WorldWideScience

Sample records for scant evidence exists

  1. International public procurement: From scant facts to hard data

    OpenAIRE

    Cernat, Lucian; Kutlina-Dimitrova, Zornitsa

    2015-01-01

    Public procurement is a negotiating area gaining in importance at multilateral and bilateral level, as evidenced by a brief review of procurement provisions in existing trade agreements. The size of procurement spending stands in most developed economies at double-digit percentage points of GDP. However, despite the size and importance of these markets, the factual information available to trade negotiators remains scarce. Although public procurement patterns (e.g. size of procurement markets...

  2. The value of self-medication: summary of existing evidence.

    Science.gov (United States)

    Noone, Joshua; Blanchette, Christopher M

    2018-02-01

    The aim of this review was to identify the international evidence that is currently available on the economic value of self-care through responsible self-medication, in terms of the measures related to access to treatment, time, and productivity. A targeted literature search was conducted for 1990-2016, including data gathered from members of the World Self-Medication Industry and searches on PubMed, EBSCOHost, and Google Scholar. Specific searches of individual drug classes known to be switched to non-prescription status in this period were also conducted. A total of 71 articles were identified, of which 17 (11 modeling studies, six retrospective analyses) were included in the review. Evidence from modeling studies and retrospective analyses of grouped data across a range of common conditions for which non-prescription medications are available in different countries/regions showed that the use of non-prescription products for the treatment of common conditions or for symptom management (e.g. allergies, chronic pain, migraine, vaginitis, gastrointestinal symptoms, or common cold symptoms) had considerable value to patients, payers, and employers alike in terms of cost savings and improved productivity. Potential benefits of self-medication were also identified in preventative healthcare strategies, such as those for cardiovascular health and osteoporosis. This review was limited by a targeted, but non-systematic approach to literature retrieval, as well as the inclusion of unpublished reports/white papers and patient self-reported data. The evidence identified in this literature review shows that responsible, appropriate self-medication with non-prescription products can provide significant economic benefits for patients, employers, and healthcare systems worldwide.

  3. Existing Evidence on Ultrasound-Guided Injections in Sports Medicine.

    Science.gov (United States)

    Daniels, Eldra W; Cole, David; Jacobs, Bret; Phillips, Shawn F

    2018-02-01

    Office-based ultrasonography has become increasingly available in many settings, and its use to guide joint and soft tissue injections has increased. Numerous studies have been conducted to evaluate the use of ultrasound-guided injections over traditional landmark-guided injections, with a rapid growth in the literature over the past few years. A comprehensive review of the literature was conducted to demonstrate increased accuracy of ultrasound-guided injections regardless of anatomic location. In the upper extremity, ultrasound-guided injections have been shown to provide superior benefit to landmark-guided injections at the glenohumeral joint, the subacromial space, the biceps tendon sheath, and the joints of the hand and wrist. Ultrasound-guided injections of the acromioclavicular and the elbow joints have not been shown to be more efficacious. In the lower extremity, ultrasound-guided injections at the knee, ankle, and foot have superior efficacy to landmark-guided injections. Conclusive evidence is not available regarding improved efficacy of ultrasound-guided injections of the hip, although landmark-guided injection is performed less commonly at the hip joint. Ultrasound-guided injections are overall more accurate than landmark-guided injections. While current studies indicate that ultrasound guidance improves efficacy and cost-effectiveness of many injections, these studies are limited and more research is needed.

  4. Comparing the Incomparable: An Essay on the Importance of Big Assumptions and Scant Evidence.

    Science.gov (United States)

    Wainer, Howard

    1999-01-01

    Discusses the comparison of groups of individuals who were administered different forms of a test. Focuses on the situation in which there is little overlap in content between the test forms. Reviews equating problems in national tests in Canada and Israel. (SLD)

  5. Evidence for the existence of supercooled ethane droplets under conditions prevalent in Titan's atmosphere.

    Science.gov (United States)

    Sigurbjörnsson, Omar F; Signorell, Ruth

    2008-11-07

    Recent evidence for ethane clouds and condensation in Titan's atmosphere raise the question whether liquid ethane condensation nuclei and supercooled liquid ethane droplets exist under the prevalent conditions. We present laboratory studies on the phase behaviour of pure ethane aerosols and ethane aerosols formed in the presence of other ice nuclei under conditions relevant to Titan's atmosphere. Combining bath gas cooling with infrared spectroscopy, we find evidence for the existence of supercooled liquid ethane aerosol droplets. The observed homogeneous freezing rates imply that supercooled ethane could be a long-lived species in ethane-rich regions of Titan's atmosphere similar to supercooled water in the Earth's atmosphere.

  6. Self-Evident Propositions in Late Scholasticism. The Case of 'God Exists'

    Czech Academy of Sciences Publication Activity Database

    Dvořák, Petr

    -, č. 27/51 (2013), s. 47-73 ISSN 0231-5955 R&D Projects: GA ČR(CZ) GAP401/11/0371 Institutional support: RVO:67985955 Keywords : God 's existence * self-evident proposition * Scholasticism Subject RIV: AA - Philosophy ; Religion

  7. Environmental Education in Pre-Service Teacher Training: A Literature Review of Existing Evidence

    Science.gov (United States)

    Álvarez-García, Olaya; Sureda-Negre, Jaume; Comas-Forgas, Rubén

    2015-01-01

    The importance of pre-service teacher training regarding environmental education (EE) has been vastly demonstrated. This systematic review examined the existing evidence from studies evaluating and analysing the relationship between EE, including environmental competences and pre-service primary school teacher training. The literature review…

  8. Evaluating Existing and New Validity Evidence for the Academic Motivation Scale

    Science.gov (United States)

    Fairchild, Amanda J.; Horst, S. Jeanne; Finney, Sara J.; Barron, Kenneth E.

    2005-01-01

    The current study evaluates existing and new validity evidence for the Academic Motivation Scale (AMS; Vallerand et al., 1992). We first provide a narrative review synthesizing past research, and then conduct a validity investigation of the scores from the measure. Data analysis using a sample of 1406 American college students provided construct…

  9. Possible evidence for the existence of antimatter on a cosmological scale in the universe.

    Science.gov (United States)

    Stecker, F. W.; Morgan, D. L., Jr.; Bredekamp, J.

    1971-01-01

    Initial results of a detailed calculation of the cosmological gamma-ray spectrum from matter-antimatter annihilation in the universe. The similarity between the calculated spectrum and the present observations of the gamma-ray background spectrum above 1 MeV suggests that such observations may be evidence of the existence of antimatter on a large scale in the universe.

  10. Long-term Trends of Organic Carbon Concentrations in Freshwaters: Strengths and Weaknesses of Existing Evidence

    Directory of Open Access Journals (Sweden)

    Montserrat Filella

    2014-05-01

    Full Text Available Many articles published in the last few years start with the assumption that the past decades have seen an increase in dissolved organic carbon (DOC concentrations in the rivers and lakes of the Northern Hemisphere. This study analyses whether the existing evidence supports this claim. With this aim, we have collected published studies where long series of organic carbon concentrations (i.e., longer than 10 years were analyzed for existing trends and have carefully evaluated the 63 articles found. Information has been collated in a comprehensive and comparable way, allowing readers to easily access it. The two main aspects considered in our analysis have been the analytical methods used and the data treatment methods applied. Both are sensitive issues because, on the one hand, the difficulties associated with correctly determining organic carbon concentrations in surface waters are well known, while, on the other, dealing with real environmental data (i.e., lack of normality, censoring, missing values, etc. is an extremely intricate matter. Other issues such as data reporting and the geographical location of the systems studied are also discussed. In conclusion, it is clear that organic carbon concentrations have increased in some surface waters in the Northern Hemisphere since the 1990s. However, due to a lack of data in many parts of the world, it is not known whether this phenomenon is general and, more importantly, in the areas for which such data do exist, the reporting and methodological problems in the published studies prevent any conclusion on the existence of a general temporal behavior of organic carbon from being drawn.

  11. Experimental evidence showing that no mitotically active female germline progenitors exist in postnatal mouse ovaries.

    Science.gov (United States)

    Zhang, Hua; Zheng, Wenjing; Shen, Yan; Adhikari, Deepak; Ueno, Hiroo; Liu, Kui

    2012-07-31

    It has been generally accepted for more than half a century that, in most mammalian species, oocytes cannot renew themselves in postnatal or adult life, and that the number of oocytes is already fixed in fetal or neonatal ovaries. This assumption, however, has been challenged over the past decade. In this study, we have taken an endogenous genetic approach to this question and generated a multiple fluorescent Rosa26(rbw/+);Ddx4-Cre germline reporter mouse model for in vivo and in vitro tracing of the development of female germline cell lineage. Through live cell imaging and de novo folliculogenesis experiments, we show that the Ddx4-expressing cells from postnatal mouse ovaries did not enter mitosis, nor did they contribute to oocytes during de novo folliculogenesis. Our results provide evidence that supports the traditional view that no postnatal follicular renewal occurs in mammals, and no mitotically active Ddx4-expressing female germline progenitors exist in postnatal mouse ovaries.

  12. Knowledge and awareness of Canadian Physical Activity and Sedentary Behaviour Guidelines: a synthesis of existing evidence.

    Science.gov (United States)

    LeBlanc, Allana G; Berry, Tanya; Deshpande, Sameer; Duggan, Mary; Faulkner, Guy; Latimer-Cheung, Amy E; O'Reilly, Norm; Rhodes, Ryan E; Spence, John C; Tremblay, Mark S

    2015-07-01

    The aim of this review was to consolidate and synthesize existing evidence regarding current knowledge and awareness of the Canadian Physical Activity (PA) and Sedentary Behaviour (SB) Guidelines. MEDLINE, Embase, and PsycINFO were searched for peer-reviewed publications pertaining to the guidelines. Content experts, key organizations (i.e., ParticipACTION and the Canadian Fitness and Lifestyle Research Institute), journal Web sites, and service organizations (i.e., the Canadian Society for Exercise Physiology (CSEP) and the Public Health Agency of Canada) were consulted for additional evidence. Scientific publications (n = 6) and research from ParticipACTION and the Canadian Fitness and Lifestyle Research Institute reported that awareness of the guidelines is low, especially with respect to the SB guidelines. Less than 10% of survey respondents from the Canadian population were aware of the PA guidelines, and less than 5% were aware of the SB guidelines. Information on the guidelines was available on 51% of public health unit and CSEP partner Web sites. Online metrics (e.g., downloads, site accessions) from CSEP, the Public Health Agency of Canada, and journal Web sites showed that online accession of the guidelines was high (e.g., all "highly accessed" on journal Web sites). This review showed that awareness of the Canadian PA and SB Guidelines is low among the general population but higher among the scientific and stakeholder communities. Governmental, nongovernmental, and stakeholder organizations should collaborate in creating sustained, long-term, and well-resourced communication plans to reach the Canadian population to raise awareness of PA and SB guidelines and should implement programs to facilitate their uptake.

  13. Missed, Not Missing: Phylogenomic Evidence for the Existence of Avian FoxP3.

    Directory of Open Access Journals (Sweden)

    Michael P Denyer

    Full Text Available The Forkhead box transcription factor FoxP3 is pivotal to the development and function of regulatory T cells (Tregs, which make a major contribution to peripheral tolerance. FoxP3 is believed to perform a regulatory role in all the vertebrate species in which it has been detected. The prevailing view is that FoxP3 is absent in birds and that avian Tregs rely on alternative developmental and suppressive pathways. Prompted by the automated annotation of foxp3 in the ground tit (Parus humilis genome, we have questioned this assumption. Our analysis of all available avian genomes has revealed that the foxp3 locus is missing, incomplete or of poor quality in the relevant genomic assemblies for nearly all avian species. Nevertheless, in two species, the peregrine falcon (Falco peregrinus and the saker falcon (F. cherrug, there is compelling evidence for the existence of exons showing synteny with foxp3 in the ground tit. A broader phylogenomic analysis has shown that FoxP3 sequences from these three species are similar to crocodilian sequences, the closest living relatives of birds. In both birds and crocodilians, we have also identified a highly proline-enriched region at the N terminus of FoxP3, a region previously identified only in mammals.

  14. Direct evidence of the existence of Mn3+ ions in MnTiO3

    Science.gov (United States)

    Maurya, R. K.; Sharma, Priyamedha; Patel, Ashutosh; Bindu, R.

    2017-08-01

    We investigate the room temperature electronic properties of MnTiO3 synthesised by different preparation conditions. For this purpose, we prepared MnTiO3 under two different cooling rates, one is naturally cooled while the other is quenched in liq.nitrogen. The samples were studied using optical absorbance, photoemission spectroscopy and band structure calculations. We observe significant changes in the structural parameters as a result of quenching. Interestingly, in the parent compound, our combined core level, valence band and optical absorbance studies give evidence of the Mn existence in both 2+ and 3+ states. The fraction of Mn3+ ions has been found to increase on quenching MnTiO3 suggests an increase in oxygen non-stoichiometry. The increase in the fraction of the Mn3+ ions has been manifested a) as slight enhancement in the intensity of the optical absorbance in the visible region. There occurs persistent photo-resistance when the incident light is terminated after shining; b) in the behaviour of the features (close to Fermi level) in the valence band spectra. Hence, the combined analysis of the core level, valence band and optical absorbance spectra suggests that the charge carriers are hole like which further leads to the increase in the electrical conductivity of the quenched sample. The present results provide a recipe to tune the optical absorption in the visible range for its applications in optical sensors, solar cell, etc.

  15. Is Delirium the Cognitive Harbinger of Frailty in Older Adults? A Review about the Existing Evidence

    Directory of Open Access Journals (Sweden)

    Giuseppe Bellelli

    2017-11-01

    Full Text Available Frailty is a clinical syndrome defined by the age-related depletion of the individual’s homeostatic reserves, determining an increased susceptibility to stressors and disproportionate exposure to negative health changes. The physiological systems that are involved in the determination of frailty are mutually interrelated, so that when decline starts in a given system, implications may also regard the other systems. Indeed, it has been shown that the number of abnormal systems is more predictive of frailty than those of the abnormalities in any particular system. Delirium is a transient neurocognitive disorder, characterized by an acute onset and fluctuating course, inattention, cognitive dysfunction, and behavioral abnormalities, that complicates one out of five hospital admissions. Delirium is independently associated with the same negative outcomes of frailty and, like frailty, its pathogenesis is usually multifactorial, depending on complex inter-relationships between predisposing and precipitating factors. By definition, a somatic cause should be identified, or at least suspected, to diagnose delirium. Delirium and frailty potentially share multiple pathophysiologic mechanisms and pathways, meaning that they could be thought of as the two sides to the same coin. This review aims at summarizing the existing evidence, referring both to human and animal models, to postulate that delirium may represent the cognitive harbinger of a state of frailty in older persons experiencing an acute clinical event.

  16. A scoping research literature review to assess the state of existing evidence on the "bad" death.

    Science.gov (United States)

    Wilson, Donna M; Hewitt, Jessica A

    2018-02-01

    A scoping research literature review on "bad death" was undertaken to assess the overall state of the science on this topic and to determine what evidence exists on how often bad deaths occur, what contributes to or causes a bad death, and what the outcomes and consequences of bad deaths are. A search for English-language research articles was conducted in late 2016, with 25 articles identified and all retained for examination, as is expected with scoping reviews. Only 3 of the 25 articles provided incidence information, specifying that 7.8 to 23% of deaths were bad and that bad deaths were more likely to occur in hospitals than in community-care settings. Many different factors were associated with bad deaths, with unrelieved pain being the most commonly identified. Half of the studies provided information on the possible consequences or outcomes of bad deaths, such as palliative care not being initiated, interpersonal and team conflict, and long-lasting negative community effects. This review identified a relatively small number of research articles that focused in whole or in part on bad deaths. Although the reasons why people consider a death to be bad may be highly individualized and yet also socioculturally based, unrelieved pain is a commonly held reason for bad deaths. Although bad and good deaths may have some opposing causative factors, this literature review revealed some salient bad death attributes, ones that could be avoided to prevent bad deaths from occurring. A routine assessment to allow planning so as to avoid bad deaths and enhance the probability of good deaths is suggested.

  17. Evidence for the existence of Gribov copies in Landau gauge lattice QCD

    Energy Technology Data Exchange (ETDEWEB)

    Marinari, E.; Ricci, R. (Rome-2 Univ. (Italy). Dipt. di Fisica INFN, Rome (Italy)); Parrinello, C. (New York Univ., NY (USA). Physics Dept.)

    1991-09-16

    We unambiguously show the existence of Gribov copies in a pure SU(3) gauge lattice model, with Wilson action. We show that the usual steepest-descent algorithms used for implementing the lattice Landau gauge lead to ambiguities, which are related to the existence of Gribov copies in the model. (orig.).

  18. Maternal ratings of attention problems in ADHD: evidence for the existence of a continuum

    NARCIS (Netherlands)

    Lubke, Gitta H.; Hudziak, James J.; Derks, Eske M.; van Bijsterveldt, Toos C. E. M.; Boomsma, Dorret I.

    2009-01-01

    To investigate whether items assessing attention problems provide evidence of quantitative differences or categorically distinct subtypes of attention problems (APs) and to investigate the relation of empirically derived latent classes to DSM-IV diagnoses of subtypes of

  19. Where Does Evidence from New Trials for Schizophrenia Fit with the Existing Evidence: A Case of the Emperor's New Clothes?

    Directory of Open Access Journals (Sweden)

    Mahesh Jayaram

    2012-01-01

    Full Text Available Advent of “atypical” antipsychotics has spawned new trials in the recent years and the number of such trial reports has been increasing exponentially. As clinicians we have been led to believe that “atypicals” are better than “typicals” despite the odd dissenting voice in academic and clinical circles. This has been largely ignored until the publication of two landmark, independent, pragmatic trials, Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE and Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS, which proved that thoughtfully chosen “typical” antipsychotics were as good as the newer “atypicals.” We pooled “leaving the study early data” from Cochrane Reviews that existed before CATIE and CUtLASS and added data from CATIE and CUtLASS to the pool for a “before and after” comparison. Addition of CATIE and CUtLASS data only led to narrowing of the already existing confidence intervals, merely increasing precision, and decreasing the risk of Type II error. Perhaps surprisingly, CATIE and CUtLASS when pooled with the already existing data showed us that we had chosen to turn a blind eye to findings that already existed. This leads clinicians to question as to whether, in future, we need to feel less guilty about crying out early on that the emperor has no clothes on.

  20. Up and down the blind alley: population divergence with scant gene flow in an endangered tropical lineage of Andean palms (Ceroxylon quindiuense clade: Ceroxyloideae).

    Science.gov (United States)

    Sanín, María José; Zapata, Patricia; Pintaud, Jean-Christophe; Galeano, Gloria; Bohórquez, Adriana; Tohme, Joseph; Hansen, Michael Møller

    2017-02-10

    Given the geographical complexity of the Andes, species distributions hold interesting information regarding the history of isolation and gene flow across geographic barriers and ecological gradients. Moreover, current threats to the region’s enormous plant diversity pose an additional challenge to the understanding of these patterns. We explored the geographic structure of genetic diversity within the Ceroxylon quindiuense species complex (wax palms) at a regional scale, using a model-based approach to disentangle the historical mechanisms by which these species have dispersed over a range encompassing 17° of latitude in the tropical Andes. A total of 10 microsatellite loci were cross-amplified in 8 populations of the 3 species comprising the C. quindiuense complex. Analyses performed include estimates of molecular diversity and genetic structure, testing for genetic bottlenecks and an evaluation of the colonization scenario under approximate Bayesian computation. We showed that there was a geographical diversity gradient reflecting the orogenetic pattern of the northern Andes and its end at the cordilleras facing the Caribbean Sea. A general pattern of diversity suggests that the cordilleras of Colombia have served as historical recipients of gene flow occurring only scantly along the northern Andes. We provided evidence of important isolation between the largest populations of this complex, suggesting that both historical constraints to dispersal but also current anthropogenic effects might explain the high levels of population structuring. We provide a list of advisable measures for conservation stakeholders.

  1. Does a Protestant work ethic exist? Evidence from the well-being effect of unemployment

    NARCIS (Netherlands)

    van Hoorn, Andre; Maseland, Robbert

    Evidence on Weber's original thesis on a Protestant work ethic is ambiguous and relies on questionable measures of work attitudes. We test the relation between Protestantism and work attitudes using a novel method,.operationalizing work ethic as the effect of unemployment on-individuals' subjective

  2. Evidence that gendered wording in job advertisements exists and sustains gender inequality.

    Science.gov (United States)

    Gaucher, Danielle; Friesen, Justin; Kay, Aaron C

    2011-07-01

    Social dominance theory (Sidanius & Pratto, 1999) contends that institutional-level mechanisms exist that reinforce and perpetuate existing group-based inequalities, but very few such mechanisms have been empirically demonstrated. We propose that gendered wording (i.e., masculine- and feminine-themed words, such as those associated with gender stereotypes) may be a heretofore unacknowledged, institutional-level mechanism of inequality maintenance. Employing both archival and experimental analyses, the present research demonstrates that gendered wording commonly employed in job recruitment materials can maintain gender inequality in traditionally male-dominated occupations. Studies 1 and 2 demonstrated the existence of subtle but systematic wording differences within a randomly sampled set of job advertisements. Results indicated that job advertisements for male-dominated areas employed greater masculine wording (i.e., words associated with male stereotypes, such as leader, competitive, dominant) than advertisements within female-dominated areas. No difference in the presence of feminine wording (i.e., words associated with female stereotypes, such as support, understand, interpersonal) emerged across male- and female-dominated areas. Next, the consequences of highly masculine wording were tested across 3 experimental studies. When job advertisements were constructed to include more masculine than feminine wording, participants perceived more men within these occupations (Study 3), and importantly, women found these jobs less appealing (Studies 4 and 5). Results confirmed that perceptions of belongingness (but not perceived skills) mediated the effect of gendered wording on job appeal (Study 5). The function of gendered wording in maintaining traditional gender divisions, implications for gender parity, and theoretical models of inequality are discussed. PsycINFO Database Record (c) 2011 APA, all rights reserved.

  3. Evidences for existence of a strange meson with the 1627 MeV/c2 mass

    International Nuclear Information System (INIS)

    Karnaukhov, V.M.; Moroz, V.I.; Coca, C.

    1995-01-01

    The narrow structure with Μ=(1627±4) MeV/c 2 and Γ=(12 -12 +14 ) MeV/c 2 is observable in π - p interactions at 16 GeV/c in 6 effective mass spectra of the Kmπ systems. In the summed spectrum the number of standard deviations in the structure region over the background is 10. A performed compilative analysis of paper results on the study of strange meson resonances in various experiments does not contradict indication for the existence of K(1627)-meson, a narrow enhancement is observed in the same mass region. (author). 21 refs., 4 figs

  4. Little Evidence Exists To Support The Expectation That Providers Would Consolidate To Enter New Payment Models.

    Science.gov (United States)

    Neprash, Hannah T; Chernew, Michael E; McWilliams, J Michael

    2017-02-01

    Provider consolidation has been associated with higher health care prices and spending. The prevailing wisdom is that payment reform will accelerate consolidation, especially between physicians and hospitals and among physician groups, as providers position themselves to bear financial risk for the full continuum of patient care. Drawing on data from a number of sources from 2008 onward, we examined the relationship between Medicare's accountable care organization (ACO) programs and provider consolidation. We found that consolidation was under way in the period 2008-10, before the Affordable Care Act (ACA) established the ACO programs. While the number of hospital mergers and the size of specialty-oriented physician groups increased after the ACA was passed, we found minimal evidence that consolidation was associated with ACO penetration at the market level or with physicians' participation in ACOs within markets. We conclude that payment reform has been associated with little acceleration in consolidation in addition to trends already under way, but there is evidence of potential defensive consolidation in response to new payment models. Project HOPE—The People-to-People Health Foundation, Inc.

  5. Evidence for the Existing American Nurses Association-Recognized Standardized Nursing Terminologies: A Systematic Review

    Science.gov (United States)

    Tastan, Sevinc; Linch, Graciele C. F.; Keenan, Gail M.; Stifter, Janet; McKinney, Dawn; Fahey, Linda; Dunn Lopez, Karen; Yao, Yingwei; Wilkie, Diana J.

    2014-01-01

    Objective To determine the state of the science for the five standardized nursing terminology sets in terms of level of evidence and study focus. Design Systematic Review. Data sources Keyword search of PubMed, CINAHL, and EMBASE databases from 1960s to March 19, 2012 revealed 1,257 publications. Review Methods From abstract review we removed duplicate articles, those not in English or with no identifiable standardized nursing terminology, and those with a low-level of evidence. From full text review of the remaining 312 articles, eight trained raters used a coding system to record standardized nursing terminology names, publication year, country, and study focus. Inter-rater reliability confirmed the level of evidence. We analyzed coded results. Results On average there were 4 studies per year between 1985 and 1995. The yearly number increased to 14 for the decade between 1996–2005, 21 between 2006–2010, and 25 in 2011. Investigators conducted the research in 27 countries. By evidence level for the 312 studies 72.4% were descriptive, 18.9% were observational, and 8.7% were intervention studies. Of the 312 reports, 72.1% focused on North American Nursing Diagnosis-International, Nursing Interventions Classification, Nursing Outcome Classification, or some combination of those three standardized nursing terminologies; 9.6% on Omaha System; 7.1% on International Classification for Nursing Practice; 1.6% on Clinical Care Classification/Home Health Care Classification; 1.6% on Perioperative Nursing Data Set; and 8.0% on two or more standardized nursing terminology sets. There were studies in all 10 foci categories including those focused on concept analysis/classification infrastructure (n = 43), the identification of the standardized nursing terminology concepts applicable to a health setting from registered nurses’ documentation (n = 54), mapping one terminology to another (n = 58), implementation of standardized nursing terminologies into electronic health

  6. Familiality of co-existing ADHD and tic disorders: evidence from a large sibling study

    Directory of Open Access Journals (Sweden)

    Veit Roessner

    2016-07-01

    Full Text Available AbstractBackground: The association of attention-deficit/hyperactivity disorder (ADHD and tic disorder (TD is frequent and clinically important. Very few and inconclusive attempts have been made to clarify if and how the combination of ADHD+TD runs in families. Aim: To determine the first time in a large-scale ADHD sample whether ADHD+TD increases the risk of ADHD+TD in siblings and, also the first time, if this is independent of their psychopathological vulnerability in general. Methods: The study is based on the International Multicenter ADHD Genetics (IMAGE study. The present sub-sample of 2815 individuals included ADHD-index patients with co-existing TD (ADHD+TD, n=262 and without TD (ADHD-TD, n=947 as well as their 1606 full siblings (n=358 of the ADHD+TD index patients and n=1248 of the ADHD-TD index patients. We assessed psychopathological symptoms in index patients and siblings by using the strength and difficulties questionnaire (SDQ and the parent and teacher Conners’ long version Rating Scales (CRS. For disorder classification the Parental Account of Childhood Symptoms (PACS-Interview was applied in n = 271 children. Odds ratio with the GENMOD procedure (PROCGENMOD was used to test if the risk for ADHD, TD and ADHD+TD in siblings was associated with the related index patients’ diagnoses. In order to get an estimate for specificity we compared the four groups for general psychopathological symptoms.Results: Co-existing ADHD+TD in index patients increased the risk of both comorbid ADHD+TD and TD in the siblings of these index patients. These effects did not extend to general psychopathology. Interpretation: Co-existence of ADHD+TD may segregate in families. The same holds true for TD (without ADHD. Hence, the segregation of TD (included in both groups seems to be the determining factor, independent of further behavioral problems. This close relationship between ADHD and TD supports the clinical approach to carefully assess ADHD in

  7. Amplification of the flgE gene provides evidence for the existence of a Brazilian borreliosis

    Directory of Open Access Journals (Sweden)

    Elenice Mantovani

    2012-06-01

    Full Text Available INTRODUCTION: The symptoms of Brazilian borreliosis resemble the clinical manifestations of Lyme disease (LD. However, there are differences between the two in terms of epidemiological and laboratory findings. Primers usually employed to diagnose LD have failed to detect Borrelia strains in Brazil. OBJECTIVE: We aimed to identify the Brazilian Borrelia using a conserved gene that synthesizes the flagellar hook (flgE of Borrelia burgdorferi sensu lato. METHOD: Three patients presenting with erythema migrans and positive epidemiological histories were recruited for the study. Blood samples were collected, and the DNA was extracted by commercial kits. RESULTS: The gene flgE was amplified from DNA of all selected patients. Upon sequencing, these positive samples revealed 99% homology to B. burgdorferi flgE. CONCLUSION: These results support the existence of borreliosis in Brazil. However, it is unclear whether this borreliosis is caused by a genetically modified B. burgdorferi sensu stricto or by a new species of Borrelia spp.

  8. Is there a risk-return trade-off in educational choices? Evidence from Spain

    NARCIS (Netherlands)

    Díaz-Serrano, L.; Hartog, J.

    2006-01-01

    We use data from Spain to test for an effect of earnings variance and skewness on individual wages. We carry out separate estimations for men and women. In accordance with the scant previous evidence mainly focused on the US, we report the existence of a risk-return trade-off across educational

  9. Evidence Suggesting that Ivory-billed Woodpeckers (Campephilus principalis Exist in Florida

    Directory of Open Access Journals (Sweden)

    Daniel J. Mennill

    2006-12-01

    Full Text Available The Ivory-billed Woodpecker (Campephilus principalis disappeared from the forests of southeastern North America in the early 20th Century and for more than 50 years has been widely considered extinct. On 21 May 2005, we detected a bird that we identified as an Ivory-billed Woodpecker in the mature swamp forest along the Choctawhatchee River in the panhandle of Florida. During a subsequent year of research, members of our small search team observed birds that we identified as Ivory-billed Woodpeckers on 14 occasions. We heard sounds that matched descriptions of Ivory-billed Woodpecker acoustic signals on 41 occasions. We recorded 99 putative double knocks and 210 putative kent calls. We located cavities in the size range reported for Ivory-billed Woodpeckers and larger than those of Pileated Woodpeckers (Dryocopus pileatus that have been reported in the literature or that we measured in Alabama. We documented unique foraging signs consistent with the feeding behavior of Ivory-billed Woodpeckers. Our evidence suggests that Ivory-billed Woodpeckers may be present in the forests along the Choctawhatchee River and warrants an expanded search of this bottomland forest habitat.

  10. Road safety and road traffic accidents in Saudi Arabia. A systematic review of existing evidence.

    Science.gov (United States)

    Mansuri, Farah A; Al-Zalabani, Abdulmohsen H; Zalat, Marwa M; Qabshawi, Reem I

    2015-04-01

    To identify the changing trends and crucial preventive approaches to road traffic accidents (RTAs) adopted in the Kingdom of Saudi Arabia (KSA) over the last 2.5 decades, and to analyze aspects previously overlooked. This systematic review was based on evidence of RTAs in KSA. All articles published during the last 25 years on road traffic accident in KSA were analyzed. This study was carried out from December 2013 to May 2014 in the Department of Family and Community Medicine, Taibah University, Al-Madinah Al-Munawwarah, KSA. Road traffic accidents accounted for 83.4% of all trauma admissions in 1984-1989, and no such overall trend was studied thereafter. The most frequently injured body regions as reported in the latest studies were head and neck, followed by upper and lower extremities, which was found to be opposite to that of the studies reported earlier. Hospital data showed an 8% non-significant increase in road accident mortalities in contrast to police records of a 27% significant reduction during the years 2005-2010. Excessive speeding was the most common cause reported in all recent and past studies. Disparity was common in the type of reporting of RTAs, outcome measures, and possible causes over a period of 2.5 decade. All research exclusively looked into the drivers' faults. A sentinel surveillance of road crashes should be kept in place in the secondary and tertiary care hospitals for all regions of KSA.

  11. Evidence for a Priori Existence of Attentional Bias Subgroups in Emotional Processing of Aversive Stimuli

    Directory of Open Access Journals (Sweden)

    Casper H. van Heck

    2017-05-01

    Full Text Available Little is known regarding inter-individual differences in attentional biases for pain-related information; more knowledge is crucial, since these biases have been associated with differences in pain processing as well as in predicting the risk of postoperative pain. The present study investigated EEG correlates of attentional bias patterns for pain-related information, with specific focus on avoidance- and vigilance-like behavior. Forty-one participants performed a dot-probe task, where neutral and pain-related words were used to create neutral, congruent, incongruent, and double (two pain-related words trials. EEG was recorded, which was used to generate ERP's of the word-processing phase and the post-dot phase. Participants were placed in two subgroups based on the direction of their attentional bias (either positive; toward the pain-related words, or negative; away from pain-related words. Using t-profiles, four latency windows were identified on which the two subgroups differed significantly. These latency windows yield areas which correspond with the P1-N1 domain and the P3b for the word-processing phase, while the post-dot phase latency windows cover the areas of the P200 and the P3b. The two subgroups show differences on congruent, incongruent, and the double trials, but interestingly also on the neutral trials. Most notably, the area in the word-phase associated with the P3b is diminished in the subgroup showing a negative bias. The deflections associated with both early and late attentional components, including the P3B, as well as a positive deflection in the timeframe of proposed response evaluation processes differ significantly between subgroups. In this study we demonstrated that different attentional biases exist in the healthy population, by showing differences in ERP's. We also show differences in processing neutral trials, which suggests there are fundamental differences between these groups in processing words in general.

  12. Alcohol as a Risk Factor for Cancer: Existing Evidence in a Global Perspective

    Directory of Open Access Journals (Sweden)

    Nina Roswall

    2015-01-01

    Full Text Available The purpose of the present review is to give an overview of the association between alcohol intake and the risk of developing cancer. Two large-scale expert reports; the World Cancer Research Fund (WCRF/American Institute of Cancer Research (AICR report from 2007, including its continuous update project, and the International Agency for Research of Cancer (IARC monograph from 2012 have extensively reviewed this association in the last decade. We summarize and compare their findings, as well as relate these to the public health impact, with a particular focus on region-specific drinking patterns and disease tendencies. Our findings show that alcohol intake is strongly linked to the risk of developing cancers of the oral cavity, pharynx, larynx, oesophagus, colorectum (in men, and female breast. The two expert reports diverge on the evidence for an association with liver cancer and colorectal cancer in women, which the IARC grades as convincing, but the WCRF/AICR as probable. Despite these discrepancies, there does, however, not seem to be any doubt, that the Population Attributable Fraction of alcohol in relation to cancer is large. As alcohol intake varies largely worldwide, so does, however, also the Population Attributable Fractions, ranging from 10% in Europe to almost 0% in countries where alcohol use is banned. Given the World Health Organization’s prediction, that alcohol intake is increasing, especially in low- and middle-income countries, and steadily high in high-income countries, the need for preventive efforts to curb the number of alcohol-related cancers seems growing, as well as the need for taking a region- and gender-specific approach in both future campaigns as well as future research. The review acknowledges the potential beneficial effects of small doses of alcohol in relation to ischaemic heart disease, but a discussion of this lies without the scope of the present study.

  13. Geochemical evidence for the existence of high-temperature hydrothermal brines at Vesuvio volcano, Italy

    Science.gov (United States)

    Chiodini, Giovanni; Marini, Luigi; Russo, Massimo

    2001-07-01

    A high-temperature hydrothermal system is present underneath the crater area of Vesuvio volcano. It is suggested that NaCl brines reside in the high-temperature reservoir and influence the chemical composition of the gases discharged by the fumaroles of the crater bottom (vents FC1, FC2, and FC5). These have typical hydrothermal compositions, with H 2O and CO 2 as major components, followed by H 2, H 2S, N 2, CH 4, and CO (in order of decreasing contents) and undetectable SO 2, HCl, and HF. Fumarolic H 2O is either meteoric water enriched in 18O through high-temperature water-rock oxygen isotope exchange or a mixture of meteoric and arc-type magmatic water. Fumarolic CO 2 is mainly generated by decarbonation reactions of marine carbonates, but the addition of small amounts of magmatic CO 2 is also possible. All investigated gas species (H 2O, CO 2, CO, CH 4, H 2, H 2S, N 2, and NH 3) equilibrate, probably in a saturated vapor phase, at temperatures of 360 to 370°C for vent FC1 and 430 to 445°C for vents FC2 and FC5. These temperatures are confirmed by the H 2-Ar geoindicator. The minimum salt content of the liquid phase coexisting with the vapor phase is ˜14.9 wt.% NaCl, whereas its maximum salinity corresponds to halite saturation (49.2-52.5 wt.% NaCl). These poorly constrained salinities of NaCl brines reflect in large uncertainties in total fluid pressures, which are estimated to be 260 to 480 bar for vents FC2 and FC5 and 130 to 220 bar for vent FC1. Pressurization in some parts of the hydrothermal system, and its subsequent discharge through hydrofracturing, could explain the relatively frequent seismic crises recorded in the Vesuvio area after the last eruption. An important heat source responsible for hydrothermal circulation is represented by the hot rocks of the eruptive conduits, which have been active from 1631 to 1944. Geochemical evidence suggests that no input of fresh magma at shallow depths took place after the end of the last eruptive period.

  14. The Northeast Greenland Shelf - Evidence of the existence of a pronounced salt-province

    Science.gov (United States)

    Schmitz, T.; Jokat, W.

    2003-04-01

    The Northeast Greenland shelf (NEGS) is the part of the continental margin of east Greenland located between the Jan Mayen Fracture Zone at about 72°N in the south and the Spitzbergen Fracture Zone at 81°N in the north. The eastern boundary, at the shelf edge, is the approximate position of the boundary between continental and oceanic crust and the western boundary is the coastline of Greenland. The shelf has a N-S orientation, is about 1000 km long, and between 125 km (southern part) and 380 km (at 78°N) wide. Based on present data the NEGS can be subdivided into a southern part influenced by Tertiary tectonism and volcanism (approx. 72°N to 75°N) and a northern, nonvolcanic, part (approx. 75°N to 81°N). Today the sedimentary history, stratigraphy, structure and origin of the basement below the sedimentary shelf south of 74°N are reasonable known, but only sparse information exists about the northern part of the shelf. Until 1990 there weren't any seismic lines north of 74°N, and all interpretations of stratigraphy and basin structures of the northern part of the NEGS were based on aeromagnetic data. During the last decade, the first seismic lines were shot over the northern part of the shelf to give more detailed information about sediment thickness, stratigraphy, and the structure of the sedimentary shelf. The area under investigation lies on the nonvolcanic northern part of the shelf between 78°30'N and 81°N. The sea floor topography indicates some submarine banks with water depth as shallow as 30 m, which are separated by valleys up to 500 m deep. These valleys were formed through erosion processes caused by cyclic movements of big grounded glacier tongues during the last ice-ages with a maximum expansion during the Wisconsin-Weichselian glaciation. During two scientific expeditions with the German research icebreaker Polarstern in 1997 and 1999, more than 1100 km of multichannel seismic data were collected. The cruise tracks during seismic

  15. Deficiencies in the transfer and availability of clinical trials evidence: a review of existing systems and standards

    Directory of Open Access Journals (Sweden)

    Valkenhoef Gert

    2012-09-01

    Full Text Available Abstract Background Decisions concerning drug safety and efficacy are generally based on pivotal evidence provided by clinical trials. Unfortunately, finding the relevant clinical trials is difficult and their results are only available in text-based reports. Systematic reviews aim to provide a comprehensive overview of the evidence in a specific area, but may not provide the data required for decision making. Methods We review and analyze the existing information systems and standards for aggregate level clinical trials information from the perspective of systematic review and evidence-based decision making. Results The technology currently used has major shortcomings, which cause deficiencies in the transfer, traceability and availability of clinical trials information. Specifically, data available to decision makers is insufficiently structured, and consequently the decisions cannot be properly traced back to the underlying evidence. Regulatory submission, trial publication, trial registration, and systematic review produce unstructured datasets that are insufficient for supporting evidence-based decision making. Conclusions The current situation is a hindrance to policy decision makers as it prevents fully transparent decision making and the development of more advanced decision support systems. Addressing the identified deficiencies would enable more efficient, informed, and transparent evidence-based medical decision making.

  16. A Note on the Observational Evidence for the Existence of Event Horizons in Astrophysical Black Hole Candidates

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    Cosimo Bambi

    2013-01-01

    Full Text Available Black holes have the peculiar and intriguing property of having an event horizon, a one-way membrane causally separating their internal region from the rest of the Universe. Today, astrophysical observations provide some evidence for the existence of event horizons in astrophysical black hole candidates. In this short paper, I compare the constraint we can infer from the nonobservation of electromagnetic radiation from the putative surface of these objects with the bound coming from the ergoregion instability, pointing out the respective assumptions and limitations.

  17. A note on the observational evidence for the existence of event horizons in astrophysical black hole candidates.

    Science.gov (United States)

    Bambi, Cosimo

    2013-01-01

    Black holes have the peculiar and intriguing property of having an event horizon, a one-way membrane causally separating their internal region from the rest of the Universe. Today, astrophysical observations provide some evidence for the existence of event horizons in astrophysical black hole candidates. In this short paper, I compare the constraint we can infer from the nonobservation of electromagnetic radiation from the putative surface of these objects with the bound coming from the ergoregion instability, pointing out the respective assumptions and limitations.

  18. Does Scientific Evidence for the Use of Natural Products in the Treatment of Oral Candidiasis Exist? A Systematic Review

    Directory of Open Access Journals (Sweden)

    Gabriela Lacet Silva Ferreira

    2015-01-01

    Full Text Available In view of the limitations of antifungal agents used in the treatment of oral candidiasis and the wide variety of natural products that have been studied as treatment of this disease, this systematic literature review proposed to evaluate whether scientific evidence attesting to the efficacy of natural products in the treatment of this disease exists. A systematic search in PubMed, MEDLINE, SciELO, Lilacs, and Cochrane Library databases was accomplished using the associations among the keywords Candida albicans, phytotherapy, biological products, denture stomatitis, and oral candidiasis in both English and Portuguese. Four independent observers evaluated the methodological quality of the resulting articles. Three studies were included for detailed analysis and evaluated according to the analysis protocol based on the CONSORT (Consolidated Standards of Reporting Trials 2010 statement. The tested products were different in all studies. Two studies mentioned random samples, but no study described the sample allocation. No study mentioned sample calculations, a prior pilot study, or examiner calibration, and only one trial reported sample losses. Differences between the tested products and the methodological designs among these studies did not allow the existence of scientific evidence related to the effectiveness of these products for the proposed subjects to be confirmed.

  19. Impacts of petroleum activities for the Achuar people of the Peruvian Amazon: summary of existing evidence and research gaps

    Science.gov (United States)

    Orta Martínez, Martí; Napolitano, Dora A.; MacLennan, Gregor J.; O'Callaghan, Cristina; Ciborowski, Sylvia; Fabregas, Xavier

    2007-10-01

    Petrol has been extracted from Achuar territory in the Northern Peruvian Amazon since the 1970s. In spite of early identification of negative impacts on the environment and repeated attempts by the Achuar to improve conditions, very little research has been done on specific environmental and health impacts. Some recent governmental studies have shown extremely high blood lead and cadmium levels in Achuar communities. In this paper we apply an environmental justice framework to review the evidence of pollution and health status available in existing studies, as well as government and operating company actions over the last 30 years. We identify gaps in our knowledge which hamper efforts to respond to the environmental and health situation, as well as negligent actions on the part of the State and petrol companies.

  20. Impacts of petroleum activities for the Achuar people of the Peruvian Amazon: summary of existing evidence and research gaps

    International Nuclear Information System (INIS)

    Martinez, Marti Orta; Napolitano, Dora A; MacLennan, Gregor J; O'Callaghan, Cristina; Ciborowski, Sylvia; Fabregas, Xavier

    2007-01-01

    Petrol has been extracted from Achuar territory in the Northern Peruvian Amazon since the 1970s. In spite of early identification of negative impacts on the environment and repeated attempts by the Achuar to improve conditions, very little research has been done on specific environmental and health impacts. Some recent governmental studies have shown extremely high blood lead and cadmium levels in Achuar communities. In this paper we apply an environmental justice framework to review the evidence of pollution and health status available in existing studies, as well as government and operating company actions over the last 30 years. We identify gaps in our knowledge which hamper efforts to respond to the environmental and health situation, as well as negligent actions on the part of the State and petrol companies

  1. Large dunes on the outer shelf off the Zambezi Delta, Mozambique: evidence for the existence of a Mozambique Current

    Science.gov (United States)

    Flemming, Burghard W.; Kudrass, Hermann-Rudolf

    2018-02-01

    studies comparing the application of slippage and non-slippage approaches—they suggest that, when applying partial slippage, a western boundary current can exist simultaneously with the southward migrating eddies. Considering the evidence presented in this paper, it is concluded that a quasi-persistent, though seasonally variable Mozambique Current does exist.

  2. No evidence for local adaptation to salt stress in the existing populations of invasive Solidago canadensis in China.

    Science.gov (United States)

    Li, Junmin; Liu, Haiyan; Yan, Ming; Du, Leshan

    2017-01-01

    Local adaptation is an important mechanism underlying the adaptation of plants to environmental heterogeneity, and the toxicity of salt results in strong selection pressure on salt tolerance in plants and different ecotypes. Solidago canadensis, which is invasive in China, has spread widely and has recently colonized alkali sandy loams with a significant salt content. A common greenhouse experiment was conducted to test the role of local adaptation in the successful invasion of S. canadensis into salty habitats. Salt treatment significantly decreased the growth of S. canadensis, including rates of increase in the number of leaves and plant height; the root, shoot, and total biomass. Furthermore, salt stress significantly reduced the net photosynthetic rate, stomatal conductance, transpiration rate and relative chlorophyll content but significantly increased peroxidase activity and the proline content of S. canadensis and the root/shoot ratio. Two-way analysis of variance showed that salt treatment had a significant effect on the physiological traits of S. canadensis, except for the intercellular CO2 concentration, whereas the population and the salt × population interaction had no significant effect on any physiological traits. Most of the variation in plasticity existed within and not among populations, excep for the root/shoot ratio. S. canadensis populations from soil with moderate/high salt levels grew similarly to S. canadensis populations from soils with low salt levels. No significant correlation between salt tolerance indices and soil salinity levels was observed. The plasticity of the proline content, intercellular CO2 concentration and chlorophyll content had significant correlations with the salt tolerance index. These findings indicate a lack of evidence for local adaption in the existing populations of invasive S. canadensis in China; instead, plasticity might be more important than local adaptation in influencing the physiological traits and salt

  3. No evidence for local adaptation to salt stress in the existing populations of invasive Solidago canadensis in China.

    Directory of Open Access Journals (Sweden)

    Junmin Li

    Full Text Available Local adaptation is an important mechanism underlying the adaptation of plants to environmental heterogeneity, and the toxicity of salt results in strong selection pressure on salt tolerance in plants and different ecotypes. Solidago canadensis, which is invasive in China, has spread widely and has recently colonized alkali sandy loams with a significant salt content. A common greenhouse experiment was conducted to test the role of local adaptation in the successful invasion of S. canadensis into salty habitats. Salt treatment significantly decreased the growth of S. canadensis, including rates of increase in the number of leaves and plant height; the root, shoot, and total biomass. Furthermore, salt stress significantly reduced the net photosynthetic rate, stomatal conductance, transpiration rate and relative chlorophyll content but significantly increased peroxidase activity and the proline content of S. canadensis and the root/shoot ratio. Two-way analysis of variance showed that salt treatment had a significant effect on the physiological traits of S. canadensis, except for the intercellular CO2 concentration, whereas the population and the salt × population interaction had no significant effect on any physiological traits. Most of the variation in plasticity existed within and not among populations, excep for the root/shoot ratio. S. canadensis populations from soil with moderate/high salt levels grew similarly to S. canadensis populations from soils with low salt levels. No significant correlation between salt tolerance indices and soil salinity levels was observed. The plasticity of the proline content, intercellular CO2 concentration and chlorophyll content had significant correlations with the salt tolerance index. These findings indicate a lack of evidence for local adaption in the existing populations of invasive S. canadensis in China; instead, plasticity might be more important than local adaptation in influencing the physiological

  4. Bridging existing governance gaps: five evidence-based actions that boards can take to pursue high quality care.

    Science.gov (United States)

    Leggat, Sandra G; Balding, Cathy

    2017-11-13

    Objective To explore the impact of the organisational quality systems on quality of care in Victorian health services. Methods During 2015 a total of 55 focus groups were conducted with more than 350 managers, clinical staff and board members in eight Victorian health services to explore the effectiveness of health service quality systems. A review of the quality and safety goals and strategies outlined in the strategic and operating plans of the participating health services was also undertaken. Results This paper focuses on the data related to the leadership role of health service boards in ensuring safe, high-quality care. The findings suggest that health service boards are not fully meeting their governance accountability to ensure consistently high-quality care. The data uncovered major clinical governance gaps between stated board and executive aspirations for quality and safety and the implementation of these expectations at point of care. These gaps were further compounded by quality system confusion, over-reliance on compliance, and inadequate staff engagement. Conclusion Based on the existing evidence we propose five specific actions boards can take to close the gaps, thereby supporting improved care for all consumers. What is known about this topic? Effective governance is essential for high-quality healthcare delivery. Boards are required to play an active role in their organisation's pursuit of high quality care. What does this paper add? Recent government reports suggest that Australian health service boards are not fully meeting their governance requirements for high quality, safe care delivery, and our research pinpoints key governance gaps. What are the implications for practitioners? Based on our research findings we outline five evidence-based actions for boards to improve their governance of quality care delivery. These actions focus on an organisational strategy for high-quality care, with the chief executive officer held accountable for

  5. Surgery for hepatic hidatidosis. Risk factors and variables associated with postoperative morbidity. Overview of the existing evidence.

    Science.gov (United States)

    Manterola, Carlos; Otzen, Tamara; Muñoz, Gloria; Alanis, Martín; Kruuse, Eileen; Figueroa, Gustavo

    2017-12-01

    There are few publications related to postoperative morbidity in hepatic hydatidosis and these have mixed results. The aim of this study was to determine risk and protective factors of postoperative morbidity in patients operated on for hepatic hydatidosis. A comprehensive review was made of the evidence, based on systematic reviews, clinical analyses and observational studies, obtained from the Trip Database, BVS, SciELO, Cochrane Central Register of Controlled Trials, WoS, MEDLINE, EMBASE, SCOPUS, EBSCOhost, IBECS, ePORTUGUESe, LILACS and WHOLIS. 1,087 related articles were identified; 69 fulfilled the selection criteria (2 systematic reviews, 3 clinical trials and 64 observational studies). Age, history of previous surgery for hepatic hydatidosis, location in the hepatic center, existence of biliary communications and evolutionary complications of the cyst were identified as risk factors, and radical surgical techniques as protective factors. Risk and protective factors were identified; however, the studies are few and the quality moderate to low. Copyright © 2017 AEC. Publicado por Elsevier España, S.L.U. All rights reserved.

  6. Gateway Effects: Why the Cited Evidence Does Not Support Their Existence for Low-Risk Tobacco Products (and What Evidence Would

    Directory of Open Access Journals (Sweden)

    Carl V. Phillips

    2015-05-01

    Full Text Available It is often claimed that low-risk drugs still create harm because of “gateway effects”, in which they cause the use of a high-risk alternative. Such claims are popular among opponents of tobacco harm reduction, claiming that low-risk tobacco products (e.g., e-cigarettes, smokeless tobacco cause people to start smoking, sometimes backed by empirical studies that ostensibly support the claim. However, these studies consistently ignore the obvious alternative causal pathways, particularly that observed associations might represent causation in the opposite direction (smoking causes people to seek low-risk alternatives or confounding (the same individual characteristics increase the chance of using any tobacco product. Due to these complications, any useful analysis must deal with simultaneity and confounding by common cause. In practice, existing analyses seem almost as if they were designed to provide teaching examples about drawing simplistic and unsupported causal conclusions from observed associations. The present analysis examines what evidence and research strategies would be needed to empirically detect such a gateway effect, if there were one, explaining key methodological concepts including causation and confounding, examining the logic of the claim, identifying potentially useful data, and debunking common fallacies on both sides of the argument, as well as presenting an extended example of proper empirical testing. The analysis demonstrates that none of the empirical studies to date that are purported to show a gateway effect from tobacco harm reduction products actually does so. The observations and approaches can be generalized to other cases where observed association of individual characteristics in cross-sectional data could result from any of several causal relationships.

  7. Evidence for the existence of Persian Gulf water and Red Sea water in the Bay of Bengal

    Digital Repository Service at National Institute of Oceanography (India)

    Jain, V.; Shankar, D.; Vinayachandran, P.N.; Kankonkar, A.; Chatterjee, A.; Amol, P.; Almeida, A.M.; Michael, G.S.; Mukherjee, A.; Chatterjee, M.; Fernandes, R.; Luis, R.; Kamble, A.; Hegde, A.; Chatterjee, S.; Das, U.; Neema, C.P.

    data from recent cruises to show that PGW and RSW also exist in the bay. The presence of RSW is marked by a deviation of the salinity vertical profile from a fitted curve at depths ranging from 500 to 1000 m; this deviation, though small (of the order...

  8. Evidence for the existence of Persian Gulf Water and Red Sea Water in the Bay of Bengal

    Science.gov (United States)

    Jain, Vineet; Shankar, D.; Vinayachandran, P. N.; Kankonkar, A.; Chatterjee, Abhisek; Amol, P.; Almeida, A. M.; Michael, G. S.; Mukherjee, A.; Chatterjee, Meenakshi; Fernandes, R.; Luis, R.; Kamble, Amol; Hegde, A. K.; Chatterjee, Siddhartha; Das, Umasankar; Neema, C. P.

