocity fluctuations, which is attributed to the rugged topography of the canyon floor. A major loss of momentum occurred when the flow plunged at high angle into the Monterey Canyon, crashing against its bend's southern wall. The December 20th flow in the Monterey Canyon, in contrast, developed a considerably longer body and strongly accelerated towards the canyon's sharp second bend before crashing against its western wall. The mooring data show a down-canyon decline of velocity and suggest gradual waning, but the

  7. Megacity analysis: a clustering approach to classification

    Science.gov (United States)

    2017-06-01

    overview. Retrieved from https://www.usaid.gov/news-information/fact-sheets/kabul- urban -water-supply- kuws USGS. (2009). Conceptual model of water...PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School Monterey, CA 93943-5000 8. PERFORMING ORGANIZATION REPORT NUMBER 9...is interested in these megacity networks and their implications for potential urban operations. We develop a methodology to group like megacities

  8. Selection of a Planning Horizon for a Hybrid Microgrid Using Simulated Wind Forecasts

    Science.gov (United States)

    2014-12-01

    microgrid robustness and efficiency and may provide operators with real-time guidance and control policies for microgrid operation. ACKNOWLEDGMENTS The...A PLANNING HORIZON FOR A HYBRID MICROGRID USING SIMULATED WIND FORECASTS Mumtaz Karatas Turkish Naval Academy Tuzla, Istanbul, 34942, TURKEY Emily M...Craparo Dashi I. Singham Naval Postgraduate School 1411 Cunningham Road Monterey, CA, 93943 USA ABSTRACT Hybrid microgrids containing renewable energy

  9. Pulse Width Modulator Controller Design for a Brushless DC Motor Position Servo.

    Science.gov (United States)

    1987-06-01

    REQC1,REQC2, lAB, ZEC , ICA, 4. + PVAO, Fy5, PVCO,NODE,TRIG1,TRIG2,TRIG3 ,TRIG4, + TRIG5,TRIGS,RA,PLUGVAIMD,VBIND,VCIND) c call TCONST(ICQl, .75-SWl...DC Motors, Master’s Thesis, Naval Postgraduate School, Monterey, Ca., September 1984. 2. MacMillan, Peter N., A CSMP Commutation Model for .’. Design

  10. Heterogeneous Defensive Naval Weapon Assignment To Swarming Threats In Real Time

    Science.gov (United States)

    2016-03-01

    come under fire from multiple sources simultaneously. These threats would be engaged in a numbers game , seeking to saturate the battlespace with many...optimization extension that uses the Python modeling language. B. TEST SCENARIO The following test scenario was developed to validate the models...Adaptive rapid response to swarming threats Concept Briefing. Presented at Naval Postgraduate School, Monterey, CA. Python [Computer Software]. (2015

  11. Sediment dynamics and the burial and exhumation of bedrock reefs along an emergent coastline as elucidated by repetitive sonar surveys: Northern Monterey Bay, CA

    Science.gov (United States)

    Storlazzi, C.D.; Fregoso, T.A.; Golden, N.E.; Finlayson, D.P.

    2011-01-01

    Two high-resolution bathymetric and acoustic backscatter sonar surveys were conducted along the energetic emergent inner shelf of northern Monterey Bay, CA, USA, in the fall of 2005 and the spring of 2006 to determine the impact of winter storm waves, beach erosion, and river floods on biologically-important siliclastic bedrock reef habitats. The surveys extended from water depths of 4 m to 22 m and covered an area of 3.14 km2, 45.8% of which was bedrock, gravel, and coarse-grained sand and 54.2% was fine-grained sand. Our analyses of the bathymetric and acoustic backscatter data demonstrates that during the 6 months between surveys, 11.4% of the study area was buried by fine-grained sand while erosion resulted in the exposure of bedrock or coarse-grained sand over 26.5% of the study area. The probability of burial decreased with increasing water depth and rugosity; the probability of exhumation increased with increasing wave-induced near-bed shear stress, seabed slope and rugosity. Much of the detected change was at the boundary between bedrock and unconsolidated sediment due to sedimentation and erosion burying or exhuming bedrock, respectively. In a number of cases, however, the change in seabed character was apparently due to changes in sediment grain size when scour exposed what appeared to be an underlying coarser-grained lag or the burial of coarser-grained sand and gravel by fine-grained sand. These findings suggest that, in some places, (a) burial and exhumation of nearshore bedrock reefs along rocky, energetic inner shelves occurs over seasonal timescales and appears related to intrinsic factors such as seabed morphology and extrinsic factors such as wave forces, and (b) single acoustic surveys typically employed for geologic characterization and/or habitat mapping may not adequately characterize the geomorphologic and sedimentologic nature of these types of environments that typify most of the Pacific Ocean and up to 50% of the world's coastlines.

  12. Daylight Redirecting Window Film

    Science.gov (United States)

    2013-12-01

    Fort Bliss , TX; Clovis Vaughn and Andrew Burton at 29 Palms, CA; Doug Taber at Naval Post Graduate School (NPS), Monterey; and Mitch Hailey at Naval...Agarwal and Tim Perry for their immense contribution to this project. Finally, throughout the project, the guidance and counseling of Vern Novstrup at...and control) VA Norfolk Z-133 1 1 1 6 72 48 120 CA 29 Palms 1416 5 7 14 13 108 31 62 RI Newport Hewitt Hall 2 5 9 19 88 24 40 TX Fort Bliss

  13. The monterey bay broadband ocean bottom seismic observatory

    Directory of Open Access Journals (Sweden)

    R. Uhrhammer

    2006-06-01

    Full Text Available We report on the installation of a long-term buried ocean-floor broadband seismic station (MOBB in Monterey Bay, California (USA, 40km off-shore, at a water depth of 1000 m. The station was installed in April 2002 using a ship and ROV, in a collaborative effort between the Monterey Bay Aquarium Research Institute (MBARI and the Berkeley Seismological Laboratory (BSL. The station is located on the western side of the San Gregorio Fault, a major fault in the San Andreas plate boundary fault system. In addition to a 3-component CMG-1T seismometer package, the station comprises a current meter and Differential Pressure Gauge, both sampled at high-enough frequency (1 Hz to allow the study of relations between background noise on the seismometers and ocean waves and currents. The proximity of several land-based broadband seismic stations of the Berkeley Digital Seismic Network allows insightful comparisons of land/ocean background seismic noise at periods relevant to regional and teleseismic studies. The station is currently autonomous. Recording and battery packages are exchanged every 3 months during scheduled one day dives. Ultimately, this station will be linked to shore using continuous telemetry (cable and/or buoy and will contribute to the earthquake notification system in Northern California. We present examples of earthquake and noise data recorded during the first 6 months of operation of MOBB. Lessons learned from these and continued recordings will help understand the nature and character of background noise in regional off-shore environments and provide a reference for the installation of future off-shore temporary and permanent broadband seismic stations.

  14. Utilization of Forward Error Correction (FEC) Techniques With Extensible Markup Language (XML) Schema-Based Binary Compression (XSBC) Technology

    Science.gov (United States)

    2004-12-01

    NY 7. Erik Chaum NUWC Newport, RI 8. David Bellino NPRI Newport, RI 9. Dick Nadolink NUWC Newport, RI 10. VADM Roger Bacon (Ret...Science Advisor Pearl Harbor, HI 16. LT Andrew Hurvitz, USN FNMOC Monterey, CA 17. ENS Darin Keeter, USN FNMOC Monterey, CA 18. CAPT David

  15. Arms Production in Venezuela.

    Science.gov (United States)

    1987-12-01

    studied engineering in the United States. Cardoen produces a wide spectrum of munitions, security equipment and especially armored vehicles, and has...capabilities are: a. The amount of capital available for investment. Arms industry development requires enormous amounts of capital, especially if the...Naval Postgraduate School Monterey, CA 93943-5100 5. Director de Educacion de La Armada 1 Comandancia General de La Armada Av. Vollmer, Urb. San

  16. An Analysis of Navy Nurse Corps Accession Sources

    Science.gov (United States)

    2014-03-01

    1 I. INTRODUCTION A. BACKGROUND Since 1998, the United States has experienced a nationwide nursing shortage (Juraschek, Zhang, Ranganathan ...supply of RNs in the civilian workforce (Juraschek, Zhang, Ranganathan , & Lin, 2012). A study by Juraschek, Zhang, Ranganathan , & Lin (2012...Postgraduate School, Monterey, CA. Retrieved from www.dtic.mil/cgi- bin/GetTRDoc?AD=ADA344570 Juraschek, S. P., Zhang, X., Ranganathan , V. K., & Lin, V

  17. CV or Not to Be? Alternatives to U.S. Sea-Based Air Power

    Science.gov (United States)

    2008-06-01

    FUNDING NUMBERS 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School Monterey, CA 93943-5000 8. PERFORMING ORGANIZATION REPORT...Stuart E. Johnson and Arthur K. Cebrowski, Alternative Fleet Architechture Design (Fort Lesley J. McNair, Washington D.C.: National Defense University...clock, immune to hazards such as sandstorms that grounded land-based aircraft. Organic air wings provided strike, electronic attack, airborne early

  18. The Cold Gas-Dynamic Spray and Characterization of Microcrystalline and Nanocrystalline Copper Alloys

    Science.gov (United States)

    2012-12-01

    set—the vial itself is constructed of a polycarbonate shell with stainless steel end plugs with a stainless steel impactor contained within the vial...Alloying of Refractory Metals in Austenitic and Ferritic/ Martensitic Steels ,” M.S. Thesis, MAE Dept., Naval Postgraduate School, Monterey, CA, 2012...Process. From [2]. .....................................................5  Figure 3.  Individual Particle after Impact with a Steel Substrate. From [15

  19. Further Results on Constructions of Generalized Bent Boolean Functions

    Science.gov (United States)

    2016-03-01

    China; 2Naval Postgraduate School, Applied Mathematics Department, Monterey, CA 93943, USA; 3Science and Technology on Communication Security...in 1976 as an interesting combinatorial object with the important property of having op- timal nonlinearity [1]. Since bent functions have many...77–94 10 Zhao Y, Li H L. On bent functions with some symmet- ric properties. Discret Appl Math, 2006, 154: 2537– 2543

  20. Aerial Remote Radio Frequency Identification System for Small Vessel Monitoring

    Science.gov (United States)

    2009-12-01

    technology as a tool that can benefit everyone (Warner 2008, p.144). Lippitt’s model , coupled with Vroom and Lawler’s Expectancy Theory (Miner 2005, p...Identification System for Small Vessel Monitoring 6. AUTHOR( S ) Jason Appler, Sean Finney, Michael McMellon 5. FUNDING NUMBERS 7. PERFORMING...ORGANIZATION NAME( S ) AND ADDRESS(ES) Naval Postgraduate School Monterey, CA 93943-5000 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING

  1. The End of Monterey Submarine Canyon Incision and Potential River Source Areas-Os, Nd, and Pb Isotope Constraints from Hydrogenetic Fe-Mn Crusts

    Science.gov (United States)

    Conrad, T. A.; Nielsen, S.; Ehrenbrink, B. P. E.; Blusztajn, J.; Hein, J. R.; Paytan, A.

    2015-12-01

    The Monterey Canyon off central California is the largest submarine canyon off North America and is comparable in scale to the Grand Canyon. The age and history of the Monterey Canyon are poorly constrained due to thick sediment cover and sediment disruption from turbidity currents. To address this deficit we analyzed isotopic proxies (Os, Pb, Nd) from hydrogenetic ferromanganese (Fe-Mn) crusts, which grow over millions of years on elevated rock surfaces by precipitation of metals from seawater. Fe-Mn crusts were studied from Davidson Seamount near the base of the Monterey submarine fan, the Taney Seamount Chain, and from Hoss Seamount, which serves as a regional control (Fig.). Fe-Mn crusts were dated using Os isotope ratios compared to those that define the Cenozoic Os isotope seawater curve. Four Fe-Mn crust samples from Davidson and Taney Seamounts deviate from the Os isotopic seawater curve towards radiogenic values after 4.5±1 Ma. Osmium is well mixed in the global ocean and is not subject to significant diffusive reequilibration in Fe-Mn crusts. We therefore attribute deviations from the Os isotope seawater curve to large-scale terrestrial input that ended about 4.5±1 Ma. The two Davidson samples also show more radiogenic Nd isotope values from about 4.5±1 Ma. Lead isotopes in one Davidson Seamount crust, measured by LA-ICPMS, deviate from regional values after 4.5±1 Ma for about 500 ka towards terrestrial sources. The Taney Seamount Fe-Mn crust does not deviate from regional Nd nor Pb isotope values due to its greater distance from Monterey Canyon and the shorter marine residence times of Nd and Pb. Isotope plots of our crust data and compiled data for potential source rocks indicate that the river that carved Monterey Canyon carried sediment with values closer to the Sierra Nevada than to a Colorado Plateau source, with cessation of major riverine input occurring approximately 4.5±1 Ma, an age that we interpret as the end of the Monterey Canyon

  2. The completed Management Information System for the Monterey Navy Flying Club.

    OpenAIRE

    Graham, James M.

    1987-01-01

    Approved for public release; distribution in unlimited. This thesis provides a completed Management Information System for the Monterey Navy Flying Club. The software package was designed to operate upon an IBM PC-XT or PC-AT or 100% compatible microcomputer wjiich has 384K of main memory. Specific hardware requirements are discussed in chapter one. This software package supplies the necessary tools for the club manager to maintain all club records and generate required a...

  3. Groundwater quality in the shallow aquifers of the Monterey Bay, Salinas Valley, and adjacent highland areas, Southern Coast Ranges, California

    Science.gov (United States)

    Burton, Carmen

    2018-05-30

    The Monterey-Salinas Shallow Aquifer study unit covers approximately 7,820 square kilometers (km2) in Santa Cruz, Monterey, and San Luis Obispo Counties in the Central Coast Hydrologic Region of California. The study unit was divided into four study areas—Santa Cruz, Pajaro Valley, Salinas Valley, and Highlands. More than 75 percent of the water used for drinking-water supply in the Central Coast Hydrologic Region of California is groundwater, and there are more than 8,000 well driller’s logs for domestic wells (California Department of Water Resources, 2013).

  4. Latent infection by Fusarium circinatum influences susceptibility of monterey pine seedlings to pitch canker

    Science.gov (United States)

    Cassandra L. Swett; Thomas R. Gordon

    2012-01-01

    Pitch canker, caused by Fusarium circinatum, is a serious disease affecting Pinus radiata D. Don (Monterey pine) in nurseries, landscapes, and native forests. A typical symptom of pitch canker is canopy dieback resulting from girdling lesions on terminal branches (Gordon et al. 2001). More extensive dieback can result from...

  5. Sand mining impacts on long-term dune erosion in southern Monterey Bay

    Science.gov (United States)

    Thornton, E.B.; Sallenger, Abby; Sesto, Juan Conforto; Egley, L.; McGee, Timothy; Parsons, Rost

    2006-01-01

    Southern Monterey Bay was the most intensively mined shoreline (with sand removed directly from the surf zone) in the U.S. during the period from 1906 until 1990, when the mines were closed following hypotheses that the mining caused coastal erosion. It is estimated that the yearly averaged amount of mined sand between 1940 and 1984 was 128,000 m3/yr, which is approximately 50% of the yearly average dune volume loss during this period. To assess the impact of sand mining, erosion rates along an 18 km range of shoreline during the times of intensive sand mining (1940–1990) are compared with the rates after sand mining ceased (1990–2004). Most of the shoreline is composed of unconsolidated sand with extensive sand dunes rising up to a height of 46 m, vulnerable to the erosive forces of storm waves. Erosion is defined here as a recession of the top edge of the dune. Recession was determined using stereo-photogrammetry, and LIDAR and GPS surveys. Long-term erosion rates vary from about 0.5 m/yr at Monterey to 1.5 m/yr in the middle of the range, and then decrease northward. Erosion events are episodic and occur when storm waves and high tides coincide, allowing swash to undercut the dune and resulting in permanent recession. Erosion appears to be correlated with the occurrence of El Niños. The calculated volume loss of the dune in southern Monterey Bay during the 1997–98 El Niño winter was 1,820,000 m3, which is almost seven times the historical annual mean dune erosion of 270,000 m3/yr. The alongshore variation in recession rates appears to be a function of the alongshore gradient in mean wave energy and depletions by sand mining. After cessation of sand mining in 1990, the erosion rates decreased at locations in the southern end of the bay but have not significantly changed at other locations.

  6. Accumulation of cesium-137 and strontium-90 in ponderosa pine and monterey pine seedlings

    International Nuclear Information System (INIS)

    Entry, J.A.; Rygiewicz, P.T.; Emmingham, W.H.

    1993-01-01

    Because ponderosa pine Pinus ponderosa and Monterey pone (P. radiata D Don) have exceptionally fast growth rates and their abscised needles are not readily dispersed by wind, these species may be valuable for removing radioisotopes from contaminated soils. Ponderosa and Monterey pine seedlings were tested for their ability to accumulate 137 Cs and 90 Sr-characteristic radioisotopes of nuclear fallout-from contaminated soil. Seedlings were grown for 3 mo in 165 cm 3 sphagnum peat moss/perlite (1:1 V/V) in a growth chamber. In Exp. 1, seedling accumulation of 137 Cs and 90 Sr after 1 mo of exposure was measured. In Exp. 2, seedling accumulation of the radioisotopes during different-length exposures was measured. Seedling accumulation of 137 CS and 90 Sr at different concentrations of the radioisotopes in the growth medium was measured in Exp. 3. Ponderosa pine accumulated 6.3% of the 137 Cs and I.5% of the 90 Sr present in the growth medium after 1 mo; Monterey pine accumulated 8.3% of the 137 Cs and 4.5% of the 90 Sr. Accumulation of 137 Cs and 90 Sr by both coniferous species was curvilinearly related to duration of exposure. Accumulation of 137 Cs and 90 Sr by both species increased with increasing concentration in the growth medium and correlated curvilinearly with radioisotope concentration in the growth medium. Large areas throughout the world are contaminated with 137 Cs and 90 Sr as a result of nuclear weapons testing or atomic reactor accidents. The ability of trees to sequester and store 137 Cs and 90 Sr introduces the possibility of using reforestation to remediate contaminated soils

  7. Effects of Technology on Experienced Job Characteristics and Job Satisfaction.

    Science.gov (United States)

    1980-07-01

    specific function (e.g., manufacture automobiles ), 6 not everyone who works in the organization is directly tied to the production of that output...School Code 1424 Monterey, CA 93940 LIST 7 HRM Officer in Charge Officer in Charge Iuman Resource Management Detachment Human Resource Management Naval...U.S. Naval Force Europe FPO New York 09510 76 LIST 8 NAVY MISCELLANEOUS Naval Military Personnel Command (2 copies) HRM Department (NMPC-6

  8. Analysis of Other Transaction Agreements to Acquire Innovative Renewable Energy Solutions for the Department of the Navy

    Science.gov (United States)

    2016-12-01

    participation by socially and economically disadvantaged small businesses (SDBs), and by women - owned small businesses (WOSBs), in technological...contractor business units that either receive a single CAS- covered contract award of $50M or more or received $50M or more in net CAS-covered contracts...Tobin, Josh Millner, and Casey Gillette 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School Monterey, CA 93943-5000 8

  9. One Size Does Not Fit All: A System Development Perspective

    Science.gov (United States)

    2013-09-09

    Postgraduate School in Monterey, CA. LCDR LaSalle graduated with an Associate of Science degree in nutrition and culinary arts from Johnson & Wales...designs throughout the project. 10. Simplicity is the art of maximizing work done: Simplicity is essential. As Cockburn (2002) stated, “Simplicity...The fifth discipline: The art and practice of the learning organization. New York, NY: Doubleday/Currency. Sengupta, K., Van Oorschot, K. E., & Van

  10. Innovations in Defense Acquisition: Asymmetric Information and Incentive Contract Design

    Science.gov (United States)

    2009-12-15

    selection. As the fixed price increases, consumers who eat the least will be the most likely to stop patronizing the restaurant . Therefore, increasing...mechanism (MBA Professional Report). Monterey, CA: Naval Postgraduate School. Riordan, M.H., & Sappington, D.E.M. (1987). Awarding monopoly franchises ...options from which a contractor can choose. The options provided by the TRIM read like a restaurant menu. Each option on the menu has three

  11. Mediation With Muscle: Understanding When Mediators Commit Resources to Civil War Negotiations

    Science.gov (United States)

    2015-12-01

    unified and cohesive as to allow its negotiators to act without extensive consensus building and persuasion among their own side—certain elements will...UNDERSTANDING WHEN MEDIATORS COMMIT RESOURCES TO CIVIL WAR NEGOTIATIONS by Michael D. Caplan December 2015 Thesis Advisor: T. Camber Warren Second Reader... NEGOTIATIONS 5. FUNDING NUMBERS 6. AUTHOR(S) Michael D. Caplan 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School Monterey, CA

  12. Deception Detection: Accuracy Levels Among International Military Officers Using Content and Contextual Questioning Methods

    Science.gov (United States)

    2016-12-01

    deception than any one method on its own. This research project focuses on students at the Naval Postgraduate School (NPS) in Monterey, CA, to...international military officers were also limited on the type of contextual questioning methods and scenarios. These scenarios were not a very good ...research received participation from 52 students . Although the sample size was small, proportionally, 24% is a good response rate for lab research

  13. Community Preparedness: Alternative Approaches to Citizen Engagement in Homeland Security

    Science.gov (United States)

    2014-06-01

    and largely ignores the social aspects that influence an individual’s beliefs, attitudes and, behaviors.53 Self-efficacy is defined by Albert Bandura ...master’s thesis Naval Postgraduate School, Monterey, CA), 39–52 53 Ibid., 53. 54 Albert Bandura , “Self-efficacy: Toward a Unifying Theory of...Hometown Security: Advancing the Homeland Security Paradigm, Homeland Security Affairs V (2009). http://www.hsaj.org/?fullarticle=5.2.2. Bandura

  14. An Analysis of the Observed Low-level Structure of Rapidly Intensifying and Mature Hurricane Earl (2010)

    Science.gov (United States)

    2014-01-01

    structure. J. Atmos. Sci. 49: 919–942. Marks FD, Black PG, Montgomery MT, Burpee RW. 2008. Structure of the eye and eyewall of hurricane Hugo (1989...structure of rapidly intensifying and mature hurricane Earl (2010) Michael T. Montgomery,a* Jun A. Zhangb and Roger K. Smithc aDepartment of Meteorology...Naval Postgraduate School, Monterey, CA, USA bNOAA Hurricane Research Division, Miami, FL, USA cMeteorological Institute, Ludwig Maximilians, University

  15. Air Force Institute of Technology Research Report 2008

    Science.gov (United States)

    2009-05-01

    Air Force Student, Summer 2008, Naval Postgraduate School, Monterey, CA. FIORINO, STEVEN, T., Lt Col Bartell, R.J., Krizo, M.J., Fiorino, S.T...Tomography. AFIT/GAP/ENP/08-M04. Faculty Advisor: Dr. William F. Bailey. Sponsor: AFRL/RZ. HAUSMAN , ALEXANDER R., Direct Initiation through...Sponsor: 314 OG/CC. MITCHELL, LAWRENCE W.S., Fee for Service Air Refueling: A Summary Market Analysis. AFIT/IMO/ENS/08-12. Faculty Advisor: Dr

  16. Robustifying the Kalman Filter.

    Science.gov (United States)

    1987-11-01

    School Code 55 6c ADDRESN Cq> State and ZiP( odk ,) 7b ADDRE SS(City State and Z/IPCode) Monterey, CA 93943-5000 8a NAME J); ;. ND S"ONSOR’Nu Bt, O FiCE... collected are the estimation error 6n - On for n=25, 50, 75, 100 and the estimate of variance Cn, n=25, 50, 75, 100. The number of independent

  17. Public Safety Communications Centers: Are We Prepared for the New Technologies Coming Our Way?

    Science.gov (United States)

    2014-03-01

    COMING OUR WAY? 5. FUNDING NUMBERS 6. AUTHOR(S) Marc R. Shaw 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School...Monterey, CA 93943-5000 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING /MONITORING AGENCY NAME(S) AND ADDRESS(ES) N/A 10. SPONSORING...excited that I will not miss any more Boy Scout events, theatre shows, softball games, or Girl Scout meetings. Thank you for not driving mommy

  18. Fighting in a Contested Space Environment: Training Marines for Operations with Degraded or Denied Space-Enabled Capabilities

    Science.gov (United States)

    2015-06-01

    TRAINING MARINES FOR OPERATIONS WITH DEGRADED OR DENIED SPACE-ENABLED CAPABILITIES 5. FUNDING NUMBERS 6. AUTHOR(S) David M. Garcia 7. PERFORMING ...ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School Monterey, CA 93943-5000 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING...could possibly have been linked to the blast as well [19]. Space Debris (4) There are over 20,000 pieces of debris the size of a softball or greater

  19. Evaluation of Data Processing Techniques for Unobtrusive Gait Authentication

    Science.gov (United States)

    2014-03-01

    INTENTIONALLY LEFT BLANK xiii LIST OF ACRONYMS AND ABBREVIATIONS API application programming interface BFCC bark-frequency cepstral coefficient...Numpy [39] libraries for the following manipulations. 1. Interpolation Due to a limitation in the Android API , the only time the data is pulled from the...Postgraduate School, Monterey, CA, 2014. 67 [49] V. Nguyen, “Continuous authentication of a smartphone user using RSSI-based geolocation ,” M.S. thesis

  20. Isostatic gravity map of the Monterey 30 x 60 minute quadrangle and adjacent areas, California

    Science.gov (United States)

    Langenheim, V.E.; Stiles, S.R.; Jachens, R.C.

    2002-01-01

    The digital dataset consists of one file (monterey_100k.iso) containing 2,385 gravity stations. The file, monterey_100k.iso, contains the principal facts of the gravity stations, with one point coded per line. The format of the data is described below. Each gravity station has a station name, location (latitude and longitude, NAD27 projection), elevation, and an observed gravity reading. The data are on the IGSN71 datum and the reference ellipsoid is the Geodetic Reference System 1967 (GRS67). The free-air gravity anomalies were calculated using standard formulas (Telford and others, 1976). The Bouguer, curvature, and terrain corrections were applied to the free-air anomaly at each station to determine the complete Bouguer gravity anomalies at a reduction density of 2.67 g/cc. An isostatic correction was then applied to remove the long-wavelength effect of deep crustal and/or upper mantle masses that isostatically support regional topography.

  1. COMPARING SEA LEVEL RESPONSE AT MONTEREY, CALIFORNIA FROM THE 1989 LOMA PRIETA EARTHQUAKE AND THE 1964 GREAT ALASKAN EARTHQUAKE

    Directory of Open Access Journals (Sweden)

    L. C. Breaker

    2009-01-01

    Full Text Available Two of the largest earthquakes to affect water levels in Monterey Bay in recent years were the Loma Prieta Earthquake (LPE of 1989 with a moment magnitude of 6.9, and the Great Alaskan Earthquake (GAE of 1964 with a moment magnitude of 9.2. In this study, we compare the sea level response of these events with a primary focus on their frequency content and how the bay affected it, itself. Singular Spectrum Analysis (SSA was employed to extract the primary frequencies associated with each event. It is not clear how or exactly where the tsunami associated with the LPE was generated, but it occurred inside the bay and most likely began to take on the characteristics of a seiche by the time it reached the tide gauge in Monterey Harbor. Results of the SSA decomposition revealed two primary periods of oscillation, 9-10 minutes, and 31-32 minutes. The first oscillation is in agreement with the range of periods for the expected natural oscillations of Monterey Harbor, and the second oscillation is consistent with a bay-wide oscillation or seiche mode. SSA decomposition of the GAE revealed several sequences of oscillations all with a period of approximately 37 minutes, which corresponds to the predicted, and previously observed, transverse mode of oscillation for Monterey Bay. In this case, it appears that this tsunami produced quarter-wave resonance within the bay consistent with its seiche-like response. Overall, the sea level responses to the LPE and GAE differed greatly, not only because of the large difference in their magnitudes but also because the driving force in one case occurred inside the bay (LPE, and in the second, outside the bay (GAE. As a result, different modes of oscillation were excited.

  2. The Evolution of the Automated Continuous Evaluation System (ACES) for Personnel Security

    Science.gov (United States)

    2013-11-12

    to capture and transmit fingerprints . • Accurate Biometrics , a commercial Livescan fingerprinting provider, also received fingerprints electronically...FOUO). Monterey, CA: Defense Personnel Security Research Center. Herbig, K. L. (2008). Changes in espionage by American citizens , 1947-2007. (Tech...by American citizens , 1947-2001. (Tech. Rep. 02-05). Monterey, CA: Defense Personnel Security Research Center. Heuer, Jr., R. J., Crawford, K. S

  3. MOBB: a permanent ocean floor broadband seismic observatory in Monterey Bay, California

    Science.gov (United States)

    Uhrhammer, R.; Romanowicz, B.; Stakes, D.; Neuhauser, D.; McGill, P.; Ramirez, T.

    2003-04-01

    The Monterey ocean bottom broadband station (MOBB) was installed on the seafloor in Monterey Bay, 40 km offshore, and at a depth of 1000m from the sea surface, on April 9-11, 2002. Its success capitalizes on the experience gained in the 1997 International MOISE experiment, conducted under similar conditions. The deployment took place during 3 dives on consecutive days and made use of MBARI's Point Lobos ship and ROV Ventana. The station is currently recording data autonomously. Eventually, it will be linked to the planned (and recently funded) MARS (Monterey Accelerated Research System; \\url {http://www.mbari.org/mars/}) cable and provide real-time, continuous seismic data to be merged with the rest of the northern California real-time seismic system. The data are archived at the NCEDC for on-line availability, as part of the Berkeley Digital Seismic Network (BDSN). The ocean-bottom MOBB station currently comprises a three-component seismometer package, a current-meter, a DPG, and recording and battery packages. The seismic package contains a low-power (2.2W), three-component CMG-1T broadband seismometer system, built by Guralp, Inc., with a three-component 24-bit digitizer, a leveling system, and a precision clock. The seismometer package is mounted on a cylindrical titanium pressure vessel 54cm in height and 41 cm in diameter, custom built by the MBARI team and outfitted for underwater connection. Data recovery dives, during which the recording and battery package will be exchanged are planned every three months for the next 3 years. Three such dives have already taken place, on 06/27/02, 09/20/02 and on 01/07/03. Due to a software problem, data were lost during the time period 07/01/02 and 09/20/02. Many regional and teleseismic earthquakes have been well recorded and the mass position signals indicate that the instruments have progressively settled. Preliminary analysis of data retrieved during the 2002 summer and winter dives will be presented. In particular

  4. Leadership and Management Education and Training (LMET) Effectiveness: A Pilot Study for Evaluation.

    Science.gov (United States)

    1981-06-01

    leadership / management theory complete with a specific vocabulary. This new vocabulary allows the graduate to be able to converse easier with...AD-AlG 9 NAVAL POSTGRADUATE SCHOOL MONTEREY CA F/S 5/1 LEADERSHIP AND MANAGEMENT EDUCATION AND TRAINING (LMET) EFFECTI-ECU UNLSIID JUN 81 D L...TITLE (A~d 8ItI. )o------~. .hss COVERED Leadership and Management Education and Training 198 (LMET) Effectiveness: A Pilot-Study for 6-- . *P.W..@*.On

  5. Numerical Electromagnetic Models of Cube-Shaped Boxes - An Initial Investigation for Near-Field Prediction of HF Shipboard Environments

    Science.gov (United States)

    1987-12-01

    de Armamento y Electronica 2 Comandancia de la Armada Av. Vollmer San Benardino Caracas, 1011 Venezuela 10. Director de Comunicaciones 2 Comandancia...Prof. Harry Atwater, Code 62An 1 Naval Postgraduate School Monterey, CA 93943-5000 6. Capitdn de Corbeta 5 Carlos R Molina T Comandancia de la Armada Av...Vollmer San Benardino Caracas, 1011 Venezuela 7. Escuela Naval de Venezuela 2 Director Comandancia de la Armada Av. Vollmer San Benardino Caracas

  6. Passive Coherent Detection and Target Location with Multiple Non-Cooperative Transmitters

    Science.gov (United States)

    2015-06-01

    NUMBERS 6. AUTHOR(S) Qinling Jeanette Olivia Tan 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School Monterey, CA 93943-5000...8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING /MONITORING AGENCY NAME(S) AND ADDRESS(ES) N/A 10. SPONSORING/MONITORING AGENCY...UHF TV (analogue) ~550 MHz Vestigial -Sideband AM (vision); FM(sound), 5.5 MHz 1 MW -51 dBW m -2 at r1 = 100 km Digital audio broadcast ~220

  7. Optimization of Shipboard Manning Levels Using Imprint Pro Forces Module

    Science.gov (United States)

    2015-09-01

    is working on correcting much of the feedback from our study, the issues the study encountered were many. The batch runner could only complete 35...file for the batch runner . Finally, the reports that were created by the batch runner were in an INPRINT Pro specific format, which required...command resilience of watchstanders on the “five and dime” watchbill (Technical Report No. NPS-OR-15-003). Monterey, CA: Naval Postgraduate School

  8. Energy Forecasting Models Within the Department of the Navy.

    Science.gov (United States)

    1982-06-01

    standing the climatic conditions responsible for the results. Both models have particular advantages in parti- cular applications and will be examined...and moving average processes. A similar notation for a model with seasonality . .- considerations will be ARIMA (p d j)(P Q) 3=12, where the upper...AD-A12l 950 ENERGY FORECASTING MODELS WITHIN THE DEPARTMENT OF THE 1/4 NAYY(U) NAVAL POSTGRADUATE SCHOOL MONTEREY CA L &I BUTTOIPH JUN 82

  9. An Adaptive, Multi-Rate Linear Quadratic Regulator for a Shipboard MVDC Distribution System with Constant Power Loads

    Science.gov (United States)

    2017-09-01

    investigation into the factors which most strongly influence ROA size would be instructive. The genetic algorithm could be modified to assess ROA size and an...DISTRIBUTION SYSTEM WITH CONSTANT POWER LOADS 5. FUNDING NUMBERS REL95 REK4K 6. AUTHOR(S) Adam J. Mills 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS...ES) Naval Postgraduate School Monterey, CA 93943-5000 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING /MONITORING AGENCY NAME(S) AND

  10. Assessing Domestic Right-Wing Extremism Using the Theory of Collective Behavior

    Science.gov (United States)

    2009-12-01

    FUNDING NUMBERS 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School Monterey, CA 93943-5000 8. PERFORMING ORGANIZATION...According to this theory, Rosa Parks was not just an African-American woman who defied a white bus driver because her feet hurt. She was a social activist...introduce a bias into the data. “Cell phone-onlys” are typically in their early 30s, earn less than $50,000 annually, are unmarried , are more

  11. Sensitivity of Tropical Cyclone Models to the Surface Drag Coefficient in Different Boundary-Layer Schemes

    Science.gov (United States)

    2011-10-20

    altitude of about 500 m in Hurricanes Allen (1980) and Hugo (1989) by Zhang et al. (2010). In Hugo these were about 110 m2 s−1 beneath the eyewall...Marks FD Montgomery MT Lorsolo S. 2010 Estimation of turbulence characteristics of eyewall boundary layer of Hurricane Hugo (1989) Mon. Wea. Rev., in...University of Munich, Munich, Germany b Dept. of Meteorology, Naval Postgraduate School, Monterey, CA & NOAA’s Hurricane Research Division ∗Correspondence

  12. The Role of Isolation in Radicalization: How Important Is It?

    Science.gov (United States)

    2013-12-01

    Hug 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School Monterey, CA 93943-5000 8. PERFORMING ORGANIZATION REPORT...bully. The bully punched Timothy, and he fled and wept in the car.133 He felt like a failure to his father, who was an accomplished softball player...psychologists who performed interviews with Breivik. His lack of connection with his parents can also be seen in his compendium in he writes extensively

  13. Computer Aided Prototyping System (CAPS) for Heterogeneous Systems Development and Integration

    OpenAIRE

    Luqi; Berzins, V.; Shing, M.; Nada, N.; Eagle, C.

    2000-01-01

    2000 Command and Control Research and Technology Symposium (CCRTS), June 11-13, 2000, Naval Postgraduate School, Monterey, CA This paper addresses the problem of how to produce reliable software that is also flexible and cost effective for the DoD distributed software domain. DoD software systems fall into two categories: information systems and war fighter systems. Both types of systems can be distributed, heterogeneous and network-based, consisting of a set of components running...

  14. The design and development of a management information system for the Monterey Navy Flying Club.

    OpenAIRE

    George, Derek R.

    1986-01-01

    Approved for public release; distribution is unlimited This thesis provides a Management Information System for the Monterey Navy Flying Club. It supplies the tools necessary to enable the club manager to maintain all club records and generate required administrative and financial reports. http://archive.org/details/designdevelopmen00geor Commander, United States Navy

  15. 78 FR 16628 - Gulf of the Farallones and Monterey Bay National Marine Sanctuaries Regulations on Introduced...

    Science.gov (United States)

    2013-03-18

    ... Register on October 1, 2009 (74 FR 50740) concerning regulations on the introduction of introduced species... Sanctuaries (ONMS) conducted a joint review of the management plans for Gulf of the Farallones, Monterey Bay and Cordell Bank national marine sanctuaries (hereafter referred to as the ``Joint Management Plan...

  16. Navigating the Institutional and Pedagogical Challenges of the Service-Learning Leadership Minor at CSU Monterey Bay

    Science.gov (United States)

    Burke, Deborah A.

    2012-01-01

    Despite solid foundations for service-learning at California State University Monterey Bay (CSUMB), the economic context of higher education in California, and in particular the CSU system, has created significant challenges for service-learning practitioners. This article provides an overview of the institutional foundations in place at CSUMB…

  17. Evaluation of Uniform Cost Accounting System to Fully Capture Depot Level Repair Costs.

    Science.gov (United States)

    1985-12-01

    RD-RI65 522 EVALUATION OF UNIFORM COST ACCOUNTING SYSTEM TO FULLY i/I CAPTURE DEPOT LEVEL REPAIR COSTS (U) NAVAL POSTGRADUATE SCHOOL MONTEREY CA D R...8217.LECTE B ,- THESIS EVALUATION OF UNIFORM COST ACCOUNTING SYSTEM 0TO FULLY CAPTURE DEPOT LEVEL REPAIR COSTS Jby __jDavid Richmond O’Brien lj,,, December...Include Security Classification) EVALUATION OF UNIFORM COST ACCOUNTING SYSTEM TO FULLY CAPTURE DEPOT LEVEL REPAIR COSTS 12 PERSONAL AUTHOR(S) O’Brien- David

  18. Assessment of the Potential for Human Resource Accounting in Venezuelan Navy Management Decision Making.

    Science.gov (United States)

    1981-12-01

    Accounting Association, 1957, op. cit, p. 6. 23. Horngren , Charles, " Cost Accounting : A Managerial Emphasis," Solutions Manual, Prentice-Hall...Model," Management Accounting , December 1977. Savich, R. S . and Ehrenreich, K. E., " Cost /Benefits Analysis of Human Resource Accounting Alternatives...A0A112 T40 NAVAL POSTGRADUATE SCHOOL MONTEREY CA F/ S S / ASSESS1ENT OF THE POTENTIAL FOR HUMAN RESOURCE ACCOUNTING IN VE-ETC(Ul EC GS K FI MARN

  19. The Naval Postgraduate School : The Nation's Premier National Security Research University [video

    OpenAIRE

    2010-01-01

    “The best and brightest military officers from the United States and around the world come to the Naval Postgraduate School in Monterey, California, to work with world class faculty on real military and defense problems. At NPS, they gain both the intellectual know how and the practical skills for improving defense technologies, systems and programs.” -- President George H.W. Bush

  20. Sedimentary processes of the lower Monterey Fan channel and channel-mouth lobe

    Science.gov (United States)

    Klaucke, I.; Masson, D.G.; Kenyon, Neil H.; Gardner, J.V.

    2004-01-01

    The distribution of deposits, sediment transport pathways and processes on the lower Monterey Fan channel and channel-mouth lobe (CML) are studied through the integration of GLORIA and TOBI sidescan sonar data with 7-kHz subbottom profiler records and sediment cores for ground-truthing. The lower Monterey channel is characterised by an up to 30-m-deep channel with poorly developed levees and alternating muddy and silty muddy overbank deposits. The channel is discontinuous, disappearing where gradients are less than about 1:350. Ground-truthing of the large CML shows that the entire CML is characterised by widespread deposits of generally fine sand, with coarser sand at the base of turbidites. Sand is particularly concentrated in finger-like areas of low-backscatter intensity and is interpreted as the result of non-turbulent sediment-gravity flows depositing metres thick massive, fine sand. TOBI sidescan sonar data reveal recent erosional features in the form of scours, secondary channels, large flow slides, and trains of blocks at the distal end of the CML. Erosion is probably related to increasing gradient as the CML approaches Murray Fracture zone and to differential loading of sandy submarine fan deposits onto pelagic clays. Reworking of older flow slides by sediment transport processes on the lobe produces trains of blocks that are several metres in diameter and aligned parallel to the flow direction. ?? 2004 Elsevier B.V. All rights reserved.

  1. Biological marker distribution in coexisting kerogen, bitumen and asphaltenes in Monterey Formation diatomite, California

    Science.gov (United States)

    Tannenbaum, E.; Ruth, E.; Huizinga, B. J.; Kaplan, I. R.

    1986-01-01

    Organic-rich (18.2%) Monterey Formation diatomite from California was studied. The organic matter consist of 94% bitumen and 6% kerogen. Biological markers from the bitumen and from pyrolysates of the coexisting asphaltenes and kerogen were analyzed in order to elucidate the relationship between the various fractions of the organic matter. While 17 alpha(H), 18 alpha(H), 21 alpha(H)-28,30-bisnorhopane was present in the bitumen and in the pryolysate of the asphaltenes, it was not detected in the pyrolysates of the kerogen. A C40-isoprenoid with "head to head" linkage, however, was present in pyrolysates of both kerogen and asphaltenes, but not in the bitumen from the diatomite. The maturation level of the bitumen, based on the extent of isomerization of steranes and hopanes, was that of a mature oil, whereas the pyrolysate from the kerogen showed a considerably lower maturation level. These relationships indicate that the bitumen may not be indigenous to the diatomite and that it is a mature oil that migrated into the rock. We consider the possibility, however, that some of the 28,30-bisnorhopane-rich Monterey Formation oils have not been generated through thermal degradation of kerogen, but have been expelled from the source rock at an early stage of diagenesis.

  2. Analysis of Marketing and Customer Satisfaction in Base Housing Communities of the Monterey Bay Area

    Science.gov (United States)

    2011-06-01

    in Seattle, Washington. The company claims to be based on four basic principles : “exceptional people, strong customer service, market knowledge, and...FtOrd.html Keller, K., & Kotler , P. (2009). A framework for marketing management. Upper Saddle River, NJ: Pearson Education, Inc. Office of...SUBTITLE Analysis of Marketing and Customer Satisfaction in Base Housing Communities of the Monterey Bay Area 5. FUNDING NUMBERS 6. AUTHOR(S

  3. Tropical-Cyclone Flow Asymmetries Induced by a Uniform Flow Revisited

    Science.gov (United States)

    2011-11-01

    of about 500 m in Hurricanes Allen (1980) and Hugo (1989) by Zhang et al. (2011a). In Hugo , maximum K-values were about 110 m2 s−1 beneath the eyewall...region of intense Hurricanes Allen (1980) and Hugo (1989). Mon. Wea. Rev., 139, 1447-1462. Zhang JA Rogers RF Nolan DS and Marks FD. 2011b On the...Dept. of Meteorology, Naval Postgraduate School, Monterey, CA & NOAA’s Hurricane Research Division ∗Correspondence to: Roger K. Smith, Meteorological

  4. A Goal Programming R&D (Research and Development) Project Funding Model of the U.S. Army Strategic Defense Command Using the Analytic Hierarchy Process.

    Science.gov (United States)

    1987-09-01

    A187 899 A GOAL PROGRANNIN R&D (RESEARCH AND DEVELOPMENT) 1/2 PROJECT FUNDING MODEL 0 (U) NAVAL POSTGRADUATE SCHOOL MONTEREY CA S M ANDERSON SEP 87...PROGRAMMING R&D PROJECT FUNDING MODEL OF THE U.S. ARMY STRATEGIC DEFENSE COMMAND USING THE ANALYTIC HIERARCHY PROCESS by Steven M. Anderson September 1987...jACCESSION NO TITI E (Influde Securt ClauAIcatsrn) A Goal Programming R&D Project Funding Model of the U.S. Army Strategic Defense Command Using the

  5. The Impact Analysis of a Mixed Squadron, Containing LCS and Multi-Mission Surface Platforms, on Blue Force Casualties and Mission Effectiveness

    Science.gov (United States)

    2008-09-01

    Littoral Combat Ships OTH Over-The-Horizon Pd Probability of Detection PGGF Fast Attack Craft – Missile PIM Plan of Intended Movement Pk...Lucas Naval Postgraduate School Monterey, California 2. Dudley Knox Library Naval Postgraduate School Monterey, California 3. CAPT Doug Otte

  6. Dental care for the underserved children of Monterey County: meeting the challenge.

    Science.gov (United States)

    Stewart, R E

    1998-05-01

    With its expansive area, and the special needs of agricultural workers, Monterey County held significant challenges for setting up a children's health clinic. Part of the solution to addressing the county's unmet dental needs was the establishment of the Children's Miracle Network dental center in 1995. But working in the fields leaves little time for travel to appointments, so the dental center expanded to a mobile unit that can go where the need is. Understanding the special needs of one's community is crucial to establishing programs that can successfully address the state's needs for children's dental care.

  7. Selective transport of palynomorphs in marine turbiditic deposits: An example from the Ascension-Monterey Canyon system offshore central California

    Science.gov (United States)

    McGann, Mary

    2017-01-01

    The pollen assemblage of a deep-sea core (15G) collected at lower bathyal depths (3491 m) on a levee of Monterey Canyon off central California was investigated to gain insights into the delivery processes of terrigenous material to submarine fans and the effect this transport has on the palynological record. Thirty-two samples were obtained down the length of the core, 19 from hemipelagic and mixed mud deposits considered to be the background record, and 13 others from displaced flow deposits. The pollen record obtained from the background samples documents variations in the terrestrial flora as it adapted to changing climatic conditions over the last 19,000 cal yrs BP. A Q-mode cluster analysis defined three pollen zones: a Glacial Pollen Zone (ca. 20,000–17,000 cal yr BP), an overlying Transitional Pollen Zone (ca. 17,000–11,500 cal yr BP), and an Interglacial Pollen Zone (ca. 11,500 cal yr BP to present). Another Q-mode cluster analysis, of both the background mud and flow deposits, also defined these three pollen zones, but four of the 13 turbiditic deposits were assigned to pollen zones older than expected by their stratigraphic position. This was due to these samples containing statistically significant fewer palynomorphs than the background muds as well as being enriched (∼10–35% in some cases) in hydraulically-efficient Pinus pollen. A selective bias in the pollen assemblage, such as demonstrated here, may result in incorrect interpretations (e.g., climatic shifts or environmental perturbations) based on the floral record, indicating turbiditic deposits should be avoided in marine palynological studies. Particularly in the case of fine-grained flow deposits that may not be visually distinct, granulometry and grain size frequency distribution curves may not be enough to identify these biased deposits. Determining the relative abundance and source of displaced shallow-water benthic foraminifera entrained in these sediments serves as an excellent

  8. A Vision in Progress. The Decision To Establish a Public University at Monterey Bay. An Occasional Paper.

    Science.gov (United States)

    Chance, William

    This report describes the decision-making process and problems encountered during the 48 months it took to establish a new university, California State University at Monterey Bay, on the site of Fort Ord, a recently closed military base. After an introduction, the report is organized in four sections, one for each phase of the process. The first…

  9. The Advantages and Disadvantages of Converting the Naval Postgraduate School to a Navy Working Capital Fund Activity

    Science.gov (United States)

    2014-06-01

    government agencies, and a number of international partners across the globe. In addition to providing advanced educational opportunities, NPS also offers a...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT THE ADVANTAGES AND DISADVANTAGES OF CONVERTING THE NAVAL...USE ONLY (Leave blank) 2. REPORT DATE June 2014 3. REPORT TYPE AND DATES COVERED MBA Professional Report 4. TITLE AND SUBTITLE THE ADVANTAGES AND

  10. 77 FR 73322 - Revisions to the California State Implementation Plan, Monterey Bay Unified Air Pollution Control...

    Science.gov (United States)

    2012-12-10

    ...EPA is taking direct final action to approve revisions to the Monterey Bay Unified Air Pollution Control District (MBUAPCD) portion of the California State Implementation Plan (SIP). These revisions concern opacity standards related to multiple pollutants, including particulate matter (PM) emissions from several different types of sources, ranging from fugitive dust to gas turbines. We are approving a local rule that regulates these emission sources under the Clean Air Act (CAA or the Act).

  11. 77 FR 73392 - Revisions to the California State Implementation Plan, Monterey Bay Unified Air Pollution Control...

    Science.gov (United States)

    2012-12-10

    ...EPA is proposing to approve revisions to the Monterey Bay Unified Air Pollution Control District (MBUAPCD) portion of the California State Implementation Plan (SIP). This revision concerns opacity standards related to multiple pollutants, including particulate matter (PM) emissions from several different types of sources, ranging from fugitive dust to gas turbines. We are proposing to approve a local rule to regulate these emission sources under the Clean Air Act (CAA or the Act).

  12. Repeat Mapping in the Lower Monterey Submarine Canyon Sheds Light on Morphological Change During Discrete Sediment Density Flow Events

    Science.gov (United States)

    Anderson, K.; Lundsten, E. M.; Caress, D. W.; Thomas, H. J.; Paull, C. K.; Maier, K. L.; Gales, J. A.; Gwiazda, R.; Talling, P.; Xu, J.; Parsons, D. R.

    2017-12-01

    The Coordinated Canyon Experiment (CCE), a multi-institutional collaboration effort, was designed to monitor the passage of sediment density flows along the axis of Monterey Canyon, offshore California, between 200 and 1850 m water depth. An array of moorings and sensors were deployed for three 6-month periods from October 2015 to April 2017. Aligned with the CCE deployments, repeat high-resolution multibeam bathymetric surveys of the Monterey Canyon floor were conducted with a mapping AUV (Autonomous Underwater Vehicle). The AUV carried a Reson 7125 multibeam echosounder (vertical precision of 0.15 m and horizontal resolution of 1.0 m). An inertial navigation system combined with a Doppler velocity logger allowed the AUV to fly pre-programmed grids at 3 knots, while maintaining an altitude of 50 m above the seafloor, to obtain a nominal line spacing of 130 m. The floor and lower flanks of the canyon between 200 to 540 m and 1350 to 1880 m water depths were mapped six times during the CCE. These repeat maps are subtracted to create bathymetry difference grids to show morphological change. Coupling the sensor observations with the bathymetric surveys, the CCE successfully documented sediment density flow events as well as the associated changes in seafloor morphology. Between repeat surveys, three sediment density flow events reached the lower canyon, extending to at least 1850 m water depth. On January 15, 2016, a particularly large density flow traveled more than 50 km down Monterey Canyon. Unlike in the upper canyon where this event caused wholesale reorganization of geomorphological features, changes to the lower canyon morphology involved a more moderate re-sculpting of the features. The effect of a sediment density flow of known magnitude and duration on the seafloor morphology has never been documented in a deep-sea setting before.

  13. 75 FR 37727 - Disapproval of California State Implementation Plan Revisions, Monterey Bay Unified Air Pollution...

    Science.gov (United States)

    2010-06-30

    ...EPA is finalizing disapproval of a revision to the Monterey Bay Unified Air Pollution Control District (MBUAPCD) portion of the California State Implementation Plan (SIP). This action was proposed in the Federal Register on March 22, 2010. This revision concerns opacity standards related to multiple pollutants, including particulate matter (PM) emissions, from a wide variety of sources. Under authority of the Clean Air Act as amended in 1990 (CAA or the Act), this action identifies a deficiency that precludes approval of this SIP revision.

  14. Using XML/HTTP to Store, Serve and Annotate Tactical Scenarios for X3D Operational Visualization and Anti-Terrorist Training

    Science.gov (United States)

    2003-03-01

    PXSLServlet Paul A. Open Source Relational x X 23 Tchistopolskii sql2dtd David Mertz Public domain Relational x -- sql2xml Scott Hathaway Public...March 2003. [Hunter 2001] Hunter, David ; Cagle, Kurt; Dix, Chris; Kovack, Roger; Pinnock, Jonathan, Rafter, Jeff; Beginning XML (2nd Edition...Postgraduate School Monterey, California 4. Curt Blais Naval Postgraduate School Monterey, California 5 Erik Chaum NAVSEA Undersea

  15. Implementing Replacement Cost Accounting

    Science.gov (United States)

    1976-12-01

    cost accounting Clickener, John Ross Monterey, California. Naval Postgraduate School http://hdl.handle.net/10945/17810 Downloaded from NPS Archive...Calhoun IMPLEMENTING REPLACEMENT COST ACCOUNTING John Ross CHckener NAVAL POSTGRADUATE SCHOOL Monterey, California THESIS IMPLEMENTING REPLACEMENT COST ...Implementing Replacement Cost Accounting 7. AUTHORS John Ross Clickener READ INSTRUCTIONS BEFORE COMPLETING FORM 3. RECIPIENT’S CATALOG NUMBER 9. TYRE OF

  16. 75 FR 13468 - Disapproval of California State Implementation Plan Revisions, Monterey Bay Unified Air Pollution...

