WorldWideScience

Sample records for sber dat jejich

  1. Technostress, wat is dat?

    NARCIS (Netherlands)

    Eerenbeemt, J. van den

    2018-01-01

    Technostress, dat is toch dat oudere mensen in de stress raken van nieuwe software? Deze reactie hoorden we voortdurend van deelnemers aan ons TNO-onderzoek. We weten namelijk niet wat technostress is, waar het door komt en of we er last van hebben. Vakmedianet

  2. CM(dat) Seminarer 2003

    DEFF Research Database (Denmark)

    Denne publikation indeholder en samling af artikler som skrevet af Cand. Merc.(dat.) studerende på deres 3. semester i forbindelse med linieseminar i datalogi i efteråret 2003. Opgaver som de studerende har løst har været at skrive en teoretisk oversigtsartikel inden for et selvvalgt emne. Formål...

  3. Importance of Direct Antiglobulin Test (DAT in Cord Blood: Causes of DAT (+ in a Cohort Study

    Directory of Open Access Journals (Sweden)

    Serena Valsami

    2015-08-01

    Conclusions: Although ABO incompatibility remains the main reason of DAT (+, other causes (e.g., alloimmunization, drugs should also be explored. The relevant impact of DAT (+ on HDN development should be considered.

  4. CADAQUES: Metodika pro komplexní řízení kvality dat a informací

    Directory of Open Access Journals (Sweden)

    David

    2014-06-01

    Full Text Available Dnešní doba je charakteristická stále se zvětšujícím množstvím pořizovaných a zpracovávaných dat. Cílem tohoto článku je poukázat na různorodost současně používaných datových zdrojů, ukázat jejich specifika z pohledu řízení kvality a představit konkrétní metodiku, která umožňuje řízení kvality dat a informací napříč těmito zdroji. Hlavní součástí této metodiky je sada základních principů a činností, které je možné univerzálně aplikovat. Jedním z klíčových doporučení této metodiky je zaměření se na relativně malou sadu vlastností dat, kterou lze efektivně řídit. Součástí metodiky je rovněž model zralosti datového zdroje, který slouží pro zhodnocení míry rizika spojené s použitím konkrétního zdroje.

  5. Problematika zálohování a uchovávání dat v malých a středních podnicích

    OpenAIRE

    Hrach, Vlastimil

    2009-01-01

    Tato bakalářská práce upozorňuje na hojně opomíjenou důležitost firemních dat a jejich ochranu. Seznamuje s procesem zálohování jako základním prvkem bezpečnosti a efektivnosti informačního systému. Prezentuje výsledky mezinárodních studií na téma „Cena ztracených dat“, popisuje technologie diskových polí RAID, obecnou topologii LAN sítí a technologie DAS, NAS a SAN. Součástí práce jsou základní i pokročilé metody zálohování vhodné pro malé a střední podniky, v závislosti na jejich potřebě a ...

  6. Dolování dat

    OpenAIRE

    Stehno, David

    2013-01-01

    Cílem diplomové práce bylo nastudovat a popsat metodologii dolování dat CRISP-DM. Ze získané databáze byla prováděna predikce počtu hovorů na call centrum, přičemž bylo postupováno podle metodiky CRISP-DM. Ve fázi modelování byly použity 4 druhy modelů a to K-NN, neuronová síť, lineární regrese a model využívající metodu podpůrných vektorů. Pomocí různých druhů selekcí bylo zhodnoceno, které vstupní atributy mají důležitou roli pro výslednou predikci. Získané výsledky a poznatky mohou v budou...

  7. DAT positivity in blood donors: a perplexing scenario.

    Science.gov (United States)

    Bedi, Ravneet Kaur; Mittal, Kshitija; Sood, Tanvi; Kumar, Rakesh; Praveen, Ajay S

    2014-04-01

    A blood request was received for 70 year male patient suffering from Chronic Obstructive Pulmonary Disease with anemia. One unit was found incompatible in AHG phase. Patient's antibody screen, indirect antiglobulin test (IAT), direct antiglobulin test (DAT) and auto control was negative. DAT of donor unit was positive with anti IgG gel card and negative with C3d reagent along with positive auto control. Donor was 30 year male with no history of blood transfusion and medication and had no evidence of hemolysis. Donors with positive DAT should be deferred, notified and referred to physician but further studies are required. Copyright © 2014 Elsevier Ltd. All rights reserved.

  8. SGNucDat. Safeguards nuclear data for windows. Summary documentation

    International Nuclear Information System (INIS)

    Lemmel, H.D.; Schwerer, O.

    1996-01-01

    SGNucDat is a PC code displaying recommended values of nuclear data that are required for nuclear materials analyses by IAEA safeguards. Diskette and report available from the IAEA Nuclear Data Section, costfree upon request. (author)

  9. PCNuDAT a PC Nuclear Data program

    International Nuclear Information System (INIS)

    Kinsey, R.R.

    1998-01-01

    The PC program PCNuDat is described which displays nuclear radioactive decay data and thermal cross section data. It requires 45 Megabytes (reduced version of PCNuDat requires 3 Megabytes) of disc space and can be obtained through Internet FTP or WWW from U.S. Nuclear Data Center or Nuclear Data Section of the IAEA. It can be obtained also on CD-ROM upon request sent to Nuclear Data Section. (author)

  10. Genotype and ancestry modulate brain's DAT availability in healthy humans

    International Nuclear Information System (INIS)

    Shumay, E.; Chen, J.; Fowler, J.S.; Volkow, N.D.

    2011-01-01

    The dopamine transporter (DAT) is a principal regulator of dopaminergic neurotransmission and its gene (the SLC6A3) is a strong biological candidate gene for various behavioral- and neurological disorders. Intense investigation of the link between the SLC6A3 polymorphisms and behavioral phenotypes yielded inconsistent and even contradictory results. Reliance on objective brain phenotype measures, for example, those afforded by brain imaging, might critically improve detection of DAT genotype-phenotype association. Here, we tested the relationship between the DAT brain availability and the SLC6A3 genotypes using an aggregate sample of 95 healthy participants of several imaging studies. These studies employed positron emission tomography (PET) with [ 11 C] cocaine wherein the DAT availability was estimated as Bmax/Kd; while the genotype values were obtained on two repeat polymorphisms - 3-UTR- and intron 8- VNTRs. The main findings are the following: (1) both polymorphisms analyzed as single genetic markers and in combination (haplotype) modulate DAT density in midbrain; (2) ethnic background and age influence the strength of these associations; and (3) age-related changes in DAT availability differ in the 3-UTR and intron8 - genotype groups.

  11. Sturen op geluk: is dat mogelijk en wenselijk?

    NARCIS (Netherlands)

    R. Veenhoven (Ruut)

    2012-01-01

    textabstractHet idee dat de overheid zou moeten sturen op geluk is meer dan 200 jaar geleden al bepleit door Jeremy Bentham (1789). Volgens hem moeten wij streven naar groter geluk voor een groter aantal mensen, ook bij het maken van publieke keuzen. Dit heet in het filosofenjargon ‘politiek

  12. Inzicht in beslisgedrag maakt dat meer burgers meedoen

    NARCIS (Netherlands)

    Kerstholt, J.H.

    2014-01-01

    Participatiesamenleving Inzicht in beslisgedrag maakt dat meer burgers meedoen Waar was de bank van de dode buurvrouw? De sekte van de burgerkracht Al het werk is zingevend, ook het vrijwillige De ondernemende burger rukt op, schort het oordeel even op Blij met het luide debat over de

  13. Od naměřených dat k jejich matematickému popisu pomocí funkce - a zase zpátky

    Czech Academy of Sciences Publication Activity Database

    Segeth, Karel

    2015-01-01

    Roč. 60, č. 2 (2015), s. 133-147 ISSN 0032-2423 Institutional support: RVO:67985840 Keywords : measurement * interpolation * approximation Subject RIV: BA - General Mathematics http://hdl.handle.net/10338.dmlcz/144407

  14. [(123)I]FP-CIT ENC-DAT normal database

    DEFF Research Database (Denmark)

    Tossici-Bolt, Livia; Dickson, John C; Sera, Terez

    2017-01-01

    quantifications methods, BRASS and Southampton, and explores the performance of the striatal phantom calibration in their harmonisation. RESULTS: BRASS and Southampton databases comprising 123 ENC-DAT subjects, from gamma cameras with parallel collimators, were reconstructed using filtered back projection (FBP......) and iterative reconstruction OSEM without corrections (IRNC) and compared against the recommended OSEM with corrections for attenuation and scatter and septal penetration (ACSC), before and after applying phantom calibration. Differences between databases were quantified using the percentage difference......-camera variability (-0.2%, p = 0.44). CONCLUSIONS: The ENC-DAT reference values are significantly dependent on the reconstruction and quantification methods and phantom calibration, while reducing the major part of their differences, is unable to fully harmonize them. Clinical use of any normal database, therefore...

  15. [(123)I]FP-CIT ENC-DAT normal database

    DEFF Research Database (Denmark)

    Tossici-Bolt, Livia; Dickson, John C; Sera, Terez

    2017-01-01

    BACKGROUND: [(123)I]FP-CIT is a well-established radiotracer for the diagnosis of dopaminergic degenerative disorders. The European Normal Control Database of DaTSCAN (ENC-DAT) of healthy controls has provided age and gender-specific reference values for the [(123)I]FP-CIT specific binding ratio...... quantifications methods, BRASS and Southampton, and explores the performance of the striatal phantom calibration in their harmonisation. RESULTS: BRASS and Southampton databases comprising 123 ENC-DAT subjects, from gamma cameras with parallel collimators, were reconstructed using filtered back projection (FBP......) and iterative reconstruction OSEM without corrections (IRNC) and compared against the recommended OSEM with corrections for attenuation and scatter and septal penetration (ACSC), before and after applying phantom calibration. Differences between databases were quantified using the percentage difference...

  16. Nuclear data retrieval for PC applications, PCNuDat

    International Nuclear Information System (INIS)

    Kinsey, R.R.

    1996-01-01

    The PCNuDat program for IBM-PC compatibles is similar to the NuDat program available through the NNDC Online Nuclear Data Service. They provide a user with access to nuclear data in a convenient and menu driven system. This data is useful in both basic and applied research. The nuclear base used by NuDat is extracted from several data bases maintained at the National Nuclear Data Center (NNDC). The program is an extended DOS program which uses 32 bit addressing. It can run in a DOS window on all the current Windows operating systems. The program and its data base are currently available on both a CD-ROM or electronically over the Internet. Electronic access can be made through the NNDC's Web home page. The files may also be FTP'd from the public area under the [pc prog] directory on bnlnd2.dne.bnl.gov. The CD-ROM version also contains the Nuclear Science References (NSR) data base and its retrieval program, Papyrus NSR

  17. NuDat system for access to nuclear data

    International Nuclear Information System (INIS)

    Dunford, C.L.; Kinsey, R.R.

    1998-01-01

    The NuDat program provides a user with access to nuclear properties and to some nuclear reaction data. The program operates on DEC VMS operating systems and on PC's with Microsoft operating systems. The program has four user interfaces, all having the same content and functionality. These interfaces are Web, Video and Sequential for VMS. The PC interface is identical to the VMS Video interface. Forms are used to supply the type of data the user desires, the retrieval parameters, the output format, and the sort order of the data. The program and associated database is used in basic research, particularly for the systematic study of nuclear properties. It is also a useful tool for applied research to identify radiations from radionuclides contained in environmental samples, or from those produced by neutron or charged particle activation. The NuDat database is derived from several databases maintained by the National Nuclear Data Center. The databases are the Adopted Levels and Gammas data sets from ENSDF, the Nuclear Wallet Cards, Decay Radiations derived from ENSDF decay data sets processed by RADLIST, and Thermal Neutron Cross Sections

  18. Forma dat esse: a Christian ontology of human spirit

    Directory of Open Access Journals (Sweden)

    Joan Martínez Porcell

    2015-09-01

    Full Text Available Forma dat esse was initially high fertility existential anthropology. Christian philosophy inherited although explanations hylemorphic with explaining human nature knew register the being and doing of the person inside the ontology of created spirits. The presence of human corporeality was a spirit that existed in the boundary and the horizon of eternity. The plasticity of human tendencies was a sign of his intelligence and it should be defined by their spirituality. The word was being-communication and love was the most important act of his life fertility. No wonder that we offer existential self as memory itself and the presence of the soul from the patenting of his spiritual being.

  19. Dopamine transporter polymorphism modulates oculomotor function and DAT1 mRNA expression in schizophrenia.

    Science.gov (United States)

    Wonodi, Ikwunga; Hong, L Elliot; Stine, O Colin; Mitchell, Braxton D; Elliott, Amie; Roberts, Rosalinda C; Conley, Robert R; McMahon, Robert P; Thaker, Gunvant K

    2009-03-05

    Smooth pursuit eye movement (SPEM) deficit is an established schizophrenia endophenotype with a similar neurocognitive construct to working memory. Frontal eye field (FEF) neurons controlling SPEM maintain firing when visual sensory information is removed, and their firing rates directly correlate with SPEM velocity. We previously demonstrated a paradoxical association between a functional polymorphism of dopamine signaling (COMT gene) and SPEM. Recent evidence implicates the dopamine transporter gene (DAT1) in modulating cortical dopamine and associated neurocognitive functions. We hypothesized that DAT1 10/10 genotype, which reduces dopamine transporter expression and increases extracellular dopamine, would affect SPEM. We examined the effects of DAT1 genotype on: Clinical diagnosis in the study sample (n = 418; 190 with schizophrenia), SPEM measures in a subgroup with completed oculomotor measures (n = 200; 87 schizophrenia), and DAT1 gene expression in FEF tissue obtained from postmortem brain samples (n = 32; 16 schizophrenia). DAT1 genotype was not associated with schizophrenia. DAT1 10/10 genotype was associated with better SPEM in healthy controls, intermediate SPEM in unaffected first-degree relatives of schizophrenia subjects, and worse SPEM in schizophrenia subjects. In the gene expression study, DAT1 10/10 genotype was associated with significantly reduced DAT1 mRNA transcript in FEF tissue from healthy control donors (P < 0.05), but higher expression in schizophrenia donors. Findings suggest regulatory effects of another gene(s) or etiological factor in schizophrenia, which modulate DAT1 gene function. 2008 Wiley-Liss, Inc.

  20. A peptide disrupting the D2R-DAT interaction protects against dopamine neurotoxicity.

    Science.gov (United States)

    Su, Ping; Liu, Fang

    2017-09-01

    Dopamine reuptake from extracellular space to cytosol leads to accumulation of dopamine, which triggers neurotoxicity in dopaminergic neurons. Previous studies have shown that both dopamine D2 receptor (D2R) and dopamine transporter (DAT) are involved in dopamine neurotoxicity. However, blockade of either D2R or DAT causes side effects due to antagonism of other physiological functions of these two proteins. We previously found that DAT can form a protein complex with D2R and its cell surface expression is facilitated via D2R-DAT interaction, which regulates dopamine reuptake and intracellular dopamine levels. Here we found that an interfering peptide (DAT-S1) disrupting the D2R-DAT interaction protects neurons against dopamine neurotoxicity, and this effect is mediated by inhibiting DAT cell surface expression and inhibiting both caspase-3 and PARP-1 cleavage. This study demonstrates the role of the D2R-DAT complex in dopamine neurotoxicity and investigated the potential mechanisms, which might help better understand the mechanisms of dopamine neurotoxicity. The peptide may provide some insights to improve treatments for dopamine neurotoxicity and related diseases, such as Parkinson's disease, as well as methamphetamine- and 3,4-methsylenedioxy methamphetamine-induced neurotoxicity. Copyright © 2017. Published by Elsevier Inc.

  1. Carboxyhemoglobin levels as a predictor of risk for significant hyperbilirubinemia in African-American DAT(+) infants.

    Science.gov (United States)

    Schutzman, D L; Gatien, E; Ajayi, S; Wong, R J

    2016-05-01

    To compare the degree of hemolysis in a group of direct antiglobulin test (DAT) positive (pos) African-American (AA) infants as measured by carboxyhemoglobin corrected (COHbc) for carbon monoxide in ambient air to a similar group of DAT negative (neg) ABO incompatible infants and a group without blood group incompatibility. To determine if COHbc is a better predictor of significant hyperbilirubinemia than DAT status. A prospective study of 180 AA infants from the Well-Baby Nursery of an inner city community hospital, all of whose mothers were type O pos. Infants (60) were ABO incompatible DAT pos, 60 were ABO incompatible DAT neg and 60 were type O(+). Blood for COHbc was drawn at the time of the infants' initial bilirubin and the infants' precise percentile on the Bhutani nomogram was calculated. Mean COHbc of type O(+) infants was 0.76±0.21 and 0.78±0.24% for ABO incompatible DAT neg infants (P=0.63). Mean CoHbc for the ABO incompatible DAT pos infants was 1.03±0.41% (P0.90% (area under the curve(AUC) 0.8113). This was similar to the AUC of the receiver operating characteristic curve using any titer strength of DAT pos as a cutoff (0.7960). Although not greatly superior to the titer strength of DAT pos, COHbc is useful in determining if the etiology of severe hyperbilirubinemia is a hemolytic process.

  2. European multicentre database of healthy controls for [(123)I]FP-CIT SPECT (ENC-DAT)

    DEFF Research Database (Denmark)

    Varrone, Andrea; Dickson, John C; Tossici-Bolt, Livia

    2013-01-01

    of quantification is the availability of normative data, considering possible age and gender effects on DAT availability. The aim of the European Normal Control Database of DaTSCAN (ENC-DAT) study was to generate a large database of [(123)I]FP-CIT SPECT scans in healthy controls....

  3. Interaction of Dopamine Transporter (DAT1) Genotype and Maltreatment for ADHD: A Latent Class Analysis

    Science.gov (United States)

    Li, James J.; Lee, Steve S.

    2012-01-01

    Background: Although the association of the dopamine transporter (DAT1) gene and attention-deficit/hyperactivity disorder (ADHD) has been widely studied, far less is known about its potential interaction with environmental risk factors. Given that maltreatment is a replicated risk factor for ADHD, we explored the interaction between DAT1 and…

  4. Dat nooit meer’ – ‘Never Again’

    Directory of Open Access Journals (Sweden)

    James Kennedy

    2013-06-01

    Full Text Available In October of 2011 the Dutch historian and journalist Chris van der Heijden defended his dissertation Dat nooit meer – ‘Never Again’ which came out at the same time in a trade edition. In his 900-page magnum opus, supervised by the historians Hans Blom and Ido de Haan, Van der Heijden attempted to reconstruct ‘the aftermath of the Second World War in the Netherlands’. To do this, he offered a ‘thick description’ of incidents, affairs, public events and contemporary historiography, which togetherconstructed the culture and politics of memory about that war. Van der Heijden’s work immediately generated controversy in the Netherlands. Various historians at the public defence of the dissertation expressedfundamental criticisms of the book, a trend also evident in the media and in several reviews. The disapproval addressed the author’s method, use of sources and interpretative framework (or lack thereof, often in strong terms. Van der Heijden started a web-based blog to answer his critics and a heated debate continued for some time.

  5. DAT by perceived MC interaction on human prefrontal activity and connectivity during emotion processing.

    Science.gov (United States)

    Taurisano, Paolo; Blasi, Giuseppe; Romano, Raffaella; Sambataro, Fabio; Fazio, Leonardo; Gelao, Barbara; Ursini, Gianluca; Lo Bianco, Luciana; Di Giorgio, Annabella; Ferrante, Francesca; Papazacharias, Apostolos; Porcelli, Annamaria; Sinibaldi, Lorenzo; Popolizio, Teresa; Bertolino, Alessandro

    2013-12-01

    Maternal care (MC) and dopamine modulate brain activity during emotion processing in inferior frontal gyrus (IFG), striatum and amygdala. Reuptake of dopamine from the synapse is performed by the dopamine transporter (DAT), whose abundance is predicted by variation in its gene (DAT 3'VNTR; 10 > 9-repeat alleles). Here, we investigated the interaction between perceived MC and DAT 3'VNTR genotype on brain activity during processing of aversive facial emotional stimuli. Sixty-one healthy subjects were genotyped for DAT 3'VNTR and categorized in low and high MC individuals. They underwent functional magnetic resonance imaging while performing a task requiring gender discrimination of facial stimuli with angry, fearful or neutral expressions. An interaction between facial expression, DAT genotype and MC was found in left IFG, such that low MC and homozygosity for the 10-repeat allele are associated with greater activity during processing of fearful faces. This greater activity was also inversely correlated with a measure of emotion control as scored with the Big Five Questionnaire. Moreover, MC and DAT genotype described a double dissociation on functional connectivity between IFG and amygdala. These findings suggest that perceived early parental bonding may interact with DAT 3'VNTR genotype in modulating brain activity during emotionally relevant inputs.

  6. NuDat 2.0: Nuclear Structure and Decay Data on the Internet

    International Nuclear Information System (INIS)

    Sonzogni, A.A.

    2005-01-01

    NuDat 2.0 is a software product developed by the National Nuclear Data Center. It provides an interface between web users and several NNDC nuclear structure and decay databases. NuDat 2.0 can be used to search for ground and excited states level properties, gamma-ray information, and decay radiation information. In addition to the search capabilities, an interactive chart of nuclei is displayed. Different examples highlighting NuDat 2 search capabilities and display options are presented

  7. Visceral leishmaniasis in Bangladesh: the value of DAT as a diagnostic tool.

    Science.gov (United States)

    el-Masum, M A; Evans, D A; Minter, D M; el Harith, A

    1995-01-01

    The direct agglutination test (DAT) was performed on 480 serum samples from suspected cases of visceral leishmaniasis (VL) in different parts of Bangladesh. Significant titres (> or = 1:3200) were found in 257 sera (53.5%). All patients with positive bone-marrow aspirates also had significant DAT titres. The male:female seroprevalence ratio was 2:1 and the age-group 0-20 years was the most affected. The DAT proved a simple, economical and reliable diagnostic test for VL.

  8. A survey on draught animal technology (DAT) in EN-Nhoud area, North Kordofan State, Sudan.

    Science.gov (United States)

    Makki, Elsamawal Khalil; Musa, Ezdehar Omer Mohammed

    2011-06-01

    Draught animal technology (DAT) can potentially play a central role in agriculture transformation for traditional farmers. This study surveyed the state of DAT in En-Nhoud area, North Kordofan State, Sudan in an attempt to have a clear view of the changes brought about by introducing the technology. The study followed the cross-sectional survey design. Farmers were selected from ten clusters (villages) and data were collected using questionnaires and face to face interviews with farmers in addition to group discussions with them and the different actors in the field. The results showed that farmers appreciate the role played by DAT, but they highlighted the need for further capacity building and technical backup. Harnessing issues are not well understood and applied by the farmers. The different actors involved in DAT in the area lack networking and coordination, and this reflected on the many problems and constraints faced by the farmers.

  9. Genotype and ancestry modulate brain's DAT availability in healthy humans

    Energy Technology Data Exchange (ETDEWEB)

    Shumay, E.; Shumay, E.; Chen, J.; Fowler, J.S.; Volkow, N.D.

    2011-08-01

    The dopamine transporter (DAT) is a principal regulator of dopaminergic neurotransmission and its gene (the SLC6A3) is a strong biological candidate gene for various behavioral- and neurological disorders. Intense investigation of the link between the SLC6A3 polymorphisms and behavioral phenotypes yielded inconsistent and even contradictory results. Reliance on objective brain phenotype measures, for example, those afforded by brain imaging, might critically improve detection of DAT genotype-phenotype association. Here, we tested the relationship between the DAT brain availability and the SLC6A3 genotypes using an aggregate sample of 95 healthy participants of several imaging studies. These studies employed positron emission tomography (PET) with [{sup 11}C] cocaine wherein the DAT availability was estimated as Bmax/Kd; while the genotype values were obtained on two repeat polymorphisms - 3-UTR- and intron 8- VNTRs. The main findings are the following: (1) both polymorphisms analyzed as single genetic markers and in combination (haplotype) modulate DAT density in midbrain; (2) ethnic background and age influence the strength of these associations; and (3) age-related changes in DAT availability differ in the 3-UTR and intron8 - genotype groups.

  10. The effects of DAT1 genotype on fMRI activation in an emotional go/no-go task.

    Science.gov (United States)

    Brown, Brenna K; Murrell, Jill; Karne, Harish; Anand, Amit

    2017-02-01

    Dopaminergic brain circuits participate in emotional processing and impulsivity. The dopamine transporter (DAT) modulates dopamine reuptake. A variable number tandem repeat (VNTR) in the dopamine transporter gene (DAT1) affects DAT expression. The influence of DAT1 genotype on neural activation during emotional processing and impulse inhibition has not been examined. Forty-two healthy subjects were classified as 9DAT (n = 17) or 10DAT (n = 25) based on DAT1 genotype (9DAT = 9R/9R and 9R/10R; 10DAT = 10R/10R). Subjects underwent fMRI during non-emotional and emotional go/no-go tasks. Subjects were instructed to inhibit responses to letters, happy faces, or sad faces in separate blocks. Accuracy and reaction time did not differ between groups. Within group results showed activation in regions previously implicated in emotional processing and response inhibition. Between groups results showed increased activation in 9DAT individuals during inhibition. During letter inhibition, 9DAT individuals exhibited greater activation in right inferior parietal regions. During sad inhibition, 9DAT Individuals exhibited greater activation in frontal, posterior cingulate, precuneus, right cerebellar, left paracentral, and right occipital brain regions. The interaction between DAT genotype and response type in sad versus letter stimuli showed increased activation in 9DAT individuals during sad no-go responses in the anterior cingulate cortex, extending into frontal-orbital regions. 9DAT individuals have greater activation than 10DAT individuals during neutral and sad inhibition, showing that genotypic variation influencing basal dopamine levels can alter the neural basis of emotional processing and response inhibition. This may indicate that 9R carriers exert more effort to overcome increased basal dopamine activation when inhibiting responses in emotional contexts.

  11. Zdaňování nemovitostí a jejich převodů

    OpenAIRE

    Slezáková, Alžběta

    2009-01-01

    Alžběta Slezáková Zdaňování nemovitostí a jejich převodů 70 ABSTRACT "Taxation of real property and their transfers" The topic of the submitted thesis is a survey of historical and mainly current situation of legal regulation of property taxes in the Czech Republic, except the vehicle excise duty. Ownership, usage and transfers of real property are affected not only by real estate tax, gift tax, succession duty, real estate-transfer tax, but also by income taxes and VAT. Considering the exten...

  12. Promoter Methylation and BDNF and DAT1 Gene Expression Profiles in Patients with Drug Addiction.

    Science.gov (United States)

    Kordi-Tamandani, Dor Mohammad; Tajoddini, Shahrad; Salimi, Farzaneh

    2015-01-01

    Drug addiction is a brain disorder that has negative consequences for individuals and society. Addictions are chronic relapsing diseases of the brain that are caused by direct drug-induced effects and persevering neuroadaptations at the epigenetic, neuropeptide and neurotransmitter levels. Because the dopaminergic system has a significant role in drug abuse, the purpose of this study was to analyze the methylation and expression profile of brain-derived neurotrophic factor (BDNF) and dopamine transporter (DAT1) genes in individuals with drug addiction. BDNF and DAT1 promoter methylation were investigated with a methylation-specific polymerase chain reaction (PCR) technique in blood samples from 75 individuals with drug addiction and 65 healthy controls. The expression levels of BDNF and DAT1 were assessed in 12 mRNA samples from the blood of patients and compared to the samples of healthy controls (n = 12) with real-time quantitative reverse transcription PCR. No significant differences were found in the methylation of BDNF and DAT1 between patients and controls, but the relative levels of expression of BDNF and DAT1 mRNA differed significantly in the patients compared to controls (p drug addiction.

  13. Transformation of model data to information - experiences with coastDat

    Science.gov (United States)

    Meyer, E.; Weisse, R.

    2016-02-01

    The idea of coastDat is to improve the data base in sparse observational marine regions and to increase data homogeneity and consistency. In doing so long-term historical model data of e.g. wind (e.g. storms), wind wave and tide surge hindcasts are developed and proofed for regions like North Sea and Baltic Sea. These data-sets are available in hourly resolution and highly spatial resolution to simulate the marine environment from 1948/1958 up to now. Scenarios of potential future developments in a changing climate are also available. The coastDat data sets are used for applications e.g. offshore wind industry (design & logistics), risk analysis and analysis of pathways of energy transition. More than 80 stakeholders have used coastDat data sets. They are composed of science networks (31%), economic actors (45 %) and administrating policy actors (14%). The idea of coastDat is compatible in other coastal regions. Also coastDat is suitable as an information base in order to develop possible future adaptation measures. Here the data set and the history are briefly described, validation is reviewed, and an overview about recent uses of the data is provided.

  14. Ekonomické systémy MMORPG, jejich výhody a nevýhody

    OpenAIRE

    Havel, Vojtěch

    2008-01-01

    Cílem mé práce je popsat vnitřní ekonomiky MMORPG a diskutovat jejich potenciál jakožto vhodných virtuálních simulací reálného světa pro potřeby výzkumu ekonomických teorií a vztahů. První kapitola je zaměřena na postupný historický vznik žánru RPG a MMORPG a jejich základní pravidla. Druhá se zabývá metodami a postupy ekonomického výzkumu v dnešní době. Třetí navrhuje, proč by použití MMORPG bylo v tomto kontextu výhodné. Ve čtvrté se zabývám nedostatky, neduhy a limity těchto virtuálních sv...

  15. Interaction between striatal volume and DAT1 polymorphism predicts working memory development during adolescence

    Directory of Open Access Journals (Sweden)

    F. Nemmi

    2018-04-01

    Full Text Available There is considerable inter-individual variability in the rate at which working memory (WM develops during childhood and adolescence, but the neural and genetic basis for these differences are poorly understood. Dopamine-related genes, striatal activation and morphology have been associated with increased WM capacity after training. Here we tested the hypothesis that these factors would also explain some of the inter-individual differences in the rate of WM development.We measured WM performance in 487 healthy subjects twice: at age 14 and 19. At age 14 subjects underwent a structural MRI scan, and genotyping of five single nucleotide polymorphisms (SNPs in or close to the dopamine genes DRD2, DAT-1 and COMT, which have previously been associated with gains in WM after WM training. We then analyzed which biological factors predicted the rate of increase in WM between ages 14 and 19.We found a significant interaction between putamen size and DAT1/SLC6A3 rs40184 polymorphism, such that TC heterozygotes with a larger putamen at age 14 showed greater WM improvement at age 19.The effect of the DAT1 polymorphism on WM development was exerted in interaction with striatal morphology. These results suggest that development of WM partially share neuro-physiological mechanism with training-induced plasticity. Keywords: Working memory, Development, Dopamine, Striatum, DAT-1, rs40184

  16. ADHD and DAT1: Further evidence of paternal over-transmission of risk alleles and haplotype

    NARCIS (Netherlands)

    Hawi, Z.; Kent, L.; Hill, M.; Anney, R.J.; Brookes, K. J.; Barry, E.; Franke, B.; Banaschewski, T.; Buitelaar, J.; Ebstein, R.; Miranda, A.; Oades, R.D.; Roeyers, H.; Rothenberger, A.; Sergeant, J.A.; Sonuga-Barke, E.; Steinhausen, H.C.; Faraone, S.V.; Asherson, P.; Gill, M.

    2009-01-01

    We [Hawi et al. (2005); Am J Hum Genet 77:958-965] reported paternal over-transmission of risk alleles in some ADHD-associated genes. This was particularly clear in the case of the DAT1 30-UTR VNTR. In the current investigation, we analyzed three new sample comprising of 1,248 ADHD nuclear families

  17. ADHD and DAT1: further evidence of paternal over-transmission of risk alleles and haplotype.

    NARCIS (Netherlands)

    Hawi, Z.; Kent, L.; Hill, M.; Anney, R.J.; Brookes, K.J.; Barry, E.; Franke, B.; Banaschewski, T.; Buitelaar, J.K.; Ebstein, R.; Miranda, A.; Oades, R.D.; Roeyers, H.; Rothenberger, A.; Sergeant, J.A.; Sonuga-Barke, E.J.S.; Steinhausen, H.C.; Faraone, S.V.; Asherson, P.; Gill, M.

    2010-01-01

    We [Hawi et al. (2005); Am J Hum Genet 77:958-965] reported paternal over-transmission of risk alleles in some ADHD-associated genes. This was particularly clear in the case of the DAT1 3'-UTR VNTR. In the current investigation, we analyzed three new sample comprising of 1,248 ADHD nuclear families

  18. Geochemical characterization of mid-distal Nisyros tephra on Datça peninsula (southwestern Anatolia)

    Science.gov (United States)

    Gençalioğlu-Kuşcu, Gonca; Uslular, Göksu

    2018-04-01

    We present new distal records of tephra deposits that overly the Kos ignimbrite in seven locations of Datça peninsula. Tephra in one of these locations were previously associated with Nisyros Kyra sub-unit based only on the field characteristics. We use different proxies such as field observations, petrography, mineral, glass, and whole-rock chemistry in order to characterize and correlate the previously and recently identified pumice fall deposits on Datça. The total thickness of the fall deposit reaches to 3.5 m. The size of the pumice clasts is generally within the range of lapilli, and they have vitrophyric texture consisting mainly of plagioclase (andesine to labradorite) with scarce clinopyroxene (diopside to augite), olivine (Fo48-50), amphibole (magnesio-hastingsite), and biotite crystals. Amphibole is a ubiquitous phenocryst in all Datça tephra units and used as a criterion for the correlation. Glass major element analyses by EMPA reveal two different groups with andesitic and dacitic compositions. Difference in silica content (up to ca. 4 wt%) detected in the same specimen also designates the heterogeneity in pumice glass. This heterogeneity in glass composition is also supported by the frequent occurrence of banded pumice clasts in Datça tephra. Whole-rock composition of the pumice is mainly andesitic with calc-alkaline affinity. Multi-element patterns on primitive-mantle normalized diagram display typical arc-magmatism signature (i.e. depletion in Nb, Ta, Ti, and P). In order to check and eliminate the potential alternatives, we compared the distal deposits on Datça not only with Kyra, but also with other Nisyros tephra units. Yet, Kyra is the only unit that has comparable depositional characteristics, calcic amphibole crystals, andesitic-dacitic glass and whole-rock chemistry, and distal tephra deposits on neighboring islands (Tilos and Chalki). Therefore, we associate Datça tephra deposits with some proximal Kyra subunits of intermediate

  19. Rizika prognózy tržeb na základě historických dat a jejich důsledky pro vypočtenou hodnotu podniku

    Directory of Open Access Journals (Sweden)

    Michal Karas

    2013-11-01

    Full Text Available Purpose of the article: This paper deals with statistical methods of sales forecasting and their impact on calculated business value using the income capitalization approach. Our aim was to present several statistical methods used in practice for sales forecasting and demonstrate the limitation of their use. Scientific aim: The main scientific aim of this paper is to answer following questions: Will the use of error function, presented in literature, lead to choosing the most accurate method for sales forecasting? Even under the situation of unstable development of the company’s environment. How accurate is possible to calculate the business value? Methodology/methods: For creating a sale prognosis we used basic statistical methods e.g. time series and regression analysis using one dimensional model. For forecast error evaluation we used following error function: mean error, mean square error, Spearman’s coefficient, index of determination, Thiel’s index and so on. For calculating business value we used the DCF entity and EVA/MVA entity model. Findings: The method selected on the basis of error functions, presented in literature, lead to largest forecast error among presented methods. Under the situation of sustainable development of environment, this error function has a limited used. Conclusions: We agree with Little, Damodaran, Makridakis, Taleb ho claim that the forecast of sales based on historical data could not lead to most accurate results. We suggest to combine statistical methods with judgmental forecasts as it is presented in work of O’Connor, Remus and Griggs.

  20. Kombinatorika temporálních konektorů: jejich sémanticko-pragmatická a stylistická profilace (získaná interpretací korpusových dat)

    Czech Academy of Sciences Publication Activity Database

    Hoffmannová, Jana; Kolářová, I.

    2007-01-01

    Roč. 16, - (2007), s. 81-93 ISSN 1230-2287 R&D Projects: GA ČR GA405/06/1057 Institutional research plan: CEZ:AV0Z90610518 Keywords : stylistics * pragmatics * semantics * corpus linguistics Subject RIV: AI - Linguistics

  1. The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants.

    Science.gov (United States)

    Mergy, Marc A; Gowrishankar, Raajaram; Gresch, Paul J; Gantz, Stephanie C; Williams, John; Davis, Gwynne L; Wheeler, C Austin; Stanwood, Gregg D; Hahn, Maureen K; Blakely, Randy D

    2014-11-04

    Despite the critical role of the presynaptic dopamine (DA) transporter (DAT, SLC6A3) in DA clearance and psychostimulant responses, evidence that DAT dysfunction supports risk for mental illness is indirect. Recently, we identified a rare, nonsynonymous Slc6a3 variant that produces the DAT substitution Ala559Val in two male siblings who share a diagnosis of attention-deficit hyperactivity disorder (ADHD), with other studies identifying the variant in subjects with bipolar disorder (BPD) and autism spectrum disorder (ASD). Previously, using transfected cell studies, we observed that although DAT Val559 displays normal total and surface DAT protein levels, and normal DA recognition and uptake, the variant transporter exhibits anomalous DA efflux (ADE) and lacks capacity for amphetamine (AMPH)-stimulated DA release. To pursue the significance of these findings in vivo, we engineered DAT Val559 knock-in mice, and here we demonstrate in this model the presence of elevated extracellular DA levels, altered somatodendritic and presynaptic D2 DA receptor (D2R) function, a blunted ability of DA terminals to support depolarization and AMPH-evoked DA release, and disruptions in basal and psychostimulant-evoked locomotor behavior. Together, our studies demonstrate an in vivo functional impact of the DAT Val559 variant, providing support for the ability of DAT dysfunction to impact risk for mental illness.

  2. Carbon-11-labelling of a novel, trishomocubane-derived, high affinity and selectivity DAT ligand

    International Nuclear Information System (INIS)

    Dolle, F.; Le Helleix, St.; Peyronneau, M.A.; Saba, W.; Tournier, N.; Valette, H.; Banister, S.; Kassiou, M.

    2011-01-01

    Complete text of publication follows: Objectives: Parkinson's disease, schizophrenia, attention deficit disorder and drug abuse are related to abnormalities within the brain's dopaminergic system. The neuronal dopamine transporter (DAT) plays a key role in regulating the synaptic concentration of dopamine and thus dopamine neurotransmission in the brain. Since the DAT can be considered as a marker of the integrity and number of the presynaptic striatal dopamine-producing neurons, considerable efforts have been spent in recent years on the design and development of DAT-selective radioligands for use in Positron Emission Tomography (PET) studies. Notably, the tropane PE2I and its fluorinated analogue LBT-999 were identified as having high affinity and selectivity for the DAT over the norepinephrine transporter (NET) and the serotonin transporter (SERT). Besides tropanes, only a few bicyclic frameworks, e.g. bicyclo[2.2.2]octanes, have delivered compounds with high affinity for the DAT. Recently, novel poly-carbocyclic DAT ligands with selectivity over the NET and the SERT were reported. The lead compound of this series (1, N-methyl-N-(3-fluoro) benzyl-pentacyclo[5.4.0.0 2, 6 .0 3, 10 .0 5, 9 ] undec-8-ylamine, Ki = 1.2 nM, ≥ 8300-fold selectivity over NET and SERT) was selected as a potential candidate for imaging the DAT with PET and isotopically labelled with carbon-11 using [ 11 C]methyl triflate. Methods: The trishomocubane derivatives 1 (reference) and 2 (precursor for labelling with carbon-11) were prepared from commercially available Cookson's diketone in 6 and 7 steps, respectively. Carbon-11 labelling of 1 was performed using a TRACERLab FX-C Pro synthesizer (GEMS) and comprises (1) trapping at -10 C of [ 11 C]MeOTf in acetone (0.4 mL) containing the nor-derivative 2 (0.6-0.9 mg, free base) and aq. 3N NaOH (8 μL); (2) heating at 110 C for 2 min; (3) concentration to dryness and taking up the residue in 1.0 mL of the HPLC mobile phase; (4) purification

  3. Analýza nestrukturovaných dat z bankovních stránek na sociální síti Facebook

    Directory of Open Access Journals (Sweden)

    Lucie Šperková

    2014-12-01

    Full Text Available Sociální sítě jako novodobý kanál pro sdílení online Word of Mouth představuje pro bankovní společnosti příležitost, jak analyzovat komunikaci a názory svých zákazníků, které zde veřejně sdílejí. Článek ukazuje proces a výsledky pokročilé kontextové analýzy těchto nestrukturovaných dat vybraných veřejných bankovních stránek na sociální síti Facebook. Analýza zákaznických názorů, problémů a přání může hrát významnou roli pro pozici těchto společností na trhu a jejich orientaci na zákazníky. Využity byly metody shlukování a sentiment analýz, výsledky odrážejí stav chování zákazníků a bank na této síti. Článek zdůrazňuje důležitost problematiky Word of Mouth a jeho analýz informačními technologiemi. Zároveň diskutuje, jak analýza kontextu může přenést marketing na další úroveň identifikace zákazníkova chování a jeho vztahu ke společnosti.

