Retinoblastoma-independent antiproliferative activity of novel intracellular antibodies against the E7 oncoprotein in HPV 16-positive cells

International Nuclear Information System (INIS)

Accardi, Luisa; Tommasino, Massimo; Banks, Lawrence; Chirullo, Barbara; Giorgi, Colomba; Donà, Maria Gabriella; Mileo, Anna M; Paggi, Marco G; Federico, Antonio; Torreri, Paola; Petrucci, Tamara C; Accardi, Rosita; Pim, David

2011-01-01

'High risk' Human Papillomavirus strains are the causative agents of the vast majority of carcinomas of the uterine cervix. In these tumors, the physical integration of the HPV genome is a frequent, though not invariable occurrence, but the constitutive expression of the E6 and E7 viral genes is always observed, suggesting key roles for the E6 and E7 oncoproteins in the process of malignant transformation. The 'intracellular antibody' technology using recombinant antibodies in single-chain format offers the possibility of targeting a protein in its intracellular environment even at the level of definite domains thus representing a valuable strategy to 'knock out' the function of specific proteins. In this study, we investigate the in vitro activity of two single-chain antibody fragments directed against the 'high-risk' HPV 16 E7 oncoprotein, scFv 43M2 and scFv 51. These scFvs were expressed by retroviral system in different cell compartments of the HPV16-positive SiHa cells, and cell proliferation was analyzed by Colony Formation Assay and EZ4U assay. The binding of these scFvs to E7, and their possible interference with the interaction between E7 and its main target, the tumor suppressor pRb protein, were then investigated by immunoassays, PepSet™technology and Surface Plasmon Resonance. The expression of the two scFvs in the nucleus and the endoplasmic reticulum of SiHa cells resulted in the selective growth inhibition of these cells. Analysis of binding showed that both scFvs bind E7 via distinct but overlapping epitopes not corresponding to the pRb binding site. Nevertheless, the binding of scFv 43M2 to E7 was inhibited by pRb in a non-competitive manner. Based on the overall results, the observed inhibition of HPV-positive SiHa cells proliferation could be ascribed to an interaction between scFv and E7, involving non-pRb targets. The study paves the way for the employment of specific scFvs in immunotherapeutic

Nurturing Good Ideas

NARCIS (Netherlands)

J.C.M. van den Ende (Jan); R.C. Kijkuit (Bob)

2009-01-01

textabstractManagers know that simply generating lots of ideas doesn’t necessarily produce good ones. What companies need are systems that nurture good ideas and cull bad ones—before they ever reach the decision maker’s desk. Our research shows that tapping the input of many people early in the

Doing Good Parenthood

DEFF Research Database (Denmark)

This edited collection shows that good parenthood is neither fixed nor stable. The contributors show how parenthood is equally done by men, women and children, in and through practices involving different normative guidelines. The book explores how normative layers of parenthood are constituted...... by notions such as good childhood, family ideals, national public health and educational strategies. The authors illustrate how different versions of parenthood coexist and how complex sets of actions are demanded to fulfil today’s expectations of parenthood in Western societies. This interdisciplinary book...

Generation of recombinant antibodies to rat GABAA receptor subunits by affinity selection on synthetic peptides.

Directory of Open Access Journals (Sweden)

Sujatha P Koduvayur

Full Text Available The abundance and physiological importance of GABAA receptors in the central nervous system make this neurotransmitter receptor an attractive target for localizing diagnostic and therapeutic biomolecules. GABAA receptors are expressed within the retina and mediate synaptic signaling at multiple stages of the visual process. To generate monoclonal affinity reagents that can specifically recognize GABAA receptor subunits, we screened two bacteriophage M13 libraries, which displayed human scFvs, by affinity selection with synthetic peptides predicted to correspond to extracellular regions of the rat α1 and β2 GABAA subunits. We isolated three anti-β2 and one anti-α1 subunit specific scFvs. Fluorescence polarization measurements revealed all four scFvs to have low micromolar affinities with their cognate peptide targets. The scFvs were capable of detecting fully folded GABAA receptors heterologously expressed by Xenopus laevis oocytes, while preserving ligand-gated channel activity. Moreover, A10, the anti-α1 subunit-specific scFv, was capable of detecting native GABAA receptors in the mouse retina, as observed by immunofluorescence staining. In order to improve their apparent affinity via avidity, we dimerized the A10 scFv by fusing it to the Fc portion of the IgG. The resulting scFv-Fc construct had a Kd of ∼26 nM, which corresponds to an approximately 135-fold improvement in binding, and a lower detection limit in dot blots, compared to the monomeric scFv. These results strongly support the use of peptides as targets for generating affinity reagents to membrane proteins and encourage investigation of molecular conjugates that use scFvs as anchoring components to localize reagents of interest at GABAA receptors of retina and other neural tissues, for studies of receptor activation and subunit structure.

Inhibition of protease-inhibitor resistant hepatitis C virus replicons and infectious virus by intracellular intrabodies

OpenAIRE

Gal-Tanamy, Meital; Zemel, Romy; Bachmatov, Larissa; Jangra, Rohit K.; Shapira, Assaf; Villanueva, Rodrigo; Yi, MinKyung; Lemon, Stanley M.; Benhar, Itai; Tur-Kaspa, Ran

2010-01-01

Hepatitis C virus (HCV) infection is a common cause of chronic liver disease and a serious threat to human health. The HCV NS3/4A serine protease is necessary for viral replication and innate immune evasion, and represents a well-validated target for specific antiviral therapy. We previously reported the isolation of single-chain antibodies (scFvs) that inhibit NS3/4A protease activity in vitro. Expressed intracellularly (intrabodies), these scFvs blocked NS3-mediated proliferation of NS3-tra...

ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo.

Science.gov (United States)

Spencer, Brian; Emadi, Sharareh; Desplats, Paula; Eleuteri, Simona; Michael, Sarah; Kosberg, Kori; Shen, Jay; Rockenstein, Edward; Patrick, Christina; Adame, Anthony; Gonzalez, Tania; Sierks, Michael; Masliah, Eliezer

2014-10-01

Parkinson's disease and dementia with Lewy bodies are neurodegenerative disorders characterized by accumulation of α-synuclein (α-syn). Recently, single-chain fragment variables (scFVs) have been developed against individual conformational species of α-syn. Unlike more traditional monoclonal antibodies, these scFVs will not activate or be endocytosed by Fc receptors. For this study, we investigated an scFV directed against oligomeric α-syn fused to the LDL receptor-binding domain from apolipoprotein B (apoB). The modified scFV showed enhanced brain penetration and was imported into neuronal cells through the endosomal sorting complex required for transport (ESCRT) pathway, leading to lysosomal degradation of α-syn aggregates. Further analysis showed that the scFV was effective at ameliorating neurodegenerative pathology and behavioral deficits observed in the mouse model of dementia with Lewy bodies/Parkinson's disease. Thus, the apoB modification had the effect of both increasing accumulation of the scFV in the brain and directing scFV/α-syn complexes for degradation through the ESCRT pathway, leading to improved therapeutic potential of immunotherapy.

Isolation of scFv antibody fragments against HER2 and CEA tumor antigens from combinatorial antibody libraries derived from cancer patients.

Science.gov (United States)

Ayat, Hoda; Burrone, Oscar R; Sadghizadeh, Majid; Jahanzad, Eissa; Rastgou, Nasrin; Moghadasi, Sarrira; Arbabi, Mehdi

2013-11-01

Tumor cells expressing HER-2/neu and CEA antigens are potentially ideal targets for antibody-targeted therapy. In this study, two large human combinatorial libraries have been generated from the lymph nodes of breast cancer patients that express HER2 and CEA antigens in their tumors. These 'immune' libraries have been constructed in two different formats of scFv, differing in the length of the peptide linker connecting the two variable VH and VL domains. Libraries derived from these patients may contain a larger pool of anti-tumor antigen antibodies and are useful repertoire for isolating scFvs against any tumor markers. The results of this study showed that we were successful in obtaining human scFvs against HER-2/neu and CEA. For HER-2, cell-panning strategy was performed and resulted in two scFv binders that detected the complete HER-2 receptor on the cell membrane and internalized to the cells. Also, preliminary ELISA data showed that several anti-CEA scFv binders were isolated by panning. Copyright © 2013 The International Alliance for Biological Standardization. All rights reserved.

Inhibition of protease-inhibitor resistant hepatitis C virus replicons and infectious virus by intracellular intrabodies

Science.gov (United States)

Gal-Tanamy, Meital; Zemel, Romy; Bachmatov, Larissa; Jangra, Rohit K.; Shapira, Assaf; Villanueva, Rodrigo; Yi, MinKyung; Lemon, Stanley M.; Benhar, Itai; Tur-Kaspa, Ran

2015-01-01

Hepatitis C virus (HCV) infection is a common cause of chronic liver disease and a serious threat to human health. The HCV NS3/4A serine protease is necessary for viral replication and innate immune evasion, and represents a well-validated target for specific antiviral therapy. We previously reported the isolation of single-chain antibodies (scFvs) that inhibit NS3/4A protease activity in vitro. Expressed intracellularly (intrabodies), these scFvs blocked NS3-mediated proliferation of NS3-transfected cells. Here we show that anti-NS3 scFvs suppress HCV RNA replication when expressed intracellularly in Huh7 hepatoma cells bearing either subgenomic or genome-length HCV RNA replicons. The expression of intrabodies directed against NS3 inhibited the autonomous amplification of HCV replicons resistant to small molecule inhibitors of the NS3/4A protease, and replicons derived from different HCV genotypes. The combination of intrabodies and interferon-α had an additive inhibitory effect on RNA replication in the replicon model. Intrabody expression also inhibited production of infectious HCV in a cell culture system. The NS3 protease activity was inhibited by the intrabodies in NS3-expressing cells. In contrast, cell-free synthesis of HCV RNA by preformed replicase complexes was not inhibited by intrabodies, suggesting that the major mode of inhibition of viral replication is inhibition of NS3/4A protease activity and subsequent suppression of viral polyprotein processing. PMID:20705106

Good Faith and Game Theory

DEFF Research Database (Denmark)

Rose, Caspar

2016-01-01

This article shows how game theory can be applied to model good faith mathematically using an example of a classic legal dispute related to rei vindicato. The issue is whether an owner has a legal right to his good if a person has bought it in good faith by using updated probabilities. The article...

Good leadership for good quality

OpenAIRE

Franzon, Vilma Maria

2016-01-01

Good leadership is important if you like to have high quality in the results. My experience in the production of the television industry is that conditions for good leadership is insufficient. Therefore, I have tried to get answers for those two questions in my exam report: What are the characteristics of good leadership? What are the prerequisites for good leadership out of production? The method I used is a literature study and observation. I have read a number of books and research studies...

Single chain variable fragment antibodies block aggregation and toxicity induced by familial ALS-linked mutant forms of SOD1.

Science.gov (United States)

Ghadge, Ghanashyam D; Pavlovic, John D; Koduvayur, Sujatha P; Kay, Brian K; Roos, Raymond P

2013-08-01

Approximately 10% of amyotrophic lateral sclerosis (ALS) cases are familial (known as FALS) with an autosomal dominant inheritance pattern, and ~25% of FALS cases are caused by mutations in Cu/Zn superoxide dismutase (SOD1). There is convincing evidence that mutant SOD1 (mtSOD1) kills motor neurons (MNs) because of a gain-of-function toxicity, most likely related to aggregation of mtSOD1. A number of recent reports have suggested that antibodies can be used to treat mtSOD1-induced FALS. To follow up on the use of antibodies as potential therapeutics, we generated single chain fragments of variable region antibodies (scFvs) against SOD1, and then expressed them as 'intrabodies' within a motor neuron cell line. In the present study, we describe isolation of human scFvs that interfere with mtSOD1 in vitro aggregation and toxicity. These scFvs may have therapeutic potential in sporadic ALS, as well as FALS, given that sporadic ALS may also involve abnormalities in the SOD1 protein or activity. Copyright © 2013 Elsevier Inc. All rights reserved.

Site-Specific Antibody Functionalization Using Tetrazine-Styrene Cycloaddition.

Science.gov (United States)

Umlauf, Benjamin J; Mix, Kalie A; Grosskopf, Vanessa A; Raines, Ronald T; Shusta, Eric V

2018-05-03

Biologics, such as antibody-drug conjugates, are becoming mainstream therapeutics. Consequently, methods to functionalize biologics without disrupting their native properties are essential for identifying, characterizing, and translating candidate biologics from the bench to clinical practice. Here, we present a method for site-specific, carboxy-terminal modification of single-chain antibody fragments (scFvs). ScFvs displayed on the surface of yeast were isolated and functionalized by combining intein-mediated expressed protein ligation (EPL) with inverse electron-demand Diels-Alder (IEDDA) cycloaddition using a styrene-tetrazine pair. The high thiol concentration required to trigger EPL can hinder the subsequent chemoselective ligation reactions; therefore, the EPL reaction was used to append styrene to the scFv, limiting tetrazine exposure to damaging thiols. Subsequently, the styrene-functionalized scFv was reacted with tetrazine-conjugated compounds in an IEDDA cycloaddition to generate functionalized scFvs that retain their native binding activity. Rapid functionalization of yeast surface-derived scFv in a site-directed manner could find utility in many downstream laboratory and preclinical applications.

"Everyone just ate good food": 'Good food' in Islamabad, Pakistan.

Science.gov (United States)

Hasnain, Saher

2018-08-01

In recent years, consumption of alternatively produced foods has increased in popularity in response to the deleterious effects of rapidly globalising and industrialised food systems. Concerns over food safety in relation to these changes may result from elevated levels of risk and changing perceptions associated with food production practices. This paper explores how the middle class residents of Islamabad, Pakistan, use the concept of 'good food' to reconnect themselves with nature, changing food systems, and traditional values. The paper also demonstrates how these ideas relate to those of organic, local, and traditional food consumption as currently used in more economically developed states in the Global North. Through research based on participant observation and semi-structured interviews, this paper illustrates that besides price and convenience, purity, freshness, association with specific places, and 'Pakistani-ness' were considered as the basis for making decisions about 'good food'. The results show that while individuals are aware of and have some access to imported organic and local food, they prefer using holistic and culturally informed concepts of 'good food' instead that reconnect them with food systems. I argue that through conceptualisations of 'good food', the urban middle class in Islamabad is reducing their disconnection and dis-embeddedness from nature, the food systems, and their social identities. The paper contributes to literature on food anxieties, reconnections in food geography, and 'good food' perceptions, with a focus on Pakistan. Copyright © 2018. Published by Elsevier Ltd.

Design and Generation of Humanized Single-chain Fv Derived from Mouse Hybridoma for Potential Targeting Application.

Science.gov (United States)

Khantasup, Kannika; Chantima, Warangkana; Sangma, Chak; Poomputsa, Kanokwan; Dharakul, Tararaj

2015-12-01

Single-chain variable antibody fragments (scFvs) are attractive candidates for targeted immunotherapy in several human diseases. In this study, a concise humanization strategy combined with an optimized production method for humanizing scFvs was successfully employed. Two antibody clones, one directed against the hemagglutinin of H5N1 influenza virus, the other against EpCAM, a cancer biomarker, were used to demonstrate the validity of the method. Heavy chain (VH) and light chain (VL) variable regions of immunoglobulin genes from mouse hybridoma cells were sequenced and subjected to the construction of mouse scFv 3-D structure. Based on in silico modeling, the humanized version of the scFv was designed via complementarity-determining region (CDR) grafting with the retention of mouse framework region (FR) residues identified by primary sequence analysis. Root-mean-square deviation (RMSD) value between mouse and humanized scFv structures was calculated to evaluate the preservation of CDR conformation. Mouse and humanized scFv genes were then constructed and expressed in Escherichia coli. Using this method, we successfully generated humanized scFvs that retained the targeting activity of their respective mouse scFv counterparts. In addition, the humanized scFvs were engineered with a C-terminal cysteine residue (hscFv-C) for site-directed conjugation for use in future targeting applications. The hscFv-C expression was extensively optimized to improve protein production yield. The protocol yielded a 20-fold increase in production of hscFv-Cs in E. coli periplasm. The strategy described in this study may be applicable in the humanization of other antibodies derived from mouse hybridoma.

Is electricity a public good?

International Nuclear Information System (INIS)

Salies, Evens; Kiesling, Lynne; Giberson, Michael

2007-04-01

Wholesale electricity markets are increasingly driven by the rules of competition while recent outages in different regions of the world suggest that security of supply is a public good. The objective of this paper is to show that security of supply and more generally, electricity supply has both public and private characteristics. Whilst the public good characteristic explains why some producers may prefer to free ride on others' investments to maintain reliability, the private good aspect of reliability shows that agents may have a variety of preferences for reliability. Then by relying on the concept of Pareto-relevant externality, the paper explores the private aspect of reliability for the prospect of creating and selling reliability as a differentiated product complementary to bulk power markets. Finally, policy recommendations are derived that aim to enhance information content in the network. Initially published in 'Revue de l'OFCE' No. 101

Rise and Fall of an Anti-MUC1 Specific Antibody

Science.gov (United States)

Li, Jiandong; von Wasielewski, Reinhard; Bastert, Gunther; Schirrmann, Thomas; Esteves, Isabel Tourais; Behrens, Christian K.; Fournes, Bénédict; Fournier, Nathalie; de Romeuf, Christophe; Hust, Michael; Dübel, Stefan

2011-01-01

Background So far, human antibodies with good affinity and specificity for MUC1, a transmembrane protein overexpressed on breast cancers and ovarian carcinomas, and thus a promising target for therapy, were very difficult to generate. Results A human scFv antibody was isolated from an immune library derived from breast cancer patients immunised with MUC1. The anti-MUC1 scFv reacted with tumour cells in more than 80% of 228 tissue sections of mamma carcinoma samples, while showing very low reactivity with a large panel of non-tumour tissues. By mutagenesis and phage display, affinity of scFvs was increased up to 500fold to 5,7×10−10 M. Half-life in serum was improved from below 1 day to more than 4 weeks and was correlated with the dimerisation tendency of the individual scFvs. The scFv bound to T47D and MCF-7 mammalian cancer cell lines were recloned into the scFv-Fc and IgG format resulting in decrease of affinity of one binder. The IgG variants with the highest affinity were tested in mouse xenograft models using MCF-7 and OVCAR tumour cells. However, the experiments showed no significant decrease in tumour growth or increase in the survival rates. To study the reasons for the failure of the xenograft experiments, ADCC was analysed in vitro using MCF-7 and OVCAR3 target cells, revealing a low ADCC, possibly due to internalisation, as detected for MCF-7 cells. Conclusions Antibody phage display starting with immune libraries and followed by affinity maturation is a powerful strategy to generate high affinity human antibodies to difficult targets, in this case shown by the creation of a highly specific antibody with subnanomolar affinity to a very small epitope consisting of four amino acids. Despite these “best in class” binding parameters, the therapeutic success of this antibody was prevented by the target biology. PMID:21264246

Rise and fall of an anti-MUC1 specific antibody.

Directory of Open Access Journals (Sweden)

Holger Thie

2011-01-01

Full Text Available So far, human antibodies with good affinity and specificity for MUC1, a transmembrane protein overexpressed on breast cancers and ovarian carcinomas, and thus a promising target for therapy, were very difficult to generate.A human scFv antibody was isolated from an immune library derived from breast cancer patients immunised with MUC1. The anti-MUC1 scFv reacted with tumour cells in more than 80% of 228 tissue sections of mamma carcinoma samples, while showing very low reactivity with a large panel of non-tumour tissues. By mutagenesis and phage display, affinity of scFvs was increased up to 500fold to 5,7×10(-10 M. Half-life in serum was improved from below 1 day to more than 4 weeks and was correlated with the dimerisation tendency of the individual scFvs. The scFv bound to T47D and MCF-7 mammalian cancer cell lines were recloned into the scFv-Fc and IgG format resulting in decrease of affinity of one binder. The IgG variants with the highest affinity were tested in mouse xenograft models using MCF-7 and OVCAR tumour cells. However, the experiments showed no significant decrease in tumour growth or increase in the survival rates. To study the reasons for the failure of the xenograft experiments, ADCC was analysed in vitro using MCF-7 and OVCAR3 target cells, revealing a low ADCC, possibly due to internalisation, as detected for MCF-7 cells.Antibody phage display starting with immune libraries and followed by affinity maturation is a powerful strategy to generate high affinity human antibodies to difficult targets, in this case shown by the creation of a highly specific antibody with subnanomolar affinity to a very small epitope consisting of four amino acids. Despite these "best in class" binding parameters, the therapeutic success of this antibody was prevented by the target biology.

Determination of allergen specificity by heavy chains in grass pollen allergen-specific IgE antibodies.

Science.gov (United States)

Gadermaier, Elisabeth; Flicker, Sabine; Lupinek, Christian; Steinberger, Peter; Valenta, Rudolf

2013-04-01

Affinity and clonality of allergen-specific IgE antibodies are important determinants for the magnitude of IgE-mediated allergic inflammation. We sought to analyze the contribution of heavy and light chains of human allergen-specific IgE antibodies for allergen specificity and to test whether promiscuous pairing of heavy and light chains with different allergen specificity allows binding and might affect affinity. Ten IgE Fabs specific for 3 non-cross-reactive major timothy grass pollen allergens (Phl p 1, Phl p 2, and Phl p 5) obtained by means of combinatorial cloning from patients with grass pollen allergy were used to construct stable recombinant single chain variable fragments (ScFvs) representing the original Fabs and shuffled ScFvs in which heavy chains were recombined with light chains from IgE Fabs with specificity for other allergens by using the pCANTAB 5 E expression system. Possible ancestor genes for the heavy chain and light chain variable region-encoding genes were determined by using sequence comparison with the ImMunoGeneTics database, and their chromosomal locations were determined. Recombinant ScFvs were tested for allergen specificity and epitope recognition by means of direct and sandwich ELISA, and affinity by using surface plasmon resonance experiments. The shuffling experiments demonstrate that promiscuous pairing of heavy and light chains is possible and maintains allergen specificity, which is mainly determined by the heavy chains. ScFvs consisting of different heavy and light chains exhibited different affinities and even epitope specificity for the corresponding allergen. Our results indicate that allergen specificity of allergen-specific IgE is mainly determined by the heavy chains. Different heavy and light chain pairings in allergen-specific IgE antibodies affect affinity and epitope specificity and thus might influence clinical reactivity to allergens. Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by

The generalized good cut equation

International Nuclear Information System (INIS)

Adamo, T M; Newman, E T

2010-01-01

The properties of null geodesic congruences (NGCs) in Lorentzian manifolds are a topic of considerable importance. More specifically NGCs with the special property of being shear-free or asymptotically shear-free (as either infinity or a horizon is approached) have received a great deal of recent attention for a variety of reasons. Such congruences are most easily studied via solutions to what has been referred to as the 'good cut equation' or the 'generalization good cut equation'. It is the purpose of this paper to study these equations and show their relationship to each other. In particular we show how they all have a four-complex-dimensional manifold (known as H-space, or in a special case as complex Minkowski space) as a solution space.

Gravity with Intermediate Goods Trade

Directory of Open Access Journals (Sweden)

Sujin Jang

2017-12-01

Full Text Available This paper derives the gravity equation with intermediate goods trade. We extend a standard monopolistic competition model to incorporate intermediate goods trade, and show that the gravity equation with intermediates trade is identical to the one without it except in that gross output should be used as the output measure instead of value added. We also show that the output elasticity of trade is significantly underestimated when value added is used as the output measure. This implies that with the conventional gravity equation, the contribution of output growth can be substantially underestimated and the role of trade costs reduction can be exaggerated in explaining trade expansion, as we demonstrate for the case of Korea's trade growth between 1995 and 2007.

Framing and misperceptions in a public good experiment

DEFF Research Database (Denmark)

Fosgaard, Toke; Hansen, Lars Gårn; Wengström, Erik Roland

Earlier studies have found that a substantial part of the contributions in public good games can be explained by subjects misperceiving the game's incentives. Using a large-scale public good experiment, we show that subtle changes in how the game is framed substantially affect such misperceptions...... and that this explains major parts of framing effect on subjects' behavior. When controlling for the different levels of misperception between frames, the framing effect on subjects' cooperation preferences disappears.......Earlier studies have found that a substantial part of the contributions in public good games can be explained by subjects misperceiving the game's incentives. Using a large-scale public good experiment, we show that subtle changes in how the game is framed substantially affect such misperceptions...

8 CFR 274a.4 - Good faith defense.

Science.gov (United States)

2010-01-01

... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Good faith defense. 274a.4 Section 274a.4... ALIENS Employer Requirements § 274a.4 Good faith defense. An employer or a recruiter or referrer for a fee for employment who shows good faith compliance with the employment verification requirements of...

A Strategy for Generating a Broad-Spectrum Monoclonal Antibody and Soluble Single-Chain Variable Fragments against Plant Potyviruses

Science.gov (United States)

Liu, Han-Lin; Lin, Wei-Fang; Hu, Wen-Chi; Lee, Yung-An

2015-01-01

Potyviruses are major pathogens that often cause mixed infection in calla lilies. To reduce the time and cost of virus indexing, a detection method for the simultaneous targeting of multiple potyviruses was developed by generating a broad-spectrum monoclonal antibody (MAb) for detecting the greatest possible number of potyviruses. The conserved 121-amino-acid core regions of the capsid proteins of Dasheen mosaic potyvirus (DsMV), Konjak mosaic potyvirus (KoMV), and Zantedeschia mild mosaic potyvirus (ZaMMV) were sequentially concatenated and expressed as a recombinant protein for immunization. After hybridoma cell fusion and selection, one stable cell line that secreted a group-specific antibody, named C4 MAb, was selected. In the reaction spectrum test, the C4 MAb detected at least 14 potyviruses by indirect enzyme-linked immunosorbent assay (I-ELISA) and Western blot analysis. Furthermore, the variable regions of the heavy (VH) and light (VL) chains of the C4 MAb were separately cloned and constructed as single-chain variable fragments (scFvs) for expression in Escherichia coli. Moreover, the pectate lyase E (PelE) signal peptide of Erwinia chrysanthemi S3-1 was added to promote the secretion of C4 scFvs into the medium. According to Western blot analysis and I-ELISA, the soluble C4 scFv (VL-VH) fragment showed a binding specificity similar to that of the C4 MAb. Our results demonstrate that a recombinant protein derived from fusion of the conserved regions of viral proteins has the potential to produce a broad-spectrum MAb against a large group of viruses and that the PelE signal peptide can improve the secretion of scFvs in E. coli. PMID:26209665

Antiproliferative and apoptotic effects of a specific anti-insulin-like growth factor I receptor single chain antibody on breast cancer cells.

Science.gov (United States)

Motallebnezhad, Morteza; Younesi, Vahid; Aghebati-Maleki, Leili; Nickho, Hamid; Safarzadeh, Elham; Ahmadi, Majid; Movassaghpour, Ali Akbar; Hosseini, Ahmad; Yousefi, Mehdi

2016-11-01

Insulin-like growth factor I receptor (IGF-IR) is expressed on breast cancer cells and involves in metastasis, survival, and proliferation. Currently, application of IGF-IR-targeting monoclonal antibodies (mAbs), alone or in combination with other drugs, is a promising strategy for breast cancer therapy. Single-chain fragment variable (scFv) antibodies have been introduced as appropriate tools for tumor-targeting purposes because of their advantages over whole antibodies. In the present study, we employed a naïve phage library and isolated scFvs against a specific epitope from extracellular domain of IGF-IR by panning process. The selected scFvs were further characterized using polyclonal and monoclonal phage ELISA, soluble monoclonal ELISA, and colony PCR and sequencing. Antiproliferative and apoptotic effects of selected scFv antibodies on breast cancer cell lines were also evaluated by MTT and Annexin V/PI assays. The results of ELISA indicated specific reactions of the isolated scFvs against the IGF-IR peptide, and analyses of PCR product and sequencing confirmed the presence of full length V H and Vκ inserts. Treatment of MCF7 and SKBR3 cells with anti-IGF-IR scFv led to a significant growth inhibition. The results also showed that scFv treatment significantly augmented trastuzumab growth inhibitory effects on SKBR3 cells. The percentage of the apoptotic MCF7 and SKBR3 cells after 24-h treatment with scFv was 39 and 30.70 %, respectively. Twenty-four-hour treatment with scFv in combination with trastuzumab resulted in 44.75 % apoptosis of SKBR3 cells. Taken together, our results demonstrate that the targeting of IGF-IR by scFv can be an effective strategy in the treatment of breast cancer and provide further evidence for effectiveness of dual targeting of HER2 and IGF-IR in breast cancer therapy.

Targeting the active site of the placental isozyme of alkaline phosphatase by phage-displayed scFv antibodies selected by a specific uncompetitive inhibitor

Directory of Open Access Journals (Sweden)

Kala Mrinalini

2005-12-01

Full Text Available Abstract Background The isozymes of alkaline phosphatase, the tissue non-specific, intestinal and placental, have similar properties and a high degree of identity. The placental isozyme (PLAP is an oncofetal antigen expressed in several malignancies including choriocarcinoma, seminoma and ovarian carcinoma. We had earlier attempted to isolate PLAP-specific scFv from a synthetic human immunoglobulin library but were unable to do so, presumably because of the similarity between the isozymes. In this work, we have employed a PLAP-specific uncompetitive inhibitor, L-Phe-Gly-Gly, to select isozyme specific scFvs. An uncompetitive inhibitor binds to the enzyme in the presence of substrate and stabilizes the enzyme-substrate complex. Several uncompetitive inhibitors have varying degrees of isozyme specificity for human alkaline phosphatase isozymes. A specific uncompetitive inhibitor would be able to unmask conformational differences between the otherwise very similar molecules. Also, such inhibitors would be directed to regions at/close to the active site of the enzyme. In this work, the library was first incubated with PLAP and the bound clones then eluted by incubation with L-Phe-Gly-Gly along with the substrate, para-nitro phenyl phosphate (pNPP. The scFvs were then studied with regard to the biochemical modulation of their binding, isozyme specificity and effect on enzyme activity. Results Of 13 clones studied initially, the binding of 9 was inhibited by L-Phe-Gly-Gly (with pNPP and 2 clones were inhibited by pNPP alone. Two clones had absolute and 2 clones had partial specificity to PLAP. Two clones were cross-reactive with only one other isozyme. Three scFv clones, having an accessible His6-tag, were purified and studied for their modulation of enzyme activity. All the three scFvs inhibited PLAP activity with the kinetics of competitive inhibition. Cell ELISA could demonstrate binding of the specific scFvs to the cell surface expressed PLAP

Evaluating e-Government and Good Governance Correlation

Directory of Open Access Journals (Sweden)

Suhardi Suhardi

2016-03-01

Full Text Available Assessing the achievement of Indonesian government institutions in implementing e-government has been conducted since around a decade ago. Several national assessments are available with almost the same ranking results. There is an agreement that the ultimate goal of e-government implementation is to achieve good government governance (GGG, while success stories of e-government require good governance practices. This study explored the correlation between e-government achievement and GGG achievement in Indonesia. Spearman’s rank correlation was used to characterize the relationship strength between e-government assessment results and good governance assessment results. The data were collected from institutions that participated in e-government and good governance assessments. The results showed that the correlation between these two entities is not very strong. Most cases showed that e-government implementation and the achievement of good governance have only a moderate positive correlation and none of the studied cases indicated a significant connection. This result can be attributed to the lack of emphasis on goals achievement in the assessments. Thus, it is recommended that future Indonesian e-government assessments should involve impact indicators.

Good soldiers and good actors: prosocial and impression management motives as interactive predictors of affiliative citizenship behaviors.

Science.gov (United States)

Grant, Adam M; Mayer, David M

2009-07-01

Researchers have discovered inconsistent relationships between prosocial motives and citizenship behaviors. We draw on impression management theory to propose that impression management motives strengthen the association between prosocial motives and affiliative citizenship by encouraging employees to express citizenship in ways that both "do good" and "look good." We report 2 studies that examine the interactions of prosocial and impression management motives as predictors of affiliative citizenship using multisource data from 2 different field samples. Across the 2 studies, we find positive interactions between prosocial and impression management motives as predictors of affiliative citizenship behaviors directed toward other people (helping and courtesy) and the organization (initiative). Study 2 also shows that only prosocial motives predict voice-a challenging citizenship behavior. Our results suggest that employees who are both good soldiers and good actors are most likely to emerge as good citizens in promoting the status quo.

Substantial Goodness and Nascent Human Life.

Science.gov (United States)

Floyd, Shawn

2015-09-01

Many believe that moral value is--at least to some extent--dependent on the developmental states necessary for supporting rational activity. My paper rejects this view, but does not aim simply to register objections to it. Rather, my essay aims to answer the following question: if a human being's developmental state and occurrent capacities do not bequeath moral standing, what does? The question is intended to prompt careful consideration of what makes human beings objects of moral value, dignity, or (to employ my preferred term) goodness. Not only do I think we can answer this question, I think we can show that nascent human life possesses goodness of precisely this sort. I appeal to Aquinas's metaethics to establish the conclusion that the goodness of a human being--even if that being is an embryo or fetus--resides at the substratum of her existence. If she possesses goodness, it is because human existence is good.

Optimal Provision of Public Goods

DEFF Research Database (Denmark)

Kreiner, Claus Thustrup; Verdelin, Nicolaj

2012-01-01

The standard approach to the optimal provision of public goods highlights the importance of distortionary taxation and distributional concerns. A new approach neutralizes distributional concerns by adjusting the income tax schedule. We demonstrate that both approaches are derived from the same...... basic formula. We also take the new approach further by deriving an intuitive formula for the optimal level of public goods, without imposing strong assumptions on preferences. This formula shows that distortionary taxation has a role to play, as in the standard approach. However, the main determinants...

Optimal Provision of Public Goods

DEFF Research Database (Denmark)

Kreiner, Claus Thustrup; Verdelin, Nicolaj

2009-01-01

There currently exist two competing approaches in the literature on the optimal provision of public goods. The standard approach highlights the importance of distortionary taxation and distributional concerns. The new approach neutralizes distributional concerns by adjusting the non-linear income...... for the optimal level of a public good without imposing strong assumptions on preferences. This formula shows that distortionary taxation may have a role to play as in the standard approach. However, the main determinants of optimal provision are completely different and the traditional formula with its emphasis...

HOW GOOD IS GOODS AND SERVICES TAX

OpenAIRE

Dr. Sreemoyee Guha Roy

2016-01-01

Goods and Services Tax is a broad based and a single comprehensive tax levied on goods and services consumed in an economy. GST is levied at every stage of the production-distribution chain with applicable set offs in respect of the tax remitted at previous stages. It is basically a tax on final consumption. The Goods and Services Tax (GST) is a value added tax to be implemented in India, the decision on which is pending. GST is the only indirect tax that directly affects all sectors and sect...

Framing and misperception in public good experiments

DEFF Research Database (Denmark)

Fosgaard, Toke Reinholt; Hansen, Lars Gårn; Wengström, Erik Roland

2017-01-01

Earlier studies have found that framing has substantial impact on the degree of cooperation observed in public good experiments. We show that the way the public good game is framed affects misperceptions about the incentives of the game. Moreover, we show that such framing-induced differences...... in misperceptions are linked to the framing effect on subjects' cooperation behavior. When we do not control for the different levels of misperceptions between frames, we observe a significant framing effect on subjects’ cooperation preferences. However, this framing effect becomes insignificant once we remove...

The Messiness of Common Good

DEFF Research Database (Denmark)

Feldt, Liv Egholm

Civil society and its philanthropic and voluntary organisations are currently experiencing public and political attention and demands to safeguard society’s ‘common good’ through social cohesion and as providers of welfare services. This has raised the question by both practitioners and researchers...... that a distinction between the non-civil and the civil is more fruitful, if we want to understand the past, present and future messiness in place in defining the common good. Based on an ethnographic case analysis of a Danish corporate foundation between 1920 and 2014 the paper shows how philanthropic gift......-giving concepts, practices and operational forms throughout history have played a significant role in defining the common good and its future avenues. Through an analytical attitude based on microhistory, conceptual history and the sociology of translation it shows that civil society’s institutional logic always...

It’s good to do good and receive good: The impact of a ‘pay it forward’ style kindness intervention on giver and receiver well-being

OpenAIRE

Pressman, SD; Kraft, TL; Cross, MP

2015-01-01

© 2014 Taylor & Francis. Despite the popularity of the ‘pay it forward’ (PIF) concept in textbooks and popular culture, to date, no study has tested the effectiveness of a brief, one-time PIF activity on the well-being of those who do good and those who receive good. To test this, 83 undergraduates (‘givers’) performed random kind acts for 1.5 h. PIF resulted in a wide range of well-being benefits for givers (e.g. greater positive and lower negative affect), with females showing greater pos...

Generation of human antibody fragments recognizing distinct epitopes of the nucleocapsid (N SARS-CoV protein using a phage display approach

Directory of Open Access Journals (Sweden)

Grasso Felicia

2005-09-01

Full Text Available Abstract Background Severe acute respiratory syndrome (SARS-CoV is a newly emerging virus that causes SARS with high mortality rate in infected people. Successful control of the global SARS epidemic will require rapid and sensitive diagnostic tests to monitor its spread, as well as, the development of vaccines and new antiviral compounds including neutralizing antibodies that effectively prevent or treat this disease. Methods The human synthetic single-chain fragment variable (scFv ETH-2 phage antibody library was used for the isolation of scFvs against the nucleocapsid (N protein of SARS-CoV using a bio panning-based strategy. The selected scFvs were characterized under genetics-molecular aspects and for SARS-CoV N protein detection in ELISA, western blotting and immunocytochemistry. Results Human scFv antibodies to N protein of SARS-CoV can be easily isolated by selecting the ETH-2 phage library on immunotubes coated with antigen. These in vitro selected human scFvs specifically recognize in ELISA and western blotting studies distinct epitopes in N protein domains and detect in immunohistochemistry investigations SARS-CoV particles in infected Vero cells. Conclusion The human scFv antibodies isolated and described in this study represent useful reagents for rapid detection of N SARS-CoV protein and SARS virus particles in infected target cells.

Climatic associations of British species distributions show good transferability in time but low predictive accuracy for range change.

Directory of Open Access Journals (Sweden)

Giovanni Rapacciuolo

Full Text Available Conservation planners often wish to predict how species distributions will change in response to environmental changes. Species distribution models (SDMs are the primary tool for making such predictions. Many methods are widely used; however, they all make simplifying assumptions, and predictions can therefore be subject to high uncertainty. With global change well underway, field records of observed range shifts are increasingly being used for testing SDM transferability. We used an unprecedented distribution dataset documenting recent range changes of British vascular plants, birds, and butterflies to test whether correlative SDMs based on climate change provide useful approximations of potential distribution shifts. We modelled past species distributions from climate using nine single techniques and a consensus approach, and projected the geographical extent of these models to a more recent time period based on climate change; we then compared model predictions with recent observed distributions in order to estimate the temporal transferability and prediction accuracy of our models. We also evaluated the relative effect of methodological and taxonomic variation on the performance of SDMs. Models showed good transferability in time when assessed using widespread metrics of accuracy. However, models had low accuracy to predict where occupancy status changed between time periods, especially for declining species. Model performance varied greatly among species within major taxa, but there was also considerable variation among modelling frameworks. Past climatic associations of British species distributions retain a high explanatory power when transferred to recent time--due to their accuracy to predict large areas retained by species--but fail to capture relevant predictors of change. We strongly emphasize the need for caution when using SDMs to predict shifts in species distributions: high explanatory power on temporally-independent records

The risk of bias in systematic reviews tool showed fair reliability and good construct validity.

Science.gov (United States)

Bühn, Stefanie; Mathes, Tim; Prengel, Peggy; Wegewitz, Uta; Ostermann, Thomas; Robens, Sibylle; Pieper, Dawid

2017-11-01

There is a movement from generic quality checklists toward a more domain-based approach in critical appraisal tools. This study aimed to report on a first experience with the newly developed risk of bias in systematic reviews (ROBIS) tool and compare it with A Measurement Tool to Assess Systematic Reviews (AMSTAR), that is, the most common used tool to assess methodological quality of systematic reviews while assessing validity, reliability, and applicability. Validation study with four reviewers based on 16 systematic reviews in the field of occupational health. Interrater reliability (IRR) of all four raters was highest for domain 2 (Fleiss' kappa κ = 0.56) and lowest for domain 4 (κ = 0.04). For ROBIS, median IRR was κ = 0.52 (range 0.13-0.88) for the experienced pair of raters compared to κ = 0.32 (range 0.12-0.76) for the less experienced pair of raters. The percentage of "yes" scores of each review of ROBIS ratings was strongly correlated with the AMSTAR ratings (r s  = 0.76; P = 0.01). ROBIS has fair reliability and good construct validity to assess the risk of bias in systematic reviews. More validation studies are needed to investigate reliability and applicability, in particular. Copyright © 2017 Elsevier Inc. All rights reserved.

Good Looking Is Looking Good / Märt Milter

Index Scriptorium Estoniae

Milter, Märt

1998-01-01

Meloodilist drum ǹ̀bassi viljelevatest välismaa plaadifirmadest Good Looking Recordsist ja Looking Good Recordsist, mida juhib LTJ Bukem ja temaga koostööd tegevatest muusikutest Blame, Seba, Tayla, MC Conrad, Artemis

Bioenergy good practice

Energy Technology Data Exchange (ETDEWEB)

Birse, J.; Chambers, K.

2000-07-01

This report gives details of a project to make the Good Practice Guidelines, which were developed to help the UK Bioenergy industry, the national and local governments, and the public, more widely available. Details concerning the designing of a Good Practice Programme, and the proposed codes of Good Practice programme are given, and general relevant good practice guidance documents are discussed. The stakeholder survey and workshop, and the proposed codes of a Good Practice Programme are presented in Annexes. (UK)

Nudge for (the public) good

DEFF Research Database (Denmark)

Fosgaard, Toke Reinholt; Piovesan, Marco

In this paper we test the effect of non-binding defaults on the level of contribution to a public good. We manipulate the default numbers appearing on the decision screen to nudge subjects toward a free-rider strategy or a perfect conditional cooperator strategy. Our results show that the vast...

Nudge for (the public) good

DEFF Research Database (Denmark)

Fosgaard, Toke Reinholt; Piovesan, Marco

2015-01-01

In this paper we test the effect of non-binding defaults on the level of contribution to a public good. We manipulate the default numbers appearing on the decision screen to nudge subjects toward a free-rider strategy or a perfect conditional cooperator strategy. Our results show that the vast...

Altered specificity of single-chain antibody fragments bound to pandemic H1N1-2009 influenza virus after conversion of the phage-bound to the soluble form

Directory of Open Access Journals (Sweden)

Kaku Yoshihiro

2012-09-01

Full Text Available Abstract Background In 2009, a novel influenza A/H1N1 virus (H1N1pdm quickly spread worldwide and co-circulated with then-existing seasonal H1N1 virus (sH1N1. Distinguishing between these 2 viruses was necessary to better characterize the epidemiological properties of the emergent virus, including transmission patterns, pathogenesis, and anti-influenza drug resistance. This situation prompted us to develop a point-of-care virus differentiation system before entering the 2009–2010 influenza season. Aiming to establish H1N1pdm-specific detection tools rapidly, we employed phage display libraries to select H1N1pdm-specific single-chain variable fragments (scFvs. Findings Human single-fold scFv libraries (Tomlinson I + J underwent selection for the ability to bind H1N1pdm virus particles. Three rounds of panning brought 1152 phage-bound scFvs, of which 58 clones reacted with H1N1pdm specifically or preferentially over sH1N1 in an enzyme-linked immunosorbent assay (ELISA. After conversion of the scFvs to soluble form, 7 clones demonstrating high/stable expression were finally obtained. However, all the soluble scFvs except No. 29 were found to have lost their specificity/preference for H1N1pdm in ELISA. The specificity/preference of No. 29 was also confirmed by immunofluorescence assay and immunoprecipitation, and the viral nucleoprotein was identified by ELISA as its target protein. The change in specificity associated with scFv conversion from phage-bound to soluble form could be due to loss of phage scaffold pIII protein, which likely provides structural support for the scFv antigen-binding site. It is also possible that the similar antigenic properties of H1N1pdm and sH1N1 led to the observed alterations in scFv specificity. Discussion Using a phage display library, we obtained 7 soluble scFv clones reactive against H1N1pdm; however, only 1 showed specificity/preference toward H1N1pdm. Our results confirmed that using phage display

Buying stolen goods: the ambiguity in trading consumer-to-consumer

DEFF Research Database (Denmark)

Kammersgaard, Tobias; Heinskou, Marie Bruvik; Demant, Jakob

2017-01-01

This study investigates the buying of stolen goods in Denmark. The study consists of a self-report survey based on a representative sample of the general Danish population (n = 2311) and six focus group interviews consisting of both informants experienced with buying stolen goods and of those...... with no experience (n = 37). The survey showed that 4.8% had bought stolen goods, while 15.7% were uncertain whether they had bought stolen goods. Young people, males, and unemployed were more likely to purchase stolen goods. No clear correlation between income and buying stolen goods was found. Focus groups suggest...... the buyers of stolen goods did not buy stolen goods because they could not afford legitimate products. We recommend targeting consumers not interested in buying stolen goods with information about how to avoid such activity....

The role of forgetting in undermining good intentions.

Directory of Open Access Journals (Sweden)

Kristina R Olson

Full Text Available Evaluating others is a fundamental feature of human social interaction--we like those who help more than those who hinder. In the present research, we examined social evaluation of those who not only intentionally performed good and bad actions but also those to whom good things have happened (the lucky and those to whom bad things have happened (the unlucky. In Experiment 1a, subjects demonstrated a sympathetic preference for the unlucky. However, under cognitive load (Experiment 1b, no such preference was expressed. Further, in Experiments 2a and 2b, when a time delay between impression formation (learning and evaluation (memory test was introduced, results showed that younger (Experiment 2a and older adults (Experiment 2b showed a significant preference for the lucky. Together these experiments show that a consciously motivated sympathetic preference for those who are unlucky dissolves when memory is disrupted. The observed dissociation provides evidence for the presence of conscious good intentions (favoring the unlucky and the cognitive compromising of such intentions when memory fails.

Pedagogical Uses of the Public Goods Concept in Economics.

Science.gov (United States)

Kiesling, Herbert J.