    Science.gov (United States)

    2010-03-22

    ...EPA is proposing to disapprove a revision to the Monterey Bay Unified Air Pollution Control District (MBAPCD) portion of the California State Implementation Plan (SIP). This revision concerns opacity standards related to multiple pollutants, including particulate matter (PM) emissions from several different types of sources, ranging from fugitive dust to gas turbine generators. We are proposing action on a local rule that regulates these emission sources under the Clean Air Act as amended in 1990 (CAA or the Act). We are taking comments on this proposal and plan to follow with a final action.

  17. The timing of sediment transport down Monterey Submarine Canyon, offshore California

    DEFF Research Database (Denmark)

    Stevens, Thomas; Paull, C.K.; Ussler, W., III

    2014-01-01

    luminescence (OSL) ages of quartz sand deposits and accelerator mass spectrometry 14C ages measured on benthic foraminifera to examine the timing of sediment transport through the axial channel of Monterey Submarine Canyon and Fan, offshore California. The OSL ages date the timing of sediment entry...... dates with water depth provides evidence of mixing and temporary storage of sediment as it moves through the canyon system. The ages also indicate that the frequency of sediment transport events decreases with distance down the canyon channel system. The amalgamated sands near the canyon head yield OSL......While submarine canyons are the major conduits through which sediments are transported from the continents out into the deep sea, the time it takes for sediment to pass down through a submarine canyon system is poorly constrained. Here we report on the first study to couple optically stimulated...

  18. Connecting an Ocean-Bottom Broadband Seismometer to a Seafloor Cabled Observatory: A Prototype System in Monterey Bay

    Science.gov (United States)

    McGill, P.; Neuhauser, D.; Romanowicz, B.

    2008-12-01

    The Monterey Ocean-Bottom Broadband (MOBB) seismic station was installed in April 2003, 40 km offshore from the central coast of California at a seafloor depth of 1000 m. It comprises a three-component broadband seismometer system (Guralp CMG-1T), installed in a hollow PVC caisson and buried under the seafloor; a current meter; and a differential pressure gauge. The station has been operating continuously since installation with no connection to the shore. Three times each year, the station is serviced with the aid of a Remotely Operated Vehicle (ROV) to change the batteries and retrieve the seismic data. In February 2009, the MOBB system will be connected to the Monterey Accelerated Research System (MARS) seafloor cabled observatory. The NSF-funded MARS observatory comprises a 52 km electro-optical cable that extends from a shore facility in Moss Landing out to a seafloor node in Monterey Bay. Once installation is completed in November 2008, the node will provide power and data to as many as eight science experiments through underwater electrical connectors. The MOBB system is located 3 km from the MARS node, and the two will be connected with an extension cable installed by an ROV with the aid of a cable-laying toolsled. The electronics module in the MOBB system is being refurbished to support the connection to the MARS observatory. The low-power autonomous data logger has been replaced with a PC/104 computer stack running embedded Linux. This new computer will run an Object Ring Buffer (ORB), which will collect data from the various MOBB sensors and forward it to another ORB running on a computer at the MARS shore station. There, the data will be archived and then forwarded to a third ORB running at the UC Berkeley Seismological Laboratory. Timing will be synchronized among MOBB's multiple acquisition systems using NTP, GPS clock emulation, and a precise timing signal from the MARS cable. The connection to the MARS observatory will provide real-time access to

  19. Visible Spectrum of Stable Sonoluminescence

    Science.gov (United States)

    1992-12-01

    Lawrence Livermore National Laboratory. 9. Interview between Dr. David S. Davis, Physics Department, Naval Postgraduate School, Monterey California, and the...December 1992. 11. B. P. Barber, R. Hiller, K. Arisaka, H. Fetterman , and S. J. Putterman, "Resolving the picosecond characteristics of synchronous...author, 12 November 1992. 14. Interview between Dr. David S. Davis, Physics Department, Naval Postgraduate School, Monterey California, and the author, 14

  20. Seismic stratigraphy and late Quaternary shelf history, south-central Monterey Bay, California

    Science.gov (United States)

    Chin, J.L.; Clifton, H.E.; Mullins, H.T.

    1988-01-01

    The south-central Monterey Bay shelf is a high-energy, wave-dominated, tectonically active coastal region on the central California continental margin. A prominent feature of this shelf is a sediment lobe off the mouth of the Salinas River that has surface expression. High-resolution seismic-reflection profiles reveal that an angular unconformity (Quaternary?) underlies the entire shelf and separates undeformed strata above it from deformed strata below it. The Salinas River lobe is a convex bulge on the shelf covering an area of approximately 72 km2 in water depths from 10 to 90 m. It reaches a maximum thickness of 35 m about 2.5 km seaward of the river mouth and thins in all directions away from this point. Adjacent shelf areas are characterized by only a thin (2 to 5 m thick) and uniform veneer of sediment. Acoustic stratigraphy of the lobe is complex and is characterized by at least three unconformity-bounded depositional sequences. Acoustically, these sequences are relatively well bedded. Acoustic foresets occur within the intermediate sequence and dip seaward at 0.7?? to 2.0??. Comparison with sedimentary sequences in uplifted onshore Pleistocene marine-terrace deposits of the Monterey Bay area, which were presumably formed in a similar setting under similar processes, suggests that a general interpretation can be formulated for seismic stratigraphic patterns. Depositional sequences are interpreted to represent shallowing-upwards progradational sequences of marine to nonmarine coastal deposits formed during interglacial highstands and/or during early stages of falling sea level. Acoustic foresets within the intermediate sequence are evidence of seaward progradation. Acoustic unconformities that separate depositional sequences are interpreted as having formed largely by shoreface planation and may be the only record of the intervening transgressions. The internal stratigraphy of the Salinas River lobe thus suggests that at least several late Quaternary

  1. Groundwater quality in the shallow aquifers of the Monterey Bay, Salinas Valley, and adjacent highland areas, California

    Science.gov (United States)

    Burton, Carmen

    2018-05-30

    Groundwater provides more than 40 percent of California’s drinking water. To protect this vital resource, the State of California created the Groundwater Ambient Monitoring and Assessment (GAMA) Program. The Priority Basin Project of the GAMA Program provides a comprehensive assessment of the State’s groundwater quality and increases public access to groundwater-quality information. The shallow aquifers of the groundwater basins around Monterey Bay, the Salinas Valley, and the highlands adjacent to the Salinas Valley constitute one of the study units.

  2. Isotope systematic of contaminant leads in Monterey Bay

    International Nuclear Information System (INIS)

    Flegal, A.R.; Rosman, K.J.R.; Stephenson, M.D.

    1987-01-01

    Isotopic compositions of stable lead ( 204 Pb, 206 Pb, 207 Pb, and 208 Pb) were utilized to identify a lead slag deposit as the principal source of contaminant lead in Monterey Bay. This point source had been indicated by anomalously high lead concentrations in native mussels (Mytilus californianus) near that deposit, which were orders of magnitude above the base-line concentration of the species (0.5 μg/g). Subsequent analyses revealed that the lead concentrations of both transplanted mussels and intertidal sediments were positively correlated with their proximity to the slag deposit. Complementary lead isotopic compositions substantiated those empirical correlations by demonstrating that the slag was the predominant source of contaminant lead in both the mussels and the sediments. Analyses of the digestive tracts of mussels from the slag deposit indicated that ingested slag particulates accounted for their elevated lead concentrations, while analyses of their gonads indicated that dissolved lead from other industrial sources was also being bioaccumulated by passive adsorption on exposed surfaces. Therefore, this study has demonstrated the potential of lead isotope systematics both to identify sources of lead contamination in marine organisms and to trace its biogeochemical cycle in the marine environment. 26 references, 3 figures, 5 tables

  3. The application of NAA and ASS techniques on determination of daily dietary intake of Ca, Fe and Zn in school-aged children in Bandung city

    International Nuclear Information System (INIS)

    Widya Dwi Ariyani; Katharina Oginawati; Muhayatun Santoso; Diah Dwiana L; Endah Damastuti; Syukria Kurniawati; Natalia Adventini; Woro Yatu Niken S

    2011-01-01

    Micronutrient elements contained in foods have an important role in the metabolism process in human body, so micronutrient element deficiencies can cause health problems and chronic diseases. Children are the population that generally more vulnerable in suffering of micronutrient deficiencies which have significant affects on their growth and development. Micronutrient deficiencies have long been happening in Indonesia but were not solved and the nutrition status data of children in Indonesia is still limited. Therefore, through this research the daily dietary intake of Ca, Fe and Zn micronutrient in school-aged children has been determined. Food sampling was carried out using duplicate diet method and the Fe and Zn elements were determined using Neutron Activation Analysis (NAA) while the Ca was determined using Atomic Absorption Spectrometry (AAS) method. The analysis results show the range concentration of Ca, Fe and Zn in food samples obtained were 307-1991; 10,1-95,5 and 11,9-29,4 mg/kg respectively, while the average of Ca, Fe and Zn daily intake were 228; 9.3 and 4.6 mg/day and they were only fulfill 28%, 74% and 39% of AKG (adequate value of nutrient). The Ca, Fe and Zn deficiencies were observed on school-aged children in Bandung. This result is expected to give description and information to the authority on planning and policies taking as efforts in quality improvement of the next human resources. (author)

  4. Direct sampling during multiple sediment density flows reveals dynamic sediment transport and depositional environment in Monterey submarine canyon

    Science.gov (United States)

    Maier, K. L.; Gales, J. A.; Paull, C. K.; Gwiazda, R.; Rosenberger, K. J.; McGann, M.; Lundsten, E. M.; Anderson, K.; Talling, P.; Xu, J.; Parsons, D. R.; Barry, J.; Simmons, S.; Clare, M. A.; Carvajal, C.; Wolfson-Schwehr, M.; Sumner, E.; Cartigny, M.

    2017-12-01

    Sediment density flows were directly sampled with a coupled sediment trap-ADCP-instrument mooring array to evaluate the character and frequency of turbidity current events through Monterey Canyon, offshore California. This novel experiment aimed to provide links between globally significant sediment density flow processes and their resulting deposits. Eight to ten Anderson sediment traps were repeatedly deployed at 10 to 300 meters above the seafloor on six moorings anchored at 290 to 1850 meters water depth in the Monterey Canyon axial channel during 6-month deployments (October 2015 - April 2017). Anderson sediment traps include a funnel and intervalometer (discs released at set time intervals) above a meter-long tube, which preserves fine-scale stratigraphy and chronology. Photographs, multi-sensor logs, CT scans, and grain size analyses reveal layers from multiple sediment density flow events that carried sediment ranging from fine sand to granules. More sediment accumulation from sediment density flows, and from between flows, occurred in the upper canyon ( 300 - 800 m water depth) compared to the lower canyon ( 1300 - 1850 m water depth). Sediment accumulated in the traps during sediment density flows is sandy and becomes finer down-canyon. In the lower canyon where sediment directly sampled from density flows are clearly distinguished within the trap tubes, sands have sharp basal contacts, normal grading, and muddy tops that exhibit late-stage pulses. In at least two of the sediment density flows, the simultaneous low velocity and high backscatter measured by the ADCPs suggest that the trap only captured the collapsing end of a sediment density flow event. In the upper canyon, accumulation between sediment density flow events is twice as fast compared to the lower canyon; it is characterized by sub-cm-scale layers in muddy sediment that appear to have accumulated with daily to sub-daily frequency, likely related to known internal tidal dynamics also measured

  5. Arsenic Removal from Drinking Water by Adsorptive Media U.S. EPA Demonstration Project at Richmond Elementary School in Susanville, CA Final Performance Evaluation Report

    Science.gov (United States)

    This report documents the activities performed and the results obtained for the arsenic removal treatment technology demonstration project at Richmond Elementary School in Susanville, CA. The objectives of the project were to evaluate: (1) the effectiveness of an Aquatic Treatme...

  6. Rare earth, major, and trace element composition of Monterey and DSDP chert and associated host sediment: Assessing the influence of chemical fractionation during diagenesis

    Science.gov (United States)

    Murray, R.W.; Buchholtz ten Brink, Marilyn R.; Gerlach, David C.; Russ III, G. Price; Jones, David L.

    1992-01-01

    Chert and associated host sediments from Monterey Formation and Deep Sea Drilling Project (DSDP) sequences were analyzed in order to assess chemical behavior during diagenesis of biogenic sediments. The primary compositional contrast between chert and host sediment is a greater absolute SiO2 concentration in chert, often with final SiO2 ≥ 98 wt%. This contrast in SiO2 (and SiAl">SiAl) potentially reflects precursor sediment heterogeneity, diagenetic chemical fractionation, or both. SiO2 concentrations and SiAl">SiAl ratios in chert are far greater than in modern siliceous oozes, however and often exceed values in acid-cleaned diatom tests. Compositional contrasts between chert and host sediment are also orders-of-magnitude greater than between multiple samples of the host sediment. Calculations based on the initial composition of adjacent host, observed porosity reductions from host to chert and a postulated influx of pure SiO2, construct a chert composition which is essentially identical to observed SiO2 values in chert. Thus, precursor heterogeneity does not seem to be the dominant factor influencing the current chert composition for the key elements of interest. In order to assess the extent of chemical fractionation during diagenesis, we approximate the precursor composition by analyzing host sediments adjacent to the chert.The SiO2 concentration contrast seems caused by biogenic SiO2 dissolution and transport from the local adjacent host sediment and subsequent SiO2reprecipitation in the chert. Along with SiO2, other elements are often added (with respect to Al) to Monterey and DSDP chert during silicification, although absolute concentrations decrease. The two Monterey quartz chert nodules investigated, in contrast to the opal-CT and quartz chert lenses, formed primarily by extreme removal of carbonate and phosphate, thereby increasing relative SiO2 concentrations. DSDP chert formed by both carbonate/phosphate dissolution and SiO2 addition from

  7. New Methods for the Detection and Interception of Frequency-Hopped Waveforms

    Science.gov (United States)

    1990-11-01

    that £[p2 Q2 /O] = uF + 2 + o(cos 0 + 6 sin9)2 + 4n(acos0+/3sin)(7ycos0+6sinO)+o r(acos0+sinO)2 I + ( acosO +/3sinO) 2(Tcos9+ 6sin O)2 (3.134) i which...Jcins I lopk ins lI mvtrsi! t3 A pplied Physics Laborator Before1 NII After Figure 4.4: Deconvolut ion Applivod to Oi-fFci i r 100 The Johns 11opkins...Arlington, VA 20360 Library 2 Naval Postgraduate School Monterey, CA 92940 Library 2 Naval Research Laborator . Washington, DC 20375 Library 2 J. W

  8. IMET Feasibility Study and Implementation: Maximizing the Graduate School of Business and Public Policy Experience for International Students at the Naval Postgraduate School

    Science.gov (United States)

    2006-06-01

    commented: Most of materials will be available for only one country. Singaporeans do not understand German, I do not read French etc. Information...informed about restaurants and supermarkets offering international cuisine or even cuisine from their country in the Monterey area. The majority of the...restaurants and supermarkets offering international cuisine , or even cuisine from their country, in the Monterey area through the welcome package

  9. Agent-Based Simulation and Analysis of a Defensive UAV Swarm Against an Enemy UAV Swarm

    Science.gov (United States)

    2011-06-01

    energy options” [10]. The research of swarm robotics derives much of its inspiration from natural systems. Social insects are known to coordinate their...Monterey, California 9. CPT. Francisco J. Hederra Direccion de Investigacion, Programas y Desarrollo de la Armada Armada de Chile CHILE 10. CAPT Jeffrey Kline, USN(ret.) Naval Postgraduate School Monterey, California 91

  10. K-12 Local Network (LAN) Design Guide

    National Research Council Canada - National Science Library

    Horton, Cody

    1998-01-01

    ...) educators preparing to design and implement LANs in K-12 schools and libraries. Data was collected during the implementation of LANs in K-12 schools of the Monterey Peninsula Uniform School District (MPUSD...

  11. 76 FR 76411 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-12-07

    ... Avenue, Apt. A, Monterey Park, CA 91755-2044, Officers: Li Lin, General Manager/Sec/CFO, (Qualifying.... Suddath Global Logistics, LLC dba Suddath Global Logistics, (NVO & OFF), 815 South Main Street...

  12. Seven years of geomorphic change in the head of Monterey Canyon, CA: Steady state equilibrium or monotonic change?

    Science.gov (United States)

    Smith, D. P.; Kvitek, R. G.; Ross, E.; Iampietro, P.; Paull, C. K.; Sandersfeld, M.

    2010-12-01

    The head of Monterey submarine canyon has been surveyed with high-precision multibeam sonar at least once each year since September 2002. This poster provides a summary of changes between September 2002 and September 2008. Data were collected with a variety of Reson mulitbeam sonar heads, and logged with an ISIS data acquisition system. Vessel attitude was corrected using an Applanix POS MV equipped with an auxillary C-Nav 2050 GPS receiver. Data were processed and filtered and cleaned in Caris HIPS. Depth changes for various time spans were determined through raster subtraction of pairs of 3-m resolution bathymetric grids in ArcMap. The depth change analyses focused on the canyon floor, except where a landslide occurred on a wall, and where obvious gullying near the headwall had occurred during the time of our study. Canyon walls were generally excluded from analysis. The analysis area was 1,414,240 sq meters. The gross changes between 2002 and 2008 include net erosion of 2,300,000 m^3 +/- 800,000 m^3 of material from the canyon. The annualized rate of net sediment loss from this time frame agrees within an order of magnitude with our previously published estimates from earlier (shorter) time frames, so the erosion events seem to be moderate magnitude and frequent, rather than infrequent and catastrophic. The greatest sediment loss appears to be from lateral erosion of channel-bounding terraces rather than deepening or scouring of the existing channel axis. A single landslide event that occurred in summer 2003 had an initial slide scar (void) volume of 71,000 m^3. The scar was observed to increase annually, and had grown to approximately 96,000 m^3 by 2008. The initial slide was too small to be tsunamigenic. In contrast to the monotonic canyon axis widening, the shoreward terminus of the canyon (canyon lip) appears to be in steady state equilibrium with sediment supply entering the canyon from the littoral zone. The lip position, indicated by the clearly defined

  13. U.S. Directory of Marine Scientists 1982

    Science.gov (United States)

    1982-01-01

    Processes & Engineering. MACLEAN, SHARON A, Fishery Biologist. FINKELSTEIN, KENNETH, Coastal Geologist. Zooplankton; Crustacea. Sedimentology; Stratigraphy... SHARON T, Aszt Scientist. Pasadena, CA 91109 Taxonomy and Systematics; Zooplankton. HOWEY, TERRY W, Scientist. CHELTON, DUDLEY BOYD, JR, Senior...Oceanography. Monterey, CA 93940 Optics; Descriptive Physical Oceanography, Instrumentation Engineering. BOURKE , ROBERT H, Assoc Professor of VON SCHWIND

  14. Environmental Impact Analysis Process. Environmental Assessment Air Force Small Launch Vehicle, Vandenberg Air Force Base, Edwards Air Force Base, and San Nicolas Island, CA

    Science.gov (United States)

    1991-05-01

    abundant throughout the Monterey Formation (Dibblee, 1950). Monterey rocks can also yield whale bones, fish fragments, insects , crabs, algae imprints...Carpobrotus edulis), rosilla (Helenium puberulum), coyote bush, and giant creek nettle (Urtica holosericea) (USAF, 1980). The existence of M. crispa...habitat for wildlife in Spring Canyon. Eucalyptus flowers produce large quantities of nectar, which is utilized by numerous insects and birds

  15. Long-term cliff retreat and erosion hotspots along the central shores of the Monterey Bay National Marine Sanctuary

    Science.gov (United States)

    Moore, Laura J.; Griggs, Gary B.

    2002-01-01

    Quantification of cliff retreat rates for the southern half of Santa Cruz County, CA, USA, located within the Monterey Bay National Marine Sanctuary, using the softcopy/geographic information system (GIS) methodology results in average cliff retreat rates of 7–15 cm/yr between 1953 and 1994. The coastal dunes at the southern end of Santa Cruz County migrate seaward and landward through time and display net accretion between 1953 and 1994, which is partially due to development. In addition, three critically eroding segments of coastline with high average erosion rates ranging from 20 to 63 cm/yr are identified as erosion ‘hotspots’. These locations include: Opal Cliffs, Depot Hill and Manresa. Although cliff retreat is episodic, spatially variable at the scale of meters, and the factors affecting cliff retreat vary along the Santa Cruz County coastline, there is a compensation between factors affecting retreat such that over the long-term the coastline maintains a relatively smooth configuration. The softcopy/GIS methodology significantly reduces errors inherent in the calculation of retreat rates in high-relief areas (e.g. erosion rates generated in this study are generally correct to within 10 cm) by removing errors due to relief displacement. Although the resulting root mean squared error for erosion rates is relatively small, simple projections of past erosion rates are inadequate to provide predictions of future cliff position. Improved predictions can be made for individual coastal segments by using a mean erosion rate and the standard deviation as guides to future cliff behavior in combination with an understanding of processes acting along the coastal segments in question. This methodology can be applied on any high-relief coast where retreat rates can be measured.

  16. Seasonal and Inter-Annual Patterns of Phytoplankton Community Structure in Monterey Bay, CA Derived from AVIRIS Data During the 2013-2015 HyspIRI Airborne Campaign

    Science.gov (United States)

    Palacios, S. L.; Thompson, D. R.; Kudela, R. M.; Negrey, K.; Guild, L. S.; Gao, B. C.; Green, R. O.; Torres-Perez, J. L.

    2015-12-01

    There is a need in the ocean color community to discriminate among phytoplankton groups within the bulk chlorophyll pool to understand ocean biodiversity, to track energy flow through ecosystems, and to identify and monitor for harmful algal blooms. Imaging spectrometer measurements enable use of sophisticated spectroscopic algorithms for applications such as differentiating among coral species, evaluating iron stress of phytoplankton, and discriminating phytoplankton taxa. These advanced algorithms rely on the fine scale, subtle spectral shape of the atmospherically corrected remote sensing reflectance (Rrs) spectrum of the ocean surface. As a consequence, these algorithms are sensitive to inaccuracies in the retrieved Rrs spectrum that may be related to the presence of nearby clouds, inadequate sensor calibration, low sensor signal-to-noise ratio, glint correction, and atmospheric correction. For the HyspIRI Airborne Campaign, flight planning considered optimal weather conditions to avoid flights with significant cloud/fog cover. Although best suited for terrestrial targets, the Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) has enough signal for some coastal chlorophyll algorithms and meets sufficient calibration requirements for most channels. However, the coastal marine environment has special atmospheric correction needs due to error that may be introduced by aerosols and terrestrially sourced atmospheric dust and riverine sediment plumes. For this HyspIRI campaign, careful attention has been given to the correction of AVIRIS imagery of the Monterey Bay to optimize ocean Rrs retrievals for use in estimating chlorophyll (OC3 algorithm) and phytoplankton functional type (PHYDOTax algorithm) data products. This new correction method has been applied to several image collection dates during two oceanographic seasons - upwelling and the warm, stratified oceanic period for 2013 and 2014. These two periods are dominated by either diatom blooms (occasionally

  17. Oceanographic data collected during the Davidson Seamount 2002 expedition on the RV Western Flyer, in the North Pacific Ocean, southwest of Monterey, California from May 17, 2002 - May 24, 2002 (NODC Accession 0072306)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This spring, scientists explored the first "undersea island" to be called a seamount. Davidson seamount, located 120 km Southwest of Monterey, California, is one of...

  18. Study of Navy Enlisted Attrition: Race, Ethnicity, and Type of Occupation

    National Research Council Canada - National Science Library

    Carroll, James M

    2008-01-01

    .... The study uses a special database developed by the Defense Manpower Data Center in Monterey, CA, that contains the records of 186,938 male recruits who enlisted in the Navy during calendar years 1996 through 2000...

  19. Cost-effectiveness of a school-based health promotion program in Canada: A life-course modeling approach.

    Directory of Open Access Journals (Sweden)

    John Paul Ekwaru

    Full Text Available The Alberta Project Promoting active Living and healthy Eating in Schools (APPLE Schools has been recognized as a "best practice" in preventing childhood obesity. To inform decision making on the economic implications of APPLE Schools and to justify investment, we evaluated the project's cost-effectiveness following a life-course approach.We developed a state transition model for the lifetime progression of body weight status comparing elementary school students attending APPLE Schools and control schools. This model quantified the lifetime impact of APPLE Schools in terms of prevention of excess body weight, chronic disease and improved quality-adjusted life years (QALY, from a school system's cost perspective. Both costs and health outcomes were discounted to their present value using 3% discount rate.The incremental cost-effectiveness ratio(ICER of APPLE schools was CA$33,421 per QALY gained, and CA$1,555, CA$1,709 and CA$14,218 per prevented person years of excess weight, obesity and chronic disease, respectively. These estimates show that APPLE Schools is cost effective at a threshold of ICER < CA$50,000. In probabilistic sensitivity analysis, APPLE Schools was cost effective more than 64% of the time per QALY gained, when using a threshold of ICER<CA$50,000, and more than 93% of the time when using a threshold of ICER<CA$100,000.School-based health promotion, such as APPLE Schools is a cost-effective intervention for obesity prevention and reduction of chronic disease risk over the lifetime. Expanding the coverage and allocating resources towards school-based programs like the APPLE Schools program, is likely to reduce the public health burden of obesity and chronic diseases.

  20. Repeated 1-cm Resolution Topographic and 2.5-mm Resolution Photomosiac Surveys of Benthic Communities and Fine Scale Bedforms in Monterey Canyon

    Science.gov (United States)

    Caress, D. W.; Hobson, B.; Thomas, H. J.; Henthorn, R.; Martin, E. J.; Bird, L.; Risi, M.; Troni, G.; Paull, C. K.; Rock, S.; Padial, J. A.; Hammond, M. M.

    2014-12-01

    The Monterey Bay Aquarium Research Institute has developed a low altitude, ROV-based seafloor mapping system that combines lidar laser ranging, multibeam sonar, and stereo photographic imagery. When operated at a 3-m altitude, this system maps seafloor topography with a 1-cm lateral resolution and simultaneously collects 2.5-mm resolution color photography. We have twice mapped an 80-m by 80-m area of a chemosynthetic clam community located at 2850-m depth in the Monterey Canyon axis. Both the topography and the photomosaics resolve changes in the clam community over a six-month interval. Many individual animals have moved, and tracks of those animals are visible in the lidar topography. No other changes in the seafloor at this site can be discerned. We have also performed single surveys of bedforms and scours at both 1850-m and 2850-m depths in Monterey Canyon. The highest resolution bathymetry data are collected using a 3DatDepth SL1 lidar laser scanner. This system has a 30° field of view and ranges continuously, achieving a 1 cm sounding spacing at a 3 m altitude and 0.3 m/s speed. Bathymetry data are also collected using a 400-kHz Reson 7125 multibeam sonar. This configuration produces 512 beams across a 135° wide swath; each beam has a 0.5° acrosstrack by 1.0° alongtrack angular width. At a 3-m altitude, the nadir beams have a 2.5 cm acrosstrack and 5 cm alongtrack footprint. Dual Prosilica GX1920 2.4 Mpixel color cameras provide color stereo photography of the seafloor. Illumination is provided by dual xenon strobes. The camera housings have been fitted with corrective optics achieving a 90° field of view with less than 1% distortion. At a 3-m altitude the raw image pixels have a 2.5 mm resolution. Position and attitude data are provided by a Kearfott SeaDevil Inertial Navigation System (INS) integrated with a 300 kHz Teledyne RD Instruments Doppler velocity log (DVL). A separate Paroscientific pressure sensor is mounted adjacent to the INS. The INS

  1. Diagenetic and compositional controls of wettability in siliceous sedimentary rocks, Monterey Formation, California

    Science.gov (United States)

    Hill, Kristina M.

    Modified imbibition tests were performed on 69 subsurface samples from Monterey Formation reservoirs in the San Joaquin Valley to measure wettability variation as a result of composition and silica phase change. Contact angle tests were also performed on 6 chert samples from outcrop and 3 nearly pure mineral samples. Understanding wettability is important because it is a key factor in reservoir fluid distribution and movement, and its significance rises as porosity and permeability decrease and fluid interactions with reservoir grain surface area increase. Although the low permeability siliceous reservoirs of the Monterey Formation are economically important and prolific, a greater understanding of factors that alter their wettability will help better develop them. Imbibition results revealed a strong trend of decreased wettability to oil with increased detrital content in opal-CT phase samples. Opal-A phase samples exhibited less wettability to oil than both opal-CT and quartz phase samples of similar detrital content. Subsurface reservoir samples from 3 oil fields were crushed to eliminate the effect of capillary pressure and cleansed of hydrocarbons to eliminate wettability alterations by asphaltene, then pressed into discs of controlled density. Powder discs were tested for wettability by dispensing a controlled volume of water and motor oil onto the surface and measuring the time required for each fluid to imbibe into the sample. The syringe and software of a CAM101 tensiometer were used to control the amount of fluid dispensed onto each sample, and imbibition completion times were determined by high-speed photography for water drops; oil drop imbibition was significantly slower and imbibition was timed and determined visually. Contact angle of water and oil drops on polished chert and mineral sample surfaces was determined by image analysis and the Young-Laplace equation. Oil imbibition was significantly slower with increased detrital composition and faster

  2. The elements of a consumer-based initiative in contributing to positive environmental change: Monterey Bay Aquarium's Seafood Watch program.

    Science.gov (United States)

    Kemmerly, Jennifer Dianto; Macfarlane, Victoria

    2009-09-01

    Monterey Bay Aquarium launched the Seafood Watch program in 2000. The program's Seafood Watch pocket guide is a simple tool that visitors can use to identify seafood from environmentally responsible sources. Since its inception, more than 2 million pocket guides have been distributed to Monterey Bay Aquarium visitors and 20 million have been distributed through partnerships across the United States. Partner institutions such as aquariums, conservation organizations, and businesses also conduct outreach and are working to influence their local seafood purveyors. An evaluation conducted in 2003 and 2004 assessed the program's strategies for increasing awareness and shifting consumer buying habits as they relate to sustainable seafood, including use of the pocket guide. Visitors who picked up pocket guides were surveyed immediately after their aquarium visit, and again four months later. The evaluation found that most visitors continued to use the guides and had changed their seafood buying habits in several respects. Those interviewed also reported some barriers to using the guides. The elements that appear to be critical to the success of the strategy with respect to changing consumer purchasing habits include: a focused distribution approach; providing credible and specific information on problems and solutions to increase action-related knowledge; providing a trigger or prompt that is available at the time of purchase; and reducing barriers to action, at the point of action, by working with seafood purveyors and the broader sustainable seafood movement to increase knowledge and available options. In response to the evaluation, Seafood Watch has strengthened these elements and expanded to help meet the needs of the broader sustainable seafood movement. A process of strategic planning, evaluation, cooperation among partners, and adaptability to the movement's natural evolution has proven to be critical to the program's success in contributing to the development of a

  3. Seasonal and Inter-Annual Patterns of Chlorophyll and Phytoplankton Community Structure in Monterey Bay, CA Derived from AVIRIS Data During the 2013-2015 HyspIRI Airborne Campaign

    Science.gov (United States)

    Palacios, S. L.; Thompson, D. R.; Kudela, R. M.; Negrey, K.; Guild, L. S.; Gao, B. C.; Green, R. O.; Torres-Perez, J. L.

    2016-02-01

    There is a need in the ocean color community to discriminate among phytoplankton groups within the bulk chlorophyll pool to understand ocean biodiversity, track energy flow through ecosystems, and identify and monitor for harmful algal blooms. Imaging spectrometer measurements enable the use of sophisticated spectroscopic algorithms for applications such as differentiating among coral species and discriminating phytoplankton taxa. These advanced algorithms rely on the fine scale, subtle spectral shape of the atmospherically corrected remote sensing reflectance (Rrs) spectrum of the ocean surface. Consequently, these algorithms are sensitive to inaccuracies in the retrieved Rrs spectrum that may be related to the presence of nearby clouds, inadequate sensor calibration, low sensor signal-to-noise ratio, glint correction, and atmospheric correction. For the HyspIRI Airborne Campaign, flight planning considered optimal weather conditions to avoid flights with significant cloud/fog cover. Although best suited for terrestrial targets, the Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) has enough signal for some coastal chlorophyll algorithms and meets sufficient calibration requirements for most channels. The coastal marine environment has special atmospheric correction needs due to error introduced by aerosols and terrestrially sourced atmospheric dust and riverine sediment plumes. For this HyspIRI campaign, careful attention has been given to the correction of AVIRIS imagery of the Monterey Bay to optimize ocean Rrs retrievals to estimate chlorophyll (OC3) and phytoplankton functional type (PHYDOTax) data products. This new correction method has been applied to several image collection dates during two oceanographic seasons in 2013 and 2014. These two periods are dominated by either diatom blooms or red tides. Results to be presented include chlorophyll and phytoplankton community structure and in-water validation data for these dates during the two seasons.

  4. Carbon-isotope stratigraphy from terrestrial organic matter through the Monterey event, Miocene, New Jersey margin (IODP Expedition 313)

    DEFF Research Database (Denmark)

    Fang, Linhao; Bjerrum, Christian J.; Hesselbo, Stephen P.

    2013-01-01

    documented from oceanic settings (i.e., lack of positive excursion of carbon-isotope values in terrestrial organic matter through the Langhian Stage). Factors that may potentially bias local terrestrial carbon-isotope records include reworking from older deposits, degradation and diagenesis, as well....../or reworking of older woody phytoclasts, but where such processes have occurred they do not readily explain the observed carbon-isotope values. It is concluded that the overall carbon-isotope signature for the exchangeable carbon reservoir is distorted, to the extent that the Monterey event excursion...... is not easily identifiable. The most likely explanation is that phytoclast reworking has indeed occurred in clinoform toe-of-slope facies, but the reason for the resulting relatively heavy carbon-isotope values in the Burdigalian remains obscure....

  5. Prey and plastic ingestion of Pacific Northern Fulmars (Fulmarus glacialis rogersii) from Monterey Bay, California.

    Science.gov (United States)

    Donnelly-Greenan, Erica L; Harvey, James T; Nevins, Hannahrose M; Hester, Michelle M; Walker, William A

    2014-08-15

    Marine plastic pollution affects seabirds, including Pacific Northern Fulmars (Fulmarus glacialis rodgersii), that feed at the surface and mistake plastic for prey or incidentally ingest it. Direct and indirect health issues can result, including satiety and possibly leading to inefficient foraging. Our objective was to examine fulmar body condition, identify cephalopod diet to species, enumerate and weigh ingested plastic, and determine if prey number and size were correlated with ingested plastics in beach-cast fulmars wintering in Monterey Bay California (2003, n=178: 2007, n=185). Fulmars consumed mostly Gonatus pyros, G. onyx, and G. californiensis of similar size for both years. We found a significant negative correlation between pectoral muscle index and average size of cephalopod beaks per stomach; a significant increase in plastic categories between 2003 and 2007; and no significant correlation between number and mass of plastic compared with number and size of prey for either year. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. CCN Properties of Organic Aerosol Collected Below and within Marine Stratocumulus Clouds near Monterey, California

    Directory of Open Access Journals (Sweden)

    Akua Asa-Awuku

    2015-10-01

    Full Text Available The composition of aerosol from cloud droplets differs from that below cloud. Its implications for the Cloud Condensation Nuclei (CCN activity are the focus of this study. Water-soluble organic matter from below cloud, and cloud droplet residuals off the coast of Monterey, California were collected; offline chemical composition, CCN activity and surface tension measurements coupled with Köhler Theory Analysis are used to infer the molar volume and surfactant characteristics of organics in both samples. Based on the surface tension depression of the samples, it is unlikely that the aerosol contains strong surfactants. The activation kinetics for all samples examined are consistent with rapid (NH42SO4 calibration aerosol. This is consistent with our current understanding of droplet kinetics for ambient CCN. However, the carbonaceous material in cloud drop residuals is far more hygroscopic than in sub-cloud aerosol, suggestive of the impact of cloud chemistry on the hygroscopic properties of organic matter.

  7. Models, Analysis, and Recommendations Pertaining to the Retention of Naval Special Warfare s Mid-Level Officers

    Science.gov (United States)

    2013-12-01

    The Analytic Hierarch/Network Process,” in Rev. R. Acad. Cien. Serie A. Mat (RACSAM), submitted by Francisco Javier Giron (Real Academia de Ciencias ...Academia de Ciencias : Spain. Scott, Nathan. Naval Special Warfare Officer Retention Survey. Monterey, CA: NPS Press, September 2013. Whittenberger

  8. Currents, temperature, conductivity, pressure, sigma-theta, and attenuation data from moorings deployed in Monterey Bay from platforms WILLIAM A. MCGAW, NOAA Ship McARTHUR, and POINT SUR from 1995-05-16 to 1998-08-17 (NODC Accession 0067571)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Monterey Bay National Marine Sanctuary data were part of a large, multi-disciplinary experiment to characterize the Sanctuary's geologic environment. These data...

  9. Moisture Adsorption and Thermodynamic Properties of California Grown Almonds (Varieties: Nonpareil and Monterey

    Directory of Open Access Journals (Sweden)

    Li Zuo Taitano

    2012-04-01

    Full Text Available Moisture adsorption characteristics of California grown almonds (Nonpareil: pasteurized and unpasteurized almonds; Monterey: pasteurized, unpasteurized and blanched almonds were obtained using the gravimetric method over a range of water activities from 0.11 to 0.98 at 7-50ºC. The weights of almonds were measured until samples reached a constant weight. The relationship between equilibrium moisture content and water activity was established using the Guggenheim-Anderson-de Boer model. The diffusion coefficient of water in almond kernels was calculated based on Ficks second law. The monolayer moisture value of almonds ranged from 0.020 to 0.035 kg H2O kg-1 solids. The diffusion coefficient increased with temperature at a constant water activity, and decreased with water activity at a constant temperature. The thermodynamic properties (net isosteric heat, differential enthalpy and entropy were also determined. The net isosteric heat of adsorption decreased with the increasing moisture content, and the plot of differential enthalpy versus entropy satisfied the enthalpy-entropy compensation theory. The adsorption process of almond samples was enthalpy driven over the range of studied moisture contents.

  10. 5th International Conference on Cryocoolers

    CERN Document Server

    1989-01-01

    The Cryocoolers 5 proceedings archives the contributions of leading international experts at the 5th International Cryocooler Conference that was held in Monterey, California on August 18-19, 1988. The authors submitted twenty six papers describing advancements and applications of cryocoolers in the temperature range below 80K. This year's conference was hosted by the U.S. Naval Postgraduate School in Monterey, California, and the conference proceedings reproduced here were published by the Wright-Patterson AFB in Ohio.

  11. Primary School Teachers' Knowledge, Attitude and Perceived ...

    African Journals Online (AJOL)

    This study endeavored to investigate primary school teachers' knowledge, attitudes, and perceived practices of continuous assessment (CA). Ninety-five primary school teachers from three primary schools in West Gojjam, Ethiopia, were randomly selected for the study. Questionnaire, interviews and content analyses were ...

  12. EnviroAtlas - Fresno, CA - Greenspace Around Schools by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas data set shows the number of schools in each block group in the EnviroAtlas community boundary as well as the number of schools where less than 25%...

  13. 77 FR 18815 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-03-28

    ... NVO License. American Patriot Lines, Inc. dba Tier One Logistics (NVO), 8616 La Tijera Boulevard, 401..., AL 36608. Officer: Samford T. Myers, Manager (Qualifying Individual). Application Type: New NVO & OFF License. Bluesea Logistics Corporation (NVO), 327 Elizabeth Avenue, Apt. A, Monterey Park, CA 91755-2044...

  14. The Analysis, Numerical Simulation, and Diagnosis of Extratropical Weather Systems

    Science.gov (United States)

    2000-09-30

    MRY) and I developed a collaboration with the NRL/SSMIS Lower-Atmospheric Sounding Capability program; Gene Poe (NRL, Team Leader). The effort is...Geophysical Society Annual Meeting (Nice, Fance ; April 2000), the Extratropical Cyclone Workshop (Monterey, CA; Sept. 2000), and in seminars at NCAR

  15. 78 FR 69077 - Army Education Advisory Subcommittee Meeting Notice

    Science.gov (United States)

    2013-11-18

    ... DEPARTMENT OF DEFENSE Department of the Army Army Education Advisory Subcommittee Meeting Notice... leading to provisional findings will be referred to the Army Education Advisory Committee for deliberation...: ATFL-APO, Monterey, CA 93944, [email protected]us.army.mil , (831) 242-5828. SUPPLEMENTARY INFORMATION...

  16. New technological developments provide deep-sea sediment density flow insights: the Monterey Coordinated Canyon Experiment

    Science.gov (United States)

    O'Reilly, T. C.; Kieft, B.; Chaffey, M. R.; Wolfson-Schwehr, M.; Herlien, R.; Bird, L.; Klimov, D.; Paull, C. K.; Gwiazda, R.; Lundsten, E. M.; Anderson, K.; Caress, D. W.; Sumner, E. J.; Simmons, S.; Parsons, D. R.; Talling, P.; Rosenberger, K. J.; Xu, J.; Maier, K. L.; Gales, J. A.

    2017-12-01

    The Monterey Coordinated Canyon Experiment (CCE) deployed an array of instruments along the Monterey Canyon floor to characterize the structure, velocity and frequency of sediment flows. CCE utilized novel technologies developed at MBARI to capture sediment flow data in unprecedented detail. 1. The Seafloor Instrument Node (SIN) at 1850 meters depth housed 3 ADCPs at 3 different frequencies, CTD, current meter, oxygen optode, fluorometer/backscatter sensor, and logged data at 10 second intervals or faster. The SIN included an acoustic modem for communication with shore through a Wave Glider relay, and provided high-resolution measurements of three flow events during three successive deployments over 1.5 years. 2. Beachball-sized Benthic Event Detectors (BEDs) were deployed on or under the seafloor to measure the characteristics of sediment density flows. Each BED recorded data from a pressure sensor and a 3-axis accelerometer and gyro to characterize motions during transport events (e.g. tumble vs rotation). An acoustic modem capable of operating through more than a meter of sediment enabled communications with a ship or autonomous surface vehicle. Multiple BEDs were deployed at various depths in the canyon during CCE, detecting and measuring many transport events; one BED moved 9 km down canyon in 50 minutes during one event. 3. Wave Glider Hot Spot (HS), equipped with acoustic and RF modems, acted as data relay between SIN, BEDs and shore, and acoustically located BEDs after sediment density flows.. In some cases HS relayed BED motion data to shore within a few hours of the event. HS provided an acoustic console to the SIN, allowing shore-based users to check SIN health and status, perform maintenance, etc. 4. Mapping operations were conducted 4 times at the SIN site to quantify depositional and erosional patterns, utilizing a prototype ultra-high-resolution mapping system on the ROV Doc Ricketts. The system consists of a 400-kHz Reson 7125 multibeam sonar, a 3

  17. AN ADVANCED FRACTURE CHARACTERIZATION AND WELL PATH NAVIGATION SYSTEM FOR EFFECTIVE RE-DEVELOPMENT AND ENHANCEMENT OF ULTIMATE RECOVERY FROM THE COMPLEX MONTEREY RESERVOIR OF SOUTH ELLWOOD FIELD, OFFSHORE CALIFORNIA

    Energy Technology Data Exchange (ETDEWEB)

    Steve Horner

    2004-04-29

    Venoco Inc, intends to re-develop the Monterey Formation, a Class III basin reservoir, at South Ellwood Field, Offshore Santa Barbara, California. Well productivity in this field varies significantly. Cumulative Monterey production for individual wells has ranged from 260 STB to 8,700,000 STB. Productivity is primarily affected by how well the well path connects with the local fracture system and the degree of aquifer support. Cumulative oil recovery to date is a small percentage of the original oil in place. To embark upon successful re-development and to optimize reservoir management, Venoco intends to investigate, map and characterize field fracture patterns and the reservoir conduit system. State of the art borehole imaging technologies including FMI, dipole sonic and cross-well seismic, interference tests and production logs will be employed to characterize fractures and micro faults. These data along with the existing database will be used for construction of a novel geologic model of the fracture network. Development of an innovative fracture network reservoir simulator is proposed to monitor and manage the aquifer's role in pressure maintenance and water production. The new fracture simulation model will be used for both planning optimal paths for new wells and improving ultimate recovery. In the second phase of this project, the model will be used for the design of a pilot program for downhole water re-injection into the aquifer simultaneously with oil production. Downhole water separation units attached to electric submersible pumps will be used to minimize surface fluid handling thereby improving recoveries per well and field economics while maintaining aquifer support. In cooperation with the DOE, results of the field studies as well as the new models developed and the fracture database will be shared with other operators. Numerous fields producing from the Monterey and analogous fractured reservoirs both onshore and offshore will benefit from the

  18. Algorithms for Efficient Intelligence Collection

    Science.gov (United States)

    2013-09-01

    2006. Cortical substrates for exploratory decisions in humans. Nature 441(7095) 876–879. Deitchman, S. J. 1962. A lanchester model of guerrilla...Monterey, CA. Pearl, J. 1986. Fusion, propagation and structuring in belief networks. Artificial Intelligence 29 241–288. Schaffer, M. B. 1968. Lanchester

  19. Effects of pruning in Monterey pine plantations affected by Fusarium circinatum

    Energy Technology Data Exchange (ETDEWEB)

    Bezos, D.; Lomba, J. M.; Martinez-Alvarez, P.; Fernandez, M.; Diez, J. J.

    2012-07-01

    Fusarium circinatum Nirenberg and O'Donnell (1998) is the causal agent of Pitch Canker Disease (PCD) in Pinus species, producing damage to the main trunk and lateral branches as well as causing branch dieback. The disease has been detected recently in northern Spain in Pinus spp. seedlings at nurseries and in Pinus radiata D. Don adult trees in plantations. Fusarium circinatum seems to require a wound to enter the tree, not only that as caused by insects but also that resulting from damage by humans, i.e. mechanical wounds. However, the effects of pruning on the infection process have yet to be studied. The aim of the present study was to know how the presence of mechanical damage caused by pruning affects PCD occurrence and severity in P. radiata plantations. Fifty P. radiata plots (pruned and unpruned) distributed throughout 16 sites affected by F. circinatum in the Cantabria region (northern Spain) were studied. Symptoms of PCD presence, such as dieback, oozing cankers and trunk deformation were evaluated in 25 trees per plot and related to pruning effect. A significant relationship between pruning and the number of cankers per tree was observed, concluding that wounds caused by pruning increase the chance of pathogen infection. Other trunk symptoms, such as the presence of resin outside the cankers, were also higher in pruned plots. These results should be taken into account for future management of Monterey Pine plantations. (Author) 36 refs.

  20. Computations for Truck Sliding with TRUCK 3.1 Code

    Science.gov (United States)

    1989-08-01

    16 REFERENCES 1. L u. \\Villiam N.. Hobbs. Norman P. and Atkinson, Michael. TRUCK 3.1-An Improrcd Digital (’oiputtr Program for Calculating the Response...for Operations and Plans ATIN: Technical Libary Director of Chemical & Nuear Operations Dpartnt of the AIW Waskbington, DC 20310 1 Cocaeder US Ay...Lawrenoe Livermore Lab. ATIN: Code 2124, Tedhnical ATTN: Tech Info Dept L-3 Reports Libary P.O. Be 808 Monterey, CA 93940 Livermore, CA 94550 AFSC

  1. A Devil in the Details: Matrix-Dependent 40Ca42Ca++/42Ca+ and Its Effects on Estimates of the Initial 41Ca/40Ca in the Solar System

    Science.gov (United States)

    McKeegan, K. D.; Liu, M.-C.

    2015-07-01

    Ian Hutcheon established that the molecular ion interference 40Ca42Ca++/42Ca+ on 41K+ is strongly dependent on the mineral analyzed. Correction for this "matrix effect" led to a downward revision of the initial 41Ca/40Ca of the solar system.

  2. What Can History Teach Us A Comparative Historical Analysis On the Reserve Officer Training Corps and the Department of Homeland Security

    Science.gov (United States)

    2015-12-01

    services.107 Such academic fields and capabilities as “foreign language proficiency, multicultural curricula, rigorous historical study, specialty...Belvoir, Virginia 2. Dudley Knox Library Naval Postgraduate School Monterey, California

  3. 75 FR 42446 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-07-21

    ... Transportation Intermediary (OTI) pursuant to section 19 of the Shipping Act of 1984 as amended (46 U.S.C... Shipping Limited (NVO), 1000 Corporate Center Drive, Suite 320, Monterey Park, CA 91754. Officers: Joey Tam, President/CEO (Qualifying Individual), Yu C. Lee, Secretary/Treasurer. Application Type: Name Change. Ever...

  4. Hydrolysis of molten CaCl2-CaF2 with additions of CaO

    Directory of Open Access Journals (Sweden)

    Espen Olsen

    2017-10-01

    Full Text Available Calcium halide based molten salts have recently attracted interest for a number of applications such as direct reduction of oxides for metal production and as liquefying agent in cyclic sorption processes for CO2 by CaO from dilute flue gases (Ca-looping. A fundamental aspect of these melts is the possible hydrolysis reaction upon exposure to gaseous H2O forming corrosive and poisonous hydrogen halides. In this work experiments have been performed investigating the formation of HCl and HF from a molten salt consisting of a 13.8 wt% CaF2 in CaCl2 eutectic exposed to a flowing gas consisting of 10 vol% H2O in N2. Hydrolysis has been investigated as function of content of CaO and temperature. HCl and HF are shown to be formed at elevated temperatures; HCl forms to a substantially larger extent than HF. Addition of CaO has a marked, limiting effect on the hydrolysis. Thermodynamic modeling of the reaction indicates activity coefficients for CaO above unity in the system. For cyclic CO2-capture based on thermal swing, it is advisable to keep the temperature in the carbonation (absorption reactor well below 850 ℃ while maintaining a high CaO content if molten CaCl2 is employed. Similar conclusions can be drawn with regards to CaF2.

  5. Cost-effectiveness of a school-based health promotion program in Canada: A life-course modeling approach.

    Science.gov (United States)

    Ekwaru, John Paul; Ohinmaa, Arto; Tran, Bach Xuan; Setayeshgar, Solmaz; Johnson, Jeffrey A; Veugelers, Paul J

    2017-01-01

    The Alberta Project Promoting active Living and healthy Eating in Schools (APPLE Schools) has been recognized as a "best practice" in preventing childhood obesity. To inform decision making on the economic implications of APPLE Schools and to justify investment, we evaluated the project's cost-effectiveness following a life-course approach. We developed a state transition model for the lifetime progression of body weight status comparing elementary school students attending APPLE Schools and control schools. This model quantified the lifetime impact of APPLE Schools in terms of prevention of excess body weight, chronic disease and improved quality-adjusted life years (QALY), from a school system's cost perspective. Both costs and health outcomes were discounted to their present value using 3% discount rate. The incremental cost-effectiveness ratio(ICER) of APPLE schools was CA$33,421 per QALY gained, and CA$1,555, CA$1,709 and CA$14,218 per prevented person years of excess weight, obesity and chronic disease, respectively. These estimates show that APPLE Schools is cost effective at a threshold of ICER Schools was cost effective more than 64% of the time per QALY gained, when using a threshold of ICERSchool-based health promotion, such as APPLE Schools is a cost-effective intervention for obesity prevention and reduction of chronic disease risk over the lifetime. Expanding the coverage and allocating resources towards school-based programs like the APPLE Schools program, is likely to reduce the public health burden of obesity and chronic diseases.

  6. Biomonitoring of marine vertebrates in Monterey Bay using eDNA metabarcoding.

    Directory of Open Access Journals (Sweden)

    Elizabeth A Andruszkiewicz

    Full Text Available Molecular analysis of environmental DNA (eDNA can be used to assess vertebrate biodiversity in aquatic systems, but limited work has applied eDNA technologies to marine waters. Further, there is limited understanding of the spatial distribution of vertebrate eDNA in marine waters. Here, we use an eDNA metabarcoding approach to target and amplify a hypervariable region of the mitochondrial 12S rRNA gene to characterize vertebrate communities at 10 oceanographic stations spanning 45 km within the Monterey Bay National Marine Sanctuary (MBNMS. In this study, we collected three biological replicates of small volume water samples (1 L at 2 depths at each of the 10 stations. We amplified fish mitochondrial DNA using a universal primer set. We obtained 5,644,299 high quality Illumina sequence reads from the environmental samples. The sequence reads were annotated to the lowest taxonomic assignment using a bioinformatics pipeline. The eDNA survey identified, to the lowest taxonomic rank, 7 families, 3 subfamilies, 10 genera, and 72 species of vertebrates at the study sites. These 92 distinct taxa come from 33 unique marine vertebrate families. We observed significantly different vertebrate community composition between sampling depths (0 m and 20/40 m deep across all stations and significantly different communities at stations located on the continental shelf (200 m bottom depth. All but 1 family identified using eDNA metabarcoding is known to occur in MBNMS. The study informs the implementation of eDNA metabarcoding for vertebrate biomonitoring.

  7. Spatial and temporal genetic homogeneity of the Monterey Spanish mackerel, Scomberomorus concolor, in the Gulf of California

    Directory of Open Access Journals (Sweden)

    Erika Magallón-Gayón

    2016-10-01

    Full Text Available The genetic homogeneity of the Monterey Spanish mackerel Scomberomorus concolor population in the Gulf of California was confirmed using nine nuclear microsatellite loci in combination with mitochondrial cytochrome b gene sequences. Samples were collected from the upper and central Gulf areas, representing the two main biogeographical regions of the Gulf. The analyses support the existence of a single panmictic population of S. concolor inhabiting the Gulf of California which in terms of fishery management represents a single genetic stock. Additionally, the contemporary effective population size estimated for the S. concolor population (Ne = 3056.9 was high and similar to another pelagic species. The gene flow seems to be bidirectional between the upper and central Gulf, which coincides with the seasonal movements between both regions related to spawning and feeding activities. A population expansion event was detected, which agrees with a colonization-expansion hypothesis of the S. concolor population in the Gulf.