  4. WebDat: bridging the gap between unstructured and structured data

    International Nuclear Information System (INIS)

    Nogiec, Jerzy M.; Trombly-Freytag, Kelley; Carcagno, Ruben

    2008-01-01

    Accelerator R and D environments produce data characterized by different levels of organization. Whereas some systems produce repetitively predictable and standardized structured data, others may produce data of unknown or changing structure. In addition, structured data, typically sets of numeric values, are frequently logically connected with unstructured content (e.g., images, graphs, comments). Despite these different characteristics, a coherent, organized and integrated view of all information is sought out. WebDat is a system conceived as a result of efforts in this direction. It provides a uniform and searchable view of structured and unstructured data via common metadata, regardless of the repository used (DBMS or file system). It also allows for processing data and creating interactive reports. WebDat supports metadata management, administration, data and content access, application integration via Web services, and Web-based collaborative analysis

  5. WebDat: bridging the gap between unstructured and structured data

    Energy Technology Data Exchange (ETDEWEB)

    Nogiec, Jerzy M.; Trombly-Freytag, Kelley; Carcagno, Ruben; /Fermilab

    2008-11-01

    Accelerator R&D environments produce data characterized by different levels of organization. Whereas some systems produce repetitively predictable and standardized structured data, others may produce data of unknown or changing structure. In addition, structured data, typically sets of numeric values, are frequently logically connected with unstructured content (e.g., images, graphs, comments). Despite these different characteristics, a coherent, organized and integrated view of all information is sought out. WebDat is a system conceived as a result of efforts in this direction. It provides a uniform and searchable view of structured and unstructured data via common metadata, regardless of the repository used (DBMS or file system). It also allows for processing data and creating interactive reports. WebDat supports metadata management, administration, data and content access, application integration via Web services, and Web-based collaborative analysis.

  6. The Role of the Dopamine Transporter (DAT) in the Development of PTSD in Preschool Children

    Science.gov (United States)

    Drury, Stacy S.; Theall, Katherine P.; Keats, Bronya J.B.; Scheeringa, Michael

    2015-01-01

    Population-based association studies have supported the heritability of posttraumatic stress disorder (PTSD). This study explored the influence of genetic variation in the dopamine transporter (DAT) 3′ untranslated region variable number tandem repeat on the development of PTSD in preschool children exposed to Hurricane Katrina, diagnosed using a developmentally appropriate semistructured interview. A diagnosis according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV; American Psychiatric Association, 1994), total symptoms, and specifically Criterion D symptoms were significantly more likely to be found in children with the 9 allele. This study replicates a previous finding in adults with PTSD. The specificity of this finding to the increased arousal symptoms of Criterion D suggests that dopamine and the DAT allele may contribute to one heritable path in a multifinality model of the development of PTSD. PMID:19960520

  7. DAT/SERT Selectivity of Flexible GBR 12909 Analogs Modeled Using 3D-QSAR Methods

    Science.gov (United States)

    Gilbert, Kathleen M.; Boos, Terrence L.; Dersch, Christina M.; Greiner, Elisabeth; Jacobson, Arthur E.; Lewis, David; Matecka, Dorota; Prisinzano, Thomas E.; Zhang, Ying; Rothman, Richard B.; Rice, Kenner C.; Venanzi, Carol A.

    2007-01-01

    The dopamine reuptake inhibitor GBR 12909 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine, 1) and its analogs have been developed as tools to test the hypothesis that selective dopamine transporter (DAT) inhibitors will be useful therapeutics for cocaine addiction. This 3D-QSAR study focuses on the effect of substitutions in the phenylpropyl region of 1. CoMFA and CoMSIA techniques were used to determine a predictive and stable model for the DAT/serotonin transporter (SERT) selectivity (represented by pKi (DAT/SERT)) of a set of flexible analogs of 1, most of which have eight rotatable bonds. In the absence of a rigid analog to use as a 3D-QSAR template, six conformational families of analogs were constructed from six pairs of piperazine and piperidine template conformers identified by hierarchical clustering as representative molecular conformations. Three models stable to y-value scrambling were identified after a comprehensive CoMFA and CoMSIA survey with Region Focusing. Test set correlation validation led to an acceptable model, with q2 = 0.508, standard error of prediction = 0.601, two components, r2 = 0.685, standard error of estimate = 0.481, F value = 39, percent steric contribution = 65, and percent electrostatic contribution = 35. A CoMFA contour map identified areas of the molecule that affect pKi (DAT/SERT). This work outlines a protocol for deriving a stable and predictive model of the biological activity of a set of very flexible molecules. PMID:17127069

  8. Treatment and remediation of a wastewater lagoon using microelectrolysis and modified DAT/IAT methods.

    Science.gov (United States)

    Wu, Qiong; Hua, Tao; Zhou, Qixing

    2011-01-01

    To examine treatment and remediation of a wastewater lagoon with poor biodegradability, a typical wastewater lagoon in Tianjin, China, was treated and remedied using microelectrolysis and modified demand aeration tank (DAT)/intermittent aeration tank (IAT) methods. After pretreatment by microelectrolysis, the removal efficiency of chemical oxygen demand (COD) was up to 64.6% and the ratio of BOC/COD in the effluent increased from 0.013 to 0.609. The removal rates of COD(Cr) and NH4(+)-N were affected by sludge backflow rate, mixed liquor suspended solids (MLSS), and hydraulic retention time (HRT) in the modified DAT/IAT reactor. The highest removal rates of COD(Cr) and NH4(+)-N were up to 78.9% and 62.6%, respectively, when the sludge backflow rate was 38.0 mL/min, the total HRT was 8.0 hr and MLSS was 4088.0 mg/L. In this case, some protozoa and metazoa were observed in activated sludge and biofilm carriers. Most of chrominance was removed by microelectrolysis treatment, while the modified DAT/IAT methods were more effective for COD(Cr) and NH4(+)-N removal.

  9. Association of ADHD, tics, and anxiety with dopamine transporter (DAT1) genotype in autism spectrum disorder.

    Science.gov (United States)

    Gadow, Kenneth D; Roohi, Jasmin; DeVincent, Carla J; Hatchwell, Eli

    2008-12-01

    Autism spectrum disorder (ASD) is associated with high rates of psychiatric disturbance to include attention-deficit/hyperactivity disorder (ADHD), tic disorder, and anxiety disorders. The aim of the present study was to examine the association between a variable number tandem repeat (VNTR) functional polymorphism located in the 3'-untranslated region of the dopamine transporter gene (DAT1) and the severity of these symptoms as well as the association between the DAT1 DdeI polymorphism and severity of tics. Parents (n = 62) and teachers (n = 57) completed a DSM-IV-referenced rating scale for 67 children with ASD. According to parent ratings, children with the 10-10 repeat allele (versus a combined group of all other genotypes) exhibited less severe symptoms of hyperactivity and impulsivity as well as less severe language deficits. Teacher ratings indicated that social anxiety and tic symptoms were more severe for children with the 10-10 genotype versus all others. Exploratory analyses provided preliminary support for the notion that heterozygosity (9-10 repeat genotype) may be a risk/protective factor. There were no associations of tic severity with the DAT1 DdeI polymorphism. Collectively, these results suggest that the extraordinary variability in ASD clinical phenotypes may be explained in part by the same genes that are implicated in a host of other psychiatric disorders in non-ASD populations. Nevertheless, replication with independent samples is necessary to confirm this preliminary finding.

  10. Sequence analysis of Drd2, Drd4, and Dat1 in SHR and WKY rat strains

    Directory of Open Access Journals (Sweden)

    Mill Jonathan

    2005-12-01

    Full Text Available Abstract Background The Spontaneously Hypertensive Rat (SHR shows a number of behaviours that closely parallel those seen in children with attention-deficit hyperactivity disorder. These include motor hyperactivity, excessive responses under a fixed-interval/extinction schedule, difficulty in acquiring operant tasks and increased sensitivity to immediate behavioural reinforcement. As in children with ADHD, the behavioural and cognitive deficits in the SHR are responsive to stimulants, including d-amphetamine and d,l-methylphenidate. The non-hyperactive Wistar Kyoto (WKY rat strain is often used as a control in behavioural studies of the SHR, and WKY itself has been suggested to be a useful animal model of depression. Numerous studies have shown that dopaminergic neurotransmission is altered between the two strains. Human genetic studies have found associations between several dopaminergic genes and both ADHD and depression. Methods We sequenced three candidate dopaminergic genes (Drd2, Drd4, and Dat1 in the SHR and WKY to identify between-strain sequence differences. Results No between-strain sequence differences were found in either Drd2 or Drd4, but several variations were found in the Dat1 gene that encodes the dopamine transporter. Conclusion It is plausible that DNA sequence changes in the Dat1 gene account for some of the behavioural differences observed between the SHR and WKY strains. Future work will focus on elucidating the functional effects of the observed polymorphisms.

  11. An Introduction to the DA-T Gibbs Sampler for the Two-Parameter Logistic (2PL Model and Beyond

    Directory of Open Access Journals (Sweden)

    Gunter Maris

    2005-01-01

    Full Text Available The DA-T Gibbs sampler is proposed by Maris and Maris (2002 as a Bayesian estimation method for a wide variety of Item Response Theory (IRT models. The present paper provides an expository account of the DAT Gibbs sampler for the 2PL model. However, the scope is not limited to the 2PL model. It is demonstrated how the DA-T Gibbs sampler for the 2PL may be used to build, quite easily, Gibbs samplers for other IRT models. Furthermore, the paper contains a novel, intuitive derivation of the Gibbs sampler and could be read for a graduate course on sampling.

  12. Immunization with DAT fragments is associated with long-term striatal impairment, hyperactivity and reduced cognitive flexibility in mice

    Directory of Open Access Journals (Sweden)

    Adriani Walter

    2012-11-01

    Full Text Available Abstract Background Possible interactions between nervous and immune systems in neuro-psychiatric disorders remain elusive. Levels of brain dopamine transporter (DAT have been implicated in several impulse-control disorders, like attention deficit / hyperactivity disorder (ADHD and obsessive-compulsive disorder (OCD. Here, we assessed the interplay between DAT auto-immunity and behavioural / neurochemical phenotype. Methods Male CD-1 mice were immunized with DAT peptide fragments (DAT-i, or vehicle alone (VEH, to generate elevated circulating levels of DAT auto-antibodies (aAbs. Using an operant delay-of-reward task (20 min daily sessions; timeout 25 sec, mice had a choice between either an immediate small amount of food (SS, or a larger amount of food after a delay (LL, which increased progressively across sessions (from 0 to 150 sec. Results DAT-i mice exhibited spontaneous hyperactivity (2 h-longer wake-up peak; a wake-up attempt during rest. Two sub-populations differing in behavioural flexibility were identified in the VEH control group: they showed either a clear-cut decision to select LL or clear-cut shifting towards SS, as expected. Compared to VEH controls, choice-behaviour profile of DAT-i mice was markedly disturbed, together with long-lasting alterations of the striatal monoamines. Enhanced levels of DA metabolite HVA in DAT-i mice came along with slower acquisition of basal preferences and with impaired shifting; elevation also in DOPAC levels was associated with incapacity to change a rigid selection strategy. This scarce flexibility of performance is indicative of a poor adaptation to task contingencies. Conclusions Hyperactivity and reduced cognitive flexibility are patterns of behaviour consistent with enduring functional impairment of striatal regions. It is yet unclear how anti-DAT antibodies could enter or otherwise affect these brain areas, and which alterations in DAT activity exactly occurred after immunization

  13. Combined DaT imaging and olfactory testing for differentiating parkinsonian disorders

    DEFF Research Database (Denmark)

    Borghammer, Per; Knudsen, K; Østergaard, K

    2014-01-01

    ObjectiveDopamine transporter (DaT) imaging with single photon emission computed tomography (SPECT) detects loss of striatal dopaminergic innervation with very high sensitivity. It cannot readily distinguish idiopathic Parkinson's disease (iPD) and dementia with Lewy bodies (DLB) from atypical...... predicted a dopamine-deficient diagnosis with 98% sensitivity and 98% specificity. The combined DaT/olfactory testing correctly classified 91% of patients as iPD/DLB (PPV 91%). The PPV rose to 97% or greater in anosmic patients. In contrast, only 45% of aPD patients were categorised correctly by combined Da...

  14. Evaluation of the possibility of estimating therapeutic response to Donepezil in patients with dat using ezis

    International Nuclear Information System (INIS)

    Joji Kawabe; Shigeaki Higashiyama; Terue Okamura; Hiroshi Hashimoto; Hisanori Akiyama; Kouki Inoue; Nobuo Kiriike; Kenji Torii; Hirotaka Ishizu; Etsushi Kawamura; Jin Kotani; Ai Oe; Takehiro Hayashi

    2004-01-01

    Purpose: Donepezil hydrochloride (Donepezil) is used clinically for the symptomatic treatment of dementia of Alzheimer type (DAT). DAT is characterized by progressive impairment of cognitive function and memory. associated with loss of presynaptic cholinergic function. Cholinergic agents such as cholinesterase inhibitors or cholinergic agonists are expected to have the potential to improve these symptoms. Donepezil is a piperidine-based acetylcholinesterase and acts by blocking cholinesterase. Donepezil can improve symptoms in patients with mild-to-moderate DAT and is not effective for all patients with DAT. Side effects such as nausea, vomiting and diarrhea sometimes occur with it. Estimation of therapeutic response to Donepezil before the start of treatment is anticipated. Brain perfusion single photon emission computed tomography (SPECT) is a functional imaging diagnosis method, and decrease in regional cerebral blood flow (rCBF) in brain regions affected by DAT is measured by SPECT. Visual diagnosis and quantitative analysis by region of interest (ROI) have been widely used as a conventional method for evaluation of brain SPECT images. ROI analysis has problems such as poor reproducibility and lack of objectivity in analysis of lesions randomly selected by operators, Recent methods of three-dimensional statistical imaging analysis such as statistical parametric mapping (SPM), three-dimensional stereotactic surface projection (3DSSP) and the easy Z-score imaging system (eZIS) have excellent in objectivity and reproducibility, due to automatic brain standardization and statistical processing of data from the entire brain. Their usefulness in detecting abnormalities in the brain of patients with DAT has been illustrated in many reports. SPM with voxel-by-voxel analysis using Student's unpaired t-test and paired t-test in the stereotactic space of the entire brain has high specificity but low sensitivity in detecting abnormalities. 3DSSP using Z-values has both

  15. Evidence of an association between 10/10 genotype of DAT1 and endophenotypes of attention deficit/hyperactivity disorder.

    Science.gov (United States)

    Agudelo, J A; Gálvez, J M; Fonseca, D J; Mateus, H E; Talero-Gutiérrez, C; Velez-Van-Meerbeke, A

    2015-04-01

    Genetic variance of attention deficit-hyperactivity disorder (ADHD) is a strong determinant of this disorder. The 40 base pairs (bp) variable number tandem repeat (VNTR) located in the 3' untranslated region (UTR) of DAT1 gene increases the expression of the dopamine transporter. Therefore, DAT1 has been associated with susceptibility to ADHD. To determine the association between the VNTR of DAT1 and the phenotype of ADHD or its endophenotypes in a sample of children aged between 6 and 15 years from Bogotá. We selected 73 patients with ADHD and 54 controls. WISC test was applied in all subjects and executive functions were assessed. The VNTR of DAT1 was polymerase chain reaction-amplified. Data regarding population genetics and statistical analysis were obtained. Correlation and association tests between genotype and neuropsychological testing were performed. The DAT1 polymorphism was not associated with ADHD (P=.85). Nevertheless, the 10/10 genotype was found to be correlated with the processing speed index (P<.05). In the hyperactivity subtype, there was a genotypic correlation with some subtests of executive function (cognitive flexibility) (P≤.01). In the combined subtype, the 10/10 genotype was associated with verbal comprehension index of WISC (P<.05). A correlation was found between DAT1 VNTR and the subtest "processing speed index" of WISC and the subtest "cognitive flexibility" of executive functions. To our knowledge, this is the first report to assess DAT1 gene in a Colombian population. Copyright © 2013 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved.

  16. Clinical use of regional Tc-99m-HMPAO uptake in dementia of the Alzheimer type (DAT). Klinische Wertigkeit des regionalen [sup 99m]Tc-HMPAO Uptake bei der Demenz vom Alzheimer-Typ (DAT)

    Energy Technology Data Exchange (ETDEWEB)

    Gebhardt, U [Nuklearmedizinische Klinik und Poliklinik, TU Muenchen (Germany); Schmauss, F [Nuklearmedizinische Klinik und Poliklinik, TU Muenchen (Germany); Wagner-Manslau, C [Nuklearmedizinische Klinik und Poliklinik, TU Muenchen (Germany); Buttermann, G [Nuklearmedizinische Klinik und Poliklinik, TU Muenchen (Germany); Zimmer, R [Psychiatrische Klinik, TU Muenchen (Germany)

    1993-12-01

    In 46 patients with dementia of the Alzheimer type (DAT) regional cerebral blood flow (rCBF) was compared with cognitive performance (MMSE, CAMCOG). The cortico-cerebellar ratio (CCR), determined by [sup 99m]Tc-HMPAO-SPECT was used as a rCBF-equivalent. In the mild demented group we found a bilateral CCR-reduction parietal posterior, in moderate DAT bilateral temporoparietal and leftsided frontolateral defects were seen. Severe DAT showed an additional perfusion decrease mid frontal. With increasing severity of DAT an asymmetric perfusion occurred in 17/46 patients with accentuated CCR-reduction on the left side (temporal>parietal). High correlations between CCR and MMSE (r[>=]0.70) existed frontolateral, temporal and parietal in the left hemisphere. Significant associations between CCR and CAMCOG were obtained for language in the left temporal posterior region (r=0.64), for memory task left temporal anterior (r=0.59) and for praxis left parietal posterior (r=0.55). In detecting rCBF abnormalities the sensitivity for all 46 DAT patients was 91% and 70% in the mild cases. (orig.)

  17. DRD4 and DAT1 in ADHD: Functional neurobiology to pharmacogenetics

    Directory of Open Access Journals (Sweden)

    Darko Turic

    2010-05-01

    Full Text Available Darko Turic1, James Swanson2, Edmund Sonuga-Barke1,31Institute for Disorders of Impulse and Attention, School of Psychology, University of Southampton, UK; 2Child Development Center, University of California, Irvine, California, US; 3Department of Experimental, Clinical and Health Psychology, Ghent University, BelgiumAbstract: Attention deficit/hyperactivity disorder (ADHD is a common and potentially very impairing neuropsychiatric disorder of childhood. Statistical genetic studies of twins have shown ADHD to be highly heritable, with the combination of genes and gene by environment interactions accounting for around 80% of phenotypic variance. The initial molecular genetic studies where candidates were selected because of the efficacy of dopaminergic compounds in the treatment of ADHD were remarkably successful and provided strong evidence for the role of DRD4 and DAT1 variants in the pathogenesis of ADHD. However, the recent application of noncandidate gene strategies (eg, genome-wide association scans has failed to identify additional genes with substantial genetic main effects, and the effects for DRD4 and DAT1 have not been replicated. This is the usual pattern observed for most other physical and mental disorders evaluated with current state-of-the-art methods. In this paper we discuss future strategies for genetic studies in ADHD, highlighting both the pitfalls and possible solutions relating to candidate gene studies, genome-wide studies, defining the phenotype, and statistical approaches.Keywords: dopamine, ADHD, pharmacogenetics, candidate gene

  18. S-phenylpiracetam, a selective DAT inhibitor, reduces body weight gain without influencing locomotor activity.

    Science.gov (United States)

    Zvejniece, Liga; Svalbe, Baiba; Vavers, Edijs; Makrecka-Kuka, Marina; Makarova, Elina; Liepins, Vilnis; Kalvinsh, Ivars; Liepinsh, Edgars; Dambrova, Maija

    2017-09-01

    S-phenylpiracetam is an optical isomer of phenotropil, which is a clinically used nootropic drug that improves physical condition and cognition. Recently, it was shown that S-phenylpiracetam is a selective dopamine transporter (DAT) inhibitor that does not influence norepinephrine (NE) or serotonin (5-HT) receptors. The aim of the present study was to study the effects of S-phenylpiracetam treatment on body weight gain, blood glucose and leptin levels, and locomotor activity. Western diet (WD)-fed mice and obese Zucker rats were treated daily with peroral administration of S-phenylpiracetam for 8 and 12weeks, respectively. Weight gain and plasma metabolites reflecting glucose metabolism were measured. Locomotor activity was detected in an open-field test. S-phenylpiracetam treatment significantly decreased body weight gain and fat mass increase in the obese Zucker rats and in the WD-fed mice. In addition, S-phenylpiracetam reduced the plasma glucose and leptin concentration and lowered hyperglycemia in a glucose tolerance test in both the mice and the rats. S-phenylpiracetam did not influence locomotor activity in the obese Zucker rats or in the WD-fed mice. The results demonstrate that S-phenylpiracetam reduces body weight gain and improves adaptation to hyperglycemia without stimulating locomotor activity. Our findings suggest that selective DAT inhibitors, such as S-phenylpiracetam, could be potentially useful for treating obesity in patients with metabolic syndrome with fewer adverse health consequences compared to other anorectic agents. Copyright © 2017. Published by Elsevier Inc.

  19. Effects of age and sex on 125I-β-CIT binding to DAT

    International Nuclear Information System (INIS)

    Liu Xingdang; Lin Xiangtong

    2000-01-01

    Objective: To investigate effects of age and sex on 125 I-β-CIT binding to dopamine transporter (DAT). Methods: Detection of the differences in 125 I-β-CIT binding kinetics in vivo between 6 week and 6 month old KM mice, and the differences of in vivo binding between female and male, and between 3 month and 12 month old SD rats.The animals were sacrificed 2 h after injection. Results: Uptake of 125 I-β-CIT in the striatum, frontal cortex, parietal cortex, temporal cortex, occipital cortex, hippocampus, brain stem and whole brain in 6 week old mice was higher than that in 6 month old mice, and similar uptake pattern happened in between 3 month old and in 12 month old SD rats. In 12 months old SD rats, female rats had higher uptake in the striatum than male rats did. Conclusions: Young mice and rats have a higher uptake of 125 I-β-CIT in the striatum than aged ones and female rats have a higher uptake than male ones do. This result indicates that the density of DAT in rat or mouse striatum may be reduced with aging

  20. Mikrotransakce a jejich použití v českém prostředí

    OpenAIRE

    Žitník, Martin

    2011-01-01

    Tato bakalářská práce se zaměřuje na využití elektronických platebních systému pro účely řešení mikrotransakcí na území české republiky. Součástí práce je analýza takovýchto systémů v kontextu českého prostředí, vycházející z teoretických poznatků o jejich vlastnostech a rozděleních. Výsledkem je návrh řešení použití elektronických platebních systémů pro mikrotransakce na typových případech. This bachelor thesis is focused on usage of electronic payment systems for microtransaction in Czec...

  1. Clinical use of regional Tc-99m-HMPAO uptake in dementia of the Alzheimer type (DAT)

    International Nuclear Information System (INIS)

    Gebhardt, U.; Schmauss, F.; Wagner-Manslau, C.; Buttermann, G.; Zimmer, R.

    1993-01-01

    In 46 patients with dementia of the Alzheimer type (DAT) regional cerebral blood flow (rCBF) was compared with cognitive performance (MMSE, CAMCOG). The cortico-cerebellar ratio (CCR), determined by 99m Tc-HMPAO-SPECT was used as a rCBF-equivalent. In the mild demented group we found a bilateral CCR-reduction parietal posterior, in moderate DAT bilateral temporoparietal and leftsided frontolateral defects were seen. Severe DAT showed an additional perfusion decrease mid frontal. With increasing severity of DAT an asymmetric perfusion occurred in 17/46 patients with accentuated CCR-reduction on the left side (temporal>parietal). High correlations between CCR and MMSE (r≥0.70) existed frontolateral, temporal and parietal in the left hemisphere. Significant associations between CCR and CAMCOG were obtained for language in the left temporal posterior region (r=0.64), for memory task left temporal anterior (r=0.59) and for praxis left parietal posterior (r=0.55). In detecting rCBF abnormalities the sensitivity for all 46 DAT patients was 91% and 70% in the mild cases. (orig.) [de

  2. Toward unified ice core chronologies with the DatIce tool

    Science.gov (United States)

    Toye Mahamadou Kele, H.; Lemieux-Dudon, B.; Blayo, E.

    2012-04-01

    Antarctic and Greenland ice cores provide a means to study the phase relationships of climate changes in both hemispheres. They also enable to study the timing between climate, and greenhouse gases or orbital forcings. One key step for such studies is to improve the absolute and relative precisions of ice core age scales (for ice and trapped gas), and beyond that, to try to reach the best consistency between chronologies of paleo records of any kind. The DatIce tool is designed to increase the consistency between pre-existing (also called background) core chronologies. It formulates a variational inverse problem which aims at correcting three key quantities that uniquely define the core age scales: the accumulation rate, the total thinning function, and the close-off depth. For that purpose, it integrates paleo data constraints of many types among which age markers (with for instance documented volcanoes eruptions), and stratigraphic links (with for instance abrupt changes in methane concentration). A cost function is built that enables to calculate new chronologies by making a trade-off between all the constraints (background chronologies and paleo data). The method presented in Lemieux-Dudon et al (2010) has already been applied simultaneously to EPICA EDML and EDC, Vostok and NGRIP. Currently, on going works are conducted at LSCE Saclay and LGGE Grenoble laboratories to construct unified Antarctic chronologies by applying the DatIce tool with new ice cores and new sets of paleo measurements. We here present the DatIce tool, the underlying methodology, and its potential applications. We further show some improvements that have been made recently. We especially adress the issue related to the calibration of the error of pre-existing core chronologies. They are inputs that may have a strong impact on the results. However these uncertainties are uneasy to analyze, since prior chronologies are most of the time assessed on the basis of glaciological models (firn

  3. Georeferencing natural disaster impact footprints : lessons learned from the EM-DAT experience

    Science.gov (United States)

    Wallemacq, Pascaline; Guha Sapir, Debarati

    2014-05-01

    The Emergency Events Database (EM-DAT) contains data about the occurrence and consequences of all the disasters that have taken place since 1900. The main objectives of the database are to serve the purposes of humanitarian action at national and international levels; to aid decision making for disaster preparedness, as well as providing an objective base for vulnerability assessments and priority setting. EM-DAT records data on the human and economic impacts for each event as well as the location of said event. This is recorded as text data, namely the province, department, county, district, or village. The first purpose of geocoding (or georeferencing) the EM-DAT database is to transform the location data from text format into code data. The GAUL (Global Administrative Unit Layers) database (FAO) is used as a basis to identify the geographic footprint of the disaster, ideally to the second administrative level and add a unique code for each affected unit. Our first step has involved georeferencing earthquakes since the location of these is precise. The second purpose is to detail the degree of precision of georeferencing. The application and benefits of georeferencing are manifold. The geographic information of the footprint of past (after 2000) and future natural disasters permits the location of vulnerable areas with a GIS system and to cross data from different sources. It will allow the study of different elements such as the extent of a disaster and its human and economic consequences; the exposure and vulnerability of the population in space and time and the efficiency of mitigation measures. In addition, any association between events and external factors can be identified (e.g.: is the famine located at the same places as drought?) and precision of the information in the disaster report can be evaluated. Besides this, these maps will provide valuable communication support since maps have a high communication power and are easily understandable by the

  4. Přehled pokročilých technik rapid prototyping a jejich využití ve slévárenství

    OpenAIRE

    Drda, Jan

    2012-01-01

    Tato práce se zabývá přehledem metod rapid prototyping a jejich možností uplatnění ve slévárenství. Je rozdělena do tří částí. V první je uvedeno, jakým postupem se obecně vytvoří model pomocí technologie rapid prototyping. Ve druhé části je vytvořen přehled metod, které se používají ve světě. Je rozdělena na tři menší části, které představují základní dělení metod. Jsou zde uvedeny základní principy metod, jejich výhody, nevýhody a použití. V poslední části je představeno shrnutí současného ...

  5. EuReDatA - project groups: An overview of objectives and results

    International Nuclear Information System (INIS)

    Luisi, T.

    1986-01-01

    The EuReDatA Association was formed to harmonize research and development work in the field of Reliability Data Banks, in particular by promoting the adoption of agreed definitions and procedures aimed at the exchange of information and experience on reliability data acquisition among members. To solve the problems arising from the organization and control of the large effort various ad-hoc project groups were created to work out solutions for specific topics. This paper describes the effort made and the results obtained by such specialized groups which have already produced reports that could be utilized by people active in an ever-widening variety of disciplines to facilitate the useful exchange of reliability information among them. (orig./DG)

  6. Blow capacity of an air curtain; Hoe hard denkt u dat een luchtgrodijn moet blazen?

    Energy Technology Data Exchange (ETDEWEB)

    Cremers, B.E. [Biddle, Kootstertille (Netherlands)

    2003-03-01

    In winter, the heat capacity of a conventional air curtain can often be increased by adjusting the speed of its outlet velocity. This article demonstrates that for various reasons, it is better to adjust the width of the outlet if you need to boost the heat level rather than the outlet velocity. It also describes the benefits of this CA (Constant Air Velocity) Technology in the interests of energy conservation and comfort. [Dutch] In de winter wordt de warmtecapaciteit van een conventioneel luchtgordijn vaak verhoogd door de uitblaassnelheid aan te passen. Dit artikel toont aan dat het om meerdere redenen beter is om bij een hogere warmtebehoefte de uitblaasbreedte aan te passen in plaats van de uitblaassnelheid. Daarnaast beschrijft het de voordelen van deze CA-technologie (Constant Air velocity) wat betreft energieverbruik en comfort.

  7. Dog-Assisted Therapy (DAT Applied to Children with Autism Spectrum Disorder (ASD in School Age

    Directory of Open Access Journals (Sweden)

    María Dolores Jara-Gil

    2017-11-01

    Full Text Available With this study and through an extensive literature review, firstly, it tries to bring the reader to the field of Autism Spectrum Disorder (ASD and the Animal-Assisted Therapy (AAT, which are novel therapeutic alternative very effective and applicable to both children, young people and adults, whether in the academic, social as in the clinical field. Secondly, this work goes after to demonstrate the therapeutic effects that are obtained when we applying a AAT, in this case, a Dog-Assisted Therapy (DAT on children with ASD, and to demonstrate that it can be used as a complement to any type of treatment, be outlined the great and unknown importance in the lives of whom suffer from this disorder, besides to improve the different areas of the ASD and to demonstrate the extensive benefits, contributions and improvements that dogs are capable to produce.

  8. A global historical data set of tropical cyclone exposure (TCE-DAT)

    Science.gov (United States)

    Geiger, Tobias; Frieler, Katja; Bresch, David N.

    2018-01-01

    Tropical cyclones pose a major risk to societies worldwide, with about 22 million directly affected people and damages of USD 29 billion on average per year over the last 20 years. While data on observed cyclones tracks (location of the center) and wind speeds are publicly available, these data sets do not contain information about the spatial extent of the storm and people or assets exposed. Here, we apply a simplified wind field model to estimate the areas exposed to wind speeds above 34, 64, and 96 knots (kn). Based on available spatially explicit data on population densities and gross domestic product (GDP) we estimate (1) the number of people and (2) the sum of assets exposed to wind speeds above these thresholds accounting for temporal changes in historical distribution of population and assets (TCE-hist) and assuming fixed 2015 patterns (TCE-2015). The associated spatially explicit and aggregated country-event-level exposure data (TCE-DAT) cover the period 1950 to 2015 and are freely available at https://doi.org/10.5880/pik.2017.011 (Geiger at al., 2017c). It is considered key information to (1) assess the contribution of climatological versus socioeconomic drivers of changes in exposure to tropical cyclones, (2) estimate changes in vulnerability from the difference in exposure and reported damages and calibrate associated damage functions, and (3) build improved exposure-based predictors to estimate higher-level societal impacts such as long-term effects on GDP, employment, or migration. We validate the adequateness of our methodology by comparing our exposure estimate to estimated exposure obtained from reported wind fields available since 1988 for the United States. We expect that the free availability of the underlying model and TCE-DAT will make research on tropical cyclone risks more accessible to non-experts and stakeholders.

  9. Dat is wel eens anders geweest!’ Geschiedenis op de Nederlandse televisie

    Directory of Open Access Journals (Sweden)

    Paul Knevel

    2015-03-01

    Full Text Available It was Different Then!: History on Dutch TelevisionIn ‘Dat is wel eens anders geweest!’ [It was different then!] Paul Knevel and Jouke Turpijn attempt to provide tools for historians to analyse history on the television in a broad historiographical perspective. They cover the first history productions in the Netherlands and the remarkable success of major series in the twentyfirst century. The difficult relation between academic and public history on the television in the Netherlands is placed in an international context. De Gouden Eeuw [The Golden Age] serves as a case study to investigate history series. While De Gouden Eeuw was a big success, it also demonstrates certain limits to Dutch history productions. In ‘Dat is wel eens anders geweest!’ reiken Paul Knevel en Jouke Turpijnhandvatten aan om geschiedenis op televisie in een breed histori(ografisch perspectief te duiden. Vertrekkend vanaf de eerste producties bespreken zij het wonderbaarlijke succes van geschiedenisseries in de eenentwintigste eeuw. Zij staan stil bij de moeizame relatie in Nederland tussen academische geschiedenis en geschiedenis op televisie en vergelijken dit met andere landen. Daarna analyseren zij de serie De Gouden Eeuw, die enerzijds het beste in het genre naar boven heeft gehaald in termen van kijkcijfers, de multimediale aanpak en het evoceren van een ver voorbij verleden. Anderzijds roepen deze en eerdere series de vraag op of er niet iets te winnen valt met andere presentatievormen, waarbij een alwetende presentator misschien wel meer kennis- en visie-overdracht oplevert dan de in Nederland gebruikelijkere presentator die alles wil weten.

  10. DAT1-Genotype and Menstrual Cycle, but Not Hormonal Contraception, Modulate Reinforcement Learning: Preliminary Evidence.

    Science.gov (United States)

    Jakob, Kristina; Ehrentreich, Hanna; Holtfrerich, Sarah K C; Reimers, Luise; Diekhof, Esther K

    2018-01-01

    Hormone by genotype interactions have been widely ignored by cognitive neuroscience. Yet, the dependence of cognitive performance on both baseline dopamine (DA) and current 17ß-estradiol (E2) level argues for their combined effect also in the context of reinforcement learning. Here, we assessed how the interaction between the natural rise of E2 in the late follicular phase (FP) and the 40 base-pair variable number tandem repeat polymorphism of the dopamine transporter (DAT1) affects reinforcement learning capacity. 30 women with a regular menstrual cycle performed a probabilistic feedback learning task twice during the early and late FP. In addition, 39 women, who took hormonal contraceptives (HC) to suppress natural ovulation, were tested during the "pill break" and the intake phase of HC. The present data show that DAT1-genotype may interact with transient hormonal state, but only in women with a natural menstrual cycle. We found that carriers of the 9-repeat allele (9RP) experienced a significant decrease in the ability to avoid punishment from early to late FP. Neither homozygote subjects of the 10RP allele, nor subjects from the HC group showed a change in behavior between phases. These data are consistent with neurobiological studies that found that rising E2 may reverse DA transporter function and could enhance DA efflux, which would in turn reduce punishment sensitivity particularly in subjects with a higher transporter density to begin with. Taken together, the present results, although based on a small sample, add to the growing understanding of the complex interplay between different physiological modulators of dopaminergic transmission. They may not only point out the necessity to control for hormonal state in behavioral genetic research, but may offer new starting points for studies in clinical settings.

  11. DAT1-Genotype and Menstrual Cycle, but Not Hormonal Contraception, Modulate Reinforcement Learning: Preliminary Evidence

    Directory of Open Access Journals (Sweden)

    Kristina Jakob

    2018-02-01

    Full Text Available Hormone by genotype interactions have been widely ignored by cognitive neuroscience. Yet, the dependence of cognitive performance on both baseline dopamine (DA and current 17ß-estradiol (E2 level argues for their combined effect also in the context of reinforcement learning. Here, we assessed how the interaction between the natural rise of E2 in the late follicular phase (FP and the 40 base-pair variable number tandem repeat polymorphism of the dopamine transporter (DAT1 affects reinforcement learning capacity. 30 women with a regular menstrual cycle performed a probabilistic feedback learning task twice during the early and late FP. In addition, 39 women, who took hormonal contraceptives (HC to suppress natural ovulation, were tested during the “pill break” and the intake phase of HC. The present data show that DAT1-genotype may interact with transient hormonal state, but only in women with a natural menstrual cycle. We found that carriers of the 9-repeat allele (9RP experienced a significant decrease in the ability to avoid punishment from early to late FP. Neither homozygote subjects of the 10RP allele, nor subjects from the HC group showed a change in behavior between phases. These data are consistent with neurobiological studies that found that rising E2 may reverse DA transporter function and could enhance DA efflux, which would in turn reduce punishment sensitivity particularly in subjects with a higher transporter density to begin with. Taken together, the present results, although based on a small sample, add to the growing understanding of the complex interplay between different physiological modulators of dopaminergic transmission. They may not only point out the necessity to control for hormonal state in behavioral genetic research, but may offer new starting points for studies in clinical settings.

  12. EXO-DAT: AN INFORMATION SYSTEM IN SUPPORT OF THE CoRoT/EXOPLANET SCIENCE

    International Nuclear Information System (INIS)

    Deleuil, M.; Meunier, J. C.; Moutou, C.; Surace, C.; Barbieri, M.; Agneray, F.; Granet, Y.; Guterman, P.; Deeg, H. J.; Almenara, J. M.; Debosscher, J.; Hodgkin, S.

    2009-01-01

    Exo-Dat is a database and an information system created primarily in support of the exoplanet program of the COnvection ROtation and planetary Transits (CoRoT) mission. In the directions of CoRoT pointings, it provides a united interface to several sets of data: stellar published catalogs, photometric and spectroscopic data obtained during the mission preparation, results from the mission and from follow-up observations, and several mission-specific technical parameters. The new photometric data constitute the subcatalog Exo-Cat, and give consistent 4-color photometry of 14.0 million stars with a completeness to 19th magnitude in the r-filter. It covers several zones in the galactic plane around CoRoT pointings, with a total area of 209 deg 2 . This Exo-Dat information system provides essential technical support to the ongoing CoRoT light-curve analyses and ground-based follow-up by supplying additional complementary information such as the prior knowledge of the star's fundamental parameters or its contamination level inside the large CoRoT photometric mask. The database is fully interfaced with VO tools and thus benefits from existing visualization and analysis tools like TOPCAT or ALADIN. It is accessible to the CoRoT community through the Web, and will be gradually opened to the public. It is the ideal tool to prepare the foreseen statistical studies of the properties of the exoplanetary systems. As a VO-compliant system, such analyses could thus benefit from the most up-to-date classifier tools.

  13. Invloed van UV straling in de kas. Fors minder plaaginsecten bij kasdek dat geen UV-licht doorlaat

    NARCIS (Netherlands)

    Hemming, S.; Os, van E.

    2007-01-01

    Nieuwe energiebesparende kasdekmaterialen hebben een andere doorlatendheid voor UV-straling dan glas. Dat heeft niet alleen invloed op de groei van planten, maar ook op die van plaaginsecten, schimmels, predatoren en bestuivende insecten. In dit artikel komt het effect van UV op plaaginsecten,

  14. Automatic semi-quantification of [123I]FP-CIT SPECT scans in healthy volunteers using BasGan version 2: results from the ENC-DAT database

    NARCIS (Netherlands)

    Nobili, Flavio; Naseri, Mehrdad; de Carli, Fabrizio; Asenbaum, Susan; Booij, Jan; Darcourt, Jacques; Ell, Peter; Kapucu, Ozlem; Kemp, Paul; Svarer, Claus; Varer, Claus; Morbelli, Silvia; Pagani, Marco; Sabri, Osama; Tatsch, Klaus; Tossici-Bolt, Livia; Sera, Terez; Vander Borght, Tierry; van Laere, Koen; Varrone, Andrea

    2013-01-01

    The aim of this study was to assess striatal dopamine transporter (DAT) availability in a large group of normal subjects. The study included 122 healthy subjects, aged 18-83 years, recruited in the multicentre 'ENC-DAT' study (promoted by the European Association of Nuclear Medicine). Brain single

  15. Effects of hypoxic–ischemic brain injury on striatal dopamine transporter in newborn piglets: evaluation of 11C-CFT PET/CT for DAT quantification

    International Nuclear Information System (INIS)

    Zhang Yanfen; Wang Xiaoyu; Cao Li; Guo Qiyong; Wang Xiaoming

    2011-01-01

    Introduction: Alterations of dopamine in striatal presynaptic terminals play an important role in the hypoxic–ischemic (HI) brain injury. Quantification of DAT levels in the presynaptic site using 11 C-N-2-carbomethoxy-3-(4-fluorophenyl)-tropane ( 11 C-CFT) with positron emission tomography (PET) was applied in studies for Parkinson's disease. The current study investigated the changes in striatal DAT following HI brain injury in newborn piglets using 11 C-CFT PET. Methods: Newborn piglets were subjected to occlusion of bilateral common carotid arteries for 30 min and simultaneous peripheral hypoxia. Brain DAT imaging was performed using PET/CT with 11 C-CFT as the probe in each group (including the control group and HI insult groups). Brain tissues were collected for DAT immunohistochemical (IHC) analysis at each time point post the PET/CT procedure. Sham controls had some operation without HI procedure. Results: A few minutes after intravenous injection of 11 C-CFT, radioactive signals for DAT clearly appeared in the cortical area, striatum and cerebellum of newborn piglets of sham control group and HI insult groups. HI brain insult markedly increased striatal DAT at an early period (P 11 C-CFT PET imaging data and IHC DAT staining data were highly correlated (r=0.844, P 11 C-CFT PET/CT imaging data reflected the dynamic changes of DAT in the striatum in vivo.