1990-01-01

Describes some of the relatively unknown aspects of the concept of public goods and shows how they might be brought into undergraduate textbooks in microeconomic principles, public finance, and welfare economics. Illustrates how these aspects of public goods can be brought into undergraduate instruction. (DB)

Selection of diethylstilbestrol-specific single-chain antibodies from a non-immunized mouse ribosome display library.

Directory of Open Access Journals (Sweden)

Yanan Sun

Full Text Available Single chain variable fragments (scFvs against diethylstilbestrol (DES were selected from the splenocytes of non-immunized mice by ribosome display technology. A naive library was constructed and engineered to allow in vitro transcription and translation using an E. coli lysate system. Alternating selection in solution and immobilization in microtiter wells was used to pan mRNA-ribosome-antibody (ARM complexes. After seven rounds of ribosome display, the expression vector pTIG-TRX containing the selected specific scFv DNAs were transformed into Escherichia coli BL21 (DE3 for expression. Twenty-six positive clones were screened and five clones had high antibody affinity and specificity to DES as evidenced by indirect competitive ELISA. Sequence analysis showed that these five DES-specific scFvs had different amino acid sequences, but the CDRs were highly similar. Surface plasmon resonance (SPR analysis was used to determine binding kinetics of one clone (30-1. The measured K(D was 3.79 µM. These results indicate that ribosome display technology can be used to efficiently isolate hapten-specific antibody (Ab fragments from a naive library; this study provides a methodological framework for the development of novel immunoassays for multiple environmental pollutants with low molecular weight detection using recombinant antibodies.

Characterization of a single-chain variable fragment recognizing a linear epitope of aβ: a biotechnical tool for studies on Alzheimer's disease?

Directory of Open Access Journals (Sweden)

Silke Dornieden

Full Text Available Alzheimer's disease (AD is a progressive neurodegenerative disorder with devastating effects. Currently, therapeutic options are limited to symptomatic treatment. For more than a decade, research focused on immunotherapy for the causal treatment of AD. However, clinical trials with active immunization using Aβ encountered severe complications, for example meningoencephalitis. Consequently, attention focused on passive immunization using antibodies. As an alternative to large immunoglobulins (IgGs, Aβ binding single-chain variable fragments (scFvs were used for diagnostic and therapeutic research approaches. scFvs can be expressed in E. coli and may provide improved pharmacokinetic properties like increased blood-brain barrier permeability or reduced side-effects in vivo. In this study, we constructed an scFv from an Aβ binding IgG, designated IC16, which binds the N-terminal region of Aβ (Aβ(1-8. scFv-IC16 was expressed in E. coli, purified and characterized with respect to its interaction with different Aβ species and its influence on Aβ fibril formation. We were able to show that scFv-IC16 strongly influenced the aggregation behavior of Aβ and could be applied as an Aβ detection probe for plaque staining in the brains of transgenic AD model mice. The results indicate potential for therapy and diagnosis of AD.

Meet the good child

DEFF Research Database (Denmark)

Gram, Malene; Grønhøj, Alice

2016-01-01

This article explores ‘childing’ pratices in relation to family supermarket shopping in Denmark. ‘Parenting’ practices have been explored for long but little attention has been given to how children strive to be ‘good’ children, who live up to certain standards and recognize what they perceive...... to be appropriate child and parental behavior. The study takes a practice theoretical perspective, building on previous research on family consumption, and draws empirically on 35 interviews with 5–6 year-olds and 13 family interviews. Findings show that the children recognize the position of ‘the good child......’ and most often prefer to take on this position, which is confirmed by their parents. The children can describe how ‘the good child’—in their eyes—should behave. They prefer consensus and not being embarrassing or embarrassed. The study concludes that the children are strongly immersed in social norms...

Good and bad practices in pv plants

OpenAIRE

Martinez Moreno, Francisco; Helleputte, F.; Tyutyundzhiev, N.; Rabal Echeverria, Daniel; Conlon, Michael; Fartaria, Tomás; Oteiza, David

2013-01-01

The PVCROPS project (PhotoVolta ic Cost r€duction, Reliability, Operational performance, Prediction and Simulation), cofinanced by European Commission in the frame of Seventh Framework Programme, has compiled in the “Good and bad practices: Manual to improve the quality and reduce the cost of PV systems” a collection of good and bad practices in actual PV plants . All the situations it collects represent the state-of-the-art of existing PV installations all around Europe. They show how ...

Software licenses: Good fences make good neighbors

International Nuclear Information System (INIS)

McCreary, J.G.; Woodyard, A.

1995-01-01

The basis for a good contract is that it is beneficial to both parties. A good foundation will cement the responsibilities and obligations of the parties after areas of agreement have been negotiated. Unfortunately, software licenses do not always reflect what is best for all. Some clauses are definitely for the benefit of the vendor, while others are required by a prudent client. The resulting contract is then a matter of reasonable compromise to achieve a good business relationship. Major issues of warranty, liability, training, support, and payment may be in conflict. Such topics as maintenance, testing, patents, extent of use, and return of software are often overlooked or addressed unevenly. This paper addresses these subjects and provides guidelines for software licenses. An understanding of legal phrases is of value. A better understanding of the viewpoints of both the vendor and the client results in a better working relationship

Conceptual Models Core to Good Design

CERN Document Server

Johnson, Jeff

2011-01-01

People make use of software applications in their activities, applying them as tools in carrying out tasks. That this use should be good for people--easy, effective, efficient, and enjoyable--is a principal goal of design. In this book, we present the notion of Conceptual Models, and argue that Conceptual Models are core to achieving good design. From years of helping companies create software applications, we have come to believe that building applications without Conceptual Models is just asking for designs that will be confusing and difficult to learn, remember, and use. We show how Concept

Switch for Good Community Program

Energy Technology Data Exchange (ETDEWEB)

Crawford, Tabitha [Balfour Beatty Military Housing Management LLC, Newtown Square, PA (United States); Amran, Martha [WattzOn, Inc., Mountain View, CA (United States)

2013-11-19

Switch4Good is an energy-savings program that helps residents reduce consumption from behavior changes; it was co-developed by Balfour Beatty Military Housing Management (BB) and WattzOn in Phase I of this grant. The program was offered at 11 Navy bases. Three customer engagement strategies were evaluated, and it was found that Digital Nudges (a combination of monthly consumption statements with frequent messaging via text or email) was most cost-effective. The program was delivered on-time and on-budget, and its success is based on the teamwork of local BB staff and the WattzOn team. The following graphic shows Switch4Good “by the numbers”, e.g. the scale of operations achieved during Phase I.

Depreciation of public goods in spatial public goods games

Science.gov (United States)

Shi, Dong-Mei; Zhuang, Yong; Li, Yu-Jian; Wang, Bing-Hong

2011-10-01

In real situations, the value of public goods will be reduced or even lost because of external factors or for intrinsic reasons. In this work, we investigate the evolution of cooperation by considering the effect of depreciation of public goods in spatial public goods games on a square lattice. It is assumed that each individual gains full advantage if the number of the cooperators nc within a group centered on that individual equals or exceeds the critical mass (CM). Otherwise, there is depreciation of the public goods, which is realized by rescaling the multiplication factor r to (nc/CM)r. It is shown that the emergence of cooperation is remarkably promoted for CM > 1 even at small values of r, and a global cooperative level is achieved at an intermediate value of CM = 4 at a small r. We further study the effect of depreciation of public goods on different topologies of a regular lattice, and find that the system always reaches global cooperation at a moderate value of CM = G - 1 regardless of whether or not there exist overlapping triangle structures on the regular lattice, where G is the group size of the associated regular lattice.

International Good Market Segmentation and Financial Market Structure

OpenAIRE

Basak, Suleyman; Croitoru, Benjamin

2003-01-01

While financial markets have recently become more complete and international capital flows well liberalized, markets for goods remain segmented. To investigate how more complete security markets may relieve the effects of this segmentation, we examine a series of two-country economies with internationally segmented good markets, distinguished by the available financial securities. We show that, under heterogeneity within countries, the financial structure matters: even with internationally co...

Pigeons can discriminate "good" and "bad" paintings by children.

Science.gov (United States)

Watanabe, Shigeru

2010-01-01

Humans have the unique ability to create art, but non-human animals may be able to discriminate "good" art from "bad" art. In this study, I investigated whether pigeons could be trained to discriminate between paintings that had been judged by humans as either "bad" or "good". To do this, adult human observers first classified several children's paintings as either "good" (beautiful) or "bad" (ugly). Using operant conditioning procedures, pigeons were then reinforced for pecking at "good" paintings. After the pigeons learned the discrimination task, they were presented with novel pictures of both "good" and "bad" children's paintings to test whether they had successfully learned to discriminate between these two stimulus categories. The results showed that pigeons could discriminate novel "good" and "bad" paintings. Then, to determine which cues the subjects used for the discrimination, I conducted tests of the stimuli when the paintings were of reduced size or grayscale. In addition, I tested their ability to discriminate when the painting stimuli were mosaic and partial occluded. The pigeons maintained discrimination performance when the paintings were reduced in size. However, discrimination performance decreased when stimuli were presented as grayscale images or when a mosaic effect was applied to the original stimuli in order to disrupt spatial frequency. Thus, the pigeons used both color and pattern cues for their discrimination. The partial occlusion did not disrupt the discriminative behavior suggesting that the pigeons did not attend to particular parts, namely upper, lower, left or right half, of the paintings. These results suggest that the pigeons are capable of learning the concept of a stimulus class that humans name "good" pictures. The second experiment showed that pigeons learned to discriminate watercolor paintings from pastel paintings. The subjects showed generalization to novel paintings. Then, as the first experiment, size reduction test

Virtual goods recommendations in virtual worlds.

Science.gov (United States)

Chen, Kuan-Yu; Liao, Hsiu-Yu; Chen, Jyun-Hung; Liu, Duen-Ren

2015-01-01

Virtual worlds (VWs) are computer-simulated environments which allow users to create their own virtual character as an avatar. With the rapidly growing user volume in VWs, platform providers launch virtual goods in haste and stampede users to increase sales revenue. However, the rapidity of development incurs virtual unrelated items which will be difficult to remarket. It not only wastes virtual global companies' intelligence resources, but also makes it difficult for users to find suitable virtual goods fit for their virtual home in daily virtual life. In the VWs, users decorate their houses, visit others' homes, create families, host parties, and so forth. Users establish their social life circles through these activities. This research proposes a novel virtual goods recommendation method based on these social interactions. The contact strength and contact influence result from interactions with social neighbors and influence users' buying intention. Our research highlights the importance of social interactions in virtual goods recommendation. The experiment's data were retrieved from an online VW platform, and the results show that the proposed method, considering social interactions and social life circle, has better performance than existing recommendation methods.

Different goods, different effects: Exploring the roles of generalized trust in public goods provision

DEFF Research Database (Denmark)

Sønderskov, Kim

-product situation (whether to buy organic food or not). This design provides a possibility to detect whether any effect of generalized trust is due to strategic behavior or due to altruistic motives among trusters. The results show that generalized trust enhances recycling significantly whereas it only has a very......This paper tests the hypothesis that generalized trust helps solve large-n collective action problems in a rationalistic framework. A rigors test is employed in that the hypothesis is tested in two different choice situations; a pure public good situation (whether to recycle or not) and a joint...... week positive effect on organic food consumption. Hence, generalized trust only affects public good provision when a collective action problem is present. The analyses thus sustain the hypothesis. It is furthermore concluded that the effect of generalized trust is due to strategic behavior...

Good government and good governance: record keeping in a ...

African Journals Online (AJOL)

This article addresses the challenges that arise when record keeping systems are advocated as a necessary under-pinning for good government and good governance. The relationship between record keeping and accountability is analysed and contextualised in relation to transparency and Freedom of Information ...

Good Enough to Teach?

DEFF Research Database (Denmark)

Denver, Louise; Jensen, Christian; Mees, Inger

2016-01-01

to improve their communicative effectiveness. The feedback was given by experienced tutors of English who had extensive experience of teaching and assessing English in an everyday ELF context. This paper sets out to investigate what sort of recommendations were provided, concentrating on the 24 lecturers...... whose L1 was Danish. An examination of the tutors’ comments showed that they could be divided into two main categories: formal language skills and pragmatic or metadiscursive features. The observations on language features are presented using a slightly adapted version of Lavelle’s (2008) “good......; Jenkins et al. 2011: 301), the analyses of the tutors’ comments to the 24 lecturers in the present study show that both aspects should be attributed importance....

Depreciation of public goods in spatial public goods games

International Nuclear Information System (INIS)

Shi, Dong-Mei; Zhuang, Yong; Li, Yu-Jian; Wang, Bing-Hong

2011-01-01

In real situations, the value of public goods will be reduced or even lost because of external factors or for intrinsic reasons. In this work, we investigate the evolution of cooperation by considering the effect of depreciation of public goods in spatial public goods games on a square lattice. It is assumed that each individual gains full advantage if the number of the cooperators n c within a group centered on that individual equals or exceeds the critical mass (CM). Otherwise, there is depreciation of the public goods, which is realized by rescaling the multiplication factor r to (n c /CM)r. It is shown that the emergence of cooperation is remarkably promoted for CM > 1 even at small values of r, and a global cooperative level is achieved at an intermediate value of CM = 4 at a small r. We further study the effect of depreciation of public goods on different topologies of a regular lattice, and find that the system always reaches global cooperation at a moderate value of CM = G − 1 regardless of whether or not there exist overlapping triangle structures on the regular lattice, where G is the group size of the associated regular lattice

"Good mothering" or "good citizenship"?

Science.gov (United States)

Porter, Maree; Kerridge, Ian H; Jordens, Christopher F C

2012-03-01

Umbilical cord blood banking is one of many biomedical innovations that confront pregnant women with new choices about what they should do to secure their own and their child's best interests. Many mothers can now choose to donate their baby's umbilical cord blood (UCB) to a public cord blood bank or pay to store it in a private cord blood bank. Donation to a public bank is widely regarded as an altruistic act of civic responsibility. Paying to store UCB may be regarded as a "unique opportunity" to provide "insurance" for the child's future. This paper reports findings from a survey of Australian women that investigated the decision to either donate or store UCB. We conclude that mothers are faced with competing discourses that force them to choose between being a "good mother" and fulfilling their role as a "good citizen." We discuss this finding with reference to the concept of value pluralism.

Efficient refolding and immobilization of PMMA-tag-fused single-chain Fv antibodies for sensitive immunological detection on a PMMA plate.

Science.gov (United States)

Kumada, Yoichi; Ishikawa, Yasuyuki; Fujiwara, Yusuke; Takeda, Rui; Miyamoto, Ryosuke; Niwa, Daisuke; Momose, Shun; Kang, Bongmun; Kishimoto, Michimasa

2014-09-01

In this study, we investigated the efficient refolding and site-specific immobilization of single-chain variable fragments (scFvs) genetically fused with a poly(methylmethacrylate)-binding peptide (PMMA-tag). According to the results of an aggregation test of a scFv-PM in the presence of 0.5 M urea, aggregation was hardly detectable at a weak-alkaline pH (8.5) with lower concentrations of NaCl. Consequently, more than 93% recovery of the anti-RNase scFv-PM model was attained, when it was refolded by dialysis against 50 mM TAPS (pH8.5). These results suggested that the apparent isoelectric point (pI) of a target scFv was decreased to a great extent by the genetic fusion of a PMMA-tag containing 5 acidic amino acids, and, thus, the solubility of the scFv-PM in its semi-denatured form was considerably improved. We also designed alternative peptide-tags composed of plural aspartic acid residues (D5, D10 and D15-tags) to decrease the apparent pI value of the fusion protein. As a consequence, scFv-D5, scFv-D10 and scFv-D15 were also efficiently refolded with yields of more than 95%. It is noteworthy that even scFv-PS-D15, which had both a positively charged polystyrene-binding peptide (PS-tag) and a negatively charged D15-tag, was serially connected at the C-terminal region of scFvs, and also refolded with a yield of 96.1%. These results clearly indicate that controlling the apparent pI value of scFvs by the fusion of oligo-peptides composed of acidic amino acids at the C-terminus resulted in a high degree of recovery via dialysis refolding. According to the results of a sandwich ELISA using scFv-PMs, scFv-D15 and scFv-PS-D15 as ligands, high antigen-binding signals were detected from both the PMMA and phi-PS plates immobilized with scFv-PMs. Furthermore, the high antigen-binding activity of scFv-PMs was maintained in an adsorption state when it was immobilized on the surface of not only PMMA, but also hydrophilic PS (phi-PS) and polycarbonate (PC). These results

Land use, worker heterogeneity and welfare benefits of public goods

NARCIS (Netherlands)

Teulings, Coen N.; Ossokina, Ioulia V.; de Groot, Henri L.F.

2018-01-01

We show that investments in public goods change the optimal land use in their vicinity, leading to additional welfare benefits. This occurs through two sorting mechanisms. First, availability of public goods leads to higher population densities. Second, population groups sort according to their

Cooperation and the common good.

Science.gov (United States)

Johnstone, Rufus A; Rodrigues, António M M

2016-02-05

In this paper, we draw the attention of biologists to a result from the economic literature, which suggests that when individuals are engaged in a communal activity of benefit to all, selection may favour cooperative sharing of resources even among non-relatives. Provided that group members all invest some resources in the public good, they should refrain from conflict over the division of these resources. The reason is that, given diminishing returns on investment in public and private goods, claiming (or ceding) a greater share of total resources only leads to the actor (or its competitors) investing more in the public good, such that the marginal costs and benefits of investment remain in balance. This cancels out any individual benefits of resource competition. We illustrate how this idea may be applied in the context of biparental care, using a sequential game in which parents first compete with one another over resources, and then choose how to allocate the resources they each obtain to care of their joint young (public good) versus their own survival and future reproductive success (private good). We show that when the two parents both invest in care to some extent, they should refrain from any conflict over the division of resources. The same effect can also support asymmetric outcomes in which one parent competes for resources and invests in care, whereas the other does not invest but refrains from competition. The fact that the caring parent gains higher fitness pay-offs at these equilibria suggests that abandoning a partner is not always to the latter's detriment, when the potential for resource competition is taken into account, but may instead be of benefit to the 'abandoned' mate. © 2016 The Author(s).

Irradiation of goods

International Nuclear Information System (INIS)

Lunt, R.E.

1987-01-01

Mechanical handling apparatus is adapted to handle goods, such as boxed fruit, during a process of irradiation, in palletized form. Palletized goods are loaded onto wheeled vehicles in a loading zone. Four vehicles are wheeled on a track into an irradiation zone via a door in a concrete shield. The vehicles are arranged in orthogonal relationship around a source of square section. Turntables are positioned at corners of the square shaped rail truck around the source selectively to turn the vehicles to align then with track sections. Mechanical manipulating devices are positioned in the track sections opposed to sides of the source. During irradiation, the vehicles and their palletized goods are cylically moved toward the source to offer first sides of the goods for irradiation and are retraced from the source and are pivoted through 90 0 to persent succeeding sides of the goods for irradiation

Optimalisasi Penerapan Prinsip Good Governance Bidang Akademik dalam Upaya Mewujudkan Good University Governance

Directory of Open Access Journals (Sweden)

Hery Harjono Muljo

2014-05-01

Full Text Available This study wants to know and understand whether good governance principles have been well applied as well as the factors influencing optimization of the implementation of good governance principles on the academic field in an effort to realize good university governance in Bina Nusantara University. The study aims to evaluate the implementation of good governance principles on the academic field, know the factors that affect the implementation of good governance principles on the academic field, and improve and develop the academic areas in accordance with good governance principles in order to maximize the role of Bina Nusantara University as Good University Governance. The approach model used to understand the implementation of good governance principles was a model to educational institution using the 8 principles, namely academic freedom, shared governance, clear rights and responsibilities, selection at merit, financial stability, accountability, regular testing of standards, and the importance of close cooperation. Research used qualitative method with descriptive analysis, by analyzing the factors influencing optimization of the implementation of good governance principles, particularly on academic areas. The results achieved there were 18 factors that affect the optimization of the implementation of good governance principles. Then the factors affected the optimization ofthe implementation of good governance principles the most are operational centralization and academic decentralization which were the novelty of this study.

Public goods games on adaptive coevolutionary networks

Science.gov (United States)

Pichler, Elgar; Shapiro, Avi M.

2017-07-01

Productive societies feature high levels of cooperation and strong connections between individuals. Public Goods Games (PGGs) are frequently used to study the development of social connections and cooperative behavior in model societies. In such games, contributions to the public good are made only by cooperators, while all players, including defectors, reap public goods benefits, which are shares of the contributions amplified by a synergy factor. Classic results of game theory show that mutual defection, as opposed to cooperation, is the Nash Equilibrium of PGGs in well-mixed populations, where each player interacts with all others. In this paper, we explore the coevolutionary dynamics of a low information public goods game on a complex network in which players adapt to their environment in order to increase individual payoffs relative to past payoffs parameterized by greediness. Players adapt by changing their strategies, either to cooperate or to defect, and by altering their social connections. We find that even if players do not know other players' strategies and connectivity, cooperation can arise and persist despite large short-term fluctuations.

Piling up technology of goods irradiated by single plate source

International Nuclear Information System (INIS)

Xia Hezhou; Chen Yuxia; Cao Hongyun; Lin Yong; Zhou guoquan

1999-01-01

In the irradiation process of piling up goods in static state, four irradiation working sites and single plate source was adopted. The results showed that piling up in this way remarkably raised the irradiation quality of goods. The utilization rate of radioactive ray reached 22.27%

Generation of “LYmph Node Derived Antibody Libraries” (LYNDAL) for selecting fully human antibody fragments with therapeutic potential.

Science.gov (United States)

Diebolder, Philipp; Keller, Armin; Haase, Stephanie; Schlegelmilch, Anne; Kiefer, Jonathan D; Karimi, Tamana; Weber, Tobias; Moldenhauer, Gerhard; Kehm, Roland; Eis-Hübinger, Anna M; Jäger, Dirk; Federspil, Philippe A; Herold-Mende, Christel; Dyckhoff, Gerhard; Kontermann, Roland E; Arndt, Michaela A E; Krauss, Jürgen

2014-01-01

The development of efficient strategies for generating fully human monoclonal antibodies with unique functional properties that are exploitable for tailored therapeutic interventions remains a major challenge in the antibody technology field. Here, we present a methodology for recovering such antibodies from antigen-encountered human B cell repertoires. As the source for variable antibody genes, we cloned immunoglobulin G (IgG)-derived B cell repertoires from lymph nodes of 20 individuals undergoing surgery for head and neck cancer. Sequence analysis of unselected “LYmph Node Derived Antibody Libraries” (LYNDAL) revealed a naturally occurring distribution pattern of rearranged antibody sequences, representing all known variable gene families and most functional germline sequences. To demonstrate the feasibility for selecting antibodies with therapeutic potential from these repertoires, seven LYNDAL from donors with high serum titers against herpes simplex virus (HSV) were panned on recombinant glycoprotein B of HSV-1. Screening for specific binders delivered 34 single-chain variable fragments (scFvs) with unique sequences. Sequence analysis revealed extensive somatic hypermutation of enriched clones as a result of affinity maturation. Binding of scFvs to common glycoprotein B variants from HSV-1 and HSV-2 strains was highly specific, and the majority of analyzed antibody fragments bound to the target antigen with nanomolar affinity. From eight scFvs with HSV-neutralizing capacity in vitro,the most potent antibody neutralized 50% HSV-2 at 4.5 nM as a dimeric (scFv)2. We anticipate our approach to be useful for recovering fully human antibodies with therapeutic potential.

Toxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes

Energy Technology Data Exchange (ETDEWEB)

Nadanaciva, Sashi [Compound Safety Prediction, Worldwide Medicinal Chemistry, Pfizer, Inc., Groton, CT 06340 (United States); Aleo, Michael D. [Drug Safety Research and Development, Pfizer Inc., Groton, CT 06340 (United States); Strock, Christopher J. [Cyprotex US, Watertown, MA 02472 (United States); Stedman, Donald B. [Drug Safety Research and Development, Pfizer Inc., Groton, CT 06340 (United States); Wang, Huijun [Computational Sciences, Pfizer Inc., Groton, CT 06340 (United States); Will, Yvonne, E-mail: yvonne.will@pfizer.com [Compound Safety Prediction, Worldwide Medicinal Chemistry, Pfizer, Inc., Groton, CT 06340 (United States)

2013-10-15

To reduce costly late-stage compound attrition, there has been an increased focus on assessing compounds in in vitro assays that predict attributes of human safety liabilities, before preclinical in vivo studies are done. Relevant questions when choosing a panel of assays for predicting toxicity are (a) whether there is general concordance in the data among the assays, and (b) whether, in a retrospective analysis, the rank order of toxicity of compounds in the assays correlates with the known safety profile of the drugs in humans. The aim of our study was to answer these questions using nonsteroidal anti-inflammatory drugs (NSAIDs) as a test set since NSAIDs are generally associated with gastrointestinal injury, hepatotoxicity, and/or cardiovascular risk, with mitochondrial impairment and endoplasmic reticulum stress being possible contributing factors. Eleven NSAIDs, flufenamic acid, tolfenamic acid, mefenamic acid, diclofenac, meloxicam, sudoxicam, piroxicam, diflunisal, acetylsalicylic acid, nimesulide, and sulindac (and its two metabolites, sulindac sulfide and sulindac sulfone), were tested for their effects on (a) the respiration of rat liver mitochondria, (b) a panel of mechanistic endpoints in rat hepatocytes, and (c) the viability and organ morphology of zebrafish. We show good concordance for distinguishing among/between NSAID chemical classes in the observations among the three approaches. Furthermore, the assays were complementary and able to correctly identify “toxic” and “non-toxic” drugs in accordance with their human safety profile, with emphasis on hepatic and gastrointestinal safety. We recommend implementing our multi-assay approach in the drug discovery process to reduce compound attrition. - Highlights: • NSAIDS cause liver and GI toxicity. • Mitochondrial uncoupling contributes to NSAID liver toxicity. • ER stress is a mechanism that contributes to liver toxicity. • Zebrafish and cell based assays are complimentary.

Toxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes

International Nuclear Information System (INIS)

Nadanaciva, Sashi; Aleo, Michael D.; Strock, Christopher J.; Stedman, Donald B.; Wang, Huijun; Will, Yvonne

2013-01-01

To reduce costly late-stage compound attrition, there has been an increased focus on assessing compounds in in vitro assays that predict attributes of human safety liabilities, before preclinical in vivo studies are done. Relevant questions when choosing a panel of assays for predicting toxicity are (a) whether there is general concordance in the data among the assays, and (b) whether, in a retrospective analysis, the rank order of toxicity of compounds in the assays correlates with the known safety profile of the drugs in humans. The aim of our study was to answer these questions using nonsteroidal anti-inflammatory drugs (NSAIDs) as a test set since NSAIDs are generally associated with gastrointestinal injury, hepatotoxicity, and/or cardiovascular risk, with mitochondrial impairment and endoplasmic reticulum stress being possible contributing factors. Eleven NSAIDs, flufenamic acid, tolfenamic acid, mefenamic acid, diclofenac, meloxicam, sudoxicam, piroxicam, diflunisal, acetylsalicylic acid, nimesulide, and sulindac (and its two metabolites, sulindac sulfide and sulindac sulfone), were tested for their effects on (a) the respiration of rat liver mitochondria, (b) a panel of mechanistic endpoints in rat hepatocytes, and (c) the viability and organ morphology of zebrafish. We show good concordance for distinguishing among/between NSAID chemical classes in the observations among the three approaches. Furthermore, the assays were complementary and able to correctly identify “toxic” and “non-toxic” drugs in accordance with their human safety profile, with emphasis on hepatic and gastrointestinal safety. We recommend implementing our multi-assay approach in the drug discovery process to reduce compound attrition. - Highlights: • NSAIDS cause liver and GI toxicity. • Mitochondrial uncoupling contributes to NSAID liver toxicity. • ER stress is a mechanism that contributes to liver toxicity. • Zebrafish and cell based assays are complimentary

The common good

OpenAIRE

Argandoña, Antonio

2011-01-01

The concept of the common good occupied a relevant place in classical social, political and economic philosophy. After losing ground in the Modern age, it has recently reappeared, although with different and sometimes confusing meanings. This paper is the draft of a chapter of a Handbook; it explains the meaning of common good in the Aristotelian-Thomistic philosophy and in the Social Doctrine of the Catholic Church; why the common good is relevant; and how it is different from the other uses...

A Good Teaching Technique: WebQuests

Science.gov (United States)

Halat, Erdogan

2008-01-01

In this article, the author first introduces and describes a new teaching tool called WebQuests to practicing teachers. He then provides detailed information about the structure of a good WebQuest. Third, the author shows the strengths and weaknesses of using Web-Quests in teaching and learning. Last, he points out the challenges for practicing…

Trade in goods

DEFF Research Database (Denmark)

Sørensen, Karsten Engsig

2006-01-01

An analysis of the rules governing trade in goods under the GATT agreement and the Agreement on Safeguards......An analysis of the rules governing trade in goods under the GATT agreement and the Agreement on Safeguards...

Echoic memory processes in good and poor readers.

Science.gov (United States)

Sipe, S; Engle, R W

1986-07-01

Four experiments were conducted to determine whether echoic memory plays a role in differences between good and poor readers. The first two experiments used a suffix procedure in which the subject is read a list of digits with either a tone control or the word go appended to the list. For lists that exceeded the length of the subjects memory span by one digit (i.e., that avoided ceiling effects), the poor readers showed a larger decrement in the suffix condition than did the good readers. The third experiment was directed at the question of whether the duration of echoic memory is different for good and poor readers. Children shadowed words presented to one ear at a rate determined to give 75-85% shadowing accuracy. The items presented to the nonattended ear were words and an occasional digit. At various intervals after the presentation of the digit, a light signaled that the subject was to cease shadowing and attempt to recall any digit that had occurred in the nonattended ear recently. Whereas good and poor readers recalled the digit equally if tested immediately after presentation, the poor readers showed a faster decline in recall of the digit as retention interval increased. A fourth experiment was conducted to determine whether the differences in echoic memory were specific to speech stimuli or occurred at a more basic level of aural persistence. Bursts of white noise were separated by 9-400 ms of silence and the subject was to say whether there were one or two sounds presented. There were no differences in detectability functions for good and poor readers.

Return on research investments: personal good versus public good

Science.gov (United States)

Fox, P. A.

2017-12-01

For some time the outputs, i.e. what's produced, of publicly and privately funded research while necessary, are far from sufficient, when considering an overall return on (research) investment. At the present time products such as peer-reviewed papers, websites, data, and software are recognized by funders on timescales related to research awards and reporting. However, from a consumer perspective impact and value are determined at the time a product is discovered, accessed, assessed and used. As is often the case, the perspectives of producer and consumer communities can be distinct and not intersect at all. We contrast personal good, i.e. credit, reputation, with that of public good, e.g. interest, leverage, exploitation, and more. This presentation will elaborate on both the metaphorical and idealogical aspects of applying a "return on investment" frame for the topic of assessing "good".

Cape Verde: Marketing Good Governance Kap Verde: Die Vermarktung von Good Governance

Directory of Open Access Journals (Sweden)

Bruce Baker

2009-01-01

Full Text Available Faced with a lack of natural resources Cape Verde has made good governance one of its most marketable products. Running parallel to the institutionalisation of democratic politics there has been an overhaul and growing sophistication in public administration, though certain weaknesses persist. This report argues that it is reform and improvement in this area in particular that has enabled this small island state to punch above its weight and achieve remarkable social, economic and political results. But will the successful formula of the past decade prove sufficient for the future? Poverty and unemployment have by no means been conquered. Much of the economic growth has been based in the tourist sector and the government is well aware of the dangers of over-reliance on a single industry. Cape Verde’s midway location between South America and Europe and its increasing international transport connections will continue to offer advantages to drug traffickers. The next few years of the world financial crisis will show whether marketing good governance is enough and whether this is the model for small resource developing states. Der Inselstaat Kap Verde hat seine Anstrengungen zu guter Regierungsführung (Good Governance erfolgreich demonstriert. Parallel zur Institutionalisierung demokratischer Regierungsstrukturen wurde die Verwaltung reformiert und modernisiert, wenn auch immer noch Problembereiche erkennbar sind. Der Autor sieht insbesondere in den politischen und administrativen Reformen den Hintergrund für die erfolgreiche soziale, wirtschaftliche und politische Entwicklung dieser kleinen Inselrepublik. Aber wird dieses Rezept, das im vergangenen Jahrzehnt seine Wirksamkeit beweisen konnte, auch in Zukunft ausreichend sein? Armut und Unterbeschäftigung sind keineswegs besiegt. Ein Großteil des Wirtschaftswachstums basiert auf dem Tourismussektor; die Regierung ist sich der Gefahr wohl bewusst, die in zu großer Abhängigkeit von einem

Re-engineering of the PAM1 phage display monoclonal antibody to produce a soluble, versatile anti-homogalacturonan scFv

DEFF Research Database (Denmark)

Manfield, I. W.; Bernal Giraldo, Adriana Jimena; Møller, I.

2006-01-01

Antibody phage display is an increasingly important alternative method for the production of monoclonal antibodies (mAbs) and involves the expression of antibody fragments (scFvs) at the surface of bacteriophage particles. We have previously used this technique to generate a phage mAb (PAM1phage...

Transport of hazardous goods

International Nuclear Information System (INIS)

1989-01-01

The course 'Transport of hazardous goods' was held in Berlin in November 1988 in cooperation with the Bundesanstalt fuer Materialforschung und -pruefung. From all lecturs, two are recorded separately: 'Safety of tank trucks - requirements on the tank, development possibiities of active and passive safety' and 'Requirements on the transport of radioactive materials - possible derivations for other hazardous goods'. The other lectures deal with hazardous goods law, requirements on packinging, risk assessment, railroad transport, hazardous goods road network, insurance matters, EC regulations, and waste tourism. (HSCH) [de

Assessing the sense of `good at' and `not good at' toward learning topics of mathematics with conjoint analysis

Science.gov (United States)

Izuta, Giido; Nishikawa, Tomoko

2017-05-01

Over the past years, educational psychology and pedagogy communities have focused on the metacognition formalism as a helpful approach to carry out investigations on the feeling of difficulty in mastering some classroom materials that students acquire through their subjective experiences of learning in schools. Motivated by hitherto studies, this work deals with the assessment of the awareness of `good at' and `not good at' that Japanese junior high school students have towards the main learning modules in their three years of mathematics. More specifically, the aims here are (i) to shed some light into how the awareness varies across the grades and gender; (ii) to get some insights into the extent to what the conjoint analysis can be applied to understand the students' feelings toward learning activities. To accomplish them, a conjoint analysis survey with three conjoint attributes, each with two levels, were designed to assess the learners' perceptions of `good at' and `not good at' with respect to arithmetic (algebraic operations), geometry and functions, which make up the three major modules of their curricula. The measurements took place in a public junior high school with 616 school children. It turned out that the conjoint analyses for boys and girls of each grade generated the partial utility and importance graphs which along with a pre-established precision of measurement allowed us to form groups of pupils according to their `sense of being good at' characteristics. Moreover, the results showed that the number of groups obtained differed for boys and girls as well as grades when the gender and school years were considered for comparisons. These findings suggesting that female students outnumbers their peers in number of `good at' despite the low number of females pursuing careers in mathematics and related fields imply that investigation on the causes of this juxtaposition has to be taken into account in the future.

A good patient?

DEFF Research Database (Denmark)

Campbell, Catherine; Scott, Kerry; Skovdal, Morten

2015-01-01

, physical cleanliness, honesty, gratitude and lifestyle adaptations (taking pills correctly andcoming to the clinic when told). As healthcare workers may decide to punish patients who do not live up the‘good patient persona’, many patients seek to perform within the confines of the ‘good patient persona...

On good ETOL forms

DEFF Research Database (Denmark)

Skyum, Sven

1978-01-01

This paper continues the study of ETOL forms and good EOL forms done by Maurer, Salomaa and Wood. It is proven that binary very complete ETOL forms exist, good synchronized ETOL forms exist and that no propagating or synchronized ETOL form can be very complete.......This paper continues the study of ETOL forms and good EOL forms done by Maurer, Salomaa and Wood. It is proven that binary very complete ETOL forms exist, good synchronized ETOL forms exist and that no propagating or synchronized ETOL form can be very complete....

On Having a Good

OpenAIRE

Korsgaard, Christine M.

2014-01-01

In some recent papers I have been arguing that the concept ‘good-for’ is prior to the concept of ‘good’ (in the sense in which final ends are good), and exploring the implications of that claim. One of those implications is that everything that is good is good for someone. That implication seems to fall afoul of our intuitions about certain cases, such as the intuition that a world full of happy people and animals is better than a world full of miserable ones, even if the people and animals a...

Accidental goodness?

DEFF Research Database (Denmark)

Richter, Anne

In postmodern capitalist market economies, management of the single organisation is bound to be guided by several rationales, which are in conflict with each other. For some writers this perception leads to the argument, that conceptions of management should strive towards goals beyond the present...... society. For others, the handling of plural perspectives is just a management discipline. However these positions seem to share a focus on organization as a the arena for the organization of the good. The contribution looks at the management of occupational accidents as an example of striving for good...

On the density of nearly regular graphs with a good edge-labelling

OpenAIRE

Mehrabian, Abbas

2011-01-01

A good edge-labelling of a simple graph is a labelling of its edges with real numbers such that, for any ordered pair of vertices (u,v), there is at most one nondecreasing path from u to v. Say a graph is good if it admits a good edge-labelling, and is bad otherwise. Our main result is that any good n-vertex graph whose maximum degree is within a constant factor of its average degree (in particular, any good regular graph) has at most n^{1+o(1)} edges. As a corollary, we show that there are b...

Private Financing of Public Goods by Means of 'Eco-Goods' Schemes

DEFF Research Database (Denmark)

Ueda, Yoshifumi; Wegener, Andreas; Svendsen, Gert Tinggaard

2010-01-01

With a view to applying to the problem of collective action for the global commons, we analyze a three-stage game model where public goods are provided by the costly leadership of a social entrepreneur for undertaking 'eco-goods' scheme. We derive (i) the conclusion that the social entrepreneur can...... finance more for the collective action under not-for-profit constraint than without the constraint, and (ii) the conditions under which he prefers the not-for-profit constraint on a rational basis. The main results are applied to some social experiments on the natural common-pools of a public-goods nature...

The Varieties of Good Design

DEFF Research Database (Denmark)

Ylirisku, Salu; Arvola, Mattias

2018-01-01

This chapter explores the philosopher and logician Georg Henrik von Wright’s metaethical treatise of the varieties of goodness in the context of design. von Wright investigated the use of notion of ‘good’ in language, and he identified six kinds of goodness: namely utilitarian goodness, instrumen......This chapter explores the philosopher and logician Georg Henrik von Wright’s metaethical treatise of the varieties of goodness in the context of design. von Wright investigated the use of notion of ‘good’ in language, and he identified six kinds of goodness: namely utilitarian goodness...

Design and Application of Automatic Falling Device for Different Brands of Goods

Science.gov (United States)

Yang, Xudong; Ge, Qingkuan; Zuo, Ping; Peng, Tao; Dong, Weifu

2017-12-01

The Goods-Falling device is an important device in the intelligent sorting goods sorting system, which is responsible for the temporary storage and counting of the goods, and the function of putting the goods on the conveyor belt according to certain precision requirements. According to the present situation analysis and actual demand of the domestic goods sorting equipment, a vertical type Goods - Falling Device is designed and the simulation model of the device is established. The dynamic characteristics such as the angular error of the opening and closing mechanism are carried out by ADAMS software. The simulation results show that the maximum angular error is 0.016rad. Through the test of the device, the goods falling speed is 7031/hour, the good of the falling position error within 2mm, meet the crawl accuracy requirements of the palletizing robot.

Dynamic pricing of network goods with boundedly rational consumers.

Science.gov (United States)

Radner, Roy; Radunskaya, Ami; Sundararajan, Arun

2014-01-07

We present a model of dynamic monopoly pricing for a good that displays network effects. In contrast with the standard notion of a rational-expectations equilibrium, we model consumers as boundedly rational and unable either to pay immediate attention to each price change or to make accurate forecasts of the adoption of the network good. Our analysis shows that the seller's optimal price trajectory has the following structure: The price is low when the user base is below a target level, is high when the user base is above the target, and is set to keep the user base stationary once the target level has been attained. We show that this pricing policy is robust to a number of extensions, which include the product's user base evolving over time and consumers basing their choices on a mixture of a myopic and a "stubborn" expectation of adoption. Our results differ significantly from those that would be predicted by a model based on rational-expectations equilibrium and are more consistent with the pricing of network goods observed in practice.

The Good Work.

Science.gov (United States)

Csikszentmihalyi, Mihaly

2003-01-01

Examines the working lives of geneticists and journalists to place into perspective what lies behind personal ethics and success. Defines "good work" as productive activity that is valued socially and loved by people engaged in it. Asserts that certain cultural values, social controls, and personal standards are necessary to maintain good work and…

A simple vector system to improve performance and utilisation of recombinant antibodies

Directory of Open Access Journals (Sweden)

Vincent Karen J

2006-12-01

Full Text Available Abstract Background Isolation of recombinant antibody fragments from antibody libraries is well established using technologies such as phage display. Phage display vectors are ideal for efficient display of antibody fragments on the surface of bacteriophage particles. However, they are often inefficient for expression of soluble antibody fragments, and sub-cloning of selected antibody populations into dedicated soluble antibody fragment expression vectors can enhance expression. Results We have developed a simple vector system for expression, dimerisation and detection of recombinant antibody fragments in the form of single chain Fvs (scFvs. Expression is driven by the T7 RNA polymerase promoter in conjunction with the inducible lysogen strain BL21 (DE3. The system is compatible with a simple auto-induction culture system for scFv production. As an alternative to periplasmic expression, expression directly in the cytoplasm of a mutant strain with a more oxidising cytoplasmic environment (Origami 2™ (DE3 was investigated and found to be inferior to periplasmic expression in BL21 (DE3 cells. The effect on yield and binding activity of fusing scFvs to the N terminus of maltose binding protein (a solubility enhancing partner, bacterial alkaline phosphatase (a naturally dimeric enzymatic reporter molecule, or the addition of a free C-terminal cysteine was determined. Fusion of scFvs to the N-terminus of maltose binding protein increased scFv yield but binding activity of the scFv was compromised. In contrast, fusion to the N-terminus of bacterial alkaline phosphatase led to an improved performance. Alkaline phosphatase provides a convenient tag allowing direct enzymatic detection of scFv fusions within crude extracts without the need for secondary reagents. Alkaline phosphatase also drives dimerisation of the scFv leading to an improvement in performance compared to monovalent constructs. This is illustrated by ELISA, western blot and

Human antibody fragments specific for Bothrops jararacussu venom reduce the toxicity of other Bothrops sp. venoms.

Science.gov (United States)

Roncolato, Eduardo Crosara; Pucca, Manuela Berto; Funayama, Jaqueline Carlos; Bertolini, Thaís Barboza; Campos, Lucas Benício; Barbosa, José Elpidio

2013-01-01

Approximately 20,000 snakebites are registered each year in Brazil. The classical treatment for venomous snakebite involves the administration of sera obtained from immunized horses. Moreover, the production and care of horses is costly, and the use of heterologous sera can cause hypersensitivity reactions. The production of human antibody fragments by phage display technology is seen as a means of overcoming some of these disadvantages. The studies here attempted to test human monoclonal antibodies specific to Bothrops jararacussu against other Bothrops sp. venoms, using the Griffin.1 library of human single-chain fragment-variable (scFv) phage antibodies. Using the Griffin.1 phage antibody library, this laboratory previously produced scFvs capable of inhibiting the phospholipase and myotoxic activities of Bothrops jararacussu venom. The structural and functional similarities of the various forms of phospholipase A2 (PLA₂) in Bothrops venom served as the basis for the present study wherein the effectiveness of those same scFvs were evaluated against B. jararaca, B. neuwiedi, and B. moojeni venoms. Each clone was found to recognize all three Bothrops venoms, and purified scFvs partially inhibited their in vitro phospholipase activity. In vivo assays demonstrated that the scFv clone P2B7 reduced myotoxicity and increased the survival of animals that received the test venoms. The results here indicate that the scFv P2B7 is a candidate for inclusion in a mixture of specific antibodies to produce a human anti-bothropic sera. This data demonstrates that the human scFv P2B7 represents an alternative therapeutic approach to heterologous anti-bothropic sera available today.

[Identification of Good-Practice Projects in Promoting Physical Activity - Methods, Pitfalls and Sampled Outcomes].

Science.gov (United States)

Henn, Annette; Karger, Claudia; Wöhlken, Katrin; Meier, Diana; Ungerer-Röhrich, Ulrike; Graf, Christine; Woll, Alexander

2017-03-01

The aim of this paper is to identify and show examples of good practice of public health promotion. For this, uniform quality criteria were worked out under consideration of national and international scientific literature.For the identification of examples of good practice, a comparison of different quality criteria was carried out and combined with each other in a first step. In the following step, examples of good practice were identified after a comprehensive search. The choice of the "good-practice" projects is exemplary and lays no claim to completeness.6 main quality criteria (QC) of programs promoting physical activity could be identified in the national and international context. The analysis showed altogether 10 projects which can exemplarily be classified as examples of good practice of the target groups of children and teenagers, adults, older people and people with pre-existing illnesses. These projects, however, show major differences in their (methodological) quality.The analysis reports a lack of "Good-Practice" examples. Deficits lie mainly in documentation and sustainability. Because of incomplete documentation, an assessment as a "Good-Practice" example is only possible to a limited extent; a lot of information, particularly in the evaluation, is missing. © Georg Thieme Verlag KG Stuttgart · New York.

Cultural Education and the Voluntary Provision of Cultural Goods: An Experimental Study

OpenAIRE

Massimo Finocchiaro Castro

2004-01-01

We study the effect that the possibility of investing in cultural education has on the voluntary contributions to a cultural good. This is done in a two-stage public-good experiment. We also provide treatments with different context in order to control for a possible framing effect. Our results show the absence of an effect of cultural education on the contributions to the cultural good and a slight increase in the allocations of subjectsÂendowments to the cultural good when the cultural cont...

Compliance With Recommended Food Safety Practices in Television Cooking Shows.