  8. Value of Combined Detection of Serum CEA, CA72-4, CA19-9, CA15-3 and CA12-5 in the Diagnosis of Gastric Cancer.

    Science.gov (United States)

    Chen, Changguo; Chen, Qiuyuan; Zhao, Qiangyuan; Liu, Min; Guo, Jianwei

    2017-05-01

    To examine whether the combined detection of serum tumor markers (CEA, CA72-4, CA19-9, CA15-3 and CA12-5) improves the sensitivity and accuracy in the diagnosis of gastric cancer (GC). An automatic chemiluminescence immune analyzer with matched kits was used to determine the levels of serum CEA, CA72-4, CA19-9, CA15-3, and CA12-5 in 87 patients with gastric cancer (GC group), 60 patients with gastric benign diseases (GBD group) who were hospitalized during the same period, and 40 healthy subjects undergoing a physical examination. The values of these 5 tumor markers in the diagnosis of gastric cancer were analyzed. The levels of serum CEA, CA72-4, CA19-9, and CA12-5 were higher in the GC group than in the GBD group and healthy subjects, and these differences were significant ( P 0.05). The combined detection of CEA, CA72-4, CA19-9, and CA12-5 had a higher diagnostic value for gastric cancer than did single detection, and the positive detection rate of the combined detection of the four tumor markers was 60.9%. The diagnostic power when using the combined detection of CA72-4, CEA, CA19-9, and CA12-5 was the best. The combined detection of serum CA72-4, CEA, CA19-9 and CA12-5 increases the sensitivity and accuracy in the diagnosis of GC and can thus be considered an important tool for early diagnosis. © 2017 by the Association of Clinical Scientists, Inc.

  9. 16TH Annual Review of Progress in Applied Computational Electromagnetics of the Naval Postgraduate School, Monterey, CA. Volume I

    Science.gov (United States)

    2000-03-24

    Dielectric-Coated Circular Cylinder Using the Reciprocity Theroem " R.A. Martin and D.H. W emer...2.2)2 or (2.2)3 can be dropped. By the logic of [2, 15], we retain the divergence constraint (2.2)3. By rescaling E3 as En’’ = 3Es, we can reduce...F) 1 P or (-VE3, VF3) = w 2(cE3, F3). (3.8) (eE, Vq) = 0, It can be shown then that 83 = 0 is not an eigenvalue of (3.7). Owing to the divergence

  10. Sound Propagation Considerations for a Deep-Ocean Acoustic Network

    Science.gov (United States)

    2009-12-01

    classic “ tea cup” surveillance volume for a bottom sensor. 27 Figure 18. TL of a 100-Hz, 3995-m source using a 4000-m Munk sound speed profile B...18. LTJG Pongaskorn Sommai, Royal Thai Navy Naval Postgraduate School Monterey, California 19. ENS William Jenkins, USN Naval Postgraduate School

  11. Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization.

    Science.gov (United States)

    Kim, Eun Young; Rumpf, Christine H; Van Petegem, Filip; Arant, Ryan J; Findeisen, Felix; Cooley, Elizabeth S; Isacoff, Ehud Y; Minor, Daniel L

    2010-12-01

    Interactions between voltage-gated calcium channels (Ca(V)s) and calmodulin (CaM) modulate Ca(V) function. In this study, we report the structure of a Ca(2+)/CaM Ca(V)1.2 C-terminal tail complex that contains two PreIQ helices bridged by two Ca(2+)/CaMs and two Ca(2+)/CaM-IQ domain complexes. Sedimentation equilibrium experiments establish that the complex has a 2:1 Ca(2+)/CaM:C-terminal tail stoichiometry and does not form higher order assemblies. Moreover, subunit-counting experiments demonstrate that in live cell membranes Ca(V)1.2s are monomers. Thus, contrary to previous proposals, the crystallographic dimer lacks physiological relevance. Isothermal titration calorimetry and biochemical experiments show that the two Ca(2+)/CaMs in the complex have different properties. Ca(2+)/CaM bound to the PreIQ C-region is labile, whereas Ca(2+)/CaM bound to the IQ domain is not. Furthermore, neither of lobes of apo-CaM interacts strongly with the PreIQ domain. Electrophysiological studies indicate that the PreIQ C-region has a role in calcium-dependent facilitation. Together, the data show that two Ca(2+)/CaMs can bind the Ca(V)1.2 tail simultaneously and indicate a functional role for Ca(2+)/CaM at the C-region site.

  12. The site of net absorption of Ca from the intestinal tract of growing pigs and effect of phytic acid, Ca level and Ca source on Ca digestibility.

    Science.gov (United States)

    González-Vega, J Caroline; Walk, Carrie L; Liu, Yanhong; Stein, Hans H

    2014-01-01

    An experiment was conducted to test the hypothesis that the standardised digestibility of Ca in calcium carbonate and Lithothamnium calcareum Ca is not different regardless of the level of dietary Ca, and that phytic acid affects the digestibility of Ca in these two ingredients to the same degree. The objectives were to determine where in the intestinal tract Ca absorption takes place and if there are measurable quantities of basal endogenous Ca fluxes in the stomach, small intestine or large intestine. Diets contained calcium carbonate or L. calcareum Ca as the sole source of Ca, 0% or 1% phytic acid and 0.4% or 0.8% Ca. A Ca-free diet was also formulated and used to measure endogenous fluxes and losses of Ca. Nine growing pigs (initial body weight 23.8 ± 1.3 kg) were cannulated in the duodenum and in the distal ileum, and faecal, ileal and duodenal samples were collected. Duodenal endogenous fluxes of Ca were greater (p calcareum Ca diets, but that was not the case if calcium carbonate was the source of Ca (interaction, p calcareum Ca was greater (p calcareum Ca. In conclusion, under the conditions of this experiment, standardised digestibility of Ca is not affected by the level of phytic acid, but may be affected by dietary Ca level depending on the Ca source. Calcium from calcium carbonate is mostly absorbed before the duodenum, but Ca from L. calcareum Ca is mostly absorbed in the jejunum and ileum.

  13. Acquisition Research: Creating Synergy for Informed Change. Proceedings of the Annual Acquisition Research Symposium (3rd) Held in Monterey, California on 17-18 May 2006

    Science.gov (United States)

    2006-04-30

    Report NPS-GSBPP-04- 008). Monterrey , CA: Naval Postgraduate School. Huxham, C. (1996). Collaboration and collaborative advantage. In C. Huxham (Ed...family courts are referring more and more cases of family disputes ( divorce /child support) to mediation; some local courts require mediation prior...problem with this idea, but divorced of capital asset decisions, keeping PPBE as a budgeting system seems overly bureaucratic. What system the remaining

  14. Fabrication of large-pore mesoporous Ca-Si-based bioceramics for bone regeneration

    Directory of Open Access Journals (Sweden)

    Zeng D

    2017-11-01

    Full Text Available Deliang Zeng,1,2 Xingdi Zhang,3 Xiao Wang,1,2 Lingyan Cao,1 Ao Zheng,1,2 Jiahui Du,1,2 Yongsheng Li,3 Qingfeng Huang,1 Xinquan Jiang1,2 1Department of Prosthodontics, School of Medicine, Ninth People’s Hospital affiliated to Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 2Oral Bioengineering Laboratory, Shanghai Research Institute of Stomatology, School of Medicine, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 3Laboratory of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, People’s Republic of China Abstract: Our previous study revealed that mesoporous Ca-Si-based materials exhibited excellent osteoconduction because dissolved ions could form a layer of hydroxycarbonate apatite on the surface of the materials. However, the biological mechanisms underlying bone regeneration were largely unknown. The main aim of this study was to evaluate the osteogenic ability of large-pore mesoporous Ca-Si-based bioceramics (LPMSCs by alkaline phosphatase assay, real-time PCR analysis, von Kossa, and alizarin red assay. Compared with large-pore mesoporous silica (LPMS, LPMSCs had a better effect on the osteogenic differentiation of dental pulp cells. LPMSC-2 and LPMSC-3 with higher calcium possessed better osteogenic abilities than LPMSC-1, which may be related to the calcium-sensing receptor pathway. Furthermore, the loading capacity for recombinant human platelet-derived growth factor-BB was satisfactory in LPMSCs. In vivo, the areas of new bone formation in the calvarial defect repair were increased in the LPMSC-2 and LPMSC-3 groups compared with the LPMSC-1 and LPMS groups. We concluded that LPMSC-2 and LPMSC-3 possessed both excellent osteogenic abilities and satisfactory loading capacities, which may be

  15. Electrical Resistivity Imaging of Seawater Intrusion into the Monterey Bay Aquifer System.

    Science.gov (United States)

    Pidlisecky, A; Moran, T; Hansen, B; Knight, R

    2016-03-01

    We use electrical resistivity tomography to obtain a 6.8-km electrical resistivity image to a depth of approximately 150 m.b.s.l. along the coast of Monterey Bay. The resulting image is used to determine the subsurface distribution of saltwater- and freshwater-saturated sediments and the geologic controls on fluid distributions in the region. Data acquisition took place over two field seasons in 2011 and 2012. To maximize our ability to image both vertical and horizontal variations in the subsurface, a combination of dipole-dipole, Wenner, Wenner-gamma, and gradient measurements were made, resulting in a large final dataset of approximately 139,000 data points. The resulting resistivity section extends to a depth of 150 m.b.s.l., and is used, in conjunction with the gamma logs from four coastal monitoring wells to identify four dominant lithologic units. From these data, we are able to infer the existence of a contiguous clay layer in the southern portion of our transect, which prevents downward migration of the saltwater observed in the upper 25 m of the subsurface to the underlying freshwater aquifer. The saltwater and brackish water in the northern portion of the transect introduce the potential for seawater intrusion into the hydraulically connected freshwater aquifer to the south, not just from the ocean, but also laterally from north to south. © 2015, National Ground Water Association.

  16. Ca2+/cation antiporters (CaCA: Identification, characterization and expression profiling in bread wheat (Triticum aestivum L.

    Directory of Open Access Journals (Sweden)

    Mehak Taneja

    2016-11-01

    Full Text Available The Ca2+/cation antiporters (CaCA superfamily proteins play vital function in Ca2+ ion homeostasis, which is an important event during development and defense response. Molecular characterization of these proteins has been performed in certain plants, but they are still not characterized in Triticum aestivum (bread wheat. Herein, we identified thirty four TaCaCA superfamily proteins, which were classified into TaCAX, TaCCX, TaNCL and TaMHX protein families based on their structural organization and evolutionary relation with earlier reported proteins. Since the T. aestivum comprises an allohexaploid genome, TaCaCA genes were derived from each A, B and D subgenome and homeologous chromosome (HC, except chromosome-group 1. Majority of genes were derived from more than one HCs in each family that were considered as homeologous genes (HGs due to their high similarity with each other. These HGs showed comparable gene and protein structures in terms of exon/intron organization and domain architecture. Majority of TaCaCA proteins comprised two Na_Ca_ex domains. However, TaNCLs consisted of an additional EF-hand domain with calcium binding motifs. Each TaCaCA protein family consisted of about ten transmembrane and two α-repeat regions with specifically conserved signature motifs except TaNCL, which had single α-repeat. Variable expression of most of the TaCaCA genes during various developmental stages suggested their specified role in development. However, constitutively high expression of a few genes like TaCAX1-A and TaNCL1-B indicated their role throughout the plant growth and development. The modulated expression of certain genes during biotic (fungal infections and abiotic stresses (heat, drought, salt suggested their role in stress response. Majority of TaCCX and TaNCL family genes were found highly affected during various abiotic stresses. However the role of individual gene needs to be established. The present study unfolded the opportunity

  17. Ca2+/Cation Antiporters (CaCA): Identification, Characterization and Expression Profiling in Bread Wheat (Triticum aestivum L.).

    Science.gov (United States)

    Taneja, Mehak; Tyagi, Shivi; Sharma, Shailesh; Upadhyay, Santosh Kumar

    2016-01-01

    The Ca 2+ /cation antiporters (CaCA) superfamily proteins play vital function in Ca 2+ ion homeostasis, which is an important event during development and defense response. Molecular characterization of these proteins has been performed in certain plants, but they are still not characterized in Triticum aestivum (bread wheat). Herein, we identified 34 TaCaCA superfamily proteins, which were classified into TaCAX, TaCCX, TaNCL, and TaMHX protein families based on their structural organization and evolutionary relation with earlier reported proteins. Since the T. aestivum comprises an allohexaploid genome, TaCaCA genes were derived from each A, B, and D subgenome and homeologous chromosome (HC), except chromosome-group 1. Majority of genes were derived from more than one HCs in each family that were considered as homeologous genes (HGs) due to their high similarity with each other. These HGs showed comparable gene and protein structures in terms of exon/intron organization and domain architecture. Majority of TaCaCA proteins comprised two Na_Ca_ex domains. However, TaNCLs consisted of an additional EF-hand domain with calcium binding motifs. Each TaCaCA protein family consisted of about 10 transmembrane and two α-repeat regions with specifically conserved signature motifs except TaNCL, which had single α-repeat. Variable expression of most of the TaCaCA genes during various developmental stages suggested their specified role in development. However, constitutively high expression of a few genes like TaCAX1-A and TaNCL1-B indicated their role throughout the plant growth and development. The modulated expression of certain genes during biotic (fungal infections) and abiotic stresses (heat, drought, salt) suggested their role in stress response. Majority of TaCCX and TaNCL family genes were found highly affected during various abiotic stresses. However, the role of individual gene needs to be established. The present study unfolded the opportunity for detail

  18. Introduction to the LRAPP Environmental-Acoustic Data Bank

    Science.gov (United States)

    1979-06-01

    REFER TO SZC7:3; II OF THE LRAP? ENVIRO.NMENTA..- ACOUSTrC DATA DANK USERS MANUAL. FIGURE 3-4 Examlre of Pace of Text 3-.6 SCALE* . ICD KMfl.At...Commanding Officer 1 Naval Environmental Prediction Research Facility Monterey, CA 93940 Director of Naval Matters 1 Center of Naval Analysis Arlinqton, VA

  19. Business Continuity Management Plan

    Science.gov (United States)

    2014-12-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT BUSINESS CONTINUITY MANAGEMENT PLAN December 2014......maximum 200 words) Navy Supply Systems Command (NAVSUP) lacks a business process framework for the development of Business Continuity Management

  20. Navy Advertising: Targeting Generation Z

    Science.gov (United States)

    2015-12-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT NAVY ADVERTISING : TARGETING GENERATION Z December......study recommends improvements for Navy advertising efficiency by examining characteristics of recruits defined as Generation Z. Data gathered from five

  1. Triggering of frequent turbidity currents in Monterey Canyon and the role of antecedent conditioning

    Science.gov (United States)

    Clare, M. A.; Rosenberger, K. J.; Talling, P.; Barry, J.; Maier, K. L.; Parsons, D. R.; Simmons, S.; Gales, J. A.; Gwiazda, R.; McGann, M.; Paull, C. K.

    2017-12-01

    Turbidity currents pose a hazard to seafloor infrastructure, deliver organic carbon and nutrients to deep-sea communities, and form economically important deposits. Thus, determining the tempo of turbidity current activity and whether different triggers result in different flow modes is important. Identification of specific triggers is challenging, however, because most studies of turbidity currents are based on their deposits. New direct monitoring of flows and environmental conditions provides the necessary temporal constraints to identify triggering mechanisms. The Coordinated Canyon Experiment (CCE) in Monterey Canyon, offshore California is the most ambitious attempt yet to measure turbidity flows and their triggers. The CCE provides precise constraint on flow timing, initiation, and potential triggers based on measurements at 7 different instrumented moorings and 2 metocean buoys. Fifteen turbidity flows were measured in 18 months; with recorded velocities >8 m/s and run-outs of up to 50 km. Presence of live estuarine foraminifera within moored sediment traps suggests that that flows originated in water depths of Turbidity currents are thought to be triggered by processes including earthquakes, river floods and storm waves. Here we analyse seismicity, local river discharge, internal tides, wave height, direction and period data. We identify no clear control of any of these individual variables on flow timing. None of the recorded earthquakes (

  2. Do Multiple Mini-Interview and Traditional Interview Scores Differ in Their Associations With Acceptance Offers Within and Across Five California Medical Schools?

    Science.gov (United States)

    Jerant, Anthony; Henderson, Mark C; Griffin, Erin; Hall, Theodore R; Kelly, Carolyn J; Peterson, Ellena M; Wofsy, David; Franks, Peter

    2018-03-20

    In single-school studies, multiple mini-interview (MMI) and traditional interview (TI) scores are associated with acceptance offers. Unexamined is whether scores at one school are associated with acceptance at other schools; such analyses would mitigate single-school design biases and better estimate how well interviews capture desired applicant attributes. Using data from the five California Longitudinal Evaluation of Admissions Practices (CA-LEAP) public medical schools, the authors examined associations of MMI and TI scores with acceptance offers within and across schools. The analyses included applicants who interviewed at ≥1 CA-LEAP school during the 2011-2013 admissions cycles, when three CA-LEAP schools employed TIs and two employed MMIs. Interview scores were standardized (z-scores: mean = 0, SD = 1) and associations with acceptance offers were examined within and across schools in analyses stratified by school, adjusting for applicant sociodemographics, academic metrics, year, and total number of interviews. Of 4,993 applicants interviewed, 428 (8.6%) interviewed at both MMI schools, 681 (13.6%) at ≥2 TI schools, and 1,327 (26.6%) at ≥1 MMI and ≥1 TI school. For each school, acceptance was associated with interview score at that school and also with interview scores at the other four schools. Cross-school associations of MMI versus TI scores with acceptance did not differ statistically. Interview score at a given CA-LEAP school was associated with acceptance at the other four schools, with no significant differences in associations for MMIs versus TIs. The findings suggest both MMIs and TIs captured attributes valued by admissions teams across CA-LEAP schools.

  3. Control of ciliary motility by Ca2+: Integration of Ca2+-dependent functions and targets for Ca2+ action

    International Nuclear Information System (INIS)

    Evans, T.C.

    1988-01-01

    To identify functions that regulate Ca 2+ -induced ciliary reversal in Paramecium, mutants defective in terminating depolarization-induced backward swimming were selected. Six independent recessive mutations (k-shy) comprising two complementation groups, k-shyA and k-shyB, were identified. All mutants exhibited prolonged backward swimming in depolarizing solutions. Voltage clamp studies revealed that mutant Ca 2+ current amplitudes were reduced, but could be restored to wild type levels by EGTA injection. The recovery of the mutant Ca 2+ current from Ca 2+ -dependent inactivation, and the decay of the Ca 2+ -dependent K + and Ca 2+ -dependent Na + currents after depolarization were slow in k-shy compared to wild type. To identify protein targets of Ca 2+ action, ciliary proteins that interact with calmodulin (CaM) were characterized. With a 125 I-CaM blot assay, several CaM-binding proteins were identified including axonemal, soluble, and membrane-bound polypeptides. Competitive displacement studies with unlabeled Paramecium CaM, bovine CaM, and troponinC suggested that both protein types bind CaM with high affinity and specificity. To examine the presence of CaM-binding sites in intact axonemes, a filtration binding assay was developed

  4. Teaching Business Law to Non-Law Students, Culturally and Linguistically Diverse ("CaLD") Students, and Large Classes

    Science.gov (United States)

    Kariyawasam, Kanchana; Low, Hang Yen

    2014-01-01

    This paper is largely based on the experience of teaching law to students with non-legal background in business schools, with a focus on internationalisation and the large class lecture format. Business schools often consist of large classes which include a significant proportion of Culturally and Linguistically Diverse (CaLD) students. Teaching a…

  5. An inhibitory effect of extracellular Ca2+ on Ca2+-dependent exocytosis.

    Directory of Open Access Journals (Sweden)

    Wei Xiong

    Full Text Available AIM: Neurotransmitter release is elicited by an elevation of intracellular Ca(2+ concentration ([Ca(2+](i. The action potential triggers Ca(2+ influx through Ca(2+ channels which causes local changes of [Ca(2+](i for vesicle release. However, any direct role of extracellular Ca(2+ (besides Ca(2+ influx on Ca(2+-dependent exocytosis remains elusive. Here we set out to investigate this possibility on rat dorsal root ganglion (DRG neurons and chromaffin cells, widely used models for studying vesicle exocytosis. RESULTS: Using photolysis of caged Ca(2+ and caffeine-induced release of stored Ca(2+, we found that extracellular Ca(2+ inhibited exocytosis following moderate [Ca(2+](i rises (2-3 µM. The IC(50 for extracellular Ca(2+ inhibition of exocytosis (ECIE was 1.38 mM and a physiological reduction (∼30% of extracellular Ca(2+ concentration ([Ca(2+](o significantly increased the evoked exocytosis. At the single vesicle level, quantal size and release frequency were also altered by physiological [Ca(2+](o. The calcimimetics Mg(2+, Cd(2+, G418, and neomycin all inhibited exocytosis. The extracellular Ca(2+-sensing receptor (CaSR was not involved because specific drugs and knockdown of CaSR in DRG neurons did not affect ECIE. CONCLUSION/SIGNIFICANCE: As an extension of the classic Ca(2+ hypothesis of synaptic release, physiological levels of extracellular Ca(2+ play dual roles in evoked exocytosis by providing a source of Ca(2+ influx, and by directly regulating quantal size and release probability in neuronal cells.

  6. Special Technology Area Review on Field Programmable Gate Arrays (FPGAs) For Military Applications

    National Research Council Canada - National Science Library

    2005-01-01

    ...) on Field Programmable Gate Arrays (FPGAs) for Military Applications on August 3-4, 2004 at the Naval Postgraduate School in Monterey, California to address issues relevant to the use of this technology in military systems...

  7. Measuring Air Force Contracting Customer Satisfaction

    Science.gov (United States)

    2015-12-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT MEASURING AIR FORCE CONTRACTING CUSTOMER SATISFACTION ...... satisfaction elements should be included in a standardized tool that measures the level of customer satisfaction for AF Contracting’s external and

  8. Reduced endogenous Ca2+ buffering speeds active zone Ca2+ signaling.

    Science.gov (United States)

    Delvendahl, Igor; Jablonski, Lukasz; Baade, Carolin; Matveev, Victor; Neher, Erwin; Hallermann, Stefan

    2015-06-09

    Fast synchronous neurotransmitter release at the presynaptic active zone is triggered by local Ca(2+) signals, which are confined in their spatiotemporal extent by endogenous Ca(2+) buffers. However, it remains elusive how rapid and reliable Ca(2+) signaling can be sustained during repetitive release. Here, we established quantitative two-photon Ca(2+) imaging in cerebellar mossy fiber boutons, which fire at exceptionally high rates. We show that endogenous fixed buffers have a surprisingly low Ca(2+)-binding ratio (∼ 15) and low affinity, whereas mobile buffers have high affinity. Experimentally constrained modeling revealed that the low endogenous buffering promotes fast clearance of Ca(2+) from the active zone during repetitive firing. Measuring Ca(2+) signals at different distances from active zones with ultra-high-resolution confirmed our model predictions. Our results lead to the concept that reduced Ca(2+) buffering enables fast active zone Ca(2+) signaling, suggesting that the strength of endogenous Ca(2+) buffering limits the rate of synchronous synaptic transmission.

  9. Small Business Contracting in the United States and Europe: A Comparative Assessment

    Science.gov (United States)

    2010-03-01

    unlimited. Prepared for: Naval Postgraduate School, Monterey, California 93943 SMALL BUSINESS CONTRACTING IN THE UNITED STATES AND EUROPE: A...COMPARATIVE ASSESSMENT by Max Kidalov, Assistant Professor Procurement Law & Policy March 2010 Graduate School of Business & Public Policy...Daniel T. Oliver Leonard A. Ferrari President Executive Vice President and Provost The report entitled “Small Business Contracting in

  10. Surface Warfare Officers Initial Training For Future Success

    Science.gov (United States)

    2018-03-01

    9 A school is initial rating specific technical training that is given to sailors. 14 Figure 4. Less...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT SURFACE WARFARE OFFICERS— INITIAL TRAINING FOR FUTURE SUCCESS March 2018...professional report 4. TITLE AND SUBTITLE SURFACE WARFARE OFFICERS—INITIAL TRAINING FOR FUTURE SUCCESS 5. FUNDING NUMBERS 6. AUTHOR(S) Arron J

  11. Photoemission study of Ca-intercalated graphite superconductor CaC6

    International Nuclear Information System (INIS)

    Okazaki, Hiroyuki; Yoshida, Rikiya; Iwai, Keisuke; Noami, Kengo; Muro, Takayuki; Nakamura, Tetsuya; Wakita, Takanori; Muraoka, Yuji; Hirai, Masaaki; Tomioka, Fumiaki; Takano, Yoshihiko; Takenaka, Asami; Toyoda, Masahiro; Oguchi, Tamio; Yokoya, Takayoshi

    2010-01-01

    In this work, we have performed resonant photoemission studies of Ca-intercalated graphite superconductor CaC 6 . Using photon energy of the Ca 2p-3d threshold, the photoemission intensity of the peak at Fermi energy (E F ) is resonantly enhanced. This result provides spectroscopic evidence for the existence of Ca 3d states at E F , and strongly supports that Ca 3d state plays a crucial role for the superconductivity of this material with relatively high T c .

  12. Solubility of calcium in CaO-CaCl2

    International Nuclear Information System (INIS)

    Perry, G.S.; Shaw, S.J.

    1991-06-01

    The Direct Oxide Reduction (DOR) process is well established as a process to produce plutonium metal from plutonium dioxide by reaction with calcium. Calcium chloride is added to dissolve the calcium oxide produced, allowing the metal to coalesce into a button. Since calcium metal melts at 840 0 C and DOR can take place successfully below this temperature, it is likely calcium dissolved in calcium chloride reacts with the plutonium dioxide. The solubility of calcium in calcium chloride is reasonably well established but the effect of the CaO formed during the DOR process on the solubility of calcium has not been previously determined. For this reason the solubility of calcium in CaCl 2 -CaO melts at 800 o C has been studied. The solubility decreases from 2.7 mol % in CaCl 2 to 0.4 mol % in 9 mol % CaO-CaCl 2 . (author)

  13. Ground-Water Quality Data in the Monterey Bay and Salinas Valley Basins, California, 2005 - Results from the California GAMA Program

    Science.gov (United States)

    Kulongoski, Justin T.; Belitz, Kenneth

    2007-01-01

    Ground-water quality in the approximately 1,000-square-mile Monterey Bay and Salinas Valley study unit was investigated from July through October 2005 as part of the California Ground-Water Ambient Monitoring and Assessment (GAMA) program. The study was designed to provide a spatially unbiased assessment of raw ground-water quality, as well as a statistically consistent basis for comparing water quality throughout California. Samples were collected from 94 public-supply wells and 3 monitoring wells in Monterey, Santa Cruz, and San Luis Obispo Counties. Ninety-one of the public-supply wells sampled were selected to provide a spatially distributed, randomized monitoring network for statistical representation of the study area. Six wells were sampled to evaluate changes in water chemistry: three wells along a ground-water flow path were sampled to evaluate lateral changes, and three wells at discrete depths from land surface were sampled to evaluate changes in water chemistry with depth from land surface. The ground-water samples were analyzed for volatile organic compounds (VOCs), pesticides, pesticide degradates, nutrients, major and minor ions, trace elements, radioactivity, microbial indicators, and dissolved noble gases (the last in collaboration with Lawrence Livermore National Laboratory). Naturally occurring isotopes (tritium, carbon-14, helium-4, and the isotopic composition of oxygen and hydrogen) also were measured to help identify the source and age of the sampled ground water. In total, 270 constituents and water-quality indicators were investigated for this study. This study did not attempt to evaluate the quality of water delivered to consumers; after withdrawal from the ground, water typically is treated, disinfected, and (or) blended with other waters to maintain water quality. In addition, regulatory thresholds apply to treated water that is served to the consumer, not to raw ground water. In this study, only six constituents, alpha radioactivity, N

  14. Dissolved inorganic carbon, alkalinity, temperature, salinity and other variables collected from discrete sample and profile observations using CTD, bottle and other instruments from the THOMAS WASHINGTON in the Monterey Bay National Marine Sanctuary, North Pacific Ocean and South Pacific Ocean from 1991-05-31 to 1991-07-11 (NODC Accession 0115000)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0115000 includes chemical, discrete sample, physical and profile data collected from THOMAS WASHINGTON in the Monterey Bay National Marine Sanctuary,...

  15. Brand Caliphate And Recruitment Between The Genders

    Science.gov (United States)

    2016-09-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. BRAND CALIPHATE...... Brand Caliphate. This thesis looks at the recruitment of women and asks if Brand Caliphate specifically targets females with its messaging, and if so

  16. Association between serum CA 19-9 and metabolic syndrome: A cross-sectional study.

    Science.gov (United States)

    Du, Rui; Cheng, Di; Lin, Lin; Sun, Jichao; Peng, Kui; Xu, Yu; Xu, Min; Chen, Yuhong; Bi, Yufang; Wang, Weiqing; Lu, Jieli; Ning, Guang

    2017-11-01

    Increasing evidence suggests that serum CA 19-9 is associated with abnormal glucose metabolism. However, data on the association between CA 19-9 and metabolic syndrome is limited. The aim of the present study was to investigate the association between serum CA 19-9 and metabolic syndrome. A cross-sectional study was conducted on 3641 participants aged ≥40 years from the Songnan Community, Baoshan District in Shanghai, China. Logistic regression analysis was used to evaluate the association between serum CA 19-9 and metabolic syndrome. Multivariate logistic regression analysis showed that compared with participants in the first tertile of serum CA 19-9, those in the second and third tertiles had increased odds ratios (OR) for prevalent metabolic syndrome (multivariate adjusted OR 1.46 [95% confidence interval {CI} 1.11-1.92] and 1.51 [95% CI 1.14-1.98]; P trend  = 0.005). In addition, participants with elevated serum CA 19-9 (≥37 U/mL) had an increased risk of prevalent metabolic syndrome compared with those with serum CA 19-9 metabolic syndrome. In order to confirm this association and identify potential mechanisms, prospective cohort and mechanic studies should be performed. © 2017 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.

  17. Battle of Narratives

    Science.gov (United States)

    2012-06-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited BATTLE OF NARRATIVES...from the NAVAL POSTGRADUATE SCHOOL June 2012 Author: Lars Ruth Approved by: Prof. Sean F. Everton Thesis Advisor Dr. Hy...are more important than are others. For example, for some, social security and taxes are very important while gun control and LGBT are not. For

  18. Hunting The Ghost Gun: An Analysis Of The U.S. Army Infantry Rifle

    Science.gov (United States)

    2016-03-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA JOINT APPLIED PROJECT HUNTING THE GHOST GUN : AN ANALYSIS OF THE U.S. ARMY......LEFT BLANK iii Approved for public release; distribution is unlimited HUNTING THE GHOST GUN : AN ANALYSIS OF THE U.S. ARMY INFANTRY

  19. China’s Influence on U.S.-Latin American Relations

    Science.gov (United States)

    2017-03-01

    citizens lost by the U.S., public perception decidedly declined for the U.S. during this period. While alone not disconcerting, U.S. political influence ...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. CHINA’S INFLUENCE ...

  20. USE OF CUTTING-EDGE HORIZONTAL AND UNDERBALANCED DRILLING TECHNOLOGIES AND SUBSURFACE SEISMIC TECHNIQUES TO EXPLORE, DRILL AND PRODUCE RESERVOIRED OIL AND GAS FROM THE FRACTURED MONTEREY BELOW 10,000 FT IN THE SANTA MARIA BASIN OF CALIFORNIA

    Energy Technology Data Exchange (ETDEWEB)

    George Witter; Robert Knoll; William Rehm; Thomas Williams

    2005-02-01

    This project was undertaken to demonstrate that oil and gas can be drilled and produced safely and economically from a fractured Monterey reservoir in the Santa Maria Basin of California by employing horizontal wellbores and underbalanced drilling technologies. Two vertical wells were previously drilled in this area by Temblor Petroleum with heavy mud and conventional completions; neither was commercially productive. A new well was drilled by the project team in 2004 with the objective of accessing an extended length of oil-bearing, high-resistivity Monterey shale via a horizontal wellbore, while implementing managed-pressure drilling (MPD) techniques to avoid formation damage. Initial project meetings were conducted in October 2003. The team confirmed that the demonstration well would be completed open-hole to minimize productivity impairment. Following an overview of the geologic setting and local field experience, critical aspects of the application were identified. At the pre-spud meeting in January 2004, the final well design was confirmed and the well programming/service company requirements assigned. Various design elements were reduced in scope due to significant budgetary constraints. Major alterations to the original plan included: (1) a VSP seismic survey was delayed to a later phase; (2) a new (larger) surface hole would be drilled rather than re-enter an existing well; (3) a 7-in. liner would be placed into the top of the Monterey target as quickly as possible to avoid problems with hole stability; (4) evaluation activities were reduced in scope; (5) geosteering observations for fracture access would be deduced from penetration rate, cuttings description and hydrocarbon in-flow; and (6) rather than use nitrogen, a novel air-injection MPD system was to be implemented. Drilling operations, delayed from the original schedule by capital constraints and lack of rig availability, were conducted from September 12 to November 11, 2004. The vertical and upper

  1. Use of Cutting-Edge Horizontal and Underbalanced Drilling Technologies and Subsurface Seismic Techniques to Explore, Drill and Produce Reservoired Oil and Gas from the Fractured Monterey Below 10,000 ft in the Santa Maria Basin of California

    Energy Technology Data Exchange (ETDEWEB)

    George Witter; Robert Knoll; William Rehm; Thomas Williams

    2005-09-29

    This project was undertaken to demonstrate that oil and gas can be drilled and produced safely and economically from a fractured Monterey reservoir in the Santa Maria Basin of California by employing horizontal wellbores and underbalanced drilling technologies. Two vertical wells were previously drilled in this area with heavy mud and conventional completions; neither was commercially productive. A new well was drilled by the project team in 2004 with the objective of accessing an extended length of oil-bearing, high-resistivity Monterey shale via a horizontal wellbore, while implementing managed-pressure drilling (MPD) techniques to avoid formation damage. Initial project meetings were conducted in October 2003. The team confirmed that the demonstration well would be completed open-hole to minimize productivity impairment. Following an overview of the geologic setting and local field experience, critical aspects of the application were identified. At the pre-spud meeting in January 2004, the final well design was confirmed and the well programming/service company requirements assigned. Various design elements were reduced in scope due to significant budgetary constraints. Major alterations to the original plan included: (1) a VSP seismic survey was delayed to a later phase; (2) a new (larger) surface hole would be drilled rather than re-enter an existing well; (3) a 7-in. liner would be placed into the top of the Monterey target as quickly as possible to avoid problems with hole stability; (4) evaluation activities were reduced in scope; (5) geosteering observations for fracture access would be deduced from penetration rate, cuttings description and hydrocarbon in-flow; and (6) rather than use nitrogen, a novel air-injection MPD system was to be implemented. Drilling operations, delayed from the original schedule by capital constraints and lack of rig availability, were conducted from September 12 to November 11, 2004. The vertical and upper curved sections were

  2. Elucidating the Role of CaMKK in Cell Cycle and Cell Fate using a C. elegans model

    Science.gov (United States)

    2000-07-01

    domain) or the Aspergillus homologue, anCaMKB (48% overall)(Figure 2). To functionally compare the C. elegans proteins with their mammalian homologues...subunit on the yeast proteome . EMBO J 18, 4157-68 (1999). 14 19. H. Tokumitsu et aL, Substrate recognition by Ca2+/Calmodulin-dependent protein kinase...2 Nicholas School of the Environment Duke University, Durham, NC 27710 Ethan@Duke.Edu In a variety of models, from Xenopus oocytes to Aspergillus to

  3. Underwater Gliders by Dr. Kevin Smith [video

    OpenAIRE

    Naval Postgraduate School Physics

    2015-01-01

    NPS Physics NPS Physics Research Projects Underwater glider research is currently underway in the physics department at the naval postgraduate in Monterey Ca. Dr. Kevin Smith is a specialist in underwater acoustics and sonar systems. He and his team are currently focused on autonomous underwater gliders and developing systems capable of detecting parameters in the ocean and listening for various sources of sound.

  4. Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak

    Science.gov (United States)

    Sankaranarayanan, Rajiv; Li, Yatong; Greensmith, David J.; Eisner, David A.

    2016-01-01

    Key points Ca leak from the sarcoplasmic reticulum through the ryanodine receptor (RyR) reduces the amplitude of the Ca transient and slows its rate of decay.In the presence of β‐adrenergic stimulation, RyR‐mediated Ca leak produces a biphasic decay of the Ca transient with a fast early phase and a slow late phase.Two forms of Ca leak have been studied, Ca‐sensitising (induced by caffeine) and non‐sensitising (induced by ryanodine) and both induce biphasic decay of the Ca transient.Only Ca‐sensitising leak can be reversed by traditional RyR inhibitors such as tetracaine.Ca leak can also induce Ca waves. At low levels of leak, waves occur. As leak is increased, first biphasic decay and then slowed monophasic decay is seen. The level of leak has major effects on the shape of the Ca transient. Abstract In heart failure, a reduction in Ca transient amplitude and contractile dysfunction can by caused by Ca leak through the sarcoplasmic reticulum (SR) Ca channel (ryanodine receptor, RyR) and/or decreased activity of the SR Ca ATPase (SERCA). We have characterised the effects of two forms of Ca leak (Ca‐sensitising and non‐sensitising) on calcium cycling and compared with those of SERCA inhibition. We measured [Ca2+]i with fluo‐3 in voltage‐clamped rat ventricular myocytes. Increasing SR leak with either caffeine (to sensitise the RyR to Ca activation) or ryanodine (non‐sensitising) had similar effects to SERCA inhibition: decreased systolic [Ca2+]i, increased diastolic [Ca2+]i and slowed decay. However, in the presence of isoproterenol, leak produced a biphasic decay of the Ca transient in the majority of cells while SERCA inhibition produced monophasic decay. Tetracaine reversed the effects of caffeine but not of ryanodine. When caffeine (1 mmol l−1) was added to a cell which displayed Ca waves, the wave frequency initially increased before waves disappeared and biphasic decay developed. Eventually (at higher caffeine concentrations), the

  5. crdi.ca

    International Development Research Centre (IDRC) Digital Library (Canada)

    et des enfants d'Afrique. INITIATIVE CONCERTÉE. Innovation pour la santé des mères et des enfants d'Afrique. Centre de recherches pour le développement international. CP Box 8500 Ottawa ON Canada K1G 3H9. Téléphone : +1 613 236 6163 • Télécopieur : +1 613 657 7749 ismea@crdi.ca | www.crdi.ca/ismea crdi.ca.

  6. Technology Security Policy: From the Cold War to the New World Order

    Science.gov (United States)

    1993-12-01

    of Counterproliferation Initiative Legislation. The House DoD Authorization bill essentially rubber -stamps the Administration’s budget request for...Sciences Naval Postgraduate School Monterey, California 93943-5103 5. Richard Ellings I NBR 715 SAFECO Plaza Seattle, Washington 98185 6. LT Dolores M

  7. An Investigation of Bank-to-Turn Missiles.

    Science.gov (United States)

    1986-06-01

    Aerodynamic Model and Analysis The aerodynamic transfer functions of the uncoupled yaw channel autopilot are according to Karadimas , C. thesis [Ref. 41: a...Thesis, Naval Postgraduate School, Monterey California, December 1985 3. Ogata, K., Modern Control Engineering, Prentice-Hall Inc., 1970. 4. Karadimas

  8. Characterization of Bacillus subtilis YfkE (ChaA): a calcium-specific Ca2+/H+ antiporter of the CaCA family.

    Science.gov (United States)

    Fujisawa, Makoto; Wada, Yuko; Tsuchiya, Takahiro; Ito, Masahiro

    2009-08-01

    YfkE, a protein from Bacillus subtilis, exhibits homology to the Ca(2+):Cation Antiporter (CaCA) Family. In a fluorescence-based assay of everted membrane vesicles prepared from Na(+)(Ca(2+))/H(+) antiporter-defective mutant Escherichia coli KNabc, YfkE exhibited robust Ca(2+)/H(+) antiport activity, with a K (m) for Ca(2+) estimated at 12.5 muM at pH 8.5 and 113 muM at pH 7.5. Neither Na(+) nor K(+) served as a substrate. Mg(2+) also did not serve as a substrate, but inhibited the Ca(2+)/H(+) antiporter activity. The Ca(2+) transport capability of YfkE was also observed directly by transport assays in everted membrane vesicles using radiolabeled (45)Ca(2+). Transcriptional analysis from the putative yfkED operon using beta-garactosidase activity as a reporter revealed that both of the yfkE and yfkD genes are regulated by forespore-specific sigma factor, SigG, and the general stress response regulator, SigB. These results suggest that YfkE may be needed for Ca(2+) signaling in the sporulation or germination process in B. subtilis. ChaA is proposed as the designation for YfkE of B. subtilis.

  9. Comparative study of anisotropic superconductivity in CaAlSi and CaGaSi

    International Nuclear Information System (INIS)

    Tamegai, T.; Uozato, K.; Kasahara, S.; Nakagawa, T.; Tokunaga, M.

    2005-01-01

    In order to get some insight into the origin of the anomalous angular dependence of H c2 in a layered intermetallic compound CaAlSi, electronic, superconducting, and structural properties are compared between CaAlSi and CaGaSi. The angular dependence of H c2 in CaGaSi is well described by the anisotropic GL model. Parallel to this finding, the pronounced lattice modulation accompanying the superstructure along the c-axis in CaAlSi is absent in CaGaSi. A relatively large specific heat jump at the superconducting transition in CaAlSi compared with CaGaSi indicates the presence of strong electron-phonon coupling in CaAlSi, which may cause the superstructure and the anomalous angular dependence of H c2

  10. Mass yield distributions for the reactions Ca+Ca, Nb+Nb and Ca+Ca at E/A=800 MeV in the molecular-dynamical model

    International Nuclear Information System (INIS)

    Kiselev, S.M.

    1987-01-01

    Mass yield distributions obtained on the basis of the molecular-dynamical model are presented for the Ca+Ca, Nb+Nb reactions at E/A=400 MeV and Ca+Ca reaction at E/A=800 MeV. For the fragments with masses upto quarter of the mass of initial nucleus the model predicts a power law for mass spectra with almost the same value of the exponent. Such the behaviour is roughly a result of the superposition of the fireball breakup and the disintegration of spectator regions rather than the evidence of a liquid-gas-like phase transition in hot nuclear matter

  11. Assessment methods as effective tools for learning outcomes of students in senior secondary schools in Ila-Orangun, south western Nigeria

    Directory of Open Access Journals (Sweden)

    Lamidi W.A

    2013-06-01

    Full Text Available Different methods of assessment on the students learning outcomes in Agricultural Science at five different secondary schools in Ila-Orangun, Osun State were studied. An arm of a class was used for each test; Continuous Assessment (CA and Conventional Method (CM were used for each arm. Students were taught during their normal school times for the maximum time of forty minutes thrice a week. There were ten objective questions weekly for each assessment of the students in the CA method for six weeks. The same questions were used throughout for all the schools, done simultaneously for CA. Also, sixty questions at once at the end of the sixth week for CM. Standard deviation and regression equations for the mean values were used in the analysis. The results show that CA could be adjudged to be better off than the CM because of its higher mean values in all the schools than the CM. The higher R2 values of 0.99 and 0.88 revealed stronger correlation between different methods of assessment and the targeted learners. The CA test should be used instead of CM; the CM does not make learners to gain much cognitive knowledge when compare with what CA does to students.

  12. Sediment concentrations, flow conditions, and downstream evolution of two turbidity currents, Monterey Canyon, USA

    Science.gov (United States)

    Xu, Jingping; Octavio E. Sequeiros,; Noble, Marlene A.

    2014-01-01

    The capacity of turbidity currents to carry sand and coarser sediment from shallow to deep regions in the submarine environment has attracted the attention of researchers from different disciplines. Yet not only are field measurements of oceanic turbidity currents a rare achievement, but also the data that have been collected consist mostly of velocity records with very limited or no suspended sediment concentration or grain size distribution data. This work focuses on two turbidity currents measured in Monterey Canyon in 2002 with emphasis on suspended sediment from unique samples collected within the body of these currents. It is shown that concentration and grain size of the suspended material, primarily controlled by the source of the gravity flows and their interaction with bed material, play a significant role in shaping the characteristics of the turbidity currents as they travel down the canyon. Before the flows reach their normal or quasi-steady state, which is defined by bed slope, bed roughness, and suspended grain size, they might pass through a preliminary adjustment stage where they are subject to capacity-driven deposition, and release heavy material in excess. Flows composed of fine (silt/clay) sediments tend to be thicker than those with sands. The measured velocity and concentration data confirm that flow patterns differ between the front and body of turbidity currents and that, even after reaching normal state, the flow regime can be radically disrupted by abrupt changes in canyon morphology.

  13. Ventral tegmental area disruption selectively affects CA1/CA2 but not CA3 place fields during a differential reward working memory task.

    Science.gov (United States)

    Martig, Adria K; Mizumori, Sheri J Y

    2011-02-01

    Hippocampus (HPC) receives dopaminergic (DA) projections from the ventral tegmental area (VTA) and substantia nigra. These inputs appear to provide a modulatory signal that influences HPC dependent behaviors and place fields. We examined how efferent projections from VTA to HPC influence spatial working memory and place fields when the reward context changes. CA1 and CA3 process environmental context changes differently and VTA preferentially innervates CA1. Given these anatomical data and electrophysiological evidence that implicate DA in reward processing, we predicted that CA1 place fields would respond more strongly to both VTA disruption and changes in the reward context than CA3 place fields. Rats (N = 9) were implanted with infusion cannula targeting VTA and recording tetrodes aimed at HPC. Then they were tested on a differential reward, win-shift working memory task. One recording session consisted of 5 baseline and 5 manipulation trials during which place cells in CA1/CA2 (N = 167) and CA3 (N = 94) were recorded. Prior to manipulation trials rats were infused with either baclofen or saline and then subjected to control or reward conditions during which the learned locations of large and small reward quantities were reversed. VTA disruption resulted in an increase in errors, and in CA1/CA2 place field reorganization. There were no changes in any measures of CA3 place field stability during VTA disruption. Reward manipulations did not affect performance or place field stability in CA1/CA2 or CA3; however, changes in the reward locations "rescued" performance and place field stability in CA1/CA2 when VTA activity was compromised, perhaps by trigging compensatory mechanisms. These data support the hypothesis that VTA contributes to spatial working memory performance perhaps by maintaining place field stability selectively in CA1/CA2. Copyright © 2009 Wiley-Liss, Inc.

  14. Extremely Elevated CA 125 and CA 19-9 in Endometrioma; A Case Series

    Directory of Open Access Journals (Sweden)

    Vugar Bayramov

    2010-03-01

    Full Text Available Although endometriosis is a benign condition, increased levels of the tumor markers CA 125 and CA 19-9 may be seen. However, these tumor markers reach to very high levels, rarely. In this report, 4 patients between 20 and 43 year-old with extremely elevated CA 125, CA 19-9 and CA 15-3 levels are discussed. In endometriosis extremely increased tumor markers are determined in the case of ruptured endometrioma cyst. There are two mechanisms to clarify extremely elevated levels of CA 125 in endometriosis. First, the peritoneal irritation of CA 125 molecule after the rupture of endometioma cyst and CA 125 secretion from the periton. And the second is penetration of the CA 125 moecule easily to the circulation through the peritoneal endothelial surface after the cyst rupture. In conclusion, the diagnosis of ruptured endometrioma cyst should be kept in mind especially in young patients with extremely elevated serum CA 125 levels with regard to the history and ultrasonographical signs and invasive procedures should be avoided.

  15. Observed Statistics of Extreme Waves

    Science.gov (United States)

    2006-12-01

    hardware used, the reader is referred to Tinder (2000) and Ardhuin et al., (2003). SHOWEX took place during a particularly active hurricane season...c10, 5925-5938. Tinder , C. V., (2000). Swell Transformation Across the Continental Shelf. Master’s Thesis, Naval Postgraduate School, Monterey

  16. Ca isotopes in refractory inclusions

    International Nuclear Information System (INIS)

    Niederer, F.R.; Papanastassiou, D.A.

    1984-01-01

    We report measurements of the absolute isotope abundance of Ca in Ca-Al-rich inclusions from the Allende and Leoville meteorites. Improved high precision measurements are reported also for 46 Ca. We find that nonlinear isotope effects in Ca are extremely rare in these inclusions. The absence of nonlinear effects in Ca, except for the effects in FUN inclusions, is in sharp contrast to the endemic effects in Ti. One fine-grained inclusion shows an excess of 46 Ca of (7 +- 1) per mille, which is consistent with addition of only 46 Ca or of an exotic (*) component with 46 Ca* approx. 48 Ca*. FUN inclusion EK-1-4-1 shows a small 46 Ca excess of (3.3 +- 1.0) per mille; this confirms that the exotic Ca components in EK-1-4-1 were even more deficient in 46 Ca relative to 48 Ca than is the case for normal Ca. The Ca in the Ca-Al-rich inclusions shows mass dependent isotope fractionation effects which have a range from -3.8 to +6.7 per mille per mass unit difference. This range is a factor of 20 wider than the range previously established for bulk meteorites and for terrestrial and lunar samples. Ca and Mg isotope fractionation effects in the Ca-Al-rich inclusions are common and attributed to kinetic isotope effects. (author)

  17. Evolution and Submarine Landslide Potential of Monterey Canyon Head, Offshore Central California

    Science.gov (United States)

    Maier, K. L.; Johnson, S. Y.; Hart, P. E.; Hartwell, S. R.

    2016-12-01

    Monterey Canyon, offshore central California, incises the shelf from near the shoreline to 30 km seaward where axial water depths approach 2,000 m. It is one of the world's most studied submarine canyons, yet debate continues concerning its age, formation, and associated geologic hazards. To address these issues, the USGS, with partial support from the California Seafloor Mapping Program, collected hundreds of kilometers of high-resolution, mini-sparker, single-channel (2009 and 2011 surveys) and multichannel (2015 survey) seismic-reflection profiles near the canyon head. The seismic data were combined with multibeam bathymetry to generate a geologic map of the proximal canyon, which delineates numerous faults and compound submarine landslide headwall scarps (covering up to 4 km2) along canyon walls. Seismic-reflection data reveal a massive ( 100 km2 lateral extent) paleochannel cut-and-fill complex underlying the proximal canyon. These subsurface cut-and-fill deposits span both sides of the relatively narrow modern canyon head, crop out in canyon walls, and incise into Purisima Formation (late Miocene and Pliocene) bedrock to depths of up to 0.3 s two-way travel time ( 240 m) below the modern shelf. We propose that the paleochannel complex represents previous locations of a migrating canyon head, and attribute its origin to multiple alternating cycles of fluvial and submarine canyon erosion and deposition linked to fluctuating sea levels. Thus, the canyon head imaged in modern bathymetry is a relatively young feature, perhaps forming in the last 20,000 years of sea-level rise. The paleocanyon deposits are significantly less consolidated than bedrock in deeper canyon walls, and therefore, are probably more prone to submarine landsliding. Nearby mapped faults occur within the active, distributed, San Andreas fault system, and earthquake-generated strong ground motions are likely triggers for past and future submarine landslides and potential associated tsunamis.

  18. Clinical evaluation of CEA, CA19-9, CA72-4 and CA125 in gastric cancer patients with neoadjuvant chemotherapy.

    Science.gov (United States)

    Sun, Zhipeng; Zhang, Nengwei

    2014-12-29

    In the clinical practice of neoadjuvant chemotherapy, response markers are very important. We aimed o investigate whether tumor markers CEA(carcino-embryonic antigen), CA19-9(carbohydrate antigen 19-9), CA72-4(carbohydrate antigen 72-4), and CA125(carbohydrate antigen 125) can be used to evaluate the response to neoadjuvant chemotherapy, and to evaluate the diagnosis and prognosis value of four tumor markers in the patients of gastric cancer. A retrospective review was performed of 184 gastric cancer patients who underwent a 5-Fu, leucovorin, and oxaliplatin (FOLFOX) neoadjuvant chemotherapy regimen, followed by surgical treatment. Blood samples for CEA, CA19-9, CA72-4, and CA125 levels were taken from patients upon admission to the hospital and after neoadjuvant chemotherapy. Statistical analysis was performed to identify the clinical value of these tumor markers in predicting the survival and the response to neoadjuvant chemotherapy. Median overall survival times of pretreatment CA19-9-positive and CA72-4-positive patients (14.0 +/-2.8 months and 14.8 +/-4.0 months, respectively) were significantly less than negative patients (32.5 +/-8.9 months and 34.0 +/-10.1 months, respectively) (P = 0.000 and P = 0.002, respectively). Pretreatment status of CA19-9 and CA72-4 were independent prognostic factors in gastric cancer patients (P = 0.029 and P = 0.008, respectively). Pretreatment CEA >50 ng/ml had a positive prediction value for clinical disease progression after neoadjuvant chemotherapy according to the ROC curve (AUC: 0.694, 95% CI: 0.517 to 0.871, P = 0.017). The decrease of tumor markers CEA, CA72-4, and CA125 was significant after neoadjuvant chemotherapy (P = 0.030, P = 0.010, and P = 0.009, respectively), especially in patients with disease control (including complete, partial clinical response, and stable disease) (P = 0.012, P = 0.020, and P = 0.025, respectively). A decrease in CA72-4 by more than 70% had

  19. Evaluation of terrestrial photogrammetric point clouds derived from thermal imagery

    Science.gov (United States)

    Metcalf, Jeremy P.; Olsen, Richard C.

    2016-05-01

    Computer vision and photogrammetric techniques have been widely applied to digital imagery producing high density 3D point clouds. Using thermal imagery as input, the same techniques can be applied to infrared data to produce point clouds in 3D space, providing surface temperature information. The work presented here is an evaluation of the accuracy of 3D reconstruction of point clouds produced using thermal imagery. An urban scene was imaged over an area at the Naval Postgraduate School, Monterey, CA, viewing from above as with an airborne system. Terrestrial thermal and RGB imagery were collected from a rooftop overlooking the site using a FLIR SC8200 MWIR camera and a Canon T1i DSLR. In order to spatially align each dataset, ground control points were placed throughout the study area using Trimble R10 GNSS receivers operating in RTK mode. Each image dataset is processed to produce a dense point cloud for 3D evaluation.