  16. Effect of scopolamine on central DAT and D2 receptor in morphine dependent rats

    International Nuclear Information System (INIS)

    Lin Yansong; Wang Shizhen; Ding Shiyu; Chen Zhenping; Zhou Xiang; Fang Ping; Wang Bocheng

    2004-01-01

    Objective: To investigate the effect of scopolamine (Sco) on central dopamine transporter (DAT) and D 2 receptor in morphine (Mor) dependent rats. Methods: Chronic Mor exposure was induced by repeated Mor (20 mg·kg -1 ·d -1 , i.p.) treatment for 8 d. Conditioned place preference test was used to evaluate the drug seeking behavior. Biodistribution of the imaging agents 125 I-2β-carbomethoxy-3β-(4-iodophenyl) tropane (β-CIT) and 125 I-3-iodo-2-hydroxy-6-methoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl] benzamide (IBZM) were used to evaluate the central DAT and D 2 receptor during chronic Mor exposure. Results: For the Mor plus pretreating with Sco (Mor+Sco) rats, the time for the rats entering C2 from C1 was (1.72 ± 0.69) min in the first day, with little difference from the control and Mor group (P>0.05), and (1.12 ± 0.33) min for the 8th day, still longer than that of the Mor group (t=5.171, P 125 I-β- CIT %ID/g in striatum (ST) and nucleus accumbens (NAC) for Mor + Sco group were 3.307 ± 0.189 and 1.577 ± 0.401 respectively, higher than those of the control group (2.431 ± 0.104, 1.441 ± 0.043, t was 4.151 and 5.416 respectively, P 125 I-IBZM %ID/g in ST, NAC, hippocampus (HIP) and frontal cortex (FC) for Mor + Sco group were 0.589 ± 0.081, 0.683 ± 0.046, 0.175 ± 0.039 and 0.257 ± 0.034 lower than that of the control rats (0.735 ± 0.096, 0.709 ± 0.098, 0.281 ± 0.038, 0.289 ± 0.020, t was 7.841, 6.170, 5.446 and 4.337 respectively, P 2 receptor induced by Mor to some extent

  17. ERK mediated upregulation of death receptor 5 overcomes the lack of p53 functionality in the diaminothiazole DAT1 induced apoptosis in colon cancer models: efficiency of DAT1 in Ras-Raf mutated cells.

    Science.gov (United States)

    Thamkachy, Reshma; Kumar, Rohith; Rajasekharan, K N; Sengupta, Suparna

    2016-03-08

    p53 is a tumour suppressor protein that plays a key role in many steps of apoptosis, and malfunctioning of this transcription factor leads to tumorigenesis. Prognosis of many tumours also depends upon the p53 status. Most of the clinically used anticancer compounds activate p53 dependent pathway of apoptosis and hence require p53 for their mechanism of action. Further, Ras/Raf/MEK/ERK axis is an important signaling pathway activated in many cancers. Dependence of diaminothiazoles, compounds that have gained importance recently due to their anticancer and anti angiogenic activities, were tested in cancer models with varying p53 or Ras/Raf mutational status. In this study we have used p53 mutated and knock out colon cancer cells and xenograft tumours to study the role of p53 in apoptosis mediated by diaminothiazoles. Colon cancer cell lines with varying mutational status for Ras or Raf were also used. We have also examined the toxicity and in vivo efficacy of a lead diaminothiazole 4-Amino-5-benzoyl-2-(4-methoxy phenylamino)thiazole (DAT1) in colon cancer xenografts. We have found that DAT1 is active in both in vitro and in vivo models with nonfunctional p53. Earlier studies have shown that extrinsic pathway plays major role in DAT1 mediated apoptosis. In this study, we have found that DAT1 is causing p53 independent upregulation of the death receptor 5 by activating the Ras/Raf/MEK/ERK signaling pathway both in wild type and p53 suppressed colon cancer cells. These findings are also confirmed by the in vivo results. Further, DAT1 is more efficient to induce apoptosis in colon cancer cells with mutated Ras or Raf. Minimal toxicity in both acute and subacute studies along with the in vitro and in vivo efficacy of DAT1 in cancers with both wild type and nonfunctional p53 place it as a highly beneficial candidate for cancer chemotherapy. Besides, efficiency in cancer cells with mutations in the Ras oncoprotein or its downstream kinase Raf raise interest in

  18. DAT1 polymorphism determines L-DOPA effects on learning about others' prosociality.

    Directory of Open Access Journals (Sweden)

    Christoph Eisenegger

    Full Text Available Despite that a wealth of evidence links striatal dopamine to individualś reward learning performance in non-social environments, the neurochemical underpinnings of such learning during social interaction are unknown. Here, we show that the administration of 300 mg of the dopamine precursor L-DOPA to 200 healthy male subjects influences learning about a partners' prosocial preferences in a novel social interaction task, which is akin to a repeated trust game. We found learning to be modulated by a well-established genetic marker of striatal dopamine levels, the 40-bp variable number tandem repeats polymorphism of the dopamine transporter (DAT1 polymorphism. In particular, we found that L-DOPA improves learning in 10/10R genoype subjects, who are assumed to have lower endogenous striatal dopamine levels and impairs learning in 9/10R genotype subjects, who are assumed to have higher endogenous dopamine levels. These findings provide first evidence for a critical role of dopamine in learning whether an interaction partner has a prosocial or a selfish personality. The applied pharmacogenetic approach may open doors to new ways of studying psychiatric disorders such as psychosis, which is characterized by distorted perceptions of others' prosocial attitudes.

  19. Drivers of coastal shoreline change: case study of hon dat coast, Kien Giang, Vietnam.

    Science.gov (United States)

    Nguyen, Hai-Hoa; McAlpine, Clive; Pullar, David; Leisz, Stephen Joseph; Galina, Gramotnev

    2015-05-01

    Coastal shorelines are naturally dynamic, shifting in response to coastal geomorphological processes. Globally, land use change associated with coastal urban development and growing human population pressures is accelerating coastal shoreline change. In southern Vietnam, coastal erosion currently is posing considerable risks to shoreline land use and coastal inhabitants. The aim of this paper is to quantify historical shoreline changes along the Hon Dat coast between 1995 and 2009, and to document the relationships between coastal mangrove composition, width and density, and rates of shoreline change. The generalized linear mixed-effects models were used to quantify the major biophysical and land-use factors influencing shoreline change rates. Most significant drivers of the rates of change are cutting of mangroves, the dominant mangrove genus, changes in adjacent shoreline land use, changes of shoreline land cover, and width of fringing mangroves. We suggest that a possible and inexpensive strategy for robust mangrove shoreline defense is direct mangrove planting to promote mangrove density with the presence of breakwater structures. In the shorter term, construction of coastal barriers such as fence-structured melaleuca poles in combination with mangrove restoration schemes could help retain coastal sediments and increase the elevation of the accretion zone, thereby helping to stabilize eroding fringe shorelines. It also is recommended that implementation of a system of payments for mangrove ecosystem services and the stronger regulation of mangrove cutting and unsustainable land-use change to strengthen the effectiveness of mangrove conservation programs and coastal land-use management.

  20. Drivers of Coastal Shoreline Change: Case Study of Hon Dat Coast, Kien Giang, Vietnam

    Science.gov (United States)

    Nguyen, Hai-Hoa; McAlpine, Clive; Pullar, David; Leisz, Stephen Joseph; Galina, Gramotnev

    2015-05-01

    Coastal shorelines are naturally dynamic, shifting in response to coastal geomorphological processes. Globally, land use change associated with coastal urban development and growing human population pressures is accelerating coastal shoreline change. In southern Vietnam, coastal erosion currently is posing considerable risks to shoreline land use and coastal inhabitants. The aim of this paper is to quantify historical shoreline changes along the Hon Dat coast between 1995 and 2009, and to document the relationships between coastal mangrove composition, width and density, and rates of shoreline change. The generalized linear mixed-effects models were used to quantify the major biophysical and land-use factors influencing shoreline change rates. Most significant drivers of the rates of change are cutting of mangroves, the dominant mangrove genus, changes in adjacent shoreline land use, changes of shoreline land cover, and width of fringing mangroves. We suggest that a possible and inexpensive strategy for robust mangrove shoreline defense is direct mangrove planting to promote mangrove density with the presence of breakwater structures. In the shorter term, construction of coastal barriers such as fence-structured melaleuca poles in combination with mangrove restoration schemes could help retain coastal sediments and increase the elevation of the accretion zone, thereby helping to stabilize eroding fringe shorelines. It also is recommended that implementation of a system of payments for mangrove ecosystem services and the stronger regulation of mangrove cutting and unsustainable land-use change to strengthen the effectiveness of mangrove conservation programs and coastal land-use management.

  1. A 40-bp VNTR polymorphism in the 3'-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism.

    Science.gov (United States)

    Šerý, Omar; Paclt, Ivo; Drtílková, Ivana; Theiner, Pavel; Kopečková, Marta; Zvolský, Petr; Balcar, Vladimir J

    2015-06-11

    ADHD and alcoholism are psychiatric diseases with pathophysiology related to dopamine system. DAT1 belongs to the SLC6 family of transporters and is involved in the regulation of extracellular dopamine levels. A 40 bp variable number tandem repeat (VNTR) polymorphism in the 3'-untranslated region of DAT1/SLC6A3 gene was previously reported to be associated with various phenotypes involving disturbed regulation of dopaminergic neurotransmission. A total of 1312 subjects were included and genotyped for 40 bp VNTR polymorphism of DAT1/SLC6A3 gene in this study (441 alcoholics, 400 non-alcoholic controls, 218 ADHD children and 253 non ADHD children). Using miRBase software, we have performed a computer analysis of VNTR part of DAT1 gene for presence of miRNA binding sites. We have found significant relationships between ADHD and the 40 bp VNTR polymorphisms of DAT1/SLC6A3 gene (P VNTR polymorphism of DAT1/SLC6A3 gene has been detected. We have found an association between 40 bp VNTR polymorphism of DAT1/SLC6A3 gene and ADHD in the Czech population; in a broad agreement with studies in other population samples. Furthermore, we detected rare genotypes 8/10, 7/10 and 10/11 present in ADHD boys only and identified miRNAs that should be looked at as potential novel targets in the research on ADHD.

  2. XMuDat: Photon attenuation data on PC. Version 1.0.1 of August 1998. Summary documentation

    International Nuclear Information System (INIS)

    Pronyaev, V.G.

    1998-01-01

    XMuDat is a program to be used with Windows 95 or Windows NT for the presentation and calculation of various photon interaction coefficients. Six absorbing materials can be set up individually. Each material can be composed of components chosen from the elements and further from a number of compounds and mixtures of dosimetric interest. Data for mass attenuation-, mass energy transfer- and mass energy absorption coefficients in a photon energy range of 1 keV to 50 MeV can be retrieved. A set of two diskettes with XMuDat files is available upon request, costfree, from the IAEA Nuclear Data Section. Users with access to Internet may download xmudat.zip file (1,174 KB) from http://www.nds.iaea.or.at/reports/nds-195.htm. (author)

  3. Applicability of direct agglutination test (DAT) at a rural health setting in Bangladesh and feasibility of local antigen production.

    Science.gov (United States)

    Chowdhury, M S; al Masum, A; al Karim, E; Semiáo-Santos, S; Rahman, K M; Ar-Rashid, H; el Harith, A

    1993-01-01

    As part of a large-scale sero-epidemiological survey on visceral leishmaniasis (VL) carried out in Mymensingh district of Bangladesh, applicability of DAT was assessed at the level of a rural health setting in Trishal (upazila) subdistrict. Despite the relatively less optimal conditions encountered, 5854 inhabitants from 7 villages appendant to Trishal were assessed for VL. The demographic distribution for sero-positivity obtained at the rural setting was comparable to that found by DAT as executed at the central laboratory (IEDC&R, Dhaka) on 9619 inhabitants from the same upazila. The overall sero-prevalence rate was 4.4% compared to 3.7% obtained in the population assessed at the central laboratory. In either study, similar VL prevalence rates of 2.1% were obtained in the male populations. Irrespective of sex, younger population ( or = 90 years (1.4% and 1.8%). Local production of DAT antigen employing an authochtonus L. donovani isolate was attempted at the central laboratory (IEDC&R) in Dhaka. By comparison with the reference antigen, titres obtained in all 33 VL sera tested were equally higher (1:6400- > or =: 51200) than in 35 out of 38 negative controls (< or = 1:400-1:1600). A comparable level of reactivity was also obtained in 53 VL and 52 negative control sera using a well characterized L. donovani strain (MHOM/IN/80/D88) from India. However, unlike the reference strain, titres obtained in 7 endemic controls were significantly higher with the authochtonous and homologous antigen (1:3200 - 1:6400) than with the reference (1:100 - 1:1600). The results signify the advantage of employing indigenous L. donovani isolates to further improve DAT sensitivity for detection of early and sub-clinical VL.

  4. Utility of the combination of DAT SPECT and MIBG myocardial scintigraphy in differentiating dementia with Lewy bodies from Alzheimer's disease

    International Nuclear Information System (INIS)

    Shimizu, Soichiro; Hirao, Kentaro; Kanetaka, Hidekazu; Namioka, Nayuta; Hatanaka, Hirokuni; Hirose, Daisuke; Fukasawa, Raita; Umahara, Takahiko; Sakurai, Hirohumi; Hanyu, Haruo

    2016-01-01

    123 I-2β-Carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane ( 123 I-FP-CIT) dopamine transporter single photon emission computed tomography (DAT SPECT) and 123 I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy can be used to assist in the diagnosis of patients with dementia with Lewy bodies (DLB). We compared the diagnostic value of these two methods in differentiating DLB from Alzheimer's disease (AD). Furthermore, we evaluated whether a combination of DAT SPECT and MIBG myocardial scintigraphy would provide a more useful means of differentiating between DLB and AD. Patients with AD (n = 57) and patients with DLB (n = 76) who underwent both DAT SPECT and MIBG myocardial scintigraphy were enrolled. The sensitivity, specificity, and accuracy of both methods as well as their combination for differentiating DLB from AD were calculated. Moreover, we examined whether symptoms of the patients with DLB were associated with the patterns of the abnormalities displayed on DAT SPECT and MIBG myocardial scintigraphy. The sensitivity and specificity of differentiating DLB from AD were 72.4 and 94.4 % by the heart to mediastinum ratio of MIBG uptake, 88.2 and 88.9 % by the specific binding ratio on DAT SPECT, and 96.1 and 90.7 % by their combination, respectively. The combined use of DAT SPECT and MIBG myocardial scintigraphy enabled more accurate differentiation between DLB and AD compared with either DAT SPECT or MIBG myocardial scintigraphy alone. There was a significantly higher frequency of parkinsonism in the abnormal DAT SPECT group than the normal DAT SPECT group. On the other hand, there was a higher frequency of the appearance of rapid eye movement (REM) sleep behavior disorder in the abnormal MIBG uptake group than the normal MIBG uptake group. These results suggested that using a combination of these scintigraphic methods is a useful and practical approach to differentiate DLB from AD. (orig.)

  5. Utility of the combination of DAT SPECT and MIBG myocardial scintigraphy in differentiating dementia with Lewy bodies from Alzheimer's disease

    Energy Technology Data Exchange (ETDEWEB)

    Shimizu, Soichiro; Hirao, Kentaro; Kanetaka, Hidekazu; Namioka, Nayuta; Hatanaka, Hirokuni; Hirose, Daisuke; Fukasawa, Raita; Umahara, Takahiko; Sakurai, Hirohumi; Hanyu, Haruo [Tokyo Medical University, Department of Geriatric Medicine, Shinjuku-ku, Tokyo (Japan)

    2016-01-15

    {sup 123}I-2β-Carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane ({sup 123}I-FP-CIT) dopamine transporter single photon emission computed tomography (DAT SPECT) and {sup 123}I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy can be used to assist in the diagnosis of patients with dementia with Lewy bodies (DLB). We compared the diagnostic value of these two methods in differentiating DLB from Alzheimer's disease (AD). Furthermore, we evaluated whether a combination of DAT SPECT and MIBG myocardial scintigraphy would provide a more useful means of differentiating between DLB and AD. Patients with AD (n = 57) and patients with DLB (n = 76) who underwent both DAT SPECT and MIBG myocardial scintigraphy were enrolled. The sensitivity, specificity, and accuracy of both methods as well as their combination for differentiating DLB from AD were calculated. Moreover, we examined whether symptoms of the patients with DLB were associated with the patterns of the abnormalities displayed on DAT SPECT and MIBG myocardial scintigraphy. The sensitivity and specificity of differentiating DLB from AD were 72.4 and 94.4 % by the heart to mediastinum ratio of MIBG uptake, 88.2 and 88.9 % by the specific binding ratio on DAT SPECT, and 96.1 and 90.7 % by their combination, respectively. The combined use of DAT SPECT and MIBG myocardial scintigraphy enabled more accurate differentiation between DLB and AD compared with either DAT SPECT or MIBG myocardial scintigraphy alone. There was a significantly higher frequency of parkinsonism in the abnormal DAT SPECT group than the normal DAT SPECT group. On the other hand, there was a higher frequency of the appearance of rapid eye movement (REM) sleep behavior disorder in the abnormal MIBG uptake group than the normal MIBG uptake group. These results suggested that using a combination of these scintigraphic methods is a useful and practical approach to differentiate DLB from AD. (orig.)

  6. Crystallization and preliminary X-ray analysis of the haloalkane dehalogenase DatA from Agrobacterium tumefaciens C58

    International Nuclear Information System (INIS)

    Mase, Tomoko; Yabuki, Hideya; Okai, Masahiko; Ohtsuka, Jun; Imai, Fabiana Lica; Nagata, Yuji; Tanokura, Masaru

    2012-01-01

    The haloalkane dehalogenase DatA from A. tumefaciens C58 was expressed, purified and crystallized by the sitting-drop vapour-diffusion method. X-ray diffraction data were collected to 1.70 Å resolution. Haloalkane dehalogenases are enzymes that catalyze the hydrolytic reaction of a wide variety of haloalkyl substrates to form the corresponding alcohol and hydrogen halide products. DatA from Agrobacterium tumefaciens C58 is a haloalkane dehalogenase that has a unique pair of halide-binding residues, asparagine (Asn43) and tyrosine (Tyr109), instead of the asparagine and tryptophan that are conserved in other members of the subfamily. DatA was expressed in Escherichia coli, purified and crystallized using the sitting-drop vapour-diffusion method with a reservoir solution consisting of 0.1 M CHES pH 8.6, 1.0 M potassium sodium tartrate, 0.2 M lithium sulfate, 0.01 M barium chloride. X-ray diffraction data were collected to 1.70 Å resolution. The space group of the crystal was determined as the primitive tetragonal space group P422, with unit-cell parameters a = b = 123.7, c = 88.1 Å. The crystal contained two molecules in the asymmetric unit

  7. A multi-decadal wind-wave hindcast for the North Sea 1949-2014: coastDat2

    Science.gov (United States)

    Groll, Nikolaus; Weisse, Ralf

    2017-12-01

    Long and consistent wave data are important for analysing wave climate variability and change. Moreover, such wave data are also needed in coastal and offshore design and for addressing safety-related issues at sea. Using the third-generation spectral wave model WAM a multi-decadal wind-wave hindcast for the North Sea covering the period 1949-2014 was produced. The hindcast is part of the coastDat database representing a consistent and homogeneous met-ocean data set. It is shown that despite not being perfect, data from the wave hindcast are generally suitable for wave climate analysis. In particular, comparisons of hindcast data with in situ and satellite observations show on average a reasonable agreement, while a tendency towards overestimation of the highest waves could be inferred. Despite these limitations, the wave hindcast still provides useful data for assessing wave climate variability and change as well as for risk analysis, in particular when conservative estimates are needed. Hindcast data are stored at the World Data Center for Climate (WDCC) and can be freely accessed using the doi:10.1594/WDCC/coastDat-2_WAM-North_Sea Groll and Weisse(2016) or via the coastDat web-page http://www.coastdat.de.

  8. Time-resolved influences of functional DAT1 and COMT variants on visual perception and post-processing.

    Directory of Open Access Journals (Sweden)

    Stephan Bender

    Full Text Available BACKGROUND: Dopamine plays an important role in orienting and the regulation of selective attention to relevant stimulus characteristics. Thus, we examined the influences of functional variants related to dopamine inactivation in the dopamine transporter (DAT1 and catechol-O-methyltransferase genes (COMT on the time-course of visual processing in a contingent negative variation (CNV task. METHODS: 64-channel EEG recordings were obtained from 195 healthy adolescents of a community-based sample during a continuous performance task (A-X version. Early and late CNV as well as preceding visual evoked potential components were assessed. RESULTS: Significant additive main effects of DAT1 and COMT on the occipito-temporal early CNV were observed. In addition, there was a trend towards an interaction between the two polymorphisms. Source analysis showed early CNV generators in the ventral visual stream and in frontal regions. There was a strong negative correlation between occipito-temporal visual post-processing and the frontal early CNV component. The early CNV time interval 500-1000 ms after the visual cue was specifically affected while the preceding visual perception stages were not influenced. CONCLUSIONS: Late visual potentials allow the genomic imaging of dopamine inactivation effects on visual post-processing. The same specific time-interval has been found to be affected by DAT1 and COMT during motor post-processing but not motor preparation. We propose the hypothesis that similar dopaminergic mechanisms modulate working memory encoding in both the visual and motor and perhaps other systems.

  9. Presence and function of dopamine transporter (DAT in stallion sperm: dopamine modulates sperm motility and acrosomal integrity.

    Directory of Open Access Journals (Sweden)

    Javier A Urra

    Full Text Available Dopamine is a catecholamine with multiple physiological functions, playing a key role in nervous system; however its participation in reproductive processes and sperm physiology is controversial. High dopamine concentrations have been reported in different portions of the feminine and masculine reproductive tract, although the role fulfilled by this catecholamine in reproductive physiology is as yet unknown. We have previously shown that dopamine type 2 receptor is functional in boar sperm, suggesting that dopamine acts as a physiological modulator of sperm viability, capacitation and motility. In the present study, using immunodetection methods, we revealed the presence of several proteins important for the dopamine uptake and signalling in mammalian sperm, specifically monoamine transporters as dopamine (DAT, serotonin (SERT and norepinephrine (NET transporters in equine sperm. We also demonstrated for the first time in equine sperm a functional dopamine transporter using 4-[4-(Dimethylaminostyryl]-N-methylpyridinium iodide (ASP(+, as substrate. In addition, we also showed that dopamine (1 mM treatment in vitro, does not affect sperm viability but decreases total and progressive sperm motility. This effect is reversed by blocking the dopamine transporter with the selective inhibitor vanoxerine (GBR12909 and non-selective inhibitors of dopamine reuptake such as nomifensine and bupropion. The effect of dopamine in sperm physiology was evaluated and we demonstrated that acrosome integrity and thyrosine phosphorylation in equine sperm is significantly reduced at high concentrations of this catecholamine. In summary, our results revealed the presence of monoamine transporter DAT, NET and SERT in equine sperm, and that the dopamine uptake by DAT can regulate sperm function, specifically acrosomal integrity and sperm motility.

  10. ClimaDat: A long-term network to study at different scales climatic processes and interactions between climatic compartments

    Science.gov (United States)

    Morgui, Josep Anton; Agueda, Alba; Batet, Oscar; Curcoll, Roger; Ealo, Marina; Grossi, Claudia; Occhipinti, Paola; Sánchez-García, Laura; Arias, Rosa; Rodó, Xavi

    2013-04-01

    ClimaDat (www.climadat.es) is a pioneer project of the Institut Català de Ciències del Clima (IC3) in collaboration with and funded by "la Caixa" Foundation. This project aims at studying the interactions between climate and ecosystems at different spatial and temporal scales. The ClimaDat project consists of a network of eight long-term observatory stations distributed over Spain, installed at natural and remote areas, and covering different climatic domains (e.g. Mediterranean, Atlantic, subtropics) and natural systems (e.g. delta, karsts, high mountain areas). Data obtained in the ClimaDat network will help us to understand how ecosystems are influenced by and eventually might feedback different processes in the climate system. The point of focus of these studies will be taken into account regional-and-local conditions to understand climatic global scale eventsThe data gathered will be used to study the behavior of the global element cycles and associated greenhouse gas emissions. The network is expected to offer near real-time (NRT) data free for the scientific community. Instrumentation installed at these stations mainly consists of: CO2, CH4, H2O, CO, N2O, SF6 and 222Rn analyzers, isotopic CO2, CH4 and H2O analyzers, meteorological sensors, eddy covariance equipment, four-component radiometers, soil moisture and temperature sensors, and sap flow meters. Each station may have a more focused subset of all this equipment, depending on the specific characteristics of the site. Instrumentation selected for this network has been chosen to comply with standards established in international research infrastructure projects, such as ICOS (http://www.icos-infrastructure.eu/home) or InGOS (http://www.ingos-infrastructure.eu/). Preliminary data time-series of greenhouse gases concentrations and meteorological variables are presented in this study for three currently operational ClimaDat stations: the Natural Park of the Ebre Delta (lat 40.75° N - long 0.79° E), the

  11. Analýza dat: výzvy a specifika v neurovědách a psychiatrii

    Czech Academy of Sciences Publication Activity Database

    Kalina, Jan; Zvárová, J.

    2017-01-01

    Roč. 156, č. 8 (2017), s. 430-436 ISSN 0008-7335 R&D Projects: GA MZd(CZ) NV15-33250A; GA ČR GA13-23940S Institutional support: RVO:67985807 Keywords : biostatistics * big data * psychiatry * decision support Subject RIV: BB - Applied Statistics, Operational Research OBOR OECD: Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8) http://www.prolekare.cz/casopis-lekaru-ceskych-clanek/analyza-dat-vyzvy-a-specifika-v-neurovedach-a-psychiatrii-62767

  12. [Study of genetic variants in the BDNF, COMT, DAT1 and SERT genes in Colombian children with attention deficit disorder].

    Science.gov (United States)

    Ortega-Rojas, Jenny; Arboleda-Bustos, Carlos E; Morales, Luis; Benítez, Bruno A; Beltrán, Diana; Izquierdo, Álvaro; Arboleda, Humberto; Vásquez, Rafael

    Attention deficit and hyperactive disorder (ADHD) is highly prevalent among children in Bogota City. Both genetic and environmental factors play a very important role in the etiology of ADHD. However, to date few studies have addressed the association of genetic variants and ADHD in the Colombian population. To test the genetic association between polymorphisms in the DAT1, HTTLPR, COMT and BDNF genes and ADHD in a sample from Bogota City. We genotyped the most common polymorphisms in DAT1, SERT, COMT and BDNF genes associated with ADHD using conventional PCR followed by restriction fragment length polymorphism (RFLP) in 97 trios recruited in a medical center in Bogota. The transmission disequilibrium test (TDT) was used to determine the association between such genetic variants and ADHD. The TDT analysis showed that no individual allele of any variant studied has a preferential transmission. Our results suggest that the etiology of the ADHD may be complex and involves several genetic factors. Further studies in other candidate polymorphisms in a larger sample size will improve our knowledge of the ADHD in Colombian population. Copyright © 2016 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

  13. Rozhraní typu I2C a jejich implementační možnosti v technologiích ASIC

    OpenAIRE

    Podzemný, Jakub

    2016-01-01

    Práce se zabývá možnostmi implementace I2C, SMBus a PMBus rozhraní v současných technologiích ASIC. V první části se práce zaměřuje na popis jednotlivých sběrnic a jejich vzájemných rozdílů dle nejnovějších specifikací z digitálního a funkčního pohledu. Analogová část problematiky je zde z velké části zanedbána. Dále se práce zabývá porovnáním vybraných I2C/SMBus slave modulů vytvořených firmou ON Semiconductor, popsaných v jazyce Verilog HDL, z hlediska počtu klopných obvodů, funkčnosti a př...

  14. DAT genotype modulates striatal processing and long-term memory for items associated with reward and punishment.

    Science.gov (United States)

    Wittmann, Bianca C; Tan, Geoffrey C; Lisman, John E; Dolan, Raymond J; Düzel, Emrah

    2013-09-01

    Previous studies have shown that appetitive motivation enhances episodic memory formation via a network including the substantia nigra/ventral tegmental area (SN/VTA), striatum and hippocampus. This functional magnetic resonance imaging (fMRI) study now contrasted the impact of aversive and appetitive motivation on episodic long-term memory. Cue pictures predicted monetary reward or punishment in alternating experimental blocks. One day later, episodic memory for the cue pictures was tested. We also investigated how the neural processing of appetitive and aversive motivation and episodic memory were modulated by dopaminergic mechanisms. To that end, participants were selected on the basis of their genotype for a variable number of tandem repeat polymorphism of the dopamine transporter (DAT) gene. The resulting groups were carefully matched for the 5-HTTLPR polymorphism of the serotonin transporter gene. Recognition memory for cues from both motivational categories was enhanced in participants homozygous for the 10-repeat allele of the DAT, the functional effects of which are not known yet, but not in heterozygous subjects. In comparison with heterozygous participants, 10-repeat homozygous participants also showed increased striatal activity for anticipation of motivational outcomes compared to neutral outcomes. In a subsequent memory analysis, encoding activity in striatum and hippocampus was found to be higher for later recognized items in 10-repeat homozygotes compared to 9/10-repeat heterozygotes. These findings suggest that processing of appetitive and aversive motivation in the human striatum involve the dopaminergic system and that dopamine plays a role in memory for both types of motivational information. In accordance with animal studies, these data support the idea that encoding of motivational events depends on dopaminergic processes in the hippocampus. © 2013 The Authors. Published by Elsevier Ltd. All rights reserved.

  15. DRD2 genotype-based variation of default mode network activity and of its relationship with striatal DAT binding.

    Science.gov (United States)

    Sambataro, Fabio; Fazio, Leonardo; Taurisano, Paolo; Gelao, Barbara; Porcelli, Annamaria; Mancini, Marina; Sinibaldi, Lorenzo; Ursini, Gianluca; Masellis, Rita; Caforio, Grazia; Di Giorgio, Annabella; Niccoli-Asabella, Artor; Popolizio, Teresa; Blasi, Giuseppe; Bertolino, Alessandro

    2013-01-01

    The default mode network (DMN) comprises a set of brain regions with "increased" activity during rest relative to cognitive processing. Activity in the DMN is associated with functional connections with the striatum and dopamine (DA) levels in this brain region. A functional single-nucleotide polymorphism within the dopamine D2 receptor gene (DRD2, rs1076560 G > T) shifts splicing of the 2 D2 isoforms, D2 short and D2 long, and has been associated with striatal DA signaling as well as with cognitive processing. However, the effects of this polymorphism on DMN have not been explored. The aim of this study was to evaluate the effects of rs1076560 on DMN and striatal connectivity and on their relationship with striatal DA signaling. Twenty-eight subjects genotyped for rs1076560 underwent functional magnetic resonance imaging during a working memory task and 123 55 I-Fluoropropyl-2-beta-carbomethoxy-3-beta(4-iodophenyl) nortropan Single Photon Emission Computed Tomography ([(123)I]-FP-CIT SPECT) imaging (a measure of dopamine transporter [DAT] binding). Spatial group-independent component (IC) analysis was used to identify DMN and striatal ICs. Within the anterior DMN IC, GG subjects had relatively greater connectivity in medial prefrontal cortex (MPFC), which was directly correlated with striatal DAT binding. Within the posterior DMN IC, GG subjects had reduced connectivity in posterior cingulate relative to T carriers. Additionally, rs1076560 genotype predicted connectivity differences within a striatal network, and these changes were correlated with connectivity in MPFC and posterior cingulate within the DMN. These results suggest that genetically determined D2 receptor signaling is associated with DMN connectivity and that these changes are correlated with striatal function and presynaptic DA signaling.

  16. The polymorphism of dopamine receptor D4 (DRD4) and dopamine transporter (DAT) genes in the men with antisocial behaviour and mixed martial arts fighters.

    Science.gov (United States)

    Cherepkova, Elena V; Maksimov, Vladimir N; Kushnarev, Alexandr P; Shakhmatov, Igor I; Aftanas, Lyubomir I

    2017-09-12

    Variable-number tandem repeat (VNTR) polymorphisms of DRD4 and DAT genes were studied in the Russian and Chechen men convicted of crimes, and two control groups comprised of the MMA fighters and a sample of general population. A group of MMA fighters included only the subjects without history of antisocial behaviour. DNA was isolated by phenol-chloroform extraction from the blood. Genotyping VNTR polymorphisms of the DRD4 and DAT genes were performed by PCR on published methods. Among those convicted of felonies and most grave crimes, carriers of DRD4 long alleles are found more frequently, similarly to the cohort of MMA fighters (lacking criminal record in both paternal lines). The 9/9 DAT genotype carriers are more frequently encountered among the habitual offenders. A frequency of the combination of the DRD4 genotype 4/7 and DAT genotype 10/10 is clearly higher among the convicts of violent crimes and the MMA fighters. One can speculate the presence of a 'controlled aggression' without a predisposition to pathological violence in the MMA fighters. Our study supports the hypothesis of genetic predisposition to different variants of extreme behaviour mediated by genetic determinants involved in the functioning of neuromediator systems including those controlling dopamine pathways.

  17. A genetic-demographic approach reveals a gender-specific association of SLC6A3/DAT1 40 bp-VNTR with life-expectancy.

    Science.gov (United States)

    Hadi, Fazal; Dato, Serena; Carpi, Francesco M; Prontera, Paolo; Crucianelli, Francesca; Renda, Federica; Passarino, Giuseppe; Napolioni, Valerio

    2015-06-01

    Several recent lines of evidence are proving an important role for dopamine in the aging process and in the determination of life span. Components of the dopaminergic system may represent good candidates for longevity studies. Herein, we tested the possible association of the functional SLC6A3/DAT1 40-bp VNTR with life-expectancy in a healthy population of Central Italy (N = 993) by applying a genetic-demographic approach that takes into account the demographic information and different survival rates between sexes for modeling the survival of specific allele carriers in the population. Male carriers of S*/S* genotype showed a lower survival chance across most of the lifespan respect to the survival of DAT1*L-carriers (P = 0.021). The same analyses gave non-significant results in females. Several studies already reported significant sex differences in dopamine metabolism and its related biological pathways. Thus, we can hypothesize that the SLC6A3/DAT1 40 bp-VNTR may affect life expectancy in a sex-specific way. Moreover, it is conceivable that DAT1 S*/S* carriers, who are prone to assume "risk" type behaviors, may be dropped out of the "healthy" population by a sort of "demographic selection".

  18. High sibling correlation on methylphenidate response but no association with DAT1-10R homozygosity in Dutch sibpairs with ADHD

    NARCIS (Netherlands)

    van der Meulen, Emma M; Bakker, Steven C; Pauls, David L; Oteman, Nicole; Kruitwagen, Cas L J J; Pearson, Peter L; Sinke, Richard J; Buitelaar, Jan K

    2005-01-01

    BACKGROUND: A minority of patients with attention-deficit hyperactivity disorder (ADHD) do not respond favorably to methylphenidate. This has been partially associated with homozygosity for the Dopamine transporter (DAT1) 10-repeat allele and the presence of one or two Dopamine D4 receptor (DRD4)

  19. High sibling correlation on methylphenidate response but no association with DAT1-10R homozygosity in Dutch sibpairs with ADHD.

    NARCIS (Netherlands)

    Meulen, E.M. van der; Bakker, S.C.; Pauls, D.L.; Oteman, N.; Kruitwagen, C.L.J.J.; Pearson, P.L.; Sinke, R.J.; Buitelaar, J.K.

    2005-01-01

    BACKGROUND: A minority of patients with attention-deficit hyperactivity disorder (ADHD) do not respond favorably to methylphenidate. This has been partially associated with homozygosity for the Dopamine transporter (DAT1) 10-repeat allele and the presence of one or two Dopamine D4 receptor (DRD4)

  20. Application of direct agglutination test (DAT) and fast agglutination screening test (FAST) for sero-diagnosis of visceral leishmaniasis in endemic area of Minas Gerais, Brazil

    NARCIS (Netherlands)

    Silva, Eduardo S.; Schoone, Gerard J.; Gontijo, Celia M. F.; Brazil, Reginaldo P.; Pacheco, Raquel S.; Schallig, Henk D. F. H.

    2005-01-01

    The direct agglutination test (DAT) has proved to be a very important sero-diagnostic tool combining high levels of intrinsic validity and ease of performance. Otherwise, fast agglutination screening test (FAST) utilises only one serum dilution making the test very suitable for the screening of

  1. NVGClient - Programový systém pro vizualizaci taktických dat ve 3D pro OTS VŘ PozS

    OpenAIRE

    Přenosil Václav; Františ Petr; Hodický Jan; Havelka Ladislav

    2012-01-01

    Program NVGClient je určený k přenosu taktických průsvitek z webové služby dle standardu NATO NVG do použitého vizualizačního programu. Při přenosu taktických průsvitek dochází k rozdělení jednotlivých grafických elementů (taktických značek) do určených kategorií a rovněž dochází k převodu symbolů (taktických značek) v přenášených průsvitkách dle kódu APP6B do jeho grafické podoby. Zároveň jsou taktické značky jednotek doplněny informacemi z příslušné databáze o jejich stavu (množství pohonný...

  2. Porovnání statistických programových systémů SPSS, STATISTICA a SAS z hlediska jejich možností při analýze kategoriálních dat

    OpenAIRE

    Torboněnko, Natalja

    2009-01-01

    The purpose of this bachelor thesis is to compare three statistical software packages when applied to analysis of categorical data. These packages are SPSS, STATISTICA , and SAS Enterprise Guide. They provide a wide variety of statistical and graphical techniques, and enable users to obtain the results of statistical procedures, without requiring programming. The comparison between these packages were based upon some features such as data input, capability to define missing values, value labe...

  3. Generation of the ECP database (ECP02.DAT) at the beginning of the cycle 1 of the Unit 1 of Laguna Verde

    International Nuclear Information System (INIS)

    Perusquia C, R.

    1992-10-01

    In order to carrying out a comparison among the results provided for the Program of Estimate of the ECP Critical Position and the Shutdown/Startup produced in the Cycle 1 of the Unit 1 of Laguna Verde, it was generated the base of the ECP program, following the outlines settled down in the Procedure 'Generation of ECP Database for Laguna Verde' (IT.SN/DFR 074). Next the data sheets filled when being generated the ECP02.DAT database at the beginning of the cycle are provided. In the IT.SN/DFR 079 report 'Adjustment and Preliminary Evaluation of the Predictions of Criticity of the ECP Program with Reported Data of Cycle 1 of the Unit 1 of Laguna Verde, the results of the comparison among the estimates of the ECP program using the ECP02.DAT with the real data of the Cycle 1 of the Unit 1 of Laguna Verde are presented. (Author)

  4. Generation of the ECP database (ECP01.DAT) of the cycle 1 of the Unit 1 of Laguna Verde with burnt of 1377 MWD/MT

    International Nuclear Information System (INIS)

    Perusquia C, R.