Science.gov (United States)

Cohen, Nancy L; Olson, Rita Brennan

Examine compliance with recommended food safety practices in television cooking shows. Using a tool based on the Massachusetts Food Establishment Inspection Report, raters examined 39 episodes from 10 television cooking shows. Chefs demonstrated conformance with good retail practices for proper use and storage of utensils in 78% of episodes; preventing contamination (62%), and fingernail care (82%). However, 50% to 88% of episodes were found to be out of compliance with other personal hygiene practices, proper use of gloves and barriers (85% to 100%), and maintaining proper time and temperature controls (93%). Over 90% failed to conform to recommendations regarding preventing contamination through wiping cloths and washing produce. In only 13% of episodes were food safety practices mentioned. There appears to be little attention to food safety during most cooking shows. Celebrity and competing chefs have the opportunity to model and teach good food safety practices for millions of viewers. Copyright © 2016 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

Papillary Thyroid Cancer: The Good and Bad of the "Good Cancer".

Science.gov (United States)

Randle, Reese W; Bushman, Norah M; Orne, Jason; Balentine, Courtney J; Wendt, Elizabeth; Saucke, Megan; Pitt, Susan C; Macdonald, Cameron L; Connor, Nadine P; Sippel, Rebecca S

2017-07-01

Papillary thyroid cancer is often described as the "good cancer" because of its treatability and relatively favorable survival rates. This study sought to characterize the thoughts of papillary thyroid cancer patients as they relate to having the "good cancer." This qualitative study included 31 papillary thyroid cancer patients enrolled in an ongoing randomized trial. Semi-structured interviews were conducted with participants at the preoperative visit and two weeks, six weeks, six months, and one year after thyroidectomy. Grounded theory was used, inductively coding the first 113 interview transcripts with NVivo 11. The concept of thyroid cancer as "good cancer" emerged unprompted from 94% (n = 29) of participants, mostly concentrated around the time of diagnosis. Patients encountered this perception from healthcare providers, Internet research, friends, and preconceived ideas about other cancers. While patients generally appreciated optimism, this perspective also generated negative feelings. It eased the diagnosis of cancer but created confusion when individual experiences varied from expectations. Despite initially feeling reassured, participants described feeling the "good cancer" characterization invalidated their fears of having cancer. Thyroid cancer patients expressed that they did not want to hear that it's "only thyroid cancer" and that it's "no big deal," because "cancer is cancer," and it is significant. Patients with papillary thyroid cancer commonly confront the perception that their malignancy is "good," but the favorable prognosis and treatability of the disease do not comprehensively represent their cancer fight. The "good cancer" perception is at the root of many mixed and confusing emotions. Clinicians emphasize optimistic outcomes, hoping to comfort, but they might inadvertently invalidate the impact thyroid cancer has on patients' lives.

Democracy, Redistributive Taxation and the Private Provision of Public Goods

DEFF Research Database (Denmark)

Markussen, Thomas

) pointed to, is weakened and might even be reversed in this context. Also, the median voter may choose a negative tax rate, even if he is poorer than the mean, in order to stimulate public goods production. The relevance of the model is illustrated with an application to the finance of higher education.......The paper studies in a simple, Downsian model of political competition how the private provision of public goods is affected when it is embedded in a system of democracy and redistributive taxation. Results show that the positive effect of inequality on public goods production, which Olson (1965...

Veracity in big data: How good is good enough.

Science.gov (United States)

Reimer, Andrew P; Madigan, Elizabeth A

2018-01-01

Veracity, one of the five V's used to describe big data, has received attention when it comes to using electronic medical record data for research purposes. In this perspective article, we discuss the idea of data veracity and associated concepts as it relates to the use of electronic medical record data and administrative data in research. We discuss the idea that electronic medical record data are "good enough" for clinical practice and, as such, are "good enough" for certain applications. We then propose three primary issues to attend to when establishing data veracity: data provenance, cross validation, and context.

A Good Suit Beats a Good Idea.

Science.gov (United States)

Machiavelli, Nick

1992-01-01

Inspired by Niccolo Machiavelli, this column offers beleaguered school executives advice on looking good, dressing well, losing weight, beating the proper enemy, and saying nothing. Administrators who follow these simple rules should have an easier life, jealous colleagues, well-tended gardens, and respectful board members. (MLH)

Memories of good deeds past: The reinforcing power of prosocial behavior in children.

Science.gov (United States)

Tasimi, Arber; Young, Liane

2016-07-01

Does considering one's past prosociality affect future behavior? Prior research has revealed instances in which adults engage in additional prosocial behavior-moral reinforcement-as well as instances in which adults engage in worse behavior-moral licensing. The current study examined the developmental origins of these effects by testing whether 6- to 8-year-old children (N=225) are more or less generous after recalling their own good deeds. Children were asked to recount a time when they were nice, were mean, or watched a movie. Children behaved more generously after recalling a time when they were nice. We show that this boost in generosity was not simply the result of instructing children to consider nice behavior; children's giving did not increase after recalling others' good deeds. We also show that, even after recounting multiple instances of their past goodness, children continue to behave more generously. These findings suggest that doing good leads to more good in children. Copyright © 2016 Elsevier Inc. All rights reserved.

Participative management: Concept and application in consumer goods companies

Directory of Open Access Journals (Sweden)

Ann I Ogbo

2016-11-01

Full Text Available This paper attempts to ascertain the impact of participative management on workflows, its influence on sales output and how well the concept is practised by consumer goods companies in Nigeria. Study adopted the survey design; questionnaires were used to collect necessary data from sales personnel across 10 states in South-Ssouth and South East Nigeria. Respondents rated the concept and application of participative management as it affects their work environment and sales output of the company. Statistical results of the study showed that 92.08% of the respondents believe that there are benefits derivable from participative management and that these benefits improve both sales output and workflow. 48% believe that participative management is practised in firms. Hypotheses tested using the chi-square test statistic revealed that: Consumer goods companies benefit from practising participative management, Participative management has effect on sales output of consumer goods companies, and the concept of participative management is not fully practised by consumer goods companies in Nigeria. These findings indicate that participative management principles need to be inculcated fully in the running of sales organisations so as to increase sales volume and ultimately boost the profit of consumer goods companies

Letting people off the hook: when do good deeds excuse transgressions?

Science.gov (United States)

Effron, Daniel A; Monin, Benoît

2010-12-01

Three studies examined when and why an actor's prior good deeds make observers more willing to excuse--or license--his or her subsequent, morally dubious behavior. In a pilot study, actors' good deeds made participants more forgiving of the actors' subsequent transgressions. In Study 1, participants only licensed blatant transgressions that were in a different domain than actors' good deeds; blatant transgressions in the same domain appeared hypocritical and suppressed licensing (e.g., fighting adolescent drug use excused sexual harassment, but fighting sexual harassment did not). Study 2 replicated these effects and showed that good deeds made observers license ambiguous transgressions (e.g., behavior that might or might not represent sexual harassment) regardless of whether the good deeds and the transgression were in the same or in a different domain--but only same-domain good deeds did so by changing participants' construal of the transgressions. Discussion integrates two models of why licensing occurs.

20 CFR 404.989 - Good cause for reopening.

Science.gov (United States)

2010-04-01

...) The evidence that was considered in making the determination or decision clearly shows on its face... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Good cause for reopening. 404.989 Section 404.989 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY...

Cyclic public goods games: Compensated coexistence among mutual cheaters stabilized by optimized penalty taxation

Science.gov (United States)

Griffin, Christopher; Belmonte, Andrew

2017-05-01

We study the problem of stabilized coexistence in a three-species public goods game in which each species simultaneously contributes to one public good while freeloading off another public good ("cheating"). The proportional population growth is governed by an appropriately modified replicator equation, depending on the returns from the public goods and the cost. We show that the replicator dynamic has at most one interior unstable fixed point and that the population becomes dominated by a single species. We then show that by applying an externally imposed penalty, or "tax" on success can stabilize the interior fixed point, allowing for the symbiotic coexistence of all species. We show that the interior fixed point is the point of globally minimal total population growth in both the taxed and untaxed cases. We then formulate an optimal taxation problem and show that it admits a quasilinearization, resulting in novel necessary conditions for the optimal control. In particular, the optimal control problem governing the tax rate must solve a certain second-order ordinary differential equation.

Good Concrete Activity Is Good Mental Activity

Science.gov (United States)

McDonough, Andrea

2016-01-01

Early years mathematics classrooms can be colourful, exciting, and challenging places of learning. Andrea McDonough and fellow teachers have noticed that some students make good decisions about using materials to assist their problem solving, but this is not always the case. These experiences lead her to ask the following questions: (1) Are…

Quantum chi-squared and goodness of fit testing

Energy Technology Data Exchange (ETDEWEB)

Temme, Kristan [IQIM, California Institute of Technology, Pasadena, California 91125 (United States); Verstraete, Frank [Fakultät für Physik, Universität Wien, Boltzmanngasse 5, 1090 Wien, Austria and Faculty of Science, Ghent University, B-9000 Ghent (Belgium)

2015-01-15

A quantum mechanical hypothesis test is presented for the hypothesis that a certain setup produces a given quantum state. Although the classical and the quantum problems are very much related to each other, the quantum problem is much richer due to the additional optimization over the measurement basis. A goodness of fit test for i.i.d quantum states is developed and a max-min characterization for the optimal measurement is introduced. We find the quantum measurement which leads both to the maximal Pitman and Bahadur efficiencies, and determine the associated divergence rates. We discuss the relationship of the quantum goodness of fit test to the problem of estimating multiple parameters from a density matrix. These problems are found to be closely related and we show that the largest error of an optimal strategy, determined by the smallest eigenvalue of the Fisher information matrix, is given by the divergence rate of the goodness of fit test.

Cooperation and Noise in Public Goods Experiments: Applying the Contribution Function Approach

NARCIS (Netherlands)

Brandts, J.; Schram, A.

2001-01-01

We introduce a new design for experiments with the voluntary contributions mechanism for public goods. Subjects report a complete con-tri-bution function in each period, i.e., a contribution level for various marginal rates of transformation between a public and a private good. The results show that

Effect of the depreciation of public goods in spatial public goods games

Science.gov (United States)

Shi, Dong-Mei; Zhuang, Yong; Wang, Bing-Hong

2012-02-01

In this work, the depreciation effect of public goods is considered in the public goods games, which is realized by rescaling the multiplication factor r of each group as r‧=r( (β≥0). It is assumed that each individual enjoys the full profit r of the public goods if all the players of this group are cooperators. Otherwise, the value of public goods is reduced to r‧. It is found that compared with the original version (β=0), the emergence of cooperation is remarkably promoted for β>0, and there exist intermediate values of β inducing the best cooperation. Particularly, there exists a range of β inducing the highest cooperative level, and this range of β broadens as r increases. It is further presented that the variation of cooperator density with noise has close relations with the values of β and r, and cooperation at an intermediate value of β=1.0 is most tolerant to noise.

Abusing Good Intentions

Directory of Open Access Journals (Sweden)

Tamas Bereczkei

2015-06-01

Full Text Available The present study aims to understand how Machiavellians switch from one kind of response to another in different circumstances to maximize their profit. We set up a specific experimental paradigm that involved both a cooperative and competitive version of a public goods game. We found that Machiavellianism accounts for the total amount of money paid by the players (N = 144 across five rounds in the cooperative but not in the competitive game. Compared with the others, individuals with higher scores on Mach scale contributed less to the public goods in the cooperative condition, but no difference was found in the competitive condition. Finally, this relationship was influenced by the sequence of the games. These results indicate that Machiavellians skillfully evaluate social environments and strive to exploit those with abundant contributions to public goods.

The good midwife: commencing students' views.

Science.gov (United States)

Carolan, Mary

2011-08-01

to explore commencing students' views of the good midwife. This study was set against a background of high course attrition and concerns that discordant students' views of midwifery practice may have been associated with course attrition. qualitative thematic analysis. Melbourne, Australia. all commencing midwifery students, in 2008, were invited to participate (n = 41). students spoke of a series of key attributes they felt were important to the role of the midwife. Most fell into the affective domain and four themes were identified: personal qualities and attitudes; a belief in women and natural birth; compatible work ethic; and the possession of additional attributes. commencing students showed a clear understanding of the affective attributes required of a good midwife but a lesser understanding of requirements of knowledge and competence. A small number of students felt that they were already equipped to advise pregnant women, despite their early stage in the course. This is an issue that needs to be addressed. Copyright © 2010 Elsevier Ltd. All rights reserved.

Kinetic models for goods exchange in a multi-agent market

Science.gov (United States)

Brugna, Carlo; Toscani, Giuseppe

2018-06-01

In this paper we introduce a system of kinetic equations describing an exchange market consisting of two populations of agents (dealers and speculators) expressing the same preferences for two goods, but applying different strategies in their exchanges. Similarly to the model proposed in Toscani et al. (2013), we describe the trading of the goods by means of some fundamental rules in price theory, in particular by using Cobb-Douglas utility functions for the exchange. The strategy of the speculators is to recover maximal utility from the trade by suitably acting on the percentage of goods which are exchanged. This microscopic description leads to a system of linear Boltzmann-type equations for the probability distributions of the goods on the two populations, in which the post-interaction variables depend from the pre-interaction ones in terms of the mean quantities of the goods present in the market. In this case, it is shown analytically that the strategy of the speculators can drive the price of the two goods towards a zone in which there is a branded utility for their group. Also, according to Toscani et al. (2013), the general system of nonlinear kinetic equations of Boltzmann type for the probability distributions of the goods on the two populations is described in details. Numerical experiments then show how the policy of speculators can modify the final price of goods in this nonlinear setting.

Global Public Goods and The Role of Emerging Power: Considering the Concept of Impure Public Goods

Directory of Open Access Journals (Sweden)

Liu Rieshøj Yi

2016-12-01

Full Text Available The existing analysis of global public goods over-emphasizes the significance of public. Great power as a main provider has played an active role in these strategic initiatives, which may be ignored. In fact, main power has thought about the possible free-riders when providing public goods and making its foreign strategic plan. China’s announcement to “welcome the neighbouring countries to be a free-rider and benefit from China’s rise” is a good example. It is necessary to think about the theory of public goods and take another look at the free-riding phenomenon. The concept of impure public goods may be useful and effective when we understand the reason why global public goods are being provided and are relatively efficient. As an emerging power, China should have a clear strategy on global public goods with a possible “marketing” viewpoint, including more initiatives and specific measures, so that the global public goods provision may be more diverse and well-planned.

THE SELLER'S OBLIGATION TO DELIVER THE GOODS ACCORDING TO CISG

Directory of Open Access Journals (Sweden)

Dan VELICU

2017-05-01

Full Text Available This article aims to analyze the seller's obligations under the Convention on International Sale of Goods (CISG and in particular the obligation to deliver the goods showing the main issues that arise in an international sale. We also wish to point the major innovations or improvements brought by the CISG in comparison to the European civil codes regulation and to conclude if the CSIG managed to revolutionize the tradition view on this issue.

Good News in Bad News: How Negativity Enhances Economic Efficacy

OpenAIRE

Svensson, H.M.; Albæk, E.; van Dalen, A.; de Vreese, C.

2017-01-01

Negativity is a news ideology, and its negative effects on attitude formation are widely documented. Contrary to this view, the present study demonstrates that negative economic news can in fact be good news. Based on a two-wave national panel survey and a media content analysis, we show that individual exposure to negative economic news enhances internal economic efficacy, a sense of competence in and understanding of the economy. This is good news as internal economic efficacy may facilitat...

Benchmark Two-Good Utility Functions

NARCIS (Netherlands)

de Jaegher, K.

Benchmark two-good utility functions involving a good with zero income elasticity and unit income elasticity are well known. This paper derives utility functions for the additional benchmark cases where one good has zero cross-price elasticity, unit own-price elasticity, and zero own price

Doing Good, Feeling Bad

DEFF Research Database (Denmark)

Sharma, Devika

2017-01-01

For decades humanitarianism has captured and shaped the dreams of the populations of the global North, dreams of a better world, of a common humanity, of goodness, of solidarity, and of global healing. In this article I argue that when taking art and cultural objects into account humanitarian......, Danmarks Indsamling [Denmark Collects], and the second is from Norwegian playwright Arne Lygre’s 2011 play, I Disappear. What is at stake in both of these scenes is the status of humanitarianism as a good-enough fantasy and promise of doing good....

Design of a robotic automation system for transportation of goods in hospitals

DEFF Research Database (Denmark)

Özkil, Ali Gürcan; Sørensen, Torben; Fan, Zhun

2007-01-01

Hospitals face with heavy traffic of goods everyday, where transportation tasks are mainly carried by human. Analysis of the current situation of transportation in a typical hospital showed several transportation tasks are suitable for automation. This paper presents a system, consisting of a fleet...... of robot vehicles, automatic stations and smart containers for automation of transportation of goods in hospitals. Design of semi-autonomous robot vehicles, containers and stations are presented and the overall system architecture is described. Implementing such a system in an existing hospital showed...

When being narrow minded is a good thing: locally biased people show stronger contextual cueing.

Science.gov (United States)

Bellaera, Lauren; von Mühlenen, Adrian; Watson, Derrick G

2014-01-01

Repeated contexts allow us to find relevant information more easily. Learning such contexts has been proposed to depend upon either global processing of the repeated contexts, or alternatively processing of the local region surrounding the target information. In this study, we measured the extent to which observers were by default biased to process towards a more global or local level. The findings showed that the ability to use context to help guide their search was strongly related to an observer's local/global processing bias. Locally biased people could use context to help improve their search better than globally biased people. The results suggest that the extent to which context can be used depends crucially on the observer's attentional bias and thus also to factors and influences that can change this bias.

Stability engineering of anti-EGFR scFv antibodies by rational design of a lambda-to-kappa swap of the VL framework using a structure-guided approach.

Science.gov (United States)

Lehmann, Andreas; Wixted, Josephine H F; Shapovalov, Maxim V; Roder, Heinrich; Dunbrack, Roland L; Robinson, Matthew K

2015-01-01

Phage-display technology facilitates rapid selection of antigen-specific single-chain variable fragment (scFv) antibodies from large recombinant libraries. ScFv antibodies, composed of a VH and VL domain, are readily engineered into multimeric formats for the development of diagnostics and targeted therapies. However, the recombinant nature of the selection strategy can result in VH and VL domains with sub-optimal biophysical properties, such as reduced thermodynamic stability and enhanced aggregation propensity, which lead to poor production and limited application. We found that the C10 anti-epidermal growth factor receptor (EGFR) scFv, and its affinity mutant, P2224, exhibit weak production from E. coli. Interestingly, these scFv contain a fusion of lambda3 and lambda1 V-region (LV3 and LV1) genes, most likely the result of a PCR aberration during library construction. To enhance the biophysical properties of these scFvs, we utilized a structure-based approach to replace and redesign the pre-existing framework of the VL domain to one that best pairs with the existing VH. We describe a method to exchange lambda sequences with a more stable kappa3 framework (KV3) within the VL domain that incorporates the original lambda DE-loop. The resulting scFvs, C10KV3_LV1DE and P2224KV3_LV1DE, are more thermodynamically stable and easier to produce from bacterial culture. Additionally, C10KV3_LV1DE and P2224KV3_LV1DE retain binding affinity to EGFR, suggesting that such a dramatic framework swap does not significantly affect scFv binding. We provide here a novel strategy for redesigning the light chain of problematic scFvs to enhance their stability and therapeutic applicability.

STRATEGIC ALIGNMENT THROUGH COMPETITIVE PRIORITIES IN CAPITAL GOODS COMPANIES

Directory of Open Access Journals (Sweden)

Prof. Dr. Roberto Giro Moori

2014-08-01

Full Text Available The purpose of this paper is to ascertain the strategic alignment of companies producing capital goods and deploying competitive priorities, from the standpoint of dyadic relationships.  To collect the data, semi-structured questionnaires were used for a sample consisting of 113 respondents from 87 companies producing capital goods, all operating in Brazil. The data were analyzed using non-parametric statistical techniques. More specifically, an analysis of Kendall’s coefficient of concordance (W showed that product (or component price and performance are the main competitive priorities for companies in this sector. Thus, evidence was found that companies producing capital goods are strategically aligned from the standpoint of dyadic relationships with their suppliers and customers, with price being the main criterion, depending on the downstream focus of the company, through the performance of the product (or component.

Sociocultural Transformation & Development. Good Practices or Successful Actions

Directory of Open Access Journals (Sweden)

Oriol Ríos

2013-10-01

Full Text Available The most disadvantadged neighborhoods in Europe have received funds from State Administration to eradicate social exclusion and overcome processes of urban ghettoization. These processes are being implemented in several social areas such as housing, employment, and education. Actions, defined as "good practices", are usually valued by the quantity and type and not by the quality and final outcomes they achieve. For example, when they improve the living conditions of the populations in these areas. The INCLUD-ED project shows positive results by replacing these "good practices" by "successful actions". They are grounded on scientific evidence in order to respond to the aims set by the neighbours of these disadvantaged neighborhoods.

Screening of synthetic phage display scFv libraries yields competitive ligands of human leptin receptor.

Science.gov (United States)

Molek, Peter; Vodnik, Miha; Strukelj, Borut; Bratkovič, Tomaž

2014-09-26

Initially considered the main endogenous anorexigenic factor, fat-derived leptin turned out to be a markedly pleiotropic hormone, influencing diverse physiological processes. Moreover, hyperleptinemia in obese individuals has been linked to the onset or progression of serious disorders, such as cancer, autoimmune diseases, and atherosclerosis, and antagonizing peripheral leptin's signalization has been shown to improve these conditions. To develop an antibody-based leptin antagonist we have devised a tailored panning procedure and screened two phage display libraries of single chain variable antibody fragments (scFvs) against recombinant leptin receptor. One of the scFvs was expressed in Escherichia coli and its interaction with leptin receptor was characterized in more detail. It was found to recognize a discontinuous epitope and to compete with leptin for receptor binding with IC50 and Kd values in the nanomolar range. The reported scFv represents a lead for development of leptin antagonists that may ultimately find use in therapy of various hyperleptinemia-related disorders. Copyright © 2014 Elsevier Inc. All rights reserved.

Advice on Good Grooming.

Science.gov (United States)

Tingey, Carol

1987-01-01

Suggestions are presented from parents on how to help children with disabilities (with particular focus on Downs Syndrome) learn good grooming habits in such areas as good health, exercise, cleanliness, teeth and hair care, skin care, glasses and other devices, and social behavior. (CB)

Customs control of goods

Directory of Open Access Journals (Sweden)

Mentor Gashi

2015-11-01

Full Text Available Customs control, is regulated by law in different countries. Different countries define through the law, the control of goods.. Main purpose of this paper is to analyze two types of customs controls, and their effect in reducing avoidance of duty or tax evasion which may be caused by the import of goods of certain companies. For this reason we researched which model is implemented in developing countries and what results were reached through questionnaires. In this sense the next research question, consists in defining the moment of customs control pre or post-clearance control of goods.

TRANSPORT OF COUNTERFEIT GOODS

Directory of Open Access Journals (Sweden)

Dagmar Babčanová

2014-09-01

Full Text Available The paper is focused on a current problem of transport of counterfeit goods in the European Union. Counterfeiting has a strong influence on the distribution organizations worldwide because most of counterfeit goods threaten the health and safety of consumers. Counterfeiting is a serious problem in the world economy today. The purpose of this paper is to point out the danger of counterfeiting in connection with the transport of Intellectual Property (IP rights - infringing goods. Background of the paper’s content is based on secondary data research of publicly available sources - international statistics and world reports.

An overview of GOOD

NARCIS (Netherlands)

Paredaens, J.; Van den Bussche, J.; Andries, M.; Gemis, M.; Gyssens, M.; Thyssens, I.; Van Gucht, D.; Sarathy, V.; Saxton, L.V.

1992-01-01

GOOD is an acronym, standing for Graph-Oriented Object Database. GOOD is being developed as a joint research effort of Indiana University and the University of Antwerp. The main thrust behind the project is to indicate general concepts that are fundamental to any graph-oriented database

The Public Goods Hypothesis for the evolution of life on Earth.

Science.gov (United States)

McInerney, James O; Pisani, Davide; Bapteste, Eric; O'Connell, Mary J

2011-08-23

It is becoming increasingly difficult to reconcile the observed extent of horizontal gene transfers with the central metaphor of a great tree uniting all evolving entities on the planet. In this manuscript we describe the Public Goods Hypothesis and show that it is appropriate in order to describe biological evolution on the planet. According to this hypothesis, nucleotide sequences (genes, promoters, exons, etc.) are simply seen as goods, passed from organism to organism through both vertical and horizontal transfer. Public goods sequences are defined by having the properties of being largely non-excludable (no organism can be effectively prevented from accessing these sequences) and non-rival (while such a sequence is being used by one organism it is also available for use by another organism). The universal nature of genetic systems ensures that such non-excludable sequences exist and non-excludability explains why we see a myriad of genes in different combinations in sequenced genomes. There are three features of the public goods hypothesis. Firstly, segments of DNA are seen as public goods, available for all organisms to integrate into their genomes. Secondly, we expect the evolution of mechanisms for DNA sharing and of defense mechanisms against DNA intrusion in genomes. Thirdly, we expect that we do not see a global tree-like pattern. Instead, we expect local tree-like patterns to emerge from the combination of a commonage of genes and vertical inheritance of genomes by cell division. Indeed, while genes are theoretically public goods, in reality, some genes are excludable, particularly, though not only, when they have variant genetic codes or behave as coalition or club goods, available for all organisms of a coalition to integrate into their genomes, and non-rival within the club. We view the Tree of Life hypothesis as a regionalized instance of the Public Goods hypothesis, just like classical mechanics and euclidean geometry are seen as regionalized

The public goods hypothesis for the evolution of life on Earth

LENUS (Irish Health Repository)

McInerney, James O

2011-08-23

Abstract It is becoming increasingly difficult to reconcile the observed extent of horizontal gene transfers with the central metaphor of a great tree uniting all evolving entities on the planet. In this manuscript we describe the Public Goods Hypothesis and show that it is appropriate in order to describe biological evolution on the planet. According to this hypothesis, nucleotide sequences (genes, promoters, exons, etc.) are simply seen as goods, passed from organism to organism through both vertical and horizontal transfer. Public goods sequences are defined by having the properties of being largely non-excludable (no organism can be effectively prevented from accessing these sequences) and non-rival (while such a sequence is being used by one organism it is also available for use by another organism). The universal nature of genetic systems ensures that such non-excludable sequences exist and non-excludability explains why we see a myriad of genes in different combinations in sequenced genomes. There are three features of the public goods hypothesis. Firstly, segments of DNA are seen as public goods, available for all organisms to integrate into their genomes. Secondly, we expect the evolution of mechanisms for DNA sharing and of defense mechanisms against DNA intrusion in genomes. Thirdly, we expect that we do not see a global tree-like pattern. Instead, we expect local tree-like patterns to emerge from the combination of a commonage of genes and vertical inheritance of genomes by cell division. Indeed, while genes are theoretically public goods, in reality, some genes are excludable, particularly, though not only, when they have variant genetic codes or behave as coalition or club goods, available for all organisms of a coalition to integrate into their genomes, and non-rival within the club. We view the Tree of Life hypothesis as a regionalized instance of the Public Goods hypothesis, just like classical mechanics and euclidean geometry are seen as

Behavioral Patterns in Special Education. Good Teaching Practices.

Science.gov (United States)

Rodríguez-Dorta, Manuela; Borges, África

2017-01-01

Providing quality education means to respond to the diversity in the classroom. The teacher is a key figure in responding to the various educational needs presented by students. Specifically, special education professionals are of great importance as they are the ones who lend their support to regular classroom teachers and offer specialized educational assistance to students who require it. Therefore, special education is different from what takes place in the regular classroom, demanding greater commitment by the teacher. There are certain behaviors, considered good teaching practices, which teachers have always been connected with to achieve good teaching and good learning. To ensure that these teachers are carrying out their educational work properly it is necessary to evaluate. This means having appropriate instruments. The Observational Protocol for Teaching Functions in Primary School and Special Education (PROFUNDO-EPE, v.3., in Spanish) allows to capture behaviors from these professionals and behavioral patterns that correspond to good teaching practices. This study evaluates the behavior of two special education teachers who work with students from different educational stages and educational needs. It reveals that the analyzed teachers adapt their behavior according the needs and characteristics of their students to the students responding more adequately to the needs presented by the students and showing good teaching practices. The patterns obtained indicate that they offer support, help and clear guidelines to perform the tasks. They motivate them toward learning by providing positive feedback and they check that students have properly assimilated the contents through questions or non-verbal supervision. Also, they provide a safe and reliable climate for learning.

Survivors of cardiac arrest with good neurological outcome show considerable impairments of memory functioning.

Science.gov (United States)

Sulzgruber, Patrick; Kliegel, Andreas; Wandaller, Cosima; Uray, Thomas; Losert, Heidrun; Laggner, Anton N; Sterz, Fritz; Kliegel, Matthias

2015-03-01

Deficits in cognitive function are a well-known dysfunction in survivors of cardiac arrest. However, data concerning memory function in this neurological vulnerable patient collective remain scarce and inconclusive. Therefore, we aimed to assess multiple aspects of retrospective and prospective memory performance in patients after cardiac arrest. We prospectively enrolled 33 survivors of cardiac arrest, with cerebral performance categories (CPC) 1 and 2 and a control-group (n=33) matched in sex, age and educational-level. To assess retrospective and prospective memory performance we administrated 4 weeks after cardiac arrest the "Rey Adult Learning Test" (RAVLT), the "Digit-Span-Backwards Test", the "Logic-Memory Test" and the "Red-Pencil Test". Results indicate an impairment in immediate and delayed free recall, but not in recognition. However, the overall impairment in immediate recall was qualified by analyzing RAVLT performance, showing that patients were only impaired in trials 4 and 5 of the learning sequence. Moreover, working and prospective memory as well as prose recall were worse in cardiac arrest survivors. Cranial computed tomography was available in 61% of all patients (n=20) but there was no specific neurological damage detectable that could be linked to this cognitive impairment. Episodic long-term memory functioning appears to be particularly impaired after cardiac arrest. In contrast, short-term memory storage, even tested via free-call, seems not to be affected. Based on cranial computed tomography we suggest that global brain ischemia rather than focal brain lesions appear to underlie these effects. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Transportation of hazardous goods

CERN Multimedia

TS Department

2008-01-01

A general reminder: any transportation of hazardous goods by road is subject to the European ADR rules. The goods concerned are essentially the following: Explosive substances and objects; Gases (including aerosols and non-flammable gases such as helium and nitrogen); Flammable substances and liquids (inks, paints, resins, petroleum products, alcohols, acetone, thinners); Toxic substances (acids, thinners); Radioactive substances; Corrosive substances (paints, acids, caustic products, disinfectants, electrical batteries). Any requests for the transport of hazardous goods must be executed in compliance with the instructions given at this URL: http://ts-dep.web.cern.ch/ts-dep/groups/he/HH/adr.pdf Heavy Handling Section TS-HE-HH 73793 - 160364

Incremental Design of Perishable Goods Markets through Multi-Agent Simulations

Directory of Open Access Journals (Sweden)

Kazuo Miyashita

2017-12-01

Full Text Available In current markets of perishable goods such as fish and vegetables, sellers are typically in a weak bargaining position, since perishable products cannot be stored for long without losing their value. To avoid the risk of spoiling products, sellers have few alternatives other than selling their goods at the prices offered by buyers in the markets. The market mechanism needs to be reformed in order to resolve unfairness between sellers and buyers. Double auction markets, which collect bids from both sides of the trades and match them, allow sellers to participate proactively in the price-making process. However, in perishable goods markets, sellers have an incentive to discount their bid gradually for fear of spoiling unsold goods. Buyers can take advantage of sellers’ discounted bids to increase their profit by strategic bidding. To solve the problem, we incrementally improve an online double auction mechanism for perishable goods markets, which promotes buyers’ truthful bidding by penalizing their failed bids without harming their individual rationality. We evaluate traders’ behavior under several market conditions using multi-agent simulations and show that the developed mechanism achieves fair resource allocation among traders.

The global public good concept: a means of promoting good veterinary governance.

Science.gov (United States)

Eloit, M

2012-08-01

At the outset, the concept of a 'public good' was associated with economic policies. However, it has now evolved not only from a national to a global concept (global public good), but also from a concept applying solely to the production of goods to one encompassing societal issues (education, environment, etc.) and fundamental rights, including the right to health and food. Through their actions, Veterinary Services, as defined by the Terrestrial Animal Health Code (Terrestrial Code) of the World Organisation for Animal Health (OIE), help to improve animal health and reduce production losses. In this way they contribute directly and indirectly to food security and to safeguarding human health and economic resources. The organisation and operating procedures of Veterinary Services are therefore key to the efficient governance required to achieve these objectives. The OIE is a major player in global cooperation and governance in the fields of animal and public health through the implementation of its strategic standardisation mission and other programmes for the benefit of Veterinary Services and OIE Member Countries. Thus, the actions of Veterinary Services and the OIE deserve to be recognised as a global public good, backed by public investment to ensure that all Veterinary Services are in a position to apply the principles of good governance and to comply with the international standards for the quality of Veterinary Services set out in the OIE Terrestrial Code (Section 3 on Quality of Veterinary Services) and Aquatic Animal Health Code (Section 3 on Quality of Aquatic Animal Health Services).

Efficacy, Beliefs, and Investment in Step-Level Public Goods

NARCIS (Netherlands)

Dijkstra, Jacob; Mulders, Jaap Oude

2014-01-01

A central concept for understanding social dilemma behavior is the efficacy of an actor's cooperative behavior in terms of increasing group well-being. We report a decision and game theoretical analysis of efficacy in step-level public goods (SPGs). Previous research shows a positive relation

Monitoring Dangerous Goods in Container Yard Using the Internet of Things

Directory of Open Access Journals (Sweden)

Lianhong Ding

2016-01-01

Full Text Available The Internet of Things (IoT, a network of objects, has been regarded as the next revolution for the global information industry after the Internet. With IoT, many intelligent applications can be accomplished or improved. This paper presents a framework for dangerous goods management in container yard using IoT technology. The framework consists of three layers: perceptual layer, transport layer, and application layer. It offers an infrastructure for management and data analysis and utilization. According to the features of dangerous goods, the framework can be enhanced for container information forecast, container gate-in and gate-out management, environment parameters monitoring, and fire control as well. In order to verify our method, a prototype system is developed, which shows good performance. With our method, safe operation of dangerous goods in container yard can be accomplished.

Paradoxes around good governance

NARCIS (Netherlands)

A.G. Dijkstra (Geske)

2013-01-01

textabstract Good governance is not a new concept Ambrogio Lorenzetti made his frescoes on good and bad governance already in the years 1338-1340 They can be viewed in the Palazzo Publicco on one of the most beautiful squares of the world, the Piazza del Campo in Siena, Italy I assume many of you

"Act in Good Faith."

Science.gov (United States)

McKay, Robert B.

1979-01-01

It is argued that the Supreme Court's Bakke decision overturning the University of California's minority admissions program is good for those who favor affirmative action programs in higher education. The Supreme Court gives wide latitude for devising programs that take race and ethnic background into account if colleges are acting in good faith.…

42 CFR 93.210 - Good faith.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Good faith. 93.210 Section 93.210 Public Health... MISCONDUCT Definitions § 93.210 Good faith. Good faith as applied to a complainant or witness, means having a... allegation or cooperation with a research misconduct proceeding is not in good faith if made with knowing or...

Efficacy, Beliefs, and Investment in Step-Level Public Goods

NARCIS (Netherlands)

Dijkstra, J.; Oude Mulders, J.

2014-01-01

behavior in terms of increasing group well-being. We report a decision and game theoretical analysis of efficacy in step-level public goods (SPGs). Previous research shows a positive relation between efficacy and contributions to SPGs and explains this relation by a purely motivational account. We

18 CFR 2.20 - Good faith requests for transmission services and good faith responses by transmitting utilities.

Science.gov (United States)

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Good faith requests for transmission services and good faith responses by transmitting utilities. 2.20 Section 2.20 Conservation of... Power Act § 2.20 Good faith requests for transmission services and good faith responses by transmitting...

Conceptions of Good Teaching by Good Teachers: Case Studies from an Australian University

Science.gov (United States)

Duarte, Fernanda P.

2013-01-01

This paper contributes to the debate on what constitutes good teaching in early 21st Century higher education, through an examination of the experience of five outstanding lecturers from a business school in an Australian university. It is based on a qualitative study that explored their perceptions on what constitutes "good teaching".…

Asymmetric News Effects on Volatility: Good vs. Bad News in Good vs. Bad Times

OpenAIRE

Laakkonen, Helinä; Lanne, Markku

2008-01-01

We study the impact of positive and negative macroeconomic US and European news announcements in different phases of the business cycle on the highfrequency volatility of the EUR/USD exchange rate. The results suggest that in general bad news increases volatility more than good news. The news effects also depend on the state of the economy: bad news increases volatility more in good times than in bad times, while there is no difference between the volatility effects of good news in bad and go...

Reading comprehension and expressive writing: a comparison between good and poor comprehenders.

Science.gov (United States)

Carretti, Barbara; Re, Anna Maria; Arfè, Barbara

2013-01-01

This study investigated expressive writing in 8- to 10-year-old children with different levels of reading comprehension. Poor and good comprehenders were presented with three expressive writing tasks where the modality (pictorial vs. verbal) and the text genre (narrative vs. descriptive) varied. Results showed that poor comprehenders' performance was minimally influenced by the modality of the prompt. In fact, their performance was generally worse than that of good comprehenders and affected by the text genre, as the quality of their narratives was generally lower than that of good comprehenders. However, in the descriptive text condition, their performance was comparable to that of good comprehenders. One can conclude that their problems depend on the characteristics of the narrative text where coherence and causality are important elements.

'She sort of shines': midwives' accounts of 'good' midwifery and 'good' leadership.

Science.gov (United States)

Byrom, Sheena; Downe, Soo

2010-02-01

to explore midwives' accounts of the characteristics of 'good' leadership and 'good' midwifery. a phenomenological interview survey. Participants were asked about what made both good and poor midwives and leaders. two maternity departments within National Health Service trusts in the North West of England. qualified midwives, selected by random sampling stratified to encompass senior and junior grades. thematic analysis, carried out manually. ten midwives were interviewed. Sixteen codes and six sub-themes were generated. Across the responses, two clear dimensions (themes) were identified, relating on the one hand to aspects of knowledge, skill and competence (termed 'skilled competence'), and on the other hand to specific personality characteristics (termed 'emotional intelligence'). This study suggests that the ability to act knowledgeably, safely and competently was seen as a basic requirement for both clinical midwives and midwife leaders. The added element which made both the midwife and the leader 'good' was the extent of their emotional capability. this small-scale in-depth study could form the basis for hypothesis generation for larger scale work in this area in future. The findings offer some reinforcement for the potential applicability of theories of transformational leadership to midwifery management and practice. Copyright 2008 Elsevier Ltd. All rights reserved.

How to solve the tragedy of the commons? Social entrepreneurs and global public goods

DEFF Research Database (Denmark)

Ueda, Yoshifumi; Svendsen, Gert Tinggaard

2002-01-01

and efficacy of financing a global public good on a local scale is analyzed in a "selective incentive-cum-global public good" model. Because local networks can play a significant role in preserving the global commons, this finding has important policy implications for global public good provisions......We show that when a star type network is formed by an entrepreneur, a non-profit organization run by a social entrepreneur is more reconcilable with the social objective of providing the global public good than a profit organization run by a business entrepreneur. This network formation...

MARKET RESEARCH OF CARE GOODS FOR NEWBORNS AND FIRST YEAR CHILDREN

Directory of Open Access Journals (Sweden)

A. I. Ovod

2015-01-01

Full Text Available Comparative results of marketing research of care goods for newborns and first year children conducted in 2009 and 2014 showed that there were changes in the range of products and consumer preferences. The analysis revealed that the economic situation affected the determinants of choice in this category of goods and the location of purchasing. The findings should be considered by pharmaceutical companies in their procurement in order to improve their competitive position. 

Moral identity and the experience of moral elevation in response to acts of uncommon goodness.

Science.gov (United States)

Aquino, Karl; McFerran, Brent; Laven, Marjorie

2011-04-01

Four studies using survey and experimental designs examined whether people whose moral identity is highly self-defining are more susceptible to experiencing a state of moral elevation after being exposed to acts of uncommon moral goodness. Moral elevation consists of a suite of responses that motivate prosocial action tendencies. Study 1 showed that people higher (vs. lower) in moral identity centrality reported experiencing more intense elevating emotions, had more positive views of humanity, and were more desirous of becoming a better person after reading about an act of uncommon goodness than about a merely positive situation or an act of common benevolence. Study 2 showed that those high in moral identity centrality were more likely to recall acts of moral goodness and experience moral elevation in response to such events more strongly. These experiences were positively related to self-reported prosocial behavior. Study 3 showed a direct effect on behavior using manipulated, rather than measured, moral identity centrality. Study 4 replicated the effect of moral identity on the states of elevation as well as on self-reported physical sensations and showed that the elevation mediates the relationship between moral identity, witnessing uncommon goodness, and prosocial behavior.

Good Faith

DEFF Research Database (Denmark)

Fomcenco, Alex

2017-01-01

This article outlines the current state of law in Canada in respect to good faith in contratial relations. The topic is highly relevant due to expected growth in the numbers of contracts concluded between European and Canadian enterprises in the wake of adoption of the Comprehensive Economic...

GOOD GOVERNANCE AND TRANSFORMATION

Directory of Open Access Journals (Sweden)

Hans-Jürgen WAGENER

2005-12-01

Full Text Available Transformation of a totalitarian, basically administratively coordinated system into a democratic one that is coordinated predominantly by markets and competition has been triggered by, among others, the perception of a serious deficit in welfare and happiness. Public policy has a special task transforming the economic order by liberalisation, privatisation, stabilisation and the installation of institutions that are supportive for competition. After 15 years since transformation began, there are sufficiently differentiated success stories to test the hypothesis: it was good governance that is responsible for success and bad governance for failure. The empirical results support the “Lorenzetti hypothesis”: where freedom, security and trust prevail, the economy flourishes, where they are lacking, the costs of long-term investment are too high. The initial conditions of transition countries seem to be quite similar, nevertheless, even there one can discern good and bad governance. The extent of socialist lawfulness, planning security, cronyism and corruption differed widely between East Berlin and Tashkent. And a good deal of such variations can be found in the pre-socialist history of these countries. However, the main conclusion is that the co-evolution hypothesis states that both, welfare and good governance, go together.

TENDENCIES OF REGIONAL ELITE GOODS MARKET DEVELOPMENT

Directory of Open Access Journals (Sweden)

A.I. Tatarkin

2008-03-01

Full Text Available During the period of planned economy only a limited section of society with high social status had an access to elite goods in our country. At present an access to these goods is not regulated, and elite goods trade market in Russia is developing rapidly. In the article the essence of "elite good" and "regional elite goods market" concepts is defined, the classification of elite goods markets is given, also the main factors and tendencies of elite goods market development in the Ural Region is analyzed.

Conjugated Linoleic Acid: good or bad nutrient

Directory of Open Access Journals (Sweden)

Gonçalves Daniela C

2010-10-01

Full Text Available Abstract Conjugated linoleic acid (CLA is a class of 28 positional and geometric isomers of linoleic acid octadecadienoic.Currently, it has been described many benefits related to the supplementation of CLA in animals and humans, as in the treatment of cancer, oxidative stress, in atherosclerosis, in bone formation and composition in obesity, in diabetes and the immune system. However, our results show that, CLA appears to be not a good supplement in patients with cachexia.

Adaptive play stabilizes cooperation in continuous public goods games

Science.gov (United States)

Wu, Te; Wang, Long

2018-04-01

We construct a model to study the effects of repeated interaction on the evolution of cooperation in continuous public goods games. Instead of preassigning the duration of repeatedness, the likelihood of group entering next round interaction is positively dependent on the group's current cooperativeness. Meanwhile, when the disturbance happens, the interaction terminates. Under rare mutations, we show that such adaptive play can lead to the dominance of full cooperative state for weak disturbance. For fairly strong disturbance, all-or-none cooperative states share higher fractions of time in the long run, results similar to the ones reported in the study (Pinheiro et al., 2014) while differing from the ones reported in another relevant study (Van Segbroeck et al., 2012), although only strategy space and way determining next round vary. Our results remain valid when groups enter next round with a given probability independent of groups' cooperativeness. In the synergic public goods games, the positive effects of repeated interactions on promoting cooperation is further strengthened. In the discounted public goods game, only very weak disturbance can lead to the dominance of full cooperative state while fairly strong disturbance can favor both full cooperative state and a partially cooperative state. Our study thus enriches the literature on the evolution of cooperation in repeated public goods games.

Fab-based bispecific antibody formats with robust biophysical properties and biological activity.

Science.gov (United States)

Wu, Xiufeng; Sereno, Arlene J; Huang, Flora; Lewis, Steven M; Lieu, Ricky L; Weldon, Caroline; Torres, Carina; Fine, Cody; Batt, Micheal A; Fitchett, Jonathan R; Glasebrook, Andrew L; Kuhlman, Brian; Demarest, Stephen J

2015-01-01

A myriad of innovative bispecific antibody (BsAb) platforms have been reported. Most require significant protein engineering to be viable from a development and manufacturing perspective. Single-chain variable fragments (scFvs) and diabodies that consist only of antibody variable domains have been used as building blocks for making BsAbs for decades. The drawback with Fv-only moieties is that they lack the native-like interactions with CH1/CL domains that make antibody Fab regions stable and soluble. Here, we utilize a redesigned Fab interface to explore 2 novel Fab-based BsAbs platforms. The redesigned Fab interface designs limit heavy and light chain mixing when 2 Fabs are co-expressed simultaneously, thus allowing the use of 2 different Fabs within a BsAb construct without the requirement of one or more scFvs. We describe the stability and activity of a HER2×HER2 IgG-Fab BsAb, and compare its biophysical and activity properties with those of an IgG-scFv that utilizes the variable domains of the same parental antibodies. We also generated an EGFR × CD3 tandem Fab protein with a similar format to a tandem scFv (otherwise known as a bispecific T cell engager or BiTE). We show that the Fab-based BsAbs have superior biophysical properties compared to the scFv-based BsAbs. Additionally, the Fab-based BsAbs do not simply recapitulate the activity of their scFv counterparts, but are shown to possess unique biological activity.