    2017-05-01

    The high-salinity water masses that originate in the North Indian Ocean are Arabian Sea High-Salinity Water (ASHSW), Persian Gulf Water (PGW), and Red Sea Water (RSW). Among them, only ASHSW has been shown to exist in the Bay of Bengal. We use CTD data from recent cruises to show that PGW and RSW also exist in the bay. The presence of RSW is marked by a deviation of the salinity vertical profile from a fitted curve at depths ranging from 500 to 1000 m; this deviation, though small (of the order of 0.005 psu and therefore comparable to the CTD accuracy of 0.003 psu), is an order of magnitude larger than the 0.0003 psu fluctuations associated with the background turbulence or instrument noise in this depth regime, allowing us to infer the existence of RSW throughout the bay. PGW is marked by the presence of a salinity maximum at 200-450 m; in the southwestern bay, PGW can be distinguished from the salinity maximum due to ASHSW because of the intervening Arabian Sea Salinity Minimum. This salinity minimum and the maximum associated with ASHSW disappear east and north of the south-central bay (85°E, 8°N) owing to mixing between the fresher surface waters that are native to the bay (Bay of Bengal Water or BBW) with the high-salinity ASHSW. Hence, ASHSW is not seen as a distinct water mass in the northern and eastern bay and the maximum salinity over most of the bay is associated with PGW. The surface water over most of the bay is therefore a mixture of ASHSW and the low-salinity BBW. As a corollary, we can also infer that the weak oxygen peak seen within the oxygen-minimum zone in the bay at a depth of 250-400 m is associated with PGW. The hydrographic data also show that these three high-salinity water masses are advected into the bay by the Summer Monsoon Current, which is seen to be a deep current extending to 1000 m. These deep currents extend into the northern bay as well, providing a mechanism for spreading ASHSW, PGW, and RSW throughout the bay.

  9. Common RNA replication signals exist among group 2 coronaviruses: evidence for in vivo recombination between animal and human coronavius molecules

    International Nuclear Information System (INIS)

    Wu, H.-Y.; Guy, James S.; Yoo, Dongwan; Vlasak, Reinhard; Urbach, Ena; Brian, David A.

    2003-01-01

    5' and 3' UTR sequences on the coronavirus genome are known to carry cis-acting elements for DI RNA replication and presumably also virus genome replication. 5' UTR-adjacent coding sequences are also thought to harbor cis-acting elements. Here we have determined the 5' UTR and adjacent 289-nt sequences, and 3' UTR sequences, for six group 2 coronaviruses and have compared them to each other and to three previously reported group 2 members. Extensive regions of highly similar UTR sequences were found but small regions of divergence were also found indicating group 2 coronaviruses could be subdivided into those that are bovine coronavirus (BCoV)-like (BCoV, human respiratory coronavirus-OC43, human enteric coronavirus, porcine hemagglutinating encephalomyelitis virus, and equine coronavirus) and those that are murine hepatitis virus (MHV)-like (A59, 2, and JHM strains of MHV, puffinosis virus, and rat sialodacryoadenitis virus). The 3' UTRs of BCoV and MHV have been previously shown to be interchangeable. Here, a reporter-containing BCoV DI RNA was shown to be replicated by all five BCoV-like helper viruses and by MHV-H2 (a human cell-adapted MHV strain), a representative of the MHV-like subgroup, demonstrating group 2 common 5' and 3' replication signaling elements. BCoV DI RNA, furthermore, acquired the leader of HCoV-OC43 by leader switching, demonstrating for the first time in vivo recombination between animal and human coronavirus molecules. These results indicate that common replication signaling elements exist among group 2 coronaviruses despite a two-cluster pattern within the group and imply there could exist a high potential for recombination among group members

  10. Provider report of the existence of detection and care of perinatal depression: quantitative evidence from public obstetric units in Mexico

    Directory of Open Access Journals (Sweden)

    Filipa de Castro

    2016-07-01

    Full Text Available Objective. To provide evidence on perinatal mental healthcare in Mexico. Materials and methods. Descriptive and bivariate analyses of data from a cross-sectional probabilistic survey of 211 public obstetric units. Results. Over half (64.0% of units offer mental healthcare; fewer offer perinatal depression (PND detection (37.1% and care (40.3%. More units had protocols/guidelines for PND detection and for care, respectively, in Mexico City-Mexico state (76.7%; 78.1% than in Southern (26.5%; 36.4%, Northern (27.3%; 28.1% and Central Mexico (50.0%; 52.7%. Conclusion. Protocols and provider training in PND, implementation of brief screening tools and psychosocial interventions delivered by non-clinical personnel are needed.      DOI: http://dx.doi.org/10.21149/spm.v58i4.8028

  11. Provider report of the existence of detection and care of perinatal depression: quantitative evidence from public obstetric units in Mexico.

    Science.gov (United States)

    Castro, Filipa de; Place, Jean Marie; Allen-Leigh, Betania; Rivera-Rivera, Leonor; Billings, Deborah

    2016-08-01

    To provide evidence on perinatal mental healthcare in Mexico. Descriptive and bivariate analyses of data from a cross-sectional probabilistic survey of 211 public obstetric units. Over half (64.0%) of units offer mental healthcare; fewer offer perinatal depression (PND) detection (37.1%) and care (40.3%). More units had protocols/guidelines for PND detection and for care, respectively, in Mexico City-Mexico state (76.7%; 78.1%) than in Southern (26.5%; 36.4%), Northern (27.3%; 28.1%) and Central Mexico (50.0%; 52.7%). Protocols and provider training in PND, implementation of brief screening tools and psychosocial interventions delivered by non-clinical personnel are needed.

  12. Evidence from cosmic ray exposure (CRE) dating for the existence of a pre-Minoan caldera on Santorini, Greece

    Science.gov (United States)

    Athanassas, C. D.; Bourlès, D. L.; Braucher, R.; Druitt, T. H.; Nomikou, P.; Léanni, L.

    2016-05-01

    Cosmic ray exposure (CRE) dating was performed on the caldera cliffs of Santorini with the aim of detecting cliff segments predating the Minoan eruption (17th century BCE). The methodology involved the determination of in situ-produced cosmogenic 36Cl concentration in basaltic-to-rhyodacitic whole rocks cropping out in the cliffs. After the samples were processed following the chemical protocol of 36Cl preparation for silicate rocks, 36Cl concentrations were measured by accelerator mass spectrometry (AMS). Important challenges during the implementation procedure were related to large amounts of radiogenic 36Cl, complex modeling of inherited 36Cl, and dominance of the thermal and epithermal (low-energy) neutron capture production pathway. Nevertheless, quantitative assessments on the basis of the contribution of the low-energy neutron capture pathway percent to the total production rate validated the calculated CRE dates. Current CRE ages demonstrate that an ancient caldera existed on pre-Minoan Santorini, occupying at least the northern half of the modern-day caldera.

  13. Transcriptome mining and in silico structural and functional analysis of ascorbic acid and tartaric acid biosynthesis pathway enzymes in rose-scanted geranium.

    Science.gov (United States)

    Narnoliya, Lokesh K; Sangwan, Rajender S; Singh, Sudhir P

    2018-06-01

    Rose-scented geranium (Pelargonium sp.) is widely known as aromatic and medicinal herb, accumulating specialized metabolites of high economic importance, such as essential oils, ascorbic acid, and tartaric acid. Ascorbic acid and tartaric acid are multifunctional metabolites of human value to be used as vital antioxidants and flavor enhancing agents in food products. No information is available related to the structural and functional properties of the enzymes involved in ascorbic acid and tartaric acid biosynthesis in rose-scented geranium. In the present study, transcriptome mining was done to identify full-length genes, followed by their bioinformatic and molecular modeling investigations and understanding of in silico structural and functional properties of these enzymes. Evolutionary conserved domains were identified in the pathway enzymes. In silico physicochemical characterization of the catalytic enzymes revealed isoelectric point (pI), instability index, aliphatic index, and grand average hydropathy (GRAVY) values of the enzymes. Secondary structural prediction revealed abundant proportion of alpha helix and random coil confirmations in the pathway enzymes. Three-dimensional homology models were developed for these enzymes. The predicted structures showed significant structural similarity with their respective templates in root mean square deviation analysis. Ramachandran plot analysis of the modeled enzymes revealed that more than 84% of the amino acid residues were within the favored regions. Further, functionally important residues were identified corresponding to catalytic sites located in the enzymes. To, our best knowledge, this is the first report which provides a foundation on functional annotation and structural determination of ascorbic acid and tartaric acid pathway enzymes in rose-scanted geranium.

  14. An analysis of dinosaurian biogeography: evidence for the existence of vicariance and dispersal patterns caused by geological events.

    Science.gov (United States)

    Upchurch, Paul; Hunn, Craig A; Norman, David B

    2002-03-22

    As the supercontinent Pangaea fragmented during the Mesozoic era, dinosaur faunas were divided into isolated populations living on separate continents. It has been predicted, therefore, that dinosaur distributions should display a branching ('vicariance') pattern that corresponds with the sequence and timing of continental break-up. Several recent studies, however, minimize the importance of plate tectonics and instead suggest that dispersal and regional extinction were the main controls on dinosaur biogeography. Here, in order to test the vicariance hypothesis, we apply a cladistic biogeographical method to a large dataset on dinosaur relationships and distributions. We also introduce a methodological refinement termed 'time-slicing', which is shown to be a key step in the detection of ancient biogeographical patterns. These analyses reveal biogeographical patterns that closely correlate with palaeogeography. The results provide the first statistically robust evidence that, from Middle Jurassic to mid-Cretaceous times, tectonic events had a major role in determining where and when particular dinosaur groups flourished. The fact that evolutionary trees for extinct organisms preserve such distribution patterns opens up a new and fruitful direction for palaeobiogeographical research.

  15. Electrophysiological and pharmacological evidence for the existence of distinct subpopulations of nigrostriatal dopaminergic neuron in the rat.

    Science.gov (United States)

    Shepard, P D; German, D C

    1988-11-01

    The electrophysiological and pharmacological properties of dopaminergic neurons were systematically examined throughout the anterior-posterior extent of the substantia nigra zona compacta in the rat. Cells were characterized in terms of their (1) firing pattern, (2) firing rate, (3) antidromic response properties, and (4) inhibition in firing rate following dopaminergic agonist administration. These properties were then related to the cell's position within one of four anterior-posterior segments of the nucleus. There were three types of neuronal discharge pattern encountered; irregular, burst and regular. Cells which exhibited different firing patterns exhibited different firing rates and anatomical locations within the substantia nigra zona compacta. All neurons were antidromically activated from the striatum, however, the burst- and regular-firing cells exhibited significantly faster estimated conduction velocities than irregular-firing cells. The irregular-firing cells were most sensitive to dopaminergic autoreceptor agonists whereas the burst-firing cells were most sensitive to an indirect-acting dopaminergic agonist. These experiments provide both electrophysiological and pharmacological evidence to indicate that nigrostriatal dopaminergic neurons are composed of distinct subpopulations which are characterized by their firing pattern.

  16. What evidence exists for new strategies or technologies in the diagnosis of sports concussion and assessment of recovery?

    Science.gov (United States)

    Kutcher, Jeffrey Scott; McCrory, Paul; Davis, Gavin; Ptito, Alain; Meeuwisse, Willem H; Broglio, Steven P

    2013-04-01

    The purpose of this critical review is to summarise the evidence for the following technologies/strategies related to diagnosing or managing sports-related concussion: quantitative EEG, functional neuroimaging, head impact sensors, telemedicine and mobile devices. MEDLINE, PubMed, Cochrane Controlled Trials Registers, SportDiscus, EMBASE, Web of Science and ProQuest databases. Primary search keywords were concussion, sports concussion and mild traumatic brain injury. The keywords used for secondary, topic specific searches were quantitative electroencephalography, qEEG, functionalMRI, magnetoencephalography, near-infrared spectroscopy, positron emission tomography, single photon emissionCT, accelerometer, impact sensor, telemetry, remote monitoring, robotic medicine, telemedicine, mobile device, mobile phone, smart phone and tablet computer. The primary search produced 8567 publications. The secondary searches produced nine publications that presented original data, included a comparison group in the study design and involved sports-related concussion. Four studies spoke to the potential of qEEG as a diagnostic or management tool, while five studies addressed the potential of fMRI to be used in the same capacity. Emerging technologies and novel approaches that aid in sports concussion diagnosis and management are being introduced at a rapid rate. While some technologies show promise, their clinical utility remains to be established.

  17. Acupuncture and vitamin B12 injection for Bell′s palsy: no high-quality evidence exists

    Directory of Open Access Journals (Sweden)

    Li-li Wang

    2015-01-01

    MAIN OUTCOME MEASURES: Incomplete recovery rates were chosen as the primary outcome. RESULTS: Five studies involving 344 patients were included in the final analysis. Results showed that the incomplete recovery rate of Bell′s palsy patients was 44.50% in the acupuncture combined with vitamin B 12 group but 62.57% in the acupuncture alone group. The major acupoints were Taiyang (EX-HN5, Jiache (ST6, Dicang (ST4 and Sibai (ST2. The combined effect size showed that acupuncture combined with vitamin B 12 was better than acupuncture alone for the treatment of Bell′s palsy (RR = 0.71, 95%CI: 0.58-0.87; P = 0.001, this result held true when 8 patients lost to follow up in one study were included into the analyses (RR = 0.70, 95%CI: 0.58-0.86; P = 0.0005. In the subgroup analyses, the therapeutic effect in patients of the electroacupuncture subgroup was better than in the non-electroacupuncture subgroup (P = 0.024. There was no significant difference in the incomplete recovery rate by subgroup analysis on drug types and treatment period. Most of the included studies were moderate or low quality, and bias existed. CONCLUSION: In patients with Bell′s palsy, acupuncture combined with vitamin B 12 can reduce the risk of incomplete recovery compared with acupuncture alone in our meta-analysis. Because of study bias and methodological limitations, this conclusion is uncertain and the clinical application of acupuncture combined with vitamin B 12 requires further exploration.

  18. Lymphoscintigraphy of a patient with secondary leg lymphoedema provides evidence for the existence of axillo-inguinal anastomotic pathways

    International Nuclear Information System (INIS)

    Peter, D.T.; Piller, N.B.; Goodear, M.

    1999-01-01

    Full text: The aim of treatment for lymphoedema is to open collateral pathways to allow lymph to pass any blocked or restricted region and to move across watershed areas. These areas and drainage territories have been postulated by Foldi and Kubic. Some groups have stated that in over 400 lymphoscintigrams they have not been able to corroborate tracer collateral pathways. However, we have been able to demonstrate the existence of axillo-inguinal anastomotic pathways. A 37-year-old female presented with leg oedema subsequent to a total abdominal hysterectomy and radiotherapy Lymphoscintigraphy was requested to assess lymphatic drainage of both legs to assist optimization of treatment. 99 Tc m -antimony trisulphide colloid was injected at each of four sites intra-dermally, in the first inter-digital space and latero-dorsal areas of each foot. Anterior images, these being from the feet to above the liver, were then performed at 40, 85, 180 and 307 min post-injection. From 40 min, and continuing throughout the study, isotope distribution representing dermal diffusion was seen throughout both limbs up to and including the pelvic area. Tracer was first observed in the axillary region at 85 min and at that time clear superficial anastomotic pathways were observable. The axillary nodes continued to appear throughout the rest of the study. As important as it was to localize the areas of dermal diffusion and lymphatic pathways in the lower limbs, the most significant discovery in this instance was the confirmation of the axillo-inguinal anastomotic pathways previously postulated by Foldi and Kubic. This should help to increase the confidence of those professionals involved in the treatment of lymphoedema

  19. Evidence for the Existence of Triple-Negative Variants in the MCF-7 Breast Cancer Cell Population

    Directory of Open Access Journals (Sweden)

    Euphemia Leung

    2014-01-01

    Full Text Available The MCF-7 line, derived in 1973 from a malignant pleural effusion, is one of the most commonly used culture models for human breast cancer. Despite its long history, MCF-7 is a surprisingly heterogeneous line. We previously showed that if MCF-7 cells were cultured for a prolonged period either in the absence of estrogen or in the presence of the antiestrogen tamoxifen, sub-lines were selected that differed from the parental line in ploidy, mean cell volume, signaling pathway usage, and drug sensitivity. This suggests a process of selection of preexisting variants rather than of adaptation of the parental line. All the sublines were estrogen receptor (ER positive, raising the question of whether MCF-7 also contains ER negative variants. Here, we have looked for such variants by culturing for a prolonged period in the presence of fulvestrant, an estrogen antagonist that has no estrogen agonist activity. Three sublines were developed, each of which was ER negative, progesterone receptor (PR negative and expressed only a low level of HER2. Each of the variants differed from the original MCF-7 line in ploidy, modal cell volume, and signaling pathway usage. Control experiments in which cells were cultured for a prolonged period in the absence of estrogen selected for variants that were ER and PR positive. The properties of the triple-negative MCF-7 were compared with those of an existing triple-negative cell line, MDA-MB-231, and human epidermal growth factor receptor 2 (HER2+ SKBr3, as well as from those of the “immortalized” breast epithelial line MCF10A. The results suggest that new variants or phenotypes of MCF-7 might be generated continuously in culture, and by implication this might apply to breast cancer development and even normal breast epithelial development in vivo.

  20. Further evidence for the existence of environmental and host-associated species of coagulase-negative staphylococci in dairy cattle.

    Science.gov (United States)

    De Visscher, Anneleen; Supré, Karlien; Haesebrouck, Freddy; Zadoks, Ruth N; Piessens, Veerle; Van Coillie, Els; Piepers, Sofie; De Vliegher, Sarne

    2014-08-27

    Coagulase-negative staphylococci (CNS) are abundantly present in the dairy farm environment and on bovine skin and mucosae. They are also the most prevalent bacteria causing bovine intramammary infections (IMI). Reservoirs and transmission routes of CNS are not yet fully unraveled. The objectives of this study were to explore the distribution of CNS in parlor-related extramammary niches and to compare it to the distributions of CNS causing IMI in those herds. Niches that were targeted in this study were cows' teat apices, milking machine unit liners, and milker's skin or gloves. Each of the three herds had its own CNS microbiota in those niches. The most prevalent species in the parlor-related extramammary niches were Staphylococcus cohnii, S. fleurettii, and S. equorum in the first, second, and third herd, respectively, whereas S. haemolyticus and S. sciuri were found in all herds. S. cohnii and S. fleurettii, as well as S. haemolyticus, which was present in each herd, were also frequently found in milk samples. By contrast, S. chromogenes, S. simulans, and S. xylosus favored the mammary gland, whereas S. equorum was more common in the parlor-associated niches. Within each herd, species distribution was similar between teat apices and milking machine unit liners. In conclusion, some of the extramammary niches related to the milking process might act as infection sources for IMI-causing CNS. This study provides further evidence that the group of CNS species is comprised of environmental, opportunistic and host-adapted species which differ in ecology. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. Do purely capital layers exist among flying birds? Evidence of exogenous contribution to arctic-nesting common eider eggs.

    Science.gov (United States)

    Sénéchal, Edith; Bêty, Joël; Gilchrist, H Grant; Hobson, Keith A; Jamieson, Sarah E

    2011-03-01

    The strategy of relying extensively on stored resources for reproduction has been termed capital breeding and is in contrast to income breeding, where needs of reproduction are satisfied by exogenous (dietary) resources. Most species likely fall somewhere between these two extremes, and the position of an organism along this gradient can influence several key life-history traits. Common eiders (Somateria mollissima) are the only flying birds that are still typically considered pure capital breeders, suggesting that they depend exclusively on endogenous reserves to form their eggs and incubate. We investigated the annual and seasonal variation in contributions of endogenous and exogenous resources to egg formation in eiders breeding at the East Bay colony in the Canadian Arctic. We collected prey items along with females and their eggs during various stages of breeding and used two complementary analytical approaches: body reserve dynamics and stable isotope [δ(13)C, δ(15)N] mixing models. Indices of protein reserves remained stable from pre-laying to post-laying stages, while lipid reserves declined significantly during laying. Similarly, stable isotope analyses indicated that (1) exogenous nutrients derived from marine invertebrates strongly contributed to the formation of lipid-free egg constituents, and (2) yolk lipids were constituted mostly from endogenous lipids. We also found evidence of seasonal variation in the use of body reserves, with early breeders using proportionally more exogenous proteins to form each egg than late breeders. Based on these results, we reject the hypothesis that eiders are pure capital layers. In these flying birds, the fitness costs of a strict capital breeding strategy, such as temporary loss of flight capability and limitation of clutch and egg size, may outweigh benefits such as a reduction in egg predation rate.

  2. Connection of the Late Paleolithic archaeological sites of the Chuya depression with geological evidence of existence of the Late Pleistocene ice-dammed lakes

    Science.gov (United States)

    Agatova, A. R.; Nepop, R. K.

    2017-07-01

    The complexity of the age dating of the Pleistocene ice-dammed paleolakes in the Altai Mountains is a reason why geologists consider the Early Paleolithic archaeological sites as an independent age marker for dating geological objects. However, in order to use these sites for paleogeographic reconstructions, their locations, the character of stratification, and the age of stone artifacts need to be comprehensively studied. We investigate 20 Late Paleolithic archaeological sites discovered in the Chuya depression of the Russian Altai (Altai Mountains) with the aim of their possible use for reconstructions of the period of development of the Kurai-Chuya glacio-limnosystem in the Late Neopleistocene. The results of our investigation show that it is improper to use the Paleolithic archaeological sites for the dating of the existence period and the draining time of ice-dammed lakes of the Chuya Depression in the modern period of their study owing to a lack of quantitative age estimates, a wide age range of possible existence of these sites, possible redeposition of the majority of artifacts, and their surface occurrence. It is established that all stratified sites where cultural layers are expected to be dated in the future lie above the uppermost and well-expressed paleolake level (2100 m a.s.l.). Accordingly, there are no grounds to determine the existence time of shallower paleolakes. Since the whole stone material collected below the level of 2100 m a.s.l. is represented by surface finds, it is problematic to use these artifacts for absolute geochronology. The Late Paleolithic Bigdon and Chechketerek sites are of great interest for paleogeographic reconstructions of ice-dammed lakes. The use of iceberg rafting products as cores is evidence that these sites appeared after the draining of a paleolake (2000 m a.s.l.). At this time, the location of these archaeological sites on the slope of the Chuya Depression allows one to assume the existence of a large lake as deep

  3. What can we learn from the existing evidence of the business case for investments in nursing care: importance of content, context, and policy environment.

    Science.gov (United States)

    Yakusheva, Olga; Wholey, Douglas; Frick, Kevin D

    2013-04-01

    Decisions of health care institutions to invest in nursing care are often guided by mixed and conflicting evidence of effects of the investments on organizational function and sustainability. This paper uses new evidence generated through Interdisciplinary Nursing Quality Research Initiative (INQRI)-funded research and published in peer-reviewed journals, to illustrate where the business case for nursing investments stands and to discuss factors that may limit the existing evidence and its transferability into clinical practice. We conclude that there are 3 limiting factors: (1) the existing business case for nursing investments is likely understated due to the inability of most studies to capture spillover and long-run dynamic effects, thus causing organizations to forfeit potentially viable nursing investments that may improve long-term financial stability; (2) studies rarely devote sufficient attention to describing the content and the organization-specific contextual factors, thus limiting generalizability; and (3) fragmentation of the current health care delivery and payment systems often leads to the financial benefits of investments in nursing care accruing outside of the organization incurring the costs, thus making potentially quality-improving and cost-saving interventions financially unattractive from the organization's perspective. The payment reform, with its emphasis on high-quality affordable patient-centered care, is likely to strengthen the business case for investments in nursing care. Methodologically rigorous approaches that focus on broader societal implications of investments in nursing care, combined with a thorough understanding of potential barriers and facilitators of nursing change, should be an integral part of future research and policy efforts.

  4. Revitalising Evidence-based Policy for the Sendai Framework for Disaster Risk Reduction 2015-2030: Lessons from Existing International Science Partnerships.

    Science.gov (United States)

    Carabine, Elizabeth

    2015-04-23

    The convergence of agreements on disaster risk reduction (DRR), development finance, sustainable development and climate change in 2015 presents a unique opportunity for coherence across these inter-related policy areas. At the same time, demand is growing for a more prominent and effective role for science and technology in providing evidence for policy, with the international community recognising that successful disaster risk reduction (DRR) depends on it. Reflecting this ambition, science is included as a core aspect of the Sendai Framework for Disaster Risk Reduction 2015-2030, although the ways in which this will be implemented in practice is still unclear. This paper aims to inform the implementation of international science coordination for DRR by examining a number of existing international science partnerships used across other relevant areas of policy to understand best practice, options for coordination and lessons identified. In the field of DRR, the science-policy interface needs to be strengthened in line with the best practice described in this review. An enhanced UNISDR Scientific and Technical Advisory Group will be given the mandate for to enhance the evidence base for DRR and mobilise science and technical work in coordination with a broad range of stakeholders. The structure and function of an enhanced STAG must be as open, as inclusive and as participatory as possible in order to build trust in new and existing institutions at local, national, regional and global levels. The challenge for the international community is to facilitate evidence-based policy making by formally recognising the links between DRR, development finance, sustainable development and climate change in the upcoming post-2015 agreements.

  5. Mass spectrometric and enzymatic evidence confirm the existence of anthocyanidin 3,5-O-diglucosides in cabernet sauvignon (Vitis vinifera L.) grape berries.

    Science.gov (United States)

    Xing, Ran-Ran; Li, Si-Yu; He, Fei; Yang, Zhe; Duan, Chang-Qing; Li, Zheng; Wang, Jun; Pan, Qiu-Hong

    2015-04-01

    It has been widely accepted that anthocyanidin 3,5-O-diglucosides do not exist in Vitis vinifera L. Cabernet Sauvignon (CS) berries. However, our anthocyanin analyses using HPLC-ESI-MS/MS detected the existence of a low level of anthocyanidin 3,5-O-diglucosides in the Cabernet Sauvignon grape berries grown in China. The authenticity of these samples was confirmed with microsatellite markers. The existence of anthocyanidin 3,5-O-diglucoside was further verified by the enzymatic evidence for the first time. Four putative 5-O-glucosyltransferase (5GT) genes were isolated from the Cabernet Sauvignon berries. The enzymatic analysis showed that a recombinant protein (designated as Vv5GT3) glucosylated the 3-O- and 5-O-positions of anthocyanidins and flavonols. A phylogenetic analysis revealed that this bifunctional enzyme belongs to the 5GT subfamily of UDP-glycosyltransferases. This finding brought a new understanding of the anthocyanins' profile and their biosynthesis in V. vinifera and would be helpful for further investigations of the mechanism of accumulation of anthocyanidin diglucosides in Cabernet Sauvignon berries in China's wine-producing regions.

  6. What is the existing evidence supporting the efficacy of compression bandage systems containing both elastic and inelastic components (mixed-component systems)? A systematic review.

    Science.gov (United States)

    Welsh, Lynn

    2017-05-01

    To analyse current evidence on the efficacy of bandage systems containing both elastic and inelastic components (mixed-component systems). International consensus on the efficacy of types of compression systems is difficult to achieve; however, mixed-component systems are being promoted as combining the best properties of both elastic and inelastic bandage systems and increasingly being used to treat venous leg ulcers in practice. A systematic literature review. Search terms such as venous leg ulcer, varicose ulcer, leg ulcer, compression, bandage, elastic, inelastic, short stretch, healing rate, interface pressure, mixed component, two-layer, four-layer and multi-layer were used in database and hand searches in several combinations. Limits were set for years 2005-March 2015 and English-language publications. A total of 475 studies were identified at initial search, and following elimination from abstract and title, this was reduced to 7. A further study was identified on Google Scholar, bringing the final number of studies fitting inclusion criteria to 8. The following subgroups relating to outcomes of efficacy were identified: ulcer healing, maintenance of interface pressure, slippage, ease of application and patient quality of life. Mixed-component systems were found to have comparable ulcer healing rates to alternative compression systems and be easy to apply; have similar abilities to maintain pressure as four-layer bandages and better abilities than short-stretch bandages; have less slippage than alternative systems; and to be significantly associated with several favourable quality of life outcomes. Clinician skill in bandage application was an uncontrolled variable in all eight papers included in the review, which may limit reliability of findings. This review synthesises existing evidence on the efficacy of mixed-component systems and encourages clinicians to regard them as an effective alternative to purely elastic or inelastic compression systems

  7. Chemotaxis and degradation of organophosphate compound by a novel moderately thermo-halo tolerant Pseudomonas sp. strain BUR11: evidence for possible existence of two pathways for degradation

    Directory of Open Access Journals (Sweden)

    Santanu Pailan

    2015-11-01

    Full Text Available An organophosphate (OP degrading chemotactic bacterial strain BUR11 isolated from an agricultural field was identified as a member of Pseudomonas genus on the basis of its 16S rRNA gene sequence. The strain could utilize parathion, chlorpyrifos and their major hydrolytic intermediates as sole source of carbon for its growth and exhibited positive chemotactic response towards most of them. Optimum concentration of parathion for its growth was recorded to be 200 ppm and 62% of which was degraded within 96 h at 37 °C. Growth studies indicated the strain to be moderately thermo-halo tolerant in nature. Investigation based on identification of intermediates of parathion degradation by thin layer chromatography (TLC, high performance liquid chromatography (HPLC, gas chromatography (GC and liquid chromatography mass spectrometry (LC-MS/MS provided evidence for possible existence of two pathways. The first pathway proceeds via 4-nitrophenol (4-NP while the second proceeds through formation of 4-aminoparathion (4-APar, 4-aminophenol (4-AP and parabenzoquinone (PBQ. This is the first report of chemotaxis towards organophosphate compound by a thermo-halo tolerant bacterium.

  8. Evident?

    DEFF Research Database (Denmark)

    Plant, Peter

    2012-01-01

    Quality assurance and evidence in career guidance in Europe are often seen as self-evident approaches, but particular interests lie behind......Quality assurance and evidence in career guidance in Europe are often seen as self-evident approaches, but particular interests lie behind...

  9. Life and death of the resurrection plate: Evidence for its existence and subduction in the northeastern Pacific in Paleocene-Eocene time

    Science.gov (United States)

    Haeussler, P.J.; Bradley, D.C.; Wells, R.E.; Miller, M.L.

    2003-01-01

    Onshore evidence suggests that a plate is missing from published reconstructions of the northeastern Pacific Ooean in Paleocene- Eocene time. The Resurrection plate, named for the Resurrection Peninsula ophiolite near Seward, Alaska, was located east of the Kula plate and north of the Farallon plate. We interpret coeval near-trench magmatism in southern Alaska and the Cascadia margin as evidence for two slab windows associated with trench-ridge-trench (TRT) triple junctions, which formed the western and southern boundaries of the Resurrection plate. In Alaska, the Sanak-Baranof belt of near-trench intrusions records a west-to-east migration, from 61 to 50 Ma, of the northern TRT triple junction along a 2100-km-long section of coastline. In Oregon, Washington, and southern Vancouver Island, voluminous basaltic volcanism of the Siletz River Volcanics, Crescent Formation, and Metchosin Volcanics occurred between ca. 66 and 48 Ma. Lack of a clear age progression of magmatism along the Cascadia margin suggests that this southern triple junction did not migrate significantly. Synchronous near-trench magmatism from southeastern Alaska to Puget Sound at ca. 50 Ma documents the middle Eocene subduction of a spreading center, the crest of which was subparallel to the margin. We interpret this ca. 50 Ma event as recording the subduction-zone consumption of the last of the Resurrection plate. The existence and subsequent subduction of the Resurrection plate explains (1) northward terrane transport along the southeastern Alaska-British Columbia margin between 70 and 50 Ma, synchronous with an eastward-migrating triple junction in southern Alaska; (2) rapid uplift and voluminous magmatism in the Coast Mountains of British Columbia prior to 50 Ma related to subduction of buoyant, young oceanic crust of the Resurrection plate; (3) cessation of Coast Mountains magmatism at ca. 50 Ma due to cessation of subduction, (4) primitive mafic magmatism in the Coast Mountains and Cascade

  10. Permafrost at its limits: The most easterly evidence of existing permafrost in the European Alps as indicated by ground temperature and geoelectrical measurements

    Science.gov (United States)

    Kellerer-Pirklbauer, A.; Kühnast, B.

    2009-04-01

    ). In contrast, at the lower part of the talus slope the permafrost body is most likely very thin (less than 1 m) whereas at the uppermost part permafrost is absent. Generally, the permafrost distribution seems to be strongly influenced by the grain size of the sediments at the study site. The ERT data are in accordance with the collected temperature data supporting that this site is the most easterly evidence of existing permafrost found in the entire European Alps at 14°41'E.

  11. Virtuous States and Virtuous Traits: How the Empirical Evidence Regarding the Existence of Broad Traits Saves Virtue Ethics from the Situationist Critique

    Science.gov (United States)

    Jayawickreme, Eranda; Meindl, Peter; Helzer, Erik G.; Furr, R. Michael; Fleeson, William

    2014-01-01

    A major objection to the study of virtue asserts that the empirical psychological evidence implies traits have little meaningful impact on behavior, as slight changes in situational characteristics appear to lead to large changes in virtuous behavior. We argue in response that the critical evidence is not these effects of situations observed in…

  12. Two forms of acid alpha-D-mannosidase in monkey brain: evidence for the co-existence of high mannose and complex oligosaccharides in one form.

    Science.gov (United States)

    Mathur, R; Alvares, K; Balasubramanian, A S

    1984-09-28

    Lysosomal alpha-D-mannosidase of monkey brain existed in two forms. One form of mannosidase was bound to the Ricinus communis agglutinin120 (RCA1)-Sepharose and could be specifically eluted with lactose. The other form did not bind to the RCA1-Sepharose. Both forms of mannosidase could bind to a similar extent to the immobilized brain lysosomal receptor protein. Both the forms were purified to apparent homogeneity. Neutral sugar analysis by GLC showed the presence of glucose, mannose and galactose in the RCA1-Sepharose bindable mannosidase and glucose and mannose in the non-bindable mannosidase. Several other brain lysosomal hydrolases did not bind to the RCA1-Sepharose. The results suggested the existence of only high mannose oligosaccharides in the RCA1 non-bindable mannosidase and both high mannose and complex oligosaccharides in the bindable mannosidase.

  13. Antimutagenic action of aminoacids on UV-irradiated E. Coli cells: evidence of the existence of metabolic regulation of antimutagenic activity

    International Nuclear Information System (INIS)

    Filippov, V.D.

    1990-01-01

    The yield of mutations in Escherichia Coli cells placed after UV irradiation in a glucose-free salt medium enriched with casamino acids was determined. It is shown that in the absence of glucose casamino acids and certain individual amino acids produce a strong antimutagenetic effect. The acquired data allow to assume the existence of fine metabolic regulation of mutation reparation processes and occurrence of mutations in E. Coli cells exposed to UV-radiation

  14. Does Sufficient Evidence Exist to Support a Causal Association between Vitamin D Status and Cardiovascular Disease Risk? An Assessment Using Hill’s Criteria for Causality

    OpenAIRE

    Weyland, Patricia G.; Grant, William B.; Howie-Esquivel, Jill

    2014-01-01

    Serum 25-hydroxyvitamin D (25(OH)D) levels have been found to be inversely associated with both prevalent and incident cardiovascular disease (CVD) risk factors; dyslipidemia, hypertension and diabetes mellitus. This review looks for evidence of a causal association between low 25(OH)D levels and increased CVD risk. We evaluated journal articles in light of Hill’s criteria for causality in a biological system. The results of our assessment are as follows. Strength of association: many randomi...

  15. Is There Any Evidence on the Existence of an Environmental Taxation Kuznets Curve? The Case of European Countries under Their Rule of Law Enforcement

    Directory of Open Access Journals (Sweden)

    Concetta Castiglione

    2014-10-01

    Full Text Available The paper gives new insights into the environmental taxation policy, demonstrating the existence of an inverse U-shaped relationship between environmental taxation and income in European countries. Our findings reveal this relationship to be influenced by enforcement of the rule of law, which contributes to shifting the turning point on the curve to lower income levels. We show that former transition economies have not reached the turning point due to weak institutions. To achieve the goal of sustainable development, the European Environment Agency’s Environmental Taxation Reform, proposing to shift taxation from “goods” to “bads”, should be accompanied by effective enforcement or the rule of law. The heterogeneity found between market-based and former transition European countries demonstrates the existence of problems at the EU-level in the coordination of environmental policies and enforcing the rule of law. In addition, the analysis of the determinants of environmental taxation points to the importance of factors related to consumption and production, governance, environmental quality, oil price shocks and the shift of environmental policy in European countries.

  16. Subduction Initiation Existed Along the Ancient Continent Margins? Evidence of U-Pb ages of zircons from the Bonin Trench, Japan

    Science.gov (United States)

    Li, Y. B.; Pearce, J. A.; Ryan, J. G.; Li, X. H.; Haraguchi, S.; Iizuka, T.; Kon, Y.; Yamamoto, S.; Sawaki, Y.; Ishii, T.; Maruyama, S.

    2017-12-01

    Although it is not cleanly known when and where the subduction initiation began on the Paleo-Izu-Bonin-Mariana (IBM) Trench, Jurassic and Cretaceous plutonic rocks, such as gabbroic, granitic and metamorphic rocks had been sampled from the Amami Plateau-Daito Ridge-Okidaito Ridge (ADO) in the Philippine Sea Plate. Furthermore, Mesozonic to Paleozonic ages zircons were obtained from volcaniclastic sandstones collected from northern Izu-Bonin forarc (Tani et al., 2012). We present U-Pb ages, Hf-O isotopes and trace element compositions of zircon grains separated from sediment, volcanic rock, dolerite and gabbro, collected from Chichijima Island and Bonin forearc seafloor (KH03-3, KT04-28 cruise of the University of Tokyo, IODP Leg 352). In the zircon age histogram, several age groups were identified. The age peaks are 0-3 Ma and 13 Ma (Hahajima Seamount: soft mud and volcanic tuff); 38 Ma (Oomachi Seamount: sandstone); 45 Ma (Chichijima Island: volcanic rock); 40 Ma, 48 Ma and 52 Ma (Hahajima Seamount: dolerite and gabbro); 45 Ma and 164-165 Ma (IODP Leg 352: volcanic rock), respectively. Zircon U-Pb ages ranging 0-52 Ma correspond well to the multi-stages of magmatism in the IBM. However, 164-165 Ma maybe represent the ages of zircon xenocryst including in forearc volcanic rock , which pre-existing in ancient continent crustal materials (SE China Continent Crust?) as the basement of Paleo-IBM. It seems reasonable to suppose that the subduction initiation of IBM existed along the ancient SE China Continent margins. The initiation of subduction zone is a consequence of lateral compositional buoyancy contrast within the lithosphere, that advocated by Niu et al. (2003, 2016).

  17. The evolution of a Late Cretaceous-Cenozoic intraplate basin (Duaringa Basin), eastern Australia: evidence for the negative inversion of a pre-existing fold-thrust belt

    Science.gov (United States)

    Babaahmadi, Abbas; Sliwa, Renate; Esterle, Joan; Rosenbaum, Gideon

    2017-12-01

    The Duaringa Basin in eastern Australia is a Late Cretaceous?-early Cenozoic sedimentary basin that developed simultaneously with the opening of the Tasman and Coral Seas. The basin occurs on the top of an earlier (Permian-Triassic) fold-thrust belt, but the negative inversion of this fold-thrust belt, and its contribution to the development of the Duaringa Basin, are not well understood. Here, we present geophysical datasets, including recently surveyed 2D seismic reflection lines, aeromagnetic and Bouguer gravity data. These data provide new insights into the structural style in the Duaringa Basin, showing that the NNW-striking, NE-dipping, deep-seated Duaringa Fault is the main boundary fault that controlled sedimentation in the Duaringa Basin. The major activity of the Duaringa Fault is observed in the southern part of the basin, where it has undergone the highest amount of displacement, resulting in the deepest and oldest depocentre. The results reveal that the Duaringa Basin developed in response to the partial negative inversion of the pre-existing Permian-Triassic fold-thrust belt, which has similar orientation to the extensional faults. The Duaringa Fault is the negative inverted part of a single Triassic thrust, known as the Banana Thrust. Furthermore, small syn-depositional normal faults at the base of the basin likely developed due to the reactivation of pre-existing foliations, accommodation faults, and joints associated with Permian-Triassic folds. In contrast to equivalent offshore basins, the Duaringa Basin lacks a complex structural style and thick syn-rift sediments, possibly because of the weakening of extensional stresses away from the developing Tasman Sea.

  18. Does Sufficient Evidence Exist to Support a Causal Association between Vitamin D Status and Cardiovascular Disease Risk? An Assessment Using Hill’s Criteria for Causality

    Directory of Open Access Journals (Sweden)

    Patricia G. Weyland

    2014-09-01

    Full Text Available Serum 25-hydroxyvitamin D (25(OHD levels have been found to be inversely associated with both prevalent and incident cardiovascular disease (CVD risk factors; dyslipidemia, hypertension and diabetes mellitus. This review looks for evidence of a causal association between low 25(OHD levels and increased CVD risk. We evaluated journal articles in light of Hill’s criteria for causality in a biological system. The results of our assessment are as follows. Strength of association: many randomized controlled trials (RCTs, prospective and cross-sectional studies found statistically significant inverse associations between 25(OHD levels and CVD risk factors. Consistency of observed association: most studies found statistically significant inverse associations between 25(OHD levels and CVD risk factors in various populations, locations and circumstances. Temporality of association: many RCTs and prospective studies found statistically significant inverse associations between 25(OHD levels and CVD risk factors. Biological gradient (dose-response curve: most studies assessing 25(OHD levels and CVD risk found an inverse association exhibiting a linear biological gradient. Plausibility of biology: several plausible cellular-level causative mechanisms and biological pathways may lead from a low 25(OHD level to increased risk for CVD with mediators, such as dyslipidemia, hypertension and diabetes mellitus. Experimental evidence: some well-designed RCTs found increased CVD risk factors with decreasing 25(OHD levels. Analogy: the association between serum 25(OHD levels and CVD risk is analogous to that between 25(OHD levels and the risk of overall cancer, periodontal disease, multiple sclerosis and breast cancer. Conclusion: all relevant Hill criteria for a causal association in a biological system are satisfied to indicate a low 25(OHD level as a CVD risk factor.

  19. The assumed Aalenian stage-long eustatic lowstand did not exist: A review of the fresh evidence from Africa and other continents

    Science.gov (United States)

    Ruban, Dmitry A.; Sallam, Emad S.

    2018-03-01

    The views of the Jurassic eustatic fluctuations differ significantly: specialists either suggest multiple rises and falls ("Haq's view") or question the idea of global falls ("Hallam's view"). For instance, it is unclear whether there was a stage-long eustatic lowstand in the Aalenian. The presence of the noted alternatives is a serious problem complicating interpretation of events in the geological history. This paper summarizes the evidence of the Aalenian long-term shoreline shifts obtained in different regions of the world since 2000, i.e., after the noted views appeared. This evidence deals with the stratigraphical architecture of regions (interpreted in the present article), the established shoreline shifts (transgressions and regressions), and the knowledge of the regional tectonic activity. The compiled information characterizes "stable" regions located in the different parts of the world (Europe, Asia, Africa, North America, South America, and Australia). It is established that there were no regressions in some of these regions in the Aalenian, whereas regressions in the other regions can be explained by the influence of the tectonic activity. There was no coherence of the basin-scale eustatically-driven regressions (in contrast, the long-term Bajocian eustatic rise is proven by a coherence of regional transgressions). This finding contradicts the idea of the stage-long eustatic lowstand in the Aalenian and, thus, favours the "Hallam's view". This interpretation is in agreement with the present knowledge of the Earth's palaeoclimate and the past plate tectonics. This study demonstrates efficacy of interregional correlation of sea-level changes for resolution of the problem of the alternative views of the Jurassic eustasy.

  20. Identification and characterization of novel ERC-55 interacting proteins: evidence for the existence of several ERC-55 splicing variants; including the cytosolic ERC-55-C.

    Science.gov (United States)

    Ludvigsen, Maja; Jacobsen, Christian; Maunsbach, Arvid B; Honoré, Bent

    2009-12-01

    ERC-55, encoded from RCN2, is localized in the ER and belongs to the CREC protein family. ERC-55 is involved in various diseases and abnormal cell behavior, however, the function is not well defined and it has controversially been reported to interact with a cytosolic protein, the vitamin D receptor. We have used a number of proteomic techniques to further our functional understanding of ERC-55. By affinity purification, we observed interaction with a large variety of proteins, including those secreted and localized outside of the secretory pathway, in the cytosol and also in various organelles. We confirm the existence of several ERC-55 splicing variants including ERC-55-C localized in the cytosol in association with the cytoskeleton. Localization was verified by immunoelectron microscopy and sub-cellular fractionation. Interaction of lactoferrin, S100P, calcyclin (S100A6), peroxiredoxin-6, kininogen and lysozyme with ERC-55 was further studied in vitro by SPR experiments. Interaction of S100P requires [Ca(2+)] of approximately 10(-7) M or greater, while calcyclin interaction requires [Ca(2+)] of >10(-5) M. Interaction with peroxiredoxin-6 is independent of Ca(2+). Co-localization of lactoferrin, S100P and calcyclin with ERC-55 in the perinuclear area was analyzed by fluorescence confocal microscopy. The functional variety of the interacting proteins indicates a broad spectrum of ERC-55 activities such as immunity, redox homeostasis, cell cycle regulation and coagulation.

  1. Does a Certain Rule Exist in the Long-Term Change of a City’s Livability? Evidence from New York, Tokyo, and Shanghai

    Directory of Open Access Journals (Sweden)

    Jiabin Liu

    2017-09-01

    Full Text Available Livability is the ultimate goal of city development. However, the question of whether the changing pattern of a city’s livability follows a certain rule or not has seldom been argued. To address the question, three cities, including New York, Tokyo, and Shanghai are selected for case studies. Based on a proposed assessment framework, the long-term trend and determinants of three cities’ livability are quantified and investigated. The results suggest that the livability of three cities demonstrates a similar changing pattern during the last decades, with the level going through a three-staged N-curve development, increasing at the beginning, then declining in the mid-term, and rebounding afterward. It implies that the staged development rule should be followed when constructing a livable city. Efforts should be targeted towards the most underlying aspects in different periods. The empirical analysis of the three cities ascertains the existence of a development rule regarding livability, and suggests many potential uses for decision-making support.

  2. Mechanism of immune suppression by ultraviolet irradiation in vivo. I. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology

    International Nuclear Information System (INIS)

    De Fabo, E.C.; Noonan, F.P.

    1983-01-01

    UV irradiation of mice causes a systemic immune alteration that can be detected either by suppression of the immunologic rejection of UV-induced tumors, or by suppression of contact hypersensitivity (CHS). Suppression of these two immunologic responses has similar photobiologic characteristics and in both cases is associated with the generation of antigen-specific suppressor T cells. To identify whether a specific photoreceptor for this effect exists, the relative wavelength effectiveness (action spectrum) was determined for the UV-induced suppression of CHS. Narrow bands of UV (half bandwidth 3 nm) were used at 10 wavelengths from 250 to 320 nm to obtain dose-response curves. The action spectrum derived from the dose-response curves has a maximum between 260 and 270 nm, a shoulder at 280-290 nm, and declines steadily to approximately 3% of maximum at 320 nm. The finding of such a clearly defined wavelength dependence implies the presence of a specific photoreceptor for this effect. Removing the stratum corneum by tape stripping before UV irradiation prevented the suppression of CHS using 254-nm radiation, suggesting the photoreceptor is superficially located in the skin. The hypothesis is advanced that the photoreceptor for systemic UV-induced immunosuppression of contact hypersensitivity may be urocanic acid. As such, it may also play a role in UV-induced carcinogenesis via the production of tumor-specific suppressor cells

  3. Evidence for the Existence of One Antenna-Associated, Lipid-Dissolved and Two Protein-Bound Pools of Diadinoxanthin Cycle Pigments in Diatoms[C][W

    Science.gov (United States)

    Lepetit, Bernard; Volke, Daniela; Gilbert, Matthias; Wilhelm, Christian; Goss, Reimund

    2010-01-01

    We studied the localization of diadinoxanthin cycle pigments in the diatoms Cyclotella meneghiniana and Phaeodactylum tricornutum. Isolation of pigment protein complexes revealed that the majority of high-light-synthesized diadinoxanthin and diatoxanthin is associated with the fucoxanthin chlorophyll protein (FCP) complexes. The characterization of intact cells, thylakoid membranes, and pigment protein complexes by absorption and low-temperature fluorescence spectroscopy showed that the FCPs contain certain amounts of protein-bound diadinoxanthin cycle pigments, which are not significantly different in high-light and low-light cultures. The largest part of high-light-formed diadinoxanthin cycle pigments, however, is not bound to antenna apoproteins but located in a lipid shield around the FCPs, which is copurified with the complexes. This lipid shield is primarily composed of the thylakoid membrane lipid monogalactosyldiacylglycerol. We also show that the photosystem I (PSI) fraction contains a tightly connected FCP complex that is enriched in protein-bound diadinoxanthin cycle pigments. The peripheral FCP and the FCP associated with PSI are composed of different apoproteins. Tandem mass spectrometry analysis revealed that the peripheral FCP is composed mainly of the light-harvesting complex protein Lhcf and also significant amounts of Lhcr. The PSI fraction, on the other hand, shows an enrichment of Lhcr proteins, which are thus responsible for the diadinoxanthin cycle pigment binding. The existence of lipid-dissolved and protein-bound diadinoxanthin cycle pigments in the peripheral antenna and in PSI is discussed with respect to different specific functions of the xanthophylls. PMID:20935178

  4. Periprocedural Management of Non-Vitamin K Oral Anticoagulants in Chronic Kidney Disease: A Review of Existing Heterogeneity and Contemporary Evidence.

    Science.gov (United States)

    Gunasekaran, Prasad; Parashara, Deepak K

    2015-12-01

    Non vitamin-K oral anticoagulants (NOAC) have considerably enhanced anticoagulation practice for non-valvular atrial fibrillation with specific advantages of fixed dosing, non-fluctuant therapeutic levels and obviation of therapeutic level monitoring. NOAC pharmacology is remarkable for considerable renal excretion. Heterogeneity in the precise time cut-offs for discontinuation of NOACs prior to elective surgical or percutaneous procedures arise from the non-linear variations of drug excretion with different levels of creatinine clearances as in chronic kidney disease. Multiple authors have suggested cut-offs leading to ambiguity among practicing clinicians. Recent data pertaining to systemic thromboembolism, stroke and major bleeding derived from randomized controlled clinical trials have simplified the periprocedural management of NOACs. This review focusses on heterogeneity in the management of NOACs in patients with CKD in this peculiar scenario and highlights the contemporary evidence to support a unified approach towards perioperative management of NOACs. Multiple antidotes targeted towards binding of specific NOACs have been developed and are in the testing phase, thereby offering immense potential for rapid and complete reversal of NOAC activity in emergent procedures and major bleeding episodes. Targeted research on thromboembolism, stroke and major bleeding following temporary periprocedural interruption of NOACs using multicentric registries could further expand the clinical utility of these agents.

  5. Investigación cualitativa en odontología, análisis narrativo de la evidencia existente: narrative analysis of the existing evidence

    Directory of Open Access Journals (Sweden)

    Patricio Oliva

    Full Text Available Introducción: la investigación cualitativa es un tipo de aproximación a la realidad de forma comprensiva para fenómenos locales, bastante incipiente en el área de salud y aún más en odontología donde su utilización se restringe a investigaciones académicas particulares. Objetivo: evaluar la cantidad y contenidos de los resultados de las investigaciones odontológicas cualitativas publicadas en revistas entre los años 2008 hasta el año 2013. Metodología: se utiliza una búsqueda sistemática en buscadores como Pubmed, Scielo, Blackwell sinergy, Lilacs. Las palabras de búsqueda son dentistry, oral health, oral diseasse, qualitative, method qualitative, investigative qualitative. El análisis de datos es narrativo en el cual se sistematizan los resultados de los artículos seleccionados. Resultados: se encuentran 36 artículos cualitativos en los últimos cinco años, existe una limitada utilización de la investigación cualitativa en odontología, centrándose en la clínica e investigaciones observacionales descriptivas, lo que implica la existencia de un nicho investigativo no abordado y por ende no comprendido científicamente. Conclusiones: la evidencia cualitativa en odontología se agrupa en áreas definidas incorporando variables socioculturales con técnicas de recolección centrado en entrevistas y análisis comparativos tradicionales.

  6. Evidence for existence of spin glass state in single phase polycrystalline Gd0.99Sr0.01MnO3 through structural and magnetic properties

    International Nuclear Information System (INIS)

    Joy, Lija K.; Anantharaman, M.R.; Thomas, Senoy

    2013-01-01

    Single phase rare earth manganites have attracted scientific interest due to their interesting magnetic, electrical and structural properties. Bulk GdMnO 3 has metamagnetic features with a transition from antiferromagnetic to weak-ferromagnetic state upon cooling. Recently we have found promising magnetic behaviour when GdMnO 3 is doped with strontium. Magnetic behaviour of doped rare earth manganites in the form of Gd 1-x SrMnO 3 has attracted scientific interest due to their promising technological applications in data storage, as catalysts, as electrode materials and sensors. Irreversibility and sharp anomalies has been observed in the magnetization studies of polycrystalline Gd 0.99 Sr 0.01 MnO 3 perovskite synthesized by wet solid state reaction method. X-ray diffraction pattern of the system confirms the single phase orthorhombically distorted perovskite structure. The Field Cooled (FC) and Zero Field Cooled (ZFC) magnetization obtained as a function of temperature with external magnetic field 25Oe, 50Oe, and 200Oe showed thermal irreversibility along with a cusp below the ordering temperature indicating the appearance of spin glass state. The origin of this spin glass state is attributed to spin frustrations, due to the rare earth ions forming a deformed Kagome lattice. Under a magnetic field of 25Oe, the splitting between FC and ZFC magnetization is observed at 70K with a cusp in M ZFC at 45K and when the field is increased to 50Oe and 200Oe, the splitting becomes narrower and shows a shift in the irreversible temperature (T irr ) to lower temperatures 59K and 50K respectively. The spins are frozen in random directions due to a lack of long range magnetic interactions, when the system is cooled through its freezing temperature T f to T f . Room temperature variation of magnetization with applied field indicates the existence of ferromagnetic clusters of glass over antiferromagnetic background. Thermal irreversibility between FC and ZFC below T irr with a

  7. The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammals

    Directory of Open Access Journals (Sweden)

    Andrésdóttir Valgerdur

    2008-11-01

    Full Text Available Abstract Background APOBEC3 (A3 proteins deaminate DNA cytosines and block the replication of retroviruses and retrotransposons. Each A3 gene encodes a protein with one or two conserved zinc-coordinating motifs (Z1, Z2 or Z3. The presence of one A3 gene in mice (Z2–Z3 and seven in humans, A3A-H (Z1a, Z2a-Z1b, Z2b, Z2c-Z2d, Z2e-Z2f, Z2g-Z1c, Z3, suggests extraordinary evolutionary flexibility. To gain insights into the mechanism and timing of A3 gene expansion and into the functional modularity of these genes, we analyzed the genomic sequences, expressed cDNAs and activities of the full A3 repertoire of three artiodactyl lineages: sheep, cattle and pigs. Results Sheep and cattle have three A3 genes, A3Z1, A3Z2 and A3Z3, whereas pigs only have two, A3Z2 and A3Z3. A comparison between domestic and wild pigs indicated that A3Z1 was deleted in the pig lineage. In all three species, read-through transcription and alternative splicing also produced a catalytically active double domain A3Z2-Z3 protein that had a distinct cytoplasmic localization. Thus, the three A3 genes of sheep and cattle encode four conserved and active proteins. These data, together with phylogenetic analyses, indicated that a similar, functionally modular A3 repertoire existed in the common ancestor of artiodactyls and primates (i.e., the ancestor of placental mammals. This mammalian ancestor therefore possessed the minimal A3 gene set, Z1-Z2-Z3, required to evolve through a remarkable series of eight recombination events into the present day eleven Z domain human repertoire. Conclusion The dynamic recombination-filled history of the mammalian A3 genes is consistent with the modular nature of the locus and a model in which most of these events (especially the expansions were selected by ancient pathogenic retrovirus infections.

