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Sample records for schizophrenia research forum

  1. EUFOREA Rhinology Research Forum 2016

    DEFF Research Database (Denmark)

    Hellings, P W; Akdis, C A; Bachert, C

    2017-01-01

    The first European Rhinology Research Forum organized by the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) was held in the Royal Academy of Medicine in Brussels on 17th and 18th November 2016, in collaboration with the European Rhinologic Society (ERS......) and the Global Allergy and Asthma European Network (GA2LEN). One hundred and thirty participants (medical doctors from different specialties, researchers, as well as patients and industry representatives) from 27 countries took part in the multiple perspective discussions including brainstorming sessions on care...... pathways and research needs in rhinitis and rhinosinusitis. The debates started with an overview of the current state of the art, including weaknesses and strengths of the current practices, followed by the identification of essential research needs, thoroughly integrated in the context of Precision...

  2. Forum Theater’s potential as a Research Tool

    Directory of Open Access Journals (Sweden)

    Andrea Calsamiglia Madurga

    2016-03-01

    Full Text Available We present a theoretical and epistemological reflection on Forum Theater’s potential as a Research Tool. Our presence on social action and research has led us to a double reflection on qualitative research’s limitations on the affect studies and the Forum Theater’s potential as a research tool to tackle research about affects. After some specific experiences in action research (qualitative research on romantic love and gender violence, and the creation process of the Forum Theater “Is it a joke?”, we explore Forum Theatre’s possibilities as a research tool in the feminist epistemology framework.

  3. Where now for schizophrenia research?

    Science.gov (United States)

    Nutt, David J; Need, Anna C

    2014-08-01

    Schizophrenia continues to pose a serious challenge to neuroscience and psychiatry as well as to health care systems and to the patients and families who suffer this terrible and disabling illness. Major developments in the past few months in both genetics and drug development oblige us to consider novel drug discovery tactics for future schizophrenia research. Here we review what we consider to be the key issues and some suggested solutions. Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

  4. Practical guidelines for qualitative research using online forums.

    Science.gov (United States)

    Im, Eun-Ok; Chee, Wonshik

    2012-11-01

    With an increasing number of Internet research in general, the number of qualitative Internet studies has recently increased. Online forums are one of the most frequently used qualitative Internet research methods. Despite an increasing number of online forum studies, very few articles have been written to provide practical guidelines to conduct an online forum as a qualitative research method. In this article, practical guidelines in using an online forum as a qualitative research method are proposed based on three previous online forum studies. First, the three studies are concisely described. Practical guidelines are proposed based on nine idea categories related to issues in the three studies: (a) a fit with research purpose and questions, (b) logistics, (c) electronic versus conventional informed consent process, (d) structure and functionality of online forums, (e) interdisciplinary team, (f) screening methods, (g) languages, (h) data analysis methods, and (i) getting participants' feedback.

  5. Researchers Find a Mechanism for Schizophrenia

    Science.gov (United States)

    ... issue Health Capsule Researchers Find a Mechanism for Schizophrenia En español Send us your comments Scientists uncovered a mechanism behind genetic variations previously linked to schizophrenia. The findings may lead to new clinical approaches. ...

  6. Global Forum for Health Research 2008-2009 | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Since its foundation in 1998, the Global Forum for Health Research (GFHR) has sought to focus greater attention and resources on research that will improve the health of the poor, marginalized and disadvantaged. The Forum has also become an authoritative and independent source of reliable data, practical tools and ...

  7. Competition, Regulation and Development Research Forum ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... Forum : Competition and Regulatory Implementation Issues in Developing Countries ... create challenges that influence the operation of regulatory institutions. ... IWRA/IDRC webinar on climate change and adaptive water management.

  8. Economic Research Forum - Core Support 2012-2014 | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The Economic Research Forum (ERF) is a Cairo-based regional economics ... resource for researchers, publishing The Middle East Development Journal, and ... long-term climate action to reduce social inequality, promote greater gender ...

  9. Highlights from the Biennial International Congress on Schizophrenia Research (ICOSR), April 21-25, 2013.

    Science.gov (United States)

    Curley, Allison A; Fisher, Helen L

    2013-01-01

    The 2013 International Congress on Schizophrenia Research, held in Orlando Grande Lakes, Florida, attracted over 1,000 attendees to the JW Marriott Hotel from 21-25 April 2013, not to mention the satellite meetings on cognition and the schizophrenia prodrome. With thanks to the Schizophrenia Research Forum (www.schizophreniaforum.org), a project of the Brain and Behavior Research Foundation, we bring you the following report on the Congress' sessions concerning DSM-5/ICD-11 and the psychosis continuum. We also want to thank Congress directors Carol Tamminga and Chuck Schulz, as well as meeting staff Dorothy Denton and Cristan Tamminga, for their gracious assistance.

  10. A review of schizophrenia research in malaysia.

    Science.gov (United States)

    Chee, K Y; Salina, A A

    2014-08-01

    Research in schizophrenia has advanced tremendously. One hundred and seventy five articles related to Schizophrenia were found from a search through a database dedicated to indexing all original data relevant to medicine published in Malaysia between the years 2000-2013. This project aims to examine published research articles, in local and international journals in order to provide a glimpse of the research interest in Malaysia with regards to schizophrenia. Single case study, case series report, reviews and registry reports were not included in this review. Medication trial, unless it concerned a wider scope of psychopharmacology was also excluded from this review. A total of 105 articles were included in this review. Despite numerous genetics studies conducted and published, a definitive conclusion on the aetiology or mechanism underlying schizophrenia remains elusive. The National Mental Health - Schizophrenia Registry (NMHR) proved to be an important platform for many studies and publications. Studies stemmed from NMHR have provided significant insight into the baseline characteristic of patients with schizophrenia, pathway to care, and outcomes of the illness. International and regional collaborations have also encouraged important work involving stigma and discrimination in schizophrenia. Ministry of Health's hospitals (MOH) are the main research sites in the country with regards to schizophrenia research. Numbers of schizophrenia research are still low in relation to the number of universities and hospitals in the country. Some of the weaknesses include duplication of studies, over-emphasising clinical trials and ignoring basic clinical research, and the lack of publications in international and regional journals.

  11. Visions for Horizon 2020 from Copenhagen Research Forum

    DEFF Research Database (Denmark)

    Brenneche, Nicolaj Tofte; Højgaard, Liselotte

    2012-01-01

    In January 2012, the Copenhagen Research Forum (CRF) gathered 80 European scientists to discuss the societal chal-lenges to be addressed by Horizon 2020, the next framework programme for European research and innovation, and consider how research could contribute the best solutions. This EFP brie...

  12. Glutamate in schizophrenia: clinical and research implications.

    Science.gov (United States)

    Goff, D C; Wine, L

    1997-10-30

    The excitatory amino acids, glutamate and aspartate, are of interest to schizophrenia research because of their roles in neurodevelopment, neurotoxicity and neurotransmission. Recent evidence suggests that densities of glutamatergic receptors and the ratios of subunits composing these receptors may be altered in schizophrenia, although it is unclear whether these changes are primary or compensatory. Agents acting at the phencyclidine binding site of the NMDA receptor produce symptoms of schizophrenia in normal subjects, and precipitate relapse in patients with schizophrenia. The improvement of negative symptoms with agents acting at the glycine modulatory site of the NMDA receptor, as well as preliminary evidence that clozapine may differ from conventional neuroleptic agents in its effects on glutamatergic systems, suggest that clinical implications may follow from this model. While geriatric patients may be at increased risk for glutamate-mediated neurotoxicity, very little is known about the specific relevance of this model to geriatric patients with schizophrenia.

  13. The Written Literacy Forum: Combining Research and Practice.

    Science.gov (United States)

    Clark, Christopher M.; Florio, Susan

    1983-01-01

    Writing teachers and researchers collaborate in the Written Literacy Forum at Michigan State University to: (1) heighten teachers' awareness of the complexity of writing; (2) stimulate discussion across grade levels; and (3) focus research on areas concerning teachers. Discussion formats and inservice activities are described, and materials…

  14. Meeting report: Global vaccine and immunization research forum.

    Science.gov (United States)

    Ford, Andrew Q; Touchette, Nancy; Fenton Hall, B; Hwang, Angela; Hombach, Joachim

    2018-02-08

    Building on the success of the first Global Vaccine and Immunization Research Forum (GVIRF), the World Health Organization, the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health in the United States of America, and the Bill & Melinda Gates Foundation convened the second GVIRF in March 2016. Leading scientists, vaccine developers, and public health officials from around the world discussed scientific advances and innovative technologies to design and deliver vaccines as well as novel tools and approaches to increase the uptake of vaccines throughout the world. This report summarizes the discussions and conclusions from the forum participants. Copyright © 2018.

  15. An online forum as a qualitative research method: practical issues.

    Science.gov (United States)

    Im, Eun-Ok; Chee, Wonshik

    2006-01-01

    Despite the positive aspects of online forums as a qualitative research method, very little is known on the practical issues involved in using online forums for data collection, especially for a qualitative research project. The aim of this study was to describe the practical issues encountered in implementing an online forum as a qualitative component of a larger study on cancer pain experience. Throughout the study process, the research staff recorded issues ranging from minor technical problems to serious ethical dilemmas as they arose and wrote memos about them. The memos and written records of the discussions were reviewed and analyzed using content analysis. Two practical issues related to credibility were identified: (a) a high response and retention rate and (b) automatic transcripts. An issue related to dependability was the participants' forgetfulness. The issues related to confirmability were difficulties in theoretical saturation and unstandardized computer and Internet jargon. A security issue related to hacking attempts was noted as well. The analysis of these issues suggests several implications for future researchers who want to use online forums as a qualitative data collection method.

  16. Cambodia Development Research Forum II | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Cambodia's research community is still rebuilding from decades of turmoil that included civil war and a period of ethnic and intellectual cleansing under the Khmer Rouge. Its development research community remains dispersed and unconnected, though there are pockets of strong capacity. IDRC was one of the first ...

  17. Proceedings of Nova Scotia's 2006 energy research and development forum

    International Nuclear Information System (INIS)

    2006-01-01

    The Nova Scotia 2006 energy research and development forum provided a venue for experts from industry, research institutions and government to discuss how research and development will shape the future of energy in the province. The forum was divided into 3 sessions: (1) building knowledge about the marine environment, (2) building knowledge about geoscience, and (3) building knowledge about sustainable energy. A wide ranges of issues related to the Nova Scotia region included whale identification; fisheries mapping; the commercialization of hydrocarbon discoveries; carbon capture and storage and petroleum system analysis and prospect evaluation. Keynote addresses were presented on produced water in Norway; deepwater exploration in Morocco; renewable energy and Canada's role as an energy superpower. The conference featured more than 57 presentations, of which 4 have been catalogued separately for inclusion in this database. refs., tabs., figs

  18. [Schizophrenia and informed consent to research].

    Science.gov (United States)

    Fovet, T; Amad, A; Thomas, P; Jardri, R

    2015-10-01

    Informed consent to research remains a complex issue, while sometimes staying difficult to obtain, even in the general population. This problem may be maximized with patients suffering from schizophrenia. This paper summarizes available data in the literature about informed consent for research involving patients suffering from schizophrenia. Medline and Google Scholar searches were conducted using the following MESH terms: schizophrenia, informed consent and research. Studies using dedicated standardized scales (e.g. MacCAT-CR) revealed a decrease in the capacity to consent of patients with schizophrenia when compared with healthy individuals. Keeping in mind that schizophrenia is an heterogeneous disorder, patients with the lowest insight as well as those with the most severe cognitive symptoms appeared more impaired in their capacity to consent. Such a poor capacity to understand and consent to trials was shown linked with alterations in decision-making. For these specific patients, interventions may be set up to increase their capacity to consent. Various strategies were proposed: enhanced consent forms, extended discussion, test/feedback method or multimedia interventions. Among them, interventions relying on communication and the growing field of information technologies (e.g. web-based tools) seem promising. Finally, associations grouping families and patients (like the French Association UNAFAM) may facilitate the involvement of patients in research programs with safer conditions. Patients suffering from schizophrenia appear able to consent to research programs when suitable interventions are proposed. Further studies are now needed to optimize and individualize such interventions. Copyright © 2014 L’Encéphale, Paris. Published by Elsevier Masson SAS. All rights reserved.

  19. Basic Solar Energy Research in Japan (2011 EFRC Forum)

    International Nuclear Information System (INIS)

    Domen, Kazunari

    2011-01-01

    Kazunari Domen, Chemical System Engineering Professor at the University of Tokyo, was the second speaker in the May 26, 2011 EFRC Forum session, 'Global Perspectives on Frontiers in Energy Research.' In his presentation, Professor Domen talked about basic solar energy research in Japan. The 2011 EFRC Summit and Forum brought together the EFRC community and science and policy leaders from universities, national laboratories, industry and government to discuss 'Science for our Nation's Energy Future.' In August 2009, the Office of Science established 46 Energy Frontier Research Centers. The EFRCs are collaborative research efforts intended to accelerate high-risk, high-reward fundamental research, the scientific basis for transformative energy technologies of the future. These Centers involve universities, national laboratories, nonprofit organizations, and for-profit firms, singly or in partnerships, selected by scientific peer review. They are funded at $2 to $5 million per year for a total planned DOE commitment of $777 million over the initial five-year award period, pending Congressional appropriations. These integrated, multi-investigator Centers are conducting fundamental research focusing on one or more of several 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The purpose of the EFRCs is to integrate the talents and expertise of leading scientists in a setting designed to accelerate research that transforms the future of energy and the environment.

  20. NASA-HBCU Space Science and Engineering Research Forum Proceedings

    International Nuclear Information System (INIS)

    Sanders, Y.D.; Freeman, Y.B.; George, M.C.

    1989-01-01

    The proceedings of the Historically Black Colleges and Universities (HBCU) forum are presented. A wide range of research topics from plant science to space science and related academic areas was covered. The sessions were divided into the following subject areas: Life science; Mathematical modeling, image processing, pattern recognition, and algorithms; Microgravity processing, space utilization and application; Physical science and chemistry; Research and training programs; Space science (astronomy, planetary science, asteroids, moon); Space technology (engineering, structures and systems for application in space); Space technology (physics of materials and systems for space applications); and Technology (materials, techniques, measurements)

  1. Visualization analysis of author collaborations in schizophrenia research

    OpenAIRE

    Wu, Ying; Duan, Zhiguang

    2015-01-01

    Background Schizophrenia is a serious mental illness that levies a heavy medical toll and cost burden throughout the world. Scientific collaborations are necessary for progress in psychiatric research. However, there have been few publications on scientific collaborations in schizophrenia. The aim of this study was to investigate the extent of author collaborations in schizophrenia research. Methods This study used 58,107 records on schizophrenia from 2003 to 2012 which were downloaded from S...

  2. Discussion forum for researchers in nuclear geology. Programme and abstracts

    International Nuclear Information System (INIS)

    Brynard, H.J.

    1986-11-01

    The Atomic Energy Corporation of SA Ltd (AEC) sponsors research in nuclear geology at several South African universities with a view to delineating target areas for uranium prospecting by mining companies. In order to ensure the efficient co-ordination of this research an annual meeting is held where sponsored researchers and other organizations report on their progress during the year. This ensures valuable cross-pollination of ideas, and an input from the mining industry is gained as to which direction future research should take. The results of the researchers reported on at these meetings is not necessarily complete and the abstracts in this volume should therefore not be regarded as conclusive. In this discussion forum uranium in granites and uranium in sedimentory deposits are covered. The geochemical anomalies of uranium as well as the geohydrology and its application in defining uranium are also discussed

  3. IS Research and Policy: Notes From the 2015 ICIS Senior Scholar’s Forum

    DEFF Research Database (Denmark)

    Niederman, Fred; Applegate, Lynda; Beck, Roman

    2017-01-01

    Based on the International Conference on Information Systems’ (ICIS) 2015 senior scholars’ forum, we provide insights on the role and opportunities of IS researchers in shaping policy.......Based on the International Conference on Information Systems’ (ICIS) 2015 senior scholars’ forum, we provide insights on the role and opportunities of IS researchers in shaping policy....

  4. Visualization analysis of author collaborations in schizophrenia research.

    Science.gov (United States)

    Wu, Ying; Duan, Zhiguang

    2015-02-19

    Schizophrenia is a serious mental illness that levies a heavy medical toll and cost burden throughout the world. Scientific collaborations are necessary for progress in psychiatric research. However, there have been few publications on scientific collaborations in schizophrenia. The aim of this study was to investigate the extent of author collaborations in schizophrenia research. This study used 58,107 records on schizophrenia from 2003 to 2012 which were downloaded from Science Citation Index Expanded (SCI Expanded) via Web of Science. CiteSpace III, an information visualization and analysis software, was used to make a visual analysis. Collaborative author networks within the field of schizophrenia were determined using published documents. We found that external author collaboration networks were more scattered while potential author collaboration networks were more compact. Results from hierarchical clustering analysis showed that the main collaborative field was genetic research in schizophrenia. Based on the results, authors belonging to different institutions and in different countries should be encouraged to collaborate in schizophrenia research. This will help researchers focus their studies on key issues, and allow each other to offer reasonable suggestions for making polices and providing scientific evidence to effectively diagnose, prevent, and cure schizophrenia.

  5. ENRICH Forum: Ethical aNd Regulatory Issues in Cancer ResearcH

    Science.gov (United States)

    ENRICH Forum: Ethical aNd Regulatory Issues in Cancer ResearcH, designed to stimulate dialogue on ethical and regulatory issues in cancer research and promote awareness of developing policies and best practices.

  6. SGCI Forum: Effective public-private partnerships in research and ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    22 nov. 2017 ... Senior staff of science granting councils (SGCs) and other science, technology, and innovation actors in sub-Saharan Africa will gather at the Annual Forum of the Science Granting Councils Initiative (SGCI) to share evidence, experiences, and best practices, and to develop interventions in strategic areas ...

  7. 77 FR 36606 - Pipeline Safety: Government/Industry Pipeline Research and Development Forum, Public Meeting

    Science.gov (United States)

    2012-06-19

    ...: Threat Prevention --Working Group 2: Leak Detection/Mitigation & Storage --Working Group 3: Anomaly... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket ID PHMSA-2012-0146] Pipeline Safety: Government/Industry Pipeline Research and Development Forum, Public...

  8. Introduction to the AJA research forum on aging and hearing: mechanisms and effects.

    Science.gov (United States)

    Paglialonga, Alessia; Grandori, Ferdinando

    2013-12-01

    PURPOSE This Research Forum, "Aging and Hearing: Mechanisms and Effects," highlights 6 contributions presented at the 2nd International Conference on Adult Hearing Screening (AHS 2012), held in Cernobbio (Lake Como, Italy) in June 2012. Overall, the articles in this Research Forum give insight into the causes, mechanisms, and consequences of auditory dysfunctions in adults, with particular focus on their implications for screening, assessment, and intervention.

  9. Proceedings of the flat-plate solar array project research forum on photovoltaic metallization systems

    Energy Technology Data Exchange (ETDEWEB)

    None

    1983-11-15

    A Photovoltaic Metallization Research Forum, under the sponsorship of the Jet Propulsion Laboratory's Flat-Plate Solar Array Project and the US Department of Energy, was held March 16-18, 1983 at Pine Mountain, Georgia. The Forum consisted of five sessions, covering (1) the current status of metallization systems, (2) system design, (3) thick-film metallization, (4) advanced techniques and (5) future metallization challenges. Twenty-three papers were presented.

  10. Studies in Teaching 1999 Research Digest. Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, December 1999).

    Science.gov (United States)

    McCoy, Leah P., Ed.

    This publication presents a collection of research projects presented at the Annual Research Forum at Wake Forest University: "The Use of Group Work as an Effective Teaching Technique in Lower Level Spanish Classes" (James Blackburn); "What Are the Real Factors behind Student Motivation?" (Matthew Grey Burdick); "Can…

  11. The Written Literacy Forum: An Analysis of Teacher/Researcher Collaboration.

    Science.gov (United States)

    Florio-Ruane, Susan

    1990-01-01

    Describes the Written Literacy Forum, a collaborative research effort between Michigan State University's Institute for Research on Teaching and the East Lansing, Michigan Public Schools, which attempted to identify ways that research on writing could be applied to instructional problems. Depicts the first year's experience and offers sample…

  12. EAWAG Forum Chriesbach - A new building for aquatic research

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-02-15

    This brochure describes the 'Forum Chriesbach' - a new building for Swiss Federal Institute of Aquatic Science and Technology EAWAG that features a facade of blue glass panels that block the sun's rays in summer and let them through in winter, a highly insulating structural cladding and a ventilation system which almost needs no heating and active cooling. A photovoltaic system, which covers one third of the building's electricity requirements, a glass-roofed atrium which brings light into the building and provides night-time cooling during summer is also described. An extensively greened roof which retains rainwater, rainwater-flushed toilets with separate collection of urine, the use of environmentally compatible materials and a staff canteen with an attractive selection of organic menus are noted. The construction of the institute is briefly documented and its energy systems are described as are the materials used in its construction.

  13. Development of a productive research culture in emergency medicine: Report of the outcomes of a research forum.

    Science.gov (United States)

    Taylor, David McD; Cohen, Donna R; Epstein, Joseph; Freeman, Peter; Gosbell, Andrew D; Judkins, Simon; Mowatt, Elizabeth J M; O'Reilly, Gerard M; Vinen, John

    2016-02-01

    In recent years, the Australasian College for Emergency Medicine (ACEM) has increasingly focused on the need for high-quality research in emergency medicine (EM). One important initiative was the establishment of the ACEM Foundation, which among other responsibilities, is required to support clinical research through the provision of research funding and other measures. In February 2015, the Foundation held a Research Forum that was attended by the leading EM researchers from Australasia. The Forum aimed to determine how a productive research culture could be developed within the ACEM. Nine key objectives were determined including that research should be a core business of the ACEM and a core activity of the EM workforce, and that EM research should be sustainable and adequately supported. This report describes the background and conduct of the Forum, its recommendations and the way in which they could be implemented. © 2015 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine.

  14. The Electronic Data Methods (EDM) forum for comparative effectiveness research (CER).

    Science.gov (United States)

    Holve, Erin; Segal, Courtney; Lopez, Marianne Hamilton; Rein, Alison; Johnson, Beth H

    2012-07-01

    AcademyHealth convened the Electronic Data Methods (EDM) Forum to collect, synthesize, and share lessons from eleven projects that are building infrastructure and using electronic clinical data for comparative effectiveness research (CER) and patient-centered outcomes research (PCOR). This paper provides a brief review of participating projects and provides a framework of common challenges. EDM Forum staff conducted a text review of relevant grant programs' funding opportunity announcements; projects' research plans; and available information on projects' websites. Additional information was obtained from presentations provided by each project; phone calls with project principal investigators, affiliated partners, and staff from the Agency for Healthcare Research and Quality (AHRQ); and six site visits. Projects participating in the EDM Forum are building infrastructure and developing innovative strategies to address a set of methodological, and data and informatics challenges, here identified in a common framework. The eleven networks represent more than 20 states and include a range of partnership models. Projects vary substantially in size, from 11,000 to more than 7.5 million individuals. Nearly all of the AHRQ priority populations and conditions are addressed. In partnership with the projects, the EDM Forum is focused on identifying and sharing lessons learned to advance the national dialogue on the use of electronic clinical data to conduct CER and PCOR. These efforts have the shared goal of addressing challenges in traditional research studies and data sources, and aim to build infrastructure and generate evidence to support a learning health care system that can improve patient outcomes.

  15. Arthritis Research and Education in Nursing and Allied Health: A Forum.

    Science.gov (United States)

    Public Health Service (DHHS), Rockville, MD.

    A summary of proceedings of the Forum on Arthritis Research and Education in Nursing and Allied Health is presented. The keynote address, "The Burden of Arthritis," by Dorothy P. Rice, provides data collected by the National Center for Health Statistics on the prevalence of arthritis, the burden it imposes, and the volume, type, and cost…

  16. Proceedings of the Flat-Plate Solar Array Project Research Forum on Photovoltaic Metallization Systems

    Science.gov (United States)

    1983-01-01

    A photovoltaic Metallization Research forum, under the sponsorship of the Flat-Plate Solar Array Project consisted of five sessions, covering: (1) the current status of metallization systems, (2) system design, (3) thick-film metallization, (4) advanced techniques, and (5) future metallization challenges.

  17. EUFOREA Rhinology Research Forum 2016: report of the brainstorming sessions on needs and priorities in rhinitis and rhinosinusitis

    NARCIS (Netherlands)

    Hellings, P. W.; Akdis, C. A.; Bachert, C.; Bousquet, J.; Pugin, B.; Adriaensen, G.; Advani, R.; Agache, I.; Anjo, C.; Anmolsingh, R.; Annoni, E.; Bieber, T.; Bizaki, A.; Braverman, I.; Callebaut, I.; Castillo Vizuete, J. A.; Chalermwatanachai, T.; Chmielewski, R.; Cingi, C.; Cools, L.; Coppije, C.; Cornet, M. E.; de Boeck, I.; de Corso, E.; de Greve, G.; Doulaptsi, M.; Edmiston, R.; Erskine, S.; Gevaert, E.; Gevaert, P.; Golebski, K.; Hopkins, C.; Hox, V.; Jaeggi, C.; Joos, G.; Khwaja, S.; Kjeldsen, A.; Klimek, L.; Koennecke, M.; Kortekaas Krohn, I.; Krysko, O.; Kumar, B. N.; Langdon, C.; Lange, B.; Lekakis, G.; Levie, P.; Lourijsen, E.; Lund, V. J.; Martens, K.; Mő Sges, R.; Mullol, J.; Nyembue, T. D.; Palkonen, S.; Philpott, C.; Pimentel, J.; Poirrier, A.; Pratas, A. C.; Prokopakis, E.; Pujols, L.; Rombaux, P.; Schmidt-Weber, C.; Segboer, C.; Spacova, I.; Staikuniene, J.; Steelant, B.; Steinsvik, E. A.; Teufelberger, A.; van Gerven, L.; van Gool, K.; Verbrugge, R.; Verhaeghe, B.; Virkkula, P.; Vlaminck, S.; Vries-Uss, E.; Wagenmann, M.; Zuberbier, T.; Seys, S. F.; Fokkens, W. J.

    2017-01-01

    The first European Rhinology Research Forum organized by the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) was held in the Royal Academy of Medicine in Brussels on 17th and 18th November 2016, in collaboration with the European Rhinologic Society (ERS) and the

  18. LiLEDDA: A Six-Step Forum-Based Netnographic Research Method for Nursing Science

    Directory of Open Access Journals (Sweden)

    MARTIN SALZMANN-ERIKSON

    2012-01-01

    Full Text Available Internet research methods in nursing science are less developed than in other sciences. We choose to present an approach to conducting nursing research on an internet-based forum. This paper presents LiLEDDA, a six-step forum-based netnographic research method for nursing science. The steps consist of: 1. Literature review and identification of the research question(s; 2. Locating the field(s online; 3. Ethical considerations; 4. Data gathering; 5. Data analysis and interpretation; and 6. Abstractions and trustworthiness. Traditional research approaches are limiting when studying non-normative and non-mainstream life-worlds and their cultures. We argue that it is timely to develop more up-to-date research methods and study designs applicable to nursing science that reflect social developments and human living conditions that tend to be increasingly online-based.

  19. Global Vaccine and Immunization Research Forum: Opportunities and challenges in vaccine discovery, development, and delivery.

    Science.gov (United States)

    Ford, Andrew Q; Touchette, Nancy; Hall, B Fenton; Hwang, Angela; Hombach, Joachim

    2016-03-18

    The World Health Organization, the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, and the Bill & Melinda Gates Foundation convened the first Global Vaccine and Immunization Research Forum (GVIRF) in March 2014. This first GVIRF aimed to track recent progress of the Global Vaccine Action Plan research and development agenda, identify opportunities and challenges, promote partnerships in vaccine research, and facilitate the inclusion of all stakeholders in vaccine research and development. Leading scientists, vaccine developers, and public health officials from around the world discussed scientific and technical challenges in vaccine development, research to improve the impact of immunization, and regulatory issues. This report summarizes the discussions and conclusions from the forum participants. Copyright © 2016. Published by Elsevier Ltd.. All rights reserved.

  20. Studies in Teaching. 1995 Research Digest. Papers Presented at the Annual Research Forum (Winston-Salem, North Carolina, December 1995).

    Science.gov (United States)

    McCoy, Leah P., Ed.

    This is a collection of papers reporting student research projects at the Annual Research Forum, Department of Education, Wake Forest University (North Carolina). They include: "Student Interest in Studying World History in Relation to Current Events" (Conan Arthur); "Perceptions of High School Student Athletes and Athletics"…

  1. Pain Research Forum: Application of Scientific Social Media Frameworks in Neuroscience

    Directory of Open Access Journals (Sweden)

    Sudeshna eDas

    2014-03-01

    Full Text Available Background: Social media has the potential to accelerate the pace of biomedical research through online collaboration, discussions and faster sharing of information. Focused web-based scientific social collaboratories such as the Alzheimer Research Forum have been successful in engaging scientists in open discussions of the latest research and identifying gaps in knowledge. However, until recently, tools to rapidly create such communities and provide high-bandwidth information exchange between collaboratories in related fields did not exist. Methods: We have addressed this need by constructing a reusable framework to build online biomedical communities, based on Drupal, an open-source content management system. The framework incorporates elements of Semantic Web technology combined with social media. Here we present, as an exemplar of a web community built on our framework, the Pain Research Forum (PRF. PRF is a community of chronic pain researchers, established with the goal of fostering collaboration and communication among pain researchers. Results: Launched in 2011, PRF has over 1,300 registered members with permission to submit content. It currently hosts over 150 topical news articles on research; more than 30 active or archived forum discussions and journal club features; a webinar series; an editor-curated weekly updated listing of relevant papers; and several other resources for the pain research community. All content is licensed for reuse under a Creative Commons license; the software is freely available. The framework was reused to develop other sites, notably the Multiple Sclerosis Discovery Forum and StemBook.Discussion: Web-based collaboratories are a crucial integrative tool supporting rapid information transmission and translation in several important research areas. In this article, we discuss the success factors, lessons learned and ongoing challenges in using PRF as a driving force to develop tools for online collaboration in

  2. Pain Research Forum: application of scientific social media frameworks in neuroscience.

    Science.gov (United States)

    Das, Sudeshna; McCaffrey, Patricia G; Talkington, Megan W T; Andrews, Neil A; Corlosquet, Stéphane; Ivinson, Adrian J; Clark, Tim

    2014-01-01

    Social media has the potential to accelerate the pace of biomedical research through online collaboration, discussions, and faster sharing of information. Focused web-based scientific social collaboratories such as the Alzheimer Research Forum have been successful in engaging scientists in open discussions of the latest research and identifying gaps in knowledge. However, until recently, tools to rapidly create such communities and provide high-bandwidth information exchange between collaboratories in related fields did not exist. We have addressed this need by constructing a reusable framework to build online biomedical communities, based on Drupal, an open-source content management system. The framework incorporates elements of Semantic Web technology combined with social media. Here we present, as an exemplar of a web community built on our framework, the Pain Research Forum (PRF) (http://painresearchforum.org). PRF is a community of chronic pain researchers, established with the goal of fostering collaboration and communication among pain researchers. Launched in 2011, PRF has over 1300 registered members with permission to submit content. It currently hosts over 150 topical news articles on research; more than 30 active or archived forum discussions and journal club features; a webinar series; an editor-curated weekly updated listing of relevant papers; and several other resources for the pain research community. All content is licensed for reuse under a Creative Commons license; the software is freely available. The framework was reused to develop other sites, notably the Multiple Sclerosis Discovery Forum (http://msdiscovery.org) and StemBook (http://stembook.org). Web-based collaboratories are a crucial integrative tool supporting rapid information transmission and translation in several important research areas. In this article, we discuss the success factors, lessons learned, and ongoing challenges in using PRF as a driving force to develop tools for

  3. Economic Research Forum for the Arab Countries, Iran and Turkey ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    It is dedicated to providing high quality economic research to contribute to ... to IDRC programming priorities in trade, employment and competitiveness. ... Congratulations to the first cohort of Women in Climate Change Science Fellows!

  4. Proceedings of Nova Scotia's 2006 energy research and development forum

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    The Nova Scotia 2006 energy research and development forum provided a venue for experts from industry, research institutions and government to discuss how research and development will shape the future of energy in the province. The forum was divided into 3 sessions: (1) building knowledge about the marine environment, (2) building knowledge about geoscience, and (3) building knowledge about sustainable energy. A wide ranges of issues related to the Nova Scotia region included whale identification; fisheries mapping; the commercialization of hydrocarbon discoveries; carbon capture and storage and petroleum system analysis and prospect evaluation. Keynote addresses were presented on produced water in Norway; deepwater exploration in Morocco; renewable energy and Canada's role as an energy superpower. The conference featured more than 57 presentations, of which 4 have been catalogued separately for inclusion in this database. refs., tabs., figs.

  5. PCOS Forum: research in polycystic ovary syndrome today and tomorrow.

    Science.gov (United States)

    Pasquali, Renato; Stener-Victorin, Elisabet; Yildiz, Bulent O; Duleba, Antoni J; Hoeger, Kathleen; Mason, Helen; Homburg, Roy; Hickey, Theresa; Franks, Steve; Tapanainen, Juha S; Balen, Adam; Abbott, David H; Diamanti-Kandarakis, Evanthia; Legro, Richard S

    2011-04-01

    To summarize promising areas of investigation into polycystic ovary syndrome (PCOS) and to stimulate further research in this area. Summary of a conference held by international researchers in the field of polycystic ovary syndrome. Potential areas of further research activity include the analysis of predisposing conditions that increase the risk of PCOS, particularly genetic background and environmental factors, such as endocrine disruptors and lifestyle. The concept that androgen excess may contribute to insulin resistance needs to be re-examined from a developmental perspective, since animal studies have supported the hypothesis that early exposure to modest androgen excess is associated with insulin resistance. Defining alterations of steroidogenesis in PCOS should quantify ovarian, adrenal and extraglandular contribution, as well as clearly define blood reference levels by some universal standard. Intraovarian regulation of follicle development and mechanisms of follicle arrest should be further elucidated. Finally, PCOS status is expected to have long-term consequences in women, specifically the development of type 2 diabetes, cardiovascular diseases and hormone dependent cancers. Identifying susceptible individuals through genomic and proteomic approaches would help to individualize therapy and prevention. There are several intriguing areas for future research in PCOS. A potential limitation of our review is that we focused selectively on areas we viewed as the most controversial. © 2011 Blackwell Publishing Ltd.

  6. Schizophrenia.

    Science.gov (United States)

    Kahn, René S; Sommer, Iris E; Murray, Robin M; Meyer-Lindenberg, Andreas; Weinberger, Daniel R; Cannon, Tyrone D; O'Donovan, Michael; Correll, Christoph U; Kane, John M; van Os, Jim; Insel, Thomas R

    2015-11-12

    Schizophrenia is a chronic psychiatric disorder with a heterogeneous genetic and neurobiological background that influences early brain development, and is expressed as a combination of psychotic symptoms - such as hallucinations, delusions and disorganization - and motivational and cognitive dysfunctions. The mean lifetime prevalence of the disorder is just below 1%, but large regional differences in prevalence rates are evident owing to disparities in urbanicity and patterns of immigration. Although gross brain pathology is not a characteristic of schizophrenia, the disorder involves subtle pathological changes in specific neural cell populations and in cell-cell communication. Schizophrenia, as a cognitive and behavioural disorder, is ultimately about how the brain processes information. Indeed, neuroimaging studies have shown that information processing is functionally abnormal in patients with first-episode and chronic schizophrenia. Although pharmacological treatments for schizophrenia can relieve psychotic symptoms, such drugs generally do not lead to substantial improvements in social, cognitive and occupational functioning. Psychosocial interventions such as cognitive-behavioural therapy, cognitive remediation and supported education and employment have added treatment value, but are inconsistently applied. Given that schizophrenia starts many years before a diagnosis is typically made, the identification of individuals at risk and those in the early phases of the disorder, and the exploration of preventive approaches are crucial.

  7. Reliability and Engineering of Thin-Film Photovoltaic Modules. Research forum proceedings

    Science.gov (United States)

    Ross, R. G., Jr. (Editor); Royal, E. L. (Editor)

    1985-01-01

    A Research Forum on Reliability and Engineering of Thin Film Photovoltaic Modules, under sponsorship of the Jet Propulsion Laboratory's Flat Plate Solar Array (FSA) Project and the U.S. Department of Energy, was held in Washington, D.C., on March 20, 1985. Reliability attribute investigations of amorphous silicon cells, submodules, and modules were the subjects addressed by most of the Forum presentations. Included among the reliability research investigations reported were: Arrhenius-modeled accelerated stress tests on a Si cells, electrochemical corrosion, light induced effects and their potential effects on stability and reliability measurement methods, laser scribing considerations, and determination of degradation rates and mechanisms from both laboratory and outdoor exposure tests.

  8. Forum on Emerging Infectious Diseases Highlights Leading-Edge Research | Poster

    Science.gov (United States)

    Scientists and professionals from multiple governmental agencies recently gathered at NCI at Frederick for a forum on newly emerging infectious diseases, threats to public health, and ongoing efforts to study high-risk pathogens. During the one-day event, which was sponsored by the National Interagency Confederation for Biological Research’s Scientific Interaction Subcommittee, nine speakers from four agencies shared their research and their agencies’ endeavors to address current and future biological threats.

  9. Resilience research in schizophrenia: a review of recent developments.

    Science.gov (United States)

    Mizuno, Yuya; Wartelsteiner, Fabienne; Frajo-Apor, Beatrice

    2016-05-01

    The concept of resilience is expected to be relevant in understanding the heterogeneous outcomes associated with schizophrenia. We reviewed recent developments in clinical studies focusing on the biological and psychological aspects of resilience in this population. We aimed to clarify current concepts of resilience in the field, elucidate gaps in the literature, and provide recommendations for future research. A total of 20 articles published between 2014 and 2015 were included. Six studies were neuroimaging studies, while the remaining studies used various psychological assessments. Most studies were cross-sectional except for three studies with naturalistic follow-up, one single-blind randomized controlled trial, and two published protocols of prospective studies. The following patterns of research were evident among the highly heterogeneous literature: studies focusing on protective factors and others emphasizing dynamic processes, studies investigating 'at-risk but resilient' groups (e.g. nonpsychotic siblings of patients with schizophrenia), and studies using psychological scales to measure resilience. The heterogeneity in how reports conceptualize, assess, and interpret resilience likely reflects the multidimensional nature of the concept itself and the lack of a 'gold standard' in assessing resilience in schizophrenia. Further research is needed to make recommendations on how to facilitate resilience in clinical care.

  10. A Resurgence of United Kingdom Nuclear Power Research (2011 EFRC Forum)

    International Nuclear Information System (INIS)

    Grimes, Robin W.

    2011-01-01

    Robin W. Grimes, Professor at Imperial College, London, was the third speaker in the May 26, 2011 EFRC Forum session, 'Global Perspectives on Frontiers in Energy Research.' In his presentation, Professor Grimes discussed recent research endeavors in advanced nuclear energy systems being pursued in the UK. The 2011 EFRC Summit and Forum brought together the EFRC community and science and policy leaders from universities, national laboratories, industry and government to discuss 'Science for our Nation's Energy Future.' In August 2009, the Office of Science established 46 Energy Frontier Research Centers. The EFRCs are collaborative research efforts intended to accelerate high-risk, high-reward fundamental research, the scientific basis for transformative energy technologies of the future. These Centers involve universities, national laboratories, nonprofit organizations, and for-profit firms, singly or in partnerships, selected by scientific peer review. They are funded at $2 to $5 million per year for a total planned DOE commitment of $777 million over the initial five-year award period, pending Congressional appropriations. These integrated, multi-investigator Centers are conducting fundamental research focusing on one or more of several 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The purpose of the EFRCs is to integrate the talents and expertise of leading scientists in a setting designed to accelerate research that transforms the future of energy and the environment.

  11. Online stroke forum as source of data for qualitative research: insights from a comparison with patients' interviews.

    Science.gov (United States)

    Jamison, James; Sutton, Stephen; Mant, Jonathan; De Simoni, Anna

    2018-03-30

    To determine the appropriateness of an online forum compared with face-to-face interviews as a source of data for qualitative research on adherence to secondary prevention medications after stroke. A comparison of attributes of two data sources, interviews and a forum, using realistic evaluation; a comparison of themes around adherence according to the Perceptions and Practicalities Approach (PAPA) framework. Interviews were conducted in UK GP practices in 2013 and 2014; online posts were written by UK stroke survivors and family members taking part in the online forum of the Stroke Association between 2004 and 2011. 42 interview participants: 28 stroke survivors (age range 61-92 years) and 14 caregivers (85% spouses). 84 online forum participants: 49 stroke survivors (age range 32-72 years) and 33 caregivers (60% sons/daughters). 10 attributes were identified within the two data sources and categorised under three domains (context, mechanisms and outcomes). Participants' characteristics of forum users were often missing. Most forum participants had experienced a stroke within the previous 12 months, while interviewees had done so 1-5 years previously.All interview themes could be matched with corresponding themes from the forum. The forum yielded three additional themes: influence of bad press on taking statins, criticisms of clinicians' prescribing practices and caregiver burden in assisting with medications and being advocates for survivors with healthcare professionals. An online forum is an appropriate source of data for qualitative research on patients' and caregivers' issues with adherence to secondary prevention stroke medications and may offer additional insights compared with interviews, which can be attributed to differences in the approach to data collection. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  12. Online stroke forum as source of data for qualitative research: insights from a comparison with patients’ interviews

    Science.gov (United States)

    Jamison, James; Sutton, Stephen; Mant, Jonathan; De Simoni, Anna

    2018-01-01

    Objective To determine the appropriateness of an online forum compared with face-to-face interviews as a source of data for qualitative research on adherence to secondary prevention medications after stroke. Design A comparison of attributes of two data sources, interviews and a forum, using realistic evaluation; a comparison of themes around adherence according to the Perceptions and Practicalities Approach (PAPA) framework. Setting Interviews were conducted in UK GP practices in 2013 and 2014; online posts were written by UK stroke survivors and family members taking part in the online forum of the Stroke Association between 2004 and 2011. Participants 42 interview participants: 28 stroke survivors (age range 61–92 years) and 14 caregivers (85% spouses). 84 online forum participants: 49 stroke survivors (age range 32–72 years) and 33 caregivers (60% sons/daughters). Results 10 attributes were identified within the two data sources and categorised under three domains (context, mechanisms and outcomes). Participants’ characteristics of forum users were often missing. Most forum participants had experienced a stroke within the previous 12 months, while interviewees had done so 1–5 years previously. All interview themes could be matched with corresponding themes from the forum. The forum yielded three additional themes: influence of bad press on taking statins, criticisms of clinicians’ prescribing practices and caregiver burden in assisting with medications and being advocates for survivors with healthcare professionals. Conclusions An online forum is an appropriate source of data for qualitative research on patients’ and caregivers’ issues with adherence to secondary prevention stroke medications and may offer additional insights compared with interviews, which can be attributed to differences in the approach to data collection. PMID:29602848

  13. Taking patient and public involvement online: qualitative evaluation of an online forum for palliative care and rehabilitation research.

    Science.gov (United States)

    Brighton, Lisa Jane; Pask, Sophie; Benalia, Hamid; Bailey, Sylvia; Sumerfield, Marion; Witt, Jana; de Wolf-Linder, Susanne; Etkind, Simon Noah; Murtagh, Fliss E M; Koffman, Jonathan; Evans, Catherine J

    2018-01-01

    Patient and public involvement (PPI) is increasingly recognised as important in research. Most PPI takes place face-to-face, but this can be difficult for people who are unwell or have caring responsibilities. As these challenges are particularly common in palliative care and rehabilitation research, we developed an online forum for PPI: www.csipublicinvolvement.co.uk. In this study, we explored how well the online forum worked, if it is a suitable method for PPI, and how PPI members and researchers reacted to using it. We used an existing theory about online interventions to help choose the 'right' questions to ask participants. We invited PPI members and researchers who had used the online forum to participate in focus groups, and identified the most important themes discussed. Within this study, PPI members have helped with the interview questions, analysis, and write up. Overall, four PPI members and five researchers participated in the focus groups. Participants felt the online forum worked well and had multiple benefits. From the discussions, we identified four key questions to consider when developing online methods for PPI: how does the forum work, how does it engage people, how does it empower people, and what is the impact? Participants suggested the forum could be improved by being more PPI and less researcher focused. We conclude that when developing online methods of PPI, a functioning forum is not enough: it also needs to be engaging and empowering to have an impact. Future work can use these four domains when developing their own online PPI methods. Patient and public involvement (PPI) in research is increasingly recognised as important. Most PPI activities take place face-to-face, yet this can be difficult for people with ill health or caring responsibilities, and may exclude people from hard-to-reach populations (e.g. living in vulnerable social circumstances and/or remote geographical locations). These challenges are particularly pertinent in

  14. The vulnerability to schizophrenia mainstream research paradigms and phenomenological directions.

    Science.gov (United States)

    Stanghellini, Giovanni; Fusar-Poli, Paolo

    2012-01-01

    Early psychopathological attempts to characterize the vulnerability to schizophrenia were based on the phenomenological method. From the beginning, phenomenologically-oriented psychopathologists have searched the basic vulnerability underlying schizophrenic phenomena in two main domains: depersonalization and derealisation/desocialization. Schizophrenic persons undergo a special kind of depersonalisation: the living body becomes a functioning body, a thing-like mechanism in which feelings, perceptions, and actions take place as if they happened in an outer space. They also endure a special kind of derealisation/de-socialization: the interpersonal scene becomes like a theatre stage, pervaded with a sense of unreality, on which the main actor is unaware of the plot, out of touch with the role he is acting and unable to make sense of the objects he encounters and of what the other people are doing. Many years later, the mainstream research paradigms employed to investigate the vulnerability concept in schizophrenic psychosis have included genetic studies, birth cohort studies, psychosis proneness, and clinical high risk. We will review these studies and conclude with an outline of future research directions focusing on three main features of the psychopathology of early schizophrenia: anomalies of the pre-reflexive self and of the social self (intersubjectivity), and existential re-orientation.

  15. Future buildings Forum-2025: Toward a methodology for future buildings research

    Energy Technology Data Exchange (ETDEWEB)

    Briggs, R.S.

    1990-10-01

    The purpose of this paper is to explore methods that could be used in studying buildings of the future. The methodology that the forum will develop will have a number of likely applications, among them: the development of research agendas for new building energy technologies; the development of information and analytical capabilities usable by other IEA annexes to address their technology assessment needs; and the generation of information that can serve as input to global energy models designed to inform energy policy decisions. This paper is divided into two major sections. The first is an overview of existing methods of futures research. Terms and concepts are explained, providing the basis for the second section. The second section proposes a framework and general methodology for studying future buildings. This preliminary, or strawman, methodology is intended to provoke early thinking and discussions on how the research should be approached. 24 refs., 8 figs.

  16. Studies in Teaching: 2016 Research Digest. Action Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, Jun 30, 2016)

    Science.gov (United States)

    McCoy, Leah P., Ed.

    2016-01-01

    This document presents the proceedings of the 21st Annual Research Forum held June 30, 2016, at Wake Forest University in Winston-Salem, North Carolina. Included are the following 11 action research papers: The Use of Mexican Folk Art to Develop Oral and Written Language Ability and Cultural Awareness in the Secondary Spanish Classroom (Antonio…

  17. Studies in Teaching: 2015 Research Digest. Action Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, June 25, 2015)

    Science.gov (United States)

    McCoy, Leah P., Ed.

    2015-01-01

    This document presents the proceedings of the 20th Annual Research Forum held June 25, 2015, at Wake Forest University in Winston-Salem, North Carolina. Included are the following 21 action research papers: (1) History Lives! The Use of Simulations in a High School Social Studies Classroom (Lydia Adkins); (2) Using Francophone Music in the High…

  18. Studies in Teaching: 2017 Research Digest. Action Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, June 29, 2017)

    Science.gov (United States)

    McCoy, Leah P., Ed.

    2017-01-01

    This document presents the proceedings of the 22nd Annual Research Forum held June 29, 2017, at Wake Forest University in Winston-Salem, North Carolina. Included are the following 12 action research papers: (1) Using Captioned Video to Teach Listening Comprehension in a Spanish Classroom (Michelle Allen); (2) Multimodal Instruction: How Film…

  19. Embodied positioning/discourse analysis of a research based leadership development forum

    DEFF Research Database (Denmark)

    Bager, Ann

    2018-01-01

    The present article engages a discourse analysis of identity work as it is accomplished in a research and dialogue based leadership development forum in a university setting. It displays how different interactional setups in a positioning exercise prompt diverse spaces of possibilities that shape...... the identity work in situ. Through a micro-generic positioning analysis of the participants’ small story efforts (M. Bamberg, 2006; M. Bamberg & Georgakopoulou, 2008) combined with an analysis of dialogicality and other-orientation (Bakhtin, 1986; Linell, 2009) it is shown how counter and complicit discourses...... as a natural positive phenomenon with attached emancipating consequences. It aspires to emphasize both the boarder (D) and the local (d) dimensions of discourse, which is increasingly pursued and recommended within the field of interaction, dialogue and discourse studies. (Bager, 2013; Bager et al...

  20. Eating Disorders in Schizophrenia: Implications for Research and Management

    Directory of Open Access Journals (Sweden)

    Youssef Kouidrat

    2014-01-01

    Full Text Available Objective. Despite evidence from case series, the comorbidity of eating disorders (EDs with schizophrenia is poorly understood. This review aimed to assess the epidemiological and clinical characteristics of EDs in schizophrenia patients and to examine whether the management of EDs can be improved. Methods. A qualitative review of the published literature was performed using the following terms: “schizophrenia” in association with “eating disorders,” “anorexia nervosa,” “bulimia nervosa,” “binge eating disorder,” or “night eating syndrome.” Results. According to our literature review, there is a high prevalence of comorbidity between schizophrenia and EDs. EDs may occur together with or independent of psychotic symptoms in these patients. Binge eating disorders and night eating syndromes are frequently found in patients with schizophrenia, with a prevalence of approximately 10%. Anorexia nervosa seems to affect between 1 and 4% of schizophrenia patients. Psychopathological and neurobiological mechanisms, including effects of antipsychotic drugs, should be more extensively explored. Conclusions. The comorbidity of EDs in schizophrenia remains relatively unexplored. The clearest message of this review is the importance of screening for and assessment of comorbid EDs in schizophrenia patients. The management of EDs in schizophrenia requires a multidisciplinary approach to attain maximized health outcomes. For clinical practice, we propose some recommendations regarding patient-centered care.

  1. Social Cognition in Schizophrenia: An NIMH Workshop on Definitions, Assessment, and Research Opportunities

    Science.gov (United States)

    Green, Michael F.; Penn, David L.; Bentall, Richard; Carpenter, William T.; Gaebel, Wolfgang; Gur, Ruben C.; Kring, Ann M.; Park, Sohee; Silverstein, Steven M.; Heinssen, Robert

    2008-01-01

    Social cognition has become a high priority area for the study of schizophrenia. However, despite developments in this area, progress remains limited by inconsistent terminology and differences in the way social cognition is measured. To address these obstacles, a consensus-building meeting on social cognition in schizophrenia was held at the National Institute of Mental Health in March 2006. Agreement was reached on several points, including definitions of terms, the significance of social cognition for schizophrenia research, and suggestions for future research directions. The importance of translational interdisciplinary research teams was emphasized. The current article presents a summary of these discussions. PMID:18184635

  2. The validity of the schizophrenia diagnosis in the Danish Psychiatric Central Research Register is good

    DEFF Research Database (Denmark)

    Uggerby, Peter; Østergaard, Søren Dinesen; Røge, Rasmus

    2013-01-01

    INTRODUCTION: The Danish Psychiatric Central Research Register (DPCRR) has been used extensively for research purposes during the past decades. The aim of this study was to investigate the validity of the International Classification of Diseases (ICD)-10 schizophrenia diagnosis in the DPCRR...... all 300 case records, the validity of the schizophrenia diagnosis was 89.7%. CONCLUSION: According to this assessment of patient case records, the diagnosis of schizophrenia in the DPCRR has a high validity and is well-suited for research. FUNDING: Aalborg Psychiatric Hospital funded the study...

  3. Creating a Knowledge Translation Platform: nine lessons from the Zambia Forum for Health Research

    Directory of Open Access Journals (Sweden)

    Kasonde Joseph M

    2012-10-01

    Full Text Available Abstract The concept of the Knowledge Translation Platform (KTP provides cohesion and leadership for national–level knowledge translation efforts. In this review, we discuss nine key lessons documenting the experience of the Zambia Forum for Health Research, primarily to inform and exchange experience with the growing community of African KTPs. Lessons from ZAMFOHR’s organizational development include the necessity of selecting a multi-stakeholder and -sectoral Board of Directors; performing comprehensive situation analyses to understand not only the prevailing research-and-policy dynamics but a precise operational niche; and selecting a leader that bridges the worlds of research and policy. Programmatic lessons include focusing on building the capacity of both policy-makers and researchers; building a database of local evidence and national-level actors involved in research and policy; and catalyzing work in particular issue areas by identifying leaders from the research community, creating policy-maker demand for research evidence, and fostering the next generation by mentoring both up-and-coming researchers and policy–makers. Ultimately, ZAMFOHR’s experience shows that an African KTP must pay significant attention to its organizational details. A KTP must also invest in the skill base of the wider community and, more importantly, of its own staff. Given the very real deficit of research-support skills in most low-income countries – in synthesis, in communications, in brokering, in training – a KTP must spend significant time and resources in building these types of in-house expertise. And lastly, the role of networking cannot be underestimated. As a fully-networked KTP, ZAMFOHR has benefited from the innovations of other KTPs, from funding opportunities and partnerships, and from invaluable technical support from both African and northern colleagues.

  4. Forum Notes: The 1999 environmental research and technology development forum for the upstream oil and gas industry

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-02-04

    This conference provided an opportunity to exchange information on current research and development projects regarding the environment and the petroleum industry. In addition to summaries of the various sessions, the booklet also includes a list of registrants and poster session participants. The conference was divided into the following three sessions: (1) site remediation, site restoration and groundwater, (2) ecological health, cumulative effects and agriculture, and (3) flaring, odour and greenhouse gas emissions. The session on site remediation heard papers that dealt with feedback on existing projects including soil quality guidelines for crude oil in agricultural soils, hydrophobicity, assessment of phytoremediation as an in-situ technique for cleaning sites polluted by oil, remediation using wetlands, land application of bioremediated soils, and flare pit characterization. The session on ecological health was treated to presentations describing research and development projects including the Eastern Slopes Grizzly Bear Project, the Native Prairie Revegetation Project, and the Caroline Livestock Study. The session on flaring and greenhouse gas emissions described research and development projects on dehydrator benzene emissions, monitoring of odour causing compounds, flare speciation, flare performance, improved liquid separation, alternate technologies, improved measurement of methane fugitive emissions from gas operations, and methane emissions from heavy oil operations.