    1992-10-01

    In order to carrying out a comparison among the results provided by the Program of Estimate of the ECP Critical Position and the Shutdown/Startup produced in the Cycle 1 of the Unit 1 of Laguna Verde, it was generated the base of the ECP program, following the outlines settled down in the Procedure 'Generation of ECP Database for Laguna Verde' (IT.SN/DFR-074). Next the data sheets filled when being generated the ECP01.DAT database with a burnt of 1377 MWD/MT are provided. In the report IT.SN/DFR-079 'Adjustment and Preliminary Evaluation of the Predictions of Criticity of the ECP Program with Reported Data of the Cycle 1 of the Unit 1 of Laguna Verde', the results of the comparison among those estimates of the ECP program using the ECP01.DAT database with the real data of the Cycle 1 of the Unit 1 of Laguna Verde are presented. (Author)

  5. Further analysis and evaluation of the results of the NATO common shield-DAT#7 experiment: defence against terrorism

    Science.gov (United States)

    Dill, Stephan; Peichl, Markus; Jirousek, Matthias; Süß, Helmut

    2009-09-01

    The contactless control of persons and the remote surveillance of sensitive infrastructures are important tasks in order to provide the required security measures to protect the human population against the threads of international terrorism. Passive microwave imaging allows a daytime independent observation and examination of objects and persons under nearly all adverse ambient conditions without artificial exposure, hence fully avoiding health risks. The penetration capability of microwaves provides the detection of objects through atmospheric obstacles like bad weather, fog or dust, vapour and smoke, as well as through thin non-metallic materials and clothing. For the latter the detection of hidden objects like weapons, explosives, and contraband is possible by monitoring dielectric anomalies. The experiment "Common Shield" is part of a perennial investigation series leaded by the "Center for Transformation of the German armed forces (Bundeswehr)". In 2008 the protection of soldiers and facilities was experimentally investigated under the aspect of a networked operational leadership. In this context as well a harbour protection trial was carried out in August/September 2008 at the naval base Eckernfoerde in Germany. This trial was part of the NATO CNADs program of work for "Defence Against Terrorism (DAT)" starting in 2003, and Germany is the lead nation for item 7 on "Technology for Intelligence, Surveillance, Reconnaissance & Target Acquisition of Terrorists (ISRTA)". One main activity in the Eckernfoerde trial was the simulation of a military entrance control facility by a tent including various imaging and a chemical sensor suite in order to provide security for a military camp. Besides commercial optical and infrared cameras various passive millimeter-wave imagers have been used from different German research institutions. The DLR Microwaves and Radar Institute, Department for Reconnaissance and Security (HR-AS), provided an imaging radiometer scanner

  6. Dopamine and the Creative Mind: Individual Differences in Creativity Are Predicted by Interactions between Dopamine Genes DAT and COMT.

    Science.gov (United States)

    Zabelina, Darya L; Colzato, Lorenza; Beeman, Mark; Hommel, Bernhard

    2016-01-01

    The dopaminergic (DA) system may be involved in creativity, however results of past studies are mixed. We attempted to clarify this putative relation by considering the mediofrontal and the nigrostriatal DA pathways, uniquely and in combination, and their contribution to two different measures of creativity--an abbreviated version of the Torrance Test of Creative Thinking, assessing divergent thinking, and a real-world creative achievement index. We found that creativity can be predicted from interactions between genetic polymorphisms related to frontal (COMT) and striatal (DAT) DA pathways. Importantly, the Torrance test and the real-world creative achievement index related to different genetic patterns, suggesting that these two measures tap into different aspects of creativity, and depend on distinct, but interacting, DA sub-systems. Specifically, we report that successful performance on the Torrance test is linked with dopaminergic polymorphisms associated with good cognitive flexibility and medium top-down control, or with weak cognitive flexibility and strong top-down control. The latter is particularly true for the originality factor of divergent thinking. High real-world creative achievement, on the other hand, as assessed by the Creative Achievement Questionnaire, is linked with dopaminergic polymorphisms associated with weak cognitive flexibility and weak top-down control. Taken altogether, our findings support the idea that human creativity relies on dopamine, and on the interaction between frontal and striatal dopaminergic pathways in particular. This interaction may help clarify some apparent inconsistencies in the prior literature, especially if the genes and/or creativity measures were analyzed separately.

  7. The presence of both serotonin 1A receptor (HTR1A and dopamine transporter (DAT1 gene variants increase the risk of borderline personality disorder

    Directory of Open Access Journals (Sweden)

    Peter R Joyce

    2014-01-01

    Full Text Available Dysfunction in the dopaminergic and serotonergic neurotransmitter systems has been demonstrated to be important in the aetiology of Borderline personality disorder (BPD. We investigated the relationship of two BPD risk factors, the HTR1A promoter polymorphism -1019C>G (rs6295 and the DAT1 repeat allele, with BPD in a major depressive disorder cohort of 367 patients. Out-patients with major depressive disorder were recruited for two treatment trials and assessed for personality disorders, including BPD. DNA samples were collected and the rs6295 polymorphism was detected with a TaqMan® assay. The DAT1 repeat allele was genotyped using a modified PCR method. The impact of polymorphisms on BPD was statistically analysed using uncontrolled logistic and multiple logistic regression models. BPD patients had higher frequencies of the DAT1 9,9 (OR=2.67 and 9,10 (OR=3.67 genotypes and also those homozygous HTR1A G allele (OR=2.03. No significant interactions between HTR1A and DAT1 genotypes, were observed; however, an increased risk of BPD was observed for those patients who were either 9,10; G,G (OR=6.64 and 9,9; C,G (OR=5.42. Furthermore, the odds of BPD in patients exhibiting high-risk variants of these two genes differed from those of patients in low-risk groups by up to a factor of 9. Our study provides evidence implicating the importance of the serotonergic and dopaminergic systems in BPD and that the interaction between genes from different neurotransmitters may play a role in the susceptibility to BPD.

  8. Genetic Variation of the Dopamine Transporter (DAT1) Influences the Acute Subjective Responses to Cocaine in Volunteers with Cocaine Use Disorders

    Science.gov (United States)

    Brewer, Alex J.; Nielsen, David A.; Spellicy, Catherine J.; Hamon, Sara C.; Gingrich, Justin; Thompson-Lake, Daisy G. Y.; Nielsen, Ellen M.; Mahoney, James J.; Kosten, Thomas R.; Newton, Thomas F.; De La Garza, Richard

    2015-01-01

    Objective : The aim of this study was to identify gene variants of DAT1 (SLC6A3) that modulate subjective responses to acute cocaine exposure. Methods Non-treatment seeking volunteers with cocaine use disorders (CUDs) received a single bolus infusion of saline and cocaine (40 mg, IV) in randomized order. Subjective effects were assessed with visual analog scales administered before (-15 min) and up to 20 min after infusion. Subjective effects ratings were normalized to baseline and saline infusion values were subtracted. Data was analyzed using repeated measures ANOVA. DNA from subjects was genotyped for the DAT1 intron 8 (rs3836790) and 3’ UTR (rs28363170) variable number of tandem repeats. Results Participants were mostly male (~80%) and African American (~70%). No differences were found among drug use variables between groups for either polymorphism. Carriers of the 9-allele of the DAT1 3’ UTR (9,9 and 9,10) (n = 24) exhibited greater responses to cocaine for “high”, “any drug effect”, “anxious”, and “stimulated” (all p-values < 0.001) compared to individuals homozygous for the 10-allele (n = 33). For the intron 8 polymorphism, individuals homozygous for the 6 allele exhibited greater responses for “anxious” than carriers of the 5 allele (p < 0.001). Individuals possessing the genotype pattern of 10,10 and at least one 5-allele reported lower responses to “good effects”, “bad effects”, “depressed”, and “anxious” (all p-values < 0.01). Conclusions The data presented here support the hypothesis that genetic differences of DAT1 contribute to variation of subjective responses to cocaine among participants with CUDs. PMID:25850966

  9. DNA Methylation at the DAT Promoter and Risk for Psychopathology: Intergenerational Transmission between School-Age Youths and Their Parents in a Community Sample

    Directory of Open Access Journals (Sweden)

    Silvia Cimino

    2018-01-01

    Full Text Available BackgroundThe effect of gene polymorphisms and promoter methylation, associated with maladaptive developmental outcomes, vary depending on environmental factors (e.g., parental psychopathology. Most studies have focused on 0- to 5-year-old children, adolescents, or adults, whereas there is dearth of research on school-age youths and pre-adolescents.MethodsIn a sample of 21 families recruited at schools, we addressed parents’ psychopathological symptoms (through SCL-90-R; offspring emotional–behavioral functioning (through CBCL-6–18; dopamine transporter gene (DAT1 for epigenetic status of the 5′-untranslated region (UTR and for genotype, i.e., variable number of tandem repeats polymorphism at the 3′-UTR. Possible associations were explored between bio-genetic and psychological characteristics within the same individual and between triplets of children, mothers, and fathers.ResultsDAT methylation of CpG at positions M1, M6, and M7 in mothers was correlated with maternal (phobic anxiety, whereas in fathers’ position M6 was related to paternal depression, anxiety, hostility, psychoticism, and higher Global Severity Index (GSI. No significant correlations were found between maternal and offspring DAT methylation. Significant correlations were found between fathers’ methylation at CpG M1 and children’s methylation at CpG M6. Linear regressions showed that mothers and fathers’ GSI predicted children’s methylation at CpG sites M2, M3, and M6, whereas fathers’ GSI predicted children’s methylation at CpG sites, particularly M1, M2, and M6. Moreover, offspring methylation of DAT at CpG M2 predicted somatic complaint, internalizing and attention problems; methylation of DAT at CpG M6 predicted withdraw.ConclusionThis study may have important clinical implication for the prevention and treatment of emotional–behavioral difficulties in children, as it adds to previous knowledge about the role of genetic and environmental factors in

  10. Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors

    DEFF Research Database (Denmark)

    Cartier, Etienne; Hamilton, Peter J; Belovich, Andrea N

    2015-01-01

    BACKGROUND: Syntaxin 1 (STX1) is a presynaptic plasma membrane protein that coordinates synaptic vesicle fusion. STX1 also regulates the function of neurotransmitter transporters, including the dopamine (DA) transporter (DAT). The DAT is a membrane protein that controls DA homeostasis through...... the high-affinity re-uptake of synaptically released DA. METHODS: We adopt newly developed animal models and state-of-the-art biophysical techniques to determine the contribution of the identified gene variants to impairments in DA neurotransmission observed in autism spectrum disorder (ASD). OUTCOMES......: Here, we characterize two independent autism-associated variants in the genes that encode STX1 and the DAT. We demonstrate that each variant dramatically alters DAT function. We identify molecular mechanisms that converge to inhibit reverse transport of DA and DA-associated behaviors. These mechanisms...

  11. Rare Autism-Associated Variants Implicate Syntaxin 1 (STX1 R26Q) Phosphorylation and the Dopamine Transporter (hDAT R51W) in Dopamine Neurotransmission and Behaviors

    OpenAIRE

    Cartier, Etienne; Hamilton, Peter J.; Belovich, Andrea N.; Shekar, Aparna; Campbell, Nicholas G.; Saunders, Christine; Andreassen, Thorvald F.; Gether, Ulrik; Veenstra-Vanderweele, Jeremy; Sutcliffe, James S.; Ulery-Reynolds, Paula G.; Erreger, Kevin; Matthies, Heinrich J.G.; Galli, Aurelio

    2015-01-01

    Background: Syntaxin 1 (STX1) is a presynaptic plasma membrane protein that coordinates synaptic vesicle fusion. STX1 also regulates the function of neurotransmitter transporters, including the dopamine (DA) transporter (DAT). The DAT is a membrane protein that controls DA homeostasis through the high-affinity re-uptake of synaptically released DA. Methods: We adopt newly developed animal models and state-of-the-art biophysical techniques to determine the contribution of the identified gen...

  12. Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors.

    Science.gov (United States)

    Cartier, Etienne; Hamilton, Peter J; Belovich, Andrea N; Shekar, Aparna; Campbell, Nicholas G; Saunders, Christine; Andreassen, Thorvald F; Gether, Ulrik; Veenstra-Vanderweele, Jeremy; Sutcliffe, James S; Ulery-Reynolds, Paula G; Erreger, Kevin; Matthies, Heinrich J G; Galli, Aurelio

    2015-02-01

    Syntaxin 1 (STX1) is a presynaptic plasma membrane protein that coordinates synaptic vesicle fusion. STX1 also regulates the function of neurotransmitter transporters, including the dopamine (DA) transporter (DAT). The DAT is a membrane protein that controls DA homeostasis through the high-affinity re-uptake of synaptically released DA. We adopt newly developed animal models and state-of-the-art biophysical techniques to determine the contribution of the identified gene variants to impairments in DA neurotransmission observed in autism spectrum disorder (ASD). Here, we characterize two independent autism-associated variants in the genes that encode STX1 and the DAT. We demonstrate that each variant dramatically alters DAT function. We identify molecular mechanisms that converge to inhibit reverse transport of DA and DA-associated behaviors. These mechanisms involve decreased phosphorylation of STX1 at Ser14 mediated by casein kinase 2 as well as a reduction in STX1/DAT interaction. These findings point to STX1/DAT interactions and STX1 phosphorylation as key regulators of DA homeostasis. We determine the molecular identity and the impact of these variants with the intent of defining DA dysfunction and associated behaviors as possible complications of ASD.

  13. Heterogeneous transgene expression in the retinas of the TH-RFP, TH-Cre, TH-BAC-Cre and DAT-Cre mouse lines.

    Science.gov (United States)

    Vuong, H E; Pérez de Sevilla Müller, L; Hardi, C N; McMahon, D G; Brecha, N C

    2015-10-29

    Transgenic mouse lines are essential tools for understanding the connectivity, physiology and function of neuronal circuits, including those in the retina. This report compares transgene expression in the retina of a tyrosine hydroxylase (TH)-red fluorescent protein (RFP) mouse line with three catecholamine-related Cre recombinase mouse lines [TH-bacterial artificial chromosome (BAC)-, TH-, and dopamine transporter (DAT)-Cre] that were crossed with a ROSA26-tdTomato reporter line. Retinas were evaluated and immunostained with commonly used antibodies including those directed to TH, GABA and glycine to characterize the RFP or tdTomato fluorescent-labeled amacrine cells, and an antibody directed to RNA-binding protein with multiple splicing to identify ganglion cells. In TH-RFP retinas, types 1 and 2 dopamine (DA) amacrine cells were identified by their characteristic cellular morphology and type 1 DA cells by their expression of TH immunoreactivity. In the TH-BAC-, TH-, and DAT-tdTomato retinas, less than 1%, ∼ 6%, and 0%, respectively, of the fluorescent cells were the expected type 1 DA amacrine cells. Instead, in the TH-BAC-tdTomato retinas, fluorescently labeled AII amacrine cells were predominant, with some medium diameter ganglion cells. In TH-tdTomato retinas, fluorescence was in multiple neurochemical amacrine cell types, including four types of polyaxonal amacrine cells. In DAT-tdTomato retinas, fluorescence was in GABA immunoreactive amacrine cells, including two types of bistratified and two types of monostratified amacrine cells. Although each of the Cre lines was generated with the intent to specifically label DA cells, our findings show a cellular diversity in Cre expression in the adult retina and indicate the importance of careful characterization of transgene labeling patterns. These mouse lines with their distinctive cellular labeling patterns will be useful tools for future studies of retinal function and visual processing. Published by Elsevier

  14. Automatic semi-quantification of [123I]FP-CIT SPECT scans in healthy volunteers using BasGan version 2: results from the ENC-DAT database

    International Nuclear Information System (INIS)

    Nobili, Flavio; Naseri, Mehrdad; Morbelli, Silvia; De Carli, Fabrizio; Asenbaum, Susan; Booij, Jan; Darcourt, Jacques; Ell, Peter; Kapucu, Oezlem; Kemp, Paul; Varer, Claus; Pagani, Marco; Sabri, Osama; Tatsch, Klaus; Tossici-Bolt, Livia; Sera, Terez; Borght, Thierry vander; Laere, Koen van; Varrone, Andrea

    2013-01-01

    The aim of this study was to assess striatal dopamine transporter (DAT) availability in a large group of normal subjects. The study included 122 healthy subjects, aged 18-83 years, recruited in the multicentre 'ENC-DAT' study (promoted by the European Association of Nuclear Medicine). Brain single photon emission computed tomography (SPECT) was acquired by means of dual-head cameras 3 h after [ 123 I]FP-CIT administration. Specific to nondisplaceable binding ratios (SBRs) in the basal ganglia were computed using the 'BasGan' software, allowing automatic value extraction with partial volume effect correction. Multicentre camera inhomogeneity was taken into account by calibrating values on basal ganglia phantom data. SBR in each caudate nucleus (C) and putamen (P) were the dependent variables in a repeated measures general linear model analysis; age, gender, handedness and body mass index (BMI) were the independent variables. SBR values in C and P were significantly associated with age (mean rate decrease with age: 0.0306 per year, or 0.57 % of the general mean; p < 0.0001) and gender (women had higher values; p = 0.015), while no significant effect was found for handedness and BMI. A significant interaction was found between age and region (p < 0.0001) as the age-related decline was 0.028 for left C, 0.026 for right C and 0.034 for both P. P/C ratio analysis confirmed that age-related SBR decrease was stronger in P than in C (p < 0.0001). No significant effect was found for season or time of the day when the scan was acquired by analysing the residual of SBR values in C and P, after subtraction of age and gender effects. This study confirms the dependency of DAT on ageing and highlights the gender differences in a large sample of healthy subjects, while it does not support the dependency of DAT on BMI, handedness, circadian rhythm or season. (orig.)

  15. Generation of the ECP database (ECP02.DAT) at the beginning of the cycle 1 of the Unit 1 of Laguna Verde; Generacion de la base ECP (ECP02.DAT) al inicio del ciclo 1 de la Unidad 1 de Laguna Verde

    Energy Technology Data Exchange (ETDEWEB)

    Perusquia C, R. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    1992-10-15

    In order to carrying out a comparison among the results provided for the Program of Estimate of the ECP Critical Position and the Shutdown/Startup produced in the Cycle 1 of the Unit 1 of Laguna Verde, it was generated the base of the ECP program, following the outlines settled down in the Procedure 'Generation of ECP Database for Laguna Verde' (IT.SN/DFR 074). Next the data sheets filled when being generated the ECP02.DAT database at the beginning of the cycle are provided. In the IT.SN/DFR 079 report 'Adjustment and Preliminary Evaluation of the Predictions of Criticity of the ECP Program with Reported Data of Cycle 1 of the Unit 1 of Laguna Verde, the results of the comparison among the estimates of the ECP program using the ECP02.DAT with the real data of the Cycle 1 of the Unit 1 of Laguna Verde are presented. (Author)

  16. Saikosaponin A Alleviates Symptoms of Attention Deficit Hyperactivity Disorder through Downregulation of DAT and Enhancing BDNF Expression in Spontaneous Hypertensive Rats

    Directory of Open Access Journals (Sweden)

    Sun Jichao

    2017-01-01

    Full Text Available The disturbed dopamine availability and brain-derived neurotrophic factor (BDNF expression are due in part to be associated with attention deficit hyperactivity disorder (ADHD. In this study, we investigated the therapeutical effect of saikosaponin a (SSa isolated from Bupleurum Chinese DC, against spontaneously hypertensive rat (SHR model of ADHD. Methylphenidate and SSa were orally administered for 3 weeks. Activity was assessed by open-field test and Morris water maze test. Dopamine (DA and BDNF were determined in specific brain regions. The mRNA or protein expression of tyrosine hydroxylase (TH, dopamine transporter (DAT, and vesicles monoamine transporter (VMAT was also studied. Both MPH and SSa reduced hyperactivity and improved the spatial learning memory deficit in SHRs. An increased DA concentration in the prefrontal cortex (PFC and striatum was also observed after treating with the SSa. The increased DA concentration may partially be attributed to the decreased mRNA and protein expression of DAT in PFC while SSa exhibited no significant effects on the mRNA expression of TH and VMAT in PFC of SHRs. In addition, BDNF expression in SHRs was also increased after treating with SSa or MPH. The obtained result suggested that SSa may be a potential drug for treating ADHD.

  17. Rozšíření funkcionality systému pro dolování z dat na platformě NetBeans

    OpenAIRE

    Šebek, Michal

    2009-01-01

    Databáze se neustále rozrůstají o nová data. Za účelem analýzy těchto dat byl definován proces získávání znalostí z databází. Pro podporu tohoto procesu vznikla řada nástrojů. Vývojem jednoho z těchto nástrojů se zabývá tato práce. Hlavním cílem je analyzovat stávající implementaci systému na přenositelné platformě Java NetBeans a databázovém serveru Oracle a rozšířit ji o algoritmy z oblasti předzpracování a analýzy vstupních dat. Podrobně je popsána implementace jednotlivých komponent pro p...

  18. Smoking-specific parenting and smoking onset in adolescence: the role of genes from the dopaminergic system (DRD2, DRD4, DAT1 genotypes.

    Directory of Open Access Journals (Sweden)

    Marieke Hiemstra

    Full Text Available Although only few studies have shown direct links between dopaminergic system genes and smoking onset, this does not rule out the effect of a gene-environment interaction on smoking onset. Therefore, the aim of this study was to examine the associations between smoking-specific parenting (i.e., frequency and quality of communication and house rules and smoking onset while considering the potential moderating role of dopaminergic system genes (i.e., DRD2, DRD4, and DAT1 genotypes. Data from five annual waves of the 'Family and Health' project were used. At time 1, the sample comprised 365 non-smoking adolescents (200 younger adolescents, mean age = 13.31, SD = .48; 165 older adolescents, mean age = 15.19, SD = .57. Advanced longitudinal analyses were used (i.e., logistic regression analyses, (dual latent growth curves, and cross-lagged path models. The results showed a direct effect of quality of communication on smoking onset. No direct effects were found for frequency of communication and house rules. Furthermore, no direct and moderating effects of the DRD2, DRD4, or DAT1 genotypes were found. In conclusion, the findings indicated that the effects of smoking-specific parenting on smoking are similar for adolescent carriers and non-carriers of the dopaminergic system genes.

  19. [11C]PR04.MZ, a promising DAT ligand for low concentration imaging: synthesis, efficient 11C-O-methylation and initial small animal PET studies

    International Nuclear Information System (INIS)

    Riss, P.J.; Hooker, J.; Alexoff, D.; Kim, Sung-Won; Fowler, J.S.; Roesch, F.

    2009-01-01

    PR04.MZ was designed as a highly selective dopamine transporter inhibitor, derived from natural cocaine. Its binding profile indicates that [ 11 C]PR04.MZ may be suited as a PET radioligand for the non-invasive exploration of striatal and extrastriatal DAT populations. As a key feature, its structural design facilitates both, labelling with fluorine-18 at its terminally fluorinated butynyl moiety and carbon-11 at its methyl ester function. The present report concerns the efficient [ 11 C]MeI mediated synthesis of [ 11 C]PR04.MZ from an O-desmethyl precursor trifluoroacetic acid salt with Rb 2 CO 3 in DMF in up to 95 ± 5% labelling yield. A preliminary μPET-experiment demonstrates the reversible, highly specific binding of [ 11 C]PR04.MZ in the brain of a male Sprague-Dawley rat.

  20. Procesy obnovy a jejich aplikace

    OpenAIRE

    Rychterová, Nela

    2016-01-01

    In this work we study the renewal theory. At first, we define the basic terms, express and prove the basic theorems. Remarks are added for better understan- ding. Secondly, we express the renewal theorem and its equivalent versions. Fi- nally, we provide examples of application of the theory. 1

  1. AYAT-AYAT WAH}DAT AL-WUJUd dalam Kitab Tanbi>h al-Ma>shi Karya ‘Abdurrauf al-Sinkili

    Directory of Open Access Journals (Sweden)

    Asep Nahrul Musadad

    2015-08-01

    Full Text Available Abstract: One of the key moments in discussing the history of Indonesian Islam is a polemic related to the negotiation on the doctrine of wahdat al-wujud that occured in Aceh in 17th century between the followers of Hamzah al-Fansuri and Nuruddin al-Raniri. This article focuses on analyzing several Qur’anic verses used by ‘Abdurrauf as the confirmation of his argument. In the polemical context, Abdurrauf al-Sinkili appeared to be an actor of reconciliation between two opposite sides. He tried to respond to the disputed issues through his book called “Tanbi>h al-Mashi”. As an exponent of the so-called moderate sufism (mysticism, he built the argument concerning wah}dat al-wujud based on the Quranic text. After making a thematic classification chronologically, his interpretation on these verses is analyzed by using Hussain al-Dhahaby’s theory of sufistic exegesis. In conclusion, it shows that ‘Abdurrauf’s commentary is “sufi-nazari type”, featured by his exegeses pattern. This, of course, represents his attitude as a reconciler who then needs to seek confirmation to the Qur’anic verses in evaluating wah}dat al-wujud doctrine, through which such a polemical issues occurred at that time. الملخص: إن من المرحلة الأساسية التي مرّ بها تاريخ الإسلام في اندونيسيا الجدل و النزاع حول عقيدة وحدة الوجود فى أتشيه (Aceh حول قرن السابع عشر بين أتباع حمزة الفنسوري و نور الدين الرانيري. ففي ذلك الخطاب النزاعي جاء عبد الرؤوف السنكيلي مصلحا بين الجانبين المعاكسين. وعلى مقتضى الظروف، كتب كتاب " تنبيه الماشي" الذي تطرّق فيه طريق التوسّط، ممثّلا للتصوّف المعتدل. اعتمد عبد الرؤوف على النصوص القرآنية فى تحقيق آراءه حول ت

  2. Generation of the ECP database (ECP01.DAT) of the cycle 1 of the Unit 1 of Laguna Verde with burnt of 1377 MWD/MT; Generacion de la base ECP (ECP01.DAT) del ciclo 1 de la Unidad 1 de Laguna Verde con quemado de 1377 MWD/MT

    Energy Technology Data Exchange (ETDEWEB)

    Perusquia C, R. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    1992-10-15

    In order to carrying out a comparison among the results provided by the Program of Estimate of the ECP Critical Position and the Shutdown/Startup produced in the Cycle 1 of the Unit 1 of Laguna Verde, it was generated the base of the ECP program, following the outlines settled down in the Procedure 'Generation of ECP Database for Laguna Verde' (IT.SN/DFR-074). Next the data sheets filled when being generated the ECP01.DAT database with a burnt of 1377 MWD/MT are provided. In the report IT.SN/DFR-079 'Adjustment and Preliminary Evaluation of the Predictions of Criticity of the ECP Program with Reported Data of the Cycle 1 of the Unit 1 of Laguna Verde', the results of the comparison among those estimates of the ECP program using the ECP01.DAT database with the real data of the Cycle 1 of the Unit 1 of Laguna Verde are presented. (Author)

  3. Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders

    DEFF Research Database (Denmark)

    Zou, Mu Fa; Cao, Jianjing; Abramyan, Ara M.

    2017-01-01

    microsomes and compared to cocaine in locomotor activity and drug discrimination paradigms in mice. A molecular dynamic simulation study supported the hypothesis that atypical DAT inhibitors have similar binding poses at DAT in a conformation that differs from that of cocaine. Such differences may ultimately...

  4. European multicentre database of healthy controls for [123I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis

    International Nuclear Information System (INIS)

    Varrone, Andrea; Dickson, John C.; Tossici-Bolt, Livia; Sera, Terez; Asenbaum, Susanne; Booij, Jan; Kapucu, Ozlem L.; Kluge, Andreas; Knudsen, Gitte M.; Koulibaly, Pierre Malick; Nobili, Flavio; Pagani, Marco; Sabri, Osama; Borght, Thierry vander; Laere, Koen van; Tatsch, Klaus

    2013-01-01

    Dopamine transporter (DAT) imaging with [ 123 I]FP-CIT (DaTSCAN) is an established diagnostic tool in parkinsonism and dementia. Although qualitative assessment criteria are available, DAT quantification is important for research and for completion of a diagnostic evaluation. One critical aspect of quantification is the availability of normative data, considering possible age and gender effects on DAT availability. The aim of the European Normal Control Database of DaTSCAN (ENC-DAT) study was to generate a large database of [ 123 I]FP-CIT SPECT scans in healthy controls. SPECT data from 139 healthy controls (74 men, 65 women; age range 20 - 83 years, mean 53 years) acquired in 13 different centres were included. Images were reconstructed using the ordered-subset expectation-maximization algorithm without correction (NOACSC), with attenuation correction (AC), and with both attenuation and scatter correction using the triple-energy window method (ACSC). Region-of-interest analysis was performed using the BRASS software (caudate and putamen), and the Southampton method (striatum). The outcome measure was the specific binding ratio (SBR). A significant effect of age on SBR was found for all data. Gender had a significant effect on SBR in the caudate and putamen for the NOACSC and AC data, and only in the left caudate for the ACSC data (BRASS method). Significant effects of age and gender on striatal SBR were observed for all data analysed with the Southampton method. Overall, there was a significant age-related decline in SBR of between 4 % and 6.7 % per decade. This study provides a large database of [ 123 I]FP-CIT SPECT scans in healthy controls across a wide age range and with balanced gender representation. Higher DAT availability was found in women than in men. An average age-related decline in DAT availability of 5.5 % per decade was found for both genders, in agreement with previous reports. The data collected in this study may serve as a reference database for

  5. European multicentre database of healthy controls for [{sup 123}I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis

    Energy Technology Data Exchange (ETDEWEB)

    Varrone, Andrea [Karolinska University Hospital, R5:02, Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm (Sweden); Dickson, John C. [UCLH NHS Foundation Trust and University College, Institute of Nuclear Medicine, London (United Kingdom); Tossici-Bolt, Livia [University Hospitals Southampton NHS Trust, Department of Medical Physics, Southampton (United Kingdom); Sera, Terez [University of Szeged, Department of Nuclear Medicine and Euromedic Szeged, Szeged (Hungary); Asenbaum, Susanne [Medical University of Vienna, Department of Nuclear Medicine, Vienna (Austria); Booij, Jan [University of Amsterdam, Department of Nuclear Medicine, Academic Medical Centre, Amsterdam (Netherlands); Kapucu, Ozlem L. [Gazi University, Department of Nuclear Medicine, Faculty of Medicine, Ankara (Turkey); Kluge, Andreas [ABX-CRO, Dresden (Germany); Knudsen, Gitte M. [Rigshospitalet and University of Copenhagen, Neurobiology Research Unit, Copenhagen (Denmark); Koulibaly, Pierre Malick [University of Nice-Sophia Antipolis, Nuclear Medicine Department, Centre Antoine Lacassagne, Nice (France); Nobili, Flavio [University of Genoa, Clinical Neurophysiology Unit, Department of Neuroscience, Ophthalmology and Genetics, Genoa (Italy); Pagani, Marco [Institute of Cognitive Sciences and Technologies, CNR, Rome (Italy); Karolinska University Hospital, Department of Nuclear Medicine, Stockholm (Sweden); Sabri, Osama [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Borght, Thierry vander [Universite Catholique de Louvain, Nuclear Medicine Division, Mont-Godinne Medical Center, Yvoir (Belgium); Laere, Koen van [University Hospital and K.U. Leuven, Nuclear Medicine, Leuven (Belgium); Tatsch, Klaus [Municipal Hospital of Karlsruhe Inc, Department of Nuclear Medicine, Karlsruhe (Germany)

    2013-02-15

    Dopamine transporter (DAT) imaging with [{sup 123}I]FP-CIT (DaTSCAN) is an established diagnostic tool in parkinsonism and dementia. Although qualitative assessment criteria are available, DAT quantification is important for research and for completion of a diagnostic evaluation. One critical aspect of quantification is the availability of normative data, considering possible age and gender effects on DAT availability. The aim of the European Normal Control Database of DaTSCAN (ENC-DAT) study was to generate a large database of [{sup 123}I]FP-CIT SPECT scans in healthy controls. SPECT data from 139 healthy controls (74 men, 65 women; age range 20 - 83 years, mean 53 years) acquired in 13 different centres were included. Images were reconstructed using the ordered-subset expectation-maximization algorithm without correction (NOACSC), with attenuation correction (AC), and with both attenuation and scatter correction using the triple-energy window method (ACSC). Region-of-interest analysis was performed using the BRASS software (caudate and putamen), and the Southampton method (striatum). The outcome measure was the specific binding ratio (SBR). A significant effect of age on SBR was found for all data. Gender had a significant effect on SBR in the caudate and putamen for the NOACSC and AC data, and only in the left caudate for the ACSC data (BRASS method). Significant effects of age and gender on striatal SBR were observed for all data analysed with the Southampton method. Overall, there was a significant age-related decline in SBR of between 4 % and 6.7 % per decade. This study provides a large database of [{sup 123}I]FP-CIT SPECT scans in healthy controls across a wide age range and with balanced gender representation. Higher DAT availability was found in women than in men. An average age-related decline in DAT availability of 5.5 % per decade was found for both genders, in agreement with previous reports. The data collected in this study may serve as a reference

  6. Charakteristické rysy gotického románu a jejich vliv na tragický vývoj ženských hrdinek v díle Emily Brontëové Na Větrné Hůrce a Henryho Jamese Utažení šroubu

    OpenAIRE

    POSPÍCHALOVÁ, Kateřina

    2012-01-01

    The thesis ?Charakteristické rysy gotického románu a jejich vliv na tragický vývoj ženských hrdinek v díle Emily Brontëové Na Větrné hůrce a Henryho Jamese Utažení šroubu? is focused on heroines of these books and their fates and it analyzes elements of these books. The aim of the thesis is to specifficaly find and to analyze characteristic elements of gothic fiction in the books. The thesis is also focused on tragic development of the heroines, probable causes of their tragic fates and the c...

  7. Methylphenidate DAT binding in adolescents with Attention-Deficit/ Hyperactivity Disorder comorbid with Substance Use Disorder--a single photon emission computed tomography with [Tc(99m)]TRODAT-1 study.

    Science.gov (United States)

    Szobot, Claudia M; Shih, Ming Chi; Schaefer, Thais; Júnior, Neivo; Hoexter, Marcelo Q; Fu, Ying Kai; Pechansky, Flávio; Bressan, Rodrigo A; Rohde, Luis A P

    2008-04-15

    Attention-Deficit/Hyperactivity Disorder (ADHD) is highly prevalent among adolescents with Substance Use Disorders (SUD). Effects of methylphenidate (MPH) on ADHD are attributed to its properties of blocking the dopamine transporter (DAT) in the striatum. However, it has been demonstrated that drug addiction is associated with dopaminergic system changes that may affect MPH brain effects, emphasizing the need to better understand MPH actions in subjects with ADHD+SUD. To evaluate the effect of an extended release formulation of MPH (MPH-SODAS) on DAT availability in 17 stimulant-naive ADHD adolescents with comorbid SUD (cannabis and cocaine). Subjects underwent two single photon emission computed tomography (SPECT) scans with [Tc(99m)]TRODAT-1, at baseline and after 3 weeks on MPH-SODAS. Clinical assessment for ADHD relied on the Swanson, Nolan and Pelham Scale - version IV (SNAP-IV). Caudate and putamen DAT binding potential (BP) was calculated. After 3 weeks on MPH-SODAS, there was a significant reduction of SNAP-IV total scores (pADHD patients without SUD comorbidity, providing neurobiological support for trials with stimulants in adolescents with ADHD+SUD, an important population excluded from studies.

  8. A single one-step radiosynthesis of [{sup 18}F]L.B.T.-999, a novel and selective dat radioligand for PET

    Energy Technology Data Exchange (ETDEWEB)

    Dolle, F.; Hinnen, F.; Saba, W.; Schollhorn-peyronneau, M.A.; Valette, H.; Bottlaender, M. [Service Hospitalier Frederic Joliot, DSV/ Institut d' Imagerie BioMedicale, 91 - Orsay (France); Helfenbein, J.; Le gailliard, J. [Institut National de la Sante et de la Recherche Medicale (INSERM), U484, Orphachem, ZATE, 63 - Clermont Ferrand (France); Mavel, S.; Mincheva, Z.; Garreau, L.; Chalon, S.; Guilloteau, D.; Emond, P. [Institut National de la Sante et de la Recherche Medicale (INSERM), U619, 37 - Tours (France); Mavel, S.; Garreau, L.; Chalon, S.; Guilloteau, D.; Emond, P. [Universite Francois Rabelais de Tours, 37 (France); Halldin, C. [Karolinska Institut, Dept. of Clinical Neuroscience, Karolinska Hospital, Stockholm (Sweden); Madelmont, J.C. [Institut National de la Sante et de la Recherche Medicale (INSERM) U484, Lab. Etude Metabolique des Molecules Marquees, 63 - Clermont Ferrand (France); Deloye, J.B. [Biopole Clermont Limagne, Lab. Cyclopharma, 63 - Saint Beauzire (France); Guilloteau, D. [Centre Hospitalier Regional Universitaire, 37 - Tours (France)

    2008-02-15

    L.B.T.-999 (8-((E)-4-fluoro-but-2-enyl)-3-beta-p-tolyl-8- aza-bi-cyclo[3.2.1]octane-2-beta-carboxylic acid methyl ester) is a recently developed cocaine derivative belonging to a new generation of highly selective D.A.T. ligands [1-3]. Initial fluorine-18-labelling of L.B.T.-999 was based on the robust and reliable two-step radiochemical pathway often reported for such tropane derivatives, involving first the preparation of (E)-1-[{sup 18}F]fluoro-4-tosyloxybut-2-ene followed by a N-alkylation reaction with the appropriate nor-tropane moiety [4]. In the present work, a simple one-step fluorine-18-labelling of L.B.T.-999 is reported, based on a chlorine-for-fluorine nucleophilic aliphatic substitution, facilitating as expected both automation and final H.P.L.C. purification. The process involves: (A) reaction of K[{sup 18}F]F-Kryptofix 222 with the chlorinated precursor (3.5-4.5 mg) at 165 degrees C for 10 min in D.M.S.O. (0.6 m L) followed by (B) C-18 PrepSep cartridge pre-purification and finally (C) semi preparative HPLC purification on a Waters Symmetry C-18. Typically, 3.70-5.92 GBq of [{sup 18}F]L.B.T.-999 (> 95% chemically and radiochemically pure) could be obtained with specific radioactivities ranging from 37 to 111 GBq/micro-mol within 85-90 min (HPLC purification and Sep-Pak-based formulation included), starting from a 37.0 GBq [{sup 18}F]fluoride batch (overall radiochemical yields: 10-16%, non decay corrected) [5].Supported in part by the E.C. - F.P.6-project D.i.M.I. (L.S.H.B.-C.T.- 2005-512146) and the R.N.T.S. 03 B 243 Fluoropak program. (authors)

  9. Parcels and Land Ownership, Derived from countywide parcel cover (scparcel) and CAMA.dat info table. Primary attributes include Parcel IDS (Control, Key, and PIN), calculated acreage, Appraiser's most recent landcover assessment year, and Appraiser's property ownership and value., Published in 2008, 1:1200 (1in=100ft) scale, Sedgwick County Government.

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Parcels and Land Ownership dataset current as of 2008. Derived from countywide parcel cover (scparcel) and CAMA.dat info table. Primary attributes include Parcel IDS...

  10. Título da página electrónica: EM-DAT, The International Disaster Database – Centre for Research on the Epidemiology of Disaster (CRED

    Directory of Open Access Journals (Sweden)

    Susana Freiria

    2012-12-01

    Full Text Available A EM-DAT consiste numa base de dados com mais de 18 000 grandes desastres ocorridos em todo o mundo desde 1900. Um dado fenómeno é considerado um desastre quando se verifica pelo menos uma das seguintes situações: 10 ou mais pessoas são dadas como vítimas mortais; 100 ou mais pessoas são registadas como afectadas; é emitida uma declaração de estado de emergência; é feito um pedido de ajuda internacional. A base é mantida pelo Centro de Pesquisa em Epidemiologia de Desastres, na Escola de Saú...

  11. Automatic semi-quantification of [{sup 123}I]FP-CIT SPECT scans in healthy volunteers using BasGan version 2: results from the ENC-DAT database

    Energy Technology Data Exchange (ETDEWEB)

    Nobili, Flavio [University of Genoa, Clinical Neurophysiology, Department of Neurosciences, Ophthalmology and Genetics, Genoa (Italy); Naseri, Mehrdad; Morbelli, Silvia [University of Genoa, Nuclear Medicine Unit, Department of Internal Medicine, Genoa (Italy); De Carli, Fabrizio [National Research Council, Institute of Bioimaging and Molecular Physiology, Genoa (Italy); Asenbaum, Susan [Medical University of Vienna, Department of Neurology, Vienna (Austria); Booij, Jan [University of Amsterdam, Department of Nuclear Medicine, Academic Medical Center, Amsterdam (Netherlands); Darcourt, Jacques [University of Nice Sophia Antipolis, Nuclear Medicine Department Centre Antoine Lacassagne TIRO Laboratory CEA, Nice (France); Ell, Peter [University College London Hospitals NHS Trust, Institute of Nuclear Medicine, London (United Kingdom); Kapucu, Oezlem [Gazi University School of Medicine, Department of Nuclear Medicine, Gazi Hospital, Besevler, Ankara (Turkey); Kemp, Paul [Southampton University Hospitals Trust, Department of Nuclear Medicine, Southampton (United Kingdom); Varer, Claus [Copenhagen University Hospital, Rigshospitalet, Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging (CIMBI), Copenhagen (Denmark); Pagani, Marco [Karolinska University Hospital, Department of Nuclear Medicine, Stockholm (Sweden); Consiglio Nazionale delle Ricerche (CNR), Institute of Cognitive Sciences and Technologies, Rome (Italy); Sabri, Osama [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Tatsch, Klaus [Municipal Hospital of Karlsruhe Inc., Department of Nuclear Medicine, Karlsruhe (Germany); Tossici-Bolt, Livia [Southampton University Hospitals NHS Trust, Department of Medical Physics and Bioengineering, Southampton (United Kingdom); Sera, Terez [University of Szeged, Department of Nuclear Medicine and Euromedic Szeged, Szeged (Hungary); Borght, Thierry vander [Universite Catholique de Louvain, Nuclear Medicine Division, Mont-Godinne Medical Center, Yvoir (Belgium); Laere, Koen van [University Hospitals Leuven, Division of Nuclear Medicine, Leuven (Belgium); Varrone, Andrea [Karolinska Hospital, Centre for Psychiatry Research, Karolinska Institutet, Stockholm (Sweden)

    2013-04-15

    The aim of this study was to assess striatal dopamine transporter (DAT) availability in a large group of normal subjects. The study included 122 healthy subjects, aged 18-83 years, recruited in the multicentre 'ENC-DAT' study (promoted by the European Association of Nuclear Medicine). Brain single photon emission computed tomography (SPECT) was acquired by means of dual-head cameras 3 h after [{sup 123}I]FP-CIT administration. Specific to nondisplaceable binding ratios (SBRs) in the basal ganglia were computed using the 'BasGan' software, allowing automatic value extraction with partial volume effect correction. Multicentre camera inhomogeneity was taken into account by calibrating values on basal ganglia phantom data. SBR in each caudate nucleus (C) and putamen (P) were the dependent variables in a repeated measures general linear model analysis; age, gender, handedness and body mass index (BMI) were the independent variables. SBR values in C and P were significantly associated with age (mean rate decrease with age: 0.0306 per year, or 0.57 % of the general mean; p < 0.0001) and gender (women had higher values; p = 0.015), while no significant effect was found for handedness and BMI. A significant interaction was found between age and region (p < 0.0001) as the age-related decline was 0.028 for left C, 0.026 for right C and 0.034 for both P. P/C ratio analysis confirmed that age-related SBR decrease was stronger in P than in C (p < 0.0001). No significant effect was found for season or time of the day when the scan was acquired by analysing the residual of SBR values in C and P, after subtraction of age and gender effects. This study confirms the dependency of DAT on ageing and highlights the gender differences in a large sample of healthy subjects, while it does not support the dependency of DAT on BMI, handedness, circadian rhythm or season. (orig.)