Development of an Indirect Competitive Enzyme-Linked Immunosorbent Assay for Glycocholic Acid Based on Chicken Single-Chain Variable Fragment Antibodies.

Science.gov (United States)

Cui, Xiping; Vasylieva, Natalia; Wu, Panpan; Barnych, Bogdan; Yang, Jun; Shen, Ding; He, Qiyi; Gee, Shirley J; Zhao, Suqing; Hammock, Bruce D

2017-10-17

Glycocholic acid (GCA) is an important metabolite of bile acids, whose urine levels are expected to be a specific diagnostic biomarker for hepatocellular carcinoma (HCC). A high-throughput immunoassay for determination of GCA would be of significant advantage and useful for primary diagnosis, surveillance, and early detection of HCC. Single-chain variable fragment (scFv) antibodies have several desirable characteristics and are an attractive alternative to traditional antibodies for the immunoassay. Because chicken antibodies possess single heavy and light variable functional domains, they are an ideal framework for simplified generation of recombinant antibodies for GCA detection. However, chicken scFvs have rarely been used to detect GCA. In this study, a scFv library was generated from chickens immunized with a GCA hapten coupled to bovine serum albumin (BSA), and anti-GCA scFvs were isolated by a phage-displayed method. Compared to the homologous coating antigen, use of a heterologous coating antigen resulted in about an 85-fold improvement in sensitivity of the immunoassay. This assay, under optimized conditions, had a linear range of 0.02-0.18 μg/mL, with an IC 50 of 0.06 μg/mL. The assay showed negligible cross-reactivity with various related bile acids, except for taurocholic acid. The detection of GCA from spiked human urine samples ranged from 86.7% to 123.3%. These results, combined with the advantages of scFv antibodies, indicated that a chicken scFv-based enzyme-linked immunosorbent assay is a suitable method for high-throughput screening of GCA in human urine.

Conspicuous Public Goods and Leadership Selection

NARCIS (Netherlands)

Jennings, C.; Roelfsema, H.J.

If voters care for the relative supply of public goods compared to otherjurisdictions, decentralized provision of public goods will be too high.Potentially, centralization internalizes the negative externalities fromthe production of these `conspicuous' public goods. However, in amodel of strategic

A note on goodness of fit test using moments

Directory of Open Access Journals (Sweden)

Alex Papadopoulos

2007-10-01

Full Text Available The purpose of this article is to introduce a general moment-based approach to derive formal goodness of fit tests of a parametric family. We show that, in general, an approximate normal test or a chi-squared test can be derived by exploring the moment structure of a parametric family, when moments up to certain order exist. The idea is simple and the resulting tests are easy to implement. To illustrate the use of this approach, we derive moment-based goodness of fit tests for some common discrete and continuous parametric families. We also compare the proposed tests with the well known Pearson-Fisher chi-square test and some distance tests in a simulation study.

Good governance as perceived by Dabawenyos

Directory of Open Access Journals (Sweden)

Adrian M. Tamayo

2016-12-01

Full Text Available The debate on good governance had shaped public policies of many governments. This study was conducted to obtain latent perspectives of good governance. A survey was conducted using two-stage cluster sampling in the first congressional district of Davao City involving 351 respondents. Findings reveal that the notion of good governance of Dabawenyos is primarily a government to implement the rule of law; peace and order is a necessity to facilitate market efficiency. Also, it was found that political leadership creates notions of good governance; public bestowed power to its political leaders as a matter of trust. On the other hand, leaders incorporate soft and hard forms of power in delegating powers without losing control, causing a widespread and significant impact on the formation and development of Davao’s perspectives of good governance. This is the rubber band effect of good governance leadership.

On jointly optimising the changes of seasonable goods and inventory replenishment

Science.gov (United States)

Li, Zhaolin; Tao, Feng; Sun, Daewon

2012-06-01

Retailers often need to replace soon-to-be-unseasonable products with new seasonable goods when the season changes. The trade-off for such activities involves choosing between the salvage loss of the unseasonable product and the profit of selling the seasonable product early. This article develops a periodic-review inventory model for planning the changes of seasonable goods with state-dependent demand and cost parameters. We show that the single-period optimal policy for product changes is a threshold policy based on the initial inventory of the unseasonable goods. The corresponding optimal inventory policy follows a Purchase-Keep-Dispose policy if the incumbent product is kept or a base-stock policy if the incumbent product is replaced. Numerically, we find that the structure of the multi-period optimal policy resembles that of the single-period model. We propose a heuristic to solve the multi-period model and demonstrate its effectiveness. Our research provides insights into dynamically managing seasonable goods.

The Relational Nature of the Good

OpenAIRE

Korsgaard, Christine M.

2013-01-01

This chapter argues that the relation of being good-for someone is prior to the property of being good. After discussing the views of Moore, Geach, Foot, and Rawls, the author argues that there are final goods because there are conscious animals. Hedonists also believe this, but think of goodness as an intrinsic property of certain conscious states—pleasant ones. This is because they mistake pleasure for sensation and so for an object of experience. After advancing an alternative conception o...

Correlated equilibria in homogenous good Bertrand competition

DEFF Research Database (Denmark)

Jann, Ole; Schottmüller, Christoph

2015-01-01

We show that there is a unique correlated equilibrium, identical to the unique Nash equilibrium, in the classic Bertrand oligopoly model with homogenous goods and identical marginal costs. This provides a theoretical underpinning for the so-called "Bertrand paradox'' as well as its most general f...... formulation to date. Our proof generalizes to asymmetric marginal costs and arbitrarily many players in the following way: The market price cannot be higher than the second lowest marginal cost in any correlated equilibrium....

HSP60 may predict good pathological response to neoadjuvant chemoradiotherapy in bladder cancer

International Nuclear Information System (INIS)

Urushibara, Masayasu; Kageyama, Yukio; Akashi, Takumi; Otsuka, Yukihiro; Takizawa, Touichiro; Koike, Morio; Kihara, Kazunori

2007-01-01

Heat shock proteins (HSPs) play crucial roles in cellular responses to stressful conditions. Expression of HSPs in invasive or high-risk superficial bladder cancer was investigated to identify whether HSPs predict pathological response to neoadjuvant chemoradiotherapy (CRT). Immunohistochemistry was used to assess expression levels of HSP27, HSP60, HSP70, HSP90 and p53 in 54 patients with invasive or high-risk superficial bladder cancer, prior to low-dose neoadjuvant CRT, followed by radical or partial cystectomy. Patients were classified into two groups (good or poor responders) depending on pathological response to CRT, which was defined as the proportion of morphological therapeutic changes in surgical specimens. Good responders showed morphological therapeutic changes in two-thirds or more of tumor tissues. In contrast, poor responders showed changes in less than two-thirds of tumor tissues. Using a multivariate analysis, positive HSP60 expression prior to CRT was found to be marginally associated with good pathological response to CRT (P=0.0564). None of clinicopathological factors was associated with HSP60 expression level. In the good pathological responders, the 5-year cause-specific survival was 88%, which was significantly better than survival in the poor responders (51%) (P=0.0373). Positive HSP60 expression prior to CRT may predict good pathological response to low-dose neoadjuvant CRT in invasive or high-risk superficial bladder cancer. (author)

Reconsidering the “Good Divorce”

Science.gov (United States)

Amato, Paul R.; Kane, Jennifer B.; James, Spencer

2011-01-01

This study attempted to assess the notion that a “good divorce” protects children from the potential negative consequences of marital dissolution. A cluster analysis of data on postdivorce parenting from 944 families resulted in three groups: cooperative coparenting, parallel parenting, and single parenting. Children in the cooperative coparenting (good divorce) cluster had the smallest number of behavior problems and the closest ties to their fathers. Nevertheless, children in this cluster did not score significantly better than other children on 10 additional outcomes. These findings provide only modest support for the good divorce hypothesis. PMID:22125355

Good Towers of Function Fields

DEFF Research Database (Denmark)

Bassa, Alp; Beelen, Peter; Nguyen, Nhut

2014-01-01

In this paper, we will give an overview of known and new techniques on how one can obtain explicit equations for candidates of good towers of function fields. The techniques are founded in modular theory (both the classical modular theory and the Drinfeld modular theory). In the classical modular...... setup, optimal towers can be obtained, while in the Drinfeld modular setup, good towers over any non-prime field may be found. We illustrate the theory with several examples, thus explaining some known towers as well as giving new examples of good explicitly defined towers of function fields....

How Good is OpenMP

Directory of Open Access Journals (Sweden)

Timothy G. Mattson

2003-01-01

Full Text Available The OpenMP standard defines an Application Programming Interface (API for shared memory computers. Since its introduction in 1997, it has grown to become one of the most commonly used API's for parallel programming. But success in the market doesn't necessarily imply successful computer science. Is OpenMP a "good" programming environment? What does it even mean to call a programming environment good? And finally, once we understand how good or bad OpenMP is; what can we do to make it even better? In this paper, we will address these questions.

Development of anti-bovine IgA single chain variable fragment and its application in diagnosis of foot-and-mouth disease

Science.gov (United States)

Sridevi, N. V.; Shukra, A. M.; Neelakantam, B.; Anilkumar, J.; Madhanmohan, M.; Rajan, S.; Dev Chandran

2014-01-01

Recombinant antibody fragments like single chain variable fragments (scFvs) represent an attractive yet powerful alternative to immunoglobulins and hold great potential in the development of clinical diagnostic/therapeutic reagents. Structurally, scFvs are the smallest antibody fragments capable of retaining the antigen-binding capacity of whole antibodies and are composed of an immunoglobulin (Ig) variable light (VL) and variable heavy (VH) chain joined by a flexible polypeptide linker. In the present study, we constructed a scFv against bovine IgA from a hybridoma cell line IL-A71 that secretes a monoclonal antibody against bovine IgA using recombinant DNA technology. The scFv was expressed in Escherichia coli and purified using immobilized metal affinity chromatography (IMAC). The binding activity and specificity of the scFv was established by its non-reactivity toward other classes of immunoglobulins as determined by enzyme-linked immunosorbent assay (ELISA) and immunoblot analysis. Kinetic measurement of the scFv indicated that the recombinant antibody fragment had an affinity in picomolar range toward purified IgA. Furthermore, the scFv was used to develop a sensitive ELISA for the detection of foot and mouth disease virus (FMDV) carrier animals. PMID:24678404

Use of micro-emulsion technology for the directed evolution of antibodies.

Science.gov (United States)

Buhr, Diane L; Acca, Felicity E; Holland, Erika G; Johnson, Katie; Maksymiuk, Gail M; Vaill, Ada; Kay, Brian K; Weitz, David A; Weiner, Michael P; Kiss, Margaret M

2012-09-01

Affinity reagents, such as antibodies, are needed to study protein expression patterns, sub-cellular localization, and post-translational modifications in complex mixtures and tissues. Phage Emulsion, Secretion, and Capture (ESCape) is a novel micro-emulsion technology that utilizes water-in-oil (W/O) emulsions for the identification and isolation of cells secreting phage particles that display desirable antibodies. Using this method, a large library of antibody-displaying phage will bind to beads in individual compartments. Rather than using biopanning on a large mixed population, phage micro-emulsion technology allows us to individually query clonal populations of amplified phage against the antigen. The use of emulsions to generate microdroplets has the promise of accelerating phage selection experiments by permitting fine discrimination of kinetic parameters for binding to targets. In this study, we demonstrate the ability of phage micro-emulsion technology to distinguish two scFvs with a 300-fold difference in binding affinities (100nM and 300pM, respectively). In addition, we describe the application of phage micro-emulsion technology for the selection of scFvs that are resistant to elevated temperatures. Copyright © 2012. Published by Elsevier Inc.

Trade in Cultural Goods: A Case of the Korean Wave in Asia

Directory of Open Access Journals (Sweden)

Young Seaon Park

2014-03-01

Full Text Available This paper studies the effects of economic development and cultural proximity as common determinants of trade in cultural goods in a dynamic preference selection model. For the empirical analysis, this paper utilizes the gravity framework with importer fixed effects and Poisson pseudo-maximum likelihood estimators. This paper applies the model to Korean export of broadcasting contents to Asian countries. The relative economic development of the export country and the market size of the import country are important determinants of cultural trade, the results of which are generally consistent with traditional goods trade. However, the distance variable does not show much significance, reflecting the unique characteristics of trade in cultural goods.

Bad is stronger than good

NARCIS (Netherlands)

Baumeister, R.F.; Bratslavsky, E.; Finkenauer, C.; Vohs, K.D.

2001-01-01

The greater power of bad events over good ones is found in everyday events, major life events (e.g., trauma), close relationship outcomes, social network patterns, interpersonal interactions, and learning processes. Bad emotions, bad parents, and bad feedback have more impact than good ones, and bad

Generating and exploring good building layouts

KAUST Repository

Bao, Fan

2013-07-16

Good building layouts are required to conform to regulatory guidelines, while meeting certain quality measures. While different methods can sample the space of such good layouts, there exists little support for a user to understand and systematically explore the samples. Starting from a discrete set of good layouts, we analytically characterize the local shape space of good layouts around each initial layout, compactly encode these spaces, and link them to support transitions across the different local spaces. We represent such transitions in the form of a portal graph. The user can then use the portal graph, along with the family of local shape spaces, to globally and locally explore the space of good building layouts. We use our framework on a variety of different test scenarios to showcase an intuitive design, navigation, and exploration interface. Copyright © ACM. Copyright © ACM 2013.

7 CFR 51.1011 - Good green color.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Good green color. 51.1011 Section 51.1011 Agriculture... Standards for Persian (Tahiti) Limes Definitions § 51.1011 Good green color. Good green color means that the skin of the lime is of a good green color characteristic of the Persian variety. ...

Solving optimization problems by the public goods game

Science.gov (United States)

Javarone, Marco Alberto

2017-09-01

We introduce a method based on the Public Goods Game for solving optimization tasks. In particular, we focus on the Traveling Salesman Problem, i.e. a NP-hard problem whose search space exponentially grows increasing the number of cities. The proposed method considers a population whose agents are provided with a random solution to the given problem. In doing so, agents interact by playing the Public Goods Game using the fitness of their solution as currency of the game. Notably, agents with better solutions provide higher contributions, while those with lower ones tend to imitate the solution of richer agents for increasing their fitness. Numerical simulations show that the proposed method allows to compute exact solutions, and suboptimal ones, in the considered search spaces. As result, beyond to propose a new heuristic for combinatorial optimization problems, our work aims to highlight the potentiality of evolutionary game theory beyond its current horizons.

29 CFR 570.128 - Good faith defense.

Science.gov (United States)

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Good faith defense. 570.128 Section 570.128 Labor... Provisions of the Fair Labor Standards Act of 1938, as Amended Enforcement § 570.128 Good faith defense. Link... commerce goods which he acquired in good faith in reliance on written assurance from the producer...

12 CFR 220.6 - Good faith account.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Good faith account. 220.6 Section 220.6 Banks... BY BROKERS AND DEALERS (REGULATION T) § 220.6 Good faith account. In a good faith account, a creditor...) Securities entitled to good faith margin—(1) Permissible transactions. A creditor may effect and finance...

Good News in Bad News: How Negativity Enhances Economic Efficacy

NARCIS (Netherlands)

Svensson, H.M.; Albæk, E.; van Dalen, A.; de Vreese, C.

2017-01-01

Negativity is a news ideology, and its negative effects on attitude formation are widely documented. Contrary to this view, the present study demonstrates that negative economic news can in fact be good news. Based on a two-wave national panel survey and a media content analysis, we show that

Good for God? Religious motivation reduces perceived responsibility for and morality of good deeds.

Science.gov (United States)

Gervais, Will M

2014-08-01

Many people view religion as a crucial source of morality. However, 6 experiments (total N = 1,078) revealed that good deeds are perceived as less moral if they are performed for religious reasons. Religiously motivated acts were seen as less moral than the exact same acts performed for other reasons (Experiments 1-2 and 6). Religious motivations also reduced attributions of intention and responsibility (Experiments 3-6), an effect that fully mediated the effect of religious motivations on perceived morality (Experiment 6). The effects were not explained by different perceptions of motivation orientation (i.e., intrinsic vs. extrinsic) across conditions (Experiment 4) and also were evident when religious upbringing led to an intuitive moral response (Experiment 5). Effects generalized across religious and nonreligious participants. When viewing a religiously motivated good deed, people infer that actually helping others is, in part, a side effect of other motivations rather than an end in itself. Thus, religiously motivated actors are seen as less responsible than secular actors for their good deeds, and their helping behavior is viewed as less moral than identical good deeds performed for either unclear or secular motivations. PsycINFO Database Record (c) 2014 APA, all rights reserved.

The Essence of Good Teaching.

Science.gov (United States)

Sherman, Robert R.

1986-01-01

Compares and contrasts views of what constitutes good teaching in four recent books: "My Harvard, My Yale: Memoirs of College Life by Some Notable Americans" (Dubois, 1982); "Twenty Teachers" (Macrorie, 1984); "Artistry in Teaching" (Rubin, 1985); and "The Essence of Good Teaching: Helping Students Learn and Remember What They Learn" (Eriksen,…

Differences in autonomic physiological responses between good and poor inductive reasoners.

Science.gov (United States)

Melis, C; van Boxtel, A

2001-11-01

We investigated individual- and task-related differences in autonomic physiological responses induced by time limited figural and verbal inductive reasoning tasks. In a group of 52 participants, the percentage of correctly responded task items was evaluated together with nine different autonomic physiological response measures and respiration rate (RR). Weighted multidimensional scaling analyses of the physiological responses revealed three underlying dimensions, primarily characterized by RR, parasympathetic, and sympathetic activity. RR and sympathetic activity appeared to be relatively more important response dimensions for poor reasoners, whereas parasympathetic responsivity was relatively more important for good reasoners. These results suggest that poor reasoners showed higher levels of cognitive processing intensity than good reasoners. Furthermore, for the good reasoners, the dimension of sympathetic activity was relatively more important during the figural than during the verbal reasoning task, which was explained in terms of hemispheric lateralization in autonomic function.

[The myth of the good savage].

Science.gov (United States)

Yampey, N

1994-09-01

The conquest of the New World gave way to the myth of the Good Savage. For the Renaissance intellectuals, the ancient ideas about the Golden Age (an ideal society promising an unending bliss) seemed to be brought back to life at last. Sharply contrasting with the European exacerbated unrest of the time, America stood for a redeeming hope, a symbol of a better future. The myth of the Good Savage assumes people to be naturally good, but civilization has led them into the realm of violence, hatred, and cruelty. Besides being naturally good, nice-minded people, "good savages" were also useful, obedient people, most likely to be easily exploited by Europeans--a source for the historical drama to come. On the verge of freeing itself from the Spanish rule, Latin America--fighting its way toward independence, had three enlightened mentors: Voltaire, Rousseau, and Montesquieu. There, again, another deep contrast arose between the abstract characteristics of Latin American aims to perfection, and people's actual behaviors. The former "good savage" became the modern "Latin American" embodying an utopia as well as a hope in his eagerness for setting up a plural, and humanized culture. The myth of the Good Savage represents a deep longing for an objectivation of the ego-ideal: it has been used, so to speak, in collective mobilizations as well as dogmatic crystallizations, to escape from ignominous realities or to project alternatives for a better socially-shared life.

Good Governance According to Islamic Perspective

Directory of Open Access Journals (Sweden)

Mohamad Ismail Bin Mohamad Yunus

2018-02-01

Full Text Available Abstract The objectives of the professional agencies must embody provisions that promote good governance and embrace values of integrity and accountability and seek support from the public and the government of the day to provide an independent view on all matters. The universal truth is that everything should be done in the public good. Professionals form the backbone of human infrastructure in any economy, politics, social and legal growth. Their contributions through professional performance enhance the good delivery system that facilitates policies making and management for public sector. They provide the skills and talent in balancing the pursuits of maximization of services. The expression “good governance” has been constantly used lately in both public sector as well as private sector in Malaysia. In the context of a private body, it should be within the framework of the statute, which governs the body and also its constitution. In the public sector, it means that the administrators should act professionally and not to abuse or misuse the power or authority given to them. They are regarded as the trustees of the public at large. The scope of this article is on good public governance in the public sector or to be exact, good governmental administration as interpreted by the judiciary especially through its judicial review power and Islamic Perspective based on the principles of Maqasid As Shariah (Objectives of Islamic Law.   Keywords: Good Governance, Public Sector, Malaysian Law, Islamic Perspective, Maqasid As-Shariah.

The Common Good in Classical Political Philosophy

Science.gov (United States)

Lewis, V. Bradley

2006-01-01

The term "common good" names the end (or final cause) of political and social life in the tradition of moral thought that owes its main substance to Aristotle and St. Thomas Aquinas. It names a genuine good ("bonum honestum") and not merely an instrumental or secondary good defeasible in the face of particular goods. However, at the same time, it…

Considering capital goods in life cycle assessments by input-output analysis. Offshore wind farm as an application example

International Nuclear Information System (INIS)

Eickelkamp, Timo

2013-01-01

Capital goods are not normally taken into consideration in assessing the sustainability of products on the basis of life cycle assessments. Capital goods are machines and buildings that are used for production purposes over the course of a product's life cycle. Using an offshore wind farm as an example the present study shows how capital goods can be taken into account via a methodologically expanded input-output analysis and thus factored into the life cycle assessment. Besides comparing different calculation methods the author performs a detailed analysis of those parameters with the greatest influence on the outcome. The results show that capital goods have a substantial impact on sustainability in both energy-related and environmental terms. Capital goods should therefore be taken into consideration in life cycle assessments.

From Goods to Solutions

DEFF Research Database (Denmark)

Chakkol, Mehmet; Johnson, Mark; Raja, Jawwad

2014-01-01

Purpose – This paper aims to adopt service-dominant logic (SDL) to empirically explore network configurations resulting from the provision of goods, goods and services, and solutions. Design/methodology/approach – This paper uses a single, in-depth, exploratory case study in a truck manufacturer......: dyadic, triadic and tetradic. The extent to which different network actors contribute to value co-creation varies across the offerings. Research limitations/implications – This paper is based on a single, in-depth case study developed in one industrial context. Whilst this represents an appropriate...

Paying for International Environmental Public Goods

OpenAIRE

Arriagada, Rodrigo; Perrings, Charles

2011-01-01

Supply of international environmental public goods must meet certain conditions to be socially efficient, and several reasons explain why they are currently undersupplied. Diagnosis of the public goods failure associated with particular ecosystem services is critical to the development of the appropriate international response. There are two categories of international environmental public goods that are most likely to be undersupplied. One has an additive supply technology and the other has ...

Robots, Disability, and Good Human Life

Directory of Open Access Journals (Sweden)

Antonio Carnevale

2015-02-01

Full Text Available In this paper, I want to show the role that emerging robotic technologies could play in the future in daily life of disabled people. When I talk about disability, I mean any temporary or permanent limitation due to a chronic disease and deficit, as well as, socially disadvantaged conditions, which imply functional and emotional restrictions experienced at any age. All these limitations can be characterized by a specific mental and physical impairment or, more often, by a cluster of medical impairments and social barriers. To this end, the academic literature has generally differentiated between two disability models: 'medical' versus 'social'. The main attempt of this paper consists into showing how the development of robotic technologies — particularly in assistive and healthcare fields — could allow us to go beyond this outdated dichotomy, contributing to create new philosophical premises to rethink the universality of the human condition, that is, the sense of what we intend for 'good human life'.

Students' and teachers' cognitions about good teachers.

Science.gov (United States)

Beishuizen, J J; Hof, E; van Putten, C M; Bouwmeester, S; Asscher, J J

2001-06-01

Good teachers have been studied ever since Plato described how Socrates taught by asking questions of his audience. Recent findings shed light on two characteristics of good teachers: their personality and their ability. However, more attention has been paid to teachers' practices and opinions than to students' views. The study reported here attempted to deepen our understanding of what students think about good teachers. Students of four age groups (7, 10, 13, and 16 years of age) and teachers from primary and secondary schools were asked to write an essay on the good teacher. The correspondence between conceptual items in the essays was investigated by determining the extent to which they were used in the same essays to describe good teachers. Correspondence analysis revealed two dimensions. The first dimension reflected the preference of students and teachers for describing the good teacher in terms of either personality or ability characteristics. The second dimension was interpreted as an orientation in the essays towards either attachment to, detachment from or commitment to school and teachers. Students and teachers were compared to establish the amount of (dis)agreement about what makes a good teacher. Primary school students described good teachers primarily as competent instructors, focusing on transfer of knowledge and skills, whereas secondary school students emphasised relational aspects of good teachers. Teachers, however, considered good teachers in the first place a matter of establishing personal relationships with their students. Consequently, primary school students and teachers disagreed about the characteristics of good teachers. In secondary education, disagreements between teachers and students were relatively small. The research method of collecting free essays and utilising correspondence analysis to represent conceptual items and groups of participants seems promising as long as a theoretical framework is available to interpret the

Nudge for (the Public) Good: How Defaults Can Affect Cooperation.

Science.gov (United States)

Fosgaard, Toke R; Piovesan, Marco

2015-01-01

In this paper we test the effect of non-binding defaults on the level of contribution to a public good. We manipulate the default numbers appearing on the decision screen to nudge subjects toward a free-rider strategy or a perfect conditional cooperator strategy. Our results show that the vast majority of our subjects did not adopt the default numbers, but their stated strategy was affected by the default. Moreover, we find that our manipulation spilled over to a subsequent repeated public goods game where default was not manipulated. Here we found that subjects who previously saw the free rider default were significantly less cooperative than those who saw the perfect conditional cooperator default.

Nudge for (the Public Good: How Defaults Can Affect Cooperation.

Directory of Open Access Journals (Sweden)

Toke R Fosgaard

Full Text Available In this paper we test the effect of non-binding defaults on the level of contribution to a public good. We manipulate the default numbers appearing on the decision screen to nudge subjects toward a free-rider strategy or a perfect conditional cooperator strategy. Our results show that the vast majority of our subjects did not adopt the default numbers, but their stated strategy was affected by the default. Moreover, we find that our manipulation spilled over to a subsequent repeated public goods game where default was not manipulated. Here we found that subjects who previously saw the free rider default were significantly less cooperative than those who saw the perfect conditional cooperator default.

A Theory of Finitely Durable Goods Monopoly with Used-Goods Market and Transaction Costs

OpenAIRE

S. Huang; Y. Yang; K. Anderson

2001-01-01

We construct a dynamic game to model a monopoly of finitely durable goods. The solution concept is Markov-perfect equilibria with general equilibria embedded in every time period. Our model is flexible enough to simultaneously explain or accommodate many commonly observed phenomena or stylized facts, such as concurrent leasing and selling, active secondary markets for used goods, heterogeneous consumers, endogenous consumption patterns, depreciation, an infinite time horizon, and nontrivial t...

Good Practices for Transforming Education

Science.gov (United States)

Benavente, Ana; Panchaud, Christine

2008-01-01

This text is a guide to the reading and interpretation of the "good practices" that are developing in the countries participating in this project and elsewhere. A systematic approach to the factors making up a "good practice" has enabled us to share our analyses in a more structured manner and to reflect on their potential for…

Why Quorum Sensing Controls Private Goods

Directory of Open Access Journals (Sweden)

Martin Schuster

2017-05-01

Full Text Available Cell-cell communication, also termed quorum sensing (QS, is a widespread process that coordinates gene expression in bacterial populations. The generally accepted view is that QS optimizes the cell density-dependent benefit attained from cooperative behaviors, often in the form of secreted products referred to as “public goods.” This view is challenged by an increasing number of cell-associated products or “private goods” reported to be under QS-control for which a collective benefit is not apparent. A prominent example is nucleoside hydrolase from Pseudomonas aeruginosa, a periplasmic enzyme that catabolizes adenosine. Several recent studies have shown that private goods can function to stabilize cooperation by co-regulated public goods, seemingly explaining their control by QS. Here we argue that this property is a by-product of selection for other benefits rather than an adaptation. Emphasizing ecophysiological context, we propose alternative explanations for the QS control of private goods. We suggest that the benefit attained from private goods is associated with high cell density, either because a relevant ecological condition correlates with density, or because the private good is, directly or indirectly, involved in cooperative behavior. Our analysis helps guide a systems approach to QS, with implications for antivirulence drug design and synthetic biology.

Everybody needs good neighbours

Energy Technology Data Exchange (ETDEWEB)

Hoffman, G. [Peabody Energy (United States)

2006-05-15

The paper outlines the possibilities for mines to work with surrounding communities to bring about effective land reclamation. Last year Peabody Energy teams reclaimed more than 5000 acres of land and planted nearly 750,000 trees, demonstrating that sustainable development is possible in a way that is compatible with environmental improvement in coal mining. The company has won over 20 awards over the last two years. The North Antelope Rochelle Mine in Wyoming earned a Gold Good Neighbour Award for promoting best practices in environmental conservation and mining education. The Black Mesa and Kayenta mines, which operate on Navajo and Hopi lands in Arizona, were honoured with a Silver Good Neighbour Award and a National Excellence in Mining and Reclamation Award. These mines partnered with the tribes, the Bureau of Indian Affairs and local residents to give residents access to grazing land still under Peabody's control. The Farmersburg Mine in Indiana received the Bronze Good Neighbour Award for commitment to industry education and outreach activities. 5 photos.

Business Climate and Good Governance

Directory of Open Access Journals (Sweden)

Besmira Manaj

2015-03-01

Full Text Available This paper consists of three factors, namely: Good Governance, Business Climate and Corruption. How they affect the development product of Albania, not only as a concept, and a principle but mostly as a sensitive aspect in the integration process. There are some interpretations of this concept, but I intend to analyze the key factors and actors, their cooperation and concrete production in society. Improving governance is necessary to have an integrated long term strategy based upon a continuous cooperation between institutions and citizens. But in developing countries like Albania there are some important questions such as: How can we measure the improvement of Good Governance through policies? Has Good Governance indicated an effective way for the sustainable development? (Meisel, 2008, 6. These question give us the orientation to reflect about the process of development, social economic political behavior and how this multidimensional is transformed in product of good governance. The business cycle is strongly connected with many aspects of political-, social-, juridical aspects and good governance. Despite attempts to draft law regulations, the level of corruption and informality in Albania continues to be a major obstacle. The credibility level in the implementation of law is an indicator that affects democratization and institutional integration. At present, different reports of international institutions, define Albania as the country with the highest level of Corruption in the Balkans, which is a key factor influencing business. The ways with

19 CFR 10.594 - Originating goods.

Science.gov (United States)

2010-04-01

... States Free Trade Agreement Rules of Origin § 10.594 Originating goods. Except as otherwise provided in... good otherwise satisfies any applicable regional value content or other requirements specified in...

Microbial platform technology for recombinant antibody fragment production: A review.

Science.gov (United States)

Gupta, Sanjeev Kumar; Shukla, Pratyoosh

2017-02-01

Recombinant antibody fragments are being used for the last few years as an important therapeutic protein to cure various critical and life threatening human diseases. Several expression platforms now days employed for the production of these recombinant fragments, out of which bacterial system has emerged a promising host for higher expression. Since, a small antibody fragment unlike full antibody does not require human-like post-translational modification therefore it is potentially expressed in prokaryotic production system. Recently, small antibody fragments such as scFvs (single-chain variable fragments) and Fabs (antibody fragments) which does not require glycosylation are successfully produced in bacteria and have commercially launched for therapeutic use as these fragments shows better tissue penetration and less immunogenic to human body compared to full-size antibody. Recently developed Wacker's ESETEC secretion technology is an efficient technology for the expression and secretion of the antibody fragment (Fab) exceeded up to 4.0 g/L while scFv up to 3.5 g/L into the fermentation broth. The Pfenex system and pOP prokaryotic expression vector are another platform used for the considerably good amount of antibody fragment production successfully. In this review, we summarize the recent progress on various expression platforms and cloning approaches for the production of different forms of antibody fragments in E. coli.

Good performance in nuclear projects

International Nuclear Information System (INIS)

1989-01-01

The nuclear industry has demonstrated good performance in many areas relating to the design, engineering, construction and operation of nuclear facilities. This report of an international symposium held in Tokyo highlights examples of good performance in nuclear projects which can aid the industry in seeking even better performance, thus strengthening the contribution nuclear energy can make to sustainable economic growth

ENVIRONMENTAL RISK ASSESSMENT OF SOME COPPER BASED FUNGICIDES ACCORDING TO THE REQUIREMENTS OF GOOD LABORATORY PRACTICE

Directory of Open Access Journals (Sweden)

Marga GRĂDILĂ

2015-10-01

Full Text Available The paper presents data demonstrating the functionality of biological systems reconstituted with aquatic organisms developed under Good Laboratory Practice testing facility within Research - Development Institute for Plant Protection Bucharest for environmental risk assessment of four fungicides based on copper, according to Good Laboratory Practice requirements. For risk assessment, according to GLP were made the following steps: Good Laboratory Practice test facility was established, we have ensured adequate space for growth, acclimatization and testing for each test species, it was installed a complex water production instalation needed to perform tests, it was achieved control system for checking environmental conditions and have developed specific operating procedures that have been accredited according to Good Laboratory Practice.The results showed that biological systems model of the Good Laboratory Practice test facility in Research - Development Institute for Plant Protection meet the requirements of Organisation for Economic Co-operation and Development Guidelines regarding GLP, and after testing copper-based fungicides in terms of acute toxicity Cyprinus carpio and to Daphnia magna revealed that three of them (copper oxychloride, copper hydroxide and copper sulphate showed ecological efficiency, ie low toxicity. Metallic copper based fungicides showed a higher toxicity, resulting in fish toxicity symptoms: sleep, sudden immersion, faded, weakness, swimming in spiral, lack of balance, breathing slow and cumbersome, spasms and mortality.

“All the good and nothing less”: Consumption of Luxury Goods among the bottom of the pyramid

Directory of Open Access Journals (Sweden)

Danielle Soutilha de Souza

2013-04-01

Full Text Available The Brazilian middle class has undergone significant growth in recent years accounting for 52% of the population. Precisely because of this phenomenon, we became interested in this research that is focused on women living in Rio de Janeiro. Although there are many recent research in marketing about the consumer habits of this class, mainly due to the increase in their purchasing power, the particularities of the various groups within this large mass and how they behave in face of consumption expected from social elites, such as luxury goods was under explored. This research aims to contribute to a more detailed exploration on this population. In order to observe the production of knowledge and the process of identity construction of women surveyed, the theme was the consumption of luxury goods. Three categories are presented relevant: Luxury, Luxury at Day by Day and Dream and Consumption, which bring distinct and complementary information for a better understanding of the analyzed group. Although traditional theories about luxury present social status, differentiation and hedonism as main reasons for the consumption of these objects, other relevant aspects were observed for this type of consumer, the family being the great arena where most of the social and economic relations happen. The research also shows the development of a peculiar look to fashion by the study group being key to understanding what is luxury. The results of this study show the richness of practices and meanings of consumption within the same group and the importance of a qualitative look for academics and managers in the field of marketing to really understand the phenomena of consumption in modern societies, especially societies that are having a great social and economic development as Brazil.

Good Teachers, Good Schools: How to Create a Successful School

Science.gov (United States)

Hudson, David

2009-01-01

"Good schools think 'with' people and not 'to' people" argues David Hudson in this thought provoking practical guide for those wanting to bridge the gap between middle and senior management roles, and make a difference in their schools. Accessibly and engagingly written and packed with real-life examples, this book will prove essential…

Niacin to Boost Your HDL "Good" Cholesterol

Science.gov (United States)

Niacin can boost 'good' cholesterol Niacin is a B vitamin that may raise your HDL ("good") cholesterol. But side effects might outweigh benefits for most ... been used to increase high-density lipoprotein (HDL) cholesterol — the "good" cholesterol that helps remove low-density ...

The ESDP and Good Practices of Local Development in Peripheral Areas

DEFF Research Database (Denmark)

Gallina, Andrea; Capecchi, Vittorio

shows that the EU documents concerned with spatial planning and regional development suffer from a strong ambiguity in the choice of the development model (either neoliberal or solidaristic economy) both within Europe and in relation with Third countries. Through the analysis of selected good practices...

Continuous-Time Public Good Contribution Under Uncertainty: A Stochastic Control Approach

International Nuclear Information System (INIS)

Ferrari, Giorgio; Riedel, Frank; Steg, Jan-Henrik

2017-01-01

In this paper we study continuous-time stochastic control problems with both monotone and classical controls motivated by the so-called public good contribution problem. That is the problem of n economic agents aiming to maximize their expected utility allocating initial wealth over a given time period between private consumption and irreversible contributions to increase the level of some public good. We investigate the corresponding social planner problem and the case of strategic interaction between the agents, i.e. the public good contribution game. We show existence and uniqueness of the social planner’s optimal policy, we characterize it by necessary and sufficient stochastic Kuhn–Tucker conditions and we provide its expression in terms of the unique optional solution of a stochastic backward equation. Similar stochastic first order conditions prove to be very useful for studying any Nash equilibria of the public good contribution game. In the symmetric case they allow us to prove (qualitative) uniqueness of the Nash equilibrium, which we again construct as the unique optional solution of a stochastic backward equation. We finally also provide a detailed analysis of the so-called free rider effect.

Continuous-Time Public Good Contribution Under Uncertainty: A Stochastic Control Approach

Energy Technology Data Exchange (ETDEWEB)

Ferrari, Giorgio, E-mail: giorgio.ferrari@uni-bielefeld.de; Riedel, Frank, E-mail: frank.riedel@uni-bielefeld.de; Steg, Jan-Henrik, E-mail: jsteg@uni-bielefeld.de [Bielefeld University, Center for Mathematical Economics (Germany)

2017-06-15

In this paper we study continuous-time stochastic control problems with both monotone and classical controls motivated by the so-called public good contribution problem. That is the problem of n economic agents aiming to maximize their expected utility allocating initial wealth over a given time period between private consumption and irreversible contributions to increase the level of some public good. We investigate the corresponding social planner problem and the case of strategic interaction between the agents, i.e. the public good contribution game. We show existence and uniqueness of the social planner’s optimal policy, we characterize it by necessary and sufficient stochastic Kuhn–Tucker conditions and we provide its expression in terms of the unique optional solution of a stochastic backward equation. Similar stochastic first order conditions prove to be very useful for studying any Nash equilibria of the public good contribution game. In the symmetric case they allow us to prove (qualitative) uniqueness of the Nash equilibrium, which we again construct as the unique optional solution of a stochastic backward equation. We finally also provide a detailed analysis of the so-called free rider effect.

BEHAVIOR OF THE ROMANIAN GREEN GOODS CONSUMERS

Directory of Open Access Journals (Sweden)

Mirela-Cristina VOICU

2014-05-01

Full Text Available Marketing has put forward for a long time the fact that any activity conducted in an organization should consider an intimate knowledge of the client, and a close look at the green marketing practices used over time shows that eco-friendly products should be positioned in relation to those attributes looked for by the involved consumers. In this context, the following paper reveals some important aspects regarding the Romanian green market and the characteristics of the green consumer behavior together with solutions that marketers can apply to stimulate the consumption of green goods.

R&W Club Frederick Hosts Second Annual Car Show | Poster

Science.gov (United States)

A 1994 Ford Thunderbird, a 2006 Porsche 911-S, and a 1996 Chevy Camaro Z28 were just a few of the rides on display this summer at R&W Club Frederick’s second annual Car and Motorcycle Show. “It’s a chance to raise money for a good cause,” said Geoff Seidel, one of the organizers of the event and program director for the Coordinating Center for Clinical Trials, NCI Office of

Generating and exploring good building layouts

KAUST Repository

Bao, Fan; Yan, Dongming; Mitra, Niloy J.; Wonka, Peter

2013-01-01

Good building layouts are required to conform to regulatory guidelines, while meeting certain quality measures. While different methods can sample the space of such good layouts, there exists little support for a user to understand

Governing for the Common Good.

Science.gov (United States)

Ruger, Jennifer Prah

2015-12-01

The proper object of global health governance (GHG) should be the common good, ensuring that all people have the opportunity to flourish. A well-organized global society that promotes the common good is to everyone's advantage. Enabling people to flourish includes enabling their ability to be healthy. Thus, we must assess health governance by its effectiveness in enhancing health capabilities. Current GHG fails to support human flourishing, diminishes health capabilities and thus does not serve the common good. The provincial globalism theory of health governance proposes a Global Health Constitution and an accompanying Global Institute of Health and Medicine that together propose to transform health governance. Multiple lines of empirical research suggest that these institutions would be effective, offering the most promising path to a healthier, more just world.

High School Students’ Perception of the Concept of ‘Good Citizen

Directory of Open Access Journals (Sweden)

Emin KILINÇ

2013-11-01

consisting of two sections was constructed based on Davies, Gregory and Riley’s (1999 work. The first section requested standard demographic information from high school students. The second section of the survey instrument included two tasks: 1 main characteristics of good citizen 2 elements that have effects on development on good citizenship knowledge, skills and behaviors. The participants were selected through cluster random sampling during the 2012- 2013 school year in the city of Uşak. A total of 552 high school students participated in this research. The data were analyzed through descriptive analysis, independent sample t test and one-way analysis of varience (ANOVA in SPSS 20 statistical package program. The result of the study showed that three distinct characteristics of good citizenship emerged from the quantitative analysis of high school students responses: 1 social concern characteristics, 2 Knowledge characteristics, 3 conservative characteristics. According to the result, high school students expressed that social concern characteristics are the most important characteristics of good citizen than other characteristics. The findings also indicated that there is a significant difference between male and female high school students on social concern characteristics. Female students more considered social concern than male students. Another findings showed that there are significant differences between school types on social concern characteristics. The results also demonstrate that there is a significant difference between male and female high school students on knowledge characteristics of good citizen. Also, there are significant differences between school types on knowledge characteristics.

Transport of hazardous goods. Befoerderung gefaehrlicher Gueter

Energy Technology Data Exchange (ETDEWEB)

1989-01-01

The course 'Transport of hazardous goods' was held in Berlin in November 1988 in cooperation with the Bundesanstalt fuer Materialforschung und -pruefung. From all lecturs, two are recorded separately: 'Safety of tank trucks - requirements on the tank, development possibiities of active and passive safety' and 'Requirements on the transport of radioactive materials - possible derivations for other hazardous goods'. The other lectures deal with hazardous goods law, requirements on packinging, risk assessment, railroad transport, hazardous goods road network, insurance matters, EC regulations, and waste tourism. (HSCH).

The Biochemistry Show: a new and fun tool for learning

Directory of Open Access Journals (Sweden)

A.H Ono

2006-07-01

Full Text Available The traditional methods to teach biochemistry in most universities are based on the memorization of chemical structures,  biochemical  pathways  and  reagent  names,  which  is  many  times  dismotivating  for  the  students.  We presently describe an innovative, interactive and alternative method for teaching biochemistry to medical and nutrition undergraduate students, called the Biochemistry Show (BioBio Show.The Biobio show is based on active participation of the students. They are divided in groups and the groups face each other. One group faces another one group at a time, in a game based on true or false questions that involve subjects of applied biochemistry (exercise, obesity, diabetes, cholesterol, free radicals, among others. The questions of the Show are previously elaborated by senior students. The Biobio Show has four phases, the first one is a selection exam, and from the second to the fourth phase, eliminatory confrontations happen. On a confrontation, the first group must select a certain quantity of questions for the opponent to answer.  The group who choses the questions must know how to answer and justify the selected questions. This procedure is repeated on all phases of the show. On the last phase, the questions used are taken from an exam previously performed by the students: either the 9-hour biochemistry exam (Sé et al. A 9-hour biochemistry exam. An iron man competition or a good way of evaluating undergraduate students? SBBq 2005, abstract K-6 or the True-or-False exam (TFE (Sé et al. Are tutor-students capable of writing good biochemistry exams? SBBq 2004, abstract K-18. The winner group receives an extra 0,5 point on the final grade. Over 70% of the students informed on a questionnaire that the Biobio Show is a valuable tool for learning biochemistry.    That is a new way to enrich the discussion of biochemistry in the classroom without the students getting bored. Moreover, learning

Good breastfeeding policies -- good breastfeeding rates.

Science.gov (United States)

1998-01-01

In Norway, where breast-feeding policies protecting breast-feeding women's needs have been in place since the 1970s, approximately 97% of women breast feed when leaving the hospital, 80% are breast feeding at 3 months, and 20% beyond 12 months. Government family policies play an important role in enabling women to achieve good breast-feeding rates. In Norway: maternity leave is 42 weeks with full pay or 52 weeks with 80% of salary; flexible part-time is available for women from 2 months after giving birth with income supplemented from maternity benefits; after returning to work, women are entitled to 1- to 1.5-hour breaks to return home to breast feed, or to have the child brought to work. "Breast feeding is so normal," writes Hege Jacobson Lepri, "it's more embarrassing to bring out the feeding bottle in public." full text

Do good and poor readers make use of morphemic structure in English word recognition?

Directory of Open Access Journals (Sweden)

Lynne G. Duncan

2011-06-01

Full Text Available The links between oral morphological awareness and the use of derivational morphology are examined in the English word recognition of 8-year-old good and poor readers. Morphological awareness was assessed by a sentence completion task. The role of morphological structure in lexical access was examined by manipulating the presence of embedded words and suffixes in items presented for lexical decision. Good readers were more accurate in the morphological awareness task but did not show facilitation for real derivations even though morpho-semantic information appeared to inform their lexical decisions. The poor readers, who were less accurate, displayed a strong lexicality effect in lexical decision and the presence of an embedded word led to facilitation for words and inhibition for pseudo-words. Overall, the results suggest that both good and poor readers of English are sensitive to the internal structure of written words, with the better readers showing most evidence of morphological analysis.

12 CFR 747.7 - Good faith certification.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Good faith certification. 747.7 Section 747.7... of Practice and Procedure § 747.7 Good faith certification. (a) General requirement. Every filing or... good faith argument for the extension, modification, or reversal of existing law; and the filing or...

12 CFR 509.7 - Good faith certification.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Good faith certification. 509.7 Section 509.7... PROCEDURE IN ADJUDICATORY PROCEEDINGS Uniform Rules of Practice and Procedure § 509.7 Good faith... in fact and is warranted by existing law or a good faith argument for the extension, modification, or...