  5. Forum Notes: The 1999 environmental research and technology development forum for the upstream oil and gas industry

    International Nuclear Information System (INIS)

    1999-01-01

    This conference provided an opportunity to exchange information on current research and development projects regarding the environment and the petroleum industry. In addition to summaries of the various sessions, the booklet also includes a list of registrants and poster session participants. The conference was divided into the following three sessions: (1) site remediation, site restoration and groundwater, (2) ecological health, cumulative effects and agriculture, and (3) flaring, odour and greenhouse gas emissions. The session on site remediation heard papers that dealt with feedback on existing projects including soil quality guidelines for crude oil in agricultural soils, hydrophobicity, assessment of phytoremediation as an in-situ technique for cleaning sites polluted by oil, remediation using wetlands, land application of bioremediated soils, and flare pit characterization. The session on ecological health was treated to presentations describing research and development projects including the Eastern Slopes Grizzly Bear Project, the Native Prairie Revegetation Project, and the Caroline Livestock Study. The session on flaring and greenhouse gas emissions described research and development projects on dehydrator benzene emissions, monitoring of odour causing compounds, flare speciation, flare performance, improved liquid separation, alternate technologies, improved measurement of methane fugitive emissions from gas operations, and methane emissions from heavy oil operations

  6. NEDO Forum 2001. Session on IT (Opening the door to research and development of the future); NEDO Forum 2001. IT session (kenkyu kaihatsu no mirai wo hiraku)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-09-20

    The presentations made at the above-said session on IT (information technology) of the NEDO (New Energy and Industrial Technology Development Organization) forum held in Tokyo on September 20, 2001, are collected in this report. Visiting Professor Emeritus Makoto Kikuchi of Tokai University in his lecture entitled 'Message to young researchers' cited lessons from the history of semiconductor research and development and stressed the importance of management and of the vitality to be produced by tension at the working place. He predicted that in the future the merit that technologies would present would be valued higher than the development of technologies and that software programs would grow in relative importance. Professor Sakurai of Institute of Industrial Science, University of Tokyo, in his lecture entitled 'What people want from research and development in the future' dealt with propensity for application, coordination of different technologies, and the importance of the internationalization of persons of talent. Chief Engineer Murakami of Sumitomo Electric Industries Ltd. spoke in his lecture, entitled 'Research and development strategy in business corporations,' about corporate consciousness of research and development in Japan, development and use of new scoring methods, and one-sigma management. (NEDO)

  7. Publishing Your Music Education Research: A Seminar for Future Authors--A Summary of the 2009 Ohio Music Education Association Research Forum Presented By Dr. Wendy Sims

    Science.gov (United States)

    Schatt, Matthew D.

    2009-01-01

    The Ohio Music Education Association (OMEA) Research Committee annually hosts a Graduate Research Forum in conjunction with the OMEA's Professional Development Conference. In 2009, the guest speaker was Dr. Wendy Sims, Director of Music Education at the University of Missouri--Columbia and Editor of the Journal of Research in Music Education. An…

  8. Schizophrenia

    Science.gov (United States)

    ... Library Public Policy Research Find Support Free Support 24/7 Text NAMI to 741741 Find Help Living with ... 6264 Press & Media In A Crisis? Stay Connected facebook twitter Instagram tumblr youtube Discussion Groups Terms of ...

  9. The EC Maritime Industries Forum 1992: Marine resources and research and development

    International Nuclear Information System (INIS)

    Jenisch, U.K.

    1993-01-01

    The Maritime Industries Forum (MIF) of the European Community has prepared a comprehensive report covering all the EC maritime industries. The report, published on October 29, 1992, addresses maritime activities such as shipbuilding, shipping, fishing, energy, marine resources and environmental protection. Focal points are research and development measures and strategies. A major objective is to strengthen the competitiveness of the maritime industries via a global and horizontal approach. This paper briefly analyses the M.I.F. Report and concentrates on the EC interests in the field of marine resources such as oil and gas, potable water, aquaculture and fishing, minerals, OTEC/DOWA as well as the environmentally sound technology that is required to allow for a future oriented and sustainable exploitation. Export opportunities for such new technologies and cooperation with third states are an important objective. The proposals of the M.I.F. Report are of a positive, future-oriented nature, appropriate to replace many of the hitherto defensive policies in the maritime area. The industries recognize the responsibility for the revitalization of their industrial sectors. The method of this broad sectoral approach for a new industrial policy in Europe is innovative and a model in itself. With the installation of three specialized new industrial panels in January 1993 the work continues

  10. Petroleum environmental research forum field study on biofilters for control of volatile hydrocarbons

    International Nuclear Information System (INIS)

    Leson, G.; Smith, B.J.

    1997-01-01

    A field study on the treatment of volatile petroleum hydrocarbons (PHC) by biofiltration was conducted by the Petroleum Environmental Research Forum (PERF) between 1992 and 1994. Its objective was to assess the technical, regulatory, and economic feasibility of biofiltration for off-gases from petroleum processing and soil remediation equipment. It involved three small-scale biofilters provided by US vendors, treating off-gas from two soil vapor extraction sites and a source of refinery wastewater. Comprehensive monitoring of biofilter operating parameters and performance was conducted. Typically more than 95% of aromatic compounds such as benzene, and odorous reduced sulfur compounds can be removed at residence times of one minute or less, while removal of more than 70% of light aliphatics will require residence times of several minutes, and will thus require correspondingly large filter volumes and higher capital expenditure. The high percentage removal of aromatic hazardous air pollutants (HAP) and odors can generally be accomplished at comparatively short residence times while the need for high-percentage removal, particular of light aliphatics ( 5 ) will generally render biofiltration noncompetitive. Finally, a preliminary economic comparison of biofilters and established control technologies suggested that biofiltration may, for a representative design case involving off-gas from a refinery wastewater treatment operation, offer considerable savings in total cost of air pollution control for petroleum hydrocarbon streams if regulations require the control of aromatic HAP or odors

  11. The Schizophrenia Patient Outcomes Research Team (PORT): updated treatment recommendations 2009.

    Science.gov (United States)

    Kreyenbuhl, Julie; Buchanan, Robert W; Dickerson, Faith B; Dixon, Lisa B

    2010-01-01

    The Schizophrenia Patient Outcomes Research Team (PORT) project has played a significant role in the development and dissemination of evidence-based practices for schizophrenia. In contrast to other clinical guidelines, the Schizophrenia PORT Treatment Recommendations, initially published in 1998 and first revised in 2003, are based primarily on empirical data. Over the last 5 years, research on psychopharmacologic and psychosocial treatments for schizophrenia has continued to evolve, warranting an update of the PORT recommendations. In consultation with expert advisors, 2 Evidence Review Groups (ERGs) identified 41 treatment areas for review and conducted electronic literature searches to identify all clinical studies published since the last PORT literature review. The ERGs also reviewed studies preceding 2002 in areas not covered by previous PORT reviews, including smoking cessation, substance abuse, and weight loss. The ERGs reviewed over 600 studies and synthesized the research evidence, producing recommendations for those treatments for which the evidence was sufficiently strong to merit recommendation status. For those treatments lacking empirical support, the ERGs produced parallel summary statements. An Expert Panel consisting of 39 schizophrenia researchers, clinicians, and consumers attended a conference in November 2008 in which consensus was reached on the state of the evidence for each of the treatment areas reviewed. The methods and outcomes of the update process are presented here and resulted in recommendations for 16 psychopharmacologic and 8 psychosocial treatments for schizophrenia. Another 13 psychopharmacologic and 4 psychosocial treatments had insufficient evidence to support a recommendation, representing significant unmet needs in important treatment domains.

  12. Eating Disorders in Schizophrenia: Implications for Research and Management

    OpenAIRE

    Kouidrat, Youssef; Amad, Ali; Lalau, Jean-Daniel; Loas, Gwenole

    2014-01-01

    Objective. Despite evidence from case series, the comorbidity of eating disorders (EDs) with schizophrenia is poorly understood. This review aimed to assess the epidemiological and clinical characteristics of EDs in schizophrenia patients and to examine whether the management of EDs can be improved. Methods. A qualitative review of the published literature was performed using the following terms: “schizophrenia” in association with “eating disorders,” “anorexia nervosa,” “bulimia nervosa,” “b...

  13. EDM forum supplement overview.

    Science.gov (United States)

    Calonge, Ned

    2012-07-01

    The Agency for Health Research and Quality funded the Electronic Data Methods Forum (EDM Forum) to share the experiences and learnings from 11 research teams funded through three different grant programs, each of which involve the use of electronic clinical data in Comparative Effectiveness Research and Patient-Centered Outcomes Research. This overview is meant to describe the context in which the EDM forum was created and to introduce the set of papers in this supplement to Medical Care that describe the challenges and approaches to the use of electronic clinical data in the three key areas of analytic methods, clinical informatics and data governance. The participants in the EDM Forum are providing innovative approaches to generate information that can support the building of a "learning health care system." The compilation of papers presented in this supplement should serve as a resource to others working to develop the infrastructure for collecting, validating and using electronic data for research.

  14. Forum: Interpersonal Communication in Instructional Settings: Interpersonal Communication Research in Instructional Contexts: A Dyadic Approach

    Science.gov (United States)

    Goodboy, Alan K.; Kashy, Deborah A.

    2017-01-01

    Do we study too much interpersonal communication and not enough of other topics in the instructional communication literature? This forum provides a mixed bag of both affirmative and negative responses to this question. On one hand, answering "yes" is quite defensible because there are many recent studies examining interpersonal…

  15. Forum on Emerging Infectious Diseases Highlights Leading-Edge Research | Poster

    Science.gov (United States)

    Scientists and professionals from multiple governmental agencies recently gathered at NCI at Frederick for a forum on newly emerging infectious diseases, threats to public health, and ongoing efforts to study high-risk pathogens. During the one-day event, which was sponsored by the National Interagency Confederation for Biological Research’s Scientific Interaction

  16. Student Interactions in Online Discussion Forum: Empirical Research from "Media Richness Theory" Perspective

    Science.gov (United States)

    Balaji, M. S.; Chakrabarti, Diganta

    2010-01-01

    The present study contributes to the understanding of the effectiveness of online discussion forum in student learning. A conceptual model based on "theory of online learning" and "media richness theory" was proposed and empirically tested. We extend the current understanding of media richness theory to suggest that use of…

  17. Forum: Learning Outcomes in Communication. Responses. On the Importance of Communication Research

    Science.gov (United States)

    Vangelisti, Anita L.

    2016-01-01

    Anita Vangelisti writes in this response that although the recommendations set forward in this "Forum" are well thought out and important additions to the discussion, teacher-scholars in the field of communication can, and should, do more. She agrees that there is a need to identify and describe learning outcomes in communication, and…

  18. Papers of the PTAC Air Issues Research Forum : research priorities, discussion, and networking reception

    International Nuclear Information System (INIS)

    2003-01-01

    This meeting was open to representatives from the petroleum industry, regulators, researchers, and service and supply providers. The presenters described technologies that can effectively improve the environmental performance of energy industries. The conference provided an opportunity to learn where research dollars are being spent to improve economic performance while minimizing environmental impacts. It also revealed information on emission reduction regulations and targets and provided an opportunity to learn about the most recent advances in modeling, simulation and expert systems. The meeting featured 10 presentations, of which 4 have been indexed separately for inclusion in this database. tabs., figs

  19. Ethical practice in internet research involving vulnerable people: lessons from a self-harm discussion forum study (SharpTalk).

    Science.gov (United States)

    Sharkey, Siobhan; Jones, Ray; Smithson, Janet; Hewis, Elaine; Emmens, Tobit; Ford, Tamsin; Owens, Christabel

    2011-12-01

    The internet is widely used for health information and support, often by vulnerable people. Internet-based research raises both familiar and new ethical problems for researchers and ethics committees. While guidelines for internet-based research are available, it is unclear to what extent ethics committees use these. Experience of gaining research ethics approval for a UK study (SharpTalk), involving internet-based discussion groups with young people who self-harm and health professionals is described. During ethical review, unsurprisingly, concerns were raised about the vulnerability of potential participants. These were dominated by the issue of anonymity, which also affected participant safety and consent. These ethical problems are discussed, and our solutions, which included: participant usernames specific to the study, a closed website, private messaging facilities, a direct contact email to researchers, information about forum rules displayed on the website, a 'report' button for participants, links to online support, and a discussion room for forum moderators. This experience with SharpTalk suggests that an approach to ethics, which recognises the relational aspects of research with vulnerable people, is particularly useful for internet-based health research. The solutions presented here can act as guidance for researchers developing proposals and for ethics committees reviewing them.

  20. Bridging the Measurement Gap Between Research and Clinical Care in Schizophrenia

    DEFF Research Database (Denmark)

    Østergaard, Søren D; Opler, Mark G A; Correll, Christoph U

    2017-01-01

    studies suggest that the much briefer PANSS-6 is a psychometrically valid measure of core positive and negative symptoms of schizophrenia and that the scale is sensitive to symptom improvement following pharmacological treatment. SNAPSI is a brief interview that yields the information needed to rate PANSS......There is currently a "measurement gap" between research and clinical care in schizophrenia. The main reason behind this gap is that the most widely used rating scale in schizophrenia research, the 30-item Positive and Negative Syndrome Scale (PANSS), takes so long to administer that it is rarely......-item PANSS in clinical practice; 2) how the brief, six-item version of the Positive and Negative Syndrome Scale (PANSS-6) was derived empirically from the full 30-item PANSS and what the initial results obtained with PANSS-6 entail; and 3) how PANSS-6 ratings, guided by the newly developed, 15...

  1. Internet Forums for Suicide Bereavement.

    Science.gov (United States)

    Bailey, Eleanor; Krysinska, Karolina; O'Dea, Bridianne; Robinson, Jo

    2017-11-01

    Bereavement by suicide is associated with a number of consequences including poor mental health outcomes and increased suicide risk. Despite this, the bereaved by suicide may be reluctant to seek help from friends, family, and professionals. Internet forums and social networking sites are a popular avenue of support for the bereaved, but to date there is a lack of research into their use and efficacy. To survey users of suicide bereavement Internet forums and Facebook groups regarding their help-seeking behaviors, use of forums, and perceived benefits and limitations of such use. This study employed a cross-sectional design in which users of suicide bereavement Internet forums and Facebook groups completed an anonymous online survey. Participants were 222 users of suicide bereavement Internet forums. Most participants (93.2%) had sought face-to-face help from sources other than Internet forums, but were more likely to seek help in the near future from informal rather than formal sources. Forums were perceived as highly beneficial and there were few limitations. The generalizability of these results to other internet forums may be limited. Additionally, we were not able to examine differences between forums in terms of quality or user-reported efficacy. Finally, the data reflects the subjective views of forum users, which may differ from the views of moderators or experts. Internet forums, including Facebook groups, appear to be a useful adjunct to face-to-face help-seeking for supporting those who have been bereaved by suicide.

  2. Carbon sequestration leadership forum

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    The Carbon Sequestration Leadership Forum (CSLF) is an international climate change initiative that will focus on development of carbon capture and storage technologies as a means of accomplishing long-term stabilisation of greenhouse gas levels in the atmosphere. This initiative is designed to improve these technologies through coordinated research and development with international partners and private industry. Three types of cooperation are currently envisioned within the framework of the Forum: data gathering, information exchange, and joint projects. Data gathered from participating countries will be aggregated, summarised, and distributed to all of the Forum's participants. Joint projects will be identified by member nations with the Forum serving as a mechanism for bringing together government and private sector representatives from member countries. The article also reports the inaugural meeting which was held 23-25 June 2003 in Washington.

  3. Improved tools and strategies for the prevention and control of arboviral diseases: A research-to-policy forum.

    Directory of Open Access Journals (Sweden)

    Piero Olliaro

    2018-02-01

    Full Text Available Research has been conducted on interventions to control dengue transmission and respond to outbreaks. A summary of the available evidence will help inform disease control policy decisions and research directions, both for dengue and, more broadly, for all Aedes-borne arboviral diseases.A research-to-policy forum was convened by TDR, the Special Programme for Research and Training in Tropical Diseases, with researchers and representatives from ministries of health, in order to review research findings and discuss their implications for policy and research.The participants reviewed findings of research supported by TDR and others. Surveillance and early outbreak warning. Systematic reviews and country studies identify the critical characteristics that an alert system should have to document trends reliably and trigger timely responses (i.e., early enough to prevent the epidemic spread of the virus to dengue outbreaks. A range of variables that, according to the literature, either indicate risk of forthcoming dengue transmission or predict dengue outbreaks were tested and some of them could be successfully applied in an Early Warning and Response System (EWARS. Entomological surveillance and vector management. A summary of the published literature shows that controlling Aedes vectors requires complex interventions and points to the need for more rigorous, standardised study designs, with disease reduction as the primary outcome to be measured. House screening and targeted vector interventions are promising vector management approaches. Sampling vector populations, both for surveillance purposes and evaluation of control activities, is usually conducted in an unsystematic way, limiting the potentials of entomological surveillance for outbreak prediction. Combining outbreak alert and improved approaches of vector management will help to overcome the present uncertainties about major risk groups or areas where outbreak response should be initiated and

  4. Schizophrenia research participants' responses to protocol safeguards: recruitment, consent, and debriefing.

    Science.gov (United States)

    Roberts, Laura Weiss; Warner, Teddy D; Anderson, Charles T; Smithpeter, Megan V; Rogers, Melinda K

    2004-04-01

    To examine the perspectives and preferences regarding ethically important aspects of recruitment, consent, and debriefing of people with schizophrenia who volunteered for research protocols. A structured interview to assess research-related views of people with schizophrenia was developed and piloted. Data collection occurred at three sites. For this analysis, we examined the subset of responses from schizophrenia patients currently enrolled in a protocol. Data from 28 schizophrenia research volunteers were analyzed. Of these, 22 were men and 11 were voluntary inpatients. Most (n=23) recalled speaking with someone before enrolling in the protocol, and most (n=26) reported trusting the person who told them about it. Participants reported a moderate understanding of their protocols. All but one person (n=27) remembered signing a consent form. Twenty-one volunteers indicated that consent forms are meant to help both the patient and the researcher. Most (n=23) reported making the enrollment decision alone, with 22 making this decision prior to reviewing the consent form. The decision was described as relatively easy. Respondents felt some pressure to enroll, with women experiencing more pressure. Debriefing practices were strongly endorsed by participants. All 28 of the volunteers wished to be informed if a health problem (i.e., "something wrong") was discovered during the protocol. The persons living with schizophrenia who were interviewed for this project expressed interesting perspectives and preferences regarding ethically important aspects of recruitment, consent, and debriefing in clinical research that may help guide efforts to make research processes more attuned to participants and merit further inquiry.

  5. Role of Faculty Development Forums in Virtual Teaching Environment: A Case Study of Marketing Research & Case Group

    Directory of Open Access Journals (Sweden)

    Rizwan Saleem Sandhu

    2016-12-01

    Full Text Available The online learning has broadened the teaching spectrum from Face-to-Face to virtual environment, and this move has brought traditional teacher-centered instruction to learner-centered instruction. This paradigm shift appears to place demands on faculty to modify faculty’s instruction roles that are different from those encountered in Face-to-Face teaching. This study explores the role of faculty development forum in improving the virtual teaching skills of academic staff members in an online university. The study has used single holistic case study approach, and the data from nine respondents have been collected through an interview schedule divided into four sections of 1 Basic Information, 2 Presentation Skills, 3 Subject Knowledge and 4 Research Orientation as per the objectives of the study. It can be theorized from the findings of the study that in virtual environments where faculty members lack the learning opportunities and exposure available in the conventional environments such forums prove to be very effective in capacity building of the faculty.

  6. Opportunities and challenges for comparative effectiveness research (CER) with Electronic Clinical Data: a perspective from the EDM forum.

    Science.gov (United States)

    Holve, Erin; Segal, Courtney; Hamilton Lopez, Marianne

    2012-07-01

    The Electronic Data Methods (EDM) Forum brings together perspectives from the Prospective Outcome Systems using Patient-specific Electronic data to Compare Tests and therapies (PROSPECT) studies, the Scalable Distributed Research Networks, and the Enhanced Registries projects. This paper discusses challenges faced by the research teams as part of their efforts to develop electronic clinical data (ECD) infrastructure to support comparative effectiveness research (CER). The findings reflect a set of opportunities for transdisciplinary learning, and will ideally enhance the transparency and generalizability of CER using ECD. Findings are based on 6 exploratory site visits conducted under naturalistic inquiry in the spring of 2011. Themes, challenges, and innovations were identified in the visit summaries through coding, keyword searches, and review for complex concepts. : The identified overarching challenges and emerging opportunities include: the substantial level of effort to establish and sustain data sharing partnerships; the importance of understanding the strengths and limitations of clinical informatics tools, platforms, and models that have emerged to enable research with ECD; the need for rigorous methods to assess data validity, quality, and context for multisite studies; and, emerging opportunities to achieve meaningful patient and consumer engagement and work collaboratively with multidisciplinary teams. The new infrastructure must evolve to serve a diverse set of potential users and must scale to address a range of CER or patient-centered outcomes research (PCOR) questions. To achieve this aim-to improve the quality, transparency, and reproducibility of CER and PCOR-a high level of collaboration and support is necessary to foster partnership and best practices as part of the EDM Forum.

  7. SAMJ FORUM

    African Journals Online (AJOL)

    2006-09-01

    Sep 1, 2006 ... SAMJ FORUM. 862. Undernutrition, brain growth and intellectual development ... They were matched for age and sex with a control group of 11 ... of the average weight for Cape Coloured children of this age.' Thus was the ...

  8. Forum Commentary

    Science.gov (United States)

    Kanno, Yasuko

    2014-01-01

    Social class has been underresearched in the field of applied linguistics. The central goal of this forum was to stimulate more conversation about social class as it impacts language learning and teaching. In this article, I comment on 3 salient themes that have emerged in the 5 articles: (1) agency and structure in language learning and teaching,…

  9. Influence of ethical safeguards on research participation: comparison of perspectives of people with schizophrenia and psychiatrists.

    Science.gov (United States)

    Roberts, Laura W; Hammond, Katherine A Green; Warner, Teddy D; Lewis, Rae

    2004-12-01

    Several safeguards have been developed to protect research volunteers, but little is known about how the people involved in this research-the stakeholders-view these efforts to assure participant rights and well-being. The authors' goal was to examine these perspectives. As part of a larger study, 60 people with schizophrenia and 69 psychiatrists rated the protectiveness and influence on patients' willingness to participate in research of five safeguards: informed consent, alternative decision makers, institutional review boards, data safety monitoring boards, and confidentiality measures. All safeguards were perceived by both the participants with schizophrenia and by the psychiatrists as protective: on a scale of 1-5 on which 1=not protective at all and 5=very much protects, the mean scores ranged from 3.54 to 4.07. Four of the five safeguards were perceived by both the people with schizophrenia and by the psychiatrists as positively influencing patients' participation decisions. On a scale of 1-5 on which 1=much less willing and 5=much more willing to participate, the mean scores for these four safeguards ranged from 3.86 to 4.30. The mean score for the safeguard of an alternative decision maker, however, was 3.09. The ratings of protectiveness made by both the people with schizophrenia and the psychiatrists were correlated with their ratings of patients' willingness to participate in studies. Ethical commitment to research volunteers is expressed in safeguards. These efforts appear to be viewed positively by key stakeholders and may influence research participation decision making.

  10. EUROSAFE forum 2016

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-07-01

    The proceedings of the Eurosafe forum 2016 includes contributions to the following issues: Seminar 1: nuclear installation safety - assessment; Seminar 2: Nuclear installation safety - research; Seminar 3: Waste management and decommissioning - dismantling; Seminar 4: radiation protection, environment and emergency preparedness; Seminar 5: security of nuclear installations and materials.

  11. Visions and Options: A Report on Five Forums Introducing the Research Consortium on Building Vocational Education and Training Provider Capability. Occasional Paper

    Science.gov (United States)

    Clayton, Berwyn; Robinson, Pauline

    2008-01-01

    This publication outlines the outcomes of forums held in 2005 to introduce the consortium research program which has investigated ways of building vocational education and training (VET) provider capability. It found a range of issues were of concern to participants as they considered how registered training organisations might position themselves…

  12. [Basic symptoms in schizophrenia, their clinical study and relevance in research].

    Science.gov (United States)

    Miret, Salvador; Fatjó-Vilas, Mar; Peralta, Víctor; Fañanás, Lourdes

    2016-01-01

    Basic symptoms consist of subtle sub-clinical disturbances subjectively experienced by schizophrenia patients. These are mainly related to drive, affect, thinking and language, perception, memory, motor action, central vegetative functions, control of cognitive processes, and stress tolerance. Initially described by Huber, from a phenomenological approach, basic symptoms are part of the earliest features of schizophrenia, and they can evolve along the course of the disorder. Their assessment during the prodromal phase of the disease (together with ultra-high risk criteria) is one of the 2 main approaches that allow the definition of states of clinical risk for the development of psychosis. The present review provides an updated view of the concept of basic symptoms, highlighting its potential value in establishing neurobiological correlates of interest in aetiopathogenic research. Copyright © 2015 SEP y SEPB. Published by Elsevier España. All rights reserved.

  13. When Patient Engagement and Research Ethics Collide: Lessons from a Dementia Forum.

    Science.gov (United States)

    Robillard, Julie M; Feng, Tanya L

    2017-01-01

    The importance of patient engagement in research has been gaining recognition since the turn of the 21st century. However, little is known about the perspectives of people with dementia on the process of discovery. To fill this gap and to inform priorities in patient engagement in the context of dementia research, the Clinic for Alzheimer Disease and Related Disorders at the University of British Columbia hosted an interactive session for members of the patient community and of the general public to share their views on various ethical aspects of the research process. Results from the session indicate that several current research ethics policies and norms in dementia research are not in line with participants' preferences. Here we discuss the importance of bridging the gap between researchers and patients and call for reforms in current standards of dementia research.

  14. Validation study of the early onset schizophrenia diagnosis in the Danish Psychiatric Central Research Register

    DEFF Research Database (Denmark)

    Vernal, Ditte Lammers; Stenstrøm, Anne Dorte; Staal, Nina

    2018-01-01

    on classification. Compared to diagnoses made in outpatient settings, EOS diagnoses during hospitalizations were more likely to be valid and had fewer registration errors. Diagnosed in inpatient settings, EOS diagnoses are reliable and valid for register-based research. Schizophrenia diagnosed in children...... and adolescents in outpatient settings were found to have a high number of false-positives, both due to registration errors and diagnostic practice. Utilizing this knowledge, it is possible to reduce the number of false-positives in register-based research of EOS....

  15. Discussion forum for researchers in nuclear geology: programme, abstracts and newsletter, Pelindaba, Republic of South Africa

    International Nuclear Information System (INIS)

    Brynard, H.J.

    1985-01-01

    The Atomic Energy Corporation of SA Ltd sponsors research in nuclear geology at several South African universities with a view to delineating target areas for uranium prospecting by mining companies. This report covers research done on uranium and thorium mineralization, geohydrology, age estimation, nuclear techniques and isotopic studies. The results of the researches reported is necessarily not complete and the abstracts in this volume should therefore not be regarded as conclusive

  16. Policy Analysis: The New Reality for Institutional Research. AIR Forum 1982 Paper.

    Science.gov (United States)

    Parker, John D.; Fenske, Robert H.

    The problems and opportunities for institutional research in academe as it becomes increasingly policy analytic in activity and orientation are explored. It is suggested that for the 1980s the most viable and dynamic role for institutional research will be in providing leaders in higher education institutions with policy-relevant knowledge in…

  17. Mixing Methods in Instructional Research. Forum: The Future of Instructional Communication

    Science.gov (United States)

    Meluch, Andrea L.

    2017-01-01

    "Communication Education's" commitment to publishing rigorous instructional communication research with a diversity of methods is clear in its publication of quantitative, qualitative, and critical articles (Witt, 2012). Here, Andrea Meluch argues that the trends in the most recent research published within this journal indicate a lack…

  18. The Impact of Personality Factors and Preceding User Comments on the Processing of Research Findings on Deep Brain Stimulation: A Randomized Controlled Experiment in a Simulated Online Forum

    OpenAIRE

    Feinkohl, Insa; Flemming, Danny; Cress, Ulrike; Kimmerle, Joachim

    2016-01-01

    Background Laypeople frequently discuss medical research findings on Web-based platforms, but little is known about whether they grasp the tentativeness that is inherent in these findings. Potential influential factors involved in understanding medical tentativeness have hardly been assessed to date. Objective The research presented here aimed to examine the effects of personality factors and of other users? previous contributions in a Web-based forum on laypeople?s understanding of the tenta...

  19. The Impact of Personality Factors and Preceding User Comments on the Processing of Research Findings on Deep Brain Stimulation: A Randomized Controlled Experiment in a Simulated Online Forum.

    Science.gov (United States)

    Feinkohl, Insa; Flemming, Danny; Cress, Ulrike; Kimmerle, Joachim

    2016-03-03

    Laypeople frequently discuss medical research findings on Web-based platforms, but little is known about whether they grasp the tentativeness that is inherent in these findings. Potential influential factors involved in understanding medical tentativeness have hardly been assessed to date. The research presented here aimed to examine the effects of personality factors and of other users' previous contributions in a Web-based forum on laypeople's understanding of the tentativeness of medical research findings, using the example of research on deep brain stimulation. We presented 70 university students with an online news article that reported findings on applying deep brain stimulation as a novel therapeutic method for depression, which participants were unfamiliar with. In a randomized controlled experiment, we manipulated the forum such that the article was either accompanied by user comments that addressed the issue of tentativeness, by comments that did not address this issue, or the article was accompanied by no comments at all. Participants were instructed to write their own individual user comments. Their scientific literacy, epistemological beliefs, and academic self-efficacy were measured. The outcomes measured were perceived tentativeness and tentativeness addressed in the participants' own comments. More sophisticated epistemological beliefs enhanced the perception of tentativeness (standardized β=.26, P=.034). Greater scientific literacy (stand. β=.25, P=.025) and greater academic self-efficacy (stand. β=.31, P=.007) were both predictors of a more extensive discussion of tentativeness in participants' comments. When forum posts presented in the experiment addressed the issue of tentativeness, participants' subsequent behavior tended to be consistent with what they had read in the forum, F2,63=3.66; P=.049, ηp(2)=.092. Students' understanding of the tentativeness of research findings on deep brain stimulation in an online forum is influenced by a

  20. A Virtual Reality Task Based on Animal Research - Spatial Learning and Memory in Patients after the First Episode of Schizophrenia

    Directory of Open Access Journals (Sweden)

    Iveta eFajnerova

    2014-05-01

    Full Text Available Objective: Cognitive deficit is considered to be a characteristic feature of schizophrenia disorder. A similar cognitive dysfunction was demonstrated in animal models of schizophrenia. However, the poor comparability of methods used to assess cognition in animals and humans could be responsible for low predictive validity of current animal models. In order to assess spatial abilities in schizophrenia and compare our results with the data obtained in animal models we designed a virtual analogue of the Morris water maze (MWM, the virtual Four Goals Navigation (vFGN task.Method: Twenty-nine patients after the first psychotic episode with schizophrenia symptoms and a matched group of healthy volunteers performed the vFGN task. They were required to find and remember four hidden goal positions in an enclosed virtual arena. The task consisted of two parts. The Reference memory (RM session with a stable goal position was designed to test spatial learning. The Delayed-matching-to-place (DMP session presented a modified working memory protocol designed to test the ability to remember a sequence of three hidden goal positions.Results: Data obtained in the RM session show impaired spatial learning in schizophrenia patients compared to healthy controls in pointing and navigation accuracy. The DMP session showed impaired spatial memory in schizophrenia during the recall of spatial sequence and similar deficit in spatial bias in probe trials. The pointing accuracy and the quadrant preference showed higher sensitivity toward the cognitive deficit than the navigation accuracy. Direct navigation to the goal was affected by sex and age of the tested subjects. Age affected spatial performance only in healthy controls. Conclusions: Despite some limitations of the study, our results correspond well to previous studies in animal models of schizophrenia and support the decline of spatial cognition in schizophrenia, indicating the usefulness of the vFGN task in

  1. Towards an "International Forum for Teacher Educator Development": An Agenda for Research and Action

    Science.gov (United States)

    Kelchtermans, Geert; Smith, Kari; Vanderlinde, Ruben

    2018-01-01

    The outcomes of an international collaborative project are presented, involving experienced teacher educators and researchers from eight different countries, who engaged in a series of structured discussions on the professional development of teacher educators. We start with an overview of the needs in practice and policy, as well as the research…

  2. Changes in Institutional Research in Germany. AIR 1991 Annual Forum Paper.

    Science.gov (United States)

    Schultz-Gerstein, Hans-G.

    This paper recounts the legal, political, and educational changes in former East Germany as the nation has become reunified, and considers the implications of reunification for institutional research at East German universities. After a brief sketch of legal, geographic, and demographic highlights, the decrepit conditions of East German university…

  3. Delineating Research Forums for Business and Management Education Scholars: The Business and Management Education Influence Index

    Science.gov (United States)

    Arbaugh, J. B.; Bielinska-Kwapisz, Agnieszka

    2016-01-01

    The authors used bibliometric analysis to create indices for both the percentage of articles a journal publishes on business and management education (BME) research and the relative scholarly impact an article is likely to have after being published in that journal. They envision that the dissemination of these indices will be helpful for scholars…

  4. Is Twitter a forum for disseminating research to health policy makers?

    Science.gov (United States)

    Kapp, Julie M; Hensel, Brian; Schnoring, Kyle T

    2015-12-01

    Findings from scientific research largely remain inside the scientific community. Research scientists are being encouraged to use social media, and especially Twitter, for dissemination of evidence. The potential for Twitter to narrow the gap on evidence translated into policy presents new opportunities. We explored the innovative question of the feasibility of Twitter as a tool for the scientific community to disseminate to and engage with health policy makers for research impact. We created a list of federal "health policy makers." In December 2014, we identified members using several data sources, then collected and summarized their Twitter usage data. Nearly all health policy makers had Twitter accounts. Their communication volume varied broadly. Policy makers are more likely to push information via Twitter than engage with constituents, although usage varied broadly. Twitter has the potential to aid the scientific community in dissemination of health-related research to health policy makers, after understanding how to effectively (and selectively) use Twitter. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. Forum: Communication Activism Pedagogy. Communication Activism Pedagogy and Research: Communication Education Scholarship to Promote Social Justice

    Science.gov (United States)

    Frey, Lawrence R.; Palmer, David L.

    2017-01-01

    The recent formation of the National Communication Association's Activism and Social Justice Division puts a spotlight on the extent to which instructional communication and instructional communication research have advanced--or even should advance--the goals of social justice. To examine this issue, two of the leading scholars on this topic,…

  6. From Local to EXtreme Environments (FLEXE) Student-Scientist Online Forums: hypothesis-based research examining ways to involve scientists in effective science education

    Science.gov (United States)

    Goehring, L.; Carlsen, W.; Fisher, C. R.; Kerlin, S.; Trautmann, N.; Petersen, W.

    2011-12-01

    Science education reform since the mid-1990's has called for a "new way of teaching and learning about science that reflects how science itself is done, emphasizing inquiry as a way of achieving knowledge and understanding about the world" (NRC, 1996). Scientists and engineers, experts in inquiry thinking, have been called to help model these practices for students and demonstrate scientific habits of mind. The question, however, is "how best to involve these experts?" given the very real challenges of limited availability of scientists, varying experience with effective pedagogy, widespread geographic distribution of schools, and the sheer number of students involved. Technology offers partial solutions to enable Student-Scientist Interactions (SSI). The FLEXE Project has developed online FLEXE Forums to support efficient, effective SSIs, making use of web-based and database technology to facilitate communication between students and scientists. More importantly, the FLEXE project has approached this question of "how best to do this?" scientifically, combining program evaluation with hypothesis-based research explicitly testing the effects of such SSIs on student learning and attitudes towards science. FLEXE Forums are designed to showcase scientific practices and habits of mind through facilitated interaction between students and scientists. Through these Forums, students "meet" working scientists and learn about their research and the environments in which they work. Scientists provide students with intriguing "real-life" datasets and challenge students to analyze and interpret the data through guiding questions. Students submit their analyses to the Forum, and scientists provide feedback and connect the instructional activity with real-life practice, showcasing their activities in the field. In the FLEXE project, Forums are embedded within inquiry-based instructional units focused on essential learning concepts, and feature the deep-sea environment in contrast

  7. Dreaming and Schizophrenia.

    Science.gov (United States)

    Stickney, Jeffrey L.

    Parallels between dream states and schizophrenia suggest that the study of dreams may offer some information about schizophrenia. A major theoretical assumption of the research on dreaming and schizophrenia is that, in schizophrenics, the dream state intrudes on the awake state creating a dreamlike symptomatology. This theory, called the REM…

  8. Research Forum on Changes in Sensory Perception in Middle-Aged Adults: A Summary of a Special Session at Hearing Across the Lifespan (HEAL) 2014.

    Science.gov (United States)

    Humes, Larry E

    2015-06-01

    The purpose of this article is to introduce the special research forum on sensory-processing changes in middle-aged adults. This is a brief written introduction to the special session, which included five presentations, each emphasizing a slightly different aspect of sensory perception. The effects of aging on sensory processing, including auditory processing and speech perception, are not confined to older adults but begin in middle age in many cases.

  9. Cannabinoids and Vanilloids in Schizophrenia: Neurophysiological Evidence and Directions for Basic Research

    Directory of Open Access Journals (Sweden)

    Rafael N. Ruggiero

    2017-06-01

    Full Text Available Much of our knowledge of the endocannabinoid system in schizophrenia comes from behavioral measures in rodents, like prepulse inhibition of the acoustic startle and open-field locomotion, which are commonly used along with neurochemical approaches or drug challenge designs. Such methods continue to map fundamental mechanisms of sensorimotor gating, hyperlocomotion, social interaction, and underlying monoaminergic, glutamatergic, and GABAergic disturbances. These strategies will require, however, a greater use of neurophysiological tools to better inform clinical research. In this sense, electrophysiology and viral vector-based circuit dissection, like optogenetics, can further elucidate how exogenous cannabinoids worsen (e.g., tetrahydrocannabinol, THC or ameliorate (e.g., cannabidiol, CBD schizophrenia symptoms, like hallucinations, delusions, and cognitive deficits. Also, recent studies point to a complex endocannabinoid-endovanilloid interplay, including the influence of anandamide (endogenous CB1 and TRPV1 agonist on cognitive variables, such as aversive memory extinction. In fact, growing interest has been devoted to TRPV1 receptors as promising therapeutic targets. Here, these issues are reviewed with an emphasis on the neurophysiological evidence. First, we contextualize imaging and electrographic findings in humans. Then, we present a comprehensive review on rodent electrophysiology. Finally, we discuss how basic research will benefit from further combining psychopharmacological and neurophysiological tools.

  10. FORUM: Instructional Communication and Millennial Students: The Power of Language: A Constitutive Response to Millennial Student Research

    Science.gov (United States)

    Rudick, Kyle C.; Ellison, Scott

    2016-01-01

    In response to the articles in this forum, the authors write that they were struck by the way most of the authors assumed that generations are stable entities characterized by readily identifiable factors, such as age, attitudes or circumstances. Following a constitutive philosophy of communication and instruction (Fassett & Warren, 2007;…

  11. Safety approach and research and development presentation for the selected systems of the International forum Generation IV

    International Nuclear Information System (INIS)

    Fiorini, G.L.

    2003-01-01

    This paper deals with the six projects of the Generation IV forum: Sodium Fast reactor, lead fast reactor, gas fast reactor, very high temperature reactor, supercritical water reactor, molten salt reactor. The technical objectives of the reactor safety and the design/evaluation approach are discussed. (A.L.B.)

  12. Source memory errors in schizophrenia, hallucinations and negative symptoms: a synthesis of research findings.

    Science.gov (United States)

    Brébion, G; Ohlsen, R I; Bressan, R A; David, A S

    2012-12-01

    Previous research has shown associations between source memory errors and hallucinations in patients with schizophrenia. We bring together here findings from a broad memory investigation to specify better the type of source memory failure that is associated with auditory and visual hallucinations. Forty-one patients with schizophrenia and 43 healthy participants underwent a memory task involving recall and recognition of lists of words, recognition of pictures, memory for temporal and spatial context of presentation of the stimuli, and remembering whether target items were presented as words or pictures. False recognition of words and pictures was associated with hallucination scores. The extra-list intrusions in free recall were associated with verbal hallucinations whereas the intra-list intrusions were associated with a global hallucination score. Errors in discriminating the temporal context of word presentation and the spatial context of picture presentation were associated with auditory hallucinations. The tendency to remember verbal labels of items as pictures of these items was associated with visual hallucinations. Several memory errors were also inversely associated with affective flattening and anhedonia. Verbal and visual hallucinations are associated with confusion between internal verbal thoughts or internal visual images and perception. In addition, auditory hallucinations are associated with failure to process or remember the context of presentation of the events. Certain negative symptoms have an opposite effect on memory errors.

  13. Neuregulin 1: a prime candidate for research into gene-environment interactions in schizophrenia? Insights from genetic rodent models

    Directory of Open Access Journals (Sweden)

    Tim eKarl

    2013-08-01

    Full Text Available Schizophrenia is a multi-factorial disease characterized by a high heritability and environmental risk factors. In recent years, an increasing number of researchers worldwide have started investigating the ‘two-hit hypothesis’ of schizophrenia predicting that genetic and environmental risk factors (GxE interactively cause the development of the disorder. This work is starting to produce valuable new animal models and reveal novel insights into the pathophysiology of schizophrenia. This mini review will focus on recent advancements in the field made by challenging mutant and transgenic rodent models for the schizophrenia candidate gene neuregulin 1 (NRG1 with particular environmental factors. It will outline results obtained from mouse and rat models for various Nrg1 isoforms/isoform types (e.g. transmembrane domain Nrg1, Type II Nrg1, which have been exposed to different forms of stress (acute versus chronic, restraint versus social and housing conditions (standard laboratory versus minimally enriched housing. These studies suggest Nrg1 as a prime candidate for GxE interactions in schizophrenia rodent models and that the use of rodent models will enable a better understanding of GxE interactions and the underlying mechanisms.

  14. Consortium on the Genetics of Schizophrenia (COGS) assessment of endophenotypes for schizophrenia: an introduction to this Special Issue of Schizophrenia Research.

    Science.gov (United States)

    Swerdlow, Neal R; Gur, Raquel E; Braff, David L

    2015-04-01

    The COGS is a multi-site NIMH-sponsored investigation of the genetic basis of 12 primary and multiple secondary quantitative endophenotypes in schizophrenia. Since 2003, COGS has completed studies using a family-based ascertainment strategy (COGS-1), and a case-control ascertainment strategy (COGS-2) (cumulative "n">4000). COGS-1 family study confirmed robust deficits in, and heritability of, these endophenotypes in schizophrenia, and provided evidence for a coherent genetic architecture underlying the risk for neurocognitive and neurophysiological deficits in this disorder. COGS-2 case-control findings, many reported herein, establish a foundation for fine genomic mapping and other analyses of these endophenotypes and risk genes for SZ. Several reports in this Special Issue compare findings of endophenotype deficits generated by fundamentally different COGS-1 vs. COGS-2 ascertainment strategies. Despite the expectation that family-based and case-control designs would establish demographically and potentially biologically distinct patient cohorts, findings generally revealed comparable patterns of endophenotype deficits across studies. The COGS-2 case-control design facilitated the accrual of a larger "n", permitting detailed analyses of factors moderating endophenotype performance. Some COGS-2 endophenotypes not assessed in COGS-1 are also reported, as is a new factor analytic strategy for identifying shared vs. unique factors among the COGS endophenotypes which can be used to develop composite variables with distinct genetic signatures. The path to date of COGS-1 endophenotype and genetic findings, followed by replication and extension in COGS-2, establishes benchmarks for endophenotype deficits in SZ and their moderation by specific factors, and clear expectations for informative findings from upcoming COGS-2 genetic analyses. Published by Elsevier B.V.

  15. Correlation Between Insight and Capacity to Consent to Research in Subjects With Bipolar Disorder Type I and Schizophrenia.

    Science.gov (United States)

    López-Jaramillo, Carlos; Tobler, Chantal Aristizábal; Gómez, Constanza Ovalle; Triana, Jaime Escobar

    2016-01-01

    Schizophrenia and bipolar disorder type I (BD-I) can affect patient autonomy and capacity to consent to participate in research. Other variables associated with the autonomy of patients must be explored in order to improve the quality of the currently available tools. To evaluate the relationship between insight and the capacity to consent to participate in research in patients with BD-I and schizophrenia. A cross-sectional and longitudinal study was conducted with 120 subjects (40 subjects with schizophrenia, 40 with BD-I, and 40 healthy controls). The tools used were the Scale Assessment Insight-Expanded (SAI-E) and the MacArthur Competence Assessment Tool-Treatment (MacCAT-CR), which was first adapted culturally, and its validity and reliability assessed. The results obtained on each scale were compared and the association between them were evaluated. There is a direct correlation between the capacity to consent to research, measured using the MacCAT-CR tool, and the degree of insight, measured using the SAI-E scale, with an effect size of 1.3 for BD-I and 2.03 for schizophrenia. The results suggest that there is a correlation between the degree of insight and the capacity to consent to research in subjects with schizophrenia and BD-I. Insight should therefore be included as a relevant variable to assess the capacity to consent, and future studies should include it when researching on or designing new tools which aim at a greater respect of patient autonomy. Copyright © 2016 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

  16. Considering a frame of reference for physical activity research related to the cardiometabolic risk profile in schizophrenia.

    Science.gov (United States)

    Vancampfort, Davy; Knapen, Jan; Probst, Michel; van Winkel, Ruud; Deckx, Seppe; Maurissen, Katrien; Peuskens, Joseph; De Hert, Marc

    2010-05-30

    This article reviews evidence that researchers and mental health service providers need to take into account four modifiable factors that affect the prevalence of the metabolic syndrome in people with schizophrenia: (a) physical activity as part of a health-related lifestyle, (b) physical fitness, (c) mental health status and (d) antipsychotic medication. The implementation of physical activity in order to prevent and treat cardiometabolic risk factors in people with schizophrenia is discussed. English language articles published until July 2009 were identified by PubMed, CINAHL, PsychINFO, and Cochrane Central Register of Controlled Trials. The search terms schizophrenia and metabolic syndrome, physical activity, health, fitness, and lifestyle were used. Physical activity interventions result in positive effects on metabolic outcomes, physical fitness, health-related behavior and mental health. Considering present knowledge, physical therapists should take into account the emotional (negative symptoms, self-esteem, self-efficacy, and stress) and physiological (cardiometabolic parameters) components of mental illness when offering physical activity interventions. The physical activity stimulus should be adapted to the individual's physical fitness level and the side effects of the antipsychotic medications. More research is needed to assist in the practical development of effective evidence-based preventive and curative strategies in psychiatric services for metabolic syndrome in persons with schizophrenia. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

  17. Social Cognitive Training for Schizophrenia: A Meta-Analytic Investigation of Controlled Research

    Science.gov (United States)

    Kurtz, Matthew M.; Richardson, Christi L.

    2012-01-01

    A wealth of evidence has revealed that deficits in social cognitive skills (including facial affect recognition (FAR), social cue perception, Theory of Mind (ToM), and attributional style) are evident in schizophrenia and are linked to a variety of domains of functional outcome. In light of these associations, a growing number of studies have attempted to ameliorate these deficits as a means of improving outcome in the disorder through the use of structured behavioral training. This study used quantitative methods of meta-analysis to assess the efficacy of behavioral training programs designed to improve social cognitive function. A total of 19 studies consisting of 692 clients were aggregated from relevant databases. Outcome measures were organized according to whether they were social cognitive tests proximal to the intervention or whether they represented measures of treatment generalization (symptoms, observer-rated community, and institutional function). With respect to social cognitive measures, weighted effect-size analysis revealed that there were moderate-large effects of social cognitive training procedures on FAR (identification, d = 0.71 and discrimination, d = 1.01) and small-moderate effects of training on ToM (d = 0.46), while effects on social cue perception and attributional style were not significant. For measures of generalization, weighted effect-size analysis revealed that there were moderate-large effect on total symptoms (d = 0.68) and observer-rated community and institutional function (d = 0.78). Effects of social cognitive training programs on positive and negative symptoms of schizophrenia were nonsignificant. Moderating variables and implications for future research and treatment development are discussed. PMID:21525166

  18. Biological study in schizophrenia

    International Nuclear Information System (INIS)

    Kasai, Kiyoto; Yoshikawa, Akane; Natsubori, Takanobu; Koike, Shinsuke; Nagai, Tatsuya; Araki, Tsuyoshi; Nishimura, Yukika; Iwamoto, Kazuya

    2012-01-01

    Schizophrenia is associated with enormous morbidity, mortality, personal disability, and social cost. Although considerable research on schizophrenia has been performed, the etiology of this disease has not been fully elucidated. In recent years, imaging and genetic technologies have been developed dramatically. Disturbances in glutamate and gamma-aminobutyric acid (GABA)ergic neurotransmission may underlie the pathophysiology of schizophrenia. We attempted an integrative review, of studies pertaining to recent advances of schizophrenia research with a focus on neuroimaging and genetic studies. Additionally, we present the preliminary findings of the clinical research in our outpatient unit, specialized for early intervention, at the University of Tokyo Hospital. (author)

  19. Lighting detectives forum

    DEFF Research Database (Denmark)

    Bülow, Katja; Skindbjerg Kristensen, Lisbeth

    2003-01-01

    Belysning for boligområder var emnet for lighting detectives forum, der blev afholdt i Stockholm i august 2003.......Belysning for boligområder var emnet for lighting detectives forum, der blev afholdt i Stockholm i august 2003....

  20. The forum as a friend: parental mental illness and communication on open Internet forums.

    Science.gov (United States)

    Widemalm, My; Hjärthag, Fredrik

    2015-10-01

    The aim of this study was to identify how daughters or sons to parents suffering from mental illness perceive their situation. The objective was to provide new knowledge based on what they communicate on open Internet forums. The sample consisted of forum posts written by individuals who reported that they had mentally ill parents. Data collection comprised 301 comments from 35 forum threads on 5 different Swedish Internet forums, and predetermined inclusion criteria were used. Data were analyzed qualitatively using thematic analysis. The analysis generated four themes: "Caregiver burden," "Knowledge seeking," "Support from the forum," and "Frustration and powerlessness over health care." The results showed that parents' mental illness affected the forum writers on several levels, and they often felt stigmatized. The writers often lacked knowledge of their parents' mental illness and sought out Internet forums for information and support from peers in similar situations. The psychiatric care given to the parents was a source of dissatisfaction among the forum writers, who often felt that their parents did not receive adequate care. This study shows that fear of stigmatization and perceived lack of care and support caused forum writers to anonymously seek out Internet forums for information and support from others with similar experiences. The role of social support and the attractiveness of anonymity and availability typical for open Internet forums ought to be considered by health care professionals and researchers when developing new ways for providing support for children or adolescents with a mentally ill parent.

  1. Journalism Forum.

    Science.gov (United States)

    Journalism Educator, 1982

    1982-01-01

    Journalism teachers share ideas about copywriting assignments, research in public relations, student involvement in a television production, and the use of journalism classes to monitor language skills. (HOD)

  2. FY 2000 report on the promotion projects by Research Institute of Innovative Technology for the Earth. Proceedings of the international seminar (Reports presented to the international forum held by RITE); 2000 nendo chikyu kankyo sangyo gijutsu kaihatsu suishihn jigyo kokusai seminar shiryo. RITE chikyu kankyo kokusai forum hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    Research Institute of Innovative Technology for the Earth (RITE) has been inviting creative, advanced research projects still in the early stage on an international scale to raise the research seeds for global environment preservation, and promoting the selected themes. The organization has invited the domestic authorities and researchers for the research projects selected from abroad as the good projects in the areas of biology and chemistry, to hold the international forum in March 2001. The keynote lecture in the area of biology addresses the latest researches on plant and life science, stressing how the researches contribute to global environmental problems. The keynote lecture in the area of chemistry addresses possibility of establishment of energy resource cycles utilizing the natural force of the earth. The last lecture introduces the research results by the environmental catalyst research group of RITE. The forum has animated questions and answers in the lectures selected as the good research projects. (NEDO)

  3. Male circumcision for HIV prevention in Papua New Guinea: a summary of research evidence and recommendations for public health following a national policy forum.

    Science.gov (United States)

    Vallely, A; MacLaren, D J; Kaleva, W; Millan, J; Tommbe, R; Marape, W; Manineng, C; Buchanan, H; Amos, A; Frank, R; Kelly, A; Kupul, M; Aeno, H; Trowalle, E; John, L N; Redman-Maclaren, M L; Ryan, C; Browne, K; Tynan, A; Hill, P S; Gray, R T; Murray, J; Wilson, D P; Law, G; Siba, P; McBride, W J H; Farley, T; Kaldor, J M

    2011-01-01

    In 2005, a clinical trial in South Africa found that circumcision of young men could reduce their risk of acquiring HIV (human immunodeficiency virus) infection by over 60%. In the following year, two more trials in Africa confirmed this finding, leading the World Health Organization to recommend male circumcision as a public health strategy for HIV prevention in high-incidence countries. In order to inform public health policy in Papua New Guinea (PNG), two major research projects were initiated with the goals of investigating the status of penile cutting practices and assessing understandings, acceptability, feasibility and cost-effectiveness of male circumcision for HIV prevention. In addition, behavioural surveillance surveys systematically asked questions on penile cutting practices and an ethnographic literature review informed historical perspectives of penile cutting in PNG. Key findings from these research activities were presented at a National Policy Forum on Male Circumcision for HIV Prevention held in Port Moresby in November 2011. The Forum made three key recommendations: (1) the formation of a joint National Department of HealthlNational AIDS Council Secretariat Policy Committee on male circumcision; (2) the establishment of an integrated harm reduction program; and (3) that future policy on wide-scale roll-out of male circumcision for HIV prevention in PNG be informed by a combination of data from (a) male circumcision intervention pilot programs and (b) research on the potential protective effect of other forms of penile cutting.

  4. SAMJ FORUM

    African Journals Online (AJOL)

    2006-09-01

    Sep 1, 2006 ... children which he called 'standing in the queue for asthma'. This phenomemon is now ... He developed a simple clinical test to determine ... services and research expanded rapidly and the clinic soon gained national and ...