  12. On-line distance assisted training program for nuclear medicine technologists applied to SPECT-CT and PET-CT (Program DAT-OL). Results of a first course in Argentina

    International Nuclear Information System (INIS)

    Furnari, J C; Notari, C; Daoud, A; Giannone, C A

    2012-01-01

    The CNEA and the IDB are running for the second time the Distance Assisted Training course (DAT-OL), which is part of a global program of the International Atomic Energy Agency (IAEA) for Nuclear Medicine technologists working in centers equipped with PET CT and / or SPECT-CT hybrids. Aims: Completion of this course is justified by the strong increase in the installation of hybrid nuclear medicine (NM) systems, the increasing demand for qualified technicians and the lack of formal training opportunity. The course objective is to both promote the qualification of the technologist as improving quality and operational safety in MN participating centers. Material and Methods: This new course is free and is taught in Spanish from the www.datnmt.org website. The study material is available on site and the training is aided by tutors of institutions as CNEA, FUESMEN (School of Nuclear Medicine Foundation), UBA (University of Buenos Aires) and Nuclear Medicine private labs. The DAT-OL is developed in modules: Physics of SPECT / CT and PET / CT; Principles and sectional anatomy CT, SPECT / CT and PET / CT clinical; cyclotron and radiopharmaceutical production; Radiation Safety in PET / CT; Workflows and protocols with PET / CT, clinical reports: normal variants, artifacts and failures. Some of the requirements to take the DAT-OL are: Access to camera PET / CT and / or camera SPECT / CT, and a supervisor (Nuclear Medicine physician or Medical physicist) at the center of NM where the student works. Technicians must have academic qualification, 5 or more years working in centers MN, previous courses in Biology, Physics SPECT and SPECT Clinical course and a Methodology of Radioisotopes and radiation protection course. Results: The first course lasted 12 months including examinations. Tutors have scarcely been consulted. SPECT/CT and PET/CT web examinations, have been developed and evaluated by the authors of the course (B. Hutton and H. Patterson, University of London and

  13. Datça-Bozburun Yarımadası (Ege Denizi Kıyı Balıkçılığı ve Sorunları Üzerine Bir Araştırma.

    Directory of Open Access Journals (Sweden)

    Okan Akyol

    2015-12-01

    Full Text Available Bu çalışmada, Datça-Bozburun Yarımadası’nın kıyı balıkçılık aktiviteleri, hedef balık türleri, balıkçılık sorunları, balıkçı kooperatiflerinin özellikleri, balıkçı tekneleri ve barınakları araştırılmıştır. Örneklemeler iki balıkçı kooperatifi (Datça ve Karaköy ve 8 balıkçılık barınağında 2005-2006 yılları arasında yürütülmüştür. Bölgede toplam 32 kooperatif üyesi ile yaklaşık 170 balıkçı teknesi kaydedilmiştir. Üye sayılarına göre en büyük balıkçı kooperatifi Datça’dır. Bölgede kıyı balıkçılığı yoğun olarak paragat, sade ve fanyalı uzatma ağlarıyla yürütülmektedir. Uzatma ağı ve paragat balıkçılığında yakalanan balık ve omurgasızlar Ege ve Akdeniz’in yerleşik tipik balıklarıdır. Mullus barbatus, Sphyraena sphyraena, Seriola dumerilii, Pagellus erythrinus, Dentex dentex, Mullus surmuletus, Sarda sarda, Xiphias gladius, Epinephelus aeneus, Loligo vulgaris, Octopus vulgaris vb. ticari avdaki hedef türlerdir. Fakat bölgedeki balıkçılık aktiviteleri kısa balıkçılık sezonu, düşük balıkçılık kapasitesi ve az sayıdaki balıkçı nedeniyle göreceli olarak oldukça zayıf bulunmuştur

  14. Present attitudes of physical education students towards future employment in their profession [Současné názory studentů tělesné výchovy na jejich budoucí zaměstnání v této profesi

    Directory of Open Access Journals (Sweden)

    Magdalena Majer

    2010-06-01

    Full Text Available OBJECTIVE: The aim of the research was to examine empirically the attitudes of physical education students towards their future profession in physical culture and some of their considerations about the choice of their field of study and their opinion about the course of studies. METHODS: The research embraced physical education students studying at the Academy of Physical Education in Cracow. The research took place in two stages (May 2005 and 2008. The first part involved first year students (N = 162, the second the same students then being fourth year students, but only those, who passed all semesters on time (N = 103. The students' attitudes towards their future profession were examined by means of a questionnaire worked out by Grabowski and Skrzypiec. RESULTS: For 45.6% of our respondents the choice of their field of study and prospective profession was determined by positive factors. More than half of the tested students (51.6% chose physical education as their field of study because of their interests and passion. Salary, stability and terms of work are also significant factors. More than half of the respondents declare their willingness to work in their profession after graduation. CONCLUSIONS: From among the values preferred while choosing the physical educator's profession, passion was the main choice of the respondents, regardless of gender. The fact that their studies' positive influence on the respondents' attitudes towards their future profession decrease clearly between the first and the last year of studies, is alarming. It would be advisable to do more detailed research in other schools to verify the educational system and the practical preparation of prospective physical education teachers.[CÍLE: Cílem výzkumu bylo empiricky posoudit názory studentů tělesné výchovy na jejich budoucí zaměstnání v tělesné výchově a některé z důvodů, proč si vybrali tento studijní obor, a jejich názory na průběh studia

  15. Mobilní přístup k datům z automatizačních prvků (vývoj Back-End části aplikace)

    OpenAIRE

    Habarta, Lukáš

    2016-01-01

    Tato bakalářská práce se zabývá průzkumem a popisem technologií použitých při vývoji mobilní aplikace. Dále návrhem a implementací mobilního přístupu k datům z automatizačních prvků. Aplikace pracuje se servery založenými na standardu OPC Foundation Classic. This bachelor thesis is concerning about research and description of technologies which were used for mobile application development. Design and implementation of mobile accessing of automation data is also discussed. Application works...

  16. BEST PRACTICES FIREM A JEJICH TRANSFER

    Directory of Open Access Journals (Sweden)

    Jena Švarcová

    2013-10-01

    Full Text Available Learning organization and knowledge-based firm are challenges of the beginning of the 21st century. The new paradigm involves new questions and new tasks. We speak about human capital of the firm and its development, but who is owner of the capital? How can we develop and use the capital effectively and where is the border between individual development and learning of the firm as a complex? How can we measure the contributions of the knowledge development? This contribution can not answer such range of complex questions. The foundation for specific research activities was set by the involvement of Tomas Bata University in Zlin in the Europe Union projects of human resource development. Tomas Bata University in Zlin managed to win a new project within the framework of the Operational Programme for Human Resources Development, for Creating and Testing of a New Programme for Further Education at Universities entitled Work Smarter. Partner of the University in this project is Brno University of Technology, Faculty of Business and Management. The first part of the project was focused on the research of the needs of the enterprises and their employees in HRD and this contribution analyses the first results. The project is focused on the transfer of knowledge among the Czech small and medium enterprises. Universities help to this process with their professional staff and facilities. The mission of this project is to bring up and enforce innovative approaches and methods in Human and Resource Development (HRD in the Czech small and medium enterprises, to create a “learning environment” and to exercise the concept of lifelong learning in day-to-day practice of our enterprises. The first part of the project was focused on the research of the needs of the enterprises and their employees in HRD and the universities prepared a lot of videos from the enterprises and database of best practices. Then the e-Learning environment was prepared and tested in the specific conditions of the Czech enterprises. The last part of the project is focused on the wide use of the case studies and knowledge. The transfer of knowledge (the best practices as development of human capital of the firm is important as the cooperation of the research team with top managers of the Czech successful enterprises has confirmed. The workshops helped to create the list of 50 important topics for training of employees. The following selection has chosen 30 core topics and they were offered to employees of randomly chosen small and medium enterprises. The research with employees affirmed that such training is possible and the employees accepted most of the offered topics as contributing both the firm knowledge development and their individual development. The research was focused on the barriers on the recipient’s part; especially the potential lack of motivation and the lack of absorptive capacity. The results of the research confirmed that the motivation of employees is conditioned by the possibility of potential contribution of the training (transferring best practices for their individual development. The contributions only for the development of the firm knowledge capital are not sufficient for the employee’s motivation.

  17. Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats.

    Science.gov (United States)

    Maggio, Sarah E; Saunders, Meredith A; Baxter, Thomas A; Nixon, Kimberly; Prendergast, Mark A; Zheng, Guangrong; Crooks, Peter; Dwoskin, Linda P; Slack, Rachel D; Newman, Amy H; Bell, Richard L; Bardo, Michael T

    2018-05-01

    Co-users of alcohol and nicotine are the largest group of polysubstance users worldwide. Commonalities in mechanisms of action for ethanol (EtOH) and nicotine proposes the possibility of developing a single pharmacotherapeutic to treat co-use. Toward developing a preclinical model of co-use, female alcohol-preferring (P) rats were trained for voluntary EtOH drinking and i.v. nicotine self-administration in three phases: (1) EtOH alone (0 vs. 15%, two-bottle choice), (2) nicotine alone (0.03 mg/kg/infusion, active vs. inactive lever), and (3) concurrent access to both EtOH and nicotine. Using this model, we examined the effects of (1) varenicline, a nicotinic acetylcholine receptor (nAChR) partial agonist with high affinity for the α4β2* subtype; (2) r-bPiDI, a subtype-selective antagonist at α6β2* nAChRs; and (3) (R)-modafinil, an atypical inhibitor of the dopamine transporter (DAT). In phases 1 and 2, pharmacologically relevant intake of EtOH and nicotine was achieved. In the concurrent access phase (phase 3), EtOH consumption decreased while nicotine intake increased relative to phases 1 and 2. For drug pretreatments, in the EtOH access phase (phase 1), (R)-modafinil (100 mg/kg) decreased EtOH consumption, with no effect on water consumption. In the concurrent access phase, varenicline (3 mg/kg), r-bPiDI (20 mg/kg), and (R)-modafinil (100 mg/kg) decreased nicotine self-administration but did not alter EtOH consumption, water consumption, or inactive lever pressing. These results indicate that therapeutics which may be useful for smoking cessation via selective inhibition of α4β2* or α6β2* nAChRs, or DAT inhibition, may not be sufficient to treat EtOH and nicotine co-use.

  18. Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder: The additive and subtractive effect of the three dopaminergic genes - DRD2, D{beta}H, and DAT1

    Energy Technology Data Exchange (ETDEWEB)

    Comings, D.E.; Wu, S.; Chiu, C.; Ring, R.H.; Gade, R.; Ahn, C.; Dietz, G.; Muhleman, D. [Hope Medical Center, Duarte, CA (United States)] [and others

    1996-05-31

    Polymorphisms of three different dopaminergic genes, dopamine D{sub 2} receptor (DRD2), dopamine {beta}-hydroxylase (D{beta}H), and dopamine transporter (DAT1), were examined in Tourette syndrome (TS) probands, their relatives, and controls. Each gene individually showed a significant correlation with various behavioral variables in these subjects. The additive and subtractive effects of the three genes were examined by genotyping all three genes in the same set of subjects. For 9 of 20 TS associated comorbid behaviors there was a significant linear association between the degree of loading for markers of three genes and the mean behavior scores. The behavior variables showing the significant associations were, in order, attention deficit hyperactivity disorder (ADHD), stuttering, oppositional defiant, tics, conduct, obsessive-compulsive, mania, alcohol abuse, and general anxiety - behaviors that constitute the most overt clinical aspects of TS. For 16 of the 20 behavior scores there was a linear progressive decrease in the mean score with progressively lesser loading for the three gene markers. These results suggest that TS, ADHD, stuttering, oppositional defiant and conduct disorder, and other behaviors associated with TS, are polygenic, due in part to these three dopaminergic genes, and that the genetics of other polygenic psychiatric disorders may be deciphered using this technique. 144 refs., 2 figs., 13 tabs.

  19. Korelace sportovní aktivity a stravovacích návyků u dětí předškolního věku a jejich rodičů The correlation of sports activity and eating habits in preschool children and their parents

    Directory of Open Access Journals (Sweden)

    Jera Zajec

    2006-02-01

    Full Text Available Cílem výzkumu bylo analyzovat sportovní aktivitu a stravovací návyky u dětí předškolního věku a jejich rodičů. Zajímala nás korelace mezi stravovacími návyky rodičů a dětí předškolního věku a sportovní aktivitou. Pro dotazování 93 rodičů tří až pětiletých dětí ze tří slovinských školek byl použit dotazník obsahující 32 otázek. Údaje byly zpracovány programem SPSS, který počítá frekvenci a kontingenční tabulky. Zjistili jsme, že výživa většiny dětí předškolního věku je pravidelná a vhodná, přestože některé pětileté dívky a tříletí chlapci mají zvýšený BMI (index tělesné hmotnosti. Stravovací návyky rodičů však nejsou ani zdaleka vzorné – přes 50 % má pouze 2 až 3 jídla denně. Přestože nebyla potvrzena žádná statisticky charakteristická korelace, výsledky ukazují, že děti, jejichž rodiče jsou sportovně aktivní, mají vhodnější výživu než děti, jejichž rodiče sportovně aktivní nejsou. Statisticky charakteristické je, že rodiče, kteří jsou sportovně aktivnější, zapojují své děti do sportu ve větší míře. Většina z nich rovněž tráví aktivně prázdniny. Domníváme se, že v době, kdy ještě podléhají vlivu rodičů a učitelů, by děti měly přijmout pozitivní přístup ke sportovně aktivnímu způsobu života a zdravé výživě, které představují základní podmínku normálního způsobu života bez zbytečných problémů způsobených škodlivými návyky a civilizačními chorobami. The aim of this research was to analyze sports activity and eating habits in preschool children and their parents. We were interested in the correlation between parents' and preschool childrens' eating habits and sports activity. A questionnaire consisting of 32 questions was used to interview 93 parents of three to five year old children from 3 Slovene kindergartens. The data was processed by the SPSS program

  20. Spojování dat

    OpenAIRE

    Janíková, Veronika

    2014-01-01

    This bachelor's thesis deals with a data fusion, which is a one of the possible solutions to the common problem of data availability in praxis. In the first part, practical use of data fusion, especially in marketing, fundamental algorithms and data fusion problems are discussed. The main part of this thesis deals with the so-called "unconstrained statistical fusion". Firstly, one of the possible processes of this type of fusion is described theoretically in detail. This process involves bran...

  1. Levend of dood, dat is de vraag!

    NARCIS (Netherlands)

    Lee, van der T.A.J.; Leeuwen, van G.; Haan, de E.; Helder, J.; Koenraadt, H.; Bonants, P.J.M.

    2011-01-01

    In de literatuur zijn voor de detectie van plantenpathogenen diverse methodieken beschreven. De biologische methodieken detecteren alleen levende organismen. Morfologische, serologische en moleculaire technieken maken mmestal geen onderscheid tussen dood en levend of infectieus en niet infectieus.

  2. Coordination skills in 9 to 11 years old pupils at practical elementary schools in relationship to their degree of intellectual disability [Úroveň vybraných koordinačních schopností 9-11letých žáků základních škol praktických v závislosti na stupni jejich mentálního postižení

    Directory of Open Access Journals (Sweden)

    Alena Lejčarová

    2009-12-01

    (including motivation and by the environment they live in. [VÝCHODISKA: Za jedno z hlavních kritérií nezbytné vnitřní diferenciace tělovýchovného procesu na základních školách praktických je považován stupeň mentálního postižení žáků. Doposud však dětem s mentálním postižením, resp. žákům základních škol praktických nebyl v tomto ohledu věnován dostatek pozornosti jak v oblasti výzkumného bádání, tak v tělovýchovné praxi. CÍLE: Cílem realizované studie bylo zjistit úroveň vybraných koordinačních schopností 153 žáků (ve věku 9–11 let na základních školách praktických v Praze s ohledem na stupeň jejich mentálního postižení. METODIKA: K posouzení úrovně vybraných koordinačních schopností bylo použito sedm motorických testů (rytmické, rovnováhové, kinesteticko-diferenciační schopnosti, schopnosti přestavby a sdružování. VÝSLEDKY: Téměř naprosto jednoznačně byly věcně významné rozdíly (užitím Cohenova koeficientu d prokázány mezi žáky s intelektovými schopnostmi v oblasti dolní hranice lehkého mentálního postižení a ostatními s výjimkou těch, jejichž intelektové schopnosti se pohybují na horní hranici lehkého mentálního postižení, a dále mezi těmito žáky a ostatními (hluboký intelektový podprůměr, lehký intelektový podprůměr, průměrné intelektové schopnosti - nižší průměr. Z hlediska průměrných hodnot motorických výkonů lze sledovat jejich přímou vazbu k míře mentálního postižení - klesají s jejím růstem. Nejlepší testová skóre byla překvapivě zaregistrována u žáků s lehkým intelektovým podprůměrem, a nikoliv u žáků s nejvyšší úrovní intelektových schopností. ZÁVĚRY: Rozdílné výsledky v motorických testech žáků základních škol praktických nejsou ryze kauzálně závislé pouze na stupni mentálního postižení, ale i na jeho etiologii. Rovněž je ovlivňují i specifika

  3. Shifting renewable energy in transport into the next gear. Developing a methodology for taking into account all electricity, hydrogen and methane from renewable sources in the 10% transport target; Hernieuwbare energie in transport naar een hogere versnelling. Ontwikkeling van een methode dat rekening houdt met alle elektriciteit, waterstof en methaan uit hernieuwbare bronnen in de 10% transportdoelsteling

    Energy Technology Data Exchange (ETDEWEB)

    Kampman, B.; Leguijt, C.; Bennink, D. [CE Delft, Delft (Netherlands); Wentrup, K.; Dreblow, E.; Gruenig, M. [Ecologic Institute, Berlin (Germany); Schmidt, P.; Wurster, R.; Weindorf, W. [Ludwig-Boelkow-Systemtechnik, Muenchen-Ottobrunn (Germany)

    2012-01-15

    vastgesteld dat 10% van alle in de transportsector gebruikte energie in 2020 uit hernieuwbare bronnen moet komen. De richtlijn schrijft ook voor welke berekeningsmethoden in deze context gebruikt dienen te worden voor de biobrandstoffen en hernieuwbare elektriciteit die door voertuigen worden gebruikt. Bij biobrandstoffen worden alleen die brandstoffen in de berekening meegenomen die feitelijk in de transportsector worden gebruikt. Voor de bijdrage van elektriciteit uit hernieuwbare bron wordt een iets anders methode gebruikt, omdat deze gewoonlijk aan het elektriciteitsnet wordt onttrokken, waarbij de precieze herkomst van de gebruikte energie niet wordt bijgehouden: in hun berekeningen worden lidstaten daarom geacht het gemiddelde aandeel van hernieuwbare elektriciteit hiervoor te gebruiken. De Richtlijn schrijft ook voor dat, wanneer dat nodig mocht blijken, de Europese Commissie een voorstel moet presenteren waarin wordt aangegeven hoe de totale hoeveelheid door elektrische voertuigen gebruikte hernieuwbare elektriciteit berekend dient te worden en een methodologie wordt gegeven om de bijdrage van waterstof uit hernieuwbare bronnen in de transportsector op te nemen. Daarnaast is er de vraag hoe biomethaan dat in het aardgasnet wordt ingebracht in de 10%-transportdoelstelling moet worden verdisconteerd wanneer voertuigen uit datzelfde net worden gevuld - via een route die vergelijkbaar is met die van elektriciteitsgebruik in de transportsector. Door DG Energie van de Commissie zijn CE Delft, Ecologic Institute en Ludwig-Bölkow-Systemtechnik (LBST) gevraagd ondersteuning te bieden bij het besluitvormingstraject rondom de drie genoemde routes voor transportenergie: hernieuwbare elektriciteit, waterstof en biomethaan, waarbij distributie via landelijke netten plaatsvindt. Dat heeft geleid tot een uitgebreid rapport waarin verschillende methodologische opties worden uitgewerkt en beoordeeld en conclusies worden getrokken voor zowel de korte en middellange termijn (tot 2020

  4. Nástroje Business Intelligence a jejich implementace v podniku

    OpenAIRE

    Ubr, Michal

    2014-01-01

    Tato práce se zabývá analýzou nástrojů spojených s business intelligence ve vybraném podniku ŽĎAS a. s. a následným vypracováním návrhu na zlepšení jednotlivých součástí a služeb spadajících do této oblasti. Práce se zaměřuje především na finanční úsek podniku, ve kterém jsou nástroje BI nejvíce využívány. This thesis deals with the analysis of tools related to business intelligence in a selected company ŽĎAS a. s. and subsequent elaboration of draft to improve individual components and se...

  5. Lidská práva a jejich zdroje

    OpenAIRE

    SILOVSKÁ, Marcela

    2010-01-01

    The thesis deals with the theme of human rights. It offers a basic survey of the development of human rights. It explores a historical development of human rights and contemporary conception of this term. It analyses sources of human rights and documents on human rights; it focuses on protection of human rights in the World. The fourth chapter focuses on protection of human rights in the Czech Republic and on the activity of non-governmental organizations working in the field of human rights ...

  6. Historické povodně a jejich dokumentace

    Czech Academy of Sciences Publication Activity Database

    Munzar, Jan; Ondráček, Stanislav

    2012-01-01

    Roč. 21, č. 5 (2012), s. 30-32 ISSN 1210-3004 Institutional support: RVO:68145535 Keywords : historical floods * Czech lands * flood documentation Subject RIV: AB - History http:// geography .cz/geograficke-rozhledy/obsah-215-udolni-niva-243/gr-2011-2012-21-5-udolni-niva/

  7. Vztah mezi úspěšností dětí v předplavecké výchově, jejich temperamentovými charakteristikami a stimulací k pohybovým aktivitám Relationship between children's successfulness in pre-swimming education, their temperament characteristics and stimulation to physical activities

    Directory of Open Access Journals (Sweden)

    Ludmila Miklánková

    2006-02-01

    Full Text Available Cílem studie bylo posoudit a zhodnotit možnost ovlivnění úspěšnosti dětí předškolního věku v kurzu předplavecké výchovy některými vnějšími a vnitřními faktory. Zaměřili jsme se na úroveň environmentální stimulace k pohybovým aktivitám ze strany rodiny a školy a na rysy temperamentu sledovaných dětí. Do výzkumného souboru bylo zahrnuto 83 dětí – neplavců z mateřských škol, úplné výsledky se podařilo získat u 58 dětí (30 dívek a 28 chlapců. Průměrný věk sledovaného souboru byl 5.87 roku. Míra úspěšnosti dítěte v kurzu předplavecké výchovy, zaměřeném na výuku základních plaveckých dovedností, byla hodnocena pomocí standardizované pětisložkové testové baterie (Řehoř, 1969. Na základě výsledků byly děti zařazeny do tří skupin: U1 – velmi úspěšní, U2 – úspěšní, U3 – neúspěšní. Rysy temperamentu byly zjištěny prostřednictvím Eysenckova dotazníku (Müllner & Senka, 1987. Pro posouzení environmentální stimulace k pohybovým aktivitám jsme užili dotazníku ESPA (Renson & Vanreusel, 1990; Miklánková, 2005. Hodnocení souvislosti mezi stimulací k pohybovým aktivitám a úspěšností dětí v kurzu předplavecké výchovy bylo provedeno Mann-Whitney testem. Vztah mezi úspěšností probandů v předplavecké výchově a jejich typem temperamentu byl hodnocen analýzou variance, případně metodou Kruskal-Walis. Při porovnání stimulace k pohybovým aktivitám mezi skupinami s rozdílnou úspěšností v předplavecké výchově (mezi skupinami U1 a U2, U2 a U3 byl nalezen signifikantní rozdíl (p < 0.01 u jednoho ze stimulů sociální participace. Srovnání mezi skupinami U1, U2 a U3 potvrdilo statisticky významný rozdíl v dimenzi extraverze mezi skupinou U1 a U3 (p < 0.01 a mezi skupinou U1 a U2 (p < 0.05. Skupina U3, která dosáhla v testech plavecké úspěšnosti nejhorších výsledků, se signifikantně odlišuje od

  8. The verification of the usability of the online Indares.com system in collecting data on physical activity – pilot study [Ověření využitelnosti online systému Indares.com pro sběr dat o pohybové aktivitě – pilotní studie

    Directory of Open Access Journals (Sweden)

    Josef Mitáš

    2008-05-01

    Full Text Available In order to reduce the increase of obesity and an inactive healthy lifestyle in the population, we are seeking means which would enhance a change in physical activity behavior worldwide. Information technologies, especially the internet, are among these means. Research has shown internet intervention to be effective in enhancing health in the population. The aim of the pilot study is to verify the usability of the online Indares.com system in collecting data on physical activity (PA and at the same time to analyze a possible use of the system for intervention programs. The verification of the Indares.com system was carried out in the spring term (from January to May 2008 in a sample of 114 students at Valdosta State University who recorded their PA regularly into the system. The study analyzed the data from the first 12 weeks of the semester. The results show that the Indares.com system is an effective tool for the online collection of data on PA in its users and that the recorded data can be used for research purposes. Furthermore, the obtained information suggests that the Indares.com system can be used in internet intervention programs. [Ve snaze zmírnit trend nárůstu obezity a inaktivního způsobu života populace jsou celosvětově hledány prostředky, které by přispěly k žádoucí změně pohybového chování lidí. Mezi tyto prostředky patří moderní informační technologie, zejména internet. Dosavadní výzkumy spíše potvrzují efektivnost internetových intervencí zacílených na zdraví populace. Cílem této pilotní studie bylo ověřit praktickou využitelnost internetové aplikace Indares.com ke sběru dat o pohybové aktivitě (PA a současně analyzovat možnosti využití systému pro intervenční programy. Ověřování systému Indares.com bylo uskutečněno během jarního semestru (leden až květen 2008 na 114 studentech Valdosta State University, kteří svou PA pravidelně zapisovali do systému. V t

  9. Stoppen met roken: hoe pakken wij dat aan?

    NARCIS (Netherlands)

    Jacobs-van der Bruggen, M.; Donker, G.; Verkleij, H.; Baan, C.

    2007-01-01

    Background: Smoking is the cause of a great deal of morbidity and mortality. General practitioners (GPs) can help prevent smoking-related diseases by following an active anti-smoking policy, i.e. by taking the initiative to discuss stopping smoking with their patients. The aim of our research is to

  10. The European Social Survey (ESS): o projektu a dostupnosti dat

    Czech Academy of Sciences Publication Activity Database

    Plecitá, Klára; Kalvas, František

    2005-01-01

    Roč. 7, č. 2 (2005), s. 14-16 ISSN 1212-995X R&D Projects: GA MŠk(CZ) 1N04192 Institutional research plan: CEZ:AV0Z70280505 Keywords : ESS * data accesibility * data services Subject RIV: AO - Sociology, Demography

  11. 'Dat kan beter, ja...' : Webcare en het voorkomen van reputatieschade

    NARCIS (Netherlands)

    Renée van Os; Daphne Hachmang

    2018-01-01

    Klanten uiten op social media steeds vaker hun ongenoegen over de diensten of producten die bedrijven aanbieden. Het effect op de reputatie van uw organisatie kan desastreus zijn, zeker wanneer u niet, of op de verkeerde manier, reageert. Tegelijkertijd kan één positieve recensie van een klant op

  12. Groter geluk voor een groter aantal. Kan dat in Nederland?

    NARCIS (Netherlands)

    R. Veenhoven (Ruut)

    2007-01-01

    textabstractWat is de taak van de overheid? Volgens Jeremy Bentham (1789) uiteindelijk om groter geluk voor een groter aantal burgers te bewerkstelligen. Hij vatte geluk daarbij op als individuele levensvoldoening: in zijn woorden als "the sum of pleasures and pains". In zijn tijd kon geluk nog niet

  13. Waarom Jahwe weier dat Dawid die tempel bou

    Directory of Open Access Journals (Sweden)

    J. L. Helberg

    1990-06-01

    Full Text Available Jahweh’s refusal of David's intended building of the temple (2 Sam. 7 does not reflect a nomadic ideal but rather stresses that Israel should not be concerned with a human kingdom, one in which the idea of a human king (and prophet has the highest authority. The initiative lies in the Word and action of Jahweh; He is the real Sovereign, and the king is his servant. The human kingdom, with its human insight, planning and action is imperfect and crooked, even though it be that of the king (and prophet. The human kingdom therefore needs a divine corrective (as in 1 Sam. 2:1-10; 8; 1 Sam. 11 ff., 23, 24. The refusal further stresses that Jahweh is not a God who is confined to a building or the cult. The essence of true religion does not consist in fulfilling cultic duties but centres in personal communication with God in all aspects of life. Serving God is the fruit of divine election and covenant loyalty. True service of God is brought about by God’s corrective Word by which He constantly calls for repentance and in fact also generates it.

  14. Detekce provozu Skype pomocí dat NetFlow

    OpenAIRE

    Šebeň, Patrik

    2012-01-01

    NetFlow je sieťový protokol bežne používaný k zberu informácií o IP tokoch. Avšak existuje možnosť, ako použiť tieto zachytené dáta k identifikácií klientov v Skype komunikácií. Táto práca pojednáva o identifikácií určitých vzorov v Skype protokole a ich detekcií v NetFlow dátach. Týmto spôsobom sme schopný identifikovať nódy a supernódy v sieti Skype. NetFlow is a network protocol commonly used for collectiong IP traffic information. But there is a way to use this collected data for inden...

  15. Submarine Biofouling Control- Chlorination DATS Study at Pearl Harbor

    National Research Council Canada - National Science Library

    Wegand, John

    2001-01-01

    The intent of this document is to sumarize the chlorination studies performed at Naval Station, Pearl Harbor in support of biofouling control initiatives for the submarine community, as requested by NAVSEA 92T...

  16. Waer een steen so breet dat hi al eertrijck besloech

    DEFF Research Database (Denmark)

    Robbe, Joost Roger

    2014-01-01

    and Vliederhoven’s and Van Rijkel’s Latin versions can only be explained by the influence of the Middle Dutch translation of the Horologium, whereby the transition from ‘zadeken’ (seed) to ‘zandeken’ (sand) in the Middle Dutch translation led to the introduction of a sand stone or sand mount in the versions...... of Vliederhoven and Van Rijkel respectively. In this way, the reception of Suso’s allegory in the Netherlands in the 15th century represents an illuminative example of how Latin texts could both influence and be influenced by vernacular literature....

  17. The 1975 DAtF-KTG reactor conference in Nuernberg

    International Nuclear Information System (INIS)

    Henssen, H.; Rossbach, W.

    1975-01-01

    A comprehensive review on the meeting is given which reports on the most important of the 204 papers read in the four session groups: 1) reactor design and experiments, 2) fuel elements, fuel cycle, and isotope technique, 3) planning, construction and operation of nuclear reactor facilities and their components, and 4) reactor types and problems of cost-efficiency. (UA/AK) [de

  18. Management sociálněvědních dat a cyklus života dat

    Czech Academy of Sciences Publication Activity Database

    Krejčí, Jindřich

    2011-01-01

    Roč. 9, č. 12 (2011), s. 1-4 ISSN 1214-1720 R&D Projects: GA MŠk LA09010 Institutional research plan: CEZ:AV0Z70280505 Keywords : survey research * data management * data life cycle Subject RIV: AO - Sociology, Demography http://www.socioweb.cz/upl/editorial/download/196_SOCIOWEB_12_2011.pdf

  19. Lower cost, more comfort. Simulation software for interactive building sessions; Lagere kosten, meer comfort. Simulatiesoftware maakt weg vrij voor interactieve bouwsessies Steeds meer opdrachtgevers en projectontwikkelaars realiseren zich dat de levensduurkosten van een gebouw een veelvoud van de investering kunnen zijn. Om beslissingen te kunnen nemen die deze kosten kunnen bemvloeden is het belangrijk om al in de ontwerpfase met het complete (bouw)team verschillende alternatieven door te rekenen. Een gebouwsi- mulatiesysteem kan hierbij uitkomst bieden.

    Energy Technology Data Exchange (ETDEWEB)

    Lankhoorn, B. [Schouten Techniek, Zwaag (Netherlands)

    2012-12-15

    More and more clients and project developers realize that the life cycle cost of a building can be a multiple of the investment. To be able to make the right decision to lower the cost it is important to calculate different alternatives already in the design phase with the complete (construction) team. A building simulation system can be the solution [Dutch] Steeds meer opdrachtgevers en projectontwikkelaars realiseren zich dat de levensduurkosten van een gebouw een veelvoud van de investering kunnen zijn. Om beslissingen te kunnen nemen die deze kosten kunnen bemvloeden is het belangrijk om al in de ontwerpfase met het complete (bouw)team verschillende alternatieven door te rekenen. Een gebouwsi- mulatiesysteem kan hierbij uitkomst bieden.

  20. BİR AMERİKALI DİPLOMATIN GÖZÜYLE BAĞDAT DEMİR YOLU PROJESİ (ABD SİVAS KONSOLOSU HENRY M. JEWETT’İN RAPORU - THE PROJECT OF BAGHDAD RAILWAY THROUGH AMERICAN DIPLOMAT’S EYE (THE REPORT OF U.S. SİVAS CONSUL, HENRY M. JEWETT

    Directory of Open Access Journals (Sweden)

    Osman Kubiƒlay GÜL

    2014-03-01

    Full Text Available ÖzetDemir yolunun yaygınlaşmaya başlamasıyla birlikte Osmanlı Devleti de çağdaş dünyanın bu nimetinden faydalanmak istemiştir. Demir yolu sayesinde ekonomisini düzeltebileceği gibi, taşradaki otoritesini de kuvvetlendirebileceğini düşünmektedir. Kendisinin demir yolu projelerini hayata geçirmek için yeterince sermaye ve bilgi birikimine sahip olmaması, bu konuda Avrupalı devletlere başvurmasını zorunlu kılmıştır.Demir yolu teknolojisine sahip devletler, Osmanlı toprakları üzerinde hatlar oluşturma düşüncesine olumlu yaklaşmışlardır. Bu hatlar sayesinde ham maddeye ulaşımlarını kolaylaştıracakları gibi, üretimleri için de kendilerine kolay ulaşabilecekleri pazarlar açmayı hedeflemişlerdir.Bağdat Demiryolu Projesi, yukarıda bahsettiğimiz nedenlerden dolayı hem Osmanlı hem de Avrupalı devletler için önem arz etmektedir. İngiltere, Fransa ve Almanya arasında imtiyazı elde etme mücadelesi yaşanmıştır. Bu mücadele arasında Amerika Birleşik Devletleri de Anadolu’ya ilgi duymaya başlamıştır. İlk olarak misyonerler aracılığı ile tanımaya başladığı Anadolu’da daha sonraları konsolosluklar açarak ciddi bir teşkilatlanmaya gitmiştir. Konsoloslarının verdiği raporlarla Anadolu’nun yer altı ve yer üstü zenginliklerinin haberdar olmuştur.Henry M. Jewett, Amerika Birleşik Devletleri’nin Sivas Konsolosudur. Bağdat Demir Yolu Projesi ortaya çıktığında ülkesi, kendisinden hattın geçeceği yerlerle ilgili bir rapor istemiştir. O da Bolu’dan başlayarak Bağdat’a kadar demir yolunun geçme ihtimalini yüksek gördüğü önemli yerleşim merkezlerini, yer altı ve yer üstü kaynakları açısından incelemiş ve ülkesine bir rapor hâlinde sunmuştur. Bu merkezlerdeki yer altı ve yer üstü zenginlikleri, ticaret olanakları ve nüfusları ile ilgili istatistikler de raporda yer almıştır.AbstractOttoman Empire also wanted to benefit from

  1. Historiografie biologie a jejich grande dame Ilse Jahnová (1922-2010)

    Czech Academy of Sciences Publication Activity Database

    Hermann, Tomáš; Šimůnek, Michal V.

    2010-01-01

    Roč. 43, č. 4 (2010), s. 249-254 ISSN 0300-4414 R&D Projects: GA ČR GPP410/10/P550 Institutional research plan: CEZ:AV0Z80630520 Keywords : Ilse Jahn * historiography of biology * history of science Subject RIV: AB - History

  2. Specifické poruchy učení a jejich náprava

    OpenAIRE

    Matějková, Veronika

    2009-01-01

    The aim of my thesis is to obtain an insight into the field of specific learning disabilities. The thesis has the character of a summary and it mainly concerns the comparison of existing knowledge and approaches to children with specific learning disabilities. This thesis should be used not only for academical purposes; it also should enable the reader to underestand the term, cause, symptoms, reeducation of specific learning disabilities, which improves the understanding of the life of peopl...

  3. Deportace do Niska nad Sanem a jejich místo v historii holocaustu

    OpenAIRE

    Borák, Mečislav

    2010-01-01

    The first mass transports of Jews in Nazi–occupied Europe pulled out from Moravská Ostrava, Vienna and Katowice. They headed for Nisko nad Sanem in the eastern part of occupied Poland where the Jews, under the supervision of the SS guards, were supposed to build a concentration camp. This enterprise was administered by Adolf Eichmann and it affected about five thousand Jews from Bohemia, Poland and Austria. The SS guards drove the majority of prisoners to the Soviet Union where they were impr...

  4. Výživové zvyklosti a jejich vliv na tělesnou stavbu.

    OpenAIRE

    Chmelařová, Veronika

    2012-01-01

    Nutrition is to ensure nutrients needed to sustain life activity, healthy growth and reproduction. Good healthy food can improve the quality and length of life. Positive effects intensify if the diet is combined with other elements of a healthy lifestyle: fresh air, physical activity, rest, avoiding toxic substances and a good mental state. In the Czech Republic there are changes in eating habits in the last 20th years. The food consumption was a major coup in the volume and in the structure....

  5. Imperativy slovesa počkat a jejich úloha v organizaci diskurzu

    Czech Academy of Sciences Publication Activity Database

    Kopřivová, Marie

    2017-01-01

    Roč. 100, č. 5 (2017), s. 281-293 ISSN 0027-8203 R&D Projects: GA ČR GA15-01116S Institutional support: RVO:68378092 Keywords : imperative of the verb to wait * conversation * spoken language corpora * Czech in the media * overlaps Subject RIV: AI - Linguistics OBOR OECD: Linguistics

  6. Role královny a jejich reflexe ve Zbraslavské kronice

    Czech Academy of Sciences Publication Activity Database

    Vejrychová, Věra

    2015-01-01

    Roč. 7, č. 1 (2015), s. 55-79 ISSN 1804-0977 R&D Projects: GA ČR(CZ) GBP405/12/G148 Institutional support: RVO:67985955 Keywords : Queenship * political power * gender role s * ideal reign * Zbraslav Chronicle Subject RIV: AB - History

  7. Klasifikace nákladů a možnosti jejich analýzy

    OpenAIRE

    PUDIL, Jan

    2008-01-01

    The theme of this Bachelor´s essay is costs classification and possibility of their analyse. This work is divided into four parts: the sense of costs monitoring, costs classification and their record, possibility of costs analyse and real costs analysis. First part deals with importance of costs monitoring, what costs affect. Second part reflects costs classification meanly different position and their record. Third part is about possible methods of costs analyse. Final part contains process ...