12 CFR 19.7 - Good faith certification.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Good faith certification. 19.7 Section 19.7... PROCEDURE Uniform Rules of Practice and Procedure § 19.7 Good faith certification. (a) General requirement... warranted by existing law or a good faith argument for the extension, modification, or reversal of existing...

Financial Giffen Goods

DEFF Research Database (Denmark)

Poulsen, Rolf; Rasmussen, Kourosh Marjani

2008-01-01

In the basic Markowitz and Merton models, a stock’s weight in efficient portfolios goes up if its expected rate of return goes up. Put differently, there are no financial Giffen goods. By an example from mortgage choice we illustrate that for more complicated portfolio problems Giffen effects do...

'The Good Citizen’

DEFF Research Database (Denmark)

Offersen, Sara Marie Hebsgaard; Vedsted, Peter; Andersen, Rikke Sand

2017-01-01

the Danish welfare state and the middle-class popula- tion is embodied in a responsibility for individual health. Overall, we identify a striving to be a ‘good citizen’; this entails confl icting moral possibilities in relation to experiencing, interpreting and acting on bodily sensations. We examine how...

Game design as marketing: How game mechanics create demand for virtual goods

Directory of Open Access Journals (Sweden)

Lehdonvirta, V.

2010-01-01

Full Text Available Selling virtual goods for real money is an increasingly popular revenue model for massively-multiplayer online games (MMOs, social networking sites (SNSs and other online hangouts. In this paper, we argue that the marketing of virtual goods currently falls short of what it could be. Game developers have long created compelling game designs, but having to market virtual goods to players is a relatively new situation to them. Professional marketers, on the other hand, tend to overlook the internal design of games and hangouts and focus on marketing the services as a whole. To begin bridging the gap, we propose that the design patterns and game mechanics commonly used in games and online hangouts should be viewed as a set of marketing techniques designed to sell virtual goods. Based on a review of a number of MMOs, we describe some of the most common patterns and game mechanics and show how their effects can be explained in terms of analogous techniques from marketing science. The results provide a new perspective to game design with interesting implications to developers. Moreover, they also suggest a radically new perspective to marketers of ordinary goods and services: viewing marketing as a form of game design.

Asymmetric public goods game cooperation through pest control.

Science.gov (United States)

Reeves, T; Ohtsuki, H; Fukui, S

2017-12-21

Cooperation in a public goods game has been studied extensively to find the conditions for sustaining the commons, yet the effect of asymmetry between agents has been explored very little. Here we study a game theoretic model of cooperation for pest control among farmers. In our simple model, each farmer has a paddy of the same size arranged adjacently on a line. A pest outbreak occurs at an abandoned paddy at one end of the line, directly threatening the frontier farmer adjacent to it. Each farmer pays a cost of his or her choice to an agricultural collective, and the total sum held by the collective is used for pest control, with success probability increasing with the sum. Because the farmers' incentives depend on their distance from the pest outbreak, our model is an asymmetric public goods game. We derive each farmer's cost strategy at the Nash equilibrium. We find that asymmetry among farmers leads to a few unexpected outcomes. The individual costs at the equilibrium do not necessarily increase with how much the future is valued but rather show threshold behavior. Moreover, an increase in the number of farmers can sometimes paradoxically undermine pest prevention. A comparison with a symmetric public goods game model reveals that the farmer at the greatest risk pays a disproportionate amount of cost in the asymmetric game, making the use of agricultural lands less sustainable. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

12 CFR 308.7 - Good faith certification.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Good faith certification. 308.7 Section 308.7... PRACTICE AND PROCEDURE Uniform Rules of Practice and Procedure § 308.7 Good faith certification. (a... in fact and is warranted by existing law or a good faith argument for the extension, modification, or...

12 CFR 263.7 - Good faith certification.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Good faith certification. 263.7 Section 263.7... RULES OF PRACTICE FOR HEARINGS Uniform Rules of Practice and Procedure § 263.7 Good faith certification... in fact and is warranted by existing law or a good faith argument for the extension, modification, or...

7 CFR 28.407 - Good Ordinary Color.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Good Ordinary Color. 28.407 Section 28.407 Agriculture..., TESTING, AND STANDARDS Standards Official Cotton Standards of the United States for the Color Grade of American Upland Cotton § 28.407 Good Ordinary Color. Good Ordinary Color is color which is within the range...

7 CFR 28.401 - Good Middling Color.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Good Middling Color. 28.401 Section 28.401 Agriculture..., TESTING, AND STANDARDS Standards Official Cotton Standards of the United States for the Color Grade of American Upland Cotton § 28.401 Good Middling Color. Good Middling Color is color which is within the range...

Rules for the certification of good practices in clinical laboratories. No regulation. 3-2009. Good Laboratory Practice

International Nuclear Information System (INIS)

2015-01-01

Regulation for Certification of Good Practices in clinical laboratories, hereinafter Regulation establishes the methodology and procedures for clinical laboratories to demonstrate their state of compliance with good practices, according to Regulation 3-2009, and that the CECMED can verify.

12 CFR 908.23 - Good faith certification.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Good faith certification. 908.23 Section 908.23... OPERATIONS RULES OF PRACTICE AND PROCEDURE IN HEARINGS ON THE RECORD General Rules § 908.23 Good faith... filing or submission of record is well-grounded in fact and is warranted by existing law or a good faith...

12 CFR 1780.7 - Good faith certification.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Good faith certification. 1780.7 Section 1780.7... DEVELOPMENT RULES OF PRACTICE AND PROCEDURE RULES OF PRACTICE AND PROCEDURE General Rules § 1780.7 Good faith... record is well-grounded in fact and is warranted by existing law or a good faith, nonfrivolous argument...

Good News for New Orleans: Early Evidence Shows Reforms Lifting Student Achievement

Science.gov (United States)

Harris, Douglas N.

2015-01-01

What happened to the New Orleans public schools following the tragic levee breeches after Hurricane Katrina is truly unprecedented. Within the span of one year, all public-school employees were fired, the teacher contract expired and was not replaced, and most attendance zones were eliminated. The state took control of almost all public schools…

Study on radioactivity in consumer goods

International Nuclear Information System (INIS)

1976-01-01

Consumer goods containing radionuclides are increasingly utilized, sometimes for having chemical or technological properties which nonradioactive materials cannot fulfill (e.g. uranium paints) or it may be that radioactivity is especially required (e.g. fluorescent paints, fire-alarm-boxes, electronic instruments). The present study makes a compilation of consumer goods containing radioactive substances which are available to the general public in the nine countries of the Community, carries out a medium and long term study to assess how accumulated radiation from these goods could affect the population as a whole, and proposes measures to minimize the effects of such accumulation

Let's Cancel the Dog-and-Pony Show

Science.gov (United States)

Marshall, Kim

2012-01-01

Why are so many educators willing to give credence to observations based on announced visits? Perhaps it's avoidance or a failure to distinguish between good teachers and good teaching, or perhaps it's the way the conventional teacher-evaluation model limits administrators' options. To put it bluntly, an evaluation process that relies on announced…

29 CFR 779.108 - Goods produced for commerce.

Science.gov (United States)

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Goods produced for commerce. 779.108 Section 779.108 Labor... Coverage Employees Engaged in Commerce Or in the Production of Goods for Commerce § 779.108 Goods produced for commerce. Goods are “produced for commerce” if they are “produced, manufactured, mined, handled or...

Counterfeit Goods and Income Inequality

OpenAIRE

Stefania Scandizzo

2001-01-01

This paper examines the effect of counterfeit goods in a world where consumers are differentiated by level of income and innovation is quality enhancing. Counterfeit goods are defined as products with the same characteristics as “originals”, but of lower quality. The effect of imitation on firms’ profits and consumer welfare depends on the distribution of income within the country. In particular, the greater the level of income inequality the larger the increase in consumer welfare due to the...

Good Policy, Good Practice II. Improving Outcomes and Productivity in Higher Education: A Guide for Policymakers

Science.gov (United States)

Brenneman, Meghan Wilson; Callan, Patrick M.; Ewell, Peter T.; Finney, Joni E.; Jones, Dennis P.; Zis, Stacey

2010-01-01

This new edition of "Good Policy, Good Practice II" revises and updates the authors' 2007 publication. Like the earlier edition, it responds to one of the questions that is raised most frequently in the authors' work with public policy and education leaders as they begin to address the national and state imperatives to increase the proportion of…

GOOD GOVERNANCE: NORMATIVE VS. DESCRIPTIVE DIMENSION

Directory of Open Access Journals (Sweden)

Ciprian IFTIMOAEI

2015-04-01

Full Text Available The concept of “good governance” was used for the first time in the 1989 World Bank Report – Sub-Saharan Africa: From Crisis to Sustainable Growth. A Long-Term Perspective Study – and has already made history in international studies, especially after the breakdown of the communist regimes. The governance has to do with authority, decision-making and accountability.The good governance is defined as the capacity of the government to manage a nation’s affaires, to provide economic development, welfare for citizens, and social protection for the poor. In this article,the concept of good governance is analysed according to two main dimensions: the normative dimension which comprises principles, values and norms that are guiding the international community and the governments in the management of policymaking process;the descriptive dimension which refers to the practical aspects of implementing the good governance’s standards as policies, programmes and structural reforms with the aim of solving or ameliorating the problems of developing countries.

Financing unemployment benefits by goods market competition: fiscal policy and deregulation with market imperfections

OpenAIRE

Antonio Scial…; Riccardo Tilli

2007-01-01

We consider a model in which the labor market is characterized by search frictions and there is monopolistic competition in the goods market. We introduce proportional income taxation and unemployment benefits with Government balanced budget constraint. Then, we evaluate the effects of both more competition in the goods market and higher unemployment benefits on labor market equilibrium and equilibrium tax rate. We show that more competition has a positive effect on equilibrium unemployment a...

Narrative Processes in Psychotherapy: differences between Good and Poor Outcome Clients

Directory of Open Access Journals (Sweden)

Luis Botella

2015-12-01

Full Text Available This paper compares 30 patients with good therapeutic outcome to 30 with poor therapeutic outcome in terms of the differential distribution of (1 Intake Variables (2 Outcome and Process Variables, and (3 Narrative Variables. Results indicated that psychosocial functioning, motivation, pre-therapy symptoms, Working Alliance, total number of therapy sessions, total pre-post symptom reduction, and mean scoring for total working alliance in sessions 3, 4, and 8 discriminated between both groups. Results also showed that almost all narrative variables except some of them discriminated good outcome clients from poor outcome ones from the beginning, midpoint and final stage of their therapeutic process. These results are discussed according to their relevance for clinical practice.

Introduction of an "energy goodness" number for supermarket

DEFF Research Database (Denmark)

Rasmussen, Bjarne D.; Munter, Preben; Holm, Henning V.

1999-01-01

A test method for determining the efficiency of supermarket refrigeration systems has been developed. The test method is based on a combination of measurements of air temperatures and energy consumption on an actual system and calculations of the energy consumption for a reference refrigeration...... between the calculated energy consumption of the reference system and the measured energy consumption for the actual system. Four different Danish supermarkets have been tested using this method. The results show that supermarkets in Denmark can be expected to have “Goodness numbers” ranging from 0...

Network public goods with asymmetric information about cooperation preferences and network degree

NARCIS (Netherlands)

Dijkstra, Jacob; van Assen, Marcus

2013-01-01

We propose a game theoretical model of one-shot network public goods formalizing the 'closure argument' that cooperation is more frequent in denser groups or networks. Equilibrium analyses show that (i) an 'inefficiency problem' exists: players all preferring mutual cooperation need not all

Towards good environmental governance in Europe

NARCIS (Netherlands)

Heldeweg, Michiel A.

2005-01-01

This article is about good governance, as presented in the 2001 EC White Paper, in relation to environmental legal policy making in Europe. First a concise analysis is made of the concept of good governance. Then, in a ``tour d’horizon’’, environmental policy programmes, legal cornerstones and

Good Faith in European Contract Law

NARCIS (Netherlands)

Hondius, E.H.

2002-01-01

Reinhard Zimmermann and Simon Whittaker, Good Faith in European Contract Law, pp 720, ISBN 0 521 77190 0, Cambridge University Press, Cambridge 2000. This is the first publication resulting from the Trento Common Core of European Private Law project. It analyses the law relating to good faith in

The ethics of big data as a public good: which public? Whose good?

Science.gov (United States)

Taylor, Linnet

2016-12-28

International development and humanitarian organizations are increasingly calling for digital data to be treated as a public good because of its value in supplementing scarce national statistics and informing interventions, including in emergencies. In response to this claim, a 'responsible data' movement has evolved to discuss guidelines and frameworks that will establish ethical principles for data sharing. However, this movement is not gaining traction with those who hold the highest-value data, particularly mobile network operators who are proving reluctant to make data collected in low- and middle-income countries accessible through intermediaries. This paper evaluates how the argument for 'data as a public good' fits with the corporate reality of big data, exploring existing models for data sharing. I draw on the idea of corporate data as an ecosystem involving often conflicting rights, duties and claims, in comparison to the utilitarian claim that data's humanitarian value makes it imperative to share them. I assess the power dynamics implied by the idea of data as a public good, and how differing incentives lead actors to adopt particular ethical positions with regard to the use of data.This article is part of the themed issue 'The ethical impact of data science'. © 2016 The Author(s).

Is Good Fit Related to Good Behaviour? Goodness of Fit between Daycare Teacher-Child Relationships, Temperament, and Prosocial Behaviour

Science.gov (United States)

Hipson, Will E.; Séguin, Daniel G.

2016-01-01

The Goodness-of-Fit model [Thomas, A., & Chess, S. (1977). Temperament and development. New York: Brunner/Mazel] proposes that a child's temperament interacts with the environment to influence child outcomes. In the past, researchers have shown how the association between the quality of the teacher-child relationship in daycare and child…

"The Corn People Have a Song Too. It Is Very Good": On Beauty, Truth, and Goodness

Science.gov (United States)

Chamberlin, J. Edward

2009-01-01

Twenty-first-century skeptics would say that there are really no such things as beauty and truth and certainly not goodness. A Pueblo poet seemed to think there was--"the corn people have a song / it is very good"--and unless people think they know better, they'd better listen up. This article begins with a short piece, set down by the…

On Becoming a Good English Language Learner: An Exploratory Case Study

Science.gov (United States)

Panzachi Heredia, Damaris Ana Ruth; Luchini, Pedro Luis

2015-01-01

This paper reports a case study that explores the cognitive process and the language learning strategies and styles that one Spanish trainee used to become a good English language learner. The participant held an in-depth, semi-structured interview and completed a learning style survey. Results show that the conscious use of multiple…

The psychological aspect of goods

Directory of Open Access Journals (Sweden)

Rejmaneh Evžen

2003-01-01

Full Text Available The author, a psychologist from Prague, discusses the theory of consumption from the socio-political angle. He discusses in detail the double features of goods from the psychological point of view: a the material features and b nominal, notional features of goods. The latter (nominal feature has been especially emphasized, the one that is being transformed into a specific "image of goods". The author also analyses its influence upon the consumers' behavior, connecting it with advertising as well. Later on in the paper the author shifts his analysis to the process of creating new products and to the establishment of the new conception that would not deal any more with individual products but rather with a "field of requirements". The author emphasizes the importance of research. He considers that changes in the way of living considerably influence the formation of requirements which in its turn asks for specific marketing methods in satisfying the requirements.

Note from the Goods Reception services

CERN Multimedia

FI Department

2008-01-01

Members of the personnel are invited to take note that only parcels corresponding to official orders or contracts will be handled at CERN. Individuals are not authorised to have private merchandise delivered to them at CERN and private deliveries will not be accepted by the Goods Reception services. Goods Reception Services

Exemplary Goods: Exemplars as Judgment Devices

NARCIS (Netherlands)

E. Dekker (Erwin)

2016-01-01

textabstractIn this article the notion of exemplars is developed to study valuation processes. It argues that exemplary goods are an important ‘judgment device’ on markets of singular goods, which has so far been ignored in the literature. The article draws on Hannah Arendt’s theory of exemplars, as

Basic model of quality and good practices in neonatal radiography

International Nuclear Information System (INIS)

Dias, Janine H.; Goulart, Juliana M.; Lykawka, Rochelle; Bacelar, Alexandre

2016-01-01

Neonatal chest radiographs were evaluated and 3 variables were analyzed: collimation, positioning and presence of artifacts. This study is a pilot for develop a model of good practices in radiology, which is in development phase. The index of analyzed radiographs considered inadequate is expressive and it shows the need for a model that may be part of an optimization program to medical exposures. (author)

Capuchin monkeys do not show human-like pricing effects

OpenAIRE

Catapano, Rhia; Buttrick, Nicholas; Widness, Jane; Goldstein, Robin; Santos, Laurie R.

2014-01-01

Recent work in judgment and decision-making has shown that a good's price can have irrational effects on people's preferences. People tend to prefer goods that cost more money and assume that such expensive goods will be more effective, even in cases where the price of the good is itself arbitrary. Although much work has documented the existence of these pricing effects, unfortunately little work has addressed where these price effects come from in the first place. Here we use a comparative a...

THE ATTITUDES TOWARD SPORT ADVERTISING AMONG THE QUESTION HOW OFTEN CONSUMERS PURCHASE SPORTING GOODS

Directory of Open Access Journals (Sweden)

Stevo Popović

2011-08-01

Full Text Available This research was aimed at gaining relevant knowledge about the attitudes toward sport advertising among the question how often consumers participate in sports activities The sample included 433 respondents, divided into six subsample groups: consumers who do not purchase sport goods at all, then consumers who purchase sport goods less than ones a month, next 1–3 a month, 4–6 a month, 7–9 a month, as well as consumers who purchase sport goods more than 10 times a months. The results of the measuring were analyzed by multivariate analysis (MANOVA and univariate analysis (ANOVA and Post Hoc test. Based on the results it was concluded that significant differences occur at multivariate level, as well as between all three variables at a significance level of p=.05. It is interesting to highlight that it was found that the significant differences showed up between the consumers who do not purchase sport goods at all with negative attitudes and consumers who purchase sport goods less than ones a months and more with positive attitudes toward sport advertising

Optimal Provision of Public Goods

DEFF Research Database (Denmark)

Kreiner, Claus Thustrup; Verdelin, Nicolaj

There currently exist two competing approaches in the literature on the optimal provision of public goods. The standard approach highlights the importance of distortionary taxation and distributional concerns. The new approach neutralizes distributional concerns by adjusting the non-linear income...... tax, and finds that this reinvigorates the simple Samuelson rule when preferences are separable in goods and leisure. We provide a synthesis by demonstrating that both approaches derive from the same basic formula. We further develop the new approach by deriving a general, intuitive formula...

Ductile Bulk Aluminum-Based Alloy with Good Glass-Forming Ability and High Strength

International Nuclear Information System (INIS)

Long-Chao, Zhuo; Shu-Jie, Pang; Hui, Wang; Tao, Zhang

2009-01-01

Based on a new approach for designing glassy alloy compositions, bulk Al-based alloys with good glass-forming ability (GFA) are synthesized. The cast Al 86 Si 0.5 Ni 4.06 Co 2.94 Y 6 Sc 0.5 rod with a diameter of 1 mm shows almost fully amorphous structure besides about 5% fcc-Al nucleated in the center of the rod. The bulk alloy with high Al concentration exhibits an ultrahigh yield strength of 1.18 GPa and maximum strength of 1.27 GPa as well as an obvious plastic strain of about 2.4% during compressive deformation. This light Al-based alloy with good GFA and mechanical properties is promising as a new high specific strength material with good deformability. (condensed matter: structure, mechanical and thermal properties)

ASSESSMENT OF GOOD PRACTICES IN HOSPITAL FOOD SERVICE BY COMPARING EVALUATION TOOLS.

Science.gov (United States)

Macedo Gonçalves, Juliana; Lameiro Rodrigues, Kelly; Santiago Almeida, Ângela Teresinha; Pereira, Giselda Maria; Duarte Buchweitz, Márcia Rúbia

2015-10-01

since food service in hospitals complements medical treatment, it should be produced in proper hygienic and sanitary conditions. It is a well-known fact that food-transmitted illnesses affect with greater severity hospitalized and immunosuppressed patients. good practices in hospital food service are evaluated by comparing assessment instruments. good practices were evaluated by a verification list following Resolution of Collegiate Directory n. 216 of the Brazilian Agency for Sanitary Vigilance. Interpretation of listed items followed parameters of RCD 216 and the Brazilian Association of Collective Meals Enterprises (BACME). Fisher's exact test was applied to detect whether there were statistically significant differences. Analysis of data grouping was undertaken with Unweighted Pair-group using Arithmetic Averages, coupled to a correlation study between dissimilarity matrixes to verify disagreement between the two methods. Good Practice was classified with mean total rates above 75% by the two methods. There were statistically significant differences between services and food evaluated by BACME instrument. Hospital Food Services have proved to show conditions of acceptable good practices. the comparison of interpretation tools based on RCD n. 216 and BACME provided similar results for the two classifications. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

Volunteering leads to rock-paper-scissors dynamics in a public goods game

Science.gov (United States)

Semmann, Dirk; Krambeck, Hans-Jürgen; Milinski, Manfred

2003-09-01

Collective efforts are a trademark of both insect and human societies. They are achieved through relatedness in the former and unknown mechanisms in the latter. The problem of achieving cooperation among non-kin has been described as the `tragedy of the commons', prophesying the inescapable collapse of many human enterprises. In public goods experiments, initial cooperation usually drops quickly to almost zero. It can be maintained by the opportunity to punish defectors or the need to maintain good reputation. Both schemes require that defectors are identified. Theorists propose that a simple but effective mechanism operates under full anonymity. With optional participation in the public goods game, `loners' (players who do not join the group), defectors and cooperators will coexist through rock-paper-scissors dynamics. Here we show experimentally that volunteering generates these dynamics in public goods games and that manipulating initial conditions can produce each predicted direction. If, by manipulating displayed decisions, it is pretended that defectors have the highest frequency, loners soon become most frequent, as do cooperators after loners and defectors after cooperators. On average, cooperation is perpetuated at a substantial level.

Evolution of Cooperation in Public Goods Games

International Nuclear Information System (INIS)

Xia Chengyi; Zhang Juanjuan; Wang Jinsong; Wang Yiling

2011-01-01

We investigate the evolution of cooperation with evolutionary public goods games based on finite populations, where four pure strategies: cooperators, defectors, punishers and loners who are unwilling to participate are considered. By adopting approximate best response dynamics, we show that the magnitude of rationality not only quantitatively explains the experiment results in [Nature (London) 425 (2003) 390], but also it will heavily influence the evolution of cooperation. Compared with previous results of infinite populations, which result in two equilibriums, we show that there merely exists a special equilibrium and the relevant high value of bounded rationality will sustain cooperation. In addition, we characterize that loner's payoff plays an active role in the maintenance of cooperation, which will only be warranted for the low and moderate values of loner's payoff. It thus indicates the effects of rationality and loner's payoff will influence the cooperation. Finally, we highlight the important result that the introduction of voluntary participation and punishment will facilitate cooperation greatly. (general)

Statistical alignment: computational properties, homology testing and goodness-of-fit

DEFF Research Database (Denmark)

Hein, J; Wiuf, Carsten; Møller, Martin

2000-01-01

The model of insertions and deletions in biological sequences, first formulated by Thorne, Kishino, and Felsenstein in 1991 (the TKF91 model), provides a basis for performing alignment within a statistical framework. Here we investigate this model.Firstly, we show how to accelerate the statistical...... alignment algorithms several orders of magnitude. The main innovations are to confine likelihood calculations to a band close to the similarity based alignment, to get good initial guesses of the evolutionary parameters and to apply an efficient numerical optimisation algorithm for finding the maximum...... analysis.Secondly, we propose a new homology test based on this model, where homology means that an ancestor to a sequence pair can be found finitely far back in time. This test has statistical advantages relative to the traditional shuffle test for proteins.Finally, we describe a goodness-of-fit test...

Men behaving nicely: public goods as peacock tails.

Science.gov (United States)

Van Vugt, Mark; Iredale, Wendy

2013-02-01

Insights from sexual selection and costly signalling theory suggest that competition for females underlies men's public good contributions. We conducted two public good experiments to test this hypothesis. First, we found that men contributed more in the presence of an opposite sex audience, but there was no parallel effect for the women. In addition, men's public good contributions went up as they rated the female observer more attractive. In the second experiment, all male groups played a five round public good game and their contributions significantly increased over time with a female audience only. In this condition men also volunteered more time for various charitable causes. These findings support the idea that men compete with each other by creating public goods to impress women. Thus, a public good is the human equivalent of a peacock's tail. © 2012 The British Psychological Society.

Ideas and Inspirations: Good News about Diabetes Prevention and Management in Indian Country

Medline Plus

Full Text Available ... selected presentation recordings. Good news: Reduction in Kidney Failure in AI/AN People Exit Disclaimer: You Are ... ihs.gov showing a dramatic decrease in kidney failure from diabetes among American Indians and Alaska Natives. ...

Luggage and shipped goods

International Nuclear Information System (INIS)

Vogel, H.; Haller, D.

2007-01-01

Summary: Purpose: Control of luggage and shipped goods are frequently carried out. The possibilities of X-ray technology shall be demonstrated. Materials and methods: There are different imaging techniques. The main concepts are transmission imaging, backscatter imaging, computed tomography, and dual energy imaging and the combination of different methods The images come from manufacturers and personal collections. Results: The search concerns mainly, weapons, explosives, and drugs; furthermore animals, and stolen goods, Special problems offer the control of letters and the detection of Improvised Explosive Devices (IED). Conclusion: One has to expect that controls will increase and that imaging with X-rays will have their part. Pattern recognition software will be used for analysis enforced by economy and by demand for higher efficiency - man and computer will produce more security than man alone

Anti-piracy policy and quality differential in markets for information goods

OpenAIRE

Francisco Martínez-Sánchez; Javier M. López Cuñat

2011-01-01

In this paper we analyze the strategic decisions of the government, the incumbent and the pirate in a market where the good is piratable. We show that deterred or accommodated piracy can occur in equilibrium, but pure monopoly cannot occur for any anti-piracy policy. We also show that the initial quality differential between the original and the pirated product is essential to explain the effects of an increase in the quality of pirated product on both the level of piracy and the optimal moni...

Capuchin monkeys do not show human-like pricing effects

Science.gov (United States)

Catapano, Rhia; Buttrick, Nicholas; Widness, Jane; Goldstein, Robin; Santos, Laurie R.

2014-01-01

Recent work in judgment and decision-making has shown that a good's price can have irrational effects on people's preferences. People tend to prefer goods that cost more money and assume that such expensive goods will be more effective, even in cases where the price of the good is itself arbitrary. Although much work has documented the existence of these pricing effects, unfortunately little work has addressed where these price effects come from in the first place. Here we use a comparative approach to distinguish between different accounts of this bias and to explore the origins of these effects. Specifically, we test whether brown capuchin monkeys (Cebus apella) are also susceptible to pricing effects within the context of an experimentally trained token economy. Using a capuchin population previously trained in a token market, we explored whether monkeys used price as an indicator of value across four experiments. Although monkeys demonstrated an understanding of which goods had which prices (consistently shifting preferences to cheaper goods when prices were increased), we observed no evidence that such price information affected their valuation of different kinds of goods. These results suggest that human pricing effects may involve more sophisticated human-unique cognitive capacities, such as an understanding of market forces and signaling. PMID:25520677

Capuchin monkeys do not show human-like pricing effects.

Science.gov (United States)

Catapano, Rhia; Buttrick, Nicholas; Widness, Jane; Goldstein, Robin; Santos, Laurie R

2014-01-01

Recent work in judgment and decision-making has shown that a good's price can have irrational effects on people's preferences. People tend to prefer goods that cost more money and assume that such expensive goods will be more effective, even in cases where the price of the good is itself arbitrary. Although much work has documented the existence of these pricing effects, unfortunately little work has addressed where these price effects come from in the first place. Here we use a comparative approach to distinguish between different accounts of this bias and to explore the origins of these effects. Specifically, we test whether brown capuchin monkeys (Cebus apella) are also susceptible to pricing effects within the context of an experimentally trained token economy. Using a capuchin population previously trained in a token market, we explored whether monkeys used price as an indicator of value across four experiments. Although monkeys demonstrated an understanding of which goods had which prices (consistently shifting preferences to cheaper goods when prices were increased), we observed no evidence that such price information affected their valuation of different kinds of goods. These results suggest that human pricing effects may involve more sophisticated human-unique cognitive capacities, such as an understanding of market forces and signaling.

USSR Report: Consumer Goods and Domestic Trade

National Research Council Canada - National Science Library

1985-01-01

.... This document contains articles on consumer goods and domestic trade within the USSR. Topics include: consumer goods production and distribution, housing and personal services, and consumer sector policy and economics.

Good is not good enough: the culture of low expectations and the leader's challenge.

Science.gov (United States)

Kerfoot, Karlene M

2009-01-01

When people believe that what they do is "good enough," excellence will never occur. As the demand for better health care escalates every year, achieving a ranking of very good doesn't count because it leaves many disenfranchised staff, errors, and dissatisfied patients. A leader can not be successful unless the culture of low expectations is eliminated. If there isn't a sense of caring, serving, and being an exemplar of the change, the leader won't succeed in moving the culture. When there is a sense of ownership and commitment to the mission and to patients, the culture of low expectations cannot exist.

Punishment Mechanism with Self-Adjusting Rules in Spatial Voluntary Public Goods Games

Science.gov (United States)

Wu, Zhong-Wei; Xu, Zhao-Jin; Zhang, Lian-Zhong

2014-11-01

The phenomena of cooperation in animal and human society are ubiquitous, but the selfish outcome that no player contributes to the public good will lead to the “tragedy of the commons”. The recent research shows that high punishment can improve the cooperation of the population. In this paper, we introduce a punishment mechanism into spatial voluntary public goods games with every individual only knowing his own payoff in each round. Using the self-adjusting rules, we find that the different cost for punishment can lead to different effects on the voluntary public goods games. Especially, when the cost for punishment is decreased, a higher contribution region will appear in the case of low r value. It means even for the low r value, individuals can form the contributing groups in large quantities to produce a more efficient outcome than that in moderate r value. In addition, we also find the players' memory can have effects on the average outcome of the population.

Designer genes. Recombinant antibody fragments for biological imaging

Energy Technology Data Exchange (ETDEWEB)

Wu, A.M.; Yazaki, P.J. [Beckman Research Institute of the City of Hope, Duarte, CA (United States). Dept. of Molecular Biology

2000-09-01

Monoclonal antibodies (MAbs), with high specificity and high affinity for their target antigens, can be utilized for delivery of agents such as radionuclides, enzymes, drugs or toxins in vivo. However, the implementation of radiolabeled antibodies as magic bullets for detection and treatment of diseases such as cancer has required addressing several shortcomings of murine MAbs. These include their immunogenicity, sub-optimal targeting and pharmacokinetic properties, and practical issues of production and radiolabeling. Genetic engineering provides a powerful approach for redesigning antibodies for use in oncologic applications in vivo. Recombinant fragments have been produced that retain high affinity for target antigens, and display a combination of rapid, high-level tumor targeting with concomitant clearance from normal tissues and the circulation in animal models. An important first step was cloning and engineering of antibody heavy and light chain variable domains into single-chain Fvs (molecular weight, 25-17 kDa), in which the variable regions are joined via a synthetic linker peptide sequence. Although scFvs themselves showed limited tumor uptake in preclinical and clinical studies, they provide a useful building block for intermediate sized recombinant fragments. Covalently linked dimers or non-covalent dimers of scFvs (also known as diabodies) show improved targeting and clearance properties due to their higher molecular weight (55kDa) and increased avidity. Further gains can be made by generation of larger recombinant fragments, such as the minibody, an scFv-C{sub H}3 fusion protein that self-assembles into a bivalent dimer of 80 kDa. A systematic evaluation of scFv, diabody, minibody, and intact antibody (based on comparison of tumor uptakes, tumor: blood activity ratios, and calculation of an Imaging Figure of Merit) can form the basis for selection of combinations of recombinant fragments and radionuclides for imaging applications. Ease of engineering

Designer genes. Recombinant antibody fragments for biological imaging

International Nuclear Information System (INIS)

Wu, A.M.; Yazaki, P.J.

2000-01-01

Monoclonal antibodies (MAbs), with high specificy and high affinity for their target antigens, can be utilized for delivery of agents such as radionuclides, enzymes, drugs or toxins in vivo. However, the implementation of radiolabeled antibodies as magic bullets for detection and treatment of diseases such as cancer has required addressing several shortcomings of murine MAbs. These include their immunogenicity, sub-optimal targeting and pharmacokinetic properties, and practical issues of production and radiolabeling. Genetic engineering provides a powerful approach for redesigning antibodies for use in oncologic applications in vivo. Recombinant fragments have been produced that retain high affinity for target antigens, and display a combination of rapid, high-level tumor targeting with concomitant clearance from normal tissues and the circulation in animal models. An important first step was cloning and engineering of antibody heavy and light chain variable domains into single-chain Fvs (molecular weight, 25-17 kDa), in which the variable regions are joined via a synthetic linker peptide sequence. Although scFvs themselves showed limited tumor uptake in preclinical and clinical studies, they provide a useful building block for intermediate sized recombinant fragments. Covalently linked dimers or non-covalent dimers of scFvs (also known as diabodies) show improved targeting and clearance properties due to their higher molecular weight (55kDa) and increased avidity. Further gains can be made by generation of larger recombinant fragments, such as the minibody, an scFv-C H 3 fusion protein that self-assembles into a bivalent dimer of 80 kDa. A systematic evaluation of scFv, diabody, minibody, and intact antibody (based on comparison of tumor uptakes, tumor: blood activity ratios, and calculation of an Imaging Figure of Merit) can form the basis for selection of combinations of recombinant fragments and radionuclides for imaging applications. Ease of engineering and

Ideas and Inspirations: Good News about Diabetes Prevention and Management in Indian Country

Medline Plus

Full Text Available ... watch selected presentation recordings. Good news: Reduction in Kidney Failure in AI/AN People Exit Disclaimer: You Are ... www.ihs.gov showing a dramatic decrease in kidney failure from diabetes among American Indians and Alaska Natives. ...

Doing good parenthood as we-ness

DEFF Research Database (Denmark)

Westerling, Allan; Sparrman, Anna

This paper reflects on how good parenthood is done through ‘we-ness’. We draw on empirical work published by Danish and Swedish researchers to argue that we-ness constitutes an ideal in contemporary family life. In our recent edited volume Doing good parenthood, we argue that the term parenthood...... and family life. With this paper, we explore and discuss the concepts of we-ness, childhood and parenthood further, foremost by analyzing how ideals of equality are translated into the everyday practices of doing we-ness and family life. How and by whom is we-ness established and are there intensive...... and light versions of we-ness? How can we understand the relation between we-ness and goodness in parenthood?...

21 CFR 110.5 - Current good manufacturing practice.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Current good manufacturing practice. 110.5 Section...) FOOD FOR HUMAN CONSUMPTION CURRENT GOOD MANUFACTURING PRACTICE IN MANUFACTURING, PACKING, OR HOLDING HUMAN FOOD General Provisions § 110.5 Current good manufacturing practice. (a) The criteria and...

The world trade organisation and Human Rights: The role of principles of Good Governance

Directory of Open Access Journals (Sweden)

J Denkers

2008-08-01

Full Text Available The present article attempts to determine the role of principles of good governance in the discussion regarding the World Trade Organisation (WTO and its human rights accountability. It shows that the WTO as an organisation cannot be compared to other international organisations that are more autonomous such as the International Monetary Fund (IMF or the World Bank. This does not mean, however, that the WTO has no autonomous powers at all. This contribution attempts to make clear what these activities are and how they may affect the protection of human rights. The implementation of good governance principles in international organisations can be considered a sine qua non for the realisation of human rights. Therefore, it will be examined what role the principles of good governance plays within the WTO. More specifically, the focus will be on how the good governance principles of transparency and participation can contribute to sensitising the organisation for human rights considerations.

Quantifying capital goods for waste incineration

International Nuclear Information System (INIS)

Brogaard, L.K.; Riber, C.; Christensen, T.H.

2013-01-01

Highlights: • Materials and energy used for the construction of waste incinerators were quantified. • The data was collected from five incineration plants in Scandinavia. • Included were six main materials, electronic systems, cables and all transportation. • The capital goods contributed 2–3% compared to the direct emissions impact on GW. - Abstract: Materials and energy used for the construction of modern waste incineration plants were quantified. The data was collected from five incineration plants (72,000–240,000 tonnes per year) built in Scandinavia (Norway, Finland and Denmark) between 2006 and 2012. Concrete for the buildings was the main material used amounting to 19,000–26,000 tonnes per plant. The quantification further included six main materials, electronic systems, cables and all transportation. The energy used for the actual on-site construction of the incinerators was in the range 4000–5000 MW h. In terms of the environmental burden of producing the materials used in the construction, steel for the building and the machinery contributed the most. The material and energy used for the construction corresponded to the emission of 7–14 kg CO 2 per tonne of waste combusted throughout the lifetime of the incineration plant. The assessment showed that, compared to data reported in the literature on direct emissions from the operation of incinerators, the environmental impacts caused by the construction of buildings and machinery (capital goods) could amount to 2–3% with respect to kg CO 2 per tonne of waste combusted

How Good Is Multi-Pivot Quicksort?

DEFF Research Database (Denmark)

Aumüller, Martin; Dietzfelbinger, Martin; Klaue, Pascal

2016-01-01

of the partitioning cost is caused by rearranging elements. A rigorous analysis of an algorithm for rearranging elements in the partitioning step is carried out, observing mainly how often array cells are accessed during partitioning. The algorithm behaves best if three to five pivots are used. Experiments show...... that this translates into good cache behavior and is closest to predicting observed running times of multi-pivot quicksort algorithms. Finally, it is studied how choosing pivots from a sample affects sorting cost. The study is theoretical in the sense that although the findings motivate design recommendations...... as the standard sorting algorithm in Sun’s Java 7. In 2014 at ALENEX, Kushagra et al. introduced an even faster algorithm that uses three pivots. This article studies what possible advantages multi-pivot quicksort might offer in general. The contributions are as follows: Natural comparison-optimal algorithms...

49 CFR 218.97 - Good faith challenge procedures.

Science.gov (United States)

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Good faith challenge procedures. 218.97 Section... Derails § 218.97 Good faith challenge procedures. (a) Employee responsibility. An employee shall inform the railroad or employer whenever the employee makes a good faith determination that the employee has...

The Determinants of FTSE4 Good Bursa Malaysia

Directory of Open Access Journals (Sweden)

Abu Nor ‘Asyiqin

2017-01-01

Full Text Available This study was conducted to identify the factors that influence the companies listed in Bursa Malaysia to be indexed as FTSE4Good Bursa Malaysia (F4GBM. The companies awarded as F4GBM are those with good sustainable practices. This study investigates the potential factors that explain the good sustainable practice (i.e. corporate size, financial performance, industry attachment and sharia-compliant. Analysis reveals that only corporate size which proxy by market capitalization has significant relationship with good sustainable practice.

The role of public goods in planetary evolution

Science.gov (United States)

McInerney, James O.; Erwin, Douglas H.

2017-11-01

Biological public goods are broadly shared within an ecosystem and readily available. They appear to be widespread and may have played important roles in the history of life on Earth. Of particular importance to events in the early history of life are the roles of public goods in the merging of genomes, protein domains and even cells. We suggest that public goods facilitated the origin of the eukaryotic cell, a classic major evolutionary transition. The recognition of genomic public goods challenges advocates of a direct graph view of phylogeny, and those who deny that any useful phylogenetic signal persists in modern genomes. Ecological spillovers generate public goods that provide new ecological opportunities. This article is part of the themed issue 'Reconceptualizing the origins of life'.

47 CFR 73.24 - Broadcast facilities; showing required.

Science.gov (United States)

2010-10-01

... requirements of good engineering practice. (f) That the facilities sought are subject to assignment as... proposed assignment will tend to effect a fair, efficient, and equitable distribution of radio service... corporation or other organization) is of good character and possesses other qualifications sufficient to...

7 CFR 28.411 - Good Middling Light Spotted Color.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Good Middling Light Spotted Color. 28.411 Section 28... Light Spotted Color. Good Middling Light Spotted Color is color which in spot or color, or both, is between Good Middling Color and Good Middling Spotted Color. ...

A simple test for PPP among traded goods

NARCIS (Netherlands)

Ph.H.B.F. Franses (Philip Hans); D.J.C. van Dijk (Dick)

2002-01-01

textabstractThe so-called Balassa-Samuelson model implies that relative prices of non-traded goods may be nonstationary and, hence, that PPP should preferably be tested on real exchange rates based on prices of traded goods only. We propose a simple test for PPP among traded goods which can be

21 CFR 225.1 - Current good manufacturing practice.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Current good manufacturing practice. 225.1 Section...) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS General Provisions § 225.1 Current good manufacturing practice. (a) Section 501(a)(2)(B) of the Federal Food, Drug, and Cosmetic Act...

21 CFR 226.1 - Current good manufacturing practice.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Current good manufacturing practice. 226.1 Section...) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR TYPE A MEDICATED ARTICLES General Provisions § 226.1 Current good manufacturing practice. (a) The criteria in §§ 226.10 through 226.115, inclusive...

Nondestructive analysis for the study of cultural goods

International Nuclear Information System (INIS)

Obrutsky, Alba E.

2009-01-01

The experience obtained by the laboratories of CNEA in the study of cultural goods, particularly of archaeological, historical and artistic goods, required the development of specific methodologies as they are unique and irreplaceable. When a goods is defined as 'cultural heritage' it has to be studied to verify special features that can not be observed at plain sight, then the application of Non Destructive Assays Method is a useful tool for evaluation, determination of conservation conditions, verification of possible restorations, and to elaborate a general diagnosis of the inspected goods. (author) [es

Searching for the objective good faith in contract law

OpenAIRE

IKONOMI ERGYSA

2016-01-01

: Referring to a classical division of contractual good faith, in order to realize a full study, there are distinguished two senses of it: (1) subjective good faith and (2) objective good faith. The paper is realized as an overview of good faith in the objective sense, analyzing different legal provisions of some contractual laws. This paper aims to explain the meaning, characteristics, role and the application of objective good faith and to find and explain the differences between subjective...

The Market's Place in the Provision of Goods

NARCIS (Netherlands)

Claassen, R.J.G.

2008-01-01

Which goods should we be able to buy and sell on the market and, alternatively, which goods should remain sheltered from the market? For many goods in modern societies, this has proven to be a thorny question. Moreover, it is a question that cannot be answered by way of a theoretical shortcut, that

The Doha Negotiations on Trade in Goods: An European Perspective

OpenAIRE

Messerlin , Patrick

2006-01-01

The note reviews the basic market access issues in the Doha negotiations on trade in goods from an European perspective. First, it shows that some European negotiators are demanding more concessions in manufacturing (NAMA) that the European business community is asking for - adding strong tensions in a context already marked by severe problems in farm talks. Second, the note reveals the European interests really at stake in the agricultural negotiations, before addressing the negotiating issu...

Food for thought: pretty good multispecies yield

DEFF Research Database (Denmark)

Rindorf, Anna; Dichmont, C. M.; Levin, P.S.

2017-01-01

good multidimensional yield to accommodate situations where the yield from a stock affects the ecosystem, economic and social benefits, or sustainability. We demonstrate in a European example that PGMY is a practical concept. As PGMY provides a safe operating space for management that adheres...... that broader ecosystem, economic, and social objectives are addressed. We investigate how the principles of a “pretty good yield” range of fishing mortalities assumed to provide >95% of the average yield for a single stock can be expanded to a pretty good multispecies yield (PGMY) space and further to pretty...

Ecology and the Good

Science.gov (United States)

Gustafson, James W.

1971-01-01

Our value system relating to the natural sciences is examined for its acceptability and worthiness. Scrutinized are the cognitive meanings about values, validity of values, subjective and cultural relativism, the good of objective realities, and cooperation with natural forces and God. (BL)

How to give a good talk.

Science.gov (United States)

Alon, Uri

2009-10-23

We depend on talks to communicate our work, and we spend much of our time as audience members in talks. However, few scientists are taught the well-established principles of giving good talks. Here, I describe how to prepare, present, and answer questions in a scientific talk. We will see how a talk prepared with a single premise and delivered with good eye contact is clear and enjoyable.

Mechanism of Action of Botulinum Neurotoxin and Overview of Medical Countermeasures for Intoxication

Science.gov (United States)

2008-01-01

techni-cally feasible. As a further refinement, a yeast display system was used as a technology platform for performingmolecular evolution by increasing...the affinity of those scFv antibodies that bind to BoNT/ A. Yeast -displayed scFv libraries have been constructed by selecting scFvs that bind with...hazelnut yoghurt. Epidemiol. Infect. 104:389-395. Oost, T., Sukonpan, C., Brewer , M., Goodnough, M., Tepp, W., Johnson, E.A, and Rich, D.H. 2003. Design

An efficient method for isolating antibody fragments against small peptides by antibody phage display

DEFF Research Database (Denmark)

Duan, Zhi; Siegumfeldt, Henrik

2010-01-01

We generated monoclonal scFv (single chain variable fragment) antibodies from an antibody phage display library towards three small synthetic peptides derived from the sequence of s1-casein. Key difficulties for selection of scFv-phages against small peptides were addressed. Small peptides do....... The scFvs were sequenced and characterized, and specificity was characterized by ELISA. The methods developed in this study are universally applicable for antibody phage display to efficiently produce antibody fragments against small peptides....