  8. The quest for stable circumbinary companions to post-common envelope sdB eclipsing binaries. Does the observational evidence support their existence?

    Science.gov (United States)

    Pulley, D.; Faillace, G.; Smith, D.; Watkins, A.; von Harrach, S.

    2018-03-01

    Context. Period variations have been detected in a number of eclipsing close compact binary subdwarf B stars (sdBs) and these have often been interpreted as being caused by circumbinary massive planets or brown dwarfs. According to canonical binary models, the majority of sdB systems are produced from low mass stars with degenerate cores where helium is ignited in flashes. Various evolutionary scenarios have been proposed for these stars, but a definite mechanism remains to be established. Equally puzzling is the formation of these putative circumbinary objects which must have formed from the remaining post-common envelope circumbinary disk or survived its evolution. Aim. In this paper we review the eclipse time variations (ETVs) exhibited by seven such systems (EC 10246-2707, HS 0705+6700, HS 2231+2441, J08205+0008, NSVS 07826147, NSVS 14256825, and NY Vir) and explore whether there is conclusive evidence that the ETVs observed over the last two decades can reliably predict the presence of one or more circumbinary bodies. Methods: We report 246 new observations of the seven sdB systems made between 2013 September and 2017 July using a worldwide network of telescopes. We combined our new data with previously published measurements to analyse the ETVs of these systems. Results: Our data show that period variations cannot be modelled simply on the basis of circumbinary objects. This implies that more complex processes may be taking place in these systems. These difficulties are compounded by the secondary star not being spectroscopically visible. From ETVs, it has historically been suggested that five of the seven binary systems reported here had circumbinary objects. Based on our recent observations and analysis, only three systems remain serious contenders. We find agreement with other observers that at least a decade of observations is required to establish reliable ephemerides. With longer observational baselines it is quite conceivable that the data will support

  9. Molecular evidence for the existence of lipopolysaccharide-induced TNF-alpha factor (LITAF) and Rel/NF-kB pathways in disk abalone (Haliotis discus discus).

    Science.gov (United States)

    De Zoysa, Mahanama; Nikapitiya, Chamilani; Oh, Chulhong; Whang, Ilson; Lee, Jae-Seong; Jung, Sung-Ju; Choi, Cheol Young; Lee, Jehee

    2010-01-01

    The lipopolysaccharide-induced TNF-alpha factor (LITAF) and Rel family nuclear factor kappaB (Rel/NF-kB) are two important transcription factors which play major roles in the regulating inflammatory cytokine, apoptosis and immune related genes. Here, we report the discovery of disk abalone LITAF (AbLITAF) and Rel/NF-kB (AbRel/NF-kB) homologues and their immune responses. Full-length cDNA of AbLITAF consists of 441 bp open reading frame (ORF) that translates into putative peptide of 147 aa. Analysis of AbLITAF sequence showed it has characteristic LITAF (Zn(+2)) binding domain with two CXXC motifs. Phylogenetic analysis results further revealed that AbLITAF is a member of LITAF family. AbRel/NF-kB is 584 aa protein that contains several characteristic motifs including Rel homology domain (RHD), Rel protein signature, DNA binding motif, nuclear localization signal (NLS) and transcription factor immunoglobulin - like fold (TIG) similar to their invertebrate and vertebrate counterparts. Tissue specific analysis results showed that both AbLITAF and AbRel/NF-kB mRNA was expressed ubiquitously in all selected tissues in constitutive manner. However, constitutive expression of AbLITAF was higher than AbRel/NF-kB in all tissues except mantle. Upon immune challenge by bacteria (Vibrio alginolyticus, Vibrio parahemolyticus and Lysteria monocytogenes) and viral hemoragic septicemia virus (VHSV), AbLITAF showed the significant up-regulation in gills while AbRel/NF-kB transcription was not change significantly. Based on transcriptional response against immune challenge, we could suggest that regulation of TNF-alpha expression may have occurred mainly by LITAF activation rather than NF-kB in disk abalone. The cumulative data from other molluscs and our data with reference to TNF-alpha, LITAF and Rel/NF-kB from disk abalone provide strong evidence that LITAF and NF-kB are independent pathways likely to occur throughout the Phylum mollusca. 2010 Elsevier Ltd. All rights reserved.

  10. Requirements for existing buildings

    DEFF Research Database (Denmark)

    Thomsen, Kirsten Engelund; Wittchen, Kim Bjarne

    This report collects energy performance requirements for existing buildings in European member states by June 2012.......This report collects energy performance requirements for existing buildings in European member states by June 2012....

  11. Greening Existing Tribal Buildings

    Science.gov (United States)

    Guidance about improving sustainability in existing tribal casinos and manufactured homes. Many steps can be taken to make existing buildings greener and healthier. They may also reduce utility and medical costs.

  12. Existence of undiscovered Uranian satellites

    International Nuclear Information System (INIS)

    Boice, D.C.

    1986-04-01

    Structure in the Uranian ring system as observed in recent occultations may contain indirect evidence for the existence of undiscovered satellites. Using the Alfven and Arrhenius (1975, 1976) scenario for the formation of planetary systems, the orbital radii of up to nine hypothetical satellites interior to Miranda are computed. These calculations should provide interesting comparisons when the results from the Voyager 2 encounter with Uranus are made public. 15 refs., 1 fig., 1 tab

  13. Gabapentin Superadded to a Pre-Existent Regime Containing Amytriptyline for Chronic Sciatica.

    Science.gov (United States)

    Robertson, Kelvin L; Marshman, Laurence A G

    2016-11-01

    There is currently a gross lack of evidence base guiding the medical management of chronic sciatica (CS). Only scant previous studies have assessed gabapentin (GBP) in CS. Extrapolating NICE-UK guidelines, prescribing authorities often insist on trialling anti-depressants (e.g., amytriptyline, AMP) as a first line for neuropathic pain states such as CS. When super-adding second-line agents, such as GBP, NICE-UK encourages overlap with first-line agents to avoid decreased pain-control. No study has reflected this practice. Evaluate efficacy and side effects (SE) of GBP superadded to a pre-existent regime containing AMP for CS. Prospective cohort of patients with unilateral CS attending a specialist spine clinic. Eligible patients had experienced partial benefit to a pre-existent regime containing AMP: none had significant SE. No drugs other than GBP were added or discontinued (the latter was considered inequitable) for 3 months. Visual analog pain score (VAS), Oswestry disability index (ODI), and SE were recorded. Efficacy: in 56% (43/77) there were reductions in VAS (5.3 ± 3.6→2.8 ± 2.7, P < 0.0001) and ODI (42.8 ± 31.1→30.7 ± 25.2, P = 0.008). SE: Eighty-two SE (23 types) were reported in 53% (41/77). Efficacy was less in those with SE: a trend existed for a lesser reduction in VAS (2.0 ± 2.4 v 3.0 ± 2.7, P = 0.08), which proved significant for ODI (8.1 ± 11.4 v 16.7 ± 18.2, P = 0.01). Thirty-four percent (26/77) discontinued GBP all within 1 week (i.e., during titration). This is the first prospective cohort study of GBP super-added to a pre-existent regime containing AMP for CS, as per routine clinical practice and NICE-UK principles. Super-added GBP demonstrated further efficacy over the previous regime in 56%; however, SE were frequent (53%) and diverse (23 types), and 34% abruptly discarded GBP. Although SE were associated with decreased efficacy, 37% nevertheless tolerated GBP despite SE. © 2016

  14. National energy policy provides scant power direction. [Canada

    Energy Technology Data Exchange (ETDEWEB)

    1976-05-07

    More federal direction on electric power developments was expected than actually materialized in the national energy policy released recently by Energy, Mines, and Resources. None of the primary objectives was specifically geared to improving the sagging power outlook. The five targets mentioned would have varying positive influences on Canadian power security if achieved, but oil and gas problems stole the spotlight. Failure of a national energy grid to make the top priority list was a disappointment. Observers had been expecting more prominent treatment for grid schemes in light of comments made by energy minister Alastair Gillespie at the recent energy conservation conference in Ottawa. But the strategy paper merely endorses the strengthening of regional interconnections, particularly in eastern Canada, and urges closer coordination among provincial utilities in planning and development. It reveals no new move to spur grid action and only reiterates the federal offer to back 50 percent of interconnection studies and capital costs. The paper does recognize that strengthened regional ties would lead to a form of integrated national system permitting more efficient systems growth, mutual assistance in the event of power failures, and some averaging out of peak and off-peak loads. They would economize on the need for stand-by power and enhance more rational expansion.

  15. Why preeclampsia still exists?

    Science.gov (United States)

    Chelbi, Sonia T; Veitia, Reiner A; Vaiman, Daniel

    2013-08-01

    Preeclampsia (PE) is a deadly gestational disease affecting up to 10% of women and specific of the human species. Preeclampsia is clearly multifactorial, but the existence of a genetic basis for this disease is now clearly established by the existence of familial cases, epidemiological studies and known predisposing gene polymorphisms. PE is very common despite the fact that Darwinian pressure should have rapidly eliminated or strongly minimized the frequency of predisposing alleles. Consecutive pregnancies with the same partner decrease the risk and severity of PE. Here, we show that, due to this peculiar feature, preeclampsia predisposing-alleles can be differentially maintained according to the familial structure. Thus, we suggest that an optimal frequency of PE-predisposing alleles in human populations can be achieved as a result of a trade-off between benefits of exogamy, importance for maintaining genetic diversity and increase of the fitness owing to a stable paternal investment. Copyright © 2013 Elsevier Ltd. All rights reserved.

  16. Existence of Projective Planes

    OpenAIRE

    Perrott, Xander

    2016-01-01

    This report gives an overview of the history of finite projective planes and their properties before going on to outline the proof that no projective plane of order 10 exists. The report also investigates the search carried out by MacWilliams, Sloane and Thompson in 1970 [12] and confirms their result by providing independent verification that there is no vector of weight 15 in the code generated by the projective plane of order 10.

  17. Does bioethics exist?

    Science.gov (United States)

    Turner, L

    2009-12-01

    Bioethicists disagree over methods, theories, decision-making guides, case analyses and public policies. Thirty years ago, the thinking of many scholars coalesced around a principlist approach to bioethics. That mid-level mode of moral reasoning is now one of many approaches to moral deliberation. Significant variation in contemporary approaches to the study of ethical issues related to medicine, biotechnology and health care raises the question of whether bioethics exists as widely shared method, theory, normative framework or mode of moral reasoning.

  18. Evidence that proliferation of golgi apparatus depends on both de novo generation from the endoplasmic reticulum and formation from pre-existing stacks during the growth of tobacco BY-2 cells.

    Science.gov (United States)

    Abiodun, Moses Olabiyi; Matsuoka, Ken

    2013-04-01

    In higher plants, the numbers of cytoplasmic-distributed Golgi stacks differ based on function, age and cell type. It has not been clarified how the numbers are controlled, whether all the Golgi apparatus in a cell function equally and whether the increase in Golgi number is a result of the de novo formation from the endoplasmic reticulum (ER) or fission of pre-existing stacks. A tobacco prolyl 4-hydroxylase (NtP4H1.1), which is a cis-Golgi-localizing type II membrane protein, was tagged with a photoconvertible fluorescent protein, mKikGR (monomeric Kikume green red), and expressed in tobacco bright yellow 2 (BY-2) cells. Transformed cells were exposed to purple light to convert the fluorescence from green to red. A time-course analysis after the conversion revealed a progressive increase in green puncta and a decrease in the red puncta. From 3 to 6 h, we observed red, yellow and green fluorescent puncta corresponding to pre-existing Golgi; Golgi containing both pre-existing and newly synthesized protein; and newly synthesized Golgi. Analysis of the number and fluorescence of Golgi at different phases of the cell cycle suggested that an increase in Golgi number with both division and de novo synthesis occurred concomitantly with DNA replication. Investigation with different inhibitors suggested that the formation of new Golgi and the generation of Golgi containing both pre-existing and newly synthesized protein are mediated by different machineries. These results and modeling based on quantified results indicate that the Golgi apparatuses in tobacco BY-2 cells are not uniform and suggest that both de novo synthesis from the ER and Golgi division contribute almost equally to the increase in proliferating cells.

  19. O Ponto G Existe?

    Directory of Open Access Journals (Sweden)

    Carlos Alexandre Molina Noccioli

    2016-07-01

    Full Text Available Este trabalho busca analisar o tratamento linguístico-discursivo das informações acerca de um tópicotemático tradicionalmente visto como tabu, relacionado a questões sexuais, na notícia O ponto G existe?, publicada em 2008, na revista brasileira Superinteressante, destacando-se como o conhecimento em questão é representado socialmente ao se considerar a linha editorial da revista. A notícia caracteriza-se como um campo fértil para a análise das estratégias divulgativas, já que atrai, inclusive pelas escolhas temáticas, a curiosidade dos leitores. Imbuído de um tema excêntrico, o texto consegue angariar um público jovem interessado em discussões polêmicas relacionadas ao seu universo.

  20. Lebesgue Sets Immeasurable Existence

    Directory of Open Access Journals (Sweden)

    Diana Marginean Petrovai

    2012-12-01

    Full Text Available It is well known that the notion of measure and integral were released early enough in close connection with practical problems of measuring of geometric figures. Notion of measure was outlined in the early 20th century through H. Lebesgue’s research, founder of the modern theory of measure and integral. It was developed concurrently a technique of integration of functions. Gradually it was formed a specific area todaycalled the measure and integral theory. Essential contributions to building this theory was made by a large number of mathematicians: C. Carathodory, J. Radon, O. Nikodym, S. Bochner, J. Pettis, P. Halmos and many others. In the following we present several abstract sets, classes of sets. There exists the sets which are not Lebesgue measurable and the sets which are Lebesgue measurable but are not Borel measurable. Hence B ⊂ L ⊂ P(X.

  1. EXIST Perspective for SFXTs

    Science.gov (United States)

    Ubertini, Pietro; Sidoli, L.; Sguera, V.; Bazzano, A.

    2009-12-01

    Supergiant Fast X-ray Transients (SFXTs) are one of the most interesting (and unexpected) results of the INTEGRAL mission. They are a new class of HMXBs displaying short hard X-ray outbursts (duration less tha a day) characterized by fast flares (few hours timescale) and large dinamic range (10E3-10E4). The physical mechanism driving their peculiar behaviour is still unclear and highly debated: some models involve the structure of the supergiant companion donor wind (likely clumpy, in a spherical or non spherical geometry) and the orbital properties (wide separation with eccentric or circular orbit), while others involve the properties of the neutron star compact object and invoke very low magnetic field values (B 1E14 G, magnetars). The picture is still highly unclear from the observational point of view as well: no cyclotron lines have been detected in the spectra, thus the strength of the neutron star magnetic field is unknown. Orbital periods have been measured in only 4 systems, spanning from 3.3 days to 165 days. Even the duty cycle seems to be quite different from source to source. The Energetic X-ray Imaging Survey Telescope (EXIST), with its hard X-ray all-sky survey and large improved limiting sensitivity, will allow us to get a clearer picture of SFXTs. A complete census of their number is essential to enlarge the sample. A long term and continuous as possible X-ray monitoring is crucial to -(1) obtain the duty cycle, -(2 )investigate their unknown orbital properties (separation, orbital period, eccentricity),- (3) to completely cover the whole outburst activity, (4)-to search for cyclotron lines in the high energy spectra. EXIST observations will provide crucial informations to test the different models and shed light on the peculiar behaviour of SFXTs.

  2. Nuclear resonant scattering evidence of the phase co-existence during structural phase transformation in [Fe(H{sub 2}O){sub 6}](ClO{sub 4}){sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Vanko, Gy. [European Synchrotron Radiation Facility, BP 220, F-38043 Grenoble (France); Research Group for Nuclear Techniques in Structural Chemistry, Hungarian Academy of Sciences at Eoetvoes L. University, P.O. Box 32, H-1518 Budapest (Hungary); Bottyan, L. [KFKI Research Institute for Particle and Nuclear Physics, P.O. Box 49, H-1525 Budapest (Hungary); Deak, L. [KFKI Research Institute for Particle and Nuclear Physics, P.O. Box 49, H-1525 Budapest (Hungary); Fetzer, Cs. [KFKI Research Institute for Particle and Nuclear Physics, P.O. Box 49, H-1525 Budapest (Hungary); Juhasz, G. [Department of Nuclear Chemistry, Eoetvoes L. University, P.O. Box 32, H-1518 Budapest (Hungary); Leupold, O. [European Synchrotron Radiation Facility, BP 220, F-38043 Grenoble (France); Institut fuer Experimentalphysik, Universitaet Hamburg, Luruper Chaussee 149, D-22761 Hamburg (Germany); Molnar, B. [KFKI Research Institute for Particle and Nuclear Physics, P.O. Box 49, H-1525 Budapest (Hungary); Rueter, H.D. [KFKI Research Institute for Particle and Nuclear Physics, P.O. Box 49, H-1525 Budapest (Hungary); Szilagyi, E. [KFKI Research Institute for Particle and Nuclear Physics, P.O. Box 49, H-1525 Budapest (Hungary); Nagy, D.L. [KFKI Research Institute for Particle and Nuclear Physics, P.O. Box 49, H-1525 Budapest (Hungary)]. E-mail: nagy@rmki.kfki.hu

    2005-09-29

    The phase transition associated with orbital-ground-state inversion of high-spin Fe{sup 2+} in [Fe(H{sub 2}O){sub 6}](ClO{sub 4}){sub 2} was studied with nuclear resonant forward scattering of synchrotron radiation (SR). The sudden change in the {sup 57}Fe{sup 2+} quadrupole interaction results in a change of the quantum-beat frequencies. Quantum-beat patterns taken at the phase transition of [Fe(H{sub 2}O){sub 6}](ClO{sub 4}){sub 2} are in accordance with mainly coherent rather than with incoherent sums of the scattering amplitudes of the high- and low-quadrupole-interaction phases, a fact supporting the real co-existence of the two phases.

  3. Habituation in non-neural organisms: evidence from slime moulds

    OpenAIRE

    Boisseau, Romain P.; Vogel, David; Dussutour, Audrey

    2016-01-01

    Learning, defined as a change in behaviour evoked by experience, has hitherto been investigated almost exclusively in multicellular neural organisms. Evidence for learning in non-neural multicellular organisms is scant, and only a few unequivocal reports of learning have been described in single-celled organisms. Here we demonstrate habituation, an unmistakable form of learning, in the non-neural organism Physarum polycephalum. In our experiment, using chemotaxis as the behavioural output and...

  4. The Myth of Discovering Absolute Truth through Science:How Szasz Mistook Scientific Evidence for Absolute Truth in An Attempt to Deny the Existence of Mental Illness, and Invalidated Experiences of Those Affected by Mental Disorders

    Directory of Open Access Journals (Sweden)

    Mirsad Serdarevic

    2010-08-01

    Full Text Available The purpose of this article is to illustrate limitations of Dr. Thomas S. Szasz's absolutist approach in critiquing psychiatry, psychotherapy, and the concept of mental illness most famously expressed in The Myth of Mental Illness (Szasz, 1961. This article illustrates that Szasz mistook scientific proof for absolute truth. First, a comparison of scientific proof to its superior relation, mathematical proof, illustrates its theoretical short-comings. Szasz relies, sometimes subtly, sometimes quite overtly, but always selectively on "real science" to present psychiatry and the mental health fields as imposters in the field of medicine or health, while neglecting to see or discuss limitations of "science" in general and medicine in particular. Secondly, a summary of evidence supporting psychotherapy's effectiveness will be presented, the discussion of which was either consciously or unconsciously omitted in Szasz's (1978; 1988 The Myth of Psychotherapy. Third, summary of Pennington's (2002 integration of both biological and psychological basis of psychopathology through cognitive neuroscientific theoretical framework is presented as it reasonably addresses Szasz's confusion about and critique of mental illness and the mind-body problem.

  5. 75 FR 45013 - Pre-Existing Condition Insurance Plan Program

    Science.gov (United States)

    2010-07-30

    ... Department of Homeland Security's U.S. Citizenship and Immigration Services (USCIS) Systematic Alien... pre-existing condition based on evidence of the existence or history of certain medical or health...

  6. How to prove the existence of metabolons?

    DEFF Research Database (Denmark)

    Bassard, Jean-Étienne André; Halkier, Barbara Ann

    2017-01-01

    Sequential enzymes in biosynthetic pathways are organized in metabolons. It is challenging to provide experimental evidence for the existence of metabolons as biosynthetic pathways are composed of highly dynamic protein–protein interactions. Many different methods are being applied, each with str...

  7. Rosmini's metaphysical evidence for the existence of God | Swartz ...

    African Journals Online (AJOL)

    Rosmini is of the opinion that the soul consists of both a bodily (natural) and a godly component. Both components unite in humankind. In Rosmini's cosmology, humankind is viewed in relation to God and the world (cosmos). Cosmology cannot be comprehensively explained without linking ontology and theology, ...

  8. Ontological Proofs of Existence and Non-Existence

    Czech Academy of Sciences Publication Activity Database

    Hájek, Petr

    2008-01-01

    Roč. 90, č. 2 (2008), s. 257-262 ISSN 0039-3215 R&D Projects: GA AV ČR IAA100300503 Institutional research plan: CEZ:AV0Z10300504 Keywords : ontological proofs * existence * non-existence * Gödel * Caramuel Subject RIV: BA - General Mathematics

  9. Existence theory in optimal control

    International Nuclear Information System (INIS)

    Olech, C.

    1976-01-01

    This paper treats the existence problem in two main cases. One case is that of linear systems when existence is based on closedness or compactness of the reachable set and the other, non-linear case refers to a situation where for the existence of optimal solutions closedness of the set of admissible solutions is needed. Some results from convex analysis are included in the paper. (author)

  10. International Taxation and FDI Strategies: Evidence From US Cross-Border Acquisitions

    OpenAIRE

    Nils Herger; Christos Kotsogiannis; Steve McCorriston

    2011-01-01

    While there is a well-established body of empirical research documenting the negative effect of taxation on foreign direct investment (FDI), there is scant evidence on the extent to which international tax considerations (double taxation, international tax relief stipulated in bilateral tax treaties and the effect of withholding taxes) affect the role of taxation for FDI, and how tax issues differ according to the investment strategies—‘horizontal’ and ‘vertical’—pursued by %multinational fir...

  11. Existing Steel Railway Bridges Evaluation

    Science.gov (United States)

    Vičan, Josef; Gocál, Jozef; Odrobiňák, Jaroslav; Koteš, Peter

    2016-12-01

    The article describes general principles and basis of evaluation of existing railway bridges based on the concept of load-carrying capacity determination. Compared to the design of a new bridge, the modified reliability level for existing bridges evaluation should be considered due to implementation of the additional data related to bridge condition and behaviour obtained from regular inspections. Based on those data respecting the bridge remaining lifetime, a modification of partial safety factors for actions and materials could be respected in the bridge evaluation process. A great attention is also paid to the specific problems of determination of load-caring capacity of steel railway bridges in service. Recommendation for global analysis and methodology for existing steel bridge superstructure load-carrying capacity determination are described too.

  12. Existing Steel Railway Bridges Evaluation

    Directory of Open Access Journals (Sweden)

    Vičan Josef

    2016-12-01

    Full Text Available The article describes general principles and basis of evaluation of existing railway bridges based on the concept of load-carrying capacity determination. Compared to the design of a new bridge, the modified reliability level for existing bridges evaluation should be considered due to implementation of the additional data related to bridge condition and behaviour obtained from regular inspections. Based on those data respecting the bridge remaining lifetime, a modification of partial safety factors for actions and materials could be respected in the bridge evaluation process. A great attention is also paid to the specific problems of determination of load-caring capacity of steel railway bridges in service. Recommendation for global analysis and methodology for existing steel bridge superstructure load-carrying capacity determination are described too.

  13. Limitations of existing web services

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Limitations of existing web services. Uploading or downloading large data. Serving too many user from single source. Difficult to provide computer intensive job. Depend on internet and its bandwidth. Security of data in transition. Maintain confidentiality of data ...

  14. Performance of Existing Hydrogen Stations

    Energy Technology Data Exchange (ETDEWEB)

    Sprik, Samuel [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Kurtz, Jennifer M [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Ainscough, Christopher D [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Saur, Genevieve [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Peters, Michael C [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-12-01

    In this presentation, the National Renewable Energy Laboratory presented aggregated analysis results on the performance of existing hydrogen stations, including performance, operation, utilization, maintenance, safety, hydrogen quality, and cost. The U.S. Department of Energy funds technology validation work at NREL through its National Fuel Cell Technology Evaluation Center (NFCTEC).

  15. Does a cosmic censor exist

    International Nuclear Information System (INIS)

    Israel, W.

    1984-01-01

    A distinction is drawn between the event horizon conjecture (EHC), the conjecture that an event horizon forms in a gravitational collapse, and cosmic censorship, the idea that every singularity which develops in the course of collapse must be enclosed within a horizon. It is argued that a body of circumstantial evidence seems to favor EHC, but cosmic censorship seems contraindicated

  16. The EXIST Mission Concept Study

    Science.gov (United States)

    Fishman, Gerald J.; Grindlay, J.; Hong, J.

    2008-01-01

    EXIST is a mission designed to find and study black holes (BHs) over a wide range of environments and masses, including: 1) BHs accreting from binary companions or dense molecular clouds throughout our Galaxy and the Local Group, 2) supermassive black holes (SMBHs) lying dormant in galaxies that reveal their existence by disrupting passing stars, and 3) SMBHs that are hidden from our view at lower energies due to obscuration by the gas that they accrete. 4) the birth of stellar mass BHs which is accompanied by long cosmic gamma-ray bursts (GRBs) which are seen several times a day and may be associated with the earliest stars to form in the Universe. EXIST will provide an order of magnitude increase in sensitivity and angular resolution as well as greater spectral resolution and bandwidth compared with earlier hard X-ray survey telescopes. With an onboard optical-infra red (IR) telescope, EXIST will measure the spectra and redshifts of GRBs and their utility as cosmological probes of the highest z universe and epoch of reionization. The mission would retain its primary goal of being the Black Hole Finder Probe in the Beyond Einstein Program. However, the new design for EXIST proposed to be studied here represents a significant advance from its previous incarnation as presented to BEPAC. The mission is now less than half the total mass, would be launched on the smallest EELV available (Atlas V-401) for a Medium Class mission, and most importantly includes a two-telescope complement that is ideally suited for the study of both obscured and very distant BHs. EXIST retains its very wide field hard X-ray imaging High Energy Telescope (HET) as the primary instrument, now with improved angular and spectral resolution, and in a more compact payload that allows occasional rapid slews for immediate optical/IR imaging and spectra of GRBs and AGN as well as enhanced hard X-ray spectra and timing with pointed observations. The mission would conduct a 2 year full sky survey in

  17. The Greenhouse Effect Does Exist!

    OpenAIRE

    Ebel, Jochen

    2009-01-01

    In particular, without the greenhouse effect, essential features of the atmospheric temperature profile as a function of height cannot be described, i.e., the existence of the tropopause above which we see an almost isothermal temperature curve, whereas beneath it the temperature curve is nearly adiabatic. The relationship between the greenhouse effect and observed temperature curve is explained and the paper by Gerlich and Tscheuschner [arXiv:0707.1161] critically analyzed. Gerlich and Tsche...

  18. Europe - space for transcultural existence?

    OpenAIRE

    Tamcke, Martin; Janny, de Jong; Klein, Lars; Waal, Margriet

    2013-01-01

    Europe - Space for Transcultural Existence? is the first volume of the new series, Studies in Euroculture, published by Göttingen University Press. The series derives its name from the Erasmus Mundus Master of Excellence Euroculture: Europe in the Wider World, a two year programme offered by a consortium of eight European universities in collaboration with four partner universities outside Europe. This master highlights regional, national and supranational dimensions of the European democrati...

  19. UNCITRAL: Changes to existing law

    OpenAIRE

    Andersson, Joakim

    2008-01-01

    The UNCITRAL Convention on Contracts for the International Carriage of Goods [wholly or partly] by Sea has an ambition of replacing current maritime regimes and expands the application of the Convention to include also multimodal transport. This thesis questions what changes to existing law, in certain areas, the new Convention will bring compared to the current regimes. In the initial part, the thesis provides for a brief background and history of international maritime regulations and focus...

  20. Existence Results for Incompressible Magnetoelasticity

    Czech Academy of Sciences Publication Activity Database

    Kružík, Martin; Stefanelli, U.; Zeman, J.

    2015-01-01

    Roč. 35, č. 6 (2015), s. 2615-2623 ISSN 1078-0947 R&D Projects: GA ČR GA13-18652S Institutional support: RVO:67985556 Keywords : magnetoelasticity * magnetostrictive solids * incompressibility * existence of minimizers * quasistatic evolution * energetic solution Subject RIV: BA - General Mathematics Impact factor: 1.127, year: 2015 http://library.utia.cas.cz/separaty/2015/MTR/kruzik-0443017.pdf

  1. Does exercise pulmonary hypertension exist?

    Science.gov (United States)

    Lau, Edmund M; Chemla, Denis; Whyte, Kenneth; Kovacs, Gabor; Olschewski, Horst; Herve, Philippe

    2016-09-01

    The exercise definition of pulmonary hypertension using a mean pulmonary artery pressure threshold of greater than 30 mmHg was abandoned following the 4th World Pulmonary Hypertension Symposium in 2008, as this definition was not supported by evidence and healthy individuals frequently exceed this threshold. Meanwhile, the clinical value of exercise pulmonary hemodynamic testing has also been questioned. Recent data support the notion that an abnormal pulmonary hemodynamic response during exercise (or exercise pulmonary hypertension) is associated with symptoms and exercise limitation. Pathophysiologic mechanisms accounting for the development of exercise pulmonary hypertension include increased vascular resistance, excessive elevation in left atrial pressure and/or increased volume of trapped air during exercise, resulting in a steep rise in pulmonary artery pressure relative to cardiac output. Recent evidence suggests that exercise pulmonary hypertension may be defined by a mean pulmonary artery pressure surpassing 30 mmHg together with a simultaneous total pulmonary resistance exceeding 3 WU. Exercise pulmonary hypertension is a clinically relevant entity and an improved definition has been suggested based on new evidence. Exercise pulmonary hemodynamics may help unmask early or latent disease, particularly in populations that are at high risk for the development of pulmonary hypertension.

  2. Quantum logics with existence property

    International Nuclear Information System (INIS)

    Schindler, C.

    1991-01-01

    A quantum logic (σ-orthocomplete orthomodular poset L with a convex, unital, and separating set Δ of states) is said to have the existence property if the expectation functionals on lin(Δ) associated with the bounded observables of L form a vector space. Classical quantum logics as well as the Hilbert space logics of traditional quantum mechanics have this property. The author shows that, if a quantum logic satisfies certain conditions in addition to having property E, then the number of its blocks (maximal classical subsystems) must either be one (classical logics) or uncountable (as in Hilbert space logics)

  3. PASSCLAIM - Synthesis and review of existing processes.

    Science.gov (United States)

    Richardson, David P; Affertsholt, Tage; Asp, Nils-Georg; Bruce, Ake; Grossklaus, Rolf; Howlett, John; Pannemans, Daphne; Ross, Richard; Verhagen, Hans; Viechtbauer, Volker

    2003-03-01

    Several approaches to the use of health claims on foods have been made around the world, and the common theme is that any health claim will require scientific validation and substantiation. There is also broad consensus that any regulatory framework should protect the consumer, promote fair trade and encourage innovation in the food industry.This paper is based on a critical evaluation of existing international approaches to the scientific substantiation of health claims, with a view to identifying common new ideas, definitions, best practice and a methodology to underpin current and future developments. There is a clear need to have uniform understanding, terminology and description of types of nutrition and health claims. Two broad categories were defined: Nutrition Claims, i. e. what the product contains, and Health Claims, i. e. relating to health, well-being and/or performance, including well-established nutrient function claims, enhanced function claims and disease risk reduction claims. Such health claims relate to what the food or food components does or do. The categories of health claims are closely and progressively related and are, in practice, part of a continuum. Provision is also made for "generic" or well-established, generally accepted claims and for "innovative" or "product-specific" claims. Special attention was paid to reflect the health-promoting properties of a food or food component in such a way as to facilitate the making of risk reduction claims outside the medical scope of the term prevention. The paper sets out basic principles and guidelines for communication of health claims and principles of nutritional safety. The main body of the work examines the process for the assessment of scientific support for health claims on food and emphasises an evidence-based approach consisting of: Identification of all relevant studies exploring the collection of evidence, data searches, the nature of the scientific evidence, sources of scientific data

  4. Does cold nuclear fusion exist?

    International Nuclear Information System (INIS)

    Brudanin, V.B.; Bystritskij, V.M.; Egorov, V.G.; Shamsutdinov, S.G.; Shyshkin, A.L.; Stolupin, V.A.; Yutlandov, I.A.

    1989-01-01

    The results of investigation of cold nuclear fusion on palladium are given both for electrolysis of heavy water D 2 O and mixture D 2 O + H 2 O) (1:1) and for palladium saturation with gaseous deuterium. The possibility of existance of this phenomenon was examined by detection of neutrons and gamma quanta from reactions: d + d → 3 He + n + 3.27 MeV, p + d → 3 He + γ + 5.5 MeV. Besides these reactions were identified by measuring the characteristic X radiation of palladium due to effect of charged products 3 He, p, t. The upper limits of the intensities of hypothetical sources of neutrons and gamma quanta at the 95% confidence level were obtained to be Q n ≤ 2x10 -2 n/sxcm 3 Pd, Q γ ≤ 2x10 -3 γ/sxcm 3 Pd. 2 refs.; 4 figs.; 2 tabs

  5. Straightening: existence, uniqueness and stability

    Science.gov (United States)

    Destrade, M.; Ogden, R. W.; Sgura, I.; Vergori, L.

    2014-01-01

    One of the least studied universal deformations of incompressible nonlinear elasticity, namely the straightening of a sector of a circular cylinder into a rectangular block, is revisited here and, in particular, issues of existence and stability are addressed. Particular attention is paid to the system of forces required to sustain the large static deformation, including by the application of end couples. The influence of geometric parameters and constitutive models on the appearance of wrinkles on the compressed face of the block is also studied. Different numerical methods for solving the incremental stability problem are compared and it is found that the impedance matrix method, based on the resolution of a matrix Riccati differential equation, is the more precise. PMID:24711723

  6. Why do interstellar grains exist

    International Nuclear Information System (INIS)

    Seab, C.G.; Hollenbach, D.J.; Mckee, C.F.; Tielens, A.G.G.M.

    1986-01-01

    There exists a discrepancy between calculated destruction rates of grains in the interstellar medium and postulated sources of new grains. This problem was examined by modelling the global life cycle of grains in the galaxy. The model includes: grain destruction due to supernovae shock waves; grain injection from cool stars, planetary nebulae, star formation, novae, and supernovae; grain growth by accretion in dark clouds; and a mixing scheme between phases of the interstellar medium. Grain growth in molecular clouds is considered as a mechanism or increasing the formation rate. To decrease the shock destruction rate, several new physical processes, such as partial vaporization effects in grain-grain collisions, breakdown of the small Larmor radius approximation for betatron acceleration, and relaxation of the steady-state shock assumption are included

  7. Existe sujeito em Michel Maffesoli?

    Directory of Open Access Journals (Sweden)

    Marli Appel da Silva

    2010-06-01

    Full Text Available Este ensaio discute a concepção de sujeito na abordagem teórica de Michel Maffesoli. As ideias desse autor estão em voga em alguns meios acadêmicos no Brasil e são difundidas por algumas mídias de grande circulação nacional. Entretanto, ao longo de suas obras, os pressupostos que definem quem é o sujeito maffesoliano se encontram pouco clarificados. Portanto, para alcançar o objetivo a que se propõe, este ensaio desenvolve uma análise da epistemologia e da ontologia maffesoliana com a finalidade de compreender as origens dos pressupostos desse autor, ou seja, as teorias e os autores em que Maffesoli se baseou para desenvolver uma visão de sujeito. Com essa compreensão, pretende-se responder à questão: existe sujeito na abordagem teórica de Maffesoli.

  8. Evidence and evidence gaps in tinnitus therapy

    Science.gov (United States)

    Hesse, Gerhard

    2016-01-01

    A nearly endless number of procedures has been tried and in particular sold for the treatment of tinnitus, unfortunately they have not been evaluated appropriately in an evidence-based way. A causal therapy, omitting the tinnitus still does not exist, actually it cannot exist because of the various mechanisms of its origin. However or perhaps because of that, medical interventions appear and reappear like fashion trends that can never be proven by stable and reliable treatment success. This contribution will discuss and acknowledge all current therapeutic procedures and the existing or non-existing evidence will be assessed. Beside external evidence, the term of evidence also encompasses the internal evidence, i.e. the experience of the treating physician and the patient’s needs shall be included. While there is no evidence for nearly all direct procedures that intend modulating or stimulating either the cochlea or specific cervical regions such as the auditory cortex, there are therapeutic procedures that are acknowledged in clinical practice and have achieved at least a certain degree of evidence and generate measurable effect sizes. Those are in particular habituation therapy and psychotherapeutic measures, especially if they are combined with concrete measures for improved audio perception (hearing aids, CI, hearing therapies). PMID:28025604

  9. Summary of existing uncertainty methods

    International Nuclear Information System (INIS)

    Glaeser, Horst

    2013-01-01

    A summary of existing and most used uncertainty methods is presented, and the main features are compared. One of these methods is the order statistics method based on Wilks' formula. It is applied in safety research as well as in licensing. This method has been first proposed by GRS for use in deterministic safety analysis, and is now used by many organisations world-wide. Its advantage is that the number of potential uncertain input and output parameters is not limited to a small number. Such a limitation was necessary for the first demonstration of the Code Scaling Applicability Uncertainty Method (CSAU) by the United States Regulatory Commission (USNRC). They did not apply Wilks' formula in their statistical method propagating input uncertainties to obtain the uncertainty of a single output variable, like peak cladding temperature. A Phenomena Identification and Ranking Table (PIRT) was set up in order to limit the number of uncertain input parameters, and consequently, the number of calculations to be performed. Another purpose of such a PIRT process is to identify the most important physical phenomena which a computer code should be suitable to calculate. The validation of the code should be focused on the identified phenomena. Response surfaces are used in some applications replacing the computer code for performing a high number of calculations. The second well known uncertainty method is the Uncertainty Methodology Based on Accuracy Extrapolation (UMAE) and the follow-up method 'Code with the Capability of Internal Assessment of Uncertainty (CIAU)' developed by the University Pisa. Unlike the statistical approaches, the CIAU does compare experimental data with calculation results. It does not consider uncertain input parameters. Therefore, the CIAU is highly dependent on the experimental database. The accuracy gained from the comparison between experimental data and calculated results are extrapolated to obtain the uncertainty of the system code predictions

  10. Seismic evaluation of existing nuclear power plants

    International Nuclear Information System (INIS)

    2003-01-01

    The IAEA nuclear safety standards publications address the site evaluation and the design of new nuclear power plants (NPPs), including seismic hazard assessment and safe seismic design, at the level of the Safety Requirements as well as at the level of dedicated Safety Guides. It rapidly became apparent that the existing nuclear safety standards documents were not adequate for handling specific issues in the seismic evaluation of existing NPPs, and that a dedicated document was necessary. This is the purpose of this Safety Report, which is written in the spirit of the nuclear safety standards and can be regarded as guidance for the interpretation of their intent. Worldwide experience shows that an assessment of the seismic capacity of an existing operating facility can be prompted for the following: (a) Evidence of a greater seismic hazard at the site than expected before, owing to new or additional data and/or to new methods; (b) Regulatory requirements, such as periodic safety reviews, to ensure that the plant has adequate margins for seismic loads; (c) Lack of anti-seismic design or poor anti-seismic design; (d) New technical finding such as vulnerability of some structures (masonry walls) or equipment (relays), other feedback and new experience from real earthquakes. Post-construction evaluation programmes evaluate the current capability of the plant to withstand the seismic concern and identify any necessary upgrades or changes in operating procedures. Seismic qualification is distinguished from seismic evaluation primarily in that seismic qualification is intended to be performed at the design stage of a plant, whereas seismic evaluation is intended to be applied after a plant has been constructed. Although some guidelines do exist for the evaluation of existing NPPs, these are not established at the level of a regulatory guide or its equivalent. Nevertheless, a number of existing NPPs throughout the world have been and are being subjected to review of their

  11. The Evidence Movement

    DEFF Research Database (Denmark)

    Hansen, Hanne Foss; Rieper, Olaf

    2009-01-01

    The evidence movement and the idea of systematic reviews, defined as summaries of the results of already existing evaluation and research projects, have gained considerable support in recent years as many international as well as national evidence-producing organizations have been established...

  12. Work-life integration in neuropsychology: a review of the existing literature and preliminary recommendations.

    Science.gov (United States)

    Feigon, Maia; Block, Cady; Guidotti Breting, Leslie; Boxley, Laura; Dawson, Erica; Cobia, Derin

    2018-02-01

    The purpose of the current review paper is to identify and describe challenges to work-life integration in neuropsychology, and from this review extrapolate an initial set of recommendations and present a set of scenarios in which the recommendations might apply in the hopes of improving quality of life for current and prospective neuropsychologists. Specific areas of focus include diversity, early and mid-career transitions, and potential barriers to advancement in specific practice settings. A broad review was conducted of extant literature on work-life integration. There is scant scientific literature in this area that is specific to neuropsychologists, or even psychology as a whole. Subsequently, the majority of this review was collected from more developed literatures in business and medical fields. The authors then provided recommendations based on experiences in their respective careers. Attempts were made to promote generalizability of recommendations for neuropsychologists in different settings. Evidence supports a potentially adverse impact on quality of life and overall life satisfaction when work and personal lives conflict. This manuscript identifies some of the potential risks when work and life responsibilities are not well integrated. It is anticipated this will serve as a catalyst for future studies on work-life integration in the field of neuropsychology, specifically.

  13. 10 CFR 4.127 - Existing facilities.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Existing facilities. 4.127 Section 4.127 Energy NUCLEAR... 1973, as Amended Discriminatory Practices § 4.127 Existing facilities. (a) Accessibility. A recipient... make each of its existing facilities or every part of an existing facility accessible to and usable by...

  14. Do Elementary Particles Have an Objective Existence?

    OpenAIRE

    Nissenson, Bilha

    2007-01-01

    The formulation of quantum theory does not comply with the notion of objective existence of elementary particles. Objective existence independent of observation implies the distinguishability of elementary particles. In other words: If elementary particles have an objective existence independent of observations, then they are distinguishable. Or if elementary particles are indistinguishable then matter cannot have existence independent of our observation. This paper presents a simple deductio...

  15. David Barker: the revolution that anticipates existence

    Directory of Open Access Journals (Sweden)

    Italo Farnetani

    2014-01-01

    Full Text Available David Barker is the man who “anticipated" the existence of babies by focusing attention on the importance of the fetus and what takes place during intrauterine life. Barker was one of the physicians who in the last decades brought about the greatest changes in medicine, changes so important as to represent a veritable revolution in medical thought. According to Barker's studies, the embryo obviously has a genetic complement coming from the mother and father, but from the very first stages of development it begins to undergo the influence of the outside environment, just as occurs for adults whose biological, psychological and pathological aspects are influenced by the environment to a not well-established percentage between genetic complement and epigenetics. Much of our future lives as adults is decided in our mothers' wombs. If Barker's discovery was revolutionary from the cultural standpoint, it was even more so from the strictly medical one. Barker's research method was rigid from the methodological standpoint, but innovative and speculative in its working hypotheses, with a humanistic slant. Barker's idea has another practical corollary: it is evident that the role of obstetricians, perinatologists and neonatologists is more and more relevant in medicine and future prevention. Unquestionably, besides the enormous merits of his clinical research, among the benefits that Barker has contributed there is that of having helped us to see things from new points of view. Not only is the neonate (and even more so the fetus not an adult of reduced proportions, but perhaps the neonate is the "father" of the adult person.

  16. 34 CFR 104.22 - Existing facilities.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Existing facilities. 104.22 Section 104.22 Education... Accessibility § 104.22 Existing facilities. (a) Accessibility. A recipient shall operate its program or activity.... This paragraph does not require a recipient to make each of its existing facilities or every part of a...

  17. 45 CFR 1170.32 - Existing facilities.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Existing facilities. 1170.32 Section 1170.32... ASSISTED PROGRAMS OR ACTIVITIES Accessibility § 1170.32 Existing facilities. (a) Accessibility. A recipient... require a recipient to make each of its existing facilities or every part of a facility accessible to and...

  18. 45 CFR 605.22 - Existing facilities.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Existing facilities. 605.22 Section 605.22 Public... Accessibility § 605.22 Existing facilities. (a) Accessibility. A recipient shall operate each program or... existing facilities or every part of a facility accessible to and usable by qualified handicapped persons...

  19. 14 CFR 1251.301 - Existing facilities.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Existing facilities. 1251.301 Section 1251... HANDICAP Accessibility § 1251.301 Existing facilities. (a) Accessibility. A recipient shall operate each... existing facilities or every part of a facility accessible to and usable by handicapped persons. (b...

  20. 45 CFR 1151.22 - Existing facilities.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Existing facilities. 1151.22 Section 1151.22... Prohibited Accessibility § 1151.22 Existing facilities. (a) A recipient shall operate each program or... make each of its existing facilities or every part of a facility accessible to and usable by...

  1. 10 CFR 611.206 - Existing facilities.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Existing facilities. 611.206 Section 611.206 Energy... PROGRAM Facility/Funding Awards § 611.206 Existing facilities. The Secretary shall, in making awards to those manufacturers that have existing facilities, give priority to those facilities that are oldest or...

  2. Disparities in child mortality trends: what is the evidence from disadvantaged states in India? the case of Orissa and Madhya Pradesh.

    Science.gov (United States)

    Nguyen, Kim-Huong; Jimenez-Soto, Eliana; Dayal, Prarthna; Hodge, Andrew

    2013-06-27

    The Millennium Development Goals prompted renewed international efforts to reduce under-five mortality and measure national progress. However, scant evidence exists about the distribution of child mortality at low sub-national levels, which in diverse and decentralized countries like India are required to inform policy-making. This study estimates changes in child mortality across a range of markers of inequalities in Orissa and Madhya Pradesh, two of India's largest, poorest, and most disadvantaged states. Estimates of under-five and neonatal mortality rates were computed using seven datasets from three available sources--sample registration system, summary birth histories in surveys, and complete birth histories. Inequalities were gauged by comparison of mortality rates within four sub-state populations defined by the following characteristics: rural-urban location, ethnicity, wealth, and district. Trend estimates suggest that progress has been made in mortality rates at the state levels. However, reduction rates have been modest, particularly for neonatal mortality. Different mortality rates are observed across all the equity markers, although there is a pattern of convergence between rural and urban areas, largely due to inadequate progress in urban settings. Inter-district disparities and differences between socioeconomic groups are also evident. Although child mortality rates continue to decline at the national level, our evidence shows that considerable disparities persist. While progress in reducing under-five and neonatal mortality rates in urban areas appears to be levelling off, policies targeting rural populations and scheduled caste and tribe groups appear to have achieved some success in reducing mortality differentials. The results of this study thus add weight to recent government initiatives targeting these groups. Equitable progress, particularly for neonatal mortality, requires continuing efforts to strengthen health systems and overcome barriers

  3. Evidence appraisal: a scoping review, conceptual framework, and research agenda.

    Science.gov (United States)

    Goldstein, Andrew; Venker, Eric; Weng, Chunhua

    2017-11-01

    Critical appraisal of clinical evidence promises to help prevent, detect, and address flaws related to study importance, ethics, validity, applicability, and reporting. These research issues are of growing concern. The purpose of this scoping review is to survey the current literature on evidence appraisal to develop a conceptual framework and an informatics research agenda. We conducted an iterative literature search of Medline for discussion or research on the critical appraisal of clinical evidence. After title and abstract review, 121 articles were included in the analysis. We performed qualitative thematic analysis to describe the evidence appraisal architecture and its issues and opportunities. From this analysis, we derived a conceptual framework and an informatics research agenda. We identified 68 themes in 10 categories. This analysis revealed that the practice of evidence appraisal is quite common but is rarely subjected to documentation, organization, validation, integration, or uptake. This is related to underdeveloped tools, scant incentives, and insufficient acquisition of appraisal data and transformation of the data into usable knowledge. The gaps in acquiring appraisal data, transforming the data into actionable information and knowledge, and ensuring its dissemination and adoption can be addressed with proven informatics approaches. Evidence appraisal faces several challenges, but implementing an informatics research agenda would likely help realize the potential of evidence appraisal for improving the rigor and value of clinical evidence. © The Author 2017. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com

  4. World Population: U.N. on the Move but Grounds for Optimism Are Scant

    Science.gov (United States)

    Holden, Constance

    1974-01-01

    Discusses current trends and problems relating to world population, and focuses on action being taken by the United Nations. This year (1974) has been designated World Population Year, and will be highlighted by a conference in Bucharest in which all 130 member governments will meet to confront the issue of population control. (JR)

  5. Existence of equilibria in articulated bearings

    Science.gov (United States)

    Buscaglia, G.; Ciuperca, I.; Hafidi, I.; Jai, M.

    2007-04-01

    The existence of equilibrium solutions for a lubricated system consisting of an articulated body sliding over a flat plate is considered. Though this configuration is very common (it corresponds to the popular tilting-pad thrust bearings), the existence problem has only been addressed in extremely simplified cases, such as planar sliders of infinite width. Our results show the existence of at least one equilibrium for a quite general class of (nonplanar) slider shapes. We also extend previous results concerning planar sliders.

  6. Does the {sigma}(1580)((3)/(2)){sup -} resonance exist?

    Energy Technology Data Exchange (ETDEWEB)

    Olmsted, J.; Prakhov, S.; Manley, D.M.; Allgower, C.E.; Bekrenev, V.S.; Briscoe, W.J.; Clajus, M.; Comfort, J.R.; Craig, K.; Grosnick, D.; Isenhower, D.; Knecht, N.; Koetke, D.D.; Kozlenko, N.G.; Kruglov, S.; Kulbardis, A.A.; Lolos, G.; Lopatin, I.V.; Manweiler, R.; Marusic, A.; McDonald, S.; Nefkens, B.M.K.; Papandreou, Z.; Peaslee, D.C.; Phaisangittisakul, N.; Price, J.W.; Ramirez, A.F.; Sadler, M.; Shafi, A.; Spinka, H.; Stanislaus, T.D.S.; Starostin, A.; Staudenmaier, H.M.; Strakovsky, I.I.; Supek, I.; Tippens, W.B

    2004-05-20

    Precise new data for the reaction K{sup -}p{yields}{pi}{sup 0}{lambda} are presented in the c.m. energy range 1565 to 1600 MeV. Our analysis of these data sheds new light on claims for the {sigma}(1580)((3)/(2)){sup -} resonance, which (if it exists with the specified quantum numbers) must be an exotic baryon because of its very low mass. Our results show no evidence for this state.

  7. Does the Σ(1580)((3)/(2))- resonance exist?

    International Nuclear Information System (INIS)

    Olmsted, J.; Prakhov, S.; Manley, D.M.; Allgower, C.E.; Bekrenev, V.S.; Briscoe, W.J.; Clajus, M.; Comfort, J.R.; Craig, K.; Grosnick, D.; Isenhower, D.; Knecht, N.; Koetke, D.D.; Kozlenko, N.G.; Kruglov, S.; Kulbardis, A.A.; Lolos, G.; Lopatin, I.V.; Manweiler, R.; Marusic, A.; McDonald, S.; Nefkens, B.M.K.; Papandreou, Z.; Peaslee, D.C.; Phaisangittisakul, N.; Price, J.W.; Ramirez, A.F.; Sadler, M.; Shafi, A.; Spinka, H.; Stanislaus, T.D.S.; Starostin, A.; Staudenmaier, H.M.; Strakovsky, I.I.; Supek, I.; Tippens, W.B.

    2004-01-01

    Precise new data for the reaction K - p→π 0 Λ are presented in the c.m. energy range 1565 to 1600 MeV. Our analysis of these data sheds new light on claims for the Σ(1580)((3)/(2)) - resonance, which (if it exists with the specified quantum numbers) must be an exotic baryon because of its very low mass. Our results show no evidence for this state

  8. Sharing information among existing data sources

    Science.gov (United States)

    Ashley, W. R., III

    1999-01-01

    The sharing of information between law enforcement agencies is a premise for the success of all jurisdictions. A wealth of information resides in both the databases and infrastructures of local, state, and regional agencies. However, this information is often not available to the law enforcement professionals who require it. When the information is, available, individual investigators must not only know that it exists, but where it resides, and how to retrieve it. In many cases, these types of cross-jurisdictional communications are limited to personal relationships that result from telephone calls, faxes, and in some cases, e-mail. As criminal elements become more sophisticated and distributed, law enforcement agencies must begin to develop infrastructures and common sharing mechanisms that address a constantly evolving criminal threat. Historically, criminals have taken advantage of the lack of communication between law enforcement agencies. Examples of this are evident in the search for stolen property and monetary dealings. Pawned property, cash transactions, and failure to supply child support are three common cross- jurisdictional crimes that could be better enforced by strengthening the lines of communication. Criminal behavior demonstrates that it is easier to profit from their actions by dealing in separate jurisdictions. For example, stolen property is sold outside of the jurisdiction of its origin. In most cases, simply traveling a short distance to the adjoining county or municipality is sufficient to ensure that apprehension of the criminal or seizure of the stolen property is highly unlikely. In addition to the traditional burglar, fugitives often sell or pawn property to finance their continued evasion from the law. Sharing of information in a rapid manner would increase the ability of law enforcement personnel to track and capture fugitives, as well as criminals. In an example to combat this threat, the State of Florida recently acted on the need to

  9. 47 CFR 17.17 - Existing structures.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Existing structures. 17.17 Section 17.17... STRUCTURES Federal Aviation Administration Notification Criteria § 17.17 Existing structures. (a) The requirements found in § 17.23 relating to painting and lighting of antenna structures shall not apply to those...