  8. Nootropika a molekulární mechanismy jejich působení

    OpenAIRE

    Staněk, Petr

    2015-01-01

    Nootropics have become the standart in the field of treating memory impairments and decline of cognition which are still more frequent problem when we consider aging of population in the western world. To better understand the capabilities and dangers of these drugs, it is necessary to widen our knowledge of the mechanism of their action. In this thesis I focus on the nootropics with the widespread use across the world (nicotine, caffeine) and on the drugs with long clinical prescription hist...

  9. Mikroorganismy a možnosti jejich separace, detekce a identifikace

    Czech Academy of Sciences Publication Activity Database

    Horká, Marie; Šalplachta, Jiří; Roth, Michal

    2014-01-01

    Roč. 93, č. 3 (2014), s. 138-139 ISSN 0042-4544 R&D Projects: GA MV VG20112015021; GA MV VG20102015023 Institutional support: RVO:68081715 Keywords : capillary isoelectric focusing * microorganisms * bacteria * electrophoretic techniques Subject RIV: CB - Analytical Chemistry, Separation

  10. HALOFYTNÍ ROSTLINY A JEJICH MOŽNÉ VYUŽITÍ VE FYTOREMEDIACÍCH

    Czech Academy of Sciences Publication Activity Database

    Moťková, Kateřina; Podlipná, Radka; Vaněk, Tomáš; Kafka, Z.

    2014-01-01

    Roč. 108, č. 6 (2014), s. 586-591 ISSN 0009-2770 R&D Projects: GA MŠk(CZ) OC10028 Institutional support: RVO:61389030 Keywords : halophytic plants * phytoremediation * heavy metals Subject RIV: DK - Soil Contamination ; De-contamination incl. Pesticides Impact factor: 0.272, year: 2014 http://www.chemicke-listy.cz/docs/full/2014_06_586-591.pdf

  11. Suita a Idylla Leoše Janáčka: jejich recepce a programnost

    Czech Academy of Sciences Publication Activity Database

    Zapletal, Miloš

    2017-01-01

    Roč. 55, č. 1 (2017), s. 57-77 ISSN 0018-7003 Institutional support: RVO:68378076 Keywords : Janáček * Suite * Idyll * programme music * music al hermeneutics * absolute music Subject RIV: AL - Art, Architecture, Cultural Heritage

  12. KOVOVÁ CHUŤ PŘÍRODNÍCH LÁTEK A JEJICH DERIVÁTŮ

    Czech Academy of Sciences Publication Activity Database

    Wimmer, Zdeněk; Opletal, L.; Čopíková, J.; Moravcová, J.; Abdulmanea, K. S. O.; Lapčík, O.; Drašar, P.

    2012-01-01

    Roč. 106, č. 10 (2012), s. 926-930 ISSN 0009-2770 Institutional research plan: CEZ:AV0Z50380511 Keywords : ARTIFICIAL SWEETENERS * PERCEPTION * IDENTIFICATION Subject RIV: GM - Food Processing Impact factor: 0.453, year: 2012 http://www.chemicke-listy.cz/common/article-vol_106-issue_10-page_926.html

  13. SLANÁ CHUŤ PŘÍRODNÍCH LÁTEK A JEJICH DERIVÁTŮ

    Czech Academy of Sciences Publication Activity Database

    Opletal, L.; Wimmer, Zdeněk; Čopíková, J.; Lapčík, O.; Moravcová, J.; Cahlíková, L.; Drašar, P.

    2011-01-01

    Roč. 105, č. 10 (2011), s. 761-765 ISSN 0009-2770 R&D Projects: GA MZe QI111A166 Institutional research plan: CEZ:AV0Z50380511 Keywords : PERCEPTION * SALTINESS * FOOD S Subject RIV: GM - Food Processing Impact factor: 0.529, year: 2011 www.chemicke-listy.cz/common/article-vol_105-issue_10-page_761.html

  14. FYTOREMEDIACE A MOŽNOSTI ZVÝŠENÍ JEJICH ÚČINNOSTI

    Czech Academy of Sciences Publication Activity Database

    Soudek, Petr; Petrová, Šárka; Benešová, Dagmar; Kotyza, J.; Vaněk, Tomáš

    2008-01-01

    Roč. 102, č. 5 (2008), s. 346-352 ISSN 0009-2770 R&D Projects: GA ČR GP522/06/P002; GA MŠk 1M06030 Institutional research plan: CEZ:AV0Z50380511 Keywords : ARABIDOPSIS-THALIANA * PHYTOREMEDIATION * PLANTS Subject RIV: CE - Biochemistry Impact factor: 0.593, year: 2008 www.chemicke-listy.cz/common/article-vol_102-issue_5-page_346.html

  15. Druhy pozemků a způsoby jejich využití

    Czech Academy of Sciences Publication Activity Database

    Kratěna, Jindřich

    2004-01-01

    Roč. 14, č. 1 (2004), s. 9-10 ISSN 1335-1133 R&D Projects: GA ČR GA103/97/S051 Institutional research plan: CEZ:AV0Z2071913 Keywords : covered area * garden * forest Subject RIV: JM - Building Engineering

  16. Online marketingové nástroje a jejich efektivita

    OpenAIRE

    Lesný, Tomáš

    2012-01-01

    The diploma thesis deals with internet marketing tools, the tools of own web pages and the tools of internet advertising. In connection with growing importance of internet marketing arises question how effective are internet marketing tools and what are their benefits. This thesis compares benefits and effectiveness to a sample of internet marketing tools based on the branch metrics and based on a Return On Investment. The research includes 10 apllied tools of internet marketing from 12 descr...

  17. Antická dramata Jaroslava Vrchlického a jejich dobová recepce

    Czech Academy of Sciences Publication Activity Database

    Čadková, Daniela

    2013-01-01

    Roč. 136, 1-2 (2013), s. 189-219 ISSN 0024-4457 Institutional support: RVO:67985955 Keywords : J. Vrchlický * drama * National Theatre * classical tradition Subject RIV: AJ - Letters, Mass-media, Audiovision

  18. Internetové start-up projekty a jejich rizika

    OpenAIRE

    Sládek, Pavel

    2014-01-01

    The goal of this thesis is to analyse the field of the Internet startups and to find out what trends and risks are associated with their development and launching. The first chapter of this thesis summarizes the main changes in recent years and the methodologies that are the most often used in developing of startups. The work also reflects a problem connected with financing, such as investor interest in emerging projects. Then there is explained how startup investing works and what opportunit...

  19. Pohádky K. J. Erbena. Problematika jejich zpracování

    Czech Academy of Sciences Publication Activity Database

    Otčenášek, Jaroslav

    Suppl., 14/2 (2011), s. 152-159 ISSN 1211-975X. [Karel Jaromír Erben a úloha paměťových institucí v historických proměnách. Malá Skála, 15.04.2011-16.04.2011] Institutional research plan: CEZ:AV0Z90580513 Keywords : Karel Jaromír Erben * fairy tales * folklore Subject RIV: AC - Archeology, Anthropology, Ethnology

  20. Patologie ledvin a jejich vyšetřovací metody

    OpenAIRE

    Špiková, Andrea

    2016-01-01

    Spikova Andrea Renal pathology and diagnostic methods Bachelor thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Field of study: Medical Laboratory Technician This thesis is focused on diagnostic methods in various renal diseases. The first part is devoted to the anatomy and physiology of the kidney, where is outlined how look and operate various parts of kidneys and also the whole organ. Next part si composed of analysis of the urine, where is described chemical anal...

  1. Deriváty triptycenu: Karboxylové kyseliny a jejich amidy

    Czech Academy of Sciences Publication Activity Database

    Rybáčková, Markéta; Bělohradský, Martin; Holý, Petr; Závada, Jiří; Císařová, I.

    2005-01-01

    Roč. 99, č. 5 (2005), s. 380-381 ISSN 0009-2770. [Mezioborové setkání mladých biologů, biochemiků a chemiků /5./. 15.06.2005-18.06.2005, Devět skal - Žďárské vrchy] R&D Projects: GA ČR(CZ) GA203/03/0087 Institutional research plan: CEZ:AV0Z40550506 Keywords : triptycene * carboxylic acids Subject RIV: CC - Organic Chemistry

  2. Kapradiny hornoslezské pánve a jejich spory in situ

    Czech Academy of Sciences Publication Activity Database

    Pšenička, J.; Bek, Jiří

    2009-01-01

    Roč. 2008, - (2009), s. 105-108 ISSN 0514-8057 R&D Projects: GA AV ČR(CZ) IAA300130503 Institutional research plan: CEZ:AV0Z30130516 Keywords : Upper Silesian Basin * Upper Carboniferous * ferns * in situ spores * spores Subject RIV: DB - Geology ; Mineralogy http://www.geology.cz/zpravy/obsah/2008/2008-30.pdf

  3. Strategické aliance a jejich role v České republice

    OpenAIRE

    Stelzigová, Tereza

    2017-01-01

    Bachelor thesis examines the situation of strategic alliances in the Czech Republic and their influence on small and medium enterprises. It evaluates the advantages or disadvantages that alliance membership brings to businesses and assess the impact of alliances on the competitiveness of enterprises. The thesis focuses more closely on export alliances supported by CzechTrade and clusters. The paper evaluates recommendations for small and medium enterprises to create effective cooperation with...

  4. Alozymy - jejich funkce, význam a použití

    Czech Academy of Sciences Publication Activity Database

    Plačková, Ivana

    2011-01-01

    Roč. 46, Mater. 25 (2011), s. 43-59 ISSN 1212-3323 R&D Projects: GA ČR GA206/07/0059; GA AV ČR IAA600050707; GA ČR GA206/08/0890 Institutional research plan: CEZ:AV0Z60050516 Keywords : allozymes * elektrophoresis * genetic variability Subject RIV: EF - Botanics

  5. Kladenské haldy, jejich význam, hodnota a možnosti revitalizace

    Czech Academy of Sciences Publication Activity Database

    Cílek, Václav

    2005-01-01

    Roč. 60, č. 7 (2005), s. 214-217 ISSN 1210-258X Institutional research plan: CEZ:AV0Z30130516 Keywords : spoil heaps * industrial landscape * revitalisation Subject RIV: DB - Geology ; Mineralogy http://www.casopis.ochranaprirody.cz/res/data/003/000478.pdf

  6. Einsteinovy rovnice a jejich vybrané důsledky

    Czech Academy of Sciences Publication Activity Database

    Málek, Tomáš; Pravda, Vojtěch; Pravdová, Alena

    2015-01-01

    Roč. 60, č. 3 (2015), s. 203-214 ISSN 0032-2423 Institutional support: RVO:67985840 Keywords : Einstein's theory of gravity * perihelion precession of Mercury * bending of light Subject RIV: BA - General Mathematics http://hdl.handle.net/10338.dmlcz/144416

  7. Exercises in statistics for HA & HA(dat.) & BSc(B), 3rd semester

    DEFF Research Database (Denmark)

    The booklet contains excercises to be used for the tutorials related to the 3rd semester course in statistics on the bachelors progarmme at the Aarhus School of Business.......The booklet contains excercises to be used for the tutorials related to the 3rd semester course in statistics on the bachelors progarmme at the Aarhus School of Business....

  8. No consensus for consensus's sake. Interview with DAtF-President Dr. Otto Majewski

    International Nuclear Information System (INIS)

    Anon.

    1999-01-01

    The German power industry is not prepared to make special sacrifices at the expense of its shareholders, staff and customers merely to cure the apparent internal problems of the German government coalition and help the Greens to regain lost votes. Unless the Federal Minister for the Environment rescinds his current cascade of conditions and requirements impeding the efforts on the part of operators to resume fuel transports, everything 'boils down to a court case'. That the French government, contrary to general expectations, had not given the green light this year for the construction of a first EPR plant was due primarily to internal political reasons, which had to be respected. It did not really matter whether that decision was taken in 2000 or 2001. The important thing was that the EPR was built at all, which was beyond any doubt. This is the gist of the statements by Dr. Otto Majewski, President of the German Atomic Forum and Chief Executive Officer of Bayernwerk AG, in the interview granted atw Editor-in-Chief Gerhard Kuebler and printed in this issue of 'Atomwirtschaft'. (orig.) [de

  9. 2005 DAtF winter meeting - pleading in favor of a sensible energy mix

    International Nuclear Information System (INIS)

    2005-01-01

    The year's Winter Meeting of Deutsches Atomforum, which was held under the general heading of 'Pleading in Favor of a Sensible Energy Mix', dealt with the large variety of aspects and perspectives of this important key topic, also with respect to the sustainability factors, environment, economy, and social aspects. Twelve contributions, or statements, by representatives from politics, industry, society, and research covered different aspects of a 'sensible energy mix'. A round of politicians debated the subject controversially. The meeting, which was attended by more than 250 participants, thus opened 2005 with an interesting presentation of present and future topics of the power supply debate. (orig.)

  10. Diverzifikace v analýze obalu dat ve financích

    OpenAIRE

    Macková, Simona

    2014-01-01

    Title: Diversification in Data Envelopment Analysis in Finance Author: Simona Macková Department: Department of Probability and Mathematical Statistics Supervisor: RNDr. Martin Branda, Ph.D., Department of Probability and Ma- thematical Statistics Abstract: This thesis deals with an extension of data envelopment analysis and its application in finance. This method enables to evaluate the efficiency of cho- sen production units based on several inputs and outputs. Administrative fees or risk m...

  11. McGregor-Mayweather: het gevecht dat alle mediarecords zal verbreken

    NARCIS (Netherlands)

    René Foolen

    De roddel domineert al maandenlang het nieuws en de echte vechtsportliefhebbers raken er maar niet over uitgesproken: een gevecht tussen MMA-vechter Conor McGregor en bokser Floyd Mayweather. Totaal ondenkbaar, want twee verschillende gevechtsdisciplines, maar tegelijkertijd ook heel logisch. Want

  12. ‘De duivel hale dat door en door in weelde en luiheid opgegroeide volk’

    Directory of Open Access Journals (Sweden)

    Coen van ’t Veer

    2016-02-01

    Full Text Available ‘The devil taketh those people who grew up in wealth and sloth’: Indianised Europeans, a danger to the colonial system From contemporary fiction on sea voyage appears a striking image. The ships that sailed between The Netherlands and Dutch East Indies, amidst 1850 and 1890, formed a micro colony: a compressed version of a colonial society. Practically, all components of a colonial community are represented on board. That includes the so-called backsliders: the Indianised Europeans. Analysis of eight novels on the sea voyages round Cape of Good Hope shows that Europeans that went native were represented in colonial discourse as a fundamental threat to colonial society, as they proved that the alleged superior Western civilization could be affected by supposed inferior Eastern cultures. For that encroaches upon the legitimacy of the colonial hegemony.

  13. De Sitter en Einstein. ‘Het lijkt mij dat Einstein hier een vergissing begaan heeft’

    Directory of Open Access Journals (Sweden)

    Jan Guichelaar

    2016-10-01

    Full Text Available De Sitter and EinsteinWillem de Sitter’s interest in gravity was based on his work on celestial mechanics, in particular on the four big moons of Jupiter. His work on cosmology was based on the general theory of relativity of Albert Einstein. De Sitter published in 1917, on request of Arthur Eddington to inform the English astronomers, a series of four articles in The Observatory and the Monthly Notices of the Royal Astronomical Society. Einstein developed his own cosmological models, containing mass. De Sitter found a different solution and described a universe without mass. Einstein could not accept De Sitter’s model and they ‘fought out’ two controversies in their correspondence. In theend Einstein had to confess De Sitter was mainly right in his criticisms. In 1932 Einstein and De Sitter published an article on a new model, the so-called Einstein-De Sitter Model of the universe. So, De Sitter was able to do fundamental work in classical celestial mechanics as well as in the new cosmological theories.

  14. Česká sociologie, empirický výzkum a zdroje dat

    Czech Academy of Sciences Publication Activity Database

    Čížek, Tomáš

    2009-01-01

    Roč. 7, č. 2 (2009), s. 27-32 ISSN 1214-438X R&D Projects: GA MŠk LA09010 Institutional research plan: CEZ:AV0Z70280505 Keywords : empirical sociological research * data archives * Czech Republic Subject RIV: AO - Sociology, Demography

  15. On the Large-Scaling Issues of Cloud-based Applications for Earth Science Dat

    Science.gov (United States)

    Hua, H.

    2016-12-01

    Next generation science data systems are needed to address the incoming flood of data from new missions such as NASA's SWOT and NISAR where its SAR data volumes and data throughput rates are order of magnitude larger than present day missions. Existing missions, such as OCO-2, may also require high turn-around time for processing different science scenarios where on-premise and even traditional HPC computing environments may not meet the high processing needs. Additionally, traditional means of procuring hardware on-premise are already limited due to facilities capacity constraints for these new missions. Experiences have shown that to embrace efficient cloud computing approaches for large-scale science data systems requires more than just moving existing code to cloud environments. At large cloud scales, we need to deal with scaling and cost issues. We present our experiences on deploying multiple instances of our hybrid-cloud computing science data system (HySDS) to support large-scale processing of Earth Science data products. We will explore optimization approaches to getting best performance out of hybrid-cloud computing as well as common issues that will arise when dealing with large-scale computing. Novel approaches were utilized to do processing on Amazon's spot market, which can potentially offer 75%-90% costs savings but with an unpredictable computing environment based on market forces.

  16. Přístupy k analýze textových dat v psychologii

    Czech Academy of Sciences Publication Activity Database

    Urbánek, Tomáš

    2007-01-01

    Roč. 51, č. 3 (2007), s. 290-300 ISSN 0009-062X R&D Projects: GA ČR(CZ) GA406/06/1577 Institutional research plan: CEZ:AV0Z70250504 Keywords : text analysis * content analysis * constructivism Subject RIV: AN - Psychology Impact factor: 0.133, year: 2007

  17. Získávání pravidel z dat

    Czech Academy of Sciences Publication Activity Database

    Holeňa, Martin

    2003-01-01

    Roč. 83, č. 2 (2003), s. 48-60 ISSN 0322-788X Institutional research plan: AV0Z1030915 Keywords : rule extraction from data * observational logic * method GUHA * rule extraction with artificial neural networks

  18. ESCo. How to deal with that?; ESCo. Hoe pak je dat aan?

    Energy Technology Data Exchange (ETDEWEB)

    Stooker, J.; Meerbach, R.A.C.; Seijsener, P.W. [Strukton Worksphere, Amsterdam (Netherlands)

    2013-01-15

    An Energy Service Company (ESCo) is a form of collaboration with high expectations. What does this new form of contract requires from the contractor and client? Where are the opportunities, what are the risks? And what does it take to make a success of an ESCo? [Dutch] Een Energy Service Company (ESCo) is een samenwerkingsvorm waar veel van wordt verwacht. Wat vraagt deze nieuwe contractvorm van opdrachtnemer en opdrachtgever? Waar liggen de kansen, wat zijn de risico's? En wat is er nodig om van een ESCo een succes te maken?.

  19. Agri-envrionmental indicators: recommendations for priority data collection and dat combination

    NARCIS (Netherlands)

    Velthof, G.L.

    2011-01-01

    This document is the result of the "DireDate project"'s tasks 4 and 5. The DireDate project focused on analysing the direct and indirect data needs linked to the farms, with the objective of setting up an efficient and sustainable data collection for agri-environmental indicators and policy

  20. 'Zo werkt dat hier niet' - Gevestigden en buitenstaanders in nieuwe sociale en ruimtelijke kade

    NARCIS (Netherlands)

    Hogenstijn, M.; van Middelkoop, D.P.

    2008-01-01

    Title: ‘That’s not how things work around here’ Subtitle: New social and spatial frameworks for established and outsiders Maarten Hogenstijn Daniël van Middelkoop Conflicts about the division of power between groups can be found anywhere. Struggles can be fought out between the original and new

  1. GM : Kun je dat eten? Gezondheidsrisico’s van gentech voedsel.

    NARCIS (Netherlands)

    Tiggelen, Bas van

    2004-01-01

    Genetische modificatie kan onbedoeld resulteren in producten met allergene eigenschappen,verhoogde toxiciteit, of verlies aan voedingswaarde. Dit zijn theoretische risico’s, over de hoogte waarvan weinig valt te zeggen wegens gebrek aan gegevens. Een deel van de mogelijke risico’s van GM-voedsel

  2. Waarom wij studenten niet vertellen dat de Griekse cultuur uit ‘Zwart Afrika’ komt

    NARCIS (Netherlands)

    Boter, G.J.; Flinterman, J.J.

    2016-01-01

    The present contribution is an offshoot of a public debate on Afrocentric criticisms of the teaching of Ancient History, held at the Vrije Universiteit Amsterdam in June 2015 (for a video recording of this event see https://www.youtube.com/watch?v=WMu5lncT8OU). We argue that the central tenets of

  3. Virtual reality in het onderwijs, hoe reëel is dat?

    NARCIS (Netherlands)

    Westera, Wim

    2017-01-01

    VR-technologie is onstuitbaar in opkomst. De prijzen dalen en de consumentenmarkt staat op doorbreken. Nu onderwijspioniers zich enthousiast op nieuwe VR-toepassingen voor leren en onderwijzen storten, rijst de vraag hoe we de educatieve potentie van VR moeten beoordelen: wordt het onderwijs beter,

  4. Archivace sociálněvědních dat: principy, technologie, standardy

    Czech Academy of Sciences Publication Activity Database

    Krejčí, Jindřich; Vávra, Martin; Čížek, Tomáš

    2011-01-01

    Roč. 61, č. 3 (2011), s. 245-272 ISSN 0004-0398 R&D Projects: GA MŠk LA09010 Institutional research plan: CEZ:AV0Z70280505 Keywords : archiving social science data * data management * Nesstar software Subject RIV: AO - Sociology, Demography

  5. Low seroprevalence of Leishmania infantum infection in cats from northern Portugal based on DAT and ELISA

    NARCIS (Netherlands)

    Cardoso, Luís; Lopes, Ana Patrícia; Sherry, Kate; Schallig, Henk; Solano-Gallego, Laia

    2010-01-01

    Cats have been considered playing a role in the epidemiology of leishmaniasis caused by Leishmania infantum, an endemic zoonosis in countries of the Mediterranean basin. The present study assessed the prevalence of antibodies to L. infantum in 316 domestic cats from northern Portugal, by means of

  6. Onheil dat voorbijgaat. Psalm 91 en de (oudoosterse) bedreiging door demonen

    NARCIS (Netherlands)

    Vreugdenhil, G.C.

    2013-01-01

    This study concerns the question how in biblical times people have dealt with the presence and reality of evil spirits and demons. In the modern western worldview the reality of evil spirits and demons seems to be something of the past. Science on the one hand deals with the natural world, which can

  7. Marketingové využití dat internetových obchodů

    OpenAIRE

    Přichystal, Jakub

    2014-01-01

    This thesis describes how internet shops can use customer data in order to create more effective marketing processes. Goal is to get overview of customer behaviour and preferences by analysing available data. Options for better marketing campaign targeting and customer segmentation are provided using results of this analysis. Theoretical part of thesis describes data sources, using these sources and metrics used for measuring marketing campaigns. Practical part consists of case study focused ...

  8. Association of ADHD, Tics, and Anxiety with Dopamine Transporter ("DAT1") Genotype in Autism Spectrum Disorder

    Science.gov (United States)

    Gadow, Kenneth D.; Roohi, Jasmin; DeVincent, Carla J.; Hatchwell, Eli

    2008-01-01

    Background: Autism spectrum disorder (ASD) is associated with high rates of psychiatric disturbance to include attention-deficit/hyperactivity disorder (ADHD), tic disorder, and anxiety disorders. The aim of the present study was to examine the association between a variable number tandem repeat (VNTR) functional polymorphism located in the…

  9. Evaluation of the therapeutic response to donepezil in patients with dat by 3DSRT

    International Nuclear Information System (INIS)

    Shigeaki Higashiyama; Terue Okamura; Koichi Koyama Yuichi Inoue; Joji kawabe; Kenji Torii; Susumu Shiomi; Hiroshi Hashimoto; Hisanori Akiyama; Kouki Inoue; Nobuo Kiriike

    2004-01-01

    Purpose: Alzheimer's disease (AD) is characterized by progressive impairment of memory and cognitive function associated with loss of presynaptic cholinergic function. It has recently been hypothesized that cholinergic agents such as cholinesterase inhibitors or cholinergic agonists may have the potential to improve these symptoms. One such compound is donepezil hydrochloride (Donepezil), which acts by blocking acetylcholinesterase and butyl cholinesterase, which hydoryze acetylcholine. In the diagnosis of AD, brain perfusion scintigraphy is an objective of visualization of brain perfusion. Up to the present, AD has been diagnosed objectively and quantitatively using brain perfusion single photon emission tomography (SPECT). In a quantitative evaluation of therapeutic response of Donepezil in AD, for comparison with regional cerebral blood flow (rCBF) in various lesions before and after treatment, uptake in various cerebral regions of interests (ROIs), such as the frontal lobes, temporo-occipital lobes, parietal lobes and cerebellar hemispheres, were used to be measured, The aim of this study was to investigate the accuratelity of therapeutic response of three-dimensional stereotaxic ROI template (3DSRT), fully automated ROI analysis software, which can objectively estimate rCBF in patients undergoing Donepezil therapy. We compare the effect of therapeutic response of three-dimensional stereotactic surface projections (3D-SSP). 3D-SSP is an image-processing and statistical program allowing pixel-by-pixel analysis of cerebral perfusion, provides a reliable and objective means of evaluation of severity of AD. On 3D-SSP images, we assessed the extent of abnormal region in each segment (rate of coordinates with a Z-value exceeding the.threshold value, of all coordinates within a segment) Methods: Twenty-one patients (15 females, 6 males;age range, 66-83 years old; mean age=69.4 years) diagnosed with AD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) were found not to hanve neurological abnormalities. Brain tumors and cerebrovascular disease were excluded by thourough laboratory screening and computed tomography (CT) and/or magnetic resonance (MR) scanning.Before and three months after starting donepezil, SPECT studies and the Alzheimer's Disease Assessment Scale Japan Cognitive Subscale Function Test (ADAS-J-COG) were performed as function tests. Seven hundred and forty MBq of Tc- 99m -Ethyl Cysteinate Dimer (ECD) was intravenously injected as a bolus within a few seconds. Passage of the tracer from the aortic arch to the brain was monitored in a 64x64 matrix format for 120 seconds at one-second intervals with the photo peak centered on 140 keV. The data were used for calculation of mean global cerebral blood flow. Then, the SPECT projection data were acquired once for 20 minutes from 5 minutes after i.v. injection of Tc- 99m -ECD, with a triple-head rotating gamma camera and fanbeam high-resolution collimators(GCA-9300, TOSHIBA) and the photo peak centered on 140 keV in 90 projections with 360-degree rotation (128 x 128 matrix format). Each scan was performed to obtain transverse images. 3DSSP and 3DSRT image analysis was performed on a personal computer equipped with a Windows 2000 operating system, in which the MS-DOS version of NEUROSTAT was implemented.On 3DSSP, we examined the cinguli gyrus bilaterally, and scored the change in Z value there. We scored 1 point when a significant decline in Z value in recognized, and if the decline in Z score was marked we scored 2 points. We compared total score before and after medication. On 3DSRT, we examined the rCBF values for the parietal lobe bilarterally, the temporo-occipital lobe, corpus callosum and cerebellar hemisphere. To evaluate therapeutic response by 3DSRT, we compared ratios (rCBF values of bilateral parietal lobe, temporo-occipital lobe, and corpus callosum / cerebellar hemisphere) before and after medical treatment. We judged the treatment was effective in the case that improvement of rCBF was found in more than four of six legions, and we judged that the treatment was ineffective against the case except them. Results: In 10 patients who had recognitive improvement on ADAS-JCOG, 8 patients exhibited improvement in 3DSSSP and 7 patientsin 3DSRT. In other 12 patients who did not have recognitive improvement on ADAS-JCOG, 11 patients did not exhibit improvement on 3DSSP and 3DSRT. Conclusions: Evaluation of therapeutic response by 3DSRT was extremely precise, and the accuracy of 3DSRT with 3DSSP was demonstarated. (authors)

  10. Implications of Common Core State Standards on the Social Studies

    Science.gov (United States)

    Kenna, Joshua L.; Russell, William B., III.

    2014-01-01

    Social studies teachers have often been on the outside looking in during much of the era billed as the standards-based educational reform (SBER), but with the adoption and implementation of the Common Core State Standards (CCSS), social studies teachers seem to have been invited back inside. Yet, how will the standards impact social studies…

  11. RETARDANTY HOŘENÍ, JEJICH POUŽITÍ A VLIV NA ŽIVOTNÍ PROSTŘEDÍ

    Czech Academy of Sciences Publication Activity Database

    Petrová, Šárka; Soudek, Petr; Vaněk, Tomáš

    2015-01-01

    Roč. 109, č. 9 (2015), s. 679-686 ISSN 0009-2770 R&D Projects: GA MŠk(CZ) LD13028 Institutional support: RVO:61389030 Keywords : pollution * bioaccumulation Subject RIV: DJ - Water Pollution ; Quality Impact factor: 0.279, year: 2015 http://www.chemicke-listy.cz/docs/full/2015_09_679-686.pdf

  12. Big Data, jejich skladování a možnosti využití

    OpenAIRE

    Macek, Jáchym

    2013-01-01

    The content of this bachelor's thesis is to analyze work with data especially with large-volume unstructured data, thus Big Data. The thesis is retrieval and contents informational survey based on questionnaires and interviews. The aim is to evaluate and approximate Big Data theme, their storage, tools for their management and opportunities of its exploitation to the reader from technological and business point of view. The objective for the practical part is a survey. The thesis is divided i...

  13. Nádorové markery a jejich využití v klinické praxi

    Czech Academy of Sciences Publication Activity Database

    Machová, Iva; Brázdová, A.; Fusek, M.; Zídková, J.

    2012-01-01

    Roč. 106, č. 1 (2012), s. 16-19 ISSN 0009-2770 Grant - others:GA AV ČR(CZ) IAA600110902 Program:IA Institutional research plan: CEZ:AV0Z40550506 Keywords : prostate -specific antigen * P53 * cancer * population Subject RIV: CC - Organic Chemistry Impact factor: 0.453, year: 2012

  14. Standardy likvidity podle BASEL III a jejich dopad na vybrané banky ČR

    OpenAIRE

    Plíva, Rostislav

    2014-01-01

    Subject of this dissertation thesis is the readiness of selected Czech banks and one cooperative lending institution to implementation of BASEL III capital requirements. Analysis is concentrated to current state of BASEL II and BASEL III in field of liquidity. For a purpose of comparison the indicator of Liquidity Coverage Ratio required by BASEL III is calculated and, when necessary, theoretically modeled. Institutions are analyzed whether they are ready and what measures should be implement...

  15. Obchodní vztahy ČR s Indonézií a jejich perspektivy

    OpenAIRE

    Pertl, Nikola

    2010-01-01

    This bachelor thesis analyses chronological development of business relations between the Czech Republic or Czechoslovakia and Indonesia, with focus on the period after World War I. The work should also inform about current state, opportunities and threats for the Czech trade with the fourth most populous country of the world. Last but not least, this thesis deals with the future prospects of the respective business relations, mainly based on primary research.

  16. Organické odpady a průmyslové technologie jejich koprocesingu s uhlím

    Czech Academy of Sciences Publication Activity Database

    Kříž, Vlastimil; Buchtele, Jaroslav

    2005-01-01

    Roč. 10, 1 /mim.č./ (2005), s. 67-71 ISSN 1335-1788. [Mezinárodná konferencia Mineralurgia a environmentálne technológie /3./. Herlany, 20.09.2005-22.09.2005] Institutional research plan: CEZ:AV0Z30460519 Keywords : organic waste s * coal * co-processing coal/ waste s Subject RIV: DM - Solid Waste and Recycling http://actamont.tuke.sk

  17. Organizování, plánování a jejich návaznost v podniku

    OpenAIRE

    EIGNER, Martin

    2011-01-01

    The main aim of my work is to evaluate the level of organizing, planning and their mutual effectiveness in Měšťanský pivovar Strakonice. By defining these concepts, performance analysis and assessment of coherence in the enterprise.

  18. Explanační principy ve studiu kolektivní paměti: Kultura, kognice a jejich situovanost

    Directory of Open Access Journals (Sweden)

    Tomáš Karger

    2017-12-01

    Full Text Available Research addressing collective memory in the Czech context is predominantly based on the constructivist approach laid out by Maurice Halbwachs. This approach can be characterized by an assumption of omnipresent existence of stable structures of meaning with which action is explained. In the existing literature, we can also find alternative approaches based on findings of the cognitive sciences. These approaches can be characterized by searching for neurophysiological invariants which determine the diffusion of cultural representations. With respect to this state of the research field, the aim of this text is twofold. First, to demonstrate that the assumptions highlighting supra-individual semantic structures introduced by the Halbwachsian tradition lead to premature closure of explanation, without taking into account the question of diffusion of semantic structures. Second, to show that the focus on cognitive phenomena (taking into account the question of diffusion of semantic structures does not have to lead to acceptance of reductionist premises. As a result, this study attempts to suggest an approach which would be able to study collective memory without reliance on supra-individual entities on the one hand and on reductionist assumptions on the other. It seems that the approach of Situational Analysis fits those criteria well and therefore it is introduced in the concluding parts of the text.

  19. „Malá slova“ a jejich podíl na stylu mluvených projevů

    Czech Academy of Sciences Publication Activity Database

    Hoffmannová, Jana

    2017-01-01

    Roč. 26, č. 1 (2017), s. 155-171 ISSN 1230-2287 R&D Projects: GA ČR GA15-01116S Institutional support: RVO:68378092 Keywords : spoken Czech * syntax * conversation * turn * parts of speech * particles * connectives * pronouns * interjections * discourse markers Subject RIV: AI - Linguistics OBOR OECD: Linguistics

  20. Analýza marketingových aktivit a jejich vliv na děti

    OpenAIRE

    Kaštylová, Jana

    2011-01-01

    This work deals with marketing and its impact on children, focusing on advertising. The aim is to identify the advantages and disadvantages of different forms of advertising, which one is the most used with targeting on children, how children perceive advertising and how they are protected from advertising by the law. In the second part, there is a research and an analysis of perception of advertising by children in general and perception of marketing of Jojo club (Nestlé) and its impact on c...

  1. Nadnárodní společnosti a jejich role ve světové ekonomice

    OpenAIRE

    VÁŇOVÁ, Ivana

    2012-01-01

    Bachelor thesis gives general characteristics of multinational corporations. The thesis is divided into two major parts. The first part familiarizes the reader with definitions and classifications of multinational corporations and their strategies of entry to foreign markets. Theoretical part concludes with a chapter about globalization, a phenomenon, which is closely associated with development and influence of multinational corporations. Practical part focuses on two multinational corporati...

  2. Strukturované produkty na bázi komodit a jejich ekonomický význam

    Directory of Open Access Journals (Sweden)

    Oldřich Rejnuš

    2014-03-01

    Full Text Available Purpose of the article: The article deals with issues of contemporary interconnecting of commodities market with financial investment instrument markets, with special regards to the influence of contemporary changes in commodities trading and creating individual sorts of structured products based on commodities. Considering the fact that mutual interconnections between commodities and financial investment instruments are not random, where, beside its theoretical interestingness, they have their insignificant economic importance, the aim of the article is to analyse contemporary utilization of individual sorts of commodity structured products both from the point of view of theoretical nature and, before all, their economic importance. In connection with it, reasons of contemporary spreading of synthetic financial derivative instruments derived from commodities, commodity stock exchange indexes or individually constructed, so called commodity baskets, are explored. And last but not least, it deals with a question whether this is just a temporary situation or continuation of the phenomenon can be supposed. Methodology/methods: The article deals with system analysis of relations between commodity underlying assets and individual sorts of structured products and analysis contemporary changes in ways how commodities are traded in stock exchanges; it is focused on how they influence creating structured products. Scientific aim: The aim of the research is to specify both positive and negative aspects of mutual interconnection of commodity instruments with individual structured products and to predict future development in this field with regards to possible influences on world economy. Findings: The article explains contemporary changes in the way how commodities are traded at world stock exchanges and it specifies both positive and negative influences of these changes on world economy. Conclusions: Based on accomplished analysis of connections between underlying commodity assets and individual sorts of structured products as well as contemporary changes of ways of commodities trading at stock exchange, internationally coordinated state regulation is recommended as well as stricter supervision of institutions working in this area.

  3. Příprava nesymetricky substituovaných bipyridinů a jejich využití

    Czech Academy of Sciences Publication Activity Database

    Hrdina, R.; Kotora, Martin

    2005-01-01

    Roč. 99, č. 11 (2005), s. 844 ISSN 0009-2770. [Pokroky v organické, bioorganické a farmaceutické chemii /40./. 18.11.2005-20.11.2005, Nymburk] R&D Projects: GA ČR(CZ) GA203/05/0102 Institutional research plan: CEZ:AV0Z40550506 Keywords : bipyridine * cyclotrimerization * asymmetric synthesis Subject RIV: CC - Organic Chemistry

  4. Analýza licencí typu open source a jejich použití v praxi

    OpenAIRE

    Neumann, Martin

    2010-01-01

    The aim of this bachelor thesis is to analyse the most commonly used open source/free software licenses. After brief introduction to the history and defining related terms, there is a classification of licenses by the method of distribution. An analysis of the most common licenses is brought in, followed by presentation of the main points of licensing conditions in the Czech language. The main purpose of this work is to create a transparent methodology for selecting the proper licenses accord...

  5. Aktivace makrofágu antigeny potravy: glutenem, gliadinem a jejich enzymatickými štěpy

    Czech Academy of Sciences Publication Activity Database

    Tučková, Ludmila; Žídek, Z.; Flegelová, Z.; Novotná, Jana; Novák, Petr; Jelínková, Ludmila; Jamison, T.; Tlaskalová, Helena

    2000-01-01

    Roč. 2, Suppl 2 (2000), s. 11 ISSN 1212-687X. [Congress of the Czech and Slovak Immunologists /9./. 25.10.2000-28.10.2000, Liberec] Institutional research plan: CEZ:AV0Z5020903 Subject RIV: EC - Immunology

  6. Chemicky aktivované a roubované substráty a jejich analýza

    Czech Academy of Sciences Publication Activity Database

    Benkocká, M.; Knapová, T.; Braborec, Jakub; Matoušek, J.; Černá, H.; Londesborough, Michael Geoffrey Stephen; Švorčík, V.; Kolská, Z.

    2015-01-01

    Roč. 109, č. 12 (2015), s. 960-964 ISSN 0009-2770 Institutional support: RVO:61388980 Keywords : surface activation * piranha solution * surface grafting Subject RIV: JJ - Other Materials Impact factor: 0.279, year: 2015

  7. Antimikrobiální peptidy: Vztah mezi jejich strukturou a antibakteriální aktivitou

    Czech Academy of Sciences Publication Activity Database

    Doležílková, Ivana; Macková, Martina; Macek, Tomáš

    2011-01-01

    Roč. 105, č. 5 (2011), s. 346-355 ISSN 0009-2770 Grant - others:GA ČR(CZ) GA522/09/1693; GA ČR(CZ) GD305/09/H008 Program:GA; GD Institutional research plan: CEZ:AV0Z40550506 Keywords : antimicrobial activity * antimicrobial peptides * escherichia coli Subject RIV: CC - Organic Chemistry Impact factor: 0.529, year: 2011

  8. Akordické paralelismy a jejich funkce v Ostrčilově opeře Poupě

    Czech Academy of Sciences Publication Activity Database

    Zapletal, Miloš

    2015-01-01

    Roč. 52, 3/4 (2015), s. 365-394 ISSN 0018-7003 Institutional support: RVO:68378076 Keywords : chordal parallelism * parallel triads * first-inversion chord * Ostrčil * Poupě * The Bud * Czech opera * musical hermeneutics * musical semiotics * verismo Subject RIV: AL - Art, Architecture, Cultural Heritage

  9. Felix Vodička: Úkoly literární historie a jejich zdroj

    Czech Academy of Sciences Publication Activity Database

    Kubíček, Tomáš

    2010-01-01

    Roč. 92, 1/2 (2010), s. 85-94 ISSN 0862-8459. [100 let generace prvních žáků PLK. Praha, 09.02.2009-09.02.2009] R&D Projects: GA ČR GA405/07/0077 Institutional research plan: CEZ:AV0Z90560517 Keywords : history of literature * Vodička, Felix * structuralism Subject RIV: AJ - Letters, Mass-media, Audiovision

  10. Trendy v elektronické diachronní lexikografii a jejich využitelnost ve slavistice

    Czech Academy of Sciences Publication Activity Database

    Knoll, Vladislav

    2017-01-01

    Roč. 86, 2-3 (2017), s. 301-334 ISSN 0037-6736 R&D Projects: GA MK DG16P02H024 Keywords : diachronic lexicography * electronic lexicography * Slavonic lexicography Subject RIV: AI - Linguistics OBOR OECD: General language studies

  11. Metody pro redukci dimenze v mnohorozměrné statistice a jejich výpočet

    Czech Academy of Sciences Publication Activity Database

    Kalina, Jan; Duintjer Tebbens, Jurjen

    2014-01-01

    Roč. 25, č. 1 (2014), s. 13-29 ISSN 1210-8022 R&D Projects: GA ČR GA13-06684S Institutional support: RVO:67985807 Keywords : redukce dimense * spektrální rozklad * numerická stabilita Subject RIV: BA - General Mathematics http://www.statspol.cz/cs/wp-content/uploads/2014/4/IB_1_2014.pdf

  12. Životní spokojenost adolescentů ve vztahu k jejich hodnotovým orientacím

    Czech Academy of Sciences Publication Activity Database

    Blížkovská, J.; Klimusová, Helena; Jelínek, Martin; Blatný, Marek

    Suppl., č. 19 (2004), s. 21-22 ISSN 0887-0446 Institutional research plan: CEZ:AV0Z7025918 Keywords : Life satisfaction * adolescence * values Subject RIV: AN - Psychology Impact factor: 1.683, year: 2004

  13. Mezinárodní konglomeráty luxusního zboží a jejich specifika

    OpenAIRE

    Jandová, Denisa

    2015-01-01

    The main theme of this thesis identifies the specifics of international luxury good conglomerates and their functioning. The aim of this work is to clearly map and describe the conglomerates' functioning, their brand's position, and the positive and the negative effects of their presence. The content of the thesis includes the definition of luxury and luxury goods, and also a brief overview of the worldwide trends and consumer preferences in the luxury segment. The following part contains an ...