Transport and handling of dangerous goods. Training of persons in charge of vehicles or vessels carrying dangerous goods by road or by inland waterways (Dangerous Goods 1979 No.1)

International Nuclear Information System (INIS)

1979-01-01

This Order supplements the Regulations of 15 April 1945 on the transport of dangerous goods by rail, land and inland waterways. It deals with the training of persons in charge of vehicles or boats carrying dangerous goods by road or by inland waterways. It refers in particular to transport of radioactive materials. (NEA) [fr

PENERAPAN PRINSIP-PRINSIP GOOD GOVERNANCE DALAM PELAYANAN PUBLIK DI KANTOR CAMAT SAIL KOTA PEKANBARU

Directory of Open Access Journals (Sweden)

Sri Roserdevi Nasution

2018-02-01

Full Text Available Good Governance is the new face of hearts implement the principles of Public Service in the reform era. Public services Law No. 25 of 2009 is activities or circuit hearts Frame activities Fulfillment Services Under legislation with every citizen Share And Population differences Goods, services, and administrative services or Provided By Operation of Public Service. Public services carried out by the Government showed to society who asked service. Research Type singer is descriptive qualitative approach with, the techniques data collection using depth Interviews and Documentation. Results of Research Singer nearly all the principles of good governance hearts Services Not Running In accordance with From UNDP as Principles of Participation, legal rules, Transparency, Responsiveness, consensus-oriented, fairness, effectiveness, accountability, and strategic vision, Many Are Being inhibit the progress of the Principles of good governance. The conclusion from the findings of research, so authors concluded that the application of good governance in the hearts Implementation Services Head Office Sail Maximum yet. It is because that the singer Leadership And yet the implementation of communication subordinate ones in line so that although Head Already Trying to give the Best but if NOT in Support By subordinates will Difficult accomplished. Lack of human resources is a prayer One That Become an inhibiting factor hearts implementation of the Principles of good governance in the future Head Office Sail.

7 CFR 28.406 - Strict Good Ordinary Color.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Strict Good Ordinary Color. 28.406 Section 28.406... for the Color Grade of American Upland Cotton § 28.406 Strict Good Ordinary Color. Strict Good Ordinary Color is color which is within the range represented by a set of samples in the custody of the...

Research on Effective Supply Mode of Rural Public Goods

Institute of Scientific and Technical Information of China (English)

2011-01-01

On the basis of definition and classification of rural public goods, this paper analyses the status quo of public goods supply in vast rural areas of China, and it indicates that the electricity and communication facility in rural areas have not yet been popularized; the culture and education facility is critically backward; the medical care and social warfare institutions are short. It points out the rational supply model of public goods as follows: the government plays dominant role in the public goods supply with a large amount of investments, related to the quality of living and production of multitudinous farmers; small wieldy quasi-public goods that can be easily supplied and marginalized public goods can introduce multiplex supply main body under the framework of government guidance. According to this model, corresponding policy suggestions are put forward as follows: increase financial inputs, and perfect local financial system; actively encourage the majority of farmers in rural areas to participate in public goods supply mechanism, so that the supply has pertinence; vigorously develop multiplex supply system of rural public goods, to ensure effective supply.

Verifiable Distribution of Material Goods Based on Cryptology

Directory of Open Access Journals (Sweden)

Radomír Palovský

2015-12-01

Full Text Available Counterfeiting of material goods is a general problem. In this paper an architecture for verifiable distribution of material goods is presented. This distribution is based on printing such a QR code on goods, which would contain digitally signed serial number of the product, and validity of this digital signature could be verifiable by a customer. Extension consisting of adding digital signatures to revenue stamps used for state-controlled goods is also presented. Discussion on possibilities in making copies leads to conclusion that cryptographic security needs to be completed by technical difficulties of copying.

Polymer models with optimal good-solvent behavior

Science.gov (United States)

D'Adamo, Giuseppe; Pelissetto, Andrea

2017-11-01

We consider three different continuum polymer models, which all depend on a tunable parameter r that determines the strength of the excluded-volume interactions. In the first model, chains are obtained by concatenating hard spherocylinders of height b and diameter rb (we call them thick self-avoiding chains). The other two models are generalizations of the tangent hard-sphere and of the Kremer-Grest models. We show that for a specific value r* , all models show optimal behavior: asymptotic long-chain behavior is observed for relatively short chains. For r < r* , instead, the behavior can be parametrized by using the two-parameter model, which also describes the thermal crossover close to the θ point. The bonds of the thick self-avoiding chains cannot cross each other, and therefore the model is suited for the investigation of topological properties and for dynamical studies. Such a model also provides a coarse-grained description of double-stranded DNA, so that we can use our results to discuss under which conditions DNA can be considered as a model good-solvent polymer.

Is Social Capital a Good Concept?

DEFF Research Database (Denmark)

Bjørnskov, Christian; Sønderskov, Kim Mannemar

2013-01-01

This paper explores whether the concept of social capital as popularized by Robert Putnam is a good social science concept. Taking Gerring’s work on concept evaluation as the starting point, the paper first presents a set of criteria for conceptual ‘goodness’ and discusses how social capital...... performs on these criteria. It is argued that social capital eventually may be a good concept if it can be shown empirically to be a unidimensional concept. An empirical section therefore explores the validity of the unidimensionality assumption and rejects it in four separate tests at both the individual...... and aggregate level. We conclude that even if social capital has been a remarkably productive idea, it is not a good concept as most popular conceptualizations define social capital as several distinct phenomena or as phenomena that already have been conceptualized under other labels....

Capuchin monkeys do not show human-like pricing effects

Directory of Open Access Journals (Sweden)

Rhia eCatapano

2014-12-01

Full Text Available Recent work in judgment and decision-making has shown that a good’s price can have irrational effects on people’s preferences. People tend to prefer goods that cost more money and assume that such expensive goods will be more effective, even in cases where the price of the good is itself arbitrary. Although much work has documented the existence of these pricing effects, unfortunately little work has addressed where these price effects come from in the first place. Here we use a comparative approach to distinguish between different accounts of this bias and to explore the origins of these effects. Specifically, we test whether brown capuchin monkeys (Cebus apella are also susceptible to pricing effects within the context of an experimentally trained token economy. Using a capuchin population previously trained in a token market, we explored whether monkeys used price as an indicator of value across four experiments. Although monkeys demonstrated an understanding of which goods had which prices (consistently shifting preferences to cheaper goods when prices were increased, we observed no evidence that such price information affected their valuation of different kinds of goods. These results suggest that human price effects may involve more sophisticated human-unique cognitive capacities, such as an understanding of market forces and signaling.

Turning a Poor Ion Channel into a Good Pump

Science.gov (United States)

Astumian, Dean

2003-05-01

We consider a membrane protein that can exist in two configurations, either one of which acts as a poor ion channel, allowing ions to slowly leak across the membrane from high to low elctrochemical potential. We show that random external fluctuations can provide the energy to turn this poor channel into a good pump that drives ion transport from low to high electrochemical potential. We discuss this result in terms of a gambling analogy, and point to possible implications for fields as far ranging as population biology, economics, and actuarial science.

29 CFR 790.15 - “Good faith.”

Science.gov (United States)

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false âGood faith.â 790.15 Section 790.15 Labor Regulations... OF 1947 ON THE FAIR LABOR STANDARDS ACT OF 1938 Defense of Good Faith Reliance on Administrative Regulations, Etc. § 790.15 “Good faith.” (a) One of the most important requirements of sections 9 and 10 is...

Is Globalization Good for the Poor? A Reply to Pogge

DEFF Research Database (Denmark)

Sønderholm, Jørn; Lydholm, Henrik

2016-01-01

an economic polarization between the wealthiest and poorest people of the world, is not, we contend, something that in itself offers strong support for his view that the global institutional order is a significant cause of this economic polarization. We believe that Pogge overemphasizes the impact......In an article from 2011, Thomas Pogge asks if globalization is good for the world’s poor. Pogge answers in the negative. As important evidence for the view that the globalization period has not been good for the world’s poor, Pogge cites a dataset provided by Branko Milanović (CUNY......). In this article, we do not take issue with Pogge’s definition of “globalization”, “the world’s poor” or with the veracity of the empirical data he refers to in articulating and defending his view about globalization and the world’s poor. However, Pogge’s reference to a dataset showing that there has been...

How Good Is Good: Improved Tracking and Managing of Safety Goals, Performance Indicators, Production Targets and Significant Events Using Learning Curves

International Nuclear Information System (INIS)

Duffey, Rommey B.; Saull, John W.

2002-01-01

We show a new way to track and measure safety and performance using learning curves derived on a mathematical basis. When unusual or abnormal events occur in plants and equipment, the regulator and good management practice requires they be reported, investigated, understood and rectified. In addition to reporting so-called 'significant events', both management and the regulator often set targets for individual and collective performance, which are used for both reward and criticism. For almost completely safe systems, like nuclear power plants, commercial aircraft and chemical facilities, many parameters are tracked and measured. Continuous improvement has to be demonstrated, as well as meeting reduced occurrence rates, which are set as management goals or targets. This process usually takes the form of statistics for availability of plant and equipment, forced or unplanned maintenance outage, loss of safety function, safety or procedural violations, etc. These are often rolled up into a set of so-called 'Performance Indicators' as measures of how well safety and operation is being managed at a given facility. The overall operating standards of an industry are also measured. A whole discipline is formed of tracking, measuring, reporting, managing and understanding the plethora of indicators and data. Decreasing occurrence rates and meeting or exceeding goals are seen and rewarded as virtues. Managers and operators need to know how good is their safety management system that has been adopted and used (and paid for), and whether it can itself be improved. We show the importance of accumulated experience in correctly measuring and tracking the decreasing event and error rates speculating a finite minimum rate. We show that the rate of improvement constitutes a measurable 'learning curve', and the attainment of the goals and targets can be affected by the adopted measures. We examine some of the available data on significant events, reportable occurrences, and loss of

The Meaning of Goodness-of-Fit Tests: Commentary on "Goodness-of-Fit Assessment of Item Response Theory Models"

Science.gov (United States)

Thissen, David

2013-01-01

In this commentary, David Thissen states that "Goodness-of-fit assessment for IRT models is maturing; it has come a long way from zero." Thissen then references prior works on "goodness of fit" in the index of Lord and Novick's (1968) classic text; Yen (1984); Drasgow, Levine, Tsien, Williams, and Mead (1995); Chen and…

National Interference in Local Public Good Provision

NARCIS (Netherlands)

A.J. Dur (Robert); K. Staal (Klaas)

2003-01-01

textabstractWe analyze a simple model of local public good provision in a country consisting of a large number of heterogeneous regions, each comprising two districts, a city and a village. When districts remain autonomous and local public goods have positive spillover effects on the neighbouring

Good governance in national solid waste management policy (NSWMP) implementation: A case study of Malaysia

Science.gov (United States)

Wee, Seow Ta; Abas, Muhamad Azahar; Mohamed, Sulzakimin; Chen, Goh Kai; Zainal, Rozlin

2017-10-01

The National Solid Waste Management Policy (NSWMP) was introduced in 2007 under the Act 672. The execution of NSWMP involves stakeholders from various government agencies and a collaboration with the private sectors. Despite the initiatives taken by the stakeholders, the objectives of NSWMP failed to materialise. One of the major constraints is weak governance among stakeholders with regards to the NSWMP implementation. This paper will explore the good governance practices implemented by the stakeholders. Identifying the current good governance practices implemented by the stakeholders is crucial as it will serve as a guideline to improve good governance practice in the future. An exploratory research approach is applied in this study through in-depth interviews with several government agencies and concessionaires involved in the NSWMP implementation. A total of six respondents took part in this study. The findings of this study show that there are several good governance practices implemented in policy promotion, participation of stakeholders, and capacity enhancement programme for the staff. This study also proposed some points on good governance practices in the context of policy promotion and staff development. A paradigm shift by the stakeholders is imperative so as to enhance the good governance practice in NSWMP implementation towards an efficient solid waste management in Malaysia.

Defending the four principles approach as a good basis for good medical practice and therefore for good medical ethics.

Science.gov (United States)

Gillon, Raanan

2015-01-01

This paper argues that the four prima facie principles-beneficence, non-maleficence, respect for autonomy and justice-afford a good and widely acceptable basis for 'doing good medical ethics'. It confronts objections that the approach is simplistic, incompatible with a virtue-based approach to medicine, that it requires respect for autonomy always to have priority when the principles clash at the expense of clinical obligations to benefit patients and global justice. It agrees that the approach does not provide universalisable methods either for resolving such moral dilemmas arising from conflict between the principles or their derivatives, or universalisable methods for resolving disagreements about the scope of these principles-long acknowledged lacunae but arguably to be found, in practice, with all other approaches to medical ethics. The value of the approach, when properly understood, is to provide a universalisable though prima facie set of moral commitments which all doctors can accept, a basic moral language and a basic moral analytic framework. These can underpin an intercultural 'moral mission statement' for the goals and practice of medicine. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Paying for international environmental public goods.

Science.gov (United States)

Arriagada, Rodrigo; Perrings, Charles

2011-11-01

Supply of international environmental public goods must meet certain conditions to be socially efficient, and several reasons explain why they are currently undersupplied. Diagnosis of the public goods failure associated with particular ecosystem services is critical to the development of the appropriate international response. There are two categories of international environmental public goods that are most likely to be undersupplied. One has an additive supply technology and the other has a weakest link supply technology. The degree to which the collective response should be targeted depends on the importance of supply from any one country. In principle, the solution for the undersupply lies in payments designed to compensate local providers for the additional costs they incur in meeting global demand. Targeted support may take the form of direct investment in supply (the Global Environment Facility model) or of payments for the benefits of supply (the Payments for Ecosystem Services model).

Conformity of Goods in International Sales

DEFF Research Database (Denmark)

Henschel, Rene Franz

The Conformity of Goods in International Sales gives a systematic analysis of Article 35 in the United Nations Convention on Contracts for the International Sale of Goods (CISG). Based on a detailed analysis of the most important cases and leading academic writing, Article 35 is described...... 9 CISG and the UNIDROIT Principles of International Commercial Contracts. The relation to domestic rules competing with Article 35, for instance the rules on validity and the rules on non-contractual liability, are analysed and so is the relation to selected domestic sales law, e.g. the United...... as a historical compromise between caveat emptor and caveat venditor and it is shown that the Article is to be supplemented by the general rules of contract law inside and outside the convention, such as the principle of good faith in Article 7 CISG, the rules of interpretation and usage in Article 8 and Article...

Reconsidering the "Good Divorce"

Science.gov (United States)

Amato, Paul R.; Kane, Jennifer B.; James, Spencer

2011-01-01

This study attempted to assess the notion that a "good divorce" protects children from the potential negative consequences of marital dissolution. A cluster analysis of data on postdivorce parenting from 944 families resulted in three groups: cooperative coparenting, parallel parenting, and single parenting. Children in the cooperative coparenting…

Good Governance in the EU

Directory of Open Access Journals (Sweden)

Gina Livioara GOGA

2009-10-01

Full Text Available Considering the EU adhesion, good governance has been analyzed from different perspectives, in the judicial literature being an analytic model or a normative concept. Some authors have wondered if this concept is a fashion, comprising some older ideas and principles, while other authors have asserted that the reasons why different methods of governance appear in the EU are based on “the complexity and the uncertainty of the problems on the agenda, an irreducible, the new approaches on public administration and law, hidden competencies, legitimacy and subsidiarity”. At a normative level, the White Paper of European Governance consecrated five principles on which good governance is based upon: openness, participation, responsibility, efficiency and coherence.

Freedom of Information, Records Management and Good ...

African Journals Online (AJOL)

Governments around the world are often praised for good or rebuked for bad governance. This paper argues that good governance is predicated on the adoption of functional records management and the enactment of Freedom of Information (FOI) legislation by governments. Records that are accumulated and used by ...

Conservation of filtering in manufacturing systems with unreliable machines and finished goods buffers

Directory of Open Access Journals (Sweden)

2006-01-01

Full Text Available This paper addresses the issue of reliable satisfaction of customer demand by unreliable production systems. In the framework of a simple production-storage-customer model, we show that this can be accomplished by using an appropriate level of filtering of production randomness. The filtering is ensured by finished goods buffers (filtering in space and shipping periods (filtering in time. The following question is considered: how are filtering in space and filtering in time interrelated? As an answer, we show that there exists a conservation law: in lean manufacturing systems, the amount of filtering in space multiplied by the amount of filteringin time (both measured in appropriate dimensionless units ispractically constant. Along with providing an insight into the nature of manufacturing systems, this law offers a tool for selecting the smallest, that is, lean, finished goods buffering, which is necessary and sufficient to ensure the desired level ofcustomer demand satisfaction.

Good Laboratory Practice. Part 3. Implementing Good Laboratory Practice in the Analytical Lab

Science.gov (United States)

Wedlich, Richard C.; Pires, Amanda; Fazzino, Lisa; Fransen, Joseph M.

2013-01-01

Laboratories submitting experimental results to the Food and Drug Administration (FDA) or the Environmental Protection Agency (EPA) in support of Good Laboratory Practice (GLP) nonclinical laboratory studies must conduct such work in compliance with the GLP regulations. To consistently meet these requirements, lab managers employ a "divide…

Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system.

Science.gov (United States)

Krebber, A; Bornhauser, S; Burmester, J; Honegger, A; Willuda, J; Bosshard, H R; Plückthun, A

1997-02-14

A prerequisite for the use of recombinant antibody technologies starting from hybridomas or immune repertoires is the reliable cloning of functional immunoglobulin genes. For this purpose, a standard phage display system was optimized for robustness, vector stability, tight control of scFv-delta geneIII expression, primer usage for PCR amplification of variable region genes, scFv assembly strategy and subsequent directional cloning using a single rare cutting restriction enzyme. This integrated cloning, screening and selection system allowed us to rapidly obtain antigen binding scFvs derived from spleen-cell repertoires of mice immunized with ampicillin as well as from all hybridoma cell lines tested to date. As representative examples, cloning of monoclonal antibodies against a his tag, leucine zippers, the tumor marker EGP-2 and the insecticide DDT is presented. Several hybridomas whose genes could not be cloned in previous experimental setups, but were successfully obtained with the present system, expressed high amounts of aberrant heavy and light chain mRNAs, which were amplified by PCR and greatly exceeded the amount of binding antibody sequences. These contaminating variable region genes were successfully eliminated by employing the optimized phage display system, thus avoiding time consuming sequencing of non-binding scFv genes. To maximize soluble expression of functional scFvs subsequent to cloning, a compatible vector series to simplify modification, detection, multimerization and rapid purification of recombinant antibody fragments was constructed.

Adaptive and bounded investment returns promote cooperation in spatial public goods games.

Directory of Open Access Journals (Sweden)

Xiaojie Chen

Full Text Available The public goods game is one of the most famous models for studying the evolution of cooperation in sizable groups. The multiplication factor in this game can characterize the investment return from the public good, which may be variable depending on the interactive environment in realistic situations. Instead of using the same universal value, here we consider that the multiplication factor in each group is updated based on the differences between the local and global interactive environments in the spatial public goods game, but meanwhile limited to within a certain range. We find that the adaptive and bounded investment returns can significantly promote cooperation. In particular, full cooperation can be achieved for high feedback strength when appropriate limitation is set for the investment return. Also, we show that the fraction of cooperators in the whole population can become larger if the lower and upper limits of the multiplication factor are increased. Furthermore, in comparison to the traditionally spatial public goods game where the multiplication factor in each group is identical and fixed, we find that cooperation can be better promoted if the multiplication factor is constrained to adjust between one and the group size in our model. Our results highlight the importance of the locally adaptive and bounded investment returns for the emergence and dominance of cooperative behavior in structured populations.

Why acting environmentally-friendly feels good: Exploring the role of self-image

Directory of Open Access Journals (Sweden)

Leonie A Venhoeven

2016-11-01

Full Text Available Recent research suggests that engagement in environmentally-friendly behavior can feel good. Current explanations for such a link do not focus on the nature of environmentally-friendly behavior itself, but rather propose well-being is more or less a side-benefit; behaviors that benefit environmental quality (e.g. spending one’s money on people rather than products also tend to make us feel good. We propose that the moral nature of environmentally-friendly behavior itself may elicit positive emotions as well, because engaging in this behavior can signal one is an environmentally-friendly and thus a good person. Our results show that engagement in environmentally-friendly behavior can indeed affect how people see themselves: participants saw themselves as being more environmentally-friendly when they engaged in more environmentally-friendly behavior (Study 1. Furthermore, environmentally-friendly behavior resulted in a more positive self-image, more strongly when it was voluntarily engaged in, compared to when it was driven by situational constraints (Study 2. In turn, the more environmentally-friendly (Study 1 and positive (Study 2 people saw themselves, the better they felt about acting environmentally-friendly. Together, these results suggest that the specific self-signal that ensues from engaging in environmentally-friendly behavior can explain why environmentally-friendly actions may elicit a good feeling.

24 CFR 3500.7 - Good faith estimate.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Good faith estimate. 3500.7 Section 3500.7 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT § 3500.7 Good faith estimate. (a) Lender to provide. (1...

Static and evolutionary quantum public goods games

Energy Technology Data Exchange (ETDEWEB)

Liao Zeyang; Qin Gan; Hu Lingzhi; Li Songjian; Xu Nanyang [Hefei National Laboratory for Physical Science at Microscale and Department of Modern Physics, University of Science and Technology of China, Hefei 230026 (China); Du Jiangfeng [Hefei National Laboratory for Physical Science at Microscale and Department of Modern Physics, University of Science and Technology of China, Hefei 230026 (China); Fachbereich Physik, Universitaet Dortmund, 44221 Dortmund (Germany)], E-mail: djf@ustc.edu.cn

2008-05-12

We apply the continuous-variable quantization scheme to quantize public goods game and find that new pure strategy Nash equilibria emerge in the static case. Furthermore, in the evolutionary public goods game, entanglement can also contribute to the persistence of cooperation under various population structures without altruism, voluntary participation, and punishment.

ISLAM, BUDAYA KORUPSI DAN GOOD GOVERNANCE

Directory of Open Access Journals (Sweden)

Ahmad Fawaid

2012-03-01

Full Text Available AbstractThe phenomenon and corruption action still becomes a fact that cannot be finished. One of causes is mentality of the world. It makes the cause why corruption becomes a massive culture. Beside restraining orientation of the world, good governance must become the priority. The result is that corruption does not become the culture anymore, and slowly but sure, it can be eliminated, or at least it can decrease.Kata-kata kuncikorupsi, budaya korupsi, indeks persepsi korupsi, good governance

Good cell culture practices &in vitro toxicology.

Science.gov (United States)

Eskes, Chantra; Boström, Ann-Charlotte; Bowe, Gerhard; Coecke, Sandra; Hartung, Thomas; Hendriks, Giel; Pamies, David; Piton, Alain; Rovida, Costanza

2017-12-01

Good Cell Culture Practices (GCCP) is of high relevance to in vitro toxicology. The European Society of Toxicology In Vitro (ESTIV), the Center for Alternatives for Animal Testing (CAAT) and the In Vitro Toxicology Industrial Platform (IVTIP) joined forces to address by means of an ESTIV 2016 pre-congress session the different aspects and applications of GCCP. The covered aspects comprised the current status of the OECD guidance document on Good In Vitro Method Practices, the importance of quality assurance for new technological advances in in vitro toxicology including stem cells, and the optimized implementation of Good Manufacturing Practices and Good Laboratory Practices for regulatory testing purposes. General discussions raised the duality related to the difficulties in implementing GCCP in an academic innovative research framework on one hand, and on the other hand, the need for such GCCP principles in order to ensure reproducibility and robustness of in vitro test methods for toxicity testing. Indeed, if good cell culture principles are critical to take into consideration for all uses of in vitro test methods for toxicity testing, the level of application of such principles may depend on the stage of development of the test method as well as on the applications of the test methods, i.e., academic innovative research vs. regulatory standardized test method. Copyright © 2017 Elsevier Ltd. All rights reserved.

What makes a good experiment ? reasons and roles in science

CERN Document Server

Franklin, Allan

2016-01-01

What makes a good experiment? Although experimental evidence plays an essential role in science, as Franklin argues, there is no algorithm or simple set of criteria for ranking or evaluating good experiments, and therefore no definitive answer to the question. Experiments can, in fact, be good in any number of ways: conceptually good, methodologically good, technically good, and pedagogically important. And perfection is not a requirement: even experiments with incorrect results can be good, though they must, he argues, be methodologically good, providing good reasons for belief in their results. Franklin revisits the same important question he posed in his 1981 article in the British Journal for the Philosophy of Science, when it was generally believed that the only significant role of experiment in science was to test theories. But experiments can actually play a lot of different roles in science—they can, for example, investigate a subject for which a theory does not exist, help to articulate an existing ...

Critical mass of public goods and its coevolution with cooperation

Science.gov (United States)

Shi, Dong-Mei; Wang, Bing-Hong

2017-07-01

In this study, the enhancing parameter represented the value of the public goods to the public in public goods game, and was rescaled to a Fermi-Dirac distribution function of critical mass. Public goods were divided into two categories, consumable and reusable public goods, and their coevolution with cooperative behavior was studied. We observed that for both types of public goods, cooperation was promoted as the enhancing parameter increased when the value of critical mass was not very large. An optimal value of critical mass which led to the best cooperation was identified. We also found that cooperations emerged earlier for reusable public goods, and defections became extinct earlier for the consumable public goods. Moreover, we observed that a moderate depreciation rate for public goods resulted in an optimal cooperation, and this range became wider as the enhancing parameter increased. The noise influence on cooperation was studied, and it was shown that cooperation density varied non-monotonically as noise amplitude increased for reusable public goods, whereas decreased monotonically for consumable public goods. Furthermore, existence of the optimal critical mass was also identified in other three regular networks. Finally, simulation results were utilized to analyze the provision of public goods in detail.

Pricing strategies for information goods

Indian Academy of Sciences (India)

Pricing strategies; information goods; bundling and versioning strategies; ... variety of industries including books, music, entertainment, gaming and education. ... Decision and Information Technologies Department, Robert H Smith School of ...

Integrating Education: Parekhian Multiculturalism and Good Practice

Science.gov (United States)

McGlynn, Claire

2009-01-01

This paper explores the concept of good practice in integrating education in divided societies. Using Northern Ireland as a case study, the paper draws on data from eight schools (both integrated Catholic and Protestant, and separate) that are identified as exemplifying good practice in response to cultural diversity. Analysis is provided through…

7 CFR 1499.7 - Transportation of goods.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Transportation of goods. 1499.7 Section 1499.7... Transportation of goods. (a) Shipments of donated commodities are subject to the requirements of 46 U.S.C. 55305 and 55314, regarding carriage on U.S.-flag vessels. (b) Transportation of donated commodities and...

7 CFR 1599.7 - Transportation of goods.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Transportation of goods. 1599.7 Section 1599.7... Transportation of goods. (a) Shipments of donated commodities are subject to the requirements of 46 U.S.C. 55305 and 55314, regarding carriage on U.S.-flag vessels. (b) Transportation of donated commodities and...

Customers Sustainability Demand : A comparison between convenience goods and shopping goods

OpenAIRE

Nilsson, Lisa; Höjman, Viktor; Elfqvist, Patrick

2015-01-01

In pace with a growing awareness among customers, so does the demand for sustainable products increase in various markets. Sustainability is even referred to become a mega-trend (Lubin & Esty, 2010). Although, extensive research can be found on sustainability and its three pillars; environment, social and economic, little is known whether there is a general customer demand for sustainability for any type of good. Therefore, this study’s purpose has been to compare sustainability demand fo...

Good Apple Homework Helper.

Science.gov (United States)

Cipriano, Jeri S.

This book, designed for students in grades 4 to 6, provides advice to help them do homework independently and successfully. Part 1, "Developing Good Habits," presents exercises and tips on organization and time management, including a self-inventory of homework habits, assistance in goal setting, and designing a personal schedule. Part 2, "Getting…

Globalisation and National Incentives for Protecting Environmental Goods

OpenAIRE

Alkuin Kölliker

2004-01-01

This article tries to explain national incentives for protecting environmental goods either autonomously or collectively; it explores how globalisation has affected those incentives; and it suggests how national environmental policy might respond so as to ensure its effectiveness. The central argument is that national incentives for environmental protection may to a considerable extent be explained by a combination of the type of environmental good to be protected (in terms of public goods th...

'Good Governance', Daya Saing dan Investasi Global

Directory of Open Access Journals (Sweden)

Zaenal Soedjais

2003-03-01

Full Text Available The on going process of globalization leaves no room for Indonesian access to global investment unless the country manage to ensure the competitivess its system. Improving institutional capacity to be able of delivering good governance and good corporate governenve are inevitable. The challenge is how to allow the market to perform optimally.

Good Teaching: Aligning Student and Administrator Perceptions and Expectations

Directory of Open Access Journals (Sweden)

Lazarus Nabaho

2017-03-01

Full Text Available Literature attests to limited systematic inquiry into students’ conceptions of good teaching in higher education. Resultantly, there have been calls for engaging students in construing what makes good university teaching and in developing a richer conception of teaching excellence. This interpretivist study that is based on views of final year university students from six academic disciplines investigated students’ conceptions of good teaching at Makerere University in Uganda. Students conceived good teaching as being student-centred, demonstrating strong subject and pedagogical knowledge, being approachable, being responsive, being organised, and being able to communicate well. Most of the conceptions of good teaching hinge  on what the teacher does (the means rather than affording high quality student learning (an end. It can therefore been concluded that good teaching is a multi-dimensional construct that defies a single definition and cannot be assured and assessed using a single indicator.

Adaptive evolution of cooperation through Darwinian dynamics in Public Goods games.

Science.gov (United States)

Deng, Kuiying; Chu, Tianguang

2011-01-01

The linear or threshold Public Goods game (PGG) is extensively accepted as a paradigmatic model to approach the evolution of cooperation in social dilemmas. Here we explore the significant effect of nonlinearity of the structures of public goods on the evolution of cooperation within the well-mixed population by adopting Darwinian dynamics, which simultaneously consider the evolution of populations and strategies on a continuous adaptive landscape, and extend the concept of evolutionarily stable strategy (ESS) as a coalition of strategies that is both convergent-stable and resistant to invasion. Results show (i) that in the linear PGG contributing nothing is an ESS, which contradicts experimental data, (ii) that in the threshold PGG contributing the threshold value is a fragile ESS, which cannot resist the invasion of contributing nothing, and (iii) that there exists a robust ESS of contributing more than half in the sigmoid PGG if the return rate is relatively high. This work reveals the significant effect of the nonlinearity of the structures of public goods on the evolution of cooperation, and suggests that, compared with the linear or threshold PGG, the sigmoid PGG might be a more proper model for the evolution of cooperation within the well-mixed population.

Diet and good health (image)

Science.gov (United States)

... especially important for children since a variety of food is needed for proper development. Other elements of good health include exercise, rest and avoidance of stimulants such as sugar and caffeine.

Punishment in public goods games leads to meta-stable phase transitions and hysteresis

Science.gov (United States)

Hintze, Arend; Adami, Christoph

2015-07-01

The evolution of cooperation has been a perennial problem in evolutionary biology because cooperation can be undermined by selfish cheaters who gain an advantage in the short run, while compromising the long-term viability of the population. Evolutionary game theory has shown that under certain conditions, cooperation nonetheless evolves stably, for example if players have the opportunity to punish cheaters that benefit from a public good yet refuse to pay into the common pool. However, punishment has remained enigmatic because it is costly and difficult to maintain. On the other hand, cooperation emerges naturally in the public goods game if the synergy of the public good (the factor multiplying the public good investment) is sufficiently high. In terms of this synergy parameter, the transition from defection to cooperation can be viewed as a phase transition with the synergy as the critical parameter. We show here that punishment reduces the critical value at which cooperation occurs, but also creates the possibility of meta-stable phase transitions, where populations can ‘tunnel’ into the cooperating phase below the critical value. At the same time, cooperating populations are unstable even above the critical value, because a group of defectors that are large enough can ‘nucleate’ such a transition. We study the mean-field theoretical predictions via agent-based simulations of finite populations using an evolutionary approach where the decisions to cooperate or to punish are encoded genetically in terms of evolvable probabilities. We recover the theoretical predictions and demonstrate that the population shows hysteresis, as expected in systems that exhibit super-heating and super-cooling. We conclude that punishment can stabilize populations of cooperators below the critical point, but it is a two-edged sword: it can also stabilize defectors above the critical point.

A novel method for in Situ detection of hydrolyzable casein fragments in a cheese matrix by antibody phage display technique and CLSM

DEFF Research Database (Denmark)

Duan, Zhi; Brüggemann, Dagmar Adeline; Siegumfeldt, Henrik

2009-01-01

three small synthetic peptides of the alpha(s1)-casein sequence. These peptides traverse enzymatic cleavage sites of casein during cheese ripening. The specificity of the generated anti-peptide antibodies was determined by ELISA and Western blot. Finally, an immunofluorescent labeling protocol......A novel method to monitor in situ hydrolyzable casein fragments during cheese ripening by using immunofluorescent labeling and confocal laser scanning microscopy (CLSM) was developed. Monoclonal single chain variable fragments of antibody (scFvs) were generated by antibody phage display toward...

Good Teaching: Aligning Student and Administrator Perceptions and Expectations

Science.gov (United States)

Nabaho, Lazarus; Oonyu, Joseph; Aguti, Jessica Norah

2017-01-01

Extant literature attests to limited systematic inquiry into students' perceptions of good teaching in higher education. Consequently, there have been calls for engaging students in construing what makes good university teaching. This interpretivist study investigated final-year undergraduate students' perceptions of good teaching at Makerere…

Rationality and the Logic of Good Reasons.

Science.gov (United States)

Fisher, Walter R.

This paper contends that the rationality of the logic of good reasons is constituted in its use. To support this claim, the paper presents an analysis of the relationship between being reasonable and being rational. It then considers how following the logic of good reasons leads to rationality in the behavior of individuals and groups; the latter…

Elderly Consumers and the Used Goods Economy.

Science.gov (United States)

Dobbs, Ralph C.

A study examined the used goods market as it affects older adults. A set of open-ended questions was administered to 100 respondents over sixty years of age who were either retired or near retirement, married or widowed, and suburban or rural. Interviews were conducted to derermine the effects of the used goods market on the elderly consumer, to…

Democracy, political participation and good governance in Nigeria

Directory of Open Access Journals (Sweden)

Dare E. Arowolo

2012-12-01

Full Text Available The practice of democracy in Nigeria over a decade ago has not yielded much needed good governance. This is because democracy is practiced in such a way that responsible and competent people are scared away. Scholars and keen observers have attempted at unraveling the factors militating against translating democracy into good governance. The paper revealed that democratisation in Nigeria is pervaded by electoral violence, manipulation of election results and political participation constraints. These identified challenges have made it impossible to attain consolidated democracy that can, in turn, facilitate good governance. Democracy is a catalyst for accountability, transparency and responsive government which brings about good governance. The paper insisted that governance collapse in Nigeria is reflexive of the perfunctory role of the political actors and it adopted elite theory to reinforce this argument. The paper adopted content analysis as a means of data gathering. It dwelt extensively on the synergy between democracy, political participation and good governance but queried the artificial gulf between them in Nigeria. It concluded by putting forth viable and pragmatic way forward.

Emissions from light and medium goods vehicles in Denmark

DEFF Research Database (Denmark)

Jørgensen, Kaj

1996-01-01

The article analyses atmospheric pollution of light goods vehicles (i.e. freight vehicles lighter than 6 tonnes) and medium goods vehicles (i.e. 6-24 t delivery trucks) in Denmark, and evaluated the scope for emission reductions. Light goods vehicles are very inefficient vehicles, and moreover have...

The Good, the Right & the Fair

DEFF Research Database (Denmark)

Gjerris, Mickey; Nielsen, Morten Ebbe Juul; Sandøe, Peter

The Good, the Right, and the Fair is a comprehensive introduction to contemporary moral and political philosophy especially suited for undergraduate students in medicine and the life sciences. The book covers first questions concerning the good: What makes a life worth living? Is it only humans who...... matter morally? Is welfare all that matters? It then proceeds to a discussion of the right: How ought we to act? The major ethical theories of the western tradition are presented and their strengths and weaknesses discussed. Finally, key aspects of the philosophical discussion of the fair, including...

Good faith in the context of restitution of cultural property

OpenAIRE

Midorović Sloboda D.

2016-01-01

The paper examines international and supranational rules on good faith in the context of restitution of cultural property. Deviations from the general rules on good faith with regard to the good faith acquisition and adverse possession have been indicated. Instead of insuring acquisition of ownership in conjunction with other preconditions, good faith only entitles an acquirer of the stolen or illegally exported cultural object to a fair compensation. The good faith presumption was abandoned ...

Could cash and good parenting affect child cognitive development? A cross-sectional study in South Africa and Malawi.

Science.gov (United States)

Sherr, Lorraine; Macedo, Ana; Tomlinson, Mark; Skeen, Sarah; Cluver, Lucie Dale

2017-05-12

Social protection interventions, including cash grants and care provision have been shown to effectively reduce some negative impacts of the HIV epidemic on adolescents and families. Less is known about the role of social protection on younger HIV affected populations. This study explored the impact of cash grants on children's cognitive development. Additionally, we examined whether combined cash and care (operationalised as good parenting) was associated with improved cognitive outcomes. The sample included 854 children, aged 5 - 15, participating in community-based organisation (CBO) programmes for children affected by HIV in South Africa and Malawi. Data on child cognitive functioning were gathered by a combination of caregiver report and observer administered tests. Primary caregivers also reported on the economic situation of the family, cash receipt into the home, child and household HIV status. Parenting was measured on a 10 item scale with good parenting defined as a score of 8 or above. About half of families received cash (55%, n = 473), only 6% (n = 51) reported good parenting above the cut-off point but no cash, 18% (n = 151) received combined cash support and reported good parenting, and 21% (n = 179) had neither. Findings show that cash receipt was associated with enhanced child cognitive outcomes in a number of domains including verbal working memory, general cognitive functioning, and learning. Furthermore, cash plus good parenting provided an additive effect. Child HIV status had a moderating effect on the association between cash or/plus good parenting and cognitive outcomes. The association between cash and good parenting and child cognitive outcomes remained significant among both HIV positive and negative children, but overall the HIV negative group benefited more. This study shows the importance of cash transfers and good parenting on cognitive development of young children living in HIV affected environments. Our data clearly

The Good Investment.

Science.gov (United States)

Prescott, John E; Fresne, Julie A; Youngclaus, James A

2017-07-01

The authors reflect on the article in this issue entitled "Borrow or Serve? An Economic Analysis of Options for Financing a Medical School Education" by Marcu and colleagues, which makes a compelling case that a medical school education is a good investment, no matter what financing option students use, from federal service programs to federal loans. The lead author of this Commentary shares lessons learned from his own medical school education, which was funded by an Armed Forces Health Professions Scholarship, and from his current position interacting with medical students across the United States.Regardless of the financing path they choose, all students should understand basic financial concepts and the details of the various pathways that are available to pay for their medical school education, as well as how each could potentially impact their own future and that of their families. One underappreciated aspect of financing a medical school education is that federal repayment scenarios can link loan payments to income, rather than debt levels, which means that all physicians are able to afford their loan payments no matter what specialty they practice, what they are paid, or where they live.Medical education, while expensive, remains the good investment. An MD degree can lead to a lifetime of personal fulfillment and societal contributions. Everyone, with rare exceptions, accepted to a U.S. medical school will be able to finance their medical education via a path that aligns with their personal values and priorities.

Federalism, Education-Related Public Good and Growth when Agents are Heterogeneou

OpenAIRE

Floriana Cerniglia; Riccarda Longaretti

2008-01-01

In this paper we use an endogeneous-growth model with human capital and heterogeneous agents to analyse the relationship between fiscal federalism and economic growth. Results show that federalism, which allows education-related public good levels to be tailored on the human capital of heterogeneous agents, increases human capital accumulation. This in turn leads to higher rates of growth. The benefits of federalism are stronger the larger the intra-jurisdiction variance of agents’ human capi...

Internal Control Good Cooperative Governance And Performance

Directory of Open Access Journals (Sweden)

Andry Arifian Rachman

2017-11-01

Full Text Available This study aims to examine the influence of internal control and good cooperative governance partially and simultaneously to the performance of cooperatives in West Java Province. The research method used in this research is descriptive and verification. The sample in this research is 22 boards as manager of cooperative in West Java Province. The data used in the research is the primary data through questionnaire collection. Validity and reliability testing is performed before hypothesis testing. This research uses multiple regression analysis technique. Based on hypothesis testing obtained 1 internal control has no significant effect on performance 2 good cooperative governance has a significant effect on performance and 3 internal control and good cooperative governance have a significant effect on performance.

Knowledge asymmetries about product "goodness"

DEFF Research Database (Denmark)

Kampf, Constance

and actions towards workers, and findings of independent researchers.  Currently, differing perspectives on product "goodness" are being addressed and mediated by NGOs and B-corporations, as they work with private companies and corporations to communicate product information to consumers.  One organization...... focused on scenarios where shoppers were asked about CSR in their product decisions found that: "...when consumers are given information that they trust about a company's level of social responsibility, it affects how they evaluate the company and their purchase intentions. Furthermore, a low price did.......  Asymmetries in knowledge about product "goodness" make it difficult for ethically inspired consumers to make informed decisions about the products they purchase.  These knowledge asymmetries emerge from differing perspectives on guidelines for consumer safety set by government bodies, CSR initiatives...

Creating conditions for good nursing by attending to the spiritual.

Science.gov (United States)

Biro, Anne L

2012-12-01

To note similarities, differences, and gaps in the literature on good nursing and spiritual care. Good nursing care is essential for meeting patient health needs. With growing recognition of the role of spirituality in health, understanding spiritual care as it relates to good nursing is important, especially as spiritual care has been recognized as the most neglected area of nursing care. Nursing research, reports and discussion articles from a variety of countries were reviewed on the topics of good nursing, spiritual care and spirituality. A nurse's spirituality and the nurse-patient relationship are integral to spiritual care and good nursing. There are many commonalities between good nursing and spiritual care. Personal attributes of the nurse are described in similar terms in research on spiritual care and good nursing. Professional attributes common to good nursing and spiritual care are the nurse-patient relationship, assessment skills and communication skills. Good nursing through spiritual care is facilitated by personal spirituality, training in spiritual care and a culture that implements changes supportive of spiritual care. Further research is needed to address limitations in the scope of literature. © 2012 Blackwell Publishing Ltd.

21 CFR 1271.150 - Current good tissue practice requirements.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Current good tissue practice requirements. 1271... HUMAN CELLS, TISSUES, AND CELLULAR AND TISSUE-BASED PRODUCTS Current Good Tissue Practice § 1271.150 Current good tissue practice requirements. (a) General. This subpart D and subpart C of this part set...

A Global Public Goods Approach to the Health of Migrants.

Science.gov (United States)

Widdows, Heather; Marway, Herjeet

2015-07-01

This paper explores a global public goods approach to the health of migrants. It suggests that this approach establishes that there are a number of health goods which must be provided to migrants not because these are theirs by right (although this may independently be the case), but because these goods are primary goods which fit the threefold criteria of global public goods. There are two key advantages to this approach: first, it is non-confrontational and non-oppositional, and second, it provides self-interested arguments to provide at least some health goods to migrants and thus appeals to those little moved by rights-based arguments.

Good manufacturing practice

International Nuclear Information System (INIS)

Schlyer, D.J.

2001-01-01

In this presentation author deals with the Implementation of good manufacturing practice for radiopharmaceuticals. The presentation is divided into next parts: Batch size; Expiration date; QC Testing; Environmental concerns; Personnel aspects; Radiation concerns; Theoretical yields; Sterilizing filters; Control and reconciliation of materials and components; Product strength; In process sampling and testing; Holding and distribution; Drug product inspection; Buildings and facilities; Renovations at BNL for GMP; Aseptic processing and sterility assurance; Process validation and control; Quality control and drug product stability; Documentation and other GMP topics; Building design considerations; Equipment; and Summary

Goodness-of-fit tests for multi-dimensional copulas: Expanding application to historical drought data

Directory of Open Access Journals (Sweden)

Ming-wei Ma

2013-01-01

Full Text Available The question of how to choose a copula model that best fits a given dataset is a predominant limitation of the copula approach, and the present study aims to investigate the techniques of goodness-of-fit tests for multi-dimensional copulas. A goodness-of-fit test based on Rosenblatt's transformation was mathematically expanded from two dimensions to three dimensions and procedures of a bootstrap version of the test were provided. Through stochastic copula simulation, an empirical application of historical drought data at the Lintong Gauge Station shows that the goodness-of-fit tests perform well, revealing that both trivariate Gaussian and Student t copulas are acceptable for modeling the dependence structures of the observed drought duration, severity, and peak. The goodness-of-fit tests for multi-dimensional copulas can provide further support and help a lot in the potential applications of a wider range of copulas to describe the associations of correlated hydrological variables. However, for the application of copulas with the number of dimensions larger than three, more complicated computational efforts as well as exploration and parameterization of corresponding copulas are required.

Research on Design Information Management System for Leather Goods

Science.gov (United States)

Lu, Lei; Peng, Wen-li

The idea of setting up a design information management system of leather goods was put forward to solve the problems existed in current information management of leather goods. Working principles of the design information management system for leather goods were analyzed in detail. Firstly, the acquiring approach of design information of leather goods was introduced. Secondly, the processing methods of design information were introduced. Thirdly, the management of design information in database was studied. Finally, the application of the system was discussed by taking the shoes products as an example.

TOURISM, TRADE, EXTERNALITIES, AND PUBLIC GOODS IN A THREE-SECTOR GROWTH MODEL

Directory of Open Access Journals (Sweden)

Wei-Bin Zhang

2015-06-01

Full Text Available The purpose of this study is to introduce tourism, externalities, and public goods to a small-open growth with endogenous wealth and public goods supply. We develop the model on the basis of the Solow-Uzawa growth model, the neoclassical neoclassical growth theory with externalities, and ideas from tourism economics. The economy consists of three – service, industrial, and public - sectors. The production side is based on the traditional growth theories, while the household behavior is described by an alternative utility function proposed by Zhang. We introduce endogenous land distribution between housing and supply of services. The industrial and service sectors are perfectly competitive subject to the government’s taxation. The public sector is financially supported by the government. We introduce taxes not only on producers, but also on consumers’ incomes from wage, land, and interest of wealth, consumption of goods and services, and housing. We simulate the motion of the national economy and show the existence of a unique stable equilibrium. We carry out comparative dynamic analysis with regard to the rate of interest in the global market, the total productivity of the service sector, tax rate on the service sector, tax rate on consumption of services, human capital, the propensity to consume services, and the impact of public services on the productivity of the industrial sector. The comparative dynamic analysis provides some important insights into the complexity of open economies with endogenous wealth, public goods, and externalities.

Meta-analysis suggests choosy females get sexy sons more than "good genes".