  20. Evaluation of Serum CEA, CA19-9, CA72-4, CA125 and Ferritin as Diagnostic Markers and Factors of Clinical Parameters for Colorectal Cancer.

    Science.gov (United States)

    Gao, Yanfeng; Wang, Jinping; Zhou, Yue; Sheng, Sen; Qian, Steven Y; Huo, Xiongwei

    2018-02-09

    Blood-based protein biomarkers have recently shown as simpler diagnostic modalities for colorectal cancer, while their association with clinical pathological characteristics is largely unknown. In this study, we not only examined the sensitivity and reliability of single/multiple serum markers for diagnosis, but also assessed their connection with pathological parameters from a total of 279 colorectal cancer patients. Our study shown that glycoprotein carcinoembryonic antigen (CEA) owns the highest sensitivity among single marker in the order of CEA > cancer antigen 72-4 (CA72-4) > cancer antigen 19-9 9 (CA19-9) > ferritin > cancer antigen 125 (CA125), while the most sensitive combined-markers for two to five were: CEA + CA72-4; CEA + CA72-4 + CA125; CEA + CA19-9 + CA72-4 + CA125; and CEA + CA19-9 + CA72-4 + CA125 + ferritin, respectively. We also demonstrated that patients who had positive preoperative serum CEA, CA19-9, or CA72-4 were more likely with lymph node invasion, positive CA125 were prone to have vascular invasion, and positive CEA or CA125 were correlated with perineural invasion. In addition, positive CA19-9, CA72-4, or CA125 was associated with poorly differentiated tumor, while CEA, CA19-9, CA72-4, CA125 levels were positively correlated with pathological tumor-node-metastasis stages. We here conclude that combined serum markers can be used to not only diagnose colorectal cancer, but also appraise the tumor status for guiding treatment, evaluation of curative effect, and prognosis of patients.

  1. The timing of sediment transport down Monterey Submarine Canyon, offshore California

    Science.gov (United States)

    Stevens, Thomas; Paull, Charles K.; Ussler, William III; McGann, Mary; Buylaert, Jan-Pieter; Lundsten, Eve M.

    2013-01-01

    While submarine canyons are the major conduits through which sediments are transported from the continents out into the deep sea, the time it takes for sediment to pass down through a submarine canyon system is poorly constrained. Here we report on the first study to couple optically stimulated luminescence (OSL) ages of quartz sand deposits and accelerator mass spectrometry 14C ages measured on benthic foraminifera to examine the timing of sediment transport through the axial channel of Monterey Submarine Canyon and Fan, offshore California. The OSL ages date the timing of sediment entry into the canyon head while the 14C ages of benthic foraminifera record the deposition of hemipelagic sediments that bound the sand horizons. We use both single-grain and small (∼2 mm area) single-aliquot regeneration approaches on vibracore samples from fining-upward sequences at various water depths to demonstrate relatively rapid, decadal-scale sand transport to at least 1.1 km depth and more variable decadal- to millennial-scale transport to a least 3.5 km depth on the fan. Significant differences between the time sand was last exposed at the canyon head (OSL age) and the timing of deposition of the sand (from 14C ages of benthic foraminifera in bracketing hemipelagic sediments) are interpreted as indicating that the sand does not pass through the entire canyon instantly in large individual events, but rather moves multiple times before emerging onto the fan. The increased spread in single-grain OSL dates with water depth provides evidence of mixing and temporary storage of sediment as it moves through the canyon system. The ages also indicate that the frequency of sediment transport events decreases with distance down the canyon channel system. The amalgamated sands near the canyon head yield OSL ages that are consistent with a sub-decadal recurrence frequency while the fining-upward sand sequences on the fan indicate that the channel is still experiencing events with a 150

  2. Ca(2+-dependent regulation of the Ca(2+ concentration in the myometrium mitochondria. II. Ca(2+ effects on mitochondria membranes polarization and [Ca(2+](m

    Directory of Open Access Journals (Sweden)

    L. G. Babich

    2017-06-01

    Full Text Available It is known that Ca2+ accumulation in the mitochondria undergoes complex regulation by Ca2+ itself. But the mechanisms of such regulation are still discussed. In this paper we have shown that Ca ions directly or indirectly regulate the level of myometrium mitochondria membranes polarization. The additions of 100 µM Ca2+ were accompanied by depolarization of the mitochondria membranes. The following experiments were designed to study the impact of Ca2+ on the myometrium mitochondria [Ca2+]m. Isolated myometrium mitochondria were preincubated without or with 10 μM Са2+ followed by 100 μM Са2+ addition. Experiments were conducted in three mediums: without ATP and Mg2+ (0-medium, in the presence of 3 mM Mg2+ (Mg-medium and 3 mM Mg2+ + 3 mM ATP (Mg,ATP-medium. It was shown that the effects of 10 μM Са2+ addition were different in different mediums, namely in 0- and Mg-medium the [Ca2+]m values increased, whereas in Mg,ATP-medium statistically reliable changes were not registered. Preincubation of mitochondria with 10 μM Са2+ did not affect the [Ca2+]m value after the addition of 100 μM Са2+. The [Ca2+]m values after 100 μM Са2+ addition were the same in 0- and Mg,ATP-mediums and somewhat lower in Mg-medium. Preliminary incubation of mitochondria with 10 μM Са2+ in 0- and Mg-mediums reduced changes of Fluo 4 normalized fluorescence values that were induced by 100 μM Са2+ additions, but in Mg,ATP-medium such differences were not recorded. It is concluded that Са2+ exchange in myometrium mitochondria is regulated by the concentration of Ca ions as in the external medium, so in the matrix of mitochondria. The medium composition had a significant impact on the [Са2+]m values in the absence of exogenous cation. It is suggested that light increase of [Са2+]m before the addition of 100 μM Са2+ may have a positive effect on the functional activity of the mitochondria.

  3. Study of 40Ca-40Ca elastic scattering at intermediate energy

    International Nuclear Information System (INIS)

    Kumar, Ashok; Srivastava, B.B.

    1980-01-01

    The differential cross sections for 40 Ca- 40 Ca elastic scattering have been calculated at laboratory incident energy of 240 MeV using a sharp cut off of the partial waves below a critical angular momentum, 1sub(c)' to account for absorption. The effective 40 Ca- 40 Ca potential is taken to be the sum of a real nuclear potential and the Coulomb potential. The calculated differential cross sections which are in fair agreement with the experimental data are presented and discussed. (author)

  4. Sustainable Seas Student Intertidal Monitoring Project, Duxbury Reef, Bolinas, CA

    Science.gov (United States)

    Soave, K.; Dean, A.; Prescutti, K.; Ball, O.; Chang, E.; Darakananda, K.; Jessup, K.; Poutian, J.; Schwalbe, H.; Storm, E.

    2008-12-01

    The Sustainable Seas Student Monitoring Project at the Branson School in Ross, CA has monitored Duxbury Reef in Bolinas, CA since 1999, in cooperation with the Farallones Marine Sanctuary Association and the Gulf of Farallones National Marine Sanctuary. Goals of the project include: 1) To monitor the rocky intertidal habitat and develop a baseline database of invertebrates and algal density and abundance; 2) To contribute to the conservation of the rocky intertidal habitat through education of students and visitors about intertidal species and requirements for maintaining a healthy, diverse intertidal ecosystem; 3) To increase stewardship in the Gulf of the Farallones National Marine Sanctuary; and 4) To contribute abundance and population data on key algae and invertebrate species to the national database, LiMPETS (Long Term Monitoring Program and Experiential Training for Students). Student volunteers complete an intensive training course on the natural history of intertidal invertebrates and algae, identification of key species, rocky intertidal ecology, interpretation and monitoring techniques, and history of the sanctuary. Students identify and count key invertebrate and algae species along two permanent transects (A and B), and using randomly determined points within a permanent 100 m2 area, three times per year (fall, winter, and late spring). Using the data collected since 2004, we will analyze the population densities of aggregating anemones, Anthopleura elegantissima, for seasonal abundance variations as well as long-term population trends. We will also follow the seasonal and long-term population fluctuations of red algal turf, Endocladia muricata and Gelidium coulteri, and black turban snails, Tegula funebralis. Comparing populations of turf algae and the herbivorous black turban snails gathered before and after the November 7, 2007 San Francisco Bay oil spill shows very little impact on the Duxbury Reef intertidal inhabitants. Future analyses will

  5. INTRACELLULAR Ca2+ HOMEOSTASIS

    Directory of Open Access Journals (Sweden)

    Shahdevi Nandar Kurniawan

    2015-01-01

    Full Text Available Ca2+ signaling functions to regulate many cellular processes. Dynamics of Ca2+ signaling or homeostasis is regulated by the interaction between ON and OFF reactions that control Ca2+ flux in both the plasma membrane and internal organelles such as the endoplasmic reticulum (ER and mitochondria. External stimuli activate the ON reactions, which include Ca2+ into the cytoplasm either through channels in the plasma membrane or from internal storage like in ER. Most of the cells utilize both channels/sources, butthere area few cells using an external or internal source to control certain processes. Most of the Ca2+ entering the cytoplasm adsorbed to the buffer, while a smaller part activate effect or to stimulate cellular processes. Reaction OFF is pumping of cytoplasmic Ca2+ using a combination mechanism of mitochondrial and others. Changes in Ca2+ signal has been detected in various tissues isolated from animals induced into diabetes as well as patients with diabetes. Ca2+ signal interference is also found in sensory neurons of experimental animals with diabetes. Ca2+ signaling is one of the main signaling systems in the cell.

  6. Israel’s Attack on Osiraq: A Model for Future Preventive Strikes?

    Science.gov (United States)

    2004-09-01

    a handwritten letter to the Italian Foreign Minister, Emilio Colombo in hopes of convincing Colombo and Italy to refrain from helping Iraq’s nuclear...Technical Information Center Ft. Belvoir, Virginia 2. Dudley Knox Library Naval Postgraduate School Monterey, California 3. Major Peter Ford Las Vegas , Nevada

  7. Your Town Television Show: SMART Program (Part 1) [video

    OpenAIRE

    Naval Postgraduate School, (U.S.); Sanders, John; Millsaps, Knox; Shifflett, Deborah

    2010-01-01

    From "Your Town" television show. SMART Scholarship Program featured on Your Town television program in Monterey, California. Host John Sanders, Special Collections Manager of the Naval Postgraduate School's Dudley Knox Library, interviews Dr. Knox Millsaps, Executive Agent for the SMART Program, and Deborah Shifflett, SMART Program Manager.

  8. Your Town Television Show: SMART Program (Part 3) [video

    OpenAIRE

    Naval Postgraduate School, (U.S.); Sanders, John; Millsaps, Knox; Shifflett, Deborah

    2010-01-01

    From "Your Town" television show. SMART Scholarship Program featured on Your Town television program in Monterey, California. Host John Sanders, Special Collections Manager of the Naval Postgraduate School's Dudley Knox Library, interviews Dr. Knox Millsaps, Executive Agent for the SMART Program, and Deborah Shifflett, SMART Program Manager.

  9. Toward Clarity on Understanding Tropical Cyclone Intensification

    Science.gov (United States)

    2015-08-01

    Munich, Germany MICHAEL T. MONTGOMERY Department of Meteorology, Naval Postgraduate School , Monterey, California (Manuscript received 13 January 2015...PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School ,Department of...Fig. 1b of Chen and Zhang (2013), which shows time series of minimum surface pressure from a simulation of Hurri- cane Wilma (2005), obtained by

  10. The Azimuthally Averaged Boundary Layer Structure of a Numerically Simulated Major Hurricane

    Science.gov (United States)

    2015-08-14

    Michael T. Montgomery2, and James C. McWilliams3 1IMSG at NOAA/NWS/NCEP, College Park, Maryland, USA, 2Naval Postgraduate School , Monterey...definitions of the hurricane boundary layer are uncontroversial in the outer regions of a hurri- cane , where convection is not prevalent and there is...support from the National Research Council (NRC) through its Research Associateship Program, and the host institution, the Naval Postgraduate School (NPS

  11. Various Effects of Embedded Intrapulse Communications on Pulsed Radar

    Science.gov (United States)

    2017-06-01

    the degree of MASTER OF SCIENCE IN ELECTRICAL ENGINEERING from the NAVAL POSTGRADUATE SCHOOL June 2017 Approved by: Ric A. Romero Thesis Co-Advisor...the shape of the radar signal in the frequency domain, differing only in magnitude. The PSDs for the communications signal alone at various RCR levels ...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS VARIOUS EFFECTS OF EMBEDDED INTRAPULSE COMMUNICATIONS ON PULSED RADAR by Allison Hunt June 2017

  12. F-actin-based Ca signaling-a critical comparison with the current concept of Ca signaling.

    Science.gov (United States)

    Lange, Klaus; Gartzke, Joachim

    2006-11-01

    A short comparative survey on the current idea of Ca signaling and the alternative concept of F-actin-based Ca signaling is given. The two hypotheses differ in one central aspect, the mechanism of Ca storage. The current theory rests on the assumption of Ca-accumulating endoplasmic/sarcoplasmic reticulum-derived vesicles equipped with an ATP-dependent Ca pump and IP3- or ryanodine-sensitive channel-receptors for Ca-release. The alternative hypothesis proceeds from the idea of Ca storage at the high-affinity binding sites of actin filaments. Cellular sites of F-actin-based Ca storage are microvilli and the submembrane cytoskeleton. Several specific features of Ca signaling such as store-channel coupling, quantal Ca release, spiking and oscillations, biphasic and "phasic" uptake kinetics, and Ca-induced Ca release (CICR), which are not adequately described by the current concept, are inherent properties of the F-actin system and its dynamic state of treadmilling. Copyright 2006 Wiley-Liss, Inc.

  13. MicroRNA-145 suppresses ROS-induced Ca2+ overload of cardiomyocytes by targeting CaMKIIδ

    International Nuclear Information System (INIS)

    Cha, Min-Ji; Jang, Jin-Kyung; Ham, Onju; Song, Byeong-Wook; Lee, Se-Yeon; Lee, Chang Yeon; Park, Jun-Hee; Lee, Jiyun; Seo, Hyang-Hee; Choi, Eunhyun; Jeon, Woo-min; Hwang, Hye Jin; Shin, Hyun-Taek

    2013-01-01

    Highlights: •CaMKIIδ mediates H 2 O 2 -induced Ca 2+ overload in cardiomyocytes. •miR-145 can inhibit Ca 2+ overload. •A luciferase assay confirms that miR-145 functions as a CaMKIIδ-targeting miRNA. •Overexpression of miR-145 regulates CaMKIIδ-related genes and ameliorates apoptosis. -- Abstract: A change in intracellular free calcium (Ca 2+ ) is a common signaling mechanism of reperfusion-induced cardiomyocyte death. Calcium/calmodulin dependent protein kinase II (CaMKII) is a critical regulator of Ca 2+ signaling and mediates signaling pathways responsible for functions in the heart including hypertrophy, apoptosis, arrhythmia, and heart disease. MicroRNAs (miRNA) are involved in the regulation of cell response, including survival, proliferation, apoptosis, and development. However, the roles of miRNAs in Ca 2+ -mediated apoptosis of cardiomyocytes are uncertain. Here, we determined the potential role of miRNA in the regulation of CaMKII dependent apoptosis and explored its underlying mechanism. To determine the potential roles of miRNAs in H 2 O 2 -mediated Ca 2+ overload, we selected and tested 6 putative miRNAs that targeted CaMKIIδ, and showed that miR-145 represses CaMKIIδ protein expression and Ca 2+ overload. We confirmed CaMKIIδ as a direct downstream target of miR-145. Furthermore, miR-145 regulates Ca 2+ -related signals and ameliorates apoptosis. This study demonstrates that miR-145 regulates reactive oxygen species (ROS)-induced Ca 2+ overload in cardiomyocytes. Thus, miR-145 affects ROS-mediated gene regulation and cellular injury responses

  14. Changes in the expression of serum markers CA242, CA199, CA125, CEA, TNF-α and TSGF after cryosurgery in pancreatic cancer patients.

    Science.gov (United States)

    Zhou, Gang; Niu, Lizhi; Chiu, David; He, Lihua; Xu, Kecheng

    2012-07-01

    The presence of serum tumor markers, carbohydrate antigen 242 (CA242), carbohydrate antigen 199 (CA199), carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA), tumor-supplied group of factors (TSGF) and tumor necrosis factor-α (TNF-α), is closely associated with invasion and metastasis of many malignancies. The expression of these markers were measured in serum taken from 37 pancreatic cancer patients prior to treatment. Levels of CA242, CA199, CA125, CEA and TNF-α expression correlated with tumor size, clinical stage, tumor differentiation, lymph node and liver metastasis (P markers were significantly reduced compared with levels prior to cryosurgery (P 0.05). Thus, cryosurgery is more effective than chemotherapy for decreasing CA242, CA199, CA125, CEA, TSGF and TNF-α serum levels in these patients.

  15. Regulated release of Ca2+ from respiring mitochondria by Ca2+/2H+ antiport.

    Science.gov (United States)

    Fiskum, G; Lehninger, A L

    1979-07-25

    Simultaneous measurements of oxygen consumption and transmembrane transport of Ca2+, H+, and phosphate show that the efflux of Ca2+ from respiring tightly coupled rat liver mitochondria takes place by an electroneutral Ca2+/2H+ antiport process that is ruthenium red-insensitive and that is regulated by the oxidation-reduction state of the mitochondrial pyridine nucleotides. When mitochondrial pyridine nucleotides are kept in a reduced steady state, the efflux of Ca2+ is inhibited; when they are in an oxidized state, Ca2+ efflux is activated. These processes were demonstrated by allowing phosphate-depleted mitochondria respiring on succinate in the presence of rotenone to take up Ca2+ from the medium. Upon subsequent addition of ruthenium red to block Ca2+ transport via the electrophoretic influx pathway, and acetoacetate, to bring mitochondrial pyridine nucleotides into the oxidized state, Ca2+ efflux and H+ influx ensued. The observed H+ influx/Ca2+ efflux ratio was close to the value 2.0 predicted for the operation of an electrically neutral Ca2+/2H+ antiport process.

  16. Applicative Value of Serum CA19-9, CEA, CA125 and CA242 in Diagnosis and Prognosis for Patients with Pancreatic Cancer Treated by Concurrent Chemoradiotherapy.

    Science.gov (United States)

    Gu, Yu-Lei; Lan, Chao; Pei, Hui; Yang, Shuang-Ning; Liu, Yan-Fen; Xiao, Li-Li

    2015-01-01

    To evaluate the application value of serum CA19-9, CEA, CA125 and CA242 in diagnosis and prognosis of pancreatic cancer cases treated with concurrent chemotherapy. 52 patients with pancreatic cancer, 40 with benign pancreatic diseases and 40 healthy people were selected. The electrochemiluminescence immunoassay method was used for detecting levels of CA19-9, CEA and CA125, and a CanAg CA242 enzyme linked immunoassay kit for assessing the level of CA242. The Kaplan-Meier method was used for analyzing the prognostic factors of patients with pancreatic cancer. The Cox proportional hazard model was applied for analyzing the hazard ratio (HR) and 95% confidential interval (CI) for survival time of patients with pancreatic cancer. The levels of serum CA19-9, CEA, CA125 and CA242 in patients with pancreatic cancer were significantly higher than those in patients with benign pancreatic diseases and healthy people (PCEA. The specificity of CA242 is the highest, followed by CA125, CEA and CA19-9. The sensitivity and specificity of joint detection of serum CA19-9, CEA, CA125and CA242 were 90.4% and 93.8%, obviously higher than single detection of those markers in diagnosis of pancreatic cancer. The median survival time of 52 patients with pancreatic cancer was 10 months (95% CI7.389~12.611).. Patients with the increasing level of serum CA19-9, CEA, CA125, CA242 had shorter survival times (P=0.047. 0.043, 0.0041, 0.029). COX regression analysis showed that CA19-9 was an independent prognostic factor for patients with pancreatic cancer (P=0.001, 95%CI 2.591~38.243). The detection of serum tumor markers (CA19.9, CEA, CA125 and CA242) is conducive to the early diagnosis of pancreatic cancer and joint detection of tumor markers helps improve the diagnostic efficiency. Moreover, CA19-9 is an independent prognostic factor for patients with pancreatic cancer.

  17. NOAA Office for Coastal Management Coastal Inundation Digital Elevation Model: San Francisco Bay/Monterey (CA) WFO - Santa Cruz and Monterey Counties

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This digital elevation model (DEM) is a part of a series of DEMs produced for the National Oceanic and Atmospheric Administration Office for Coastal Management's Sea...

  18. Use of Cutting-Edge Horizontal and Underbalanced Drilling Technologies and Subsurface Seismic Techniques to Explore, Drill and Produce Reservoired Oil and Gas from the Fractured Monterey Below 10,000 ft in the Santa Maria Basin of California

    Energy Technology Data Exchange (ETDEWEB)

    George Witter; Robert Knoll; William Rehm; Thomas Williams

    2006-06-30

    This project was undertaken to demonstrate that oil and gas can be drilled and produced safely and economically from a fractured Monterey reservoir in the Santa Maria Basin of California by employing horizontal wellbores and underbalanced drilling technologies. Two vertical wells were previously drilled in this area with heavy mud and conventional completions; neither was commercially productive. A new well was drilled by the project team in 2004 with the objective of accessing an extended length of oil-bearing, high-resistivity Monterey shale via a horizontal wellbore, while implementing managed-pressure drilling (MPD) techniques to avoid formation damage. Initial project meetings were conducted in October 2003. The team confirmed that the demonstration well would be completed open-hole to minimize productivity impairment. Following an overview of the geologic setting and local field experience, critical aspects of the application were identified. At the pre-spud meeting in January 2004, the final well design was confirmed and the well programming/service company requirements assigned. Various design elements were reduced in scope due to significant budgetary constraints. Major alterations to the original plan included: (1) a VSP seismic survey was delayed to a later phase; (2) a new (larger) surface hole would be drilled rather than re-enter an existing well; (3) a 7-in. liner would be placed into the top of the Monterey target as quickly as possible to avoid problems with hole stability; (4) evaluation activities were reduced in scope; (5) geosteering observations for fracture access would be deduced from penetration rate, cuttings description and hydrocarbon in-flow; and (6) rather than use nitrogen, a novel air-injection MPD system was to be implemented. Drilling operations, delayed from the original schedule by capital constraints and lack of rig availability, were conducted from September 12 to November 11, 2004. The vertical and upper curved sections were

  19. Modeling, Simulation, and Operations Analysis in Afghanistan and Iraq: Operational Vignettes, Lessons Learned, and a Survey of Selected Efforts

    Science.gov (United States)

    2014-01-01

    1990s and early 2000s-era concept of System-of-Systems Analysis that remains prevalent in current doctrine. Some argue that the AtN theory can be...delivered to the Naval Postgraduate School, Monterey, Calif., October 2011. Armstrong, Nicholas J., and Jacqueline Chura- Beaver , “Harnessing Post

  20. An Intelligent Assistant for Construction of Terrain Databases

    OpenAIRE

    Rowe, Neil C.; Reed, Chris; Jackson, Leroy; Baer, Wolfgang

    1998-01-01

    1998 Command and Control Research and Technology Symposium, Monterey CA, June 1998, 481-486. We describe TELLUSPLAN, an intelligent assistant for the problem of bargaining between user goals and system resources in the integration of terrain databases from separate source databases. TELLUSPLAN uses nondeterministic methods from artificial intelligence and a detailed cost model to infer the most reasonable compromise with the user's needs. Supported by the Army Artificial Int...

  1. Comparison of polarimetric cameras

    Science.gov (United States)

    2017-03-01

    Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and to the Office of Management and Budget , Paperwork Reduction Project (0704-0188...polarimetric camera, remote sensing, space systems 15. NUMBER OF PAGES 93 16. PRICE CODE 17. SECURITY CLASSIFICATION OF REPORT Unclassified 18...2016. Hermann Hall, Monterey, CA. The next data in Figure 37. were collected on 01 December 2016 at 1226 PST on the rooftop of the Marriot Hotel in

  2. School-based assessments in high-stakes examinations in Bhutan: a question of trust? : exploring inconsistencies between external exam scores, school-based assessments, detailed teacher ratings, and student self-ratings

    NARCIS (Netherlands)

    Luyten, Johannes W.; Dolkar, Dechen

    2010-01-01

    This study explores the validity of school-based assessments when they serve to supplement scores on central tests in high-stakes examinations. The school-based continuous assessment (CA) marks are compared to the marks scored on the central written Bhutan Certificate of Secondary Education (BCSE)

  3. The CaV2.3 R-type voltage-gated Ca2+ channel in mouse sleep architecture.

    Science.gov (United States)

    Siwek, Magdalena Elisabeth; Müller, Ralf; Henseler, Christina; Broich, Karl; Papazoglou, Anna; Weiergräber, Marco

    2014-05-01

    Voltage-gated Ca(2+) channels (VGCCs) are key elements in mediating thalamocortical rhythmicity. Low-voltage activated (LVA) CaV 3 T-type Ca(2+) channels have been related to thalamic rebound burst firing and to generation of non-rapid eye movement (NREM) sleep. High-voltage activated (HVA) CaV 1 L-type Ca(2+) channels, on the opposite, favor the tonic mode of action associated with higher levels of vigilance. However, the role of the HVA Non-L-type CaV2.3 Ca(2+) channels, which are predominantly expressed in the reticular thalamic nucleus (RTN), still remains unclear. Recently, CaV2.3(-/-) mice were reported to exhibit altered spike-wave discharge (SWD)/absence seizure susceptibility supported by the observation that CaV2.3 mediated Ca(2+) influx into RTN neurons can trigger small-conductance Ca(2+)-activated K(+)-channel type 2 (SK2) currents capable of maintaining thalamic burst activity. Based on these studies we investigated the role of CaV2.3 R-type Ca(2+) channels in rodent sleep. The role of CaV2.3 Ca(2+) channels was analyzed in CaV2.3(-/-) mice and controls in both spontaneous and artificial urethane-induced sleep, using implantable video-EEG radiotelemetry. Data were analyzed for alterations in sleep architecture using sleep staging software and time-frequency analysis. CaV2.3 deficient mice exhibited reduced wake duration and increased slow-wave sleep (SWS). Whereas mean sleep stage durations remained unchanged, the total number of SWS epochs was increased in CaV2.3(-/-) mice. Additional changes were observed for sleep stage transitions and EEG amplitudes. Furthermore, urethane-induced SWS mimicked spontaneous sleep results obtained from CaV2.3 deficient mice. Quantitative Real-time PCR did not reveal changes in thalamic CaV3 T-type Ca(2+) channel expression. The detailed mechanisms of SWS increase in CaV2.3(-/-) mice remain to be determined. Low-voltage activated CaV2.3 R-type Ca(2+) channels in the thalamocortical loop and extra

  4. Institutional influences on the provision of after-school nature programs

    Science.gov (United States)

    James D. Absher; Anne S. Fege; Leanne Jacobson

    2015-01-01

    This study examines the institutional factors that affect organizations' decisions to offer after-school nature programs. Data are from interviews of 31 staff and administrators of after-school programs in San Diego, CA. Results show support for the importance of nature education experiences in general, and that such activities are more likely to be offered if...

  5. The self-report Version of the LSAS-CA: Psychometric Properties of the French Version in a non-clinical adolescent sample

    Directory of Open Access Journals (Sweden)

    Emilie Schmits

    2014-02-01

    Full Text Available The Liebowitz Social Anxiety Scale (LSAS is one of the most popular measures of social anxiety in adults. The LSAS has been adapted for clinical assessment of children and adolescents (LSAS-CA. The psychometric properties of the self-report version of the LSAS-CA (LSAS-CA-SR have been investigated in a Spanish population. However, no study to date has adapted and validated this scale in French. The purpose of this study was to develop a French version of the LSAS-CA-SR and to assess its score reliability and structural validity in a French-speaking community sample. The sample was made up of 1,343 teenagers from secondary schools, aged between 14 and 18 years. Confirmatory factor analyses established the structural validity of the French version of the LSAS-CA-SR and good psychometric properties, including reliable internal consistency, were observed.

  6. Analysis of Central Design Agency Alternatives for Navy Industrial Fund Accounting Systems: A Proposed Methodology.

    Science.gov (United States)

    1980-03-01

    Postgraduate School ANA01611I NM61"fa Monterey, California 93940 1 CON TROLLING OFFICE NAMC &NO Accaes ii uOmvo*a Naval Postgraduate School March 1980...judge alternative 3, it is further recomended that the Naval Audit Service, private contractor or other independent agent be comissioned to perform an in...Government Accounting, Government Accounting, Auditing , and Financial Reporting, Chicago, Municipal Finance Officer’s Association, 1968, p. 3-4. 4

  7. Rates for some reactions involving 42Ca and 44Ca

    International Nuclear Information System (INIS)

    Cheng, C.W.; King, J.D.

    1980-01-01

    Ground-state reaction rates have been deduced from recent cross section measurements for the 42 CA(α, n) 45 Ti, 42 Ca(p, γ) 43 Sc, and 44 Ca(p, n) 44 Sc reactions. Comparison of these rates with those calculated from a statistical model of nuclear reactions. (Woosley et al) shows good agreement for the first two, but the 44 Ca(p, n) rate is more than a factor of 2 less than the theoretical prediction. Stellar reaction rates have been derived from the ground-state rates by multiplying the ground-state rates by the ratio of stellar to ground-state rates given by the statistical model. Both ground-state and stellar rates have been represented by analytic functions of the temperature. The role of these reactions in the approach to quasi-equilibrium during explosive silicon burning is discussed

  8. Mg-Ca Alloys Produced by Reduction of CaO: Understanding of ECO-Mg Alloy Production

    Science.gov (United States)

    Jung, In-Ho; Lee, Jin Kyu; Kim, Shae K.

    2017-04-01

    There have been long debates about the environment conscious (ECO) Mg technology which utilizes CaO to produce Ca-containing Mg alloys. Two key process technologies of the ECO-Mg process are the chemical reduction of CaO by liquid Mg and the maintenance of melt cleanliness during the alloying of Ca. Thermodynamic calculations using FactSage software were performed to explain these two key issues. In addition, an experimental study was performed to compare the melt cleanliness of the Ca-containing Mg alloys produced by the conventional route with metallic Ca and the ECO-Mg route with CaO.

  9. The study of skeletal calcium metabolism with 41Ca and 45Ca

    Science.gov (United States)

    Freeman, Stewart P. H. T.; Beck, Belinda; Bierman, June M.; Caffee, Marc W.; Heaney, Robert P.; Holloway, Leah; Marcus, Robert; Southon, John R.; Vogel, John S.

    2000-10-01

    The living skeleton can be labeled for life by the administration of radiologically trivial amounts of 41Ca tracer. After initial elimination of tracer from the readily exchangeable calcium pools subsequent skeletal calcium turnover maintains and modulates the urine 41Ca content. Uniquely, bone calcium metabolism may then be studied with tracer in near equilibrium with the body's calcium and resorbing calcium directly measured by accelerator mass spectrometry (AMS) of excreta. Our experiments with 25 41Ca labeled subjects demonstrate excellent diurnal stability and remarkable response to intervention of the urine signal. Thus the tracer method may prove a competitive means of measuring the effects of antiresorptive osteoporosis treatments, for therapy development or even clinical monitoring. Novel studies of long-term skeletal evolution are also possible. We realize that routinely administered short-lived calcium radiotracers contain 41Ca impurities and that thousands of experimental participants have been historically inadvertently 41Ca labeled. The 41Ca urine index might now rapidly further be characterized by contemporary measurements of these one-time subjects, and with their by now thoroughly skeleton-equilibrated tracer they might be ideal participants in other new experiments. We are also investigating 45Ca AMS. It may prove preferable to label the skeleton with this radiotracer already familiar to bioscientists, but new to AMS.

  10. Fleet Readiness Center Mid-Atlantic Worker Cost Comparison

    Science.gov (United States)

    2012-06-01

    Depreciation ........................................................................................33  VI.  METHODOLOGY ...Nussbaum is professor at the Department of Operations Reserach at the Naval Postgraduate School in Monterey, California (Nussbaum, 2000). 24 THIS PAGE...data received from FRCMA Oceana. 38 THIS PAGE INTENTIONALLY LEFT BLANK 39 VI. METHODOLOGY A. LIMITS OF RESEARCH Most financial and managerial

  11. Successful and Practical Intercultural Communication Techniques.

    Science.gov (United States)

    Dresser, Cynthia H.

    Techniques for teaching students to use a variety of language and communication skills to improve participation and success in cross-cultural situations are outlined. The approach evolved in the context of the Naval Postgraduate School at Monterey, California, in which foreign military officers must learn strategies for effective communication in…

  12. MicroRNA-145 suppresses ROS-induced Ca{sup 2+} overload of cardiomyocytes by targeting CaMKIIδ

    Energy Technology Data Exchange (ETDEWEB)

    Cha, Min-Ji [Cardiovascular Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Jang, Jin-Kyung [College of Pharmacy, Sookmyung Women’s University, 52 HyoChangWon-Gil, Yongsan-ku, Seoul 140-742 (Korea, Republic of); Ham, Onju; Song, Byeong-Wook; Lee, Se-Yeon [Cardiovascular Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Lee, Chang Yeon; Park, Jun-Hee [Department of Integrated Omics for Biomedical Sciences, Graduate School, Yonsei University, 50 Yonsei-ro, Seodamun-gu, Seoul 120-759 (Korea, Republic of); Lee, Jiyun; Seo, Hyang-Hee [Cardiovascular Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Choi, Eunhyun [Severance Integrative Research Institute for Cerebral and Cardiovascular Disease, Yonsei University Health System, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Jeon, Woo-min [Department of Animal Resource, Sahmyook University, Seoul 139-742 (Korea, Republic of); Hwang, Hye Jin [Cardiovascular Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Shin, Hyun-Taek [College of Pharmacy, Sookmyung Women’s University, 52 HyoChangWon-Gil, Yongsan-ku, Seoul 140-742 (Korea, Republic of); and others

    2013-06-14

    Highlights: •CaMKIIδ mediates H{sub 2}O{sub 2}-induced Ca{sup 2+} overload in cardiomyocytes. •miR-145 can inhibit Ca{sup 2+} overload. •A luciferase assay confirms that miR-145 functions as a CaMKIIδ-targeting miRNA. •Overexpression of miR-145 regulates CaMKIIδ-related genes and ameliorates apoptosis. -- Abstract: A change in intracellular free calcium (Ca{sup 2+}) is a common signaling mechanism of reperfusion-induced cardiomyocyte death. Calcium/calmodulin dependent protein kinase II (CaMKII) is a critical regulator of Ca{sup 2+} signaling and mediates signaling pathways responsible for functions in the heart including hypertrophy, apoptosis, arrhythmia, and heart disease. MicroRNAs (miRNA) are involved in the regulation of cell response, including survival, proliferation, apoptosis, and development. However, the roles of miRNAs in Ca{sup 2+}-mediated apoptosis of cardiomyocytes are uncertain. Here, we determined the potential role of miRNA in the regulation of CaMKII dependent apoptosis and explored its underlying mechanism. To determine the potential roles of miRNAs in H{sub 2}O{sub 2}-mediated Ca{sup 2+} overload, we selected and tested 6 putative miRNAs that targeted CaMKIIδ, and showed that miR-145 represses CaMKIIδ protein expression and Ca{sup 2+} overload. We confirmed CaMKIIδ as a direct downstream target of miR-145. Furthermore, miR-145 regulates Ca{sup 2+}-related signals and ameliorates apoptosis. This study demonstrates that miR-145 regulates reactive oxygen species (ROS)-induced Ca{sup 2+} overload in cardiomyocytes. Thus, miR-145 affects ROS-mediated gene regulation and cellular injury responses.

  13. Structural, electronic, elastic, and thermodynamic properties of CaSi, Ca2Si, and CaSi2 phases from first-principles calculations

    Science.gov (United States)

    Li, X. D.; Li, K.; Wei, C. H.; Han, W. D.; Zhou, N. G.

    2018-06-01

    The structural, electronic, elastic, and thermodynamic properties of CaSi, Ca2Si, and CaSi2 are systematically investigated by using first-principles calculations method based on density functional theory (DFT). The calculated formation enthalpies and cohesive energies show that CaSi2 possesses the greatest structural stability and CaSi has the strongest alloying ability. The structural stability of the three phases is compared according to electronic structures. Further analysis on electronic structures indicates that the bonding of these phases exhibits the combinations of metallic, covalent, and ionic bonds. The elastic constants are calculated, and the bulk modulus, shear modulus, Young's modulus, Poisson's ratio, and anisotropy factor of polycrystalline materials are deduced. Additionally, the thermodynamic properties were theoretically predicted and discussed.

  14. Accessing the nuclear symmetry energy in Ca+Ca collisions

    Directory of Open Access Journals (Sweden)

    Chbihi A.

    2012-07-01

    Full Text Available The status of the analysis of the INDRA-VAMOS experiement performed at GANIL, using the reactions 40,48Ca+40,48Ca reactions at 35AMeV, are presented. Isotopic distributions of fragments produced in multifragmentation events provide information on the importance of the surface term contribution in the symmetry energy by comparison to AMD predictions.

  15. Cost Analysis of a Transition to Green Vehicle Technology for Light Duty Fleet Vehicles in Public Works Department Naval Support Activity Monterey (PWD Monterey)

    Science.gov (United States)

    2015-12-01

    price of the hybrid vehicle. Many consumers will view the idea of paying more initially to save on gasoline costs down the road as not worthwhile...braking and electricity generation from an ICE. Similar to the HEV, upon purchase of a PHEV, the consumer may take advantage of the green vehicle tax ... electric cards and Hybrids? (2015, November 3). Retrieved from Plug’n Drive website: https://www.plugndrive.ca/whats- the-difference-between- electric - cars

  16. Ca2+ cycling in heart cells from ground squirrels: adaptive strategies for intracellular Ca2+ homeostasis.

    Directory of Open Access Journals (Sweden)

    Xiao-Chen Li

    Full Text Available Heart tissues from hibernating mammals, such as ground squirrels, are able to endure hypothermia, hypoxia and other extreme insulting factors that are fatal for human and nonhibernating mammals. This study was designed to understand adaptive mechanisms involved in intracellular Ca(2+ homeostasis in cardiomyocytes from the mammalian hibernator, ground squirrel, compared to rat. Electrophysiological and confocal imaging experiments showed that the voltage-dependence of L-type Ca(2+ current (I(Ca was shifted to higher potentials in ventricular myocytes from ground squirrels vs. rats. The elevated threshold of I(Ca did not compromise the Ca(2+-induced Ca(2+ release, because a higher depolarization rate and a longer duration of action potential compensated the voltage shift of I(Ca. Both the caffeine-sensitive and caffeine-resistant components of cytosolic Ca(2+ removal were more rapid in ground squirrels. Ca(2+ sparks in ground squirrels exhibited larger amplitude/size and much lower frequency than in rats. Due to the high I(Ca threshold, low SR Ca(2+ leak and rapid cytosolic Ca(2+ clearance, heart cells from ground squirrels exhibited better capability in maintaining intracellular Ca(2+ homeostasis than those from rats and other nonhibernating mammals. These findings not only reveal adaptive mechanisms of hibernation, but also provide novel strategies against Ca(2+ overload-related heart diseases.

  17. Mg and Ca isotope fractionation during CaCO3 biomineralisation

    International Nuclear Information System (INIS)

    Chang, Veronica T.-C.; Williams, R.J.P.; Makishima, Akio; Belshawl, Nick S.; O'Nions, R. Keith

    2004-01-01

    The natural variation of Mg and Ca stable isotopes of carbonates has been determined in carbonate skeletons of perforate foraminifera and reef coral together with Mg/Ca ratios to assess the influence of biomineralisation processes. The results for coral aragonite suggest its formation, in terms of stable isotope behaviour, approximates to inorganic precipitation from a seawater reservoir. In contrast, results for foraminifera calcite suggest a marked biological control on Mg isotope ratios presumably related to its low Mg content compared with seawater. The bearing of these observations on the use of Mg and Ca isotopes as proxies in paleoceanography is considered

  18. ORIGINAL ARTICLE Primary School Teachers' Knowledge, Attitude ...

    African Journals Online (AJOL)

    user

    Thus, it was recommended that teachers be given on-job training about CA ... 1Professor, Department of English, Faculty of Humanities, Bahir Dar University,. Ethiopia. .... psychomotor developments and uses variety of instruments ..... Table 3. Primary school teachers' responses about the advantages and disadvantages of.

  19. Effects of Ca on microstructure, mechanical and corrosion properties and biocompatibility of Mg-Zn-Ca alloys.

    Science.gov (United States)

    Yin, Ping; Li, Nian Feng; Lei, Ting; Liu, Lin; Ouyang, Chun

    2013-06-01

    Zn and Ca were selected as alloying elements to develop an Mg-Zn-Ca alloy system for biomedical application due to their good biocompatibility. The effects of Ca on the microstructure, mechanical and corrosion properties as well as the biocompatibility of the as-cast Mg-Zn-Ca alloys were studied. Results indicate that the microstructure of Mg-Zn-Ca alloys typically consists of primary α-Mg matrix and Ca₂Mg₆Zn₃/Mg₂Ca intermetallic phase mainly distributed along grain boundary. The yield strength of Mg-Zn-Ca alloy increased slightly with the increase of Ca content, whilst its tensile strength increased at first and then decreased. Corrosion tests in the simulated body fluid revealed that the addition of Ca is detrimental to corrosion resistance due to the micro-galvanic corrosion acceleration. In vitro hemolysis and cytotoxicity assessment disclose that Mg-5Zn-1.0Ca alloy has suitable biocompatibility.

  20. The diagnostic value of serum tumor markers CEA, CA19-9, CA125, CA15-3, and TPS in metastatic breast cancer.

    Science.gov (United States)

    Wang, Weigang; Xu, Xiaoqin; Tian, Baoguo; Wang, Yan; Du, Lili; Sun, Ting; Shi, Yanchun; Zhao, Xianwen; Jing, Jiexian

    2017-07-01

    This study aims to understand the diagnostic value of serum tumor markers carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9), cancer antigen 125 (CA125), cancer antigen 15-3 (CA15-3), and tissue polypeptide-specific antigen (TPS) in metastatic breast cancer (MBC). A total of 164 metastatic breast cancer patients in Shanxi Cancer Hospital were recruited between February 2016 and July 2016. 200 breast cancer patients without metastasis in the same period were randomly selected as the control group. The general characteristics, immunohistochemical, and pathological results were investigated between the two groups, and tumor markers were determined. There were statistical differences in the concentration and the positive rates of CEA, CA19-9, CA125, CA15-3, and TPS between the MBC and control group (Ptumor marker at 56.7% and 97.0%, respectively. In addition, two tumor markers were used for the diagnosis of MBC and the CEA and TPS combination had the highest diagnostic sensitivity with 78.7%, while the CA15-3 and CA125 combination had the highest specificity of 91.5%. Analysis of tumor markers of 164 MBC found that there were statistical differences in the positive rates of CEA and CA15-3 between bone metastases and other metastases (χ 2 =6.00, P=0.014; χ 2 =7.32, P=0.007, respectively). The sensitivity and specificity values of the CEA and CA15-3 combination in the diagnosis of bone metastases were 77.1% and 45.8%, respectively. The positive rate of TPS in the lung metastases group was lower than in other metastases (χ 2 =8.06, P=0.005).There were significant differences in the positive rates of CA15-3 and TPS between liver metastases and other metastases (χ 2 =15.42, Ptumor markers have varying diagnostic value. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. New limits on 2β processes in 40Ca and 46Ca by using low radioactive CaF2(Eu) crystal scintillators

    International Nuclear Information System (INIS)

    Belli, P.; Bernabei, R.; Dai, C.J.

    2001-01-01

    The development of highly radiopure CaF 2 (Eu) crystal scintillators has been performed aiming at a substantial sensitivity enhancement of the 2β decay investigation and of the search for dark matter particles with spin-dependent (SD) interaction. The results of CaF 2 (Eu) background measurements and simulation are presented. New and highly improved T 1/2 limits on the 2β decay of 46 Ca and the double electron capture of 40 Ca are obtained

  2. Impact of seawater [Ca

    NARCIS (Netherlands)

    Mewes, A.; Langer, G.; Thoms, S.; Nehrke, G.; Reichart, G.J.; de Nooijer, L.J.; Bijma, J.

    2015-01-01

    Mg / Ca ratios in foraminiferal tests are routinely used as paleotemperature proxies, but on long timescales, they also hold the potential to reconstruct past seawater Mg / Ca. The impact of both temperature and seawater Mg / Ca on Mg incorporation in Foraminifera has been quantified by a number of

  3. CaV 3.1 and CaV 3.3 account for T-type Ca2+ current in GH3 cells

    Directory of Open Access Journals (Sweden)

    M.A. Mudado

    2004-06-01

    Full Text Available T-type Ca2+ channels are important for cell signaling by a variety of cells. We report here the electrophysiological and molecular characteristics of the whole-cell Ca2+ current in GH3 clonal pituitary cells. The current inactivation at 0 mV was described by a single exponential function with a time constant of 18.32 ± 1.87 ms (N = 16. The I-V relationship measured with Ca2+ as a charge carrier was shifted to the left when we applied a conditioning pre-pulse of up to -120 mV, indicating that a low voltage-activated current may be present in GH3 cells. Transient currents were first activated at -50 mV and peaked around -20 mV. The half-maximal voltage activation and the slope factors for the two conditions are -35.02 ± 2.4 and 6.7 ± 0.3 mV (pre-pulse of -120 mV, N = 15, and -27.0 ± 0.97 and 7.5 ± 0.7 mV (pre-pulse of -40 mV, N = 9. The 8-mV shift in the activation mid-point was statistically significant (P < 0.05. The tail currents decayed bi-exponentially suggesting two different T-type Ca2+ channel populations. RT-PCR revealed the presence of a1G (CaV3.1 and a1I (CaV3.3 T-type Ca2+ channel mRNA transcripts.

  4. Development of Control Algorithm for the Autonomous Gliding Delivery System

    OpenAIRE

    Kaminer, I.; Yakimenko, O.

    2003-01-01

    Proceedings of 17th AIAA Aerodynamic Decelerator Systems Technology Conference and Seminar, Monterey, CA, May 19-22, 2003. An autonomous HAHO (high altitude, high-opening) parafoil system design is presented as a solution to the final descent phase of an on-demand International Space Station (ISS) sample return concept. The system design is tailored to meet specific constraints defined by a larger study at NASA Ames Research Center, called SPQR (Small Payload Quick-Return). Building ...

  5. Coupled Ca2+/H+ transport by cytoplasmic buffers regulates local Ca2+ and H+ ion signaling.

    Science.gov (United States)

    Swietach, Pawel; Youm, Jae-Boum; Saegusa, Noriko; Leem, Chae-Hun; Spitzer, Kenneth W; Vaughan-Jones, Richard D

    2013-05-28

    Ca(2+) signaling regulates cell function. This is subject to modulation by H(+) ions that are universal end-products of metabolism. Due to slow diffusion and common buffers, changes in cytoplasmic [Ca(2+)] ([Ca(2+)]i) or [H(+)] ([H(+)]i) can become compartmentalized, leading potentially to complex spatial Ca(2+)/H(+) coupling. This was studied by fluorescence imaging of cardiac myocytes. An increase in [H(+)]i, produced by superfusion of acetate (salt of membrane-permeant weak acid), evoked a [Ca(2+)]i rise, independent of sarcolemmal Ca(2+) influx or release from mitochondria, sarcoplasmic reticulum, or acidic stores. Photolytic H(+) uncaging from 2-nitrobenzaldehyde also raised [Ca(2+)]i, and the yield was reduced following inhibition of glycolysis or mitochondrial respiration. H(+) uncaging into buffer mixtures in vitro demonstrated that Ca(2+) unloading from proteins, histidyl dipeptides (HDPs; e.g., carnosine), and ATP can underlie the H(+)-evoked [Ca(2+)]i rise. Raising [H(+)]i tonically at one end of a myocyte evoked a local [Ca(2+)]i rise in the acidic microdomain, which did not dissipate. The result is consistent with uphill Ca(2+) transport into the acidic zone via Ca(2+)/H(+) exchange on diffusible HDPs and ATP molecules, energized by the [H(+)]i gradient. Ca(2+) recruitment to a localized acid microdomain was greatly reduced during intracellular Mg(2+) overload or by ATP depletion, maneuvers that reduce the Ca(2+)-carrying capacity of HDPs. Cytoplasmic HDPs and ATP underlie spatial Ca(2+)/H(+) coupling in the cardiac myocyte by providing ion exchange and transport on common buffer sites. Given the abundance of cellular HDPs and ATP, spatial Ca(2+)/H(+) coupling is likely to be of general importance in cell signaling.

  6. Innovations for Requirements Engineering

    Science.gov (United States)

    2008-01-01

    bidding decision system. Trade Managemen t Production Management Cost Management Settlement Forecasting & Decision LDAS Electricity Market MDAS Figure...i NAVAL POSTGRADUATE SCHOOL Monterey, California 93943-5000 Daniel T . Oliver Leonard A. Ferrari...Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and to the Office of

  7. A Balanced Approach to Funding Homeland Security

    Science.gov (United States)

    2014-12-01

    Conflict Resolution 20 (1976): 143–172. 232 Fathali M. Moghaddam, Multiculturalism and Intergroup Relations (Washington, DC: American Psychological...M. Multiculturalism and Intergroup Relations. Washington, DC: American Psychological Association Press, 2008. Moghaddam, Fathali M., and James M...Technical Information Center Ft. Belvoir, Virginia 2. Dudley Knox Library Naval Postgraduate School Monterey, California 85

  8. Evading the Endgame in an Insurgency Undertaking: The Case of the Lord’s Resistance Army and Beyond

    Science.gov (United States)

    2015-06-01

    the argument, see Michelle Hale Williams, “Grappling with Ethnic Difference in Multicultural Societies,” in The Multicultural Dilemma: Migration...Michelle Hale. “Grappling with Ethnic Difference in Multicultural Societies.” In The Multicultural Dilemma: Migration, Ethnic Politics, and State...Center Ft. Belvoir, Virginia 2. Dudley Knox Library Naval Postgraduate School Monterey, California

  9. Polyamines mediate abnormal Ca2+ transport and Ca2+-induced cardiac cell injury in the calcium paradox

    International Nuclear Information System (INIS)

    Trout, J.J.; Koenig, H.; Goldstone, A.D.; Lu, C.Y.; Fan, C.C.

    1986-01-01

    Ca 2+ -free perfusion renders heart cells Ca 2+ -sensitive so that readmission of Ca 2+ causes a sudden massive cellular injury attributed to abnormal entry of Ca 2+ into cells (Ca paradox). Hormonal stimulation of Ca 2+ fluxes was earlier shown to be mediated by polyamines (PA). 5 min perfusion of rat heart with Ca 2+ -free medium induce a prompt 40-50% decline in levels of the PA putrescine (PUT), spermidine and spermine and their rate-regulatory synthetic enzyme ornithine decarboxylase (ODC), and readmission of Ca 2+ -containing medium abruptly ( 2+ reperfusion-induced increases in ODC and PA and also prevented increased 45 Ca 2+ uptake and heart injury, manifested by loss of contractility, release of enzymes (CPK, LDH), myoglobin and protein, and E.M. lesions (contracture bands, mitochondrial changes). 1 mM PUT negated DFMO inhibition, repleted heart PA and restored Ca 2+ reperfusion-induced 45 Ca 2+ influx and cell injury. These data indicate that the Ca 2+ -directed depletion-repletion cycle of ODC and PA triggers excessive transsarcolemmal Ca 2+ transport leading to the calcium paradox

  10. Intracellular alkalinization induces cytosolic Ca2+ increases by inhibiting sarco/endoplasmic reticulum Ca2+-ATPase (SERCA.

    Directory of Open Access Journals (Sweden)

    Sen Li

    Full Text Available Intracellular pH (pHi and Ca(2+ regulate essentially all aspects of cellular activities. Their inter-relationship has not been mechanistically explored. In this study, we used bases and acetic acid to manipulate the pHi. We found that transient pHi rise induced by both organic and inorganic bases, but not acidification induced by acid, produced elevation of cytosolic Ca(2+. The sources of the Ca(2+ increase are from the endoplasmic reticulum (ER Ca(2+ pools as well as from Ca(2+ influx. The store-mobilization component of the Ca(2+ increase induced by the pHi rise was not sensitive to antagonists for either IP(3-receptors or ryanodine receptors, but was due to inhibition of the sarco/endoplasmic reticulum Ca(2+-ATPase (SERCA, leading to depletion of the ER Ca(2+ store. We further showed that the physiological consequence of depletion of the ER Ca(2+ store by pHi rise is the activation of store-operated channels (SOCs of Orai1 and Stim1, leading to increased Ca(2+ influx. Taken together, our results indicate that intracellular alkalinization inhibits SERCA activity, similar to thapsigargin, thereby resulting in Ca(2+ leak from ER pools followed by Ca(2+ influx via SOCs.