  5. Energy Frontier Research Center Materials Science of Actinides (A 'Life at the Frontiers of Energy Research' contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

    International Nuclear Information System (INIS)

    Burns, Peter

    2011-01-01

    'Energy Frontier Research Center Materials Science of Actinides' was submitted by the EFRC for Materials Science of Actinides (MSA) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. MSA is directed by Peter Burns at the University of Notre Dame, and is a partnership of scientists from ten institutions.The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.

  6. 2008 GRS specialized forum

    International Nuclear Information System (INIS)

    Butz, H.P.

    2008-01-01

    After the successful trial run in 2007, the 2008 GRS Specialized Forum held at the Cologne Wolkenburg on April 7 and 8, 2008 was a full success. GRS, Gesellschaft fuer Anlagen- und Reaktorsicherheit, plans to resume in this way its GRS specialized lectures series with a tradition of many years. Approximately 180 participants from public authorities, licensees, the nuclear industry, research and engineering establishments as well as universities showed their interest in current GRS activities. On 2 days, only GRS experts presented fundamental and GRS-specific approaches in scientific analysis, new research findings, and possibilities of advancing scientific methods under the four headings of Reactor Safety Research and Evaluation, Topical Subjects of Reactor Safety, Radiation Protection Activities, and Repository Safety and Environmental Research. The discussions held after each presentation offered a number of critical, but valuable and welcome, contributions from the different perspectives of the discussants. (orig.)

  7. The Danish Schizophrenia Registry

    DEFF Research Database (Denmark)

    Baandrup, Lone; Cerqueira, Charlotte; Haller, Lea

    2016-01-01

    Aim of database: To systematically monitor and improve the quality of treatment and care of patients with schizophrenia in Denmark. In addition, the database is accessible as a resource for research. Study population: Patients diagnosed with schizophrenia and receiving mental health care...... to the data for use in specific research projects by applying to the steering committee. Conclusion: The Danish Schizophrenia Registry represents a valuable source of informative data to monitor and improve the quality of care of patients with schizophrenia in Denmark. However, continuous resources and time...

  8. Science Forum of the renewables 2004: Networked knowledge for renewable energies - Research, development and education - Basis for wide-spread deployment of renewable energies. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Wienges, S.; Stadermann, G.; Szczepanski, P. (eds.)

    2004-09-01

    Energy was one of five foci of the World Summit on Sustainable Development (WSSD) in Johannesburg in 2002. While the access to modern energy is crucial for poverty reduction in particular and development in general, the way of producing and providing that energy is as crucial for environmental and social sustainability. Hence, the renewables 2004 - the International Conference for Renewable Energies was the logical consequence and next step on the way forward. It was held from 1st June to 4th June 2004 in Bonn, Germany, and turned out to be a forum for stakeholders from all sectors: Governments as well as parliamentarians, the private sector, NGOs, International Organisations, and International Financial Institutions. On 1st June this multisectoral approach to the dissemination of renewables was completed by the Science Forum - Education, Research, and Training: Basis for Wide-spread Deployment of Renewable Energies. This one-day side-event brought together scientists and practitioners from allover the world, discussing the future requirements of research and development as well as needs and potentials of education and training for renewables in developing and industrialized countries. (orig.)

  9. Journalism Forum

    Science.gov (United States)

    Journalism Educator, 1985

    1985-01-01

    Includes (1) survey results indicating value of traditional journalism and mass communication research; (2) survey results indicating knowledge of grammar, economics, and government are journalists' most valuable resources; (3) methods for teaching listening skills; (4) suggestions for giving public relations students an overview online services;…

  10. THE 3rd SCHIZOPHRENIA INTERNATIONAL RESEARCH SOCIETY CONFERENCE, 14-18 APRIL 2012, FLORENCE, ITALY: SUMMARIES OF ORAL SESSIONS

    Science.gov (United States)

    Abbs, Brandon; Achalia, Rashmin M; Adelufosi, Adegoke O; Aktener, Ahmet Yiğit; Beveridge, Natalie J; Bhakta, Savita G; Blackman, Rachael K; Bora, Emre; Byun, MS; Cabanis, Maurice; Carrion, Ricardo; Castellani, Christina A; Chow, Tze Jen; Dmitrzak-Weglarz, M; Gayer-Anderson, Charlotte; Gomes, Felipe V; Haut, Kristen; Hori, Hiroaki; Kantrowitz, Joshua T; Kishimoto, Taishiro; Lee, Frankie HF; Lin, Ashleigh; Palaniyappan, Lena; Quan, Meina; Rubio, Maria D; Ruiz de Azúa, Sonia; Sahoo, Saddichha; Strauss, Gregory P; Szczepankiewicz, Aleksandra; Thompson, Andrew D; Trotta, Antonella; Tully, Laura M; Uchida, Hiroyuki; Velthorst, Eva; Young, Jared W; O’Shea, Anne; DeLisi, Lynn E.

    2013-01-01

    The 3rd Schizophrenia International Research Society Conference was held in Florence, Italy, April 14-18, 2012.and this year had as its emphasis, “The Globalization of Research”. Student travel awardees served as rapporteurs for each oral session and focused their summaries on the most significant findings that emerged and the discussions that followed. The following report is a composite of these summaries. We hope that it will provide an overview for those who were present, but could not participate in all sessions, and those who did not have the opportunity to attend, but who would be interested in an update on current investigations ongoing in the field of schizophrenia research. PMID:22910407

  11. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996. Photo 01: Thérèse Wolf, Secretary of Forum Engelberg; Alain Hervé; Horst Wenninger; and Alexander Höchli, Forum member and former Landammann of the canton of Obwalden, at the CMS detector's assembly site.

  12. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996. He is seen here (right) in discussion with Bernard Ecoffey, Founder of the Forum Engelberg.

  13. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996. He is pictured here (right) alongside CERN Director-General Prof. Luciano Maiani during the visit of Forum members to CERN.

  14. LLW Forum meeting report

    International Nuclear Information System (INIS)

    1996-01-01

    This report summarizes the Low-Level Radioactive Waste Forum (LLW Forum) meeting on May 29 through May 31, 1996.The LLW Forum is an association of state and compact representatives, appointed by governors and compact commissions, established to facilitate state and compact implementation of the Low-Level Waste Policy Act of 1980 and the Low-Level Radioactive Waste Policy Amendments Act of 1985 and to promote the objectives of low-level radioactive waste regional compacts. The LLW forum provides an opportunity for state and compact officials to share information with one another and to exchange views with officials of federal agencies and other interested parties

  15. LLW Forum meeting report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    This report summarizes the Low-Level Radioactive Waste Forum (LLW Forum) meeting on May 29 through May 31, 1996.The LLW Forum is an association of state and compact representatives, appointed by governors and compact commissions, established to facilitate state and compact implementation of the Low-Level Waste Policy Act of 1980 and the Low-Level Radioactive Waste Policy Amendments Act of 1985 and to promote the objectives of low-level radioactive waste regional compacts. The LLW forum provides an opportunity for state and compact officials to share information with one another and to exchange views with officials of federal agencies and other interested parties.

  16. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrive Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996. Photo 01: CERN Director-General Prof. Luciano Maiani (left) speaks to Forum members and public figures from the Geneva area during the visit. In the background is Jean-Claude Landry from the Department of the Interior, Agriculture and Environment, State of Geneva. Photo 02: CERN Director-General Prof. Luciano Maiani (left) speaks to Forum members and public figures from the Geneva area during the visit. In the background is Bernard Ecoffey, Founder of the Forum Engelberg.

  17. The South African Forum for Radiation Protection

    International Nuclear Information System (INIS)

    Basson, J.K.; Le Roux, P.R.

    1993-01-01

    The use of ionising radiation in South Africa since the turn of the century was initially limited to x-rays and radium, with predominant applications in medicine for diagnosis and therapy. Since 1948 artificial radio-isotopes have been increasingly available and such applications have been widely extended to industry, agriculture and science. Initially, the Council for Scientific and Industrial Research developed radiation protection in South Africa. It was later recommended that an independent forum, the South African Forum for Radiation Protection, be established. The activities of the Forum are described

  18. Cognitive Remediation in Schizophrenia

    Directory of Open Access Journals (Sweden)

    Joana Vieira

    2014-06-01

    Full Text Available Several reviews of the literature support the idea that cognitive deficits observed in a large percentage of patients with schizophrenia are responsible for the cognitive performance deficit and functional disability associated with the disease. The grow- ing importance of neurocognition in Psychiatry, especially with regard to planning strategies and rehabilitative therapies to improve the prognosis of patients contrib- utes to the interest of achieving this literature review on cognitive rehabilitation in schizophrenia. In this work, drawn from research in the areas of schizophrenia, cog- nition, cognitive rehabilitation and cognitive remediation (2000-2012 through PubMed and The Cochrane Collaboration, it is intended, to describe the types of psychological and behavioral therapies recommended in the treatment of cognitive disabilities in patients diagnosed with schizophrenia. This review will also highlight the clinical and scientific evidence of each of these therapies, as their effect on cognitive performance, symptoms and functionality in patients with schizophrenia.

  19. Jung's views on causes and treatments of schizophrenia in light of current trends in cognitive neuroscience and psychotherapy research I. Aetiology and phenomenology.

    Science.gov (United States)

    Silverstein, Steven M

    2014-02-01

    Jung's writings on schizophrenia are almost completely ignored or forgotten today. The purpose of this paper, along with a follow-up article, is to review the primary themes found in Jung's writings on schizophrenia, and to assess the validity of his theories about the disorder in light of our current knowledge base in the fields of psychopathology, cognitive neuroscience and psychotherapy research. In this article, five themes related to the aetiology and phenomenology of schizophrenia from Jung's writings are discussed:1) abaissement du niveau mental; 2) the complex; 3) mandala imagery; 4) constellation of archetypes and 5) psychological versus toxic aetiology. Reviews of the above areas suggest three conclusions. First, in many ways, Jung's ideas on schizophrenia anticipated much current thinking and data about the disorder. Second, with the recent (re)convergence of psychological and biological approaches to understanding and treating schizophrenia, the pioneering ideas of Jung regarding the importance of both factors and their interaction remain a useful and rich, but still underutilized resource. Finally, a more concerted effort to understand and evaluate the validity of Jung's concepts in terms of evidence from neuroscience could lead both to important advances in analytical psychology and to developments in therapeutic approaches that would extend beyond the treatment of schizophrenia. © 2014, The Society of Analytical Psychology.

  20. Treatment-Resistant Schizophrenia

    DEFF Research Database (Denmark)

    Howes, Oliver D; McCutcheon, Rob; Agid, Ofer

    2017-01-01

    OBJECTIVE: Research and clinical translation in schizophrenia is limited by inconsistent definitions of treatment resistance and response. To address this issue, the authors evaluated current approaches and then developed consensus criteria and guidelines. METHOD: A systematic review of randomize...

  1. The Center for Frontiers of Subsurface Energy Security (A 'Life at the Frontiers of Energy Research' contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

    International Nuclear Information System (INIS)

    Pope, Gary A.

    2011-01-01

    'The Center for Frontiers of Subsurface Energy Security (CFSES)' was submitted to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. CFSES is directed by Gary A. Pope at the University of Texas at Austin and partners with Sandia National Laboratories. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.

  2. Rethinking Schizophrenia

    OpenAIRE

    Insel, Thomas R.

    2010-01-01

    How will we view schizophrenia in 2030? Schizophrenia today is a chronic, frequently disabling mental disorder that affects about one per cent of the world's population. After a century of studying schizophrenia, the cause of the disorder remains unknown. Treatments, especially pharmacological treatments, have been in wide use for nearly half a century, yet there is little evidence that these treatments have substantially improved outcomes for most people with schizophrenia. These current uns...

  3. The Czechoslovak nuclear forum

    International Nuclear Information System (INIS)

    Kadlec, J.

    1992-01-01

    The Czechoslovak Nuclear Forum is a civic initiative that is involved with the safe, economically efficient and generally acceptable development of nuclear power. Its efforts are aimed at incorporation into a broader European context. The Forum is a FORATOM member organization. Its activities are intended to contribute to the establishment of a favorable climate for a further progress of nuclear power in elected bodies (Parliament, municipal and district authorities), in mass media and among the public. (M.D.)

  4. [Risk factors of schizophrenia].

    Science.gov (United States)

    Suvisaari, Jaana

    2010-01-01

    Schizophrenia is a multifactorial, neurodevelopmental disorder caused by a combination of genetic and environmental risk factors. Disturbances of brain development begin prenatally, while different environmental insults further affect postnatal brain maturation during childhood and adolescence. Genome-wide association studies (GWAS) have succeeded in identifying hundreds of new risk variants for common, multifactorial diseases. In schizophrenia research, GWAS have found several rare copy number variants that considerably increase the risk of schizophrenia, and have shown an association between schizophrenia and the major histocompatibility complex. Research on environmental risk factors in recent years has provided new information particularly on risk factors related to pregnancy and childhood rearing environment. Gene-environment interactions have become a central research topic. There is evidence that genetically susceptible children are more vulnerable to the effects of unstable childhood rearing environment and other environmental risk factors.

  5. THE 4th SCHIZOPHRENIA INTERNATIONAL RESEARCH SOCIETY CONFERENCE, 5–9 APRIL 2014, FLORENCE, ITALY: A summary of topics and trends

    Science.gov (United States)

    Abayomi, Olukayode; Amato, Davide; Bailey, Candace; Bitanihirwe, Byron; Bowen, Lynneice; Burshtein, Shimon; Cullen, Alexis; Fusté, Montserrat; Herrmann, Ana P; Khodaie, Babak; Kilian, Sanja; Lang, Qortni A; Manning, Elizabeth E; Massuda, Raffael; Nurjono, Milawaty; Sadiq, Sarosh; Sanchez-Gutierrez, Teresa; Sheinbaum, Tamara; Shivakumar, Venkataram; Simon, Nicholas; Spiteri-Staines, Anneliese; Sirijit, Suttajit; Toftdahl, Nanna Gilliam; Wadehra, Sunali; Wang, Yi; Wigton, Rebekah; Wright, Susan; Yagoda, Sergey; Zaytseva, Yuliya; O’Shea, Anne; DeLisi, Lynn E.

    2015-01-01

    The 4th Schizophrenia International Research Society Conference was held in Florence, Italy, April 5–9, 2014.and this year had as its emphasis, “Fostering Collaboration in Schizophrenia Research”. Student travel awardees served as rapporteurs for each oral session, summarized the important contributions of each session and then each report was integrated into a final summary of data discussed at the entire conference by topic. It is hoped that by combining data from different presentations, patterns of interest will emerge and thus lead to new progress for the future. In addition, the following report provides an overview of the conference for those who were present, but could not participate in all sessions, and those who did not have the opportunity to attend, but who would be interested in an update on current investigations ongoing in the field of schizophrenia research. PMID:25306204

  6. Visual masking & schizophrenia

    Directory of Open Access Journals (Sweden)

    Michael H. Herzog

    2015-06-01

    Full Text Available Visual masking is a frequently used tool in schizophrenia research. Visual masking has a very high sensitivity and specificity and masking paradigms have been proven to be endophenotypes. Whereas masking is a powerful technique to study schizophrenia, the underlying mechanisms are discussed controversially. For example, for more than 25 years, masking deficits of schizophrenia patients were mainly attributed to a deficient magno-cellular system (M-system. Here, we show that there is very little evidence that masking deficits are magno-cellular deficits. We will discuss the magno-cellular and other approaches in detail and highlight their pros and cons.

  7. Surgical Management of Obesity Among People with Schizophrenia and Bipolar Disorder: a Systematic Review of Outcomes and Recommendations for Future Research.

    Science.gov (United States)

    Kouidrat, Youssef; Amad, Ali; Stubbs, Brendon; Moore, Suzan; Gaughran, Fiona

    2017-07-01

    People with schizophrenia or bipolar disorder (BD) exhibit very high levels of obesity. Little is known about the potential benefits/risks of obesity surgery. We conducted a narrative review to summarize the available knowledge on bariatric surgery in people with schizophrenia or BD. A systematic search was conducted of major electronic databases from inception to October 2016 for studies investigating bariatric surgery among people with schizophrenia or BD. Data were presented in a narrative synthesis and future research strategies proposed. The electronic database searches identified 44 records. Eight studies (BD, n = 265; schizophrenia: n = 14) were included with a mean study length of 15.7 months (12-24). Seven found that bariatric surgery resulted in weight loss in those with psychiatric disorders with an excess weight loss ranging -31 to -70%. Six studies found that weight loss from bariatric surgery was similar in people with schizophrenia or BD versus controls. However, most of the studies limited their outcomes to only weight loss and did not measure whether obesity surgery affected the status and treatment of psychiatric symptoms. Although few adverse events were reported among patients with BD, data from two studies demonstrated no significant deterioration of psychiatric symptoms post-surgery in people with schizophrenia. Growing evidence suggests that bariatric surgery may improve short-term weight status among people with BD. However, given the paucity of studies for schizophrenia, and the lack of information on medium-to long-term results, future large-scale high-quality studies are required.

  8. Candidate genes and favoured loci: strategies for molecular genetic research into schizophrenia, manic depression, autism, alcoholism and Alzheimer's disease.

    Science.gov (United States)

    Gurling, H

    1986-01-01

    It is argued that further research to achieve more detailed diagnostic systems in many psychiatric disorders is unlikely to be productive without taking genetic effects into account. Even when this is done, for example when carrying out segregation analysis to determine a mode of genetic transmission, mental illnesses often pose specific problems that preclude accurate analysis. Because techniques in molecular biology and genetics have made it possible to study gene effects in human disease systematically it should now be possible to specify the genes that are involved. When this has been achieved then a diagnostic system based on genetic causation can develop. This will have the advantage of helping to pinpoint environmental factors more accurately. Specific strategies will need to be adopted to overcome uncertain modes of inheritance, incomplete or non-penetrance of disease alleles and disease heterogeneity. Highly speculative hypotheses can be put forward for a locus causing Alzheimer's disease on a portion of the long arm of chromosome 21. For autism it is plausible that there is a disease locus at or near the fragile X site on the X chromosome. A locus for manic depression has been very tentatively mapped using DNA markers to chromosome 11 and in a small proportion of families DNA markers have also shown some evidence for X linkage. Schizophrenia does not seem to be associated with any favoured loci. Candidate genes for schizophrenia include those encoding dopamine, other neurotransmitter receptors or enzymes and various neuropeptides such as enkephalin and beta endorphin.

  9. Measuring the construct of executive control in schizophrenia: defining and validating translational animal paradigms for discovery research.

    Science.gov (United States)

    Gilmour, Gary; Arguello, Alexander; Bari, Andrea; Brown, Verity J; Carter, Cameron; Floresco, Stan B; Jentsch, David J; Tait, David S; Young, Jared W; Robbins, Trevor W

    2013-11-01

    Executive control is an aspect of cognitive function known to be impaired in schizophrenia. Previous meetings of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) group have more precisely defined executive control in terms of two constructs: "rule generation and selection", and "dynamic adjustments of control". Next, human cognitive tasks that may effectively measure performance with regard to these constructs were identified to be developed into practical and reliable measures for use in treatment development. The aim of this round of CNTRICS meetings was to define animal paradigms that have sufficient promise to warrant further investigation for their utility in measuring these constructs. Accordingly, "reversal learning" and the "attentional set-shifting task" were nominated to assess the construct of rule generation and selection, and the "stop signal task" for the construct of dynamic adjustments of control. These tasks are described in more detail here, with a particular focus on their utility for drug discovery efforts. Presently, each assay has strengths and weaknesses with regard to this point and increased emphasis on improving practical aspects of testing, understanding predictive validity, and defining biomarkers of performance represent important objectives in attaining confidence in translational validity here. Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.

  10. Nuclear systems of the future: international forum generation 4 and research and development projects at the Cea

    International Nuclear Information System (INIS)

    Carre, F.

    2003-01-01

    To advance nuclear energy to meet future energy needs, ten countries have agreed to develop a future generation of nuclear energy systems, known as Generation 4. A technology road map to guide the Generation 4 effort was begun. This document presents the goals for these nuclear systems and the research programs of the Cea on the gas technology, GT-MHR, VHTR and GFR and the other systems as sodium Fast Neutron reactors, supercritical water and space nuclear. (A.L.B.)

  11. NEUROPSYCHOLOGY OF SCHIZOPHRENIA

    OpenAIRE

    Hugo Selma Sánchez

    2008-01-01

    Neuropsychology has had an explosive grow in the last decades. It contributions to the fields of Psychiatry are growing in an exponential rate. Research related to schizophrenia has bringing new views of the nature of the disease, at the same time offering contradictions and questions pending to resolve. The present article exposes the most relevant discoveries in the neuropshychology of schizophrenia neuroanatomy dysfunctions, development neurofuntionality, alterations in neurotransmitters a...

  12. NEUROPSYCHOLOGY OF SCHIZOPHRENIA

    Directory of Open Access Journals (Sweden)

    Hugo Selma Sánchez

    2008-11-01

    Full Text Available Neuropsychology has had an explosive grow in the last decades. It contributions to the fields of Psychiatry are growing in an exponential rate. Research related to schizophrenia has bringing new views of the nature of the disease, at the same time offering contradictions and questions pending to resolve. The present article exposes the most relevant discoveries in the neuropshychology of schizophrenia neuroanatomy dysfunctions, development neurofuntionality, alterations in neurotransmitters and cognitive deficiencies and areas for exploring.

  13. Long-term maternal recall of obstetric complications in schizophrenia research.

    LENUS (Irish Health Repository)

    Walshe, Muriel

    2011-05-30

    Obstetric complications (OCs) are consistently implicated in the aetiology of schizophrenia. Information about OCs is often gathered retrospectively, from maternal interview. It has been suggested that mothers of people with schizophrenia may not be accurate in their recollection of obstetric events. We assessed the validity of long term maternal recall by comparing maternal ratings of OCs with those obtained from medical records in a sample of mothers of offspring affected and unaffected with psychotic illness. Obstetric records were retrieved for 30 subjects affected with psychosis and 40 of their unaffected relatives. The Lewis-Murray scale of OCs was completed by maternal interview for each subject blind to the obstetric records. There was substantial agreement between maternal recall and birth records for the summary score of "definite" OCs, birth weight, and most of the individual items rated, with the exception of antepartum haemorrhage. There were no significant differences in the validity of recall or in errors of commission by mothers for affected and unaffected offspring. These findings indicate that several complications of pregnancy and delivery are accurately recalled by mother\\'s decades after they occurred. Furthermore, there is no indication that mothers are less accurate in recalling OCs for their affected offspring than their unaffected offspring. When comparing women with and without recall errors, we found those with recall errors to have significantly worse verbal memory than women without such errors. Assessing the cognition of participants in retrospective studies may allow future studies to increase the reliability of their data.

  14. The neurobiology of social environmental risk for schizophrenia: an evolving research field.

    Science.gov (United States)

    Akdeniz, Ceren; Tost, Heike; Meyer-Lindenberg, Andreas

    2014-04-01

    Schizophrenia is a severe and complex brain disorder that usually manifests in early adulthood and disturbs a wide range of human functions. More than 100 years after its initial description, the pathophysiology of the disorder is still incompletely understood. Many epidemiological studies strongly suggest a complex interaction between genetic and environmental risk factors for the development of the disorder. While there is considerable evidence for a social environmental component of this risk, the links between adverse social factors and altered brain function have just come into focus. In the present review, we first summarize epidemiological evidence for the significance of social environmental risk factors, outline the role of altered social stress processing in mental illness, and review the latest experimental evidence for the neural correlates of social environmental risk for schizophrenia. The studies we have discussed in this review provide a selection of the current work in the field. We suggest that many of the social environmental risk factors may impact on perceived social stress and engage neural circuits in the brain whose functional and structural architecture undergoes detrimental change in response to prolonged exposure. We conclude that multidisciplinary approaches involving various fields and thoroughly constructed longitudinal designs are necessary to capture complex structure of social environmental risks.

  15. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996. Horst Wenninger (left) in animated discussion with Alexander Höchli, member of the Institutional Committee of Forum Engelberg and former Landammann of the canton of Obwalden.

  16. Drug-Induced Psychosis: How to Avoid Star Gazing in Schizophrenia Research by Looking at More Obvious Sources of Light

    OpenAIRE

    Paparelli, Alessandra; Di Forti, Marta; Morrison, Paul D.; Murray, Robin M.

    2011-01-01

    The prevalent view today is that schizophrenia is a syndrome rather than a specific disease. Liability to schizophrenia is highly heritable. It appears that multiple genetic and environmental factors operate together to push individuals over a threshold into expressing the characteristic clinical picture. One environmental factor which has been curiously neglected is the evidence that certain drugs can induce schizophrenia-like psychosis. In the last 60 years, improved understanding of the re...

  17. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996.Seated here at a presentation by Peter Jenni, spokesperson for the ATLAS collaboration, during the visit of Forum members and Geneva public figures are Bernard Ecoffey, Founder of the Forum Engelberg (left), and Jean-Claude Landry, Department of the Interior, Agriculture and Environment, state of Geneva. Photo 01: (left to right) Bernard Ecoffey, Jean-Claude Landry and Peter Jenni. Photos 02, 03: (left to right) Jean-Claude Landry, Bernard Ecoffey and Peter Jenni.

  18. Proceedings of the 2008 air issues forum

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    This forum focused on air related issues of concern to the oil and gas industry, regulators, researchers and the public. It included technological advances, new research projects, case studies, demonstrations, and updates to environmental regulations. Both the provincial and federal governments have recently announced new and significant reduction targets for air emissions that will have impacts on upstream oil and gas (UOG) companies. This forum reviewed what has been proposed and why and outlined the potential implications for producers. New regulatory processes and their requirements were also discussed along with ongoing industry sponsored air related research and emerging air related issues such as soot formation during flaring, sour gas flare combustion simulation modelling and fugitive emissions reduction. Ten presentations were featured at this forum, of which 3 have been catalogued separately for inclusion in this database. tabs. figs.

  19. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996. Photo 01: Raymond Battistella - Director-General of SIG, Geneva's utilities provider (left) - and Bernard Ecoffey, Founder of the Forum Engelberg. In the background is the CMS magnet system under construction. The red concentric rings are part of the barrel yoke, which returns the magnetic flux generated by the superconducting coil. Supported from the innermost barrel ring is the outer cylinder of the vacuum tank that will house the superconducting coil. Photo 02: Alexander Höchli, member of the Institutional Committee of Forum Engelberg and former Landammann of the canton of Obwalden (left), with Raymond Battistella, Di...

  20. Proceedings of the 2008 air issues forum

    International Nuclear Information System (INIS)

    2008-01-01

    This forum focused on air related issues of concern to the oil and gas industry, regulators, researchers and the public. It included technological advances, new research projects, case studies, demonstrations, and updates to environmental regulations. Both the provincial and federal governments have recently announced new and significant reduction targets for air emissions that will have impacts on upstream oil and gas (UOG) companies. This forum reviewed what has been proposed and why and outlined the potential implications for producers. New regulatory processes and their requirements were also discussed along with ongoing industry sponsored air related research and emerging air related issues such as soot formation during flaring, sour gas flare combustion simulation modelling and fugitive emissions reduction. Ten presentations were featured at this forum, of which 3 have been catalogued separately for inclusion in this database. tabs. figs

  1. The Accelerator Reliability Forum

    CERN Document Server

    Lüdeke, Andreas; Giachino, R

    2014-01-01

    A high reliability is a very important goal for most particle accelerators. The biennial Accelerator Reliability Workshop covers topics related to the design and operation of particle accelerators with a high reliability. In order to optimize the over-all reliability of an accelerator one needs to gather information on the reliability of many different subsystems. While a biennial workshop can serve as a platform for the exchange of such information, the authors aimed to provide a further channel to allow for a more timely communication: the Particle Accelerator Reliability Forum [1]. This contribution will describe the forum and advertise it’s usage in the community.

  2. Paradigm shift in consciousness research: the child's self-awareness and abnormalities in autism, ADHD and schizophrenia.

    Science.gov (United States)

    Lou, Hans C

    2012-02-01

    Self-awareness is a pivotal component of any conscious experience and conscious self-regulation of behaviour. A paralimbic network is active, specific and causal in self-awareness. Its regions interact by gamma synchrony. Gamma synchrony develops throughout infancy, childhood and adolescence into adulthood and is regulated by dopamine and other neurotransmitters via GABA interneurons. Major derailments of this network and self-awareness occur in developmental disorders of conscious self-regulation like autism, attention deficit hyperactivity disorder (ADHD) and schizophrenia. Recent research on conscious experience is no longer limited to the study of neural 'correlations' but is increasingly lending itself to the study of causality. This paradigm shift opens new perspectives for understanding the neural mechanisms of the developing self and the causal effects of their disturbance in developmental disorders. © 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica.

  3. [Psychological research on the cognitive aspect of emotional processes in schizophrenia patients].

    Science.gov (United States)

    Kurek, N S

    1988-01-01

    Cognitive aspects of emotionality were psychologically investigated in 250 patients with continuous and paroxysmal progredient schizophrenia and differently pronounced defect. The control group consisted of 100 normal subjects. A set of 7 techniques was applied. In cases of the patient's defect accentuated, cognitive emotional disorder was marked with the emotions and emotiogenic situations underestimation in dealing with other people and cognitive activities. This underestimation was not a uniform one concerning to a larger extent the strong emotions in other subjects, patients' own positive emotions, success in individual problem solving and degree of success in cooperative performance. Weak emotions, negative ones and failure situations were underestimated to a lesser degree, as was the success rating in competitive paradigms.

  4. Long-term maternal recall of obstetric complications in schizophrenia research.

    Science.gov (United States)

    Walshe, Muriel; McDonald, Colm; Boydell, Jane; Zhao, Jing Hua; Kravariti, Eugenia; Touloupoulou, Timothea; Fearon, Paul; Bramon, Elvira; Murray, Robin M; Allin, Matthew

    2011-05-30

    Obstetric complications (OCs) are consistently implicated in the aetiology of schizophrenia. Information about OCs is often gathered retrospectively, from maternal interview. It has been suggested that mothers of people with schizophrenia may not be accurate in their recollection of obstetric events. We assessed the validity of long term maternal recall by comparing maternal ratings of OCs with those obtained from medical records in a sample of mothers of offspring affected and unaffected with psychotic illness. Obstetric records were retrieved for 30 subjects affected with psychosis and 40 of their unaffected relatives. The Lewis-Murray scale of OCs was completed by maternal interview for each subject blind to the obstetric records. There was substantial agreement between maternal recall and birth records for the summary score of "definite" OCs, birth weight, and most of the individual items rated, with the exception of antepartum haemorrhage. There were no significant differences in the validity of recall or in errors of commission by mothers for affected and unaffected offspring. These findings indicate that several complications of pregnancy and delivery are accurately recalled by mother's decades after they occurred. Furthermore, there is no indication that mothers are less accurate in recalling OCs for their affected offspring than their unaffected offspring. When comparing women with and without recall errors, we found those with recall errors to have significantly worse verbal memory than women without such errors. Assessing the cognition of participants in retrospective studies may allow future studies to increase the reliability of their data. Copyright © 2011 Elsevier Ltd. All rights reserved.

  5. Rethinking schizophrenia.

    Science.gov (United States)

    Insel, Thomas R

    2010-11-11

    How will we view schizophrenia in 2030? Schizophrenia today is a chronic, frequently disabling mental disorder that affects about one per cent of the world's population. After a century of studying schizophrenia, the cause of the disorder remains unknown. Treatments, especially pharmacological treatments, have been in wide use for nearly half a century, yet there is little evidence that these treatments have substantially improved outcomes for most people with schizophrenia. These current unsatisfactory outcomes may change as we approach schizophrenia as a neurodevelopmental disorder with psychosis as a late, potentially preventable stage of the illness. This 'rethinking' of schizophrenia as a neurodevelopmental disorder, which is profoundly different from the way we have seen this illness for the past century, yields new hope for prevention and cure over the next two decades.

  6. Water Finance Webinars and Forums

    Science.gov (United States)

    The Center hosts a series of water finance forums. These forums bring together communities with drinking water, wastewater, and stormwater project financing needs in an interactive peer-to-peer networking format.

  7. The Behavior of Hydrogen Under Extreme Conditions on Ultrafast Timescales (A 'Life at the Frontiers of Energy Research' contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

    International Nuclear Information System (INIS)

    Mao, Ho-kwang

    2011-01-01

    'The Behavior of Hydrogen Under Extreme Conditions on Ultrafast Timescales ' was submitted by the Center for Energy Frontier Research in Extreme Environments (EFree) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. EFree is directed by Ho-kwang Mao at the Carnegie Institute of Washington and is a partnership of scientists from thirteen institutions.The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges. The mission of Energy Frontier Research in Extreme Environments is 'to accelerate the discovery and creation of energy-relevant materials using extreme pressures and temperatures.' Research topics are: catalysis (CO 2 , water), photocatalysis, solid state lighting, optics, thermelectric, phonons, thermal conductivity, solar electrodes, fuel cells, superconductivity, extreme environment, radiation effects, defects, spin dynamics, CO 2 (capture, convert, store), greenhouse gas, hydrogen (fuel, storage), ultrafast physics, novel materials synthesis, and defect tolerant materials.

  8. Diversity or disarray? A systematic review of decision-making capacity for treatment and research in schizophrenia and other non-affective psychoses.

    Science.gov (United States)

    Spencer, B W J; Shields, G; Gergel, T; Hotopf, M; Owen, G S

    2017-08-01

    Valid consent for treatment or research participation requires that an individual has decision-making capacity (DMC), which is the ability to make a specific decision. There is evidence that the psychopathology of schizophrenia can compromise DMC. The objective of this review was to examine the presence or absence of DMC in schizophrenia and the socio-demographic/psychopathological factors associated. We searched three databases Embase, Ovid MEDLINE(R), and PsycINFO for studies reporting data on the proportion of DMC for treatment and research (DMC-T and DMC-R), and/or socio-demographic/psychopathological associations with ability to make such decisions, in people with schizophrenia and related illnesses. A total of 40 studies were identified. While high levels of heterogeneity limited direct comparison, meta-analysis of inpatient data showed that DMC-T was present in 48% of people. Insight was strongly associated with DMC-T. Neurocognitive deficits were strongly associated with lack of DMC-R and to a lesser extent DMC-T. With the exception of years of education, there was no evidence for an association with socio-demographic factors. Insight and neurocognitive deficits are most closely associated with DMC in schizophrenia. The lack of an association with socio-demographic factors dispels common misperceptions regarding DMC and characteristics such as age. Although our results reveal a wide spectrum of DMC-T and DMC-R in schizophrenia, this could be partly due to the complexity of the DMC construct and the heterogeneity of existing studies. To facilitate systematic review research, there is a need for improvement within research study design and increased consistency of concepts and tools.

  9. Science Translational Medicine – improving human health care worldwide by providing an interdisciplinary forum for idea exchange between basic scientists and clinical research practitioners

    Directory of Open Access Journals (Sweden)

    Forsythe, Katherine

    2010-09-01

    Full Text Available Science Translational Medicine’s mission is to improve human health care worldwide by providing a forum for communication and interdisciplinary idea exchange between basic scientists and clinical research practitioners from all relevant established and emerging disciplines. The weekly journal debuted in October 2009 and is published by the American Association for the Advancement of Science (AAAS, the publisher of Science and Science Signaling. The journal features peer-reviewed research articles, perspectives and commentary, and is guided by an international Advisory Board, led by Chief Scientific Adviser, Elias A. Zerhouni, M.D., former Director of the National Institutes of Health, and Senior Scientific Adviser, Elazer R. Edelman, M.D., Ph.D., Thomas D. and Virginia W. Cabot Professor of Health Sciences and Technology, Massachusetts Institute of Technology. The Science Translational Medicine editorial team is led by Katrina L. Kelner, Ph.D., AAAS. A profound transition is required for the science of translational medicine. Despite 50 years of advances in our fundamental understanding of human biology and the emergence of powerful new technologies, the rapid transformation of this knowledge into effective health measures is not keeping pace with the challenges of global health care. Creative experimental approaches, novel technologies, and new ways of conducting scientific explorations at the interface of established and emerging disciplines are now required to an unprecedented degree if real progress is to be made. To aid in this reinvention, Science and AAAS have created a new interdisciplinary journal, Science Translational Medicine. The following interview exemplefies the pioneering content found in Science Translational Medicine. It is an excerpt from a Podcast interview with Dr. Samuel Broder, former director of the National Cancer Institute and current Chief Medical Officer at Celera. The Podcast was produced in tangent with Dr

  10. THE ENVIRONMENTAL COMMUNICATION FORUM

    African Journals Online (AJOL)

    could enable the more effective communication of envi:onmental issues, not forgetting the importance ... headquarters, when she explained the psychology used to try to persuade people to care for their environ- ment. ... offering a facility if those to whom it is offered are unaware of its existence, or of its value. This the forum ...

  11. 2012 National Leadership Forum

    Science.gov (United States)

    Magnuson, Peter

    2012-01-01

    Two key themes emerged from the 2012 National Leadership Forum: Taking Business to School, which was hosted by the Career and Technical Education Foundation at the end of May. The first was that employers are looking for a workforce that is technologically savvy while having leadership and employability skills. The second is that the business…

  12. Prefrontal cortical gamma-aminobutyric acid transmission and cognitive function: drawing links to schizophrenia from preclinical research.

    Science.gov (United States)

    Tse, Maric T; Piantadosi, Patrick T; Floresco, Stan B

    2015-06-01

    Cognitive dysfunction in schizophrenia is one of the most pervasive and debilitating aspects of the disorder. Among the numerous neural abnormalities that may contribute to schizophrenia symptoms, perturbations in markers for the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), particularly within the frontal lobes, are some of the most reliable alterations observed at postmortem examination. However, how prefrontal GABA dysfunction contributes to cognitive impairment in schizophrenia remains unclear. We provide an overview of postmortem GABAergic perturbations in the brain affected by schizophrenia and describe circumstantial evidence linking these alterations to cognitive dysfunction. In addition, we conduct a survey of studies using neurodevelopmental, genetic, and pharmacologic rodent models that induce schizophrenia-like cognitive impairments, highlighting the convergence of these mechanistically distinct approaches to prefrontal GABAergic disruption. We review preclinical studies that have directly targeted prefrontal cortical GABAergic transmission using local application of GABAA receptor antagonists. These studies have provided an important link between GABA transmission and cognitive dysfunction in schizophrenia because they show that reducing prefrontal inhibitory transmission induces various cognitive, emotional, and dopaminergic abnormalities that resemble aspects of the disorder. These converging clinical and preclinical findings provide strong support for the idea that perturbations in GABA signaling drive certain forms of cognitive dysfunction in schizophrenia. Future studies using this approach will yield information to refine further a putative "GABA hypothesis" of schizophrenia. Copyright © 2015 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

  13. Drug-induced psychosis: how to avoid star gazing in schizophrenia research by looking at more obvious sources of light

    Directory of Open Access Journals (Sweden)

    Alessandra Paparelli

    2011-01-01

    Full Text Available The prevalent view today is that schizophrenia is a syndrome rather than a specific disease. Liability to schizophrenia is highly heritable. It appears that multiple genetic and environmental factors operate together to push individuals over a threshold into expressing the characteristic clinical picture. One environmental factor which has been curiously neglected is the evidence that certain drugs can induce schizophrenia-like psychosis. In the last 60 years, improved understanding of the relationship between drug abuse and psychosis has contributed substantially to our modern view of the disorder suggesting that liability to psychosis in general, and to schizophrenia in particular, is distributed trough the general population in a similar continuous way to liability to medical disorders such as hypertension and diabetes. In this review we examine the main hypotheses resulting from the link observed between the most common psychomimetic drugs (LSD, amphetamines, cannabis, PCP and schizophrenia.

  14. Human endogenous retrovirus type W (HERV-W) in schizophrenia: a new avenue of research at the gene-environment interface.

    Science.gov (United States)

    Leboyer, Marion; Tamouza, Ryad; Charron, Dominique; Faucard, Raphaél; Perron, Hervé

    2013-03-01

    Provide a synthetic review of recent studies evidencing an association between human endogenous retrovirus-W (HERV-W) and schizophrenia. Bibliography analysis and contextual synthesis. Epidemiological studies suggest that the aetiology of schizophrenia is complex and involves a complex interplay of genetic and environmental factors such as infections. Eight percentof the human genome consists of human endogenous retroviruses (HERV), and this part of the genome was previously thought to be without importance, but new research has refuted this. HERVs share similarities with viruses and it is assumed that HERVs are present in the genome as a result of retroviruses infecting germ line cells many million years ago. A specific type of HERVs, called HERV-W, has through several recent studies been associated with schizophrenia. Elevated transcription of HERV-W elements has been documented, and antigens of HERV-W envelope and capsid proteins have been found in blood samples from patients. Viruses that have been implicated in pathology of schizophrenia, such as herpes and influenza, have been shown to activate HERV-W elements, and such activation has been associated with elevated biomarkers of systemic inflammation. New research indicates that HERV-W may be an important genetic factor interplaying with the environmental risk factor of infections and that, through this, HERV-W may be important for disease pathogenesis. A lifelong scenario of a detrimental interaction between infectious agents and HERV-W genes may decipher the actual development and course of schizophrenia. Further research is needed to find out if specific treatment strategies could reduce the expression of HERV-W and if this will be associated with remission.

  15. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Photo 01: Members of the Forum Engelberg and public figures from Geneva visit SM18, the test hall for LHC magnets: (left to right) N. Siegel, Prof. Dr. Med. Bernard Mach, Mr Alexander Höchli, H. Wenninger, Mrs Mireille Quirina, Mme Konrade Von Bremen, Mrs Thérèse Wolf, Prof. Roger Berthouzoz, Mrs Marie-Anne Heimo, Mr Bernard Ecoffey.

  16. The neuroproteomics of schizophrenia.

    LENUS (Irish Health Repository)

    English, Jane A

    2011-01-15

    Proteomics is the study of global gene expression of an organ, body system, fluid, or cellular compartment at the protein level. Proteomic findings are reflective of complex gene × environment interactions, and the importance of this is increasingly appreciated in schizophrenia research. In this review, we outline the main proteomic methods available to researchers in this area and summarize, for the first time, the findings of the main quantitative neuroproteomic investigations of schizophrenia brain. Our review of these data revealed 16 gray matter proteins, and eight white matter proteins that were differentially expressed in the same direction in two or more investigations. Pathway analysis identified cellular assembly and organization as particularly disrupted in both gray and white matter, whereas the glycolysis-gluconeogenesis pathway was the major signaling pathway significantly altered in both. Reassuringly, these findings show remarkable convergence with functional pathways and positional candidate genes implicated from genomic studies. The specificity of schizophrenia proteomic findings are also addressed in the context of neuroproteomic investigations of neurodegenerative disorders and bipolar disorder. Finally, we discuss the major challenges in the field of neuroproteomics, such as the need for high throughput validation methods and optimal sample preparation. Future directions in the neuroproteomics of schizophrenia, including the use of blood-based biomarker work, the need to focus on subproteomes, and the increasing use of mass spectrometry-based methods are all discussed. This area of research is still in its infancy and offers huge potential to our understanding of schizophrenia on a cellular level.

  17. Radiation protection forum

    International Nuclear Information System (INIS)

    Cabral, W.

    2010-01-01

    The National Director of the Nuclear Regulatory Authority and Radiation Protection of Uruguay in the first forum for radiation protection set out the following themes: activity of regulatory body, radiation safety, physical security, safeguards, legal framework, committed substantive program, use of radiation, risks and benefits, major sources of radiation, the national regulatory framework, national inventory of sources, inspections, licensing, import and export of sources control , radioactive transport, materials safety, agreements, information and teaching, radiological emergencies and prompt response.

  18. Young physicists' forum

    International Nuclear Information System (INIS)

    Adams, T.

    2001-01-01

    The Young Physicists' Forum was an opportunity for the younger members of the particle-physics community to gather at Snowmass 2001 and to study and debate major issues that face the field over the next twenty years. Discussions were organized around three major topics: outreach and education, the impact of globalization, and building a robust and balanced field. We report on the results of these discussions, as presented on July 17, 2001

  19. Variations in the Incidence of Schizophrenia: Data Versus Dogma

    Science.gov (United States)

    McGrath, John J

    2006-01-01

    The schizophrenia research community has shared a belief that the incidence of schizophrenia shows little variation. This belief is related to the dogma that schizophrenia affects all individuals equally, regardless of sex, race, or nationality. However, there is now robust evidence that the incidence of schizophrenia is characterized by substantial variability. There is prominent variation in the incidence of schizophrenia between sites. The incidence of schizophrenia is significantly higher in males than in females (male:female ratio = 1.4). Migrants and those living in urban areas have a higher incidence of schizophrenia. The incidence of schizophrenia has fluctuations across time. In addition, the prevalence of schizophrenia is also characterized by prominent variation. The realization that schizophrenia is characterized by rich and informative gradients will serve as a catalyst for future research. PMID:16135560

  20. The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for GxE research.

    Science.gov (United States)

    Iyegbe, Conrad; Campbell, Desmond; Butler, Amy; Ajnakina, Olesya; Sham, Pak

    2014-02-01

    Schizophrenia is a devastating mental disorder. The level of risk in the general population is sustained by the persistence of social, environmental and biological factors, as well as their interactions. Socio-environmental risk factors for schizophrenia are well established and robust. The same can belatedly be said of genetic risk factors for the disorder. Recent progress in schizophrenia genetics is primarily fuelled by genome-wide association, which is able to leverage substantial proportions of additional explained variance previously classified as 'missing'. Here, we provide an outline of the emerging genetic landscape of schizophrenia and demonstrate how this knowledge can be turned into a simple empirical measure of genetic risk, known as a polygenic risk score. We highlight the statistical framework used to assess the clinical potential of the new score and finally, draw relevance to and discuss the clinical implications for the study of gene-environment interaction.

  1. Visual Analysis of MOOC Forums with iForum.

    Science.gov (United States)

    Fu, Siwei; Zhao, Jian; Cui, Weiwei; Qu, Huamin

    2017-01-01

    Discussion forums of Massive Open Online Courses (MOOC) provide great opportunities for students to interact with instructional staff as well as other students. Exploration of MOOC forum data can offer valuable insights for these staff to enhance the course and prepare the next release. However, it is challenging due to the large, complicated, and heterogeneous nature of relevant datasets, which contain multiple dynamically interacting objects such as users, posts, and threads, each one including multiple attributes. In this paper, we present a design study for developing an interactive visual analytics system, called iForum, that allows for effectively discovering and understanding temporal patterns in MOOC forums. The design study was conducted with three domain experts in an iterative manner over one year, including a MOOC instructor and two official teaching assistants. iForum offers a set of novel visualization designs for presenting the three interleaving aspects of MOOC forums (i.e., posts, users, and threads) at three different scales. To demonstrate the effectiveness and usefulness of iForum, we describe a case study involving field experts, in which they use iForum to investigate real MOOC forum data for a course on JAVA programming.

  2. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996. This series of photos was taken during a speech he made as part of a visit to CERN.

  3. Predicting risk and the emergence of schizophrenia.

    LENUS (Irish Health Repository)

    Clarke, Mary C

    2012-09-01

    This article gives an overview of genetic and environmental risk factors for schizophrenia. The presence of certain molecular, biological, and psychosocial factors at certain points in the life span, has been linked to later development of schizophrenia. All need to be considered in the context of schizophrenia as a lifelong brain disorder. Research interest in schizophrenia is shifting to late childhood\\/early adolescence for screening and preventative measures. This article discusses those environmental risk factors for schizophrenia for which there is the largest evidence base.

  4. Online self-help forums on cannabis: A content assessment.

    Science.gov (United States)

    Greiner, Christian; Chatton, Anne; Khazaal, Yasser

    2017-10-01

    To investigate online self-help forums related to cannabis users who were searching for help on the Internet. We analyzed the content of 717 postings by 328 users in three online forums in terms of fields of interest and self-help mechanisms. Only English-language forums that were free of charge and without registration were investigated. The main self-help mechanisms were disclosure and symptoms, with relatively few posts concerning legal issues and social perceptions. The forums differed significantly in all fields of interest and self-help mechanisms except for social network and financial and vocational issues. Highly involved users more commonly posted on topics related to diagnosis, etiology/research, and provision of information and less commonly on those related to gratitude. Correlation analysis showed a moderate negative correlation between emotional support and illness-related aspects and between emotional support and exchange of information. Cannabis forums share similarities with other mental health forums. Posts differ according to user involvement and the specific orientation of the forum. The Internet offers a viable source of self-help and social support for cannabis users, which has potential clinical implications in terms of referring clients to specific forums. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. [Prevention of schizophrenia: a review].

    Science.gov (United States)

    Balhara, Yatan Pal Singh

    2013-01-01

    Research over the years has introduced multiple interventions for schizophrenia. Notwithstanding the nature of intervention pharmacological or psychological a complete cure for the condition remains a much-desired, yet unachieved goal. What is required is an exploration of alternative intervention strategies for treating schizophrenia a preventive approach is such an option. The chronic nature of schizophrenia and its associated disabilities have a tremendously negative affect the quality of life of patients, their families, and communities. Among the preferred approaches to reducing the negative consequences associated with the disorder is the prevention of its emergence. This review aimed to present the available data on the prevention of schizophrenia data that suggest some pharmacological and non-pharmacological interventions have a potential role in the prevention of schizophrenia. Nonetheless, the findings are restricted to a few sites and are at best preliminary; as such, the findings must be replicated in new studies that include large samples and different settings.

  6. Childhood Schizophrenia

    Science.gov (United States)

    ... Trouble sleeping Irritability or depressed mood Lack of motivation Strange behavior Substance use Compared with schizophrenia symptoms ... may neglect personal hygiene or appear to lack emotion ― doesn't make eye contact, doesn't change ...

  7. NASA Earthdata Forums: An Interactive Venue for Discussions of NASA Data and Earth Science

    Science.gov (United States)

    Hearty, Thomas J., III; Acker, James; Meyer, Dave; Northup, Emily A.; Bagwell, Ross E.

    2017-01-01

    We demonstrate how students and teachers can register to use the NASA Earthdata Forums. The NASA Earthdata forums provide a venue where registered users can pose questions regarding NASA Earth science data in a moderated forum, and have their questions answered by data experts and scientific subject matter experts connected with NASA Earth science missions and projects. Since the forums are also available for research scientists to pose questions and discuss pertinent topics, the NASA Earthdata Forums provide a unique opportunity for students and teachers to gain insight from expert scientists and enhance their knowledge of the many different ways that NASA Earth observations can be used in research and applications.

  8. Self-Governance on Trial: A Public Sphere Analysis of News Website Forum Comments

    Directory of Open Access Journals (Sweden)

    J. David Wolfgang

    2016-04-01

    Full Text Available The online public sphere offers society an opportunity to pursue self-governance through rational-critical discourse of public issues. However, testing the effectiveness of the sphere involves studying the structure of the online forum (e.g. whether the forum allows for pseudonymous comments or not and the quality of the content in the forum. This research studied online news forums on the topics of gun control and civil unions in Colorado to see what barriers to participating in the forum might exist in the structure of the forum and then what types of content was produced in the forum. The research showed that a forum allowing commenters to use a pseudonym led to comments with more exchange and critique of reasoned normative positions and use of supporting facts. However, neither the pseudonymous forum nor the identified forum had stronger levels of commitment to constructive dialogue in the forum. Also, commenters showed no reflexivity in their comments, meaning that participants were not assessing their own positions or changing their perspectives based on the arguments of others. While this shows that reducing barriers to accessing the forum helps to produce a public sphere environment, there is still work to be done in improving the level of constructive dialogue and stimulating negotiation and consensus building.

  9. LLW Forum meeting report

    International Nuclear Information System (INIS)

    1991-01-01

    This document reports the details of the Quarterly Meeting of the Low- Level Radioactive Waste Forum held in San Diego, California during January 23-25, 1991. Topics discussed include: State and Compact Progress Reports; Legal Updates; Update on Technical Assistance; Advanced Notice of Proposed Rulemaking Regarding Surcharge Rebates; Update on TCC Activities; NRC Update; Disposal of Commercial Mixed Waste; Update on EPA Activities; ACNW Working Group on Mixed Waste; National Profile on Mixed Waste; Commercial Perspective on Mixed Waste; Update on DOT Activities; Source Terms; Materials and Waste; Storage: and Waste Acceptance Criteria and Packaging

  10. Neural complexity, dissociation, and schizophrenia

    Czech Academy of Sciences Publication Activity Database

    Bob, P.; Šusta, M.; Chládek, Jan; Glaslová, K.; Fedor-Ferybergh, P.

    2007-01-01

    Roč. 13, č. 10 (2007), HY1-5 ISSN 1234-1010 Institutional research plan: CEZ:AV0Z20650511 Keywords : neural complexity * dissociation * schizophrenia Subject RIV: FH - Neurology Impact factor: 1.607, year: 2007

  11. Neural chaos and schizophrenia

    Czech Academy of Sciences Publication Activity Database

    Bob, P.; Chládek, Jan; Šusta, M.; Glaslová, K.; Jagla, F.; Kukleta, M.

    2007-01-01

    Roč. 26, č. 4 (2007), s. 298-305 ISSN 0231-5882 Institutional research plan: CEZ:AV0Z20650511 Keywords : EDA * Lyapunov exponent * schizophrenia * chaos Subject RIV: FL - Psychiatry, Sexuology Impact factor: 1.286, year: 2007

  12. Forum-ing: Signature practice for public theological discourse ...

    African Journals Online (AJOL)

    The forum meets every Monday morning, except when there is a national holiday. It has operated 30 consecutive years. The forum has a series of presentations, including the opening prayer, self-introductions of each person, a report of the executive director, special presentations from selected community groups, reports, ...

  13. Nuclear systems of the future: international forum generation 4 and research and development projects at the Cea; Systemes nucleaires du futur: forum international generation 4 et projets de R et D du CEA

    Energy Technology Data Exchange (ETDEWEB)

    Carre, F

    2003-07-01

    To advance nuclear energy to meet future energy needs, ten countries have agreed to develop a future generation of nuclear energy systems, known as Generation 4. A technology road map to guide the Generation 4 effort was begun. This document presents the goals for these nuclear systems and the research programs of the Cea on the gas technology, GT-MHR, VHTR and GFR and the other systems as sodium Fast Neutron reactors, supercritical water and space nuclear. (A.L.B.)

  14. Developers@CERN Forums: Python

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    The Developers@CERN Forums second edition took place at the end of May on the topic of Python. How do developers at CERN interact with Python? Which cutting-edge projects are using Python? What were the highlights of this most recent forum?