Science.gov (United States)

Prokop, Zofia M; Michalczyk, Łukasz; Drobniak, Szymon M; Herdegen, Magdalena; Radwan, Jacek

2012-09-01

Female preferences for specific male phenotypes have been documented across a wide range of animal taxa, including numerous species where males contribute only gametes to offspring production. Yet, selective pressures maintaining such preferences are among the major unknowns of evolutionary biology. Theoretical studies suggest that preferences can evolve if they confer genetic benefits in terms of increased attractiveness of sons ("Fisherian" models) or overall fitness of offspring ("good genes" models). These two types of models predict, respectively, that male attractiveness is heritable and genetically correlated with fitness. In this meta-analysis, we draw general conclusions from over two decades worth of empirical studies testing these predictions (90 studies on 55 species in total). We found evidence for heritability of male attractiveness. However, attractiveness showed no association with traits directly associated with fitness (life-history traits). Interestingly, it did show a positive correlation with physiological traits, which include immunocompetence and condition. In conclusion, our results support "Fisherian" models of preference evolution, while providing equivocal evidence for "good genes." We pinpoint research directions that should stimulate progress in our understanding of the evolution of female choice. © 2012 The Author(s). Evolution© 2012 The Society for the Study of Evolution.

Chi-squared goodness of fit tests with applications

CERN Document Server

Balakrishnan, N; Nikulin, MS

2013-01-01

Chi-Squared Goodness of Fit Tests with Applications provides a thorough and complete context for the theoretical basis and implementation of Pearson's monumental contribution and its wide applicability for chi-squared goodness of fit tests. The book is ideal for researchers and scientists conducting statistical analysis in processing of experimental data as well as to students and practitioners with a good mathematical background who use statistical methods. The historical context, especially Chapter 7, provides great insight into importance of this subject with an authoritative author team

Prevention of infectious diseases in patients with Good syndrome.

Science.gov (United States)

Multani, Ashrit; Gomez, Carlos A; Montoya, José G

2018-08-01

Good syndrome is a profoundly immunocompromising condition with heterogeneous immune deficits characterized by the presence of thymoma, low-to-absent B-lymphocyte counts, hypogammaglobulinemia, and impaired cell-mediated immunity. Opportunistic infectious diseases associated with Good syndrome represent a diagnostic and therapeutic challenge, given their protean clinical manifestations. Although these infectious complications have been reviewed in prior publications, recommendations regarding their prevention have been lacking. Good syndrome usually occurs in adult patients between the ages of 40 and 70 years. Immunologically, it is characterized by low or absent peripheral blood B lymphocytes, hypogammaglobulinemia, and variable defects in cell-mediated immunity including low CD4 T counts, inverted CD4:CD8 T-lymphocyte ratio, and reduced T-lymphocyte mitogen proliferative responses. Patients with Good syndrome are susceptible to a variety of infectious diseases, of which the most common are recurrent bacterial sinopulmonary infections, mucocutaneous candidiasis, and CMV tissue-invasive disease. Preventive guidelines including targeted antimicrobial prophylaxis and vaccination strategies can mitigate infectious complications in patients with Good syndrome. Immunological deficits and infectious complications in Good syndrome have been described for over 60 years. Further research is needed to elucidate its exact pathogenesis and define the mechanistic relationship between thymoma and hypogammaglobulinemia. However, tailored prophylactic strategies can be recommended for patients with Good syndrome.

Good Mathematics Teaching from Mexican High School Students' Perspective

Science.gov (United States)

Martinez-Sierra, Gustavo

2014-01-01

This paper reports a qualitative research that identifies the characteristics of good mathematics teaching from the perspective of Mexican high school students. For this purpose, the social representations of a good mathematics teacher and a good mathematics class were identified in a group of 67 students. In order to obtain information, a…

Electoral management bodies as institutions of good governance ...

African Journals Online (AJOL)

) must hold regular participative elections. Similarly, for good governance to be sustainable, the system must be open, accountable and participative. Participation in election on its own is a process of good governance. The paper argues that ...

["Good dying"--definition and current state of research].

Science.gov (United States)

Hutter, Nico; Stößel, Ulrich; Meffert, Cornelia; Körner, Mirjam; Bozzaro, Claudia; Becker, Gerhild; Baumeister, Harald

2015-08-01

The advances of modern medicine did not only result in prolongation of life expectancy, but also led to a shift from dying at home to dying in public institutions. In western countries most people die at advanced age in medical facilities. Hence, the question regarding the conditions, which should be provided by society and especially medicine, to allow terminally ill people to experience "good dying" is substantial. For this purpose, an examination of patients', family members' and health care providers' understanding of the term " good dying" is required. The present paper aims at shedding light on the term "good dying" and to summarize the current state of research. Therefore, the attributes of "good dying" will be described from the perspectives of patients, family members and health care providers, which are discussed and examined in current medical-sociological research. These attributes can be illustrated on three dimensions: Quality of life at the end of life (e. g. pain relief, mental well-being), quality of dying (e. g. avoiding prolonged dying, autonomy, presence of relatives) and quality of health care at the end of life (e. g. patient-oriented health care, positive communication between health care providers and patients, availability of guidelines). Although the attributes of "good dying" are described in detail in the existing literature, further studies have to clarify the relevance and impact of these attributes as predictors of "good dying". © Georg Thieme Verlag KG Stuttgart · New York.

4 Challenges & Solutions to Getting a Good Night's Sleep

Science.gov (United States)

A good night’s sleep makes you feel better and gives you the energy you need to face the world. But, some women have trouble getting a good night’s sleep. Here are some of the reasons women have trouble sleeping and some things you can do to get a good night’s rest.

The officials’ efforts to set up a good government

Science.gov (United States)

Suardini, D.; Mariana, D.; Sjoraida, D. F.

2018-03-01

This study investigates the Government of Bogor City’s efforts in disseminating the values of good governance to its bureaucracy. This is based on the fact that the enforcement of good governance is a challenge and an opportunity to be concerned because there are many who do not know the impact of it. Internal impacts would be felt in the employment sector competition while the external impact would be related to the competition in terms of the governance qualities from another region examined by the internal affair officials. With descriptive and qualitative approaches, this study finds that many officials of the local government of Bogor City are still not ready to face the culture of good governance. Such unpreparedness results from the fact that an understanding of good governance is not evenly spread among the officials. It is because that the government itself has not put this good governance issue as a top priority. Finally, there is the absence of a comprehensive evaluation process of good government socialization activities.

U.S. international trade in transportation-related goods

Science.gov (United States)

2003-06-01

Trade in motor vehicles and parts makes up three : of every four dollars that the U.S. trades in : transportation-related goods. : Canada is the United States' leading trade partner : in transportation-related goods, followed by : Japan and Mexic...

Is Social Capital a Good Concept?

DEFF Research Database (Denmark)

Bjørnskov, Christian; Sønderskov, Kim Mannemar

The aim of this paper is to explore whether the concept of social capital as popularized by Robert Putnam is a good social science concept. Taken Gerring’s and Adcock and Collier’s work on concept formation and measurement validity as the starting point, the paper first discusses necessary...... conditions for concepts to be good in a strict sense. Afterwards, an empirical section explores the validity of the unidimensionality assumption of most definitions of social capital. This assumption is rejected in four separate tests at both the micro and macro level. A final section therefore discusses...

Good practices in early childhood education:

DEFF Research Database (Denmark)

Sanders, Lise; Gregoriadis, Athanasis; Zachopoulou, Evridiki

Good practices in early childhood education er en undersøgelse fortaget efter Early Childhood Environmental Rating Scale - R (ECERS-R). I undersøgelsen deltog Akademikere, pædagoger og kommunalt personale fra de 6 partnerlande bestående af Grækenland, Portugal, Finland, Danmark, Rumænien og Cypern....... Undersøgelsen fokuserede på indsamling af Good practice inden for 5 specifikke kategorier af daglig praksis i børnehaver og børnehaveklasser. Plads og Inventar Personlige omsorgsrutiner Sprog - Tænkning Aktiviteter Interaktioner Struktur Projektet er støttet af Lifelong learning programme of the European Union...

Show-Bix &

DEFF Research Database (Denmark)

2014-01-01

The anti-reenactment 'Show-Bix &' consists of 5 dias projectors, a dial phone, quintophonic sound, and interactive elements. A responsive interface will enable the Dias projectors to show copies of original dias slides from the Show-Bix piece ”March på Stedet”, 265 images in total. The copies are...

Transplantation as an abstract good

DEFF Research Database (Denmark)

Hoeyer, Klaus; Jensen, Anja Marie Bornø; Olejaz, Maria

2015-01-01

This article investigates valuations of organ transfers that are currently seen as legitimising increasingly aggressive procurement methods in Denmark. Based on interviews with registered donors and the intensive care unit staff responsible for managing organ donor patients we identify three types...... a more general salience in the organ transplant field by way of facilitating a perception of organ transplantation as an abstract moral good rather than a specific good for specific people. Furthermore, we suggest that multiple forms of ignorance sustain each other: a desire for ignorance with respect...... to the prioritisation of recipients sustains pressure for more organs; this pressure necessitates more aggressive measures in organ procurement and these measures increase the need for ignorance in relation to the actual procedures as well as the actual recipients. These attempts to avoid knowledge are in remarkable...

'Good Governance' dan 'Governability'

Directory of Open Access Journals (Sweden)

- Pratikno

2005-03-01

Full Text Available The article endeavors to trace the outset of governance concept, its dominant meanings and discourse, and its implication towards governability. The central role of government in the governing processes has predominantly been adopted. The concept of governance was emerged precisely in the context of the failure of government as key player in regulation, economic redistribution and political participation. Governance is therefore aimed to emphasize pattern of governing which are based both on democratic mechanism and sound development management. However, practices of such good governance concept –which are mainly adopted and promoted by donor states and agencies– tend to degrade state and/or government authority and legitimacy. Traditional function of the state as sole facilitator of equal societal, political and legal membership among citizens has been diminished. The logic of fair competition has been substituted almost completely by the logic of free competition in nearly all sectors of public life. The concept and practices of good governance have resulted in decayed state authority and failed state which in turn created a condition for "ungovernability". By promoting democratic and humane governance, the article accordingly encourages discourse to reinstall and bring the idea of accountable state back in.

Neighborhood scale quantification of ecosystem goods and services

Science.gov (United States)

Ecosystem goods and services are those ecological structures and functions that humans can directly relate to their state of well-being. Ecosystem goods and services include, but are not limited to, a sufficient fresh water supply, fertile lands to produce agricultural products, ...

The clustering evolution of distant red galaxies in the GOODS-MUSIC sample

Science.gov (United States)

Grazian, A.; Fontana, A.; Moscardini, L.; Salimbeni, S.; Menci, N.; Giallongo, E.; de Santis, C.; Gallozzi, S.; Nonino, M.; Cristiani, S.; Vanzella, E.

2006-07-01

Aims.We study the clustering properties of Distant Red Galaxies (DRGs) to test whether they are the progenitors of local massive galaxies. Methods.We use the GOODS-MUSIC sample, a catalog of ~3000 Ks-selected galaxies based on VLT and HST observation of the GOODS-South field with extended multi-wavelength coverage (from 0.3 to 8~μm) and accurate estimates of the photometric redshifts to select 179 DRGs with J-Ks≥ 1.3 in an area of 135 sq. arcmin.Results.We first show that the J-Ks≥ 1.3 criterion selects a rather heterogeneous sample of galaxies, going from the targeted high-redshift luminous evolved systems, to a significant fraction of lower redshift (1mass, like groups or small galaxy clusters. Low-z DRGs, on the other hand, will likely evolve into slightly less massive field galaxies.

Images of eyes enhance investments in a real-life public good.

Directory of Open Access Journals (Sweden)

Damien Francey

Full Text Available A key issue in cooperation research is to determine the conditions under which individuals invest in a public good. Here, we tested whether cues of being watched increase investments in an anonymous public good situation in real life. We examined whether individuals would invest more by removing experimentally placed garbage (paper and plastic bottles from bus stop benches in Geneva in the presence of images of eyes compared to controls (images of flowers. We provided separate bins for each of both types of garbage to investigate whether individuals would deposit more items into the appropriate bin in the presence of eyes. The treatment had no effect on the likelihood that individuals present at the bus stop would remove garbage. However, those individuals that engaged in garbage clearing, and were thus likely affected by the treatment, invested more time to do so in the presence of eyes. Images of eyes had a direct effect on behaviour, rather than merely enhancing attention towards a symbolic sign requesting removal of garbage. These findings show that simple images of eyes can trigger reputational effects that significantly enhance on non-monetary investments in anonymous public goods under real life conditions. We discuss our results in the light of previous findings and suggest that human social behaviour may often be shaped by relatively simple and potentially unconscious mechanisms instead of very complex cognitive capacities.

Bootstrap Power of Time Series Goodness of fit tests

Directory of Open Access Journals (Sweden)

Sohail Chand

2013-10-01

Full Text Available In this article, we looked at power of various versions of Box and Pierce statistic and Cramer von Mises test. An extensive simulation study has been conducted to compare the power of these tests. Algorithms have been provided for the power calculations and comparison has also been made between the semi parametric bootstrap methods used for time series. Results show that Box-Pierce statistic and its various versions have good power against linear time series models but poor power against non linear models while situation reverses for Cramer von Mises test. Moreover, we found that dynamic bootstrap method is better than xed design bootstrap method.

7 CFR 28.421 - Good Middling Spotted Color.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Good Middling Spotted Color. 28.421 Section 28.421 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... Color. Good Middling Spotted Color is color which is better than Strict Middling Spotted Color. ...

Promotion of good governance and combating corruption and ...

African Journals Online (AJOL)

Melvin Mbao and G.G Komboni criticise the legal regime and institutional arrangements designed to promote good government and to combat corruption and maladministration in Botswana, a country widely acclaimed as Africa's success story. Using internationally accepted benchmarks on good governance and combating ...

Managers' duty to maintain good workplace communications skills.

Science.gov (United States)

Timmins, Fiona

2011-06-01

Communication is a fundamental element of care at every level of nursing practice. It is important, therefore, for nurse managers to create environments that promote and encourage good communication, and help nurses to develop their communication skills formally and informally. This article discusses the effects of communication on the quality of care. It examines nurses' professional duty to maintain good communication skills and how managers can help them do this. It also discusses nurse managers' communication skills in the context of leadership style, conflict resolution and self-awareness. Finally, it considers the notion of shared governance as good practice.

GOOD INTENTION ON ELECTRONIC CONTRACT THROUGH E-COMMERCE

Directory of Open Access Journals (Sweden)

Ari Purwadi

2015-12-01

Full Text Available Electronic contract (e-contract is a contract that vulnerable to the emersion of problems because the contract happened between absence persons. This problem can be avoided if businessman who included in the electronic commerce using principle of good intention. According to the Information and Electronic Transactions Act declare that good intention shall be given during the transaction taking place, it must be interpreted both in the pre-transaction stage, transaction stage, and post-transaction phase. Thus, in order to protect consumer, it's good intention should be exist in every phase of consumer transaction.

Good veterinary governance: definition, measurement and challenges.

Science.gov (United States)

Msellati, L; Commault, J; Dehove, A

2012-08-01

Good veterinary governance assumes the provision of veterinary services that are sustainably financed, universally available, and provided efficiently without waste or duplication, in a manner that is transparent and free of fraud or corruption. Good veterinary governance is a necessary condition for sustainable economic development insomuch as it promotes the effective delivery of services and improves the overall performance of animal health systems. This article defines governance in Veterinary Services and proposes a framework for its measurement. It also discusses the role of Veterinary Services and analyses the governance dimensions of the performance-assessment tools developed by the World Organisation for Animal Health (OIE). These tools (OIE PVS Tool and PVS Gap Analysis) track the performance of Veterinary Services across countries (a harmonised tool) and over time (the PVS Pathway). The article shows the usefulness of the OIE PVS Tool for measuring governance, but also points to two shortcomings, namely (i) the lack of clear outcome indicators, which is an impediment to a comprehensive assessment of the performance of Veterinary Services, and (ii) the lack of specific measures for assessing the extent of corruption within Veterinary Services and the extent to which demand for better governance is being strengthened within the animal health system. A discussion follows on the drivers of corruption and instruments for perception-based assessments of country governance and corruption. Similarly, the article introduces the concept of social accountability, which is an approach to enhancing government transparency and accountability, and shows how supply-side and demand-side mechanisms complement each other in improving the governance of service delivery. It further elaborates on two instruments--citizen report card surveys and grievance redress mechanisms--because of their wider relevance and their possible applications in many settings, including Veterinary

LHC Report: machine commissioning - looking good

CERN Document Server

CERN Bulletin

2016-01-01

Since first beam was injected on Friday, 25 March, the recommissioning of the LHC has made good progress.   An event display showing the first collisions after the 2015 year-end technical stop as seen by the CMS experiment. At present, work is being performed with either probe bunches (around 1010 protons per bunch) or single nominal bunches (1.1 x 1011 protons per bunch). This procedure is intended to ensure safe operation before full qualification of the machine protection set-up. Beam has been taken up the ramp to 6.5 TeV and through the squeeze to the planned 2016 operating scenario. The optics (i.e. the global focusing properties of the whole ring) have been measured and corrected to an unprecedented level: there is now excellent agreement between the machine model and the actual LHC. Some preliminary measurements of the global aperture have been performed and there are no apparent bottlenecks. The position of the ULO (Unidentified Lying Object) had been probed and it is in a similar positio...

Benefits of tolerance in public goods games.

Science.gov (United States)

Szolnoki, Attila; Chen, Xiaojie

2015-10-01

Leaving the joint enterprise when defection is unveiled is always a viable option to avoid being exploited. Although loner strategy helps the population not to be trapped into the tragedy of the commons state, it could offer only a modest income for nonparticipants. In this paper we demonstrate that showing some tolerance toward defectors could not only save cooperation in harsh environments but in fact results in a surprisingly high average payoff for group members in public goods games. Phase diagrams and the underlying spatial patterns reveal the high complexity of evolving states where cyclic dominant strategies or two-strategy alliances can characterize the final state of evolution. We identify microscopic mechanisms which are responsible for the superiority of global solutions containing tolerant players. This phenomenon is robust and can be observed both in well-mixed and in structured populations highlighting the importance of tolerance in our everyday life.

Goodness-of-fit tests with dependent observations

International Nuclear Information System (INIS)

Chicheportiche, Rémy; Bouchaud, Jean-Philippe

2011-01-01

We revisit the Kolmogorov–Smirnov and Cramér–von Mises goodness-of-fit (GoF) tests and propose a generalization to identically distributed, but dependent univariate random variables. We show that the dependence leads to a reduction of the 'effective' number of independent observations. The generalized GoF tests are not distribution-free but rather depend on all the lagged bivariate copulas. These objects, that we call 'self-copulas', encode all the non-linear temporal dependences. We introduce a specific, log-normal model for these self-copulas, for which a number of analytical results are derived. An application to financial time series is provided. As is well known, the dependence is to be long-ranged in this case, a finding that we confirm using self-copulas. As a consequence, the acceptance rates for GoF tests are substantially higher than if the returns were iid random variables

Self-serving punishment of a common enemy creates a public good in reef fishes.

Science.gov (United States)

Bshary, Andrea; Bshary, Redouan

2010-11-23

A key challenge for evolutionary biologists is to determine conditions under which individuals benefit from a contribution to public goods [1, 2]. For humans, it has been observed that punishment of free riders may promote contributions [3, 4], but the conditions that lead to stable cooperation based on punishment remain hotly debated [5-8]. Here we present empirical evidence that public goods may emerge as a by-product of self-serving punishment in interactions between coral reef fishes and parasitic saber-tooth blennies that stealthily attack their fish victims from behind to take a bite [9]. We first show that chasing the blenny functions as punishment [10], because it decreases the probability of future attacks. We then provide evidence that in female scalefin anthias, a shoaling species, punishment creates a public good because it increases the probability that the parasite switches to another species for the next attack. A final experiment suggests that punishment is nevertheless self-serving because blennies appear to be able to discriminate between look-alike punishers and nonpunishers. Thus, individuals that do contribute to the public good may risk being identified by the parasite as easy targets for future attacks. Copyright © 2010 Elsevier Ltd. All rights reserved.

Good Faith in Life Insurance Contract by Indonesian Court

Directory of Open Access Journals (Sweden)

Mokhamad Khoirul Huda

2017-03-01

Full Text Available This paper reviews both the interpretation of good faith and its implementation by the Court in terms of life insurance contracts. The principle of good faith in life insurance contracts was under the provision of the Article 251 Wet Boek van Kophandel which assigned the obligation of good faith on the insured. Based on the context of its historical and systematical interpretation, the obligation of good faith should be on both sides, the insurer and the insured. The insured had an obligation to inform any material facts and the insurer had to investigate those all facts. Until recent days, however, judges in all levels of Court did not have any shared and full understanding on the interpretation of good faith in life insurance contracts. As the result, many Courts were frequently inconsistent with each other. Hence, the sense of fairness the people perceived from the court verdict was not achieved.

19 CFR 10.599 - Fungible goods and materials.

Science.gov (United States)

2010-04-01

... THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. Dominican Republic-Central... either on the physical segregation of the fungible good or material or by using an inventory management method with respect to the fungible good or material. For purposes of this section, the term “inventory...

21 CFR 123.5 - Current good manufacturing practice.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Current good manufacturing practice. 123.5 Section...) FOOD FOR HUMAN CONSUMPTION FISH AND FISHERY PRODUCTS General Provisions § 123.5 Current good manufacturing practice. (a) Part 110 of this chapter applies in determining whether the facilities, methods...

7 CFR 51.481 - Very good internal quality.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Very good internal quality. 51.481 Section 51.481 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... quality. Very good internal quality means that the combined juice from the edible portion of a sample of...

Derivation of the Radioactivity Index for Consumer Goods Containing NORM

Energy Technology Data Exchange (ETDEWEB)

Jang, Mee; Chung, Kun Ho; Ji, Young Yong; Kim, Chang Jong; Kang, Mun Ja [KAERI, Daejeon (Korea, Republic of)

2016-05-15

Some consumer goods to promote health such as anion bracelets, necklace and mats contain naturally occurring radioactive material (NORM). Some of them can cause problems because of high radioactivity. In the regulations, there is an annual effective dose limit of 1mSv for products, but the activity concentration limits and radioactivity index for products is not established yet. Although there are few researches for consumer goods containing NORM in foreign countries, in Japan, for the consumer goods. To regulate the NORM in consumer goods, it is necessary to derive activity concentration limits corresponding to the annual limits of 1mSv. In this research, we calculated the activity concentration limits according to the usage quantities of consumer goods. Using these results, it is possible to suggest several radioactivity indexes to apply to a lot of consumer goods.

Derivation of the Radioactivity Index for Consumer Goods Containing NORM

International Nuclear Information System (INIS)

Jang, Mee; Chung, Kun Ho; Ji, Young Yong; Kim, Chang Jong; Kang, Mun Ja

2016-01-01

Some consumer goods to promote health such as anion bracelets, necklace and mats contain naturally occurring radioactive material (NORM). Some of them can cause problems because of high radioactivity. In the regulations, there is an annual effective dose limit of 1mSv for products, but the activity concentration limits and radioactivity index for products is not established yet. Although there are few researches for consumer goods containing NORM in foreign countries, in Japan, for the consumer goods. To regulate the NORM in consumer goods, it is necessary to derive activity concentration limits corresponding to the annual limits of 1mSv. In this research, we calculated the activity concentration limits according to the usage quantities of consumer goods. Using these results, it is possible to suggest several radioactivity indexes to apply to a lot of consumer goods

Promoting good health research practice in low- and middle-income countries.

Science.gov (United States)

Mahendradhata, Yodi; Nabieva, Jamila; Ahmad, Riris Andono; Henley, Patricia; Launois, Pascal; Merle, Corinne; Maure, Christine; Horstick, Olaf; Elango, Varalakshmi

2016-01-01

Good clinical practice (GCP) guidelines have been the source of improvement in the quality of clinical trials; however, there are limitations to the application of GCP in the conduct of health research beyond industry-sponsored clinical trials. The UNICEF/UNDP/World Bank/WHO Special Program for Research and Training in Tropical Disease is promoting good practice in all health research involving human through the Good Health Research Practice (GHRP) training program initiative. To report the results of piloting the GHRP training program and formulate further steps to harness GHRP for promoting good practices in all health research involving human, particularly in low- and middle-income countries (LMICs). The objective of this training is to impart knowledge and skills for the application of ethical and quality principles to the design, conduct, recording, and reporting of health research involving human participants based on the level of risk, to ensure a fit-for-purpose quality system. This has been formulated into five sequential modules to be delivered in a 4-day course. Four courses have been organized in the pilot phase (2014-2015). The courses have been evaluated and assessed based on course feedback (quantitative and qualitative data) collected during course implementation and qualitative email-based pre- and post-course evaluation. Participants were highly satisfied with the course content and its organization. The relevance and applicability of the course content resulted in positive feedback and an articulated willingness to adapt and disseminate the course. Action points to strengthen the training program have been identified, and showed the imminent need to develop a consensus with a broader range of key stakeholders on the final set of GHRP standards and means for implementation. There is an urgent need to harness the momentum to promote high-quality and ethical health research in LMICs through scaling up GHRP training and further development of GHRP

Good-parent beliefs of parents of seriously ill children.

Science.gov (United States)

Feudtner, Chris; Walter, Jennifer K; Faerber, Jennifer A; Hill, Douglas L; Carroll, Karen W; Mollen, Cynthia J; Miller, Victoria A; Morrison, Wynne E; Munson, David; Kang, Tammy I; Hinds, Pamela S

2015-01-01

Parents' beliefs about what they need to do to be a good parent when their children are seriously ill influence their medical decisions, and better understanding of these beliefs may improve decision support. To assess parents' perceptions regarding the relative importance of 12 good-parent attributes. A cross-sectional, discrete-choice experiment was conducted at a children's hospital. Participants included 200 parents of children with serious illness. Ratings of 12 good-parent attributes, with subsequent use of latent class analysis to identify groups of parents with similar ratings of attributes, and ascertainment of whether membership in a particular group was associated with demographic or clinical characteristics. The highest-ranked good-parent attribute was making sure that my child feels loved, followed by focusing on my child's health, making informed medical care decisions, and advocating for my child with medical staff. We identified 4 groups of parents with similar patterns of good-parent-attribute ratings, which we labeled as: child feels loved (n=68), child's health (n=56), advocacy and informed (n=55), and spiritual well-being (n=21). Compared with the other groups, the child's health group reported more financial difficulties, was less educated, and had a higher proportion of children with new complex, chronic conditions. Parents endorse a broad range of beliefs that represent what they perceive they should do to be a good parent for their seriously ill child. Common patterns of how parents prioritize these attributes exist, suggesting future research to better understand the origins and development of good-parent beliefs among these parents. More important, engaging parents individually regarding what they perceive to be the core duties they must fulfill to be a good parent may enable more customized and effective decision support.

What is a good midwife? Insights from the literature.

Science.gov (United States)

Borrelli, Sara Elisabetta

2014-01-01

to review the literature around what is considered to be a good midwife and in particular what women value in a midwife, in order to identify the gaps in the evidence for future research. this paper reviews the research in the area of interest over the past 30 years. The literature search focused on the concept of good midwife using synonyms and antonyms. The inclusion criteria included language (English or Italian). The examined databases were Medline, Maternity and Infant Care, Applied Social Sciences Index and Abstract and CINAHL. studies conducted in high-income countries were taken into account. A focused review of papers which explicitly investigated what a good midwife means and a thematic analysis on what women value in a midwife were carried out. different standpoints have been considered (midwives, student midwives, women and their partners), focusing in particular on women viewpoint. the literature review reveals information about what is considered to be a good midwife from a range of perspectives and what women value in a midwife. A good midwife should possess several attributes: theoretical knowledge, professional competencies, personal qualities, communication skills and moral/ethical values. According to the thematic analysis around what childbearing women value in a midwife, frequent key-themes emerging from the literature were: support, possibility of choice, feeling in control and having appropriate information. the meaning of good midwife might change according to different actors involved in midwifery care and there is no agreement on the definition of what constitutes a good midwife. Furthermore, it is not clear if what women value in a good midwife corresponds to the midwives' perception of themselves as good professionals. There is a dearth of information around women's expectations and experiences specifically of a good midwife, and even less around whether this changes according to where they give birth. this literature review seeks to

Top 10 metrics for life science software good practices.

Science.gov (United States)

Artaza, Haydee; Chue Hong, Neil; Corpas, Manuel; Corpuz, Angel; Hooft, Rob; Jimenez, Rafael C; Leskošek, Brane; Olivier, Brett G; Stourac, Jan; Svobodová Vařeková, Radka; Van Parys, Thomas; Vaughan, Daniel

2016-01-01

Metrics for assessing adoption of good development practices are a useful way to ensure that software is sustainable, reusable and functional. Sustainability means that the software used today will be available - and continue to be improved and supported - in the future. We report here an initial set of metrics that measure good practices in software development. This initiative differs from previously developed efforts in being a community-driven grassroots approach where experts from different organisations propose good software practices that have reasonable potential to be adopted by the communities they represent. We not only focus our efforts on understanding and prioritising good practices, we assess their feasibility for implementation and publish them here.

Criss-Crossing Globalization : Uphill Flows of Skill-Intensive Goods and Foreign Direct Investment

OpenAIRE

Mattoo, Aaditya; Subramanian, Arvind

2009-01-01

This paper documents an unusual and possibly significant phenomenon: the export of skills, embodied in goods, services or capital from poorer to richer countries. The authors first present a set of stylized facts. Then, using a measure that combines the sophistication of a country s exports with the average income level of destination countries, they show that the performance of a number o...

USSR Report, Consumer Goods and Domestic Trade, No. 40

National Research Council Canada - National Science Library

1982-01-01

The report contains articles on USSR consumer goods production and distribution with particular attention to Food Services, milk processing, textile, household goods production, and motorcycle spare parts...

21 CFR 120.5 - Current good manufacturing practice.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Current good manufacturing practice. 120.5 Section... Provisions § 120.5 Current good manufacturing practice. Part 110 of this chapter applies in determining whether the facilities, methods, practices, and controls used to process juice are safe, and whether the...

21 CFR 129.1 - Current good manufacturing practice.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Current good manufacturing practice. 129.1 Section... Current good manufacturing practice. The applicable criteria in part 110 of this chapter, as well as the..., methods, practices, and controls used in the processing, bottling, holding, and shipping of bottled...

Genetically modified foods as global public goods

Directory of Open Access Journals (Sweden)

Susana Herrero Olarte

2014-07-01

Full Text Available "Genetically modified (GM food has become very important in the field of research, as a result of its expansion in recent decades. As the right to food is a human right, it cannot be left in the hands of private sector developments exclusively, due to the capacity of the public sector to limit or drive it, and in any case, contributing to food safety. To achieve this, and for its cross-border development, GM needs to be treated as Global Public Goods (GPG, defined as pure or impure public goods that cannot be provided or regulated from a national or regional level, but from a global perspective. Its definition as GPG, and the fact of being public goods, assumes greater involvement by the public sector for its supply or regulation. It is therefore necessary to analyze the positive and negative externalities generated by transgenic foods becoming public goods, but from a global perspective. The difficulty is, that according to the author, GMs are positive or negative, so that there is no consensus to restrict and even prevent them or encourage them. But, there is a consensus on some key issues of GM food, such as improving productivity, contributing to the reduction of the species, the dependence of farmers, or monopoly companies with the patent. Identifying these issues can serve to initiate the appropriate regulation."

[Doctor Levi B. Salmans, founder of The Good Samaritan sanitarium in Guanajuato].

Science.gov (United States)

Olivier-Toledo, Carlos; Viesca-Treviño, Carlos

2016-01-01

In this research we focus on the medical evangelist Levi B. Salmans, and The Good Samaritan sanitarium. Doctor Salmans lived in Mexico for about 50 years (1885-1935). During the first part of his stay, he was devoted to found churches and Methodist schools. However, from 1891 he took a turn in his career by founding dispensaries in different towns of Guanajuato to create, in 1899, the private charity association for the sick and infirm The Good Samaritan. His intense, intellectual, and practical work led him to create health journals, to train nurses, and to promote physiotherapies in accordance with the science advances of that time. By itself, this research shows that the history of medicine in Mexico still has long way to go and that Protestant communities, in favor of modernity and scientific knowledge, took a big part in shaping the history of this discipline in Mexico.

21 CFR 113.5 - Current good manufacturing practice.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Current good manufacturing practice. 113.5 Section... CONTAINERS General Provisions § 113.5 Current good manufacturing practice. The criteria in §§ 113.10, 113.40..., methods, practices, and controls used by the commercial processor in the manufacture, processing, or...

Mentoring Graduate Students: The Good, Bad, and Gray

Science.gov (United States)

Ballantine, Jeanne H.; Jolly-Ballantine, John-Andrew

2015-01-01

Good mentoring of graduate students influences their perseverance and success to completion, whereas bad mentoring can result in negative outcomes, including delayed degree completion or non-completion. What the authors refer to as the gray zone is that which falls between good and bad mentoring. Examples are partial mentoring or changes in…

Time perception: the bad news and the good

Science.gov (United States)

Matthews, William J; Meck, Warren H

2014-01-01

Time perception is fundamental and heavily researched, but the field faces a number of obstacles to theoretical progress. In this advanced review, we focus on three pieces of ‘bad news’ for time perception research: temporal perception is highly labile across changes in experimental context and task; there are pronounced individual differences not just in overall performance but in the use of different timing strategies and the effect of key variables; and laboratory studies typically bear little relation to timing in the ‘real world’. We describe recent examples of these issues and in each case offer some ‘good news’ by showing how new research is addressing these challenges to provide rich insights into the neural and information-processing bases of timing and time perception. PMID:25210578

Trees are good, but…

Science.gov (United States)

E.G. McPherson; F. Ferrini

2010-01-01

We know that “trees are good,” and most people believe this to be true. But if this is so, why are so many trees neglected, and so many tree wells empty? An individual’s attitude toward trees may result from their firsthand encounters with specific trees. Understanding how attitudes about trees are shaped, particularly aversion to trees, is critical to the business of...

Optional contributions have positive effects for volunteering public goods games

Science.gov (United States)

Song, Qi-Qing; Li, Zhen-Peng; Fu, Chang-He; Wang, Lai-Sheng

2011-11-01

Public goods (PG) games with the volunteering mechanism are referred to as volunteering public goods (VPG) games, in which loners are introduced to the PG games, and a loner obtains a constant payoff but not participating the game. Considering that small contributions may have positive effects to encourage more players with bounded rationality to contribute, this paper introduces optional contributions (high value or low value) to these typical VPG games-a cooperator can contribute a high or low payoff to the public pools. With the low contribution, the logit dynamics show that cooperation can be promoted in a well mixed population comparing to the typical VPG games, furthermore, as the multiplication factor is greater than a threshold, the average payoff of the population is also enhanced. In spatial VPG games, we introduce a new adjusting mechanism that is an approximation to best response. Some results in agreement with the prediction of the logit dynamics are found. These simulation results reveal that for VPG games the option of low contributions may be a better method to stimulate the growth of cooperation frequency and the average payoff of the population.

Competition of tolerant strategies in the spatial public goods game

Science.gov (United States)

Szolnoki, Attila; Perc, Matjaž

2016-08-01

Tolerance implies enduring trying circumstances with a fair and objective attitude. To determine whether evolutionary advantages might be stemming from diverse levels of tolerance in a population, we study a spatial public goods game, where in addition to cooperators, defectors, and loners, tolerant players are also present. Depending on the number of defectors within a group, a tolerant player can either cooperate in or abstain from a particular instance of the game. We show that the diversity of tolerance can give rise to synergistic effects, wherein players with a different threshold in terms of the tolerated number of defectors in a group compete most effectively against defection and default abstinence. Such synergistic associations can stabilise states of full cooperation where otherwise defection would dominate. We observe complex pattern formation that gives rise to an intricate phase diagram, where invisible yet stable strategy alliances require outmost care lest they are overlooked. Our results highlight the delicate importance of diversity and tolerance for the provisioning of public goods, and they reveal fascinating subtleties of the spatiotemporal dynamics that is due to the competition of subsystem solutions in structured populations.

Create a good learning environment and motivate active learning enthusiasm

Science.gov (United States)

Bi, Weihong; Fu, Guangwei; Fu, Xinghu; Zhang, Baojun; Liu, Qiang; Jin, Wa

2017-08-01

In view of the current poor learning initiative of undergraduates, the idea of creating a good learning environment and motivating active learning enthusiasm is proposed. In practice, the professional tutor is allocated and professional introduction course is opened for college freshman. It can promote communication between the professional teachers and students as early as possible, and guide students to know and devote the professional knowledge by the preconceived form. Practice results show that these solutions can improve the students interest in learning initiative, so that the active learning and self-learning has become a habit in the classroom.

Good Administration as a Fundamental Right

Directory of Open Access Journals (Sweden)

Margrét Vala Kristjánsdóttir

2013-06-01

Full Text Available The EU Charter of Fundamental Rights lists good administration as a fundamental right. The scope of this right, as defined in Article 41 of the EU Charter, is limited to situations in which persons are dealing with the institutions and bodies of the European Union; this gives it a narrower scope than that of the Charter as a whole. This paper discusses the status of this right as a subjective, fundamental right and a codified principle of EU law. The focus is on the question of applicability of the right to situations in which persons are dealing with the institutions and bodies of Member States and questions are raised regarding the implications of Article 41 in this respect. The paper concludes that Article 41 of the Charter in fact limits the applicability of good administration to the institutions and bodies of the EU. This does not however, preclude the applicability of a general principle of good administration, as established by the European Court of Justice, to Member States and the formal recognition of this principle in the EU Charter seems to affect legal reasoning and contribute to some extent to the protection of administrative rules in the implementation of EU law.

GOODS AND SERVICE TAX ONE NATION ONE TAX IN INDIA.

OpenAIRE

Shuchi Sharma; Rupendra Prakash Yadav.

2018-01-01

Goods and Service Tax is a significant and logical step towards a comprehensive Indirect tax reform in India. This paper analyses the concept of Goods Service Tax and further discusses their impact on the various sectors in India. Brief description is given on Goods Service Tax background and Goods and Service Tax models helps to reduce tax burden. It aims at creating a single and unified market benefiting both corporate and economy because this is the only Indirect tax that directly affects ...

What's it all about? What does good economic management mean in Australia

OpenAIRE

Quiggin, John; Junankar, Raja

2013-01-01

This paper considers the question of what is meant by good economic management. In addressing this question it considers both the long term perspective and the international perspective. Australia's post GFC experience is contrasted favourably with a broad range of other countries, especially countries that cut government spending as their economies slowed. As Figure 1 shows Australia's economic performance as measured by GDP has been superior to the rest of the developed world, especially wh...

47 CFR 76.65 - Good faith and exclusive retransmission consent complaints.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 4 2010-10-01 2010-10-01 false Good faith and exclusive retransmission consent... § 76.65 Good faith and exclusive retransmission consent complaints. (a) Duty to negotiate in good faith. Television broadcast stations and multichannel video programming distributors shall negotiate in good faith...

Narrating the Good Life: Illuminations.

Science.gov (United States)

Suoranta, Juha

2000-01-01

The conception of the good life in theoretical texts and adult learners' written narratives depicts well-being in terms of aesthetic experiences, values, existential experiences, autonomy, and significant others. Future prospects for adult education as legislative practice, as therapy and as commitment are derived from the discussion. (SK)

Getting Out the Good News.

Science.gov (United States)

Paciancia, David

1995-01-01

A majority of American schools are meeting the challenge of educating children. A New York State district gets out the good news by producing school newsletters and videos, by constant and close contact with the local news media, and by forming ties with local real estate agents. (MLF)

75 FR 80011 - Good Laboratory Practice for Nonclinical Laboratory Studies

Science.gov (United States)

2010-12-21

.... FDA-2010-N-0548] Good Laboratory Practice for Nonclinical Laboratory Studies AGENCY: Food and Drug... (FDA) is seeking comment on whether to amend the regulations governing good laboratory practices (GLPs..., 1978 (43 FR 60013). As stated in its scope (Sec. 58.1), this regulation prescribes good laboratory...

Microbiological criteria for good manufacturing practice (GMP)

Energy Technology Data Exchange (ETDEWEB)

Farkas, J [Inst. of Preservation and Livestock Products Technology, Univ. of Horticulture and Food Industry, Budapest (Hungary); Zukal, E [Inst. of Preservation and Livestock Products Technology, Univ. of Horticulture and Food Industry, Budapest (Hungary)

1992-01-01

Good manufacturing practice (GMP) consist of an effective manufacturing operation and an effective application of food control. GMP is best supported by the Hazard Analysis Critical Control Point system (HACCP) of the preventive quality assurance, which requires that food irradiation as any food processing technology should be used only with foods of an acceptable quality and adequate handling and storage procedures should precede and follow the processing. The paper concentrates on the first element of the HACCP system for an irradiation plant: the incoming product control, i.e. whether GMP of foods to be irradiated can be assessed by establishing microbiological criteria for their previous good manufacturing practice. In this regard, it summarizes considerations and findings of a ''Consultation on Microbiological Criteria for Foods to be Further Processed Including by Irradiation'' held in 1989 by the International Consultative Group on Food irradiation at the Headquarters of the World Health Organization, Geneva. Difficulties in establishing reference values and defining good manufacturing practices will be pointed out. (orig.)

Microbiological criteria for good manufacturing practice (GMP)

International Nuclear Information System (INIS)

Farkas, J.; Zukal, E.

1992-01-01

Good manufacturing practice (GMP) consist of an effective manufacturing operation and an effective application of food control. GMP is best supported by the Hazard Analysis Critical Control Point system (HACCP) of the preventive quality assurance, which requires that food irradiation as any food processing technology should be used only with foods of an acceptable quality and adequate handling and storage procedures should precede and follow the processing. The paper concentrates on the first element of the HACCP system for an irradiation plant: the incoming product control, i.e. whether GMP of foods to be irradiated can be assessed by establishing microbiological criteria for their previous good manufacturing practice. In this regard, it summarizes considerations and findings of a ''Consultation on Microbiological Criteria for Foods to be Further Processed Including by Irradiation'' held in 1989 by the International Consultative Group on Food irradiation at the Headquarters of the World Health Organization, Geneva. Difficulties in establishing reference values and defining good manufacturing practices will be pointed out. (orig.) [de

'Good-faith efforts' are enough to avoid punitive damages.

Science.gov (United States)

1999-07-23

The U.S. Supreme Court ruled that employers who make "good faith efforts" to comply with Federal civil rights laws cannot be forced to pay punitive damages for their managers' discriminatory conduct. [Name removed], an employee of the American Dental Association, sued her employer when she was passed over for a promotion. [Name removed] alleged sex discrimination under Title VII of the Civil Rights Act. Evidence showed that the employer rewrote a job description to favor a male candidate. To recover punitive damages, an employee must demonstrate that the employer acted with malice or reckless indifference. The Americans with Disabilities Act specifically uses Title VII with regard to discrimination, including its terms for punitive damages.

19 CFR 10.531 - Originating goods.

Science.gov (United States)

2010-04-01

... ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. United States-Singapore Free Trade Agreement... (2) The good otherwise satisfies any applicable regional value content or other requirements...

Good Publication Practice for Communicating Company-Sponsored Medical Research: GPP3.

Science.gov (United States)

Battisti, Wendy P; Wager, Elizabeth; Baltzer, Lise; Bridges, Dan; Cairns, Angela; Carswell, Christopher I; Citrome, Leslie; Gurr, James A; Mooney, LaVerne A; Moore, B Jane; Peña, Teresa; Sanes-Miller, Carol H; Veitch, Keith; Woolley, Karen L; Yarker, Yvonne E

2015-09-15

This updated Good Publication Practice (GPP) guideline, known as GPP3, builds on earlier versions and provides recommendations for individuals and organizations that contribute to the publication of research results sponsored or supported by pharmaceutical, medical device, diagnostics, and biotechnology companies. The recommendations are designed to help individuals and organizations maintain ethical and transparent publication practices and comply with legal and regulatory requirements. These recommendations cover publications in peer-reviewed journals and presentations (oral or poster) at scientific congresses. The International Society for Medical Publication Professionals invited more than 3000 professionals worldwide to apply for a position on the steering committee, or as a reviewer, for this guideline. The GPP2 authors reviewed all applications (n = 241) and assembled an 18-member steering committee that represented 7 countries and a diversity of publication professions and institutions. From the 174 selected reviewers, 94 sent comments on the second draft, which steering committee members incorporated after discussion and consensus. The resulting guideline includes new sections (Principles of Good Publication Practice for Company-Sponsored Medical Research, Data Sharing, Studies That Should Be Published, and Plagiarism), expands guidance on the International Committee of Medical Journal Editors' authorship criteria and common authorship issues, improves clarity on appropriate author payment and reimbursement, and expands information on the role of medical writers. By following good publication practices (including GPP3), individuals and organizations will show integrity; accountability; and responsibility for accurate, complete, and transparent reporting in their publications and presentations.

Quantifying capital goods for collection and transport of waste.

Science.gov (United States)

Brogaard, Line K; Christensen, Thomas H

2012-12-01

The capital goods for collection and transport of waste were quantified for different types of containers (plastic containers, cubes and steel containers) and an 18-tonnes compacting collection truck. The data were collected from producers and vendors of the bins and the truck. The service lifetime and the capacity of the goods were also assessed. Environmental impact assessment of the production of the capital goods revealed that, per tonne of waste handled, the truck had the largest contribution followed by the steel container. Large high density polyethylene (HDPE) containers had the lowest impact per tonne of waste handled. The impact of producing the capital goods for waste collection and transport cannot be neglected as the capital goods dominate (>85%) the categories human-toxicity (non-cancer and cancer), ecotoxicity, resource depletion and aquatic eutrophication, but also play a role (>13%) within the other impact categories when compared with the impacts from combustion of fuels for the collection and transport of the waste, when a transport distance of 25 km was assumed.

Identifying Characteristics of a "Good School" in the British and Saudi Arabian Education Systems

Science.gov (United States)

Alzahrani, Saeed Musaid H.; Hammersley-Fletcher, Linda; Bright, Geoff

2016-01-01

This study aims at establishing whether primary schools in the Saudi education system conform to the characteristics of what are referred to as "good schools" in the British education system. The findings established through this study show that only 43.75% of primary schools in Saudi conform to the characteristics of what are referred…

Are Geography Students Good "Environmental Citizens?" A Comparison between Year of Study and over Time

Science.gov (United States)

Robinson, Zoe P.