  10. 10 CFR 1040.72 - Existing facilities.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Existing facilities. 1040.72 Section 1040.72 Energy... § 1040.72 Existing facilities. (a) Accessibility. A recipient shall operate any program or activity to... facilities or every part of a facility accessible to and useable by handicapped persons. (b) Methods. A...

  11. 45 CFR 84.22 - Existing facilities.

    Science.gov (United States)

    2010-10-01

    ... HANDICAP IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Accessibility § 84.22 Existing facilities. (a) Accessibility. A recipient shall operate its program or activity so that when each part is..., welfare, or other social services at alternate accessible sites, alteration of existing facilities and...

  12. Financial gap calculations for existing cogeneration 2008

    International Nuclear Information System (INIS)

    Hers, S.J.; Wetzels, W.; Seebregts, A.J.; Van der Welle, A.J.

    2008-05-01

    The Dutch SDE (abbreviation for the renewable energy incentive) subsidy scheme promotes the reduction of CO2 emissions which results from the use of Combined Heat and Power (CHP) plants. This report calculates the profitability of operation of existing CHP plants. This information can be used for decision making on the SDE subsidy for existing CHP plants in 2008 [nl

  13. On the existence of consistent price systems

    DEFF Research Database (Denmark)

    Bayraktar, Erhan; Pakkanen, Mikko S.; Sayit, Hasanjan

    2014-01-01

    We formulate a sufficient condition for the existence of a consistent price system (CPS), which is weaker than the conditional full support condition (CFS). We use the new condition to show the existence of CPSs for certain processes that fail to have the CFS property. In particular this condition...

  14. [Evidence and Evidence Gaps - an Introduction].

    Science.gov (United States)

    Dreier, G; Löhler, J

    2016-04-01

    Treating patients requires the inclusion of existing evidence in any health care decision, to be able to choose the best diagnosis or treatment measure or to make valid prognosis statements for a particular patient in consideration of the physician's own expertise.The basis are clinical trials, the results of which are ideally gathered in systematic reviews, rated, summarized and published. In addition to the GCP (Good Clinical Practice)-compliant planning, conducting and analysis of clinical studies it is essential, that all study results are made publicly available, in order to avoid publication bias. This includes the public registration of planned and discontinued trials. In the last 25 years, the evidence-based medicine (EbM) has increasingly found its way into clinical practice and research. Here EbM is closely associated with the names Archibald Cochrane and David Sackett. In Germany, both the German Cochrane Centre (DCZ) and the network of evidence-based medicine (DNEbM) were established approximately 15 years ago. In the international Cochrane Collaboration clinicians and other scientists like statisticians interdisciplinary work side by side to develop the methods of evidence-based medicine and to address the topics of evidence generation and processing as well as the transfer of knowledge. Challenge: Existing evidence primarily serves doctors to support their decision-making, but is also the basis for providing scientific proof for a health care intervention's benefit to patients and ultimately payers/health insurances. The closure of existing evidence gaps requires substantial human and financial resources, a complex organizational structure and can only succeed with the involvement of clinical and methodological expertise and specific knowledge in the field of clinical research. In addition, the knowledge must be transferred into practice, using journals, guidelines, conferences, databases, information portals with processed evidence and not least the

  15. The existence of trajectories joining critical points

    International Nuclear Information System (INIS)

    Yu Shuxiang.

    1985-01-01

    In this paper, using the notion of an isolating block and the concept of canonical regions, three existence criteria of trajectories connecting a pair of critical points of planar differential equations are given. (author)

  16. Pre-Existing Condition Insurance Plan Data

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Affordable Care Act created the new Pre-Existing Condition Insurance Plan (PCIP) program to make health insurance available to Americans denied coverage by...

  17. Seismic assessment of existing nuclear chemical plants

    International Nuclear Information System (INIS)

    Merriman, P.A.

    1997-01-01

    This paper outlines the generic approach to the seismic assessment of existing structures. It describes the role of the safety case in determining the studies carried out by the functional departments on individual projects. There is an emphasis on the role of existing information and material tests to provide realistic properties for analysis to account for possible degradation effects. Finally, a case study of a concrete containment cell is shown to illustrate the approach. (author)

  18. Solar Panel Installations on Existing Structures

    OpenAIRE

    Tim D. Sass; Pe; Leed

    2013-01-01

    The rising price of fossil fuels, government incentives and growing public aware-ness for the need to implement sustainable energy supplies has resulted in a large in-crease in solar panel installations across the country. For many sites the most eco-nomical solar panel installation uses existing, southerly facing rooftops. Adding solar panels to an existing roof typically means increased loads that must be borne by the building-s structural elements. The structural desig...

  19. The global existence problem in general relativity

    CERN Document Server

    Andersson, L

    2000-01-01

    We survey some known facts and open questions concerning the global properties of 3+1 dimensional space--times containing a compact Cauchy surface. We consider space--times with an $\\ell$--dimensional Lie algebra of space--like Killing fields. For each $\\ell \\leq 3$, we give some basic results and conjectures on global existence and cosmic censorship. For the case of the 3+1 dimensional Einstein equations without symmetries, a new small data global existence result is announced.

  20. Gravitational Waves: The Evidence Mounts

    Science.gov (United States)

    Wick, Gerald L.

    1970-01-01

    Reviews the work of Weber and his colleagues in their attempts at detecting extraterrestial gravitational waves. Coincidence events recorded by special detectors provide the evidence for the existence of gravitational waves. Bibliography. (LC)

  1. Existence test for asynchronous interval iterations

    DEFF Research Database (Denmark)

    Madsen, Kaj; Caprani, O.; Stauning, Ole

    1997-01-01

    In the search for regions that contain fixed points ofa real function of several variables, tests based on interval calculationscan be used to establish existence ornon-existence of fixed points in regions that are examined in the course ofthe search. The search can e.g. be performed...... as a synchronous (sequential) interval iteration:In each iteration step all components of the iterate are calculatedbased on the previous iterate. In this case it is straight forward to base simple interval existence and non-existencetests on the calculations done in each step of the iteration. The search can also...... on thecomponentwise calculations done in the course of the iteration. These componentwisetests are useful for parallel implementation of the search, sincethe tests can then be performed local to each processor and only when a test issuccessful do a processor communicate this result to other processors....

  2. Seismic reevaluation of existing nuclear power plants

    International Nuclear Information System (INIS)

    Hennart, J.C.

    1978-01-01

    The codes and regulations governing Nuclear Power Plant seismic analysis are continuously becoming more stringent. In addition, design ground accelerations of existing plants must sometimes be increased as a result of discovery of faulting zones or recording of recent earthquakes near the plant location after plant design. These new factors can result in augmented seismic design criteria. Seismic reanalysius of the existing Nuclear Power Plant structures and equipments is necessary to prevent the consequences of newly postulated accidents that could cause undue risk to the health or safety of the public. This paper reviews the developments of seismic analysis as applied to Nuclear Power Plants and the methods used by Westinghouse to requalify existing plants to the most recent safety requirements. (author)

  3. The Existence of Public Protection Unit

    Directory of Open Access Journals (Sweden)

    Moh. Ilham A. Hamudy

    2014-12-01

    Full Text Available This article is about the Public Protection Unit (Satlinmas formerly known as civil defence (Hansip. This article is a summary of the results of the desk study and fieldwork conducted in October-November 2013 in the town of Magelang and Surabaya. This study used descriptive qualitative approach to explore the combined role and existence Satlinmas. The results of the study showed, the existence of the problem Satlinmas still leave many, including, first, the legal basis for the establishment of Satlinmas. Until now, there has been no new regulations governing Satlinmas. Existing regulations are too weak and cannot capture the times. Second, the formulation of concepts and basic tasks and functions Satlinmas overlap with other institutions. Third, Satlinmas image in society tend to fade and abused. Fourth, Satlinmas incorporation into the Municipal Police deemed not appropriate, because different philosophy.

  4. Radiation protection programme for existing exposure situation

    International Nuclear Information System (INIS)

    Ramadhani, Hilali Hussein

    2016-04-01

    This study was conducted to develop the Radiation protection Programme (RPP) to ensure that measures are in place for protection of individuals from the existing source of exposure. The study established a number of protective and remedial actions to be considered by the responsible regulatory Authority, licensee for existing exposure in workplace and dwellings. Tanzania is endowed with a number NORMs processing industries with an experience of uncontrolled exploration and extraction of minerals and the use of unsafe mining methods leading to severe environmental damage and appalling living conditions in the mining communities. Some of NORMs industries have been abandoned due to lack of an effect management infrastructure. The residual radioactive materials have been found to be the most import source of existing exposure resulted from NORMs industries. The Radon gas and its progeny have also been found to be a source of existing exposure from natural source as well as the major source of risk and health effects associated with existing exposure situation. The following measures have been discovered to play a pivotal role in avoiding or reducing the source of exposure to individuals such as restriction of the use of the construction materials, restriction on the consumption of foodstuffs and restriction on the access to the land and buildings, the removal of the magnitude of the source in terms of activity concentration as well as improvement of ventilation in dwellings. Therefore, the regulatory body (Tanzania Atomic Energy Commission) should examine the major areas outlined in the established RRP for existing exposure situation resulted from the NORMs industries and natural sources so as to develop strategies that will ensure the adequate protection of members of the public and the environment as well as guiding operating organizations to develop radiation protection and safety measures for workers. (au)

  5. Herbal Supplements for Prostate Enlargement: Current State of the Evidence.

    Science.gov (United States)

    Nabavizadeh, Reza; Zangi, Mahdi; Kim, Michelle M; Yavari Bejestani, Maryam; Tabatabaei, Shahin

    2018-02-01

    To provide a comprehensive review of the current state of herbal supplement market for lower urinary tract symptoms (LUTS) and correlate the ingredients of each product with available scientific evidence. Twenty-seven products from Amazon.com that were advertised as herbal supplements for LUTS and had listed their active ingredients were selected. Active ingredients were reviewed on Google Scholar. Product price, warranty, and consumer review information were also collected. A total of 58 unique active ingredients were identified. The mean number of ingredients was 8.26 (standard deviation 5.25). Whereas 17 (63%) products had an ingredient with a systematic review to support their use, 20 (74%) had an ingredient with conflicting evidence based on systematic reviews. Out of the supplements that contained ingredients supported by literature, all (100%) products simultaneously had other ingredients with no, conflicting, or refuting evidence. There was no (0%) product that contained only scientifically proven ingredients. There is no scientific study to evaluate these supplements as a whole. Despite the widespread use of herbal supplements for LUTS, there is scant scientific evidence to support their safety and efficacy. Lack of adequate regulation and government support for research and development are some of the factors that disincentivize researchers to study safety and efficacy of these products. We encourage physicians to warn their patients on the lack of adequate evidence to support the safety and efficacy of many of these supplements. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. Foucault, Counselling and the Aesthetics of Existence

    Science.gov (United States)

    Peters, Michael A.

    2005-01-01

    Michel Foucault was drawn late in life to study the "arts of the self" in Greco-Roman culture as a basis, following Nietzsche, for what he called an "aesthetics of existence." By this, he meant a set of creative and experimental processes and techniques by which an individual turns him- or herself into a work of art. For Nietzsche, it was above…

  7. Conditions for the Existence of Market Equilibrium.

    Science.gov (United States)

    Bryant, William D. A.

    1997-01-01

    Maintains that most graduate-level economics textbooks rarely mention the need for consumers to be above their minimum wealth position as a condition for market equilibrium. Argues that this omission leaves students with a mistaken sense about the range of circumstances under which market equilibria can exist. (MJP)

  8. 22 CFR 142.16 - Existing facilities.

    Science.gov (United States)

    2010-04-01

    ... OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Accessibility § 142.16 Existing facilities. (a) Accessibility. A recipient shall operate each program or activity to which this part applies so that when each...., telecommunication device for the deaf) redesign of equipment, reassignment of classes or other services to...

  9. Transportation capabilities of the existing cask fleet

    International Nuclear Information System (INIS)

    Johnson, P.E.; Joy, D.S.; Wankerl, M.W.

    1991-01-01

    This paper describes a number of scenarios estimating the amount of spent nuclear fuel that could be transported to a Monitored Retrievable Storage (MRS) Facility by various combinations of existing cask fleets. To develop the scenarios, the data provided by the Transportation System Data Base (TSDB) were modified to reflect the additional time for cask turnaround resulting from various startup and transportation issues. With these more realistic speed and cask-handling assumptions, the annual transportation capability of a fleet consisting of all of the existing casks is approximately 46 metric tons of uranium (MTU). The most likely fleet of existing casks that would be made available to the Department of Energy (DOE) consists of two rail, three overweight truck, and six legal weight truck casks. Under the same transportation assumptions, this cask fleet is capable of approximately transporting 270 MTU/year. These ranges of capability is a result of the assumptions pertaining to the number of casks assumed to be available. It should be noted that this assessment assumes additional casks based on existing certifications are not fabricated. 5 refs., 4 tabs

  10. Conservation and Development Options existing on Uluguru ...

    African Journals Online (AJOL)

    Effective management of projects on Uluguru Mountains requires that both development and conservation options are weighed and that opportunities and challenges are considered. This study identified various conservation and development options existing on Uluguru Mountains and assessed the perceptions of the local ...

  11. Transportation capabilities of the existing cask fleet

    International Nuclear Information System (INIS)

    Johnson, P.E.; Wankerl, M.W.; Joy, D.S.

    1991-01-01

    This paper describes a number of scenarios estimating the amount of spent nuclear fuel that could be transported to a Monitored Retrievable Storage (MRS) Facility by various combinations of existing cask fleets. To develop the scenarios, the data provided by the Transportation System Data Base (TSDB) were modified to reflect the additional time for cask turnaround resulting from various startup and transportation issues. With these more realistic speed and cask-handling assumptions, the annual transportation capability of a fleet consisting of all of the existing casks is approximately 465 metric tons of uranium (MTU). The most likely fleet of existing casks that would be made available to the DOE consists of two rail, three overweight truck, and six legal weight truck casks. Under the same transportation assumptions, this cask fleet is capable of approximately transporting 270 MTU/year. These ranges of capability is a result of the assumptions pertaining to the number of casks assumed to be available. It should be noted that this assessment assumes additional casks based on existing certifications are not fabricated

  12. Does the Kuleshov Effect really Exist?

    DEFF Research Database (Denmark)

    Barratt, Daniel; Cabak Rédei, Anna

    2013-01-01

    with a doll, a dead woman in a coffin, and a bowl of soup; the viewers of the three sequences were reported to have perceived Mozhukin’s face as expressing happiness, sadness, and hunger/thoughtfulness respectively. It is not clear, however, whether or not the socalled “Kuleshov effect” really exists...

  13. COMPARATIVE ANALYSIS OF SOME EXISTING KINETIC MODELS ...

    African Journals Online (AJOL)

    The biosorption of three heavy metal ions namely; Zn2+, Cu2+ and Mn2+ using five microorganisms namely; Bacillus circulans, Pseudomonas aeruginosa, Staphylococcus xylosus, Streptomyces rimosus and Yeast (Saccharomyces sp.) were studied. In this paper, the effectiveness of six existing and two proposed kinetic ...

  14. Do ‘African’ universities exist?

    DEFF Research Database (Denmark)

    Jensen, Stig; Adriansen, Hanne Kirstine; Madsen, Lene Møller

    2015-01-01

    This chapter provides a background for understanding the book. We outline some of the debates in which the individual chapters are situated and thereby show how the book contributes to and fills gaps in existing research. After providing a short history of African universities, the chapter subseq...

  15. Do Biopositive Effects of Ionizing Radiations Exist

    International Nuclear Information System (INIS)

    Broda, E.

    1983-01-01

    The claim that radiations, e.g, in spas, can have biopositive actions on humans is unproven and unplausible. It also conflicts with the contents of the standard handbooks and with national legislation everywhere. Further, stimulation of plants by radiation is badly reproducible. But even if existing it need not be beneficial to the plant itself ("selfpositive"). (author)

  16. Repurposing Existing Material for Performance Support.

    Science.gov (United States)

    Harvey, Francis A.; Nelson, Adam

    1995-01-01

    Presents an overview of performance support systems (PSS), describes their role in promoting productivity in agile organizations, and discusses issues related to developing effective performance support using existing orientation, training, or procedural manuals. Topics include strategic principles of agility, and adding value when incorporating…

  17. Global existence proof for relativistic Boltzmann equation

    International Nuclear Information System (INIS)

    Dudynski, M.; Ekiel-Jezewska, M.L.

    1992-01-01

    The existence and causality of solutions to the relativistic Boltzmann equation in L 1 and in L loc 1 are proved. The solutions are shown to satisfy physically natural a priori bounds, time-independent in L 1 . The results rely upon new techniques developed for the nonrelativistic Boltzmann equation by DiPerna and Lions

  18. 38 CFR 18.422 - Existing facilities.

    Science.gov (United States)

    2010-07-01

    ... THE CIVIL RIGHTS ACT OF 1964 Nondiscrimination on the Basis of Handicap Accessibility § 18.422 Existing facilities. (a) Accessibility. A recipient shall operate each program or activity to which this... visits, delivery of health, or other social services at alternate accessible sites, alteration of...

  19. Developing an Actuarial Track Utilizing Existing Resources

    Science.gov (United States)

    Rodgers, Kathy V.; Sarol, Yalçin

    2014-01-01

    Students earning a degree in mathematics often seek information on how to apply their mathematical knowledge. One option is to follow a curriculum with an actuarial emphasis designed to prepare students as an applied mathematician in the actuarial field. By developing only two new courses and utilizing existing courses for Validation by…

  20. 7 CFR 1718.52 - Existing mortgages.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Existing mortgages. 1718.52 Section 1718.52 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE LOAN SECURITY DOCUMENTS FOR ELECTRIC BORROWERS Mortgage for Distribution Borrowers § 1718.52...

  1. Transforming existing content into reusable Learning Objects

    NARCIS (Netherlands)

    Doorten, Monique; Giesbers, Bas; Janssen, José; Daniels, Jan; Koper, Rob

    2003-01-01

    Please cite as: Doorten, M., Giesbers, B., Janssen, J., Daniëls, J, & Koper, E.J.R., (2004). Transforming existing content into reusable learning objects. In R. McGreal, Online Education using Learning Objects (pp. 116-127). London: RoutledgeFalmer.

  2. Psychology's struggle for existence: Second edition, 1913.

    Science.gov (United States)

    Wundt, Wilhelm; Lamiell, James T

    2013-08-01

    Presents an English translation of Wilhelm Wundt's Psychology's struggle for existence: Second edition, 1913, by James T. Lamiell in August, 2012. In his essay, Wundt advised against the impending divorce of psychology from philosophy. (PsycINFO Database Record (c) 2013 APA, all rights reserved).

  3. Altering existing buildings in the UK

    International Nuclear Information System (INIS)

    Roberts, Simon

    2008-01-01

    The profiles of both existing housing and existing public and commercial buildings show that many have very poor thermal efficiency. The UK housing stock is replaced at a low rate of about 1% a year, so to cut energy use it is essential to address the challenges of existing buildings. This will involve reducing energy demand through passive measures such as retrofitted insulation, replacement of windows and proper airtightness, while ensuring adequate ventilation. Active measures include upgrading improved boilers and adding locally produced energy from wind, biomass, solar power and other sources. The introduction of Display Energy Certificates will increase energy awareness but there will also need to be a programme of increased demolition for the worst-performing homes. In addition, buildings will need to be adapted to cope with worse weather, higher temperatures and increased flood risk as climate change takes effect. Overheating, rather than excessive cold, is set to become a growing problem for householders and employees in existing UK buildings

  4. Adding Semantic Support to Existing UDDI Infrastructure

    National Research Council Canada - National Science Library

    Luo, Jim; Montrose, Bruce; Kang, Myong

    2005-01-01

    .... The advantage is that it is completely backward compatible. The add-on modules only need to be installed on the clients of users who wish to take advantage of semantic markups. They can be integrated seamlessly into existing systems and operations without any modification of the infrastructure.

  5. Evidence and evidence gaps - an introduction.

    Science.gov (United States)

    Dreier, Gabriele; Löhler, Jan

    2016-01-01

    Background: Medical treatment requires the implementation of existing evidence in the decision making process in order to be able to find the best possible diagnostic, therapeutic or prognostic measure for the individual patient based on the physician's own expertise. Clinical trials form the evidence base and ideally, their results are assembled, analyzed, summarized, and made available in systematic review articles. Beside planning, conducting, and evaluating clinical trials in conformity with GCP (good clinical practice), it is essential that all results of conducted studies are publicly available in order to avoid publication bias. This includes also the public registration of planned and cancelled trials. History: During the last 25 years, evidence-based medicine became increasingly important in medical care and research. It is closely associated with the names of Archibald Cochrane and David Sackett. About 15 years ago, the Deutsche Cochrane Zentrum (Cochrane Germany) and the Deutsche Netzwerk Evidenzbasierte Medizin e.V. (German Network for Evidence-based Medicine, DNEbM) were founded in Germany. In the International Cochrane Collaboration, clinicians and methodologists come together on an interdisciplinary level to further develop methods of evidence-based medicine and to discuss the topics of evidence generation and processing as well as knowledge transfer. Problem: Evidence is particularly important for physicians in the process of decision making, however, at the same time it is the base of a scientific proof of benefit for the patient and finally for the payers in health care. The closure of evidence gaps requires enormously high staff and financial resources, significant organizational efforts, and it is only successful when clinical and methodical expertise as well as specific knowledge in the field of clinical research are included. On the other hand, the knowledge has to be transferred into practice. For this purpose, practice guidelines, meetings

  6. Does Lyme disease exist in Australia?

    Science.gov (United States)

    Collignon, Peter J; Lum, Gary D; Robson, Jennifer Mb

    2016-11-07

    There is no convincing evidence that classic Lyme disease occurs in Australia, nor is there evidence that the causative agent, Borrelia burgdorferi, is found in Australian animals or ticks. Lyme disease, however, can be acquired overseas but diagnosed in Australia; most people presenting with laboratory-confirmed Lyme disease in Australia were infected in Europe. Despite the lack of evidence that Lyme disease can be acquired in Australia, growing numbers of patients, their supporters, and some politicians demand diagnoses and treatment according to the protocols of the "chronic Lyme disease" school of thought. Antibiotic therapy for chronic "Lyme disease-like illness" can cause harm to both the individual (eg, cannula-related intravenous sepsis) and the broader community (increased antimicrobial resistance rates). Until there is strong evidence from well performed clinical studies that bacteria present in Australia cause a chronic debilitating illness that responds to prolonged antibiotics, treating patients with "Lyme disease-like illness" with prolonged antibiotic therapy is unjustified, and is likely to do much more harm than good.

  7. Essence and Existence in Avicenna and Averroes

    Directory of Open Access Journals (Sweden)

    Belo, Catarina

    2009-12-01

    Full Text Available This article explores the views on existence of medieval Muslim philosophers Avicenna (d. 1037 and Averroes (d. 1198, whose works followed closely the philosophy of Aristotle. In addition to the Aristotelian influence, which permeated all medieval Islamic philosophy, Avicenna and Averroes were also inspired by Islamic theology, known in Arabic as kalām. The distinction between essence and existence is one of the most central and controversial aspects of Avicenna’s philosophy, together with his claim that existence is an accident. Averroes in turn has a radically different conception of existence, identifying it with existing beings rather than considering it as something in itself. With the Latin translation of Avicenna’s metaphysical works in the 12th century, the Avicennian distinction went on to shape much of the debate on existence in medieval Scholastic philosophy and beyond. This article assesses the meaning of the distinction in Avicenna as well as Averroes’ criticism. In explicating their radically different views on existence, it also touches on later discussions concerning existence, for example the issue whether existence is a predicate, in the Modern Age.

    El presente artículo explora las percepciones sobre la existencia de los filósofos medievales musulmanes Avicena (m. 1037 y Averroes (m. 1198, cuyas obras se encuentran muy próximas a la filosofía de Aristóteles. Además de la influencia aristotélica, que caló en toda la filosofía islámica medieval, Avicena y Averroes estuvieron inspirados por la teología islámica, conocida en árabe como Kalām. La distinción entre esencia y existencia es uno de los más fundamentales y controvertidos aspectos de la filosofía de Avicena junto a su aseveración de que la existencia es un accidente. Averroes, en cambio, concibe de forma radicalmente diferente la existencia, identificándola con los seres existentes más que considerarla como algo en

  8. Overview of Existing Wind Energy Ordinances

    Energy Technology Data Exchange (ETDEWEB)

    Oteri, F.

    2008-12-01

    Due to increased energy demand in the United States, rural communities with limited or no experience with wind energy now have the opportunity to become involved in this industry. Communities with good wind resources may be approached by entities with plans to develop the resource. Although these opportunities can create new revenue in the form of construction jobs and land lease payments, they also create a new responsibility on the part of local governments to ensure that ordinances will be established to aid the development of safe facilities that will be embraced by the community. The purpose of this report is to educate and engage state and local governments, as well as policymakers, about existing large wind energy ordinances. These groups will have a collection of examples to utilize when they attempt to draft a new large wind energy ordinance in a town or county without existing ordinances.

  9. Co-existence in multispecies biofilm communities

    DEFF Research Database (Denmark)

    Røder, Henriette Lyng

    of these emergent properties which are relevant to as diverse areas as clinical settings and natural systems. In this thesis, I have attempted to contribute to our knowledge on the multispecies interactions with a special focus on biofilm communities. I was especially interested in how co-existing species affect...... each other and in understanding the key mechanisms and interactions involved. In the introduction of this thesis the most important concepts of multi-species interactions and biofilm development are explained. After this the topic changes to the various ways of examining community interactions...... and production. The analysis was further extended in manuscript 3, in which the effect of social interac-tions on biofilm formation in multispecies co-cultures isolated from a diverse range of environments was examined. The question raised was whether the interspecific interactions of co-existing bacteria...

  10. Partial Cooperative Equilibria: Existence and Characterization

    Directory of Open Access Journals (Sweden)

    Amandine Ghintran

    2010-09-01

    Full Text Available We study the solution concepts of partial cooperative Cournot-Nash equilibria and partial cooperative Stackelberg equilibria. The partial cooperative Cournot-Nash equilibrium is axiomatically characterized by using notions of rationality, consistency and converse consistency with regard to reduced games. We also establish sufficient conditions for which partial cooperative Cournot-Nash equilibria and partial cooperative Stackelberg equilibria exist in supermodular games. Finally, we provide an application to strategic network formation where such solution concepts may be useful.

  11. Does evaporation paradox exist in China?

    Directory of Open Access Journals (Sweden)

    Z. T. Cong

    2009-03-01

    Full Text Available One expected consequence of global warming is the increase in evaporation. However, lots of observations show that the rate of evaporation from open pans of water has been steadily decreasing all over the world in the past 50 years. The contrast between expectation and observation is called "evaporation paradox". Based on data from 317 weather stations in China from 1956 to 2005, the trends of pan evaporation and air temperature were obtained and evaporation paradox was analyzed. The conclusions include: (1 From 1956 to 2005, pan evaporation paradox existed in China as a whole while pan evaporation kept decreasing and air temperature became warmer and warmer, but it does not apply to Northeast and Southeast China; (2 From 1956 to 1985, pan evaporation paradox existed narrowly as a whole with unobvious climate warming trend, but it does not apply to Northeast China; (3 From 1986 to 2005, in the past 20 years, pan evaporation paradox did not exist for the whole period while pan evaporation kept increasing, although it existed in South China. Furthermore, the trend of other weather factors including sunshine duration, windspeed, humidity and vapor pressure deficit, and their relations with pan evaporation are discussed. As a result, it can be concluded that pan evaporation decreasing is caused by the decreasing in radiation and wind speed before 1985 and pan evaporation increasing is caused by the decreasing in vapor pressure deficit due to strong warming after 1986. With the Budyko curve, it can be concluded that the actual evaporation decreased in the former 30 years and increased in the latter 20 year for the whole China.

  12. Existence and Comparability of data sources

    OpenAIRE

    KUHNIMHOF, T; ARMOOGUM, J

    2007-01-01

    The deliverable at hand comprises a comprehensive overview over existing data sources which can be used for analysis of long distance travel demand. This encompasses both national and international data sources with a focus on household travel surveys. Three types of relevant surveys were identified: - National travel surveys with focus on daily mobility - Travel survey elements dedicated to long distance mobility - Long distance travel surveys. RAPPORT DE CONTRAT

  13. Transgender Parenting: A Review of Existing Research

    OpenAIRE

    Stotzer, Rebecca L; Herman, Jody L; Hasenbush, Amira

    2014-01-01

    The authors of this report reviewed 51 studies that analyze data about transgender parents. This report reviews the existing research on the prevalence and characteristics of transgender people who are parents, the quality of relationships between transgender parents and their children, outcomes for children with a transgender parent, and the reported needs of transgender parents. Overall, the authors found that substantial numbers of transgender people are parents, though at rates below the ...

  14. Streamlining Research by Using Existing Tools

    OpenAIRE

    Greene, Sarah M.; Baldwin, Laura-Mae; Dolor, Rowena J.; Thompson, Ella; Neale, Anne Victoria

    2011-01-01

    Over the past two decades, the health research enterprise has matured rapidly, and many recognize an urgent need to translate pertinent research results into practice, to help improve the quality, accessibility, and affordability of U.S. health care. Streamlining research operations would speed translation, particularly for multi-site collaborations. However, the culture of research discourages reusing or adapting existing resources or study materials. Too often, researchers start studies and...

  15. Complex interventions required to comprehensively educate allied health practitioners on evidence-based practice

    Directory of Open Access Journals (Sweden)

    Dizon JM

    2011-05-01

    Full Text Available Janine Margarita Dizon1,2, Karen Grimmer-Somers11International Centre for Allied Health Evidence, University of South Australia, Adelaide, SA, Australia; 2University of Santo Tomas, Manila, PhilippinesAbstract: There is currently no strong evidence regarding the most effective training approach for allied health professionals that will support them to consistently apply the best research evidence in daily practice. Current evidence-based practice training tends to be 'one size fits all', and is unlikely to be appropriate for all allied health disciplines because of the variability in their tasks and scope of practice. The scant body of evidence regarding the effectiveness of evidence-based practice training for allied health practitioners provides some support for improving knowledge and skills, but equivocal evidence about influencing behaviors and attitudes. We propose a new model of evidence-based practice training, based on the concept of complex interventions reported in the literature. We believe that by offering training in evidence-based practice based on complex interventions relevant to the needs of the attendees, using fixed and variable components, there may be greater success in significantly influencing knowledge skills, attitudes, and behaviors.Keywords: complex interventions, evidence-based practice training, allied health

  16. Evidence logics with relational evidence

    DEFF Research Database (Denmark)

    Baltag, Alexandru; Occhipinti, Andrés

    2017-01-01

    We introduce a family of logics for reasoning about relational evidence: evidence that involves an ordering of states in terms of their relative plausibility. We provide sound and complete axiomatizations for the logics. We also present several evidential actions and prove soundness...

  17. Existing and new techniques in uranium exploration

    International Nuclear Information System (INIS)

    Bowie, S.H.U.; Cameron, J.

    1976-01-01

    The demands on uranium exploration over the next 25 years will be very great indeed and will call for every possible means of improvement in exploration capability. The first essential is to increase geological knowledge of the mode of occurrence of uranium ore deposits. The second is to improve existing exploration techniques and instrumentation while, at the same time, promoting research and development on new methods to discover uranium ore bodies on the earth's surface and at depth. The present symposium is an effort to increase co-operation and the exchange of information in the critical field of uranium exploration techniques and instrumentation. As an introduction to the symposium a brief review is presented, firstly of what can be considered as existing techniques and, secondly, of techniques which have not yet been used on an appreciable scale. Some fourteen techniques used over the last 30 years are identified and their appropriate application, advantages and limitations are briefly summarized and the possibilities of their further development considered. The aim of future research on new techniques, in addition to finding new ways and means of identifying surface deposits, should be mainly directed to devising methods and instrumentation capable of detecting buried ore bodies that do not give a gamma signal at the surface. To achieve this aim, two contributory factors are essential: adequate financial support for research and development and increased specialized training in uranium exploration and instrumentation design. The papers in this symposium describe developments in the existing techniques, proposals for future research and development and case histories of exploration programmes

  18. Does the Kuleshov Effect Really Exist?

    DEFF Research Database (Denmark)

    Barratt, Daniel; Rédei, Anna Cabak; Innes-Ker, Åse

    2016-01-01

    to replicate Kuleshov’s original experiment using an improved experimental design. In a behavioral and eye tracking study, 36 participants were each presented with 24 film sequences of neutral faces across six emotional conditions. For each film sequence, the participants were asked to evaluate the emotion...... of the target person in terms of valence, arousal, and category. The participants’ eye movements were recorded throughout. The results suggest that some sort of Kuleshov effect does in fact exist. For each emotional condition, the participants tended to choose the appropriate category more frequently than...... between the emotional conditions....

  19. Energy Savings Measure Packages. Existing Homes

    Energy Technology Data Exchange (ETDEWEB)

    Casey, Sean [National Renewable Energy Lab. (NREL), Golden, CO (United States); Booten, Chuck [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2011-11-01

    This document presents the most cost effective Energy Savings Measure Packages (ESMP) for existing mixed-fuel and all electric homes to achieve 15% and 30% savings for each BetterBuildings grantee location across the United States. These packages are optimized for minimum cost to homeowners for source energy savings given the local climate and prevalent building characteristics (i.e. foundation types). Maximum cost savings are typically found between 30% and 50% energy savings over the reference home; this typically amounts to $300 - $700/year.

  20. Analysis of field errors in existing undulators

    International Nuclear Information System (INIS)

    Kincaid, B.M.

    1990-01-01

    The Advanced Light Source (ALS) and other third generation synchrotron light sources have been designed for optimum performance with undulator insertion devices. The performance requirements for these new undulators are explored, with emphasis on the effects of errors on source spectral brightness. Analysis of magnetic field data for several existing hybrid undulators is presented, decomposing errors into systematic and random components. An attempts is made to identify the sources of these errors, and recommendations are made for designing future insertion devices. 12 refs., 16 figs

  1. Digital evidence

    Directory of Open Access Journals (Sweden)

    Lukić Tatjana

    2012-01-01

    Full Text Available Although computer makes human activities faster and easier, innovating and creating new forms of work and other kinds of activities, it also influenced the criminal activity. The development of information technology directly affects the development of computer forensics without which, it can not even imagine the discovering and proving the computer offences and apprehending the perpetrator. Information technology and computer forensic allows us to detect and prove the crimes committed by computer and capture the perpetrators. Computer forensics is a type of forensics which can be defined as a process of collecting, preserving, analyzing and presenting digital evidence in court proceedings. Bearing in mind, that combat against crime, in which computers appear as an asset or object of the offense, requires knowledge of digital evidence as well as specific rules and procedures, the author in this article specifically addresses the issues of digital evidence, forensic (computer investigation, specific rules and procedures for detecting, fixing and collecting digital evidence and use of this type of evidence in criminal proceedings. The author also delas with international standards regarding digital evidence and cyber-space investigation.

  2. Existence families, functional calculi and evolution equations

    CERN Document Server

    deLaubenfels, Ralph

    1994-01-01

    This book presents an operator-theoretic approach to ill-posed evolution equations. It presents the basic theory, and the more surprising examples, of generalizations of strongly continuous semigroups known as 'existent families' and 'regularized semigroups'. These families of operators may be used either to produce all initial data for which a solution in the original space exists, or to construct a maximal subspace on which the problem is well-posed. Regularized semigroups are also used to construct functional, or operational, calculi for unbounded operators. The book takes an intuitive and constructive approach by emphasizing the interaction between functional calculus constructions and evolution equations. One thinks of a semigroup generated by A as etA and thinks of a regularized semigroup generated by A as etA g(A), producing solutions of the abstract Cauchy problem for initial data in the image of g(A). Material that is scattered throughout numerous papers is brought together and presented in a fresh, ...

  3. LDEF data: Comparisons with existing models

    Science.gov (United States)

    Coombs, Cassandra R.; Watts, Alan J.; Wagner, John D.; Atkinson, Dale R.

    1993-04-01

    The relationship between the observed cratering impact damage on the Long Duration Exposure Facility (LDEF) versus the existing models for both the natural environment of micrometeoroids and the man-made debris was investigated. Experimental data was provided by several LDEF Principal Investigators, Meteoroid and Debris Special Investigation Group (M&D SIG) members, and by the Kennedy Space Center Analysis Team (KSC A-Team) members. These data were collected from various aluminum materials around the LDEF satellite. A PC (personal computer) computer program, SPENV, was written which incorporates the existing models of the Low Earth Orbit (LEO) environment. This program calculates the expected number of impacts per unit area as functions of altitude, orbital inclination, time in orbit, and direction of the spacecraft surface relative to the velocity vector, for both micrometeoroids and man-made debris. Since both particle models are couched in terms of impact fluxes versus impactor particle size, and much of the LDEF data is in the form of crater production rates, scaling laws have been used to relate the two. Also many hydrodynamic impact computer simulations were conducted, using CTH, of various impact events, that identified certain modes of response, including simple metallic target cratering, perforations and delamination effects of coatings.

  4. Eternally existing self-reproducing inflationary universe

    International Nuclear Information System (INIS)

    Linde, A.D.

    1986-05-01

    It is shown that the large-scale quantum fluctuations of the scalar field φ generated in the chaotic inflation scenario lead to an infinite process of self-reproduction of inflationary mini-universes. A model of eternally existing chaotic inflationary universe is suggested. It is pointed out that whereas the universe locally is very homogeneous as a result of inflation, which occurs at the classical level, the global structure of the universe is determined by quantum effects and is highly non-trivial. The universe consists of exponentially large number of different mini-universes, inside which all possible (metastable) vacuum states and all possible types of compactification are realized. The picture differs crucially from the standard picture of a one-domain universe in a ''true'' vacuum state. Our results may serve as a justification of the anthropic principle in the inflationary cosmology. These results may have important implications for the elementary particle theory as well. Namely, since all possible types of mini-universes, in which inflation may occur, should exist in our universe, there is no need to insist (as it is usually done) that in realistic theories the vacuum state of our type should be the only possible one or the best one. (author)

  5. Existing ingestion guidance: Problems and recommendations

    Energy Technology Data Exchange (ETDEWEB)

    Mooney, Robert R; Ziegler, Gordon L; Peterson, Donald S [Environmental Radiation Section, Division of Radiation Protection, WA (United States)

    1989-09-01

    Washington State has been developing plans and procedures for responding to nuclear accidents since the early 1970s. A key part of this process has been formulating a method for calculating ingestion pathway concentration guides (CGs). Such a method must be both technically sound and easy to use. This process has been slow and frustrating. However, much technical headway has been made in recent years, and hopefully the experience of the State of Washington will provide useful insight to problems with the existing guidance. Several recommendations are offered on ways to deal with these problems. In January 1986, the state held an ingestion pathway exercise which required the determination of allowed concentrations of isotopes for various foods, based upon reactor source term and field data. Objectives of the exercise were not met because of the complexity of the necessary calculations. A major problem was that the allowed concentrations had to be computed for each isotope and each food group, given assumptions on the average diet. To solve problems identified during that exercise, Washington developed, by March 1986, partitioned CGs. These CGs apportioned doses from each food group for an assumed mix of radionuclides expected to result from a reactor accident. This effort was therefore in place just in time for actual use during the Chernobyl fallout episode in May 1986. This technique was refined and described in a later report and presented at the 1987 annual meeting of the Health Physics Society. Realizing the technical weaknesses which still existed and a need to simplify the numbers for decision makers, Washington State has been developing computer methods to quickly calculate, from an accident specific relative mix of isotopes, CGs which allow a single radionuclide concentration for all food groups. This latest approach allows constant CGs for different periods of time following the accident, instead of peak CGs, which are good only for a short time after the

  6. Existing ingestion guidance: Problems and recommendations

    International Nuclear Information System (INIS)

    Mooney, Robert R.; Ziegler, Gordon L.; Peterson, Donald S.

    1989-01-01

    Washington State has been developing plans and procedures for responding to nuclear accidents since the early 1970s. A key part of this process has been formulating a method for calculating ingestion pathway concentration guides (CGs). Such a method must be both technically sound and easy to use. This process has been slow and frustrating. However, much technical headway has been made in recent years, and hopefully the experience of the State of Washington will provide useful insight to problems with the existing guidance. Several recommendations are offered on ways to deal with these problems. In January 1986, the state held an ingestion pathway exercise which required the determination of allowed concentrations of isotopes for various foods, based upon reactor source term and field data. Objectives of the exercise were not met because of the complexity of the necessary calculations. A major problem was that the allowed concentrations had to be computed for each isotope and each food group, given assumptions on the average diet. To solve problems identified during that exercise, Washington developed, by March 1986, partitioned CGs. These CGs apportioned doses from each food group for an assumed mix of radionuclides expected to result from a reactor accident. This effort was therefore in place just in time for actual use during the Chernobyl fallout episode in May 1986. This technique was refined and described in a later report and presented at the 1987 annual meeting of the Health Physics Society. Realizing the technical weaknesses which still existed and a need to simplify the numbers for decision makers, Washington State has been developing computer methods to quickly calculate, from an accident specific relative mix of isotopes, CGs which allow a single radionuclide concentration for all food groups. This latest approach allows constant CGs for different periods of time following the accident, instead of peak CGs, which are good only for a short time after the

  7. Do Bare Rocks Exist on the Moon?

    Science.gov (United States)

    Allen, Carlton; Bandfield, Joshua; Greenhagen, Benjamin; Hayne, Paul; Leader, Frank; Paige, David

    2017-01-01

    Astronaut surface observations and close-up images at the Apollo and Chang'e 1 landing sites confirm that at least some lunar rocks have no discernable dust cover. However, ALSEP (Apollo Lunar Surface Experiments Package) measurements as well as astronaut and LADEE (Lunar Atmosphere and Dust Environment Explorer) orbital observations and laboratory experiments possibly suggest that a fine fraction of dust is levitated and moves across and above the lunar surface. Over millions of years such dust might be expected to coat all exposed rock surfaces. This study uses thermal modeling, combined with Diviner (a Lunar Reconnaissance Orbiter experiment) orbital lunar eclipse temperature data, to further document the existence of bare rocks on the lunar surface.

  8. Integrating existing software toolkits into VO system

    Science.gov (United States)

    Cui, Chenzhou; Zhao, Yong-Heng; Wang, Xiaoqian; Sang, Jian; Luo, Ze

    2004-09-01

    Virtual Observatory (VO) is a collection of interoperating data archives and software tools. Taking advantages of the latest information technologies, it aims to provide a data-intensively online research environment for astronomers all around the world. A large number of high-qualified astronomical software packages and libraries are powerful and easy of use, and have been widely used by astronomers for many years. Integrating those toolkits into the VO system is a necessary and important task for the VO developers. VO architecture greatly depends on Grid and Web services, consequently the general VO integration route is "Java Ready - Grid Ready - VO Ready". In the paper, we discuss the importance of VO integration for existing toolkits and discuss the possible solutions. We introduce two efforts in the field from China-VO project, "gImageMagick" and "Galactic abundance gradients statistical research under grid environment". We also discuss what additional work should be done to convert Grid service to VO service.

  9. Seismic review of existing nuclear power plants

    International Nuclear Information System (INIS)

    Yanev, P.I.; Mayes, R.L.; Jones, L.R.

    1975-01-01

    Because of developments in the fields of earthquake and structural engineering over the last two decades, the codes, standards and design criteria for Nuclear Power Plants and other critical structures have changed substantially. As a result, plants designed only a few years ago do not satisfy the requirements for new plants. Accordingly, the Regulatory Agencies are requiring owners of older Nuclear Power Plants to re-qualify the plants seismically, using codes, standards, analytical techniques and knowledge developed in recent years. Seismic review consists of three major phases: establishing the design and performance criteria, re-qualifying the structures, and re-qualifying the equipment. The authors of the paper have been recently involved in the seismic review of existing nuclear power plants in the United States. This paper is a brief summary of their experiences

  10. Welfare Economics: A Story of Existence

    Directory of Open Access Journals (Sweden)

    Khalid Iqbal

    2017-06-01

    Full Text Available The purpose of this study is to explore that, despite severe challenges, welfare economics still exists. This descriptive study is conducted through some specific time line developments in this field. Economists are divided over the veracity and survival of the welfare economics. Welfare economics emphasizes on the optimum resource and goods allocation with the objective of better living standard, materialistic gains, social welfare and ethical decisions. It origins back to the political economics and utilitarianism. Adam Smith, Irving Fisher and Pareto contributed significantly towards it. During 1930 to 1940, American and British approaches were developed. Many economists tried to explore the relationship between level of income and happiness. Amartya Sen gave the comparative approach and Tinbergen pioneered the theory of equity. Contemporarily the futuristic restoration of welfare economics is on trial and hopes are alive. This study may be useful to understand the transitional and survival process of welfare economics.

  11. Testing Metadata Existence of Web Map Services

    Directory of Open Access Journals (Sweden)

    Jan Růžička

    2011-05-01

    Full Text Available For a general user is quite common to use data sources available on WWW. Almost all GIS software allow to use data sources available via Web Map Service (ISO/OGC standard interface. The opportunity to use different sources and combine them brings a lot of problems that were discussed many times on conferences or journal papers. One of the problem is based on non existence of metadata for published sources. The question was: were the discussions effective? The article is partly based on comparison of situation for metadata between years 2007 and 2010. Second part of the article is focused only on 2010 year situation. The paper is created in a context of research of intelligent map systems, that can be used for an automatic or a semi-automatic map creation or a map evaluation.

  12. On the existence of hot positronium reactions

    International Nuclear Information System (INIS)

    Lazzarini, E.

    1984-01-01

    The existence of hot Ps reactions is nowadays questioned; the controversy arises from the two models (the Ore gap and the spur theories) advanced in order to explain the mechanism of the positronium formation and of its inhibition in liquids by dissolution of certain compounds. The hypothesis of the hot Ps reactions was initially advanced as an additional statement for explaining the inhibition phenomenon within the framework of the Ore gap theory, but it is not considered necessary for the spur theory. The present paper is chiefly intended as a presentation of this particular aspect of Ps chemistry to hot atom chemists unspecialized in the field. The reader is assumed to be familiar with the basic physics and experimental methods used in positronium chemistry. Contents: positrons and positronium formation; inhibition and enhancement of Ps formation in solutions; positronium reactions in gases. (Auth.)

  13. Sustainability in the existing building stock

    DEFF Research Database (Denmark)

    Elle, Morten; Nielsen, Susanne Balslev; Hoffmann, Birgitte

    2005-01-01

    , QRWfacilities management’s most important contribution to sustainable development in the built environment. Space management is an essential tool in facilities management – and it could be considered a powerful tool in sustainable development; remembering that the building not being built is perhaps the most......This paper explores the role of Facilities Management in the relation to sustainable development in the existing building stock. Facilities management is a concept still developing as the management of buildings are becoming more and more professional. Many recognize today that facilities...... management is a concept relevant to others than large companies. Managing the flows of energy and other resources is a part of facilities management, and an increased professionalism could lead to the reduction of the use of energy and water and the generation of waste and wastewater. This is, however...

  14. Compilation of Existing Neutron Screen Technology

    Directory of Open Access Journals (Sweden)

    N. Chrysanthopoulou

    2014-01-01

    Full Text Available The presence of fast neutron spectra in new reactors is expected to induce a strong impact on the contained materials, including structural materials, nuclear fuels, neutron reflecting materials, and tritium breeding materials. Therefore, introduction of these reactors into operation will require extensive testing of their components, which must be performed under neutronic conditions representative of those expected to prevail inside the reactor cores when in operation. Due to limited availability of fast reactors, testing of future reactor materials will mostly take place in water cooled material test reactors (MTRs by tailoring the neutron spectrum via neutron screens. The latter rely on the utilization of materials capable of absorbing neutrons at specific energy. A large but fragmented experience is available on that topic. In this work a comprehensive compilation of the existing neutron screen technology is attempted, focusing on neutron screens developed in order to locally enhance the fast over thermal neutron flux ratio in a reactor core.

  15. [The depression epidemic does not exist].

    Science.gov (United States)

    van der Feltz-Cornelis, Christina M

    2009-01-01

    There has been much discussion in the media about the question of the existence of a depression epidemic. This leads on to the questions of whether the social and economic approaches are adequate, and what the alternatives are. The concept of the disease 'depression' can be defined using a medical model, or from a patient's or a societal perspective. From a medical perspective, indeed a depression epidemic has ensued from the increased prosperity and the associated decompression of the mortality rate. Society responded with preventative measures and policies aimed at improving functioning in the workplace. However, patients with a major depressive disorder (MDD) who are eligible for treatment are often not motivated to take it up, or are undertreated. Research is necessary in order to explore what patients think about the identification and treatment of depression. The confusion regarding the concept of depression found in the media, needs to be cleared.

  16. On the existence of Levi Foliations

    Directory of Open Access Journals (Sweden)

    RENATA N. OSTWALD

    2001-03-01

    Full Text Available Let L be a real 3 dimensional analytic variety. For each regular point p L there exists a unique complex line l p on the space tangent to L at p. When the field of complex line p l p is completely integrable, we say that L is Levi variety. More generally; let L M be a real subvariety in an holomorphic complex variety M. If there exists a real 2 dimensional integrable distribution on L which is invariant by the holomorphic structure J induced by M, we say that L is a Levi variety. We shall prove: Theorem. Let be a Levi foliation and let be the induced holomorphic foliation. Then, admits a Liouvillian first integral. In other words, if is a 3 dimensional analytic foliation such that the induced complex distribution defines an holomorphic foliation ; that is, if is a Levi foliation; then admits a Liouvillian first integral--a function which can be constructed by the composition of rational functions, exponentiation, integration, and algebraic functions (Singer 1992. For example, if f is an holomorphic function and if theta is real a 1-form on ; then the pull-back of theta by f defines a Levi foliation : f*theta = 0 which is tangent to the holomorphic foliation : df = 0. This problem was proposed by D. Cerveau in a meeting (see Fernandez 1997.Seja L Ì uma variedade real de dimensão 3. Para todo ponto regular p Î L existe uma única reta complexa l p no espaço tangente à L em p. Quando o campo de linhas complexas p l p é completamente integrável, dizemos que L é uma variedade de Levi. Mais geralmente, seja L Ì M uma subvariedade real em uma variedade analítica complexa. Se existe uma distribuição real integrável de dimensão 2 em L que é invariante pela estrutura holomorfa J induzida pela variedade complexa M, dizemos que L é uma variedade de Levi. Vamos provar: Teorema. Seja uma folheação de Levi e seja a folheação holomorfa induzida. Então tem integral primeira Liouvilliana. Em outras palavras, se é uma folheação real de

  17. How many N = 4 strings exist?

    International Nuclear Information System (INIS)

    Ketov, S.V.

    1994-09-01

    Possible ways of constructing extended fermionic strings with N=4 world-sheet supersymmetry are reviewed. String theory constraints form, in general, a non-linear quasi(super)conformal algebra, and can have conformal dimensions ≥1. When N=4, the most general N=4 quasi-superconformal algebra to consider for string theory building is D(1, 2; α), whose linearisation is the so-called ''large'' N=4 superconformal algebra. The D(1, 2; α) algebra has su(2)sub(κ + )+su(2)sub(κ - )+u(1) Kac-Moody component, and α=κ - /κ + . We check the Jacobi identities and construct a BRST charge for the D(1, 2; α) algebra. The quantum BRST operator can be made nilpotent only when κ + =κ - =-2. The D(1, 2; 1) algebra is actually isomorphic to the SO(4)-based Bershadsky-Knizhnik non-linear quasi-superconformal algebra. We argue about the existence of a string theory associated with the latter, and propose the (non-covariant) hamiltonian action for this new N=4 string theory. Our results imply the existence of two different N=4 fermionic string theories: the old one based on the ''small'' linear N=4 superconformal algebra and having the total ghost central charge c gh =+12, and the new one with non-linearly realised N=4 supersymmetry, based on the SO(4) quasi-superconformal algebra and having c gh =+6. Both critical string theories have negative ''critical dimensions'' and do not admit unitary matter representations. (orig.)

  18. Evidence of reworked Cretaceous fossils and their bearing on the existence of Tertiary dinosaurs

    Energy Technology Data Exchange (ETDEWEB)

    Eaton, J.G. (Museum of Northern Arizona, Flagstaff (USA)); Kirkland, J.I. (Univ. of Nebraska, Lincoln (USA)); Doi, K. (Univ. of Colorado, Boulder (USA))

    1989-06-01

    The Paleocene Shotgun fauna of Wyoming includes marine sharks as well as mammals. It has been suggested that the sharks were introduced from the Cannonball Sea. It is more likely that these sharks were reworked from a Cretaceous rock sequence that included both marine and terrestrial deposits as there is a mixture of marine and freshwater taxa. These taxa have not been recorded elsewhere after the Cretaceous and are not known from the Cannonball Formation. Early Eocene localities at Raven Ridge, Utah, similarly contain teeth of Cretaceous marine and freshwater fish, dinosaurs, and Eocene mammals. The Cretaceous teeth are well preserved, variably abraded, and serve to cast doubts on criteria recently used to claim that dinosaur teeth recovered from the Paleocene of Montana are not reworked. Another Eocene locality in the San Juan Basin has produced an Eocene mammalian fauna with diverse Cretaceous marine sharks. Neither the nature of preservation nor the degree of abrasion could be used to distinguish reworked from contemporaneous material. The mixed environments represented by the fish taxa and recognition of the extensive pre-Tertiary extinction of both marine and freshwater fish were employed to recognize reworked specimens.