  14. Paralelní robotické struktury a moderní metody jejich řízení

    Czech Academy of Sciences Publication Activity Database

    Belda, Květoslav

    2009-01-01

    Roč. 52, č. 5 (2009), s. 296-300 ISSN 0005-125X Institutional research plan: CEZ:AV0Z10750506 Keywords : Parallel robotic structures * industrial robotic s * predictive control * real-time control Subject RIV: BC - Control Systems Theory http://library.utia.cas.cz/separaty/historie/belda-0325559.pdf

  15. 3rd DAtF-seminar on the development of potential for young scientists and engineers in nuclear technology

    International Nuclear Information System (INIS)

    Gassner, H.

    2003-01-01

    The 3 rd seminar organized by the Deutsches Atomforum e.V. for young nuclear scientists and engineers seeking to realize their potential was about 'Communication - Key to Acceptance'. The topic was presented in contributions outlining the scientific viewpoint and in results of practical everyday experience. The young participants from all areas of the nuclear industry were sensitized to the problem areas under discussion, which were then debated in more detail. Reference was made to the importance of continuous communication with all participants. The seminar offered valuable suggestions for working with the media and the public, but also for handling information in one's daily work. (orig.)

  16. Určení druhové skladby lesa z družicových dat

    OpenAIRE

    Launer, Michal

    2017-01-01

    Forest species determination from satellite data Abstract Examining the species composition of forests from satellite imagery is constantly evolving. The new ways of exploring forests from the satellites make it easier for foresters to maintain a more accurate and up-to-date overview of the state of forests. In this work, the research was made on the forests in the cadastral territories of Osvětimany and Buchlovice in the Chřiby Mountains in the Czech Republic. In this work, data from the Lan...

  17. Smart grid: rendement voor iedereen : Wat maakt dat mensen mee willen doen aan een smart grid pilot?

    NARCIS (Netherlands)

    Milovanovic, Marko

    2013-01-01

    We hebben in dit onderzoek pilotdeelnemers en niet-deelnemers gevraagd welke aspecten van smart grid systemen ze belangrijk vinden. Beide groepen mensen noemden het volgende rijtje prioriteiten: financiële besparing, functionaliteit, milieuvriendelijkheid, persoonlijk comfort, lokale energie. Dit

  18. Het stereotype beeld van een dakloze is dat hij een man is. Opvang van gezinnen na huisuitzetting

    NARCIS (Netherlands)

    dr Lia van Doorn; W. de Graaf; Catelijne Akkermans; dr Raymond Kloppenburg

    2008-01-01

    Voor u ligt een tussenrapportage van een onderzoek naar de opvang van gezinnen na huisuitzetting. De aanleiding hiervoor zijn berichten in de media die lijken te wijzen op een verontrustende toename van het aantal dakloze gezinnen. De staatssecretaris van VWS stelt in haar antwoord op Kamervragen

  19. Pokročilý editor VHDL souborů

    OpenAIRE

    Kliment, Vojtěch

    2012-01-01

    Tato bakálářská práce se zabývá vývojem aplikace, která umožňuje návrháři číslicových obvodů snadněji vkládat a propojovat jednotlivé komponenty VHDL entity. Práce vysvětluje základní principy jazyka VHDL a způsob, jakým se v jazyce VHDL číslicové systémy popisují. Dále jde zde nastíněna problematika syntetizovatelných šablon a jsou vysvětleny důvody jejich používání. V dalších částech práce je popsán návrh a způsob implementace editoru, který poskytuje uživateli možnost snadnější práce na n...

  20. Medical Image Data Compression

    OpenAIRE

    Šebek, Jiří

    2012-01-01

    Práce zkoumá, jak se projeví účinek různých komprimačních algoritmů na obrazových datech v medicíně. Snaží se najít algoritmus nebo skupinu algoritmů, které budou mít největší kompresní účinek. Kromě použití klasických algoritmů je snaha využít vlastností medicínských dat (tj. že obsahují hodně podobných obrazových bodů) pro jejich lepší kompresi. Ověříme si účinnek delta kódování na výsledný kompresní poměr a na závěr uvedeme naši nejlepší nalezenou metodu. The efficiency of various compr...

  1. Sociokulturní diverzita organizací ve vzdělávání

    Directory of Open Access Journals (Sweden)

    Alena Felcmanová

    2018-04-01

    Full Text Available „Jiné instituce, jiná pravidla, jiný vztah“ – tak by se dal shrnout často opakovaný motiv rozhovorů s pracovníky různých institucí – škol, OSPOD, NNO – vzhledem k jejich spolupráci během zavádění tzv. inkluzivního vzdělávání. Podobně jako v dalších zemích i v ČR probíhá v reakci na sociokulturní diverzitu ve společnosti rozvoj tzv. inkluzivního vzdělávání. Změna vzdělávací politiky přináší prostor pro redefinici rolí aktérů, kteří se angažují především v oblasti práce s dětmi se sociálním znevýhodněním, a otevírá nové pole pro spolupráci mezi nimi. Ve studii jsou analyzovány kultury organizací, vzájemné recepce skupin aktérů a vymezování jejich rolí a vzájemných očekávání vzhledem k jejich spolupráci. Data byla zpracována skrze analýzu aktérů a kvalitativní rozhovory s aktéry NNO, škol a OSPOD ve dvou českých městech. Z nasbíraných dat vyplynulo, že kultura organizací (Cook & Yanow, 1993; Schein, 1990, má velký vliv na vztah s klienty i možnosti spolupráce s ostatními aktéry, nicméně je jen málo reflektována Cestou může být jasná komunikace hodnot i extenzivní normativní profesionalismus (Klaassen & Maslovaty, 2010. Diskuze o rolích aktérů ve vzdělávání je tedy zároveň diskuzí o identitě, diverzitě a kultuře organizací.

  2. Globalizační procesy v Indii a jejich vliv na psychiku a chování lidí

    OpenAIRE

    Zhitina, Anna

    2013-01-01

    This thesis deals with globalization process in India and its impact on people's mind and behavior. Also, this work describes the attitudes and emotions of people who are affected by this phenomenon, explains how principles of globalization were applied in the country, both in society and in the Indian national economics, particularly in the food industry, analyzes the role of mass media in globalization process and finally, clarifies specific problems which multinational companies faced when...

  3. Řešení diferenčních rovnic a jejich vztah s transformací Z

    OpenAIRE

    Klimek, Jaroslav

    2011-01-01

    Tato disertační práce pojednává o řešení diferenčních rovnic a soustřeďuje se na metodu řešení diferenčních rovnic pomocí vlastních vektorů. V první části jsou v přehledu nejdříve uvedeny základní pojmy diferenčních rovnic jako dynamika diferenčních rovnic, lineární diferenční rovnice prvního a vyššího řádu. Dále jsou v této kapitole připomenuty i systémy diferenčních rovnic včetně fundamentální matice a popisu obecného řešení. Nakonec je připomenuta metoda řešení diferenčních rovnic variací ...

  4. Klíčové ukazatele výkonnosti (KPI) a jejich vazba na vrcholový ukazatel EVA

    OpenAIRE

    Hanzlík, Kamil

    2008-01-01

    This thesis is concerned with a discussion of advantages, disadvantages and potencial areas of usage of the Economic Value Added (EVA) as a measure of value based management. The coherency of EVA with key performance indicators as a tool of effective management is also analysed. Mentioned are also several alternative concepts. This thesis further analyses practical application of key performance indicators in mobile telecommunication company T-Mobile and evaluates the implemented concept of E...

  5. Osečtí cisterciáci doby barokní. Malachias Welcker a Anton Edelmann a jejich rukopisné „kroniky“

    Czech Academy of Sciences Publication Activity Database

    Wolf, Jiří

    2014-01-01

    Roč. 29, č. 2 (2014), s. 197-219 ISSN 0231-7494 R&D Projects: GA ČR(CZ) GA14-05167S Institutional support: RVO:67985963 Keywords : Cistercian order * Baroque historiography * the space * the body * Malachias Welcker * Anton Edelmann Subject RIV: AB - History

  6. Etika ve zdravotnictví a sociální práci - komparace principů a jejich aplikací

    OpenAIRE

    ČADOVÁ, Lenka

    2013-01-01

    Ability and willingness to act ethically is the basis of the quality of the service in helping professions. This thesis deals with the fact which ethical principles are considered to be the most important in work of health care professionals and social workers of the civic association Prevent. In the theoretical part it is dealt with professional ethics, specifics of ethics in health care and social work, about the ethical codes of health and social workers and ethical principles of these pro...

  7. Role občanského sektoru při realizaci inovativních projektů a jejich přínos

    OpenAIRE

    Pešatová, Veronika

    2015-01-01

    The thesis addresses subject of innovative projects of NGOs in the field of parental support to return to the labour market after maternity leave. The main purpose of the thesis is to deliver a report about the role of the NGO in the process of implementation of innovative projects by using case studies. The objective of the thesis is to identify outcomes and level of innovation of these projects on the basis of testimonies of active participants. The theoretical part of the thesis describes ...

  8. Pohřebiště Pražského hradu a možnosti jejich sociální interpretace

    Czech Academy of Sciences Publication Activity Database

    Frolík, Jan; Kaupová, S.

    2016-01-01

    Roč. 41, č. 1 (2016), s. 101-122 ISSN 0231-5823 R&D Projects: GA ČR GB14-36938G Institutional support: RVO:67985912 Keywords : burial ground * Prague Castle * Early Middle Ages * elite * stable isotopes * social differentiation * nutrition Subject RIV: AC - Archeology, Anthropology, Ethnology

  9. Středoevropské bezlesí v čase a prostoru. II. Doklady z minulosti a jejich výpověď

    Czech Academy of Sciences Publication Activity Database

    Ložek, Vojen

    2004-01-01

    Roč. 59, č. 2 (2004), s. 38-43 ISSN 1210-258X Institutional research plan: CEZ:AV0Z3013912 Keywords : Woodland * Open Country * Human Impact Subject RIV: DB - Geology ; Mineralogy http://www.casopis.ochranaprirody.cz/res/data/003/000463.pdf

  10. Federalistické principy Lisabonské smlouvy a jejich vliv na suverenitu členských států EU.

    OpenAIRE

    VESELÝ, Lukáš

    2008-01-01

    This thesis analyses Treaty of Lisbon in order to reveal federalist principles contained in this new reformative treaty. This will enable to infer the impact on the sovereignty of the EU member states in case the Treaty of Lisbon would be ratified.

  11. Syntéza amfifilních helicenů a jejich samoskladba v tenkých vrstvách

    Czech Academy of Sciences Publication Activity Database

    Holec, Jan; Rybáček, Jiří; Janoušek, Jiří; Bednárová, Lucie; Stará, Irena G.; Starý, Ivo

    2016-01-01

    Roč. 14, č. 2 (2016), s. 65-66 ISSN 2336-7202. [Mezioborové setkání mladých biologů, biochemiků a chemiků /16./. 10.05.2016-13.05.2016, Milovy] R&D Projects: GA ČR(CZ) GA16-08327S Institutional support: RVO:61388963 Keywords : helicenes * Langmuir-Blodgett thin films * molecular electronics Subject RIV: CC - Organic Chemistry

  12. Liposomy, jejich charakterizace, příprava a inkorporace do nanovlákenných nosičů

    Czech Academy of Sciences Publication Activity Database

    Vocetková, Karolína; Míčková, Andrea; Jarošíková, T.; Rosina, J.; Handl, M.; Amler, Evžen

    2014-01-01

    Roč. 2, č. 44 (2014), s. 11-17 ISSN 0301-5491 Grant - others:GA UK(CZ) 424213; GA UK(CZ) 545313; GA UK(CZ) 270513; GA MŠk(CZ) CZ.1.07/2.3.00/20.0092; GA MZd(CZ) NT12156 Institutional support: RVO:68378041 Keywords : iposome * controlled drug delivery * nanofibers Subject RIV: FP - Other Medical Disciplines

  13. Pomístní jména, jejich stabilita a vztah k historii krajiny. Na příkladu Bernartic u Milevska

    Czech Academy of Sciences Publication Activity Database

    Dohnal, Martin

    2016-01-01

    Roč. 42, č. 1 (2016), s. 43-82 ISSN 0323-0988 Institutional support: RVO:68378076 Keywords : local names * historical landscape * Early Modern history * 1600-2000 * Bernartice (district of Písek) Subject RIV: AC - Archeology, Anthropology, Ethnology

  14. Trendy marketingu na sociálních sítích a jejich využití ve sportu

    OpenAIRE

    Kropáček, Josef

    2017-01-01

    Topic: Trends marketing on social networks and their use in sport Objectives: The main objective is Diploma thesis is a study of current trends in marketing on social networks toward use in sports. Methods: In thesis were analyzed current trends in marketing on social networks with application to sport and used to analyze methods of monitoring, observation. Further, it was in sports topic also used semi structured interview with the PR managers of sports organizations and a questionnaire surv...

  15. Vysoké kotvení v chodbách pro dvojí použití a jejich monitoring

    Czech Academy of Sciences Publication Activity Database

    Kukutsch, Radovan; Souček, Kamil; Koníček, Petr; Ptáček, Jiří

    2012-01-01

    Roč. 19, říjen (2012), s. 24-28 ISSN 1210-7697. [Hornická Příbram ve vědě a technice 2012 /51./. Příbram, 16.10.2012-18.10.2012] R&D Projects: GA MŠk ED2.1.00/03.0082; GA MV VG20102014034 Institutional support: RVO:68145535 Keywords : high anchoring * dual use corridors * cable bolt loading Subject RIV: DH - Mining, incl. Coal Mining

  16. Jak sbírat údaje o migrantech a jejich rodinách: možnosti, výhody a limity

    Czech Academy of Sciences Publication Activity Database

    Uherek, Zdeněk; Bareš, P.; Beranská, Veronika; Brouček, Stanislav; Horáková, M.; Kissová, Blanka; Kubát, J.; Schebelle, D.

    2014-01-01

    Roč. 3, č. 1 (2014), s. 52-56 ISSN 1805-2886 R&D Projects: GA TA ČR(CZ) TD010220 Institutional support: RVO:68378076 Keywords : migration * foreigners * Czech Republic * methodology Subject RIV: AC - Archeology, Anthropology, Ethnology

  17. Současné sociální změny, jejich důsledky a syndrom vyhoření

    Czech Academy of Sciences Publication Activity Database

    Kebza, V.; Šolcová, Iva

    2013-01-01

    Roč. 57, č. 4 (2013), s. 329-341 ISSN 0009-062X Institutional support: RVO:68081740 Keywords : burnout syndrome * unemployment * engagement * organizational civility Subject RIV: AN - Psychology Impact factor: 0.292, year: 2013

  18. Místní klimatické zóny a jejich význam ve městech České republiky

    Czech Academy of Sciences Publication Activity Database

    Lehnert, M.; Geletič, Jan

    2017-01-01

    Roč. 20, č. 2 (2017), s. 9-16 ISSN 1212-0855 Institutional support: RVO:86652079 Keywords : local climate zones * air temperature * urban heat island Subject RIV: DG - Athmosphere Sciences, Meteorology OBOR OECD: Climatic research http://www.uur.cz/images/5-publikacni-cinnost-a-knihovna/casopis/2017/2017-02/04-mistni.pdf

  19. Osobnostní charakteristiky sourozenců dětí s postižením a jejich vývoj

    OpenAIRE

    Kolečková, Tereza

    2017-01-01

    The topics of this bachelor thesis are: personal characteristics, sibling relationships and cognitive, psychosocial and emotional development of siblings of disabled children. The aforementioned disabled children are primarily children with mental retardation and children within the autistic spectrum. This thesis focuses on the reaction of siblings and parents to the diagnosis of the disabled child and its effect in the quality of the family life. A number of studies have shown that siblings ...

  20. Postavy, novinářské texty a jejich emblémy (v psaní Terezy Boučkové)

    Czech Academy of Sciences Publication Activity Database

    Kudlová, Klára

    3 /20/, č. 2 (2011), s. 96-111 ISSN 1337-9275 Institutional research plan: CEZ:AV0Z90560517 Keywords : Czech literature * "authentic" fiction * emblem * Boučková, Tereza * palimpsest * hypertextual discourse Subject RIV: AJ - Letters, Mass-media, Audiovision

  1. Přesnost regionálních stereotypů a mechanismy jejich vytváření

    Czech Academy of Sciences Publication Activity Database

    Hřebíčková, Martina

    2013-01-01

    Roč. 57, č. 3 (2013), s. 230-245 ISSN 0009-062X R&D Projects: GA ČR GA13-25656S Institutional support: RVO:68081740 Keywords : regional stereotypes * accuracy * five-factor model of personality Subject RIV: AN - Psychology Impact factor: 0.292, year: 2013

  2. Regionální značky a jejich úloha na spotřebitelském trhu potravin

    OpenAIRE

    ŽÁK, Martin

    2017-01-01

    The thesis deals with regional brands and their role in the consumer food market, where the theoretical part to the introduction explains the basic concepts related to consumer behaviour and respect for regional consumer brands. The following is an explanation of concepts such as food quality, safety and support local producers and what is imaginable about concepts of brand and regional brand. The theoretical part is further given literary review of selected regional brands in South Bohemia, ...

  3. PERSPEKTIVY FIREM OLIGOPOLNÍHO LEMU V PODMÍNKÁCH EKONOMICKY SE SJEDNOCUJÍCÍ EVROPY A JEJICH VLIV NA MAKROEKONOMICKÉ VELIČINY

    Directory of Open Access Journals (Sweden)

    Jiří Kraft

    2013-10-01

    Full Text Available The Czech Republic entranced into the European Union in 2004 to bridge over a disparity collocating to necessity of a mass production in connection with using new technology, which do not pay at a small production quantity – on the one hand, on the other hand attached a low level of the domestic purchase power as a result no high incomes of inhabitants in the Czech Republic, as well as a result small number of customers, and more over, the monopolization of the Czech market bringing quite a number of negatives was solved. But, one question arises more: haw small and medium enterprises influence on the new reality in the Czech Republic. It is a fundamental question, because just the small and medium enterprises employ the most percent of inhabitants, they are a resource of essential innovations, and their share in Czech foreign trade increases markedly. Their increasing share in GDP evidences a dependence of national economy, respectively EU economy just on these subjects of the supply side. Small and medium enterprises present so called “oligopoly hem” in the framework of imperfect competition reality, which an important position in the EU integrated market, where monopolies by competition “powdered” transformed in oligopolies with a dominant firm. An oligopoly price is for customer more favourable than a monopoly price, as well a production quantity is higher. More over, an interest in decreasing costs rises in the oligopoly hem. The costs are too high in contrast with a dominant firm. Simultaneously, other way to increasing profit of an oligopoly hem – analogically as for firms in perfect competition – does not exist. The cost decrease in firms of the oligopoly hem presses the dominant firm to decrease its price. This fact decreases an inflation rate in macroeconomic connection, and more, the share of the dominant firm on the market decreases. It leads to decrease of its production costs, which leads to increasing competitive strength. Then, a balance of foreign trade is influenced too. The comparison of the Czech magic tetragons from 2003 (i.e. in the year before the entrance into the EU, 2004 (i.e. the entrance year, and 2006 (i.e. after the entrance but no immediately argues a positive evaluation of the Czech Republic entrance into the EU. The surface of Czech magic tetragon is enough large in comparison with the EU tetragon surface, and at the same time, it is increasing at comparison of the Czech economy in 2004 and 2006. However, this fact is not sufficient as an evidence of a success development for economic theory. The tetragon surface has to not only grow up, but the growth has to be equable too. And it gets on in the Czech economy (except minimal changes in the inflation rate, but this stand can be considered as optimal too. A macroeconomic reality influences a microeconomic reality, which determines macroeconomic outcomes consequently. The considered microeconomic reality was the supply side – firms. The market structure in the Czech Republic is an imperfect competition evidently, and variation of forms is typical just for imperfect competition. Without the entrance of the Czech Republic into the EU, respectively without liquidation of custom and other trade restrictions, would be strengthen the monopoly form of imperfect competition on the Czech market, which leads to abuse of producer dominant position very often, namely by monopoly price, or by stagnation in the framework no interest of monopoly in technical economic progress. The entrance of the Czech Republic into the EU influences this reality positively. It gives rise – of course along with other facts – to substitution of the monopoly form into the oligopoly form of imperfect competition.

  4. Problematika slevových portálů a jejich spolupráce s poskytovateli

    OpenAIRE

    Čeladníková, Tereza

    2011-01-01

    My bachelor essay discusses the topic of deal-of-the-day websites. In the foreword the key words as a deal-of-the-day website, sale-search engine, affiliate program and its connectivity and cooperation are explained. In the following part of the essay there can be found the development of the deal-of-the-day websites on the Czech market and the demonstration the great commencement of those websites, its growth, unceasing innovations and the estimate future development, particularly in the 201...

  5. Svahoviny posledního glaciálu u Hosťovců a jejich paleoklimatická výpověď

    Czech Academy of Sciences Publication Activity Database

    Ložek, Vojen

    2012-01-01

    Roč. 2011, podzim (2012), s. 223-225 ISSN 0514-8057 Institutional research plan: CEZ:AV0Z30130516 Keywords : Slovak Karst * slope sediments * Last Glacial MIS 3 * malacofauna Subject RIV: DB - Geology ; Mineralogy http://www.geology.cz/zpravy/obsah/2011/zpravy_2011-50.pdf

  6. Iontové kapaliny a jejich polymerní analogy: nové membránové materiály

    Czech Academy of Sciences Publication Activity Database

    Žitka, Jan; Pientka, Zbyněk

    2017-01-01

    Roč. 111, č. 3 (2017), s. 192-196 ISSN 0009-2770 R&D Projects: GA MŠk(CZ) LO1507 Institutional support: RVO:61389013 Keywords : ionic liquid * polymeric ionic liquid * membrane Subject RIV: CD - Macromolecular Chemistry OBOR OECD: Polymer science Impact factor: 0.387, year: 2016 http://www.chemicke-listy.cz/common/article-vol_111-issue_3-page_192.html

  7. Práce učitelů s ADHD dětmi a jejich integrace do kolektivu třídy

    OpenAIRE

    DOMIANOVÁ, Kateřina

    2017-01-01

    This bachelor work tries to figure out how deep is knowledge of ADHD disorder in pedagogical colective. The goal of this work is to survey knowledge of pedagogue about ADHD disorder due to rising tendecies of this disorder. Another goal was to find out if it is better for child to have a personal asssistent which would help it. Or if it would not be better to leave children with this kind of a problem in specialized schools or subsume them to classic primary schools. Forty-eight pedagogue fro...

  8. Červená knihovna proti červené knihovně. Žánrové stereotypy a jejich variace

    Czech Academy of Sciences Publication Activity Database

    Holanová, Markéta

    2016-01-01

    Roč. 63, č. 2 (2016), s. 114-125 ISSN 0037-6973 Institutional support: RVO:68378068 Keywords : romance novels * Jabůrková, Jožka * Tippmannová, Marie * genre stereotypes * publishing context Subject RIV: AJ - Letters, Mass-media, Audiovision

  9. Propojení doporučených postupů pro prevenci kardiovaskulárních chorob, hypertenzi, diabetes mellitus a dyslipidemie - jejich formalizace

    Czech Academy of Sciences Publication Activity Database

    Peleška, Jan; Anger, Z.; Buchtela, David; Tomečková, Marie; Veselý, Arnošt; Zvárová, Jana

    2005-01-01

    Roč. 51, č. 10 (2005), s. 1178 ISSN 0042-773X. [Výroční kongres České internistické společnosti ČSL J.E. Purkyně /12./. 23.10.2005-25.10.2005, Praha] R&D Projects: GA AV ČR 1ET200300413 Institutional research plan: CEZ:AV0Z10300504 Keywords : počítačová prezentace lékařských doporučení * spojení několika lékařských doporučení * prevence kardiovaskulárních chorob Subject RIV: BD - Theory of Information

  10. Role starších sourozenců a jejich působení na rozvoj mladších sourozenců

    OpenAIRE

    Chytrý, Václav

    2016-01-01

    When analyzing the development of children and adolescents, the most attention is usually paid to parents. Other older members of a family, however, have an important role, too. The crucial, yet often neglected person (at least in Czech literature), impacting the development of an individual, is his or her older sibling. The subject of the theoretical part of this thesis is to clarify the specifics of a sibling relationship as well as to describe the role and the sphere of influence of the ol...

  11. Laboratorní cykly schistosom, chov mezihostitelských plžů a jejich ekologické nároky

    OpenAIRE

    Nečasová, Monika

    2016-01-01

    The Schistosomatidae family is an important group of blood flukes, including serious human and livestock animal pathogens. With regard to reproduction, they are gonochoristic parasites. Their life cycle has two stages - asexual reproduction in an intermediary host (fresh water and sea gastropods) and sexual reproduction in the definitive host (mammals and birds). With regard to their pathogenicity at the definitive hosts, the blood fluke life cycle is abundantly maintained in laboratories. To...

  12. Smlouvy o zamezení dvojího zdanění a možnosti jejich zneužití

    OpenAIRE

    Ishchenko, Iryna

    2012-01-01

    In recent years, number of initiatives arised from the European Union and OECD towards active cooperation and coordination between countries in the fight against international tax avoidance practices. The abuse of double taxation treaties and tax legislation in general became subject of increasing interest also among the Czech professional public. The aim of my thesis is to examine whether and to what extent double taxation tax treaties are used by taxpayers for purposes other than those orig...

  13. Biologická aktivita obsahových látek rostlin XXVII. Alkaloidy Fumaria officinalis L. a jejich účinek na acetylcholinesterasu a butyrylcholinesterasu.

    OpenAIRE

    Hulcová, Daniela

    2014-01-01

    Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Botany and Ecology Candidate: Daniela Hulcová Consultant: Prof. RNDr. Lubomír Opletal, CSc. Title of Diploma Thesis: Biological aktivity of plants metabolites. XXVII. Alkaloids of Fumaria officinalis L. and their effect on acetylcholinesterase and butyrylcholinesterase The summary ethanolic and diethylether extract were prepared from the herbs of a plant Fumaria officinalis L. We have obtained 201 ...

  14. Módní blogy jako specifický publicistický žánr a jejich vliv na čtenáře

    OpenAIRE

    Nyirendová, Tereza

    2016-01-01

    The main focus of the thesis is to describe the phenomenon of fashion blogs as a specific style of online writing and to analyse its influence on readers in relation to printed fashion magazines. The theoretic part describes an evolution of online media since the beginnings of Web, also in the context of generational change. It focuses on the Generation Y and its relation to online media. Furthermore, it describes internet media and internet journalism and their current tendencies. The next p...

  15. Nové možnosti geopolymerací pro výroby podlahových směsí a jejich ochrany

    Czech Academy of Sciences Publication Activity Database

    Hájek, P.; Koloušek, D.; Vavro, Martin; Souček, Kamil

    2017-01-01

    Roč. 59, č. 59 (2017), s. 7-8 ISSN 1802-2480 Institutional support: RVO:68145535 Keywords : geopolymerization * floor mixes * protection Subject RIV: JN - Civil Engineering OBOR OECD: Civil engineering http://www.czechclaygroup.cz/informatory/informator59.pdf

  16. Rané vzpomínky a jejich možnosti jako projektivního diagnostického nástroje

    Czech Academy of Sciences Publication Activity Database

    Šťástná, L.; Miovský, Michal; Polák, A.

    2004-01-01

    Roč. 48, č. 5 (2004), s. 397-409 ISSN 0009-062X Institutional research plan: CEZ:AV0Z7025918 Keywords : early memories * projective method * psychodiagnostics Subject RIV: AN - Psychology Impact factor: 0.209, year: 2004

  17. Indukce lipas v kvasinkách rodu Geotrichum a stanovení jejich stereospecificity a selektivity pro nenasycené mastné kyseliny

    Czech Academy of Sciences Publication Activity Database

    Kejík, Z.; Zarevúcka, Marie; Demnerová, K.; Wimmer, Zdeněk

    2004-01-01

    Roč. 98, č. 5 (2004), s. 284 ISSN 0009-2770. [Mezioborové setkání mladých biologů, biochemiků a chemiků /4./. 09.06.2004-12.06.2004, Žďárské vrchy] R&D Projects: GA MŠk OC D30.001; GA MŠk OC D13.10 Keywords : lipase * stereospecificity * Geotrichum Subject RIV: CC - Organic Chemistry

  18. Imobilizované fotosenzitizátory singletového kyslíku a jejich účinek na mikroorganismy

    Czech Academy of Sciences Publication Activity Database

    Rychtáriková, Renata; Kuncová, Gabriela

    2009-01-01

    Roč. 103, č. 10 (2009), s. 800-813 ISSN 0009-2770 R&D Projects: GA ČR(CZ) GA203/06/1244 Institutional research plan: CEZ:AV0Z40720504 Keywords : photosensitizer * singlet oxygen * reactive oxygen species Subject RIV: CE - Biochemistry Impact factor: 0.717, year: 2009

  19. Vláknité "kontaminanty" v mykobakteriologické laboratoři, jejich kultivace, identifikace a klinický význam

    Czech Academy of Sciences Publication Activity Database

    Scharfen ml., J.; Bunček, M.; Ježek, P.; Urbášková, P.; Fridrichová, M.; Krištůfek, Václav; Chroňáková, Alica

    2010-01-01

    Roč. 16, č. 1 (2010), s. 48-57 ISSN 1211-264X R&D Projects: GA MŠk 2B06154 Institutional research plan: CEZ:AV0Z60660521 Keywords : contamination * mycobacteriology * decontaminated samples Subject RIV: EH - Ecology, Behaviour

  20. Obsahy galia, india a thalia v granitoidech Českého masivu a jejich hlavních horninotvorných minerálech

    Czech Academy of Sciences Publication Activity Database

    Breiter, Karel; Vašinová Galiová, M.; Korbelová, Zuzana; Vaňková, M.; Kanický, V.

    2015-01-01

    Roč. 2014, č. 1 (2015), s. 79-83 ISSN 0514-8057 R&D Projects: GA ČR GA14-13600S Institutional support: RVO:67985831 Keywords : gallium * indium * thallium * granitoids * rock-forming minerals * Bohemian Massif Subject RIV: DB - Geology ; Mineralogy

  1. Příprava C2 symetrických bipyridin-N,N'-dioxidů a jejich využití v organokatalýze

    Czech Academy of Sciences Publication Activity Database

    Hrdina, R.; Valterová, Irena; Hodačová, Jana; Kotora, Martin

    2007-01-01

    Roč. 101, č. 11 (2007), s. 942 ISSN 0009-2770. [Pokroky v organické, bioorganické a farmaceutické chemii /42./. 16.11.2007-18.11.2007, Liblice] R&D Projects: GA MŠk(CZ) LC06070; GA ČR(CZ) GA203/05/0102 Institutional research plan: CEZ:AV0Z40550506 Keywords : chiral bipyridine s * enantioselective synthesis Subject RIV: CC - Organic Chemistry

  2. Staročeské lexémy nemoc, neduh a nedostatek – jejich sémantická a gramatická charakteristika

    Czech Academy of Sciences Publication Activity Database

    Černá, Alena M.

    2014-01-01

    Roč. 5, č. 10 (2014), s. 8-22 ISSN 1804-137X R&D Projects: GA ČR GAP406/10/1140 Institutional support: RVO:68378092 Keywords : Old Czech * diachronic corpus * collocation * medical terminology Subject RIV: AI - Linguistics

  3. Počátky Markvarticů a jejich sídelní souvislosti v Pojizeří

    Czech Academy of Sciences Publication Activity Database

    Klápště, Jan

    2013-01-01

    Roč. 65, č. 2 (2013), s. 321-372 ISSN 0323-1267 Grant - others:GA ČR(CZ) GAP405/10/0556 Institutional support: RVO:67985912 Keywords : Middle Ages * the early nobility * the beginnings of castles * urbanization Subject RIV: AC - Archeology, Anthropology, Ethnology

  4. Marketingové a komunikační strategie Wrigley, s.r.o. a vyhodnocování jejich efektivity

    OpenAIRE

    Konečná, Eva

    2011-01-01

    The bachelor thesis deals with marketing strategy of Wrigley Company and analyzes current methods of evaluation of their marketing activities. Theoretical part of this thesis characterizes the basic terminology used in the marketing field with an emphasis on strategic marketing and summarizes the most important marketing metrics. The practical part introduces the Wrigley Company, their marketing strategy and methods of measuring the return on their marketing investment. In the last chapter is...

  5. Pomístní jména na Moravě a ve Slezsku a jejich zpracování

    Czech Academy of Sciences Publication Activity Database

    Šipková, Milena

    2010-01-01

    Roč. 20, č. 1 (2010), s. 73-74 ISSN 0862-8351 R&D Projects: GA ČR GA405/08/0703 Institutional research plan: CEZ:AV0Z90610518 Keywords : minor place names * Dictionary of Moravian and Silesian anoikonyms * pople’s religiousness * dialect * history of settlement * local history Subject RIV: AI - Linguistics

  6. Devizové intervence ČNB a jejich vliv na zahraniční obchod ČR

    OpenAIRE

    Kramoliš, Jan

    2015-01-01

    This thesis analyzes impact of domestic currency depreciation caused by foreign exchange intervention of Czech National Bank (CNB) in November 2013 on foreign trade between Czech Republic and Eurozone. The total volume of Czech foreign trade has been growing, but in recent years Czech Republic loses price competitiveness and comparative advantage on the European market. Foreign exchange intervention promote export, but only if the J-curve occurs. Concept of the J-curve states that in the shor...

  7. Královské Vinohrady a jejich urbanizační vývoj v 19. a 20. století

    Czech Academy of Sciences Publication Activity Database

    Platovská, Marie

    2009-01-01

    Roč. 57, č. 3 (2009), s. 236-247 ISSN 0049-5123 R&D Projects: GA ČR GA408/04/1404 Institutional research plan: CEZ:AV0Z80330511 Keywords : urbanism * architecture * 19th century Subject RIV: AL - Art, Architecture, Cultural Heritage

  8. Zaměstnanecké akciové opce a jejich oceňování podle IFRS 2 na úrovni fair value

    OpenAIRE

    Červený, Martin

    2013-01-01

    This master's thesis is dealing with the topic of employee stock options (ESOs), primarily with the valuation of ESOs in accordance with the accounting standard IFRS 2 at corresponding fair value basis. The goal of this thesis is a critical analysis of the standard mentioned, with respect to the conditions of the Czech Republic. The theoretical part comes with the basic characteristics of employee stock options and explains how the traditional option-valuation models can be modified for the p...

  9. Vodní nádrže a jejich krajina ve výtvarném umění

    Czech Academy of Sciences Publication Activity Database

    Lacina, Jan; Halas, Petr

    2017-01-01

    Roč. 1, č. 1 (2017), s. 31-39 ISSN 0322-8916 Institutional support: RVO:68145535 Keywords : landscape painting * dam * landscape changes Subject RIV: DE - Earth Magnetism, Geodesy, Geography OBOR OECD: 60500 http://www.vtei.cz/wp-content/uploads/2015/08/5782-VTEI.pdf

  10. Muži a jejich životní svět v reklamách na pivo

    OpenAIRE

    Svobodová, Lucie

    2013-01-01

    This thesis deals with the widely discussed topic of gender stereotypes. Most of the attention of experts and also the general public in this area is focused on the issues of stereotypes associated with women's roles. This work attempts to inspect the other - the men's - side of gender stereotypes. The aim is to reconstruct the male stereotypes and their lifeworld in commercials which from this perspective focus on perhaps still typically masculine product: beer. The presence of traditional s...

  11. Regionální kultura Táborska, její projevy a jejich místo v cestovním ruchu

    OpenAIRE

    Doubková, Veronika

    2010-01-01

    Bachelor thesis deals with the regional culture and its connection with tourism in the town Tábor and its surroundings. Its objective is to evaluate the use of a cultural potential of the region through tourism products. Hussite tradition is Tábor's cultural potential and it is currently reflected especially in two major tourism products of Tábor. These are the historic festival called Tabor meetings and the Hussite days, which are characterized in the work.

  12. Kulturní památky v ozbrojených konfliktech: Typické motivace k jejich ničení

    OpenAIRE

    Pelikánová, Eva

    2017-01-01

    In recent years protection of cultural property in the event of armed conflicts has become largely mentioned issue. Despite broad international legal codification of principles to prevent destruction of cultural property in the event of armed conflicts, destruction of cultural property obviously occurs. Within discussion on their protection, attention is not so paid to the values of cultural property representing for interested actors not merely in the event of armed conflicts. Attention is n...

  13. Mapové podklady a jejich využití pro zpracování komplexní pozemkové úpravy

    OpenAIRE

    FLORIÁN, Ondřej

    2013-01-01

    This work includes maps of different scales, use and map projections that are used for design complex land consolidation, the differences between analog and digital maps, orthophoto use, digital cadastral map (DKM), basic geographic data base (ZABAGED).

  14. Hraní počítačových her u adolescentů ve vztahu k jejich tvořivosti

    Czech Academy of Sciences Publication Activity Database

    Zvěřinová, J.; Janošová, Pavlína

    2012-01-01

    Roč. 46, č. 2 (2012), s. 95-112 ISSN 0555-5574 R&D Projects: GA ČR(CZ) GAP407/12/2325 Institutional research plan: CEZ:AV0Z70250504 Keywords : adolescents * computer games * nonverbal creativity * verbal creativity * gender Subject RIV: AN - Psychology

  15. Rytíř Jean de Carro, Karel A. Vinařický a jejich latinská korespondence z let 1829-1843

    Czech Academy of Sciences Publication Activity Database

    span class="emphasis">Podavka, Ondřejspan>

    2011-01-01

    Roč. 134, 1-2 (2011), s. 95-119 ISSN 0024-4457 Institutional research plan: CEZ:AV0Z90090514 Keywords : reception of Antiquity * correspondence * intellectual contacts * Karel A. Vinařický * Jean de Carro Subject RIV: AB - History

  16. Public - Private - Partnership Projekty v Maďarsku a jejich mezinárodní porovnání

    OpenAIRE

    Smrčková, Gabriela

    2011-01-01

    This thesis deals with the Public Private Partnership (PPP) projects and their use as alternative forms of financing in Hungary. The work is divided into three parts. In the first part, terms that relate to PPP projects are generally defined. In addition, types of PPP projects are described, as well as the main advantages and disadvantages that come with the use of these concepts. The second part deals with the current situation on the Hungarian PPP market and provides three examples of proje...

  17. Výzkum komárů na jižní Moravě a jejich zdravotní význam

    Czech Academy of Sciences Publication Activity Database

    Šebesta, Oldřich; Rettich, F.; Peško, Juraj

    2012-01-01

    Roč. 57, č. 1 (2012), s. 4-9 ISSN 1210-7840 Institutional research plan: CEZ:AV0Z60930519 Keywords : West Nile virus * Ťahyňa virus * infectious diseases * vectors * mosquitoes * southern Moravia Subject RIV: FN - Epidemiology, Contagious Diseases ; Clinical Immunology

  18. Standardy IFRS 15 a 16 a jejich dopad na finanční výkonnost podniku

    OpenAIRE

    Hrušková, Karolína

    2017-01-01

    This diploma thesis focuses on new accounting standards IFRS 15 and IFRS 16. The aim is to examine how their implementation can affect financial performance of a company. Financial indicators reflecting these impacts are chosen based on identification of key methodical changes. The problem is described on the example of O2 Czech Republic a. s. By performing an impact analysis based on 2016 figures and currently available product and service offering, possible differences between company's res...

  19. ERP systémy a analýza jejich realizace ve webovém prostředí

    OpenAIRE

    Košař, Stanislav

    2013-01-01

    This diploma thesis deals with ERP systems and web information systems such as ERP. The theoretical part describes the historical development of information systems and the inclusion of web information systems in the context of historical development. Analysis of existing ERP systems is followed by a section dealing with the current coverage of business processes by ERP systems and general recomended criteria for choosing information systems. The practical part contains a survey of perception...