  11. Edward C. Little Water Recycling Plant, El Segundo, CA: CA0063401

    Science.gov (United States)

    Joint EPA and Los Angeles Regional Water Quality Control Board NPDES Permit and Waiver from Secondary Treatment for the West Basin Municipal Water District Edward C. Little Water Recycling Plant, El Segundo, CA: CA0063401

  12. Large conductance Ca2+-activated K+ (BK channel: Activation by Ca2+ and voltage

    Directory of Open Access Journals (Sweden)

    RAMÓN LATORRE

    2006-01-01

    Full Text Available Large conductance Ca2+-activated K+ (BK channels belong to the S4 superfamily of K+ channels that include voltage-dependent K+ (Kv channels characterized by having six (S1-S6 transmembrane domains and a positively charged S4 domain. As Kv channels, BK channels contain a S4 domain, but they have an extra (S0 transmembrane domain that leads to an external NH2-terminus. The BK channel is activated by internal Ca2+, and using chimeric channels and mutagenesis, three distinct Ca2+-dependent regulatory mechanisms with different divalent cation selectivity have been identified in its large COOH-terminus. Two of these putative Ca2+-binding domains activate the BK channel when cytoplasmic Ca2+ reaches micromolar concentrations, and a low Ca2+ affinity mechanism may be involved in the physiological regulation by Mg2+. The presence in the BK channel of multiple Ca2+-binding sites explains the huge Ca2+ concentration range (0.1 μM-100 μM in which the divalent cation influences channel gating. BK channels are also voltage-dependent, and all the experimental evidence points toward the S4 domain as the domain in charge of sensing the voltage. Calcium can open BK channels when all the voltage sensors are in their resting configuration, and voltage is able to activate channels in the complete absence of Ca2+. Therefore, Ca2+ and voltage act independently to enhance channel opening, and this behavior can be explained using a two-tiered allosteric gating mechanism.

  13. Influence of ER leak on resting cytoplasmic Ca2+ and receptor-mediated Ca2+ signalling in human macrophage.

    Science.gov (United States)

    Layhadi, Janice A; Fountain, Samuel J

    2017-06-03

    Mechanisms controlling endoplasmic reticulum (ER) Ca 2+ homeostasis are important regulators of resting cytoplasmic Ca 2+ concentration ([Ca 2+ ] cyto ) and receptor-mediated Ca 2+ signalling. Here we investigate channels responsible for ER Ca 2+ leak in THP-1 macrophage and human primary macrophage. In the absence of extracellular Ca 2+ we employ ionomycin action at the plasma membrane to stimulate ER Ca 2+ leak. Under these conditions ionomycin elevates [Ca 2+ ] cyto revealing a Ca 2+ leak response which is abolished by thapsigargin. IP 3 receptors (Xestospongin C, 2-APB), ryanodine receptors (dantrolene), and translocon (anisomycin) inhibition facilitated ER Ca 2+ leak in model macrophage, with translocon inhibition also reducing resting [Ca 2+ ] cyto . In primary macrophage, translocon inhibition blocks Ca 2+ leak but does not influence resting [Ca 2+ ] cyto . We identify a role for translocon-mediated ER Ca 2+ leak in receptor-mediated Ca 2+ signalling in both model and primary human macrophage, whereby the Ca 2+ response to ADP (P2Y receptor agonist) is augmented following anisomycin treatment. In conclusion, we demonstrate a role of ER Ca 2+ leak via the translocon in controlling resting cytoplasmic Ca 2+ in model macrophage and receptor-mediated Ca 2+ signalling in model macrophage and primary macrophage. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Combined Evaluation of AFP, CA15-3, CA125, CA19-9, and CEA Tumor Markers in Patients with Hepatitis B and C.

    Science.gov (United States)

    Assmar, Mehdi; Yeganeh, Sara; Mansourghanaei, Fariborz; Amirmozafari, Nour

    2016-12-01

    This study aimed to determine the role of tumor markers AFP, CA15-3, CA125, CA19-9 and CEA in patients with hepatitis B and C. This descriptive cross-sectional study was performed from Oct 2012 to Oct 2014. Serum samples of 129 patients with hepatitis B and C referred to Guilan Liver and Digestive Disease Research Center in Rasht, Iran were collected and checked for the existence of the listed tumor markers by ELISA. No increase in serum levels of tumor marker CA19-9, CEA and CA15-3 were seen in patients with hepatitis ( P >0.05). In patients with hepatitis B, increase in CA125 were observed ( P =0.03). In hepatitis C patients, there was an increase in AFP levels ( P =0.03). The levels of AFP and CA125 markers were high in hepatitis C and hepatitis B, respectively. However, the increased levels were not seen is malignancy. Due to the small sample size, further study is necessary to find the reasons of the increase.

  15. Cognitive Depth and Hybrid Warfare: Exploring the Nature of Unique Time, Space, and Logic Frames

    Science.gov (United States)

    2017-05-25

    upon an earlier research monograph by William J. Nemeth at the Naval Post-Graduate School. In “Future War and Chechnya : A Case for Hybrid War,” Nemeth...8 William, Nemeth, Future War and Chechnya : A Case for Hybrid Warfare (Monterey: Naval Postgraduate School, June 2002) 2-3. 7...does.10 Yet, using Chechnya and the Chechnian Wars as an example of a hybrid society and hybrid wars, Nemeth’s view limits the concept in terms of

  16. Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.

    Directory of Open Access Journals (Sweden)

    Peter Rellos

    2010-07-01

    Full Text Available Long-term potentiation (LTP, a long-lasting enhancement in communication between neurons, is considered to be the major cellular mechanism underlying learning and memory. LTP triggers high-frequency calcium pulses that result in the activation of Calcium/Calmodulin (CaM-dependent kinase II (CaMKII. CaMKII acts as a molecular switch because it remains active for a long time after the return to basal calcium levels, which is a unique property required for CaMKII function. Here we describe the crystal structure of the human CaMKIIdelta/Ca2+/CaM complex, structures of all four human CaMKII catalytic domains in their autoinhibited states, as well as structures of human CaMKII oligomerization domains in their tetradecameric and physiological dodecameric states. All four autoinhibited human CaMKIIs were monomeric in the determined crystal structures but associated weakly in solution. In the CaMKIIdelta/Ca2+/CaM complex, the inhibitory region adopted an extended conformation and interacted with an adjacent catalytic domain positioning T287 into the active site of the interacting protomer. Comparisons with autoinhibited CaMKII structures showed that binding of calmodulin leads to the rearrangement of residues in the active site to a conformation suitable for ATP binding and to the closure of the binding groove for the autoinhibitory helix by helix alphaD. The structural data, together with biophysical interaction studies, reveals the mechanism of CaMKII activation by calmodulin and explains many of the unique regulatory properties of these two essential signaling molecules.This article can also be viewed as an enhanced version in which the text of the article is integrated with interactive 3-D representations and animated transitions. Please note that a web plugin is required to access this enhanced functionality. Instructions for the installation and use of the Web plugin are available in Text S1.

  17. Prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma

    Science.gov (United States)

    Wang, Wei; Chen, Xiao-Long; Zhao, Shen-Yu; Xu, Yu-Hui; Zhang, Wei-Han; Liu, Kai; Chen, Xin-Zu; Yang, Kun; Zhang, Bo; Chen, Zhi-Xin; Chen, Jia-Ping; Zhou, Zong-Guang; Hu, Jian-Kun

    2016-01-01

    The prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma (GC) has been widely reported and is still under debate. Here, we evaluated the prognostic significance of preoperative serum CA125, CA19-9 and CEA in patients with GC. 1692 patients with GC who underwent gastrectomy were divided into the training (from January 2005 to December 2011, n = 1024) and the validation (from January 2012 to December 2013, n = 668) cohorts. Positive groups of CA125 (> 13.72 U/ml), CA19-9 (> 23.36 U/ml) and CEA (> 4.28 ng/ml) were significantly associated with more advanced clinicopathological traits and worse outcomes than that of negative groups (all P tumor size (P tumor markers (NPTM) were more accurate in prognostic prediction than TNM stage alone. Our findings suggested that elevated preoperative serum CA125, CA19-9 and CEA were associated with more advanced clinicopathological traits and less favorable outcomes. In addition, CA125 as an independent prognostic factor should be further investigated. Nomogram based on NPTM could accurately predict the prognosis of GC patients. PMID:27097114

  18. Impact parameter determination for 40Ca + 40Ca reactions using a neural network

    International Nuclear Information System (INIS)

    Haddad, F.; Hagel, K.; Li, J.; Mdeiwayeh, N.; Natowitz, J.B.; Wada, R.; Xiao, B.; David, C.; Freslier, M.; Aichelin, J.

    1995-01-01

    A neural network is used for the impact parameter determination in 40 Ca + 40 Ca reactions at energies between 35 and 70 AMeV. A special attention is devoted to the effect of experimental constraints such as the detection efficiency. An overall improvement of the impact parameter determination of 25% is obtained with the neural network. The neural network technique is then used in the analysis of the Ca+Ca data at 35 AMeV and allows separation of three different class of events among the selected 'complete' events. (authors). 8 refs., 5 figs

  19. PGC-1α accelerates cytosolic Ca2+ clearance without disturbing Ca2+ homeostasis in cardiac myocytes

    International Nuclear Information System (INIS)

    Chen, Min; Wang, Yanru; Qu, Aijuan

    2010-01-01

    Energy metabolism and Ca 2+ handling serve critical roles in cardiac physiology and pathophysiology. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) is a multi-functional coactivator that is involved in the regulation of cardiac mitochondrial functional capacity and cellular energy metabolism. However, the regulation of PGC-1α in cardiac Ca 2+ signaling has not been fully elucidated. To address this issue, we combined confocal line-scan imaging with off-line imaging processing to characterize calcium signaling in cultured adult rat ventricular myocytes expressing PGC-1α via adenoviral transduction. Our data shows that overexpressing PGC-1α improved myocyte contractility without increasing the amplitude of Ca 2+ transients, suggesting that myofilament sensitivity to Ca 2+ increased. Interestingly, the decay kinetics of global Ca 2+ transients and Ca 2+ waves accelerated in PGC-1α-expressing cells, but the decay rate of caffeine-elicited Ca 2+ transients showed no significant change. This suggests that sarcoplasmic reticulum (SR) Ca 2+ -ATPase (SERCA2a), but not Na + /Ca 2+ exchange (NCX) contribute to PGC-1α-induced cytosolic Ca 2+ clearance. Furthermore, PGC-1α induced the expression of SERCA2a in cultured cardiac myocytes. Importantly, overexpressing PGC-1α did not disturb cardiac Ca 2+ homeostasis, because SR Ca 2+ load and the propensity for Ca 2+ waves remained unchanged. These data suggest that PGC-1α can ameliorate cardiac Ca 2+ cycling and improve cardiac work output in response to physiological stress. Unraveling the PGC-1α-calcium handing pathway sheds new light on the role of PGC-1α in the therapy of cardiac diseases.

  20. Initial Application of the FEMP Measurement and Verification Guidelines in Super ESPC Delivery Orders: Final Report; May 2000

    Energy Technology Data Exchange (ETDEWEB)

    Jump, D.; Stetz, M.

    2000-09-05

    Schiller Associates examined the measurement and verification (M and V) plans and activities for seven Western Region Super Energy Savings Performance Contract (ESPC) projects to learn how federal agencies are implementing M and V and what factors influence M and V plan development. This report describes the method used to examine the M and V plans and presents the findings. The goals were to find common factors that influenced M and V plan development and implementation, assess risks to the agency as a result of particular M and V plans, and develop recommendations for improving M and V plan development and implementation. Participating agencies and sites were: (1) National Park Service, Yosemite National Park, CA; (2) Veterans Affairs, VA Medical Center, San Francisco, CA; (3) US Forest Service, USFS Laboratory, Corvallis, OR; (4) Federal Aviation Administration, ATRCC, Auburn, WA; (5) US Department of Defense, Defense Manpower Data Center, Monterey, CA; (6) US Coast Guard, Coast Guard Station, Alameda, CA; and (7) US Navy, Pt. Mugu, Oxnard, CA.

  1. Comparison of phosgene, chlorine, and hydrogen chloride as reagents for converting molten CaO.CaCl2 to CaCl2

    International Nuclear Information System (INIS)

    Fife, K.W.

    1985-01-01

    One method at Los Alamos for preparing impure plutonium metal from the impure oxide is by batch reduction with calcium metal at 850 0 C in a CaCl 2 solvent. The solvent salt from this reduction is currently discarded as low-level radioactivity waste only because it is saturated with the CaO byproduct. We have demonstrated a pyrochemical technique for converting the CaO to CaCl 2 thereby incorporating solvent recycling into the batch reduction process. We will discuss the effectiveness of HCl, Cl 2 , and COCl 2 as chlorinating agents and recycling actual spent process solvent salts. 6 refs., 8 figs

  2. The center-to-limb behavior of CaI lambda 6573 and [Ca II] lambda 7324

    International Nuclear Information System (INIS)

    Ayres, T.R.; Testerman, L.

    1978-01-01

    Center-to-limb measurements of the Ca I lambda 6573 intercombination line and the Ca II lambda 7324 forbidden line are compared with synthetic profiles based on a simple representation of the non-LTE Ca-Ca + ionization equilibrium. The effects of photoionization from low lying excited states of neutral calcium are found to reduce the sensitivity of the lambda 6573 center-to-limb behavior as a thermal structure diagnostic. The synthetic center-to-limb behavior is also sensitive to uncertainties in the nonthermal broadening. Nevertheless, the measured center-to-limb behavior of lambda 6573 favors a 'cool' photospheric model similar to the Vernazza, Avrett, and Loeser model M over hotter models based on the Ca II K wings. The non-LTE calcium abundance obtained from the disk center equivalent widths of lambda 6573 and lambda 7324 using the best fit model is Asub(Ca)approximately=2.1+-0.2x10 -6 (by number relative to hydrogen). Applications of these lines as diagnostics of the Ca-Ca + ionization equilibrium in other stars are briefly discussed. (Auth.)

  3. Operational Contract Support: Economic Impact Evaluation and Measures of Effectiveness

    Science.gov (United States)

    2017-12-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT OPERATIONAL CONTRACT SUPPORT: ECONOMIC IMPACT EVALUATION AND MEASURES...DATES COVERED MBA professional report 4. TITLE AND SUBTITLE OPERATIONAL CONTRACT SUPPORT: ECONOMIC IMPACT EVALUATION AND MEASURES OF EFFECTIVENESS 5...evaluation, expeditionary economics , operational contract support, measure of effectiveness 15. NUMBER OF PAGES 89 16. PRICE CODE 17. SECURITY

  4. Economic Security Environment and Implementation of Planning, Programming, Budgeting, Execution (PPBE) System in Georgia

    Science.gov (United States)

    2004-06-01

    Roy J. What Determines Economic Growth? Economic Review – Second Quarter 1993 [References: Barro (1991); Mankiw , Romer, and Well (1992); De Long...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release: distribution unlimited ECONOMIC SECURITY...DATES COVERED Master’s Thesis 4. TITLE AND SUBTITLE: Economic Security Environment and Implementation of Planning, Programming, Budgeting, Execution

  5. Analysis Of Navy Hornet Squadron Mishap Costs With Regard To Previously Flown Flight Hours

    Science.gov (United States)

    2017-06-01

    Psychological Association ( APA ) manual guidelines for reporting statistics have recommended reporting exact p-values, and avoiding arbitrary...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. ANALYSIS OF NAVY...Advisor Kenneth Doerr THIS PAGE INTENTIONALLY LEFT BLANK i REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 Public reporting burden

  6. Astronaut training ground

    OpenAIRE

    2000-01-01

    "While most NPS graduates are still assigned to sea missions, so many are venturing into the "Final Frontier" that NPS is among the top four schools in producing future astronauts. Since moving to Monterey from the Naval Academy in 1951, NPS has already graduated 35 astronauts, some of whom have flown Space Shuttle missions..."

  7. Federal Aviation Administration Curriculum Guide for Aviation Magnet Schools Programs

    Science.gov (United States)

    1994-01-01

    Prepared ca. 1994. This publication is designed to provide: : - a brief history of the role of aviation in motivating young : people to learn. : - examples of aviation magnet activities, programs, projects and : school curriculums. : - documentation ...

  8. Nanosilica supported CaO: A regenerable and mechanically hard CO2 sorbent at Ca-looping conditions

    International Nuclear Information System (INIS)

    Sanchez-Jimenez, P.E.; Perez-Maqueda, L.A.; Valverde, J.M.

    2014-01-01

    Highlights: • A synthetic CO 2 sorbent is prepared by impregnation of calcium nitrate on a nanosilica matrix. • Sintering of the nascent CaO in the calcination stage of carbonation/calcination cycles is hindered. • CaO conversion reaches a stable value well above the residual conversion of natural limestone. • Particle fragmentation as caused by ultrasonic irradiation in a liquid dispersion is hindered. - Abstract: This work presents a CO 2 sorbent that may be synthesized from low-cost and widely available materials following a simple method basically consisting of impregnation of a nanostructured silica support with a saturated solution of calcium nitrate. In a first impregnation stage, the use of a stoichiometric CaO/SiO 2 ratio serves to produce a calcium silicate matrix after calcination. This calcium silicate matrix acts as a thermally stable and mechanically hard support for CaO deposited on it by further impregnation. The CaO-impregnated sorbent exhibits a stable CaO conversion at Ca-looping conditions whose value depends on the CaO wt% deposited on the calcium silicate matrix, which can be increased by successive reimpregnations. A 10 wt% CaO impregnated sorbent reaches a stable conversion above 0.6 whereas the stable conversion of a 30 wt% CaO impregnated sorbent is around 0.3, which is much larger than the residual conversion of CaO derived from natural limestone (between 0.07 and 0.08). Moreover, particle size distribution measurements of samples predispersed in a liquid and subjected to high energy ultrasonic waves indicate that the CaO-impregnated sorbent has a relatively high mechanical strength as compared to limestone derived CaO

  9. Knowledge and Attitude of Public Secondary School Teachers ...

    African Journals Online (AJOL)

    The study investigated knowledge and attitude of public secondary school teachers towards continuous assessment (CA) practices in Edo Central Senatorial District, Nigeria. The study was undertaken to determine the influence of gender, age, years of experience and area of educational specialization on teachers' attitude ...

  10. Thermoluminescence of CaCO3:Dy and CaCO3:Mn

    International Nuclear Information System (INIS)

    Bapat, V.N.; Nambi, K.S.V.

    1976-01-01

    CaCO 3 samples doped with Dy and Mn were prepared in the laboratory by co-precipitation techniques. Thermoluminescence and emission spectra of these phosphors were studied and were compared with those of the naturally occuring calcite and undoped CaCO 3 samples. Dy-doping seems to give a more efficient phosphor and indicates a possibility of getting a better phosphor by a judicious choice of a rare earth doping of CaCO 3 . Interesting result have been obtained on the TL glow curve variations of these phosphors with different temperature treatments prior to irradiation. (author)

  11. Chemical purification of CaCO{sub 3} and CaWO{sub 4} powders used for CaWO{sub 4} crystal production for the CRESST experiment

    Energy Technology Data Exchange (ETDEWEB)

    Trinh Thi, H.H.; Defay, X.; Erb, A.; Hampf, R.; Lanfranchi, J.C.; Langenkaemper, A.; Morgalyuk, V.; Muenster, A.; Mondragon, E.; Oppenheimer, C.; Potzel, W.; Schoenert, S.; Steiger, H.; Ulrich, A.; Wawoczny, S.; Willers, M.; Zoeller, A. [Physik-Department and Excellence Cluster Universe, Technische Universitaet Muenchen, Garching (Germany)

    2016-07-01

    CRESST (Cryogenic Rare Event Search with Superconducting Thermometers) uses CaWO{sub 4} single crystals as targets for the direct search for dark matter particles. Since several years these CaWO{sub 4} crystals are grown at the Technische Universitaet Muenchen. Thereby, commercially available CaCO{sub 3} and WO{sub 3} powders are used for the synthesis of CaWO{sub 4} powder. For the experiment low intrinsic contaminations of the crystals play a crucial role. In order to improve the radiopurity of the crystals it is necessary to reduce potential sources for radioactive backgrounds such as U and Th. In this poster we will present our studies of the chemical purification of the CaCO{sub 3} and CaWO{sub 4} powders.

  12. Ischemic damage in hippocampal CA1 is dependent on glutamate release and intact innervation from CA3

    DEFF Research Database (Denmark)

    Benveniste, H; Jørgensen, M B; Sandberg, M

    1989-01-01

    The removal of glutamatergic afferents to CA1 by destruction of the CA3 region is known to protect CA1 pyramidal cells against 10 min of transient global ischemia. To investigate further the pathogenetic significance of glutamate, we measured the release of glutamate in intact and CA3-lesioned CA...

  13. Up-regulation of Ca2+/CaMKII/CREB signaling in salicylate-induced tinnitus in rats.

    Science.gov (United States)

    Zhao, Jiuhan; Wang, Biao; Wang, Xiaohong; Shang, Xiuli

    2018-02-09

    The purpose of the study was to investigate the changes of Ca 2+ /calmodulin-dependent protein kinases II (CaMKII)/cAMP response element-binding protein (CREB) signaling pathway in a rat tinnitus model. Eighteen Wistar rats were randomly divided into three groups: normal control (NC), normal saline (NS), and tinnitus model (TM) groups. Tinnitus model was induced by intraperitoneal injection of salicylate. The concentration of intracellular calcium level in auditory cortex cells was determined using Fura-2 acetoxymethyl ester (Fura-2 AM) method with fluorospectrophotometer. Expressions of calmodulin (CaM), N-methyl-D-aspartate receptor 2B subunit (NR2B), calcium-calmodulin kinase II (CaMKII), and cAMP response element-binding protein (CREB) were detected with Western blot. Tinnitus model was successfully established by the intraperitoneal administration of salicylate in rats. Compared with rats in NC and NS groups, salicylate administration significantly elevated CaM, NR2B, phospho-CaMKII and phospho-CREB expression in auditory cortex from tinnitus model group (p salicylate administration causes tinnitus symptoms and elevates Ca 2+ /CaMKII/CREB signaling pathway in auditory cortex cells. Our study likely provides a new understanding of the development of tinnitus.

  14. Ca isotopic fractionation patterns in forest ecosystems

    Science.gov (United States)

    Kurtz, A. C.; Takagi, K.

    2012-12-01

    Calcium stable isotope ratios are an emerging tracer of the biogeochemical cycle of Ca that are just beginning to see significant application to forest ecosystems. The primary source of isotopic fractionation in these systems is discrimination against light Ca during uptake by plant roots. Cycling of vegetation-fractionated Ca establishes isotopically distinct Ca pools within a forest ecosystem. In some systems, the shallow soil exchangeable Ca pool is isotopically heavy relative to Ca inputs. This has been explained by preferential removal of light Ca from the soil. In other systems, the soil exchange pool is isotopically light relative to inputs, which is explained by recycling of plant-fractionated light Ca back into soil. Thus vegetation uptake of light Ca has been called on to account for both isotopically heavy and light Ca in the shallow soil exchange pools. We interpret patterns in ecosystem δ44Ca with the aid of a simple box model of the forest Ca cycle. We suggest that the δ44Ca of exchangeable Ca in the shallow soil pool primarily reflects the relative magnitude of three key fluxes in a forest Ca cycle, 1) the flux of external Ca into the system via weathering or atmospheric deposition, 2) the uptake flux of Ca from soils into the vegetation pool, and 3) the return flux of Ca to shallow soils via remineralization of leaf litter. Two observations that emerge from our model may aid in the application of Ca isotopes to provide insight into the forest Ca cycle. First, regardless of the magnitude of both vegetation Ca uptake and isotopic fractionation, the δ44Ca of the soil exchange pool will equal the input δ44Ca unless the plant uptake and remineralization fluxes are out of balance. A second observation is that the degree to which the shallow soil exchange pool δ44Ca can differ from the input ratio is controlled by the relative rates of biological uptake and external Ca input. Significant differences between soil exchange and input δ44Ca are seen only

  15. Spin decomposition of the responses of 44Ca and 48Ca to 300 MeV protons

    International Nuclear Information System (INIS)

    Baker, F.T.; Bimbot, L.; Fergerson, R.W.; Glashausser, C.; Green, A.; Haeusser, O.; Hicks, K.; Jones, K.; Miller, C.A.; Vetterli, M.; Abegg, R.; Beatty, D.; Bonin, B.; Castel, B.; Chen, X.Y.; Cupps, V.; Djalali, C.; Henderson, R.; Jackson, K.P.; Jeppesen, R.; Nakayama, K.; Nanda, S.K.; Sawafta, R.; Yen, S.; Institut de Physique Nucleaire, F-91406 Orsay, France; Rutgers University, Piscataway, New Jersey 08854; Simon Fraser University, Burnaby, Canada V5A1S6; TRIUMF, 4004 Westbrook Mall, Vancouver, Canada V6T2A3; Los Alamos National Laboratory, Los Alamos, New Mexico 87544; Centre d'Etudes Nucleaires de Saclay, 91191 Gif sur Yvette, CEDEX, France; Queen's University, Kingston, Canada K7L3N6; University of Colorado, Boulder, Colorado 80309; University of South Carolina, Columbia, South Carolina 29208; Continuous Electron Beam Accelerator Facility, 12000 Jefferson Ave., Newport News, Virginia 23606; University of Alberta, Edmonton, Canada T6G2J1)

    1991-01-01

    Angular distributions of the double-differential cross section d 2 σ/dΩ dE(σ) and the spin-flip probability S nn have been measured for inclusive proton inelastic scattering from 44 Ca at 290 MeV and from 48 Ca at 318 MeV. Excitation energies up to about 50 MeV for 44 Ca and 40 MeV for 48 Ca have been investigated over the laboratory angular ranges of 3 degree to 12 degree for 44 Ca and 3 degree to 9 degree for 48 Ca. Multipole decompositions of angular distributions of both the spin-flip cross section σS nn and the estimated cross section for ΔS=0 transitions have been performed. Distributions of strengths were deduced for ΔL=1, ΔS=0 (the giant dipole), ΔL=2, ΔS=0 (the giant quadrupole), ΔL=0, ΔS=1 (the magnetic dipole), ΔL=1, ΔS=1 (the spin dipole), and ΔL=2, ΔS=1 (the spin quadrupole). The ΔS=0 summed strengths for 44 Ca are lower than for 40 Ca and 48 Ca. The spin-dipole summed strengths are found to be approximately independent of A. For 48 Ca, essentially all M1 strength observed was in the 10.23 MeV 1 + state; for 44 Ca, M1 strength was observed to be fragmented over a range of 7 to 18 Mev

  16. Unconventional Restraint: Obstacles to Army Special Operations Forces Employment in Support to Resistance Operations

    Science.gov (United States)

    2017-12-01

    means of international competition through lessons learned in multiple conflicts. The motivation for a change in tactics and strategy in war...century, when changes in international laws and norms began promoting the concepts of state sovereignty and self- determination, causing states to...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. UNCONVENTIONAL

  17. Improved airfield damage assessment System (IADAS) capstone

    Science.gov (United States)

    2017-09-01

    that the Air Force Civil Engineer career field is prepared for the future of expeditionary warfare by integrating the latest technology into TTPs...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA SYSTEMS ENGINEERING CAPSTONE PROJECT REPORT Approved for public release...alternatives for improving the timeliness of airfield damage assessment. The systems engineering methods used included a morphological box and Pugh matrix

  18. Engineering Resilience Into The Marine Expeditionary Units Resupply System Through Military Foraging

    Science.gov (United States)

    2017-09-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. ENGINEERING ...ONLY (Leave blank) 2. REPORT DATE September 2017 3. REPORT TYPE AND DATES COVERED Master’s Thesis 4. TITLE AND SUBTITLE ENGINEERING RESILIENCE...to the resilience of the MEU platoons and squads. 14. SUBJECT TERMS systems engineering , modeling, foraging, energy, water, resupply, ExtendSim

  19. Investigation of Requirements and Capabilities of Next Generation Mine Warfare Unmanned Underwater Vehicles

    Science.gov (United States)

    2017-12-01

    horn” contacts something hard, which bends it, activating a chemical reaction to set off the explosive (NAP 2000). • Influence activation is the most...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA SYSTEMS ENGINEERING CAPSTONE PROJECT REPORT Approved for public release...performance. Model-based systems engineering (MBSE) tools, including functional flow block diagrams and functional hierarchies, are used to

  20. Indian, Japanese, And U.S. Responses To Chinese Submarine Modernization

    Science.gov (United States)

    2016-03-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited INDIAN, JAPANESE ...DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE INDIAN, JAPANESE , AND U.S. RESPONSES TO CHINESE SUBMARINE MODERNIZATION 5. FUNDING NUMBERS 6...is unlimited INDIAN, JAPANESE , AND U.S. RESPONSES TO CHINESE SUBMARINE MODERNIZATION David E. Kiser Lieutenant Commander, United States

  1. The Role of Mental Illness Identification and Screening in Firearm Background Checks

    Science.gov (United States)

    2017-12-01

    need to change to account for these treatment models. Public and governmental leaders need to understand factors impacting the relationship between...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. THE ROLE OF...Second Reader: Michael Biasotti THIS PAGE INTENTIONALLY LEFT BLANK i REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 Public reporting

  2. Examining Changing American Perceptions of the Terrorist Threat: From the Oklahoma City Bombing to Al Qaeda

    Science.gov (United States)

    2017-12-01

    information. As a result, accountability measures, such as oversight by Congress or public debate by watchdog groups like the media are difficult to...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. EXAMINING... Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instruction

  3. Nations at Risk-- Indicators of Fragility in States Susceptible to Terrorist Attacks

    Science.gov (United States)

    2018-03-01

    influenced by reasonable cost - benefit considerations. Moreover, the authors conclude that terrorism is "predominantly rooted in unfavorable...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. NATIONS AT RISK...Advisor Ryan Garcia THIS PAGE INTENTIONALLY LEFT BLANK i REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704–0188 Public reporting burden for

  4. Swiss Strategic Communication in the Defense Sector and Its Implications for Swiss Security Policy

    Science.gov (United States)

    2017-12-01

    rejected because of its projected higher costs compared to buying the fighter jets.392 Through a public -private partnership, the needed Gripens would...necessary military strategies, overall efficiency and coherence can be augmented to the benefit of national security, the public finances, and the...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. SWISS STRATEGIC

  5. Economic Value of Army Foreign Military Sales

    Science.gov (United States)

    2015-12-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT ECONOMIC VALUE OF ARMY FOREIGN MILITARY SALES ...this collection of information is estimated to average 1 hour per response, including the time for reviewing instruction, searching existing data...sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden

  6. An Improved Inventory Control Model for the Brazilian Navy Supply System

    Science.gov (United States)

    2001-12-01

    Portuguese Centro de Controle de Inventario da Marinha, the Brazilian Navy Inventory Control Point (ICP) developed an empirical model called SPAADA...NAVAL POSTGRADUATE SCHOOL Monterey, California THESIS Approved for public release; distribution is unlimited AN IMPROVED INVENTORY CONTROL ...AN IMPROVED INVENTORY CONTROL MODEL FOR THE BRAZILIAN NAVY SUPPLY SYSTEM Contract Number Grant Number Program Element Number Author(s) Moreira

  7. How Should Public Administration Education Curriculum Within Indiana Higher Education Institutions Evolve to Reflect the Complex Homeland Security Issues Faced by Future Public Sector Employees?

    Science.gov (United States)

    2012-03-01

    Administration Research and Theory, 25–57. O’Leary, R. (2010). Traditions, ideas, spirits, event, challenge. Journal of Public Adminstration , 1–36. Purdue...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited HOW SHOULD PUBLIC ... PUBLIC SECTOR EMPLOYEES? by Bryant S. Lucas March 2012 Thesis Advisor: Christopher Bellavita Second Reader: Lauren Wollman THIS PAGE

  8. Hydrodynamic Forces on Composite Structures

    Science.gov (United States)

    2014-06-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited HYDRODYNAMIC ...Thesis 4. TITLE AND SUBTITLE HYDRODYNAMIC FORCES ON COMPOSITE STRUCTURES 5. FUNDING NUMBERS 6. AUTHOR(S) Scott C. Millhouse 7. PERFORMING...angles yields different free surface effects including vortices and the onset of cavitation . 14. SUBJECT TERMS Fluid structure interaction, FSI, finite

  9. Public Budgeting: The Compromises Among the Sound Budgeting Principles in Contingency Funding

    Science.gov (United States)

    2017-06-01

    funding for major aircraft using supplemental appropriations in place of incremental funding as intended for normal budgeting practices. This was a prime... incrementally funded on an annual basis. This change in budgeting practices lacked predictability because it allowed last-minute budget requests with low...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. PUBLIC BUDGETING

  10. Social Media Integration into State-Operated Fusion Centers and Local Law Enforcement: Potential Uses and Challenges

    Science.gov (United States)

    2010-12-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited SOCIAL MEDIA...DATE December 2010 3. REPORT TYPE AND DATES COVERED Master’s Thesis 4. TITLE AND SUBTITLE Social Media Integration into State-Operated Fusion...technologies, particularly social media, within fusion centers and local law enforcement entities could enable a more expedient exchange of information among

  11. Motivating Language and Empathic Leadership Drives Aircraft Readiness

    Science.gov (United States)

    2017-03-01

    M.O.T.O), which has helped me understand the impact of motivating language! Commanders and senior enlisted leaders, thank you for your shared...Exchange and Motivating Language. Source: Mayfield & Mayfield (2009). 3. Empathic Leadership in the Workplace Empathy or empathic emotions has an...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. MOTIVATING

  12. Reflecting on 20+ Years of “Executive Program in Defense Decision Making” Curriculum

    OpenAIRE

    2017-01-01

    CCMR News Article CCMR hosted a version of its biannual “Executive Program in Defense Decision Making” offering for 21 international military and civilian participants, from November 6-17, 2017. Often described as CCMR’s “flagship” course, this curriculum has been offered at the Naval Postgraduate School (NPS) in Monterey, California for over 20 years.

  13. Microwave Photonic Architecture for Direction Finding of LPI Emitters: Front End Analog Circuit Design and Component Characterization

    Science.gov (United States)

    2016-09-01

    into two parts. The design, development, and testing efforts of the front-end microwave photonics circuit design and the system integration with the...miniature microwave - photonic phase-sampling DF technique is investigated in this thesis. This front-end design uses a combination of integrated optical...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. MICROWAVE

  14. Russia’s Security Relations with Finland, Norway, and Sweden

    Science.gov (United States)

    2017-09-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. RUSSIA’S SECURITY... RELATIONS WITH FINLAND, NORWAY, AND SWEDEN by Rory J. Hayden September 2017 Thesis Advisor: Mikhail Tsypkin Co-Advisor: David S. Yost...THIS PAGE INTENTIONALLY LEFT BLANK i REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 Public reporting burden for this collection of

  15. Preventing Stress Disorders for Law Enforcement Officers Exposed to Disturbing Media

    Science.gov (United States)

    2016-09-01

    weaponry began to manifest similar symptoms. In 1952, the American Psychiatric Association ( APA ) produced the first Diagnostic and Statistical Manual ...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. PREVENTING STRESS...Halladay John Rollins THIS PAGE INTENTIONALLY LEFT BLANK i REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 Public reporting burden

  16. Suicide Terrorism in America?: The Complex Social Conditions of This Phenomenon and the Implications for Homeland Security

    Science.gov (United States)

    2014-11-05

    including suggestions for reducing this burden, to Washington headquarters Services, Directorate for Information Operations and Reports, 1215...necessary. Bloom writes that this support can come in several forms: Food, safe houses, recruits, financial support for weapons, remuneration of families...Virginia 2. Dudley Knox Library Naval Postgraduate School Monterey, California 3. Mark Sullivan, Director United States Secret Service Washington, DC

  17. An Analysis of AH-1Z Helicopter Pilots and Qualifications: The Impact of Fleet Squadron Training Progression Timelines

    Science.gov (United States)

    2018-03-01

    Time -in-Qualification Summary Statistics Box and Whisker Graph. .......54 Figure 10. Qualification Distribution and Comparison for PQM, ANSQ, and...the distribution curves; therefore, we must also consider the median for comparing time - to-train. Figure 10. Qualification Distribution and...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. AN ANALYSIS OF AH

  18. An Evolving Asymmetric Game for Modeling Interdictor-Smuggler Problems

    Science.gov (United States)

    2016-06-01

    ASYMMETRIC GAME FOR MODELING INTERDICTOR-SMUGGLER PROBLEMS by Richard J. Allain June 2016 Thesis Advisor: David L. Alderson Second Reader: W...DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE AN EVOLVING ASYMMETRIC GAME FOR MODELING INTERDICTOR- SMUGGLER PROBLEMS 5. FUNDING NUMBERS 6...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited AN EVOLVING

  19. Implementation of Policies to Bridge the Gap Between Police Officer Line of Duty Deaths and Agency Resiliency

    Science.gov (United States)

    2015-12-01

    cameras, tactical mirrors, and external vest carriers. The department also obtained an armored rescue vehicle, modern ballistic shields, and infrared...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited IMPLEMENTATION OF...DATE December 2015 3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE IMPLEMENTATION OF POLICIES TO BRIDGE THE GAP BETWEEN

  20. Tumor markers CA19-9, CA242 and CEA in the diagnosis of pancreatic cancer: a meta-analysis.

    Science.gov (United States)

    Zhang, Yimin; Yang, Jun; Li, Hongjuan; Wu, Yihua; Zhang, Honghe; Chen, Wenhu

    2015-01-01

    Pancreatic cancer has the worst prognosis and early detection is crucial for improving patient prognosis. Therefore, we performed a meta-analysis to evaluate and compare the sensitivity and specificity of single test of CA19-9, CA242, and CEA, as well as combination test in pancreatic cancer detection. We searched PubMed, Embase, Medline, and Wanfang databases for studies that evaluated the diagnostic validity of CA19-9, CA242, and CEA between January 1990 and September 2014. Data were analyzed by Meta-Disc and STATA software. A total of 21 studies including 3497 participants, which fulfilled the inclusion criteria were considered for analysis. The pooled sensitivities for CA19-9, CA242, and CEA were 75.4 (95% CI: 73.4-77.4), 67.8 (95% CI: 65.5-70), and 39.5 (95% CI: 37.3-41.7), respectively. The pooled specificities of CA19-9, CA242, and CEA were 77.6 (95% CI: 75.4-79.7), 83 (95% CI: 81-85), and 81.3 (95% CI: 79.3-83.2), respectively. Parallel combination of CA19-9+CA242 has a higher sensitivity (89, 95% CI: 80-95) without impairing the specificity (75, 95% CI: 67-82). Our meta-analysis showed that CA242 and CA19-9 have better performance in the diagnosis of pancreatic cancer than CEA. Furthermore, parallel combination test of CA19-9+CA242 could be of better diagnostic value than individual CA242 or CA19-9 test.

  1. Ab-initio calculations of the Ruddlesden-Popper phases CaMnO3, CaO(CaMnO3) and CaO(CaMnO3)2

    International Nuclear Information System (INIS)

    Cardoso, C; Borges, R P; Gasche, T; Godinho, M

    2008-01-01

    The present work reports ab-initio density functional theory calculations for the Ruddlesden-Popper phase CaO(CaMnO 3 ) n compounds. In order to study the evolution of the properties with the number of perovskite layers, a detailed analysis of the densities of states calculated for each compound and for several magnetic configurations was performed. The effect of distortions of the crystal structure on the magnetic ground state is also analysed and the exchange constants and transition temperatures are calculated for the three compounds using a mean field model. The calculated magnetic ground state structures and magnetic moments are in good agreement with experimental results and previous calculations

  2. Quantifying Ca2+ release and inactivation of Ca2+ release in fast- and slow-twitch muscles.

    Science.gov (United States)

    Barclay, C J

    2012-12-01

    The aims of this study were to quantify the Ca(2+) release underlying twitch contractions of mammalian fast- and slow-twitch muscle and to comprehensively describe the transient inactivation of Ca(2+) release following a stimulus. Experiments were performed using bundles of fibres from mouse extensor digitorum longus (EDL) and soleus muscles. Ca(2+) release was quantified from the amount of ATP used to remove Ca(2+) from the myoplasm following stimulation. ATP turnover by crossbridges was blocked pharmacologically (N-benzyl-p-toluenesulphonamide for EDL, blebbistatin for soleus) and muscle heat production was used as an index of Ca(2+) pump ATP turnover. At 20°C, Ca(2+) release in response to a single stimulus was 34 and 84 μmol (kg muscle)(-1) for soleus and EDL, respectively, and increased with temperature (30°C: soleus, 61 μmol kg(-1); EDL, 168 μmol kg(-1)). Delivery of another stimulus within 100 ms of the first produced a smaller Ca(2+) release. The maximum magnitude of the decrease in Ca(2+) release was greater in EDL than soleus. Ca(2+) release recovered with an exponential time course which was faster in EDL (mean time constant at 20°C, 32.1 ms) than soleus (65.6 ms) and faster at 30°C than at 20°C. The amounts of Ca(2+) released and crossbridge cycles performed are consistent with a scheme in which Ca(2+) binding to troponin-C allowed an average of ∼1.7 crossbridge cycles in the two muscles.

  3. Measurements of natural 41Ca concentrations

    International Nuclear Information System (INIS)

    Steinhof, A.

    1989-05-01

    Atomic mass spectroscopic examinations on 41 Ca were carried out in the UNILAC accelerator. A sensitivity of about 10 -15 was achieved. This would allow the measurement of present natural 41 Ca concentrations as soon as the problem of the transmission determination is solved. In this respect suggestions were worked out and their feasibility discussed. The detection of 41 Ca-ions is especially free of background when high UNILAC-energies are applied. An estimation showed a background level corresponding with a 41 Ca concentration of less then 10 -17 referred to 40 Ca. Besides an independent concept for the electromagnetic concentration of 41 Ca with variable concentration factors was developed. After being concentrated up to 50 respectively 25 times the initial concentration in the GSI mass separator, the 41 Ca concentration of three recent deer bones found in the Odenwald was measured by atomic mass spectroscopy in the 14UD-Pelletron Tandem in Rehovot (Israel). The measured 41 Ca concentrations ranged between 10 -14 to 10 -13 with consideration of the concentration factor. A theoretical study of the 41 Ca production in the earth's surface based on cosmic radiation illustrates the influence of trace elements on the neutron flux and thus on the 41 Ca production. This influence might be a possible explanation for the observed amplitude of variation of the 41 Ca concentration in recent bones which are of decisive importance for the feasibility of 41 Ca-related dating. In this work a method is suggested that does not depend on the amplitude of variation mentioned above and which would allow the determination of the erosion rate of rocks by its 41 Ca concentrations. (orig./HP) [de

  4. Bax regulates neuronal Ca2+ homeostasis.

    Science.gov (United States)

    D'Orsi, Beatrice; Kilbride, Seán M; Chen, Gang; Perez Alvarez, Sergio; Bonner, Helena P; Pfeiffer, Shona; Plesnila, Nikolaus; Engel, Tobias; Henshall, David C; Düssmann, Heiko; Prehn, Jochen H M

    2015-01-28

    Excessive Ca(2+) entry during glutamate receptor overactivation ("excitotoxicity") induces acute or delayed neuronal death. We report here that deficiency in bax exerted broad neuroprotection against excitotoxic injury and oxygen/glucose deprivation in mouse neocortical neuron cultures and reduced infarct size, necrotic injury, and cerebral edema formation after middle cerebral artery occlusion in mice. Neuronal Ca(2+) and mitochondrial membrane potential (Δψm) analysis during excitotoxic injury revealed that bax-deficient neurons showed significantly reduced Ca(2+) transients during the NMDA excitation period and did not exhibit the deregulation of Δψm that was observed in their wild-type (WT) counterparts. Reintroduction of bax or a bax mutant incapable of proapoptotic oligomerization equally restored neuronal Ca(2+) dynamics during NMDA excitation, suggesting that Bax controlled Ca(2+) signaling independently of its role in apoptosis execution. Quantitative confocal imaging of intracellular ATP or mitochondrial Ca(2+) levels using FRET-based sensors indicated that the effects of bax deficiency on Ca(2+) handling were not due to enhanced cellular bioenergetics or increased Ca(2+) uptake into mitochondria. We also observed that mitochondria isolated from WT or bax-deficient cells similarly underwent Ca(2+)-induced permeability transition. However, when Ca(2+) uptake into the sarco/endoplasmic reticulum was blocked with the Ca(2+)-ATPase inhibitor thapsigargin, bax-deficient neurons showed strongly elevated cytosolic Ca(2+) levels during NMDA excitation, suggesting that the ability of Bax to support dynamic ER Ca(2+) handling is critical for cell death signaling during periods of neuronal overexcitation. Copyright © 2015 the authors 0270-6474/15/351706-17$15.00/0.

  5. Structural basis for the differential effects of CaBP1 and calmodulin on CaV1.2 calcium-dependent inactivation

    Science.gov (United States)

    Findeisen, Felix; Minor, Daniel L.

    2010-01-01

    Calcium-binding protein 1 (CaBP1), a calmodulin (CaM) homolog, endows certain voltage-gated calcium channels (CaVs) with unusual properties. CaBP1 inhibits CaV1.2 calcium-dependent inactivation (CDI) and introduces calcium-dependent facilitation (CDF). Here, we show that the ability of CaBP1 to inhibit CaV1.2 CDI and induce CDF arises from interaction between the CaBP1 N-lobe and interlobe linker residue Glu94. Unlike CaM, where functional EF hands are essential for channel modulation, CDI inhibition does not require functional CaBP1 EF-hands. Furthermore, CaBP1-mediated CDF has different molecular requirements than CaM-mediated CDF. Overall, the data show that CaBP1 comprises two structural modules having separate functions: similar to CaM, the CaBP1 C-lobe serves as a high-affinity anchor that binds the CaV1.2 IQ domain at a site that overlaps with the Ca2+/CaM C-lobe site, whereas the N-lobe/linker module houses the elements required for channel modulation. Discovery of this division provides the framework for understanding how CaBP1 regulates CaVs. PMID:21134641

  6. Structural basis for the differential effects of CaBP1 and calmodulin on Ca(V)1.2 calcium-dependent inactivation.

    Science.gov (United States)

    Findeisen, Felix; Minor, Daniel L

    2010-12-08

    Calcium-binding protein 1 (CaBP1), a calmodulin (CaM) homolog, endows certain voltage-gated calcium channels (Ca(V)s) with unusual properties. CaBP1 inhibits Ca(V)1.2 calcium-dependent inactivation (CDI) and introduces calcium-dependent facilitation (CDF). Here, we show that the ability of CaBP1 to inhibit Ca(V)1.2 CDI and induce CDF arises from interaction between the CaBP1 N-lobe and interlobe linker residue Glu94. Unlike CaM, where functional EF hands are essential for channel modulation, CDI inhibition does not require functional CaBP1 EF hands. Furthermore, CaBP1-mediated CDF has different molecular requirements than CaM-mediated CDF. Overall, the data show that CaBP1 comprises two structural modules having separate functions: similar to CaM, the CaBP1 C-lobe serves as a high-affinity anchor that binds the Ca(V)1.2 IQ domain at a site that overlaps with the Ca²+/CaM C-lobe site, whereas the N-lobe/linker module houses the elements required for channel modulation. Discovery of this division provides the framework for understanding how CaBP1 regulates Ca(V)s. Copyright © 2010 Elsevier Ltd. All rights reserved.

  7. Elementary properties of CaV1.3 Ca2+ channels expressed in mouse cochlear inner hair cells

    Science.gov (United States)

    Zampini, Valeria; Johnson, Stuart L; Franz, Christoph; Lawrence, Neil D; Münkner, Stefan; Engel, Jutta; Knipper, Marlies; Magistretti, Jacopo; Masetto, Sergio; Marcotti, Walter

    2010-01-01

    Mammalian cochlear inner hair cells (IHCs) are specialized to process developmental signals during immature stages and sound stimuli in adult animals. These signals are conveyed onto auditory afferent nerve fibres. Neurotransmitter release at IHC ribbon synapses is controlled by L-type CaV1.3 Ca2+ channels, the biophysics of which are still unknown in native mammalian cells. We have investigated the localization and elementary properties of Ca2+ channels in immature mouse IHCs under near-physiological recording conditions. CaV1.3 Ca2+ channels at the cell pre-synaptic site co-localize with about half of the total number of ribbons present in immature IHCs. These channels activated at about −70 mV, showed a relatively short first latency and weak inactivation, which would allow IHCs to generate and accurately encode spontaneous Ca2+ action potential activity characteristic of these immature cells. The CaV1.3 Ca2+ channels showed a very low open probability (about 0.15 at −20 mV: near the peak of an action potential). Comparison of elementary and macroscopic Ca2+ currents indicated that very few Ca2+ channels are associated with each docked vesicle at IHC ribbon synapses. Finally, we found that the open probability of Ca2+ channels, but not their opening time, was voltage dependent. This finding provides a possible correlation between presynaptic Ca2+ channel properties and the characteristic frequency/amplitude of EPSCs in auditory afferent fibres. PMID:19917569

  8. Elementary properties of CaV1.3 Ca(2+) channels expressed in mouse cochlear inner hair cells.

    Science.gov (United States)

    Zampini, Valeria; Johnson, Stuart L; Franz, Christoph; Lawrence, Neil D; Münkner, Stefan; Engel, Jutta; Knipper, Marlies; Magistretti, Jacopo; Masetto, Sergio; Marcotti, Walter

    2010-01-01

    Mammalian cochlear inner hair cells (IHCs) are specialized to process developmental signals during immature stages and sound stimuli in adult animals. These signals are conveyed onto auditory afferent nerve fibres. Neurotransmitter release at IHC ribbon synapses is controlled by L-type Ca(V)1.3 Ca(2+) channels, the biophysics of which are still unknown in native mammalian cells. We have investigated the localization and elementary properties of Ca(2+) channels in immature mouse IHCs under near-physiological recording conditions. Ca(V)1.3 Ca(2+) channels at the cell pre-synaptic site co-localize with about half of the total number of ribbons present in immature IHCs. These channels activated at about 70 mV, showed a relatively short first latency and weak inactivation, which would allow IHCs to generate and accurately encode spontaneous Ca(2+) action potential activity characteristic of these immature cells. The Ca(V)1.3 Ca(2+) channels showed a very low open probability (about 0.15 at 20 mV: near the peak of an action potential). Comparison of elementary and macroscopic Ca(2+) currents indicated that very few Ca(2+) channels are associated with each docked vesicle at IHC ribbon synapses. Finally, we found that the open probability of Ca(2+) channels, but not their opening time, was voltage dependent. This finding provides a possible correlation between presynaptic Ca(2+) channel properties and the characteristic frequency/amplitude of EPSCs in auditory afferent fibres.

  9. Electronic structures and magnetism of CaFeAsH and CaFeAsF

    International Nuclear Information System (INIS)

    Wang Guangtao; Shi Xianbiao; Liu Haipeng; Liu Qingbo

    2015-01-01

    We studied the electronic structures, magnetism, and Fermi surface (FS) nesting of CaFeAsH and CaFeAsF by first-principles calculations. In the nonmagnetic (NM) states, we found strong FS nesting, which induces magnetic instability and a spin density wave (SDW). Our calculations indicate that the ground state of CaFeAsH and CaFeAsF is the stripe antiferromagnetic state. The calculated bare susceptibility χ 0 (q) peaked at the M-point and was clearly suppressed and became slightly incommensurate with both electron doping and hole doping for both materials. (author)

  10. Physical conditions in CaFe interstellar clouds

    OpenAIRE

    Gnacinski, P.; Krogulec, M.

    2007-01-01

    Interstellar clouds that exhibit strong Ca I and Fe I lines were called CaFe clouds. The ionisation equilibrium equations were used to model the column densities of Ca II, Ca I, K I, Na I, Fe I and Ti II in CaFe clouds. The chemical composition of CaFe clouds is that of the Solar System and no depletion of elements onto dust grains is seen. The CaFe clouds have high electron densities n=1 cm^-3 that leads to high column densities of neutral Ca and Fe.

  11. Ca 3d unoccupied states in Bi2Sr2CaCu2O8 investigated by Ca L2,3 x-ray-absorption near-edge structure

    International Nuclear Information System (INIS)

    Borg, A.; King, P.L.; Pianetta, P.; Lindau, I.; Mitzi, D.B.; Kapitulnik, A.; Soldatov, A.V.; Della Longa, S.; Bianconi, A.

    1992-01-01

    The high-resolution Ca L 2,3 x-ray-absorption near-edge-structure (XANES) spectrum of a Bi 2 Sr 2 CaCu 2 O 8 single crystal has been measured by use of a magnetic-projection x-ray microscope probing a surface area of 200x200 μm 2 . The Ca L 2,3 XANES spectrum is analyzed by performing a multiple-scattering XANES calculation in real space and comparing the results with the spectrum of CaF 2 . Good agreement between the calculated and experimental crystal-field splitting Δ f of the Ca 3d final states is found and the splitting is shown to be smaller by 0.5 eV than in the initial state. The Ca 3d partial density of states is found to be close to the Fermi level in the initial state. The Ca-O(in plane) distance is shown to be a critical parameter associated with the shift of the Ca 3d states relative to the Fermi level; in particular, we have studied the effect of the out-of-plane dimpling mode of the in-plane oxygen atoms O(in plane) that will move the Ca 3d states on or off the Fermi level. This mode can therefore play a role in modulating the charge transfer between the two CuO 2 planes separated by the Ca ions

  12. Ca 3d unoccupied states in Bi2Sr2CaCu2O8 investigated by Ca L2,3 x-ray-absorption near-edge structure

    Energy Technology Data Exchange (ETDEWEB)

    Borg, A; King, P L; Pianetta, P; Lindau, I; Mitzi, D B

    1992-01-01

    The high-resolution Ca L(2,3) x-ray-absorption near-edge-structure (XANES) spectrum of a Bi2Sr2CaCu2O8 single crystal has been measured by use of a magnetic-projection x-ray microscope probing a surface area of 200x200 micrometers square. The Ca L(2,3) XANES spectrum is analyzed by performing a multiple-scattering XANES calculation in real space and comparing the results with the spectrum of CaF2. Good agreement between the calculated and experimental crystal-field splitting Delta f of the Ca 3d final states is found and the splitting is shown to be smaller by 0.5 eV than in the initial state. The Ca 3d partial density of states is found to be close to the Fermi level in the initial state. The Ca-O (in plane) distance is shown to be a critical parameter associated with the shift of the Ca 3d states relative to the Fermi level; in particular, the authors have studied the effect of the out-of-plane dimpling mode of the in-plane oxygen atoms O(in plane) that will move the Ca 3d states on or off the Fermi level. This mode can therefore play a role in modulating the charge transfer between the two CuO2 planes separated by the Ca ions.