  15. London International Youth Science Forum

    Science.gov (United States)

    Auty, Geoff

    2010-01-01

    In this article, the author discusses the 2010 London International Youth Science Forum (LIYSF) and shares his experience in attending the forum. Unlike the Harry Messel event in Sydney, which takes place every two years, LIYSF is an annual event. Before moving to Imperial College London, LIYSF was held at the Institute of Electrical Engineers and…

  16. Neurodevelopment, GABA System Dysfunction, and Schizophrenia

    OpenAIRE

    Schmidt, Martin J; Mirnics, Karoly

    2014-01-01

    The origins of schizophrenia have eluded clinicians and researchers since Kraepelin and Bleuler began documenting their findings. However, large clinical research efforts in recent decades have identified numerous genetic and environmental risk factors for schizophrenia. The combined data strongly support the neurodevelopmental hypothesis of schizophrenia and underscore the importance of the common converging effects of diverse insults. In this review, we discuss the evidence that genetic and...

  17. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President, Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996 - is pictured here. Photo 01: Hubert Curien in front of the first half of the CMS detector's barrel hadronic calorimeter (HCAL). The barrel HCAL is a cylindrical structure which will surround the collision region and measure the energy of quarks and jets emerging at large angles relative to the beam direction. Photo 02: Hubert Curien (left) with Bernard Ecoffey, Founder of the Forum Engelberg, in front of the first half of the CMS detector's barrel hadronic calorimeter.

  18. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996. He is pictured here (centre) with (left to right) Raymond Battistella, Director-General of SIG, Geneva's utilities provider; Michel Della Negra; Marie-Anne Heimo; Jean-Claude Landry; and Bernard Ecoffey, Founder of the Forum Engelberg, in front of the CMS detector under construction. Visible are three of the five concentric rings forming the barrel yoke which returns the magnetic flux generated by the superconducting coil.

  19. The International Technical Safety Forum

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    The International Technical Safety Forum is a meeting of safety experts from several physics labs in Europe and the US. Since 1998 participants have been meeting every couple of years to discuss common challenges in safety matters. The Forum helps them define best practices and learn from the important lessons learned by others.   The Forum's participants in front of building 40. This year, the meeting took place at CERN from 12 to 16 April. “This year's meeting covered subjects ranging from communication and training in matters of safety, to cryogenic safety, emergency preparedness and risk analysis”, explains Ralf Trant, head of the CERN Safety Commission and organiser of this year’s Forum. Radiation protection issues are not discussed at the meeting since they involve different expertise. The goal of the Forum is to allow participants to share experience, learn lessons and acquire specific knowledge in a very open way. Round-table discussions, dedicated time for ...

  20. STAIF96: space technology and applications international forum. Proceedings

    International Nuclear Information System (INIS)

    El-Genk, M.S.

    1996-01-01

    These proceedings represent papers presented at the Space Technology and Applications International Forum-STAIF. STAIF-96 hosted four technical conferences sharing the common interest in space exploration, technology, and commercialization. Topics discussed include space station, space transportation, materials processing in space, commercial forum, space power, commercial space ports, microelectronics, automation of robotics-space application, remote sensing, small business innovative research and communications. There were 243 papers presented at the forum, and 138 have been abstracted for the Energy Science and Technology database. STAIF-96 was partly sponsored by the U.S. Department of Energy

  1. Analysis of Superposters' Motives for Participating in Online Forum Discussions

    Directory of Open Access Journals (Sweden)

    Irena Miljković Krečar

    2017-12-01

    Full Text Available The main aim of this study was to identify factors which motivate daily participation of extremely active online forum members. An extensive online questionnaire was constructed and sent to the Forum.hr members with more than 8,000 posts. The final sample consisted of 112 respondents. Principal components analysis provided an interpretable three components solution, explaining 54.6% of the item variance. The components were labelled as self-esteem, information exchange, and confrontation. Some significant differences were also found among motivational subscales and variables of gender, age, and the intensity of forum activity. Results are discussed in relation to previous research.

  2. Forum Engelberg, 1-4 March 2004

    CERN Document Server

    2004-01-01

    The 2004 Forum Engelberg will pay tribute to its President, Hubert Curien, a former President of the CERN Council and former French Minister for Research. The subject of this year's conference, which will take place in Lucerne from 1st to 4th March 2004, is "Science on the Agenda of European Politics." This year, there will be talks by numerous speakers, including the directors of the seven European intergovernmental scientific organisations (EIROforum) and the European Commissioner for Research, Philippe Busquin. The highlights of the conference will include an Interdisciplinary Scientific Programme on 2nd and 3rd March, a session on e-science and the Grid on 4th March and a Young Scientists Programme. The programme and registration forms are available at http://www.forum-engelberg.org/

  3. Hippocampus and amygdala volumes in children and young adults at high-risk of schizophrenia: research synthesis.

    Science.gov (United States)

    Ganzola, Rossana; Maziade, Michel; Duchesne, Simon

    2014-06-01

    Studies have reported hippocampal and amygdala volume abnormalities in schizophrenic patients. It is necessary to explore the potential for these structures as early disease markers in subjects at high risk (HR) of schizophrenia. We performed a review of 29 magnetic resonance imaging (MRI) studies measuring hippocampal and amygdala volumes in subjects at HR for schizophrenia. We reclassified subjects in 3 new HR categories: presence of only risk symptoms (psychotic moderate symptoms), presence of only risk factors (genetic, developmental or environmental), and presence of combined risk symptoms/factors. Hippocampal volume reductions were detected in subjects with first episode (FE) of psychosis, in all young adults and in adolescents at HR of schizophrenia. The loss of tissue was mainly located in the posterior part of hippocampus and the right side seems more vulnerable in young adults with only risk symptoms. Instead, the anterior sector seems more involved in HR subjects with genetic risks. Abnormal amygdala volumes were found in FE subjects, in children with combined risk symptoms/factors and in older subjects using different inclusion criteria, but not in young adults. Hippocampal and amygdala abnormalities may be present before schizophrenia onset. Further studies should be conducted to clarify whether these abnormalities are causally or effectually related to neurodevelopment. Shape analysis could clarify the impact of environmental, genetic, and developmental factors on the medial temporal structures during the evolution of this disease. Copyright © 2014 Elsevier B.V. All rights reserved.

  4. Internet delivered question and answer column for patients with schizophrenia.

    Science.gov (United States)

    Maijala, Riikka; Anttila, Minna; Koivunen, Marita; Pitkänen, Anneli; Kuosmanen, Lauri; Välimäki, Maritta

    2015-01-01

    The purpose of this study was to describe the use of an Internet delivered question and answer column among patients with schizophrenia. The column was developed for research purposes. The study sample consisted of patients (N = 100) admitted to acute inpatient psychiatric care in two hospital districts. Descriptive data were collected from the column to which a nurse replied within 3 days and analysed using qualitative content analysis. The column had four to five questions weekly. The most common age of users was 18-24 years, and the gender distribution was almost equal. Column use was heaviest among students (44%) and least among unemployed people (19%). Out of 85 questions or comments sent to the column, 25 (29%) were related to program training and the remaining 60 (71%) were related to medication (31%), illness and tests (25%), other questions or comments (9%), daily life and coping with it (4%), and places to receive treatment (2%). An Internet delivered question and answer column can be included in the care of patients with schizophrenia. However, it requires a new type of basic and additional education in the field of mental health care in order for nurses to be able to provide nursing via the Internet forum.

  5. Mutated Genes in Schizophrenia Map to Brain Networks

    Science.gov (United States)

    ... Matters NIH Research Matters August 12, 2013 Mutated Genes in Schizophrenia Map to Brain Networks Schizophrenia networks ... have a high number of spontaneous mutations in genes that form a network in the front region ...

  6. Hyperglycemia and diabetes in patients with schizophrenia or schizoaffective disorders

    NARCIS (Netherlands)

    Cohen, D; Stolk, RP; Grobbee, DE; Gispen-De Wied, CC

    OBJECTIVE - Pharmacoepidemiological studies have shown an increased prevalence of diabetes in patients with schizophrenia. To address this issue, we decided to assess glucose metabolism in a population of patients With schizophrenia or schizoaffective disorder. RESEARCH DESIGN AND METHODS - Oral

  7. Neurodevelopment, GABA System Dysfunction, and Schizophrenia

    Science.gov (United States)

    Schmidt, Martin J; Mirnics, Karoly

    2015-01-01

    The origins of schizophrenia have eluded clinicians and researchers since Kraepelin and Bleuler began documenting their findings. However, large clinical research efforts in recent decades have identified numerous genetic and environmental risk factors for schizophrenia. The combined data strongly support the neurodevelopmental hypothesis of schizophrenia and underscore the importance of the common converging effects of diverse insults. In this review, we discuss the evidence that genetic and environmental risk factors that predispose to schizophrenia disrupt the development and normal functioning of the GABAergic system. PMID:24759129

  8. Neurodevelopment, GABA system dysfunction, and schizophrenia.

    Science.gov (United States)

    Schmidt, Martin J; Mirnics, Karoly

    2015-01-01

    The origins of schizophrenia have eluded clinicians and researchers since Kraepelin and Bleuler began documenting their findings. However, large clinical research efforts in recent decades have identified numerous genetic and environmental risk factors for schizophrenia. The combined data strongly support the neurodevelopmental hypothesis of schizophrenia and underscore the importance of the common converging effects of diverse insults. In this review, we discuss the evidence that genetic and environmental risk factors that predispose to schizophrenia disrupt the development and normal functioning of the GABAergic system.

  9. Schizophrenia: Hope on the Horizon

    OpenAIRE

    Sullivan, Patrick F.

    2015-01-01

    Editor?s Note: In July 2014, an international consortium of schizophrenia researchers co-founded by the author mounted the largest biological experiment in the history of psychiatry and found eighty new regions in the genome associated with the illness. With many more avenues for exploring the biological underpinnings of schizophrenia now available to neuroscientists, hope may be on the way for the estimated 2.4 million Americans and 1 in 100 people worldwide affected by the illness, one in w...

  10. Can anonymous posters on medical forums be reidentified?

    Science.gov (United States)

    Bobicev, Victoria; Sokolova, Marina; El Emam, Khaled; Jafer, Yasser; Dewar, Brian; Jonker, Elizabeth; Matwin, Stan

    2013-10-03

    Participants in medical forums often reveal personal health information about themselves in their online postings. To feel comfortable revealing sensitive personal health information, some participants may hide their identity by posting anonymously. They can do this by using fake identities, nicknames, or pseudonyms that cannot readily be traced back to them. However, individual writing styles have unique features and it may be possible to determine the true identity of an anonymous user through author attribution analysis. Although there has been previous work on the authorship attribution problem, there has been a dearth of research on automated authorship attribution on medical forums. The focus of the paper is to demonstrate that character-based author attribution works better than word-based methods in medical forums. The goal was to build a system that accurately attributes authorship of messages posted on medical forums. The Authorship Attributor system uses text analysis techniques to crawl medical forums and automatically correlate messages written by the same authors. Authorship Attributor processes unstructured texts regardless of the document type, context, and content. The messages were labeled by nicknames of the forum participants. We evaluated the system's performance through its accuracy on 6000 messages gathered from 2 medical forums on an in vitro fertilization (IVF) support website. Given 2 lists of candidate authors (30 and 50 candidates, respectively), we obtained an F score accuracy in detecting authors of 75% to 80% on messages containing 100 to 150 words on average, and 97.9% on longer messages containing at least 300 words. Authorship can be successfully detected in short free-form messages posted on medical forums. This raises a concern about the meaningfulness of anonymous posting on such medical forums. Authorship attribution tools can be used to warn consumers wishing to post anonymously about the likelihood of their identity being

  11. [Schizophrenia, environment and epigenetics].

    Science.gov (United States)

    Must, Anita; Janka, Zoltan; Horvath, Szatmar

    2011-12-01

    Psychotic, cognitive and affective symptoms defining schizophrenia may, though much less severe, manifest themselves in up to 10 to 20% of the general population. What explains the fact that in certain cases the symptoms require even constant medical supervision, while others are capable of living a normal life within social conventions? Which factors lead to the transition of mild, subclinical manifestations and vulnerability indicators towards the outburst of one of the most severe and depriving mental disorders? Genetic susceptibility is undoubtedly crucial. More recent research findings emphasize the modifying effect of specific environmental factors on gene expression. The gene-environment interplay may induce so-called epigenetic alterations which may manifest themselves over several generations. Future integrative, multi-dimensional and flexible schizophrenia research approaches focusing on the identification of neurobiological and cognitive outcomes are much needed to understand disease vulnerability, susceptibility mechanisms, periods and interactions. Research methods may differ, but our aim is common - establishing more effective diagnostic and therapeutic interventions.

  12. Genetics Home Reference: schizophrenia

    Science.gov (United States)

    ... Share: Email Facebook Twitter Home Health Conditions Schizophrenia Schizophrenia Printable PDF Open All Close All Enable Javascript to view the expand/collapse boxes. Description Schizophrenia is a brain disorder classified as a psychosis, ...

  13. Excess Early Mortality in Schizophrenia

    DEFF Research Database (Denmark)

    Laursen, Thomas Munk; Nordentoft, Merete; Mortensen, Preben Bo

    2014-01-01

    Schizophrenia is often referred to as one of the most severe mental disorders, primarily because of the very high mortality rates of those with the disorder. This article reviews the literature on excess early mortality in persons with schizophrenia and suggests reasons for the high mortality...... as well as possible ways to reduce it. Persons with schizophrenia have an exceptionally short life expectancy. High mortality is found in all age groups, resulting in a life expectancy of approximately 20 years below that of the general population. Evidence suggests that persons with schizophrenia may...... not have seen the same improvement in life expectancy as the general population during the past decades. Thus, the mortality gap not only persists but may actually have increased. The most urgent research agenda concerns primary candidates for modifiable risk factors contributing to this excess mortality...

  14. Forum on specification and Design Languages

    CERN Document Server

    Maehne, Torsten

    2015-01-01

    This book brings together a selection of the best papers from the sixteenth edition of the Forum on specification and Design Languages Conference (FDL), which was held in September 2013 in Paris, France. FDL is a well-established international forum devoted to dissemination of research results, practical experiences and new ideas in the application of specification, design and verification languages to the design, modeling and verification of integrated circuits, complex hardware/software embedded systems, and mixed-technology systems. • Covers applications of formal methods for specification, verification and debug; • Includes embedded analog and mixed-signal system design; • Enables model-driven engineering for embedded systems design and development.

  15. ECNS '99 - Young scientists forum

    DEFF Research Database (Denmark)

    Ceretti, M.; Janssen, S.; McMorrow, D.F.

    2000-01-01

    The Young Scientists Forum is a new venture for ECNS and follows the established tradition of an active participation by young scientists in these conferences. At ECNS '99 the Young Scientists Forum brought together 30 young scientists from 13 European countries. In four working groups, they disc......The Young Scientists Forum is a new venture for ECNS and follows the established tradition of an active participation by young scientists in these conferences. At ECNS '99 the Young Scientists Forum brought together 30 young scientists from 13 European countries. In four working groups......, they discussed emerging scientific trends in their areas of expertise and the instrumentation required to meet the scientific challenges. The outcome was presented in the Young Scientists Panel on the final day of ECNS '99. This paper is a summary of the four working group reports prepared by the Group Conveners...

  16. Forum on orthophotography: Summary Report

    Science.gov (United States)

    ,

    1990-01-01

    A Forum on Orthophotography was held on May 15, 1990, at the National Aeronautics and Space Administration's Goddard Space Flight Center in Greenbelt, Maryland. The forum was sponsored jointly by the U.S. Soil Conservation Service, the U.S. Geological Survey, the National Governors' Association, and the National Association of Counties. The purpose of the forum was to expand the understanding and use of orthophoto products among the user community, as well as among those currently considering, or as yet unfamiliar with, the use of these products. It was also intended to provide a forum for assessing requirements for, and interest in, orthophoto products and for the identification and discussion of issues and future needs concerning orthophoto use and coordination. The 1-day forum was organized into three major sessions that focussed on technical aspects, user applications, and management issues. The first session presented a brief background and overview of the technical characteristics of standard and digital orthophotos. The second session included formal presentations by Federal, State, and county government agencies on their current and planned applications of orthophoto products, with particular emphasis on their use within geographic information systems. In the third session, private industry addressed their community's interest, capabilities, and potential role. This session also included a proposal by the U.S. Soil Conservation Service for a national cooperative program for the production of l:12,000-scale orthophotoquad products. In addition to the formal presentations, the forum provided a time for open discussion in which attendees had an opportunity to exchange information and make statements about their needs or other items pertinent to the production and dissemination of orthophoto products. Several agency orthophoto product exhibits and interactive demonstrations were also available throughout the day. This report includes a forum agenda and

  17. Fagligt Forum ved en skillevej

    DEFF Research Database (Denmark)

    Bjerg, Claus

    2008-01-01

    Med cvu-bibliotekernes overgang til professionshøjskoler ændres det biblioteksfaglige landskab. Det har Fagligt Forum taget konsekvensen af og nedlægger sig selv i løbet af 2000......Med cvu-bibliotekernes overgang til professionshøjskoler ændres det biblioteksfaglige landskab. Det har Fagligt Forum taget konsekvensen af og nedlægger sig selv i løbet af 2000...

  18. Forum, Dedicated to Inclusive Education

    Directory of Open Access Journals (Sweden)

    Vachkov I.V.

    2015-06-01

    Full Text Available 26 – 27 of February 2015 in Kazan, in the University of Management “TISBI” been held National (All-Russian forum of promotion of ideas and principles of inclusive education (with international participants “Study and live together: open space of inclusion”. During the work of Forum the most topical questions of inclusive education implement in Russian Federation been discussed.

  19. Oxytocin model of formation of psychotic symptoms and its implications for research on oxytocinergic pathway in schizophrenia

    OpenAIRE

    Holka-Pokorska, Justyna; Jarema, Marek

    2014-01-01

    There are more and more data to support the dysregulation of the oxytocinergic pathway in schizophrenia. The development of the above branch of knowledge began to evolve alongside the mainstream of studies concerning gene polymorphisms for dopaminergic, glutamatergic and serotoninergic systems. Both experimental studies and clinical trials have demonstrated an antipsychotic effect of oxytocin. Starting with the pioneering neuroendocrinobehavioral experiment which demonstrated that oxytocin na...

  20. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996. Photo 01: Jean-Claude Landry, Department of the Interior, Agriculture and Environment, state of Geneva (right) in discussion with Peter Jenni, spokesperson for the ATLAS collaboration.

  1. Schizophrenia: A Systemic Disorder

    Science.gov (United States)

    Kirkpatrick, Brian; Miller, Brian; García-Rizo, Clemente; Fernandez-Egea, Emilio

    2015-01-01

    The concept of schizophrenia that is most widely taught is that it is a disorder in which psychotic symptoms are the main problem, and a dysregulation of dopamine signaling is the main feature of pathophysiology. However, this concept limits clinical assessment, the treatments offered to patients, research, and the development of therapeutics. A more appropriate conceptual model is that: 1) schizophrenia is not a psychotic disorder, but a disorder of essentially every brain function in which psychosis is present; 2) it is not a brain disease, but a disorder with impairments throughout the body; 3) for many patients, neuropsychiatric problems other than psychosis contribute more to impairment in function and quality of life than does psychosis; and, 4) some conditions that are considered to be comorbid are integral parts of the illness. In conclusion, students, patients, and family members should be taught this model, along with its implications for assessment, research, and therapeutics. PMID:23518782

  2. The International Research Training Group on "Brain-Behavior Relationship of Normal and Disturbed Emotions in Schizophrenia and Autism" as an Example of German-American Cooperation in Doctoral Training

    Science.gov (United States)

    Schneider, Frank; Gur, Ruben C.

    2008-01-01

    The International Research Training Group "Brain-Behavior Relationship of Normal and Disturbed Emotions in Schizophrenia and Autism" (IRTG 1328), funded by the German Research Council (DFG), is a German-American cooperation. Its major aims are interdisciplinary and international scientific cooperation and the support of young scientists…

  3. Prescribing patterns for inpatients with schizophrenia spectrum disorders in a psychiatric hospital in Slovenia: Results of 16-month prospective, non-interventional clinical research.

    Science.gov (United States)

    Bole, Cvetka Bačar; Pišlar, Mitja; Mrhar, Aleš; Tavčar, Rok

    2017-06-01

    In Slovenia, there has been no evidence about the prescribing patterns for inpatients with psychotic disorders. The research aims to analyze drug utilization patterns for inpatients with psychotic disorder that are coded as F20-F29 according to International Classification of Diseases (ICD) 10 th revision (schizophrenia spectrum disorders). Prospective research was conducted at the Psychiatric Hospital Idrija. The medical records of the inpatients admitted over a 12-month period were collected from the beginning to the end of their hospitalization. A total of 311 inpatients with 446 hospitalizations were included, producing a total of 3954 medication prescriptions. Medications prescribed pro re nata (the use of as needed) were also taken into account. Antipsychotics (N=1149, 43% of prescriptions) were the most often prescribed medications, followed by anxiolytics, antiparkinsonians, antidepressants, mood stabilizers and cardiovascular drugs. A total of 256 (82%) inpatients received at least one pro re nata medication. It was observed that the studied population was treated with one antipsychotic on 27 percent of prescriptions. Inpatients with schizophrenia spectrum disorders were exposed to a large number of different drugs. They were not received only psychotropic drugs but also other medications. With the knowledge about medications the implementation of clinical pharmacy services to the psychiatrists would significantly improve medication of inpatients with psychotic disorders and polypharmacotherapy.

  4. The green highway forum

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    In late 2004, as part of American Coal Ash Association's (ACAA) strategic planning process, a plan was approved by its Board of Directors implementing a 'green highways' concept which emphasized use of coal combustion products (CCPs) in highways in a variety of ways including being used alone, in combination with other forms of CCPs, and combined with non ash materials. The incentives behind the developed concept were the derived advantages from beneficial technical economic and environmental impacts. Although the primary use of fly ash is concrete, other forms of CCPs could be considered for more non-traditional highway applications. For example, these might include soils stabilization, binders for in-place pavement recycling, use in flowable fills, aggregates, source materials for structural fills and embankments, components in manufactured soils, and for granular base courses beneath pavements. At this same time, unknown to ACCA, EPA Region 3 in Philadelphia was working with the Wetlands and Watershed Work Group, a non-profit organization involved in wetlands policy and management along with the Federal Highway Administration (FHWA) on their own Green Highways initiative. These groups were planning a conference, the 'Green Highway Forum'. This was held in College Park, Maryland at the University of Maryland, Nov 8-10 2005. At the conference a draft 'roadmap' was presented as a guide to executive level participants bringing the diverse viewpoints of many agencies and interest groups together. Ten guiding principals were considered. The 'Green Highways' is a new effort to recognize the 'greenness' of many projects already completed and those to be initiated. 2 photos.

  5. Autoimmune diseases and infections as risk factors for schizophrenia

    DEFF Research Database (Denmark)

    Benros, Michael E; Mortensen, Preben B; Eaton, William W

    2012-01-01

    Immunological hypotheses have become increasingly prominent when studying the etiology of schizophrenia. Autoimmune diseases, and especially the number of infections requiring hospitalization, have been identified as significant risk factors for schizophrenia in a dose-response relationship, whic...... diseases and infections should be considered in the treatment of individuals with schizophrenia symptoms, and further research is needed of the immune system's possible contributing pathogenic factors in the etiology of schizophrenia....

  6. Media activism as movement?: collective identity formation in the World Forum of Free Media

    OpenAIRE

    Stephansen, Hilde C.

    2017-01-01

    More than simply tools used by social movements to reach other substantive aims, media are increasingly becoming subjects of activism. This article contributes to advancing understanding of such media-focused activism through a case study of the World Forum of Free Media, a thematic forum for media activists and media advocacy organisations linked to the World Social Forum. Based on qualitative research conducted between 2008 and 2016 -including participant observation, in-depth interviews an...

  7. Forum-ing: Signature practice for public theological discourse

    Directory of Open Access Journals (Sweden)

    Edward P. Wimberly

    2014-05-01

    Full Text Available This article introduces a unique model for public theological conversation and discourse, which was developed by the Concerned Black Clergy of Atlanta (CBC. It was a model developed in response to the problems of poverty, homelessness, and the ‘missing and murdered children’ victimised in Atlanta, Georgia in the United States of America in the early 1980s. It was originally organised to respond to the economic, financial, spiritual, emotional, employment, housing and resource needs of the underserved poor. This unique practice is called forum-ing. The forum meets every Monday morning, except when there is a national holiday. It has operated 30 consecutive years. The forum has a series of presentations, including the opening prayer, self-introductions of each person, a report of the executive director, special presentations from selected community groups, reports, and then questions and answers. The end result is that those attending engage in a process of discourse that enables them to internalise new ideas, approaches, and activities for addressing poverty and injustice in the community. Key to forum-ing for the 21st century is that it is a form of public practical theology rooted and grounded in non-violence growing out of the civil rights movement of the 1950s and 1960s in the United States. The overall purpose of this article is to contribute to the effort of the Faculty of Theology at the University of Pretoria (South Africa to identify those variables that will assist religious leaders in South Africa to develop public conversational spaces to enhance democratic participation. This article presents one model from the African American community in Atlanta, Georgia. The hope is to lift up key variables that might assist in the practical and pastoral theological conversation taking place in South Africa at present.

  8. Aging women with schizophrenia.

    Science.gov (United States)

    Pentland, Wendy; Miscio, Gina; Eastabrook, Shirley; Krupa, Terry

    2003-01-01

    The purpose of this study was to describe the aging experiences of women with schizophrenia. The research focused on how participants viewed their own aging with schizophrenia, their perceived worries and concerns and how they were coping with aging with the disorder. Using a qualitative approach, data were collected using multiple in-depth interviews with six participants selected purposefully from the client list of a community mental health center. Interview transcriptions were coded and analyzed according to the study questions using QSR Nudist 4 software. Several categories and sub-categories emerged. These included the improvement in the illness over time; physical and daily living activity limitations; specific positive and negative changes that the women report have accompanied aging; the profound losses experienced by the participants when they were younger as a result of having schizophrenia; and how these losses have affected their present lives in terms of limiting available informal support, creating dependency on formal programs and services, and participants' fears of the future. Based on the study findings, implications for mental health practice and services are considered and suggestions are made to guide future research.

  9. A Proposed Model for Authenticating Knowledge Transfer in Online Discussion Forums

    Science.gov (United States)

    Tucker, Jan P.; YoungGonzaga, Stephanie; Krause, Jaclyn

    2014-01-01

    Discussion forums are often utilized in the online classroom to build a sense of community, encourage collaboration and exchange, and measure time on task. A review of the literature revealed that there is little research that examines the role of the online discussion forum as a mechanism for knowledge transfer. Researchers reviewed 21 course…

  10. Meta-Ethnography of Qualitative Research on the Experience of Being a Partner to an Individual with Schizophrenia Spectrum Disorder.

    Science.gov (United States)

    Lewis, Laura Foran

    2017-03-01

    Several qualitative studies explore the experience of being a partner to an individual with schizophrenia spectrum disorder, but these studies remain isolated "islands of knowledge." This meta-ethnography aimed to synthesize current qualitative studies using Noblit and Hare's method. Thirteen studies were identified for inclusion. Three overarching themes were revealed: unmet expectations of relationship, renegotiating relationship roles, and separation versus togetherness. Themes interacted as a cycle with separation versus togetherness as temporal endpoints. Partners also renegotiated relationships with mental health professionals to accommodate unmet expectations. Leverage points for intervention were identified.

  11. One decade of functional imaging in schizophrenia research. From visualisation of basic information processing steps to molecular brain imaging

    International Nuclear Information System (INIS)

    Tost, H.; Meyer-Lindenberg, A.; Ruf, M.; Demirakca, T.; Grimm, O.; Henn, F.A.; Ende, G.

    2005-01-01

    Modern neuroimaging techniques such as magnetic resonance imaging (MRI) and positron emission tomography (PET) have contributed tremendously to our current understanding of psychiatric disorders in the context of functional, biochemical and microstructural alterations of the brain. Since the mid-nineties, functional MRI has provided major insights into the neurobiological correlates of signs and symptoms in schizophrenia. The current paper reviews important fMRI studies of the past decade in the domains of motor, visual, auditory, attentional and working memory function. Special emphasis is given to new methodological approaches, such as the visualisation of medication effects and the functional characterisation of risk genes. (orig.) [de

  12. 17. telekomunikacioni forum TELFOR 2009

    Directory of Open Access Journals (Sweden)

    Nebojša N. Gaćeša

    2010-04-01

    Full Text Available U Beogradu je 24, 25. i 26. novembra 2009. godine, u Sava centru, održan 17. telekomunikacioni forum TELFOR 2009, u organizaciji Društva za telekomunikacije – Beograd, „Telekom Srbija“ a. d., JP PTT saobraćaja „Srbija“, Elektrotehničkog fakulteta Univerziteta u Beogradu i IEEE Serbia & Montenegro ComSoc Chapter and Section. Telekomunikacioni forum TELFOR organizuje se sedamnaesti put kao domaći i regionalni godišnji skup stručnjaka koji rade u oblastima telekomunikacija i informacionih tehnologija. Učesnici su uglavnom telekomunikacioni inženjeri, ali i ekonomisti, pravnici, menadžeri, operatori i drugi. Na taj način TELFOR predstavlja forum u okviru kojeg se razmatraju sva relevantna pitanja telekomunikacija: tehnička, razvojna, regulatorna i ekonomska, pitanja proizvodnje opreme, usluga, servisa i funkcionisanja sistema.

  13. Virtual voices: social support and stigma in postnatal mental illness Internet forums.

    Science.gov (United States)

    Moore, Donna; Ayers, Susan

    2017-06-01

    Many women with postnatal mental illness do not get the treatment they need and this is often because stigma prevents disclosure. The purpose of this study was to explore online social support for postnatal mental illness, how women experience stigma and potential disadvantages of using Internet forums. Interviews were conducted with fifteen participants who had suffered postnatal mental illness and had used forums. Systematic thematic analysis identified common themes in relation to social support, stigma and disadvantages of using forums. Most women felt they benefited from visiting forums by developing a shared understanding and discourse about their illness. Findings suggest future research should investigate if women benefit from using online social support provided by forums, if use challenges stigma and further explore potential concerns about using forums.

  14. Users’ attention behaviors and features in internet forum

    Directory of Open Access Journals (Sweden)

    Yong-Zhong Sha

    2015-11-01

    Full Text Available Purpose: Attention resource is scarce. Organizing community activities in online forums faces the challenge of attracting users’ limited attention. Understanding how users of online forums allocate, maintain, and change their attentional focus and what features of online forms influence their attention behaviors is critical for effective information design. This paper seeks understanding of users’ attention behaviors and features when they participate in discussions in online forums. Design/methodology/approach: A conceptual model was established to explore the indicator system of attention’s measurement. The related attention data were collected from Alexa Access Statistics Tool and Katie community. Then this paper computed the correlation coefficient and regression relationship between the indicators of visual attention and cognitive attention. Thereafter this paper analyzed and discussed users’ attention behaviors and features in Internet forum. Findings: Relevant bivariate correlation analysis and regression analysis discovers that Internet forum's attention is mainly as visual attention in users’ early involvement. Attention resources can be transformed. In a deep participation, users’ cognitive attention is more significant. Meanwhile cognitive attention behaviors’ further development will lead to the phenomenon that cognitive attention input is prone to increase faster in the early duration. That means in-depth discussion and interaction are more likely to appear in the early stages of participation. Research limitations/implications: There are some limitations about this study. The indicators are not comprehensive enough because factors affecting the distribution of attention resources in Internet forums are complex. We didn’t distinguish different types of Internet forums when we collected the relevant data. Future research will focus more on how to obtain comprehensive attention data. Originality/value: T his paper

  15. Involving children and young people in clinical research through the forum of a European Young Persons' Advisory Group: needs and challenges.

    Science.gov (United States)

    Gaillard, Segolene; Malik, Salma; Preston, Jenny; Escalera, Begonya Nafria; Dicks, Pamela; Touil, Nathalie; Mardirossian, Sandrine; Claverol-Torres, Joana; Kassaï, Behrouz

    2018-02-19

    Children and young people are seen as fundamental to the design and delivery of clinical research as active and reflective participants. In Europe, involvement of children and young people in clinical research is promoted extensively in order to engage young people in research as partners and to give them a voice to raise their own issues or opinions and for their involvement in planning and decision making in addition to learning research skills. Children and young people can be trained in clinical research through participation in young person advisory groups (YPAGs). Members of YPAGs assist other children and young people to learn about clinical research and share their experience and point of view with researchers, thereby possibly influencing all phases of research including the development and prioritization of research questions, design and methods, recruitment plans, and strategies for results dissemination. In the long term, the expansion of YPAGs in Europe will serve as a driving force for refining pediatric clinical research. It will help in a better definition of research projects according to the patients' needs. Furthermore, direct engagement of children and young people in research will be favorable to both researchers and young people. © 2018 Société Française de Pharmacologie et de Thérapeutique.

  16. Scene construction in schizophrenia.

    Science.gov (United States)

    Raffard, Stéphane; D'Argembeau, Arnaud; Bayard, Sophie; Boulenger, Jean-Philippe; Van der Linden, Martial

    2010-09-01

    Recent research has revealed that schizophrenia patients are impaired in remembering the past and imagining the future. In this study, we examined patients' ability to engage in scene construction (i.e., the process of mentally generating and maintaining a complex and coherent scene), which is a key part of retrieving past experiences and episodic future thinking. 24 participants with schizophrenia and 25 healthy controls were asked to imagine new fictitious experiences and described their mental representations of the scenes in as much detail as possible. Descriptions were scored according to various dimensions (e.g., sensory details, spatial reference), and participants also provided ratings of their subjective experience when imagining the scenes (e.g., their sense of presence, the perceived similarity of imagined events to past experiences). Imagined scenes contained less phenomenological details (d = 1.11) and were more fragmented (d = 2.81) in schizophrenia patients compared to controls. Furthermore, positive symptoms were positively correlated to the sense of presence (r = .43) and the perceived similarity of imagined events to past episodes (r = .47), whereas negative symptoms were negatively related to the overall richness of the imagined scenes (r = -.43). The results suggest that schizophrenic patients' impairments in remembering the past and imagining the future are, at least in part, due to deficits in the process of scene construction. The relationships between the characteristics of imagined scenes and positive and negative symptoms could be related to reality monitoring deficits and difficulties in strategic retrieval processes, respectively. Copyright 2010 APA, all rights reserved.

  17. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Pictured here in front of String 2 - the full-scale test facility for LHC sytems - are (left to right) H. Wenninger, Mme M. Quirina, Mme Marie-Anne Heimo, N. Siegel, Mme Konrade Von Bremen, Prof. Roger Berthouzoz, Mme Thérèse Wolf, Prof. Dr. Med. Bernard Mach and M. Alexander Höchli.

  18. Bridging the Measurement Gap Between Research and Clinical Care in Schizophrenia: Positive and Negative Syndrome Scale-6 (PANSS-6) and Other Assessments Based on the Simplified Negative and Positive Symptoms Interview (SNAPSI).

    Science.gov (United States)

    Østergaard, Søren D; Opler, Mark G A; Correll, Christoph U

    2017-12-01

    There is currently a "measurement gap" between research and clinical care in schizophrenia. The main reason behind this gap is that the most widely used rating scale in schizophrenia research, the 30-item Positive and Negative Syndrome Scale (PANSS), takes so long to administer that it is rarely used in clinical practice. This compromises the translation of research findings into clinical care and vice versa. The aim of this paper is to discuss how this measurement gap can be closed. Specifically, the main points of discussion are 1) the practical problems associated with using the full 30-item PANSS in clinical practice; 2) how the brief, six-item version of the Positive and Negative Syndrome Scale (PANSS-6) was derived empirically from the full 30-item PANSS and what the initial results obtained with PANSS-6 entail; and 3) how PANSS-6 ratings, guided by the newly developed, 15-25-minute, stand-alone Simplified Negative and Positive Symptoms Interview (SNAPSI), might help bridge the measurement gap between research and clinical care in schizophrenia. The full 30-item PANSS is often used in research studies, but is too time consuming to allow for routine clinical use. Recent studies suggest that the much briefer PANSS-6 is a psychometrically valid measure of core positive and negative symptoms of schizophrenia and that the scale is sensitive to symptom improvement following pharmacological treatment. SNAPSI is a brief interview that yields the information needed to rate PANSS-6 (and other brief rating scales). We believe that PANSS-6 ratings guided by SNAPSI will help bridge the measurement gap between research and clinical care in schizophrenia.

  19. HP-SEE User Forum 2012

    CERN Document Server

    Karaivanova, Aneta; Oulas, Anastasis; Liabotis, Ioannis; Stojiljkovic, Danica; Prnjat, Ognjen

    2014-01-01

    This book is a collection of carefully reviewed papers presented during the HP-SEE User Forum, the meeting of the High-Performance Computing Infrastructure for South East Europe’s (HP-SEE) Research Communities, held in October 17-19, 2012, in Belgrade, Serbia. HP-SEE aims at supporting and integrating regional HPC infrastructures; implementing solutions for HPC in the region; and making HPC resources available to research communities in SEE, region, which are working in a number of scientific fields with specific needs for massively parallel execution on powerful computing resources. HP-SEE brings together research communities and HPC operators from 14 different countries and enables them to share HPC facilities, software, tools, data and research results, thus fostering collaboration and strengthening the regional and national human network; the project specifically supports research groups in the areas of computational physics, computational chemistry and the life sciences. The contributions presented i...

  20. Proceedings of the 2008 transportation technologies and fuels forum

    International Nuclear Information System (INIS)

    2008-01-01

    As a large emitter of pollutants, the transportation industry is now seeking to develop a sustainable transportation plan for the future by developing methods of reducing emissions and improving the fuel efficiency of vehicles. This forum discussed recent innovations in vehicle transportation technologies. Industry leaders, government representatives, and researchers discussed methods of reducing greenhouse gases (GHGs) and air pollution in the transportation sector. Advanced combustion technologies were outlined, and recent developments in hybrid electric-powered vehicles were discussed. Research related to fuel cells, hydrogen fuels and biofuels was presented. The impacts of polluting vehicles on public health were also discussed. The forum was divided into the following 5 sessions: (1) setting the scene, (2) future fuels, (3) emissions, (4) EVs now, and (5) the road to the future. The sessions were followed by a panel on technology roadmaps. The forum featured 14 presentations, of which 4 have been catalogued separately for inclusion in this database. tabs., figs.

  1. Emotional isolation in BBC Forum

    International Nuclear Information System (INIS)

    Sienkiewicz, J; Chmiel, A

    2014-01-01

    We analyze emotionally annotated massive data from BBC Forum and examine properties of the isolation phenomenon of negative and positive users. Our results show the existence of a percolation threshold dependent on the average emotional value in the network of negatively charged nodes

  2. 11. Rostock bioenergy forum. Proceedings

    International Nuclear Information System (INIS)

    Nelles, Michael

    2017-01-01

    The seven main focus of the bioenergy forum were: 1. Political regulation and its consequences; 2. Flexible energy supply; 3. Biorefineries for the use of residues from bioenergy production; 4. Process optimization biogas; 5. Alternative substrates for biogas production; 6. Cross-sectoral bioenergy concept; 7. Transport sector (biofuels). Five lectures are separately analyzed for this database. [de

  3. Emotion in Schizophrenia: Where Feeling Meets Thinking

    OpenAIRE

    Kring, Ann M.; Caponigro, Janelle M.

    2010-01-01

    Our understanding of the nature of emotional difficulties in schizophrenia has been greatly enhanced by translational research over the past two decades. By incorporating methods and theories from affective science, researchers have been able to discover that people with schizophrenia exhibit very few outward displays of emotion but report experiencing strong feelings in the presence of emotionally evocative stimuli or events. Recent behavioral, psychophysiological, and brain imaging research...

  4. Safety approach and research and development presentation for the selected systems of the International forum Generation IV; Elements de l'approche de surete et themes de R et D specifiques pour les systemes selectionnes par le Forum International Generation 4

    Energy Technology Data Exchange (ETDEWEB)

    Fiorini, G.L. [CEA Saclay, Dir. du Developpement et de l' Innovation Nucleares (DEN/DDIN), 91 - Gif Sur Yvette (France)

    2003-07-01

    This paper deals with the six projects of the Generation IV forum: Sodium Fast reactor, lead fast reactor, gas fast reactor, very high temperature reactor, supercritical water reactor, molten salt reactor. The technical objectives of the reactor safety and the design/evaluation approach are discussed. (A.L.B.)

  5. Envisioning Instructional Communication Research as a Multi-Paradigmatic Response to Neoliberalism's Effect on Instruction. Forum: The Future of Instructional Communication

    Science.gov (United States)

    Kahl, David H., Jr.

    2017-01-01

    Throughout its history, instructional communication research has played an important role in the discipline of Communication. In tracing its lineage, Myers (2010) explains that instructional communication research has focused on communicative behaviors that instructors use with their students to better understand and facilitate affective and…

  6. Common variants conferring risk of schizophrenia

    DEFF Research Database (Denmark)

    Stefansson, Hreinn; Ophoff, Roel A; Steinberg, Stacy

    2009-01-01

    Schizophrenia is a complex disorder, caused by both genetic and environmental factors and their interactions. Research on pathogenesis has traditionally focused on neurotransmitter systems in the brain, particularly those involving dopamine. Schizophrenia has been considered a separate disease...... conform to classical nosological disease boundaries. Certain CNVs confer not only high relative risk of schizophrenia but also of other psychiatric disorders. The structural variations associated with schizophrenia can involve several genes and the phenotypic syndromes, or the 'genomic disorders', have.......2. Our findings implicating the MHC region are consistent with an immune component to schizophrenia risk, whereas the association with NRGN and TCF4 points to perturbation of pathways involved in brain development, memory and cognition....

  7. Registered criminality and sanctioning of schizophrenia patients

    DEFF Research Database (Denmark)

    Munkner, Runa; Haastrup, Soeren; Joergensen, Torben

    2009-01-01

    BACKGROUND: Patients with schizophrenia have been shown to have an increased risk of criminality, especially violent crimes. AIMS: The aim of the current study was to describe the pattern of crimes committed by Danish patients with schizophrenia and examine the sanctions given for crimes...... in relation to the different periods in the patients' lives: not yet known to the psychiatric hospital system, known to the system but not yet diagnosed with schizophrenia, and after being diagnosed with schizophrenia. METHODS: Information from the Danish Psychiatric Central Research Register was correlated...... with data from the Danish National Crime Register. RESULTS: One of the more prominent findings was that 16% of patients diagnosed with schizophrenia receive a prison sentence or a suspended prison sentence, despite the fact that Denmark is a co-signatory of the European Prison Rules and should treat, rather...

  8. Beyond “Political” Communicative Spaces : Talking Politics on the Wife Swap Discussion Forum

    NARCIS (Netherlands)

    Graham, T.S.

    2012-01-01

    Net-based public sphere researchers have examined online deliberation in numerous ways. However, most studies have focused exclusively on political discussion forums. This article moves beyond such spaces by analyzing political talk from an online forum dedicated to reality television. The purpose

  9. Students' Learning in Asynchronous Discussion Forums: A Meta-Analysis

    Science.gov (United States)

    Martono, Fkipuntan; Salam, Urai

    2017-01-01

    Asynchronous discussion forums are among the most preferred tools chosen to foster learning opportunities and knowledge construction. To reveal the cognitive engagement evidenced in the transcripts of the discussion forums, this study presents 51 papers. 17 papers reported research on students' attitude toward the use of ICT for learning, 16…

  10. How a moderated online discussion forum facilitates support for young people with eating disorders.

    Science.gov (United States)

    Kendal, Sarah; Kirk, Sue; Elvey, Rebecca; Catchpole, Roger; Pryjmachuk, Steven

    2017-02-01

    Young people with eating disorders are at risk of harm to their social, emotional and physical development and life chances. Although they can be reluctant to seek help, they may access social media for information, advice or support. The relationship between social media and youth well-being is an emotive subject, but not clearly understood. This qualitative study aimed to explore how young people used a youth-orientated, moderated, online, eating disorders discussion forum, run by an eating disorders charity. We applied a netnographic approach involving downloading and thematically analysing over 400 messages posted August-November 2012. Data analysis generated five themes: Taking on the role of mentor; the online discussion forum as a safe space; Friendship within the online forum; Flexible help; and Peer support for recovery and relapse prevention. Forum moderation may have influenced the forum culture. Our findings are consistent with literature about youth preferences for mental health self-care support. A young person's decision to use this discussion forum can be construed as pro-active self-care. A moderated online discussion forum can make a positive contribution to support for youth with eating disorders, countering negative media perceptions of online groups. This study adds to knowledge about how young people access support via social media. Online discussion forums can be safe and acceptable spaces for youth to access help. Further research could provide insights into the impact of forum moderation. © 2016 The Authors. Health Expectations Published by John Wiley & Sons Ltd.

  11. Family intervention for schizophrenia.

    Science.gov (United States)

    Pharoah, F M; Mari, J J; Streiner, D

    2000-01-01

    It has been showed that people with schizophrenia from families that express high levels of criticism, hostility, or over involvement, have more frequent relapses than people with similar problems from families that tend to be less expressive of their emotions. Psychosocial interventions designed to reduce these levels of expressed emotions within families now exist for mental health workers. These interventions are proposed as adjuncts rather than alternatives to drug treatments, and their main purpose is to decrease the stress within the family and also the rate of relapse. To estimate the effects of family psychosocial interventions in community settings for the care of those with schizophrenia or schizophrenia-like conditions compared to standard care. Electronic searches of the Cochrane Library (Issue 2, 1998), the Cochrane Schizophrenia Group's Register (June 1998), EMBASE (1981-1995) and MEDLINE (1966-1995) were undertaken and supplemented with reference searching of the identified literature. Randomised or quasi-randomised studies were selected if they focused on families of people with schizophrenia or schizoaffective disorder and compared community-orientated family-based psychosocial intervention of more than five sessions to standard care. Data were reliably extracted, and, where appropriate and possible, summated. Peto odds ratios (OR), their 95% confidence intervals (CI) and number needed to treat (NNT) were estimated. The reviewers assume that people who died or dropped out had no improvement and tested the sensitivity of the final results to this assumption. Family intervention may decrease the frequency of relapse (one year OR 0.57 CI 0.4-0.8, NNT 6.5 CI 4-14). The trend over time of this main finding is towards the null and some small but negative studies may not have been identified by the search. Family intervention may decrease hospitalisation and encourage compliance with medication but data are few and equivocal. Family intervention does not

  12. Schizophrenia: Hope on the Horizon.

    Science.gov (United States)

    Sullivan, Patrick F

    2015-01-01

    In July 2014, an international consortium of schizophrenia researchers co-founded by the author mounted the largest biological experiment in the history of psychiatry and found eighty new regions in the genome associated with the illness. With many more avenues for exploring the biological underpinnings of schizophrenia now available to neuroscientists, hope may be on the way for the estimated 2.4 million Americans and 1 in 100 people worldwide affected by the illness, one in which drugs have limited impact and there is no known cure.

  13. Do schizophrenia patients age early?

    Science.gov (United States)

    Shivakumar, Venkataram; Kalmady, Sunil V; Venkatasubramanian, Ganesan; Ravi, Vasanthapuram; Gangadhar, Bangalore N

    2014-08-01

    The etiopathogenesis of schizophrenia is poorly understood. Within the proposed "neurodegeneration paradigm", observations have been put forth for "accelerated aging" in this disorder. This proposition is largely based on the neuroscience research that demonstrates progressive changes in brain as well as other systemic abnormalities supportive of faster aging process in patients with this disorder. In this review, we have summarized the literature related to the concept of early aging in schizophrenia. These studies include P300 abnormalities & visual motion discrimination, neuroimaging findings, telomere dynamics as well as neuropathology of related brain regions. We also propose a role of vitamin D, neuroimmunological changes and elevated oxidative stress as well as mitochondrial dysfunction in addition to the above factors with 'vitamin-D deficiency' as the central paradox. Put together, the evidence supporting early aging in schizophrenia is compelling and this requires further systematic studies. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. Build Locally, Link Globally: The Social Forum Process in Italy

    Directory of Open Access Journals (Sweden)

    Donatella della Porta

    2015-08-01

    Full Text Available Considered an innovation because of its capacity to develop transnational processes, the World Social Forum however also has strong local roots as well as effects on organizational models and collective identities at the domestic level. Focusing on the Italian case, this article shows how local social forums, as arenas for exchanges of ideas, played a cognitive role in the import, but also the translation of new ideas, as well as helping the emergence of dense network structures and tolerant identities. The first section of the article examines how local social forums contributed to innovation in the organizational formulas of the Global Justice Movement—considering both structure (organizations and process (methodologies aspects—through the development of different, more participatory conceptions of internal decision making. It then addresses the innovations in the definition of collective identities, stressing the linkages of local struggles and global framing as well as the development of a cross-issue discourse around an anti-neoliberal frame. The final section will discuss the contribution of local social forums to contemporary social movements, stressing the role of these new arenas for the cross-fertilization among different movement families and spreading a method of working together that becomes part of the repertoire of action of local social movement organizations. The empirical research consists mainly of in-depth interviews and focus groups with activists from social movement organizations which were involved in local social forums.

  15. JASAL Forum 2011: Growing Trends in Self-Access Learning

    Directory of Open Access Journals (Sweden)

    Azusa Kodate

    2012-03-01

    Full Text Available The annual JASAL forum was held in Tokyo in 2011 in keeping with the theme of the JALT 2011 conference, ‘Teaching, Learning, and Growing’.Drawing on the theme of this year’s JASAL forum, ‘Growing Trends in Self-Access Learning’, several different trends emerged from the two paper and five poster presentations that illustrate the ongoing growth of the field. Contents of the presentations varied widely from an administrative operation of a self-access centre (hereafter SAC to research findings about SAC users. Having approximately 45 people including presenters at the forum, active discussions in which they shared ideas and professional practices were generated. One of the common points which emerged in the forum was that the form of learning that SACs provide is becoming more accepted and valued by educational institutions, and this has led to an increase in the number of SACs nationwide in Japan. Against this background, three themes were evident in the presentations given at this year’s forum: focusing on the physical learning environment, providing easier access to learners, and supporting learning processes.

  16. Factors associated with relapse in schizophrenia

    African Journals Online (AJOL)

    increases the economic burden on health care systems because of its associated morbidity .... Depression in schizophrenia has been associated with higher rates of relapse ... The researchers approached the psychiatric nursing staff of mental.

  17. [Decision-making and schizophrenia].

    Science.gov (United States)

    Adida, M; Maurel, M; Kaladjian, A; Fakra, E; Lazerges, P; Da Fonseca, D; Belzeaux, R; Cermolacce, M; Azorin, J-M

    2011-12-01

    Abnormalities involving the prefrontal cortex (PFC) have long been postulated to underpin the pathophysiology of schizophrenia. Investigations of PFC integrity have focused mainly on the dorsolateral PFC (DLPFC) and abnormalities in this region have been extensively documented. However, defects in schizophrenia may extend to other prefrontal regions, including the ventromedial PFC (VMPFC), and evidence of VMPFC abnormalities comes from neuropathological, structural and functional studies. Patients with acquired brain injury to the VMPFC display profound disruption of social behaviour and poor judgment in their personal lives. The Iowa Gambling Task (IGT) was developed to assess decision-making in these neurological cases : it presents a series of 100 choices from four card decks that differ in the distribution of rewarding and punishing outcomes. Whilst healthy volunteers gradually develop a preference for the two "safe" decks over the course of the task, patients with VMPFC lesions maintain a preference for the two "risky" decks which are associated with high reinforcement in the short term, but significant long-term debt. Interestingly, damage to VMPFC may cause both poor performance on the IGT and lack of insight concerning the acquired personality modification. Recently, our group reported a trait-related decisionmaking impairment in the three phases of bipolar disorder. In a PET study, VMPFC dysfunction was shown in bipolar manic patients impaired on a decision-making task and an association between decision-making cognition and lack of insight was described in mania. A quantitative association between grey matter volume of VMPFC and memory impairment was previously reported in schizophrenia. Research suggests that lack of insight is a prevalent feature in schizophrenia patients, like auditory hallucinations, paranoid or bizarre delusions, and disorganized speech and thinking. Because schizophrenia is associated with significant social or occupational

  18. Forum: Interpersonal Communication in Instructional Settings. A Cautious Approach to Reliance on Interpersonal Communication Frameworks: The Importance of Context in Instructional Communication Research

    Science.gov (United States)

    Johnson, Zac D.; LaBelle, Sara; Waldeck, Jennifer H.

    2017-01-01

    Instructional communication (IC) scholars have made significant contributions to the study of educational outcomes by creating a deep understanding of the teacher-student relationship (Mottet & Beebe, 2006). IC research published in "Communication Education" and other outlets therefore appropriately emphasizes interpersonal…

  19. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996. He is seen here visiting building SM18, which houses String 2: the test facility for LHC systems. Photo 01: (left to right) Mme Jaconi, Prof. Roger Berthouzoz, M. Guillaume Pictet, M. Claude Bagnoud, R. Saban and Hubert Curien. Photo 02: (left to right) R. Saban, M. Jean-Claude Rochat, Hubert Curien and M. Guillaume Pictet. Photo 03: (left to right) R. Saban, M. Jean-Claude Rochat and Hubert Curien.

  20. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996. Photo 01: (left to right) Mrs Mireille Quirina; D. Denegri, Physics Coordinator, CMS experiment; and Mrs Marisa Jaconi at the CMS detector's assembly site. In the background is the CMS magnet system under construction. The red concentric rings are part of the barrel yoke, which returns the magnetic flux generated by the superconducting coil. Supported from the innermost barrel ring is the outer cylinder of the vacuum tank that will house the superconducting coil.

  1. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996. Photo 01: (left to right) Konrade Von Bremen, Claude-Olivier Rochat, T. Virdee and Guillaume Pictet in front of one of the two end-caps of the CMS detector at the assembly site. The brass structure in the top right-hand corner is part of the hadronic calorimeter that will measure the energy of strongly interacting particles produced in collisions at the LHC.

  2. Identifying Gene-Environment Interactions in Schizophrenia

    DEFF Research Database (Denmark)

    van Os, Jim; Rutten, Bart P; Myin-Germeys, Inez

    2014-01-01

    Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual...... of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap...

  3. Nuclear waste disposal educational forum

    International Nuclear Information System (INIS)

    1982-01-01

    In keeping with a mandate from the US Congress to provide opportunities for consumer education and information and to seek consumer input on national issues, the Department of Energy's Office of Consumer Affairs held a three-hour educational forum on the proposed nuclear waste disposal legislation. Nearly one hundred representatives of consumer, public interest, civic and environmental organizations were invited to attend. Consumer affairs professionals of utility companies across the country were also invited to attend the forum. The following six papers were presented: historical perspectives; status of legislation (Senate); status of legislation (House of Representatives); impact on the legislation on electric utilities; impact of the legislation on consumers; implementing the legislation. All six papers have been abstracted and indexed for the Energy Data Base

  4. SCHIZOPHRENIA: A REVIEW

    OpenAIRE

    Parle Milind; Sharma Kailash

    2013-01-01

    Schizophrenia continues to be a mysterious disease fascinating the minds of psychiatrists, pharmacologists and neuroscientists all over the world for more than a century. The crucial welfare of the millions afflicted with schizophrenia is at stake. The cause of schizophrenia is not yet identified. However, it appears from the available reports that schizophrenia results from genetic, occupational and environmental risk factors, which act independently or combine synergistically to develop sch...