2015-01-01

Are geography students good "environmental citizens?" Has this improved over time with increasing emphasis on sustainability within higher education? This paper compares environmental attitudes and behaviours of geography students at different stages of their degree and over a seven-year period. The findings show that although geography…

Learn good from bad: Effects of good and bad neighbors in spatial prisoners' dilemma games

Science.gov (United States)

Lu, Peng

2015-10-01

Cooperation is vital for the human society and this study focuses on how to promote cooperation. In our stratification model, there exist three classes: two minorities are elites who are prone to cooperate and scoundrels who are born to defect; one majority is the class of common people. Agents of these three classes interact with each other on a square lattice. Commons' cooperation and its factors are investigated. Contradicting our common sense, it indicates that elites play a negative role while scoundrels play a positive one in promoting commons' cooperation. Besides, effects of good and bad neighbors vary with temptation. When the temptation is smaller the positive effect is able to overcome the negative effect, but the later prevails when the temptation is larger. It concludes that common people are more prone to cooperate in harsh environment with bad neighbors, and a better environment with good neighbors merely leads to laziness and free riding of commons.

Good teaching is good teaching: A narrative review for effective medical educators.

Science.gov (United States)

Berman, Anthony C

2015-01-01

Educators have tried for many years to define teaching and effective teachers. More specifically, medical educators have tried to define what characteristics are common to successful teachers in the healthcare arena. The goal of teacher educators has long been to determine what makes an effective teacher so that they could do a better job of preparing future teachers to have a positive impact on the learning of their students. Medical educators have explored what makes some of their colleagues more able than others to facilitate the development of healthcare professionals who can successfully and safely meet the needs of future patients. Although there has historically been disagreement regarding the characteristics that need be developed in order for teachers to be effective, educational theorists have consistently agreed that becoming an effective teacher is a complex task. Such discussions have been central to deciding what education at any level is really all about. By exploring the literature and reflecting upon the personal experiences encountered in his lengthy career as a teacher, and as a teacher of teachers, the author reaches the conclusions that teaching is both art and science, that "good teaching is good teaching" regardless of the learning environment or the subject to be explored, and that the characteristics making up an effective medical educator are really not much different than those making up effective educators in any other area. © 2015 American Association of Anatomists.

Piracy and Product Differentiation in the Market of Digital Goods

OpenAIRE

Alvisi Matteo; Argentesi Elena; Carbonara Emanuela

2003-01-01

We analyse how piracy affects the choice of quality of a monopolist producing a digital good. A digital good is a special kind of information good, for example a music CD, a DVD or an electronic magazine available online. An important feature of digital goods is that they can be copied without a decline in the copy's quality. We define piracy as both the production and the sale of illegal copies and the practice of file sharing through the Internet. Recently, the introduction of fast Internet...

When good news leads to bad choices.

Science.gov (United States)

McDevitt, Margaret A; Dunn, Roger M; Spetch, Marcia L; Ludvig, Elliot A

2016-01-01

Pigeons and other animals sometimes deviate from optimal choice behavior when given informative signals for delayed outcomes. For example, when pigeons are given a choice between an alternative that always leads to food after a delay and an alternative that leads to food only half of the time after a delay, preference changes dramatically depending on whether the stimuli during the delays are correlated with (signal) the outcomes or not. With signaled outcomes, pigeons show a much greater preference for the suboptimal alternative than with unsignaled outcomes. Key variables and research findings related to this phenomenon are reviewed, including the effects of durations of the choice and delay periods, probability of reinforcement, and gaps in the signal. We interpret the available evidence as reflecting a preference induced by signals for good news in a context of uncertainty. Other explanations are briefly summarized and compared. © 2016 Society for the Experimental Analysis of Behavior.

21 CFR 114.5 - Current good manufacturing practice.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Current good manufacturing practice. 114.5 Section...) FOOD FOR HUMAN CONSUMPTION ACIDIFIED FOODS General Provisions § 114.5 Current good manufacturing practice. The criteria in §§ 114.10, 114.80, 114.83, 114.89, and 114.100, as well as the criteria in part...

Educating for Good Work: From Research to Practice

Science.gov (United States)

Mucinskas, Daniel; Gardner, Howard

2013-01-01

Launched in 1995, the GoodWork Project is a long-term, multi-site effort to understand the nature of good work across the professional landscape and to promote its achievement by relevant groups of students and professionals. In this essay, the authors review the goals and methods of the initial research project and its most salient findings. They…

Teachers' and Students' Conceptions of Good Science Teaching

Science.gov (United States)

Yung, Benny Hin Wai; Zhu, Yan; Wong, Siu Ling; Cheng, Man Wai; Lo, Fei Yin

2013-01-01

Capitalizing on the comments made by teachers on videos of exemplary science teaching, a video-based survey instrument on the topic of "Density" was developed and used to investigate the conceptions of good science teaching held by 110 teachers and 4,024 year 7 students in Hong Kong. Six dimensions of good science teaching are identified…

19 CFR 10.451 - Originating goods.

Science.gov (United States)

2010-04-01

... ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. United States-Chile Free Trade Agreement Rules... good otherwise satisfies any applicable regional value content or other requirements specified in...

Income inequality and status seeking: searching for positional goods in unequal U.S. States.

Science.gov (United States)

Walasek, Lukasz; Brown, Gordon D A

2015-04-01

It is well established that income inequality is associated with lower societal well-being, but the psychosocial causes of this relationship are poorly understood. A social-rank hypothesis predicts that members of unequal societies are likely to devote more of their resources to status-seeking behaviors such as acquiring positional goods. We used Google Correlate to find search terms that correlated with our measure of income inequality, and we controlled for income and other socioeconomic factors. We found that of the 40 search terms used more frequently in states with greater income inequality, more than 70% were classified as referring to status goods (e.g., designer brands, expensive jewelry, and luxury clothing). In contrast, 0% of the 40 search terms used more frequently in states with less income inequality were classified as referring to status goods. Finally, we showed how residual-based analysis offers a new methodology for using Google Correlate to provide insights into societal attitudes and motivations while avoiding confounds and high risks of spurious correlations. © The Author(s) 2015.

Codes of Good Governance

DEFF Research Database (Denmark)

Beck Jørgensen, Torben; Sørensen, Ditte-Lene

2013-01-01

Good governance is a broad concept used by many international organizations to spell out how states or countries should be governed. Definitions vary, but there is a clear core of common public values, such as transparency, accountability, effectiveness, and the rule of law. It is quite likely......, transparency, neutrality, impartiality, effectiveness, accountability, and legality. The normative context of public administration, as expressed in codes, seems to ignore the New Public Management and Reinventing Government reform movements....

Information About Cost of Goods Produced and its Usefulness for Production Engineers - A Case of SME

Science.gov (United States)

Maruszewska, Ewa Wanda; Strojek-Filus, Marzena; Drábková, Zita

2017-12-01

The article stresses the consequences of simplifications implemented in the measurement process of goods produced that are of crucial importance to production engineers in SME. The authors show the variety of possibilities that might be used by financial employees together with probable outputs in terms of valuation distortions. Using the case study the authors emphasis the importance of close cooperation of production engineers with finance professionals as out-puts of finance departments consist an important input for decision-making process of production managers. Further-more, demonstrated deficiencies in terms of methods applicable in financial reporting for measurement of the value of goods produced indicate the need for incorporation more financial and non-financial data in the process of judgments about the final cost of goods produced as simplifications applied in SME distort financial information provided to production engineers.

49 CFR 375.409 - May household goods brokers provide estimates?

Science.gov (United States)

2010-10-01

... 49 Transportation 5 2010-10-01 2010-10-01 false May household goods brokers provide estimates? 375... Estimating Charges § 375.409 May household goods brokers provide estimates? A household goods broker must not... there is a written agreement between the broker and you, the carrier, adopting the broker's estimate as...

Good Governance and Successful Development: Cross Countries Investigation

Directory of Open Access Journals (Sweden)

Tabthip Kraipornsak

2014-05-01

Full Text Available Good Governance is one of the essential factors of success in business as well as in a country’s development. This study aimed at examining the role of good governance and the success of the development. The comparable per head GDP measured in PPP (purchasing power parity was used as the proxy of the successful economic development of countries in the study. Four out of total six factors (indicators being the good governance and the other two being social environmental factors were employed in the investigation following concept of the role of external business environmental factors so called “PESTLE or Political, Economic, Social, Technological, Legislative or Legal, and Eco-environmental analysis”. These four indicators of good governance are political stability, control of corruption, rule of law, and voice and accountability which are available from the World Bank’s governance project data base. In addition, the other two indicators, country’s openness and size of population, are the major social variables included in the study which can also affect the success. The total six indicators are taken to examine with the GDP per head to see whether these factors can help countries achieve higher levels of income per head. The study indicates connection between the levels of success with these four indicators of the good governance and the two external social variables. For Thailand, the political instability was found to be a problem of the progress of development among those six indicators.

20 CFR 416.1216 - Exclusion of household goods and personal effects.

Science.gov (United States)

2010-04-01

... value or as an investment because we do not consider these to be personal effects. Such items can... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Exclusion of household goods and personal... household goods and personal effects. (a) Household goods. (1) We do not count household goods as a resource...

Mobility as a positional good : implications for transport policy and planning

Energy Technology Data Exchange (ETDEWEB)

Litman, T. [Victoria Transport Policy Institute, Victoria, BC (Canada)

2007-01-17

Social position refers to a person's social rank. Many goods have positional value because they increase the status of their consumers. Positional goods include fashionable jewellery and clothing, luxurious homes and vehicles, and extravagant entertainment. Many motorists choose vehicles with greater potential speeds and off-road abilities than actually needed because these features are considered prestigious. This paper examined how positional value affects transportation decisions and investigated the resulting economic impacts. These included impacts on social welfare and external costs. The paper also discussed implications for transport policy and planning. The paper discussed the science of happiness and included an excerpt from a newspaper article on money and happiness. The paper also included an analysis of popular television shows and Internet blogs. Transportation impacts were also examined, with reference to motor vehicle ownership, luxury vehicles, mode choice, long-distance recreation travel, planning practices, and industrial development policy. A table was also presented that summarized the categories of prestige value travel impacts. The paper also presented possible offsetting benefits and implications for planning. 40 refs., 1 tab., 11 figs.

Coupled Oscillator Model of the Business Cycle withFluctuating Goods Markets

Science.gov (United States)

Ikeda, Y.; Aoyama, H.; Fujiwara, Y.; Iyetomi, H.; Ogimoto, K.; Souma, W.; Yoshikawa, H.

The sectoral synchronization observed for the Japanese business cycle in the Indices of Industrial Production data is an example of synchronization. The stability of this synchronization under a shock, e.g., fluctuation of supply or demand, is a matter of interest in physics and economics. We consider an economic system made up of industry sectors and goods markets in order to analyze the sectoral synchronization observed for the Japanese business cycle. A coupled oscillator model that exhibits synchronization is developed based on the Kuramoto model with inertia by adding goods markets, and analytic solutions of the stationary state and the coupling strength are obtained. We simulate the effects on synchronization of a sectoral shock for systems with different price elasticities and the coupling strengths. Synchronization is reproduced as an equilibrium solution in a nearest neighbor graph. Analysis of the order parameters shows that the synchronization is stable for a finite elasticity, whereas the synchronization is broken and the oscillators behave like a giant oscillator with a certain frequency additional to the common frequency for zero elasticity.

On the evaluation of cultural and environmental public goods, and its implications for social innovation.

Science.gov (United States)

Graffeo, Michele; Bonini, Nicolao

2013-01-01

Public goods (e.g., parks) and welfare services (e.g., garbage disposal and transportation policies) are extremely important for the citizens' well-being but in the complex modern societies their influence and effectiveness are affected by the citizens' support. For this reason, it is crucial to understand which are the factors that influence the citizens' perception of the benefits, costs, and risks associated to public goods and welfare services. In this chapter, we describe some psychological variables that are relevant for the evaluation process of the public goods, but that are not considered by the standard economic models. At the same time, we show that some variables of central importance for the economic models do not significantly affect the citizens' evaluations. Finally, we discuss the concept of Nudge, a policy-making approach that suggests the use of psychological mechanisms to increase the citizens' support to public provision of welfare services. Copyright © 2013 Elsevier B.V. All rights reserved.

The merchant shipping (dangerous goods) (amendment) rules 1980 No. 789

International Nuclear Information System (INIS)

1980-01-01

These Rules amend the Merchant Shipping Rules 1978 and revoke the Merchant Shipping (Dangerous Goods) (Amendment) Rules 1979. The purpose of this amendment is to update the references to the 1978 Report of the Department of Trade's Standing Advisory Committee on the Carriage of Dangerous Goods in Ships (the Blue Book) and the 1977 Edition of the International Maritime Dangerous Goods Code of IMCO (the IMDG Code), referred to in the 1978 Rules. The amendments concern, inter alia, marking of packages on board ship which contain dangerous goods, including radioactive materials (NEA) [fr

Good practice achievement of the firms within National agro processing industry of Thailand: Impacts on corporate image and stakeholder acceptance

Directory of Open Access Journals (Sweden)

Nuttavong Poonpool

2016-07-01

Full Text Available This article is about the effects of good practice achievement on stakeholder acceptance. The study examines the relationship between good practice achievement and stakeholder acceptance, where corporate image is taken as a mediator. The samples were 486 chief executive officers (CEO who participated in the national agro processing industry of Thailand. The ordinary least squares (OLS regression analysis was employed for data analysis. The findings show that good practice achievement, in which consists of fairness, transparency, accountability, responsibility, consistency, and independent, have the positive effect on corporate image significantly (p<0.1. Interestingly, corporate image mediates the relationship between good practice achievement and stakeholder acceptance significantly (p<0.05. Therefore, a key decision for managers in all levels and functions is to focus on good practice achievement that improves and develops corporate image and boost stakeholder acceptance.

Factors affecting workers' delivery of good hygienic and sanitary ...

African Journals Online (AJOL)

ADEYEYE

2015-03-06

Mar 6, 2015 ... adhere to Good Manufacturing Practices (GMP) and. Good Hygiene Practices ... has resulted in meat contamination and poor waste disposal, with ... and other food animals arrive these slaughterhouses from various parts of ...

What determines good recovery in patients with the most severe strokes?

DEFF Research Database (Denmark)

Jørgensen, H S; Reith, J; Nakayama, H

1999-01-01

Even patients with the most severe strokes sometimes experience a remarkably good recovery. We evaluated possible predictors of a good outcome to search for new therapeutic strategies.......Even patients with the most severe strokes sometimes experience a remarkably good recovery. We evaluated possible predictors of a good outcome to search for new therapeutic strategies....

Mothers' Appraisal of Goodness of Fit and Children's Social Development

Science.gov (United States)

Seifer, Ronald; Dickstein, Susan; Parade, Stephanie; Hayden, Lisa C.; Magee, Karin Dodge; Schiller, Masha

2014-01-01

Goodness of fit has been a key theoretical construct for understanding caregiver-child relationships. We developed an interview method to assess goodness of fit as a relationship construct, and employed this method in a longitudinal study of child temperament, family context, and attachment relationship formation. Goodness of fit at 4 and 8 months…

Communication from Goods Reception services

CERN Multimedia

2007-01-01

Members of the personnel are invited to take note that only parcels corresponding to official orders or contracts will be handled at CERN. Individuals are not authorised to have private merchandise delivered to them at CERN and private deliveries will not be accepted by the Goods Reception services. Thank you for your understanding.

Karakteristik Sosial Ekonomi Petani Miskin dalam Pengelolaan Usaha Mikro "Tourism Souvenir Goods"

Directory of Open Access Journals (Sweden)

Dumasari Dumasari

2013-12-01

Full Text Available This article aims to consider  the socio economic characteristics of poor peasants and profile of micro enterprises tourism souvenir goods made from agricultural waste which is managed in the countryside. The research takes place in the rural of Baturaden and  Cilongok Tourism Area, Banyumas Regency, Central Java Province. The research method was a descriptive case study with a qualitative and quantitative approach.  The research results revealed that poor peasant have certain socio economic characteristics in managing their micro enterprises tourism souvenir goods in the rural of Baturaden and the Cilongok Tourism Area. These certain criterias are they have the power to encourage and motivate potential influence and spirit  in managing their micro enterprises. The profile of micro enterprises shows the similarities and differences in indicators observed.  Poor peasant need some  real efforts to increase self reliance and entrepreneurship  skills in the development of their own micro enterpreses at rural area.

The Effects of the International Contract for Sale of Goods

Directory of Open Access Journals (Sweden)

Berlingher Daniel

2017-06-01

Full Text Available The contracts are the indispensable legal instruments for any economic transaction. The international sale contract is the main legal instrument by which international commerce is carried out and through which the movement of goods from producer to consumer is ensured within cross-border relations. The sale contract in international commerce is the legal act by which the parties, the seller and the buyer, belonging to different states, commit each other to transfer the property of a good in return for payment of a price. Regarding the general rules applicable to the contract of international sale of goods, they are regulated by the “United Nations Convention on Contracts for the International Sale of Goods from Vienna”. The Convention has adopted uniform rules to govern the international sale of goods contract, if the parties have not chosen expressly for the application of other rules. In this study I present the effects of international sale of goods in the light of the rules of the Vienna Convention of 1980.

Study on the Chinese Goods Market Structure and Related Integrated Marketing Strategy

OpenAIRE

Qishen Zhou; Mingxing Yang

2013-01-01

This study aims to investigate the Chinese goods market structure and related integrated marketing strategy. In recent years, it is becoming more and more popular for Chinese consumers to go on luxury consuming in a variety of large cities in China, showing the increasing demand of luxury for Chinese people possessed relatively high fortune. Further, dozens of international famous luxury brands are pouring into the Chinese market such as LVMH and Gucci, recognizing the huge consumption demand...

Good Design is Good Social Change: Envisioning an Age of Accountability in Communication Design Education

Science.gov (United States)

Bennett, Audrey

2012-01-01

Using typography as its exemplar with its lack of clear performance criteria, this article questions what is good design and how to measure a designer's accountability. Evaluation criteria are teased out from various perspectives: credibility, ease of use, stakeholder inclusion in the design process, respect for cultural dimensions and whether it…

Skin Diseases: Skin and Sun—Not a good mix

Science.gov (United States)

Skip Navigation Bar Home Current Issue Past Issues Skin Diseases Skin and Sun —Not a good mix Past Issues / ... of this page please turn Javascript on. Good skin care begins with sun safety. Whether it is ...

HONESTY AND GOOD PRACTICE IN SCIENTIFIC RESEARCH

Directory of Open Access Journals (Sweden)

Jože Trontelj

2008-01-01

Full Text Available In the field of science, we see cases of misconduct ranging from relatively minor departurefrom good manners and practice to more severe dishonesty and even criminal behaviour.Unethical experiments on human beings are among the worst abuses in scientific researchin medicine. Unethical research is usually also worthless from the scientific point of view.The commonest types of offence, however, include mismanagement of data, conscious misinterpretation,wrongful authorship, biased citation of work by others, plagiarism, misquotationor suppression of findings for the interests or upon the request of the sponsor or In the field of science, we see cases of misconduct ranging from relatively minor departurefrom good manners and practice to more severe dishonesty and even criminal behaviour.Unethical experiments on human beings are among the worst abuses in scientific researchin medicine. Unethical research is usually also worthless from the scientific point of view.The commonest types of offence, however, include mismanagement of data, conscious misinterpretation,wrongful authorship, biased citation of work by others, plagiarism, misquotationor suppression of findings for the interests or upon the request of the sponsor or In the field of science, we see cases of misconduct ranging from relatively minor departurefrom good manners and practice to more severe dishonesty and even criminal behaviour.Unethical experiments on human beings are among the worst abuses in scientific researchin medicine. Unethical research is usually also worthless from the scientific point of view.The commonest types of offence, however, include mismanagement of data, conscious misinterpretation,wrongful authorship, biased citation of work by others, plagiarism, misquotationor suppression of findings for the interests or upon the request of the sponsor or even a senior scientist in the team. Every case of misconduct and fraud may causedamage: it may undermine confidence of the

"Good Passengers and Not Good Passengers:" Adolescent Drivers' Perceptions About Inattention and Peer Passengers.

Science.gov (United States)

McDonald, Catherine C; Sommers, Marilyn S

The purpose of this qualitative focus group elicitation research study was to explore teen driver perceptions of peer passengers and driver inattention. We utilized focus groups for data collection and content analysis to analyze the data, both of which were guided by the theory of planned behavior. We conducted 7 focus groups with 30 teens, ages 16-18, licensed for ≤1year to examine attitudes, perceived behavioral control, and norms related to driving inattention and peer passengers. The sample was 50% male, mean age 17.39 (SD 0.52) with mean length of licensure 173.7days (SD 109.2). Three themes emerged: 1) "Good and not good" passengers; 2) Passengers and technology as harmful and helpful; and 3) The driver is in charge. While passengers can be a source of distraction, our participants also identified passenger behaviors that reduced risk, such as assistance with technology and guidance for directions. An understanding of teens' perceptions of peer passengers can contribute to the development of effective interventions targeting teen driver inattention. Nurses are well-positioned to contribute to these teen crash prevention efforts. Copyright © 2016 Elsevier Inc. All rights reserved.

Volunteering as Red Queen mechanism for cooperation in public goods games

DEFF Research Database (Denmark)

Hauert, C.; De Monte, Silvia; Hofbauer, J.

2002-01-01

The evolution of cooperation among nonrelated individuals is one of the fundamental problems in biology and social sciences. Reciprocal altruism fails to provide a solution if interactions are not repeated often enough or groups are too large. Punishment and reward can be very effective but require...... that defectors can be traced and identified. Here we present a simple but effective mechanism operating under full anonymity. Optional participation can foil exploiters and overcome the social dilemma. In voluntary public goods interactions, cooperators and defectors will coexist. We show that this result holds...

Why shared decision making is not good enough: lessons from patients.

Science.gov (United States)

Olthuis, Gert; Leget, Carlo; Grypdonck, Mieke

2014-07-01

A closer look at the lived illness experiences of medical professionals themselves shows that shared decision making is in need of a logic of care. This paper underlines that medical decision making inevitably takes place in a messy and uncertain context in which sharing responsibilities may impose a considerable burden on patients. A better understanding of patients' lived experiences enables healthcare professionals to attune to what individual patients deem important in their lives.This will contribute to making medical decisions in a good and caring manner, taking into account the lived experience of being ill.

Intra-articular injection in patients with juvenile idiopathic arthritis: factors associated with a good response

Directory of Open Access Journals (Sweden)

Ana Luiza Garcia Cunha

Full Text Available ABSTRACT Introduction: Intra-articular injection of corticosteroids (IIC for treatment of patients with juvenile idiopathic arthritis (JIA is increasingly used in Pediatric Rheumatology. Objectives: To describe the clinical course of patients undergoing IIC in our Pediatric Rheumatology Unit. Methods: Retrospective study of patients with JIA undergoing IIC from January 2008 to December 2012, with a minimum follow-up of six months after the injection. Good response to IIC was set as the presence of inactivity on the infiltrated joint by at least six months. Results: Eighty-eight patients underwent a total of 165 IICs. Of these, 75% were girls and 35.2% had persistent oligoarticular JIA. The mean age at diagnosis was 6.8 years, and when IIC was carried out, 12.2 years. Regarding patients, younger age at diagnosis (p = 0.037 and the occurrence of uveitis in the course of the disease (p = 0.015 were associated with good response to IIC. From 165 IICs, 63% had a good response and joints remained inactive for a median of 18.1 months. The type of joint injection (p = 0.001, lesser values stated in the overall visual analog scale by the physician (p = 0.015 and by parents/patient (p = 0.01 have been associated with a good response to IIC. Nine adverse events (5.4% were observed. Conclusion: In our study, more than half of the joints showed a good response to IIC. Younger patients at diagnosis and uveitis during the course of the disease had good response to IIC. Knees, wrists and elbows were the joints that best responded to IIC. IIC proved to be a safe procedure.

Gender Play and Good Governance

Science.gov (United States)

Powell, Mark

2008-01-01

Like good government, thoughtful care of children requires those in power, whether teachers or parents, to recognize when it is appropriate for them to step back from day-to-day decision-making while still working behind the scenes to ensure an organizational structure that supports the independence and equitable development of those they serve.…

Making the Common Good Common

Science.gov (United States)

Chase, Barbara

2011-01-01

How are independent schools to be useful to the wider world? Beyond their common commitment to educate their students for meaningful lives in service of the greater good, can they educate a broader constituency and, thus, share their resources and skills more broadly? Their answers to this question will be shaped by their independence. Any…

Entrepreneurs' self-reported health, social life, and strategies for maintaining good health.

Science.gov (United States)

Gunnarsson, Kristina; Josephson, Malin

2011-01-01

This study investigated the association between self-reported good health and self-valued good social life. An additional aim was to examine entrepreneur's strategies for maintaining good health. The study design included a two-wave questionnaire, with five years between the surveys (2001 and 2006), and qualitative interviews. The study group consisted of 246 entrepreneurs from the central region of Sweden and represented ten different trades. Entrepreneurs reporting good health in both 2001 and 2006 were compared with entrepreneurs reporting poor health on both occasions or with inconsistent answers. Six of the entrepreneurs were strategically chosen for the interview study. Consistent good health was reported by 56% of the entrepreneurs. Good social life in 2001 was associated with an increased odds ratio (OR) for consistent good health when the analyses were adjusted for physical work conditions and job satisfaction (OR 2.12, 95% CI 1.07-4.17). Findings for good leisure time, weekly moderate physical exercise, and a rating of work being less or equally important as other life areas, were similar but not statistically significant when job satisfaction was considered in the analyses. Strategies for maintaining good health included good planning and control over work, flexibility at work, good social contact with family, friends and other entrepreneurs, and regular physical exercise. This study demonstrated an association between self-reported good health and good social life for entrepreneurs in small-scale enterprises. In addition, the entrepreneurs emphasised strategies such as planning and control over work and physical exercise are important for maintaining good health.

From waste to intelligence: the good use of electricity

International Nuclear Information System (INIS)

2010-01-01

While presenting and commenting many data tables and graphs, this study gives an overview of electricity production and of its good use (production, transport, production and distribution management, uses, sector-based consumption, consumption prospective studies in France for the past 15 years, good use criteria, electricity CO 2 content assessments and objectives). It comments the challenges and sector-based perspectives of an electricity good use by 2020 (in the industry, transport, agriculture, housing and tertiary, and building sectors) and emphasizes, for each sector, some recent assessments or policy choices (national plans adopted within the frame of the 'Grenelle de l'Environnement'). The next part describes and comments how electricity is treated within the energy efficiency European policies with different directives. The last part describes some examples of good practices and comments the various challenges to be met by 2020

Good practices for outage management in nuclear power plants

International Nuclear Information System (INIS)

1991-09-01

As a follow-up to an earlier Technical Document on Good Practices for Improved Nuclear Power Plant Performance (IAEA-TECDOC-498), the Agency has produced a more focused technical report on good practices associated with nuclear power plant outage planning and execution. As with the earlier document, the overall aim is that by identifying good practices in the key aspects of outage management, overall world nuclear performance will improve and the gap between excellent performers and operators with developing programmes will be narrowed. This document has been produced through the contribution of numerous operators and government agencies. It aims at minimizing text and focusing on actual good practices in use which can be found in the annexes. While the specific methods used to achieve excellence in maintenance/refuelling outages may differ, the fundamental requirements of outage management are discussed

WISE MORALS FOR GOOD LIVING

Directory of Open Access Journals (Sweden)

Kiril TEMKOV

2005-12-01

Full Text Available A good book will certainly attract attention of educators and those interested in regular life knowledge. Marija Ajdinska and Velichko Andreevski, well - known pedagogues and special educators, collected thousands of edifying sayings from all over the world and published them as a necessary work for those who think of themselves and others and of life itself. This collection of morals on 300 pages can certainly direct one on the right life path.The morals are divided in 10 chapters – for man and life, woman and love, work and success, good and evil, happiness and hope, freedom and peace, health and age, humanity and friendship, joy and trouble. For each issue there are important considerations and morals, everyone can find a guide for his/her behaviour. Here is one of the morals: “A practical person considers everything in life seriously, but not tragically.”This book of wisdoms reminds us of education and development for everyone. A man was born as a human being that could survive only with the help of other people and learning.

Quantifying capital goods for collection and transport of waste

DEFF Research Database (Denmark)

Brogaard, Line Kai-Sørensen; Christensen, Thomas Højlund

2012-01-01

he capital goods for collection and transport of waste were quantified for different types of containers (plastic containers, cubes and steel containers) and an 18-tonnes compacting collection truck. The data were collected from producers and vendors of the bins and the truck. The service lifetime...... tonne of waste handled. The impact of producing the capital goods for waste collection and transport cannot be neglected as the capital goods dominate (>85%) the categories human-toxicity (non-cancer and cancer), ecotoxicity, resource depletion and aquatic eutrophication, but also play a role (>13...

What is a good Toothbrush, erm, Password?

CERN Multimedia

Computer Security Team

2011-01-01

Do you remember the answer to the question posed in the previous issue of the Bulletin? "Your password should be treated like a toothbrush: do not share it and change it regularly!" After our last article, we received a series of questions on how to choose a good password and remember it easily… Thus, here we go.   A good password is: • private: used and known by one person only; • secret: it does not appear in clear text in any file or program or on a piece of paper pinned to the monitor; • easily remembered: so there is no need to write it down; • at least 8 characters long with a mixture of at least 3 of the following: upper case letters, lower case letters, digits and symbols; • not to be found in a dictionary of any major language nor guessable by any program in a reasonable time.   Here are some hints to help you choose good passwords: • Choose a line o...

Microbiological criteria for good manufacturing practice (GMP)

Energy Technology Data Exchange (ETDEWEB)

Farkas, J. (Inst. of Preservation and Livestock Products Technology, Univ. of Horticulture and Food Industry, Budapest (Hungary)); Zukal, E. (Inst. of Preservation and Livestock Products Technology, Univ. of Horticulture and Food Industry, Budapest (Hungary))

1992-01-01

Good manufacturing practice (GMP) consist of an effective manufacturing operation and an effective application of food control. GMP is best supported by the Hazard Analysis Critical Control Point system (HACCP) of the preventive quality assurance, which requires that food irradiation as any food processing technology should be used only with foods of an acceptable quality and adequate handling and storage procedures should precede and follow the processing. The paper concentrates on the first element of the HACCP system for an irradiation plant: the incoming product control, i.e. whether GMP of foods to be irradiated can be assessed by establishing microbiological criteria for their previous good manufacturing practice. In this regard, it summarizes considerations and findings of a ''Consultation on Microbiological Criteria for Foods to be Further Processed Including by Irradiation'' held in 1989 by the International Consultative Group on Food irradiation at the Headquarters of the World Health Organization, Geneva. Difficulties in establishing reference values and defining good manufacturing practices will be pointed out. (orig.)

Good Health Is a Global Issue

Science.gov (United States)

... live longer and adopt a more western life style? Dr. Glass: The good news is that—with ... through Fogarty's programs have gone on to assume leadership positions in their home countries. Our vision is ...

Show me the goods: The warranting effect of user-generated photographs in online auctions

NARCIS (Netherlands)

Johnson, B.K.; Vang, M.H.; van der Heide, B.

2015-01-01

Consumers using online auction websites face the challenge of appraising products at a distance. Sellers and buyers in online auctions navigate this challenge by displaying and evaluating various cues, a critical one being use of photographs. Warranting theory predicts that cues less subject to

Good Grubbin': Impact of a TV Cooking Show for College Students Living off Campus

Science.gov (United States)

Clifford, Dawn; Anderson, Jennifer; Auld, Garry; Champ, Joseph

2009-01-01

Objective: To determine if a series of 4 15-minute, theory-driven (Social Cognitive Theory) cooking programs aimed at college students living off campus improved cooking self-efficacy, knowledge, attitudes, and behaviors regarding fruit and vegetable intake. Design: A randomized controlled trial with pre-, post- and follow-up tests. Setting:…

Producers' approaches about good agricultural practices in Manisa and İzmir

Directory of Open Access Journals (Sweden)

Karabat Selcuk

2017-01-01

Full Text Available This study includes the agricultural enterprises which apply and do not apply good agricultural practices in Manisa and İzmir provinces. The basic purposes of this research are; to make a comparison between the enterprises apply and do not apply good agricultural practices, to determine the awareness of the producers to good agricultural practices, to specify the tendency of the farmers towards good agricultural practices and to present the factors affecting to good agriculture. In the scope of the study, 25 grape producers in Manisa and 20 mandarin producers in Izmir that apply good agricultural practices have been participated in a survey. Besides, the same survey was also conducted with the same number of producers which do not apply good agricultural practices. To analyze the data, simple calculations such as average, percentage, frequency and through the use of the crosstabs were used and the social-economic status of the producers and some technical and economical specifications of the enterprises were determined. The tendency of the producers towards performing good agricultural practices and the factors affecting to these tendencies have been observed. The tendency of the producers were determined by using Logit Regression Analysis.

GoodWork after 15 Years

DEFF Research Database (Denmark)

Knoop, Hans Henrik

2010-01-01

Hans Henrik Knoop explores ways in which the core ideas of the GoodWork theoretical framework can be related to ongoing issues of import. In particular, he analyzes the ways in which democratic values are at risk when conditions of alignment do not obtain-for example, when the state explicitly...... that are crucial to a democratic polity....

The concept of good faith

NARCIS (Netherlands)

Hesselink, M.W.; Hartkamp, A.S.; Hesselink, M.W.; Hondius, E.H.; Mak, C.; du Perron, C.E.

2011-01-01

If the role of the judge as a creator of rules is fully recognised, there is no need for a general good faith clause in a code or restatement of European private law. It may even do harm because it gives the courts an excuse for not formulating the rule which they apply. If, however, there is still

Multilateral trade liberalization and public goods provision in a North-South trade model with nonhomothetic preferences

OpenAIRE

Stibora, J.J.; Vaal, A. de

2012-01-01

Under nonhomothetic preferences developing countries are less likely to gain from multilateral trade liberalization than developed countries. This paper shows that this relative disadvantage for developing countries changes when the effects on public good provision are taken into account. The impact it has depends on the strength of their comparative advantage in export markets. We show that a strong (weak) comparative advantage in export markets mitigates (reinforces) the relative disadvanta...

Corporate social investment – good business and good revenue: The case of woolworths holdings ltd South Africa

Directory of Open Access Journals (Sweden)

Collins C. Ngwakwe

2014-11-01

Full Text Available This paper examined the relationship between corporate social investment and revenue in Woolworths Holdings Limited South Africa. The approach is thus a single case study, and financial data on social investment and revenue was retrieved from the Woolworths Holdings’ Good Business Journey report 2008 -2013 and from its annual report of 2002 - 2007. Using the SPSS statistics software, a correlation was sought between the Woolworths Holdings’ social investment expenditure and revenue, earnings per share and return on equity. Findings from the analysis revealed that, within the six years of Woolworths Holdings’ Good Business Journey, a significant positive relationship exists between Woolworths Holdings’ social investment and its revenue, earnings per share (EPS and return on equity (ROE. A further analysis of difference in means using the t-test statistics indicates that the revenue streams to Woolworths Holdings’ between 2008 – 2013 is significantly greater than the revenue streams in the six years before the Good Business Journey. In conclusion, the paper suggests a new research model, referred to in this research as the share holders’ support for corporate social investment model, and it is represented as: SHSSI = f (Rv+Es+Re+Of. The paper thus offers an agenda for further research to apply the above model to evaluate the degree of shareholders’ interest and support for corporate social investment in retailing and other companies

'A Stitch in Time?':Repairs and Rejection in Sale of Goods

OpenAIRE

Hood, Parker

2008-01-01

Section 35(6)(a) says there is no acceptance of goods (and, hence, no loss of the right to reject) where a defective good is repaired, pursuant to 'an arrangement with the seller'. However, what is the position where the seller, having repaired the goods, does not tell the buyer what the fault was or what was done to rectify it? In such a case, the House of Lords has held the buyer can still reject the goods, even where the seller says they are 'as good as new'. The basis for doing so was an ...

Evaluating and Optimizing Online Advertising: Forget the Click, but There Are Good Proxies.

Science.gov (United States)

Dalessandro, Brian; Hook, Rod; Perlich, Claudia; Provost, Foster

2015-06-01

Online systems promise to improve advertisement targeting via the massive and detailed data available. However, there often is too few data on exactly the outcome of interest, such as purchases, for accurate campaign evaluation and optimization (due to low conversion rates, cold start periods, lack of instrumentation of offline purchases, and long purchase cycles). This paper presents a detailed treatment of proxy modeling, which is based on the identification of a suitable alternative (proxy) target variable when data on the true objective is in short supply (or even completely nonexistent). The paper has a two-fold contribution. First, the potential of proxy modeling is demonstrated clearly, based on a massive-scale experiment across 58 real online advertising campaigns. Second, we assess the value of different specific proxies for evaluating and optimizing online display advertising, showing striking results. The results include bad news and good news. The most commonly cited and used proxy is a click on an ad. The bad news is that across a large number of campaigns, clicks are not good proxies for evaluation or for optimization: clickers do not resemble buyers. The good news is that an alternative sort of proxy performs remarkably well: observed visits to the brand's website. Specifically, predictive models built based on brand site visits-which are much more common than purchases-do a remarkably good job of predicting which browsers will make a purchase. The practical bottom line: evaluating and optimizing campaigns using clicks seems wrongheaded; however, there is an easy and attractive alternative-use a well-chosen site-visit proxy instead.

Good supervision and PBL

DEFF Research Database (Denmark)

Otrel-Cass, Kathrin

This field study was conducted at the Faculty of Social Sciences at Aalborg University with the intention to investigate how students reflect on their experiences with supervision in a PBL environment. The overall aim of this study was to inform about the continued work in strengthening supervision...... at this faculty. This particular study invited Master level students to discuss: • How a typical supervision process proceeds • How they experienced and what they expected of PBL in the supervision process • What makes a good supervision process...

My Goodness, My Heritage! Constructing Good Heritage in the Irish Economic Crisis

Directory of Open Access Journals (Sweden)

Maja Lagerqvist

2015-06-01

Full Text Available In 2008, the Republic of Ireland entered a severe financial crisis partly as a part of the global economic crisis. Since then, it has seen large raises in income taxes and cuts in state spending on health, welfare, education and on heritage, which has suffered relatively large cuts. This implies a need for rethinking choices and prioritisations to cope with the changing circumstances. Across Europe, the effects of the crisis on heritage, or the whole cultural sector, have yet mostly been highlighted in general or supposed terms rather than empirically analysed. But what actually happens to how heritage is conceptualised in times of crisis? Inspired by Critical Discourse Analysis, this paper explores representation of and argumentation for heritage in Irish state heritage policies pre and post the recession 2008. Much concerns regarding heritage management are discursively shaped. Policies, stating the authorised viewpoint, are thus key in the construction of heritage and its values in society. Recently, research has highlighted a shift towards more instrumentality in cultural policy due to wider societal changes. A crisis could influence such development. The analysis departs from an often-stated notion of heritage as a part of the Irish national recovery, but what does that imply? Focus is therefore put on how different representations of heritage and its values are present, argued for and compete in a situation with increasing competition regarding relevance and support. The paper shows how heritage matters are refocused, streamlined and packaged as productive, good-for-all, unproblematic and decomplexified in order to be perceived and valued as part of the national recovery. This includes privileging certain instrumental values, foremost economic, by means of specificity, space and quantification, while heritage's contribution to social life, education or health, although often mentioned, are downplayed by being expressed in much more vague

[Can tobacco companies be good corporate citizens?].

Science.gov (United States)

Palazzo, G; Mena, S

2009-07-01

Tobacco companies have jumped on the Corporate social responsibility (CSR) bandwagon as a tentative to be societally accepted as responsible actors and good corporate citizens. This is however not possible for two reasons. First, the product they sell is lethal and thus not compatible with the precondition of doing no harm to be a good corporate citizen. Second, the behavior of tobacco firms is not responsible, being illustrated by four examples: junk science versus sound science strategy, seducing young smokers, political lobbying and getting customers on new markets. To conclude, three implications for regulating the activities of the tobacco industry are given.

Daily Tips for Good Oral Hygiene

Science.gov (United States)

... this article Daily Tips for Good Oral Hygiene Bacteria can live in your mouth in the form of plaque, causing cavities and gingivitis, which can lead to periodontal (gum) disease. In order to keep your mouth ...

Ordinance on the transport of dangerous goods by road (SDR)

International Nuclear Information System (INIS)

1985-04-01

This Ordinance regulates the transport of dangerous goods by road and replaces a similar Ordinance of 1972. The dangerous goods are listed in Annex A and the special provisions to be complied with for their transport are contained in Annex B. Radioactive materials, categorized as Class IVb, are included in the goods covered by the Ordinance. The Ordinance which entered into force on 1 May 1985 was amended on 9 April 1987 on a minor point and on 27 November 1989 so as to provide for special training for drivers of vehicles carrying such goods. This latter amendment entered into force on 1 January 1990. (NEA) [fr

Pure Red Cell Aplasia Associated with Good Syndrome

Directory of Open Access Journals (Sweden)

Masayuki Okui

2017-04-01

Full Text Available Pure red cell aplasia (PRCA and hypogammaglobulinemia are paraneoplastic syndromes that are rarer than myasthenia gravis in patients with thymoma. Good syndrome coexisting with PRCA is an extremely rare pathology. We report the case of a 50-year-old man with thymoma and PRCA associated with Good syndrome who achieved complete PRCA remission after thymectomy and postoperative immunosuppressive therapy, and provide a review of the pertinent literature.

Promoting good health research practice in low- and middle-income countries

Directory of Open Access Journals (Sweden)

Yodi Mahendradhata

2016-08-01

Full Text Available Background: Good clinical practice (GCP guidelines have been the source of improvement in the quality of clinical trials; however, there are limitations to the application of GCP in the conduct of health research beyond industry-sponsored clinical trials. The UNICEF/UNDP/World Bank/WHO Special Program for Research and Training in Tropical Disease is promoting good practice in all health research involving human through the Good Health Research Practice (GHRP training program initiative. Objective: To report the results of piloting the GHRP training program and formulate further steps to harness GHRP for promoting good practices in all health research involving human, particularly in low- and middle-income countries (LMICs. Design: The objective of this training is to impart knowledge and skills for the application of ethical and quality principles to the design, conduct, recording, and reporting of health research involving human participants based on the level of risk, to ensure a fit-for-purpose quality system. This has been formulated into five sequential modules to be delivered in a 4-day course. Four courses have been organized in the pilot phase (2014–2015. The courses have been evaluated and assessed based on course feedback (quantitative and qualitative data collected during course implementation and qualitative email-based pre- and post-course evaluation. Results: Participants were highly satisfied with the course content and its organization. The relevance and applicability of the course content resulted in positive feedback and an articulated willingness to adapt and disseminate the course. Action points to strengthen the training program have been identified, and showed the imminent need to develop a consensus with a broader range of key stakeholders on the final set of GHRP standards and means for implementation. Conclusions: There is an urgent need to harness the momentum to promote high-quality and ethical health research in

Good governance, service delivery and records: the African tragedy ...

African Journals Online (AJOL)

A paper tasked to establish the relationship between records, good governance and service delivery, especially in Africa, runs into immediate definitional ambiguities. This is because good governance and service delivery mean different things to different African leaders. Moreover, even the most criminal and tyrannical ...

Good e-Governance and Cadastral Innovation:

African Journals Online (AJOL)

Simon Hull

Good e-Governance and Cadastral Innovation: In Pursuit of a ... The development and implementation of an e-cadastre, called Project Vulindlela, is underway in. South Africa yet ...... In Proceeding of the 5th FIG Regional Conference. Accra,.

Governing Civil Society Organisations and Constructing the Common Good

DEFF Research Database (Denmark)

Hein Jessen, Mathias

This paper argues that civil society is something that must be produced and constructed in order to come into existence. This construction entails a specific production of what civil society is, which values are (and should be) present in it, what the common good is and how civil society and civil...... with specific (good) values, but is at the same time instrumentalised to provide welfare services the state can and will no longer provide. Civil society, civil society organisations and the common good are not given entities, but constantly produced and mobilised in different political conjunctures....

A DETAILED STUDY OF PHOTOMETRIC REDSHIFTS FOR GOODS-SOUTH GALAXIES

International Nuclear Information System (INIS)

Dahlen, Tomas; Ferguson, Henry C.; Grogin, Norman A.; Koekemoer, Anton; Mobasher, Bahram; Dickinson, Mark; Giavalisco, Mauro; Guo, Yicheng; Salimbeni, Sara; Lee, Kyoung-Soo; Lee, Seong-Kook; Riess, Adam G.; Nonino, Mario

2010-01-01

We use the deepest and the most comprehensive photometric data currently available for GOODS-South (GOODS-S) galaxies to measure their photometric redshifts. The photometry includes VLT/VIMOS (U band), HST/ACS (F435W, F606W, F775W, and F850LP bands), VLT/ISAAC (J, H, and K s bands), and four Spitzer/IRAC channels (3.6, 4.5, 5.8, and 8.0 μm). The catalog is selected in the z band (F850LP) and photometry in each band is carried out using the recently completed TFIT algorithm, which performs point-spread function (PSF) matched photometry uniformly across different instruments and filters, despite large variations in PSFs and pixel scales. Photometric redshifts are derived using the GOODZ code, which is based on the template fitting method using priors. The code also implements 'training' of the template spectral energy distribution (SED) set, using available spectroscopic redshifts in order to minimize systematic differences between the templates and the SEDs of the observed galaxies. Our final catalog covers an area of 153 arcmin 2 and includes photometric redshifts for a total of 32,505 objects. The scatter between our estimated photometric and spectroscopic redshifts is σ = 0.040 with 3.7% outliers to the full z-band depth of our catalog, decreasing to σ = 0.039 and 2.1% outliers at a magnitude limit m z < 24.5. This is consistent with the best results previously published for GOODS-S galaxies, however, the present catalog is the deepest yet available and provides photometric redshifts for significantly more objects to deeper flux limits and higher redshifts than earlier works. Furthermore, we show that the photometric redshifts estimated here for galaxies selected as dropouts are consistent with those expected based on the Lyman break technique.