  13. Practices and Procedures to Prevent the Transmission of Skin and Soft Tissue Infections in High School Athletes

    Science.gov (United States)

    Fritz, Stephanie A.; Long, Marcus; Gaebelein, Claude J.; Martin, Madeline S.; Hogan, Patrick G.; Yetter, John

    2012-01-01

    Skin and soft tissue infections (SSTIs) are frequent in student athletes and are often caused by community-associated methicillin-resistant "Staphylococcus aureus" (CA-MRSA). We evaluated the awareness of CA-MRSA among high school coaches and athletic directors in Missouri (n = 4,408) and evaluated hygiene practices affecting SSTI…

  14. Controls over δ44/40Ca and Sr/Ca variations in coccoliths: New perspectives from laboratory cultures and cellular models

    Science.gov (United States)

    Mejía, Luz María; Paytan, Adina; Eisenhauer, Anton; Böhm, Florian; Kolevica, Ana; Bolton, Clara; Méndez-Vicente, Ana; Abrevaya, Lorena; Isensee, Kirsten; Stoll, Heather

    2018-01-01

    Coccoliths comprise a major fraction of the global carbonate sink. Therefore, changes in coccolithophores' Ca isotopic fractionation could affect seawater Ca isotopic composition, affecting interpretations of the global Ca cycle and related changes in seawater chemistry and climate. Despite this, a quantitative interpretation of coccolith Ca isotopic fractionation and a clear understanding of the mechanisms driving it are not yet available. Here, we address this gap in knowledge by developing a simple model (CaSri-Co) to track coccolith Ca isotopic fractionation during cellular Ca uptake and allocation to calcification. We then apply it to published and new δ 44 / 40 Ca and Sr/Ca data of cultured coccolithophores of the species Emiliania huxleyi and Gephyrocapsa oceanica. We identify changes in calcification rates, Ca retention efficiency and solvation-desolvation rates as major drivers of the Ca isotopic fractionation and Sr/Ca variations observed in cultures. Higher calcification rates, higher Ca retention efficiencies and lower solvation-desolvation rates increase both coccolith Ca isotopic fractionation and Sr/Ca. Coccolith Ca isotopic fractionation is most sensitive to changes in solvation-desolvation rates. Changes in Ca retention efficiency may be a major driver of coccolith Sr/Ca variations in cultures. We suggest that substantial changes in the water structure strength caused by past changes in temperature could have induced significant changes in coccolithophores' Ca isotopic fractionation, potentially having some influence on seawater Ca isotopic composition. We also suggest a potential effect on Ca isotopic fractionation via modification of the solvation environment through cellular exudates, a hypothesis that remains to be tested.

  15. In-situ thermal analysis and macroscopical characterization of Mg-xCa and Mg-0.5Ca-xZn alloy systems

    Energy Technology Data Exchange (ETDEWEB)

    Farahany, Saeed [Department of Materials Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor (Malaysia); Bakhsheshi-Rad, Hamid Reza, E-mail: Rezabakhsheshi@gmail.com [Department of Materials Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor (Malaysia); Idris, Mohd Hasbullah [Department of Materials Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor (Malaysia); Abdul Kadir, Mohammed Rafiq [Medical Implants Technology Group, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor (Malaysia); Department of Biomechanics and Biomedical Materials, Faculty of Biomedical Engineering and Health Sciences, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor (Malaysia); Lotfabadi, Amir Fereidouni [Department of Manufacturing and Industrial Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor (Malaysia); Ourdjini, Ali [Department of Materials Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor (Malaysia)

    2012-01-10

    Highlights: Black-Right-Pointing-Pointer The effect of Ca and Zn addition on Mg-Ca and Mg-Ca-Zn were investigated. Black-Right-Pointing-Pointer Ca and Zn addition decreased solid fraction at coherency point. Black-Right-Pointing-Pointer T{sub N}-T{sub DCP} increased by adding Ca and Zn in Mg-Ca and Mg-Ca-Zn, respectively. Black-Right-Pointing-Pointer Three reactions were detected when Zn/Ca atomic ratio less than 1.25 in Mg-Ca-Zn. Black-Right-Pointing-Pointer A new peak Mg{sub 51}Zn{sub 20} was identified in Mg-0.5Ca-9Zn in addition of other peaks. - Abstract: This research described the identification phases by thermal analysis and microscopy inspection of Mg-xCa and Mg-0.5%Ca-xZn alloys that were solidified at slow cooling rate. Analysis of cooling curve after Ca addition shows the evolution of the Mg{sub 2}Ca intermetallic phase at around 520 Degree-Sign C in addition to {alpha}-Mg phase. First derivative curves of alloys after the addition of Zn to Mg-0.5Ca alloy reveals three peaks related to {alpha}-Mg, Mg{sub 2}Ca and Ca{sub 2}Mg{sub 6}Zn{sub 3} for alloys that have Zn/Ca atomic ratio less than 1.23. The peak of Mg{sub 2}Ca reaction on the first derivative curves disappeared for alloys containing Zn/Ca ratio more than 1.23. A new peak was also observed at 330 Degree-Sign C for Mg-0.5Ca-9Zn which was identified as Mg{sub 51}Zn{sub 20}. Solid fraction at coherency point decreased with increasing Ca and Zn elements. However, coherency time and difference between the nucleation and coherency temperatures (T{sub N}-T{sub DCP}) increased by adding Ca and Zn in Mg-Ca and Mg-Ca-Zn systems.

  16. Synthesis of Al₂Ca Dispersoids by Powder Metallurgy Using a Mg-Al Alloy and CaO Particles.

    Science.gov (United States)

    Fujita, Junji; Umeda, Junko; Kondoh, Katsuyoshi

    2017-06-28

    The elemental mixture of Mg-6 wt %Al-1 wt %Zn-0.3 wt %Mn (AZ61B) alloy powder and CaO particles was consolidated by an equal-channel angular bulk mechanical alloying (ECABMA) process to form a composite precursor. Subsequently, the precursor was subjected to a heat treatment to synthesize fine Al₂Ca particles via a solid-state reaction between the Mg-Al matrix and CaO additives. Scanning electron microscopy-energy-dispersive spectroscopy (SEM-EDS) and electron probe micro-analysis on the precursor indicated that 4.7-at % Al atoms formed a supersaturated solid solution in the α-Mg matrix. Transmission electron microscopy-EDS and X-ray diffraction analyses on the AZ61B composite precursor with 10-vol % CaO particles obtained by heat treatment confirmed that CaO additives were thermally decomposed in the Mg-Al alloy, and the solid-soluted Ca atoms diffused along the α-Mg grain boundaries. Al atoms also diffused to the grain boundaries because of attraction to the Ca atoms resulting from a strong reactivity between Al and Ca. As a result, needle-like (Mg,Al)₂Ca intermetallics were formed as intermediate precipitates in the initial reaction stage during the heat treatment. Finally, the precipitates were transformed into spherical Al₂Ca particles by the substitution of Al atoms for Mg atoms in (Mg,Al)₂Ca after a long heat treatment.

  17. βCaMKII plays a nonenzymatic role in hippocampal synaptic plasticity and learning by targeting αCaMKII to synapses.

    Science.gov (United States)

    Borgesius, Nils Z; van Woerden, Geeske M; Buitendijk, Gabrielle H S; Keijzer, Nanda; Jaarsma, Dick; Hoogenraad, Casper C; Elgersma, Ype

    2011-07-13

    The calcium/calmodulin-dependent kinase type II (CaMKII) holoenzyme of the forebrain predominantly consists of heteromeric complexes of the αCaMKII and βCaMKII isoforms. Yet, in contrast to αCaMKII, the role of βCaMKII in hippocampal synaptic plasticity and learning has not been investigated. Here, we compare two targeted Camk2b mouse mutants to study the role of βCaMKII in hippocampal function. Using a Camk2b(-/-) mutant, in which βCaMKII is absent, we show that both hippocampal-dependent learning and Schaffer collateral-CA1 long-term potentiation (LTP) are highly dependent upon the presence of βCaMKII. We further show that βCaMKII is required for proper targeting of αCaMKII to the synapse, indicating that βCaMKII regulates the distribution of αCaMKII between the synaptic pool and the adjacent dendritic shaft. In contrast, localization of αCaMKII, hippocampal synaptic plasticity and learning were unaffected in the Camk2b(A303R) mutant, in which the calcium/calmodulin-dependent activation of βCaMKII is prevented, while the F-actin binding and bundling property is preserved. This indicates that the calcium/calmodulin-dependent kinase activity of βCaMKII is fully dispensable for hippocampal learning, LTP, and targeting of αCaMKII, but implies a critical role for the F-actin binding and bundling properties of βCaMKII in synaptic function. Together, our data provide compelling support for a model of CaMKII function in which αCaMKII and βCaMKII act in concert, but with distinct functions, to regulate hippocampal synaptic plasticity and learning.

  18. Impact of seawater [Ca2+] on the calcification and calcite Mg / Ca of Amphistegina lessonii

    NARCIS (Netherlands)

    Mewes, A.; Langer, G.; Thoms, S.; Nehrke, G.; Reichart, G. J.; de Nooijer, L. J.; Bijma, J.

    2015-01-01

    Mg / Ca ratios in foraminiferal tests are routinely used as paleotemperature proxies, but on long timescales, they also hold the potential to reconstruct past seawater Mg / Ca. The impact of both temperature and seawater Mg / Ca on Mg incorporation in Foraminifera has been quantified by a number of

  19. Annual Gaseous Electronics Conference (38th) Held at Monterey, California on 15-18 October 1985. Program and Abstracts.

    Science.gov (United States)

    1985-10-18

    al and CB- 8 PLASMA-SHEATH STRUCTURE FOR AN t GM ELECTRODE CONTACTING AN ISOTHERMAL CA-17 SYNCHROTRON STUDIES OF COLLISION PLASMA: I. FORMULATION AND...77, 817 (1982). 25 S.2’ CA CA-17 Synchrotron Studies of Collision Induced Absorp- tion and Emission in 12 and IC. D. C. LORENTS, AND R. L. SHARPLESS...Aiken June 1954 Gardner, Milton Eugene June 1937 Huber, Elsa Louise June 1954 Bowls, Noodford Eugene Nov. 1937 Maunsell. Charles Dudley Jan. 1955 Chapman

  20. CaWRKY22 Acts as a Positive Regulator in Pepper Response to Ralstonia Solanacearum by Constituting Networks with CaWRKY6, CaWRKY27, CaWRKY40, and CaWRKY58

    OpenAIRE

    Ansar Hussain; Xia Li; Yahong Weng; Zhiqin Liu; Muhammad Furqan Ashraf; Ali Noman; Sheng Yang; Muhammad Ifnan; Shanshan Qiu; Yingjie Yang; Deyi Guan; Shuilin He

    2018-01-01

    The WRKY web, which is comprised of a subset of WRKY transcription factors (TFs), plays a crucial role in the regulation of plant immunity, however, the mode of organization and operation of this network remains obscure, especially in non-model plants such as pepper (Capsicum annuum). Herein, CaWRKY22, a member of a subgroup of IIe WRKY proteins from pepper, was functionally characterized in pepper immunity against Ralstonia Solanacearum. CaWRKY22 was found to target the nuclei, and its trans...

  1. Studies of highly ionized atoms using internal conversion: 197Au, 57Fe; electric monopole transitions in 40Ca, 42Ca, and 44Ca

    International Nuclear Information System (INIS)

    Ulrickson, M.A.

    1975-01-01

    By using heavy-ion reactions, highly ionized electronic states of atoms may be produced. The interaction between excited nuclear levels and the surrounding atomic electrons via internal conversion allows the nucleus to be used as a probe of the electronic structure of the highly ionized atoms. Studies of such atoms were undertaken for strongly internally converted nuclear levels in 197 Au and 57 Fe. The nuclear levels were Coulomb excited by using 16 O and 32 S beams. Simultaneous measurement of the lifetime of the 77-keV state of 197 Au in both neutral gold atoms and gold atoms with mean charge +10 resulted in a measured change in the internal conversion coefficient of Δalpha/alpha equals - 1.7 +- 3.0)10 -3 . This result is consistent with calculations using a Hartree-Fock--Slater program. Measurements of the electric monopole strengths for 0 + → 0 + transitions were undertaken to determine the amount of core-deformation in calcium nuclei. The E0 strengths for the decays of the 0 + states at 5.21 MeV in 40 C, 1.84 MeV in 42 Ca, and 1.88 MeV in 44 Ca were observed. The branching ratios for the subsequent E0 pair decays were measured by observing the coincident annihilation radiation from the e + member of the pair in coincidence with protons feeding the state in the cases of 42 Ca and 44 Ca, and by observing the actual coincident e + --e - pair together with protons feeding the state in the case of 40 Ca. The resulting E0 strengths (rho less than or equal to 0.06, rho = 0.34 +- 0.03, rho = 0.30 +- 0.10 for 40 Ca, 42 Ca, and 44 Ca respectively) agree with theoretical descriptions

  2. Structural and compositional characterization of synthetic (Ca,Sr)-tremolite and (Ca,Sr)-diopside solid solutions

    Science.gov (United States)

    Gottschalk, M.; Najorka, J.; Andrut, M.

    Tremolite (CaxSr1-x)2Mg5[Si8O22/(OH)2] and diopside (CaxSr1-x)Mg[Si2O6] solid solutions have been synthesized hydrothermally in equilibrium with a 1 molar (Ca,Sr)Cl2 aqueous solution at 750°C and 200 MPa. The solid run products have been investigated by optical, electron scanning and high resolution transmission electron microscopy, electron microprobe, X-ray-powder diffraction and Fourier-transform infrared spectroscopy. The synthesized (Ca,Sr)-tremolites are up to 2000 µm long and 30 µm wide, the (Ca,Sr)-diopsides are up to 150 µm long and 20 µm wide. In most runs the tremolites and diopsides are well ordered and chain multiplicity faults are rare. Nearly pure Sr-tremolite (tr0.02Sr-tr0.98) and Sr-diopside (di0.01Sr-di0.99) have been synthesized. A continuous solid solution series, i.e. complete substitution of Sr2+ for Ca2+ on M4-sites exists for (Ca,Sr)-tremolite. Total substitution of Sr2+ for Ca2+ on M2-sites can be assumed for (Ca,Sr)-diopsides. For (Ca,Sr)-tremolites the lattice parameters a, b and β are linear functions of composition and increase with Sr-content whereas c is constant. For the diopside series all 4 lattice parameters are a linear function of composition; a, b, c increase and β decreases with rising Sr-content. The unit cell volume for tremolite increases 3.47% from 906.68 Å3 for tremolite to 938.21 Å3 for Sr-tremolite. For diopside the unit cell volume increases 4.87 % from 439.91 Å3 for diopside to 461.30 Å3 for Sr-diopside. The observed splitting of the OH stretching band in tremolite is caused by different configurations of the next nearest neighbors (multi mode behavior). Resolved single bands can be attributed to the following configurations on the M4-sites: SrSr, SrCa, CaCa and CaMg. The peak positions of these 4 absorption bands are a linear function of composition. They are shifted to lower wavenumbers with increasing Sr-content. No absorption band due to the SrMg configuration on the M4-site is observed. This indicates

  3. Formation of CaB6 in the thermal decomposition of the hydrogen storage material Ca(BH4)2.

    Science.gov (United States)

    Sahle, Christoph J; Sternemann, Christian; Giacobbe, Carlotta; Yan, Yigang; Weis, Christopher; Harder, Manuel; Forov, Yury; Spiekermann, Georg; Tolan, Metin; Krisch, Michael; Remhof, Arndt

    2016-07-20

    Using a combination of high resolution X-ray powder diffraction and X-ray Raman scattering spectroscopy at the B K- and Ca L2,3-edges, we analyzed the reaction products of Ca(BH4)2 after annealing at 350 °C and 400 °C under vacuum conditions. We observed the formation of nanocrystalline/amorphous CaB6 mainly and found only small contributions from amorphous B for annealing times larger than 2 h. For short annealing times of 0.5 h at 400 °C we observed neither CaB12H12 nor CaB6. The results indicate a reaction pathway in which Ca(BH4)2 decomposes to B and CaH2 and finally reacts to form CaB6. These findings confirm the potential of using Ca(BH4)2 as a hydrogen storage medium and imply the desired cycling capabilities for achieving high-density hydrogen storage materials.

  4. Ca2+/Calmodulin-Dependent Protein Kinase Kinases (CaMKKs) Effects on AMP-Activated Protein Kinase (AMPK) Regulation of Chicken Sperm Functions.

    Science.gov (United States)

    Nguyen, Thi Mong Diep; Combarnous, Yves; Praud, Christophe; Duittoz, Anne; Blesbois, Elisabeth

    2016-01-01

    Sperm require high levels of energy to ensure motility and acrosome reaction (AR) accomplishment. The AMP-activated protein kinase (AMPK) has been demonstrated to be strongly involved in the control of these properties. We address here the question of the potential role of calcium mobilization on AMPK activation and function in chicken sperm through the Ca(2+)/calmodulin-dependent protein kinase kinases (CaMKKs) mediated pathway. The presence of CaMKKs and their substrates CaMKI and CaMKIV was evaluated by western-blotting and indirect immunofluorescence. Sperm were incubated in presence or absence of extracellular Ca(2+), or of CaMKKs inhibitor (STO-609). Phosphorylations of AMPK, CaMKI, and CaMKIV, as well as sperm functions were evaluated. We demonstrate the presence of both CaMKKs (α and β), CaMKI and CaMKIV in chicken sperm. CaMKKα and CaMKI were localized in the acrosome, the midpiece, and at much lower fluorescence in the flagellum, whereas CaMKKβ was mostly localized in the flagellum and much less in the midpiece and the acrosome. CaMKIV was only present in the flagellum. The presence of extracellular calcium induced an increase in kinases phosphorylation and sperm activity. STO-609 reduced AMPK phosphorylation in the presence of extracellular Ca(2+) but not in its absence. STO-609 did not affect CaMKIV phosphorylation but decreased CaMKI phosphorylation and this inhibition was quicker in the presence of extracellular Ca(2+) than in its absence. STO-609 efficiently inhibited sperm motility and AR, both in the presence and absence of extracellular Ca(2+). Our results show for the first time the presence of CaMKKs (α and β) and one of its substrate, CaMKI in different subcellular compartments in germ cells, as well as the changes in the AMPK regulation pathway, sperm motility and AR related to Ca(2+) entry in sperm through the Ca(2+)/CaM/CaMKKs/CaMKI pathway. The Ca(2+)/CaMKKs/AMPK pathway is activated only under conditions of extracellular Ca(2+) entry

  5. Ca2+/Calmodulin-Dependent Protein Kinase Kinases (CaMKKs Effects on AMP-Activated Protein Kinase (AMPK Regulation of Chicken Sperm Functions.

    Directory of Open Access Journals (Sweden)

    Thi Mong Diep Nguyen

    Full Text Available Sperm require high levels of energy to ensure motility and acrosome reaction (AR accomplishment. The AMP-activated protein kinase (AMPK has been demonstrated to be strongly involved in the control of these properties. We address here the question of the potential role of calcium mobilization on AMPK activation and function in chicken sperm through the Ca(2+/calmodulin-dependent protein kinase kinases (CaMKKs mediated pathway. The presence of CaMKKs and their substrates CaMKI and CaMKIV was evaluated by western-blotting and indirect immunofluorescence. Sperm were incubated in presence or absence of extracellular Ca(2+, or of CaMKKs inhibitor (STO-609. Phosphorylations of AMPK, CaMKI, and CaMKIV, as well as sperm functions were evaluated. We demonstrate the presence of both CaMKKs (α and β, CaMKI and CaMKIV in chicken sperm. CaMKKα and CaMKI were localized in the acrosome, the midpiece, and at much lower fluorescence in the flagellum, whereas CaMKKβ was mostly localized in the flagellum and much less in the midpiece and the acrosome. CaMKIV was only present in the flagellum. The presence of extracellular calcium induced an increase in kinases phosphorylation and sperm activity. STO-609 reduced AMPK phosphorylation in the presence of extracellular Ca(2+ but not in its absence. STO-609 did not affect CaMKIV phosphorylation but decreased CaMKI phosphorylation and this inhibition was quicker in the presence of extracellular Ca(2+ than in its absence. STO-609 efficiently inhibited sperm motility and AR, both in the presence and absence of extracellular Ca(2+. Our results show for the first time the presence of CaMKKs (α and β and one of its substrate, CaMKI in different subcellular compartments in germ cells, as well as the changes in the AMPK regulation pathway, sperm motility and AR related to Ca(2+ entry in sperm through the Ca(2+/CaM/CaMKKs/CaMKI pathway. The Ca(2+/CaMKKs/AMPK pathway is activated only under conditions of extracellular Ca(2

  6. Dynamic immobilization of simulated radionuclide 133Cs in soil by thermal treatment/vitrification with nanometallic Ca/CaO composites

    International Nuclear Information System (INIS)

    Mallampati, Srinivasa Reddy; Mitoma, Yoshiharu; Okuda, Tetsuji; Simion, Cristian; Lee, Byeong Kyu

    2015-01-01

    Although direct radiation induced health impacts were considered benign, soil contamination with 137 Cs, due to its long-term radiological impact (30 years half-life) and its high biological availability is of a major concern in Japan in the aftermath of the Fukushima nuclear power plant disaster. Therefore 137 Cs reduction and immobilization in contaminated soil are recognized as important problems to be solved using suitable and effective technologies. One such thermal treatment/vitrification with nanometallic Ca/CaO amendments is a promising treatment for the ultimate immobilization of simulated radionuclide 133 Cs in soil, showing low leachability and zero evaporation. Immobilization efficiencies were 88%, 95% and 96% when the 133 Cs soil was treated at 1200 °C with activated carbon, fly ash and nanometallic Ca/CaO additives. In addition, the combination of nanometallic Ca/CaO and fly ash (1:1) enhanced the immobilization efficiency to 99%, while no evaporation of 133 Cs was observed. At lower temperatures (800 °C) the leachable fraction of Cs was only 6% (94% immobilization). Through the SEM–EDS analysis, decrease in the amount of Cs mass percent detectable on soil particle surface was observed after soil vitrified with nCa/CaO + FA. The 133 Cs soil was subjected to vitrified with nCa/CaO + FA peaks related to Ca, crystalline phases (CaCO 3 /Ca(OH) 2 ), wollastonite, pollucite and hematite appeared in addition to quartz, kaolinite and bentonite, which probably indicates that the main fraction of enclosed/bound materials includes Ca-associated complexes. Thus, the thermal treatment with the addition of nanometallic Ca/CaO and fly ash may be considered potentially applicable for the remediation of radioactive Cs contaminated soil at zero evaporation, relatively at low temperature. - Graphical abstract: SEM–EDS element maps of 133 Cs contaminated soil before and after thermal treatment at 1200 °C with different addictives. Color intensity for Cs is from 0

  7. Anti-tumor activity of self-charged (Eu,Ca):WO3 and Eu:CaWO4 nanoparticles

    International Nuclear Information System (INIS)

    Lin, Cao; Cong, Wang; De'An, Pan; Jiexin, Cao; Ping, Che; Volinsky, Alex A.

    2012-01-01

    Non-stoichiometric (Eu,Ca):WO 3 and Eu:CaWO 4 nanoparticles with anti-tumor activity are synthesized in a sol-gel method by adding excessive Eu 3+ and Ca 2+ ions to tungsten oxide crystal structure. Colorimetric assay shows that 10 nm (Eu,Ca):WO 3 and Eu:CaWO 4 nanoparticles can effectively inhibit growth of mammary cancer cells without any harm to normal cells. Nanoparticles are characterized by X-ray diffraction, high resolution transmission electron microscopy and fluorescence optical spectrometry. Nanomaterials, insoluble in synthesized water, have complicated self-charging surfaces that trap mammary cancer cells. Surface self-charging effect is suggested as the inhibition mechanism. (author)

  8. PGC-1{alpha} accelerates cytosolic Ca{sup 2+} clearance without disturbing Ca{sup 2+} homeostasis in cardiac myocytes

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Min, E-mail: chenminyx@gmail.com [Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing 100871 (China); Yunnan Centers for Diseases Prevention and Control, Kunming 650022 (China); Wang, Yanru [Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing 100871 (China); Qu, Aijuan [Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (United States)

    2010-06-11

    Energy metabolism and Ca{sup 2+} handling serve critical roles in cardiac physiology and pathophysiology. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1{alpha}) is a multi-functional coactivator that is involved in the regulation of cardiac mitochondrial functional capacity and cellular energy metabolism. However, the regulation of PGC-1{alpha} in cardiac Ca{sup 2+} signaling has not been fully elucidated. To address this issue, we combined confocal line-scan imaging with off-line imaging processing to characterize calcium signaling in cultured adult rat ventricular myocytes expressing PGC-1{alpha} via adenoviral transduction. Our data shows that overexpressing PGC-1{alpha} improved myocyte contractility without increasing the amplitude of Ca{sup 2+} transients, suggesting that myofilament sensitivity to Ca{sup 2+} increased. Interestingly, the decay kinetics of global Ca{sup 2+} transients and Ca{sup 2+} waves accelerated in PGC-1{alpha}-expressing cells, but the decay rate of caffeine-elicited Ca{sup 2+} transients showed no significant change. This suggests that sarcoplasmic reticulum (SR) Ca{sup 2+}-ATPase (SERCA2a), but not Na{sup +}/Ca{sup 2+} exchange (NCX) contribute to PGC-1{alpha}-induced cytosolic Ca{sup 2+} clearance. Furthermore, PGC-1{alpha} induced the expression of SERCA2a in cultured cardiac myocytes. Importantly, overexpressing PGC-1{alpha} did not disturb cardiac Ca{sup 2+} homeostasis, because SR Ca{sup 2+} load and the propensity for Ca{sup 2+} waves remained unchanged. These data suggest that PGC-1{alpha} can ameliorate cardiac Ca{sup 2+} cycling and improve cardiac work output in response to physiological stress. Unraveling the PGC-1{alpha}-calcium handing pathway sheds new light on the role of PGC-1{alpha} in the therapy of cardiac diseases.

  9. A critical comparison of the current view of Ca signaling with the novel concept of F-actin-based Ca signaling.

    Science.gov (United States)

    Lange, Klaus; Gartzke, Joachim

    2006-01-01

    A detailed comparative survey on the current idea of Ca signaling and the alternative concept of F-actin-based Ca signaling is given. The two hypotheses differ in one central aspect - the mechanism of Ca storage. The current theory rests on the assumption of Ca-accumulating vesicles derived from the endoplasmic/ sarcoplasmic reticulum, which are equipped with an ATP-dependent Ca pump and IP3- or ryanodine-sensitive Ca-release channels/receptors. The alternative hypothesis proceeds from the idea of Ca storage at the high-affinity binding sites of F-actin subunits. Several prominent features of Ca signaling, which are not adequately described by the current concept, are inherent properties of the F-actin system and its dynamic state of treadmilling. F-actin is the only known biological Ca-binding system that has been proven by in vitro experiments to work within the physiological range of Ca concentrations and the only system that meets all necessary conditions to function as receptor-operated Ca store and as a coupling device between the Ca store and the store-operated Ca influx pathway. The most important properties of Ca signaling, such as store-channel coupling, quantal Ca release, spiking and oscillations, biphasic and "phasic" uptake kinetics, and Ca-induced Ca release, turn out to be systematic features of the new concept but remain unexplained by the classical vesicle storage hypothesis. A number of novel findings, specifically recent reports about direct effects of actin-specific toxins on Ca stores, have strengthened the new concept. The concept of F-actin-based Ca signaling combined with the notion of microvillar regulation of ion and substrate fluxes opens new aspects and far-reaching consequences, not only for cellular Ca signaling but also for various other cell functions, and represents an opportunity to connect several fields of cell physiology on the basis of a common mechanism.

  10. Study on Ca2+ antagonistic effect and mechanism of Chinese herbal drugs using 45Ca

    International Nuclear Information System (INIS)

    Yang Yuanyou; Liu Ning; Mo Shangwu; Qiu Mingfeng; Jin Jiannan; Liao Jiali

    2002-01-01

    The Ca 2+ antagonistic effect and mechanism of Chinese herbal drugs are studied by using 45 Ca. The results indicate that potential-dependent Ca 2+ channel (PDC) and receptor-operated Ca 2+ channel (ROC) in cell membranes of smooth muscle can be blocked by several Chinese herbal drugs, including as Crocus sativus L., Carthamus L., Di-ao-xin-xue-kang (DAXXG) and Ginkgo biloba L. leaves. Among them Crocus sativus L. has the strongest antagonistic effect on Ca 2+ channel, while Ginkgo biloba L. leaves has no obvious effect. The whole prescription and the other functional drugs have significant effect on ROC and PDC. The compositions extracted by hexane have the strongest antagonistic. The wrinkled giant hyssop have five active compositions and Pei-lan have two active compositions

  11. Cost, Schedule, And Performance Elements For Comparison of Hydrodynamic Models of Near-Surface Unmanned Underwater Vehicle Operations

    Science.gov (United States)

    2017-12-01

    2-89) Prescribed by ANSI Std. 239-18 ii THIS PAGE INTENTIONALLY LEFT BLANK iii Approved for public release. Distribution is unlimited. COST ...from the scope of this demonstration due to time constraints. Further study of this software would benefit similar cost , schedule, and performance...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA SYSTEMS ENGINEERING CAPSTONE PROJECT REPORT Approved for public release. Distribution

  12. Dampening Effects Of Food Importation On Climate Change-Induced Conflict In Africa

    Science.gov (United States)

    2017-12-01

    The validity of those claims, however, remains in question.47 Abundance theory, on the other hand, relies on a similar cost - benefit calculation but...FDRs). These resource fluctuations have the potential to reach levels extreme enough, as indicated in Table 9 results, to alter the cost - benefit ...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. DAMPENING EFFECTS

  13. How The Democratization Of Technology Enhances Intelligence-Led Policing And Serves The Community

    Science.gov (United States)

    2017-12-01

    surveillance cameras further supports cost efficiency. Again, the cameras were city-owned, but the benefit of crime reduction and savings of criminal justice...policing, such as use of informants or disruption techniques, can illustrate the cost - benefit of these strategies.275 Citizens should find satisfaction...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. HOW THE

  14. The Federal Republic of Germany and Left Wing Terrorism

    Science.gov (United States)

    2003-12-01

    the Beatles ! Historically speaking, the soon to be dubbed “68ers”, were extremely conscious of the suppressive and authoritarian Nazi regime that...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release, distribution is unlimited THE FEDERAL REPUBLIC...reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instruction

  15. Styles of International Mediation in Peace Processes Between States and Terrorist Organizations

    Science.gov (United States)

    2016-06-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited STYLES OF...Office of Management and Budget, Paperwork Reduction Project (0704-0188) Washington, DC 20503. 1. AGENCY USE ONLY (Leave blank) 2. REPORT DATE...June 2016 3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE STYLES OF INTERNATIONAL MEDIATION IN PEACE PROCESSES BETWEEN

  16. Search Parameter Optimization for Discrete, Bayesian, and Continuous Search Algorithms

    Science.gov (United States)

    2017-09-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS SEARCH PARAMETER OPTIMIZATION FOR DISCRETE , BAYESIAN, AND CONTINUOUS SEARCH ALGORITHMS by...to 09-22-2017 4. TITLE AND SUBTITLE SEARCH PARAMETER OPTIMIZATION FOR DISCRETE , BAYESIAN, AND CON- TINUOUS SEARCH ALGORITHMS 5. FUNDING NUMBERS 6...simple search and rescue acts to prosecuting aerial/surface/submersible targets on mission. This research looks at varying the known discrete and

  17. Feasibility Analysis and Prototyping of a Fast Autonomous Recon system

    Science.gov (United States)

    2017-06-01

    these systems is a gasoline or jet propellant fueled engine. a. ScanEagle The ScanEagle UAS designed for ISR missions on land or at sea (Insitu...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. FEASIBILITY...ANALYSIS AND PROTOTYPING OF A FAST AUTONOMOUS RECON SYSTEM by Marcus A. Torres June 2017 Thesis Advisor: Oleg A. Yakimenko Second Reader

  18. Sea-Shore Interface Robotic Design

    Science.gov (United States)

    2014-06-01

    for various beachfront terrains. Robotics , Robot , Amphibious Vehicles, Mobility, Surf-Zone, Autonomous, Wheg, exoskeleton Unclassified Unclassified...controllers and to showcase the benefits of a modular construction. The result was an exoskeleton design with modular components, see Figure 2.1. Figure 2.1...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS SEA-SHORE INTERFACE ROBOTIC DESIGN by Timothy L. Bell June 2014 Thesis Advisor: Richard Harkins

  19. Analysis of Naval Ammunition Stock Positioning

    Science.gov (United States)

    2015-12-01

    not manipulated to be in favor of any system based on the assumption that stock positioned closer to demand would result in more favorable delivery...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT ANALYSIS OF NAVAL AMMUNITION STOCK POSITIONING...professional report 4. TITLE AND SUBTITLE ANALYSIS OF NAVAL AMMUNITION STOCK POSITIONING 5. FUNDING NUMBERS 6. AUTHOR(S) David Sharp and Eric

  20. Business Case Analysis of the Marine Corps Base Pendleton Virtual Smart Grid

    Science.gov (United States)

    2017-06-01

    is searching for answers in energy-efficient technology . This study discusses the benefits of using power-modeling software to manage Advanced ...under NIST. 7 Figure 3. A History of NIST and the Smart Grid. Source: NIST (2014). The extension of smart grid technology to include...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. BUSINESS CASE

  1. How to Stop the Bear: Strategy of Small States

    Science.gov (United States)

    2010-12-01

    stressing the role of international law, and abstentionism from security alliance” (George J. Stein, 1990, p. 4). At the same time, the Dutch were reluctant...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited HOW TO STOP THE BEAR...estimated to average 1 hour per response, including the time for reviewing instruction, searching existing data sources, gathering and maintaining

  2. A Comparative Study On The Development Of Civil Military Relations In The Process Of Democratization In South Korea And Taiwan Until 2008

    Science.gov (United States)

    2017-12-01

    Approved for public release. Distribution is unlimited. A COMPARATIVE STUDY ON THE DEVELOPMENT OF CIVIL-MILITARY RELATIONS IN THE PROCESS OF...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. A COMPARATIVE STUDY ON THE...DEVELOPMENT OF CIVIL-MILITARY RELATIONS IN THE PROCESS OF DEMOCRATIZATION IN SOUTH KOREA AND TAIWAN UNTIL 2008 by Sang bum Nam December 2017 Thesis

  3. Ethical Decision-Making for Homeland Security

    Science.gov (United States)

    2013-09-01

    PhD Thesis Co-Advisor Anders Strindberg, PhD Thesis Co-Advisor Mohammed Hafez, PhD Chair, Department of National Security Affairs...expectations may be deleterious in the long-term, emotionally, psychologically , spiritually , and socially (what we label as moral injury)” (Litz 2009). They...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited ETHICAL DECISION

  4. Cybersecurity Education for Military Officers

    Science.gov (United States)

    2017-12-01

    automated artificial intelligence to act at the speed of cyber (S. Jasper, class notes, September 12, 2017). The idea is to limit damage inside your network...we would not want artificial intelligence conducting counter attacks; there needs to be a human in the loop in order to prevent terrible decisions...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT CYBERSECURITY EDUCATION FOR MILITARY OFFICERS

  5. Sociocultural-Geospatial Anthropological Portal (SC-GAP): Enhancing Sociocultural Understanding Through Crowdsourced Service Member Narratives

    Science.gov (United States)

    2015-06-01

    71 Culture is “the normative system and values that people use as guides to their behavior…” defined by Fathali M. Moghaddam, Multiculturalism and...Administration 3, (1951): 56–57. Moghaddam, Fathali M. Multiculturalism and Intergroup Relations: Psychological Implications for Democracy in Global...LIST 1. Defense Technical Information Center Ft. Belvoir, Virginia 2. Dudley Knox Library Naval Postgraduate School Monterey, California

  6. A Market Analysis of Publications, Trade Conferences, and Key Events for Fleet Readiness Center Southwest

    Science.gov (United States)

    2007-12-01

    Win and Keep Big Customers. Austin: Bard Press, 2005. Kotler , Philip and Kevin Lane Keller. Marketing Management. Upper Saddle River, NJ...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT A Market Analysis of Publications, Trade Conferences...AGENCY USE ONLY (Leave blank) 2. REPORT DATE December 2007 3. REPORT TYPE AND DATES COVERED MBA Professional Report 4. TITLE AND SUBTITLE: A Market

  7. An Engineered Resupply System for Humanitarian Assistance and Disaster Relief Operations

    Science.gov (United States)

    2017-09-01

    relevant and timely relief. Conduct Supply refers to the procurement, warehousing, and managing of relief supplies. Conduct Deployment and Distribution ...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. AN ENGINEERED...Approved OMB No. 0704–0188 Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time

  8. A Qualitative Analysis of NASA’s Human Computer Interaction Group Examining the Root Causes of Focusing on Derivative System Improvements Versus Core User Needs

    Science.gov (United States)

    2017-12-01

    toward qualitative analysis methods where they excelled at user research and workflow process analysis consistent with their formal training, rather...to a single one (e.g., one type of user research or graphic design) at larger Silicon Valley firms. The core competency of the design team tended...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT A QUALITATIVE ANALYSIS OF NASA’S HUMAN COMPUTER

  9. Hacking Your Ride: Is Web 2.0 Creating Vulnerabilities To Surface Transportation

    Science.gov (United States)

    2016-09-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. HACKING YOUR RIDE...3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE HACKING YOUR RIDE: IS WEB 2.0 CREATING VULNERABILITIES TO SURFACE...Prescribed by ANSI Std. 239-18 ii THIS PAGE INTENTIONALLY LEFT BLANK iii Approved for public release. Distribution is unlimited. HACKING

  10. Exploration of Logistics Information Technology (IT) Solutions for the Royal Saudi Naval Force Within the Saudi Naval Expansion Program II (SNEP II)

    Science.gov (United States)

    2017-12-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT EXPLORATION OF LOGISTICS INFORMATION TECHNOLOGY (IT) SOLUTIONS FOR THE...INFORMATION TECHNOLOGY (IT) SOLUTIONS FOR THE ROYAL SAUDI NAVAL FORCE WITHIN THE SAUDI NAVAL EXPANSION PROGRAM II (SNEP II) 5. FUNDING NUMBERS 6. AUTHOR(S...Expansion Program II (SNEP II). A part of this program includes upgrading and rebuilding its information technology (IT) infrastructure. The United

  11. Virtual Close Quarter Battle (CQB) Graphical Decision Trainer

    Science.gov (United States)

    2002-09-01

    leave a gap in what would traditionally be thought of as an ideal locomotion device. Research has shown that the introduction of vestibular cues in...NAVAL POSTGRADUATE SCHOOL Monterey, California THESIS VIRTUAL CLOSE QUARTER BATTLE (CQB) GRAPHICAL DECISION TRAINER by Jordan Reece...including suggestions for reducing this burden, to Washington headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson

  12. The Design of a Navigator for a Testbed Autonomous Underwater Vehicle

    Science.gov (United States)

    1989-12-01

    AD-A231 733 NAVAL POSTGRADUATE SCHOOL Monterey, California DTC C ’S B’- i I A VDI ELECTE 1i EB 0 6 991| D THESIS E THE DESIGN OF A NAVIGATOR FOR A...255,255,0); /* yellow (512-1023) * for (i= 1024; i< 2048 ; ++i) mapcolor(i,255 ,0,255); 1* magenta (1024-2047 )*/ color(BLACK); clearo; swapbufferso; 1

  13. Free Convection from a Semi-Infinite Vertical Plate with Discontinuous Blowing or Suction.

    Science.gov (United States)

    1981-03-01

    SCHIESSR UNCLASSIFIED; EhEllllEllEE EE[E]hEEEIllIEllhlEEIl EEEEEIIIEEEEI EEEIIIIIIIIII EIIIEIIEEEEII EEEIIIIIIIIIIE LVEL NAVAL POSTGRADUATE SCHOOL Monterey...the unsteady free convective flow past a simi-infinite porous plate with constant suction were studied through mathematical analysis by Soundalgekar...boundary-layers and; therefore, will often indicate a preferred method of analytical solution. Although there are several possible mathematical techniques

  14. Social Media: New Spaces for Contention In Authoritarian Systems

    Science.gov (United States)

    2015-12-01

    restrictions and controls. Social media became the manner in which protesters used to mobilize as opposed to the traditional manner of word of mouth or...distribution is unlimited 12b. DISTRIBUTION CODE 13. ABSTRACT (maximum 200 words ) What role has social media played in Bahraini political movements...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited SOCIAL MEDIA : NEW

  15. An Analysis of Category Management of Service Contracts

    Science.gov (United States)

    2017-12-01

    comprised of four steps to guide future category management teams in analyzing data and applying Category Management principles through the use of...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT AN ANALYSIS OF CATEGORY MANAGEMENT OF SERVICE CONTRACTS December 2017...Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and to the Office of Management and Budget, Paperwork Reduction Project

  16. Imaging Saltwater Intrusion Along the Coast of Monterey Bay Using Long-Offset Electrical Resistivity Tomography

    Science.gov (United States)

    Goebel, M.; Knight, R. J.; Pidlisecky, A.

    2016-12-01

    Coastal regions represent a complex dynamic interface where saltwater intrusion moves seawater landward and groundwater discharge moves freshwater seaward. These processes can have a dramatic impact on water quality, affecting both humans and coastal ecosystems. The ability to map the subsurface distribution of fresh and salt water is a critical step in predicting and managing water quality in coastal regions. This is commonly accomplished using wells, which are expensive and provide point information, which may fail to capture the spatial complexity in subsurface conditions. We present an alternate method for acquiring data, long-offset Electrical Resistivity Tomography (ERT), which is non-invasive, cost effective, and can address the problem of poor spatial sampling. This geophysical method can produce continuous profiles of subsurface electrical resistivity to a depth of 300 m, with spatial resolution on the order of tens of meters. Our research focuses on the Monterey Bay region, where sustained groundwater extraction over the past century has led to significant saltwater intrusion. ERT was acquired along 40 kilometers of the coast using the roll along method, allowing for continuous overlap in data acquisition. Electrodes were spaced every 22.2 m, with a total of 81 electrodes along the 1.8 km active cable length. The data show a complex distribution of fresh and salt water, influenced by geology, groundwater pumping, recharge, and land-use. While the inverted ERT resistivity profiles correspond well with existing data sets and geologic interpretations in the region, the spatial complexity revealed through the ERT data goes beyond what is known from traditional data sources alone. This leads us to conclude that this form of data can be extremely useful in informing and calibrating groundwater flow models, making targeted management decisions, and monitoring changes in subsurface salinities over time.

  17. Mg/Ca of Continental Ostracode Shells

    Science.gov (United States)

    Ito, E.; Forester, R. M.; Marco-Barba, J.; Mezquita, F.

    2007-12-01

    Marine ionic chemistry is thought to remain constant. This, together with the belief that marine calcifiers partition Mg/Ca in a systematic manner as functions of temperature (and Mg/Ca) of water forms the basis of the Mg/Ca thermometer. In continental settings both of these assumptions are usually not true. Continental waters contain a wide variety of solutes in absolute and relative ion concentrations. Hence, waters with identical Mg/Ca may have very different concentrations of Mg and Ca and very different anions. Here we use two examples to focus on the effects of ion chemistry on Mg/Ca partitioning in continental ostracode shells and we ignore the complexities of solute evolution, which can change Mg/Ca over timescales of minutes to millennia. Palacios-Fest and Dettman (2001) conducted a monthly study of ,Cypridopsis vidua at El Yeso Lake in Sonora, Mexico. They established a relation between temperature and average shell Mg/Ca using regression analyses on averaged data. When their Mg/Ca-temperature relation is applied to monthly ,C. vidua data from Page Pond near Cleveland, Ohio, water temperatures of -8 to -1°C are obtained. The observed Mg/Ca ranges for El Yeso Lake (0.31 to 0.46) and Page Pond (0.33 to 0.46) are similar, as are their specific conductivities (700 to 850μS for El Yeso Lake; 400 to 600μS for Page Pond). However, [Ca] is 140-260 mg/L for El Yeso, but only 70-90 mg/L for Page Pond. Page Pond data, in fact, shows a good temperature shell Mg/Ca relation for .C. vidua, but the relation is different from that at El Yeso. Hence, shell Mg/Ca is a multi-valued, family of curves function of temperature and Mg/Ca of water that depends on the [Mg] and [Ca] values in water and perhaps other factors. Our second example comes from sites near Valencia, Spain and involves shell data for ,Cyprideis torosa, an estuarine ostracode that is tolerant of a wide range of salinity and can live in continental waters as long as the carbonate alkalinity to Ca ratio is

  18. Is otolith microchemistry (Sr: Ca and Ba:Ca ratios useful to identify Mugil curema populations in the southeastern Caribbean Sea?

    Directory of Open Access Journals (Sweden)

    E. Avigliano

    Full Text Available Abstract The aim of the present study was to evaluate the potential use of otolith microchemistry (Sr:Ca and Ba:Ca ratios to identify silver mullet, Mugil curema, populations in Southeastern Caribbean Sea. Fish samples were collected in 7 areas of Nueva Esparta State (Venezuela. The otolith Sr:Ca and Ba:Ca ratios and water Sr:Ca were determined (by ICP-OES and EDTA volumetric method. Otoliths Sr:Ca and Ba:Ca ratios and Sr:Ca partition coefficient of mullets in Cubagua island (south of the State were significantly different from ratios in La Guardia (north of the State. A discriminant analysis of otolith Sr:Ca and Ba:Ca ratios separated Cubagua Island from La Guardia values. These results suggest the existence of different mullet groups in the Southeastern Caribbean Sea. For this, the simultaneous use of Sr:Ca and Ba:Ca ratios could be a potential tool to identify populations in the study area.

  19. Is otolith microchemistry (Sr: Ca and Ba:Ca ratios) useful to identify Mugil curema populations in the southeastern Caribbean Sea?

    Science.gov (United States)

    Avigliano, E; Callicó-Fortunato, R; Buitrago, J; Volpedo, A V

    2015-11-01

    The aim of the present study was to evaluate the potential use of otolith microchemistry (Sr:Ca and Ba:Ca ratios) to identify silver mullet, Mugil curema, populations in Southeastern Caribbean Sea. Fish samples were collected in 7 areas of Nueva Esparta State (Venezuela). The otolith Sr:Ca and Ba:Ca ratios and water Sr:Ca were determined (by ICP-OES and EDTA volumetric method). Otoliths Sr:Ca and Ba:Ca ratios and Sr:Ca partition coefficient of mullets in Cubagua island (south of the State) were significantly different from ratios in La Guardia (north of the State). A discriminant analysis of otolith Sr:Ca and Ba:Ca ratios separated Cubagua Island from La Guardia values. These results suggest the existence of different mullet groups in the Southeastern Caribbean Sea. For this, the simultaneous use of Sr:Ca and Ba:Ca ratios could be a potential tool to identify populations in the study area.

  20. Menstrual Cycle Dependent Variability for Serum Tumor Markers CEA, AFP, CA 19-9, CA 125 and CA 15-3 in Healthy Women

    Directory of Open Access Journals (Sweden)

    Ayşe Binnur Erbağci

    1999-01-01

    Full Text Available Information on menstrual cycle dependent variation of tumor markers in healthy women is a subject of diagnostic efficiency and has an impact in elucidating the normal function of these markers. In this study midfollicular and midluteal concentrations of serum CEA, AFP, CA 19-9, CA 125, CA 15-3 and their relations with LH, FSH, prolactin, estradiol and progesterone were evaluated during ovulatory cycles in a group of 23 healthy female individuals. Samples were collected on the 7th and 21st day of the same menstrual cycle. Tumor marker and hormone concentrations were determined with chemiluminescence or electrochemiluminescence EIA methods. A significant phase-dependent difference was observed for CA 15-3, midluteal concentrations (mean ± SEM; 26.33 ± 1.56 U/ml higher than the midfollicular (mean ± SEM; 19.27 ± 1.49 U/ml concentrations (p < 0.001. But an obvious difference for other tumor markers investigated did not exist. Significant correlations of follicular and luteal CA 125 levels with body mass index of the subjects were observed (r:0.52, p < 0.05 and r:0.57, p < 0.005, respectively.

  1. Ca(AlH4)2, CaAlH5, and CaH2+6LiBH4: Calculated dehydrogenation enthalpy, including zero point energy, and the structure of the phonon spectra.

    Science.gov (United States)

    Marashdeh, Ali; Frankcombe, Terry J

    2008-06-21

    The dehydrogenation enthalpies of Ca(AlH(4))(2), CaAlH(5), and CaH(2)+6LiBH(4) have been calculated using density functional theory calculations at the generalized gradient approximation level. Harmonic phonon zero point energy (ZPE) corrections have been included using Parlinski's direct method. The dehydrogenation of Ca(AlH(4))(2) is exothermic, indicating a metastable hydride. Calculations for CaAlH(5) including ZPE effects indicate that it is not stable enough for a hydrogen storage system operating near ambient conditions. The destabilized combination of LiBH(4) with CaH(2) is a promising system after ZPE-corrected enthalpy calculations. The calculations confirm that including ZPE effects in the harmonic approximation for the dehydrogenation of Ca(AlH(4))(2), CaAlH(5), and CaH(2)+6LiBH(4) has a significant effect on the calculated reaction enthalpy. The contribution of ZPE to the dehydrogenation enthalpies of Ca(AlH(4))(2) and CaAlH(5) calculated by the direct method phonon analysis was compared to that calculated by the frozen-phonon method. The crystal structure of CaAlH(5) is presented in the more useful standard setting of P2(1)c symmetry and the phonon density of states of CaAlH(5), significantly different to other common complex metal hydrides, is rationalized.

  2. Low temperature synthesis of CaZrO3 nanoceramics from CaCl2–NaCl molten eutectic salt

    Directory of Open Access Journals (Sweden)

    Rahman Fazli

    2015-06-01

    Full Text Available CaZrO3 nanoceramics were successfully synthesized at 700 C using the molten salt method, and the effects of processing parameters, such as temperature, holding time, and amount of salt on the crystallization of CaZrO3 were investigated. CaCl2, Na2CO3, and nano-ZrO2 were used as starting materials. On heating, CaCl2–NaCl molten eutectic salt provided a liquid medium for the reaction of CaCO3 and ZrO2 to form CaZrO3. The results demonstrated that CaZrO3 started to form at about 600C and that, after the temperature was increased to 1,000C, the amounts of CaZrO3 in the resultant powders increased with a concomitant decrease in CaCO3and ZrO2 contents. After washing with hot distilled water, the samples heated for 3 h at 700C were single-phase CaZrO3 with 90–95 nm particle size. Furthermore, the synthesized CaZrO3 particles retained the size and morphology of the ZrO2 powders which indicated that a template mechanism dominated the formation of CaZrO3 by molten-salt method.

  3. 16TH Annual Review of Progress in Applied Computational Electromagnetics at the Naval Postgraduate School Monterey, CA, March 20-24, 2000, Volume II

    Science.gov (United States)

    2000-03-24

    simplification neglects the transportation of heat radiation from one object to another and only the emission of heat from a surface. This becomes...P D - (1i 12) where -i j i(13) Oji =E 1 a, Fj, aj T4 where at, and &, are the absorption and emission coefficient of surface A , respectively...follows: _0 = GOt + hho (27) where h, 0 is nonzero eigenvector corresponding to zero eigenvalue, and h 0 is an arbitrary nonzero vector in space {h 1

  4. Ablation of CaV2.1 Voltage-Gated Ca2+ Channels in Mouse Forebrain Generates Multiple Cognitive Impairments

    Science.gov (United States)

    Mallmann, Robert Theodor; Elgueta, Claudio; Sleman, Faten; Castonguay, Jan; Wilmes, Thomas; van den Maagdenberg, Arn; Klugbauer, Norbert

    2013-01-01

    Voltage-gated CaV2.1 (P/Q-type) Ca2+ channels located at the presynaptic membrane are known to control a multitude of Ca2+-dependent cellular processes such as neurotransmitter release and synaptic plasticity. Our knowledge about their contributions to complex cognitive functions, however, is restricted by the limited adequacy of existing transgenic CaV2.1 mouse models. Global CaV2.1 knock-out mice lacking the α1 subunit Cacna1a gene product exhibit early postnatal lethality which makes them unsuitable to analyse the relevance of CaV2.1 Ca2+ channels for complex behaviour in adult mice. Consequently we established a forebrain specific CaV2.1 knock-out model by crossing mice with a floxed Cacna1a gene with mice expressing Cre-recombinase under the control of the NEX promoter. This novel mouse model enabled us to investigate the contribution of CaV2.1 to complex cognitive functions, particularly learning and memory. Electrophysiological analysis allowed us to test the specificity of our conditional knock-out model and revealed an impaired synaptic transmission at hippocampal glutamatergic synapses. At the behavioural level, the forebrain-specific CaV2.1 knock-out resulted in deficits in spatial learning and reference memory, reduced recognition memory, increased exploratory behaviour and a strong attenuation of circadian rhythmicity. In summary, we present a novel conditional CaV2.1 knock-out model that is most suitable for analysing the in vivo functions of CaV2.1 in the adult murine forebrain. PMID:24205277

  5. Capture reactions of 40Ca and 48Ca with targets of 197Au and 208Pb

    International Nuclear Information System (INIS)

    Stokstad, R.; Chan, Y.; Chavez, E.