  19. When guilt evokes self-punishment: evidence for the existence of a Dobby Effect.

    Science.gov (United States)

    Nelissen, Rob M A; Zeelenberg, Marcel

    2009-02-01

    Feelings of guilt may be resolved in various ways. The scientific literature has mainly highlighted beneficial interpersonal consequences of guilt, showing repeatedly that guilt motivates compensatory pro-social behavior to repair social bonds. The authors reveal that when opportunities for compensation are not present, guilt may evoke self-punishment. Self-punishment was demonstrated through self-denied pleasure in a scenario study, and by self-enforced penalties in an experimental study. The authors call this tendency for self-punishment the Dobby Effect, and discuss it as an explanation for the widely held conviction that atonement absolves sins, its contribution to some types of psychopathology, as well as its possible functional relevance. (c) 2009 APA, all rights reserved

  20. Does Far Transfer Exist? Negative Evidence From Chess, Music, and Working Memory Training.

    Science.gov (United States)

    Sala, Giovanni; Gobet, Fernand

    2017-12-01

    Chess masters and expert musicians appear to be, on average, more intelligent than the general population. Some researchers have thus claimed that playing chess or learning music enhances children's cognitive abilities and academic attainment. We here present two meta-analyses assessing the effect of chess and music instruction on children's cognitive and academic skills. A third meta-analysis evaluated the effects of working memory training-a cognitive skill correlated with music and chess expertise-on the same variables. The results show small to moderate effects. However, the effect sizes are inversely related to the quality of the experimental design (e.g., presence of active control groups). This pattern of results casts serious doubts on the effectiveness of chess, music, and working memory training. We discuss the theoretical and practical implications of these findings; extend the debate to other types of training such as spatial training, brain training, and video games; and conclude that far transfer of learning rarely occurs.

  1. Evidence Refuting the Existence of Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA)

    DEFF Research Database (Denmark)

    Ameratunga, Rohan; Gillis, David; Gold, Michael

    2017-01-01

    Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) was described in 2011. Over time the condition and its triggers have broadened to include several autoimmune disorders, the macrophagic myofasciitis syndrome, the Gulf war syndrome, the sick building syndrome, siliconosis...

  2. Existing evidence on the influence of prebiotic intake on the risk of colorectal cancer

    Directory of Open Access Journals (Sweden)

    Mireia Hidalgo-Garcia

    2013-03-01

    Full Text Available Colorectal cancer is one of the most common cancers worldwide. Among the risk of developing colorectal cancer and the intestinal microbiota there is a complex relationship that can be modified by diet. The effect of prebiotics on the composition and colonic microbiota activity can produce beneficial changes in the altered flora of pacients with colon cancer. Of all the prebiotic inulin HP and sinergil (30% oligofructose and 70% inulin are supposed to be the ones that keep a closer relationship with the tumor. This phenomenon could be explained by the long chain fructans. The animal studies observed that administration of prebiotics reduces the number and multiplicity of aberrant crypt foci, reduce the number and lifetime of the tumors, inhibits their growth and potentiates the effect of different chemotherapeutic drugs. The results obtained in rodents that are intended to simulate genetic predisposition are not homogeneous. Some human studies, mostly healthy, observed changes in the composition of the microbiota, in the bile acid profile and the short chain fatty acids, but the results differ among studies and no conclusive results are obtained.

  3. On the Existence of Semantic Working Memory: Evidence for Direct Semantic Maintenance

    Science.gov (United States)

    Shivde, Geeta; Anderson, Michael C.

    2011-01-01

    Despite widespread acknowledgment of the importance of online semantic maintenance, there has been astonishingly little work that clearly establishes this construct. We review the extant work relevant to short-term retention of meaning and show that, although consistent with semantic working memory, most data can be accommodated in other ways.…

  4. Afrikaans as a Split-IP language: evidence for the existence of ...

    African Journals Online (AJOL)

    Simone

    "I asked why Helgi often read books." *Ég spurði af ... that the label "Agr" is not a key component of BandT's (1998) analysis, and that within an. Agr-less ..... Conradie conducted studies on the second language acquisition of. Afrikaans ... prohibited in Afrikaans, as Donaldson claims, then native speakers of Afrikaans should.

  5. Evidence for the existence of sulfur-doped fullerenes from elucidation of their photophysical properties

    Energy Technology Data Exchange (ETDEWEB)

    Glenis, S.; Cooke, S.; Chen, X.; Labes, M.M. [Temple Univ., Philadelphia, PA (United States)

    1996-01-01

    Cage carbon atoms of fullerenes were substituted by sulfur in sulfur-doped fullerenes synthesized by the authors. The synthesis method was based on the arc evaporation of graphite in the presence of thiophene or 3-methylthiophene. Structural characterization was accomplished through mass spectrometry and fluorescence spectroscopy and crude purification regimens using column chromatography were established. 24 refs., 4 figs., 1 tab.

  6. Did the contagion effect exist? Evidence from Abu Dhabi, Jordan and America

    OpenAIRE

    Ho, Liang-Chun; Huang, Chia-Hsing

    2014-01-01

    This article aims to test the contagion effect between the stock markets of Abu Dhabi, Jordan and America. The Lagrange multiplier (LM) principle for causality in variance test is used in this study. Four American stock indexes, Dow Jones Industrial Average, NASDAQ Composite, RUSSELL 2000, and PHLX Semiconductor Sector Index, are in this study. The testing results of the four major American stock price indexes and the Jordan stock index (Amman) are significant. The testing results of the f...

  7. New Evidence of the Existence of Associative Elements of Water (Clusters)

    OpenAIRE

    Ignat Ignatov; Oleg Mosin

    2016-01-01

    In this review it is reported about new data on the structure of water cyclic associates (clusters) with general formula (Н2О)n and their charged ionic clusters [(Н2О)n]+ and [(Н2О)n]- by means of computer modelling and spectroscopy methods as 1Н-NMR, IR-spectroscopy, DNES, EXAFS-spectroscopy, X-Ray and neurons diffraction. The computer calculation of polyhedral nanoclusters (Н2О)n, where n = 3–20 are carried out. Based on this data the main structural mathematical models describing water str...

  8. Molecular evidence for the existence of cryptic species assemblages of several myxosporeans (Myxozoa)

    Czech Academy of Sciences Publication Activity Database

    Bartošová, Pavla; Fiala, Ivan

    2011-01-01

    Roč. 108, č. 3 (2011), s. 573-583 ISSN 0932-0113 R&D Project s: GA AV ČR KJB600960701; GA ČR GD524/03/H133; GA MŠk LC522 Institutional research plan: CEZ:AV0Z60220518 Keywords : SUBUNIT RIBOSOMAL-RNA * RUTILUS-RUTILUS LINNAEUS * LIFE -CYCLE * PHYLOGENY Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.149, year: 2011

  9. Evidence for the existence of water:ethanol clusters from o-Ps yields

    International Nuclear Information System (INIS)

    Smith, F.A.; Beling, C.D.

    1982-01-01

    Lifetime measurements have been made in mixtures of water and ethanol at 293 K. Fluctuations are observed in both o-Ps yield and decay rate as a function of water concentration with local maxima occurring at molecular ratios (EtOH:H 2 O) of 4:1 and 1:1. The results are interpreted in terms of cluster formation at these concentrations. (Auth.)

  10. On Empirical Evidence for the Existence of Rules Governing Speech-Using Behavior.

    Science.gov (United States)

    Sanders, Robert E.; Schneider, Michael

    Departing from Baconian science which focuses on explanation of the occurrence of events, Chomsky's linguistics involves a different orientation--namely the explanation of form to account for linguistic behavior. The "knowledge" upon which linguistic judgements are based involves the premise of innate mechanisms. The assumption that speakers and…

  11. 'Cultures do not exist' : Exploding self-evidences in the investigation of interculturality

    NARCIS (Netherlands)

    Binsbergen, van W.M.J.

    2003-01-01

    This volume brings together fifteen essays investigating aspects of interculturality. Published between 1969 and 2002, the essays operate at the borderline between anthropology and intercultural philosophy. Ethnographic data are derived from field research carried out in Tunisia, Zambia and

  12. Spontaneous chromosome aberrations in cancer cells. Evidence of existence of hidden genetic lesions in genetic structures

    International Nuclear Information System (INIS)

    Poryadkova-Luchnik, N.A.; Kuz'mina, E.G.

    1996-01-01

    Chromosome aberrations spontaneously observed in cancer cells were quantitively studied under the effect of non-mutagenic (suboptimal temperature, low content of propilgallate and caffeine) and mutagenic (ionizing radiation) factors. Human larynx cancer cells during several years or gamma-irradiation were used to carry out experiments. The experiments linked with cloning of the initial population and investigation into chromosome aberrations in 22 clones demonstrated persuasively the occurrence of latent genetic lesions in cancer cells

  13. Energy consumptions in existing buildings; Les consommations d'energie des batiments existants

    Energy Technology Data Exchange (ETDEWEB)

    Nuss, St. [Ecole Nationale Superieure des Arts et Industries de Strasbourg, 78 - Saint-Remy-Les-Chevreuse (France)]|[Costic, 78 - Sainte Remy les Chevreuses (France)

    2002-05-01

    This document presents a sectoral analysis of the energy consumptions in existing French buildings: 1) - residential sector: social buildings, private dwellings; 2) - tertiary sector: office buildings, hotels, commercial buildings, school buildings, hospitals; 3) - industry; 4) - general status. (J.S.)

  14. Evidence gap maps -- a tool for promoting evidence-informed policy and prioritizing future research

    OpenAIRE

    Snilstveit, Birte; Vojtkova, Martina; Bhavsar, Ami; Gaarder, Marie

    2013-01-01

    Evidence-gap maps present a new addition to the tools available to support evidence-informed policy making. Evidence-gap maps are thematic evidence collections covering a range of issues such as maternal health, HIV/AIDS, and agriculture. They present a visual overview of existing systematic reviews or impact evaluations in a sector or subsector, schematically representing the types of int...

  15. Evidence-based dentistry.

    Science.gov (United States)

    Chambers, David W

    2010-01-01

    Both panegyric and criticism of evidence-based dentistry tend to be clumsy because the concept is poorly defined. This analysis identifies several contributions to the profession that have been made under the EBD banner. Although the concept of clinicians integrating clinical epidemiology, the wisdom of their practices, and patients' values is powerful, its implementation has been distorted by a too heavy emphasis of computerized searches for research findings that meet the standards of academics. Although EBD advocates enjoy sharing anecdotal accounts of mistakes others have made, faulting others is not proof that one's own position is correct. There is no systematic, high-quality evidence that EBD is effective. The metaphor of a three-legged stool (evidence, experience, values, and integration) is used as an organizing principle. "Best evidence" has become a preoccupation among EBD enthusiasts. That overlong but thinly developed leg of the stool is critiqued from the perspectives of the criteria for evidence, the difference between internal and external validity, the relationship between evidence and decision making, the ambiguous meaning of "best," and the role of reasonable doubt. The strongest leg of the stool is clinical experience. Although bias exists in all observations (including searches for evidence), there are simple procedures that can be employed in practice to increase useful and objective evidence there, and there are dangers in delegating policy regarding allowable treatments to external groups. Patient and practitioner values are the shortest leg of the stool. As they are so little recognized, their integration in EBD is problematic and ethical tensions exist where paternalism privileges science over patient's self-determined best interests. Four potential approaches to integration are suggested, recognizing that there is virtually no literature on how the "seat" of the three-legged stool works or should work. It is likely that most dentists

  16. Effectiveness of Existing International Nuclear Liability Regime

    International Nuclear Information System (INIS)

    Al-Doais, Salwa; Kessel, Daivd

    2015-01-01

    The first convention was the Paris Convention on Third Party Liability in the Field of Nuclear Energy (the Paris Convention) had been adopted on 29 July 1960 under the auspices of the OECD, and entered into force on 1 April 1968. In 1963,the Brussels Convention - supplementary to the Paris Convention- was adopted in to provide additional funds to compensate damage as a result of a nuclear incident where Paris Convention funds proved to be insufficient. The IAEA's first convention was the Vienna Convention on Civil Liability for Nuclear Damage (the Vienna Convention) which adopted on 21 May 1963,and entered into force in 1977. Both the Paris Convention and the Vienna Convention laid down very similar nuclear liability rules based on the same general principles. The broad principles in these conventions can be summarized as follows: 1- The no-fault liability principle (strict liability) 2- Liability is channeled exclusively to the operator of the nuclear installation (legal channeling) 3- Only courts of the state in which the nuclear accident occurs would have jurisdiction (exclusive jurisdiction) 4- Limitation of the amount of liability and the time frame for claiming damages (limited liability) 5- The operator is required to have adequate insurance or financial guarantees to the extent of its liability amount (liability must be financially secured). 6- Liability is limited in time. Compensation rights are extinguished after specific time. 7- Non-discrimination of victims on the grounds of nationality, domicile or residence. Nuclear liability conventions objective is to provide adequate compensation payments to victims of a nuclear accident. Procedures for receiving these compensation are controlled by some rules such as exclusive jurisdiction, that rule need a further amendment to ensure the effectiveness of the exiting nuclear liability regime . Membership of the Conventions is a critical issue, because the existence of the conventions without being party to

  17. Existing facilities and past practices: Lessons learned

    International Nuclear Information System (INIS)

    Huizenga, D.; Tonkay, D.W.; Owens, K.

    2000-01-01

    Article 12 of the Joint Convention on the Safety of Spent Fuel Management and on the Safety of Radioactive Waste Management (Joint Convention) requires parties to the Joint Convention to review the safety of existing radioactive waste management facilities 'to ensure that, if necessary, all reasonably practicable improvements are made to upgrade the safety of such a facility'. Also required is a review of the results of past practices to determine 'whether any intervention is needed for reasons of radiation protection' and to consider whether the benefits of the intervention or remediation are sufficient, with regard to the costs and the impact on workers, the public and the environment. This paper discusses the experience of the United States Department of Energy in terms of the lessons learned from operating radioactive waste management facilities and from undertaking intervention or remedial action, and from decision making in an international context. Overarching safety principles are discussed, including integrating safety into all work practices and minimizing the generation of waste. Safety review lessons learned with existing facilities are discussed with respect to: applying new requirements to old facilities, taking a life-cycle perspective of waste management, improving high level waste facility management, and blending current and past practices with respect to the process used to arrive at decisions for intervention. Special emphasis is placed on the need to provide for early and substantive input from the involved regulatory agencies, Native American tribes, and those citizens and groups with an interest in the decisions. Examples of intervention decisions are discussed, including examples taken from uranium mill tailings operations, from cleanup of a former uranium processing plant site, from evaluation of pre-1970 buried 'transuranic waste' sites, and from decommissioning or closure of high level waste storage tanks. The paper concludes that on the

  18. Measuring Input Thresholds on an Existing Board

    Science.gov (United States)

    Kuperman, Igor; Gutrich, Daniel G.; Berkun, Andrew C.

    2011-01-01

    A critical PECL (positive emitter-coupled logic) interface to Xilinx interface needed to be changed on an existing flight board. The new Xilinx input interface used a CMOS (complementary metal-oxide semiconductor) type of input, and the driver could meet its thresholds typically, but not in worst-case, according to the data sheet. The previous interface had been based on comparison with an external reference, but the CMOS input is based on comparison with an internal divider from the power supply. A way to measure what the exact input threshold was for this device for 64 inputs on a flight board was needed. The measurement technique allowed an accurate measurement of the voltage required to switch a Xilinx input from high to low for each of the 64 lines, while only probing two of them. Directly driving an external voltage was considered too risky, and tests done on any other unit could not be used to qualify the flight board. The two lines directly probed gave an absolute voltage threshold calibration, while data collected on the remaining 62 lines without probing gave relative measurements that could be used to identify any outliers. The PECL interface was forced to a long-period square wave by driving a saturated square wave into the ADC (analog to digital converter). The active pull-down circuit was turned off, causing each line to rise rapidly and fall slowly according to the input s weak pull-down circuitry. The fall time shows up as a change in the pulse width of the signal ready by the Xilinx. This change in pulse width is a function of capacitance, pulldown current, and input threshold. Capacitance was known from the different trace lengths, plus a gate input capacitance, which is the same for all inputs. The pull-down current is the same for all inputs including the two that are probed directly. The data was combined, and the Excel solver tool was used to find input thresholds for the 62 lines. This was repeated over different supply voltages and

  19. Effectiveness of Existing International Nuclear Liability Regime

    Energy Technology Data Exchange (ETDEWEB)

    Al-Doais, Salwa; Kessel, Daivd [KEPCO International Nuclear Graduate School, Daejeon (Korea, Republic of)

    2015-10-15

    The first convention was the Paris Convention on Third Party Liability in the Field of Nuclear Energy (the Paris Convention) had been adopted on 29 July 1960 under the auspices of the OECD, and entered into force on 1 April 1968. In 1963,the Brussels Convention - supplementary to the Paris Convention- was adopted in to provide additional funds to compensate damage as a result of a nuclear incident where Paris Convention funds proved to be insufficient. The IAEA's first convention was the Vienna Convention on Civil Liability for Nuclear Damage (the Vienna Convention) which adopted on 21 May 1963,and entered into force in 1977. Both the Paris Convention and the Vienna Convention laid down very similar nuclear liability rules based on the same general principles. The broad principles in these conventions can be summarized as follows: 1- The no-fault liability principle (strict liability) 2- Liability is channeled exclusively to the operator of the nuclear installation (legal channeling) 3- Only courts of the state in which the nuclear accident occurs would have jurisdiction (exclusive jurisdiction) 4- Limitation of the amount of liability and the time frame for claiming damages (limited liability) 5- The operator is required to have adequate insurance or financial guarantees to the extent of its liability amount (liability must be financially secured). 6- Liability is limited in time. Compensation rights are extinguished after specific time. 7- Non-discrimination of victims on the grounds of nationality, domicile or residence. Nuclear liability conventions objective is to provide adequate compensation payments to victims of a nuclear accident. Procedures for receiving these compensation are controlled by some rules such as exclusive jurisdiction, that rule need a further amendment to ensure the effectiveness of the exiting nuclear liability regime . Membership of the Conventions is a critical issue, because the existence of the conventions without being party to

  20. [Summary of the existing knowledge about electronic cigarettes].

    Science.gov (United States)

    Cselkó, Zsuzsa; Pénzes, Melinda

    2016-06-19

    The decreasing proportion of smokers due to smoking restrictions have led producers to invent and disseminate electronic cigarettes (e-cigarettes) worldwide as a new form of nicotine enjoyment. This review summarizes the existing knowledge about e-cigarettes based on publications of PubMed, and on reviews and research data published by national and international scientific institutions. Present knowledge about the composition of e-cigarettes confirms that they are harmful products since their vapor is equally detrimental to the health of users and bystanders. Their benefits in smoking cessation still have not been justified by adequate scientific evidence, however, it has been proven that e-cigarettes uphold nicotine addiction and may increase the risk of starting conventional cigarette use by youth. In order to ensure the results of tobacco control policy and to assist smoking cessation, the same regulations are to be applied to e-cigarettes as to conventional tobacco products.

  1. Existing reflection seismic data re-processing

    International Nuclear Information System (INIS)

    Higashinaka, Motonori; Sano, Yukiko; Kozawa, Takeshi

    2005-08-01

    This document is to report the results of existing seismic data re-processing around Horonobe town, Hokkaido, Japan, which is a part of the Horonobe Underground Research Project. The main purpose of this re-processing is to recognize the subsurface structure of Omagari Fault and fold system around Omagari Fault. The seismic lines for re-processing are TYHR-A3 line and SHRB-2 line, which JAPEX surveyed in 1975. Applying weathering static correction using refraction analysis and noise suppression procedure, we have much enhanced seismic profile. Following information was obtained from seismic re-processing results. TYHR-A3 line: There are strong reflections, dipping to the west. These reflections are corresponding western limb of anticline to the west side of Omagari Fault. SHRB-2 line: There are strong reflections, dipping to the west, at CDP 60-140, while there are reflections, dipping to the east, to the east side of CDP 140. These reflections correspond to the western limb and the eastern limb of the anticline, which is parallel to Omagari FAULT. This seismic re-processing provides some useful information to know the geological structure around Omagari Fault. (author)

  2. On the Existence of Evolutionary Learning Equilibriums

    Directory of Open Access Journals (Sweden)

    Masudul Alam Choudhury

    2011-12-01

    Full Text Available The usual kinds of Fixed-Point Theorems formalized on the existence of competitive equilibrium that explain much of economic theory at the core of economics can operate only on bounded and closed sets with convex mappings. But these conditions are hardly true of the real world of economic and financial complexities and perturbations. The category of learning sets explained by continuous fields of interactive, integrative and evolutionary behaviour caused by dynamic preferences at the individual and institutional and social levels cannot maintain the assumption of closed, bounded and convex sets. Thus learning sets and multi-system inter-temporal relations explained by pervasive complementarities and  participation between variables and entities, and evolution by learning, have evolutionary equilibriums. Such a study requires a new methodological approach. This paper formalizes such a methodology for evolutionary equilibriums in learning spaces. It briefly points out the universality of learning equilibriums in all mathematical structures. For a particular case though, the inter-systemic interdependence between sustainable development and ethics and economics in the specific understanding of learning domain is pointed out.

  3. Does the chromatic Mach bands effect exist?

    Science.gov (United States)

    Tsofe, Avital; Spitzer, Hedva; Einav, Shmuel

    2009-06-30

    The achromatic Mach bands effect is a well-known visual illusion, discovered over a hundred years ago. This effect has been investigated thoroughly, mainly for its brightness aspect. The existence of Chromatic Mach bands, however, has been disputed. In recent years it has been reported that Chromatic Mach bands are not perceived under controlled iso-luminance conditions. However, here we show that a variety of Chromatic Mach bands, consisting of chromatic and achromatic regions, separated by a saturation ramp, can be clearly perceived under iso-luminance and iso-brightness conditions. In this study, observers' eye movements were recorded under iso-brightness conditions. Several observers were tested for their ability to perceive the Chromatic Mach bands effect and its magnitude, across different cardinal and non-cardinal Chromatic Mach bands stimuli. A computational model of color adaptation, which predicted color induction and color constancy, successfully predicts this variation of Chromatic Mach bands. This has been tested by measuring the distance of the data points from the "achromatic point" and by calculating the shift of the data points from predicted complementary lines. The results suggest that the Chromatic Mach bands effect is a specific chromatic induction effect.

  4. Evaluation and modification of existing CETP.

    Science.gov (United States)

    Sharma, Bhavisha; Shah, A R

    2013-07-01

    For the development of small and medium scale industries in various Gujarat industrial development corporation (GIDC) areas and in clusters of industrial areas, the common effluent treatment plant (CETP) has always been found advantageous in view of cost of treatment, operation and maintenance and disposal of residues being produced. In small scale industrial units due to market requirement, product changes and quantity enhancement are taking place. Due to such changes, the effluent characteristics are continuously changing which affects performance of CETP. Hence it has been found necessary to study continuously the performance, evaluation and modification in the working of the CETP. This paper contains a case study of one of the existing CETP near Baroda which is facing the problem of disposal of treated effluent in which the important parameters like COD, BOD, Suspended Solid, NH3-N and oil and grease were analyzed. Based on the characterization of wastewater, the various treatability studies were carried out on CETP wastewater. To comply with disposal standard prescribed by Effluent Channel Project Ltd.(ECPL)* and Gujarat Pollution Control Board (GPCB) for discharge of industrial effluent into channel, various treatments in form of ammonia stripping, coagulation and flocculation, biological treatment, filtration and chlorination are suggested.

  5. On the existence of tropical anvil clouds

    Science.gov (United States)

    Seeley, J.; Jeevanjee, N.; Langhans, W.; Romps, D.

    2017-12-01

    In the deep tropics, extensive anvil clouds produce a peak in cloud cover below the tropopause. The dominant paradigm for cloud cover attributes this anvil peak to a layer of enhanced mass convergence in the clear-sky upper-troposphere, which is presumed to force frequent detrainment of convective anvils. However, cloud cover also depends on the lifetime of cloudy air after it detrains, which raises the possibility that anvil clouds may be the signature of slow cloud decay rather than enhanced detrainment. Here we measure the cloud decay timescale in cloud-resolving simulations, and find that cloudy updrafts that detrain in the upper troposphere take much longer to dissipate than their shallower counterparts. We show that cloud lifetimes are long in the upper troposphere because the saturation specific humidity becomes orders of magnitude smaller than the typical condensed water loading of cloudy updrafts. This causes evaporative cloud decay to act extremely slowly, thereby prolonging cloud lifetimes in the upper troposphere. As a consequence, extensive anvil clouds still occur in a convecting atmosphere that is forced to have no preferential clear-sky convergence layer. On the other hand, when cloud lifetimes are fixed at a characteristic lower-tropospheric value, extensive anvil clouds do not form. Our results support a revised understanding of tropical anvil clouds, which attributes their existence to the microphysics of slow cloud decay rather than a peak in clear-sky convergence.

  6. Bibliography - Existing Guidance for External Hazard Modelling

    International Nuclear Information System (INIS)

    Decker, Kurt

    2015-01-01

    The bibliography of deliverable D21.1 includes existing international and national guidance documents and standards on external hazard assessment together with a selection of recent scientific papers, which are regarded to provide useful information on the state of the art of external event modelling. The literature database is subdivided into International Standards, National Standards, and Science Papers. The deliverable is treated as a 'living document' which is regularly updated as necessary during the lifetime of ASAMPSA-E. The current content of the database is about 140 papers. Most of the articles are available as full-text versions in PDF format. The deliverable is available as an EndNote X4 database and as text files. The database includes the following information: Reference, Key words, Abstract (if available), PDF file of the original paper (if available), Notes (comments by the ASAMPSA-E consortium if available) The database is stored at the ASAMPSA-E FTP server hosted by IRSN. PDF files of original papers are accessible through the EndNote software

  7. Economic evaluations of personalized medicine: existing challenges and current developments

    Directory of Open Access Journals (Sweden)

    Shabaruddin FH

    2015-06-01

    Full Text Available Fatiha H Shabaruddin,1 Nigel D Fleeman,2 Katherine Payne3 1Department of Pharmacy, University of Malaya, Kuala Lumpur, Malaysia; 2Liverpool Reviews and Implementation Group (LRiG, University of Liverpool, Liverpool, UK; 3Institute of Population Health, The University of Manchester, Manchester, UK Abstract: Personalized medicine, with the aim of safely, effectively, and cost-effectively targeting treatment to a prespecified patient population, has always been a long-time goal within health care. It is often argued that personalizing treatment will inevitably improve clinical outcomes for patients and help achieve more effective use of health care resources. Demand is increasing for demonstrable evidence of clinical and cost-effectiveness to support the use of personalized medicine in health care. This paper begins with an overview of the existing challenges in conducting economic evaluations of genetics- and genomics-targeted technologies, as an example of personalized medicine. Our paper illustrates the complexity of the challenges faced by these technologies by highlighting the variations in the issues faced by diagnostic tests for somatic variations, generally referring to genetic variation in a tumor, and germline variations, generally referring to inherited genetic variation in enzymes involved in drug metabolic pathways. These tests are typically aimed at stratifying patient populations into subgroups on the basis of clinical effectiveness (response or safety (avoidance of adverse events. The paper summarizes the data requirements for economic evaluations of genetics and genomics-based technologies while outlining that the main challenges relating to data requirements revolve around the availability and quality of existing data. We conclude by discussing current developments aimed to address the challenges of assessing the cost-effectiveness of genetics and genomics-based technologies, which revolve around two central issues that are

  8. Reproducibility in Psychological Science: When Do Psychological Phenomena Exist?

    Directory of Open Access Journals (Sweden)

    Seppo E. Iso-Ahola

    2017-06-01

    Full Text Available Scientific evidence has recently been used to assert that certain psychological phenomena do not exist. Such claims, however, cannot be made because (1 scientific method itself is seriously limited (i.e., it can never prove a negative; (2 non-existence of phenomena would require a complete absence of both logical (theoretical and empirical support; even if empirical support is weak, logical and theoretical support can be strong; (3 statistical data are only one piece of evidence and cannot be used to reduce psychological phenomena to statistical phenomena; and (4 psychological phenomena vary across time, situations and persons. The human mind is unreproducible from one situation to another. Psychological phenomena are not particles that can decisively be tested and discovered. Therefore, a declaration that a phenomenon is not real is not only theoretically and empirically unjustified but runs counter to the propositional and provisional nature of scientific knowledge. There are only “temporary winners” and no “final truths” in scientific knowledge. Psychology is a science of subtleties in human affect, cognition and behavior. Its phenomena fluctuate with conditions and may sometimes be difficult to detect and reproduce empirically. When strictly applied, reproducibility is an overstated and even questionable concept in psychological science. Furthermore, statistical measures (e.g., effect size are poor indicators of the theoretical importance and relevance of phenomena (cf. “deliberate practice” vs. “talent” in expert performance, not to mention whether phenomena are real or unreal. To better understand psychological phenomena, their theoretical and empirical properties should be examined via multiple parameters and criteria. Ten such parameters are suggested.

  9. Reproducibility in Psychological Science: When Do Psychological Phenomena Exist?

    Science.gov (United States)

    Iso-Ahola, Seppo E.

    2017-01-01

    Scientific evidence has recently been used to assert that certain psychological phenomena do not exist. Such claims, however, cannot be made because (1) scientific method itself is seriously limited (i.e., it can never prove a negative); (2) non-existence of phenomena would require a complete absence of both logical (theoretical) and empirical support; even if empirical support is weak, logical and theoretical support can be strong; (3) statistical data are only one piece of evidence and cannot be used to reduce psychological phenomena to statistical phenomena; and (4) psychological phenomena vary across time, situations and persons. The human mind is unreproducible from one situation to another. Psychological phenomena are not particles that can decisively be tested and discovered. Therefore, a declaration that a phenomenon is not real is not only theoretically and empirically unjustified but runs counter to the propositional and provisional nature of scientific knowledge. There are only “temporary winners” and no “final truths” in scientific knowledge. Psychology is a science of subtleties in human affect, cognition and behavior. Its phenomena fluctuate with conditions and may sometimes be difficult to detect and reproduce empirically. When strictly applied, reproducibility is an overstated and even questionable concept in psychological science. Furthermore, statistical measures (e.g., effect size) are poor indicators of the theoretical importance and relevance of phenomena (cf. “deliberate practice” vs. “talent” in expert performance), not to mention whether phenomena are real or unreal. To better understand psychological phenomena, their theoretical and empirical properties should be examined via multiple parameters and criteria. Ten such parameters are suggested. PMID:28626435

  10. Interim Storage of Plutonium in Existing Facilities

    International Nuclear Information System (INIS)

    Woodsmall, T.D.

    1999-01-01

    'In this era of nuclear weapons disarmament and nonproliferation treaties, among many problems being faced by the Department of Energy is the safe disposal of plutonium. There is a large stockpile of plutonium at the Rocky Flats Environmental Technology Center and it remains politically and environmentally strategic to relocate the inventory closer to a processing facility. Savannah River Site has been chosen as the final storage location, and the Actinide Packaging and Storage Facility (APSF) is currently under construction for this purpose. With the ability of APSF to receive Rocky Flats material an estimated ten years away, DOE has decided to use the existing reactor building in K-Area of SRS as temporary storage to accelerate the removal of plutonium from Rocky Flats. There are enormous cost savings to the government that serve as incentive to start this removal as soon as possible, and the KAMS project is scheduled to receive the first shipment of plutonium in January 2000. The reactor building in K-Area was chosen for its hardened structure and upgraded seismic qualification, both resulting from an effort to restart the reactor in 1991. The KAMS project has faced unique challenges from Authorization Basis and Safety Analysis perspectives. Although modifying a reactor building from a production facility to a storage shelter is not technically difficult, the nature of plutonium has caused design and safety analysis engineers to make certain that the design of systems, structures and components included will protect the public, SRS workers, and the environment. A basic overview of the KAMS project follows. Plutonium will be measured and loaded into DOT Type-B shipping packages at Rocky Flats. The packages are 35-gallon stainless steel drums with multiple internal containment boundaries. DOE transportation vehicles will be used to ship the drums to the KAMS facility at SRS. They will then be unloaded, stacked and stored in specific locations throughout the

  11. Seismic evaluation of existing nuclear facilities. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    Programmes for re-evaluation and upgrading of safety of existing nuclear facilities are presently under way in a number of countries around the world. An important component of these programmes is the re-evaluation of the seismic safety through definition of new seismic parameters at the site and evaluation of seismic capacity of structures, equipment and distribution systems following updated information and criteria. The Seminar is intended to provide a forum for the exchange of information and discussion of the state-of-the-art on seismic safety of nuclear facilities in operation or under construction. Both analytical and experimental techniques for the evaluation of seismic capacity of structures, equipment and distribution systems are discussed. Full scale and field tests of structures and components using shaking tables, mechanical exciters, explosive and shock tests, and ambient vibrations are included in the seminar programme with emphasis on recent case histories. Presentations at the Seminar also include analytical techniques for the determination of dynamic properties of soil-structure systems from experiments as well as calibration of numerical models. Methods and criteria for seismic margin assessment based on experience data obtained from the behaviour of structures and components in real earthquakes are discussed. Guidelines for defining technical requirements for capacity re-evaluation (i.e. acceptable behaviour limits and design and implementation of structure and components upgrades are also presented and discussed. The following topics were covered during 7 sessions: earthquake experience and seismic re-evaluation; country experience in seismic re-evaluation programme; generic WWER studies; analytical methods for seismic capacity re-evaluation; experimental methods for seismic capacity re-evaluation; case studies.

  12. Does Glocal Political Power Already Exist?

    Directory of Open Access Journals (Sweden)

    Lorenzo Ornaghi

    2017-05-01

    Full Text Available Large periods of history are usually characterized by equally important moments of change in scientific knowledge and, in particular, in the understanding of political power. We still need to study in depth whether the former provokes (almost of out necessity the latter, or whether they are “great” because they are favored by the innovation of the paradigms of knowledge. The passage from medieval universalism to the particularism of the modern age represents an extremely interesting analogy when compared to the transformations that are now underway. The example of John of Salisbury’s Policratus, the starting point of this article, is illuminating in our comprehension of the relevance of the interweaving between the persistence of the ancient forms of recognition of power and the search for new forms. The existence of glocal realities is already a fact. Even if it is relatively easy to recognize these realities (a business, a university, a humanitarian association, not a few of the same “parts” which constitute the traditional organization of the State, it is more difficult to define the specific characteristics of the power at their disposal. Moving from the widening gap between “actual” power and “potential” power, the article examines the motives for which the classical definitions of power are always becoming more insufficient in understanding the role now emerging from glocal realities. And, in particular, by looking at how the “command-obedience” relationship is changing also as a consequence of communication networks and information technology, the article analyzes that specific “contamination” within global elements and local elements, which seems to be the main base of glocal political power.

  13. Virtual existence in contemporary Serbian novel

    Directory of Open Access Journals (Sweden)

    Gordić-Petković Vladislava S.

    2017-01-01

    Full Text Available The paper sets out to explore the perspectives and strategies of virtual existence in contemporary Serbian novel in order to illustrate radical changes in the concept of reality and writers' concern with the fidelity to experience. A new surge of the so-called digital realism emerges simultaneously with the increase of awareness that the line between our digital selves and our real-world selves has become blurred and difficult to explain, while new technologies are required to go beyond what our human senses can encompass and deliver. The fictional realism of the digital age will also commit itself to young or middle-aged individuals that passionately attempt to define their aims and objectives so that they could fit into a newly constructed and acquired concept of reality. This is the case with the protagonists in the novels by Ivančica Đerić, Tamara Jecić and Aleksandar Ilić, all of them questioning both their offline and online identities. Their everyday life in a postmillennial world includes many intersecting empirical and virtual realities: love, career and sex take place in a dimension which ignores geography and physical distance and ultimately alters the concepts of time and space, as well the concepts of privacy and intimacy. The paper intends to examine the ways new digital technologies contribute to representations of reality in the novels of both accomplished and aspiring authors whose novels deal with ways of life amid social networks. The novels we analyzed show that the distinction between the virtual and the real world narrows, as the narratives range from intimate confession in letters and journals to tweets, notes and statuses, introducing verbal and structural experimental practices which involve shifting points of view.

  14. Thallium exists in opioid poisoned patients.

    Science.gov (United States)

    Ghaderi, Amir; Vahdati-Mashhadian, Naser; Oghabian, Zohreh; Moradi, Valiallah; Afshari, Reza; Mehrpour, Omid

    2015-08-01

    Thallium (Tl) is a toxic heavy metal that exists in nature. Tl poisoning (thallotoxicosis) may occur in opioid addicts. This study was designed to evaluate the frequency and level of urinary Tl in opioid abusers. In addition, clinical findings were evaluated. A total of 150 subjects were examined. Cases with a history of at least 3 years of abuse were admitted in the Imam Reza Hospital as the case group; 50 non-opioid abusers from the target population were included as the control group. Twenty-four hour urinary qualitative and quantitative Tl analyses were performed on both groups. Out of the 150 subjects, 128 (85 %) were negative for qualitative urinary Tl, followed by 5 % (trace), 7 % (1+), 2 % (2+), and 1 % (3+). Mean (standard error (SE), Min-Max) quantitative urinary Tl level was 14 μg/L (3.5 μg/L, 0-346 μg/L). Mean urinary Tl level in the case group was 21 μg/L (5 μg/L, 0-346 μg/L) and that in the controls was 1 μg/L (0.14 μg/L, 0-26 μg/L), which were significantly different (P = 0.001). The most frequent clinical findings were ataxia (86 %), sweating (81 %), and constipation (54 %). In all cases (n = 150), the mean (SE) value for cases with positive qualitative urinary Tl was 26.8 μg/L (0.9 μg/L) and that in the negative cases was 2.3 μg/L (0.2 μg/L), which were significantly different (P = 0.002). This study showed that long-term opioid abuse may lead to Tl exposure. In opioid abusers with the clinical manifestation of thallotoxicosis, urinary Tl should be determined.

  15. Seismic evaluation of existing nuclear facilities. Proceedings

    International Nuclear Information System (INIS)

    1995-01-01

    Programmes for re-evaluation and upgrading of safety of existing nuclear facilities are presently under way in a number of countries around the world. An important component of these programmes is the re-evaluation of the seismic safety through definition of new seismic parameters at the site and evaluation of seismic capacity of structures, equipment and distribution systems following updated information and criteria. The Seminar is intended to provide a forum for the exchange of information and discussion of the state-of-the-art on seismic safety of nuclear facilities in operation or under construction. Both analytical and experimental techniques for the evaluation of seismic capacity of structures, equipment and distribution systems are discussed. Full scale and field tests of structures and components using shaking tables, mechanical exciters, explosive and shock tests, and ambient vibrations are included in the seminar programme with emphasis on recent case histories. Presentations at the Seminar also include analytical techniques for the determination of dynamic properties of soil-structure systems from experiments as well as calibration of numerical models. Methods and criteria for seismic margin assessment based on experience data obtained from the behaviour of structures and components in real earthquakes are discussed. Guidelines for defining technical requirements for capacity re-evaluation (i.e. acceptable behaviour limits and design and implementation of structure and components upgrades are also presented and discussed. The following topics were covered during 7 sessions: earthquake experience and seismic re-evaluation; country experience in seismic re-evaluation programme; generic WWER studies; analytical methods for seismic capacity re-evaluation; experimental methods for seismic capacity re-evaluation; case studies

  16. Electric foot shock stress adaptation: Does it exist or not?

    Science.gov (United States)

    Bali, Anjana; Jaggi, Amteshwar Singh

    2015-06-01

    Stress adaptation is a protective phenomenon against repeated stress exposure and is characterized by a decreased responsiveness to a repeated stress stimulus. The adaptation is associated with a complex cascade of events, including the changes in behavior, neurotransmitter and gene expression levels. The non-adaptation or maladaptation to stress may underlie the affective disorders, such as anxiety, depression and post-traumatic stress disorder (PTSD). Electric foot shock is a complex stressor, which includes both physical and emotional components. Unlike immobilization, restraint and cold immersion stress, the phenomenon of stress adaptation is not very well defined in response to electric foot shock. A number of preclinical studies have reported the development of adaptation to electric foot shock stress. However, evidence also reveals the non-adaptive behavior in response to foot shocks. The distinct adaptive/non-adaptive responses may be possibly influenced by the type, intensity, and duration of the stress. The present review discusses the existence or non-existence of adaptation to electric foot shock stress along with possible mechanism. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. Does GaH5 exist?

    Science.gov (United States)

    Speakman, Lucas D.; Turney, Justin M.; Schaefer, Henry F.

    2005-11-01

    The existence or nonexistence of GaH5 has been widely discussed [N. M. Mitzel, Angew. Chem. Int. Ed. 42, 3856 (2003)]. Seven possible structures for gallium pentahydride have been systematically investigated using ab initio electronic structure theory. Structures and vibrational frequencies have been determined employing self-consistent field, coupled cluster including all single and double excitations (CCSD), and CCSD with perturbative triples levels of theory, with at least three correlation-consistent polarized-valence-(cc-pVXZ and aug-cc-pVXZ) type basis sets. The X˜A'1 state for GaH5 is predicted to be weakly bound complex 1 between gallane and molecular hydrogen, with Cs symmetry. The dissociation energy corresponding to GaH5→GaH3+H2 is predicted to be De=2.05kcalmol-1. The H-H stretching fundamental is predicted to be v =4060cm-1, compared to the tentatively assigned experimental feature of Wang and Andrews [J. Phys. Chem. A 107, 11371 (2003)] at 4087cm-1. A second Cs structure 2 with nearly equal energy is predicted to be a transition state, corresponding to a 90° rotation of the H2 bond. Thus the rotation of the hydrogen molecule is essentially free. However, hydrogen scrambling through the C2v structure 3 seems unlikely, as the activation barrier for scrambling is at least 30kcalmol-1 higher in energy than that for the dissociation of GaH5 to GaH3 and H2. Two additional structures consisting of GaH3 with a dihydrogen bond perpendicular to gallane (C3v structure 4) and an in-plane dihydrogen bond [Cs(III) structure 5] were also examined. A C3v symmetry second-order saddle point has nearly the same energy as the GaH3+H2 dissociation limit, while the Cs(III) structure 5 is a transition structure to the C3v structure. The C4v structure 6 and the D3h structure 7 are much higher in energy than GaH3+H2 by 88 and 103kcalmol-1, respectively.

  18. A precariedade humana e a existência estilizada Human precariousness and stylized existence

    Directory of Open Access Journals (Sweden)

    Rita Paiva

    2013-04-01

    Full Text Available Este artigo tematiza o desamparo vivenciado pela consciência ante a ausência de bases sólidas para seus anseios de felicidade e para suas representações simbólicas. Com esse propósito, toma como objeto de reflexão um dos ensaios filosóficos de Albert Camus, O mito de Sísifo, equacionando a possibilidade de uma ética que estilize a vida, sem que se minimize a dolorosa precariedade da existência humana. Posteriormente, em diálogo com alguns textos de M. Foucault, a reflexão procura estabelecer os vínculos possíveis entre a ética camusiana e a ética como uma estética da existência, tal como pensada entre os gregos antigos.This article discusses the helplessness experienced by the consciousness vis-à-vis the absence of solid bases for its longings for happiness and for its symbolic representations. For this purpose, the object of reflection of the article is one of Albert Camus' philosophical essays, The Myth of Sisyphus, and we inquire into the possibility of an ethics that stylizes life without minimizing the painful precariousness of human existence. Making reference to certain texts by Foucault, we attempt to establish possible connections between Camus' ethics and an ethics of the aesthetics of existence as found in the thinkers of ancient Greece.

  19. Existence and non-existence of solutions for a singular problem with variable potentials

    Directory of Open Access Journals (Sweden)

    Kamel Saoudi

    2017-11-01

    Full Text Available The purpose of this article is to prove some existence and nonexistence theorems for the inhomogeneous singular Dirichlet problem $$ - \\Delta_p u = \\frac{\\lambda k(x}{u^\\delta}\\pm h(x u^q. $$ For proving our results we use the sub and super solution method, and monotonicity arguments.

  20. Evidence on Inclusion

    DEFF Research Database (Denmark)

    Dyssegaard, Camilla Brørup; Larsen, Michael Søgaard

    The purpose of this publication is to examine existing research on inclusion to identify strategies of inclusion that have generated positive effects. To do so it is necessary to understand the effect of the applied strategies. One approach, which is being discussed, is to use evidence to determine...... which methods have proven more effective than others. The desire to gain insight into research on inclusion forms the basis of the current systematic review. The task was to determine which strategies primary research has found to be most effective for inclusion purposes. We have solved this task...... by addressing the existing research with the following question: What is the effect of including children with special needs in mainstream teaching in basic school, and which of the applied educational methods have proved to have a positive effect?...

  1. Black Hole Caught Zapping Galaxy into Existence?

    Science.gov (United States)

    2009-11-01

    , construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role in promoting and organising cooperation in astronomical research. ESO operates three unique world-class observing sites in Chile: La Silla, Paranal and Chajnantor. At Paranal, ESO operates the Very Large Telescope, the world's most advanced visible-light astronomical observatory. ESO is the European partner of a revolutionary astronomical telescope ALMA, the largest astronomical project in existence. ESO is currently planning a 42-metre European Extremely Large optical/near-infrared Telescope, the E-ELT, which will become "the world's biggest eye on the sky".

  2. Existence and non-existence of solutions for a p(x-biharmonic problem

    Directory of Open Access Journals (Sweden)

    Ghasem A. Afrouzi

    2015-06-01

    Full Text Available In this article, we study the following problem with Navier boundary conditions $$\\displaylines{ \\Delta (|\\Delta u|^{p(x-2}\\Delta u+|u|^{p(x-2}u =\\lambda |u|^{q(x-2}u +\\mu|u|^{\\gamma(x-2}u\\quad \\text{in } \\Omega,\\cr u=\\Delta u=0 \\quad \\text{on } \\partial\\Omega. }$$ where $\\Omega$ is a bounded domain in $\\mathbb{R}^{N}$ with smooth boundary $\\partial \\Omega$, $N\\geq1$. $p(x,q(x$ and $\\gamma(x$ are continuous functions on $\\overline{\\Omega}$, $\\lambda$ and $\\mu$ are parameters. Using variational methods, we establish some existence and non-existence results of solutions for this problem.

  3. Effect of auditing: Evidence from variability of stock returns and trading volume

    Directory of Open Access Journals (Sweden)

    Charles J.P. Chen

    2014-12-01

    Full Text Available Although the benefits of auditing are uncontroversial in developed markets, there is scant evidence about its effect in emerging economies. Auditing derives its value by increasing the credibility of financial statements, which in turn increases investors’ reliance on them in developed markets. Financial statement information is common to all investors and therefore increased reliance on it should reduce divergence in investors’ assessment of firm value. We examine the effect of interim auditing on inter-investor divergence with a large sample of listed Chinese firms and find that it decreases more for firms whose reports are audited compared to non-audited firms. This finding suggests that investors rely more on audited financial information. Results of this study are robust to variations in event window length and specification of empirical measures.

  4. 40 CFR 427.34 - Pretreatment standards for existing sources.

    Science.gov (United States)

    2010-07-01

    ...) EFFLUENT GUIDELINES AND STANDARDS ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Paper (Starch Binder) Subcategory § 427.34 Pretreatment standards for existing sources. Any existing source subject to...

  5. 40 CFR 427.44 - Pretreatment standards for existing sources.

    Science.gov (United States)

    2010-07-01

    ...) EFFLUENT GUIDELINES AND STANDARDS ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Paper (Elastomeric Binder) Subcategory § 427.44 Pretreatment standards for existing sources. Any existing source subject to...

  6. 40 CFR 417.84 - Pretreatment standards for existing sources.

    Science.gov (United States)

    2010-07-01

    ...) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Liquid Soaps Subcategory § 417.84 Pretreatment standards for existing sources. Any existing source...

  7. The direction of causality between exports and firm performance: microeconomic evidence from Croatia using the matching approach

    Directory of Open Access Journals (Sweden)

    Miljana Valdec

    2015-03-01

    Full Text Available This paper contributes to the literature by using propensity score matching to test for causal effects of starting to export on firm performance in Croatian manufacturing firm-level data. The results confirm that exporters have characteristics superior to those of non-exporters. In the main sample specification there is pervasive evidence of self-selection into export markets, meaning that firms are successful years before they become exporters. Using multiple firm performance indicators, panel and cross section data models together with various sample specifications there is scant evidence on learning-by-exporting which holds true only in a few cases. On the other hand, higher sales growth is found to be a more conclusive distinguishing characteristic of new exporters. As in similar studies, we find that a part of the results depends on the number of export starters in the estimation sample.

  8. A Classroom Labor Market Game Illustrating the Existence, and Implications of, Statistical Discrimination

    Science.gov (United States)

    Henrickson, Kevin E.

    2014-01-01

    Many undergraduate students report a lack of concern about facing labor market discrimination throughout their careers. However, there is ample evidence that discrimination based on race, gender, and age still persists within the labor market. The author outlines a classroom experiment demonstrating the existence of discrimination, even when the…

  9. A computational approach to finding novel targets for existing drugs.

    Directory of Open Access Journals (Sweden)

    Yvonne Y Li

    2011-09-01

    Full Text Available Repositioning existing drugs for new therapeutic uses is an efficient approach to drug discovery. We have developed a computational drug repositioning pipeline to perform large-scale molecular docking of small molecule drugs against protein drug targets, in order to map the drug-target interaction space and find novel interactions. Our method emphasizes removing false positive interaction predictions using criteria from known interaction docking, consensus scoring, and specificity. In all, our database contains 252 human protein drug targets that we classify as reliable-for-docking as well as 4621 approved and experimental small molecule drugs from DrugBank. These were cross-docked, then filtered through stringent scoring criteria to select top drug-target interactions. In particular, we used MAPK14 and the kinase inhibitor BIM-8 as examples where our stringent thresholds enriched the predicted drug-target interactions with known interactions up to 20 times compared to standard score thresholds. We validated nilotinib as a potent MAPK14 inhibitor in vitro (IC50 40 nM, suggesting a potential use for this drug in treating inflammatory diseases. The published literature indicated experimental evidence for 31 of the top predicted interactions, highlighting the promising nature of our approach. Novel interactions discovered may lead to the drug being repositioned as a therapeutic treatment for its off-target's associated disease, added insight into the drug's mechanism of action, and added insight into the drug's side effects.

  10. Evidence-based surgery

    Directory of Open Access Journals (Sweden)

    Miran Rems

    2007-04-01

    Full Text Available Background: Surgery is setting a new ground by the reign of evidence that was brought up by the Evidence Based Medicine (EBM. While experiences and opinion of an expert count the least by the principles of EBM, randomized controlled trials (RCT and other comparative studies have gained their importance. Recommendations that were included in guidelines represent a demanding shift in surgeon’s professional thinking. Their thinking and classical education have not yet been completely based on the results of such studies and are still very very much master-pupil centred. Assessment of someone’s own experiences is threatened by objectivity as negative experiences get recorded in deeper memory. Randomized studies and meta-analyses do appear also in surgery. However, they demand an extra knowledge about critical assessment.Conclusions: Setting a patient to the foreground brings a surgeon’s decision to the field of EBM. The process has already begun and cannot be avoided. Decision hierarchy moves from the experience field to the evidence territory but to a lesser extent when compared to the rest of medicine. There exist objective restrictions with approving a new paradigm. However, these should not stop the process of EBM implementation. Finally, there is an ethic issue to be considered. Too slow activities in research, education and critical assessment can bring the surgeon to the position when a well-informed patient loses his/her trust.

  11. Improved measurements of scant hydrogen peroxide enable experiments that define its threshold of toxicity for Escherichia coli.

    Science.gov (United States)

    Li, Xin; Imlay, James A

    2018-03-14

    Escherichia coli is a model organism that has been exploited to reveal key details of hydrogen peroxide stress: the biomolecules that H 2 O 2 most rapidly damages and the defensive tactics that organisms use to fend it off. Much less clear is the amount of exogenous H 2 O 2 that is sufficient to injure the bacterium and/or to trigger its stress response. To fill this gap, we need to study the behavior of cells when they are exposed to defined amounts of H 2 O 2 on an hours-long time scale. Such experiments are difficult because bacteria rapidly consume H 2 O 2 that is added to test cultures. Further, lab media itself can generate H 2 O 2 , and media components interfere with the quantification of H 2 O 2 levels. In this study we describe mechanisms by which media components interfere with H 2 O 2 determinations, and we identify simple ways to minimize and correct for this interference. Using these techniques, it was shown that standard media generate so much H 2 O 2 that most intracellular H 2 O 2 derives from the medium rather than from endogenous metabolism. Indeed, bacteria spread on plates must induce their stress response or else perish. Finally, two straightforward methods were used to sustain low-micromolar steady-state concentrations of H 2 O 2 . In this way we determined that > 2 μM extracellular H 2 O 2 is sufficient to trigger the intracellular OxyR stress response, and > 5 μM begins to impair cell growth in a minimal medium. These concentrations are orders of magnitude lower than the doses that have typically been used in lab experiments. The new approaches should enable workers to study how various organisms cope with natural levels of H 2 O 2 stress. Copyright © 2018 Elsevier Inc. All rights reserved.