  5. EUROSAFE forum 2013. Safe disposal of nuclear waste

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-07-01

    The proceedings of the EUROSAFE forum 2013 - safe disposal of nuclear waste include contributions to the following topics: Nuclear installation safety - assessment; nuclear installation safety - research; waste and decommissioning - dismantling; radiation protection, 3nvironment and emergency preparedness; security of nuclear installations and materials.

  6. 3rd Session of the Sant Cugat Forum on Astrophysics

    CERN Document Server

    Gravitational wave astrophysics

    2015-01-01

    This book offers review chapters written by invited speakers of the 3rd Session of the Sant Cugat Forum on Astrophysics — Gravitational Waves Astrophysics. All chapters have been peer reviewed. The book goes beyond normal conference proceedings in that it provides a wide panorama of the astrophysics of gravitational waves and serves as a reference work for researchers in the field.

  7. Forum: Communication Activism Pedagogy. Four Typologies of Communication Activism Pedagogy

    Science.gov (United States)

    Hartnett, Stephen J.

    2017-01-01

    This concluding response to the articles in this forum maps out the main arguments in the responses to the stimulus essay, "Communication Activism Pedagogy and Research: Communication Education Scholarship to Promote Social Justice," which fall into four broad categories: (1) post-Marxist imaginings of social change; (2) existentialist…

  8. Proposed Federal Gun-Control Amendment. Student Forum.

    Science.gov (United States)

    Mertz, Gayle; Mertz, David

    1995-01-01

    Presents an outline for a student-run forum on a proposed federal gun control amendment. Procedures include mandatory reading assignments and researching the issue. Students role-play fictional representative characters and later facilitate discussions. Concludes with a vote on the amendment. (MJP)

  9. Online Groups and Patient Forums

    OpenAIRE

    Dosani, Sabina; Harding, Claire; Wilson, Simon

    2014-01-01

    Online mental health support forums are becoming increasingly popular and there is evidence that they are useful: particularly for providing anonymous support and filling information gaps. However, there are also very real concerns about negative outcomes for users. One online mental health service, Big White Wall, manages these risks and supports its members through the provision of 24 hour professional moderation. Comparison of Big White Wall’s member population with the population of one L...

  10. Conflict adaptation in patients diagnosed with schizophrenia.

    Science.gov (United States)

    Abrahamse, Elger; Ruitenberg, Marit; Boddewyn, Sarah; Oreel, Edith; de Schryver, Maarten; Morrens, Manuel; van Dijck, Jean-Philippe

    2017-11-01

    Cognitive control impairments may contribute strongly to the overall cognitive deficits observed in patients diagnosed with schizophrenia. In the current study we explore a specific cognitive control function referred to as conflict adaptation. Previous studies on conflict adaptation in schizophrenia showed equivocal results, and, moreover, were plagued by confounded research designs. Here we assessed for the first time conflict adaptation in schizophrenia with a design that avoided the major confounds of feature integration and stimulus-response contingency learning. Sixteen patients diagnosed with schizophrenia and sixteen healthy, matched controls performed a vocal Stroop task to determine the congruency sequence effect - a marker of conflict adaptation. A reliable congruency sequence effect was observed for both healthy controls and patients diagnosed with schizophrenia. These findings indicate that schizophrenia is not necessarily accompanied by impaired conflict adaptation. As schizophrenia has been related to abnormal functioning in core conflict adaptation areas such as anterior cingulate and dorsolateral prefrontal cortex, further research is required to better understand the precise impact of such abnormal brain functioning at the behavioral level. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Treatment of substance use disorders in schizophrenia.

    Science.gov (United States)

    Bennett, Melanie E; Bradshaw, Kristen R; Catalano, Lauren T

    2017-07-01

    Substance use disorders (SUDs) represent a great barrier to functional recovery for individuals with schizophrenia. It is important to use research on treatment of SUDs in schizophrenia to guide treatment recommendations and program planning. We review studies of pharmacological and psychosocial interventions to treat SUDs in individuals with schizophrenia. The criteria used to select studies for inclusion are (1) the percentage of the sample with a schizophrenia spectrum diagnosis is at least 25%; (2) participants have a comorbid SUD or problem use of substances; (3) an intervention for SUD is provided; (4) a substance use-related outcome is measured; and (5) the study design enabled examination of pre-post outcome measures including open label trials, nonrandomized evaluations (quasi-experimental designs, nonrandom assignment to groups), or randomized controlled trials. There are few psychopharmacology outcomes studies. Most have examined use of antipsychotic medications to treat SUDs in schizophrenia. Several trials have yielded positive findings for naltrexone in reducing drinking compared to placebo in this population. Motivational and cognitive-behavioral interventions are associated with decreased substance use in several trials. Treatment for SUDs is feasible within a range of settings and acceptable to many individuals with schizophrenia. All individuals with schizophrenia should be offered brief or more extended psychosocial interventions that incorporate discussion of personal reasons to change and training in cognitive-behavioral strategies to reduce use, cope with cravings and stress, and avoid relapse. Future research must include larger samples, longitudinal designs, and similar outcome measures across studies.

  12. First episode schizophrenia

    African Journals Online (AJOL)

    with schizophrenia present clinically with psychotic, negative and cognitive ... changes in their emotions, cognition or behaviour which may indicate a ... contribute 80% to the risk of schizophrenia developing. A number of .... Positive symptoms ... Depression ... treatment of first episode schizophrenia is of critical importance.

  13. Generation 4 International Forum. 2007 annual report

    International Nuclear Information System (INIS)

    2007-01-01

    This annual report is the first to be issued by GIF (Generation IV International Forum). It summarizes the GIF goals and accomplishments throughout 2007, describes its membership and organization, and provides an overview of its cooperation with other international endeavors for the development of nuclear energy. Future editions will focus on technical progress. Chapter 2 provides an overview on the goals of Generation IV nuclear energy systems and outlines the main characteristics of the six systems selected for joint development by GIF (VHTR - Very High Temperature Reactor; SFR - Sodium-cooled Fast Reactor; SCWR - Super-Critical Water cooled Reactor; GFR - Gas-cooled Fast Reactor; LFR - Lead-cooled Fast Reactor; and MSR - Molten Salt Reactor). Chapter 3 describes the membership and organization of the GIF, the structure of its cooperative research and development (R-D) arrangements, and the status of Member participation in these arrangements. Chapter 4 summarizes the R-D plans and achievements of the Forum until now. It highlights the R-D challenges facing the teams developing Generation IV systems and the major milestones towards the development of these systems. It also describes the progress made regarding the development of methodologies for assessing Generation IV systems with respect to the established goals. Chapter 5 reviews other major international collaborative projects in the field of nuclear energy and explains how the GIF interacts and cooperates with them. Bibliographical references are provided in each chapter in order to facilitate access to public information about the GIF objectives, goals and outcomes

  14. Forum on Specifications and Design Languages 2012

    CERN Document Server

    2014-01-01

    This book brings together a selection of the best papers from the fifteenth edition of the Forum on specification and Design Languages Conference (FDL), which was held in September 2012 at Vienna University of Technology, Vienna, Austria.  FDL is a well-established international forum devoted to dissemination of research results, practical experiences and new ideas in the application of specification, design and verification languages to the design, modeling and verification of integrated circuits, complex hardware/software embedded systems, and mixed-technology systems.  ·         Covers Assertion Based Design, Verification & Debug; ·         Includes language-based modeling and design techniques for embedded systems; ·         Covers design, modeling and verification of mixed physical domain and mixed signal systems that include significant analog parts in electrical and non-electrical domains; ·         Includes formal and semi-formal system level design methods fo...

  15. Proceedings of the Flat-Plate Solar Array Project Research Forum on the Design of Flat-Plate Photovoltaic Arrays for Central Stations

    Science.gov (United States)

    1983-01-01

    The Flat Plate Solar Array Project, focuses on advancing technologies relevant to the design and construction of megawatt level central station systems. Photovoltaic modules and arrays for flat plate central station or other large scale electric power production facilities require the establishment of a technical base that resolves design issues and results in practical and cost effective configurations. Design, qualification and maintenance issues related to central station arrays derived from the engineering and operating experiences of early applications and parallel laboratory reserch activities are investigated. Technical issues are examined from the viewpoint of the utility engineer, architect/engineer and laboratory researcher. Topics on optimum source circuit designs, module insulation design for high system voltages, array safety, structural interface design, measurements, and array operation and maintenance are discussed.

  16. No Evidence That Schizophrenia Candidate Genes Are More Associated With Schizophrenia Than Noncandidate Genes.

    Science.gov (United States)

    Johnson, Emma C; Border, Richard; Melroy-Greif, Whitney E; de Leeuw, Christiaan A; Ehringer, Marissa A; Keller, Matthew C

    2017-11-15

    A recent analysis of 25 historical candidate gene polymorphisms for schizophrenia in the largest genome-wide association study conducted to date suggested that these commonly studied variants were no more associated with the disorder than would be expected by chance. However, the same study identified other variants within those candidate genes that demonstrated genome-wide significant associations with schizophrenia. As such, it is possible that variants within historic schizophrenia candidate genes are associated with schizophrenia at levels above those expected by chance, even if the most-studied specific polymorphisms are not. The present study used association statistics from the largest schizophrenia genome-wide association study conducted to date as input to a gene set analysis to investigate whether variants within schizophrenia candidate genes are enriched for association with schizophrenia. As a group, variants in the most-studied candidate genes were no more associated with schizophrenia than were variants in control sets of noncandidate genes. While a small subset of candidate genes did appear to be significantly associated with schizophrenia, these genes were not particularly noteworthy given the large number of more strongly associated noncandidate genes. The history of schizophrenia research should serve as a cautionary tale to candidate gene investigators examining other phenotypes: our findings indicate that the most investigated candidate gene hypotheses of schizophrenia are not well supported by genome-wide association studies, and it is likely that this will be the case for other complex traits as well. Copyright © 2017 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

  17. Kreapelin's Scientific Value of his Clinical Observations in the Research of Thought and Language Disorders in Schizophrenia

    Directory of Open Access Journals (Sweden)

    Maria Luísa Figueira

    2014-10-01

    Full Text Available During the transition of the XIX to the XXth century, several changes took place in the dominant moral psychiatric paradigm. In the movement, that opposes the former romantic and normative vision of behaviour and intentions, the primacy of observation and description emerges as a superior clinical method, organizing knowledge and investigation. Kraepelin in one of the main figures that emerges, with a remarkable masterpiece, his "Treatise of Psychiatry", including several editions, each one resulting in reformulations according to the new data he obtained. Comparing Kraepelin's work - or other contemporary authors - with posterior essays on thought and language in shizophrenia would be incongruous, because the irreducibility of a clinical to an experimental method. The aim of this paper is merely to show the relation between clinical descriptions and the resulting hypothesis or constructs. Description is viewed as a systematic exploration of the psychopathological reality and an important source of scientific intuitions. This is what has happened with the work of Kraepelin, Bleuler and many others, from which we can extrapolate the ideas for knowledge produced in laboratorial context. In particular, we shall review investigation data about thought and language, produced between the sixties and the eighties, a very fertile scientific period in this area of knowledge and, which has, almost disappeared. In fact, today's literaure about thought diosorder in schizophrenia is based predominantly on the neuropsychological paradigm with the use of test batteries that evaluate cognitive deficits. The importance of this perspective is that it enables the development of response indicators with the psychopharmacological therapies and the implementation of rehabilitation programs. However, it doesn't contain the richness of the period mentioned earlier. We chose some of the particular aspects of cognitive functioning to illustrate the influence of Kraepelin

  18. [Theory of mind in schizophrenia].

    Science.gov (United States)

    Bonshtein, Udi

    2006-12-01

    The term "theory of mind" (ToM) refers to the capacity to infer one's own and other persons' mental states (e.g. their beliefs, feelings, intentions or knowledge). It was found that children in the autistic spectrum have deficits in ToM. One of the suggestions was that unlike autistic people, ToM skills are normally developed in schizophrenia patients, but "lost" in the first psychotic episode. The deficit may disappear on remission from the acute phase, as described in some studies. A substantial body of research has highlighted the impaired ToM in schizophrenia. There is good empirical evidence that ToM is specifically impaired in schizophrenia and that many psychotic symptoms--for instance, delusions of alien control and persecution, the presence of thought and language disorganization, and other behavioral symptoms--may best be understood in light of a disturbed capacity in patients to relate their own intentions to executing behavior, and to monitor others' intentions. However, it is still under debate how an impaired ToM in schizophrenia is associated with other aspects of cognition, how the impairment fluctuates with acuity or chronicity of the schizophrenic disorder, and if it is a state or trate marker. The paper reviews the current literature and suggests potential implications and future research areas.

  19. Peran Forum Pustakawan dalam Pengembangan Profesionalisme Pustakawan di Lingkungan Universitas Gadjah Mada

    Directory of Open Access Journals (Sweden)

    Desy Natalia Anggorowati

    2017-12-01

    Full Text Available This research discusses the role of Librarian Forum at UGM. The purpose of this paper is to examine  the role of Librarian Forum to develop professionalism and competence for librarians and to understand the inhibiting factors from librarians to actively involve themselves in the Forum. Using a descriptive qualitative approach, the data collection method was literature study and interviews. The result indicated that the role of Librarian Forum in the last 3 period: 2011-2013, 2013-2015 and 2015-2018 has been indicated important to support 4 competencies in SKKNI (Standar Kompetensi Kerja Nasional Indonesia. But of the 60 activities, the core competence of “conducting information literacy activities” showed  the highest. Challenges faced by the members to utilise the Librarian Forum as a professional development arena and competence was the schedule. Another challenges were that, the content of activities didnot match with what the members needed.

  20. Temperament and personal character relationship with symptoms of schizophrenia disorder

    Directory of Open Access Journals (Sweden)

    Abbas Abolghasemi

    2011-09-01

    Full Text Available Background: Knowledge is limited concerning the role of temperament and character factors on schizophrenia. Recent studies suggest that dimensions of temperament and character influence symptoms and functions in schizophrenia. The purpose of this study was to determine the relationship between temperament and character with positive and negative symptoms in patients with schizophrenia.Methods: The research sample consisted of 100 men which were randomly selected from schizophrenia patients with positive and negative symptoms at Razi hospital in Tabriz. Temperament and character inventory and positive and negative symptoms scale were used for data collection. Data was analyzed using t-test and discriminate analyses. Results: The research findings showed that patients with schizophrenia with negative symptoms had higher levels of self– transcendence and harm avoidance. However, patients with schizophrenia with positive symptoms had higher levels of cooperativeness. The results of discriminate analysis showed that explained 37 percent of variance of self– transcendence, harm avoidance and cooperativeness for only function between groups of schizophrenia with positive and negative symptoms. Discriminate function obtained was classified correctly by stepwise method 68.3 percent schizophrenia with positive and negative symptoms.Conclusion: It can be concluded that self– transcendence, harm avoidance and cooperativeness discriminated the patients with schizophrenia with positive and negative symptoms. The study confirmed important implications about intensity of symptomology and early intervention for patients with schizophrenia.

  1. CERN hosts Physics and Society Forum

    CERN Multimedia

    Katarina Anthony

    2012-01-01

    On 28-29 March, CERN hosted the fifth edition of the European Physical Society's “Physics and Society” forum. The forum addresses the role of physicists in general society – be they in education, politics, industry or communication. This year, attendees looked at how physicists have adapted - and can continue to adapt - to work in the economic marketplace.   “The forums began back in 2006, as a special closing event for the 2005 World Year of Physics,” explains Martial Ducloy, former President of the French Physical Society and Chair of the EPS Forum Physics and Society. “We decided to keep the sessions going, as they gave physicists a venue to discuss the non-scientific issues that influence their daily work. As the world's largest international physics laboratory – and the venue for this year's EPS Council – CERN seemed the ideal place to host this year's forum.” The forum ...

  2. [Schizophrenia and modern culture: reasons for insanity].

    Science.gov (United States)

    Pérez-Álvarez, Marino

    2012-02-01

    After pointing out the uncertainty and confusion to which neurobiological research has led schizophrenia, as shown and acknowledged in recent reviews, we offer seven reasons for reconsidering schizophrenia a disorder of the self, rather than of the brain. The first reason starts out conceiving schizophrenia as a disorder of the self, in the perspective of current phenomenology. The second relates the fact of its recent origin (as of 1750) with the particular configuration of the modern self and with the great transformation of the community into a society of individuals (industrialization, urbanization). The third reason emphasizes the affinity between schizophrenia and adolescence, a critical age in the formation of the self, which started to be problematic at the end of the 18th century. The fourth is the better prognosis of schizophrenia in developing countries, in comparison to developed countries, which probably has to do with the process of modernization (which still maintains community structures in less developed countries). The fifth is the high incidence of schizophrenia among immigrants, as a fact to be explained in terms of a socio-evolutionary model. The sixth reason reviews the genetic legend of schizophrenia, and how epigenetics gives protagonism back to the environment. The seventh and last reason refers to the reconsideration of psychological therapy as the possible treatment of choice and not merely an adjunct to medication, as it is known that, for patients, interpersonal chemistry is more important than neurochemistry.

  3. Schizophrenia, vitamin D, and brain development.

    Science.gov (United States)

    Mackay-Sim, Alan; Féron, François; Eyles, Darryl; Burne, Thomas; McGrath, John

    2004-01-01

    Schizophrenia research is invigorated at present by the recent discovery of several plausible candidate susceptibility genes identified from genetic linkage and gene expression studies of brains from persons with schizophrenia. It is a current challenge to reconcile this gathering evidence for specific candidate susceptibility genes with the "neurodevelopmental hypothesis," which posits that schizophrenia arises from gene-environment interactions that disrupt brain development. We make the case here that schizophrenia may result not from numerous genes of small effect, but a few genes of transcriptional regulation acting during brain development. In particular we propose that low vitamin D during brain development interacts with susceptibility genes to alter the trajectory of brain development, probably by epigenetic regulation that alters gene expression throughout adult life. Vitamin D is an attractive "environmental" candidate because it appears to explain several key epidemiological features of schizophrenia. Vitamin D is an attractive "genetic" candidate because its nuclear hormone receptor regulates gene expression and nervous system development. The polygenic quality of schizophrenia, with linkage to many genes of small effect, maybe brought together via this "vitamin D hypothesis." We also discuss the possibility of a broader set of environmental and genetic factors interacting via the nuclear hormone receptors to affect the development of the brain leading to schizophrenia.

  4. Smoking in Schizophrenia: an Updated Review.

    Science.gov (United States)

    Šagud, Marina; Vuksan-Ćusa, Bjanka; Jakšić, Nenad; Mihaljević-Peleš, Alma; Rojnić Kuzman, Martina; Pivac, Nela

    2018-06-01

    Patients with schizophrenia continue to have the highest rate of both smoking and heavy nicotine dependence. The interaction between smoking and schizophrenia is complex. There is evidence of the shared genetic background. Recent preclinical and clinical research has further investigated self-medication hypothesis, given that nicotine might alleviate cortical dysfunction. While prior research indicated some favorable effects of smoking on cognitive performance, particulatly on attention/vigilance, recent studies did not confirm those findings. Lower severity of negative symptoms in smokers was not confirmed across studies. Cigarette smoking decreases clozapine and olanzapine concentrations. There is no consistent evidence of favorable effects of nicotine on symptoms in schizophrenia, but the evidence of detrimental effects of smoking on general health is highly consistent. Smoking cessation should be a priority in patients with schizophrenia.

  5. Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium

    NARCIS (Netherlands)

    Walton, Esther; Hibar, Derrek P.; van Erp, Theo G. M.; Potkin, Steven G.; Roiz-Santiañez, R.; Crespo-Facorro, Benedicto; Suarez-Pinilla, P.; Van Haren, N. E.M.; De Zwarte, S. M.C.; Kahn, R. S.; Cahn, W.; Doan, Nhat Trung; Jorgensen, K. N.; Gurholt, T. P.; Agartz, I.; Andreassen, Ole A.; Westlye, Lars T.; Melle, I.; Berg, A. O.; Morch-Johnsen, L; Færden, A.; Flyckt, L.; Fatouros-Bergman, H.; Jönsson, E. G.; Hashimoto, Ryota; Yamamori, H.; Fukunaga, Masaki; Jahanshad, N.; Rossi, P.; Piras, F.; Banaj, N.; Spalletta, G.; Gur, Raquel E.; Gur, Ruben C.; Hanssen-de Wolf, J.E.; Satterthwaite, Theodore D.; Beard, L. M.; Sommer, I. E.; Koops, S.; Gruber, Oliver; Richter, A.; Krämer, B.; Kelly, Rachel S.; Donohoe, Gary; McDonald, C.; Cannon, Dara M.; Corvin, A S; Gill, M.; Di Giorgio, A.; Bertolino, A.; Lawrie, Stephen M.; Nickson, T.; Whalley, Heather C.; Neilson, E.; Calhoun, Vince D.; Thompson, Paul M.; Turner, Jessica A.; Ehrlich, S.

    2018-01-01

    Background Our understanding of the complex relationship between schizophrenia symptomatology and etiological factors can be improved by studying brain-based correlates of schizophrenia. Research showed that impairments in value processing and executive functioning, which have been associated with

  6. Emotion in Schizophrenia: Where Feeling Meets Thinking.

    Science.gov (United States)

    Kring, Ann M; Caponigro, Janelle M

    2010-08-01

    Our understanding of the nature of emotional difficulties in schizophrenia has been greatly enhanced by translational research over the past two decades. By incorporating methods and theories from affective science, researchers have been able to discover that people with schizophrenia exhibit very few outward displays of emotion but report experiencing strong feelings in the presence of emotionally evocative stimuli or events. Recent behavioral, psychophysiological, and brain imaging research has pointed to the importance of considering the time course of emotion in schizophrenia. This work has shown that people with schizophrenia have the ability to experience emotion in the moment; however, they appear to have difficulties when anticipating future pleasurable experiences, and this perhaps affects their motivation to have such experiences. While advancements in our understanding of emotional experience and expression in individuals with schizophrenia have been made, these developments have led to a new collection of research questions directed at understanding the time course of emotion in schizophrenia, including the role of memory and anticipation in motivated behavior, translating laboratory findings to the development of new assessment tools and new treatments targeting emotional impairments in people with this disorder.

  7. Recent advances in understanding schizophrenia.

    Science.gov (United States)

    Haller, Chiara S; Padmanabhan, Jaya L; Lizano, Paulo; Torous, John; Keshavan, Matcheri

    2014-01-01

    Schizophrenia is a highly disabling disorder whose causes remain to be better understood, and treatments have to be improved. However, several recent advances have been made in diagnosis, etiopathology, and treatment. Whereas reliability of diagnosis has improved with operational criteria, including Diagnostic and Statistical Manual of Mental Disorders, (DSM) Fifth Edition, validity of the disease boundaries remains unclear because of substantive overlaps with other psychotic disorders. Recent emphasis on dimensional approaches and translational bio-behavioral research domain criteria may eventually help move toward a neuroscience-based definition of schizophrenia. The etiology of schizophrenia is now thought to be multifactorial, with multiple small-effect and fewer large-effect susceptibility genes interacting with several environmental factors. These factors may lead to developmentally mediated alterations in neuroplasticity, manifesting in a cascade of neurotransmitter and circuit dysfunctions and impaired connectivity with an onset around early adolescence. Such etiopathological understanding has motivated a renewed search for novel pharmacological as well as psychotherapeutic targets. Addressing the core features of the illness, such as cognitive deficits and negative symptoms, and developing hypothesis-driven early interventions and preventive strategies are high-priority goals for the field. Schizophrenia is a severe, chronic mental disorder and is among the most disabling disorders in all of medicine. It is estimated by the National Institute of Mental Health (NIMH) that 2.4 million people over the age of 18 in the US suffer from schizophrenia. This illness typically begins in adolescence and derails the formative goals of school, family, and work, leading to considerable suffering and disability and reduced life expectancy by about 20 years. Treatment outcomes are variable, and some people are successfully treated and reintegrated (i.e. go back to work

  8. Inhibitory Interneurons, Oxidative Stress, and Schizophrenia

    OpenAIRE

    Sullivan, Elyse M.; O’Donnell, Patricio

    2012-01-01

    Translational studies are becoming more common in schizophrenia research. The past couple of decades witnessed the emergence of novel ideas regarding schizophrenia pathophysiology that originated from both human and animal studies. The findings that glutamate and gamma-aminobutyric acid transmission are affected in the disease led to the hypothesis of altered inhibitory neurotransmission as critical for cognitive deficits and to an exploration of novel therapeutic approaches aimed at restorin...

  9. Forum on stigma, discrimination, and health: policies and research challenges. Introduction Fórum: estigma, discriminação e saúde: desafios políticos e acadêmicos. Introdução

    Directory of Open Access Journals (Sweden)

    Simone Monteiro

    2012-01-01

    Full Text Available This introduction outlines the Forum on stigma, discrimination, and health: policies and research challenges, including four articles and a final commentary. The first article reviews the development of international research on the relationship between discrimination and health. The second analyzes the recent Brazilian research output on AIDS, stigma, and discrimination. The third article addresses conceptual and methodological aspects of the relations between discrimination and health from an epidemiological perspective. The forth examines the process of affirming sexual rights in Brazil, involving the judiciary system, public policies, and the executive and legislative branches of government, among others. The fifth paper presents comments and questions on the contents discussed in the first four articles. The reflections aim to provide conceptual and methodological contributions for research and health policies on stigma and discrimination, given the gaps identified in the international and Brazilian literature.Esta introdução apresenta o Fórum: "estigma, discriminação e saúde: desafios políticos e acadêmicos", com quatro artigos e um comentário final. O primeiro artigo discute o desenvolvimento da pesquisa internacional sobre as interseções entre discriminação e saúde. O segundo analisa a produção acadêmica nacional recente sobre AIDS, estigma e discriminação. O terceiro discute aspectos conceituais e metodológicos das relações entre discriminação interpessoal e agravos de saúde nos estudos epidemiológicos. O quarto examina o processo de afirmação dos direitos sexuais no Brasil que envolve o sistema judiciário, políticas públicas e as esferas executivas e legislativas do Estado, entre outros. O quinto trabalho tece considerações e questionamentos sobre os conteúdos apresentadas nos quatro artigos. As reflexões visam fornecer aportes conceituais e metodológicos para pesquisas e políticas em saúde sobre a

  10. European Stirling forum 2000. Proceedings; Europaeisches Stirling Forum 2000. Tagungsband

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    This document comprises all 42 papers presented at the 'European Stirling Forum 2000', held in Osnabrueck on February 22-24, 2000. Among others, the following subjects were discussed: Thermodynamics, new developments, Stirling engines, free piston heat pumps, flow optimisation of regenerators for Stirling engines, simulation for modelling of flow and heat transfer in the gas cycle of Stirling engines, design and performance, Stirling refrigerators, economic efficiency of biomass Stirling engines, power control of a Stirling CHP system, a Stirling refrigerator for ultralow temperatures in the refrigeration industry. [German] Das vorliegende Dokument enthaelt alle (42) Beitraege der Referenten des 'Europaeischen Stirling Forums 2000', das vom 22. bis 24. Februar 2000 in Osnabrueck stattgefunden hat. Einige der behandelten Themenschwerpunkte im Zusammenhang mit der Stirling-Maschine waren die Thermodynamik, neue Entwicklungen des Kreisprozesses, Heissgasmotoren, Freikolben-Waermepumpe, stroemungstechnische Optimierung von Regeneratoren fuer Stirling-Maschinen, Simulation zur Modellierung der Stroemung und Waermeuebertragung im Gaskreislauf von Stirling-Maschinen, Entwurf und Betriebsverhalten, Stirling-Kaeltemaschine, Wirtschaftlichkeit von Biomasse-Stirlingmotoren, Leistungsregelung eines Stirling-Blockheizkraftwerks, Anwendung eines Stirling-Kuehlers, zum Ultratiefkuehlen in der Kuehlindustrie. (AKF)

  11. [Researching subordinate personality atavism in schizophrenia from the perspective of physical, mental and spiritual healing, and helping the patient to recover].

    Science.gov (United States)

    Hsu, Tien-Sheng

    2007-06-01

    Schizophrenia is not an incurable condition. If we had not understood the operating model of schizophrenia in its spiritual phase, we would not know what its causes were, and there would be no cure for it. The author has studied The Seth Material for more than twenty years. New Age thinking has it that schizophrenia can be redefined as a phenomenon of subordinate personality or secondary personality. This new definition has directly pointed out and solved the core problems of schizophrenia. It has provided a perfect explanation of phenomenology. Also, the etiology of schizophrenia has been built. A guide to diagnosis and the new treatment has been produced. The secondary personality, as described above, prevents the patient from being willing to face and grow with his main personality, and causes him to split from it. A new vision of mind and spirit enables a schizophrenic episode to be seen in fact as a process which forces him to face himself and push him to grow into one and self-heal. According to the symptoms of schizophrenia (auditory hallucinations, thought withdrawal, insertion and interruption, thought broadcasting, somatic hallucinations, delusional perception, external agents), which are the key points of recovery, the author proposes the theory of recorder as a spiritual prescription for healing which has succeeded in helping our patients.

  12. Paranoid schizophrenia versus schizoaffective disorder: Neuropsychological aspects

    Directory of Open Access Journals (Sweden)

    Leposavić Ljubica

    2015-01-01

    Full Text Available Introduction. Neuropsychological aspects of paranoid schizophrenia have still not been examined enough. These disorders are usually not studied separately, but are included in the studies about schizophrenic patients with positive symptoms. Despite the fact that schizophrenia represents a heterogeneous group of mental disorders, usually it is not separated from schizoaffective disorder in neuropsychological researches. Objective. The essence of this research is to evaluate cognitive functioning of patients with paranoid schizophrenia and schizoaffective disorder by applying neuropsychological tests. Methods. The research included 91 subjects, right handed, from 30 to 53 years old, who were classified into three groups: inpatients with paranoid schizophrenia in remission (n=31, inpatients with schizoaffective disorder in remission (n=30 and healthy subjects (n=30. Results. Both groups of patients showed poorer achievements than healthy subjects in most of the applied tests. Patients with schizoaffective disorder showed global loss of intellectual efficiency, executive dysfunction and compromised visual-construction organization. Patients with paranoid schizophrenia expressed partial loss of intellectual efficiency with verbal IQ and executive functions preserved. Conclusion. In the remission phase, patients with paranoid schizophrenia expressed cognitive disorders in moderate degree, but when it comes to patients with schizoaffective disorder, more massive cognitive deficits were registered.

  13. Paranoid Schizophrenia versus Schizoaffective Disorder: Neuropsychological Aspects.

    Science.gov (United States)

    Leposavić, Ljubica; Leposavić, Ivana; Šaula-Marojević, Bijana; Gavrilović, Predrag

    2015-01-01

    Neuropsychological aspects of paranoid schizophrenia have still not been examined enough.These disorders are usually not studied separately, but are included in the studies about schizophrenic patients with positive symptoms. Despite the fact that schizophrenia represents a heterogeneous group of mental disorders, usually it is not separated from schizoaffective disorder in neuropsychological researches. The essence of this research is to evaluate cognitive functioning of patients with paranoid schizophrenia and schizoaffective disorder by applying neuropsychological tests. The research included 91 subjects, right handed, from 30 to 53 years old, who were classified into three groups: inpatients with paranoid schizophrenia in remission (n=31), inpatients with schizoaffective disorder in remission (n=30) and healthy subjects (n=30). Both groups of patients showed poorer achievements than healthy subjects in most of the applied tests. Patients with schizoaffective disorder showed global loss of intellectual efficiency, executive dysfunction and compromised visual-construction organization. Patients with paranoid schizophrenia expressed partial loss of intellectual efficiency with verbal IQ and executive functions preserved. In the remission phase, patients with paranoid schizophrenia expressed cognitive disorders in moderate degree, but when it comes to patients with schizoaffective disorder, more massive cognitive, deficits were registered.

  14. Electroconvulsive therapy for schizophrenia.

    Science.gov (United States)

    Tharyan, P; Adams, C E

    2005-04-18

    that ECT, combined with treatment with antipsychotic drugs, may be considered an option for people with schizophrenia, particularly when rapid global improvement and reduction of symptoms is desired. This is also the case for those with schizophrenia who show limited response to medication alone. Even though this initial beneficial effect may not last beyond the short term, there is no clear evidence to refute its use for people with schizophrenia. The research base for the use of ECT in people with schizophrenia continues to expand, but even after more than five decades of clinical use, there remain many unanswered questions regarding its role in the management of people with schizophrenia.

  15. Environmental Studies of Schizophrenia Through the Prism of Epigenetics

    OpenAIRE

    Oh, Gabriel; Petronis, Arturas

    2008-01-01

    Traditionally, etiological research of schizophrenia has been focused on elucidating predisposing genes and environmental risk factors. While numerous putative environmental hazards have been suggested, inconsistencies and methodological limitations of epidemiological studies have made it difficult to identify even a single exogenous cause of schizophrenia. Furthermore, there is increasing evidence that environmental risk factors may not play as much of a significant role in schizophrenia as ...

  16. The GABA system in schizophrenia: cells, molecules and microcircuitry.

    Science.gov (United States)

    Benes, Francine M

    2015-09-01

    This is an overview of several papers that have been published in the Special Issue of Schizophrenia Research entitled The GABA System in Schizophrenia: Cells, Molecules and Microcircuitry. This issue presents a broad range of original reports and scholarly reviews regarding recent progress in studies of neural circuitry in corticolimbic brain regions in patients with schizophrenia. Copyright © 2015 Elsevier B.V. All rights reserved.

  17. Competition, Regulation and Development Research Forum ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Many developing countries have adopted market-oriented reforms as a part of the globalization and liberalization process. However, due to market distortions, the need to ensure proper access to essential services requires effective regulation. Accordingly, developing countries are legislating or revising their ...

  18. Cambodia Development Research Forum II | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Au Cambodge, le milieu de recherche n'a pas encore fini de se remettre de décennies de bouleversements, notamment de la guerre civile et d'une période de nettoyage ethnique et intellectuel sous les Khmers rouges. Les chercheurs spécialisés en recherche au service du développement demeurent épars et dissociés, ...

  19. Disrupted Olfactory Integration in Schizophrenia: Functional Connectivity Study.

    Science.gov (United States)

    Kiparizoska, Sara; Ikuta, Toshikazu

    2017-09-01

    Evidence for olfactory dysfunction in schizophrenia has been firmly established. However, in the typical understanding of schizophrenia, olfaction is not recognized to contribute to or interact with the illness. Despite the solid presence of olfactory dysfunction in schizophrenia, its relation to the rest of the illness remains largely unclear. Here, we aimed to examine functional connectivity of the olfactory bulb, olfactory tract, and piriform cortices and isolate the network that would account for the altered olfaction in schizophrenia. We examined the functional connectivity of these specific olfactory regions in order to isolate other brain regions associated with olfactory processing in schizophrenia. Using the resting state functional MRI data from the Center for Biomedical Research Excellence in Brain Function and Mental Illness, we compared 84 patients of schizophrenia and 90 individuals without schizophrenia. The schizophrenia group showed disconnectivity between the anterior piriform cortex and the nucleus accumbens, between the posterior piriform cortex and the middle frontal gyrus, and between the olfactory tract and the visual cortices. The current results suggest functional disconnectivity of olfactory regions in schizophrenia, which may account for olfactory dysfunction and disrupted integration with other sensory modalities in schizophrenia. © The Author 2017. Published by Oxford University Press on behalf of CINP.

  20. Does abnormal sleep impair memory consolidation in schizophrenia?

    Directory of Open Access Journals (Sweden)

    Dara S Manoach

    2009-09-01

    Full Text Available Although disturbed sleep is a prominent feature of schizophrenia, its relation to the pathophysiology, signs, and symptoms of schizophrenia remains poorly understood. Sleep disturbances are well known to impair cognition in healthy individuals. Yet, in spite of its ubiquity in schizophrenia, abnormal sleep has generally been overlooked as a potential contributor to cognitive deficits. Amelioration of cognitive deficits is a current priority of the schizophrenia research community, but most efforts to define, characterize, and quantify cognitive deficits focus on cross-sectional measures. While this approach provides a valid snapshot of function, there is now overwhelming evidence that critical aspects of learning and memory consolidation happen offline, both over time and with sleep. Initial memory encoding is followed by a prolonged period of consolidation, integration, and reorganization, that continues over days or even years. Much of this evolution of memories is mediated by sleep. This article briefly reviews (i abnormal sleep in schizophrenia, (ii sleep-dependent memory consolidation in healthy individuals, (iii recent findings of impaired sleep-dependent memory consolidation in schizophrenia, and (iv implications of impaired sleep-dependent memory consolidation in schizophrenia. This literature suggests that abnormal sleep in schizophrenia disrupts attention and impairs sleep-dependent memory consolidation and task automation. We conclude that these sleep-dependent impairments may contribute substantially to generalized cognitive deficits in schizophrenia. Understanding this contribution may open new avenues to ameliorating cognitive dysfunction and thereby improve outcome in schizophrenia.

  1. Musharraf to attend World Economic Forum at Davos

    CERN Multimedia

    2006-01-01

    President Pervez Musharraf will lead Pakistan's delegation to 2006 annual meeting of World Economic Forum (WEF) at Davos, Switzerland, to be held on Jaunary 25-29, it was officially announced. The President during his three-day visit on Januara 25-27 would also be visiting the European Centre for Nuclear Research (CERN), a leading world institute for research in particle physics (1 page)

  2. Development of Trust in an Online Breast Cancer Forum: A Qualitative Study.

    Science.gov (United States)

    Lovatt, Melanie; Bath, Peter A; Ellis, Julie

    2017-05-23

    Online health forums provide peer support for a range of medical conditions including life-threatening and terminal illnesses. Trust is an important component of peer-to-peer support, although relatively little is known about how trust forms within online health forums. The aim of this paper is to examine how trust develops and influences sharing among users of an online breast cancer forum. An interpretive qualitative approach was adopted. Data were collected from forum posts from 135 threads on 9 boards on the UK charity, Breast Cancer Care (BCC). Semistructured interviews were conducted with 14 BCC forum users. Both datasets were analyzed thematically using Braun and Clarke's approach and combined to triangulate analysis. Trust operates in 3 dimensions, structural, relational, and temporal, and these intersect with each other and do not operate in isolation. The structural dimension relates to how the affordances and formal rules of the site affected trust. The relational dimension refers to how trust was necessarily experienced in interactions with other forum users: it emerged within relationships and was a social phenomenon. The temporal dimension relates to how trust changed over time and was influenced by the length of time users spent on the forum. Trust is a process that changes over time and which is influenced by structural features of the forum, as well as informal but collectively understood relational interactions among forum users. The study provides a better understanding of how the intersecting structural, relational, and temporal aspects that support the development of trust facilitate sharing in online environments. These findings will help organizations developing online health forums. ©Melanie Lovatt, Peter A Bath, Julie Ellis. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 23.05.2017.

  3. National Information Infrastructure Education Forum: A summary report

    Energy Technology Data Exchange (ETDEWEB)

    Tonn, B.E.; Oliver, C.E.

    1994-05-01

    The National Information Infrastructure (NII) Education Forum was held on October 6-8, 1993, in Arlington, Virginia. The Forum was sponsored by the Office of Scientific Computing, U.S. Department of Energy (DOE). Its purpose was to discuss technology for K-12 education and what role DOE and its national laboratories could play in developing, disseminating, and using technology for K-12. The Forum brought together over 120 people from across the nation. Participants represented six groups: national laboratories; education research institutions; K-12 teachers and administrators; industry; federal agencies; and other institutions. The Forum consisted of a series of structured presentations from each of these six groups; technology demonstrations; and open, small group discussions. The presentations covered the following: important K-12 education and computing issues, national laboratory capabilities, other federal sector initiatives, and industry perspectives. The demonstration room had over 20 computers networked to the Internet. Workshop participants were shown (1) how to use the Internet to access resources anywhere in the world, (2) state-of-the-art network video teleconferencing technology, (3) multi-media technology, and (4) various other educational software systems.

  4. Alterations of the occipital lobe in schizophrenia.

    Science.gov (United States)

    Tohid, Hassaan; Faizan, Muhammad; Faizan, Uzma

    2015-07-01

    The relationship of the occipital lobe of the brain with schizophrenia is not commonly studied; however, this topic is considered an essential subject matter among clinicians and scientists. We conducted this systematic review to elaborate the relationship in depth. We found that most schizophrenic patients show normal occipital anatomy and physiology, a minority showed dwindled values, and some demonstrated augmented function and structure. The findings are laborious to incorporate within single disease models that present the involvement of the occipital lobe in schizophrenia. Schizophrenia progresses clinically in the mid-twenties and thirties and its prognosis is inadequate. Changes in the volume, the gray matter, and the white matter in the occipital lobe are quite evident; however, the mechanism behind this involvement is not yet fully understood. Therefore, we recommend further research to explore the occipital lobe functions and volumes across the different stages of schizophrenia.

  5. Disruption of Conscious Access in Schizophrenia.

    Science.gov (United States)

    Berkovitch, Lucie; Dehaene, Stanislas; Gaillard, Raphaël

    2017-11-01

    Schizophrenia is a severe and complex psychiatric disorder resulting in delusions, hallucinations, and cognitive impairments. Across a variety of paradigms, an elevated threshold for conscious perception has been repeatedly observed in persons with schizophrenia. Remarkably, even subtle measures of subliminal processing appear to be preserved. We argue here that the dissociation between impaired conscious access and intact unconscious processing may be due to a specific disruption of top-down attentional amplification. This proposal is compatible with the neurophysiological disturbances observed in schizophrenia, including dysconnectivity, abnormal neural oscillations, and glutamatergic and cholinergic dysregulation. Therefore, placing impaired conscious access as a central feature of schizophrenia can help researchers develop a coherent and parsimonious pathophysiological framework of the disease. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Alterations of the occipital lobe in schizophrenia

    Science.gov (United States)

    Tohid, Hassaan; Faizan, Muhammad; Faizan, Uzma

    2015-01-01

    The relationship of the occipital lobe of the brain with schizophrenia is not commonly studied; however, this topic is considered an essential subject matter among clinicians and scientists. We conducted this systematic review to elaborate the relationship in depth. We found that most schizophrenic patients show normal occipital anatomy and physiology, a minority showed dwindled values, and some demonstrated augmented function and structure. The findings are laborious to incorporate within single disease models that present the involvement of the occipital lobe in schizophrenia. Schizophrenia progresses clinically in the mid-twenties and thirties and its prognosis is inadequate. Changes in the volume, the gray matter, and the white matter in the occipital lobe are quite evident; however, the mechanism behind this involvement is not yet fully understood. Therefore, we recommend further research to explore the occipital lobe functions and volumes across the different stages of schizophrenia. PMID:26166588

  7. Exploring rationality in schizophrenia

    DEFF Research Database (Denmark)

    Revsbech, Rasmus; Mortensen, Erik Lykke; Owen, Gareth

    2015-01-01

    Background Empirical studies of rationality (syllogisms) in patients with schizophrenia have obtained different results. One study found that patients reason more logically if the syllogism is presented through an unusual content. Aims To explore syllogism-based rationality in schizophrenia. Meth...... differences became non-significant. Conclusions When taking intelligence and neuropsychological performance into account, patients with schizophrenia and controls perform similarly on syllogism tests of rationality.......Background Empirical studies of rationality (syllogisms) in patients with schizophrenia have obtained different results. One study found that patients reason more logically if the syllogism is presented through an unusual content. Aims To explore syllogism-based rationality in schizophrenia. Method...... Thirty-eight first-admitted patients with schizophrenia and 38 healthy controls solved 29 syllogisms that varied in presentation content (ordinary v. unusual) and validity (valid v. invalid). Statistical tests were made of unadjusted and adjusted group differences in models adjusting for intelligence...

  8. Occipital bending in schizophrenia.

    Science.gov (United States)

    Maller, Jerome J; Anderson, Rodney J; Thomson, Richard H; Daskalakis, Zafiris J; Rosenfeld, Jeffrey V; Fitzgerald, Paul B

    2017-01-01

    To investigate the prevalence of occipital bending (an occipital lobe crossing or twisting across the midline) in subjects with schizophrenia and matched healthy controls. Occipital bending prevalence was investigated in 37 patients with schizophrenia and 44 healthy controls. Ratings showed that prevalence was nearly three times higher among schizophrenia patients (13/37 [35.1%]) than in control subjects (6/44 [13.6%]). Furthermore, those with schizophrenia had greater normalized gray matter volume but less white matter volume and had larger brain-to-cranial ratio. The results suggest that occipital bending is more prevalent among schizophrenia patients than healthy subjects and that schizophrenia patients have different gray matter-white matter proportions. Although the cause and clinical ramifications of occipital bending are unclear, the results infer that occipital bending may be a marker of psychiatric illness.

  9. THE IX EUROPEAN FORUM ON ANTIPHOSPHOLIPID ANTIBODIES. A BRIEF REVIEW

    Directory of Open Access Journals (Sweden)

    Nataliya V Seredavkina

    2014-01-01

    Full Text Available The article presents a brief review of the proceedings of the IX European Forum on antiphospholipid antibodies held in May 2013 in Krakow (Poland. The aim of the Forum is to coordinate multicenter projects focused on antiphospholipid antibodies (aPL, both clinical and fundamental research, based on cooperation between the European countries. The main purpose is to stimulate research into all aspects of aPL, to facilitate the exchange of information between institutions, and to involve many centers in different countries into scientific research on this issue. The issues of standardization of the diagnostic criteria for antiphospholipid syndrome (APS, primarily serological markers (their specificity, sensitivity and correlation with clinical manifestations, as well as non-criterial manifestations of APS, were considered at the meeting. In addition, the therapy problems were discussed.

  10. Beliefs about schizophrenia and its treatment in Kota Kinabalu, Malaysia.

    Science.gov (United States)

    Swami, Viren; Furnham, Adrian; Kannan, Kumaraswami; Sinniah, Dhachayani

    2008-03-01

    Lay beliefs about schizophrenia have been extensively studied in cross-cultural settings, but research on ethnic differences are currently lacking. This study examined beliefs about the manifestations, causes and cures of schizophrenia in a multi-ethnic sample from Malaysia. In this study, 561 Malay, Chinese and Kadazan-Dusun participants rated 72 statements about schizophrenia on a 7-point scale. Results showed that Malaysians tended to favour social-environmental explanations for schizophrenia. There were also ethnic and sex differences in these results. Specifically, Malay participants more strongly agreed that schizophrenia has a social cause, that treatment should affect changes at a societal level, that schizophrenic behaviour is sinful and that mental hospitals do not provide effective treatments. Lay beliefs about schizophrenia may serve different functions for different ethno-cultural groups, which have an influence on help-seeking behaviour.

  11. Comorbidities and risk factors among patients with schizophrenia.

    Science.gov (United States)

    Harrison, Christopher; Charles, Janice; Britt, Helena

    2015-01-01

    General practitioners (GPs) are charged with maintaining a holistic approach to their patients' health. While most patients with schizophrenia attend public mental health services and/or non-government organisations supporting people with mental illness, 88.2% of people with a psychotic illness (the majority being schizophrenia or schizoaffective disorder) had visited a GP in the previous year. For at least 30-40% of people living with schizophrenia in Australia, ongoing management is provided by their GP alone. Moreover, there is evidence that patients with schizophrenia value the help provided by GPs. Patients with schizophrenia have reduced life expectancy. Overseas research (primarily from the UK and US) has found that the poor physical health of patients with schizophrenia can be attributed to a number of factors such as modifiable lifestyle risk factors and side effects of medication, compounded by causes intrinsic to the illness such as mental stress and loss of initiative.

  12. Psychoeducation for schizophrenia

    Science.gov (United States)

    Xia, Jun; Merinder, Lars Bertil; Belgamwar, Madhvi R

    2014-01-01

    .89, NNT 5 CI 4 to 13). Scale-derived data also suggested that psychoeducation promotes better social and global functioning. In the medium term, treating four people with schizophrenia with psychoeducation instead of standard care resulted in one additional person showing a clinical improvement. Evidence suggests that participants receiving psychoeducation are more likely to be satisfied with mental health services (n = 236, RR 0.24 CI 0.12 to 0.50, NNT 5 CI 5 to 8) and have improved quality of life. Authors’ conclusions Psychoeducation does seem to reduce relapse, readmission and encourage medication compliance, as well as reduce the length of hospital stay in these hospital-based studies of limited quality. The true size of effect is likely to be less than demonstrated in this review - but, nevertheless, some sort of psychoeducation could be clinically effective and potentially cost beneficial. It is not difficult to justify better, more applicable, research in this area aimed at fully investigating the effects of this promising approach. Note: the 27 new citations in the awaiting classification section of the review may alter the conclusions of the review once assessed. PMID:21678337

  13. Toxoplasma gondii and schizophrenia

    OpenAIRE

    Mokhtari Mohammadreza; Mokhtari Mojgan

    2006-01-01

    Recent epidemiologic studies indicate that infectious agents may contribute to some cases of schizophrenia. In animals, infection with Toxoplasma gondii can alter behavior and neurotransmitter function. In humans, acute infection with T. gondii can produce psychotic symptoms similar to those displayed by persons with schizophrenia. Since 1953, a total of 19 studies of T. gondii antibodies in persons with schizophrenia and other severe psychiatric disorders and in controls have been reported; ...

  14. Women and schizophrenia

    OpenAIRE

    Thara, R.; Kamath, Shantha

    2015-01-01

    Women's mental health is closely linked to their status in society. This paper outlines the clinical features of women with schizophrenia and highlights the interpersonal and social ramifications on their lives. There is no significant gender difference in the incidence and prevalence of schizophrenia. There is no clear trend in mortality, although suicides seem to be more in women with schizophrenia. In India, women face a lot of problems, especially in relation to marriage, pregnancy, child...

  15. Childhood laterality and adult schizophrenia spectrum disorders: a prospective investigation

    DEFF Research Database (Denmark)

    Schiffman, Jason; Pestle, Sarah; Mednick, Sara

    2005-01-01

    Left or mixed-handedness, footedness, and eye dominance are thought to indicate abnormalities in lateralization related to schizophrenia. Increased left or mixed-dominance in schizophrenia suggests possible hemispheric abnormalities associated with the disorder. A related body of research suggests...... between children who later developed a schizophrenia spectrum disorder (n = 26) and those who did not develop a schizophrenia spectrum disorder (n = 216), among a high-risk and control, longitudinal sample. The rate of left or mixed-footedness, eye dominance, and any anomalous lateralization...

  16. Differences in Neuropsychological Functioning Between Homicidal and Nonviolent Schizophrenia Samples.

    Science.gov (United States)

    Stratton, John; Cobia, Derin J; Reilly, James; Brook, Michael; Hanlon, Robert E

    2018-02-07

    Few studies have compared performance on neurocognitive measures between violent and nonviolent schizophrenia samples. A better understanding of neurocognitive dysfunction in violent individuals with schizophrenia could increase the efficacy of violence reduction strategies and aid in risk assessment and adjudication processes. This study aimed to compare neuropsychological performance between 25 homicide offenders with schizophrenia and 25 nonviolent schizophrenia controls. The groups were matched for age, race, sex, and handedness. Independent t-tests and Mann-Whitney U-tests were used to compare the schizophrenia groups' performance on measures of cognition, including composite scores assessing domain level functioning and individual neuropsychological tests. Results indicated the violent schizophrenia group performed worse on measures of memory and executive functioning, and the Intellectual Functioning composite score, when compared to the nonviolent schizophrenia sample. These findings replicate previous research documenting neuropsychological deficits specific to violent individuals with schizophrenia and support research implicating fronto-limbic dysfunction among violent offenders with schizophrenia. © 2018 American Academy of Forensic Sciences.

  17. PREFACE: Rusnanotech 2010 International Forum on Nanotechnology

    Science.gov (United States)

    Kazaryan, Konstantin

    2011-03-01

    The Rusnanotech 2010 International Forum on Nanotechnology was held from November 1-3, 2010, in Moscow, Russia. It was the third forum organized by RUSNANO (Russian Corporation of Nanotechnologies) since 2008. In March 2011 RUSNANO was established as an open joint-stock company through the reorganization of the state corporation Russian Corporation of Nanotechnologies. RUSNANO's mission is to develop the Russian nanotechnology industry through co-investment in nanotechnology projects with substantial economic potential or social benefit. Within the framework of the Forum Science and Technology Program, presentations on key trends of nanotechnology development were given by foreign and Russian scientists, R&D officers of leading international companies, universities and scientific centers. The science and technology program of the Forum was divided into eight sections as follows (by following hyperlinks you may find each section's program including videos of all oral presentations): Catalysis and Chemical Industry Nanobiotechnology Nanodiagnostics Nanoelectronics Nanomaterials Nanophotonics Nanotechnolgy In The Energy Industry Nanotechnology in Medicine The scientific program of the forum included 115 oral presentations by leading scientists from 15 countries. Among them in the "Nanomaterials" section was the lecture by Dr Konstantin Novoselov, winner of the Nobel Prize in Physics 2010. The poster session consisted of over 500 presentations, 300 of which were presented in the framework of the young scientists' nanotechnology papers competition. This volume of the Journal of Physics: Conference Series includes a selection of 57 submissions. The scientific program committee: Prof Zhores Alferov, AcademicianVice-president of Russian Academy of Sciences, Nobel Prize winner, Russia, Chairman of the Program CommitteeProf Sergey Deev, Corresponding Member of Russian Academy of SciencesHead of the Laboratory of Molecular Immunology, M M Shemyakin and Yu A Ovchinnikov

  18. Are Individuals with Schizophrenia or Schizotypy More Creative? Evidence from Multiple Tests of Creative Potential

    Science.gov (United States)

    Wang, Lixia; Xu, Xiaobo; Wang, Qing; Healey, Grace; Su, Liang; Pang, Weiguo

    2017-01-01

    Schizophrenia and schizotypy have been often associated with above average creativity; however, empirical studies on the relationship between schizophrenia spectrum disorders and enhanced creativity generated inconsistent results. This research investigates if the association between schizophrenia spectrum disorders and creative potential levels…

  19. [Negative symptoms, emotion and cognition in schizophrenia].