    1988-03-01

    The reactions of 40 Ca and 48 Ca with targets of 197 Au and 208 Pb have been measured in the region from below the interaction barrier to about twice the barrier energy. The fission-like fragments were detected in a pair of position-sensitive, multi-wire proportional counters and were identified from measurements of position and time using two-body kinematics. In the region above the barrier the cross sections for capture are less than those given by the touching condition, indicating that an /open quotes/extra push/close quotes/ is required to induce capture. The observations for 40 Ca and 48 Ca show different fissilities for the onset of the extra push and indicate that charge equilibration may be an important factor governing capture reactions. Below the barrier the cross sections show an enhancement relative to the prediction for a one dimensional barrier. The enhancements are larger for 40 Ca than for 48 Ca (for both targets) and this is in qualitative agreement with predictions based on the coupling of the relative motion to low-lying collective states. Both above and below the barrier, we find that the change in the light partner, from 48 Ca to 40 Ca, has a larger effect on the cross sections than the change from 208 Pb to 197 Au, after correction for the change in the Coulomb barrier. 16 refs., 7 figs

  6. Walkability around primary schools and area deprivation across Scotland.

    Science.gov (United States)

    Macdonald, Laura; McCrorie, Paul; Nicholls, Natalie; Ellaway, Anne

    2016-04-14

    A number of studies based in the US, Canada, and Australia, have found evidence of associations between the built environment (BE) and mode of transport to school, and links between active travel and deprivation. Limited research in the UK compares potential BE supports for walking to school by area deprivation. Within this study, we gathered data on BE attributes previously linked to active travel, i.e., street/path connectivity, and dwelling density, created a composite 'walkability score' (WS) for areas around primary schools across urban Scotland, and explored whether poorer areas exhibit lower scores than more affluent areas, or vice versa. We consider this to be a novel approach as few studies have compared BE features by deprivation across a whole country. Address and road/path maps were obtained and primary schools (N = 937) across mainland Scotland were mapped. Schools were attributed income deprivation scores (scores divided into quintiles (Q1: least deprived, Q5: most deprived)). Catchment area (CA) boundaries, i.e., the geographic area representing eligibility for local school attendance, were drawn around schools, and WS calculated for each CA. We compared mean WS by income quintile (ANOVA), for all local authorities (LAs) combined (N = 29), and separately for the four LAs with the greatest number of schools included in the analysis. For all LAs combined, the least deprived quintile (Q1) showed a significantly lower WS (-0.61), than quintiles 3, 4 and 5 (Q2: -0.04 (non-sig), Q3: 0.38, Q4: 0.09, Q5: 0.18); while for Glasgow the second least deprived quintile (Q2) showed significantly higher WS (Q1: 1.35, Q2: 1.73), than middling (Q3: 0.18) and most deprived quintiles (Q4: 0.06, Q5: -0.10). WS differ by deprivation with patterns varying depending on the spatial scale of the analysis. It is essential that less walkable areas are provided with the resources to improve opportunities to engage in active travel.

  7. Formation Mechanism of CaS-Bearing Inclusions and the Rolling Deformation in Al-Killed, Low-Alloy Steel with Ca Treatment

    Science.gov (United States)

    Xu, Guang; Jiang, Zhouhua; Li, Yang

    2016-08-01

    The existing form of CaS inclusion in Ca-treated, Al-killed steel during secondary refining process was investigated with scanning electron microscopy and an energy-dispersive spectrometer (EDS). The results of 12 heats industrial tests showed that CaS has two kinds of precipitation forms. One form takes place by the direct reaction of Ca and S, and the other takes place by the reaction of CaO in calcium aluminates with dissolved Al and S in liquid steel. Thermodynamic research for different precipitation modes of CaS under different temperature was carried out. In particular, CaO-Al2O3-CaS isothermal section diagrams and component activities of calcium aluminates were calculated by the thermodynamic software FactSage. By thermodynamic calculation, a precipitation-area diagram of oxide-sulfide duplex inclusion was established by fixing the sulfur content. The quantity of CaS, which was precipitated in a reaction between [Al], [S] and (CaO), can be calculated and predicted based on the precipitation-area diagram of oxide-sulfide duplex inclusion. Electron probe microanalysis and EDS were used for observing rolling deformation of different types of CaS-bearing inclusions during the rolling process. Low modification of calcium aluminates wrapped by CaS has different degrees of harm to steel in the rolling process. A thick CaS layer can prevent some fragile calcium aluminates from being crushed during the rolling process. Some oxide-sulfide duplex inclusion contains little CaS performed better deformation during the rolling process, but when CaS in oxide-sulfide duplex inclusion becomes more, it will cause the whole inclusion to lose plastic yielding ability. The plastic deformation region of CaS-bearing inclusion in a CaO-Al2O3-CaS isothermal section diagram is confirmed.

  8. Solidification and Immobilization of Heavy metals in Soil using with nano-metallic Ca/CaO Dispersion Mixture

    Directory of Open Access Journals (Sweden)

    Mallampati S. R.

    2013-04-01

    Full Text Available In the present work, the use of nano-metallic calcium (Ca and calcium oxide (CaO dispersion mixture for the immobilization of heavy metals (As, Cd, Cr and Pb in soil was investigated. With simple grinding, 85-90% of heavy metals immobilization could be achieved, while it could be enhanced to 98-100% by grinding with the addition of nano-metallic Ca/CaO dispersion mixture. By SEM-EDS elemental maps as well as semi-quantitative analysis observed that the amount of As, Cd, Cr and Pb measurable on soil particle surface decreases after nano-metallic Ca/CaO treatment. The leachable heavy metals concentrations were reduced, to the concentration lower than the Japan soil elution standard regulatory threshold, i. e., < 0.01 mg/l for As, Cd and Pb and 0.05mg/l for Cr. Whereas, the effect of soil moisture and pH on heavy metals immobilization was not much influenced. The results suggest that nano-metallic Ca/CaO mixture is suitable to be used for the gentle immobilization of heavy metals contaminated soil at normal moisture conditions.

  9. Mechanical and thermal-expansion characteristics of Ca10(PO46(OH2-Ca3(PO42 composites

    Directory of Open Access Journals (Sweden)

    Ruseska G.

    2006-01-01

    Full Text Available Three types of composites consisting of Ca10(PO46(OH2 and Ca3(PO42 with composition: 75% (wt Ca10(PO46(OH2: 25%(wt Ca3(PO42; 50%(wt Ca10(PO46(OH2: 50%(wtCa3(PO42 and 25 %(wt Ca10(PO46(OH2: 75%(wt Ca3(PO42 were the subject of our investigation. Sintered compacts were in thermal equilibrium, which was proved by the absence of hysteresis effect of the dependence ΔL/L=f(T during heating /cooling in the temperature interval 20-1000-200C. Sintered compacts with the previously mentioned composition possess 26-50% higher values of the E-modulus, G-modulus and K-modulus indicating the presence of a synergism effect. Several proposed model equations for predicting the thermal expansion coefficient in dependence of the thermal and elastic properties of the constitutive phases and their volume fractions, given by: Turner, Kerner, Tummala and Friedberg, Thomas and Taya, were used for making correlations between mechanical and thermal-expansion characteristics of the Ca10(PO46(OH2 - Ca3(PO42 composites. Application of the previously mentioned model equations to all kinds of composites leads to the conclusion that the experimentally obtained results for the thermal expansion coefficient are in an excellent agreement with the theoretical calculated values on account of the volume fraction of each constitutive phase and with all applied model equations, with a coefficient of correlation from 98.16-99.86 %.

  10. Regional and interspecific variation in Sr, Ca, and Sr/Ca ratios in avian eggshells from the USA.

    Science.gov (United States)

    Mora, Miguel A; Brattin, Bryan; Baxter, Catherine; Rivers, James W

    2011-08-01

    To examine regional variation in strontium (Sr), which at high concentrations may reduce eggshell quality, increase egg breakage and reproductive failure, we analyzed Sr, and calcium (Ca) concentrations and Sr/Ca ratios in eggshells from 20 avian species from California, Texas, Idaho, Kansas, and Michigan. In addition, we included data previously reported from Arizona to expand the regional comparisons and to better establish patterns of Sr, and Sr/Ca ratios in bird species across the United States. We found Sr concentrations varied significantly among regions, among species, and among foraging guilds; this variability is strongly influenced by the Sr/Ca ratios in surface water from locations close to the region where the eggshells were collected. Sr concentrations and Sr/Ca ratios were significantly higher in bird eggshells from the Volta wildlife region in the San Joaquin Valley, California and in various locales from Arizona. Sr concentrations and Sr/Ca ratios in bird eggshells from other locations in the USA were lower than those detected in these two regions. Among foraging guilds, invertivores had the highest Sr concentrations and Sr/Ca ratios and carnivores had the lowest. In general, the Sr/Ca ratio increased strongly with increasing Sr concentrations (R(2) = 0.99, P eggshells suggesting that these values could be determined from Sr/Ca ratios in water. Eggshell thickness was poorly correlated with Sr (R(2) = 0.03) but had a significant and positive correlation with Ca and was more properly correlated by a quadratic equation (R(2) = 0.50, Thickness = 2.13 - 0.02Ca - 3.07 * 10(-5)Ca(2)). Our study provides further evidence that Sr accumulates significantly in the avian eggshell, in some regions at concentrations which could be of concern for potential negative effects on reproduction. We suggest that when assessing the effects of metals on avian reproduction in regions with high Sr deposits in rock and soil, Sr concentrations in the eggshell also should be

  11. Cannabinoids disrupt memory encoding by functionally isolating hippocampal CA1 from CA3.

    Directory of Open Access Journals (Sweden)

    Roman A Sandler

    2017-07-01

    Full Text Available Much of the research on cannabinoids (CBs has focused on their effects at the molecular and synaptic level. However, the effects of CBs on the dynamics of neural circuits remains poorly understood. This study aims to disentangle the effects of CBs on the functional dynamics of the hippocampal Schaffer collateral synapse by using data-driven nonparametric modeling. Multi-unit activity was recorded from rats doing an working memory task in control sessions and under the influence of exogenously administered tetrahydrocannabinol (THC, the primary CB found in marijuana. It was found that THC left firing rate unaltered and only slightly reduced theta oscillations. Multivariate autoregressive models, estimated from spontaneous spiking activity, were then used to describe the dynamical transformation from CA3 to CA1. They revealed that THC served to functionally isolate CA1 from CA3 by reducing feedforward excitation and theta information flow. The functional isolation was compensated by increased feedback excitation within CA1, thus leading to unaltered firing rates. Finally, both of these effects were shown to be correlated with memory impairments in the working memory task. By elucidating the circuit mechanisms of CBs, these results help close the gap in knowledge between the cellular and behavioral effects of CBs.

  12. A dynamic model of interactions of Ca2+, calmodulin, and catalytic subunits of Ca2+/calmodulin-dependent protein kinase II.

    Directory of Open Access Journals (Sweden)

    Shirley Pepke

    2010-02-01

    Full Text Available During the acquisition of memories, influx of Ca2+ into the postsynaptic spine through the pores of activated N-methyl-D-aspartate-type glutamate receptors triggers processes that change the strength of excitatory synapses. The pattern of Ca2+influx during the first few seconds of activity is interpreted within the Ca2+-dependent signaling network such that synaptic strength is eventually either potentiated or depressed. Many of the critical signaling enzymes that control synaptic plasticity,including Ca2+/calmodulin-dependent protein kinase II (CaMKII, are regulated by calmodulin, a small protein that can bindup to 4 Ca2+ ions. As a first step toward clarifying how the Ca2+-signaling network decides between potentiation or depression, we have created a kinetic model of the interactions of Ca2+, calmodulin, and CaMKII that represents our best understanding of the dynamics of these interactions under conditions that resemble those in a postsynaptic spine. We constrained parameters of the model from data in the literature, or from our own measurements, and then predicted time courses of activation and autophosphorylation of CaMKII under a variety of conditions. Simulations showed that species of calmodulin with fewer than four bound Ca2+ play a significant role in activation of CaMKII in the physiological regime,supporting the notion that processing of Ca2+ signals in a spine involves competition among target enzymes for binding to unsaturated species of CaM in an environment in which the concentration of Ca2+ is fluctuating rapidly. Indeed, we showed that dependence of activation on the frequency of Ca2+ transients arises from the kinetics of interaction of fluctuating Ca2+with calmodulin/CaMKII complexes. We used parameter sensitivity analysis to identify which parameters will be most beneficial to measure more carefully to improve the accuracy of predictions. This model provides a quantitative base from which to build more complex dynamic

  13. Significance of the tumor markers CA 125 and CA 15-3 in postoperative diagnosis of ovarian and breast cancer

    International Nuclear Information System (INIS)

    Johannsen, B.; Bartel, U.; Elling, D.

    1989-01-01

    In 271 patients with ovarian carcinoma, benign ovarian tumors, breast cancer, and two control groups, serum levels of CA 125, CA 15-3, CEA and, partly, CA 19-9 were determined immunoradiometrically. According to the results of the determination of CA 125 in the follow-up of ovarian carcinoma, CA 125 represents a useful marker for early detection of recurrences, especially in cases of diffuse carcinoma dissemination. In incomplete tumor debulking, postoperative CA 125 serum levels did not prove to be helpful except that a positive level renders invasive diagnostic investigation no longer necessary. Postoperative follow-up in breast cancer early reveals distant metastases, with very high levels in patients with bone metastases. By simultaneous measurement of CA 15-3 and CEA the sensitivity could be increased from 86% (CA 15-3 only) to 93%. (author)

  14. Multiple Ca2+ sensors in secretion

    DEFF Research Database (Denmark)

    Walter, Alexander M; Groffen, Alexander J; Sørensen, Jakob Balslev

    2011-01-01

    Regulated neurotransmitter secretion depends on Ca(2+) sensors, C2 domain proteins that associate with phospholipids and soluble N-ethylmaleimide-sensitive fusion attachment protein receptor (SNARE) complexes to trigger release upon Ca(2+) binding. Ca(2+) sensors are thought to prevent spontaneous...

  15. Ion microprobe assessment of the heterogeneity of Mg/Ca, Sr/Ca and Mn/Ca ratios in Pecten maximus and Mytilus edulis (bivalvia shell calcite precipitated at constant temperature

    Directory of Open Access Journals (Sweden)

    P. S. Freitas

    2009-07-01

    Full Text Available Small-scale heterogeneity of biogenic carbonate elemental composition can be a significant source of error in the accurate use of element/Ca ratios as geochemical proxies. In this study ion microprobe (SIMS profiles showed significant small-scale variability of Mg/Ca, Sr/Ca and Mn/Ca ratios in new shell calcite of the marine bivalves Pecten maximus and Mytilus edulis that was precipitated during a constant-temperature culturing experiment. Elevated Mg/Ca, Sr/Ca and Mn/Ca ratios were found to be associated with the deposition of elaborate shell features, i.e. a shell surface stria in P. maximus and surface shell disturbance marks in both species, the latter a common occurrence in bivalve shells. In both species the observed small-scale elemental heterogeneity most likely was not controlled by variable transport of ions to the extra-pallial fluid, but by factors such as the influence of shell organic content and/or crystal size and orientation, the latter reflecting conditions at the shell crystal-solution interface. In the mid and innermost regions of the P. maximus shell the lack of significant small-scale variation of Mg/Ca ratios, which is consistent with growth at constant temperature, suggest a potential application as a palaeotemperature proxy. Cross-growth band element/Ca ratio profiles in the interior of bivalve shells may provide more promising palaeo-environmental tools than sampling from the outer region of bivalve shells.

  16. Computerized Project Management: How to Use a Macintosh to Improve Manager Productivity.

    Science.gov (United States)

    1986-03-01

    similiar in concept to the "Flat Rate Manual" automobile shops use when repairing a car. That book lists all parts and the standard time necessary to do a...word processing document. Such a system would be similar to the ’flat rate manual’ used in automobile repair shops that list resource and time...Monterey, CA 93943 6. Commandant (G-TPP/ HRM )1 U.S. Coast Guard 2 100 Second St SW Washington, DC 20953 7. Cdr John Stumpf f 1 CCGD Eleven (dpi) 400

  17. Clinical value of multi-tumor markers detection with (CEA, CA19-9, CA72-4) for diagnosis of gastric malignancy

    International Nuclear Information System (INIS)

    Liu Yun; Li Jiangang

    2007-01-01

    Objective: To assess the clinical value of multi-tumor markers detection with (CEA, CA19-9, CA72-4) for diagnosis of gastric malignancy. Methods: Serum CEA, CA19-9, CA72-4 contents were measured with IRMA in 228 patients with gastric malignancies, 152 patients with benign gastric disorders and 200 controls. Results: The positive rates of single marker detection were all above 70% and that of CA72-4 was the highest (84.21%), next was CA19-9 (75.43%). Three tumor markers were all negative in only 4 cases (false negative rate was 1.75% ). So combined detection of 3 tumor markers could improve the positive rate to 98.25%. With combined determination of two markers, double positive rate for different sets of combinations was: 61.84% for CA72-4 + CA19-9, 51.31% for CA72-4 + CEA and 48.24% for CEA + CA19-9. Conclusion: It was suggested that for screening, CA72-4 was the first choice in single marker detections, and CA72-4 + CA19-9 was the first choice for combined detections of two markers. For follow-up, a combination of 2 markers with highest positive rate for the specific histopathologic type (i. e. carcinoma, leiomyosarcoma or lymphosarcoma) should be used throughout the study. (authors)

  18. CaMKII in sinoatrial node physiology and dysfunction

    Directory of Open Access Journals (Sweden)

    Yuejin eWu

    2014-03-01

    Full Text Available The calcium and calmodulin dependent protein kinase II (CaMKII is present in sinoatrial node (SAN pacemaker cells and is required for physiological fight or flight SAN beating rate responses. Inhibition of CaMKII in SAN does not affect baseline heart rate, but reduces heart rate increases in response to physiological stress. CaMKII senses intracellular calcium (Ca2+ changes, oxidation status and hyperglycemia to phosphorylate substrates that regulate Ca2+-sensitive proteins, such as L-type Ca2+ channels, phospholamban (PLN, and cardiac ryanodine receptors (RyR2. All of these substrates are involved in the SAN pacemaking mechanism. Excessive CaMKII activity, as occurs under pathological conditions such as heart failure, ischemia and diabetes, can promote intracellular Ca2+ overload and reactive oxygen species (ROS production. Oxidation of CaMKII (ox-CaMKII locks CaMKII into a constitutively active configuration that contributes to SAN cell apoptosis and fibrosis. This ox-CaMKII-mediated loss of functional SAN cells contributes to sinoatrial node dysfunction (SND and sudden death. Thus, CaMKII has emerged as a central regulator of physiological SAN responses and a key determinant of SND.

  19. CaMKII in the Cardiovascular System: Sensing Redox States

    Science.gov (United States)

    Erickson, Jeffrey R.; He, B. Julie; Grumbach, Isabella M.; Anderson, Mark E

    2013-01-01

    The multifunctional Ca2+ and calmodulin-dependent protein kinase II (CaMKII) is now recognized to play a central role in pathological events in the cardiovascular system. CaMKII has diverse downstream targets that promote vascular disease, heart failure and arrhythmias, so improved understanding of CaMKII signaling has the potential to lead to new therapies for cardiovascular disease. CaMKII is a multimeric serine-threonine kinase that is initially activated by binding calcified calmodulin (Ca2+/CaM). Under conditions of sustained exposure to elevated Ca2+/CaM CaMKII transitions into a Ca2+/CaM-autonomous enzyme by two distinct but parallel processes. Autophosphorylation of threonine 287 in the CaMKII regulatory domain ‘traps’ CaMKII into an open configuration even after Ca2+/CaM unbinding. More recently, our group identified a pair of methionines (281/282) in the CaMKII regulatory domain that undergo a partially reversible oxidation which, like autophosphorylation, prevents CaMKII from inactivating after Ca2+/CaM unbinding. Here we review roles of CaMKII in cardiovascular disease with an eye to understanding how CaMKII may act as a transduction signal to connect pro-oxidant conditions into specific downstream pathological effects that are relevant to rare and common forms of cardiovascular disease. PMID:21742790

  20. Determination of Mo- and Ca-isotope ratios in Ca100MoO4 crystal for AMoRE-I experiment

    Science.gov (United States)

    Karki, S.; Aryal, P.; Kim, H. J.; Kim, Y. D.; Park, H. K.

    2018-01-01

    The first phase of the AMoRE (Advanced Mo-based Rare process Experiment) is to search for neutrinoless double-beta decay of 100Mo with calcium molybdate (Ca100MoO4) crystals enriched in 100Mo and depleted in 48Ca using a cryogenic technique at Yangyang underground laboratory in Korea. It is important to know 100Mo- and 48Ca-isotope ratios in Ca100MoO4 crystal to estimate half-life of 100Mo decays and to 2 νββ background from 48Ca. We employed the ICP-MS (Inductive Coupled Plasma Mass Spectrometer) to measure 100Mo- and 48Ca-isotope ratios in Ca100MoO4 crystal. The measured results for 100Mo- and 48Ca-isotope ratios in the crystal are (94 . 6 ± 2 . 8) % and (0 . 00211 ± 0 . 00006) %, respectively, where errors are included both statistical and systematic uncertainties.

  1. The destiny of Ca(2+) released by mitochondria.

    Science.gov (United States)

    Takeuchi, Ayako; Kim, Bongju; Matsuoka, Satoshi

    2015-01-01

    Mitochondrial Ca(2+) is known to regulate diverse cellular functions, for example energy production and cell death, by modulating mitochondrial dehydrogenases, inducing production of reactive oxygen species, and opening mitochondrial permeability transition pores. In addition to the action of Ca(2+) within mitochondria, Ca(2+) released from mitochondria is also important in a variety of cellular functions. In the last 5 years, the molecules responsible for mitochondrial Ca(2+) dynamics have been identified: a mitochondrial Ca(2+) uniporter (MCU), a mitochondrial Na(+)-Ca(2+) exchanger (NCLX), and a candidate for a mitochondrial H(+)-Ca(2+) exchanger (Letm1). In this review, we focus on the mitochondrial Ca(2+) release system, and discuss its physiological and pathophysiological significance. Accumulating evidence suggests that the mitochondrial Ca(2+) release system is not only crucial in maintaining mitochondrial Ca(2+) homeostasis but also participates in the Ca(2+) crosstalk between mitochondria and the plasma membrane and between mitochondria and the endoplasmic/sarcoplasmic reticulum.

  2. Cavity Ring-Down Measurement of Aerosol Optical Properties During the Asian Dust Above Monterey Experiment and DOE Aerosol Intensive Operating Period

    Science.gov (United States)

    Ricci, K.; Strawa, A. W.; Provencal, R.; Castaneda, R.; Bucholtz, A.; Schmid, B.

    2004-01-01

    Large uncertainties in the effects of aerosols on climate require improved in-situ measurements of extinction coefficient and single-scattering albedo. This paper describes preliminary results from Cadenza, a new continuous wave cavity ring-down (CW-CRD) instrument designed to address these uncertainties. Cadenza measures the aerosol extinction coefficient for 675 nm and 1550 nm light, and simultaneously measures the scattering coefficient at 675 nm. In the past year Cadenza was deployed in the Asian Dust Above Monterey (ADAM) and DOE Aerosol Intensive Operating Period (IOP) field projects. During these flights Cadenza produced measurements of aerosol extinction in the range from 0.2 to 300/Mm with an estimated precision of 0.1/Mm for 1550 nm light and 0.2/Mm for 675 nm light. Cadenza data from the ADAM and Aerosol IOP missions compared favorably with data from the other instruments aboard the CIRPAS Twin Otter aircraft and participating in those projects. We present comparisons between the Cadenza measurements and those from a TSI nephelometer, Particle Soot Absorption Photometer (PSAP), and the AATS 14 sun-photometer. Measurements of the optical properties of smoke and dust plumes sampled during these campaigns are presented and estimates of heating rates due to these plumes are made.

  3. Eating School Lunch Is Associated with Higher Diet Quality among Elementary School Students.

    Science.gov (United States)

    Au, Lauren E; Rosen, Nila J; Fenton, Keenan; Hecht, Kenneth; Ritchie, Lorrene D

    2016-11-01

    Few studies have assessed the dietary quality of children who eat meals from home compared with school meals according to the 2010 Dietary Guidelines for Americans. The objective of this study was to examine diet quality for elementary school students in relation to source of breakfast and lunch (whether school meal or from an outside source). An observational study was conducted of students in 43 schools in San Diego, CA, during the 2011-2012 school year. Fourth- and fifth-grade students (N=3,944) completed a diary-assisted 24-hour food recall. The Healthy Eating Index-2010 (HEI-2010) scores of children who ate breakfast and lunch at school were compared with the HEI-2010 scores of children who obtained their meals from home and a combination of both school and home. Analysis of variance, χ 2 test, and generalized estimating equation models adjusted for age, sex, race/ethnicity, grade, language, and school level clustering were performed. School lunch eaters had a higher mean±standard deviation overall diet quality score (HEI-2010=49.0±11.3) compared with students who ate a lunch obtained from home (46.1±12.2; P=0.02). There was no difference in overall diet quality score by breakfast groups. Students who ate school breakfast had higher total fruit (P=0.01) and whole fruit (P=0.0008) scores compared with students who only ate breakfast obtained from home. Students who ate school foods had higher scores for dairy (P=0.007 for breakfast and Pempty calories from solid fats and added sugars (P=0.01 for breakfast and P=0.007 for lunch). Eating school lunch was associated with higher overall diet quality compared with obtaining lunch from home. Future studies are needed that assess the influence of the Healthy Hunger-Free Kids Act on children's diet quality. Copyright © 2016 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

  4. I. The properties of hot Ca-like fragments from the 40Ca+40Ca reaction at 35 AMeV

    International Nuclear Information System (INIS)

    Planeta, R.; Gawlikowicz, W.; Wieloch, A.

    2001-01-01

    The creation of hot Ca-like fragments was investigated in the 40 Ca + 40 Ca reaction at 35 AMeV. Using the AMPHORA 4π detector system, the primary projectile-like fragment was reconstructed and its properties were determined. Both primary and secondary distributions are compared with the predictions of a Monte Carlo code describing a heavy-ion collision as a two-step process. Some of the nucleons which are identified as participants in the first step are transferred in the second step to these final states, which correspond on the average to the maximum value of entropy (thermodynamic probability). The model allows for competition between mean-field effects and nucleon-nucleon interactions in the overlap zone of the interacting nuclei. The analysis presented here suggests a thermalized source picture of the decay of the projectile-like fragment. The validity of the reconstruction procedure for projectile-like fragments is discussed. (orig.)

  5. Reassigning the CaH+ 11Σ → 21Σ vibronic transition with CaD+

    Science.gov (United States)

    Condoluci, J.; Janardan, S.; Calvin, A. T.; Rugango, R.; Shu, G.; Sherrill, C. D.; Brown, K. R.

    2017-12-01

    We observe vibronic transitions in CaD+ between the 11Σ and 21Σ electronic states by resonance enhanced multiphoton photodissociation spectroscopy in a Coulomb crystal. The vibronic transitions are compared with previous measurements on CaH+. The result is a revised assignment of the CaH+ vibronic levels and a disagreement with multi-state-complete-active-space second-order perturbation theory theoretical calculations by approximately 700 cm-1. Updated high-level coupled-cluster calculations that include core-valence correlations reduce the disagreement between theory and experiment to 300 cm-1.

  6. Integration of adaptive optics into highEnergy laser modeling and simulation

    Science.gov (United States)

    2017-06-01

    contain hundreds of actuators with high control bandwidths and low hysteresis, all of which are ideal parameters for accurate reconstruction of higher... Available : https://web.archive.org/web/20110111093235/http: //csis.org/blog/missile-defense-umbrella [10] C. Kopp, “ High energy laser directed energy...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS INTEGRATION OF ADAPTIVE OPTICS INTO HIGH ENERGY LASER MODELING AND SIMULATION by Donald Puent

  7. Prediction Markets as a Way to Manage Acquisition Programs

    Science.gov (United States)

    2011-06-01

    volume helps management set production levels, but if management increases advertising it will undermine the market . This becomes critical for the DoD...34 Corporate Strategy Board. Gaspoz, C. (2008). "Prediction markets as an innovative way to manage R&D portfolios." CAiSE Doctoral Consortium. Montpellier...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT Prediction Markets as a Way to Manage Acquisition

  8. A Model for Real-Time Data Reputation Via Cyber Telemetry

    Science.gov (United States)

    2016-06-01

    methodology which focuses on iterative cycles, known as sprints, to produce the capabilities of the system. Traditional waterfall models do not allow for...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited A MODEL FOR REAL...Master’s Thesis 4. TITLE AND SUBTITLE A MODEL FOR REAL-TIME DATA REPUTATION VIA CYBER TELEMETRY 5. FUNDING NUMBERS 6. AUTHOR(S) Beau M

  9. Empirical Analysis of Using Erasure Coding in Outsourcing Data Storage With Provable Security

    Science.gov (United States)

    2016-06-01

    computing and communication technologies become powerful and advanced , people are exchanging a huge amount of data, and they are de- manding more storage...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS EMPIRICAL ANALYSIS OF USING ERASURE CODING IN OUTSOURCING DATA STORAGEWITH PROVABLE SECURITY by...2015 to 06-17-2016 4. TITLE AND SUBTITLE EMPIRICAL ANALYSIS OF USING ERASURE CODING IN OUTSOURCING DATA STORAGE WITH PROVABLE SECURITY 5. FUNDING

  10. Feasibility of High Energy Lasers for Interdiction Activities

    Science.gov (United States)

    2017-12-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS FEASIBILITY OF HIGH ENERGY LASERS FOR INTERDICTION ACTIVITIES by Carlos Abel Javier Romero... ENERGY LASERS FOR INTERDICTION ACTIVITIES 5. FUNDING NUMBERS 6. AUTHOR(S) Carlos Abel Javier Romero Chero 7. PERFORMING ORGANIZATION NAME(S) AND...the people or cargo. High Energy Laser (HEL) weapons are an effective way to deliver energy precisely from a relative long range. This thesis studies

  11. Reduction Expansion Synthesis for Magnetic Alloy Powders

    Science.gov (United States)

    2015-12-01

    in Figure 1, the Army was able to address its need for printable plastic components, thus enabling a reduction in the total quantity of spare...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited REDUCTION EXPANSION SYNTHESIS FOR...Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202–4302, and to the Office of Management and Budget, Paperwork Reduction Project

  12. An End to the Troubles: Unionism, Nationalism and the Path to Peace

    Science.gov (United States)

    2006-12-01

    Nationalist community but also provided a viable alternative to the violence espoused by the PIRA.14 The policy of abstentionism was not without risk...revolutionary socialism; and the continuation of the policy of abstentionism was hindering the party’s ability to achieve political change on its terms...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release: distribution is unlimited AN END TO THE

  13. Greek-Turkish Crises since 1955. Implications for Greek-Turkish Conflict Management

    Science.gov (United States)

    1997-03-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS GREEK-TURKISH CRISES SINCE 1955. IMPLICATIONS FOR GREEK-TURKISH CONFLICT MANAGEMENT by...EU, WEU) have only to gain from a Greek-Turkish rapprochement. 14. SUBJECT TERMS GrEek-Turkish RElATiONS, CRiSiS MANAgEMENT, CONfLICT management 15...crises, because the intended outcome of mediation attempts has been regional stability instead of Greek-Turkish conflict management . Power mediation

  14. Denying the Dangerous: Preventing Firearms from Entering the Hands of the Dangerously Mentally Ill

    Science.gov (United States)

    2014-12-01

    Criminal Records Exchange CLEO Chief Law Enforcement Officer CMHS Center for Multicultural Human Services CSB Community Services Board DENI...activities. In July 1997, Cho’s parents took him to the Center for Multicultural Human Services (CMHS), a mental health facility for low income, English...DISTRIBUTION LIST 1. Defense Technical Information Center Ft. Belvoir, Virginia 2. Dudley Knox Library Naval Postgraduate School Monterey, California 81

  15. Managing the Transformation: A Change Management Strategy for U.S. Marine Corps Expeditionary Energy Initiatives

    Science.gov (United States)

    2017-12-01

    sensegiving in transformational change processes from the bottom up. Higher Education , 65(6), 761–780. doi:10.1007/s10734-012-9575-7 Kezar, A...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. MANAGING THE TRANSFORMATION : A...DATE December 2017 3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE MANAGING THE TRANSFORMATION : A CHANGE MANAGEMENT STRATEGY

  16. Information Technology (IT) Ethics: Training and Awareness Materials for the Department of the Navy

    Science.gov (United States)

    2002-06-01

    people in DoD. Although every effort is taken to prevent it, the fact remains that computers and information technology create ethical issues that...illegal activity of this type takes place. 3. Collection, Stewardship, and Use of Information In this era of computer networks and the Internet ...NAVAL POSTGRADUATE SCHOOL Monterey, California THESIS Approved for public release; distribution is unlimited INFORMATION TECHNOLOGY (IT) ETHICS

  17. Reduction Expansion Synthesis of Chromium and Nickel Metal Coatings

    Science.gov (United States)

    2017-06-01

    Garth V. Hobson Chair, Department of Mechanical and Aerospace Engineering iv THIS PAGE INTENTIONALLY LEFT BLANK v ABSTRACT This thesis represents a...chromium and nickel coatings,” Plating and Surface Finishing, vol. 92, no. 4, pp. 42–48, Apr. 2005. [43] S. I. Sandler, Chemical and Engineering ...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. REDUCTION EXPANSION SYNTHESIS OF

  18. IP Infrastructure Geolocation

    Science.gov (United States)

    2015-03-01

    by non-commercial enti- ties. HostiP is a community-driven geolocation service. It provides an Application Pro- gramming Interface ( API ) for...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS IP INFRASTRUCTURE GEOLOCATION Thesis Advisor: Second Reader: by Guan Yan Cai March...FUNDING NUMBERS IP INFRASTRUCfURE GEOLOCATION N66001-2250-59231 6. AUTHOR(S) Guan Yan Cai 7. PERFORMING ORGANIZATION NAME(S) AND AOORESS(ES) 9

  19. Model for Atmospheric Propagation of Spatially Combined Laser Beams

    Science.gov (United States)

    2016-09-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS MODEL FOR ATMOSPHERIC PROPAGATION OF SPATIALLY COMBINED LASER BEAMS by Kum Leong Lee September...MODEL FOR ATMOSPHERIC PROPAGATION OF SPATIALLY COMBINED LASER BEAMS 5. FUNDING NUMBERS 6. AUTHOR(S) Kum Leong Lee 7. PERFORMING ORGANIZATION NAME(S) AND...BLANK ii Approved for public release. Distribution is unlimited. MODEL FOR ATMOSPHERIC PROPAGATION OF SPATIALLY COMBINED LASER BEAMS Kum Leong Lee

  20. Analysis And Augmentation Of Timing Advance Based Geolocation In Lte Cellular Networks

    Science.gov (United States)

    2016-12-01

    measurements to validate TA-based positioning approaches in LTE . Their approach did not, however, focus on characterizing the TA. Rather, similar to...UE will measure the time difference of arrival of the LTE Positioning Reference Signal (PRS) from multiple eNBs. This information is then sent to a...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA DISSERTATION ANALYSIS AND AUGMENTATION OF TIMING ADVANCE-BASED GEOLOCATION IN LTE CELLULAR NETWORKS by

  1. Clinical Significance and Prognostic Value of CA72-4 Compared with CEA and CA19-9 in Patients with Gastric Cancer

    Directory of Open Access Journals (Sweden)

    M. Ychou

    2000-01-01

    Full Text Available Carcinoembryonic antigen (CEA and CA 19-9 are both widely used in the follow up of patients with gastrointestinal cancer. More recently another tumor marker, named CA 72-4 has been identified and characterized using two different monoclonal antibodies B72.3 and CC49. Several reports evaluated CA 72-4 as a serum tumor marker for gastric cancer and compared its clinical utility with that of CEA or CA 19-9; few reports concerned its prognostic value. In the present study, CA 72-4 is evaluated and compared with CEA and CA 19-9 in various populations of patients with gastric cancer and benign disease; for 52 patients with gastric adenocarcinoma and 57 patients without neoplastic disease CEA, CA 19-9 and CA 72-4 were evaluated before treatment. Sensitivity of the tumor markers CA 72-4, CA 19-9 and CEA at the recommended cut-off level in all 52 patients were 58%, 50% the sensitivity increased to 75%. of these markers, for non metastatic patients, multivariate analyses indicated that none of the markers were significant, when adjusted for gender and age (which were indicators of poor prognosis; patients with abnormal values of CA72-4 tended to have shorter survival than patients with normal values (p < 0.07. In the metastatic population, only high values of CA19-9 (p < 0.02 and gender (women (p < 0.03 were indicators of poor prognosis in univariate analysis; multivariate analysis revealed that both CA72-4 (p = 0.034 and CA19-9 p = 0.009, adjusted for gender were independent prognostic factors. However, CA72-4 lost significance (p = 0.41 when adjusted for CA19-9 and gender, indicating that CA19-9 provides more prognostic information than CA72-4.

  2. Semantic web data warehousing for caGrid.

    Science.gov (United States)

    McCusker, James P; Phillips, Joshua A; González Beltrán, Alejandra; Finkelstein, Anthony; Krauthammer, Michael

    2009-10-01

    The National Cancer Institute (NCI) is developing caGrid as a means for sharing cancer-related data and services. As more data sets become available on caGrid, we need effective ways of accessing and integrating this information. Although the data models exposed on caGrid are semantically well annotated, it is currently up to the caGrid client to infer relationships between the different models and their classes. In this paper, we present a Semantic Web-based data warehouse (Corvus) for creating relationships among caGrid models. This is accomplished through the transformation of semantically-annotated caBIG Unified Modeling Language (UML) information models into Web Ontology Language (OWL) ontologies that preserve those semantics. We demonstrate the validity of the approach by Semantic Extraction, Transformation and Loading (SETL) of data from two caGrid data sources, caTissue and caArray, as well as alignment and query of those sources in Corvus. We argue that semantic integration is necessary for integration of data from distributed web services and that Corvus is a useful way of accomplishing this. Our approach is generalizable and of broad utility to researchers facing similar integration challenges.

  3. CaV1.3 L-type Ca2+ channels modulate depression-like behaviour in mice independent of deaf phenotype.

    Science.gov (United States)

    Busquet, Perrine; Nguyen, Ngoc Khoi; Schmid, Eduard; Tanimoto, Naoyuki; Seeliger, Mathias W; Ben-Yosef, Tamar; Mizuno, Fengxia; Akopian, Abram; Striessnig, Jörg; Singewald, Nicolas

    2010-05-01

    Mounting evidence suggests that voltage-gated L-type Ca2+ channels can modulate affective behaviour. We therefore explored the role of CaV1.3 L-type Ca2+ channels in depression- and anxiety-like behaviours using CaV1.3-deficient mice (CaV1.3-/-). We showed that CaV1.3-/- mice displayed less immobility in the forced swim test as well as in the tail suspension test, indicating an antidepressant-like phenotype. Locomotor activity in the home cage or a novel open-field test was not influenced. In the elevated plus maze (EPM), CaV1.3-/- mice entered the open arms more frequently and spent more time there indicating an anxiolytic-like phenotype which was, however, not supported in the stress-induced hyperthermia test. By performing parallel experiments in Claudin 14 knockout mice (Cldn14-/-), which like CaV1.3-/- mice are congenitally deaf, an influence of deafness on the antidepressant-like phenotype could be ruled out. On the other hand, a similar EPM behaviour indicative of an anxiolytic phenotype was also found in the Cldn14-/- animals. Using electroretinography and visual behavioural tasks we demonstrated that at least in mice, CaV1.3 channels do not significantly contribute to visual function. However, marked morphological changes were revealed in synaptic ribbons in the outer plexiform layer of CaV1.3-/- retinas by immunohistochemistry suggesting a possible role of this channel type in structural plasticity at the ribbon synapse. Taken together, our findings indicate that CaV1.3 L-type Ca2+ channels modulate depression-like behaviour but are not essential for visual function. The findings raise the possibility that selective modulation of CaV1.3 channels could be a promising new therapeutic concept for the treatment of mood disorders.

  4. Use of the "gl1" Mutant and the "CA-rop2" Transgenic Plants of "Arabidopsis thaliana" in the Biology Laboratory Course

    Science.gov (United States)

    Zheng, Zhi-Liang

    2006-01-01

    This article describes the use of the "glabrous1 (g11)" mutant and constitutively active "(CA)-rop2" transgenic plants of "Arabidopsis thaliana" in teaching genetics laboratory for both high school and undergraduate students. The experiments provide students with F[subscript 1] and F[subscript 2] generations within a semester for genetic and…

  5. Neomysin inhibits Ca2+-stimulated phosphatidylinositol hydrolysis and protects cultured rat cardiomyocytes from Ca2+-dependent cell injury

    International Nuclear Information System (INIS)

    Babson, J.R.; Dougherty, J.M.

    1991-01-01

    Exposure of cultured rat cardiomyocytes to ionomycin and extracellular Ca 2+ leads to a rapid, sustained increase in intracellular free Ca 2+ as monitored by Ca 2+ -dependent phosphorylase a activation and to a subsequent loss of cardiomyocyte viability as determined by lactate dehydrogenase (LDH) leakage. The intracellular free Ca 2+ increase coincided with a rapid hydrolysis of phosphatidylinositol that preceded cell death. Phosphatidylinositol hydrolysis was monitored by the release of radiolabeled phosphoinositides from cardiomyocytes prelabeled with [2- 3 H]-myo-inositol. Neomycin, a known inhibitor of phospholipase C, inhibited the phosphatidylinositol hydrolysis and markedly reduced the extent of cell injury. Inhibitors of other Ca 2+ -activated processes, including intracellular proteases and phospholipase A 2 , had no effect on ionomycin-mediated cell injury. These data suggest that ionomycin-induced Ca 2+ -dependent cell injury in cultured cardiomyocytes may be due in part to the stimulation of phosphatidylinositol hydrolysis, presumably catalyzed by a Ca 2+ -dependent phospholipase C

  6. Assessment of diagnostic value of various tumors markers (CEA, CA199, CA50) for colorectal neoplasm with logistic regression and ROC curve

    International Nuclear Information System (INIS)

    Gu Ping; Huang Gang; Han Yuan

    2007-01-01

    Objective: To assess the diagnostic value of CEA, CA199 and CA50 for colorectal neoplasm by logistic regression and ROC curve. Methods: Serum CEA (with CLIA), CA199 (with ECLIA) and CA50 (with IRMA) levels were measured in 75 patients with colorectal cancer, 35 patients with benign colorectal disorders and 49 controls. The area under the ROC curve (AUC)s of CEA, CA199, CA50 from logistic regression results were compared. Results: In the cancer-benign disorder group, the AUC of CA50 was larger than the AUC of CA199. AUC of combined CEA, CA50 was largest: not only larger than any AUC of CEA, CA50, CA199 alone but also larger than the AUC of the combined three markers (0.875 vs 0.604). In cancer-control group, the AUC of combination of CEA, CA199 and CA50 was larger than any AUC of CEA, CA199 or CA50 alone. Both in the cancer-benign disorder group or cancer-control group, the AUC of CEA was larger than the AUC of CA199 or CA50. Conclusion: CEA is of definite value in the diagnosis of colorectal cancer. For differential diagnosis, the combination of CEA and CA50 can give more information, while the combination of three tumor markers is less helpful. As an advanced statistical method, logistic regression can improve the diagnostic sensitivity and specificity. (authors)

  7. An outbreak of community-associated methicilin-resistant Staphylococcus aureus infection in a boarding school in Hong Kong (China

    Directory of Open Access Journals (Sweden)

    Wong Mui-ling

    2014-01-01

    Full Text Available Background: In November 2012, an outbreak of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA skin and soft tissue infections affecting students at a boarding school in Hong Kong (China was detected. Methods: A case was defined as any student or staff notified with MRSA infection from 25 October 2012 to 5 July 2013 with the clinical isolate being of staphylococcal cassette chromosome mec type IV or V and positive for Panton-Valentine leukocidin gene. We conducted field investigations, advised on control measures and enhanced surveillance for skin and soft tissue infections at the school. Decolonization therapies were offered to all cases and contacts, and carrier screening was conducted. Results: There were five cases; two (40% were hospitalized and three (60% required surgical treatments. Initial screening comprised 240 students and 81 staff members. Overall, four cases (80% plus eight other students (3.3% were carriers, with eight of 12 (66.7% from the same dormitory. All staff members screened negative. After intensified control measures, the number of students screened positive for CA-MRSA decreased from nine to one with no more cases identified in the school. Conclusion: Identification of carriers, decolonization therapy, monitoring of cases and contacts and strengthening of environmental and personal hygiene were control measures that helped contain this CA-MRSA outbreak in a boarding school in Hong Kong (China.

  8. CaMKII determines mitochondrial stress responses in heart

    Science.gov (United States)

    Joiner, Mei-ling A.; Koval, Olha M.; Jingdong, Li; He, B. Julie; Allamargot, Chantal; Gao, Zhan; Luczak, Elizabeth D.; Hall, Duane D.; Fink, Brian D.; Chen, Biyi; Yang, Jinying; Moore, Steven A.; Scholz, Thomas D.; Strack, Stefan; Mohler, Peter J.; Sivitz, William I.; Song, Long-Sheng; Anderson, Mark E.

    2012-01-01

    Myocardial cell death is initiated by excessive mitochondrial Ca2+ entry, causing Ca2+ overload, mitochondrial permeability transition pore (mPTP) opening and dissipation of the mitochondrial inner membrane potential (ΔΨm)1,2. However, the signaling pathways that control mitochondrial Ca2+ entry through the inner membrane mitochondrial Ca2+ uniporter (MCU)3–5 are not known. The multifunctional Ca2+ and calmodulin-dependent protein kinase II (CaMKII) is activated in ischemia reperfusion (I/R), myocardial infarction (MI) and neurohumoral injury, common causes of myocardial death and heart failure, suggesting CaMKII could couple disease stress to mitochondrial injury. Here we show that CaMKII promotes mPTP opening and myocardial death by increasing MCU current (IMCU). Mitochondrial-targeted CaMKII inhibitory protein or cyclosporin A (CsA), an mPTP antagonist with clinical efficacy in I/R injury6, equivalently prevent mPTP opening, ΔΨm deterioration and diminish mitochondrial disruption and programmed cell death in response to I/R injury. Mice with myocardial and mitochondrial-targeted CaMKII inhibition are resistant to I/R injury, MI and neurohumoral injury, suggesting pathological actions of CaMKII are substantially mediated by increasing IMCU. Our findings identify CaMKII activity as a central mechanism for mitochondrial Ca2+ entry and suggest mitochondrial-targeted CaMKII inhibition could prevent or reduce myocardial death and heart failure dysfunction in response to common experimental forms of pathophysiological stress. PMID:23051746

  9. Tumour associated antigen CA-50, CA-242 immunoradiometric assay (IRMA) in genitourinary malignancy and gastrointestinal carcinoma early diagnosis

    International Nuclear Information System (INIS)

    Chen Zhizhou.

    1992-04-01

    Tumour markers CA-50 and CA-242 were measured by immunometric assay (IRMA) to investigate their usefulness in the diagnosis of cancer of the pancreas, biliary tract, liver, breast, lung, gastrointestinal and genitourinary systems. The cutoff points, derived from studies on normal subjects and those with proven benign disease, were 20 u/ml and 12 u/ml for CA-50 and CA-242 respectively. Both markers were found to be generally useful with significant differences between malignant and non malignant disease. The highest positive rates, were found in cancers of the pancreas and gall bladder. The overall rate of false positives was low. It is concluded that measurements of CA-50 and CA-242 are useful in the detection of malignancy, particularly of the pancreas and biliary tract. 2 figs, 2 tabs

  10. Wave energy converter effects on wave propagation: A sensitivity study in Monterey Bay, CA

    Science.gov (United States)

    Chang, G.; Jones, C. A.; Roberts, J.; Magalen, J.; Ruehl, K.; Chartrand, C.

    2014-12-01

    The development of renewable offshore energy in the United States is growing rapidly and wave energy is one of the largest resources currently being evaluated. The deployment of wave energy converter (WEC) arrays required to harness this resource could feasibly number in the hundreds of individual devices. The WEC arrays have the potential to alter nearshore wave propagation and circulation patterns and ecosystem processes. As the industry progresses from pilot- to commercial-scale it is important to understand and quantify the effects of WECs on the natural nearshore processes that support a local, healthy ecosystem. To help accelerate the realization of commercial-scale wave power, predictive modeling tools have been developed and utilized to evaluate the likelihood of environmental impact. At present, direct measurements of the effects of different types of WEC arrays on nearshore wave propagation are not available; therefore wave model simulations provide the groundwork for investigations of the sensitivity of model results to prescribed WEC characteristics over a range of anticipated wave conditions. The present study incorporates a modified version of an industry standard wave modeling tool, SWAN (Simulating WAves Nearshore), to simulate wave propagation through a hypothetical WEC array deployment site on the California coast. The modified SWAN, referred to as SNL-SWAN, incorporates device-specific WEC power take-off characteristics to more accurately evaluate a WEC device's effects on wave propagation. The primary objectives were to investigate the effects of a range of WEC devices and device and array characteristics (e.g., device spacing, number of WECs in an array) on nearshore wave propagation using SNL-SWAN model simulations. Results showed that significant wave height was most sensitive to variations in WEC device type and size and the number of WEC devices in an array. Locations in the lee centerline of the arrays in each modeled scenario showed the largest potential changes in wave height. The SNL-SWAN model simulations for various WEC devices provide the basis for a solid model understanding, giving the confidence necessary for future WEC evaluations.

  11. CaEDTA vs CaEDTA plus BAL to treat children with elevated blood lead levels.

    Science.gov (United States)

    O'Connor, M E

    1992-07-01

    The effectiveness of CaEDTA alone vs CaEDTA plus BAL was compared retrospectively in a group of 72 children with lead levels between 2.41 mumol/L (50 micrograms/dL) and 2.90 mumol/L (60 micrograms/dL). The children who received both drugs had higher median zinc protoporphyrin (ZnP) concentrations at the initiation of therapy than children who received CaEDTA alone (160 micrograms/dL vs 96 micrograms/dL, p less than .01). There was a significantly increased incidence of vomiting and abnormal liver-function test results in the children who received both drugs. The children who received CaEDTA alone had a greater percent mean fall in lead level at one to three weeks postchelation (30.5% vs 18.1%, p less than .05). Children who received both CaEDTA and BAL had a greater percent decrease in ZnP at four to eight months postchelation, but there was no difference in percent decrease in lead levels. Children who received both drugs also had a greater number of repeat courses of chelation by six months. The addition of BAL to CaEDTA for treatment of children with lead levels of 2.41 mumol/L (50 micrograms/dL) to 2.90 mumol/L (60 micrograms/dL) produced greater toxicity and does not seem to prevent repeat chelations within six months.

  12. Ca2+ pump and Ca2+/H+ antiporter in plasma membrane vesicles isolated by aqueous two-phase partitioning from corn leaves

    International Nuclear Information System (INIS)

    Kasai, M.; Muto, S.

    1990-01-01

    Plasma membrane vesicles, which are mostly right side-out, were isolated from corn leaves by aqueous two-phase partitioning method. Characteristics of Ca2+ transport were investigated after preparing inside-out vesicles by Triton X-100 treatment. 45Ca2+ transport was assayed by membrane filtration technique. Results showed that Ca2+ transport into the plasma membrane vesicles was Mg-ATP dependent. The active Ca2+ transport system had a high affinity for Ca2+(Km(Ca2+) = 0.4 microM) and ATP(Km(ATP) = 3.9 microM), and showed pH optimum at 7.5. ATP-dependent Ca2+ uptake in the plasma membrane vesicles was stimulated in the presence of Cl- or NO3-. Quenching of quinacrine fluorescence showed that these anions also induced H+ transport into the vesicles. The Ca2+ uptake stimulated by Cl- was dependent on the activity of H+ transport into the vesicles. However, carbonylcyanide m-chlorophenylhydrazone (CCCP) and VO4(3-) which is known to inhibit the H+ pump associated with the plasma membrane, canceled almost all of the Cl(-)-stimulated Ca2+ uptake. Furthermore, artificially imposed pH gradient (acid inside) caused Ca2+ uptake into the vesicles. These results suggest that the Cl(-)-stimulated Ca2+ uptake is caused by the efflux of H+ from the vesicles by the operation of Ca2+/H+ antiport system in the plasma membrane. In Cl(-)-free medium, H+ transport into the vesicles scarcely occurred and the addition of CCCP caused only a slight inhibition of the active Ca2+ uptake into the vesicles. These results suggest that two Ca2+ transport systems are operating in the plasma membrane from corn leaves, i.e., one is an ATP-dependent active Ca2+ transport system (Ca2+ pump) and the other is a Ca2+/H+ antiport system. Little difference in characteristics of Ca2+ transport was observed between the plasma membranes isolated from etiolated and green corn leaves

  13. CaWingz user's guide

    International Nuclear Information System (INIS)

    Cha, Ben-chin.