  12. Integration of existing systematic reviews into new reviews: identification of guidance needs

    Science.gov (United States)

    2014-01-01

    Background An exponential increase in the number of systematic reviews published, and constrained resources for new reviews, means that there is an urgent need for guidance on explicitly and transparently integrating existing reviews into new systematic reviews. The objectives of this paper are: 1) to identify areas where existing guidance may be adopted or adapted, and 2) to suggest areas for future guidance development. Methods We searched documents and websites from healthcare focused systematic review organizations to identify and, where available, to summarize relevant guidance on the use of existing systematic reviews. We conducted informational interviews with members of Evidence-based Practice Centers (EPCs) to gather experiences in integrating existing systematic reviews, including common issues and challenges, as well as potential solutions. Results There was consensus among systematic review organizations and the EPCs about some aspects of incorporating existing systematic reviews into new reviews. Current guidance may be used in assessing the relevance of prior reviews and in scanning references of prior reviews to identify studies for a new review. However, areas of challenge remain. Areas in need of guidance include how to synthesize, grade the strength of, and present bodies of evidence composed of primary studies and existing systematic reviews. For instance, empiric evidence is needed regarding how to quality check data abstraction and when and how to use study-level risk of bias assessments from prior reviews. Conclusions There remain areas of uncertainty for how to integrate existing systematic reviews into new reviews. Methods research and consensus processes among systematic review organizations are needed to develop guidance to address these challenges. PMID:24956937

  13. Habituation in non-neural organisms: evidence from slime moulds.

    Science.gov (United States)

    Boisseau, Romain P; Vogel, David; Dussutour, Audrey

    2016-04-27

    Learning, defined as a change in behaviour evoked by experience, has hitherto been investigated almost exclusively in multicellular neural organisms. Evidence for learning in non-neural multicellular organisms is scant, and only a few unequivocal reports of learning have been described in single-celled organisms. Here we demonstrate habituation, an unmistakable form of learning, in the non-neural organism Physarum polycephalum In our experiment, using chemotaxis as the behavioural output and quinine or caffeine as the stimulus, we showed that P. polycephalum learnt to ignore quinine or caffeine when the stimuli were repeated, but responded again when the stimulus was withheld for a certain time. Our results meet the principle criteria that have been used to demonstrate habituation: responsiveness decline and spontaneous recovery. To distinguish habituation from sensory adaptation or motor fatigue, we also show stimulus specificity. Our results point to the diversity of organisms lacking neurons, which likely display a hitherto unrecognized capacity for learning, and suggest that slime moulds may be an ideal model system in which to investigate fundamental mechanisms underlying learning processes. Besides, documenting learning in non-neural organisms such as slime moulds is centrally important to a comprehensive, phylogenetic understanding of when and where in the tree of life the earliest manifestations of learning evolved. © 2016 The Author(s).

  14. Electrophysiological evidence for effects of color knowledge in object recognition.

    Science.gov (United States)

    Lu, Aitao; Xu, Guiping; Jin, Hua; Mo, Lei; Zhang, Jijia; Zhang, John X

    2010-01-29

    Knowledge about the typical colors associated with familiar everyday objects (i.e., strawberries are red) is well-known to be represented in the conceptual semantic system. Evidence that such knowledge may also play a role in early perceptual processes for object recognition is scant. In the present ERP study, participants viewed a list of object pictures and detected infrequent stimulus repetitions. Results show that shortly after stimulus onset, ERP components indexing early perceptual processes, including N1, P2, and N2, differentiated between objects in their appropriate or congruent color from these objects in an inappropriate or incongruent color. Such congruence effect also occurred in N3 associated with semantic processing of pictures but not in N4 for domain-general semantic processing. Our results demonstrate a clear effect of color knowledge in early object recognition stages and support the following proposal-color as a surface property is stored in a multiple-memory system where pre-semantic perceptual and semantic conceptual representations interact during object recognition. (c) 2009 Elsevier Ireland Ltd. All rights reserved.

  15. Psiquiatria baseada em evidências Evidence-based psychiatry

    Directory of Open Access Journals (Sweden)

    Maurício S de Lima

    2000-09-01

    Full Text Available Em psiquiatria, observa-se grande variabilidade de práticas clínicas, muitas vezes desnecessária. Essas variações podem estar relacionadas à ausência de evidência científica confiável ou ao desconhecimento das evidências de boa qualidade disponíveis. A medicina baseada em evidências (MBE é uma combinação de estratégias que busca assegurar que o cuidado individual do paciente seja baseado na melhor informação disponível, a qual deve ser incorporada à prática clínica. Neste artigo, conceitos de MBE são discutidos com relação a aspectos e desafios no tratamento de pacientes com distimia, bulimia nervosa e esquizofrenia. A partir de resultados de três revisões sistemáticas recentemente publicadas, conclui-se que a prática de psiquiatria baseada em evidências acrescenta qualidade à prática psiquiátrica tradicional.The unnecessary variability often seen in the clinical practice can be related to both the absence of reliable evidence and unawareness of the existence of good quality evidence. Evidence-Based Medicine (EBM is a set of linked strategies designed to assist clinicians in keeping themselves up-to-date with the best available evidence. Such evidence must be incorporated into the clinical practice. EBM concepts are discussed here through common aspects and challenges doctors face when treating patients with dysthymia, bulimia nervosa, and schizophrenia. In the light of some results from three systematic reviews it is concluded that Evidence-Based Psychiatry strategies, rather than replacing the traditional ones, may be a valuable tool to improving quality in a good clinical practice.

  16. EXISTENCE OF POSITIVE SOLUTIONS FOR AN ELASTIC CURVED BEAM EQUATION

    Directory of Open Access Journals (Sweden)

    Béla Kovacs

    2017-06-01

    Full Text Available This paper investigates the existence of positive solutions for a sixth-order differential equations. By using the Leggett-Williams fixed point theorem we give some new existence results.

  17. Integrated testing strategies for toxicity employing new and existing technologies.

    Science.gov (United States)

    Combes, Robert D; Balls, Michael

    2011-07-01

    We have developed individual, integrated testing strategies (ITS) for predicting the toxicity of general chemicals, cosmetics, pharmaceuticals, inhaled chemicals, and nanoparticles. These ITS are based on published schemes developed previously for the risk assessment of chemicals to fulfil the requirements of REACH, which have been updated to take account of the latest developments in advanced in chemico modelling and in vitro technologies. In addition, we propose an ITS for neurotoxicity, based on the same principles, for incorporation in the other ITS. The technologies are deployed in a step-wise manner, as a basis for decision-tree approaches, incorporating weight-of-evidence stages. This means that testing can be stopped at the point where a risk assessment and/or classification can be performed, with labelling in accordance with the requirements of the regulatory authority concerned, rather than following a checklist approach to hazard identification. In addition, the strategies are intelligent, in that they are based on the fundamental premise that there is no hazard in the absence of exposure - which is why pharmacokinetic modelling plays a key role in each ITS. The new technologies include the use of complex, three-dimensional human cell tissue culture systems with in vivo-like structural, physiological and biochemical features, as well as dosing conditions. In this way, problems of inter-species extrapolation and in vitro/in vivo extrapolation are minimised. This is reflected in the ITS placing more emphasis on the use of volunteers at the whole organism testing stage, rather than on existing animal testing, which is the current situation. 2011 FRAME.

  18. 40 CFR 406.34 - Pretreatment standards for existing sources.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Pretreatment standards for existing sources. 406.34 Section 406.34 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... § 406.34 Pretreatment standards for existing sources. Any existing source subject to this subpart that...

  19. 40 CFR 406.44 - Pretreatment standards for existing sources.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Pretreatment standards for existing sources. 406.44 Section 406.44 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... § 406.44 Pretreatment standards for existing sources. Any existing source subject to this subpart that...

  20. Existence of pareto equilibria for multiobjective games without compactness

    OpenAIRE

    Shiraishi, Yuya; Kuroiwa, Daishi

    2013-01-01

    In this paper, we investigate the existence of Pareto and weak Pareto equilibria for multiobjective games without compactness. By employing an existence theorem of Pareto equilibria due to Yu and Yuan([10]), several existence theorems of Pareto and weak Pareto equilibria for the multiobjective games are established in a similar way to Flores-B´azan.

  1. International symposium on seismic evaluation of existing nuclear facilities

    Energy Technology Data Exchange (ETDEWEB)

    Orbovic, N.; Bouchon, M. [Institut de Radioprotection et de Surete Nucleaire, IRSN, 92 - Fontenay aux Roses (France); Vendel, J.; Gelain, T. [IRSN/DPEA/SERAC, 91 - Gif sur Yvette (France)

    2003-10-01

    Below are summarized the works of Mrs N. Orbovic and M. Bouchon; B. Stojadinovic, N. Orbovic, M.Bouchon and J.T. Wiley; M. Bouchon, N. Orbovic and B. Foure; T. Gelain, F. Gensdarmes, R. Sestier-Carlin, J. Vendel and M. Bouchon dealing respectively with: 1) seismic assessment of existing nuclear facility: a case study position of the IRSN 2) static and dynamic evaluation of an existing nuclear facility reinforced concrete frame structure 3) experimental study of cracking of low-rise reinforced concrete shear walls 4) aeraulics study of crack networks on low-rise reinforced concrete walls subject to static cycling loading. The summaries are followed: 1) The Institute for Radioprotection and Nuclear Safety (IRSN) has the task of evaluating the seismic safety of existing building inventory in French nuclear facilities. Some of the existing structures are reinforced concrete frame buildings with masonry or reinforced concrete in-fill walls built during the 1960's, 70's and 80's following different building codes and seismic input data applicable at the time of construction. The studied building is a laboratory that was built in 1962. The building is composed of three different and independent blocks. The structure is a reinforced concrete frame with masonry in-fills and few stiff concrete elements. Moreover, the building contains an independent massive concrete cell. Structurally, the building has a number of irregularities. From the detailing standpoint, well known deficiencies of low-ductile reinforced concrete structures are evident especially, a lack of transverse reinforcement in the structural joints of the frame. A number of sensitivity studies were conducted using 2D and 3D linear models to evaluate seismic demand. Ambient vibration and regional earthquake records were used to check the soil nature and the existence or not of a possible site effect around the installation as well as to characterize the dynamic behavior of the building. 3D models

  2. International symposium on seismic evaluation of existing nuclear facilities

    International Nuclear Information System (INIS)

    Orbovic, N.; Bouchon, M.; Vendel, J.; Gelain, T.

    2003-10-01

    Below are summarized the works of Mrs N. Orbovic and M. Bouchon; B. Stojadinovic, N. Orbovic, M.Bouchon and J.T. Wiley; M. Bouchon, N. Orbovic and B. Foure; T. Gelain, F. Gensdarmes, R. Sestier-Carlin, J. Vendel and M. Bouchon dealing respectively with: 1) seismic assessment of existing nuclear facility: a case study position of the IRSN 2) static and dynamic evaluation of an existing nuclear facility reinforced concrete frame structure 3) experimental study of cracking of low-rise reinforced concrete shear walls 4) aeraulics study of crack networks on low-rise reinforced concrete walls subject to static cycling loading. The summaries are followed: 1) The Institute for Radioprotection and Nuclear Safety (IRSN) has the task of evaluating the seismic safety of existing building inventory in French nuclear facilities. Some of the existing structures are reinforced concrete frame buildings with masonry or reinforced concrete in-fill walls built during the 1960's, 70's and 80's following different building codes and seismic input data applicable at the time of construction. The studied building is a laboratory that was built in 1962. The building is composed of three different and independent blocks. The structure is a reinforced concrete frame with masonry in-fills and few stiff concrete elements. Moreover, the building contains an independent massive concrete cell. Structurally, the building has a number of irregularities. From the detailing standpoint, well known deficiencies of low-ductile reinforced concrete structures are evident especially, a lack of transverse reinforcement in the structural joints of the frame. A number of sensitivity studies were conducted using 2D and 3D linear models to evaluate seismic demand. Ambient vibration and regional earthquake records were used to check the soil nature and the existence or not of a possible site effect around the installation as well as to characterize the dynamic behavior of the building. 3D models revealed a

  3. Nature, nurture, and capital punishment: How evidence of a genetic-environment interaction, future dangerousness, and deliberation affect sentencing decisions.

    Science.gov (United States)

    Gordon, Natalie; Greene, Edie

    2018-01-01

    Research has shown that the low-activity MAOA genotype in conjunction with a history of childhood maltreatment increases the likelihood of violent behaviors. This genetic-environment (G × E) interaction has been introduced as mitigation during the sentencing phase of capital trials, yet there is scant data on its effectiveness. This study addressed that issue. In a factorial design that varied mitigating evidence offered by the defense [environmental (i.e., childhood maltreatment), genetic, G × E, or none] and the likelihood of the defendant's future dangerousness (low or high), 600 mock jurors read sentencing phase evidence in a capital murder trial, rendered individual verdicts, and half deliberated as members of a jury to decide a sentence of death or life imprisonment. The G × E evidence had little mitigating effect on sentencing preferences: participants who received the G × E evidence were no less likely to sentence the defendant to death than those who received evidence of childhood maltreatment or a control group that received neither genetic nor maltreatment evidence. Participants with evidence of a G × E interaction were more likely to sentence the defendant to death when there was a high risk of future dangerousness than when there was a low risk. Sentencing preferences were more lenient after deliberation than before. We discuss limitations and future directions. Copyright © 2017 John Wiley & Sons, Ltd.

  4. SMART literature review report on existing practice in measuring success factors in second chance education

    DEFF Research Database (Denmark)

    Jensen, Ulla Højmark

    2015-01-01

    criteria, indicators and benchmarks that measures developments of learners, impacts of informal and non-formal learning methods and evidences success factors of second chance education. The aim of the project is to build an evidence base of outcomes and impacts of second chance education and to enhance......, and the Commission cannot be held responsible for any use which may be made of the information contained therein. This literature review aims at developing an insight of the existing practice of measuring and evidencing success factors in second chance education. In the following, we will highlight examples of good...

  5. FCJ-201 Visual Evidence from Above: Assessing the Value of Earth Observation Satellites for Supporting Human Rights

    Directory of Open Access Journals (Sweden)

    Tanya Notley

    2016-03-01

    Full Text Available Public access to data collected by remote sensing Earth Observation Satellites has, until recently, been very limited. Now, citizens and rights advocacy groups are increasingly utilising satellite-collected images to interrogate justice issues; to document, prevent and verify rights abuses; and to imagine and propose social change. Yet while other communication technologies have received substantial critical analysis regarding their value as tools of social justice, activism and resistance, satellites have received comparatively scant attention. This article examines the uses of satellite-collected images in human rights contexts including the opportunities, challenges and risks they pose. We conclude this examination by arguing that if satellites are to be used effectively to collect evidence from above by rights advocates, greater attention to and capacity for ensuring accountability from below is required.

  6. Evidence & Gap Maps: A tool for promoting evidence informed policy and strategic research agendas.

    Science.gov (United States)

    Snilstveit, Birte; Vojtkova, Martina; Bhavsar, Ami; Stevenson, Jennifer; Gaarder, Marie

    2016-11-01

    A range of organizations are engaged in the production of evidence on the effects of health, social, and economic development programs on human welfare outcomes. However, evidence is often scattered around different databases, web sites, and the gray literature and is often presented in inaccessible formats. Lack of overview of the evidence in a specific field can be a barrier to the use of existing research and prevent efficient use of limited resources for new research. Evidence & Gap Maps (EGMs) aim to address these issues and complement existing synthesis and mapping approaches. EGMs are a new addition to the tools available to support evidence-informed policymaking. To provide an accessible resource for researchers, commissioners, and decision makers, EGMs provide thematic collections of evidence structured around a framework which schematically represents the types of interventions and outcomes of relevance to a particular sector. By mapping the existing evidence using this framework, EGMs provide a visual overview of what we know and do not know about the effects of different programs. They make existing evidence available, and by providing links to user-friendly summaries of relevant studies, EGMs can facilitate the use of existing evidence for decision making. They identify key "gaps" where little or no evidence from impact evaluations and systematic reviews is available and can be a valuable resource to inform a strategic approach to building the evidence base in a particular sector. The article will introduce readers to the concept and methods of EGMs and present a demonstration of the EGM tool using existing examples. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Twelve recommendations for integrating existing systematic reviews into new reviews: EPC guidance.

    Science.gov (United States)

    Robinson, Karen A; Chou, Roger; Berkman, Nancy D; Newberry, Sydne J; Fu, Rongwei; Hartling, Lisa; Dryden, Donna; Butler, Mary; Foisy, Michelle; Anderson, Johanna; Motu'apuaka, Makalapua; Relevo, Rose; Guise, Jeanne-Marie; Chang, Stephanie

    2016-02-01

    As time and cost constraints in the conduct of systematic reviews increase, the need to consider the use of existing systematic reviews also increases. We developed guidance on the integration of systematic reviews into new reviews. A workgroup of methodologists from Evidence-based Practice Centers developed consensus-based recommendations. Discussions were informed by a literature scan and by interviews with organizations that conduct systematic reviews. Twelve recommendations were developed addressing selecting reviews, assessing risk of bias, qualitative and quantitative synthesis, and summarizing and assessing body of evidence. We provide preliminary guidance for an efficient and unbiased approach to integrating existing systematic reviews with primary studies in a new review. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. The evidence for efficacy of osteoporosis treatment in men with primary osteoporosis: a systematic review and meta-analysis of antiresorptive and anabolic treatment in men

    DEFF Research Database (Denmark)

    Schwarz, Peter; Jorgensen, Niklas Rye; Mosekilde, Leif

    2011-01-01

    of antiresorptive treatment were included. All studies showed an increase in BMD, but there was only a nonsignificant trend in the reduction of clinical fractures. Three BMD studies of anabolic treatment with teriparatide were also included. These showed a significant mean increase in spine BMD and for vertebral...... treatment in men. Methods. This study was a systematic review of the published literature on the clinical efficacy of medical osteoporosis therapy in the reduction of fracture risk in men (age > 50 years). Studies included were randomised, placebo-controlled trials of men. Results. Five BMD studies...... fractures a non-significant trend towards a reduction was seen. Conclusion. The evidence of medical osteoporosis treatment in men is scant and inconclusive due to the lack of prospective RCT studies with fracture prevention as primary end point. So far, all evidence is based on BMD increases in small RCT...

  9. Method and refrigerants for replacing existing refrigerants in centrifugal compressors

    International Nuclear Information System (INIS)

    Kopko, W.L.

    1991-01-01

    This patent describes a method for replacing an existing refrigerant in a centrifugal compressor. It comprises selecting a desired impeller Mach number for the centrifugal compressor; selecting a base refrigerant constituent; combining at least one additive refrigerant constituent with the base refrigerant constituent to form a replacement refrigerant having at least one physical or chemical property different from the existing refrigerant and substantially providing the desired impeller Mach number in the centrifugal compressor; and replacing the existing refrigerant with the replacement refrigerant

  10. Magnetic nesting and co-existence of ferromagnetism and superconductivity

    International Nuclear Information System (INIS)

    Elesin, V.F.; Kapaev, V.V.; Kopaev, Yu.V.

    2004-01-01

    In the case of providing for the magnetic nesting conditions of the electron spin dispersion law the co-existence of ferromagnetism and superconductivity is possible by any high magnetization. The co-existence of ferromagnetism and superconductivity in the layered cuprate compounds of the RuSr 2 GdCu 2 O 8 -type is explained on this basis, wherein due to the nonstrict provision of the magnetic nesting condition there exists the finite but sufficiently high critical magnetization [ru

  11. The global existence problem and cosmic censorship in general relativity

    International Nuclear Information System (INIS)

    Moncrief, V.; Eardley, D.M.

    1981-01-01

    Two global existence conjectures for the Einstein equations are formulated and their relevance to the cosmic censorship conjecture discussed. It is argued that the reformulation of the cosmic censorship conjecture as a global existence problem renders it more amenable to direct analytical attack. To demonstrate the facility of this approach the cosmological version of the global existence conjecture is proved for the Gowdy spacetimes on T 3 X R. (author)

  12. 40 CFR 407.74 - Pretreatment standards for existing sources.

    Science.gov (United States)

    2010-07-01

    ...) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED FRUITS AND VEGETABLES PROCESSING POINT SOURCE CATEGORY Canned and Preserved Vegetables Subcategory § 407.74 Pretreatment standards for existing sources...

  13. INFORMATION SECURITY RISK ASSESSMENT USING EXISTING LEGAL AND METHODOLOGICAL BASE

    Directory of Open Access Journals (Sweden)

    A. I. Trubei

    2015-01-01

    Full Text Available The article provides a survey of the existing regulatory framework for information security riskmanagement. Practical methods for information security risk and vulnerability assessment are proposed.

  14. Expandable External Payload Carrier for Existing Launch Vehicles, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Numerous existing launch vehicles have excess performance that is not being optimized. By taking advantage of excess, unused, performance, additional NASA...

  15. Further evidence for magnetic charge from meson spectroscopy

    International Nuclear Information System (INIS)

    Akers, D.

    1987-01-01

    Recently evidence was presented for the existence of magnetic charge from Zeeman splitting in meson states. The model by Akers predicted the existence of a new eta meson at 1814 MeV with I/sup G/ (J/sup PC/) = O + (O -+ ). Experimental evidence for this new meson is cited and discussed

  16. Tachyons imply the existence of a privileged frame

    Energy Technology Data Exchange (ETDEWEB)

    Sjoedin, T.; Heylighen, F.

    1985-12-16

    It is shown that the existence of faster-than-light signals (tachyons) would imply the existence (and detectability) of a privileged inertial frame and that one can avoid all problems with reversed-time order only by using absolute synchronization instead of the standard one. The connection between these results and the EPR-paradox is discussed.

  17. Safety assessment of existing highway bridges and viaducts

    NARCIS (Netherlands)

    Maljaars, J.; Steenbergen, R.; Abspoel, L.; Kolstein, M.H.

    2012-01-01

    The assessment of the structural safety of existing br idges and viaducts becomes increasingly important in many countries owing to an increase in traffic loads. Most existing standards, however, are developed for the design of new structures. For this reason, an assessment method for determining

  18. Neural Network for Optimization of Existing Control Systems

    DEFF Research Database (Denmark)

    Madsen, Per Printz

    1995-01-01

    The purpose of this paper is to develop methods to use Neural Network based Controllers (NNC) as an optimization tool for existing control systems.......The purpose of this paper is to develop methods to use Neural Network based Controllers (NNC) as an optimization tool for existing control systems....

  19. The Relationship among Localization Skill, Existence Constancy and Object Permanence.

    Science.gov (United States)

    Townes-Rosenwein, Linda

    Two component skills of object permanence were studied: existence constancy -- the infants' ability to expect that an object continues to exist after it is hidden, and localization skill -- infants' ability to search in the correct place for a hidden object. Contradictions within the literature may occur because of task lability caused by failure…

  20. 40 CFR 63.312 - Existing regulations and requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Existing regulations and requirements. 63.312 Section 63.312 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... National Emission Standards for Coke Oven Batteries § 63.312 Existing regulations and requirements. (a) The...

  1. Existence of solutions of nonlinear integrodifferential equations of ...

    Indian Academy of Sciences (India)

    The results are obtained by using semigroup theory and the Schauder fixed point ... The problem of existence of solutions of evolution equations with nonlocal ... we assume that there exists an operator E on DЕEЖИX given by the formula.

  2. The solution of location problems with certain existing facility structures

    DEFF Research Database (Denmark)

    Juel, Henrik; Love, Robert F.

    1983-01-01

    It is known that in the Euclidean distance case, the optimal minisum location of a new facility in relation to four existing facilities is at the intersection of the two lines joining two pairs of the facilities. The authors extend this concept to minisum problems having any even number of existing...... facilities and characterized by generalized distance norms...

  3. Existence of the Stark-Wannier quantum resonances

    Energy Technology Data Exchange (ETDEWEB)

    Sacchetti, Andrea, E-mail: andrea.sacchetti@unimore.it [Department of Physics, Computer Sciences and Mathematics, University of Modena e Reggio Emilia, Modena (Italy)

    2014-12-15

    In this paper, we prove the existence of the Stark-Wannier quantum resonances for one-dimensional Schrödinger operators with smooth periodic potential and small external homogeneous electric field. Such a result extends the existence result previously obtained in the case of periodic potentials with a finite number of open gaps.

  4. Does Absolute Synonymy exist in Owere-Igbo? | Omego | AFRREV ...

    African Journals Online (AJOL)

    Among Igbo linguistic researchers, determining whether absolute synonymy exists in Owere–Igbo, a dialect of the Igbo language predominantly spoken by the people of Owerri, Imo State, Nigeria, has become a thorny issue. While some linguistic scholars strive to establish that absolute synonymy exists in the lexical ...

  5. Existence and attractors of solutions for nonlinear parabolic systems

    Directory of Open Access Journals (Sweden)

    Hamid El Ouardi

    2001-01-01

    Full Text Available We prove existence and asymptotic behaviour results for weak solutions of a mixed problem (S. We also obtain the existence of the global attractor and the regularity for this attractor in $\\left[H^{2}(\\Omega \\right] ^{2}$ and we derive estimates of its Haussdorf and fractal dimensions.

  6. Remarks on the existence of non equilibrium dynamics

    International Nuclear Information System (INIS)

    Marchioro, C.; Pellegrinotti, A.; Pulvirenti, M.

    1981-01-01

    The authors give an existence theorem for the dynamics of an infinite system of anharmonic oscillators. They obtain another proof of the existence of the dynamics in the case of one-dimensional system of infinitely many particles interacting via a bounded potential. The case of very singular potential is also solved. (Auth.)

  7. Global existence of small solutions to semilinear Schroedinger equations

    International Nuclear Information System (INIS)

    Chihara, Hiroyuki

    1996-01-01

    We present global existence theorem for semilinear Schrodinger equations. In general, Schrodinger-type equations do not admit the classical energy estimates. To avoid this difficulty, we use S. Doi's method for linear Schrodinger-type equations. Combining his method and L p -L q estimates, we prove the global existence of solutions with small initial data

  8. 49 CFR 223.15 - Requirements for existing passenger cars.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Requirements for existing passenger cars. 223.15... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION SAFETY GLAZING STANDARDS-LOCOMOTIVES, PASSENGER CARS AND CABOOSES Specific Requirements § 223.15 Requirements for existing passenger cars. (a) Passenger cars built or...

  9. Existing knowledge related to mainstreaming IKS into Educational ...

    African Journals Online (AJOL)

    The study aimed at determining existing knowledge related to mainstreaming of IKS into education system. The qualitative research methodology was appropriate for this study to explore and describe the mainstreaming of IKS into the existing education system. The study included 10 school teachers (5male and 5 females) ...

  10. An existence result of energy minimizer maps between Riemannian polyhedra

    International Nuclear Information System (INIS)

    Bouziane, T.

    2004-06-01

    In this paper, we prove the existence of energy minimizers in each free homotopy class of maps between polyhedra with target space without focal points. Our proof involves a careful study of some geometric properties of Riemannian polyhedra without focal points. Among other things, we show that on the relevant polyhedra, there exists a convex supporting function. (author)

  11. 30 CFR 784.12 - Operation plan: Existing structures.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Operation plan: Existing structures. 784.12... PLAN § 784.12 Operation plan: Existing structures. (a) Each application shall contain a description of... and reclamation operation. The description shall include: (1) Location; (2) Plans of the structure...

  12. 30 CFR 780.12 - Operation plan: Existing structures.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Operation plan: Existing structures. 780.12... PLAN § 780.12 Operation plan: Existing structures. (a) Each application shall contain a description of... and reclamation operation. The description shall include— (1) Location; (2) Plans of the structure...

  13. Belief and disbelief in the existence of genetic risk factors for suicide: cross-cultural comparisons.

    Science.gov (United States)

    Voracek, Martin

    2007-12-01

    There is evidence for widespread disbelief in the genetics of suicide, despite recent research progress in this area and convergent evidence supporting a role for genetic factors. This study analyzed the beliefs held in 8 samples (total N = 1224) of various types (psychology, medical, and various undergraduates, psychology graduates, and the general population) from 6 countries located on 3 continents (Austria, Canada, Malaysia, Romania, United Kingdom, and the USA). Endorsement rates for the existence of genetic risk factors for suicide ranged from 26% and 30% (Austrian psychology undergraduates and general population) to around 50% (psychology undergraduates in the USA and United Kingdom). In the 8 samples, respondents' sex, age, religiosity, political orientation, and other demographic variables were, for the most part, unrelated, but overall knowledge about suicide throughout was related positively to endorsement rates. Consistent with previous research, across a considerable variety of sample types and cultural settings there was no evidence for a clear majority believing in genetic bases for suicide.

  14. Kierkegaard e a existência possível

    Directory of Open Access Journals (Sweden)

    Roberto S. Kahlmeyer-Mertens

    2013-05-01

    Full Text Available Resumo: A relação entre a existência e a possibilidade, objeto deste artigo, merece especial atenção quando se trata de Kierkegaard. Isso porque, estes dois conceitos ocupam papéis primordiais na filosofia do autor, constituindo, justamente, o ponto a partir do qual o pensador se distancia criticamente da tradição filosófica. Caracterizar sumariamente os conceitos de existência e possibilidade na filosofia de Kierkegaard, bem como ambientar o filósofo em sua época como um pensador da existência, para além do rótulo de “existencialista”, são nossos presentes objetivos.   Palavras-chave: Kierkegaard, filosofia da existência, existência, possibilidade

  15. Asthma and obesity in children: current evidence and potential systems biology approaches.

    Science.gov (United States)

    Frey, U; Latzin, P; Usemann, J; Maccora, J; Zumsteg, U; Kriemler, S

    2015-01-01

    Both obesity and asthma are highly prevalent, complex diseases modified by multiple factors. Genetic, developmental, lung mechanical, immunological and behavioural factors have all been suggested as playing a causal role between the two entities; however, their complex mechanistic interactions are still poorly understood and evidence of causality in children remains scant. Equally lacking is evidence of effective treatment strategies, despite the fact that imbalances at vulnerable phases in childhood can impact long-term health. This review is targeted at both clinicians frequently faced with the dilemma of how to investigate and treat the obese asthmatic child and researchers interested in the topic. Highlighting the breadth of the spectrum of factors involved, this review collates evidence regarding the investigation and treatment of asthma in obese children, particularly in comparison with current approaches in 'difficult-to-treat' childhood asthma. Finally, the authors propose hypotheses for future research from a systems-based perspective. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  16. A coupled chemotaxis-fluid model: Global existence

    KAUST Repository

    Liu, Jian-Guo; Lorz, Alexander

    2011-01-01

    We consider a model arising from biology, consisting of chemotaxis equations coupled to viscous incompressible fluid equations through transport and external forcing. Global existence of solutions to the Cauchy problem is investigated under certain conditions. Precisely, for the chemotaxis-Navier- Stokes system in two space dimensions, we obtain global existence for large data. In three space dimensions, we prove global existence of weak solutions for the chemotaxis-Stokes system with nonlinear diffusion for the cell density.© 2011 Elsevier Masson SAS. All rights reserved.

  17. A coupled chemotaxis-fluid model: Global existence

    KAUST Repository

    Liu, Jian-Guo

    2011-09-01

    We consider a model arising from biology, consisting of chemotaxis equations coupled to viscous incompressible fluid equations through transport and external forcing. Global existence of solutions to the Cauchy problem is investigated under certain conditions. Precisely, for the chemotaxis-Navier- Stokes system in two space dimensions, we obtain global existence for large data. In three space dimensions, we prove global existence of weak solutions for the chemotaxis-Stokes system with nonlinear diffusion for the cell density.© 2011 Elsevier Masson SAS. All rights reserved.

  18. A comprehensive review of HIV/STI prevention and sexual and reproductive health services among sex Workers in Conflict-Affected Settings: call for an evidence- and rights-based approach in the humanitarian response.

    Science.gov (United States)

    Ferguson, Alyssa; Shannon, Kate; Butler, Jennifer; Goldenberg, Shira M

    2017-01-01

    While the conditions in emergency humanitarian and conflict-affected settings often result in significant sex work economies, there is limited information on the social and structural conditions of sex work in these settings, and the impacts on HIV/STI prevention and access to sexual and reproductive health (SRH) services for sex workers. Our objective was to comprehensively review existing evidence on HIV/STI prevention and access to SRH services for sex workers in conflict-affected settings globally. We conducted a comprehensive review of all peer review (both epidemiological and qualitative) and grey literature published in the last 15 years (2000-2015), focusing on 1) HIV/STI vulnerability or prevention, and/or 2) access to SRH services for sex workers in conflict-affected settings. Five databases were searched, using combinations of sex work, conflict/mobility, HIV/STI, and SRH service terms. Relevant peer-reviewed and grey literature were also hand-searched, and key papers were cross-referenced for additional material. Five hundred fifty one records were screened and 416 records reviewed. Of 33 records describing HIV/STI prevention and/or access to SRH services among sex workers in conflict-affected settings, 24 were from sub-Saharan Africa; 18 studies described the results of primary research (13 quantitative, 3 qualitative, 2 mixed-methods) and 15 were non-primary research (e.g., commentaries, policy reports, programmatic manuals). Available evidence indicated that within conflict-affected settings, SWs' capacity to engage in HIV/STI prevention and access SRH services is severely undermined by social and structural determinants including widespread violence and human rights violations, the collapse of livelihoods and traditional social structures, high levels of displacement, and difficulties accessing already scant health services due to stigma, discrimination and criminalization. This review identified significant gaps in HIV/STI and SRH research, policy

  19. 40 CFR 407.64 - Pretreatment standards for existing sources.

    Science.gov (United States)

    2010-07-01

    ...) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED FRUITS AND VEGETABLES PROCESSING POINT SOURCE CATEGORY Canned and Preserved Fruits Subcategory § 407.64 Pretreatment standards for existing sources. Any...

  20. Branding in children: a barbaric practice still exists in India.

    Science.gov (United States)

    Patra, Pratap Kumar

    2016-01-01

    Branding is an inhuman traditional practice most commonly employed to treat various disorders in neonates and children in certain community in India. Though stringent law exists to prevent such harmful practices, cases of branding is not uncommon in current era.

  1. Non-existence of limit cycles for planar vector fields

    Directory of Open Access Journals (Sweden)

    Jaume Gine

    2014-03-01

    Full Text Available This article presents sufficient conditions for the non-existence of limit cycles for planar vector fields. Classical methods for the nonexistence of limit cycles are connected with the theory developed here.

  2. 31 CFR 370.26 - What limitations exist on liability?

    Science.gov (United States)

    2010-07-01

    ... TRANSFERS RELATING TO UNITED STATES SECURITIES Debit Entries § 370.26 What limitations exist on liability? If we sustain a loss because a financial institution fails to handle an entry in accordance with this...

  3. Protection of continued economic existence and major changes. 1. paper

    International Nuclear Information System (INIS)

    Backherms, J.

    1980-01-01

    On the issue of protecting continued economic existence according to Sect. 18 of the Atomic Energy Law, a difference is made between changes occurring in the environment of the plant, in the existing knowledge in science and technology, and changes occurring in the safety philosophy held by the authorities. In case of conditions being subsequently imposed because of a change in the existing knowledge in science and technology, the liability of the authorities to pay compensation is ruled out according to Sect. 18, para. 2 No. 3 of the Atomic Energy Law. The difference made between a change in the safety philosophy held by the authorities and a change in the existing knowledge in science and technology seems to be obvious. In the first case it is a matter of changing the legal evaluation of unchanged technological findings, in the legal evaluation, however, the licence granted has to have a lasting effect on principle. (HP) [de

  4. Existence results for anisotropic discrete boundary value problems

    Directory of Open Access Journals (Sweden)

    Avci Avci

    2016-06-01

    Full Text Available In this article, we prove the existence of nontrivial weak solutions for a class of discrete boundary value problems. The main tools used here are the variational principle and critical point theory.

  5. Possible existence of wormholes in the central regions of halos

    Energy Technology Data Exchange (ETDEWEB)

    Rahaman, Farook, E-mail: rahaman@iucaa.ernet.in [Department of Mathematics, Jadavpur University, Kolkata 700032, West Bengal (India); Salucci, P., E-mail: salucci@sissa.it [SISSA, International School for Advanced Studies, Via Bonomea 265, 34136, Trieste (Italy); INFN, Sezione di Trieste, Via Valerio 2, 34127, Trieste (Italy); Kuhfittig, P.K.F., E-mail: kuhfitti@msoe.edu [Department of Mathematics, Milwaukee School of Engineering, Milwaukee, WI 53202-3109 (United States); Ray, Saibal, E-mail: saibal@iucaa.ernet.in [Department of Physics, Government College of Engineering and Ceramic Technology, Kolkata 700010, West Bengal (India); Rahaman, Mosiur, E-mail: mosiurju@gmail.com [Department of Mathematics, Meghnad Saha Institute of Technology, Kolkata 700150 (India)

    2014-11-15

    An earlier study (Rahaman, et al., 2014 and Kuhfittig, 2014) has demonstrated the possible existence of wormholes in the outer regions of the galactic halo, based on the Navarro–Frenk–White (NFW) density profile. This paper uses the Universal Rotation Curve (URC) dark matter model to obtain analogous results for the central parts of the halo. This result is an important compliment to the earlier result, thereby confirming the possible existence of wormholes in most of the spiral galaxies. - Highlights: • Earlier we showed possible existence of wormholes in the outer regions of halo. • We obtain here analogous results for the central parts of the galactic halo. • Our result is an important compliment to the earlier result. • This confirms possible existence of wormholes in most of the spiral galaxies.

  6. DOES ABSOLUTE SYNONYMY EXIST IN OWERE-IGBO?

    African Journals Online (AJOL)

    USER

    The researcher also interviewed native speakers of the dialect. The study ... The word 'synonymy' means sameness of meaning, i.e., a relationship in which more ... whether absolute synonymy exists in Owere–Igbo or not. ..... 'close this book'.

  7. Existence of Solutions of Nonlinear Integrodifferential Equations of ...

    Indian Academy of Sciences (India)

    Abstract. In this paper we prove the existence of mild and strong solutions of a nonlinear integrodifferential equation of Sobolev type with nonlocal condition. The results are obtained by using semigroup theory and the Schauder fixed point theorem.

  8. Problem of mathematical deduction of the existence of black holes

    Directory of Open Access Journals (Sweden)

    Yuan-Shun Chin

    1990-01-01

    Full Text Available The mathematical proof of existence of Black Hole is based on the assumption of mass being independent of speed. Considering the effect of special relativity of the dependence of mass with speed there is no Black hole.

  9. On the existence and dynamics of braneworld black holes

    International Nuclear Information System (INIS)

    Fitzpatrick, Andrew Liam; Randall, Lisa; Wiseman, Toby

    2006-01-01

    Based on holographic arguments Tanaka and Emparan et al have claimed that large localized static black holes do not exist in the one-brane Randall-Sundrum model. If such black holes are time-dependent as they propose, there are potentially significant phenomenological and theoretical consequences. We revisit the issue, arguing that their reasoning does not take into account the strongly coupled nature of the holographic theory. We claim that static black holes with smooth metrics should indeed exist in these theories, and give a simple example. However, although the existence of such solutions is relevant to exact and numerical solution searches, such static solutions might be dynamically unstable, again leading to time dependence with phenomenological consequences. We explore a plausible instability, suggested by Tanaka, analogous to that of Gregory and Laflamme, but argue that there is no reliable reason at this point to assume it must exist

  10. A corrosion monitoring system for existing reinforced concrete structures.

    Science.gov (United States)

    2015-05-01

    This study evaluated a multi-parameter corrosion monitoring system for existing reinforced concrete structures in chloride-laden service environments. The system was fabricated based on a prototype concrete corrosion measurement system that : had bee...

  11. Report on the Pre-existing Condition Insurance Plan Program

    Data.gov (United States)

    U.S. Department of Health & Human Services — Before the Affordable Care Act, Americans with pre-existing conditions who did not receive health coverage through their employers had few affordable options to get...

  12. Existence for a class of discrete hyperbolic problems

    Directory of Open Access Journals (Sweden)

    Luca Rodica

    2006-01-01

    Full Text Available We investigate the existence and uniqueness of solutions to a class of discrete hyperbolic systems with some nonlinear extreme conditions and initial data, in a real Hilbert space.

  13. Existence of Weak Solutions for a Nonlinear Elliptic System

    Directory of Open Access Journals (Sweden)

    Gilbert RobertP

    2009-01-01

    Full Text Available We investigate the existence of weak solutions to the following Dirichlet boundary value problem, which occurs when modeling an injection molding process with a partial slip condition on the boundary. We have in ; in ; , and on .

  14. Existence of Positive Solutions for Nonlinear Eigenvalue Problems

    Directory of Open Access Journals (Sweden)

    Wong Fu-Hsiang

    2010-01-01

    Full Text Available We use a fixed point theorem in a cone to obtain the existence of positive solutions of the differential equation, , , with some suitable boundary conditions, where is a parameter.

  15. comparative performance evaluation of an existing and modified

    African Journals Online (AJOL)

    PROF. BARTH EKWEME

    and fan speeds of 2800 rpm as against the existing cylinder and fan speeds of 934 rpm. The performance evaluation for ... KEYWORDS: Acha, fonio, dehuller, performance evaluation, ... centrifugal force as a result of the rotation of the cylinder.

  16. Newspaper and internet display advertising: Co-existence or substitution?

    OpenAIRE

    Lindstädt, Nadine; Budzinski, Oliver

    2012-01-01

    Newspapers have been experiencing declining circulation figures and diminishing advertising revenues for several years – both effects might pose a threat to the continuing existence of (print) newspapers. In an earlier paper, Lindstädt & Budzinski (2011) argued from a theoretical viewpoint that industry-specific patterns exist that determine substitution or complementation effects between internet and newspaper advertising. It was argued that retail advertising, in particular, may offer a nic...

  17. Evaluation of the integrity of existing NFS waste tanks

    International Nuclear Information System (INIS)

    1977-12-01

    Various means of investigating the integrity of the existing NFS waste tanks are presented, including: visual inspection, ultrasonic testing, acoustic-emission monitoring, radiography, and forced-vibration testing. The experience that exists in performing such investigations of high-level radioactive waste tanks is documented, including: visual inspections, photography, wall-thickness measurements, and forced-vibration testing. An evaluation is made on the relative merits of the presented inspection and testing alternatives

  18. Non-existence criteria for Laurent polynomial first integrals

    Directory of Open Access Journals (Sweden)

    Shaoyun Shi

    2003-01-01

    Full Text Available In this paper we derived some simple criteria for non-existence and partial non-existence Laurent polynomial first integrals for a general nonlinear systems of ordinary differential equations $\\dot x = f(x$, $x \\in \\mathbb{R}^n$ with $f(0 = 0$. We show that if the eigenvalues of the Jacobi matrix of the vector field $f(x$ are $\\mathbb{Z}$-independent, then the system has no nontrivial Laurent polynomial integrals.

  19. Existence of solitary waves in dipolar quantum gases

    KAUST Repository

    Antonelli, Paolo; Sparber, Christof

    2011-01-01

    We study a nonlinear Schrdinger equation arising in the mean field description of dipolar quantum gases. Under the assumption of sufficiently strong dipolar interactions, the existence of standing waves, and hence solitons, is proved together with some of their properties. This gives a rigorous argument for the possible existence of solitary waves in BoseEinstein condensates, which originate solely due to the dipolar interaction between the particles. © 2010 Elsevier B.V. All rights reserved.

  20. The existence and persistence of household financial hardship

    OpenAIRE

    Brown, S.; Ghosh, P.; Taylor, K.

    2012-01-01

    We investigate the existence and persistence of financial hardship at the household level using data from the British Household Panel Survey. Our modelling strategy makes three important contributions to the existing literature on household finances. Firstly, we model nine different types of household financial problems within a joint framework, allowing for correlation in the random effects across the nine equations. Secondly, we develop a dynamic framework in order to model the persistence ...

  1. Existence of solutions to quasilinear Schrodinger equations with indefinite potential

    Directory of Open Access Journals (Sweden)

    Zupei Shen

    2015-04-01

    Full Text Available In this article, we study the existence and multiplicity of solutions of the quasilinear Schrodinger equation $$ -u''+V(xu-(|u| ^2''u=f(u $$ on $\\mathbb{R}$, where the potential $V$ allows sign changing and the nonlinearity satisfies conditions weaker than the classical Ambrosetti-Rabinowitz condition. By a local linking theorem and the fountain theorem, we obtain the existence and multiplicity of solutions for the equation.

  2. How Do We Know Protons, Electrons, and Quarks Really Exist?

    Science.gov (United States)

    Robertson, Bill

    2005-01-01

    Scientific explanations often make use of things that cannot be seen or felt, such as protons, electrons, and quarks. Do these things really exist? If so, how do is it known that they exist? Imagine being enclosed in a completely dark room with no light at all and not being able to see a thing. Being chained to a chair somewhere in the room, and…

  3. Existence of solitary waves in dipolar quantum gases

    KAUST Repository

    Antonelli, Paolo

    2011-02-01

    We study a nonlinear Schrdinger equation arising in the mean field description of dipolar quantum gases. Under the assumption of sufficiently strong dipolar interactions, the existence of standing waves, and hence solitons, is proved together with some of their properties. This gives a rigorous argument for the possible existence of solitary waves in BoseEinstein condensates, which originate solely due to the dipolar interaction between the particles. © 2010 Elsevier B.V. All rights reserved.

  4. Building the evidence to grow female entrepreneurship | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-09-22

    Sep 22, 2016 ... Interest in evidence about women's empowerment is on the rise. ... to concentrate in sectors that are often less rewarding, unregistered, and with limited growth prospects. ... Some evidence exists on how interventions such as training, ... given that they operate at the intersection of evidence and advocacy, ...

  5. Interfacing the existing cask fleet with the MRS

    International Nuclear Information System (INIS)

    Doman, J.W.; Hahn, R.E.

    1992-01-01

    This paper reports that the Department of Energy (DOE) is considering the possibility of using the existing fleet of casks to achieve spent fuel receipt at the Monitored Retrievable Storage (MRS) facility. The existing cask fleet includes the NLI-1/2, the NAC-LWT, the TN-8 (and TN-8L), the TN-9, and the IF-300 casks. Other casks may be available, but their status is not certain. Use of the existing cask fleet at the MRS places additional design requirements on the system, and specifically affects the cask-to-MRS interface. The decision to use the existing cask fleet also places additional demands on training needs and operator certification, and the configuration management system. Some existing cask designs may not be able to mate with a bottom opening hot cell MRS. Use of the existing cask fleet also greatly increases the number of shipments that must be received, to the point that a facility larger than originally envisioned may be required

  6. Study of structural reliability of existing concrete structures

    Science.gov (United States)

    Druķis, P.; Gaile, L.; Valtere, K.; Pakrastiņš, L.; Goremikins, V.

    2017-10-01

    Structural reliability of buildings has become an important issue after the collapse of a shopping center in Riga 21.11.2013, caused the death of 54 people. The reliability of a building is the practice of designing, constructing, operating, maintaining and removing buildings in ways that ensure maintained health, ward suffered injuries or death due to use of the building. Evaluation and improvement of existing buildings is becoming more and more important. For a large part of existing buildings, the design life has been reached or will be reached in the near future. The structures of these buildings need to be reassessed in order to find out whether the safety requirements are met. The safety requirements provided by the Eurocodes are a starting point for the assessment of safety. However, it would be uneconomical to require all existing buildings and structures to comply fully with these new codes and corresponding safety levels, therefore the assessment of existing buildings differs with each design situation. This case study describes the simple and practical procedure of determination of minimal reliability index β of existing concrete structures designed by different codes than Eurocodes and allows to reassess the actual reliability level of different structural elements of existing buildings under design load.

  7. "Does a Compensation Culture Exist in the United Kingdom?"

    OpenAIRE

    Harvey, Edward

    2008-01-01

    Abstract This dissertation investigates the issue of compensation culture and the evidence for it in the United Kingdom. Insight into the relationship between Tort Law and Insurance finds that the role of insurance is largely misinterpreted in the field. Insurance companies have many mechanisms to control behaviour, ensure personal responsibility is upheld, reduce moral hazard and promote risk management. This paper proposes that claims increases might be more evident in areas of compensa...

  8. Existence conditions of optimal trajectories in dynamic control processes; Conditions d'existence de trajectoires optimales des processus dynamiques commandes

    Energy Technology Data Exchange (ETDEWEB)

    Bonnemay-Juricek, L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1968-07-01

    The existence of solutions in the optimal control problems with free endpoints is studied in this report and existence conditions are established without the usual assumption that the control region is convex. Furthermore the results, in order to be of some utility in physical applications, are expressed only by means of conditions on the parameters defining the system. (author) [French] Ce rapport etudie l'existence de solutions optimales dans les problemes de commande ou le point terminal est libre et ou la duree de l'evolution du systeme a optimiser est connue. Des conditions d'existence y sont formulees sans recourir a l'hypothese usuelle de convexite du domaine des valeurs des commandes. De plus on a cherche a rendre utilisables les resultats en ne faisant porter les conditions que sur les parametres directement accessibles du systeme. (auteur)

  9. Greening Existing Buildings in Contemporary Iraqi Urban Reality/ Virtual Model

    Directory of Open Access Journals (Sweden)

    Saba Jabar Neama Al-Khafaji

    2015-11-01

    Full Text Available The approach of greening existing buildings, is an urgent necessity, because the greening operation provides the speed and optimal efficiency in the environmental performance, as well as keeping up with the global green architecture revolution. Therefore, greening existing buildings in Iraq is important for trends towards renewable energies, because of what the country went through economic conditions and crises and wars which kept the country away from what took place globally in this issue. The research problem is: insufficient knowledge about the importance and the mechanism of the greening of existing buildings, including its environmental and economic dimensions, by rationalization of energy consumption and preserving the environment. The research objective is: clarifying the importance of greening existing buildings environmentally and economically, providing a virtual experience for greening the presidency building of Baghdad University, through advanced computer program. The main conclusions is: there is difference representing by reducing the disbursed thermal loads amount for cooling in summer and heating in winter through the use of computerized program (DesignBuilder and that after the implementation of greening operations on the building envelope, which confirms its effectiveness in raising the energy performance efficiency inside the building. Hence, the importance of the application of greening existing buildings approach in Iraq, to bring back Iraqi architecture to environmental and local track proper.

  10. Seismic performance of existing R.C. framed buildings

    Directory of Open Access Journals (Sweden)

    Sameh A. El-Betar

    2017-08-01

    Full Text Available The earthquakes disasters basically occur due to buildings damage not because of the earth shaking. Therefore, the countries have being updated the seismic codes. The seismic loads for buildings design in Egyptian Code have been changed from (EC-1994 to (ECP-201, 2012. On the other hand, the need is raised to study the vulnerability of existing buildings, which can be divided into the buildings designed to resist the gravity loads only (GLD and the buildings designed according to Egyptian code (EC-1994. Comparison between forces due to Egyptian code for loads (EC-1994 and (ECP-201, 2012 is carried out on the multi-stories R.C. framed buildings which are the most common type of existing buildings in Egypt. To investigate the vulnerability of existing buildings, nonlinear static pushover analysis is conducted to evaluate the real strength of the existing buildings. Moreover, it is considered a useful and effective tool for the performance of three framed buildings: 3, 6 and 10 stories due to expected future earthquakes. Finally, it is found that the vulnerability of existing GLD buildings occurs at expected ground accelerations (ag greater than 0.125 g in Egyptian seismic map, while the EC-94 designed buildings behave elastically up to (ag equals to 0.2 g and above that a slight damage may occur.

  11. Energy and architecture: improvement of energy performance in existing buildings

    Energy Technology Data Exchange (ETDEWEB)

    Haase, Matthias; Wycmans, Annemie; Solbraa, Anne; Grytli, Eir

    2011-07-01

    This book aims to give an overview of different aspects of retrofitting existing buildings. The target group is students of architecture and building engineering as well as building professionals. Eight out of ten buildings which we will inhabit in 2050 already exist. This means that a great potential for reducing our carbon footprint lies in the existing building stock. Students from NTNU have used the renovation of a 1950s school building at Linesoeya in Soer-Trondelag as a case to increase their awareness and knowledge about the challenges building professionals need to overcome to unite technical details and high user quality into good environmental performance. The students were invited by the building owners and initiators of LIPA Eco Project to contribute to its development: By retrofitting an existing building to passive house standards and combining this with energy generated on site, LIPA Eco Project aims to provide a hands-on example with regard to energy efficiency, architectural design and craftsmanship for a low carbon society. The overall goal for this project is to raise awareness regarding resource efficiency measures in architecture and particularly in existing building mass.(au)

  12. Existence domains of dust-acoustic solitons and supersolitons

    International Nuclear Information System (INIS)

    Maharaj, S. K.; Bharuthram, R.; Singh, S. V.; Lakhina, G. S.

    2013-01-01

    Using the Sagdeev potential method, the existence of large amplitude dust-acoustic solitons and supersolitons is investigated in a plasma comprising cold negative dust, adiabatic positive dust, Boltzmann electrons, and non-thermal ions. This model supports the existence of positive potential supersolitons in a certain region in parameter space in addition to regular solitons having negative and positive potentials. The lower Mach number limit for supersolitons coincides with the occurrence of double layers whereas the upper limit is imposed by the constraint that the adiabatic positive dust number density must remain real valued. The upper Mach number limits for negative potential (positive potential) solitons coincide with limiting values of the negative (positive) potential for which the negative (positive) dust number density is real valued. Alternatively, the existence of positive potential solitons can terminate when positive potential double layers occur

  13. The Existence of a Sticking Region in Free Weight Squats

    Directory of Open Access Journals (Sweden)

    Tillaar Roland van den

    2014-10-01

    Full Text Available The aim of this study was to investigate the existence of the sticking region in two legged free weight squats. Fifteen resistance-training males (age 24 ± 4 years, body mass 82 ± 11 kg, body height 179 ± 6 cm with 6 ± 3 years of resistance-training experience performed 6-RM in free weight squats. The last repetition was analyzed for the existence of a sticking region. Only in 10 out of 15 participants a sticking region was observed. The observed sticking region was much shorter than in the bench press. Furthermore, rectus femoris decreased the EMG activity in contrast to increased EMG activity in biceps femoris around the sticking and surrounding region. No significant change in EMG activity was found for the lateral and medial vastus muscles. It is suggested that a combination of these muscle activity changes could be one of the causes of the existence of the sticking region in free weight squats

  14. The existence of a sticking region in free weight squats.

    Science.gov (United States)

    van den Tillaar, Roland; Andersen, Vidar; Saeterbakken, Atle Hole

    2014-09-29

    The aim of this study was to investigate the existence of the sticking region in two legged free weight squats. Fifteen resistance-training males (age 24 ± 4 years, body mass 82 ± 11 kg, body height 179 ± 6 cm) with 6 ± 3 years of resistance-training experience performed 6-RM in free weight squats. The last repetition was analyzed for the existence of a sticking region. Only in 10 out of 15 participants a sticking region was observed. The observed sticking region was much shorter than in the bench press. Furthermore, rectus femoris decreased the EMG activity in contrast to increased EMG activity in biceps femoris around the sticking and surrounding region. No significant change in EMG activity was found for the lateral and medial vastus muscles. It is suggested that a combination of these muscle activity changes could be one of the causes of the existence of the sticking region in free weight squats.