    Science.gov (United States)

    Fakra, E; Belzeaux, R; Azorin, J-M; Adida, M

    2015-12-01

    For a long time, treatment of schizophrenia has been essentially focussed on positive symptoms managing. Yet, even if these symptoms are the most noticeable, negative symptoms are more enduring, resistant to pharmacological treatment and associated with a worse prognosis. In the two last decades, attention has shift towards cognitive deficit, as this deficit is most robustly associated to functional outcome. But it appears that the modest improvement in cognition, obtained in schizophrenia through pharmacological treatment or, more purposely, by cognitive enhancement therapy, has only lead to limited amelioration of functional outcome. Authors have claimed that pure cognitive processes, such as those evaluated and trained in lots of these programs, may be too distant from real-life conditions, as the latter are largely based on social interactions. Consequently, the field of social cognition, at the interface of cognition and emotion, has emerged. In a first part of this article we examined the links, in schizophrenia, between negative symptoms, cognition and emotions from a therapeutic standpoint. Nonetheless, investigation of emotion in schizophrenia may also hold relevant premises for understanding the physiopathology of this disorder. In a second part, we propose to illustrate this research by relying on the heuristic value of an elementary marker of social cognition, facial affect recognition. Facial affect recognition has been repeatedly reported to be impaired in schizophrenia and some authors have argued that this deficit could constitute an endophenotype of the illness. We here examined how facial affect processing has been used to explore broader emotion dysfunction in schizophrenia, through behavioural and imaging studies. In particular, fMRI paradigms using facial affect have shown particular patterns of amygdala engagement in schizophrenia, suggesting an intact potential to elicit the limbic system which may however not be advantageous. Finally, we

  20. Cognition in schizophrenia: Past, present, and future

    Directory of Open Access Journals (Sweden)

    Michael F. Green

    2014-03-01

    Full Text Available Schizophrenia Research: Cognition will serve an important function – a place where interests converge and investigators can learn about the recent developments in this area. This new journal will provide rapid dissemination of information to people who will make good use of it. In this initial article, we comment globally on the study of cognition in schizophrenia: how we got here, where we are, and where we are going. The goal of this first article is to place the study of cognition in schizophrenia within a historical and scientific context. In a field as richly textured as ours it is impossible to hit all the important areas, and we hope the reader will forgive our omissions. Phrased in cognitive terms, our limited presentation of the past is a matter of selective memory, the present is a matter of selective attention, and the future is a matter of selective prospection. This broad introduction emphasizes that cognition in schizophrenia provides clues to pathophysiology, treatment, and outcome. In fact, the study of cognitive impairment in schizophrenia has become wholly intertwined with the study of schizophrenia itself.

  1. Altered brain arginine metabolism in schizophrenia.

    Science.gov (United States)

    Liu, P; Jing, Y; Collie, N D; Dean, B; Bilkey, D K; Zhang, H

    2016-08-16

    Previous research implicates altered metabolism of l-arginine, a versatile amino acid with a number of bioactive metabolites, in the pathogenesis of schizophrenia. The present study, for we believe the first time, systematically compared the metabolic profile of l-arginine in the frontal cortex (Brodmann's area 8) obtained post-mortem from schizophrenic individuals and age- and gender-matched non-psychiatric controls (n=20 per group). The enzyme assays revealed no change in total nitric oxide synthase (NOS) activity, but significantly increased arginase activity in the schizophrenia group. Western blot showed reduced endothelial NOS protein expression and increased arginase II protein level in the disease group. High-performance liquid chromatography and liquid chromatography/mass spectrometric assays confirmed significantly reduced levels of γ-aminobutyric acid (GABA), but increased agmatine concentration and glutamate/GABA ratio in the schizophrenia cases. Regression analysis indicated positive correlations between arginase activity and the age of disease onset and between l-ornithine level and the duration of illness. Moreover, cluster analyses revealed that l-arginine and its main metabolites l-citrulline, l-ornithine and agmatine formed distinct groups, which were altered in the schizophrenia group. The present study provides further evidence of altered brain arginine metabolism in schizophrenia, which enhances our understanding of the pathogenesis of schizophrenia and may lead to the future development of novel preventions and/or therapeutics for the disease.

  2. Criterion and construct validity of the CogState Schizophrenia Battery in Japanese patients with schizophrenia.

    Directory of Open Access Journals (Sweden)

    Taisuke Yoshida

    Full Text Available BACKGROUND: The CogState Schizophrenia Battery (CSB, a computerized cognitive battery, covers all the same cognitive domains as the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS Consensus Cognitive Battery but is briefer to conduct. The aim of the present study was to evaluate the criterion and construct validity of the Japanese language version of the CSB (CSB-J in Japanese patients with schizophrenia. METHODOLOGY/PRINCIPAL FINDINGS: Forty Japanese patients with schizophrenia and 40 Japanese healthy controls with matching age, gender, and premorbid intelligence quotient were enrolled. The CSB-J and the Brief Assessment of Cognition in Schizophrenia, Japanese-language version (BACS-J were performed once. The structure of the CSB-J was also evaluated by a factor analysis. Similar to the BACS-J, the CSB-J was sensitive to cognitive impairment in Japanese patients with schizophrenia. Furthermore, there was a significant positive correlation between the CSB-J composite score and the BACS-J composite score. A factor analysis showed a three-factor model consisting of memory, speed, and social cognition factors. CONCLUSIONS/SIGNIFICANCE: This study suggests that the CSB-J is a useful and rapid automatically administered computerized battery for assessing broad cognitive domains in Japanese patients with schizophrenia.

  3. Advice on Life? Online Fan Forums as a Space for Peer-to-Peer Sex and Relationships Education

    Science.gov (United States)

    Masanet, Maria-Jose; Buckingham, David

    2015-01-01

    Previous research has pointed to the potential of entertainment media as a source of informal sex education for young people. New social media may offer additional potential in this respect. In this paper, we consider the pedagogical possibilities and limitations of online fan forums, via a case study of the forums of the controversial British…

  4. California Geothermal Forum: A Path to Increasing Geothermal Development in California

    Energy Technology Data Exchange (ETDEWEB)

    Young, Katherine R. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2017-01-01

    The genesis of this report was a 2016 forum in Sacramento, California, titled 'California Geothermal Forum: A Path to Increasing Geothermal Development in California.' The forum was held at the California Energy Commission's (CEC) headquarters in Sacramento, California with the primary goal being to advance the dialogues for the U.S. Department of Energy's Geothermal Technologies Office (GTO) and CEC technical research and development (R&D) focuses for future consideration. The forum convened a diverse group of stakeholders from government, industry, and research to lay out pathways for new geothermal development in California while remaining consistent with critical Federal and State conservation planning efforts, particularly at the Salton Sea.

  5. Schizophrenia and Crime: How Predictable Are Charges, Convictions and Violence?

    Science.gov (United States)

    Heinrichs, R. Walter; Sam, Eleanor P.

    2012-01-01

    The schizophrenia-crime relationship was studied in 151 research participants meeting DSM-IV criteria for schizophrenia or schizoaffective disorder and with histories positive or negative for criminal charges, convictions and offences involving violence. These crime-related variables were regressed on a block of nine predictors reflecting…

  6. Brain expressed microRNAs implicated in schizophrenia etiology

    DEFF Research Database (Denmark)

    Hansen, Thomas; Olsen, Line; Lindow, Morten

    2007-01-01

    Protein encoding genes have long been the major targets for research in schizophrenia genetics. However, with the identification of regulatory microRNAs (miRNAs) as important in brain development and function, miRNAs genes have emerged as candidates for schizophrenia-associated genetic factors...

  7. Reflections on 'medical tourism' from the 2016 Global Healthcare Policy and Management Forum.

    Science.gov (United States)

    Crooks, Valorie A; Ormond, Meghann; Jin, Ki Nam

    2017-01-01

    In October 2016, the Global Healthcare Policy and Management Forum was held at Yonsei University, Seoul, South Korea. The goal of the forum was to discuss the role of the state in regulating and supporting the development of medical tourism. Forum attendees came from 10 countries. In this short report article, we identify key lessons from the forum that can inform the direction of future scholarly engagement with medical tourism. In so doing, we reference on-going scholarly debates about this global health services practice that have appeared in multiple venues, including this very journal. Key questions for future research emerging from the forum include: who should be meaningfully involved in identifying and defining categories of those travelling across borders for health services and what risks exist if certain voices are underrepresented in such a process; who does and does not 'count' as a medical tourist and what are the implications of such quantitative assessments; why have researchers not been able to address pressing knowledge gaps regarding the health equity impacts of medical tourism; and how do national-level polices and initiatives shape the ways in which medical tourism is unfolding in specific local centres and clinics? This short report as an important time capsule that summarises the current state of medical tourism research knowledge as articulated by the thought leaders in attendance at the forum while also pushing for research growth.

  8. Understanding user intents in online health forums.

    Science.gov (United States)

    Zhang, Thomas; Cho, Jason H D; Zhai, Chengxiang

    2015-07-01

    Online health forums provide a convenient way for patients to obtain medical information and connect with physicians and peers outside of clinical settings. However, large quantities of unstructured and diversified content generated on these forums make it difficult for users to digest and extract useful information. Understanding user intents would enable forums to find and recommend relevant information to users by filtering out threads that do not match particular intents. In this paper, we derive a taxonomy of intents to capture user information needs in online health forums and propose novel pattern-based features for use with a multiclass support vector machine (SVM) classifier to classify original thread posts according to their underlying intents. Since no dataset existed for this task, we employ three annotators to manually label a dataset of 1192 HealthBoards posts spanning four forum topics. Experimental results show that a SVM using pattern-based features is highly capable of identifying user intents in forum posts, reaching a maximum precision of 75%, and that a SVM-based hierarchical classifier using both pattern and word features outperforms its SVM counterpart that uses only word features. Furthermore, comparable classification performance can be achieved by training and testing on posts from different forum topics.

  9. Nordic Nuclear Materials Forum for Generation IV Reactors

    International Nuclear Information System (INIS)

    Anghel, C.; Penttilae, S.

    2010-03-01

    A network for material issues for Generation IV nuclear power has been initiated within the Nordic countries. The objectives of the Generation IV Nordic Nuclear Materials Forum (NOMAGE4) are to put the basis of a sustainable forum for Gen IV issues, especially focussing on fuels, cladding, structural materials and coolant interaction. Other issues include reactor physics, dynamics and diagnostics, core and fuel design. The present report summarizes the work performed during the year 2009. The efforts made include identification of organisations involved in Gen IV issues in the Nordic countries, update of the forum website, http://www.studsvik.se/GenerationIV, and investigation of capabilities for research within the area of Gen IV. Within the NOMAGE4 project a seminar on Generation IV Nuclear Energy Systems has been organized during 15-16th of October 2009. The aim of the seminar was to provide a forum for exchange of information, discussion on future research needs and networking of experts on Generation IV reactor concepts. As an outcome of the NOMAGE4, a few collaboration project proposals have been prepared/planned in 2009. The network was welcomed by the European Commission and was mentioned as an exemplary network with representatives from industries, universities, power companies and research institutes. NOMAGE4 has been invited to participate to the 'European Energy Research Alliance, EERA, workshop for nuclear structural materials' http://www.eera-set.eu/index.php?index=41 as external observers. Future plans include a new Nordic application for continuation of NOMAGE4 network. (author)

  10. Nordic Nuclear Materials Forum for Generation IV Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Anghel, C. (Studsvik Nuclear AB, Nykoeping (Sweden)); Penttilae, S. (Technical Research Centre of Finland, VTT (Finland))

    2010-03-15

    A network for material issues for Generation IV nuclear power has been initiated within the Nordic countries. The objectives of the Generation IV Nordic Nuclear Materials Forum (NOMAGE4) are to put the basis of a sustainable forum for Gen IV issues, especially focussing on fuels, cladding, structural materials and coolant interaction. Other issues include reactor physics, dynamics and diagnostics, core and fuel design. The present report summarizes the work performed during the year 2009. The efforts made include identification of organisations involved in Gen IV issues in the Nordic countries, update of the forum website, http://www.studsvik.se/GenerationIV, and investigation of capabilities for research within the area of Gen IV. Within the NOMAGE4 project a seminar on Generation IV Nuclear Energy Systems has been organized during 15-16th of October 2009. The aim of the seminar was to provide a forum for exchange of information, discussion on future research needs and networking of experts on Generation IV reactor concepts. As an outcome of the NOMAGE4, a few collaboration project proposals have been prepared/planned in 2009. The network was welcomed by the European Commission and was mentioned as an exemplary network with representatives from industries, universities, power companies and research institutes. NOMAGE4 has been invited to participate to the 'European Energy Research Alliance, EERA, workshop for nuclear structural materials' http://www.eera-set.eu/index.php?index=41 as external observers. Future plans include a new Nordic application for continuation of NOMAGE4 network. (author)

  11. Revised associative inference paradigm confirms relational memory impairment in schizophrenia.

    Science.gov (United States)

    Armstrong, Kristan; Williams, Lisa E; Heckers, Stephan

    2012-07-01

    Patients with schizophrenia have widespread cognitive impairments, with selective deficits in relational memory. We previously reported a differential relational memory deficit in schizophrenia using the Associative Inference Paradigm (AIP), a task suggested by the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative to examine relational memory. However, the AIP had limited feasibility for testing in schizophrenia because of high attrition of schizophrenia patients during training. Here we developed and tested a revised version of the AIP to improve feasibility. 30 healthy control and 37 schizophrenia subjects received 3 study-test sessions on 3 sets of paired associates: H-F1 (house paired with face), H-F2 (same house paired with new face), and F3-F4 (two novel faces). After training, subjects were tested on the trained, noninferential Face-Face pairs (F3-F4) and novel, inferential Face-Face pairs (F1-F2), constructed from the faces of the trained House-Face pairs. Schizophrenia patients were significantly more impaired on the inferential F1-F2 pairs than the noninferential F3-F4 pairs, providing evidence for a differential relational memory deficit. Only 8% of schizophrenia patients were excluded from testing because of poor training performance. The revised AIP confirmed the previous finding of a relational memory deficit in a larger and more representative sample of schizophrenia patients.

  12. Use of Online Forums for Perinatal Mental Illness, Stigma, and Disclosure: An Exploratory Model

    OpenAIRE

    Moore, Donna; Drey, Nicholas; Ayers, Susan

    2017-01-01

    BACKGROUND: Perinatal mental illness is a global health concern; however, many women with the illness do not get the treatment they need to recover. Interventions that reduce the stigma around perinatal mental illness have the potential to enable women to disclose their symptoms to health care providers and consequently access treatment. There are many online forums for perinatal mental illness and thousands of women use them. Preliminary research suggests that online forums may promote help-...

  13. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President, Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996 - is seen here visiting the ATLAS experiment. Photo 01: Hubert Curien (left) with Peter Jenni, spokesman for the ATLAS collaboration, in front of the barrel toroid coil casing for the ATLAS detector. Photo 02: Hubert Curien (left) with Peter Jenni in front of the liquid-argon barrel cryostat in the ATLAS assembly hall. Photo 03: Hubert Curien (left) and Peter Jenni in front of the liquid-argon barrel electromagnetic calorimeter in the ATLAS assembly hall. Photo 04: Hubert Curien (centre), Peter Jenni and Wendy Korda in front of a barrel toroid coil casing in the ATLAS assembly hall. Photo 06: Hubert Curien (left) and Peter J...

  14. Schizophrenia and Metacognition

    DEFF Research Database (Denmark)

    Austin, Stephen F.; Mors, Ole; Nordentoft, Merete

    2014-01-01

    tested for relationships between course of illness and levels of specific metacognitions in schizophrenia spectrum disorders. A large cohort of people with first episode psychosis (n = 578) recruited as part the OPUS trial (1998–2000) were tested. Information about course of illness (remitted, episodic...... beliefs may also impact on positive symptoms and course of illness within schizophrenia....

  15. Suisse Romande forum meets at CERN

    CERN Multimedia

    2005-01-01

    The subject of the «Forum des 100» meeting held at CERN on 9 June was «Suisse Romande: Une région en quête de succès» (a region in search of success). Organised by the magazine l'Hebdo and the Rezonance.ch association, the forum was attended by numerous representatives from politics, industry and education and consisted of a day of lectures and debates. Pascal Couchepin, Head of the Swiss Federal Department of Home Affairs, and Luc Ferry, philosopher and former French Education Minister, were among those who took part in the forum.

  16. GABAergic Mechanisms in Schizophrenia

    DEFF Research Database (Denmark)

    de Jonge, Jeroen C; Vinkers, Christiaan H; Hulshoff Pol, Hilleke E

    2017-01-01

    Schizophrenia is a psychiatric disorder characterized by hallucinations, delusions, disorganized thinking, and impairments in cognitive functioning. Evidence from postmortem studies suggests that alterations in cortical γ-aminobutyric acid (GABAergic) neurons contribute to the clinical features...... of schizophrenia. In vivo measurement of brain GABA levels using magnetic resonance spectroscopy (MRS) offers the possibility to provide more insight into the relationship between problems in GABAergic neurotransmission and clinical symptoms of schizophrenia patients. This study reviews and links alterations...... in the GABA system in postmortem studies, animal models, and human studies in schizophrenia. Converging evidence implicates alterations in both presynaptic and postsynaptic components of GABAergic neurotransmission in schizophrenia, and GABA may thus play an important role in the pathophysiology...

  17. Schizophrenia and Suicide

    Directory of Open Access Journals (Sweden)

    Ozlem Cetin

    2011-12-01

    Full Text Available Suicide is one of the major causes of premature death among patients with schizophrenia. Follow-up studies have estimated that 4-5% of these patients die by suicide. Reducing the high rates of suicide in schizophrenia is possible with understanding of predictive risk factors. Various studies have identified risk factors for suicide in schizophrenia patients. Clinical risk factors include previous suicide attempts, comorbid depression, feelings of hopelessness, concept of insight and substance abuse. Biopsychosocial factors, such as a high intelligence quotient and high level of premorbid functioning, have also been associated with an increased risk of suicide in patients with schizophrenia. The risk of suicide is considered to be highest in the early course of illness. Antipsychotic drugs, in particular clozapine and antidepressants may be helpful in reducing the risk of suicide in schizophrenia.

  18. Disordered Self in the Schizophrenia Spectrum

    DEFF Research Database (Denmark)

    Parnas, Josef; Henriksen, Mads Gram

    2014-01-01

    This article explores the phenomenological and empirical rediscovery of anomalous self-experience as a core feature of the schizophrenia spectrum disorders and presents the current status of research in this field. Historically, a disordered self was considered to be a constitutive phenotype...... of schizophrenia. Although the notion of a disordered self has continued to appear occasionally over the years-mainly in the phenomenologically or psychodynamically oriented literature-this notion was usually considered as a theoretical construct rather than as referring to concretely lived anomalous experiences....... Empirical research on the disorders of self-experience in schizophrenia can be traced back to the US-Denmark psychopathological collaboration in the well-known adoption and high-risk studies, which aimed at identifying trait or phenotypic vulnerability features. This research was later followed by clinical...

  19. Potential Value of Genomic Copy Number Variations in Schizophrenia

    Directory of Open Access Journals (Sweden)

    Chuanjun Zhuo

    2017-06-01

    Full Text Available Schizophrenia is a devastating neuropsychiatric disorder affecting approximately 1% of the global population, and the disease has imposed a considerable burden on families and society. Although, the exact cause of schizophrenia remains unknown, several lines of scientific evidence have revealed that genetic variants are strongly correlated with the development and early onset of the disease. In fact, the heritability among patients suffering from schizophrenia is as high as 80%. Genomic copy number variations (CNVs are one of the main forms of genomic variations, ubiquitously occurring in the human genome. An increasing number of studies have shown that CNVs account for population diversity and genetically related diseases, including schizophrenia. The last decade has witnessed rapid advances in the development of novel genomic technologies, which have led to the identification of schizophrenia-associated CNVs, insight into the roles of the affected genes in their intervals in schizophrenia, and successful manipulation of the target CNVs. In this review, we focus on the recent discoveries of important CNVs that are associated with schizophrenia and outline the potential values that the study of CNVs will bring to the areas of schizophrenia research, diagnosis, and therapy. Furthermore, with the help of the novel genetic tool known as the Clustered Regularly Interspaced Short Palindromic Repeats-associated nuclease 9 (CRISPR/Cas9 system, the pathogenic CNVs as genomic defects could be corrected. In conclusion, the recent novel findings of schizophrenia-associated CNVs offer an exciting opportunity for schizophrenia research to decipher the pathological mechanisms underlying the onset and development of schizophrenia as well as to provide potential clinical applications in genetic counseling, diagnosis, and therapy for this complex mental disease.

  20. Clinical Manifestations of Self-disorders in Schizophrenia Spectrum Conditions

    Directory of Open Access Journals (Sweden)

    Henriksen Mads Gram

    2017-09-01

    Full Text Available This article explores the phenomenologically informed, theoretical and empirical research direction on self-disorders in the schizophrenia spectrum conditions. First, we describe the concept of ‘self’ that is operative in the concept of ‘self-disorders’ and we discuss how this self may be disordered or fragile in the schizophrenia spectrum. Second, we offer a detailed psychopathological presentation and discussion of 3 patients with schizophrenia. The vignettes provide paradigmatic examples of self-disorders in schizophrenia. Third, we summarize the main findings in the current empirical research on self-disorders. These findings consistently indicate that self-disorders constitute a crucial, trait phenotype of the schizophrenia spectrum.

  1. 13th Forum for Specification and Design Languages (FDL) conference

    CERN Document Server

    Morawiec, Adam; System Specification and Design Languages : Selected Contributions from FDL 2010

    2012-01-01

    This book brings together a selection of the best papers from the thirteenth edition of the Forum on specification and Design Languages Conference (FDL), which was held in Southampton, UK in September 2010.  FDL is a well established international forum devoted to dissemination of research results, practical experiences and new ideas in the application of specification, design and verification languages to the design, modelling and verification of integrated circuits, complex hardware/software embedded systems, and mixed-technology systems. Covers design verification, automatic synthesis and mechanized debug aids; Includes language-based modeling and design techniques for embedded systems; Covers design, modeling and verification of mixed physical domain and mixed signal systems that include significant analog parts in electrical and non-electrical domains; Includes formal and semi-formal system level design methods for complex embedded systems based on the Unified Modelling Language (UML) and Model Driven E...

  2. The Forum on Stakeholder Confidence celebrates a decade of work

    International Nuclear Information System (INIS)

    Pescatore, C.; Mays, C.; Diaconu, D.

    2010-01-01

    Since its foundation in 2000, the NEA Radioactive Waste Management Committee (RWMC) Forum on Stakeholder Confidence (FSC) has fostered constructive dialogues and interactions with hundreds of interested parties in radioactive waste management, ranging from specialists and academic researchers, national and local politicians to local stakeholders and associations. Many of those partners came to Paris in September 2010 to participate in the colloquium 'Looking Back, Looking Forward in Stakeholder Engagement'. This Ten- year Anniversary Colloquium as well as the FSC's eleventh regular meeting on the following two days were open to all interested parties. This article describes the Forum and the online reports in which learning is shared. It highlights the two major topics discussed at the Colloquium and reviews the joint evaluation made there of FSC achievements. Finally, it points to the directions selected for a new decade of work

  3. How would the gas exporting countries forum influence gas trade?

    International Nuclear Information System (INIS)

    Wagbara, O.N.

    2007-01-01

    The cleanest burning fossil fuel, today, is natural gas. While many businesses have gone global, it has remained an exception. An impending challenge facing the industry, however, is the evolution of a cartel from the 5-year-old Gas Exporting Countries Forum. How would this new organization influence the trade of gas globally? Does its existence imply a threat to the development of gas trade? The paper reviews this fairly new organization within the context of the above questions. It is mainly a comparative study of the body in relation to OPEC's historical, political and economic development. Subsequently, the author proposes probable influence options available to the Forum and the impending consequence of such actions on the market. The outcome of this study calls for further analysis and research on new issues and questions of interest. (author)

  4. How would the gas exporting countries forum influence gas trade?

    International Nuclear Information System (INIS)

    Wagbara, Obindah N.

    2007-01-01

    The cleanest burning fossil fuel, today, is natural gas. While many businesses have gone global, it has remained an exception. An impending challenge facing the industry, however, is the evolution of a cartel from the 5-year-old Gas Exporting Countries Forum. How would this new organization influence the trade of gas globally? Does its existence imply a threat to the development of gas trade? The paper reviews this fairly new organization within the context of the above questions. It is mainly a comparative study of the body in relation to OPEC's historical, political and economic development. Subsequently, the author proposes probable influence options available to the Forum and the impending consequence of such actions on the market. The outcome of this study calls for further analysis and research on new issues and questions of interest

  5. Generation 4 International Forum. 2009 annual report

    International Nuclear Information System (INIS)

    2009-01-01

    This 2009 Annual Report is the third annual report issued by GIF (Generation 4. International Forum). It includes 3 chapters in addition to an introduction plus 4 appendices, as follows. Chapter 2 describes the membership and organization of GIF, the structure of its cooperative research and development arrangements as well as the status of Members' participation in such arrangements. Chapter 3 summarizes GIF research and development plans, activities and achievements during 2009. It highlights the scientific and technical challenges facing the teams developing Generation IV systems and the major milestones towards the development of these systems. It also describes the progress made on the development of methodologies for assessing Generation IV systems with respect to the established goals of GIF. Chapter 4 reviews the cooperation between GIF and other international programs dealing with the development of nuclear energy. Appendix 1 provides an overview on the goals of Generation IV nuclear energy systems and an outline of the main characteristics of the six systems selected for joint development by GIF. Appendix 2 presents the objectives that have been set for the various System Steering Committees and the associated Project Management Boards for the next 5 years. Appendix 3 reproduces the Table of Contents of the Proceedings from the GIF Symposium held in Paris (France) in 2009. Appendix 4 provides a list of abbreviations and acronyms (with the corresponding definitions) which are used in this report or are relevant to GIF activities

  6. Low-level waste forum meeting reports

    International Nuclear Information System (INIS)

    Sternwheeler, W.D.E.

    1992-01-01

    This paper provides highlights from the 1992 winter meeting of the Low Level Radioactive Wastes Forum. Topics of discussion included: legal information; state and compact reports; freedom of information requests; and storage

  7. Titaanide heitlus: Forum Cinemas vs Cinamon

    Index Scriptorium Estoniae

    2009-01-01

    Cinamon Group avab Solarise keskuses uue Cinamoni kinoketti kuuluva kino, mis konkureerib Coca-Cola Plazaga (võrdlev tabel, allikad: Cinamoni turundusjuht Evelyn Laar ja Forum Cinemas' levijuhi asetäitja Timo Diener)

  8. International Ecohealth Forum 2008 | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... the International Forum on Ecosystem Approaches to Human Health (Montreal, ... the International Association of Ecology and Health (IAEH), and a Brazilian ... Nutrition, health policy, and ethics in the age of public-private partnerships.

  9. Low-level waste forum meeting reports

    International Nuclear Information System (INIS)

    1992-01-01

    This paper provides highlights from the summer meeting of the Low Level Radioactive Waste Forum. Topics of discussion included: responsibility for nonfuel component disposal; state experiences in facility licensing; and volume projections

  10. Low-level waste forum meeting reports

    International Nuclear Information System (INIS)

    1992-01-01

    This report provides highlights from the 1992 fall meeting of the Low LEvel Radioactive Waste Forum. Topics included: disposal options after 1992; interregional agreements; management alternatives; policy; and storage

  11. Social functioning and the course of early-onset schizophrenia: five-year follow-up of a psychosocial intervention

    NARCIS (Netherlands)

    Lenior, M. E.; Dingemans, P. M.; Linszen, D. H.; de Haan, L.; Schene, A. H.

    2001-01-01

    BACKGROUND: Schizophrenia implies severe social impairments. Since the treatment of patients with schizophrenia shifted from long-term hospital admissions to community services, research on social functioning has become increasingly important. AIMS: Follow-up assessment of social functioning in

  12. Non-adherence to pharmacological treatment in schizophrenia and schizophrenia spectrum disorders

    DEFF Research Database (Denmark)

    Ljungdalh, P. M.

    2017-01-01

    Background and objectives The primary treatment for schizophrenia and schizophrenia-spectrum disorders is antipsychotic medication. One of the many public health challenges in mental illness, is to identify contributing factors to non-adherence to pharmacological treatment. The objective...... of this study was to perform an updated systematic review of risk factors for non-adherence to pharmacological treatment in schizophrenia in a European and American context. Methods The study was a systematic literature review of studies that included at least two measurements of pharmacological adherence...... of illness, alcohol or drug abuse and unspecified younger age. Conclusions The findings in this systematic literature review are consistent with previous reviews on non-adherence and schizophrenia. It stresses the methodological challenges in psychiatric adherence research and establishes the need for more...

  13. CARICOF - The Caribbean Regional Climate Outlook Forum

    Science.gov (United States)

    Van Meerbeeck, Cedric

    2013-04-01

    Regional Climate Outlook Forums (RCOFs) are viewed as a critical building block in the Global Framework for Climate Services (GFCS) of the World Meteorological Organization (WMO). The GFCS seeks to extend RCOFs to all vulnerable regions of the world such as the Caribbean, of which the entire population is exposed to water- and heat-related natural hazards. An RCOF is initially intended to identify gaps in information and technical capability; facilitate research cooperation and data exchange within and between regions, and improve coordination within the climate forecasting community. A focus is given on variations in climate conditions on a seasonal timescale. In this view, the relevance of a Caribbean RCOF (CARICOF) is the following: while the seasonality of the climate in the Caribbean has been well documented, major gaps in knowledge exist in terms of the drivers in the shifts of amplitude and phase of seasons (as evidenced from the worst region-wide drought period in recent history during 2009-2010). To address those gaps, CARICOF has brought together National Weather Services (NWSs) from 18 territories under the coordination of the Caribbean Institute for Meteorology and Hydrology (CIMH), to produce region-wide, consensus, seasonal climate outlooks since March 2012. These outlooks include tercile rainfall forecasts, sea and air surface temperature forecasts as well as the likely evolution of the drivers of seasonal climate variability in the region, being amongst others the El Niño Southern Oscillation or tropical Atlantic and Caribbean Sea temperatures. Forecasts for both the national-scale forecasts made by the NWSs and CIMH's regional-scale forecast amalgamate output from several forecasting tools. These currently include: (1) statistical models such as Canonical Correlation Analysis run with the Climate Predictability Tool, providing tercile rainfall forecasts at weather station scale; (2) a global outlooks published by the WMO appointed Global Producing

  14. Proceedings of the Science and Community Environmental Knowledge Fund forum

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This paper presented details of a forum which provided partners and stakeholders with an opportunity to see results of recent projects initiated by the Petroleum Technology Alliance Canada's Science and Community Environmental Knowledge Fund. The aim of the forum was to discuss future directions for research and funding. The fund is comprised of 5 knowledge envelopes covering environmental issues relevant to the oil and gas industry. These include ecosystem and cumulative impact management; health and safety; education and technology; and community environmental knowledge. Achievements, trends, challenges and innovations in environmental impact management were reviewed. Current environmental impact management strategies in British Columbia oil and gas industry were discussed along with issues concerning wildlife and footprint minimization in relation to facility operations and reclamation management. Waste and air quality management issues were also discussed. The forum featured 29 presentations that touched on topics such as innovations and opportunities in environmental impact research; Snake-Sahtaneh Boreal caribou habitat use and ecology; wildlife habitat connectivity and conservation of Peace River lowlands; mountain goats and helicopters; water use plan and low flow analysis; cumulative impacts assessment of development on forests and First Nations of northeast BC; geophysical line construction; the application of First Nations traditional knowledge to reclamation strategies in the oil and gas industry; issues concerning construction and standards; the influence of new technologies in environmental impact management; and the environmental aspects of natural gas midstream operations.

  15. The Copenhagen Forum 1996-2016

    DEFF Research Database (Denmark)

    Ry Nielsen, Jens Carl; Raine, John

    2016-01-01

    Purpose: This chapter tells the story of the initiation, development (over two decades) and collective contribution of the Copenhagen Forum since its foundation in 1996. This Forum comprises a grouping of teachers and directors of masters-level public administrative programmes (notably the MPA) f...... the inspiration for this volume, and the individual contributions, derive. It is a context that has been all about a shared fascination with, and collective commitment to, the advancement of learning and development among practicing public managers....

  16. Jobs and Education: A Progress Report and Open Forum

    Science.gov (United States)

    Nero, Anthony V.

    1996-03-01

    session). Diandra L. Leslie-Pelecky (University of Nebraska, Forum on Education newsletter editor) will report on the AAPT/APS Department Chairs Conference held in May on "physics graduate education for diverse career options." Leonard J. Brillson (Xerox Webster Research Center, Chair of the Forum on Industrial and Applied Physics) will discuss FIAP's plans for more effectively connected employers and physicists, as well as other jobs-related initiatives. James K. Freericks (Georgetown University, member of the steering committee for the planned Forum on Careers and Professional Development) will discuss plans of the new Forum.

  17. Omega-3 fatty acids and schizophrenia: evidences and recommendations.

    Science.gov (United States)

    Marano, G; Traversi, G; Nannarelli, C; Mazza, S; Mazza, M

    2013-01-01

    Schizophrenia is a brain disease that represents a not rare condition, in fact the lifetime risk of developing schizophrenia is widely accepted to be around 1 in 100. Schizophrenia clinically manifests with acute episodes which are associated with hallucinations, delirium, behavioral disorders and a variable range of chronic persistent symptoms, which can be debilitating. The causes of schizophrenia are not clearly understood. It seems that genetic factors may produce a vulnerability to schizophrenia, along with environmental factors that contribute in a different way from individual to individual. In this context schizophrenia constitutes the outcome of a complex interaction between multiple genes and environmental risk factors, none of which on its own causes the disorder itself. Antipsychotic medications represent the first line of psychiatric treatment for schizophrenia. But there is a growing body of evidence that omega-3 fatty acids can prevent the disease or at least mitigate the course and symptoms. Probably, an appropriate dietary supplementation can play a partially therapeutic effect, even in more severe patients, improving some behavioral aspects and, mainly, reducing the cognitive deterioration. In this context the role of omega-3 fatty acids as a treatment for schizophrenia will strengthen the thrust of researchers and clinicians to the integrated approach to the prevention and cure of a disease that for more than a century challenging researchers.

  18. Creating an international forum - The success story of the International Forum for Reactor Aging Management (IFRAM)

    International Nuclear Information System (INIS)

    Brenchley, D.L.; Bond, L.J.; Carpenter, C.E.; Hwang, I.S.; Martin, O.; Reister, R.; Shoji, T.; Tilley, R.

    2012-01-01

    As the benefits of extending the safe operating life of nuclear power plants has become more evident, so has the need to increase international cooperation in reactor aging management research. This paper describes how individuals and organizations from Asia, Europe, and North America teamed to create the International Forum for Reactor Aging Management (IFRAM). The mission of IFRAM is to facilitate the appropriate exchange of information among those parties and organizations around the world that are presently, or are planning to, address issues of nuclear power plant (NPP) systems, structures and components aging management. The main purpose of this paper is to describe the steps to success in creating IFRAM. The desired attributes, charter, and operational methods of IFRAM are described and the key contributors for creating IFRAM are identified. (author)

  19. Attention in schizophrenia and in epileptic psychosis

    Directory of Open Access Journals (Sweden)

    I.C.J Kairalla

    2008-01-01

    Full Text Available The adaptive behavior of human beings is usually supported by rapid monitoring of outstanding events in the environment. Some investigators have suggested that a primary attention deficit might trigger symptoms of schizophrenia. In addition, researchers have long discussed the relationship between schizophrenia and the schizophrenia-like psychosis of epilepsy (SLPE. On the basis of these considerations, the objective of the present study was to investigate attention performance of patients with both disorders. Patient age was 18 to 60 years, and all patients had received formal schooling for at least four years. Patients were excluded if they had any systemic disease with neurologic or psychiatric comorbidity, or a history of brain surgery. The computer-assisted TAVIS-2R test was applied to all patients and to a control group to evaluate and discriminate between selective, alternating and sustained attention. The TAVIS-2R test is divided into three parts: one for selective attention (5 min, the second for alternating attention (5 min, and the third for the evaluation of vigilance or sustained attention (10 min. The same computer software was used for statistical analysis of reaction time, omission errors, and commission errors. The sample consisted of 36 patients with schizophrenia, 28 with interictal SLPE, and 47 healthy controls. The results of the selective attention tests for both patient groups were significantly lower than that for controls. The patients with schizophrenia and SLPE performed differently in the alternating and sustained attention tests: patients with SLPE had alternating attention deficits, whereas patients with schizophrenia showed deficits in sustained attention. These quantitative results confirmed the qualitative clinical observations for both patient groups, that is, that patients with schizophrenia had difficulties in focusing attention, whereas those with epilepsy showed perseveration in attention focus.

  20. Cognition-Emotion Dysinteraction in Schizophrenia

    Directory of Open Access Journals (Sweden)

    Alan eAnticevic

    2012-10-01

    Full Text Available Evolving theories of schizophrenia emphasize a ‘disconnection’ in distributed fronto-striatal-limbic neural systems, which may give rise to breakdowns in cognition and emotional function. We discuss these diverse domains of function from the perspective of disrupted neural circuits involved in ‘cold’ cognitive vs. ‘hot’ affective operations and the interplay between these processes. We focus on three research areas that highlight cognition-emotion dysinteractions in schizophrenia: First, we discuss the role of cognitive deficits in the ‘maintenance’ of emotional information. We review recent evidence suggesting that motivational abnormalities in schizophrenia may in part arise due to a disrupted ability to ‘maintain’ affective information over time. Here, dysfunction in a prototypical ‘cold’ cognitive operation may result in ‘affective’ deficits in schizophrenia. Second, we discuss abnormalities in the detection and ascription of salience, manifest as excessive processing of non-emotional stimuli and inappropriate distractibility. We review emerging evidence suggesting deficits in some, but not other, specific emotional processes in schizophrenia – namely an intact ability to perceive emotion ‘in the moment’ but poor prospective valuation of stimuli and heightened reactivity to stimuli that ought to be filtered. Third, we discuss abnormalities in learning mechanisms that may give rise to delusions, the fixed, false and often emotionally charged beliefs that accompany psychosis. We discuss the role of affect in aberrant belief formation, mostly ignored by current theoretical models. Together, we attempt to provide a consilient overview for how breakdowns in neural systems underlying affect and cognition in psychosis interact across symptom domains. We conclude with a brief treatment of the neurobiology of schizophrenia and the need to close our explanatory gap between cellular-level hypotheses and complex

  1. [Theory of mind in schizophrenia spectrum disorders].

    Science.gov (United States)

    Bora, Emre

    2009-01-01

    To review studies that investigated theory of mind (ToM) deficits in schizophrenia spectrum disorders. After a thorough literature search, 71 studies were included in this review. Data regarding the relationship between ToM, and other cognitive skills, symptoms, and the impact of the state of illness were reviewed. ToM instruments used in schizophrenia spectrum disorders have some major psychometric limitations; however, previous research was still able to provide some important findings regarding mentalizing impairments in schizophrenia. While ToM deficits are more pronounced in the acute phase of illness, it seems to persist during periods of remission. There is also evidence of ToM deficits in the healthy relatives of schizophrenics, patients with delusional disorder and bipolar disorder (BD), and individuals with high schizotypy scores. ToM dysfunction might be secondary to other cognitive deficits in patients with schizophrenia that have a good prognosis, asymptomatic schizophrenia, delusional disorder, and BD. Other cognitive deficits do not seem to explain ToM dysfunction in patients with psychosis and severe negative symptoms. These findings support the contribution of impairment in both domain-general and domain-specific mechanisms to ToM deficits in schizophrenia spectrum disorders. ToM deficits may be important for understanding poor social functioning and poor insight in psychotic disorders. While ToM is influenced by state variables, it might be an endophenotype of schizophrenia; however, ToM is likely to be an indicator of other frontal lobe-related endophenotypes. Longitudinal studies conducted with high-risk individuals are particularly important.

  2. The Influence of Forums and Multilevel Governance on the Climate Adaptation Practices of Australian Organizations

    Directory of Open Access Journals (Sweden)

    Lorraine E. Bates

    2013-12-01

    Full Text Available To date, there are few regulations and policies relating to climate change in Australia. Uncertainty about the timing, structure, and potential impact of proposed legislation such as a national carbon abatement scheme, is leading to planning delays across the country. To assist with these policy uncertainties, organizations can embed themselves in multilevel governance frameworks that inform, structure, and facilitate strategic development, planning, and action. As part of these networks, organizational representatives also engage in formal and informal forums, a type of interorganizational relationship, which can include industry task forces, policy development committees, interagency groups, and specific climate change committees. Forums constitute an additional level of governance that influences decision making. The patterns of relationships within these multilevel governance frameworks are examined in this paper, with a focus on the forum level of organizational cooperation. Specifically, we investigate the type of forums operating and their role in supporting organizational responses to climate change. A series of interviews and focus groups were conducted in two study areas, the Swan Canning region of Western Australia and the Hunter / Central Coast region of New South Wales. The results indicate that organizations participate in a diverse range of forums. Further, forums appear to play a key role in the everyday business of organizations by enhancing their ability to plan and address a range of issues, including those associated with climate change. In addition the research highlights some of the barriers and drivers for the development and implementation of climate adaptation practices that emerge from forum discussions. For example, a lack of government guidance in interpreting climate change policy was described as a barrier yet access to the knowledge and expertise of participants was highlighted as a potential driver. The paper

  3. MiRNAs of peripheral blood as the biomarker of schizophrenia.

    Science.gov (United States)

    He, Kuanjun; Guo, Chuang; He, Lin; Shi, Yongyong

    2018-01-01

    The diagnosis of schizophrenia is currently based on the symptoms and bodily signs rather than on the pathological and physiological markers of the patient. In the search for new molecular targeted therapy medicines, and recurrence of early-warning indicators have become the major focus of contemporary research, because they improve diagnostic accuracy. Biomarkers reflect the physiological, physical and biochemical status of the body, and so have extensive applicability and practical significance. The ascertainment of schizophrenia biomarkers will help diagnose, stratify of disease, and treat of schizophrenia patients. The detection of biomarkers from blood has become a promising area of schizophrenia research. Recently, a series of studies revealed that, MiRNAs play an important role in the genesis of schizophrenia, and their abnormal expressions have the potential to be used as biomarkers of schizophrenia. This article presents and summarizes the value of peripheral blood miRNAs with abnormal expression as the biomarker of schizophrenia.

  4. Generation IV international forum 2002 - remarks

    International Nuclear Information System (INIS)

    Abraham, S.

    2002-01-01

    Analyses and forecasts underscore the important role of nuclear power in energy supply in the 21st century. Important aspects in this respect are the conservation of fossil resources, the protection of the world's climate, and the continuity of supply. Present 1st and 2nd generation nuclear power plants ensure an economical and technically mature electricity supply. Advanced systems offering, e.g., higher efficiency of fuel utilization, simplified systems technology, and advanced safety characteristics, can make available additional benefits in using nuclear power. Upon an initiative of the U.S. Department of Energy (DOE), ten countries combine their efforts in developing such reactor concepts in the Generation IV International Forum (GIF). Argentina, Brazil, Canada, France, Japan, South Africa, South Korea, Switzerland, the United Kingdom, and the United States pursue the common objective in GIF to identify suitable nuclear power systems and promote their development up to the envisaged readiness for construction in 2030. Besides technical and economic questions of nuclear power generation, also other aspects must be considered with a view to the future use of nuclear power. The particularly relevant issues, such as the management of radioactive waste, the intensification of research and development, and international cooperation, have been taken up by the Bush administration at an early point in time and have been, or will be, incorporated in practical solutions, as in the case of the Yucca Mountain repository project. (orig.)

  5. 5th Physics and Society Forum - EPS

    CERN Multimedia

    2012-01-01

    The Fifth Physics and Society Forum, organized by the European Physical Society, will take place at CERN from 28 to 29 March 2012. 
The purpose of the meeting is to explore the challenges experienced by physicists who leave their field of study to pursue alternative careers in the market place outside of teaching and university-based research. 
     It is widely recognized that a knowledgeable society is a prerequisite for growth. Value is only created if knowledge can be transformed into know-how and "know-how-to-do". Today it is widely recognized that a society is unable to grow and sustain an advanced science system unless equally advanced production is present. Today production is off-shored to emerging economies in Asia and elsewhere where labour costs are more favourable. European physicists therefore have the choice of being smarter, working harder and working cheaper or moving into other fields. 

 Registration is open until 1st March 2012. Please ...

  6. Proceedings of the ISES Millennium Solar Forum 2000. 1. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Estrada, Claudio A. [ed.

    2000-07-01

    The ISES Millennium Solar Forum 2000 was organized by the Association Nacional de Energia Solar (ANES) of Mexico, and the International Solar Energy Society (ISES), in collaboration with other national and international organizations from 17 to 22 of September, 2000 in Mexico City. The Scientific-Technical Conference forms the core of this forum. This comprises of 167 papers, which were presented orally and form part of the proceedings. The papers represent the results of research and technological development effort in Renewable Energy reported by professionals and students of 22 countries. Of course, a major component is from Mexico and Latin America. Here you will find useful information on the advances in different fields of Renewable Energy. [Spanish] La Asociacion Nacional de Energia Solar A.C. (ANES) y la International Solar Society (ISES), apoyadas por organizaciones nacionales e internacionales, comprometidas con la promocion de las energias renovables organizaron el ISES Millennium Solar Forum 2000, los dias 17 a 22 de septiembre del 2000 en la Ciudad de Mexico. Como parte medular de este foro se organizo la reunion cientifico-tecnica, en donde se presentaron 167 trabajos, la mayoria de los cuales se incluyen en esta memoria. Estos trabajos representan el esfuerzo en investigacion y desarrollo tecnologico de estudiantes y profesionales de mas de 22 paises, la mayoria de Mexico y America Latina. En esta memoria se encuentran los avances mas relevantes en las distintas areas de especializacion de las energias renovables.

  7. Clarification of nuclear risk recognition scheme through dialogue forum

    International Nuclear Information System (INIS)

    Yagi, Ekou; Takahashi, Makoto; Kitamura, Masaharu

    2007-01-01

    The design framework and operational guidelines for conducting repetitive dialogue between public and nuclear engineers are described in this paper. An action research project named repetitive dialogue forum has been conducted in two municipalities where nuclear facilities were sited. The qualitative evaluation by public participants indicated that the public trust in the nuclear experts, known as the crucial factor for meaningful communication, was successfully established through the dialogue forum. In addition, the expert showed a marked psychological change from distrust to trust in public. Through a detailed analysis of the comments of the participants raised during the forums, the nuclear risk recognition scheme of the public was clarified. The constituents of the risk recognition scheme about nuclear facilities were identified as follows. The first is related to the technical risk recognition factor including purely technical risk, organizational elements and regulatory elements. The second is the social risk recognition factor including economical and mental elements. The last is the communication factor including the influence of mass media, difficulty in frank communication in local community etc. It became clear that the information provision activities conducted by the government and the nuclear industry were lack of in-depth understanding of actual information needs in the public. Provision of information contents consistent with our observations is recommended for reestablishment of public trust in expert and for more informative dialogical interactions. (author)

  8. A virtual reality task based on animal research – spatial learning and memory in patients after the first episode of schizophrenia

    Czech Academy of Sciences Publication Activity Database

    Fajnerová, Iveta; Rodriguez, M.; Levčík, David; Konrádová, L.; Mikoláš, P.; Brom, C.; Stuchlík, Aleš; Vlček, Kamil; Horáček, J.

    2014-01-01

    Roč. 8, May 27 (2014), s. 157 ISSN 1662-5153 R&D Projects: GA MZd(CZ) NT13386 Grant - others:GA MZd(CZ) NT14291; GA MZd(CZ) NT13843 Institutional support: RVO:67985823 Keywords : schizophrenia * spatial navigation * learning and memory * virtual reality environment * cognitive deficit * Morris Water Maze (MWM) * psychotic disorders * spatial behavior Subject RIV: FH - Neurology Impact factor: 3.270, year: 2014

  9. 7. heat pump forum. Lectures; 7. Forum Waermepumpe. Vortraege

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    Within the 7th heat pump forum of the German Federal Association for heat pumps e.V. (Berlin, Federal Republic of Germany) between 22nd and 23rd March, 2009, at the Ellington Hotel in Berlin, the following lectures were held: (1) Potentials of the near-surface geothermics in Germany (H. Gassner); (2) Significance of renewable energy sources after the Bundestag election (D. Schuetz); (3) European draft laws in survey: EE regulation, EPBD, EuP (M. Ferber); (4) My personal experiences with heat pumps (G. Nuesslein); (5) European energy policy with relevance to the German heating market (A. Luecke); (6) Do we economize sustainable? - Reactions of companies on the challenge of a sustainable development (C. Berg); (7) Utilize the crisis now - the economic chances of a sustainable energy supply (C. Kemfert); (8) EE regulation: Status quo. Report of the National Renewable Eneregy Action Plan (NREAP) (K. Freier); (9) A legal evaluation of the EE regulation for the energy market (T. Mueller); (10) MAP funding guidelines (U. Sattler); (11) Utilization of renewable energies for heat generation - Experiences of the housing industry (I. Vogler); (12) Combination o the central near-heat supply and decentral drinking water heating in multi-storey new buildings (M.-J. Mucke); (13) Eddicient contracting for heat pumps (A. Kaemmerer); (14) Eco-Design - EU-guidelines and their effects on the heat pump (M. Roffe-Vidal); (15) The quality seal for heat pumps in the Swiss promotion policy (R. Phillips); (16) Enhancement of the significance of the EHPA quality seal in Europe (K. Ochsner); (17) Chances and benefit of export initiatives for the heat pump industry (C. Wittig); (18) The heat pump market in Ireland (P. Murphy); (19) Quantum heat pumps in double capacitors (M. Enzensperger); (20) First CO{sub 2}-free football stadium worldwide thanks to heat pumps (A. Poehlmann); (21) The heat pump in turnkey solid-construction house (C. Schmidt); (22) Instruments of quality requirement and

  10. Childhood laterality and adult schizophrenia spectrum disorders: a prospective investigation

    DEFF Research Database (Denmark)

    Schiffman, Jason; Pestle, Sarah; Mednick, Sara

    2005-01-01

    Left or mixed-handedness, footedness, and eye dominance are thought to indicate abnormalities in lateralization related to schizophrenia. Increased left or mixed-dominance in schizophrenia suggests possible hemispheric abnormalities associated with the disorder. A related body of research suggests...... that some indications of lateralization abnormalities may be evident prior to the onset of schizophrenia, suggesting that disruptions in lateralization are inherent to the developmental course of the disorder. We attempted to replicate and extend upon findings indicating differences in lateralization...... between children who later developed a schizophrenia spectrum disorder (n = 26) and those who did not develop a schizophrenia spectrum disorder (n = 216), among a high-risk and control, longitudinal sample. The rate of left or mixed-footedness, eye dominance, and any anomalous lateralization...

  11. Evaluating lexical characteristics of verbal fluency output in schizophrenia.

    Science.gov (United States)

    Juhasz, Barbara J; Chambers, Destinee; Shesler, Leah W; Haber, Alix; Kurtz, Matthew M

    2012-12-30

    Standardized lexical analysis of verbal output has not been applied to verbal fluency tasks in schizophrenia. Performance of individuals with schizophrenia on both a letter (n=139) and semantic (n=137) fluency task was investigated. The lexical characteristics (word frequency, age-of-acquisition, word length, and semantic typicality) of words produced were evaluated and compared to those produced by a healthy control group matched on age, gender, and Wechsler Adult Intelligence Scale-Third Edition (WAIS-III) vocabulary scores (n=20). Overall, individuals with schizophrenia produced fewer words than healthy controls, replicating past research (see Bokat and Goldberg, 2003). Words produced in the semantic fluency task by individuals with schizophrenia were, on average, earlier acquired and more typical of the category. In contrast, no differences in lexical characteristics emerged in the letter fluency task. The results are informative regarding how individuals with schizophrenia access their mental lexicons during the verbal fluency task. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  12. Further evidence for a deficit in switching attention in schizophrenia.

    Science.gov (United States)

    Smith, G L; Large, M M; Kavanagh, D J; Karayanidis, F; Barrett, N A; Michie, P T; O'Sullivan, B T

    1998-08-01

    In this study, sustained, selective, divided, and switching attention, and reloading of working memory were investigated in schizophrenia by using a newly developed Visual Attention Battery (VAB). Twenty-four outpatients with schizophrenia and 24 control participants were studied using the VAB. Performance on VAB components was correlated with performance of standard tests. Patients with schizophrenia were significantly impaired on VAB tasks that required switching of attention and reloading of working memory but had normal performance on tasks involving sustained attention or attention to multiple stimulus features. Switching attention and reloading of working memory were highly correlated with Trails (B-A) score for patients. The decline in performance on the switching-attention task in patients with schizophrenia met criteria for a differential deficit in switching attention. Future research should examine the neurophysiological basis of the switching deficit and its sensitivity and specificity to schizophrenia.

  13. Distinct conflict resolution deficits related to different facets of Schizophrenia.

    Science.gov (United States)

    Kerns, John G

    2009-11-01

    An important issue in understanding the nature of conflict processing is whether it is a unitary or multidimensional construct. One way to examine this is to study whether people with impaired conflict processing exhibit a general pattern of deficits or whether they exhibit impairments in distinct aspects of conflict processing. One group who might exhibit conflict deficits are people with schizophrenia. Schizophrenia is a heterogeneous disorder, with one way to break down the heterogeneity of schizophrenia is to examine specific symptoms. Previous research has found that specific symptoms of schizophrenia are associated with specific deficits in conflict processing. In particular, disorganization is associated with increased response conflict, alogia is associated with increased retrieval conflict, and anhedonia is associated with increased emotional conflict. Moreover, there is evidence that different types of conflict processing are unassociated with each other. This evidence suggests that conflict processing is a multidimensional construct and that different aspects of schizophrenia are associated with impairments in processing different types of conflict.

  14. Schizophrenia and chromosomal deletions

    Energy Technology Data Exchange (ETDEWEB)

    Lindsay, E.A.; Baldini, A. [Baylor College of Medicine, Houston, TX (United States); Morris, M. A. [Univ. of Geneva School of Medicine, NY (United States)] [and others

    1995-06-01

    Recent genetic linkage analysis studies have suggested the presence of a schizophrenia locus on the chromosomal region 22q11-q13. Schizophrenia has also been frequently observed in patients affected with velo-cardio-facial syndrome (VCFS), a disorder frequently associated with deletions within 22q11.1. It has been hypothesized that psychosis in VCFS may be due to deletion of the catechol-o-methyl transferase gene. Prompted by these observations, we screened for 22q11 deletions in a population of 100 schizophrenics selected from the Maryland Epidemiological Sample. Our results show that there are schizophrenic patients carrying a deletion of 22q11.1 and a mild VCFS phenotype that might remain unrecognized. These findings should encourage a search for a schizophrenia-susceptibility gene within the deleted region and alert those in clinical practice to the possible presence of a mild VCFS phenotype associated with schizophrenia. 9 refs.