    1994-01-01

    This document assumes that you have read and understood the Wingz user's manuals. CaWingz is an external Wingz program which, when combined with a set of script files, provides easy-to-use EPICS channel access interface functions for Wingz users. The external function run allows Wingz user to invoke any Unix processor within caWingz. Few additional functions for accessing static database field and monitoring of value change event is available for EPICS users after release 3.11. The functions, script files, and usage are briefly described in this document. The script files supplied here serve as examples only. Users are responsible for generating their own spreadsheet and script files. CaWingz communicates with IOC through channel access function calls

  14. Protein Kinase Cα and P-Type Ca2+ Channel CaV2.1 in Red Blood Cell Calcium Signalling

    Directory of Open Access Journals (Sweden)

    Lisa Wagner-Britz

    2013-06-01

    Full Text Available Background/Aims: Protein kinase Cα (PKCα is activated by an increase in cytosolic Ca2+ in red blood cells (RBCs. Previous work has suggested that PKCα directly stimulates the CaV2.1 channel, whereas other studies revealed that CaV2.1 is insensitive to activation by PKC. The aim of this study was to resolve this discrepancy. Methods: We performed experiments based on a single cell read-out of the intracellular Ca2+ concentration in terms of Fluo-4 fluorescence intensity and phosphatidylserine exposure to the external membrane leaflet. Measurement modalities included flow cytometry and live cell imaging. Results: Treatment of RBCs with phorbol 12-myristate 13-acetate (PMA led to two distinct populations of cells with an increase in intracellular Ca2+: a weak-responding and a strong-responding population. The EC50 of PMA for the number of cells with Ca2+ elevation was 2.7±1.2 µM; for phosphatidylserine exposure to the external membrane surface, it was 2.8±0.5 µM; and for RBC haemolysis, it was 2.9±0.5 µM. Using pharmacological manipulation with the CaV2.1 inhibitor ω-agatoxin TK and the broad protein kinase C inhibitor Gö6983, we are able to show that there are two independent PMA-activated Ca2+ entry processes: the first is independent of CaV2.1 and directly PKCα-activated, while the second is associated with a likely indirect activation of CaV2.1. Further studies using lysophosphatidic acid (LPA as a stimulation agent have provided additional evidence that PKCα and CaV2.1 are not directly interconnected in a signalling chain. Conclusion: Although we provide evidence for a lack of interaction between PKCα and CaV2.1 in RBCs, further studies are required to decipher the signalling relationship between LPA, PKCα and CaV2.1.

  15. Lysosomes shape Ins(1,4,5)P3-evoked Ca2+ signals by selectively sequestering Ca2+ released from the endoplasmic reticulum

    Science.gov (United States)

    López-Sanjurjo, Cristina I.; Tovey, Stephen C.; Prole, David L.; Taylor, Colin W.

    2013-01-01

    Summary Most intracellular Ca2+ signals result from opening of Ca2+ channels in the plasma membrane or endoplasmic reticulum (ER), and they are reversed by active transport across these membranes or by shuttling Ca2+ into mitochondria. Ca2+ channels in lysosomes contribute to endo-lysosomal trafficking and Ca2+ signalling, but the role of lysosomal Ca2+ uptake in Ca2+ signalling is unexplored. Inhibition of lysosomal Ca2+ uptake by dissipating the H+ gradient (using bafilomycin A1), perforating lysosomal membranes (using glycyl-L-phenylalanine 2-naphthylamide) or lysosome fusion (using vacuolin) increased the Ca2+ signals evoked by receptors that stimulate inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] formation. Bafilomycin A1 amplified the Ca2+ signals evoked by photolysis of caged Ins(1,4,5)P3 or by inhibition of ER Ca2+ pumps, and it slowed recovery from them. Ca2+ signals evoked by store-operated Ca2+ entry were unaffected by bafilomycin A1. Video-imaging with total internal reflection fluorescence microscopy revealed that lysosomes were motile and remained intimately associated with the ER. Close association of lysosomes with the ER allows them selectively to accumulate Ca2+ released by Ins(1,4,5)P3 receptors. PMID:23097044

  16. Altered thalamocortical rhythmicity and connectivity in mice lacking CaV3.1 T-type Ca2+ channels in unconsciousness

    Science.gov (United States)

    Choi, Soonwook; Yu, Eunah; Lee, Seongwon; Llinás, Rodolfo R.

    2015-01-01

    In unconscious status (e.g., deep sleep and anesthetic unconsciousness) where cognitive functions are not generated there is still a significant level of brain activity present. Indeed, the electrophysiology of the unconscious brain is characterized by well-defined thalamocortical rhythmicity. Here we address the ionic basis for such thalamocortical rhythms during unconsciousness. In particular, we address the role of CaV3.1 T-type Ca2+ channels, which are richly expressed in thalamic neurons. Toward this aim, we examined the electrophysiological and behavioral phenotypes of mice lacking CaV3.1 channels (CaV3.1 knockout) during unconsciousness induced by ketamine or ethanol administration. Our findings indicate that CaV3.1 KO mice displayed attenuated low-frequency oscillations in thalamocortical loops, especially in the 1- to 4-Hz delta band, compared with control mice (CaV3.1 WT). Intriguingly, we also found that CaV3.1 KO mice exhibited augmented high-frequency oscillations during unconsciousness. In a behavioral measure of unconsciousness dynamics, CaV3.1 KO mice took longer to fall into the unconscious state than controls. In addition, such unconscious events had a shorter duration than those of control mice. The thalamocortical interaction level between mediodorsal thalamus and frontal cortex in CaV3.1 KO mice was significantly lower, especially for delta band oscillations, compared with that of CaV3.1 WT mice, during unconsciousness. These results suggest that the CaV3.1 channel is required for the generation of a given set of thalamocortical rhythms during unconsciousness. Further, that thalamocortical resonant neuronal activity supported by this channel is important for the control of vigilance states. PMID:26056284

  17. Ablation of Ca(V)2.1 voltage-gated Ca²⁺ channels in mouse forebrain generates multiple cognitive impairments.

    Science.gov (United States)

    Mallmann, Robert Theodor; Elgueta, Claudio; Sleman, Faten; Castonguay, Jan; Wilmes, Thomas; van den Maagdenberg, Arn; Klugbauer, Norbert

    2013-01-01

    Voltage-gated Ca(V)2.1 (P/Q-type) Ca²⁺ channels located at the presynaptic membrane are known to control a multitude of Ca²⁺-dependent cellular processes such as neurotransmitter release and synaptic plasticity. Our knowledge about their contributions to complex cognitive functions, however, is restricted by the limited adequacy of existing transgenic Ca(V)2.1 mouse models. Global Ca(V)2.1 knock-out mice lacking the α1 subunit Cacna1a gene product exhibit early postnatal lethality which makes them unsuitable to analyse the relevance of Ca(V)2.1 Ca²⁺ channels for complex behaviour in adult mice. Consequently we established a forebrain specific Ca(V)2.1 knock-out model by crossing mice with a floxed Cacna1a gene with mice expressing Cre-recombinase under the control of the NEX promoter. This novel mouse model enabled us to investigate the contribution of Ca(V)2.1 to complex cognitive functions, particularly learning and memory. Electrophysiological analysis allowed us to test the specificity of our conditional knock-out model and revealed an impaired synaptic transmission at hippocampal glutamatergic synapses. At the behavioural level, the forebrain-specific Ca(V)2.1 knock-out resulted in deficits in spatial learning and reference memory, reduced recognition memory, increased exploratory behaviour and a strong attenuation of circadian rhythmicity. In summary, we present a novel conditional Ca(V)2.1 knock-out model that is most suitable for analysing the in vivo functions of Ca(V)2.1 in the adult murine forebrain.

  18. A model of cardiac ryanodine receptor gating predicts experimental Ca2+-dynamics and Ca2+-triggered arrhythmia in the long QT syndrome

    Science.gov (United States)

    Wilson, Dan; Ermentrout, Bard; Němec, Jan; Salama, Guy

    2017-09-01

    Abnormal Ca2+ handling is well-established as the trigger of cardiac arrhythmia in catecholaminergic polymorphic ventricular tachycardia and digoxin toxicity, but its role remains controversial in Torsade de Pointes (TdP), the arrhythmia associated with the long QT syndrome (LQTS). Recent experimental results show that early afterdepolarizations (EADs) that initiate TdP are caused by spontaneous (non-voltage-triggered) Ca2+ release from Ca2+-overloaded sarcoplasmic reticulum (SR) rather than the activation of the L-type Ca2+-channel window current. In bradycardia and long QT type 2 (LQT2), a second, non-voltage triggered cytosolic Ca2+ elevation increases gradually in amplitude, occurs before overt voltage instability, and then precedes the rise of EADs. Here, we used a modified Shannon-Puglisi-Bers model of rabbit ventricular myocytes to reproduce experimental Ca2+ dynamics in bradycardia and LQT2. Abnormal systolic Ca2+-oscillations and EADs caused by SR Ca2+-release are reproduced in a modified 0-dimensional model, where 3 gates in series control the ryanodine receptor (RyR2) conductance. Two gates control RyR2 activation and inactivation and sense cytosolic Ca2+ while a third gate senses luminal junctional SR Ca2+. The model predicts EADs in bradycardia and low extracellular [K+] and cessation of SR Ca2+-release terminate salvos of EADs. Ca2+-waves, systolic cell-synchronous Ca2+-release, and multifocal diastolic Ca2+ release seen in subcellular Ca2+-mapping experiments are observed in the 2-dimensional version of the model. These results support the role of SR Ca2+-overload, abnormal SR Ca2+-release, and the subsequent activation of the electrogenic Na+/Ca2+-exchanger as the mechanism of TdP. The model offers new insights into the genesis of cardiac arrhythmia and new therapeutic strategies.

  19. Caffeine intake and abstract reasoning among 1374 unselected men and women from general population. Role of the -163C>A polymorphism of CYP1A2 gene.

    Science.gov (United States)

    Casiglia, Edoardo; Tikhonoff, Valérie; Albertini, Federica; Favaro, Jacopo; Montagnana, Martina; Danese, Elisa; Finatti, Francesco; Benati, Marco; Mazza, Alberto; Dal Maso, Lucia; Spinella, Paolo; Palatini, Paolo

    2017-08-01

    The possible effect of caffeine as an enhancer of cognitive performance, particularly that on abstract reasoning, has never been studied in an epidemiological setting, especially in relation to -163C>A polymorphism of CYP1A2 gene, largely controlling caffeine metabolism. Aim of this study was to ascertain whether in general population free chronic caffeine intake modifies abstract reasoning, and if this effect is influenced by the above mentioned genotype, by age, schooling, ethanol intake and smoking habits. We studied 1374 unselected men and women aged 51 ± 15 years (range 18-89) from a general population. Daily caffeine intake deriving from coffee, tea, chocolate or cola was calculated from an anamnestic questionnaire and from a 7-day dietary diary. Abstract reasoning was measured in the frame of a neuropsychological assessment as the ability to find a concept linking two words indicating objects or actions and explaining how they were connected. In age-schooling-adjusted linear regression, the higher the caffeine intake, the better the abstraction score. Abstract reasoning depended on caffeine in the -163C>A CC homozygous only (so-called slow metabolizers), where it was higher in the 3rd tertile of caffeine intake. Age and ethanol reduced while smoking and schooling enhanced this association. The interaction term between caffeine and the -163C>A polymorphism was accepted in linear regressions. Caffeine consumption resulted innocuous for the A-carriers (so-called fast metabolizers). In general population, a positive association between caffeine intake and abstract reasoning exists in the CC homozygous of the -163C>A polymorphism of CYP1A2 gene. Copyright © 2017 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.

  20. CA 19-9 and CA 125 as potential predictors of disease recurrence in resectable lung adenocarcinoma.

    Directory of Open Access Journals (Sweden)

    Sofi Isaksson

    Full Text Available Among patients who underwent primary surgery for non-small cell lung cancer (NSCLC, recurrent disease is frequent and cannot be accurately predicted solely from TNM stage and histopathological features. The aim of this study was to examine the association of tumor markers in pre-operative serum with recurrent disease.Blood samples were collected prior to lung cancer surgery from 107 patients with stage I-III lung adenocarcinoma surgically treated at Lund University hospital, Lund, Sweden, between 2005 and 2011. The serum tumor markers Carcinoembryonic antigen (CEA, Neuron-specific enolase (NSE, Cancer antigen 125 (CA 125, Human epididymis protein 4 (HE4 and Carbohydrate antigen (CA 19-9 were analyzed retrospectively and clinical follow-up data were collected from patient charts. Forty (37% patients were diagnosed with recurrent disease.Sixty-eight (64% patients had at least one elevated tumor marker prior to surgery. In analysis of disease-free survival (DFS, CA 125 and/or CA 19-9 were significantly associated with recurrent disease adjusted to stage and adjuvant treatment (hazard ratio 2.8, 95% confidence interval 1.4-5.7, p = 0.006.High pre-operative serum CA 19-9 and/or CA 125 might indicate an increased incidence of recurrent disease in resectable lung adenocarcinomas.

  1. Non-Conscious Sex Role Ideology: The Implications for Optimal Utilization of U.S. Servicewomen.

    Science.gov (United States)

    1984-03-01

    trayed in or encouraged towards culturally stereotyped "appropriate" roles [Ref. 17: p. 561. It is reflected in women’s magazines and newspapers where...Ref. 22: p. 130]. But the firmly entrenched Army mentality towards women prevailed, in spite of intentions to the contrary. Women were considered...DA4502 NON-CONSIU ’E NOL 000LG THE M A ONS FOR 12~~~~~OPTMLUIIAIN 0 N R WOME U NAVAL UPOSTGRDUATE SCHO 0 MONTEREY CA M BOYNTON MAR 84 UN7SSFE F/G

  2. The investigation of minoxidil-induced [Ca2+]i rises and non-Ca2+-triggered cell death in PC3 human prostate cancer cells.

    Science.gov (United States)

    Chen, I-Shu; Chou, Chiang-Ting; Liu, Yuan-Yuarn; Yu, Chia-Cheng; Liang, Wei-Zhe; Kuo, Chun-Chi; Shieh, Pochuen; Kuo, Daih-Huang; Chen, Fu-An; Jan, Chung-Ren

    2017-02-01

    Minoxidil is clinically used to prevent hair loss. However, its effect on Ca 2+ homeostasis in prostate cancer cells is unclear. This study explored the effect of minoxidil on cytosolic-free Ca 2+ levels ([Ca 2+ ] i ) and cell viability in PC3 human prostate cancer cells. Minoxidil at concentrations between 200 and 800 μM evoked [Ca 2+ ] i rises in a concentration-dependent manner. This Ca 2+ signal was inhibited by 60% by removal of extracellular Ca 2+ . Minoxidil-induced Ca 2+ influx was confirmed by Mn 2+ -induced quench of fura-2 fluorescence. Pre-treatment with the protein kinase C (PKC) inhibitor GF109203X, PKC activator phorbol 12-myristate 13 acetate (PMA), nifedipine and SKF96365 inhibited minoxidil-induced Ca 2+ signal in Ca 2+ containing medium by 60%. Treatment with the endoplasmic reticulum Ca 2+ pump inhibitor 2,5-ditert-butylhydroquinone (BHQ) in Ca 2+ -free medium abolished minoxidil-induced [Ca 2+ ] i rises. Conversely, treatment with minoxidil abolished BHQ-induced [Ca 2+ ] i rises. Inhibition of phospholipase C (PLC) with U73122 abolished minoxidil-evoked [Ca 2+ ] i rises. Overnight treatment with minoxidil killed cells at concentrations of 200-600 μM in a concentration-dependent fashion. Chelation of cytosolic Ca 2+ with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid/AM (BAPTA/AM) did not prevent minoxidil's cytotoxicity. Together, in PC3 cells, minoxidil induced [Ca 2+ ] i rises that involved Ca 2+ entry through PKC-regulated store-operated Ca 2+ channels and PLC-dependent Ca 2+ release from the endoplasmic reticulum. Minoxidil-induced cytotoxicity in a Ca 2+ -independent manner.

  3. Diagnostic significance of tumor markers CEA, CA50 and CA19-9 for colorectal cancer

    International Nuclear Information System (INIS)

    Chen Yumei; Huang Gang

    2005-01-01

    Objective: To investigate the expression and diagnostic significance of three serum tumor markers (CEA, CA50, CA19-9) in patients with colorectal cancer, with special emphasis on their combined assay. Methods: Serum CEA, CA19-9 levels (with chemiluminescence immunoassay) and CA50 levels (with immunoradiometric assay) were determined in 94 patients with colorectal cancer, 20 patients with benign colorectal disorders and 37 controls. Results: The expressions of the serum tumor markers were significantly higher in patients with colorectal cancer than those in patients with benign colorectal disorders and controls (P<0.05). There was no significant difference between the levels in the latter two groups. CEA assay had the highest sensitivity (57.4%) and specificity (85.9%). Combined assay of the three could enhance both the sensitivity (62.7%) and specificity (96.5%). The serum levels of the markers were significantly higher in patients with colonic cancer than those in patients with rectal cancer (P<0.05). The levels were positively correlated with the size of the growth and stage of the disease. Serum tumor marker levels were also significantly higher in patients with metastasis (regional/distant) than those in patients without metastasis (P<0.05). Conclusion: Determination of serum CEA, CA50 and CA19-9 levels had definite value for the diagnosis and assessment of the pathology as well as biologic behavior colorectal cancer. Combined assay of the three could enhance the diagnostic sensitivity and specificity. (authors)

  4. Study on the diagnostic value of combined determination of serum CA125, CA199 and SIL-2R levels in patients with endometriosis

    International Nuclear Information System (INIS)

    Yang Jingxiu; Shi Shaohong; Wang Yuping; Xie Xueqin; Qin Jibao

    2005-01-01

    Objective: To investigate the diagnostic values of combined determination of serum CA125, CA199 and SIL-2R levels in patients with endometriosis. Methods: Serum CA125, CA199 were measured with RIA and SIL-2R levels with ELISA in 54 patients with endometriosis and 35 controls. Results: The serum levels of CA125, CA199 and SIL-2R in patients with endometriosis were significantly higher than those in controls (P<0.01). The sensitivity and speciality of CA125 for endometriosis was 70.2% and 80.4% respectively, the sensitivity and speciality of CA199 for endometriosis was 62.4% and 71.8% respectively, the sensitivity and speciality of SIL-2R was 89.5% and 60.2% respectively. The sensitivity of the combined determination of CA125, CA199 and SIL-2R for endometriosis was 86.8% being significantly higher than that of CA125 and CA199 respectively. Conclusion: Combined determination of the serum CA125, CA199 and SIL-2R levels in serum can increase the diagnostic sensitivity for endometriosis. (authors)

  5. Thermal neutrons thermoluminescence dosimetry using CaF2 + KBr e CaSO4: Dy + Br

    International Nuclear Information System (INIS)

    Leite, A.M.P.

    1979-01-01

    Cold-pressed samples of CaF 2 + KBr and CaSO 4 :Dy + KBr have been used in the thermal neutron detection by the thermoluminescence technique. The amount of 100 mg of the TL phosphor added to 80 mg of KBr showed to be the optimum mixture regarding sensitivity as well as the handling of the dosimeters. The detection is based on the self-irradiation of the phosphor by the Br isotopes activated by exposure to a neutron-gama field. The prompt dose and consequentely the gama contribution are erased by post-irradiation thermal annealing. A linear dependence has been found between the TL self-induced signal and the thermal neutron flux in the range 10 6 n.cm -2 .seg -1 -10 -12 n.cm -2 .seg -1 . The minimum detectable fluence has benn determined as 10 9 n.cm -2 and 10 6 n.cm -2 using pellets of CaF 2 + KBr and CaSO 4 :Dy + KBr, respectively. The main results suggest the use of CaSO 4 :Dy + KBr pellets and TL as a complementary technique for thermal neutron detection. (author) [pt

  6. Glucagon releases Ca2+ from a FCCP-sensitive pool

    International Nuclear Information System (INIS)

    Kraus-Friedmann, N.

    1986-01-01

    The effects of physiological levels of glucagon on Ca 2+ efflux were examined in the perfused rat liver. Two methods were used to estimate Ca 2+ efflux: (1) prior labeling of the Ca 2+ pools with 45 Ca 2+ , and (2) measurement of perfusate Ca 2+ with atomic absorption. According to both methods, glucagon administration at the physiological level evoked Ca 2+ release. In order to identify the hormone-sensitive Ca 2+ pool, a method employed by several laboratories was used. In this method, mitochondrial Ca 2+ is released by FCCP, (carbonyl-cyanide 4 (trifluoro/methoxy) phenylhydrazone), a mitochondrial uncoupler. The effect of hormones on Ca 2+ release after such uncoupler administration is measured. A decreased release is taken as an indication that the pool is entirely or partially mitochondrial. FCCP released 90 +/- 29 nmoles Ca 2+ /gr wet liver. Glucagon (5 x 10 -9 M) released 107 +/- 45 nmoles Ca 2+ /gr wet liver before and 26 +/- 9 nmoles Ca 2+ /gr wet liver after FCCP. These data indicate that glucagon releases Ca 2+ mostly from the mitochondria

  7. IP3 stimulates CA++ efflux from fusogenic carrot protoplasts

    International Nuclear Information System (INIS)

    Rincon, M.; Boss, W.F.

    1986-01-01

    Polyphosphoinositide breakdown plays an important role in signal transduction in animal cells (Berridge and Irvine, 1984, Nature, 312:315). Upon stimulation, phospholipase C hydrolyzes phosphatidylinositol 4,5-bisphosphate to inositol 1,4,5-trisphosphate (IP 3 ) and diacylglycerol both of which act as cellular second messengers. IP 3 mobilizes Ca ++ from internal stores, hence the cytosolic free Ca ++ concentration increases and those physiological activities regulated by Ca ++ are stimulated. To test if plant cells also responded to IP 3 , Ca ++ efflux studies were done with fusogenic carrot protoplasts released in EGTA. The protoplasts were preloaded with 45 Ca ++ placed in a Ca ++ -free medium, and efflux determined as 45 Ca ++ loss from the protoplasts. IP 3 (10-20μM) caused enhanced 45 Ca ++ efflux and the response was sustained for at least 15 min. In plants, as in animals, the observed IP 3 -enhanced 45 Ca ++ efflux suggested that IP 3 released Ca ++ from internal stores, and the increased free cytosolic Ca ++ activated Ca ++ pumping mechanisms which restored the Ca ++ concentration in the cytosol to the normal level

  8. Ablation of Ca(V2.1 voltage-gated Ca²⁺ channels in mouse forebrain generates multiple cognitive impairments.

    Directory of Open Access Journals (Sweden)

    Robert Theodor Mallmann

    Full Text Available Voltage-gated Ca(V2.1 (P/Q-type Ca²⁺ channels located at the presynaptic membrane are known to control a multitude of Ca²⁺-dependent cellular processes such as neurotransmitter release and synaptic plasticity. Our knowledge about their contributions to complex cognitive functions, however, is restricted by the limited adequacy of existing transgenic Ca(V2.1 mouse models. Global Ca(V2.1 knock-out mice lacking the α1 subunit Cacna1a gene product exhibit early postnatal lethality which makes them unsuitable to analyse the relevance of Ca(V2.1 Ca²⁺ channels for complex behaviour in adult mice. Consequently we established a forebrain specific Ca(V2.1 knock-out model by crossing mice with a floxed Cacna1a gene with mice expressing Cre-recombinase under the control of the NEX promoter. This novel mouse model enabled us to investigate the contribution of Ca(V2.1 to complex cognitive functions, particularly learning and memory. Electrophysiological analysis allowed us to test the specificity of our conditional knock-out model and revealed an impaired synaptic transmission at hippocampal glutamatergic synapses. At the behavioural level, the forebrain-specific Ca(V2.1 knock-out resulted in deficits in spatial learning and reference memory, reduced recognition memory, increased exploratory behaviour and a strong attenuation of circadian rhythmicity. In summary, we present a novel conditional Ca(V2.1 knock-out model that is most suitable for analysing the in vivo functions of Ca(V2.1 in the adult murine forebrain.

  9. Oxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy.

    Science.gov (United States)

    Wang, Qiongling; Quick, Ann P; Cao, Shuyi; Reynolds, Julia; Chiang, David Y; Beavers, David; Li, Na; Wang, Guoliang; Rodney, George G; Anderson, Mark E; Wehrens, Xander H T

    2018-04-01

    Duchenne muscular dystrophy patients are prone to ventricular arrhythmias, which may be caused by abnormal calcium (Ca 2+ ) homeostasis and elevated reactive oxygen species. CaMKII (Ca 2+ /calmodulin-dependent protein kinase II) is vital for normal Ca 2+ homeostasis, but excessive CaMKII activity contributes to abnormal Ca 2+ homeostasis and arrhythmias in cardiomyocytes. Reactive oxygen species induce CaMKII to become autonomously active. We hypothesized that genetic inhibition of CaMKII oxidation (ox-CaMKII) in a mouse model of Duchenne muscular dystrophy can alleviate abnormal Ca 2+ homeostasis, thus, preventing ventricular arrhythmia. The objective of this study was to test if selective loss of ox-CaMKII affects ventricular arrhythmias in the mdx mouse model of Duchenne muscular dystrophy. 5-(6)-Chloromethyl-2,7-dichlorodihydrofluorescein diacetate staining revealed increased reactive oxygen species production in ventricular myocytes isolated from mdx mice, which coincides with elevated ventricular ox-CaMKII demonstrated by Western blotting. Genetic inhibition of ox-CaMKII by knockin replacement of the regulatory domain methionines with valines (MM-VV [CaMKII M281/282V]) prevented ventricular tachycardia in mdx mice. Confocal calcium imaging of ventricular myocytes isolated from mdx :MM-VV mice revealed normalization of intracellular Ca 2+ release events compared with cardiomyocytes from mdx mice. Abnormal action potentials assessed by optical mapping in mdx mice were also alleviated by genetic inhibition of ox-CaMKII. Knockout of the NADPH oxidase regulatory subunit p47 phox normalized elevated ox-CaMKII, repaired intracellular Ca 2+ homeostasis, and rescued inducible ventricular arrhythmias in mdx mice. Inhibition of reactive oxygen species or ox-CaMKII protects against proarrhythmic intracellular Ca 2+ handling and prevents ventricular arrhythmia in a mouse model of Duchenne muscular dystrophy. © 2018 American Heart Association, Inc.

  10. Cation-exchange antibody labeling for simultaneous electrochemical detection of tumor markers CA15-3 and CA19-9

    International Nuclear Information System (INIS)

    Wang, Guangjie; Qing, Yi; Shan, Jinlu; Jin, Feng; Wang, Dong; Yuan, Ruo

    2013-01-01

    We report on a new kind of non-covalent multi-label electrochemical immunoassay that was applied to simultaneously quantify the tumor markers CA15-3 and CA19-9. The method employs a nanohybrid composed of an ionomer and conductive titanium dioxide nanoparticles that act as a matrix support for the antibodies. The two antibodies (anti-CA153 and anti-CA199) were labeled (a) with a cobaltous dipyridine complex, and (b) with methylene blue. Labeling is based on cation-exchange interaction rather than on covalent conjugation. The redox potentials of the two labels are separated by an interval of 0.3 V. The resulting sandwich-type immunosensor was read out by differential pulse voltammetry. The potential sites and currents of the two redox probes reflect the concentration of the two analytes. The two analytes were determined with a detection limit of 1.6 U mL −1 for CA19-9, and of 0.3 U mL −1 for CA15-3 (author)

  11. The Stranger within: Luxembourg's Early School System as a European Prototype of Nationally Legitimized International Blends (ca. 1794-1844)

    Science.gov (United States)

    Thyssen, Geert

    2013-01-01

    This comparative analysis of Luxembourg's early school (law) system reveals the extent to which European school systems reflect "national-cultural idiosyncrasies" apart from "structural isomorphism". It first examines the legal soil into which the Luxembourg school system was implanted. Legislative pendular swings, reflecting…

  12. Juvenile Hippocampal CA2 Region Expresses Aggrecan

    Directory of Open Access Journals (Sweden)

    Asako Noguchi

    2017-05-01

    Full Text Available Perineuronal nets (PNNs are distributed primarily around inhibitory interneurons in the hippocampus, such as parvalbumin-positive interneurons. PNNs are also present around excitatory neurons in some brain regions and prevent plasticity in these neurons. A recent study demonstrated that PNNs also exist around mouse hippocampal pyramidal cells, which are the principle type of excitatory neurons, in the CA2 subregion and modulate the excitability and plasticity of these neurons. However, the development of PNNs in the CA2 region during postnatal maturation was not fully investigated. This study found that a main component of PNNs, aggrecan, existed in the pyramidal cell layer of the putative CA2 subarea prior to the appearance of the CA2 region, which was defined by the CA2 marker protein regulator of G protein signaling 14 (RGS14. We also found that aggrecan immunoreactivity was more evident in the anterior sections of the CA2 area than the posterior sections, which suggests that the function of CA2 PNNs varies along the anterior-posterior axis.

  13. Computer-Aided Prototyping Systems (CAPS) within the software acquisition process: a case study

    OpenAIRE

    Ellis, Mary Kay

    1993-01-01

    Approved for public release; distribution is unlimited This thesis provides a case study which examines the benefits derived from the practice of computer-aided prototyping within the software acquisition process. An experimental prototyping systems currently in research is the Computer Aided Prototyping System (CAPS) managed under the Computer Science department of the Naval Postgraduate School, Monterey, California. This thesis determines the qualitative value which may be realized by ...

  14. A Study Of The Internet Of Things And Rfid Technology: Big Data In Navy Medicine

    Science.gov (United States)

    2017-12-01

    technology on electrical power poses a threat to hospitals as well. In the event a power failure either from natural or nefarious purposes, the...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT A STUDY OF THE INTERNET OF THINGS AND RFID TECHNOLOGY ...December 2017 3. REPORT TYPE AND DATES COVERED MBA professional report 4. TITLE AND SUBTITLE A STUDY OF THE INTERNET OF THINGS AND RFID TECHNOLOGY : BIG

  15. Spare Parts Inventory Management for the Next Generation Finnish Defense Force Fighter Fleet

    Science.gov (United States)

    2017-12-01

    might benefit the end user most in high criticality or high cost classification classes: CrA, CrB, EA and EB. H. LEAD TIME EFFECTS Lead time is...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. SPARE PARTS INVENTORY MANAGEMENT...Eddine Dahel THIS PAGE INTENTIONALLY LEFT BLANK i REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704–0188 Public reporting burden for this collection

  16. A Computer Program to Model Passive Acoustic Antisubmarine Search Using Monte Carlo Simulation Techniques.

    Science.gov (United States)

    1983-09-01

    duplicate a continuous function on a digital computer, and thus the machine representatic- of the GMA is only a close approximation of the continuous...error process. Thus, the manner in which the GMA process is digitally replicated has an effect on the results of the simulation. The parameterization of...Information Center 2 Cameron Station Alexandria, Virginia 22314 2. Libary , Code 0142 2 Naval Postgraduate School Monterey, California 93943 3. Professor

  17. NPS-SCAT: Electrical Power System

    Science.gov (United States)

    2009-09-01

    Postgraduate School thesis, 2009. 5 M.P. Schroer, NPS-SCAT; A Cubesat Communications System Design, Test, and Intergration . Monterey: Naval...AIAA, 2007. 9 production of the 2400 unit. Communication testing of the 2420 unit initially showed great promise. Data rates that would easily...After a review of available products , the Clyde Space EPS was selected based on three major considerations. One, the Clyde Space unit had been flown on

  18. Channel CAT: A Tactical Link Analysis Tool

    Science.gov (United States)

    1997-09-01

    NAVAL POSTGRADUATE SCHOOL Monterey, California THESIS CHANNEL CAT : A TACTICAL LINK ANALYSIS TOOL by Michael Glenn Coleman September 1997 Thesis...REPORT TYPE AND DATES COVERED September 1997 Master’s Thesis 4. TITLE AND SUBTITLE CHANNEL CAT : A TACTICAL LINK ANALYSIS TOOL 5. FUNDING NUMBERS 6...tool, the Channel Capacity Analysis Tool (Channel CAT ), designed to provide an automated tool for the anlysis of design decisions in developing client

  19. Multiple Autonomous Vehicles for Minefield Reconnaissance and Mapping

    Science.gov (United States)

    1997-12-01

    NPS-ME-97-008 NAVAL POSTGRADUATE SCHOOL Monterey, California ItC A D- 19980421 131 =C QUALTY Ui Ji.CTEJ) THESIS MULTIPLE AUTONOMOUS VEHICLES FOR...MULTIPLE AUTONOMOUS VEHICLES FOR MINEFIELD 5. FUNDING NUMBERS RECONNAISSANCE AND MAPPING N0001497WX30039 6. AUTHOR(S) Jack A. Starr 7. PERFORMING... AUTONOMOUS VEHICLES FOR MINEFIELD RECONNAISSANCE AND MAPPING Jack A. Starr Lieutenant, United States Navy B.S., Oregon State University, 1991 Submitted in

  20. Investigation of the Emissivity and Suitability of a Carbon Thin Film for Terahertz Absorbers

    Science.gov (United States)

    2016-06-01

    however, the understanding that the introduction of a carbon thin film could reduce signal loss and will result in a change in thermal fluctuations is...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS INVESTIGATION OF THE EMISSIVITY AND SUITABILITY OF A CARBON THIN FILM FOR TERAHERTZ ABSORBERS...TITLE AND SUBTITLE INVESTIGATION OF THE EMISSIVITY AND SUITABILITY OF A CARBON THIN FILM FOR TERAHERTZ ABSORBERS 5. FUNDING NUMBERS 6. AUTHOR(S) Naomi C

  1. Operational Ocean Modelling with the Harvard Ocean Prediction System

    Science.gov (United States)

    2008-11-01

    tno.nl TNO-rapportnummer TNO-DV2008 A417 Opdrachtnummer Datum november 2008 Auteur (s) dr. F.P.A. Lam dr. ir. M.W. Schouten dr. L.A. te Raa...area of theory and implementation of numerical schemes and parameterizations, ocean models have grown from experimental tools to full-blown ocean...sound propagation through mesoscale features using 3-D coupled mode theory , Thesis, Naval Postgraduate School, Monterey, USA. 1992. [9] Robinson

  2. Systems Engineering of Unmanned DoD Systems: Following the Joint Capabilities Integration and Development System/Defense Acquisition System Process to Develop an Unmanned Ground Vehicle System

    Science.gov (United States)

    2015-12-01

    Manual D-A-1). APAs are “Performance attributes of a system not important enough to be considered KPPs or KSAs, but still appropriate to include in...the CDD or CPD are designated as APAs ” (JCIDS Manual D-A-1). The requirements are expressed using Thresholds (T) and Objectives (O). “Performance...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA SYSTEMS ENGINEERING CAPSTONE PROJECT REPORT Approved for public release; distribution is

  3. An Axisymmetric View of Concentric Eyewall Evolution in Hurricane Rita (2005)

    Science.gov (United States)

    2012-08-01

    of Hurricane Hugo (1989). Mon. Wea. Rev., 136, 1237–1259. Martinez, Y., G. Brunet, and M. K. Yau, 2010: On the dynamics of two-dimensional hurricane ...An Axisymmetric View of Concentric Eyewall Evolution in Hurricane Rita (2005) MICHAEL M. BELL Naval Postgraduate School, Monterey, California, and... Hurricane Research Division, Miami, Florida WEN-CHAU LEE National Center for Atmospheric Research,* Boulder, Colorado (Manuscript received 23 June 2011, in

  4. Effects of Personnel Injuries on Cinc Mission Readiness

    Science.gov (United States)

    1997-09-01

    activities in which injury may be sustained: ACTSPEC (activity specific): 1 =N/A 5 = 0 Course 9 = Fastrope 13 = Patrolling 2 = Running 6 = Weightlifting 10...NAVAL POSTGRADUATE SCHOOL Monterey, California THESIS EFFECTS OF PERSONNEL INJURIES ON CINC MISSION READINESS by Erin G. Snow September, 1997...Thesis 4. TITLE AND SUBTITLE EFFECTS OF PERSONNEL INJURIES ON CINC MISSION READINESS 6. AUTHOR(S) Snow, Erin G. 5. FUNDING NUMBERS 7. PERFORMING

  5. Demand Forecasting: An Evaluation of DODs Accuracy Metric and Navys Procedures

    Science.gov (United States)

    2016-06-01

    dataset ci = unit cost for item i fi = demand forecast for item i 28 ai = actual demand for item i A close look at fCIMIP metric reveals a...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT DEMAND FORECASTING : AN EVALUATION OF DOD’S ACCURACY...June 2016 3. REPORT TYPE AND DATES COVERED MBA professional report 4. TITLE AND SUBTITLE DEMAND FORECASTING : AN EVALUATION OF DOD’S ACCURACY

  6. Aerial Logistics Management for Carrier Onboard Delivery

    Science.gov (United States)

    2016-09-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS AERIAL LOGISTICS MANAGEMENT FOR CARRIER ONBOARD DELIVERY by Samuel L. Chen September 2016...AND SUBTITLE AERIAL LOGISTICS MANAGEMENT FOR CARRIER ONBOARD DELIVERY 5. FUNDING NUMBERS 6. AUTHOR(S) Samuel L. Chen 7. PERFORMING ORGANIZATION NAME(S...delivery (COD) is the use of aircraft to transport people and cargo from a forward logistics site (FLS) to a carrier strike group (CSG). The goal of

  7. Application of Two-Sided Matching to Internal Labor of the Hellenic Navy

    Science.gov (United States)

    2012-03-01

    Figure 7. The NIMP Algorithm¹³ The first memorable theoretical study of two-sided matching belongs to Milton Friedman and his 1955 article, “The Role...Military Personnel” (Master’s thesis, Naval Postgraduate School, Monterey, 2011). 15. Milton Friedman . “The Role of Government in Education,” in...Research, Cambridge, Massachusetts, June, 2009. Friedman , Milton . “The Role of Government in Education.” In Economics and the Public Interest, edited

  8. A Critical Analysis of U.S. Army Accessions through Socioeconomic Consideration between 1970 and 1984.

    Science.gov (United States)

    1985-06-01

    ADDRESS 10. PROGRAM ELEMENT, PROJECT. TASK AREA & WORK UNIT NUMBERS Naval Postgraduate School Monterey, California 93943 11. CONTROLLING OFFICE NAME AND...determine the sccioeccnomic representativeness of the Army’s enlistees in that iarticular year. In addition, the socioeconomic overviev of Republic cf...accomplished with the use of the Statistical Analysis System (SAS), an integrated computer system for data analysis. 32 TABLE 2 The States in Each District

  9. Water Tunnel Studies of Dynamic Wing Flap Effects

    Science.gov (United States)

    2016-06-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited WATER TUNNEL...Master’s Thesis 4. TITLE AND SUBTITLE WATER TUNNEL STUDIES OF DYNAMIC WING FLAP EFFECTS 5. FUNDING NUMBERS 6. AUTHOR(S) Edgar E. González 7. PERFORMING...ABSTRACT (maximum 200 words ) The flow features developing over a two-element NACA 0012 airfoil, with the rear portion serving as a trailing edge flap

  10. Discovery of IPV6 Router Interface Addresses via Heuristic Methods

    Science.gov (United States)

    2015-09-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS DISCOVERY OF IPV6 ROUTER INTERFACE ADDRESSES VIA HEURISTIC METHODS by Matthew D. Gray September...AND SUBTITLE DISCOVERY OF IPV6 ROUTER INTERFACE ADDRESSES VIA HEURISTIC METHODS 5. FUNDING NUMBERS CNS-1111445 6. AUTHOR(S) Matthew D. Gray 7...Internet Assigned Numbers Authority, there is continued pressure for widespread IPv6 adoption. Because the IPv6 address space is orders of magnitude

  11. Mucins CA 125, CA 19.9, CA 15.3 and TAG-72.3 as tumor markers in patients with lung cancer: comparison with CYFRA 21-1, CEA, SCC and NSE.

    Science.gov (United States)

    Molina, Rafael; Auge, Jose Maria; Escudero, Jose Miguel; Marrades, Ramon; Viñolas, Nuria; Carcereny, Emilio; Ramirez, Jose; Filella, Xavier

    2008-01-01

    Tumor marker serum levels were prospectively studied in 289 patients with suspected, but unconfirmed, lung cancer and in 513 patients with lung cancer [417 non-small cell lung cancer (NSCLC) patients and 96 small cell lung cancer (SCLC) patients]. In patients with benign disease, abnormal serum levels were found for the following tumor markers: CEA (in 6.6% of patients); CA 19.9 (6.2%); CA 125 (28.7%); NSE (0.7%); CYFRA (8.7%); TAG-72.3 (4.2%); SCC (3.5%), and CA 15.3 (3.5%). Excluding patients with renal failure or liver diseases, tumor marker specificity improved with abnormal levels in 0.5% for NSE, 0.9% for SCC, 2.8% for CEA, CA 15.3 and TAG-72.3, 3.8% for CA 19.9, 4.2% for CYFRA and 21.4% for CA 125. Excluding CA 125, one of the markers was abnormal in 15% of patients without malignancy. Tumor marker sensitivity was related to cancer histology and tumor extension. NSE had the highest sensitivity in SCLC and CYFRA and CEA in NSCLC. Significantly higher concentrations of CEA, SCC, CA 125, CA 15.3 and TAG-72.3 were found in NSCLC than in SCLC. Likewise, significantly higher CEA (p tumors. Using a combination of 3 tumor markers (CEA, CYFRA 21-1 in all histologies, SCC in squamous tumors and CA 15.3 in adenocarcinomas), a high sensitivity may be achieved in all histological types. Tumor markers may be useful in the histological differentiation of NSCLC and SCLC. Using specific criteria for the differentiation of SCLC and NSCLC, the sensitivity was 84.2 and 68.8%, the specificity was 93.8 and 99.7%, the positive predictive value was 98.3 and 98.5% and the negative predictive value was 57.7 and 93.3%, respectively. Copyright 2008 S. Karger AG, Basel.

  12. High temperature hydrogenation of CaC6

    International Nuclear Information System (INIS)

    Srinivas, G.; Howard, C.A.; Skipper, N.T.; Bennington, S.M.; Ellerby, M.

    2009-01-01

    The structure and superconducting properties of high temperature hydrogenated calcium-graphite intercalation compound, CaC 6 have been investigated using room temperature X-ray diffraction, and temperature and field dependence of magnetisation. It is found that the hydrogenation can only decompose the CaC 6 phase, and generate a mixture of CaH 2 and graphite as the final compound. The hydrogenation of CaC 6 also reveals a degradation of its superconducting properties. The experimental results are discussed in detail and it is found that the formation of stable CaH 2 and deintercalation are the main source for observed phase separation and suppression in superconductivity.

  13. Plasma membrane Ca2+-ATPase 4: interaction with constitutive nitric oxide synthases in human sperm and prostasomes which carry Ca2+/CaM-dependent serine kinase.

    Science.gov (United States)

    Andrews, Rachel E; Galileo, Deni S; Martin-DeLeon, Patricia A

    2015-11-01

    Deletion of the gene encoding the widely conserved plasma membrane calcium ATPase 4 (PMCA4), a major Ca(2+) efflux pump, leads to loss of sperm motility and male infertility in mice. PMCA4's partners in sperm and how its absence exerts its effect on fertility are unknown. We hypothesize that in sperm PMCA4 interacts with endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) which are rapidly activated by Ca(2+), and that these fertility-modulating proteins are present in prostasomes, which deliver them to sperm. We show that in human sperm PMCA4 is present on the acrosome, inner acrosomal membrane, posterior head, neck, midpiece and the proximal principal piece. PMCA4 localization showed inter- and intra-individual variation and was most abundant at the posterior head/neck junction, co-localizing with NOSs. Co-immunoprecipitations (Co-IP) revealed a close association of PMCA4 and the NOSs in Ca(2+) ionophore-treated sperm but much less so in uncapacitated untreated sperm. Fluorescence resonance energy transfer (FRET) showed a similar Ca(2+)-related association: PMCA4 and the NOSs are within 10 nm apart, and preferentially so in capacitated, compared with uncapacitated, sperm. FRET efficiencies varied, being significantly (P < 0.001) higher at high cytosolic Ca(2+) concentration ([Ca(2+)]c) in capacitated sperm than at low [Ca(2+)]c in uncapacitated sperm for the PMCA4-eNOS complex. These dynamic interactions were not seen for PMCA4-nNOS complexes, which had the highest FRET efficiencies. Further, along with Ca(2+)/CaM-dependent serine kinase (CASK), PMCA4 and the NOSs are present in the seminal plasma, specifically in prostasomes where Co-IP showed complexes similar to those in sperm. Finally, flow cytometry demonstrated that following co-incubation of sperm and seminal plasma, PMCA4 and the NOSs can be delivered in vitro to sperm via prostasomes. Our findings indicate that PMCA4 interacts simultaneously with the NOSs preferentially at

  14. Distinct roles of two ceramide synthases, CaLag1p and CaLac1p, in the morphogenesis of Candida albicans

    DEFF Research Database (Denmark)

    Cheon, Seon Ah; Bal, Jyotiranjan; Song, Yunkyoung

    2012-01-01

    p) and Lac1p (CaLac1p) are functionally distinct. Lack of CaLag1p, but not CaLac1p, caused severe defects in the growth and hyphal morphogenesis of C. albicans. Deletion of CaLAG1 decreased expression of the hypha-specific HWP1 and ECE1 genes. Moreover, overexpression of CaLAG1 induced pseudohyphal...... growth in this organism under non-hypha-inducing conditions, suggesting that CaLag1p is necessary for relaying signals to induce hypha-specific gene expression. Analysis of ceramide and sphingolipid composition revealed that CaLag1p predominantly synthesizes ceramides with C24:0/C26:0 fatty acid moieties...

  15. Assessment of the diagnostic value of combined determination of serum CA199 CA125 and CEA in patients with cancer of pancreas

    International Nuclear Information System (INIS)

    Wu Congshan; Liu Xugui

    2005-01-01

    Objective: To assess the diagnostic value of combined determination of serum CA199, CA125 and CEA for cancer of pancreas. Methods: Serum CA199, CA125 and CEA levels were detected with CLIA in 32 patients with cancer of pancreas and 36 controls. Results: Positive detection rate of CA199 in patients with cancer of pancreas was 90.6% (29/32). Positive rate for CA125 and CEA was 65.6% (21/32) and 46.9% (15/32) respectively. With combined determination of these 3 tumor markers, the positive rate was 96.9% (31/32). The mean content of serum CA199 after successful operation (32.5±8.4U/ml) was significantly lower than that before operation (840.2 ± 102.5U/ml) (P<0.01). Conclusion: Combined determination of CA199, CA125 and CEA would improve the detection rate of cancer of pancreas and post-operative changes of CA199 could be of prognostic value. (authors)

  16. Astragalus Granule Prevents Ca2+ Current Remodeling in Heart Failure by the Downregulation of CaMKII

    Directory of Open Access Journals (Sweden)

    Sinai Li

    2017-01-01

    Full Text Available Background. Astragalus was broadly used for treating heart failure (HF and arrhythmias in East Asia for thousands of years. Astragalus granule (AG, extracted from Astragalus, shows beneficial effect on the treatment of HF in clinical research. We hypothesized that administration of AG prevents the remodeling of L-type Ca2+ current (ICa-L in HF mice by the downregulation of Ca2+/calmodulin-dependent protein kinase II (CaMKII. Methods. HF mice were induced by thoracic aortic constriction (TAC. After 4 weeks of AG treatment, cardiac function and QT interval were evaluated. Single cardiac ventricular myocyte was then isolated and whole-cell patch clamp was used to record action potential (AP and ICa-L. The expressions of L-type calcium channel alpha 1C subunit (Cav1.2, CaMKII, and phosphorylated protein kinase A (p-PKA were examined by western blot. Results. The failing heart manifested distinct electrical remodeling including prolonged repolarization time and altered ICa-L kinetics. AG treatment attenuated this electrical remodeling, supported by AG-related shortened repolarization time, decreased peak ICa-L, accelerated ICa-L inactivation, and positive frequency-dependent ICa-L facilitation. In addition, AG treatment suppressed the overexpression of CaMKII, but not p-PKA, in the failing heart. Conclusion. AG treatment protected the failing heart against electrical remodeling and ICa-L remodeling by downregulating CaMKII.

  17. Ca-Dependent Folding of Human Calumenin

    Science.gov (United States)

    Mazzorana, Marco; Hussain, Rohanah; Sorensen, Thomas

    2016-01-01

    Human calumenin (hCALU) is a six EF-hand protein belonging to the CREC family. As other members of the family, it is localized in the secretory pathway and regulates the activity of SERCA2a and of the ryanodine receptor in the endoplasmic reticulum (ER). We have studied the effects of Ca2+ binding to the protein and found it to attain a more compact structure upon ion binding. Circular Dichroism (CD) measurements suggest a major rearrangement of the protein secondary structure, which reversibly switches from disordered at low Ca2+ concentrations to predominantly alpha-helical when Ca2+ is added. SAXS experiments confirm the transition from an unfolded to a compact structure, which matches the structural prediction of a trilobal fold. Overall our experiments suggest that calumenin is a Ca2+ sensor, which folds into a compact structure, capable of interacting with its molecular partners, when Ca2+ concentration within the ER reaches the millimolar range. PMID:26991433

  18. Ca isotope fractionation and Sr/Ca partitioning associated with anhydrite formation at mid-ocean ridge hydrothermal systems: An experimental approach

    Science.gov (United States)

    Syverson, D. D.; Scheuermann, P.; Pester, N. J.; Higgins, J. A.; Seyfried, W. E., Jr.

    2016-12-01

    The elemental and isotopic mass balance of Ca and Sr between seawater and basalt at mid-ocean ridge (MOR) hydrothermal systems is an integrated reflection of the various physiochemical processes, which induce chemical exchange, in the subseafloor. Specifically, the processes of anhydrite precipitation and recrystallization are recognized to be important controls on governing the Ca and Sr elemental and isotope compositions of high temperature vent fluids, however, few experimental data exist to constrain these geochemical effects. Thus, to better understand the associated Sr/Ca partitioning and Ca isotope fractionation and rate of exchange between anhydrite and dissolved constituents, anhydrite precipitation and recrystallization experiments were performed at 175, 250, and 350°C and 500 bar at chemical conditions indicative of active MOR hydrothermal systems. The experimental data suggest that upon entrainment of seawater into MOR hydrothermal systems, anhydrite will precipitate rapidly and discriminate against the heavy isotopes of Ca (Δ44/40Ca(Anh-Fluid) = -0.68 - -0.25 ‰), whereas Sr/Ca partitioning depends on the saturation state of the evolving hydrothermal fluid with respect to anhydrite at each PTX (KD(Anh-Fluid) = 1.24 - 0.55). Coupling experimental constraints with the temperature gradient inferred for high temperature MOR hydrothermal systems in the oceanic crust, data suggest that the Ca isotope and Sr elemental composition of anhydrite formed near the seafloor will be influenced by disequilibrium effects, while, at higher temperatures further into the oceanic crust, anhydrite will be representative of equilibrium Sr/Ca partitioning and Ca isotope fractionation conditions. These experimental observations are consistent with analyzed Sr/Ca and Ca isotope compositions of anhydrites and vent fluids sampled from modern MOR hydrothermal systems1,2 and can be used to further constrain the geochemical effects of hydrothermal circulation in the oceanic crust

  19. Usefulness of CA 130 kit based on IRMA

    International Nuclear Information System (INIS)

    Fujii, Takashi; Kimura, Yoshiko; Ata, Mariko; Miyagawa, Naoko; Iio, Atsushi; Hamamoto, Ken

    1988-01-01

    Immunoradiometric assay for CA 130 was fundamentally and clinically evaluated using a commercially available D-7111 kit. Incubation time was 4 hr with the present CA 133 kit as compared with 16 - 24 hr with conventional CA 125 kit. Laboratory performance of CA 130 kit was satisfactory for standard curve, reproducibility, and recovery test. There was well correlation between the present CA 130 kit and CA 125 kit (r = 0.931). The concentration of CA 130 in the serum was significantly higher in healthy women than men (17.3 +- 10.5 U/ml vs 9.6 +- 5.1 U/ml). Serum CA 130 levels tended to decrease with aging, regardless of sex. These levels were changeable with menstrual cycle ; i.e., these were significantly higher during menstrual phase (24.2 +- 9.0 U/ml) and significantly lower during ovulatory phase (10.9 +- 2.4 U/ml) and during menopause (12.1 +- 3.4 U/ml). Cut off serum CA 130 levels were defined as 20 U/ml for men and 38 U/ml for women. Positive rate for CA 130 was the highest in cases of ovarian cancer (80 %), followed by endometrial cancer (50 %), pancreatic cancer (47 %), benign ovarian tumor (44 %), and lung cancer (39 %). (Namekawa, K.)

  20. Association of the PPP3CA c.249G>A variant with clinical outcomes of tacrolimus-based therapy in kidney transplant recipients

    Directory of Open Access Journals (Sweden)

    Salgado PC

    2017-03-01

    Full Text Available Patricia C Salgado,1 Fabiana DV Genvigir,1 Claudia R Felipe,2 Helio Tedesco-Silva Jr,2 Jose O Medina-Pestana,2 Sonia Q Doi,3 Mario H Hirata,1 Rosario DC Hirata1 1Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of Sao Paulo, 2Division of Nephrology, Hospital do Rim, Federal University of Sao Paulo, Sao Paulo, Brazil; 3School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA Background: The effects of genetic variants related to the pharmacodynamic mechanisms of immunosuppressive drugs on their therapeutic efficacy and safety have been poorly explored. This study was performed to investigate the influence of the PPP3CA c.249G>A variant on the clinical outcomes of kidney transplant recipients. Patients and methods: A total of 148 Brazilian patients received tacrolimus (TAC-based immunosuppressive therapy for 90 days post-kidney transplantation. The PPP3CA rs3730251 (c.249G>A polymorphism was determined by real-time polymerase chain reaction. Single-nucleotide polymorphism (SNP data for CYP3A5 rs776746 (CYP3A5*3C; g.6986A>G were used to eliminate the confounding effects of this variant. Results: The PPP3CA c.249G>A SNP did not influence early TAC exposure, renal function, or other laboratory parameters, including levels of urea, creatinine, glucose, and lipids, and blood counts. This variant also did not account for the cumulative incidence of biopsy-confirmed acute rejection or delayed graft function. Regarding adverse events, PPP3CA c.249A allele carriers initially had a 3.05-fold increased probability of treatment-induced blood and lymphatic system disorders compared with c.249GG genotype individuals (95% confidence interval: 1.10–8.48, p=0.032. However, this result was not maintained after adjusting for body weight and CYP3A5*3C SNP status (p=0.086. Conclusion: The PPP3CA c.249G>A variant does not influence the clinical outcomes of Brazilian patients in the