  15. Islamic Banking Existence and Domestic Credit: Study at Seven Countries

    Directory of Open Access Journals (Sweden)

    Hamdan Yuafi

    2017-05-01

    Full Text Available This paper empirically investigates the determinants of domestic credit across a wide range of 7 countries; these are United Kingdom, Malaysia, Egypt, Kuwait, Qatar, Bahrain and Indonesia. We use dynamic panel estimation to examine effects of exchange rate, inflation, lending interest rate, banking crisis and existence of wholesale Islamic banking on domestic credit. We obtain several notable empirical results. First, the lending interest rate, banking crisis negatively and insignificantly contribute to domestic credit. The existence of Islamic bank has positive and insignificant contribution to domestic credit, while exchange rate positively and significantly contributes to domestic credit.  Inflation negatively and significantly contributes to domestic credit. Second, banking crisis and existence of wholesale Islamic banking show insignificant effect on domestic credit. Third, we find that today’s domestic credit is depended on domestic credit in the previous year.DOI: 10.15408/aiq9i2.4906

  16. Existing sustainable renovation concepts for single-family houses

    DEFF Research Database (Denmark)

    Tommerup, Henrik M.; Vanhoutteghem, Lies; Svendsen, Svend

    2010-01-01

    In the Nordic Innovation Centre Project, SuccessFamilies, the main objective is to change the business environment in order to speed up the implementation of sustainable renovation of single-family houses – proposing new service concepts that will combine both the technical solutions, financing...... with individual solutions, traditional warehouses ”do-it-yourself-shops” and some actors marketing single products. To speed up the implementation of sustainable renovation of single-family houses there is a great need for full-service packages. Existing technical renovation concepts, typically focusing...... services as well as other promoting issues to overcome the behavioural, organizational, legal and social barriers that exist in sustainable renovation. A starting point for such a change has been to get an overview of the existing sustainable renovation concepts, i.e. full-service concepts and technical...

  17. Intersubjective Dimension of Existence in the Philosophy of Gabriel Marcel

    Directory of Open Access Journals (Sweden)

    Martín Grassi

    2016-05-01

    Full Text Available The present work intends to introduce the reader to the essential dimension of intersubjectivity in personal existence in Gabriel Marcel’s philosophy. We will first attend to the characterization of persona; secondly, how we should understand the terms I and the other in concrete interpersonal relationships; in the third place, we will analize the way in which the other is given as an other, through the notion of presence. The main objective of this article is to show that personal existence is uncomprehensible without its reference to the other, that is to say, that identity has no sense without alterity. Moreover, the essential intencionality of identity to alterity does not imply only a practical or accidental character, but a metaphysical one, as communion constitutes the very being of personal existence.

  18. Existing PON Infrastructure Supported Hybrid Fiber-Wireless Sensor Networks

    DEFF Research Database (Denmark)

    Yu, Xianbin; Zhao, Ying; Deng, Lei

    2012-01-01

    We propose a hybrid fiber wireless sensor network based on the existing PON infrastructure. The feasibility of remote sensing and PON convergence is experimentally proven by transmitting direct-sequence spread-spectrum wireless sensing and 2.5Gbps GPON signals.......We propose a hybrid fiber wireless sensor network based on the existing PON infrastructure. The feasibility of remote sensing and PON convergence is experimentally proven by transmitting direct-sequence spread-spectrum wireless sensing and 2.5Gbps GPON signals....

  19. Existing and Expected Service Quality of Grameenphone Users in Bangladesh

    Directory of Open Access Journals (Sweden)

    Azmat Ullah

    2015-12-01

    Full Text Available The Grameenphone (GP is a market leader in the telecommunication industry in Bangladesh. This study investigates the existing and expected service quality of Grameenphone users in Bangladesh. The Study reveals that there are significant gap between existing and expected perceived service network, 3G, customer care, physical facilities, billing cost, information service, mobile banking and GP offers. The study concludes that customer satisfaction is a dynamic phenomenon. Maintaining desired level of customer satisfaction requires corporate proactive responsiveness in accessing, building & retaining satisfied customers for sustainable competitive advantages in the marketplace.

  20. Principle of space existence and De Sitter metric

    International Nuclear Information System (INIS)

    Mal'tsev, V.K.

    1990-01-01

    The selection principle for the solutions of the Einstein equations suggested in a series of papers implies the existence of space (g ik ≠ 0) only in the presence of matter (T ik ≠0). This selection principle (principle of space existence, in the Markov terminology) implies, in the general case, the absence of the cosmological solution with the De Sitter metric. On the other hand, the De Sitter metric is necessary for describing both inflation and deflation periods of the Universe. It is shown that the De Sitter metric is also allowed by the selection principle under discussion if the metric experiences the evolution into the Friedmann metric

  1. [Does the right to die with dignity exist?].

    Science.gov (United States)

    Toro Flores, Rafael

    2008-12-01

    Death is one of the few certainties in human beings. This reality generates uneasiness regarding how death will occur especially in circumstances of loneliness or suffering which can become agony. In this report, the author first analyzes the existence of the right to die with dignity as a human right which takes on the nature of being a subjective right. In continuation, the author describes the existing problematic in the application of this right to die in relationship to the so-called double effect mechanism and euthanasia. The author concludes this article by proposing previous instructions or anticipated desires as ideal measures to make the right to die with dignity valid.

  2. On the existence of n-dimensional indecomposable vector bundles

    International Nuclear Information System (INIS)

    Tan Xiaojiang.

    1991-09-01

    Let X be an arbitrary smooth irreducible complex projective curve of genus g with g ≥ 4. In this paper we extend the existence theorem of special divisors to high dimensional indecomposable vector bundles. We give a necessary and sufficient condition on the existence of n-dimensional indecomposable vector bundles E with deg(E) = d, dimH 0 (X,E) ≥ h. We also determine under what condition the set of all such vector bundles will be finite and how many elements it contains. (author). 9 refs

  3. FMDP reactor alternative summary report. Volume 1 - existing LWR alternative

    International Nuclear Information System (INIS)

    Greene, S.R.; Bevard, B.B.

    1996-01-01

    Significant quantities of weapons-usable fissile materials [primarily plutonium and highly enriched uranium (HEU)] are becoming surplus to national defense needs in both the United States and Russia. These stocks of fissile materials pose significant dangers to national and international security. The dangers exist not only in the potential proliferation of nuclear weapons but also in the potential for environmental, safety, and health (ES ampersand H) consequences if surplus fissile materials are not properly managed. This document summarizes the results of analysis concerned with existing light water reactor plutonium disposition alternatives

  4. Existence of core localized toroidicity-induced Alfven eigenmode

    International Nuclear Information System (INIS)

    Fu, G.Y.

    1995-02-01

    The core-localized toroidicity-induced Alfven eigenmode (TAE) is shown to exist at finite plasma pressure due to finite aspect ratio effects in tokamak plasma. The new critical beta for the existence of the TAE mode is given by α∼ 3ε + 2s 2 , where ε = r/R is the inverse aspect ratio, s is the magnetic shear and α = -Rq 2 dβ/dr is the normalized pressure gradient. In contrast, previous critical α is given by α ∼ s 2 . In the limit of s << √r/R, the new critical α is greatly enhanced by the finite aspect ratio effects

  5. FMDP reactor alternative summary report. Volume 1 - existing LWR alternative

    Energy Technology Data Exchange (ETDEWEB)

    Greene, S.R.; Bevard, B.B. [and others

    1996-10-07

    Significant quantities of weapons-usable fissile materials [primarily plutonium and highly enriched uranium (HEU)] are becoming surplus to national defense needs in both the United States and Russia. These stocks of fissile materials pose significant dangers to national and international security. The dangers exist not only in the potential proliferation of nuclear weapons but also in the potential for environmental, safety, and health (ES&H) consequences if surplus fissile materials are not properly managed. This document summarizes the results of analysis concerned with existing light water reactor plutonium disposition alternatives.

  6. Managed care, consumerism, preventive medicine: does a causal connection exist?

    Science.gov (United States)

    Rizzo, John A; Xie, Yang

    2006-07-01

    Managed care plans, and HMOs in particular, have long touted that their emphasis is on preventive care, to avoid expensive illness later in life. However, few articles in the contemporary literature adequately address this claim. The available evidence seems to support that HMOs do, in fact, provide greater access to preventive services, but the limitations of this research are substantial. This article discusses the scientific evidence on the relationships between managed care arrangements and the implications for preventive care in the current era, emphasizing consumer choices and less-restrictive plan structures.

  7. Dementia ascertainment using existing data in UK longitudinal and cohort studies: a systematic review of methodology.

    Science.gov (United States)

    Sibbett, Ruth A; Russ, Tom C; Deary, Ian J; Starr, John M

    2017-07-03

    Studies investigating the risk factors for or causation of dementia must consider subjects prior to disease onset. To overcome the limitations of prospective studies and self-reported recall of information, the use of existing data is key. This review provides a narrative account of dementia ascertainment methods using sources of existing data. The literature search was performed using: MEDLINE, EMBASE, PsychInfo and Web of Science. Included articles reported a UK-based study of dementia in which cases were ascertained using existing data. Existing data included that which was routinely collected and that which was collected for previous research. After removing duplicates, abstracts were screened and the remaining articles were included for full-text review. A quality tool was used to evaluate the description of the ascertainment methodology. Of the 3545 abstracts screened, 360 articles were selected for full-text review. 47 articles were included for final consideration. Data sources for ascertainment included: death records, national datasets, research databases and hospital records among others. 36 articles used existing data alone for ascertainment, of which 27 used only a single data source. The most frequently used source was a research database. Quality scores ranged from 7/16 to 16/16. Quality scores were better for articles with dementia ascertainment as an outcome. Some papers performed validation studies of dementia ascertainment and most indicated that observed rates of dementia were lower than expected. We identified a lack of consistency in dementia ascertainment methodology using existing data. With no data source identified as a "gold-standard", we suggest the use of multiple sources. Where possible, studies should access records with evidence to confirm the diagnosis. Studies should also calculate the dementia ascertainment rate for the population being studied to enable a comparison with an expected rate.

  8. History of evidence-based medicine

    Directory of Open Access Journals (Sweden)

    Roger L Sur

    2011-01-01

    Full Text Available This essay reviews the historical circumstances surrounding the introduction and evolution of evidence-based medicine. Criticisms of the approach are also considered. Weaknesses of existing standards of clinical practice and efforts to bring more certainty to clinical decision making were the foundation for evidence-based medicine, which integrates epidemiology and medical research. Because of its utility in designing randomized clinical trials, assessing the quality of the literature, and applying medical research at the bedside, evidence-based medicine will continue to have a strong influence on everyday clinical practice.

  9. Evidence for the former existence of a thicker ice sheet on the Vestfjella nunataks in western Dronning Maud Land, Antarctica

    Directory of Open Access Journals (Sweden)

    Lintinen, P.

    1996-06-01

    Full Text Available Vestfjella (73-74°S, 13-16°W is a 130 km long nunatak range in western Dronning Maud Land in East Antarctica, and its northern and southern ends are situated close to the present ice sheet grounding-line. Striations and lodgement till on nunatak Basen indicate that the northernmost Vestfjella nunataks were formerly covered by a thicker Antarctic ice sheet. Striations on the summit ridge of nunatak Plogen indicate that the minimum change in ice thickness has been 700 m at the present ice sheet grounding-line. The relatively uniform oldest striation direction on different nunatak summits and the altitude of Plogen, which is less than 200 m lower than the highest Vestfjella summits, indicates that the whole of Vestfjella may have been covered by an ice sheet. Oxidation of till surface stones and an increased clay fraction in the upper part of the till layer were the only indications of soil formation on Basen. The unweathered nature of the Basen lodgement till indicate a relatively young age for deglaciation. This conclusion is also supported by age determinations and sedimentological data obtained from Weddell Sea sediments by Norwegian researchers, suggesting that a grounded ice sheet extended to the shelf edge at around 21 ka B.P. However the age of the glaciation which covered Basen and Plogen and the subsequent deglaciation is not based on precise dates and therefore the late Wisconsinan/Weichselian age is only a working hypothesis.

  10. Evidence against the existence of specific Schistosoma mansoni subpopulations which are resistant to irradiated vaccine-induced immunity

    International Nuclear Information System (INIS)

    Lewis, F.A.; Hieny, S.; Sher, A.

    1985-01-01

    When mice are immunized with irradiated Schistosoma mansoni cercariae a proportion of the subsequent cercarial challenge always escapes killing and matures to egg-laying adults. This report investigates the possibility that incomplete immunity in this system is governed by a genetically-determined insusceptibility of a particular schistosome subpopulation. To do this the authors tested whether more immunoresistant schistosomes would develop following successive passages of progeny of the resistant worms through immunized mice. Mice were immunized with 500 50 Krad-irradiated cercariae, and challenged with normal cercariae when immunity was at its peak. After five successive passages through snails and immune mice, progeny of those parasites which escaped immune killing were no more refractory to vaccine-induced resistance than the original stock maintained in nonimmune mice. Additionally, the passaged isolates did not differ from the original stock in their ability to induce protection following irradiation. The results indicate that with this model of acquired resistance incomplete immunity is unlikely to be due to a subpopulation of the parasites possessing a genetically-determined insusceptibility to killing

  11. Evidence for the existence of a tyrosyl residue in the nicotinamide adenine dinucleotide binding site of chicken liver xanthine dehydrogenase

    International Nuclear Information System (INIS)

    Nishino, T.; Nishino, T.

    1987-01-01

    Xanthine-NAD and NADH-methylene blue oxidoreductase activities of chicken liver xanthine dehydrogenase were inactivated by incubation with 5'-[p-(fluorosulfonyl)benzoyl]adenosine (5'-FSBA), an active site directed reagent for nucleotide binding sites. The inactivation reaction displayed pseudo-first-order kinetics. A double-reciprocal plot of inactivation velocity vs. 5'-FSBA concentration showed that 5'-FSBA and enzyme formed a complex prior to inactivation. NAD protected the enzyme from inactivation by 5'-FSBA in a competitive fashion. The modified enzyme had the same xanthine-dichlorophenolindophenol and xanthine-O 2 oxidoreductase activities as the native enzyme, and on addition of xanthine to the modified enzyme, bleaching of the spectrum occurred in the visible region. The amount of radioactivity incorporated into the enzyme by incubation with [ 14 C]-5'-FSBA was parallel to the loss of xanthine-NAD oxidoreductase activity, and the stoichiometry was 1 mol/mol of enzyme-bound FAD for complete inactivation. These results indicated that 5'-FSBA modified specifically the binding site for NAD of chicken liver xanthine dehydrogenase. The incorporated radioactivity was released slowly from 14 C-labeled enzyme by incubation with dithiothreitol with concomitant restoration of catalytic activity. The modified residue responsible for inactivation was identified as a tyrosine

  12. Evidence for Existence of Immunoglobulins that Block Ovarian Granulosa Cell Growth in Vitro. A Putative Role in Resistant Ovary Syndrome?

    NARCIS (Netherlands)

    WEISSENBRUCH, MIRJAM M. van; HOEK, ANNEMIEKE; VLIET-BLEEKER, INGRID van; SCHOEMAKER, JOOP; DREXHAGE, HEMMO

    1991-01-01

    The sera of 26 patients with premature ovarian failure were examined in order to detect immunoglobulin-G (IgGs) that can block FSH-induced in vitro granulosa cell DNA synthesis via, a Feulgen cytochemical bioassay system. The IgGs of four patients with polycystic ovary-like disease, five

  13. Phylogenetic Evidence for the Existence of Novel Thermophilic Bacteria in Hot Spring Sulfur-Turf Microbial Mats in Japan

    Science.gov (United States)

    Yamamoto, Hiroyuki; Hiraishi, Akira; Kato, Kenji; Chiura, Hiroshi X.; Maki, Yonosuke; Shimizu, Akira

    1998-01-01

    So-called sulfur-turf microbial mats, which are macroscopic white filaments or bundles consisting of large sausage-shaped bacteria and elemental sulfur particles, occur in sulfide-containing hot springs in Japan. However, no thermophiles from sulfur-turf mats have yet been isolated as cultivable strains. This study was undertaken to determine the phylogenetic positions of the sausage-shaped bacteria in sulfur-turf mats by direct cloning and sequencing of 16S rRNA genes amplified from the bulk DNAs of the mats. Common clones with 16S rDNA sequences with similarity levels of 94.8 to 99% were isolated from sulfur-turf mat samples from two geographically remote hot springs. Phylogenetic analysis showed that the phylotypes of the common clones formed a major cluster with members of the Aquifex-Hydrogenobacter complex, which represents the most deeply branching lineage of the domain bacteria. Furthermore, the bacteria of the sulfur-turf mat phylotypes formed a clade distinguishable from that of other members of the Aquifex-Hydrogenobacter complex at the order or subclass level. In situ hybridization with clone-specific probes for 16S rRNA revealed that the common phylotype of sulfur-turf mat bacteria is that of the predominant sausage-shaped bacteria. PMID:9572936

  14. Does the modified Stroop effect exist in PTSD? Evidence from dissertation abstracts and the peer reviewed literature.

    Science.gov (United States)

    Kimble, Matthew O; Frueh, B Christopher; Marks, Libby

    2009-06-01

    The modified Stroop effect (MSE), in which participants show delayed colour naming to trauma-specific words, is one of the most widely cited findings in the literature pertaining to cognitive bias in posttraumatic stress disorder (PTSD). The current study used a novel approach (Dissertation Abstract Review; DAR) to review the presence of the MSE in dissertation abstracts. A review of dissertations that used the modified Stroop task in a PTSD sample revealed that only 8% of the studies found delayed reaction times to trauma-specific words in participants with PTSD. The most common finding (75%) was for no PTSD-specific effects in colour naming trauma-relevant words. This ratio is significantly lower than ratios found in the peer reviewed literature, but even in the peer reviewed literature only 44% of controlled studies found the modified Stroop effect. These data suggest that a reevaluation of the MSE in PTSD is warranted.

  15. Does the modified Stroop effect exist in PTSD? Evidence from dissertation abstracts and the peer reviewed literature

    OpenAIRE

    Kimble, Matthew O.; Frueh, B. Christopher; Marks, Libby

    2009-01-01

    The modified Stroop effect (MSE), in which participants show delayed color naming to trauma specific words is one of the most widely cited findings in the literature pertaining to cognitive bias in posttraumatic stress disorder (PTSD). The current study used a novel approach (Dissertation Abstract Review; DAR) to review the presence of the MSE in dissertation abstracts. A review of dissertations that used the modified Stroop task in a PTSD sample revealed that only 8% of the studies found del...

  16. Decision-Making Process Related to Participation in Phase I Clinical Trials: A Nonsystematic Review of the Existing Evidence.

    Science.gov (United States)

    Gorini, Alessandra; Mazzocco, Ketti; Pravettoni, Gabriella

    2015-01-01

    Due to the lack of other treatment options, patient candidates for participation in phase I clinical trials are considered the most vulnerable, and many ethical concerns have emerged regarding the informed consent process used in the experimental design of such trials. Starting with these considerations, this nonsystematic review is aimed at analyzing the decision-making processes underlying patients' decision about whether to participate (or not) in phase I trials in order to clarify the cognitive and emotional aspects most strongly implicated in this decision. Considering that there is no uniform decision calculus and that many different variables other than the patient-physician relationship (including demographic, clinical, and personal characteristics) may influence patients' preferences for and processing of information, we conclude that patients' informed decision-making can be facilitated by creating a rigorously developed, calibrated, and validated computer tool modeled on each single patient's knowledge, values, and emotional and cognitive decisional skills. Such a tool will also help oncologists to provide tailored medical information that is useful to improve the shared decision-making process, thereby possibly increasing patient participation in clinical trials. © 2015 S. Karger AG, Basel.

  17. Edible fat structures at high solid fat concentrations: Evidence for the existence of oil-filled nanospaces

    Science.gov (United States)

    Peyronel, Fernanda; Quinn, Bonnie; Marangoni, Alejandro G.; Pink, David A.

    2015-01-01

    We have characterized the surfaces of grain boundaries in edible oils with high solid fat content by combining ultra-small angle x-ray scattering (USAXS) with theoretical modelling and computer simulation. Our results will lead to understand the solid structures formed at the time of manufacturing fats like confectionery fats as well as pave the way for the engineering of innovative fat products. Edible fats are complex semi-solid materials where a solid structure entraps liquid oil. It was not until USAXS combined with modelling was used that the nano- to meso-structures for systems with less than 20% solids were understood. The interpretation of those results utilized models of crystalline nanoplatelets represented by rigid close-packed flat aggregates made of spheres and was allowed to aggregate using the Metropolis Monte Carlo technique. Here, we report on systems containing between 50% and 90% solids. We modelled the solid phase as being formed from seeds onto which solids condensed thereby giving rise to oil-filled nanospaces. The models predicted that the system (a) exhibits structures with fractal dimensions approximately 2, (b) a broad peak somewhat masking that slope, and (c) for smaller values of q, indications that the structures with fractal dimension approximately 2 are uniformly distributed in space. The interpretation of the experimental data was completely driven by these results. The computer simulation predictions were used in conjunction with the USAXS observations to conclude that the systems studied scattered from oil-cavities with sizes between ˜800 and ˜16 000 Å and possessed rough 2-dimensional walls.

  18. Complex, multilayered azimuthal anisotropy beneath Tibet: evidence for co-existing channel flow and pure-shear crustal thickening

    Science.gov (United States)

    Agius, Matthew R.; Lebedev, Sergei

    2017-09-01

    Of the two debated, end-member models for the late-Cenozoic thickening of Tibetan crust, one invokes 'channel flow' (rapid viscous flow of the mid-lower crust, driven by topography-induced pressure gradients and transporting crustal rocks eastward) and the other 'pure shear' (faulting and folding in the upper crust, with viscous shortening in the mid-lower crust). Deep-crustal deformation implied by each model is different and would produce different anisotropic rock fabric. Observations of seismic anisotropy can thus offer a discriminant. We use broad-band phase-velocity curves-each a robust average of tens to hundreds of measurements-to determine azimuthal anisotropy in the entire lithosphere-asthenosphere depth range and constrain its amplitude. Inversions of the differential dispersion from path pairs, region-average inversions and phase-velocity tomography yield mutually consistent results, defining two highly anisotropic layers with different fast-propagation directions within each: the middle crust and the asthenosphere. In the asthenosphere beneath central and eastern Tibet, anisotropy is 2-4 per cent and has an NNE-SSW fast-propagation azimuth, indicating flow probably driven by the NNE-ward, shallow-angle subduction of India. The distribution and complexity of published shear wave splitting measurements can be accounted for by the different anisotropy in the mid-lower crust and asthenosphere. The estimated splitting times that would be accumulated in the crust alone are 0.25-0.8 s; in the upper mantle-0.5-1.2 s, depending on location. In the middle crust (20-45 km depth) beneath southern and central Tibet, azimuthal anisotropy is 3-5 and 4-6 per cent, respectively, and its E-W fast-propagation directions are parallel to the current extension at the surface. The rate of the extension is relatively low, however, whereas the large radial anisotropy observed in the middle crust requires strong alignment of mica crystals, implying large finite strain and consistent with high-rate horizontal flow. Together, radial and azimuthal anisotropy suggest eastward mid-crustal channel flow in central Tibet, along the regional topography gradient. In NE high Tibet, mid-crustal azimuthal anisotropy is 4-8 per cent and has WNW-ESE and NW-SE fast-propagation directions, parallel to the net extension at the surface. These fast directions are inconsistent with channel flow following the SW-NE regional topography gradient. Instead, they suggest similar net deformation in the (decoupled) shallow and deep crust. In the brittle upper crust, it is accommodated by strike-slip faulting; in the ductile mid-lower crust-by shear oriented at ∼45° to the faults. Although mid-crustal flow beneath NE Tibet may transport some material towards the plateau periphery at a low region-average rate, the dominant mid-crust deformation pattern is shear parallel to the plateau boundary. This implies that channel flow from central Tibet is not the main cause of the on-going crustal thickening farther northeast.

  19. Evidence for existence of functional monoclinic phase in sodium niobate based solid solution by powder neutron diffraction

    Science.gov (United States)

    Mishra, S. K.; Jauhari, Mrinal; Mittal, R.; Krishna, P. S. R.; Reddy, V. R.; Chaplot, S. L.

    2018-04-01

    We have carried out systematic temperature-dependent neutron diffraction measurements in conjunction with dielectric spectroscopy from 6 to 300 K for sodium niobate based compounds (1-x) NaNbO3-xBaTiO3 (NNBTx). The dielectric constant is measured as a function of both temperature and frequency. It shows an anomaly at different temperatures in cooling and heating cycles and exhibits a large thermal hysteresis of ˜150 K for the composition x = 0.03. The dielectric constant is found to be dispersive in nature and suggests a relaxor ferroelectric behavior. In order to explore structural changes as a function of temperature, we analyzed the powder neutron diffraction data for the compositions x = 0.03 and 0.05. Drastic changes are observed in the powder profiles near 2θ ˜ 30.6°, 32.1°, and 34.6° in the diffraction pattern below 200 K during cooling and above 190 K in heating cycles, respectively. The disappearance of superlattice reflection and splitting in main perovskite peaks provide a signature for structural phase transition. We observed stabilization of a monoclinic phase (Cc) at low temperature. This monoclinic phase is believed to provide a flexible polarization rotation and considered to be directly linked to the high performance piezoelectricity in materials. The thermal hysteresis for composition x = 0.03 is larger than that for x = 0.05. This suggests that the addition of BaTiO3 to NaNbO3 suppresses the thermal hysteresis. It is also observed that the structural phase transition temperature decreases upon increasing the dopant concentration.

  20. Evidence for the existence of multiple heparan sulfate proteoglycans in the human glomerular basement membrane and mesangial matrix

    NARCIS (Netherlands)

    Groffen, Alexander J A; Hop, Frank W H; Tryggvason, Karl; Dijkman, Henri; Assmann, Karel J M; Veerkamp, Jacques H.; Monnens, Leo A H; Van Den Heuvel, Lambert P W J

    1997-01-01

    Heparan sulfate proteoglycans (HSPGs) are essential components of the glomerular basement membrane (GBM) carrying a strong anionic charge. A well- characterized extracellular HSPG is perlecan, ubiquitously expressed in basement membranes. A cDNA construct encoding domains I and II of human perlecan

  1. Hydrogen–Hydrogen Bonding in Planar Biphenyl, Predicted by Atoms-In-Molecules Theory, Does Not Exist

    NARCIS (Netherlands)

    Poater, J; Sola, M.; Bickelhaupt, F.M.

    2006-01-01

    Based on an Atoms-in-Molecules (AIM) analysis, Matta et al. (Chem. Eur. J.2003, 9, 1940) recently claimed evidence for the existence of hydrogen–hydrogen bonding between ortho-hydrogen atoms, pointing towards each other from adjacent phenyl groups in planar biphenyl. This AIM result is opposed to

  2. Review and evaluation of the methodological quality of the existing guidelines and recommendations for inherited neurometabolic disorders

    DEFF Research Database (Denmark)

    Cassis, Linda; Cortès-Saladelafont, Elisenda; Molero-Luis, Marta

    2015-01-01

    and timely treatments are often pivotal for the favorable course of the disease. Thus, the elaboration of new evidence-based recommendations for iNMD diagnosis and management is increasingly requested by health care professionals and patients, even though the methodological quality of existing guidelines...

  3. Probabilistic risk assessment for new and existing chemicals: Example calculations

    NARCIS (Netherlands)

    Jager T; Hollander HA den; Janssen GB; Poel P van der; Rikken MGJ; Vermeire TG; ECO; CSR; LAE; CSR

    2000-01-01

    In the risk assessment methods for new and existing chemicals in the EU, "risk" is characterised by means of the deterministic quotient of exposure and effects (PEC/PNEC or Margin of Safety). From a scientific viewpoint, the uncertainty in the risk quotient should be accounted for explicitly in the

  4. 40 CFR 407.14 - Pretreatment standards for existing sources.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Pretreatment standards for existing sources. 407.14 Section 407.14 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED FRUITS AND VEGETABLES PROCESSING POINT SOURCE...

  5. 40 CFR 407.34 - Pretreatment standards for existing sources.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Pretreatment standards for existing sources. 407.34 Section 407.34 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED FRUITS AND VEGETABLES PROCESSING POINT SOURCE...

  6. 40 CFR 407.24 - Pretreatment standards for existing sources.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Pretreatment standards for existing sources. 407.24 Section 407.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED FRUITS AND VEGETABLES PROCESSING POINT SOURCE...

  7. 40 CFR 406.14 - Pretreatment standards for existing sources.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Pretreatment standards for existing sources. 406.14 Section 406.14 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GRAIN MILLS POINT SOURCE CATEGORY Corn Wet Milling Subcategory § 406.14...

  8. 40 CFR 406.24 - Pretreatment standards for existing sources.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Pretreatment standards for existing sources. 406.24 Section 406.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GRAIN MILLS POINT SOURCE CATEGORY Corn Dry Milling Subcategory § 406.24...

  9. Building OOC layers on top of existing courses

    DEFF Research Database (Denmark)

    Bang, Jørgen; Dalsgaard, Christian; Kjær, Arne

    2016-01-01

    prefer the term "Open Online Courses", MOOCs (Massive Open Online Courses) without the M. This paper will present our approach to building OOCs on top of existing campusbased courses at Aarhus University, Denmark. Consequently, participants of an 'OOC track' will engage in collaboration and discussions...

  10. 40 CFR 421.275 - Pretreatment standards for existing sources.

    Science.gov (United States)

    2010-07-01

    ... Nickel 0.000 0.000 (e) Sodium hypochlorite filter backwash. PSES for the Primary Rare Earth Metals...) EFFLUENT GUIDELINES AND STANDARDS NONFERROUS METALS MANUFACTURING POINT SOURCE CATEGORY Primary Rare Earth Metals Subcategory § 421.275 Pretreatment standards for existing sources. Except as provided in 40 CFR...

  11. A unifying approach to existence of Nash equilibria

    NARCIS (Netherlands)

    Balder, E.J.

    1997-01-01

    An approach initiated in [4] is shown to unify results about the existence of (i) Nash equilibria in games with at most countably many players, (ii) Cournot-Nash equilibrium distributions for large, anonymous games, and (iii) Nash equilibria (both mixed and pure) for continuum games. A new, central

  12. Priority setting for existing chemicals : automated data selection routine

    NARCIS (Netherlands)

    Haelst, A.G. van; Hansen, B.G.

    2000-01-01

    One of the four steps within Council Regulation 793/93/EEC on the evaluation and control of existing chemicals is the priority setting step. The priority setting step is concerned with selecting high-priority substances from a large number of substances, initially starting with 2,474

  13. Existence of Green's functions in perturbative Q.E.D

    International Nuclear Information System (INIS)

    Seneor, R.

    1976-01-01

    A report is made on some work done in collaboration with P. Blanchard which shows how, in the framework developped by H.Epstein and V.Glaser, one can prove the existence of Green's functions in quantum electrodynamics (Q.E.D.). The proof can be extended, in principle, to any theory involving massive and non massive particles. (Auth.)

  14. Existence of solutions of abstract fractional impulsive semilinear evolution equations

    Directory of Open Access Journals (Sweden)

    K. Balachandran

    2010-01-01

    Full Text Available In this paper we prove the existence of solutions of fractional impulsive semilinear evolution equations in Banach spaces. A nonlocal Cauchy problem is discussed for the evolution equations. The results are obtained using fractional calculus and fixed point theorems. An example is provided to illustrate the theory.

  15. Priors & prejudice : using existing knowledge in social science research

    NARCIS (Netherlands)

    Van Wesel, F.

    2011-01-01

    Researchers in the social sciences usually start their research with the formulation of research goals and questions, which, together with studying the existing literature, lead to the formulation of hypotheses. Next, data is collected using experiments or questionnaires and is subsequently

  16. Low energy house in existing buildings; Niedrigenergiehaus im Bestand

    Energy Technology Data Exchange (ETDEWEB)

    Sahner, G. [BDA, Stuttgart/Augsburg (Germany)

    2008-07-01

    Presented is an energetic sanitation of residential units in the frame of a German pilot program (''low energy houses in the existing building sector'') initiated by the ministry of traffic, civil engineering and city development. (GL)

  17. On existence and stability of solutions for higher order semilinear ...

    Indian Academy of Sciences (India)

    To be precise, we consider a primal action functional for which the Dirichlet problem is an Euler–Lagrange equation, later we define a suitable dual action functional and by introducing a duality theory we investigate relations between both action function- als. Our method is based on investigating the existence of a minimum ...

  18. Preretirement Programs within Service Firms: Existing and Planned Programs.

    Science.gov (United States)

    Siegel, Sidney R.; Rives, Janet M.

    1980-01-01

    A study of 300 nonmanufacturing firms' current and projected preretirement programs indicated that (1) personnel departments have primary responsibility for existing programs, (2) focus is changing from financial planning to psychological counseling, and (3) such programs benefit the company as well as the employee. (SK)

  19. 76 FR 9376 - Proposed Extension of Existing Information Collection;

    Science.gov (United States)

    2011-02-17

    ... Extension of Existing Information Collection; Refuse Piles and Impoundment Structures, Recordkeeping and... surface installations. More specifically, these sections address refuse piles (30 CFR 77.215), and... combination of materials; and refuse piles are deposits of coal mine waste (other than overburden or spoil...

  20. Existence and multiplicity results for homoclinic orbits of Hamiltonian systems

    Directory of Open Access Journals (Sweden)

    Chao-Nien Chen

    1997-03-01

    Full Text Available Homoclinic orbits play an important role in the study of qualitative behavior of dynamical systems. Such kinds of orbits have been studied since the time of Poincare. In this paper, we discuss how to use variational methods to study the existence of homoclinic orbits of Hamiltonian systems.

  1. On the existence of weak solutions of quantum stochastic differential ...

    African Journals Online (AJOL)

    We establish further results concerning the existence, uniqueness and stability of weak solutions of quantum stochastic differential equations (QSDEs). Our results are achieved by considering a more general Lipschit condition on the coefficients than our previous considerations in [1]. We exhibit a class of Lipschitzian ...

  2. Existence and Policy Effectiveness in Feedback Nash LQ-Games

    Directory of Open Access Journals (Sweden)

    Nicola Acocella

    2008-12-01

    Full Text Available This paper illustrates how the classical theory of economic policy can profitably be used to verify some properties of the Linear Nash Feedback Equilibrium in difference LQ-games. In particular, we find that both a necessary condition for the equilibrium existence and a sufficient condition for policy ineffectiveness can be defined in the terms of the simple Tinbergen counting rule.

  3. Existence of global attractor for the Trojan Y Chromosome model

    Directory of Open Access Journals (Sweden)

    Xiaopeng Zhao

    2012-04-01

    Full Text Available This paper is concerned with the long time behavior of solution for the equation derived by the Trojan Y Chromosome (TYC model with spatial spread. Based on the regularity estimates for the semigroups and the classical existence theorem of global attractors, we prove that this equations possesses a global attractor in $H^k(\\Omega^4$ $(k\\geq 0$ space.

  4. Why Choose Online Learning: Relationship of Existing Factors and Chronobiology

    Science.gov (United States)

    Luo, Yi; Pan, Rui; Choi, Jea H.; Mellish, Linda; Strobel, Johannes

    2011-01-01

    Existing research on choice of online learning utilized factors such as perceived level of control, independence, and satisfaction, yet the relationship among these factors is under-researched. Due to the value of "learning anytime," biological factors underlying "choice of time" might provide additional insights. This article…

  5. 49 CFR 1300.2 - Disclosure requirement for existing rates.

    Science.gov (United States)

    2010-10-01

    ..., PUBLICATION, AND NOTICE OF CHANGE OF RATES AND OTHER SERVICE TERMS FOR RAIL COMMON CARRIAGE § 1300.2 Disclosure requirement for existing rates. (a) A rail carrier must disclose to any person, upon formal... rail carrier under this section must be provided immediately. (It is expected that the response will be...

  6. The existence of solutions of q-difference-differential equations.

    Science.gov (United States)

    Wang, Xin-Li; Wang, Hua; Xu, Hong-Yan

    2016-01-01

    By using the Nevanlinna theory of value distribution, we investigate the existence of solutions of some types of non-linear q-difference differential equations. In particular, we generalize the Rellich-Wittich-type theorem and Malmquist-type theorem about differential equations to the case of q-difference differential equations (system).

  7. Man-machine enhancements to existing FFTF control panels

    International Nuclear Information System (INIS)

    Miller, E.M.

    1984-01-01

    FFTF Project enhanced existing control panels with tape and labels to mitigate operator problems and to incorporate the guidance of NUREG-0700. The enhancements grouped displays and controls into meaningful units and labelled controls and displays to facilitate their identification and efficient use. The enhancements were inexpensive and well received by the facility's operations staff

  8. On the Existence of Hydrogen Salts of Monoprotic Acids

    Science.gov (United States)

    Stojanovska, Marina I.; Petrusevski, Vladimir M.; Soptrajanov, Bojan T.

    2012-01-01

    The notion that acid salts exist only for diprotic and polyprotic acids is found in many high school and university textbooks, although the "only" condition is not always stated explicitly. A fairly simple experiment shows that there is a pronounced exothermic effect when pure acetic acid is added to potassium acetate. Experiments with similar…

  9. How to inject consumerism into your existing health plans.

    Science.gov (United States)

    Havlin, Linda J; McAllister, Michael F; Slavney, David H

    2003-09-01

    Consumerism seeks to create a behavior change on the part of consumers so that they become accountable, knowledgeable and actively engaged in managing their health. It can be used in any existing health plan through targeted plan design changes and consumer education efforts. Employers have many options in addition to consumer-directed health plans (CDHPs).

  10. Branding in children: a barbaric practice still exists in India

    Science.gov (United States)

    Patra, Pratap Kumar

    2016-01-01

    Branding is an inhuman traditional practice most commonly employed to treat various disorders in neonates and children in certain community in India. Though stringent law exists to prevent such harmful practices, cases of branding is not uncommon in current era. PMID:27217887

  11. Traditional Rational Arguments for the Existence of God (Chukwu) in ...

    African Journals Online (AJOL)

    Religion Dept

    wonder also man has turned his attention to all sorts of problems revolving around God, ranging from ... Consequently they are divided. Likewise, the God- ... memories of one's pilgrimage to God: ONUCHUKWU (God's voice or shrine of the ... also certain Igbo names which explicitly assert that God exists. Such names are ...

  12. Does neuroscience prove that free will does not exist?

    NARCIS (Netherlands)

    Evers, H.W.A.

    2012-01-01

    Dutch criminal and civil law agree that one cannot be convicted of a crime unless one is responsible for it. And it's natural to think that one cannot be responsible for an act unless one freely decided to do it. So if free will does not exist, this might have drastic consequences for our legal

  13. Inhibition of existing denitrification enzyme activity by chloramphenicol

    Science.gov (United States)

    Brooks, M.H.; Smith, R.L.; Macalady, D.L.

    1992-01-01

    Chloramphenicol completely inhibited the activity of existing denitrification enzymes in acetylene-block incubations with (i) sediments from a nitrate-contaminated aquifer and (ii) a continuous culture of denitrifying groundwater bacteria. Control flasks with no antibiotic produced significant amounts of nitrous oxide in the same time period. Amendment with chloramphenicol after nitrous oxide production had begun resulted in a significant decrease in the rate of nitrous oxide production. Chloramphenicol also decreased (>50%) the activity of existing denitrification enzymes in pure cultures of Pseudomonas denitrificans that were harvested during log- phase growth and maintained for 2 weeks in a starvation medium lacking electron donor. Short-term time courses of nitrate consumption and nitrous oxide production in the presence of acetylene with P. denitrificans undergoing carbon starvation were performed under optimal conditions designed to mimic denitrification enzyme activity assays used with soils. Time courses were linear for both chloramphenicol and control flasks, and rate estimates for the two treatments were significantly different at the 95% confidence level. Complete or partial inhibition of existing enzyme activity is not consistent with the current understanding of the mode of action of chloramphenicol or current practice, in which the compound is frequently employed to inhibit de novo protein synthesis during the course of microbial activity assays. The results of this study demonstrate that chloramphenicol amendment can inhibit the activity of existing denitrification enzymes and suggest that caution is needed in the design and interpretation of denitrification activity assays in which chloramphenicol is used to prevent new protein synthesis.

  14. Existence of solutions for second-order evolution inclusions

    Directory of Open Access Journals (Sweden)

    Nikolaos S. Papageorgiou

    1994-01-01

    Full Text Available In this paper we examine second-order nonlinear evolution inclusions and prove two existence theorems; one with a convex-valued orientor field and the other with a nonconvex-valued field. An example of a hyperbolic partial differential inclusion is also presented.

  15. DOES A LATIN-AMERICAN SECURITY COMMUNITY EXIST?

    Directory of Open Access Journals (Sweden)

    FRANCISCO S. BARROSO CORTÉS

    2017-09-01

    Similarly, the article points out the main characteristics that the Latin American security community would present, and the challenges and handicaps to overcome. To conclude, the article demonstrates how the integration process in this special field continues on, even though the existing context characterized by austerity and a low level of insecurity.

  16. Existence results for impulsive semilinear damped differential inclusions

    Directory of Open Access Journals (Sweden)

    Mouffak Benchohra

    2003-06-01

    Full Text Available In this paper we investigate the existence of mild solutions for first and second order impulsive semilinear evolution inclusions in separable Banach spaces. By using suitable fixed point theorems, we study the case when the multivalued map has convex and nonconvex values.

  17. Improvement Design of an Existing Atomized Kerosene Stove for ...

    African Journals Online (AJOL)

    The existing atomized kerosene stove being used in some households in Nigeria does not give room for primary air fuel mixture but secondary one before combustion. This in turn leads to higher specific fuel consumption and ultimately lower thermal efficiency (resulting from low combustion efficiency) of the stove. In order ...

  18. "Rabbit Proof Fence": A Struggle for Cultural Existence

    Science.gov (United States)

    Al-Momani, Hassan Ali Abdullah

    2016-01-01

    The main goal of this paper is to depict the struggle for cultural existence in "Rabbit Proof Fence." It also reflects the cultural conflict represented in the three aboriginal girls' characters which is due to their rejection and resistance for the colonialists' culture. Besides, the paper presents the cognitive analysis of the cultural…

  19. 12 CFR 410.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Program accessibility: Existing facilities. 410.150 Section 410.150 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY EXPORT-IMPORT BANK OF THE UNITED...

  20. 45 CFR 2490.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Program accessibility: Existing facilities. 2490.150 Section 2490.150 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON... ACTIVITIES CONDUCTED BY THE JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION § 2490.150 Program accessibility...

  1. Existence of extremal periodic solutions for quasilinear parabolic equations

    Directory of Open Access Journals (Sweden)

    Siegfried Carl

    1997-01-01

    bounded domain under periodic Dirichlet boundary conditions. Our main goal is to prove the existence of extremal solutions among all solutions lying in a sector formed by appropriately defined upper and lower solutions. The main tools used in the proof of our result are recently obtained abstract results on nonlinear evolution equations, comparison and truncation techniques and suitably constructed special testfunction.

  2. DNA to DNA transcription might exist in eukaryotic cells

    OpenAIRE

    Li, Gao-De

    2016-01-01

    Till now, in biological sciences, the term, transcription, mainly refers to DNA to RNA transcription. But our recently published experimental findings obtained from Plasmodium falciparum strongly suggest the existence of DNA to DNA transcription in the genome of eukaryotic cells, which could shed some light on the functions of certain noncoding DNA in the human and other eukaryotic genomes.

  3. Personnel shift assignment: Existence conditions and network models

    NARCIS (Netherlands)

    van den Berg, Jeroen P.; van den Berg, J.P.; Panton, David M.

    1994-01-01

    The personnel scheduling problem is known to be a five-stage process in which the final stage involves the assignment of shifts to the days worked in the schedule. This paper discusses the existence conditions for both continuous and forward rotating shift assignments and heuristic network

  4. Existence of Three Solutions for $p$-biharmonic Equation

    Directory of Open Access Journals (Sweden)

    Lin Li

    2011-10-01

    Full Text Available In this paper, the existence of at least three solutions to a Navier boundary problem involving the $p$-biharmonic equation, will be established. The technical approach is mainly based on the three critical points theorem of B. Ricceri.

  5. The existence of policies, practices and perceptions regarding ...

    African Journals Online (AJOL)

    Interviews were conducted with 7 nursing managers regarding the existence and content of a hospital visitors' policy, 12 operational managers (OMs) to describe ward practices regarding child visitors, and 12 professional nurses and 11 doctors to determine their attitudes towards children as visitors in all four general state ...

  6. Facilities improvement for sustainability of existing public office ...

    African Journals Online (AJOL)

    The study examined the building design features of a cosmopolitan public office building in Abuja. The features were classified into Spatial Plan, Structure and Facilities, to determine which of the 3 variables requires urgent sustainable improvement from end-users' perspective in existing public office buildings in developing ...

  7. Existence of Positive Solutions for Nonlinear Eigenvalue Problems

    Directory of Open Access Journals (Sweden)

    Fan-Kai Kung

    2010-01-01

    Full Text Available We use a fixed point theorem in a cone to obtain the existence of positive solutions of the differential equation, u″+λf(t,u=0, 0

  8. The application, benefits and challenges of retrofitting the existing buildings

    Science.gov (United States)

    Khairi, Muhammad; Jaapar, Aini; Yahya, Zaharah

    2017-11-01

    Sustainable development has been the main topic of debate for years in some countries such as United Kingdom, United State of America and Malaysia. Depletion of natural resources, global warming, economics uncertainty and health issues are some of the reasons behind sustainable development movements, it is not just a political debate in the parliament but more towards collective works among sectors in order to minimizing the negative impact of development to the environment and other living organism. Retrofit an existing building is one of the solutions to reduce the dependency on constructing new buildings. There are huge numbers of existing building stocks that suitable to be retrofitted such as historical buildings, offices, residential, warehouse, factories, vacant buildings and other historical buildings. Therefore, the aim of this research is to provide information on the application, benefits and challenges of retrofitting an existing building. Two buildings were chosen as case studies following by site visits and observation to the buildings. The data were then compared in a table form. Primary and secondary sources were also used for this research. The application of retrofit should be promoted across the construction and conservation industries since it has significant tangible and intangible benefits. It is one of the most environmentally friendly and efficient solutions to optimize the energy performance and could also helps to extend the life of the existing building or historical buildings while ensuring optimum thermal comfort for the occupants which leads to higher productivity.

  9. The amazing vitality of things that don’t exist

    DEFF Research Database (Denmark)

    Tarp, Sven

    2016-01-01

    This contribution moves in the grey zone between lexicographical reality and fiction. It starts three hundred years ago and presents some dictionaries that do not exist. It then follows the historical development and shows how these dictionaries recently have got company by lexicographical theories...

  10. Modelling the feasibility of retrofitting hydropower to existing South ...

    African Journals Online (AJOL)

    An investigation was carried out with the primary objective of ascertaining whether it is possible to develop a model for determining the feasibility of retrofitting hydropower to existing dams in South Africa. The need for such a model is primarily due to the growing importance of small-scale hydropower projects resulting from ...

  11. Using existing case-mix methods to fund trauma cases.

    Science.gov (United States)

    Monakova, Julia; Blais, Irene; Botz, Charles; Chechulin, Yuriy; Picciano, Gino; Basinski, Antoni

    2010-01-01

    Policymakers frequently face the need to increase funding in isolated and frequently heterogeneous (clinically and in terms of resource consumption) patient subpopulations. This article presents a methodologic solution for testing the appropriateness of using existing grouping and weighting methodologies for funding subsets of patients in the scenario where a case-mix approach is preferable to a flat-rate based payment system. Using as an example the subpopulation of trauma cases of Ontario lead trauma hospitals, the statistical techniques of linear and nonlinear regression models, regression trees, and spline models were applied to examine the fit of the existing case-mix groups and reference weights for the trauma cases. The analyses demonstrated that for funding Ontario trauma cases, the existing case-mix systems can form the basis for rational and equitable hospital funding, decreasing the need to develop a different grouper for this subset of patients. This study confirmed that Injury Severity Score is a poor predictor of costs for trauma patients. Although our analysis used the Canadian case-mix classification system and cost weights, the demonstrated concept of using existing case-mix systems to develop funding rates for specific subsets of patient populations may be applicable internationally.

  12. 49 CFR 28.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Program accessibility: Existing facilities. 28.150 Section 28.150 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION § 28...

  13. Quantifying expert consensus against the existence of a secret, large-scale atmospheric spraying program

    Science.gov (United States)

    Shearer, Christine; West, Mick; Caldeira, Ken; Davis, Steven J.

    2016-08-01

    Nearly 17% of people in an international survey said they believed the existence of a secret large-scale atmospheric program (SLAP) to be true or partly true. SLAP is commonly referred to as ‘chemtrails’ or ‘covert geoengineering’, and has led to a number of websites purported to show evidence of widespread chemical spraying linked to negative impacts on human health and the environment. To address these claims, we surveyed two groups of experts—atmospheric chemists with expertize in condensation trails and geochemists working on atmospheric deposition of dust and pollution—to scientifically evaluate for the first time the claims of SLAP theorists. Results show that 76 of the 77 scientists (98.7%) that took part in this study said they had not encountered evidence of a SLAP, and that the data cited as evidence could be explained through other factors, including well-understood physics and chemistry associated with aircraft contrails and atmospheric aerosols. Our goal is not to sway those already convinced that there is a secret, large-scale spraying program—who often reject counter-evidence as further proof of their theories—but rather to establish a source of objective science that can inform public discourse.

  14. Skeletal evidence for Inca warfare from the Cuzco region of Peru.

    Science.gov (United States)

    Andrushko, Valerie A; Torres, Elva C

    2011-11-01

    This article addresses the bioarchaeological evidence for Inca warfare through an analysis of 454 adult skeletons from 11 sites in the Inca capital region of Cuzco, Peru. These 11 sites span almost 1000 years (AD 600-1532), which allows for a comparison of the evidence for warfare before the Inca came to power (Middle Horizon AD 600-1000), during the time of Inca ascendency in the Late Intermediate Period (AD 1000-1400), and after the Inca came to power and expanded throughout the Cuzco region and beyond (Inca Imperial Period, AD 1400-1532). The results indicate that 100 of 454 adults (22.0%) showed evidence of cranial trauma. Of these, 23 individuals had major cranial injuries suggestive of warfare, consisting of large, complete, and/or perimortem fractures. There was scant evidence for major injuries during the Middle Horizon (2.8%, 1/36) and Late Intermediate Period (2.5%, 5/199), suggesting that warfare was not prevalent in the Cuzco region before and during the Inca rise to power. Only in the Inca Imperial Period was there a significant rise in major injuries suggestive of warfare (7.8%, 17/219). Despite the significant increase in Inca times, the evidence for major cranial injuries was only sporadically distributed at Cuzco periphery sites and was entirely absent at Cuzco core sites. These findings suggest that while the Inca used warfare as a mechanism for expansion in the Cuzco region, it was only one part of a complex expansion strategy that included economic, political, and ideological means to gain and maintain control. Copyright © 2011 Wiley-Liss, Inc.

  15. A Systematic Review of the Economic Evidence for Home Support Interventions in Dementia.

    Science.gov (United States)

    Clarkson, Paul; Davies, Linda; Jasper, Rowan; Loynes, Niklas; Challis, David

    2017-09-01

    Recent evidence signals the need for effective forms of home support to people with dementia and their carers. The cost-effectiveness evidence of different approaches to support is scant. To appraise economic evidence on the cost-effectiveness of home support interventions for dementia to inform future evaluation. A systematic literature review of full and partial economic evaluations was performed using the British National Health Service Economic Evaluation Database supplemented by additional references. Study characteristics and findings, including incremental cost-effectiveness ratios, when available, were summarized narratively. Study quality was appraised using the National Health Service Economic Evaluation Database critical appraisal criteria and independent ratings, agreed by two reviewers. Studies were located on a permutation matrix describing their mix of incremental costs/effects to aid decision making. Of the 151 articles retrieved, 14 studies met the inclusion criteria: 8 concerning support to people with dementia and 6 to carers. Five studies were incremental cost-utility analyses, seven were cost-effectiveness analyses, and two were cost consequences analyses. Five studies expressed incremental cost-effectiveness ratios as cost per quality-adjusted life-year (£6,696-£207,942 per quality-adjusted life-year). In four studies, interventions were dominant over usual care. Two interventions were more costly but more beneficial and were favorable against current acceptability thresholds. Occupational therapy, home-based exercise, and a carers' coping intervention emerged as cost-effective approaches for which there was better evidence. These interventions used environmental modifications, behavior management, physical activity, and emotional support as active components. More robust evidence is needed to judge the value of these and other interventions across the dementia care pathway. Copyright © 2017 International Society for Pharmacoeconomics and

  16. Justification, optimization and decision-aiding in existing exposure situations

    International Nuclear Information System (INIS)

    Hedemann-Jensen, Per

    2004-01-01

    The existing ICRP system of radiological protection from 1990 (ICRP Publication 60) can be seen as a binary or dual-line system dealing with protection in exposure situations categorized as either practices or interventions. The distinction between practices and interventions is summarized in the paper with focus on some of the problems experienced in making such a distinction. The protection principles within the existing system of protection are presented with emphasis on the application to de facto or existing exposure situations. Decision on countermeasures to mitigate the consequences of existing exposure situations such as nuclear or radiological accidents and naturally occurring exposure situations include factors or attributes describing benefits from the countermeasure and those describing harm. Some of these attributes are discussed and the general process of justification of intervention and optimization of protection arriving at generic reference levels for implementing protective measures is presented. In addition, the role of radiological protection professionals and other stakeholders in the decision-making process is discussed. Special attention is given to the question whether radiological protection should form only one of many decision-aiding inputs to a broader societal decision-making process or whether societal aspects should be fully integrated into the radiological protection framework. The concepts of practices and interventions, however logical they are, have created some confusion when applied to protection of the public following a nuclear or radiological accident. These problems may be solved in a new set of general ICRP recommendations on radiological protection, which are anticipated to supersede Publication 60 in 2005. The evolution of the basic ICRP principles for radiological protection in existing exposure situations into a new set of ICRP recommendations is briefly discussed based upon the various material that has been presented

  17. Semantic Modelling of Digital Forensic Evidence

    Science.gov (United States)

    Kahvedžić, Damir; Kechadi, Tahar

    The reporting of digital investigation results are traditionally carried out in prose and in a large investigation may require successive communication of findings between different parties. Popular forensic suites aid in the reporting process by storing provenance and positional data but do not automatically encode why the evidence is considered important. In this paper we introduce an evidence management methodology to encode the semantic information of evidence. A structured vocabulary of terms, ontology, is used to model the results in a logical and predefined manner. The descriptions are application independent and automatically organised. The encoded descriptions aim to help the investigation in the task of report writing and evidence communication and can be used in addition to existing evidence management techniques.