  15. Reading Emotions from Body Movement: A Generalized Impairment in Schizophrenia.

    Science.gov (United States)

    Vaskinn, Anja; Sundet, Kjetil; Østefjells, Tiril; Nymo, Katharina; Melle, Ingrid; Ueland, Torill

    2015-01-01

    Body language reading is a social cognitive process with importance for successful maneuvering of social situations. In this study, we investigated body language reading as assessed with human point-light displays in participants with a diagnosis of schizophrenia (n = 84) compared to healthy control participants (n = 84), aiming to answer three questions: (1) whether persons with a diagnosis of schizophrenia have poorer body language reading abilities than healthy persons; (2) whether some emotions are easier to read from body language than others, and if this is the same for individuals with schizophrenia and healthy individuals, and (3) whether there are sex differences in body language reading in participants with schizophrenia and healthy participants. A fourth research aim concerned associations of body language reading with symptoms and functioning in participants with schizophrenia. Scores on the body language reading measure was first standardized using a separate sample of healthy control participants (n = 101). Further results showed that persons with schizophrenia had impaired body language reading ability compared to healthy persons. A significant effect of emotion indicated that some emotions (happiness, neutral) were easier to recognize and this was so for both individuals with schizophrenia and healthy individuals. There were no sex differences for either diagnostic group. Body language reading ability was not associated with symptoms or functioning. In conclusion; schizophrenia was characterized by a global impairment in body language reading that was present for all emotions and across sex.

  16. Reading emotions from body movement: a generalized impairment in schizophrenia

    Directory of Open Access Journals (Sweden)

    Anja eVaskinn

    2016-01-01

    Full Text Available Body language reading is a social cognitive process with importance for successful maneuvering of social situations. In this study, we investigated body language reading as assessed with human point-light displays in participants with a diagnosis of schizophrenia (n = 84 compared to healthy control participants (n = 84, aiming to answer three questions: 1 whether persons with a diagnosis of schizophrenia have poorer body language reading abilities than healthy persons; 2 whether some emotions are easier to read from body language than others, and if this is the same for individuals with schizophrenia and healthy individuals, and 3 whether there are sex differences in body language reading in participants with schizophrenia and healthy participants. A fourth research aim concerned associations of body language reading with symptoms and functioning in participants with schizophrenia. Scores on the body language reading measure was first standardized using a separate sample of healthy control participants (n = 101. Further results showed that persons with schizophrenia had impaired body language reading ability compared to healthy persons. A significant effect of emotion indicated that some emotions (happiness, neutral were easier to recognize and this was so for both individuals with schizophrenia and healthy individuals. There were no sex differences for either diagnostic group. Body language reading ability was not associated with symptoms or functioning. In conclusion; schizophrenia was characterized by a global impairment in body language reading that was present for all emotions and across sex.

  17. Attention to gaze and emotion in schizophrenia.

    Science.gov (United States)

    Schwartz, Barbara L; Vaidya, Chandan J; Howard, James H; Deutsch, Stephen I

    2010-11-01

    Individuals with schizophrenia have difficulty interpreting social and emotional cues such as facial expression, gaze direction, body position, and voice intonation. Nonverbal cues are powerful social signals but are often processed implicitly, outside the focus of attention. The aim of this research was to assess implicit processing of social cues in individuals with schizophrenia. Patients with schizophrenia or schizoaffective disorder and matched controls performed a primary task of word classification with social cues in the background. Participants were asked to classify target words (LEFT/RIGHT) by pressing a key that corresponded to the word, in the context of facial expressions with eye gaze averted to the left or right. Although facial expression and gaze direction were irrelevant to the task, these facial cues influenced word classification performance. Participants were slower to classify target words (e.g., LEFT) that were incongruent to gaze direction (e.g., eyes averted to the right) compared to target words (e.g., LEFT) that were congruent to gaze direction (e.g., eyes averted to the left), but this only occurred for expressions of fear. This pattern did not differ for patients and controls. The results showed that threat-related signals capture the attention of individuals with schizophrenia. These data suggest that implicit processing of eye gaze and fearful expressions is intact in schizophrenia. (c) 2010 APA, all rights reserved

  18. Finding Genes for Schizophrenia

    OpenAIRE

    Åberg, Karolina

    2005-01-01

    Schizophrenia is one of our most common psychiatric diseases. It severely affects all aspects of psychological functions and results in loss of contact with reality. No cure exists and the treatments available today produce only partial relief for disease symptoms. The aim of this work is to better understand the etiology of schizophrenia by identification of candidate genes and gene pathways involved in the development of the disease. In a preliminarily study, the effects of medication and g...

  19. Proceedings of the Second National Science and Technology Forum

    International Nuclear Information System (INIS)

    2005-01-01

    In Zambia, a lot of research work has been carried out in Science and Technology without a matching public awareness of the achievements and potential benefits. It is for this reason the National Science and Technology Council hosted the Second National Science and Technology Forum to publicise and promote broad national prioties in Science and Technology research. Highlights included the presentation of papers on residue effect of partially acidulated phosphate rock,the fluorencenceand absortion of white and dyed cotton fabricsand the intergation of indigenious knowledge and technologies in national development among others

  20. The Human Variome Project (HVP) 2009 Forum "Towards Establishing Standards".

    Science.gov (United States)

    Howard, Heather J; Horaitis, Ourania; Cotton, Richard G H; Vihinen, Mauno; Dalgleish, Raymond; Robinson, Peter; Brookes, Anthony J; Axton, Myles; Hoffmann, Robert; Tuffery-Giraud, Sylvie

    2010-03-01

    The May 2009 Human Variome Project (HVP) Forum "Towards Establishing Standards" was a round table discussion attended by delegates from groups representing international efforts aimed at standardizing several aspects of the HVP: mutation nomenclature, description and annotation, clinical ontology, means to better characterize unclassified variants (UVs), and methods to capture mutations from diagnostic laboratories for broader distribution to the medical genetics research community. Methods for researchers to receive credit for their effort at mutation detection were also discussed. (c) 2010 Wiley-Liss, Inc.

  1. Computational Psychiatry and the Challenge of Schizophrenia

    Science.gov (United States)

    Murray, John D.; Chekroud, Adam M.; Corlett, Philip R.; Yang, Genevieve; Wang, Xiao-Jing; Anticevic, Alan

    2017-01-01

    Abstract Schizophrenia research is plagued by enormous challenges in integrating and analyzing large datasets and difficulties developing formal theories related to the etiology, pathophysiology, and treatment of this disorder. Computational psychiatry provides a path to enhance analyses of these large and complex datasets and to promote the development and refinement of formal models for features of this disorder. This presentation introduces the reader to the notion of computational psychiatry and describes discovery-oriented and theory-driven applications to schizophrenia involving machine learning, reinforcement learning theory, and biophysically-informed neural circuit models. PMID:28338845

  2. Loss aversion in schizophrenia.

    Science.gov (United States)

    Trémeau, Fabien; Brady, Melissa; Saccente, Erica; Moreno, Alexis; Epstein, Henry; Citrome, Leslie; Malaspina, Dolores; Javitt, Daniel

    2008-08-01

    Loss aversion in decision-making refers to a higher sensitivity to losses than to gains. Loss aversion is conceived as an affective interference in cognitive processes such as judgment and decision-making. Loss aversion in non-risky choices has not been studied in schizophrenia. Forty-two individuals with schizophrenia and 42 non-patient control subjects, matched by gender and age, were randomized to two different scenarios (a buying scenario and a selling scenario). Subjects were asked to evaluate the price of a decorated mug. Schizophrenia subjects were re-tested four weeks later with the other scenario. Contrary to non-patient controls, schizophrenia subjects did not show loss aversion. In the schizophrenia group, absence of loss aversion was correlated with age, duration of illness, number of months in State hospitals, and poorer performance in the Wisconsin Card Sorting Test, but not with current psychopathology and two domains of emotional experience. Absence of loss aversion in schizophrenia represents a deficit in the processing of emotional information during decision-making. It can be interpreted as a lack of integration between the emotional and the cognitive systems, or to a more diffuse and de-differentiated impact of emotional information on decision-making. Future studies should bring more clarity to this question.

  3. Aripiprazole for late-life schizophrenia

    Directory of Open Access Journals (Sweden)

    Jeffrey Rado

    2010-08-01

    Full Text Available Jeffrey Rado, Philip G JanicakPsychiatric Clinical Research Center, Rush University Medical Center, Chicago, IL, USAAbstract: Antipsychotics are frequently used in elderly patients to treat a variety of conditions, including schizophrenia. While extensively studied for their impact in younger ­populations, there is comparatively limited evidence about the effectiveness of these agents in older patients. Further complicating this situation are the high co-morbidity rates (both psychiatric and ­medical in the elderly; age-related changes in pharmacokinetics leading to a heightened proclivity for adverse effects; and the potential for multiple, clinically relevant drug interactions. With this background in mind, we review diagnostic and treatment-related issues specific to elderly patients suffering from schizophrenia and other psychotic conditions, focusing on the potential role of aripiprazole.Keywords: aripiprazole, schizophrenia, elderly, dopamine partial antagonist

  4. Anomalies of subjective experience in schizophrenia and psychotic bipolar illness

    DEFF Research Database (Denmark)

    Parnas, J; Handest, P; Saebye, D

    2003-01-01

    OBJECTIVE: Contemporary psychopathology, as a result of behaviourally dominated epistemological stance, downplays anomalies of the patient's subjectivity. This neglect has probably deleterious consequences for research in the causes and the boundaries of the schizophrenia spectrum conditions. The...

  5. From predisposition to psychosis: progression of symptoms in schizophrenia

    DEFF Research Database (Denmark)

    Parnas, Josef

    1999-01-01

    Schizophrenia is increasingly viewed as a neurodevelopmental process caused by an interaction between genetic factors and environmental stressors. Prospective studies and retrospective research using objective data indicate that behavioural deviations can be dated to early infancy and cut across...

  6. Recovery from schizophrenia and the recovery model.

    Science.gov (United States)

    Warner, Richard

    2009-07-01

    The recovery model refers to subjective experiences of optimism, empowerment and interpersonal support, and to a focus on collaborative treatment approaches, finding productive roles for user/consumers, peer support and reducing stigma. The model is influencing service development around the world. This review will assess whether optimism about outcome from serious mental illness and other tenets of the recovery model are borne out by recent research. Remission of symptoms has been precisely defined, but the definition of 'recovery' is a more diffuse concept that includes such factors as being productive and functioning independently. Recent research and a large, earlier body of data suggest that optimism about outcome from schizophrenia is justified. A substantial proportion of people with the illness will recover completely and many more will regain good social functioning. Outcome is better for people in the developing world. Mortality for people with schizophrenia is increasing but is lower in the developing world. Working appears to help people recover from schizophrenia, and recent advances in vocational rehabilitation have been shown to be effective in countries with differing economies and labor markets. A growing body of research supports the concept that empowerment is an important component of the recovery process. Key tenets of the recovery model - optimism about recovery from schizophrenia, the importance of access to employment and the value of empowerment of user/consumers in the recovery process - are supported by the scientific research. Attempts to reduce the internalized stigma of mental illness should enhance the recovery process.

  7. Chaos in schizophrenia associations, reality or metaphor?

    Czech Academy of Sciences Publication Activity Database

    Bob, P.; Šusta, M.; Chládek, Jan; Glaslová, K.; Paluš, Milan

    2009-01-01

    Roč. 73, č. 3 (2009), s. 179-185 ISSN 0167-8760 Institutional research plan: CEZ:AV0Z20650511; CEZ:AV0Z10300504 Keywords : Chaos * Schizophrenia * Associations * Electrodermal activity * Lyapunov exponent Subject RIV: FH - Neurology Impact factor: 3.045, year: 2009

  8. Subtypes of aggression in patients with schizophrenia

    DEFF Research Database (Denmark)

    Bo, Sune; Forth, Adelle; Kongerslev, Mickey

    2013-01-01

    Research has repeatedly demonstrated that schizophrenia has a small but significant association with violence. It is further recognised that a subgroup of people with such links also have personality disorders, but the extent to which type of violence or aggression varies according to subgroup is...

  9. Anxiety and Hysterical Symptoms in Schizophrenia | Scribante ...

    African Journals Online (AJOL)

    The existence of both anxiety and hysterical symptoms have been described in schizophrenic populations. Various explanations exist. The issue of whether such symptoms represent discrete clinical entities or are intrinsic to the schizophrenic process, requires further research. Keywords: Schizophrenia, Anxiety, Hysterical

  10. Schizophrenia: management and family burden | Sebit | Central ...

    African Journals Online (AJOL)

    Schizophrenia: management and family burden. MB Sebit. Abstract. No Abstract. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.4314/cajm.v53i9-12.62618 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians ...

  11. Distress attributed to negative symptoms in schizophrenia

    NARCIS (Netherlands)

    Selten, JP; Wiersma, D; van den Bosch, RJ

    2000-01-01

    The purpose of the study was to examine (1) to which negative symptoms schizophrenia patients attribute distress and (2) whether clinical variables can predict the levels of reported distress. With the help of a research assistant, 86 hospitalized patients completed a self-rating scale for negative

  12. The Diagnosis of Schizophrenia According to Kraepelin

    Directory of Open Access Journals (Sweden)

    António Gamito

    2014-10-01

    Full Text Available Kraepelin's methodology and clinical descriptions are still influential in the XXIst century psychiatry. Concerning schizophrenia, the author questions the internal cohesion and predicitve validity of the actual "phenotypes", returning to Kraepelin's concepts regarding the psychopathology and evolution of the disease. The author suggests that the validation of such concepts could influence research and clinical practice.

  13. Homocysteine metabolism and risk of schizophrenia

    NARCIS (Netherlands)

    Muntjewerff, J.W.

    2006-01-01

    The one-carbon cycle hypothesis initiated research of schizophrenia risk in relation to sensitive markers of aberrant homocysteine metabolism, such as B-vitamin concentrations, plasma total homocysteine (tHcy) concentrations, and genetic determinants. We observed decreased plasma and elevated RBC

  14. [Influence of paternal age in schizophrenia].

    Science.gov (United States)

    Hubert, A; Szöke, A; Leboyer, M; Schürhoff, F

    2011-06-01

    Schizophrenia is an aetiologically heterogeneous syndrome, with a strong genetic component. Despite a reduced fertility in this disorder, its prevalence is maintained and could be explained by de novo genetic mutations. Advanced paternal age (APA) is a major source of new mutations in human beings and could thus be associated with an increased risk of developing schizophrenia in offspring. New mutations related to APA have been implicated as a cause of sporadic cases in several autosomal dominant diseases and also in neurodevelopmental diseases, autism, intellectual disabilities, and social functioning. The aim of the present study was to summarize the results of studies investigating the role of APA, and to discuss some interpretations. All relevant studies were identified through the National Library of Medicine (PubMed(®) database). Keywords used for research were "age" and "schizophrenia" linked to "paternal or father". We have identified and analysed eight cohort studies, five case-control studies, two meta-analyses, and one review concerning different father's mutations potentially transmitted, two studies comparing paternal age at conception between sporadic versus familial cases of schizophrenia. All studies selected have been published between 2000 and 2009. After controlling for several confounding factors including maternal age, the relative risk of schizophrenia increased from 1.84 to 4.62 in offspring of fathers with an older age of fatherhood. Mother's age showed no significant effects after adjusting for paternal age. There was a significant association between paternal age and risk of developing schizophrenia, there was a weaker association with psychosis. The results of these different studies are confirmed by two recent meta-analyses which found an increased risk of schizophrenia in offspring of fathers older than 35 years. Two main hypotheses could explain these results. The first one is based on the presence of new mutations in the

  15. Stylistic accommodation on an internet forum as bonding: Do posters adapt to the style of their peers?

    NARCIS (Netherlands)

    Welbers, K.; de Nooy, W.

    2014-01-01

    Internet forums are theorized to be important social platforms for peer influence. Current research tends to conceptualize peer influence as adoption processes, investigating whether information received from network contacts stimulate the adoption of a product, service, taste, or attitude.

  16. Generation 4 International Forum. 2008 annual report

    International Nuclear Information System (INIS)

    2008-01-01

    This 2008 Annual Report is the second annual report issued by GIF (Generation IV International Forum). It provides an update on the GIF organization, membership, and participation in research and development (R-D) projects for each Generation IV system. It summarizes the milestones for development of each system and progress of the R-D toward their accomplishment. Finally, it includes a brief description of the cooperation between GIF and other international endeavors for the development of nuclear energy. Chapter 2 describes the membership and organization of the GIF, the structure of its cooperative research and development arrangements, and the status of Member participation in those arrangements. Chapter 3 provides a summary of the GIF R-D plans, and its activities and achievements during 2008. It highlights the R-D challenges facing the teams developing Generation IV systems and the major milestones towards the development of these systems. It also describes the progress made regarding the development of methodologies for assessing Generation IV systems with respect to the established goals of GIF. Chapter 4 reviews other major international collaborative projects in the field of nuclear energy and explains how the GIF interacts and cooperates with them. Appendix 1 provides an overview on the goals of Generation IV nuclear energy systems and outlines the main characteristics of the six systems selected for joint development by GIF. The list of abbreviations and acronyms given at the end of the report defines terms used in the various chapters including various nuclear energy systems and international programs referred to in connection with GIF R-D activities. Some bibliographical references are given in order to facilitate access to public information about R-D progress and achievements on specific technical issues for GIF systems

  17. Understanding Autism in Schizophrenia

    Directory of Open Access Journals (Sweden)

    Arnaldo Ballerini

    2012-01-01

    Full Text Available Detachment from external reality, distancing from others, closure into a sort of virtual hermitage, and prevalence of inner fantasies, are the descriptive aspects of autism. However, from an anthropological-phenomenological point of view, in schizophrenia, the autistic mode of life can arise from a person’s being confronted with a pathological crisis in the obviousness of the intersubjective world, essentially a crisis in the intersubjective foundation of human presence. The “condition of possibility” of the autistic way of being is the deficiency of the operation that phenomenology call empathetic-intuitive constitution of the Other, an Other which is the naturalness of evidence of being a subject like me. The theme of the Other, of intersubjectivity, has become so central in the psychopathological analysis of schizophrenic disorders because the modifications of interhuman encounter cannot be seen as the secondary consequences of symptoms but constitute the fundamental disorder of schizophrenic alienation. Revision of the concept of autism from the original definition, centered on the prevalence of inner fantasies, leads to the profound change with the vision of autism as “loss” and “void.” I call attention to possibility of phenomenological research to understand autistic world starting from this “void.”

  18. Understanding autism in schizophrenia.

    Science.gov (United States)

    Ballerini, Arnaldo

    2012-01-01

    Detachment from external reality, distancing from others, closure into a sort of virtual hermitage, and prevalence of inner fantasies, are the descriptive aspects of autism. However, from an anthropological-phenomenological point of view, in schizophrenia, the autistic mode of life can arise from a person's being confronted with a pathological crisis in the obviousness of the intersubjective world, essentially a crisis in the intersubjective foundation of human presence. The "condition of possibility" of the autistic way of being is the deficiency of the operation that phenomenology call empathetic-intuitive constitution of the Other, an Other which is the naturalness of evidence of being a subject like me. The theme of the Other, of intersubjectivity, has become so central in the psychopathological analysis of schizophrenic disorders because the modifications of interhuman encounter cannot be seen as the secondary consequences of symptoms but constitute the fundamental disorder of schizophrenic alienation. Revision of the concept of autism from the original definition, centered on the prevalence of inner fantasies, leads to the profound change with the vision of autism as "loss" and "void." I call attention to possibility of phenomenological research to understand autistic world starting from this "void."

  19. FIAP Forum on Entrepreneurship in Physics

    Science.gov (United States)

    2015-03-01

    With the changes in science as globalization has taken root, the future role of physicists becoming a part of the industrial physics community is more imperative. When 80% of graduating physicists will not be employed in academic positions, and 50% of all jobs for these physicists will be industrial sector, the importance of bringing our next generation of scientists up to speed on industrial applications is becoming much more important with the rapid, world-wide development of technology. FIAP is initiating a forum on entrepreneurship as a major role for the next generation of scientists. As physicists are problem solvers and the entrepreneurial experience is all about problem solving: whether involving technology, building a team, or financing a business. This forum seeks to link successful entrepreneurial physicists with the upcoming generation, through the dissemination of their global expertise and experience. The forum will consist of a panel discussion and then be open to question and answers from the audience.

  20. 3rd Developers@CERN Forum

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    It's about U and I !   The Developers@CERN Forum is an event by developers, for developers, aimed at promoting knowledge and experience sharing. This edition will take place at the IT Amphitheatre, on the 13th, 14th and 15th of February afternoons. It will consist of a series of short presentations and workshops. The topic for this conference will be Frontend & User interfaces. Have you got an idea for a presentation or workshop? Then, tell us about it (deadline on 27th of January). Registration will open in November. Please subscribe to developers-forum-announce@cern.ch mailing list for further information. This event will be made by developers for developers. We are counting on your presence, but also on your contributions! To learn more about the initiative, read the CERN Bulletin article. Organization You can get in touch us at developers-forum-organizers@cern.ch.

  1. AMCP Partnership Forum: Driving Value and Outcomes in Oncology.

    Science.gov (United States)

    2017-05-01

    arrangements. Addressing these challenges could lead to improving cancer treatment. The AMCP Partnership Forum titled "Driving Value and Outcomes in Oncology" and the development of this report were supported by AbbVie, Amgen, Bristol-Myers Squibb, Celgene, Foundation Medicine, IntrinsiQ Specialty Solutions, Janssen Oncology and Johnson and Johnson Health Systems, Eli Lilly and Company, National Pharmaceutical Council, Novartis Pharmaceuticals Corporation, Pharmaceutical Research and Manufacturers of America, Sanofi, Takeda Oncology, and Xcenda.

  2. Neurodevelopmental correlates in schizophrenia

    Directory of Open Access Journals (Sweden)

    Ivković Maja

    2003-01-01

    Full Text Available Contemporary aetiopathogenetic considerations, based on neuro-imaging genetic and developmental neurobiology studies, suggest neurodevelopmental origin of schizophrenia. Several lines of evidence including structural abnormalities on in vivo brain imaging, the excess of prenatal and obstetric complications and the association of congenital and minor physical anomalies with schizophrenia, strongly indicate the neurodevelopmental pathogenesis of schizophrenia. On the other hand, controversial concept of psychotic continuum suggests schizophrenia and depression sharing the same genetic contribution to the pathogenesis. If this would be the case, depression could also be considered as neuro developmental disorder. The aims of the study were to investigate the association between: a pregnancy and birth complications (PBC, and b minor physical anomalies (MPA and schizophrenia or depression. Experimental groups consisted of 60 schizophrenic, 28 major depression patients and 30 healthy controls. All patients were diagnosed according to DSM-IV. Schizophrenic group was divided with regard to PANSS score into positive (n=32 and negative form (n=28 subgroups. PBC information were gathered from maternal recall while MPA were examined by using Waldrop scale for adults. The results showed that negative and positive schizophrenic subgroups had significantly more PBC than depressive group (p<0,05, as well than controls (p<0,001; p<0,05; respectively. There was no significant trend for more PBC in negative than in positive subgroup. All schizophrenic patients had higher rates of MPA than depressives (p<0,05. This trend for more MPA was not significant in comparison with healthy controls. These findings suggest that schizophrenia, especially its negative forms, could be considered as a member of the spectrum of neuro developmental disorders, which does not seem to be the case with depression. PBC and MPA could also be valuable in evaluation of risks for

  3. GreyGuide Forum and Repository

    OpenAIRE

    Biagioni, Stefania; Farace, Dominic

    2014-01-01

    We present the GreyGuide: an online forum and repository of good practice in the field of grey literature. The launch of the GreyGuide Repository took place in December 2013 at the Fifteenth International Conference on Grey Literature. Since then, the acquisition of both proposed and published good practices are underway. The GreyGuide as an online forum is currently in a developmental stage and is influenced by the changes that have taken place in GreyNet's new infrastructure commencing in J...

  4. Major economies Forum on energy and climate

    International Nuclear Information System (INIS)

    2009-01-01

    The Major Economies Forum is intended to facilitate an open dialogue among major developed and developing economies, help generate the political leadership necessary to achieve a successful outcome at the United Nations climatic change conference in Copenhagen, and advance the exploration of concrete initiatives and joint ventures that increase the supply of clean energy while cutting greenhouse gas emissions. The Forum's second preparatory meeting was held in Paris in May 2009, mainly focused on greenhouse gas emissions reduction actions and objectives, the diffusion of clean technologies, the financing of activities for climate protection and adaptation to climatic change impacts

  5. Asthma, corticosteroid use and schizophrenia: A nationwide population-based study in Taiwan.

    Directory of Open Access Journals (Sweden)

    Wei-Chen Wang

    Full Text Available Asthma and corticosteroid use have been implicated as possible risk factors for schizophrenia. The retrospective cohort study herein aimed to investigate the association between asthma, corticosteroid use, and schizophrenia.Longitudinal data (2000 to 2007 from adults with asthma (n = 50,046 and without asthma (n = 50,046 were compared on measures of schizophrenia incidence using Taiwan's National Health Insurance Research Database (NHIRD. Incidence of schizophrenia diagnosis (ICD-9 codes 295.XX between 2000 and 2007 were compared between groups. Competing risk-adjusted Cox regression analyses were conducted, adjusting for sex, age, residence, socioeconomic status, corticosteroid use, outpatient and emergency room visit frequency, Charlson comorbidity index, and total length of hospital stays days for any disorder.Of the 75,069 subjects, 238 received a diagnosis of schizophrenia. The mean (SD follow-up interval for all subjects was 5.8 (2.3 years. After adjusting for potential confounding factors, asthma was associated with significantly greater hazard ratio for incident schizophrenia 1.40 (95% CI = 1.05, 1.87. Additional factors associated with greater incidence of schizophrenia were rural residence, lower economic status, and poor general health. Older age (i.e. ≥65 years was negatively associated with schizophrenia incidence. Corticosteroid use was not associated with increased risk for schizophrenia.Asthma was associated with increased risk for schizophrenia. The results herein suggest that a convergent disturbance in the immune-inflammatory system may contribute to the pathoetiology of asthma and schizophrenia.

  6. [Epigenetics of schizophrenia: a review].

    Science.gov (United States)

    Rivollier, F; Lotersztajn, L; Chaumette, B; Krebs, M-O; Kebir, O

    2014-10-01

    Schizophrenia is a frequent and disabling disease associated with heterogeneous psychiatric phenotypes. It emerges during childhood, adolescence or young adulthood and has dramatic consequences for the affected individuals, causing considerable familial and social burden, as well as increasing health expenses. Although some progress has been made in the understanding of their physiopathology, many questions remain unsolved, and the disease is still poorly understood. The prevailing hypothesis regarding psychotic disorders proposes that a combination of genetic and/or environmental factors, during critical periods of brain development increases the risk for these illnesses. Epigenetic regulations, such as DNA methylation, can mediate gene x environment interactions at the level of the genome and may provide a potential substrate to explain the variability in symptom severity and family heritability. Initially, epigenetics was used to design mitotic and meiotic changes in gene transcription that could not be attributed to genetic mutations. It referred later to changes in the epigenome not transmitted through the germline. Thus, epigenetics refers to a wide range of molecular mechanisms including DNA methylation of cytosine residues in CpG dinucleotides and post-translational histone modifications. These mechanisms alter the way the transcriptional factors bind the DNA, modulating its expression. Prenatal and postnatal environmental factors may affect these epigenetics factors, having responsability in long-term DNA transcription, and influencing the development of psychiatric disorders. The object of this review is to present the state of knowledge in epigenetics of schizophrenia, outlining the most recent findings in the matter. We did so using Pubmed, researching words such as 'epigenetics', 'epigenetic', 'schizophrenia', 'psychosis', 'psychiatric'. This review summarizes evidences mostly for two epigenetic mechanisms: DNA methylation and post

  7. Recognition memory probes affect what is remembered in schizophrenia.

    Science.gov (United States)

    Schwartz, Barbara L; Parker, Elizabeth S; Rosse, Richard B; Deutsch, Stephen I

    2009-05-15

    Cognitive psychology offers tools to localize the memory processes most vulnerable to disruption in schizophrenia and to identify how patients with schizophrenia best remember. In this research, we used the University of Southern California Repeatable Episodic Memory Test (USC-REMT; Parker, E.S., Landau, S.M., Whipple, S.C., Schwartz, B.L., 2004. Aging, recall, and recognition: A study on the sensitivity of the University of Southern California Repeatable Episodic Memory Test (USC-REMT). Journal of Clinical and Experimental Neuropsychology 26(3), 428-440.) to examine how two different recognition memory probes affect memory performance in patients with schizophrenia and matched controls. Patients with schizophrenia studied equivalent word lists and were tested by yes-no recognition and forced-choice recognition following identical encoding and storage conditions. Compared with controls, patients with schizophrenia were particularly impaired when tested by yes-no recognition relative to forced-choice recognition. Patients had greatest deficits on hits in yes-no recognition but did not exhibit elevated false alarms. The data point to the importance of retrieval processes in schizophrenia, and highlight the need for further research on ways to help patients with schizophrenia access what they have learned.

  8. An investigation into the drivers of avolition in schizophrenia.

    Science.gov (United States)

    Suri, Gaurav; Lavaysse, Lindsey M; Young, Gerald; Moodie, Craig; Tersakyan, Alen; Gross, James J; Gard, David E

    2018-03-01

    Over a century of research has documented that avolition is a core symptom in schizophrenia. However, the drivers of avolition remain unclear. Conceptually, there are at least two potential mutually compatible drivers that could cause avolition in schizophrenia. First, people with schizophrenia might have differences in preferences that result in less goal-directed behavior than non-clinical populations (preference-differences). Second, people with schizophrenia might have difficulty translating their preferences into manifest behavior at rates similar to non-clinical populations (psychological-inertia). In the present work, we modified and validated a well-validated paradigm from the motivation/decision making literature to compare levels of preference-differences and psychological-inertia. To measure preference-differences, people with and without schizophrenia choose between a lower-valenced and higher-valenced image. We measured the rate at which the normatively lower-valenced image was preferred. To measure psychological-inertia, both groups were given the opportunity to volitionally switch from a lower-valenced image and view a higher-valenced image. Contrary to expectations, people with schizophrenia did not differ on either preference-differences or psychological-inertia. Statistical analysis revealed that the possibility of a Type II error for even a weak effect was small. The present data suggest new avenues for research investigating mechanisms underlying avolition and clinical interventions targeting avolition in schizophrenia. Copyright © 2018 Elsevier B.V. All rights reserved.

  9. Defending the unabomber: anosognosia in schizophrenia.

    Science.gov (United States)

    Amador, X F; Paul-Odouard, R

    2000-01-01

    The use of recent psychiatric research in the defense of the 'Unabomber' (United States vs. Theodore Kaczynski) is a compelling example of how the gap between research and practice can have profound consequences on the practice of forensic psychiatry, psychology and the judicial process. In this case, educating the lawyers and the court about the research on poor insight in schizophrenia changed the defense strategy and ultimately the course of the trial.

  10. Predicting severity of paranoid schizophrenia

    OpenAIRE

    Kolesnichenko Elena Vladimirovna

    2015-01-01

    Clinical symptoms, course and outcomes of paranoid schizophrenia are polymorphic. 206 cases of paranoid schizophrenia were investigated. Clinical predictors were collected from hospital records and interviews. Quantitative assessment of the severity of schizophrenia as special indexes was used. Schizoid, epileptoid, psychasthenic and conformal accentuation of personality in the premorbid, early onset of psychosis, paranoid and hallucinatory-paranoid variants of onset predicted more expressed ...

  11. [One decade of functional imaging in schizophrenia research. From visualisation of basic information processing steps to molecular-genetic oriented imaging].

    Science.gov (United States)

    Tost, H; Meyer-Lindenberg, A; Ruf, M; Demirakça, T; Grimm, O; Henn, F A; Ende, G

    2005-02-01

    Modern neuroimaging techniques such as magnetic resonance imaging (MRI) and positron emission tomography (PET) have contributed tremendously to our current understanding of psychiatric disorders in the context of functional, biochemical and microstructural alterations of the brain. Since the mid-nineties, functional MRI has provided major insights into the neurobiological correlates of signs and symptoms in schizophrenia. The current paper reviews important fMRI studies of the past decade in the domains of motor, visual, auditory, attentional and working memory function. Special emphasis is given to new methodological approaches, such as the visualisation of medication effects and the functional characterisation of risk genes.

  12. Cognition-emotion dysinteraction in schizophrenia.

    Science.gov (United States)

    Anticevic, Alan; Corlett, Philip R

    2012-01-01

    Evolving theories of schizophrenia emphasize a "disconnection" in distributed fronto-striatal-limbic neural systems, which may give rise to breakdowns in cognition and emotional function. We discuss these diverse domains of function from the perspective of disrupted neural circuits involved in "cold" cognitive vs. "hot" affective operations and the interplay between these processes. We focus on three research areas that highlight cognition-emotion dysinteractions in schizophrenia: First, we discuss the role of cognitive deficits in the "maintenance" of emotional information. We review recent evidence suggesting that motivational abnormalities in schizophrenia may in part arise due to a disrupted ability to "maintain" affective information over time. Here, dysfunction in a prototypical "cold" cognitive operation may result in "affective" deficits in schizophrenia. Second, we discuss abnormalities in the detection and ascription of salience, manifest as excessive processing of non-emotional stimuli and inappropriate distractibility. We review emerging evidence suggesting deficits in some, but not other, specific emotional processes in schizophrenia - namely an intact ability to perceive emotion "in-the-moment" but poor prospective valuation of stimuli and heightened reactivity to stimuli that ought to be filtered. Third, we discuss abnormalities in learning mechanisms that may give rise to delusions, the fixed, false, and often emotionally charged beliefs that accompany psychosis. We highlight the role of affect in aberrant belief formation, mostly ignored by current theoretical models. Together, we attempt to provide a consilient overview for how breakdowns in neural systems underlying affect and cognition in psychosis interact across symptom domains. We conclude with a brief treatment of the neurobiology of schizophrenia and the need to close our explanatory gap between cellular-level hypotheses and complex behavioral symptoms observed in this illness.

  13. Schizophrenia and city life.

    Science.gov (United States)

    Lewis, G; David, A; Andréasson, S; Allebeck, P

    1992-07-18

    Prevalence of schizophrenia and rates of first admission to hospital for this disorder are higher in most modern industrialised cities, and in urban compared with rural areas. The "geographical drift" hypothesis (ie, most schizophrenics tend to drift into city areas because of their illness or its prodrome) has remained largely unchallenged. We have investigated the association between place of upbringing and the incidence of schizophrenia with data from a cohort of 49,191 male Swedish conscripts linked to the Swedish National Register of Psychiatric Care. The incidence of schizophrenia was 1.65 times higher (95% confidence interval 1.19-2.28) among men brought up in cities than in those who had had a rural upbringing. The association persisted despite adjustment for other factors associated with city life such as cannabis use, parental divorce, and family history of psychiatric disorder. This finding cannot be explained by the widely held notion that people with schizophrenia drift into cities at the beginning of their illness. We conclude that undetermined environmental factors found in cities increase the risk of schizophrenia.

  14. Treating schizophrenia during menopause.

    Science.gov (United States)

    Brzezinski, Amnon; Brzezinski-Sinai, Noa A; Seeman, Mary V

    2017-05-01

    The aim of this review is to examine three questions: What are the risks and benefits of treating women with schizophrenia with hormone therapy (HT) at menopause? Should the antipsychotic regimen be changed at menopause? Do early- and late-onset women with schizophrenia respond differently to HT at menopause? MEDLINE databases for the years 1990 to 2016 were searched using the following interactive terms: schizophrenia, gender, menopause, estrogen, and hormones. The selected articles (62 out of 800 abstracts) were chosen on the basis of their applicability to the objectives of this targeted narrative review. HT during the perimenopause in women with schizophrenia ameliorates psychotic and cognitive symptoms, and may also help affective symptoms. Vasomotor, genitourinary, and sleep symptoms are also reduced. Depending on the woman's age and personal risk factors and antipsychotic side effects, the risk of breast cancer and cardiovascular disease may be increased. Antipsychotic types and doses may need to be adjusted at menopause, as may be the mode of administration. Both HT and changes in antipsychotic management should be considered for women with schizophrenia at menopause. The question about differences in response between early- and late-onset women cannot yet be answered.

  15. Use of Online Forums for Perinatal Mental Illness, Stigma, and Disclosure: An Exploratory Model.

    Science.gov (United States)

    Moore, Donna; Drey, Nicholas; Ayers, Susan

    2017-02-20

    Perinatal mental illness is a global health concern; however, many women with the illness do not get the treatment they need to recover. Interventions that reduce the stigma around perinatal mental illness have the potential to enable women to disclose their symptoms to health care providers and consequently access treatment. There are many online forums for perinatal mental illness and thousands of women use them. Preliminary research suggests that online forums may promote help-seeking behavior, potentially because they have a role in challenging stigma. This study draws from these findings and theoretical concepts to present a model of forum use, stigma, and disclosure. This study tested a model that measured the mediating role of stigma between online forum use and disclosure of affective symptoms to health care providers. A Web-based survey of 200 women who were pregnant or had a child younger than 5 years and considered themselves to be experiencing psychological distress was conducted. Women were recruited through social media and questions measured forum usage, perinatal mental illness stigma, disclosure to health care providers, depression and anxiety symptoms, barriers to disclosure, and demographic information. There was a significant positive indirect effect of length of forum use on disclosure of symptoms through internal stigma, b=0.40, bias-corrected and accelerated (BCa) 95% CI 0.13-0.85. Long-term forum users reported higher levels of internal stigma, and higher internal stigma was associated with disclosure of symptoms to health care providers when controlling for symptoms of depression and anxiety. Internal stigma mediates the relationship between length of forum use and disclosure to health care providers. Findings suggest that forums have the potential to enable women to recognize and reveal their internal stigma, which may in turn lead to greater disclosure of symptoms to health care providers. Clinicians could refer clients to trustworthy and

  16. Forum: Communication Activism Pedagogy. A Call for an Ethic of Transformation in Communication Activism Education

    Science.gov (United States)

    Artz, Lee

    2017-01-01

    Lawrence Frey and David Palmer present a provocative call for communication education and research that is urgent and opportune in this forum's stimulus essay, "Communication Activism Pedagogy and Research: Communication Education Scholarship to Promote Social Justice." The call is urgent because the global human condition--including…

  17. Cognitive Presence in Virtual Collaborative Learning: Assessing and Improving Critical Thinking in Online Discussion Forums

    Science.gov (United States)

    Beckmann, Jennifer; Weber, Peter

    2015-01-01

    The paper introduces a virtual collaborative learning setting called "Net Economy," which we established as part of an international learning network of currently seven universities. Using the Community of Inquiry framework as guidance and Canonical Action Research (CAR) as the chosen research design, the discussion forum of the online…

  18. Next-generation sequencing in schizophrenia and other neuropsychiatric disorders.

    Science.gov (United States)

    Schreiber, Matthew; Dorschner, Michael; Tsuang, Debby

    2013-10-01

    Schizophrenia is a debilitating lifelong illness that lacks a cure and poses a worldwide public health burden. The disease is characterized by a heterogeneous clinical and genetic presentation that complicates research efforts to identify causative genetic variations. This review examines the potential of current findings in schizophrenia and in other related neuropsychiatric disorders for application in next-generation technologies, particularly whole-exome sequencing (WES) and whole-genome sequencing (WGS). These approaches may lead to the discovery of underlying genetic factors for schizophrenia and may thereby identify and target novel therapeutic targets for this devastating disorder. © 2013 Wiley Periodicals, Inc.

  19. Imaging the glutamatergic system in vivo - relevance to schizophrenia

    Energy Technology Data Exchange (ETDEWEB)

    Bressan, R.A.; Pilowsky, L.S. [Inst. of Psychiatry, London (United Kingdom); Inst. of Nuclear Medicine, University College of London Medical School (United Kingdom)

    2000-11-01

    Schizophrenia is a devastating psychiatric illness. Its pathophysiology is not fully clarified. Animal data, in vitro and indirect in vivo imaging support glutamatergic N-methyl-D-aspartate (NMDA) receptor hypofunction in the disorder. A lack of suitable ligands has obstructed direct evaluation of the NMDA receptor hypofunction hypothesis of schizophrenia. Many research groups are working towards developing appropriate single-photon emission tomography and positron emission tomography ligands for the NMDA receptor. This paper briefly presents evidence for links between glutamatergic system dysfunction and schizophrenia. It reviews the radioligands to evaluate glutamatergic receptors in vivo and discusses issues in developing novel ligands for the glutamatergic system. (orig.)

  20. Imaging the glutamatergic system in vivo - relevance to schizophrenia

    International Nuclear Information System (INIS)

    Bressan, R.A.; Pilowsky, L.S.

    2000-01-01

    Schizophrenia is a devastating psychiatric illness. Its pathophysiology is not fully clarified. Animal data, in vitro and indirect in vivo imaging support glutamatergic N-methyl-D-aspartate (NMDA) receptor hypofunction in the disorder. A lack of suitable ligands has obstructed direct evaluation of the NMDA receptor hypofunction hypothesis of schizophrenia. Many research groups are working towards developing appropriate single-photon emission tomography and positron emission tomography ligands for the NMDA receptor. This paper briefly presents evidence for links between glutamatergic system dysfunction and schizophrenia. It reviews the radioligands to evaluate glutamatergic receptors in vivo and discusses issues in developing novel ligands for the glutamatergic system. (orig.)

  1. Anomalies of subjective experience in schizophrenia and psychotic bipolar illness

    DEFF Research Database (Denmark)

    Parnas, J; Handest, P; Saebye, D

    2003-01-01

    OBJECTIVE: Contemporary psychopathology, as a result of behaviourally dominated epistemological stance, downplays anomalies of the patient's subjectivity. This neglect has probably deleterious consequences for research in the causes and the boundaries of the schizophrenia spectrum conditions....... The purpose of this study is to explore frequency of qualitative, not-yet-psychotic, anomalies of subjective experience in patients with residual schizophrenia and psychotic bipolar illness in remission. METHOD: The patients were examined with the Danish version of the Bonn Scale for the Assessment of Basic...... differential diagnosis and therefore potentially useful in the preonset detection of the schizophrenia spectrum illness....

  2. Generating Benefits and Negotiating Tensions through an International Doctoral Forum: A Sociological Analysis

    Directory of Open Access Journals (Sweden)

    Guanglun Michael Mu

    2016-02-01

    Full Text Available Workshops and seminars are widely-used forms of doctoral training. However, research with a particular focus on these forms of doctoral training is sporadic in the literature. There is little, if any, such research concerning the international context and participants’ own voices. Mindful of these lacunae in the literature, we write the current paper as a group of participants in one of a series of doctoral forums co-organised annually by Beijing Normal University, China and Queensland University of Technology, Australia. The paper voices our own experiences of participation in the doctoral forum. Data were drawn from reflections, journals, and group discussions of all 12 student and academic participants. These qualitative data were organised and analysed through Bourdieu’s notions of capital and field. Findings indicate that the doctoral forum created enabling and challenging social fields where participants accrued and exchanged various forms of capital and negotiated transient and complex power relations. In this respect, the sociological framework used provides a distinctive theoretical tool to conceptualise and analyse the benefits and tensions of participation in the doctoral forum. Knowledge built and lessons learned through our paper will provide implications and recommendations for future planning of, and participation in, the doctoral forum series and similar activities elsewhere.

  3. Epidemic model for information diffusion in web forums: experiments in marketing exchange and political dialog.

    Science.gov (United States)

    Woo, Jiyoung; Chen, Hsinchun

    2016-01-01

    As social media has become more prevalent, its influence on business, politics, and society has become significant. Due to easy access and interaction between large numbers of users, information diffuses in an epidemic style on the web. Understanding the mechanisms of information diffusion through these new publication methods is important for political and marketing purposes. Among social media, web forums, where people in online communities disseminate and receive information, provide a good environment for examining information diffusion. In this paper, we model topic diffusion in web forums using the epidemiology model, the susceptible-infected-recovered (SIR) model, frequently used in previous research to analyze both disease outbreaks and knowledge diffusion. The model was evaluated on a large longitudinal dataset from the web forum of a major retail company and from a general political discussion forum. The fitting results showed that the SIR model is a plausible model to describe the diffusion process of a topic. This research shows that epidemic models can expand their application areas to topic discussion on the web, particularly social media such as web forums.

  4. Low-level waste forum meeting reports

    International Nuclear Information System (INIS)

    1991-01-01

    This report contains highlights from the 1991 fall meeting of the Low Level Radioactive Waste Forum. Topics included legal updates; US NRC updates; US EPA updates; mixed waste issues; financial assistance for waste disposal facilities; and a legislative and policy report

  5. Low-level waste forum meeting reports

    International Nuclear Information System (INIS)

    1993-01-01

    This paper provides the results of the winter meeting of the Low Level Radioactive Waste Forum. Discussions were held on the following topics: new developments in states and compacts; adjudicatory hearings; information exchange on siting processes, storage surcharge rebates; disposal after 1992; interregional access agreements; and future tracking and management issues

  6. Proceedings of a national food irradiation forum

    International Nuclear Information System (INIS)

    Van Noort, G.

    1989-01-01

    The proceedings of a national food irradiation forum are presented. The status of food radurization in South Africa is discussed in detail. Consumer attitudes to radurization are also looked at and the statutory control of food irradiation in South Africa is described

  7. Low-level waste forum meeting reports

    International Nuclear Information System (INIS)

    1992-01-01

    This paper provides highlights from the spring meeting of the Low Level Radioactive Waste Forum. Topics of discussion included: state and compact reports; New York's challenge to the constitutionality of the Low-Level Radioactive Waste Amendments Act of 1985; DOE technical assistance for 1993; interregional import/export agreements; Department of Transportation requirements; superfund liability; nonfuel bearing components; NRC residual radioactivity criteria

  8. The environmental communication forum | Goetz | Southern African ...

    African Journals Online (AJOL)

    The establishment, Modus operandi and aims of the Environmental Communicators Forum in the greater Durban area is described. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · Creative Commons License This work is licensed under a Creative ...

  9. Low-level waste forum meeting reports

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-12-31

    This paper provides highlights from the October 1990 meeting of the Low Level Radioactive Waste Forum. Topics of discussion included: a special session on liability and financial assurance needs; proposal to dispose of mixed waste at federal facilities; state plans for interim storage; and hazardous materials legislation.

  10. ITU World Youth Forum visits CERN

    CERN Multimedia

    2009-01-01

    About 250 students selected by the International Telecommunication Union (ITU) to participate in the 2009 Youth Forum made CERN a primary destination for this year’s World Youth Forum event. The 250 students participating in the 2009 Youth Forum attend a presentation in the Globe of Science and Innovation.On Tuesday 6 October, the group visited several sites including the Microcosm exhibition and the ATLAS cavern to get a glimpse of what CERN does and the exciting science that is studied here. Since 2001 and every three years, the ITU World Forum brings together young men and women, aged 18-23, to learn about new technologies and the world around them. This year’s group included participants from one hundred and twenty-five different countries. This was the first time that the event involved a visit to CERN. When asked why CERN was a destination, Pascal Biner, organizer of the visit for ITU, explained that CERN was a necessary stop given the Forum’s base in Gen...

  11. CERN Apps meet in a forum

    CERN Multimedia

    Antonella Del Rosso

    2013-01-01

    In the fast-evolving world of mobile apps, creativity and usability are key words. For the time being, the number of CERN apps is quite limited but the situation could quickly change. An information-sharing forum set up by the IT Department is a starting point to channel your creativity with the help of experts, best practices and useful guidelines.   The CAPPS (CERN Apps) Forum was set up about a year ago. Its members come from various departments and meet every two or three months to update each other on the apps that are in preparation, share the latest news on the available software, discuss best practices and so on. “The Forum is open to anybody wanting to develop apps at CERN,” explains David Foster, Deputy Department Head and initiator of the CAPPS Forum. “Developers, communication experts and IT infrastructure experts meet and discuss various topics, from branding-related issues to coding and implementation solutions. The aim is to go forward in a coherent way...

  12. Authorship Analysis on Dark Marketplace Forums

    NARCIS (Netherlands)

    Spitters, M.; Klaver, F.; Koot, G.; Staalduinen, M.V.

    2015-01-01

    Anonymity networks like Tor harbor many underground markets and discussion forums dedicated to the trade of illegal goods and services. As they are gaining in popularity, the analysis of their content and users is becoming increasingly urgent for many different parties, ranging from law enforcement

  13. Low-level waste forum meeting reports

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    This paper provides highlights from the 1995 summer meeting of the Low Level radioactive Waste Forum. Topics included: new developments in state and compacts; federal waste management; DOE plans for Greater-Than-Class C waste management; mixed wastes; commercial mixed waste management; international export of rad wastes for disposal; scintillation cocktails; license termination; pending legislation; federal radiation protection standards.

  14. Asian & Pacific Islander American Health Forum

    Science.gov (United States)

    ... Report.pdf [1.2MB] Obesity and Overweight Among Asian American Children and Adolescents 2016.04.28-OBESITY AND ... Month Stay Connected! Receive the latest APIAHF updates Asian & Pacific Islander American Health Forum. All rights reserved. One Kaiser Plaza, ...

  15. Low-level waste forum meeting reports

    International Nuclear Information System (INIS)

    1995-01-01

    This paper provides highlights from the 1995 summer meeting of the Low Level radioactive Waste Forum. Topics included: new developments in state and compacts; federal waste management; DOE plans for Greater-Than-Class C waste management; mixed wastes; commercial mixed waste management; international export of rad wastes for disposal; scintillation cocktails; license termination; pending legislation; federal radiation protection standards

  16. Facilitating Learning Spaces in Forum Theatre

    Science.gov (United States)

    Rae, Jan

    2013-01-01

    Purpose: The purpose of this paper is to evaluate the extent to which forum theatre interventions can support non-hierarchical approaches to learning, development and change management initiatives in organisations. Design/methodology/approach: Semi-structured interviews were carried out with theatre consultancies, actors/facilitators,…

  17. Self construction in schizophrenia: a discourse analysis.

    Science.gov (United States)

    Meehan, Trudy; MacLachlan, Malcolm

    2008-06-01

    Lysaker and Lysaker (Theory and Psychology, 12(2), 207-220, 2002) employ a dialogical theory of self in their writings on self disruption in schizophrenia. It is argued here that this theory could be enriched by incorporating a discursive and social constructionist model of self. Harr's model enables researchers to use subject positions to identify self construction in people with a diagnosis of schizophrenia that the dialogical model, using analysis of narrative, does not as easily recognize. The paper presents a discourse analysis of self construction in eight participants with a diagnosis of schizophrenia. Transcripts from semi-structured interviews are analysed, wherein focus falls on how participants construct self in talk through the use of subject positioning. The findings indicate that Harr's theory of self and the implied method of discourse analysis enables more subtle and nuanced constructions of self to be identified than those highlighted by Lysaker and Lysaker (Theory and Psychology, 12(2), 207-220, 2002). The analysis of subject positions revealed that participants constructed self in the form of Harr's (The singular self: An introduction to the psychology of personhood, 1998, London: Sage) self1, self2, and self3. The findings suggest that there may be constructions of self used by people diagnosed with schizophrenia that are not recognized by the current research methods focusing on narrative. The paper argues for the recognition of these constructions and by implication a model of self that takes into account different levels of visibility of self construction in talk.

  18. 78 FR 19024 - Lithium Ion Batteries in Transportation Public Forum

    Science.gov (United States)

    2013-03-28

    ... NATIONAL TRANSPORTATION SAFETY BOARD Lithium Ion Batteries in Transportation Public Forum On Thursday and Friday, April 11-12, 2013, the National Transportation Safety Board (NTSB) will convene a forum titled, ``Lithium Ion Batteries in Transportation.'' The forum will begin at 9:00 a.m. on both...

  19. Finding Question-Answer Pairs from Online Forums

    DEFF Research Database (Denmark)

    Cong, Gao; Wang, Long; Lin, Chin-Yew

    2008-01-01

    Online forums contain a huge amount of valuable user generated content. In this paper we address the problem of extracting question-answer pairs from forums. Question-answer pairs extracted from forums can be used to help Question Answering services (e.g. Yahoo! Answers) among other applications...

  20. 76 FR 71081 - Public Aircraft Oversight Safety Forum

    Science.gov (United States)

    2011-11-16

    ... NATIONAL TRANSPORTATION SAFETY BOARD Public Aircraft Oversight Safety Forum The National Transportation Safety Board (NTSB) will convene a Public Aircraft Oversight Safety Forum which will begin at 9 a... ``Public Aircraft Oversight Forum: Ensuring Safety for Critical Missions'', are to (1) raise awareness of...

  1. Suicidal behavior in the older patient with schizophrenia

    Science.gov (United States)

    Kasckow, John; Montross, Lori; Prunty, Laurie; Fox, Lauren; Zisook, Sidney

    2011-01-01

    Little is known about treating elderly suicidal patients with schizophrenia. The purpose of this article is to review the literature dealing with this population and to discuss what is required to advance this field. Most available studies from middle-aged and older individuals suggest that risk factors include hopelessness, lower quality of life, past traumatic events, depressive symptoms, lifetime suicidal ideation and past attempts; it is not clear whether these findings are generalizable to geriatric populations. Although little treatment research has been performed in older suicidal patients with schizophrenia, an integrated psychosocial and pharmacologic approach is recommended. In addition, one recent study augmented antipsychotic treatment with an SSRI (i.e., citalopram) in a sample of middle-aged and older individuals with schizophrenia with subsyndromal depression; in that study, serotonin selective reuptake inhibitor augmentation reduced depressive symptoms and suicidal ideation. More research is required to better understand suicidal behavior in older patients with schizophrenia. PMID:22028735

  2. Sistem Pakar Untuk mendiagnosis Gangguan Jiwa Schizophrenia

    Directory of Open Access Journals (Sweden)

    Landung Sudarmana

    2018-01-01

    Full Text Available Patients with mental illness (schizophrenia are quite large. According to the results of Basic Health Research in 2015, there is 0.467 percent of the population in Indonesia, in other hands, 1.093.150 Indonesians were suffered from schizophrenia, if schizophrenia does not get attention and appropriate treatment, it will be very bad for the patient. Community stigma about mental disorder often leads schizophrenia patients to be too late taken to a health facility. People believed that schizophrenia is caused by mystical things so that the first treatment is brought the patients to alternative medications. The development of a very rapid computer nowadays makes us easily build a web-based expert system. This expert system is trying to find a satisfactory solution as an expert does. The system was developed to diagnose the schizophrenic mental disorder and the diagnosis was done by analyzing the inputs symptoms, in the form of checklists of what people were felt, then choosing the density of its severity. The results of the diagnosis provide an outcome, i.e. the names of the disease along with the possible percentage value generated based on the selected symptoms. This research intended to build an expert system using PHP and MySQL programming language to store its database, while the inference method using forward chaining is the process of tracing that begins by displaying a data set or convincing facts to the final conclusion. This research resulted a diagnosis schizophrenic mental disorder expert system that is capable to early diagnosing schizophrenic disorder, based on the symptoms that have been selected by the user with a simple appearance that is easy to understand and can be accessed by many users.