  18. Level of evidence gap in orthopedic research.

    Science.gov (United States)

    Baldwin, Keith D; Bernstein, Joseph; Ahn, Jaimo; McKay, Scott D; Sankar, Wudbhav N

    2012-09-01

    Level of evidence is the most widely used metric for the quality of a publication, but instances exist in which a Level I study is neither feasible nor desirable. The goal of this study was to evaluate the level of evidence gap in current orthopedic research, which the authors defined as the disparity between the level of evidence that would be required to optimally answer the primary research question and the level of evidence that was actually used. Five orthopedic surgeons (K.D.B., J.B., J.A., S.D.M., W.N.S.) evaluated blinded articles from the first 6 months of 2010 in the Journal of Bone and Joint Surgery (American Volume) (JBJS-Am), classifying the study type and design and extracting a primary research question from each article. Each evaluator then defined the study type and method, along with the level of evidence that would ideally be used to address the primary research question. The level of evidence gap was then calculated by subtracting the actual level of evidence of the manuscript from the level of evidence of the idealized study. Of the 64 JBJS-Am manuscripts eligible for analysis, the average level of evidence was between Level II and III (mean, 2.73). The average level of evidence gap was 1.06 compared with the JBJS-Am-designated level of evidence and 1.28 compared with the evaluators' assessment. Because not all questions require Level I studies, level of evidence alone may not be the best metric for the quality of orthopedic surgery literature. Instead, the authors' concept of a level of evidence gap may be a better tool for assessing the state of orthopedic research publications. Copyright 2012, SLACK Incorporated.

  19. Comparing evil solution from Sadra and Allame Tabatabaei,s point of view according to dependant and independant existence

    Directory of Open Access Journals (Sweden)

    Masoomeh Vahidi

    2015-09-01

    Full Text Available The problem of evil has been presented in logical and evidential forms and has managed to undermine religious doctrines, leading to serious criticisms against religious beliefs. The theists have attempted to solve the problem through different ways. One of these attempts made in Islamic philosophy is the argument against the problem of evil through explaining the connective and independent existences. According to Mulla Sadra, the objective solitary reality of every existent stems from the existence which includes two levels: the independent existence and the connective one. All of the connective existents are ultimately related to an independent existent that contains all the other levels of existence. The connective existence can be illustrated in two different ways:   According to the first picture, the connective existent has the same existence as the independent being, while based on the second presentation it has an independent and distinct existent. It is because every contingent being consists of two dimensions of essence and existence. Its existence stems from God and thus is connected to Him and has no independence, and its essence is the absolute nothingness.   Based on Sadra, the essence which emanates from the presence of connective existence, is the source of all evils in the universe. Since the essence is existing indirectly and due to the connective existence and has no form of existence by itself, the evils which can be described as the privation of good, all are derived from the essence and are regarded as nullity.   According to Allamah, the connective existents are the beings which are totally related and affiliated to the independent existent and are regarded as the manifestations and evidences of His existence. These beings are accompanied by privation, constraints and negation which are imagined through the concept of essence. In fact, it is the human mind which manages to imagine the connective existent as independent

  20. Comparing evil solution from Sadra and Allame Tabatabaei,s point of view according to dependant and independant existence

    Directory of Open Access Journals (Sweden)

    Jafar Shanazari

    2015-08-01

    Full Text Available The problem of evil has been presented in logical and evidential forms and has managed to undermine religious doctrines, leading to serious criticisms against religious beliefs. The theists have attempted to solve the problem through different ways. One of these attempts made in Islamic philosophy is the argument against the problem of evil through explaining the connective and independent existences. According to Mulla Sadra, the objective solitary reality of every existent stems from the existence which includes two levels: the independent existence and the connective one. All of the connective existents are ultimately related to an independent existent that contains all the other levels of existence. The connective existence can be illustrated in two different ways:   According to the first picture, the connective existent has the same existence as the independent being, while based on the second presentation it has an independent and distinct existent. It is because every contingent being consists of two dimensions of essence and existence. Its existence stems from God and thus is connected to Him and has no independence, and its essence is the absolute nothingness.   Based on Sadra, the essence which emanates from the presence of connective existence, is the source of all evils in the universe. Since the essence is existing indirectly and due to the connective existence and has no form of existence by itself, the evils which can be described as the privation of good, all are derived from the essence and are regarded as nullity.   According to Allamah, the connective existents are the beings which are totally related and affiliated to the independent existent and are regarded as the manifestations and evidences of His existence. These beings are accompanied by privation, constraints and negation which are imagined through the concept of essence. In fact, it is the human mind which manages to imagine the connective existent as independent

  1. Solar potential in existing urban layouts—Critical overview of the existing building stock in Slovenian context

    International Nuclear Information System (INIS)

    Košir, Mitja; Capeluto, Isaac Guedi; Krainer, Aleš; Kristl, Živa

    2014-01-01

    In recent years implementation of sustainable building design in the EU has become one of the key issues in reducing energy dependence. In this context efficient use of solar potential incident on building envelope is essential. The goal of the study is to evaluate the influence of interventions required by the new Slovenian legislation and to propose general site planning guidelines. Special emphasis is devoted to the existing building stock, which is due for refurbishment. The study is carried out on the basis of seven typical urban layouts, which are assessed according to the shape of layout, density, building orientation and design. The calculations are carried out with the program SHADING. The study showed that the existing layouts are not as problematic as had been expected and that form and orientation of buildings present a major challenge. Nevertheless, the quality and the duration of insolation are highly dependent on the specifics of each case. The study showed that by respecting the basic rules of good practice in conjunction with the existing requirements no major changes in the existing design principles are needed. - Highlights: • New Slovenian legislation regarding minimum insolation of building envelope. • Seven typical urban layouts were analysed. • Requirements and rules of good practice result in adequate insolation. • Duration of insolation is highly dependent on the specifics of each case

  2. Energy Efficiency in the North American Existing Building Stock

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the findings of a new assessment of the techno-economic and policy-related efficiency improvement potential in the North American building stock conducted as part of a wider appraisal of existing buildings in member states of the International Energy Agency. It summarizes results and provides insights into the lessons learned through a broader global review of best practice to improve the energy efficiency of existing buildings. At this time, the report is limited to the USA because of the large size of its buildings market. At a later date, a more complete review may include some details about policies and programs in Canada. If resources are available an additional comprehensive review of Canada and Mexico may be performed in the future.

  3. On the problem of existence of quantum field theory

    International Nuclear Information System (INIS)

    Chaichian, M.; Hayashi, M.; Nelipa, N.F.; Pukhov, E.A.

    1978-01-01

    Existence of quantum field theory is considered for the four-dimensional phi 3 -model. The mathematical tool of contraction mapping principle is used to investigate the question of existence of solution for the infinite system of coupled equations for the Green functions of the theory in the Euclidean region. Formulation of the problem for this model with one divergent part is interesting in itself and provides the first attempt towards the study of other renormalizable quantum field theory models with infinite number of divergent graphs. For sufficiently small values of coupling constant, the theory has a unique solution for the truncated system of equations for the Green functions. However, for the complete, infinite set of equations, the Banach fixed point theorem admits a solution only when the coupling constant tends to zero. Possible reasons for such a result are discussed. (author)

  4. Analyzing the security of an existing computer system

    Science.gov (United States)

    Bishop, M.

    1986-01-01

    Most work concerning secure computer systems has dealt with the design, verification, and implementation of provably secure computer systems, or has explored ways of making existing computer systems more secure. The problem of locating security holes in existing systems has received considerably less attention; methods generally rely on thought experiments as a critical step in the procedure. The difficulty is that such experiments require that a large amount of information be available in a format that makes correlating the details of various programs straightforward. This paper describes a method of providing such a basis for the thought experiment by writing a special manual for parts of the operating system, system programs, and library subroutines.

  5. Existence and equivalence of twisted products on a symplectic manifold

    International Nuclear Information System (INIS)

    Lichnerowicz, A.

    1979-01-01

    The twisted products play an important role in Quantum Mechanics. A distinction is introduced between Vey *sub(γ) products and strong Vey *sub(γ) products and it is proved that each *sub(γ) product is equivalent to a Vey *sub(γ) product. If b 3 (W) = 0, the symplectic manifold (W,F) admits strong Vey *sub(Gn) products. If b 2 (W) = 0, all *sub(γ) products are equivalent as well as the Vey Lie algebras. In the general case the formal Lie algebras are characterized which are generated by a *sub(γ) product and it proved that the existance of a *sub(γ)-product is equivalent to the existance of a formal Lie algebra infinitesimally equivalent to a Vey Lie algebra at the first order. (Auth.)

  6. Existence of evolutionary variational solutions via the calculus of variations

    Science.gov (United States)

    Bögelein, Verena; Duzaar, Frank; Marcellini, Paolo

    In this paper we introduce a purely variational approach to time dependent problems, yielding the existence of global parabolic minimizers, that is ∫0T ∫Ω [uṡ∂tφ+f(x,Du)] dx dt⩽∫0T ∫Ω f(x,Du+Dφ) dx dt, whenever T>0 and φ∈C0∞(Ω×(0,T),RN). For the integrand f:Ω×R→[0,∞] we merely assume convexity with respect to the gradient variable and coercivity. These evolutionary variational solutions are obtained as limits of maps depending on space and time minimizing certain convex variational functionals. In the simplest situation, with some growth conditions on f, the method provides the existence of global weak solutions to Cauchy-Dirichlet problems of parabolic systems of the type ∂tu-divDξf(x,Du)=0 in Ω×(0,∞).

  7. Existence of traveling waves for diffusive-dispersive conservation laws

    Directory of Open Access Journals (Sweden)

    Cezar I. Kondo

    2013-02-01

    Full Text Available In this work we show the existence existence and uniqueness of traveling waves for diffusive-dispersive conservation laws with flux function in $C^{1}(mathbb{R}$, by using phase plane analysis. Also we estimate the domain of attraction of the equilibrium point attractor corresponding to the right-hand state. The equilibrium point corresponding to the left-hand state is a saddle point. According to the phase portrait close to the saddle point, there are exactly two semi-orbits of the system. We establish that only one semi-orbit come in the domain of attraction and converges to $(u_{-},0$ as $yo -infty$. This provides the desired saddle-attractor connection.

  8. Existing Noise Level at Railway Stations in Malaysia

    Directory of Open Access Journals (Sweden)

    Shahidan Shahiron

    2017-01-01

    Full Text Available Railway transportation known as one of the most environmental friendly transportation mode. However, the significance problems of railway transportation are noise pollution and negatively impact the wellbeing of the whole community. Unfortunately, there has been lack of public awareness about the noise level produce by the railway transportation in Malaysia. This study investigates the noise level produced by railway transportation in Malaysia specifically by Keretapi Tanah Melayu Berhad (KTMB. Methods of collecting existing noise level at railway stations in Malaysia are briefly discussed in this study. The finding indicates that the noise level produced by the railway transportation in Malaysia which is by KTMB is considered as dangerous to human being and also exceed the noise limit that has been assigned by Department of Environment Ministry of Natural Resources and Environment of Malaysia. A better noise barrier and improved material should be developed to mitigate the existing noise level produced by railway transportations in Malaysia.

  9. Regulatory Approaches for Adding Capacity to Existing Hydropower Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Levine, Aaron L. [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Curtis, Taylor L. [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Kazerooni, Borna [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-10-24

    In 2015, hydroelectric generation accounted for more than 6 percent of total net electricity generation in the United States and 46 percent of electricity generation from all renewables. The United States has considerable hydroelectric potential beyond what is already being developed. Nearly 7 GW of this potential is found by adding capacity to existing hydropower facilities. To optimize the value of hydroelectric generation, the U.S. Department of Energy's Hydropower Vision Study highlights the importance of adding capacity to existing facilities. This report provides strategic approaches and considerations for Federal Energy Regulatory Commission licensed and exempt hydropower facilities seeking to increase generation capacity, which may include increases from efficiency upgrades. The regulatory approaches reviewed for this report include capacity and non-capacity amendments, adding capacity during relicensing, and adding capacity when converting a license to a 10-MW exemption.

  10. Guidance for closure of existing DOE LLW disposal sites

    International Nuclear Information System (INIS)

    Blanchfield, L.

    1987-01-01

    During FY 1986, a closure guidance document was developed. The purpose of this document is to provide guidance in support of DOE Order 5820.2 to site operating contractors for the stabilization and closure of existing low-level waste (LLW) shallow land disposal sites at US Department of Energy (DOE) facilities. Guidance is provided to aid operators in placing existing LLW sites in a closed conditions, i.e., a condition in which a nonoperational site meets postclosure performance requirements and can be shown, within a high degree of confidence, to perform as anticipated in the future, under the most cost-effective maintenance approach. Guidance is based on the philosophy that closure should be planned and performed using a systems approach. Plans for FY 1987 call for revision of the document to incorporate more information on closure of LLW sites also containing radioactive mixed waste and/or transuranic waste. 4 references, 3 figures, 2 tables

  11. Gamma Ray Bursts as Cosmological Probes with EXIST

    Science.gov (United States)

    Hartmann, Dieter; EXIST Team

    2006-12-01

    The EXIST mission, studied as a Black Hole Finder Probe within NASA's Beyond Einstein Program, would, in its current design, trigger on 1000 Gamma Ray Bursts (GRBs) per year (Grindlay et al, this meeting). The redshift distribution of these GRBs, using results from Swift as a guide, would probe the z > 7 epoch at an event rate of > 50 per year. These bursts trace early cosmic star formation history, point to a first generation of stellar objects that reionize the universe, and provide bright beacons for absorption line studies with groundand space-based observatories. We discuss how EXIST, in conjunction with other space missions and future large survey programs such as LSST, can be utilized to advance our understanding of cosmic chemical evolution, the structure and evolution of the baryonic cosmic web, and the formation of stars in low metallicity environments.

  12. On channel selection and shape co-existence

    International Nuclear Information System (INIS)

    Dracoulis, G.D.

    1993-08-01

    Ambivalence with respect to a favoured shape is emerging as a ubiquitous phenomenon in nuclei. Multiple minima in the nuclear potential well occur because of the delicate balance in nuclei between the long and short-range properties of the nuclear force and the contribution specific particle orbitals make in forcing the nucleus to a decision. Exploration of the dependence of the resulting shape co-existence on particle number and orbital is a prominent area of research. Experimental aspects of spectroscopy studies using heavy ion fusion, evaporation reactions and channel selection are discussed, with focus on shape co-existence in the light Os-Pt-Hg-Pb region. 42 refs., 8 figs

  13. Introduction of the EISA-PC into existing fusion experiments

    International Nuclear Information System (INIS)

    Tenten, W.; Bertschinger, G.; Mueller, K.D.; Reinhart, P.; Rongen, F.

    1995-01-01

    A general problem in the data acquisition field in fusion research is the lack of sufficient local memory for the storage of information acquired during a single discharge. While it is absolutely necessary to keep these data locally before transferring them to a central node, there has been a steadily increasing demand for more capacity. The introduction of an EISA-Personal-Computer with its vast and cheap memory resources is presenting a very interesting solution for the upgrade of existing installations and the design of new experiments. An innovative PC interface using Programmable Logic techniques was developed that allows easy and fast integration of a PC into an existing experimental setup. Several typical applications of this method are presented, that are of special interest for fusion experiments. (orig.)

  14. Planning Annuaulised hours when spike in demand exists

    Directory of Open Access Journals (Sweden)

    MR Sureshkumar

    2012-04-01

    Full Text Available Manpower planning using annualised hours is an effective tool where seasonal demand for staff in industry exists. In annualised hours (AH workers are contracted to work for a certain number of hours per year. The workers are associated with relative efficiency for different types of tasks. This paper proposes a Mixed Integer linear Programming (MILP model to solve an annualised working hours planning problem when spike in demand exists. The holiday weeks for the workers are considered as partially individualised. If a worker has been assigned with more than one type of working week in a week, this will be compensated with one or more holiday week. The performance of the model is demonstrated with an example. It can be seen that this type of modelling helps to meet the spikes in demand with less capacity shortage compared with one working week in a week.

  15. Percolation Model for the Existence of a Mitochondrial Eve

    CERN Document Server

    Neves, A G M

    2005-01-01

    We look at the process of inheritance of mitochondrial DNA as a percolation model on trees equivalent to the Galton-Watson process. The model is exactly solvable for its percolation threshold $p_c$ and percolation probability critical exponent. In the approximation of small percolation probability, and assuming limited progeny number, we are also able to find the maximum and minimum percolation probabilities over all probability distributions for the progeny number constrained to a given $p_c$. As a consequence, we can relate existence of a mitochondrial Eve to quantitative knowledge about demographic evolution of early mankind. In particular, we show that a mitochondrial Eve may exist even in an exponentially growing population, provided that the average number of children per individual is constrained to a small range depending on the probability $p$ that a newborn child is a female.

  16. Existence of conformal metrics on spheres with prescribed Paneitz curvature

    International Nuclear Information System (INIS)

    Ben Ayed, Mohamed; El Mehdi, Khalil

    2003-07-01

    In this paper we study the problem of prescribing a fourth order conformal invariant (the Paneitz curvature) on the n-spheres, with n ≥ 5. Using tools from the theory of critical points at infinity, we provide some topological conditions on the level sets of a given function defined on the sphere, under which we prove the existence of conformal metric with prescribed Paneitz curvature. (author)

  17. Condition of the existence of cooling flow in galaxies

    International Nuclear Information System (INIS)

    Volkov, E.V.

    1986-01-01

    A criterion for the existence of subsonic spherical symmetrical flow of cooling gas in galaxies has been found. Some equations are given describing the behaviour of gas in the gravitational field of a galaxy in the framework of a stationary accretion model. The results of numerical calculations of a nonstationary accretion of gas on a cD galaxy are presented. The gas is initially in a hydrostatic equilibrium

  18. Methodology for safety evaluation of existing timber elements

    OpenAIRE

    Sousa, Hélder S.

    2013-01-01

    Tese de doutoramento em Engenharia Civil The past decades have seen a renewed interest in timber research related topics. As instance, timber engineering is not only confined to the design of new construction with innovative wood based products, but also an increasing awareness for the preservation of existing timber structures is visible in nowadays society. Therefore, arises the need for a better understanding of timber performance as a construction material aiming at a bette...

  19. Existence of black holes due to concentration of angular momentum

    Energy Technology Data Exchange (ETDEWEB)

    Khuri, Marcus A. [Department of Mathematics, Stony Brook University,Stony Brook, NY 11794 (United States)

    2015-06-29

    We present a general sufficient condition for the formation of black holes due to concentration of angular momentum. This is expressed in the form of a universal inequality, relating the size and angular momentum of bodies, and is proven in the context of axisymmetric initial data sets for the Einstein equations which satisfy an appropriate energy condition. A brief comparison is also made with more traditional black hole existence criteria based on concentration of mass.

  20. Runaway pacemaker: a still existing complication and therapeutic guidelines

    DEFF Research Database (Denmark)

    Mickley, H; Andersen, C; Nielsen, L H

    1989-01-01

    Runaway pacemaker is a rare, but still existing potential lethal complication in permanent pacemakers. Within 4 1/2 years, we saw two cases of runaway pacemaker in patients with multiprogrammable, VVI pacemakers (Siemens-Elema, Model 668). In both cases a pacemaker-induced ventricular tachycardia...... pacemaker may be connected to the permanent pacing lead. Thereafter, the lead can be safely cut. As an alternative, a temporary transvenous pacing lead may be established prior to disconnecting the permanent pacing lead....

  1. Identifying the Onset of Congestion Rapidly with Existing Traffic Detectors

    OpenAIRE

    Coifman, Benjamin

    1999-01-01

    From an operations standpoint, the most important task of a traffic surveillance system is determining reliably whether the facility is free flowing or congested. The second most important task is responding rapidly when the facility becomes congested. Other tasks, such as quantifying the magnitude of congestion, are desirable, but tertiary. To address the first two tasks, this paper presents a new approach for traffic surveillance using existing detectors. Rather than expending a considerabl...

  2. Existence and multiplicity of solutions for nonlinear discrete inclusions

    Directory of Open Access Journals (Sweden)

    Nicu Marcu

    2012-11-01

    Full Text Available A non-smooth abstract result is used for proving the existence of at least one nontrivial solution of an algebraic discrete inclusion. Successively, a multiplicity theorem for the same class of discrete problems is also established by using a locally Lipschitz continuous version of the famous Brezis-Nirenberg theoretical result in presence of splitting. Some applications to tridiagonal, fourth-order and partial difference inclusions are pointed out.

  3. Existence of conformal metrics on spheres with prescribed Paneitz curvature

    CERN Document Server

    Ben-Ayed, M

    2003-01-01

    In this paper we study the problem of prescribing a fourth order conformal invariant (the Paneitz curvature) on the n-spheres, with n >= 5. Using tools from the theory of critical points at infinity, we provide some topological conditions on the level sets of a given function defined on the sphere, under which we prove the existence of conformal metric with prescribed Paneitz curvature.

  4. Existence of a coupled system of fractional differential equations

    International Nuclear Information System (INIS)

    Ibrahim, Rabha W.; Siri, Zailan

    2015-01-01

    We manage the existence and uniqueness of a fractional coupled system containing Schrödinger equations. Such a system appears in quantum mechanics. We confirm that the fractional system under consideration admits a global solution in appropriate functional spaces. The solution is shown to be unique. The method is based on analytic technique of the fixed point theory. The fractional differential operator is considered from the virtue of the Riemann-Liouville differential operator

  5. Business-as-Unusual: Existing policies in energy model baselines

    International Nuclear Information System (INIS)

    Strachan, Neil

    2011-01-01

    Baselines are generally accepted as a key input assumption in long-term energy modelling, but energy models have traditionally been poor on identifying baselines assumptions. Notably, transparency on the current policy content of model baselines is now especially critical as long-term climate mitigation policies have been underway for a number of years. This paper argues that the range of existing energy and emissions policies are an integral part of any long-term baseline, and hence already represent a 'with-policy' baseline, termed here a Business-as-Unusual (BAuU). Crucially, existing energy policies are not a sunk effort; as impacts of existing policy initiatives are targeted at future years, they may be revised through iterative policy making, and their quantitative effectiveness requires ex-post verification. To assess the long-term role of existing policies in energy modelling, currently identified UK policies are explicitly stripped out of the UK MARKAL Elastic Demand (MED) optimisation energy system model, to generate a BAuU (with-policy) and a REF (without policy) baseline. In terms of long-term mitigation costs, policy-baseline assumptions are comparable to another key exogenous modelling assumption - that of global fossil fuel prices. Therefore, best practice in energy modelling would be to have both a no-policy reference baseline, and a current policy reference baseline (BAuU). At a minimum, energy modelling studies should have a transparent assessment of the current policy contained within the baseline. Clearly identifying and comparing policy-baseline assumptions are required for cost effective and objective policy making, otherwise energy models will underestimate the true cost of long-term emissions reductions.

  6. Global existence result for the generalized Peterlin viscoelastic model

    Czech Academy of Sciences Publication Activity Database

    Lukáčová-Medviďová, M.; Mizerová, H.; Nečasová, Šárka; Renardy, M.

    2017-01-01

    Roč. 49, č. 4 (2017), s. 2950-2964 ISSN 0036-1410 R&D Projects: GA ČR GA13-00522S Institutional support: RVO:67985840 Keywords : Peterlin viscoelastic equations * global existence * weak solutions Subject RIV: BA - General Mathematics OBOR OECD: Pure mathematics Impact factor: 1.648, year: 2016 http://epubs.siam.org/doi/abs/10.1137/16M1068505

  7. Existence and multiplicity of solutions for divergence type elliptic equations

    Directory of Open Access Journals (Sweden)

    Lin Zhao

    2011-03-01

    Full Text Available We establish the existence and multiplicity of weak solutions of a problem involving a uniformly convex elliptic operator in divergence form. We find one nontrivial solution by the mountain pass lemma, when the nonlinearity has a $(p-1$-superlinear growth at infinity, and two nontrivial solutions by minimization and mountain pass when the nonlinear term has a $(p-1$-sublinear growth at infinity.

  8. Location of existing Case Studies on Open Education

    OpenAIRE

    Burke, Siobhan

    2014-01-01

    Members of the Open Education Special Interest Group have collected a selection of short case studies on Open Education. View all of the case studies at http://repository.alt.ac.uk/view/divisions/CaseStudies/ Location of existing Case Studies on Open Education: The following lists aims to capture and amalgamate the various different case study sources which have been created and developed within the UK around experiences of Open Educational Resources.

  9. Does a causal relation between cardiovascular disease and periodontitis exist?

    DEFF Research Database (Denmark)

    Belstrøm, Daniel; Damgaard, Christian; Nielsen, Claus H

    2012-01-01

    Inflammation is believed to play a central part in the pathogenesis of atherosclerosis, and much attention has been paid to the possible association between atherosclerosis and other inflammatory diseases. Periodontal disease is a common inflammatory disease affecting up to 50% of the adult...... population, and during the past two decades much research has focused on a possible association between periodontitis and cardiovascular disease. Here, we review the existing literature on the association between the two diseases....

  10. The Existence and Application of Unbounded Connected Components

    Directory of Open Access Journals (Sweden)

    Hua Luo

    2014-01-01

    Full Text Available Let X be a Banach space and Cn a family of connected subsets of R×X. We prove the existence of unbounded components in superior limit of {Cn}, denoted by lim¯ Cn, which have prescribed shapes. As applications, we investigate the global behavior of the set of positive periodic solutions to nonlinear first-order differential equations with delay, which can be used for modeling physiological processes.

  11. Existence of weak solutions to stochastic evolution inclusions

    OpenAIRE

    Jakubowski , Adam; Kamenskii , Mikhail; Raynaud de Fitte , Paul

    2005-01-01

    International audience; We consider the Cauchy problem for a semilinear stochastic differential inclusion in a Hilbert space. The linear operator generates a strongly continuous semigroup and the nonlinear term is multivalued and satisfies a condition which is more heneral than the Lipschitz condition. We prove the existence of a mild solution to this problem. This solution is not "strong" in the probabilistic sense, that is, it is not defined on the underlying probability space, but on a lar...

  12. Existence of a coupled system of fractional differential equations

    Energy Technology Data Exchange (ETDEWEB)

    Ibrahim, Rabha W. [Multimedia unit, Department of Computer System and Technology Faculty of Computer Science & IT, University of Malaya, 50603 Kuala Lumpur (Malaysia); Siri, Zailan [Institute of Mathematical Sciences, University of Malaya, 50603 Kuala Lumpur (Malaysia)

    2015-10-22

    We manage the existence and uniqueness of a fractional coupled system containing Schrödinger equations. Such a system appears in quantum mechanics. We confirm that the fractional system under consideration admits a global solution in appropriate functional spaces. The solution is shown to be unique. The method is based on analytic technique of the fixed point theory. The fractional differential operator is considered from the virtue of the Riemann-Liouville differential operator.

  13. Structural behaviour characterization of existing adobe constructions in Aveiro

    OpenAIRE

    Varum, H.; Costa, A.; Martins, T.; Pereira, H.; Almeida, J.; Rodrigues, H.; Silveira, D.

    2007-01-01

    Adobe was a widely used construction material in Aveiro, Portugal, till the middle of the 20th century. Nowadays, adobe can still be found in varied types of constructions, many of which are of cultural, historical, and also architectural recognized value. The existing adobe buildings present an important level of structural damage and, in many cases, are even near to ruin, having the majority a high vulnerability to seismic actions. To face the lack of information concerning the mechanica...

  14. Existence of Glass Ceiling in Public Universities of Lahore (Pakistan)

    OpenAIRE

    Asifa Ilyas

    2014-01-01

    Glass ceiling is a set of unseen factors which adversely affect females upward career growth and prevent them to get to top positions. This study is meant to explore existence of glass ceiling in public universities of Lahore (Pakistan); and factors responsible for creating this glass ceiling effect. The respondents of this study are females heading different departments in their respective universities. The results of this study show that different cultural and social, family and organizatio...

  15. Life cycle assessment: Existing building retrofit versus replacement

    Science.gov (United States)

    Darabi, Nura

    The embodied energy in building materials constitutes a large part of the total energy required for any building (Thormark 2001, 429). In working to make buildings more energy efficient this needs to be considered. Integrating considerations about life cycle assessment for buildings and materials is one promising way to reduce the amount of energy consumption being used within the building sector and the environmental impacts associated with that energy. A life cycle assessment (LCA) model can be utilized to help evaluate the embodied energy in building materials in comparison to the buildings operational energy. This thesis takes into consideration the potential life cycle reductions in energy and CO2 emissions that can be made through an energy retrofit of an existing building verses demolition and replacement with a new energy efficient building. A 95,000 square foot institutional building built in the 1960`s was used as a case study for a building LCA, along with a calibrated energy model of the existing building created as part of a previous Masters of Building Science thesis. The chosen case study building was compared to 10 possible improvement options of either energy retrofit or replacement of the existing building with a higher energy performing building in order to see the life cycle relationship between embodied energy, operational energy, and C02 emissions. As a result of completing the LCA, it is shown under which scenarios building retrofit saves more energy over the lifespan of the building than replacement with new construction. It was calculated that energy retrofit of the chosen existing institutional building would reduce the amount of energy and C02 emissions associated with that building over its life span.

  16. Existence of equilibria in quantum Bertrand-Edgeworth duopoly game

    Science.gov (United States)

    Sekiguchi, Yohei; Sakahara, Kiri; Sato, Takashi

    2012-12-01

    Both classical and quantum version of two models of price competition in duopoly market, the one is realistic and the other is idealized, are investigated. The pure strategy Nash equilibria of the realistic model exists under stricter condition than that of the idealized one in the classical form game. This is the problem known as Edgeworth paradox in economics. In the quantum form game, however, the former converges to the latter as the measure of entanglement goes to infinity.

  17. Concrete structures. Contribution to the safety assessment of existing structures

    Directory of Open Access Journals (Sweden)

    D. COUTO

    Full Text Available The safety evaluation of an existing concrete structure differs from the design of new structures. The partial safety factors for actions and resistances adopted in the design phase consider uncertainties and inaccuracies related to the building processes of structures, variability of materials strength and numerical approximations of the calculation and design processes. However, when analyzing a finished structure, a large number of unknown factors during the design stage are already defined and can be measured, which justifies a change in the increasing factors of the actions or reduction factors of resistances. Therefore, it is understood that safety assessment in existing structures is more complex than introducing security when designing a new structure, because it requires inspection, testing, analysis and careful diagnose. Strong knowledge and security concepts in structural engineering are needed, as well as knowledge about the materials of construction employed, in order to identify, control and properly consider the variability of actions and resistances in the structure. With the intention of discussing this topic considered complex and diffuse, this paper presents an introduction to the safety of concrete structures, a synthesis of the recommended procedures by Brazilian standards and another codes, associated with the topic, as well a realistic example of the safety assessment of an existing structure.

  18. Shared probe design and existing microarray reanalysis using PICKY

    Directory of Open Access Journals (Sweden)

    Chou Hui-Hsien

    2010-04-01

    Full Text Available Abstract Background Large genomes contain families of highly similar genes that cannot be individually identified by microarray probes. This limitation is due to thermodynamic restrictions and cannot be resolved by any computational method. Since gene annotations are updated more frequently than microarrays, another common issue facing microarray users is that existing microarrays must be routinely reanalyzed to determine probes that are still useful with respect to the updated annotations. Results PICKY 2.0 can design shared probes for sets of genes that cannot be individually identified using unique probes. PICKY 2.0 uses novel algorithms to track sharable regions among genes and to strictly distinguish them from other highly similar but nontarget regions during thermodynamic comparisons. Therefore, PICKY does not sacrifice the quality of shared probes when choosing them. The latest PICKY 2.1 includes the new capability to reanalyze existing microarray probes against updated gene sets to determine probes that are still valid to use. In addition, more precise nonlinear salt effect estimates and other improvements are added, making PICKY 2.1 more versatile to microarray users. Conclusions Shared probes allow expressed gene family members to be detected; this capability is generally more desirable than not knowing anything about these genes. Shared probes also enable the design of cross-genome microarrays, which facilitate multiple species identification in environmental samples. The new nonlinear salt effect calculation significantly increases the precision of probes at a lower buffer salt concentration, and the probe reanalysis function improves existing microarray result interpretations.

  19. On the existence of perturbed Robertson-Walker universes

    International Nuclear Information System (INIS)

    D'Eath, P.D.

    1976-01-01

    Solutions of the full nonlinear field equations of general relativity near the Robertson-Walker universes are examined, together with their relation to linearized perturbations. A method due to Choquet-Bruhat and Deser is used to prove existence theorems for solutions near Robertson-Walker constraint data of the constraint equations on a spacelike hypersurface. These theorems allow one to regard the matter fluctuations as independent quantities, ranging over certain function spaces. In the k=-1 case the existence theory describes perturbations which may vary within uniform bounds throughout space. When k=+1 a modification of the method leads to a theorem which clarifies some unusual features of these constraint perturbations. The k=0 existence theorem refers only to perturbations which die away at large distances. The connection between linearized constraint solutions and solutions of the full constraints is discussed. For k= +- 1 backgrounds, solutions of the linearized constraints are analyzed using transverse-traceless decompositions of symmetric tensors. Finally the time-evolution of perturbed constraint data and the validity of linearized perturbation theory for Robertson-Walker universes are considered

  20. Expansion potential for existing nuclear power station sites

    Energy Technology Data Exchange (ETDEWEB)

    Cope, D. F.; Bauman, H. F.

    1977-09-26

    This report is a preliminary analysis of the expansion potential of the existing nuclear power sites, in particular their potential for development into nuclear energy centers (NECs) of 10 (GW(e) or greater. The analysis is based primarily on matching the most important physical characteristics of a site against the dominating site criteria. Sites reviewed consist mainly of those in the 1974 through 1976 ERDA Nuclear Power Stations listings without regard to the present status of reactor construction plans. Also a small number of potential NEC sites that are not associated with existing power stations were reviewed. Each site was categorized in terms of its potential as: a dispersed site of 5 GW(e) or less; a mini-NEC of 5 to 10 GW(e); NECs of 10 to 20 GW(e); and large NECs of more than 20 GW(e). The sites were categorized on their ultimate potential without regard to political considerations that might restrain their development. The analysis indicates that nearly 40 percent of existing sites have potential for expansion to nuclear energy centers.

  1. Existence domain of electrostatic solitary waves in the lunar wake

    Science.gov (United States)

    Rubia, R.; Singh, S. V.; Lakhina, G. S.

    2018-03-01

    Electrostatic solitary waves (ESWs) and double layers are explored in a four-component plasma consisting of hot protons, hot heavier ions (He++), electron beam, and suprathermal electrons having κ-distribution using the Sagdeev pseudopotential method. Three modes exist: slow and fast ion-acoustic modes and electron-acoustic mode. The occurrence of ESWs and their existence domain as a function of various plasma parameters, such as the number densities of ions and electron beam, the spectral index, κ, the electron beam velocity, the temperatures of ions, and electron beam, are analyzed. It is observed that both the slow and fast ion-acoustic modes support both positive and negative potential solitons as well as their coexistence. Further, they support a "forbidden gap," the region in which the soliton ceases to propagate. In addition, slow ion-acoustic solitons support the existence of both positive and negative potential double layers. The electron-acoustic mode is only found to support negative potential solitons for parameters relevant to the lunar wake plasma. Fast Fourier transform of a soliton electric field produces a broadband frequency spectrum. It is suggested that all three soliton types taken together can provide a good explanation for the observed electrostatic waves in the lunar wake.

  2. Hanford Site background: Evaluation of existing soil radionuclide data

    International Nuclear Information System (INIS)

    1995-07-01

    This report is an evaluation of the existing data on radiological background for soils in the vicinity of the Hanford Site. The primary purpose of this report is to assess the adequacy of the existing data to serve as a radiological background baseline for use in environmental restoration and remediation activities at the Hanford Site. The soil background data compiled and evaluated in this report were collected by the Pacific Northwest Laboratory (PNL) and Washington State Department of Health (DOH) radiation surveillance programs in southeastern Washington. These two programs provide the largest well-documented, quantitative data sets available to evaluate background conditions at the Hanford Site. The data quality objectives (DQOs) considered in this evaluation include the amount of data, number of sampling localities, spatial coverage, number and types of radionuclides reported, frequency of reporting, documentation and traceability of sampling and laboratory methods used, and comparability between sets of data. Although other data on soil radionuclide abundances around the Hanford Site exist, they are generally limited in scope and lack the DQOs necessary for consideration with the PNL and DOH data sets. Collectively, these two sources provide data on the activities of 25 radionuclides and four other parameters (gross alpha, gross beta, total uranium, and total thorium). These measurements were made on samples from the upper 2.5 cm of soil at over 70 localities within the region

  3. Empirical Analysis on The Existence of The Phillips Curve

    Directory of Open Access Journals (Sweden)

    Shaari Mohd Shahidan

    2018-01-01

    Full Text Available The Phillips curve shows the trade-off relationship between the inflation and unemployment rates. A rise in inflation due to the high economic growth, more jobs are available and therefore unemployment will fall. However, the existence of the Phillips curve in high-income countries has not been much discussed. Countries with high income should have low unemployment rate, suggesting a high inflation. However, some high-income countries, the United States in 1970s for example, could not avert stagflation whereby high unemployment rate and inflation occurred in the same time. This situation is contrary to the Phillips curve. Therefore, this study aims to investigate the existence of the Phillips curve in high-income countries for the period 1990-2014 using the panel data analysis. The most interesting finding of this study is the existence of a bidirectional relationship between unemployment rate and inflation rate in both long and short runs. Therefore, the governments should choose to stabilize inflation rate or reduce unemployment rate

  4. A strategic approach for existing buildings to withstand climate change

    DEFF Research Database (Denmark)

    Rasmussen, Torben Valdbjørn

    2012-01-01

    Buildings play a vital economic and social role in society and are vulnerable to climate change. This paper suggests a strategic approach for existing buildings to withstand climate change. It emphasises the most likely climate impacts, including the change in mean year values as well as the exte...... based on the results of a vulnerability analysis. In addition, this paper describes some issues that must be addressed in case a strategic approach is not developed, as the building sector is continuously investing in measures to adapt to climate change.......Buildings play a vital economic and social role in society and are vulnerable to climate change. This paper suggests a strategic approach for existing buildings to withstand climate change. It emphasises the most likely climate impacts, including the change in mean year values as well as the extent......, the uncertainty of the scenarios leaves major challenges that will grow far more serious, if not addressed and taken into account in building design and into a strategy for the adaptation of existing buildings. An outline of the actions needed for developing a broad strategic approach to the adaptation to climate...

  5. Reserves in load capacity assessment of existing bridges

    Science.gov (United States)

    Žitný, Jan; Ryjáček, Pavel

    2017-09-01

    High percentage of all railway bridges in the Czech Republic is made of structural steel. Majority of these bridges is designed according to historical codes and according to the deterioration, they have to be assessed if they satisfy the needs of modern railway traffic. The load capacity assessment of existing bridges according to Eurocodes is however often too conservative and especially, braking and acceleration forces cause huge problems to structural elements of the bridge superstructure. The aim of this paper is to review the different approaches for the determination of braking and acceleration forces. Both, current and historical theoretical models and in-situ measurements are considered. The research of several local European state norms superior to Eurocode for assessment of existing railway bridges shows the big diversity of used local approaches and the conservativeness of Eurocode. This paper should also work as an overview for designers dealing with load capacity assessment, revealing the reserves for existing bridges. Based on these different approaches, theoretical models and data obtained from the measurements, the method for determination of braking and acceleration forces on the basis of real traffic data should be proposed.

  6. Expansion potential for existing nuclear power station sites

    International Nuclear Information System (INIS)

    Cope, D.F.; Bauman, H.F.

    1977-01-01

    This report is a preliminary analysis of the expansion potential of the existing nuclear power sites, in particular their potential for development into nuclear energy centers (NECs) of 10 (GW(e) or greater. The analysis is based primarily on matching the most important physical characteristics of a site against the dominating site criteria. Sites reviewed consist mainly of those in the 1974 through 1976 ERDA Nuclear Power Stations listings without regard to the present status of reactor construction plans. Also a small number of potential NEC sites that are not associated with existing power stations were reviewed. Each site was categorized in terms of its potential as: a dispersed site of 5 GW(e) or less; a mini-NEC of 5 to 10 GW(e); NECs of 10 to 20 GW(e); and large NECs of more than 20 GW(e). The sites were categorized on their ultimate potential without regard to political considerations that might restrain their development. The analysis indicates that nearly 40 percent of existing sites have potential for expansion to nuclear energy centers

  7. Possible existence of wormholes in the galactic halo region

    Energy Technology Data Exchange (ETDEWEB)

    Rahaman, Farook [Jadavpur University, Department of Mathematics, Kolkata, West Bengal (India); Kuhfittig, P.K.F. [Milwaukee School of Engineering, Department of Mathematics, Milwaukee, WI (United States); Ray, Saibal [Government College of Engineering and Ceramic Technology, Department of Physics, Kolkata, West Bengal (India); Islam, Nasarul [Danga High Madrasah, Department of Mathematics, Kolkata, West Bengal (India)

    2014-02-15

    Two observational results, the density profile from simulations performed in the ΛCDM scenario and the observed flat galactic rotation curves, are taken as input with the aim of showing that the galactic halo possesses some of the characteristics needed to support traversable wormholes. This result should be sufficient to provide an incentive for scientists to seek observational evidence for wormholes in the galactic halo region. (orig.)

  8. Business Groups Exist in Developed Markets Also: Britain Since 1850

    OpenAIRE

    Jones, Geoffrey G.

    2016-01-01

    Diversified business groups are well-known phenomenon in emerging markets, both today and historically. This is often explained by the prevalence of institutional voids or the nature of government-business relations. It is typically assumed that such groups were much less common in developed economies, and largely disappeared during the twentieth century. This working paper contests this assumption with evidence from Britain between 1850 and the present day. During the nineteenth century merc...

  9. Estimation of marginal costs at existing waste treatment facilities.

    Science.gov (United States)

    Martinez-Sanchez, Veronica; Hulgaard, Tore; Hindsgaul, Claus; Riber, Christian; Kamuk, Bettina; Astrup, Thomas F

    2016-04-01

    This investigation aims at providing an improved basis for assessing economic consequences of alternative Solid Waste Management (SWM) strategies for existing waste facilities. A bottom-up methodology was developed to determine marginal costs in existing facilities due to changes in the SWM system, based on the determination of average costs in such waste facilities as function of key facility and waste compositional parameters. The applicability of the method was demonstrated through a case study including two existing Waste-to-Energy (WtE) facilities, one with co-generation of heat and power (CHP) and another with only power generation (Power), affected by diversion strategies of five waste fractions (fibres, plastic, metals, organics and glass), named "target fractions". The study assumed three possible responses to waste diversion in the WtE facilities: (i) biomass was added to maintain a constant thermal load, (ii) Refused-Derived-Fuel (RDF) was included to maintain a constant thermal load, or (iii) no reaction occurred resulting in a reduced waste throughput without full utilization of the facility capacity. Results demonstrated that marginal costs of diversion from WtE were up to eleven times larger than average costs and dependent on the response in the WtE plant. Marginal cost of diversion were between 39 and 287 € Mg(-1) target fraction when biomass was added in a CHP (from 34 to 303 € Mg(-1) target fraction in the only Power case), between -2 and 300 € Mg(-1) target fraction when RDF was added in a CHP (from -2 to 294 € Mg(-1) target fraction in the only Power case) and between 40 and 303 € Mg(-1) target fraction when no reaction happened in a CHP (from 35 to 296 € Mg(-1) target fraction in the only Power case). Although average costs at WtE facilities were highly influenced by energy selling prices, marginal costs were not (provided a response was initiated at the WtE to keep constant the utilized thermal capacity). Failing to systematically

  10. Evidence Aid: Using Systematic Reviews to Improve Access to Evidence for Humanitarian Emergencies

    Directory of Open Access Journals (Sweden)

    Mike Clarke

    2017-10-01

    Full Text Available Evidence Aid is an international initiative to improve access to reliable evidence that will help people and organisations make well-informed decisions about interventions, actions and strategies in the disaster setting. It focuses on systematic reviews as the most reliable source of research evidence, maximising the power of existing research, avoiding undue emphasis on single studies and reducing the waste associated with research that is ignored or not accessible to decision makers. Evidence Aid is knowledge champion for influencers of the humanitarian sector, including funders, policy makers, NGOs, and humanitarian professionals. Evidence Aid was established by members of the Cochrane Collaboration after the Indian Ocean tsunami of December 2004. It provides access to information relevant to disaster risk reduction, planning, response, recovery, resilience and rehabilitation. This presentation will discuss the need for Evidence Aid, and describes its activities.Find out more about Mike.

  11. A knowledge transfer scheme to bridge the gap between science and practice: an integration of existing research frameworks into a tool for practice.

    Science.gov (United States)

    Verhagen, Evert; Voogt, Nelly; Bruinsma, Anja; Finch, Caroline F

    2014-04-01

    Evidence of effectiveness does not equal successful implementation. To progress the field, practical tools are needed to bridge the gap between research and practice and to truly unite effectiveness and implementation evidence. This paper describes the Knowledge Transfer Scheme integrating existing implementation research frameworks into a tool which has been developed specifically to bridge the gap between knowledge derived from research on the one side and evidence-based usable information and tools for practice on the other.

  12. A review of school nutrition interventions globally as an evidence ...

    African Journals Online (AJOL)

    NP Steyn, EV Lambert, W Parker, Z Mchiza, A De Villiers ... theory of behaviour, such as social cognitive, social marketing or stages of change. ... Consequently, it is necessary to plan programmes based on existing evidence of best practice.

  13. Synthesis of Evidence for Tobacco Taxation Policy Reform in West ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Existing evidence shows that tobacco taxation policies, when they make tobacco ... annual conference of McGill's Institute for the Study of International Development. ... In this ROSSA bulletin: Meet Kathryn Toure, the new regional director of ...

  14. Existence and non-existence for the full thermomechanical Souza–Auricchio model of shape memory wires

    Czech Academy of Sciences Publication Activity Database

    Krejčí, Pavel; Stefanelli, U.

    2011-01-01

    Roč. 16, č. 4 (2011), s. 349-365 ISSN 1081-2865 R&D Projects: GA ČR GAP201/10/2315 Institutional research plan: CEZ:AV0Z10190503 Keywords : shape memory alloys * thermomechanics * existence result * blowup in finite time Subject RIV: BA - General Mathematics Impact factor: 1.012, year: 2011 http://mms.sagepub.com/content/early/2011/03/11/1081286510386935.abstract

  15. Existence and non-existence for the full thermomechanical Souza–Auricchio model of shape memory wires

    Czech Academy of Sciences Publication Activity Database

    Krejčí, Pavel; Stefanelli, U.

    2011-01-01

    Roč. 16, č. 4 (2011), s. 349-365 ISSN 1081-2865 R&D Projects: GA ČR GAP201/10/2315 Institutional research plan: CEZ:AV0Z10190503 Keywords : shape memory alloys * thermomechanics * existence result * blowup in finite time Subject RIV: BA - General Mathematics Impact factor: 1.012, year: 2011 http:// mms .sagepub.com/content/early/2011/03/11/1081286510386935.abstract

  16. Common pitfalls in statistical analysis: "No evidence of effect" versus "evidence of no effect"

    Directory of Open Access Journals (Sweden)

    Priya Ranganathan

    2015-01-01

    Full Text Available This article is the first in a series exploring common pitfalls in statistical analysis in biomedical research. The power of a clinical trial is the ability to find a difference between treatments, where such a difference exists. At the end of the study, the lack of difference between treatments does not mean that the treatments can be considered equivalent. The distinction between "no evidence of effect" and "evidence of no effect" needs to be understood.

  17. Cost of enlarged operating zone for an existing Francis runner

    Science.gov (United States)

    Monette, Christine; Marmont, Hugues; Chamberland-Lauzon, Joël; Skagerstrand, Anders; Coutu, André; Carlevi, Jens

    2016-11-01

    Traditionally, hydro power plants have been operated close to best efficiency point, the more stable operating condition for which they have been designed. However, because of changes in the electricity market, many hydro power plants operators wish to operate their machines differently to fulfil those new market needs. New operating conditions can include whole range operation, many start/stops, extensive low load operation, synchronous condenser mode and power/frequency regulation. Many of these new operating conditions may impose more severe fatigue damage than the traditional base load operation close to best efficiency point. Under these conditions, the fatigue life of the runner may be significantly reduced and reparation or replacement cost might occur sooner than expected. In order to design reliable Francis runners for those new challenging operating scenarios, Andritz Hydro has developed various proprietary tools and design rules. These are used within Andritz Hydro to design mechanically robust Francis runners for the operating scenarios fulfilling customer's specifications. To estimate residual life under different operating scenarios of an existing runner designed years ago for best efficiency base load operation, Andritz Hydro's design rules and tools would necessarily lead to conservative results. While the geometry of a new runner can be modified to fulfil all conservative mechanical design rules, the predicted fatigue life of an existing runner under off-design operating conditions may appear rather short because of the conservative safety factor included in the calculations. The most precise and reliable way to calculate residual life of an existing runner under different operating scenarios is to perform a strain gauge measurement campaign on the runner. This paper presents the runner strain gage measurement campaign of a mid-head Francis turbine over all the operating conditions available during the test, the analysis of the measurement signals

  18. Risking existence: The experience and handling of depression.

    Science.gov (United States)

    Bygstad-Landro, Marte; Giske, Tove

    2018-02-01

    To gain insight into how people suffering from depression experience and manage life. Depression is the leading cause of incapacitation and constitutes the second largest healthcare burden worldwide, causing considerable discomfort for depression sufferers and their significant others. Depression must be understood against the backdrop of a person's context as well as biological, psychological and social factors. While various studies have been conducted on the process of depression, only a few studies have examined its existential aspects. A classical grounded theory methodology employing open and selective coding was used to identify the participants' main concern and the strategies they used to handle it. Data were collected in 2015-2016 during 18 in-depth interviews with people with current or former moderate depression. The data were analysed through constant comparisons until the grounded theory emerged. The main concern of the participants was Longing for belonging, and they handled their depression through a process named Risking existence. The process comprised four phases: (i) Ungraspable processing; (ii) Giving clues; (iii) Daring dependence; and (iv) Courage to be. The process of risking existence was accompanied from beginning to end by three essentials: to hope, to endure and shame. Working in mental health care involves encountering the pain, suffering and despair that humans endure. This challenges nurses to go beyond the symptoms and to listen for their meaning to each individual person. The grounded theory of risking existence provides a model by which nurses can orient themselves when working with people who are depressed. Each phase describes different strategies that patients use that can help the nurse recognise what is going on, thus enabling him or her to understand and guide his or her patients. © 2017 John Wiley & Sons Ltd.

  19. Viability of Existing INL Facilities for Dry Storage Cask Handling

    Energy Technology Data Exchange (ETDEWEB)

    Bohachek, Randy; Wallace, Bruce; Winston, Phil; Marschman, Steve

    2013-04-30

    This report evaluates existing capabilities at the INL to determine if a practical and cost effective method could be developed for opening and handling full-sized dry storage casks. The Idaho Nuclear Technology and Engineering Center (INTEC) CPP-603, Irradiated Spent Fuel Storage Facility, provides the infrastructure to support handling and examining casks and their contents. Based on a reasonable set of assumptions, it is possible to receive, open, inspect, remove samples, close, and reseal large bolted-lid dry storage casks at the INL. The capability can also be used to open and inspect casks that were last examined at the TAN Hot Shop over ten years ago. The Castor V/21 and REA-2023 casks can provide additional confirmatory information regarding the extended performance of low-burnup (<45 GWD/MTU) used nuclear fuel. Once a dry storage cask is opened inside CPP-603, used fuel retrieved from the cask can be packaged in a shipping cask, and sent to a laboratory for testing. Testing at the INL’s Materials and Fuels Complex (MFC) can occur starting with shipment of samples from CPP-603 over an on-site road, avoiding the need to use public highways. This reduces cost and reduces the risk to the public. The full suite of characterization methods needed to establish the condition of the fuel exists and MFC. Many other testing capabilities also exist at MFC, but when those capabilities are not adequate, samples can be prepared and shipped to other laboratories for testing. This report discusses how the casks would be handled, what work needs to be done to ready the facilities/capabilities, and what the work will cost.

  20. Viability of Existing INL Facilities for Dry Storage Cask Handling

    Energy Technology Data Exchange (ETDEWEB)

    Randy Bohachek; Charles Park; Bruce Wallace; Phil Winston; Steve Marschman

    2013-04-01

    This report evaluates existing capabilities at the INL to determine if a practical and cost effective method could be developed for opening and handling full-sized dry storage casks. The Idaho Nuclear Technology and Engineering Center (INTEC) CPP-603, Irradiated Spent Fuel Storage Facility, provides the infrastructure to support handling and examining casks and their contents. Based on a reasonable set of assumptions, it is possible to receive, open, inspect, remove samples, close, and reseal large bolted-lid dry storage casks at the INL. The capability can also be used to open and inspect casks that were last examined at the TAN Hot Shop over ten years ago. The Castor V/21 and REA-2023 casks can provide additional confirmatory information regarding the extended performance of low-burnup (<45 GWD/MTU) used nuclear fuel. Once a dry storage cask is opened inside CPP-603, used fuel retrieved from the cask can be packaged in a shipping cask, and sent to a laboratory for testing. Testing at the INL’s Materials and Fuels Complex (MFC) can occur starting with shipment of samples from CPP-603 over an on-site road, avoiding the need to use public highways. This reduces cost and reduces the risk to the public. The full suite of characterization methods needed to establish the condition of the fuel exists and MFC. Many other testing capabilities also exist at MFC, but when those capabilities are not adequate, samples can be prepared and shipped to other laboratories for testing. This report discusses how the casks would be handled, what work needs to be done to ready the facilities/capabilities, and what the work will cost.