  3. Mysticism and schizophrenia

    DEFF Research Database (Denmark)

    Parnas, Josef; Henriksen, Mads Gram

    2016-01-01

    Mysticism and schizophrenia are different categories of human existence and experience. Nonetheless, they exhibit important phenomenological affinities, which, however, remain largely unaddressed. In this study, we explore structural analogies between key features of mysticism and major clinical......-phenomenological aspects of the schizophrenia spectrum disorders-i.e. attitudes, the nature of experience, and the 'other', mystical or psychotic reality. Not only do these features gravitate around the issue of the basic dimensions of consciousness, they crucially seem to implicate and presuppose a specific alteration...

  4. Furthering patient adherence: a position paper of the international expert forum on patient adherence based on an internet forum discussion.

    Science.gov (United States)

    van Dulmen, Sandra; Sluijs, Emmy; van Dijk, Liset; de Ridder, Denise; Heerdink, Rob; Bensing, Jozien

    2008-02-27

    As the problem of patient non-adherence persists and a solution appears hard to be found, it continues to be important to look for new ways to further the issue. We recently conducted a meta-review of adherence intervention studies which yielded a preliminary agenda for future research, practice and theory development in patient adherence. The objective of the present project was to find out to what extent adherence experts consider this agenda relevant and feasible. The thirty-five corresponding authors of the review studies included in the meta-review were invited to join the International Expert Forum on Patient Adherence and to participate in a four-week web-based focus group discussion. The discussion was triggered by the points on the preliminary agenda presented as propositions to which forum members could react. Two researchers analysed the transcripts and selected relevant phrases. Twenty adherence experts participated. Various ideas and viewpoints were raised. After the closure of the web-site, the expert forum was asked to authorize the synthesis of the discussion, to list the propositions in order of priority and to answer a few questions on the use of the web-based focus group as a tool to obtain expert opinions. Their ranking showed that the development of simple interventions is the most promising step to take in fostering patient adherence, preferably within a multidisciplinary setting of medical, pharmaceutical, social and technical science and, not in the least, by incorporating patients' perspectives. For enhancing adherence, the development of simple interventions originating from a multidisciplinary perspective including patients' input, appears most promising. Disclosing patients' perspectives requires open communication about patients' expectations, needs and experiences in taking medication and about what might help them to become and remain adherent.

  5. Furthering patient adherence: A position paper of the international expert forum on patient adherence based on an internet forum discussion

    Directory of Open Access Journals (Sweden)

    Heerdink Rob

    2008-02-01

    Full Text Available Abstract Background As the problem of patient non-adherence persists and a solution appears hard to be found, it continues to be important to look for new ways to further the issue. We recently conducted a meta-review of adherence intervention studies which yielded a preliminary agenda for future research, practice and theory development in patient adherence. The objective of the present project was to find out to what extent adherence experts consider this agenda relevant and feasible. Methods The thirty-five corresponding authors of the review studies included in the meta-review were invited to join the International Expert Forum on Patient Adherence and to participate in a four-week web-based focus group discussion. The discussion was triggered by the points on the preliminary agenda presented as propositions to which forum members could react. Two researchers analysed the transcripts and selected relevant phrases. Results Twenty adherence experts participated. Various ideas and viewpoints were raised. After the closure of the web-site, the expert forum was asked to authorize the synthesis of the discussion, to list the propositions in order of priority and to answer a few questions on the use of the web-based focus group as a tool to obtain expert opinions. Their ranking showed that the development of simple interventions is the most promising step to take in fostering patient adherence, preferably within a multidisciplinary setting of medical, pharmaceutical, social and technical science and, not in the least, by incorporating patients' perspectives. Conclusion For enhancing adherence, the development of simple interventions originating from a multidisciplinary perspective including patients' input, appears most promising. Disclosing patients' perspectives requires open communication about patients' expectations, needs and experiences in taking medication and about what might help them to become and remain adherent.

  6. Unlocking the treasure trove: from genes to schizophrenia biology.

    Science.gov (United States)

    McCarthy, Shane E; McCombie, W Richard; Corvin, Aiden

    2014-05-01

    Significant progress is being made in defining the genetic etiology of schizophrenia. As the list of implicated genes grows, parallel developments in gene editing technology provide new methods to investigate gene function in model systems. The confluence of these two research fields--gene discovery and functional biology--may offer novel insights into schizophrenia etiology. We review recent advances in these fields, consider the likely obstacles to progress, and consider strategies as to how these can be overcome.

  7. Association analysis of 94 candidate genes and schizophrenia-related endophenotypes.

    Directory of Open Access Journals (Sweden)

    Tiffany A Greenwood

    Full Text Available While it is clear that schizophrenia is highly heritable, the genetic basis of this heritability is complex. Human genetic, brain imaging, and model organism studies have met with only modest gains. A complementary research tactic is to evaluate the genetic substrates of quantitative endophenotypes with demonstrated deficits in schizophrenia patients. We used an Illumina custom 1,536-SNP array to interrogate 94 functionally relevant candidate genes for schizophrenia and evaluate association with both the qualitative diagnosis of schizophrenia and quantitative endophenotypes for schizophrenia. Subjects included 219 schizophrenia patients and normal comparison subjects of European ancestry and 76 schizophrenia patients and normal comparison subjects of African ancestry, all ascertained by the UCSD Schizophrenia Research Program. Six neurophysiological and neurocognitive endophenotype test paradigms were assessed: prepulse inhibition (PPI, P50 suppression, the antisaccade oculomotor task, the Letter-Number Span Test, the California Verbal Learning Test-II, and the Wisconsin Card Sorting Test-64 Card Version. These endophenotype test paradigms yielded six primary endophenotypes with prior evidence of heritability and demonstrated schizophrenia-related impairments, as well as eight secondary measures investigated as candidate endophenotypes. Schizophrenia patients showed significant deficits on ten of the endophenotypic measures, replicating prior studies and facilitating genetic analyses of these phenotypes. A total of 38 genes were found to be associated with at least one endophenotypic measure or schizophrenia with an empirical p-value<0.01. Many of these genes have been shown to interact on a molecular level, and eleven genes displayed evidence for pleiotropy, revealing associations with three or more endophenotypic measures. Among these genes were ERBB4 and NRG1, providing further support for a role of these genes in schizophrenia susceptibility

  8. On New Means or New Forms of Investigation. A Methodological Proposal for Online Social Investigation through a Virtual Forum

    Directory of Open Access Journals (Sweden)

    Rubén Arriazu Muñoz

    2007-09-01

    Full Text Available Processes and instruments of communication have constituted an important object for Internet researchers, and have been investigated using qualitative methodologies in social research. The most common strategy has been to adapt orthodox instruments and procedures to the virtual context. In this paper I address the following questions in order to develop a framework for virtual research. Using a virtual forum as starting point, I ask: Is virtual research a new taxonomy or an extension of conventional social research techniques? Is virtual research located at the same level as face-to-face research? Is it a new communicational research form? This paper presents a methodological approach using virtual forums as tools where asynchronous communication flows. I analyze the use of virtual forums in interaction with the social context, and articulate the method that emerges from this fieldwork situation. URN: urn:nbn:de:0114-fqs0703374

  9. Right To Health And Judicialization: A Study About Its Efficiency Of The National Judiciary Forum On Health

    OpenAIRE

    Edith Maria Barbosa Ramos; Isadora Moraes Diniz

    2017-01-01

    In the past few years, the judicialization of health has become a problematic theme to the Judiciary. In this contexto, the National Justice Council to puts itself in the role of promoting a judicial public policy for defense and guarantee of health rights, by the National Judiciary Forum on Health institution. This study aims to evaluate the efficacy of the National Forum practice in offering solutions and alternatives to the health judicialization process. The research was carried out durin...

  10. Transcranial magnetic stimulation in schizophrenia.

    Science.gov (United States)

    Zaman, Rashid; Thind, Dilraj; Kocmur, Marga

    2008-11-01

    Transcranial magnetic stimulation (TMS) is a non-invasive and painless way of stimulating the neural tissue (cerebral cortex, spinal roots, and cranial and peripheral nerves). The first attempts at stimulating the neural tissue date back to 1896 by d'Arsonval; however, it was successfully carried out by Barker and colleagues in Sheffield, UK, in 1985. It soon became a useful tool in neuroscience for neurophysiologists and neurologists and psychiatrists. The original single-pulse TMS, largely used as an investigative tool, was further refined and developed in the early 1990s into what is known as repetitive TMS (rTMS), having a frequency range of 1-60 Hz. The stimulation by both TMS and rTMS of various cortical regions displayed alteration of movement, mood, and behavior, leading researchers to investigate a number of psychiatric and neuropsychiatric disorders, as well as to explore its therapeutic potential. There is now a large amount of literature on the use of TMS/rTMS in depression; however, its use in schizophrenia, both as an investigative and certainly as a therapeutic tool is relatively recent with a limited but increasing number of publications. In this article, we will outline the principles of TMS/rTMS and critically review their use in schizophrenia both as investigative and potential therapeutic tools.

  11. Grief and mourning in schizophrenia.

    Science.gov (United States)

    Wittmann, Daniela; Keshavan, Matcheri

    2007-01-01

    Depression and suicidality after first episode of psychosis are well-documented responses in patients with schizophrenia (Addington, Williams, Young, & Addington, 2004). The understanding of depression and suicidality has been increasingly refined through careful study. Researchers have identified a number of factors that may cause depression such as insight into the illness, feelings of loss and inferiority about the illness as a damaging life event, hopelessness about having a viable future with the illness and mourning for losses engendered by the illness. The authors argue that grief and mourning are not just an occasional reaction to the diagnosis of schizophrenia, but are a necessary part of coming to terms with having the illness. They offer three case examples, each of which illuminates a distinct way in which psychosis and mourning may be related--psychosis as a loss of former identity, psychosis as offering meaning and transformation, and psychosis as a way of coping with the inability to mourn. In their view, recovery depends on mourning illness-related losses, developing personal meaning for the illness, and moving forward with "usable insight" and new identity (Lewis, 2004) that reflects a new understanding of one's strengths and limitations with the illness.

  12. AKIBAT PEMILIHAN FORUM DALAM KONTRAK YANG MEMUAT KLAUSA ARBITRASE

    Directory of Open Access Journals (Sweden)

    Bambang Sutiyoso

    2012-07-01

    Full Text Available Our research attempts to understand the absolute competence of arbitration and its development in practice as well as the effect of the parties' choice of jurisdiction in a contract containing arbitration clause. This research is expected to be able to explain the competence dispute between arbitration and court to justiciables. We find that choice in jurisdiction would negate the rights of the parties to submit their dispute to district court. In practice, deviation where courts may ignore the arbitration clause, the parties' good faith and consistency of the court play a significant role to further develop the arbitration process. Penelitian yuridis-normatif ini dilakukan untuk mengetahui kompetensi absolut arbitrase dan perkembangannya dalam praktik, serta akibat hukum pilihan forum dalam kontrak berklausula arbitrase bagi para pihak yang berpekara. Penelitian ini diharapkan dapat menerangkan para pencari keadilan perihal sengketa kewenangan mengadili antara arbitrase dan pengadilan. Hasil penelitian menunjukkan bahwa pilihan forum akan meniadakan hak para pihak dan sikap pengadilan yang konsisten memiliki peranan besar untuk mengembangkan arbitrase.

  13. [The cognitive paradigm in the rehabilitation of schizophrenia - focusing on cognitive remediation].

    Science.gov (United States)

    Muth, Veronika; Gyüre, Támas; Váradi, Enikö

    2015-09-01

    Neurocognitive deficits are core features of schizophrenia and well known to the specialists, concerning researches in Hungary as well. Significance of the topic derives from the fact that according to our present knowledge this is the prime symptom principally affecting everyday functioning and limits benefit of rehabilitation opportunities. The classic psychiatric rehabilitation toolset, either pharmacological or psychosocial, does not provide effective and specific assistance to alleviate the symptoms of the neurocognitive deficits. Despite the increasing presence of the neurocognitive-oriented rehabilitation in international publications and professional forums, cognitive development is rather neglected topic in the Hungarian literature; while the therapeutic practice - with the exception of one institution - is absent from the repertoire of the Hungarian rehabilitation. The purpose of this study is the multi-faceted presentation of recent results in the field of the cognitive remediation, describing the position of cognitive training and its place in the rehabilitation of schizophrenia, with the aim to gain reputation and promote clinical practice among the Hungarian experts. Cognitive remediation is a behavioral training, based on learning theory, with the aim of extensive and long-lasting improvement of cognitive functions of patients suffering from schizophrenia or other mental disorders. Despite the deceptively similar acronym it is important to distinguish this method from the cognitive behavioral therapy which shows similarity in its learning theory basis, but remediation involves much more educational features. Cognitive remediation is not a unified technique, different settings are known, but regardless of form factors it clearly has a specific and positive effect on the neurocognitive functions. It fits well into the rehabilitation methodology, in fact this embeddedness significantly increases its effectiveness and supports emergence of skills in

  14. Toward a Holistic Approach to Spiritual Health Care for People With Schizophrenia.

    Science.gov (United States)

    Ho, Rainbow T H; Wan, Adrian H Y; Chan, Caitlin K P

    2016-01-01

    Medical and behavioral treatments are the predominant types of rehabilitation services for people with schizophrenia. Spirituality in people with schizophrenia remains poorly conceptualized, thereby limiting knowledge advancement in the area of spiritual health care services. To provide a framework for better clinical and research practices, we advocate a holistic approach to investigating spirituality and its application in spiritual health care services of people with schizophrenia.

  15. Identity Disturbance, Feelings of Emptiness, and the Boundaries of the Schizophrenia Spectrum

    DEFF Research Database (Denmark)

    Zandersen, Maja; Parnas, Josef

    2018-01-01

    in schizophrenia and schizotypal personality disorder. Unfortunately, the diagnostic manuals offer limited insight into the nature of these criteria, including possible deviations and similarities with schizophrenia spectrum symptomatology. In this article, we attempt to clarify the concepts of identity......Historical and current research on borderline personality disorder reveal certain affinities with schizophrenia spectrum psychopathology. This is also the case for the borderline criteria of "identity disturbance" and "feelings of emptiness," which reflect symptomatology frequently found...

  16. The development of the Asian Forum for Polar Sciences (AFoPS)

    Science.gov (United States)

    Kim, Yeadong; Jeong, Jihoon

    2015-12-01

    The Asian Forum for Polar Sciences (AFoPS), an international forum of Asian polar research institutes, was established for the advancement of polar sciences among its members in 2004. The Forum has served as an important medium of Asian collective endeavors for polar affairs in human and information exchange, research collaboration, and logistics cooperation for the last decade. The historical development of the AFoPS in retrospect can be divided into four phases: inception and establishment (2003-2004), growth and expansion (2005-2007), review and restructuring (2008-2011), and achievements and further measures (2012-2014). The progress of the AFoPS has not been linear and this trend will continue into the next decades. The Forum, however, clearly made achievements in this period of time, realizing multilateral research and logistics cooperation that would have been previously unimaginable; by doing so, it has laid the foundation for the future. Responsible for a great portion of the world's polar activities, the AFoPS will rise to meet the expectations of the world by producing notable research output, initiating international cooperative programs, and supporting non-polar Asian countries with education and research collaboration. These are the tasks of the AFoPS for the next decade and they require strategy that promotes and facilitates collaboration in a practical way and draws attention of non-polar Asian countries to the polar sciences.

  17. Schizophrenia, Sleep and Acupuncture

    NARCIS (Netherlands)

    Bosch, M.P.C.; Noort, M.W.M.L. van den

    2008-01-01

    This book is an introduction for professionals in Western medicine and for acupuncturists on the use of acupuncture in treatment of schizophrenia and sleep disorders. Acupuncture has long been used in Traditional Chinese Medicine (TCM) in mental health and sleep disorders. This book aims to build a

  18. Depression in Kraepelinian schizophrenia

    African Journals Online (AJOL)

    related problems and poorer social and family relationships, show a lower level of ... Furthermore, suicide terminates the lives of an estimated 10 - 15% ... deterioration of functioning in social, work and self-care domains. .... quality of life in outpatients with schizophrenia spectrum disorders? ... Acta Psychiatr Scand 2002;.

  19. Glutamatergic System and Schizophrenia

    Directory of Open Access Journals (Sweden)

    Osman Ozdemir

    2016-12-01

    Full Text Available Glutamate is the major excitatory neurotransmitter in the brain. It has a role several cognitive functions including learning, memory and perception. Glutamatergic neurotransmission is also involved in regulating neuronal migration, synaptogenesis, and the pruning neurons. Glutamatergic exci-totoxicity has been implicated in various neuropsychiatric disorders. Accumulating evidence suggests that glutamatergic dysfunction may contribute to the pathogenesis of schizophrenia. The N-methyl-D-aspartic acid (NMDA receptor antagonists such as phencyclidine and ketamine can cause both the positive and negative symptoms psychotic symptoms in normal humans, and worsen these symptoms in persons with schizophrenia. Hence, it has been hypotesized that schizophrenia may be associated with decreased NMDA-receptor activity. According to the hypothesis, NMDA reseptor hypofunction can lead to decreased inhibition of glutamatergic neurons and excessive glutamate release. Finally, the reduction of gray matter in several brain regions seen in patients with schizophrenia has been suggested to be the result of neurotoxicity mediated by NMDA receptors. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2016; 8(4.000: 394-405

  20. Social cognition in schizophrenia

    NARCIS (Netherlands)

    Maat, A.

    2014-01-01

    Schizophrenia is a chronic psychiatric disorder, incorporating a wide range of symptoms that may occur at certain stages of the disease. The core symptoms can largely be divided into positive symptoms, e.g. hallucinations and delusions, and negative symptoms, e.g. apathia and emotional flattening.

  1. Iconic decay in schizophrenia.

    Science.gov (United States)

    Hahn, Britta; Kappenman, Emily S; Robinson, Benjamin M; Fuller, Rebecca L; Luck, Steven J; Gold, James M

    2011-09-01

    Working memory impairment is considered a core deficit in schizophrenia, but the precise nature of this deficit has not been determined. Multiple lines of evidence implicate deficits at the encoding stage. During encoding, information is held in a precategorical sensory store termed iconic memory, a literal image of the stimulus with high capacity but rapid decay. Pathologically increased iconic decay could reduce the number of items that can be transferred into working memory before the information is lost and could thus contribute to the working memory deficit seen in the illness. The current study used a partial report procedure to test the hypothesis that patients with schizophrenia (n = 37) display faster iconic memory decay than matched healthy control participants (n = 28). Six letters, arranged in a circle, were presented for 50 ms. Following a variable delay of 0-1000 ms, a central arrow cue indicated the item to be reported. In both patients and control subjects, recall accuracy decreased with increasing cue delay, reflecting decay of the iconic representation of the stimulus array. Patients displayed impaired memory performance across all cue delays, consistent with an impairment in working memory, but the rate of iconic memory decay did not differ between patients and controls. This provides clear evidence against faster loss of iconic memory representations in schizophrenia, ruling out iconic decay as an underlying source of the working memory impairment in this population. Thus, iconic decay rate can be added to a growing list of unimpaired cognitive building blocks in schizophrenia.

  2. Formal thought disorder in schizophrenia and bipolar disorder: A systematic review and meta-analysis.

    Science.gov (United States)

    Yalincetin, Berna; Bora, Emre; Binbay, Tolga; Ulas, Halis; Akdede, Berna Binnur; Alptekin, Koksal

    2017-07-01

    Historically, formal thought disorder has been considered as one of the distinctive symptoms of schizophrenia. However, research in last few decades suggested that there is a considerable clinical and neurobiological overlap between schizophrenia and bipolar disorder (BP). We conducted a meta-analysis of studies comparing positive (PTD) and negative formal thought disorder (NTD) in schizophrenia and BP. We included 19 studies comparing 715 schizophrenia and 474 BP patients. In the acute inpatient samples, there was no significant difference in the severity of PTD (d=-0.07, CI=-0.22-0.09) between schizophrenia and BP. In stable patients, schizophrenia was associated with increased PTD compared to BP (d=1.02, CI=0.35-1.70). NTD was significantly more severe (d=0.80, CI=0.52-0.1.08) in schizophrenia compared to BP. Our findings suggest that PTD is a shared feature of both schizophrenia and BP but persistent PTD or NTD can distinguish subgroups of schizophrenia from BP and schizophrenia patients with better clinical outcomes. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. Portrayals of schizophrenia by entertainment media: a content analysis of contemporary movies.

    Science.gov (United States)

    Owen, Patricia R

    2012-07-01

    Critics of entertainment media have indicated that cinematic depictions of schizophrenia are stereotypic and characterized by misinformation about symptoms, causes, and treatment. The pervasiveness and nature of misinformation are difficult to ascertain because of the lack of empirically based studies of movies portraying schizophrenia. This study analyzed portrayals of schizophrenia in contemporary movies to ascertain prevalence of stereotypes and misinformation about schizophrenia. English-language movies featuring at least one main character with schizophrenia that were released for showing in theaters between 1990 and 2010 were analyzed for depictions of schizophrenia. Two researchers independently rated each character with a checklist that assessed demographic characteristics, symptoms and stereotypes, causation, and treatment. Forty-two characters from 41 movies were identified, a majority of whom were male and Caucasian. Most characters displayed positive symptoms of schizophrenia. Delusions were featured most frequently, followed by auditory and visual hallucinations. A majority of characters displayed violent behavior toward themselves or others, and nearly one-third of violent characters engaged in homicidal behavior. About one-fourth of characters committed suicide. Causation of schizophrenia was infrequently noted, although about one-fourth of movies implied that a traumatic life event was significant in causation. Of movies alluding to or showing treatment, psychotropic medications were most commonly portrayed. The finding that misinformation and negative portrayals of schizophrenia in contemporary movies are common underscores the importance of determining how viewers interpret media messages and how these interpretations inform attitudes and beliefs both of the general public and of people with schizophrenia.

  4. Knowledge details in web forums: how high or low above the ground?

    OpenAIRE

    Mikami, Yoshiki; Abd Rozan, Mohd Zaidi

    2006-01-01

    While entertainment web forums provide a dynamic medium for interaction, not many researchers feel the need to go deeply into the contents. One of the reasons behind this attitude lies on a widely perceived assumption that web forums do not deal with knowledge matter and have the inclination to take place only as small talk. In this paper, we will mainly inspect the components of knowledge as are being handled by the six service-men of Kipling’s 5W1H framework. Based on our observation on ...

  5. Toward Bridging a Gap Between Experts and Local Community Through Repetitive Dialogue Forum

    International Nuclear Information System (INIS)

    Yagi, Ekou; Takahashi, Makoto; Kitamura, Masaharu

    2003-01-01

    Establishment of mutual trust between experts and public is an issue of critical importance for better nuclear policy design in Japan. A research project named Facilitation of Risk-based Decision-Making on Technical Systems (FRIDMATS) bas been launched in 2002 to meet the need. In the first phase of the project, efforts have been focused on developing a risk perception model of public to be employed as a reference for improved risk communication. A series of dialogue forums have been held in municipalities where nuclear facilities are sited to obtain guidelines for the model development. Current status of the forum and summary of the acquired information are described in this paper

  6. Democracy to Come: Active Forums as Indicator Suites for e-Participation and e-Governance

    Science.gov (United States)

    Rodan, Debbie; Balnaves, Mark

    There is in modern industrial societies a ‘civic deficit’ Civic engagement in the traditional sense of community values and civic participation is declining (Putman 2000). What has not been examined is the ways in which various media including new media may provide real options for participatory cultures and participatory democracy now and in the future. Undoubtedly there are differences between participatory cultures that are considered a ‘genuine’ contribution to representational democracy and those that are not. This paper, based on initial research into Internet activism, will examine GetUp! as a specific example of an active forum that the authors argue enable participatory citizenship through media participation. While there are very few examples of active forums that might be considered a ‘genuine’ contribution to representational democracy there are clear signals that activism through active forums is maturing into a potent democratic force.

  7. LLW (Low-Level Waste) Forum meeting report, February 10-13, 1998, San Diego, CA

    International Nuclear Information System (INIS)

    1998-01-01

    The Low-Level Radioactive Waste Forum met in San Diego, California, on February 10--13, 1998. Twenty-four Forum Participants, Alternate Forum Participants, and meeting designees representing 19 compacts, host states, and unaffiliated states participated. Additional information was provided by 19 resource people from, variously, the States of California, Colorado, and Utah; the National Governors' Association; the Department of the Army; EPA; DOE and DOE's National Low-Level Waste Management Program; NRC; the Electric Power Research Institute and the Nuclear Energy Institute; US Ecology, Chem-Nuclear Systems, Envirocare of Utah, and Waste Control Specialists (represented by Egan and Associates); and Rocketdyne Propulsion and Power. Also in attendance, as observers, were six other state and compact officials; a staff person from DOE's National Low-Level Waste Management Program; one NRC headquarters staff person; and seven representatives of other interested parties, including a regional generators' organization, two generators, one California anti-nuclear group, and two private companies

  8. Early and sustained dynamic intervention in schizophrenia

    DEFF Research Database (Denmark)

    Rosenbaum, Bent; Rosenbaum, Bent

    2009-01-01

    This paper is based on the Danish National Schizophrenia Project manual for psychodynamic individual psychotherapy with persons in states of schizophrenia. The methods for engaging with and treating a patient with schizophrenia in a supportive, psychodynamic way are described....

  9. Prevalence of obsessive compulsive symptoms among patients with schizophrenia

    Directory of Open Access Journals (Sweden)

    Smita Hemrom

    2009-01-01

    Full Text Available Background: Obsessive compulsive symptoms in schizophrenia are well recognized but are a less-researched entity. These symptoms have important implications for management and prognosis. Aim: To find out the prevalence of obsessive compulsive symptoms among patients with schizophrenia. Materials and Methods: A total of 90 hospitalized patients with schizophrenia diagnosed according to DCR of ICD-10 criteria were selected for the study. Padua inventory and Yale-Brown Obsessive Compulsive Scale were applied to find out the prevalence and nature of obsessive compulsive symptoms . Results: It was found that 10% of schizophrenic patients had obsessive compulsive symptoms. Conclusion: Obsessive compulsive symptoms are prevalent in patients with schizophrenia. The presence of comorbidity should be explored for adequate management.

  10. Westinghouse Savannah River Site vendor forum: An innovative cooperative technology development success

    International Nuclear Information System (INIS)

    Sturm, H.F. Jr.

    1996-01-01

    The Westinghouse Savannah River Company (WSRC) Supplier Environmental and Waste Management Information Exchange Forum was held August 31 - September 1, 1993. The forum, which was planned and conducted in concert with the Department of Energy Savannah River Operations Office (DOE-SROO), was held to foster a technical exchange in which new, innovative technologies were proposed by suppliers, to identify more cost-effective methods to apply to future and on-going activities, to increase use of the private sector, and to promote partnerships with other industries. The two day forum provided the opportunity for WSRC and DOE-SR to review program activities and challenges in five major areas, Savannah River Technology Center, Solid Waste Facilities, Environmental Restoration, Environmental Monitoring, and Decontamination and Decommissioning through formal presentations. The second day was designed to provide suppliers the opportunity to talk about current and future activities and challenges with representatives of each of these areas at display booths, special high interest topic interactive sessions, and site tours. Each attendee was then invited to submit pre-proposals relative to the abstracts presented in The Special Consolidate Solicitation for Environmental and Waste Management Basic and Applied Research and Research-Related Development and/or Demonstration No. E10600-E1 document. Twenty-five contracts totaling $12 million were awarded. Twenty-four contracts have now been completed. This paper provides an overview of the pre forum activities, the forum, post-forum and proposal review process, and most importantly a description of the technologies demonstrated, the benefits and savings derived, and future use potential from a DOE perspective, as well as technology transfer and industrial partnership potential

  11. La question de l’efficacité des forums virtuels sur la réussite How effective are virtual forums on succes?

    Directory of Open Access Journals (Sweden)

    Sandoss Ben Abid Zarrouk

    2011-12-01

    Full Text Available L’objet de cet article est de tenter de donner une estimation de l’efficacité, en termes de réussite, des forums d’échanges virtuels. C’est à partir de l’étude d’une plateforme de formation d’enseignement en ligne qui permet la préparation au Diplôme d’Accès aux Études Universitaires (DAEU de l’université de Haute Alsace, que nous apportons des éléments de réponses. Les résultats montrent que les étudiants qui utilisent les forums d’échanges afin d’envoyer des messages ont des taux de réussite plus élevés comparativement à ceux qui n’envoient pas de messages.The aim of this paper is to provide an estimation of the effectiveness of Web forums used for online learning. The study of the online learning platform that enables adult students to prepare the DAEU (diploma granting access to university or equivalent at the university of Haute Alsace, provides us with information about this. The results of this research show that students who use discussion forums to post messages have higher success rates than those who do not.

  12. Investigating Relationship between Discourse Behavioral Patterns and Academic Achievements of Students in SPOC Discussion Forum

    Science.gov (United States)

    Liu, Zhi; Zhang, Wenjing; Cheng, Hercy N. H.; Sun, Jianwen; Liu, Sannyuya

    2018-01-01

    As an overt expression of internal mental processes, discourses have become one main data source for the research of interactive learning. To deeply explore behavioral regularities among interactions, this article firstly adopts the content analysis method to summarize students' engagement patterns within a course forum in a small private online…

  13. Forum: The Lecture and Student Learning. What Is the Place of Lecture in Student Learning Today?

    Science.gov (United States)

    Stearns, Susan

    2017-01-01

    The author of this brief forum article argues that it is time to encourage faculty members to rethink student learning: encourage the scholarship of teaching and expose faculty to key research articles about student learning. Then, building on this knowledge, the academy needs to offer assistance to faculty in designing student-centered…

  14. The European vocation of the Romanian Atomic Forum. Participation to the FORATOM working groups

    International Nuclear Information System (INIS)

    Chirica, Teodor

    2004-01-01

    ROMATOM, the Romanian Atomic Forum, participates in the activity of the following FORATOM working groups: Quality Management, Business Excellence, Accession Task Force, Radioactive Waste Management, Civil Liability and Law Aspects, Climatic Changes. Recently, Romania was invited to attend the working groups for Research and Development and Community Waste Management

  15. Forum: Interpersonal Communication in Instructional Settings. The Interplay between Interpersonal Communication and Instructional Communication

    Science.gov (United States)

    Punyanunt-Carter, Narissra Maria; Arias, V. Santiago

    2017-01-01

    In this brief forum article, the authors suggest that in order to truly understand communication education, both interpersonal and instructional variables must be analyzed. Instructors, researchers, and scholars need to find balance between content and relationship aspects while being aware of context boundaries to truly assist in maximizing…

  16. An Examination of Computer Engineering Students' Perceptions about Asynchronous Discussion Forums

    Science.gov (United States)

    Ozyurt, Ozcan; Ozyurt, Hacer

    2013-01-01

    This study was conducted in order to reveal the usage profiles and perceptions of Asynchronous Discussion Forums (ADFs) of 126 computer engineering students from the Computer Engineering Department in a university in Turkey. By using a mixed methods research design both quantitative and qualitative data were collected and analyzed. Research…

  17. Take part in the Poster Forum

    CERN Multimedia

    2008-01-01

    The CERN Control Week will run from 17 to 23 May 2008. For the first time, the IT-CO group will be organising a "poster forum" on the theme of process control, which will be held in the main hall of Building 500 in Meyrin, near Restaurant No. 1 (see Bulletin No. 16/2008). If you wish to take part, there is still time to send your posters to Mathias Dutour or Stefan Lueders.

  18. When Bitcoin encounters information in an online forum: Using text mining to analyse user opinions and predict value fluctuation.

    Directory of Open Access Journals (Sweden)

    Young Bin Kim

    Full Text Available Bitcoin is an online currency that is used worldwide to make online payments. It has consequently become an investment vehicle in itself and is traded in a way similar to other open currencies. The ability to predict the price fluctuation of Bitcoin would therefore facilitate future investment and payment decisions. In order to predict the price fluctuation of Bitcoin, we analyse the comments posted in the Bitcoin online forum. Unlike most research on Bitcoin-related online forums, which is limited to simple sentiment analysis and does not pay sufficient attention to note-worthy user comments, our approach involved extracting keywords from Bitcoin-related user comments posted on the online forum with the aim of analytically predicting the price and extent of transaction fluctuation of the currency. The effectiveness of the proposed method is validated based on Bitcoin online forum data ranging over a period of 2.8 years from December 2013 to September 2016.

  19. When Bitcoin encounters information in an online forum: Using text mining to analyse user opinions and predict value fluctuation.

    Science.gov (United States)

    Kim, Young Bin; Lee, Jurim; Park, Nuri; Choo, Jaegul; Kim, Jong-Hyun; Kim, Chang Hun

    2017-01-01

    Bitcoin is an online currency that is used worldwide to make online payments. It has consequently become an investment vehicle in itself and is traded in a way similar to other open currencies. The ability to predict the price fluctuation of Bitcoin would therefore facilitate future investment and payment decisions. In order to predict the price fluctuation of Bitcoin, we analyse the comments posted in the Bitcoin online forum. Unlike most research on Bitcoin-related online forums, which is limited to simple sentiment analysis and does not pay sufficient attention to note-worthy user comments, our approach involved extracting keywords from Bitcoin-related user comments posted on the online forum with the aim of analytically predicting the price and extent of transaction fluctuation of the currency. The effectiveness of the proposed method is validated based on Bitcoin online forum data ranging over a period of 2.8 years from December 2013 to September 2016.

  20. [Emotional valence of words in schizophrenia].

    Science.gov (United States)

    Jalenques, I; Enjolras, J; Izaute, M

    2013-06-01

    reflected the more neutral emotional valences collected. The results suggested that the emotional valences for the negative words were significantly greater in the patients than is observed in the collected norms (Ppositive words was significantly lower in the patients than in the collected norms (Pwords differed significantly in terms of evaluated emotional valence between patients and young adults. Despite their overall emotional impairments, the patients with schizophrenia had a very similar perception of word valence as controls. This result suggests that the emotional perception of most emotional words is preserved. This research provides data important to consider during rehabilitation. Moreover, this study will make it possible to select stimuli for use in future studies of emotion in patients. Copyright © 2012. Published by Elsevier Masson SAS.

  1. 2nd Developers@CERN Forum

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    Are you a Python guru or would you like to learn?   The Developers@CERN Forum is an event by developers, for developers, aimed at promoting knowledge and experience sharing. This edition will take place at the IT Amphitheatre, on the 30th and 31st of May afternoons. It will consist of a series of short presentations and workshops. The topic for this conference will be Python at CERN: language, frameworks and tools. Have you got an idea for a presentation or workshop? Then, tell us about it (deadline on 9th of May). Registration will open in early May. Please subscribe to developers-forum-announce@cern.ch mailing list for further information. This event will be made by developers for developers. We are counting on your presence, but also on your contributions! To learn more about the initiative, read the CERN Bulletin article. Organization You can get in touch us at developers-forum-organizers@cern.ch.

  2. Quality of Care and Outcomes of Heart Failure Among Patients With Schizophrenia in Denmark

    DEFF Research Database (Denmark)

    Jorgensen, Mette; Mainz, Jan; Egstrup, Kenneth

    2017-01-01

    care among patients with schizophrenia included patient-specific factors (age, gender, Global Assessment of Functioning [GAF] score, alcohol or drug abuse, duration of schizophrenia); provider-specific factors (quality of schizophrenia care); and system-specific factors (patient-volume defined......Research on the association between schizophrenia and the quality of care and clinical outcomes of heart failure (HF) remains sparse. This nationwide study compared the quality of care and clinical outcomes of HF among Danish patients with and without schizophrenia. In a population-based cohort...... study, we identified 36,718 patients with incident HF with hospital contacts, including 108 with schizophrenia, using Danish registries between 2004 and 2013. High quality of HF care was defined as receiving ≥ 80% guideline-recommended process-performance measures of care. Potential predictors of HF...

  3. Analysis of risk factors for schizophrenia with two different case definitions

    DEFF Research Database (Denmark)

    Sørensen, Holger J; Tidselbak Larsen, Janne; Mors, Ole

    2015-01-01

    Different case definitions of schizophrenia have been used in register based research. However, no previous study has externally validated two different case definitions of schizophrenia against a wide range of risk factors for schizophrenia. We investigated hazard ratios (HRs) for a wide range...... of risk factors for ICD-10 DCR schizophrenia using a nationwide Danish sample of 2,772,144 residents born in 1955-1997. We compared one contact only (OCO) (the case definition of schizophrenia used in Danish register based studies) with two or more contacts (TMC) (a case definition of at least 2 inpatient...... contacts with schizophrenia). During the follow-up, the OCO definition included 15,074 and the TMC 7562 cases; i.e. half as many. The TMC case definition appeared to select for a worse illness course. A wide range of risk factors were uniformly associated with both case definitions and only slightly higher...

  4. Forum | Accelerating respect @ CERN | 5 May | Council Chamber

    CERN Multimedia

    2015-01-01

    Forum for discussion: Accelerating respect @ CERN - What does this mean in our daily working lives?   Tuesday, 5 May at 2 p.m. Council Chamber Join our forum for discussion on the topic of “Respect in the workplace” where Alan Richter will be leading a discussion on the relationship between respect and trust, including some recent research on trust, and exploring the role of unconscious bias, how respect is differently interpreted across cultures, and the connection between respect, listening, and the appreciative inquiry process. Alan Richter is the president of QED Consulting, a 26-year-old company based in New York. He has consulted to organisations in the areas of leadership, values, culture and change and is a recognised pioneer in global diversity and international ethics. He has worked with CERN, NASA, the UN and many global companies and leading universities around the world. He has a Ph.D. in Philosophy from London University, and a Master’s degree fro...

  5. Generation 4 International Forum (GIF). 2015 Annual Report

    International Nuclear Information System (INIS)

    2016-01-01

    This ninth edition of the Generation IV International Forum (GIF) Annual Report highlights the main achievements of the Forum in 2015. On 26 February 2015, the Framework Agreement for International Collaboration on Research and Development of Generation IV Nuclear Energy Systems was extended for another ten years, thereby paving the way for continued collaboration among participating countries. GIF organised the 3. Symposium in Makuhari Messe, Japan in May 2015 to present progress made in the development of the six generation IV systems: the gas-cooled fast reactor, the sodium-cooled fast reactor, the supercritical-water-cooled reactor, the very-high-temperature reactor, the lead-cooled fast reactor and the molten salt reactor. The report gives a detailed description of progress made in the 11 existing project arrangements. It also describes the development of safety design criteria and guidelines for the sodium-cooled fast reactor, in addition to the outcome of GIF engagement with regulators on safety approaches for generation IV systems. (authors)

  6. Factors influencing physicians' knowledge sharing on web medical forums.

    Science.gov (United States)

    Lin, Tung Cheng; Lai, Ming Cheng; Yang, Shu Wen

    2016-09-01

    Web medical forums are relatively unique as knowledge-sharing platforms because physicians participate exclusively as knowledge contributors and not as knowledge recipients. Using the perspective of social exchange theory and considering both extrinsic and intrinsic motivations, this study aims to elicit the factors that significantly influence the willingness of physicians to share professional knowledge on web medical forums and develops a research model to explore the motivations that underlie physicians' knowledge-sharing attitudes. This model hypothesizes that constructs, including shared vision, reputation, altruism, and self-efficacy, positively influence these attitudes and, by extension, positively impact knowledge-sharing intention. A conventional sampling method and the direct recruitment of physicians at their outpatient clinic gathered valid data from a total of 164 physicians for analysis in the model. The empirical results support the validity of the proposed model and identified shared vision as the most significant factor of influence on knowledge-sharing attitudes, followed in descending order by knowledge-sharing self-efficacy, reputation, and altruism. © The Author(s) 2015.

  7. Application of a forum on the internet for risk communications

    International Nuclear Information System (INIS)

    Takizawa, Masayuki; Shobu, Nobuhiro

    2003-01-01

    A case of 'internet forum' that various kinds of person can exchange views on the theme of geological disposal on the internet is explained. It is managed by a third organization such as Mitsubishi Research Institute, Inc. To exchange views as fast as possible, on the basis of individual opinion, a private person or an acting partner can contribute to it without one's position. User ID and input password are need. Target is selected as the industries related to geological disposal in the nuclear power field, person interested in garbage problem, environmental problems, geological disposal and students in Japan. The construction of site has been modified on the basis of various viewpoints. The cumulative access number is increasing from 76 to 414 in the fiscal 1998 to 2000. The important factor on the internet forum is neutrality of site management, individual opinion, joining many participants. A questionnaire was carried out by 1000 person using internet. The results of questionnaire are reported. (S.Y.)

  8. EFFECTIVENESS OF THE FORUM METHOD FOR THE SELF DEVELOPMENT COURSE IN UKM AND ITS LINK WITH STUDENT INTEREST

    Directory of Open Access Journals (Sweden)

    Wan Zulkifli WAN HASSAN

    2015-07-01

    Full Text Available Student inability to explain concepts learnt in lessons using their own words academically and intellectually and their lack of interest in learning the subject are a cause of their incompetence in the development of their personality. This presents a challenge to lecturers that they should not rely entirely on conventional lectures and tutorials. Instead, there is a need to employ a variety of teaching methods to stimulate student minds and encourage them to pursue knowledge. As an effort to diversify learning and teaching methods, a study was conducted to improve weaknesses of teaching and learning methods by organizing to motivate students. This was done to help students realize that concepts learnt in the course are relevant to their daily life and to encourage them to seek knowledge of self development which can be applied outside the class. The fora were followed with an action research. This action research was aimed at analyzing the effectiveness of the forum as an alternative method of teaching and learning of the Self Development Course. A sample of 73 students of various academic faculties 2012/2013 were involved in the forum competition. The sample was divided into two groups: panelists group and audience group. Panelists wrote two reports on their experience from the beginning stage of preparing forum materials until the final stage of conducting the forum itself. Listeners groups were assessed as to their interest and observation to the forum content and its discussion while it was being conducted. The effectiveness of this strategy is based on analysis of student reports on the conducted forum and debates in it. Results show that forum received a positive response among the students. The forum approach increased student skills to relate to current issues in explaining facts they have learnt, encouraged cooperation among them to solve problems and increased interaction skill as well as built self-confidence. Therefore they could

  9. Predictors of resocialization of patients with schizophrenia: medico-sociological analysis

    Directory of Open Access Journals (Sweden)

    Zhukova О.A.

    2012-03-01

    Full Text Available Processes of urbanization, stressful events and other social trends of the modern world are considered as the social predictors determining the growth of frequency of mental illness. They are directly associated with manifestations of mental disorders, including schizophrenia. The majority of people is subjected to mental disorders living in unfavorable conditions. According to severe social consequences schizophrenia takes the leading position in psychiatry. Course of schizophrenia is one of the main clinical predictors of clinical and social prognosis. The research has established that the clinical predictors determining the severity of non-cancerous condition of patients with schizophrenia are not obligate in the socialization of the patients.

  10. The Role of Motivation in Cognitive Remediation for People with Schizophrenia.

    Science.gov (United States)

    Saperstein, Alice M; Medalia, Alice

    2016-01-01

    Motivation impairment is an often prominent component of schizophrenia symptomatology that impacts treatment engagement and reduces the functional benefit from psychosocial interventions. Intrinsic motivation in particular has been shown to be impaired in schizophrenia. Nowhere is the role of intrinsic motivation impairment more evident than in cognitive remediation for schizophrenia. This chapter describes the theoretical determinants of motivation to learn and illustrates how those determinants have been translated into therapeutic techniques that enhance intrinsic motivation in a clinical context. We review the extant research that indicates how motivation enhancing techniques yield treatment-related improvements within cognitive remediation therapy and, more broadly, in other behavioral skills-based interventions for schizophrenia.

  11. PREFACE: IV Nanotechnology International Forum (RUSNANOTECH 2011)

    Science.gov (United States)

    Dvurechenskii, Anatoly; Alfimov, Mikhail; Suzdalev, Igor; Osiko, Vyacheslav; Khokhlov, Aleksey; Son, Eduard; Skryabin, Konstantin; Petrov, Rem; Deev, Sergey

    2012-02-01

    Logo The RUSNANOTECH 2011 International Forum on Nanotechnology was held from 26-28 October 2011, in Moscow, Russia. It was the fourth forum organized by RUSNANO (Russian Corporation of Nanotechnologies) since 2008. In March 2011 RUSNANO was established as an open joint-stock company through the reorganization of the state corporation Russian Corporation of Nanotechnologies. RUSNANO's mission is to develop the Russian nanotechnology industry through co-investment in nanotechnology projects with substantial economic potential or social benefit. Within the framework of the Forum Science and Technology Program, presentations on key trends of nanotechnology development were given by foreign and Russian scientists, R&D officers of leading international companies, universities and scientific centers. The science and technology program of the Forum was divided into four sections as follows (by following hyperlinks you may find each section's program including videos of all oral presentations): Nanoelectronics and Nanophotonics Nanomaterials Nanotechnology and Green Energy Nanotechnology in Healthcare and Pharma (United business and science & technology section on 'RUSNANOTECH 2011') The scientific program of the forum included more than 50 oral presentations by leading scientists from 15 countries. Among them were world-known specialists such as Professor S Bader (Argonne National Laboratory, USA), Professor O Farokzhad (Harvard Medical School, USA), Professor K Chien (Massachusetts General Hospital, USA), Professor L Liz-Marzan (University of Vigo), A Luque (Polytechnic University of Madrid) and many others. The poster session consisted of over 120 presentations, 90 of which were presented in the framework of the young scientists' nanotechnology papers competition. This volume of Journal of Physics: Conference Series includes a selection of 47 submissions. Section editors of the proceedings: Nanoelectronics and nanophotonics Corresponding Member of Russian Academy of

  12. Impaired glutathione synthesis in schizophrenia

    DEFF Research Database (Denmark)

    Gysin, René; Kraftsik, Rudolf; Sandell, Julie

    2007-01-01

    Schizophrenia is a complex multifactorial brain disorder with a genetic component. Convergent evidence has implicated oxidative stress and glutathione (GSH) deficits in the pathogenesis of this disease. The aim of the present study was to test whether schizophrenia is associated with a deficit...... of GSH synthesis. Cultured skin fibroblasts from schizophrenia patients and control subjects were challenged with oxidative stress, and parameters of the rate-limiting enzyme for the GSH synthesis, the glutamate cysteine ligase (GCL), were measured. Stressed cells of patients had a 26% (P = 0.......002) decreased GCL activity as compared with controls. This reduction correlated with a 29% (P schizophrenia in two...

  13. Memory deficit in patients with schizophrenia and posttraumatic stress disorder: relational vs item-specific memory

    Directory of Open Access Journals (Sweden)

    Jung W

    2016-05-01

    Full Text Available Wookyoung Jung,1 Seung-Hwan Lee1,2 1Clinical Emotions and Cognition Research Laboratory, Department of Psychiatry, Inje University, Ilsan-Paik Hospital, 2Department of Psychiatry, Inje University, Ilsan-Paik Hospital, Goyang, Korea Abstract: It has been well established that patients with schizophrenia have impairments in cognitive functioning and also that patients who experienced traumatic events suffer from cognitive deficits. Of the cognitive deficits revealed in schizophrenia or posttraumatic stress disorder (PTSD patients, the current article provides a brief review of deficit in episodic memory, which is highly predictive of patients’ quality of life and global functioning. In particular, we have focused on studies that compared relational and item-specific memory performance in schizophrenia and PTSD, because measures of relational and item-specific memory are considered the most promising constructs for immediate tangible development of clinical trial paradigm. The behavioral findings of schizophrenia are based on the tasks developed by the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS initiative and the Cognitive Neuroscience Test Reliability and Clinical Applications for Schizophrenia (CNTRACS Consortium. The findings we reviewed consistently showed that schizophrenia and PTSD are closely associated with more severe impairments in relational memory compared to item-specific memory. Candidate brain regions involved in relational memory impairment in schizophrenia and PTSD are also discussed. Keywords: schizophrenia, posttraumatic stress disorder, episodic memory deficit, relational memory, item-specific memory, prefrontal cortex, hippocampus

  14. [Emotional Memory and Electrocortical Activity in Schizophrenia].

    Science.gov (United States)

    Lavoie, Marc E; Champagne, Julie; Glaser, Emma; Mendrek, Adrianna

    Context Abnormal emotion processing is frequent in schizophrenia and affects social and functional outcome. Past event-related potential (ERP) research investigating processing of affective stimuli in schizophrenia was done mainly with facial expressions and revealed impaired facial emotion recognition in patients relative to control subjects. Experimentations involving fMRI with this group of patients, showed alteration of limbic and frontal regions in response to emotional unpleasant images, compared to neutral stimuli during a memory task. Other studies have also noted an increase in brain activity when the activation of the stimuli was high compared to low arousal stimuli. This may indicate a different sensitivity threshold to emotional arousal and emotional valence involving frontal pathways in these patients. But very few studies attempted to separate the contributions of emotional valence and arousal within an episodic memory protocol with ERP, in that population.Goal The aim of the current research is to investigate brain electro-cortical activity in schizophrenia in response to emotional images during an episodic memory task.Method ERP components were analyzed in 16 schizophrenic and 17 control participants matched for age, sex and intelligence. ERPs were obtained from 56 EEG electrodes. The tasks consisted in a classical episodic memory task that presented 100 repeated old and 100 new photographic images divided into four categories (unpleasant-high arousal, unpleasant-low arousal, pleasant-high arousal and pleasant-low arousal) selected from the International Affective Picture System. The N200, P300 and late positive component (LPC) mean amplitude, were analyzed using repeated-measure analyses of variance (MANOVA).Results Patients with schizophrenia and control subjects gave comparable subjective evaluations of arousal and valence. However, the frontal N200 and the P300 both showed an interaction of the group x memory x valence x hemisphere (F [1

  15. Targeting Functional Biomarkers in Schizophrenia with Neuroimaging

    OpenAIRE

    Wylie, Korey P.; Smucny, Jason; Legget, Kristina T.; Tregellas, Jason R.

    2016-01-01

    Many of the most debilitating symptoms for psychiatric disorders such as schizophrenia remain poorly treated. As such, the development of novel treatments is urgently needed. Unfortunately, the costs associated with high failure rates for investigational compounds as they enter clinical trials has led to pharmaceutical companies downsizing or eliminating research programs needed to develop these drugs. One way of increasing the probability of success for investigational compounds is to incorp...

  16. Abstract Collection of 20th Forum: Third Package and Other Energy Directives

    International Nuclear Information System (INIS)

    2011-01-01

    This years' annual Forum is held twentieth year in a row. Numerous of important topics have been discussed during previous years, tracking all the changes in energy sector, from national monopoly utilities towards open markets, from first visions of consideration of renewable sources of energy towards the present realization of this facilities, from first identification of climate changes issues towards today's achievements in climate control. One could enumerate all the things that changed during this timeframe since it is a period when outlines of new energy policy and technological development were recognized. All these years this was an open space for presentation of ideas and discussions. This Forum hosted many remarkable experts which introduced us with global visions and expectations. In a way, Forum has been leader of changes, a kind of school for development of overall relations in energy sector, and around it. Forum was never a place where conclusions were brought. For some, it is a disadvantage, for us that are the basis of Forums' work, foreseen as a place where different ideas and solutions meet, but not a place for decision-making. Decision-making is foreseen for some other places, and from the profession expectation's point of view. It would be advisable to make those decisions based on the serious and thorough researches. Last 20 years have confirmed a need to continue tradition of the Forum. We hope that choice of new topics and experts will continue to bring new knowledge, experiences and reflections. We would like to continue on being an open space for all ideas that are able to contribute to strategic development of energy sector. (author)

  17. Molecular Risk Factors for Schizophrenia.

    Science.gov (United States)

    Modai, Shira; Shomron, Noam

    2016-03-01

    Schizophrenia (SZ) is a complex and strongly heritable mental disorder, which is also associated with developmental-environmental triggers. As opposed to most diagnosable diseases (yet similar to other mental disorders), SZ diagnosis is commonly based on psychiatric evaluations. Recently, large-scale genetic and epigenetic approaches have been applied to SZ research with the goal of potentially improving diagnosis. Increased computational analyses and applied statistical algorithms may shed some light on the complex genetic and epigenetic pathways contributing to SZ pathogenesis. This review discusses the latest advances in molecular risk factors and diagnostics for SZ. Approaches such as these may lead to a more accurate definition of SZ and assist in creating extended and reliable clinical diagnoses with the potential for personalized treatment. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. On incomprehensibility in schizophrenia

    DEFF Research Database (Denmark)

    Henriksen, Mads Gram

    2013-01-01

    the notion of understanding that deems these delusions incomprehensible and to see if it is possible to comprehend these delusions if we apply another notion of understanding. First, I discuss the contemporary schizophrenia definitions and their inherent problems, and I argue that the notion...... of incomprehensibility in these definitions rests heavily on Jaspers’ notions of understanding and empathy. Secondly, I discuss two Wittgensteinian attempts to comprehend bizarre delusions: (a) Campbell’s proposal to conceive delusions as framework propositions and (b) Sass’s suggestion to interpret delusions...... in the light of solipsism. Finally, I discuss the phenomenological conception of schizophrenia, which conceives delusion formation as resulting from alterations of the structure of experiencing and from underlying self-disorders. I argue that although a psychological understanding that seeks to grasp meaning...

  19. Epigenetic mechanisms in schizophrenia.

    Science.gov (United States)

    Akbarian, Schahram

    2014-09-01

    Schizophrenia is a major psychiatric disorder that lacks a unifying neuropathology, while currently available pharmacological treatments provide only limited benefits to many patients. This review will discuss how the field of neuroepigenetics could contribute to advancements of the existing knowledge on the neurobiology and treatment of psychosis. Genome-scale mapping of DMA methylation, histone modifications and variants, and chromosomal loopings for promoter-enhancer interactions and other epigenetic determinants of genome organization and function are likely to provide important clues about mechanisms contributing to dysregulated expression of synaptic and metabolic genes in schizophrenia brain, including the potential links to the underlying genetic risk architecture and environmental exposures. In addition, studies in animal models are providing a rapidly increasing list of chromatin-regulatory mechanisms with significant effects on cognition and complex behaviors, thereby pointing to the therapeutic potential of epigenetic drug targets in the nervous system.

  20. Token economy for schizophrenia.

    LENUS (Irish Health Repository)

    McMonagle, T

    2000-01-01

    A token economy is a behavioural therapy technique in which the desired change is achieved by means of tokens administered for the performance of predefined behaviours according to a program. Though token economy programmes were widespread in the 1970s they became largely restricted to wards where long-stay patients from institutions are prepared for transfer into the community and were particularly aimed at changing negative symptoms of schizophrenia - poor motivation, poor attention and social withdrawal.