  20. Flexibilní pracovní úvazky a jejich potenciál pro kombinaci pracovního a rodinného života

    Czech Academy of Sciences Publication Activity Database

    Křížková, Alena

    2009-01-01

    Roč. 11, č. 4 (2009), s. 34-36 ISSN 1212-690X R&D Projects: GA AV ČR IAA700280804 Institutional research plan: CEZ:AV0Z70280505 Keywords : flexible work * part-time employment * work / life balance Subject RIV: AO - Sociology, Demography

  1. Stabilita úzkosti: stabilita rysu úzkosti, úzkostného stavu a jejich pozitivních a negativních složek

    Czech Academy of Sciences Publication Activity Database

    Řehulková, Oliva; Franková, E.; Osecká, Lída

    1995-01-01

    Roč. 39, č. 1 (1995), s. 12-18 ISSN 0009-062X R&D Projects: GA ČR GA406/94/1104 Keywords : anxiety * stability of anxiety * positive affectivity * negative affectivity Impact factor: 0.122, year: 1995

  2. Geopolitické změny v organizaci péče a jejich sociálněpolitické implikace

    Czech Academy of Sciences Publication Activity Database

    Hašková, Hana

    2010-01-01

    Roč. 11, č. 1 (2010), s. 92-94 ISSN 1213-0028. [Changing Social Organisation of Care and Its Implications for Social Politics. Lublan, 13.5.2010-14.5.2010] Institutional research plan: CEZ:AV0Z70280505 Keywords : care * recognition * redistribution Subject RIV: AO - Sociology, Demography http://www.genderonline.cz

  3. Nová média a jejich uplatnění v osvětových kampaních

    OpenAIRE

    Jurašková, Kateřina

    2009-01-01

    The aim of the diploma thesis "New media and their use in public awareness campaigns" is to formulate guidelines and recommendations for the use of new media in awareness campaigns. The the methods of analysis and synthesis are used in this thesis. The thesis is divided into four chapters. The first chapter deals with new media in terms of marketing communications. The second chapter focuses on the definition of social marketing and public awareness campaigns. The third chapter deals with the...

  4. Strany národnostních menšin a jejich postoje k politickému systému v ČSR

    Czech Academy of Sciences Publication Activity Database

    Rychlík, Jan

    2012-01-01

    Roč. 2011, č. 0 (2012), s. 133-145 ISSN 1214-8334 Institutional research plan: CEZ:AV0Z70900502 Keywords : Czechoslovakia (1918-1938) * political parties * national minorities Subject RIV: AB - History

  5. Cereální výrobky a jejich význam ve výživě

    OpenAIRE

    NOVOTNÁ, Jitka

    2012-01-01

    The work deals with the exploration of public awareness regarding the basic knowledgeand consumption of cereal. The theoretical part describes the composition of cereals and their utilization for human consumption. It also deals with the nutritional value of cereals and health aspects of eating cereal. Among other things, the important parts of this work include the labeling of productsmade from cereals, important for market orientation and cereals in the prevention of civilization diseases. ...

  6. Výroba čokoládových cukrovinek a faktory ovlivňující jejich udržitelnost

    OpenAIRE

    Jurková, Jena

    2015-01-01

    Bachelor thesis deals with the technology of production of chocolate and influences affecting their sustainability. There are described all process steps from the processing of cocoa beans to actual production of chocolate, which includes pressing, rolling, conching and tempering. Finally there is shown forming, cooling and packaging of chocolate products themselves. There is a brief history, characteristics of the cacao tree and its varieties and basic raw material for the production of choc...

  7. Média a jejich vliv na delikventní chování dětí a mladistvých

    OpenAIRE

    JANOUCHOVÁ, Veronika

    2010-01-01

    The Thesis "Media and their impact on delinquent behaviour of children and youth" studies possible effects of media on children and youth who have committed an offence. The influence of media on modern societies is substantial and still increasing, which is why its affect on a human is being more and more discussed. The influence of media on children and youth seems to be particularly important. High degree of influence by external factors, including that of media belongs to the basic factors...

  8. Gesta v současné španělštině a jejich role v jazykové komunikaci

    OpenAIRE

    Johánková, Tereza

    2008-01-01

    This diploma thesis focuses on gestures in contemporary Spanish and their role in linguistic communication. It contains the definitions of basic terms, the introduction, five major parts, the conclusion and five appendices with pictures and charts. Some of the appendices include videos. Since this diploma work does not concern only gestures but also communication, its first part concentrates on language, communication and their mutual relationship. First, language, its division, types, functi...

  9. Videohry, literární předlohy a filmové adaptace a jejich vliv na hráčskou komunitu

    OpenAIRE

    Přichystal, Jan

    2017-01-01

    Cílem této práce je popsat postupy používané při převádění knihy do podoby videohry, hlavní aspekty tohoto procesu, změny v daných médiích, které při tomto procesu probíhají a popsat spojení vznikající mezi videohrami, literaturou a filmy. Nastíní také některé z nových technologií používaných při vývoji videoher. Hlavní témata této práce budou demonstrována na sérii knih, seriálu a populárním RPG Zaklínač, původně vytvořené polským spisovatelem Andrzejem Sapkowským. V porovnání s těmito popul...

  10. Vliv aminokyselin produkovaných fytoplanktonem na úpravu vody a jejich adsorpce na aktivním uhlí

    Czech Academy of Sciences Publication Activity Database

    Čermáková, Lenka; Pivokonská, Lenka; Kopecká, Ivana; Pivokonský, Martin; Janda, V.

    2016-01-01

    Roč. 110, č. 6 (2016), s. 418-423 ISSN 0009-2770 Institutional support: RVO:67985874 Keywords : activated carbon * adsorption * algal organic matter * amino acids Subject RIV: BK - Fluid Dynamics Impact factor: 0.387, year: 2016 http://www.chemicke-listy.cz/docs/full/2016_06_418-423.pdf

  11. Vysoké kotvení v chodbách pro dvojí použití a jejich monitoring

    Czech Academy of Sciences Publication Activity Database

    Kukutsch, Radovan; Souček, Kamil; Koníček, Petr; Ptáček, Jiří

    2012-01-01

    Roč. 19, říjen (2012), s. 24-28 ISSN 1210-7697. [Hornická Příbram ve vědě a technice 2012 /51./. Příbram, 16.10.2012-18.10.2012] R&D Projects: GA MŠk ED2.1.00/03.0082; GA MV VG20102014034 Institutional support : RVO:68145535 Keywords : high anchoring * dual use corridors * cable bolt loading Subject RIV: DH - Mining , incl. Coal Mining

  12. Volby do Poslanecké sněmovny České republiky 2010 a jejich „alternativní“ výstupy

    Directory of Open Access Journals (Sweden)

    Michal Pink

    2010-08-01

    Full Text Available The 2010 Czech Parliamentary Elections and Their “Alternative” Outcomes. The article deals with the electoral competition into the House of Deputies in Czech Republic. First, it provides an overview of existing results and shows the possibility of alternatives through mathematical models simulating the creation of pre-election coalitions between various political parties. Secondly, the text shows the alternative results that would follow a hypothetical lowering of the 5% administrative threshold. The data source used in the article is based on the electoral results of the last general parliamentary election in the Czech Republic in May 2010.

  13. Aktéři lokálního rozvoje a jejich vzájemná spolupráce

    Czech Academy of Sciences Publication Activity Database

    Bernard, Josef

    2009-01-01

    Roč. 7, č. 2 (2009), s. 8-10 ISSN 1214-1720 R&D Projects: GA MŠk 2D06006 Institutional research plan: CEZ:AV0Z70280505 Keywords : local development * urban sociology * social networks Subject RIV: AO - Sociology, Demography http://www.socioweb.cz/index.php?disp=teorie&shw=379&lst=106

  14. Rozšíření architektury frameworku pro analýzu a vizualizaci RDF dat a vizualizačních pluginů

    OpenAIRE

    Kudláček, Ondřej

    2017-01-01

    This extension of Payola framework focuses on user experience. Payola is a web application which allows to visualize Linked Data via its visual plugins. The data can be displayed as graphs, tables, etc. Payola also allows to construct analysis using SPARQL language and browse the analyzed data structures without any need of deep knowledge of SPARQL. The extension is placed between the Payola server and users web browser to increase the visual plugins responsiveness.

  15. Serological evidence of Leishmania donovani infection in apparently healthy dogs using direct agglutination test (DAT) and rk39 dipstick tests in Kafta Humera, north-west Ethiopia

    NARCIS (Netherlands)

    Kalayou, S.; Tadelle, H.; Bsrat, A.; Abebe, N.; Haileselassie, M.; Schallig, H. D. F. H.

    2011-01-01

    Leishmania (Kinetoplastida: Trypanosomatidae) are protozoan parasites of significant medical and veterinary importance. Over the last decade, visceral leishmaniasis (VL) has emerged as a major opportunistic infection associated with HIV/AIDS in North Western Ethiopia. This paper reports on

  16. A study on the thermal decomposition behavior of derivatives of 1,5-diamino-1H-tetrazole (DAT): A new family of energetic heterocyclic-based salts

    International Nuclear Information System (INIS)

    Fischer, Gerd; Holl, Gerhard; Klapoetke, Thomas M.; Weigand, Jan J.

    2005-01-01

    The thermal decomposition of the highly energetic 1,5-diamino-4-methyl-1H-tetrazolium nitrate (2b), 1,5-diamino-4-methyl-1H-tetrazolium dinitramide (2c) and 1,5-diamino-4-methyl-1H-tetrazolium azide (2d) were investigated by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). Mass spectrometry and IR spectroscopy were used to identify the gaseous products. Decomposition appears in the cases of 2c and 2d to be initiated by a proton transfer to form the corresponding acid HN 3 and HN 3 O 4 whereas in the case of 2b a methyl group transfer to MeONO 2 is observed as initial process. The gaseous products after the exothermic decomposition are comparable and are in agreement of the possible decomposition pathways discussed for the corresponding compounds. For all processes, possible decomposition schemes are presented. The decomposition temperatures of 2b and 2c are significantly higher than that of 2d and were supported by evaluation the values of the activation energy according the method of Ozawa and Kissinger

  17. Non invasive diagnostic tools for visceral leishmaniasis: a comparison of the immunoserological tests DAT, rK26 and rK39

    NARCIS (Netherlands)

    Teran-Angel, G.; Rodriguez, V.; de Silva, R.; Zerpa, O.; Schallig, H.; Ulrich, M.; Cabrera, M.

    2010-01-01

    Introduction. Human visceral leishmaniasis is a serious public health problem in endemic countries because of its high potential lethality, particularly in children. Rapid diagnosis is essential to early treatment and control of visceral leishmaniasis. Objective. The aim was to compare three

  18. ADHD : Dat valt niet mee! Een onderzoek naar de invloed van sociale steun op het functioneren en de kwaliteit van leven bij volwassenen met ADHD

    NARCIS (Netherlands)

    Bouwsema, G.

    2006-01-01

    De aanleiding van dit onderzoek is afkomstig van de patiëntenvereniging voor volwassenen met ADHD (‘Impuls’). In samenwerking met de Wetenschapswinkel Geneeskunde en Volksgezondheid van het UMCG is besloten onderzoek te gaan verrichten naar de invloed van sociale steun op het functioneren en de

  19. Algoritmus detekující změny průběhu experimentálních dat

    Czech Academy of Sciences Publication Activity Database

    Zezulka, Petr

    2001-01-01

    Roč. 72, č. 279 (2001), s. 97-100 ISSN 1429-6055. [Międzynarodowe Sympozjum - Metody oceny struktury oraz własnosci materiałow i wyroboów /16./. Komorní Lhotka, 11.12.2001-13.12.2001] Institutional research plan: CEZ:AV0Z2041904 Keywords : algorithm Subject RIV: BA - General Mathematics

  20. Digitizing instrumentation and control systems in nuclear power plants. DAtF autumn meeting Leittec '96, October 8, 1996 in Koenigswinter

    International Nuclear Information System (INIS)

    Aleite, W.

    1997-01-01

    Recently, digitization for upgrading and retrofitting of instrumentation and control systems has been extended to German nuclear power plants, and initial action to commence modification started with a very suitable system, the limiters of the Neckar-1 reactor unit of GKN. This action is generally welcomed. Systems of the control room of relevance to safety -even if not belonging to priority classes - are systems for process information for example, or operator guidance, as well as diagnostic systems for inspection and maintenance. (orig./DG) [de

  1. Využití Linked Data pro sdílení dat o smlouvách veřejných institucí

    OpenAIRE

    Hryzlík, Pavel

    2016-01-01

    Title: Exploitation of Linked Data for sharing public agreements data Author: Bc. Pavel Hryzlík Department: Department of Software Engineering Supervisor: Doc. Mgr. Martin Nečaský, Ph.D., Department of Software Engineering Abstract: The objective of the thesis is to explore the possibilities of using Linked Data principles for publishing and sharing data on contracts of public institutions and their connections to related data in the public domain (eg. Business and trade register, register of...

  2. Predikce rizika vzniku přívalové povodně s využitím dat meteorologických radarů

    Czech Academy of Sciences Publication Activity Database

    Rapant, P.; Kolejka, Jaromír; Inspektor, T.

    2016-01-01

    Roč. 50, č. 3 (2016), s. 162-166 ISSN 0044-4863 R&D Projects: GA MV VG20132015106 Institutional support: RVO:68145535 Keywords : flash floods * prediction * weather radar * early warning Subject RIV: DE - Earth Magnetism, Geodesy, Geography http://147.213.211.222/sites/ default /files/2016_3_162_166_Rapant_a_kol.pdf

  3. Etika vykazování účetních dat ve vazbě na předpisy ČR

    OpenAIRE

    PATÁKOVÁ, Aneta

    2013-01-01

    The aim of my thesis was to analyse the current ethics of financial reporting in the Czech Republic and to propose a motion how to improve it. The theoretical part describes the historical development of business ethics, accounting ethics and the codes of ethics. It also includes the theory of accounting frauds and financial reporting of accounting in the Czech Republic. The practical part of this thesis includes an analysis of the current ethical situation of financial reporting in the Czech...

  4. Testování modelu rozšíření Ledum palustre L. pomocí paleoekologických dat

    Czech Academy of Sciences Publication Activity Database

    Radoměřský, T.; Kuneš, P.; Bobek, Přemysl

    2017-01-01

    Roč. 50, č. 1 (2017), s. 65-71 ISSN 0514-8057 Institutional support: RVO:67985939 Keywords : species distribution modelling * Holocene * pollen analysis Subject RIV: EH - Ecology, Behaviour OBOR OECD: Plant sciences, botany

  5. A 40-bp VNTR polymorphism in the 3'-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism

    Czech Academy of Sciences Publication Activity Database

    Šerý, Omar; Paclt, I.; Drtílková, I.; Theiner, P.; Kopečková, M.; Zvolský, P.; Balcar, V. J.

    2015-01-01

    Roč. 11, č. 1 (2015), s. 21-28 ISSN 1744-9081 R&D Projects: GA MZd NT14504 Institutional support: RVO:67985904 Keywords : hyperkinetic disorder * polymorphism * alcoholism Subject RIV: FQ - Public Health Care, Social Medicine Impact factor: 1.720, year: 2015

  6. Seismické a lokální účinky (analýza dat a modelování)

    OpenAIRE

    Caserta, Arrigo

    2011-01-01

    A comprehensive study of the soil shaking under the seismic wave-field ex- citation is presented. It includes theoretical, geological, geotechnical, data analysis and numerical simulations aspects. The aim is to quantify the main parameters allowing the estimate of the soil shaking in urban areas for better mitigating seismic risk due to future earthquakes. The city of Rome has been chosen as a case study because of its high density of popula- tion and large concentration of historical monume...

  7. Influence of DAT1 and COMT variants on neural activation during response inhibition in adolescents with attention-deficit/hyperactivity disorder and healthy controls

    NARCIS (Netherlands)

    van Rooij, D.; Hoekstra, P. J.; Bralten, J.; Hakobjan, M.; Oosterlaan, J.; Franke, B.; Rommelse, N.; Buitelaar, J. K.; Hartman, C. A.

    2015-01-01

    Background. Impairment of response inhibition has been implicated in attention-deficit/hyperactivity disorder (ADHD). Dopamine neurotransmission has been linked to the behavioural and neural correlates of response inhibition. The current study aimed to investigate the relationship of polymorphisms

  8. Minder bureaucratie dankzij Lean Six Sigma: Project in UMCG toont aan dat ook administratieve processen met LSS efficiënter worden

    NARCIS (Netherlands)

    van Rensen, M.; Kluter, L.; Does, R.; Trip, A.

    2008-01-01

    De Lean Six Sigma methode is toegepast voor een analyse van de procedure rond langdurig ziekteverzuim. De werkgever heeft de wettelijke plicht een langdurig zieke te helpen reïntegreren in het arbeidsproces. De eerste twee jaar blijft de zieke medewerker ook nog in dienst, zodat de werkgever

  9. Dolovací modul systému pro dolování z dat na platformě NetBeans

    OpenAIRE

    Výtvar, Jaromír

    2010-01-01

    Cílem této diplomové práce je získat přehled o procesu získávání znalostí z databází a analýza dolovacího systému vyvíjeného na FIT VUT v Brně na platformě NetBeans za účelem vytvoření nového dolovacího modulu. Ze získaných znalostí bylo rozhodnuto o vytvoření modulu pro dolování odlehlých hodnot a doplnění existujícího modulu regrese o nový algoritmus vícenásobné lineární regrese založený na zobecněných lineárních modelech. Nové dolovací metody využívají existující řešení na straně Oracle da...

  10. THERMOKINETIC STUDY OF THE ZERO, FIRST AND SECOND ORDER REACTIONS IN A PSEUDO-ADIABATIC CALORIMETER: Numerical approach and experimental dat

    Directory of Open Access Journals (Sweden)

    Johanna Mendoza

    2012-11-01

    Full Text Available The signal produced by a pseudo-adiabaticcalorimeter is simulated by numericalsolution of the differential equations thatmodel the chemical kinetics [1], the thermalproperties of the calorimetric cell[2], and the response of the thermistorused as a thermometric sensor [3]. These equations show that the calorimetricsignal is related with concentrationin a complex way. Therefore, a comparisonbetween the signals of the threebasic kinetics reactions (zero, first andsecond order was made, as a first stepto obtain a standard procedure to followchemical kinetics using a calorimeter. Inorder to help understanding this relationship,the initial rate method was applied to the simulated data to assess the relationshipbetween the order and the kineticconstants calculated with those usedfor the simulations. As it was expected,the initial rate method for the calorimetricdata, do not give a slope directly relatedwith the order of the reaction, as itwould be produced, for example, in datafrom a spectrophotometer. However, alinear relationship was found betweenwhat we call the “calorimetric order”and the kinetic order. Finally, the developedprocedure was applied to the studyof the H2O2 decomposition catalyzedwith Fe3+ in homogeneous phase andwith activated carbon in heterogeneousphase, finding the order and the kineticsconstants of the global processes, whichwere in close agreement with those inthe literature.

  11. Akutní infarkt myokardu u pacientů s diabetem a nediabetiků. Podle dat z registru ALERT-CZ

    Czech Academy of Sciences Publication Activity Database

    Hanuš, P.; Reissigová, Jindra; Grünfeldová, H.; Svobodová, I.; Janský, P.; Monhart, Z.; Widimský, P.; Vojáček, J.; Zvárová, Jana

    2010-01-01

    Roč. 52, č. 9 (2010), s. 578-578 ISSN 0010-8650. [Konference České společnosti pro hypertenzi /27./, Konference pracovní skupiny Preventivní kardiologie ČKS /19./, Konference pracovní skupiny Srdeční selhání ČKS /15./. 07.10.2010-09.10.2010, Mariánské Lázně] R&D Projects: GA MŠk(CZ) 1M06014 Institutional research plan: CEZ:AV0Z10300504 Keywords : akutní infarkt myokardu * diabetes mellitus * rizikové faktory aterosklerózy Subject RIV: IN - Informatics, Computer Science

  12. Možnosti detekce drenáží a melioračních kanálů z dat DPZ

    OpenAIRE

    Čermák, Jan

    2015-01-01

    The purpose of this work is to explore detection options of subsurface drainage systems using remote sensing data. Drainage drains soggy soil and increases its fertility, but also allows transport of nutrients such as nitrogen and phosporus into waterways. Location of drainage systems is often unknown because of missing or inacurrate project documentation. Theoretical part is mostly devoted to the description of remote and ground methods of drainage detection. Then objectives of the work are ...

  13. Možnosti získávání prostorových dat v prostředí internetu.

    OpenAIRE

    DOHNAL, Vojtěch

    2013-01-01

    Paper maps become a thing of the past at the time of Internet and navigation technologies. With the advent of new technologies present maps are created in digital form by vector drawing and old maps are transformed into digital ones. These data can be also published on the Internet and it is also possible to work with them in Geographic information system. In this work I tried to study, describe and compare possibilities which are offered by various web interfaces.

  14. Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux

    DEFF Research Database (Denmark)

    Binda, Francesca; Dipace, Concetta; Bowton, Erica

    2008-01-01

    of the dopamine (DA) transporter (DAT) as the site of direct interaction with SYN1A. Amphetamine (AMPH) increases the association of SYN1A with human DAT (hDAT) in a heterologous expression system (hDAT cells) and with native DAT in murine striatal synaptosomes. Immunoprecipitation of DAT from the biotinylated...

  15. Důraz školy na akademický úspěch: TIMSS 2011 jako sonda do reformy v České republice/ School emphasis on academic success in TIMSS 2011 as a window on curricular reform in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Dominik Dvořák

    2015-04-01

    Full Text Available V šetření TIMSS 2011 se objevil index nazvaný „důraz školy na studijní úspěch“ (SEAS. Cílem článku je osvětlit skutečnost, že české školy vykazují poměrně nápadné hodnoty tohoto indexu. Dále pomocí SEAS analyzuje vztah mezi postoji českých škol k reformě a znalostmi a dovednostmi jejich žáků. Teoretický úvod popisuje konstrukt akademický optimismus a index SEAS zavedený v šetření TIMSS. Následně je provedena explorativní sekundární analýza dat o úrovni složek SEAS v případě českých škol se zaměřením na nápadné odchylky hodnot. Práce vychází z výsledků žáků čtvrtých ročníků v matematickém testu TIMSS 2011 a z odpovídajících učitelských a ředitelských dotazníků. Pro analýzu vztahů v datech jsou použity základní prostředky popisné a inferenční statistiky. Zjištění ukazují na disproporčně nízkou důvěru ředitelů ve snahu žáků ve škole dobře prospívat, která je společná regionálnímu klastru zemí. Dále analýza přinesla nečekaná zjištění o vztahu mezi postoji ředitelů a učitelů ke kurikulární reformě a výsledky jejich žáků v matematice. Z literatury známá i naše původní zjištění o komponentách indexu SEAS v podmínkách českých škol přinášejí zajímavé pohledy mj. na vnímání reformních procesů v českých školách a doplňují tak literaturu o implementaci, resp. recepci reformy.

  16. Bariéry v zaměstnávání bývalých uživatelů drog a jejich uplatnitelnost na trhu práce

    OpenAIRE

    Jakešová, Ivana

    2011-01-01

    This thesis deals with the reintegration of persons recovering from drug addiction and their return to the labour market. The reintegration model is chosen by social company, Café Therapy, one of the first social enterprises to focus specifically on the re-employment of individuals. The main goal of this work is to analyse how successful the company has been, in terms of social effectiveness and self-sufficiency and whether or not the funds invested return by way of the tax system. The object...

  17. Psárky Alopecurus aequalis a A. geniculatus v České republice: jejich určování a rozšíření

    Czech Academy of Sciences Publication Activity Database

    Bureš, P.; Danihelka, Jiří; Husáková, M.; Pařil, P.

    2008-01-01

    Roč. 23, - (2008), s. 3-61 ISSN 0862-2035 R&D Projects: GA MŠk(CZ) LC06073; GA ČR(CZ) GA206/07/0706 Institutional research plan: CEZ:AV0Z60050516 Keywords : phytogeography * Poaceae * Central Europe Subject RIV: EF - Botanics

  18. Vývoj sociálních sítí a jejich využití v marketingové strategii značek

    OpenAIRE

    Malíková, Kateřina

    2010-01-01

    The thesis deals with development of social networks, their characteristics and characteristics of users from global and regional point of view. The main part of the thesis is concerning social media marketing. It describes and analyzes current situation in social media marketing between firms and the most important aspects of brand strategies within social media. Finally, the thesis shows the aspects on examples of the most successful brands in social media marketing.

  19. Využití kotevních systémů v hlubinných dolech OKR a testování jejich únosnosti

    Czech Academy of Sciences Publication Activity Database

    Souček, Kamil; Koníček, Petr; Staš, Lubomír; Šňupárek, Richard; Ptáček, Jiří

    2012-01-01

    Roč. 21, č. 2 (2012), s. 4-10 ISSN 1211-0728 R&D Projects: GA MŠk ED2.1.00/03.0082; GA MV VG20102014034 Institutional research plan: CEZ:AV0Z30860518 Keywords : anchoring systems * underground mines * resistance testing Subject RIV: DH - Mining, incl. Coal Mining http://www.ita-aites.cz/files/tunel/komplet/tunel_2_12.pdf

  20. Knihovny v Dačicích a okolí a jejich vliv na volný čas dětí a mládeže

    OpenAIRE

    KOPŘIVOVÁ, Šárka

    2014-01-01

    The theses deals with libraries in Dačice and its surroundings and with their influence on children and teenagers' free time activities. In the theoretical part basic terms (such as free time, library, reader) have been explained. The library system in the Czech Republic, how it works, its functions and departments have also been specified. In this part libraries in Dačice area have been introduced. The Municipal Library in Dačice and in Budíškovice have been introduced in detail. The theses ...

  1. Očekávání žen/klientek od odborného sociálního poradenství v jejich obtížné životní situaci

    OpenAIRE

    ERHARTOVÁ, Nikola

    2015-01-01

    The aim of the bachelor thesis called "Expectations of Female Clients of the Professional Social Counselling In Their Difficult Life Situation" is to cover what kind or form of help these clients expect.The thesis is devided into two large parts. The theoretical part comprises of four main chapters. The first chapter ís called "Counselling in Social Services", and specifies professional social counselling and connected topics, such as counselling relationship, professionality and personality ...

  2. Srovnání CSR aktivit firem působících na českém trhu a jejich přínos pro veřejnost

    OpenAIRE

    Říhová, Lucie

    2016-01-01

    The paper focuses on evaluation of corporate social responsibility in Starbucks and Tchibo. To fulfil this aim is used the analysis of CSR activities of companies mentioned above. The indispensable part of this paper is also research in form of a questionnaire, that investigates the public awareness of sustainable activities and it´s attitude to this issue. In the first part of this paper can be found a theoretical introduction to the problem, two following chapters are focused on Starbucks a...

  3. Porovnání chromatografických metod pro stanovení ergosterolu a jejich využití při analýze půdy podhorské pastviny

    Czech Academy of Sciences Publication Activity Database

    Jirout, Jiří; Tříska, Jan; Růžičková, Kamila; Vrchotová, Naděžda; Šimek, Miloslav; Elhottová, Dana

    2010-01-01

    Roč. 104, č. 11 (2010), s. 1053-1059 ISSN 0009-2770 R&D Projects: GA MŠk LC06066; GA AV ČR IAA600660605 Institutional research plan: CEZ:AV0Z60660521; CEZ:AV0Z60870520 Keywords : ergosterol * GC-MS-MS * HPLC Subject RIV: EH - Ecology, Behaviour Impact factor: 0.620, year: 2010

  4. Sociálně demokratické strany v ČR, Maďarsku a na Slovensku a jejich pozice k zavedení Evropského stabilizačního mechanismu

    Directory of Open Access Journals (Sweden)

    Pavlína Janebová

    2016-08-01

    Full Text Available The article examines the positions of the Czech, Hungarian and Slovak social democratic political parties on the introduction of the permanent European Stability Mechanism as a means of addressing the economic and debt crisis in the EU. Using the categories of frames used by political parties in relation to the EU (utilitarian and cultural introduced by Helbling et al., the political parties’ representatives’ speeches and written statements are analyzed. The analysis showed that all three of the parties use similar arguments and they tend to frame their opinions in both utilitarian and cultural terms with the category of “political efficiency” being the most frequent. While the most extensive debate about the issue was in Slovakia as the only Eurozone member of all three given countries, the Hungarian MSzP was able to conceive the topic in a broader context. The similarity of the positions of all three examined parties may indicate an ability of national political parties to constitute one of the key pillars in developing a supranational political system in the EU.

  5. Mocní a jejich hry: hrací kostky v rukách příslušníků elit doby římské

    Czech Academy of Sciences Publication Activity Database

    Šedo, Ondrej; Knápek, Radka

    2017-01-01

    Roč. 19, prosinec (2017), s. 25-34 ISSN 1213-1628 Institutional support: RVO:68081758 Keywords : astragals * dice * game stones * board games * antics * roman period * barbaricum Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: Archaeology

  6. Zásady grafického designu a jejich aplikace na příkladu balení výběrové kávy

    OpenAIRE

    Tsitova, Darya

    2017-01-01

    This thesis is focused on study of the main principles in creation of packaging design. The theoretical part is dealt with the concept of packaging design in the selective segment of speciality coffee and graphic design principles that can be applied to this packaging. The practical part these principles are studied to redesign graphic identity for the package design of the selective brand of speciality coffee. One section of the practical part is also the analysis of the state of concrete pa...

  7. Nádory děložního čípku, jejich terapie a vyšetření nádorových markerů

    Czech Academy of Sciences Publication Activity Database

    Nekulová, M.; Kalábová, R.; Pecen, Ladislav; Šimíčková, M.; Neumannová, R.; Valík, D.

    -, č. 4 (2003), s. 4-6 ISSN 1211-5665 Institutional research plan: CEZ:AV0Z1030915 Keywords : nádorové markery * terapie * nádor děložního čípku * nádory vaječníků Subject RIV: BB - Applied Statistics, Operational Research

  8. Rizika vyplývající z činnosti vybraného podnikatelského subjektu a možnost jejich eliminace pojištěním

    OpenAIRE

    PAVLOVÁ, Eva

    2008-01-01

    Risks implicit in enterprise activities castle Dobříš and the possibility their elimination insurance. Analyse risks whit risk management and whit SWOT analyse and the project precaution. Insurance of buildings, species insurance, proprietary insurance, airport and airmeeting, cover against theft, fire insurance, insurance against natural hazards.

  9. Znaky pro barvy v českém znakovém jazyce a jejich etymologie / Colour Terms in the Czech Sign Language and Their Etymology

    Directory of Open Access Journals (Sweden)

    Lenka Okrouhlíková

    2016-06-01

    Full Text Available The text deals with the signs in the Czech Sign Language for the basic colours — white, black, red, green, yellow, blue, brown and grey in the diachronic point of view. On the basis of historical written description of these signs from 1834–1907 the motivation of the signs is being analysed (the signs were derived from the typical object of the particular colour as well as the slow lexicalization and form (especially the components of the signs — the place of articulation, handshape and movement. At the same time, the historical signs are compared to the current signs and the text provides analysis of the trends in changes of phonological/morphological structures of the signs (place of articulation changes — moving down from the center to the periphery of the face, shortening of the movement, changing the shape of the hand etc.. In addition the text examines the possible relationship of these signs with the signs for colours in the Austrian, German and French Sign Language (the languages that had been used in deaf education at the end of the 18th and 19th centuries according to preserved records. Concerning the historical signs their motivation and form were compared, along with the detail look at the contemporary signs. This is the first look at the Czech Sign Language from the etymological point of view at all.

  10. Analýza CSR aktivit společnosti T-Mobile Czech Republic, a.s. a jejich porovnání se strategií mateřské společnosti Deutsche Telekom

    OpenAIRE

    Ježková, Ivana

    2008-01-01

    The thesis deals with compilation of CSR activities of T-Mobile Czech Republic, a.s., their inclusion in the CSR strategy of Deutsche Telekom AG and suggestion how to conform current activities to the CSR strategy of Deutsche Telekom AG. The first part of the thesis explains what CSR is, how can we identify responsible company and deals with the question of importance of CSR. In the second part there is an information about T-Mobile Czech Republic and Deutsche Telekom, list of CSR activities ...

  11. Karolinské importy a jejich napodobování v Čechách, případně na Moravě (konec 8. - 10. století)

    Czech Academy of Sciences Publication Activity Database

    Profantová, Naďa

    Suppl. 4, - (2011), s. 71-104 ISSN 1336-6637. [Karolínska doba a Slovensko. Bratislava, 23.02.2010] Institutional research plan: CEZ:AV0Z80020508 Keywords : Carolingian imports * Bohemia * Early Middle Ages * military equipment * weapons * luxurious jewellery Subject RIV: AC - Archeology, Anthropology, Ethnology

  12. Pojmenování barev a jejich odstínů v Akademickém slovníku současné češtiny

    Czech Academy of Sciences Publication Activity Database

    Lišková, Michaela; Pernicová, Helena

    2015-01-01

    Roč. 97, č. 2 (2015), s. 169-178 ISSN 0008-7386 R&D Projects: GA MK DF13P01OVV011 Keywords : monolingual dictionary * explanation of the meaning * compound adjectives * names of colours Subject RIV: AI - Linguistics http://bit.ly/1MBb0Pm

  13. Příběh tří Mikulášů od Věže. Příspěvek k otázce jejich totožnosti

    Czech Academy of Sciences Publication Activity Database

    Musílek, Martin

    2013-01-01

    Roč. 29, č. 1 (2013), s. 2-15 ISSN 0231-6056 R&D Projects: GA ČR(CZ) GAP405/11/1982 Institutional support: RVO:67985955 Keywords : Prague * Prague’s Old Town * Brno * Tišnov * town elite * town seals * town genealogy Subject RIV: AB - History

  14. Elektrické výboje ve vodě a jejich využití k čištění vody a v medicíně

    Czech Academy of Sciences Publication Activity Database

    Lukeš, Petr; Šunka, Pavel; Člupek, Martin; Babický, Václav; Hoffer, Petr; Šimek, Milan; Stelmashuk, Vitaliy

    2009-01-01

    Roč. 59, č. 4 (2009), s. 202-206 ISSN 0009-0700 R&D Projects: GA AV ČR IAAX00430802; GA ČR GA202/09/1151 Institutional research plan: CEZ:AV0Z20430508 Keywords : non-thermal plasma * electrical discharge * water treatment * biomedicine Subject RIV: BL - Plasma and Gas Discharge Physics

  15. Geofyzikální indikace pohřbených variských intruzí a jejich význam pro rojovou seismicitu v západních Čechách

    Czech Academy of Sciences Publication Activity Database

    Novotný, Miroslav

    2012-01-01

    Roč. 116, č. 1 (2012), s. 12-16 ISSN 0232-0738 R&D Projects: GA MŠk LA08036 Institutional support: RVO:67985530 Keywords : Bohemian Massif * West Bohemian seismogenic swarm zones * focal domains Subject RIV: DC - Siesmology, Volcanology, Earth Structure

  16. Nové formy komerčních komunikací a jejich využití v kreativních průmyslech

    OpenAIRE

    Fidrmucová, Naďa

    2012-01-01

    The thesis "New forms of Commercial communications and their use in the Creative industries" is focused on two phenomena of our time. The new forms of commercial communication like response to the abandonment of traditional communication methods, channels and media. The second phenomenon is the creative industries as an opportunity for the new economy. This work includes the analysis of specifics of marketing communication in the creative industries, analysis of commercial communication and i...

  17. Pohybové aktivity ve vodě pro seniory a jejich vliv na zdraví s využitím intervenčního programu.

    OpenAIRE

    PRAŽÁK, Jaromír

    2012-01-01

    Old age is a natural and irreversible process of human development, which is associated with significant physiological, psychological and social changes. Active life of seniors and implementation of adequate physical activity is the cornerstone for achieving high-quality, healthy and full of life. The aim of this study was to develop, validate and identify practical physical and mental changes related to the intervention program and processed at the same time integrating the program into dail...

  18. Olivovité korálky v raně středověkých Čechách a jejich postavení ve středoevropském kontextu

    Czech Academy of Sciences Publication Activity Database

    Košta, J.; Tomková, Kateřina

    2011-01-01

    Roč. 102, - (2011), s. 307-354 ISSN 0031-0506 R&D Projects: GA ČR GA404/09/1135; GA AV ČR IAA800020903 Institutional research plan: CEZ:AV0Z80020508 Keywords : glass-making * beads * Early Middle Ages * chemical analyses * Central Europe Subject RIV: AC - Archeology, Anthropology, Ethnology

  19. Štípatelné břidlice České republiky a petrografické metody pro hodnocení kvality jejich stavebního užití

    Czech Academy of Sciences Publication Activity Database

    Daněk, T.; Vavro, Martin; Moučka, L.

    2013-01-01

    Roč. 12, 1-2 (2013), s. 15-19 ISSN 1213-7308 Institutional support: RVO:68145535 Keywords : roofing slate * building use * quality * petrographic methods * mining history Subject RIV: JN - Civil Engineering

  20. Zpevněné povrchy puklin v kvádrovém pískovci a jejich role při vzniku skalních měst

    Czech Academy of Sciences Publication Activity Database

    Bruthans, J.; Soukup, J.; Světlík, D.; Schweigstillová, Jana; Mayo, A.L.

    2013-01-01

    Roč. 46, Prosinec (2013), s. 109-115 ISSN 0514-8057 R&D Projects: GA ČR GA13-28040S Institutional support: RVO:67985891 Keywords : sandstone landforms * deformation bands * erosion * fractures Subject RIV: DB - Geology ; Mineralogy http://www.geology.cz/zpravy/obsah/2012/Zpravy_2012-20.pdf

  1. Šlechtické kapely v českých zemích doby baroka: staré a nové otázky jejich zkoumání

    Czech Academy of Sciences Publication Activity Database

    Kapsa, Václav

    2014-01-01

    Roč. 3, č. 1 (2014), s. 177-182 ISSN 1803-7747 Institutional support: RVO:68378076 Keywords : history of music * Bohemian lands * music ensembles * Kapellen * aristocracy Subject RIV: AL - Art, Architecture, Cultural Heritage http://www.acecs.cz/ media /cu_2014_03.pdf

  2. Těžké kovy v čistírenském kalu a jejich chování při spalování

    Czech Academy of Sciences Publication Activity Database

    Hartman, Miloslav; Trnka, Otakar

    2008-01-01

    Roč. 102, č. 2 (2008), s. 131-138 ISSN 0009-2770 R&D Projects: GA AV ČR(CZ) IAA4072201 Institutional research plan: CEZ:AV0Z40720504 Keywords : sewage sludge * combustion * heavy metals Subject RIV: CI - Industrial Chemistry, Chemical Engineering Impact factor: 0.593, year: 2008

  3. Historické knižní fondy v České republice a současný stav jejich knihovnického zpracování

    Czech Academy of Sciences Publication Activity Database

    Baďurová, Anežka

    2003-01-01

    Roč. 53, č. 2 (2003), s. 641-684 ISSN 0036-5246 Institutional research plan: CEZ:AV0Z7083919 Keywords : historical book collections * historical bibliography * book culture Subject RIV: AF - Documentation, Librarianship, Information Studies

  4. Subjektivní a objektivní dimenze lidské práce: napětí při jejich realizaci ve firemní praxi

    OpenAIRE

    Roubal, Tomáš

    2013-01-01

    Subjective and objective dimension of human work: the tension in their realisation in corporate experience thesis / Tomáš Roubal The thesis deals with a situation that is relatively often and by many experienced in the current world of gainful work: the tension / conflict / ethical challenge that a human can experience and feel in his work in situations of long-term imbalance in realisation its objective and subjective side. A working man can oftentimes perceive this situation as a crisis of ...

  5. Výpočty fázových diagramů multikomponentních soustav Fe-Cr-V-Mo-C-Mn-Ni-Si(-W) a jejich využití

    Czech Academy of Sciences Publication Activity Database

    Unucka, P.; Kroupa, Aleš; Foret, R.; Svoboda, Milan

    2002-01-01

    Roč. 72, č. 279 (2002), s. 145-148 ISSN 1429-6055. [mezinárodní sympozium Struktura a vlastnosti konstrukčních materiálů /16./. Komorní Lhotka, 11.12.2001-13.12.2001] R&D Projects: GA ČR GA106/00/0855 Institutional research plan: CEZ:AV0Z2041904 Keywords : thermodynamic calculations * phase diagrams * steels Subject RIV: BJ - Thermodynamics

  6. Výpočty fázových diagramů multikomponentních soustav Fe-Cr-V-Mo-C-Mn-Ni-Si(-W) a jejich využití

    Czech Academy of Sciences Publication Activity Database

    Unucka, P.; Kroupa, Aleš; Foret, R.; Svoboda, Milan

    2001-01-01

    Roč. 72, - (2001), s. 145-148 ISSN 0137-6969. [Struktura a vlastnosti konstrukčních materiálů. Komorní Lhotka, Opole, 11.12.2001-13.12.2001] R&D Projects: GA ČR GA106/00/0855; GA MŠk OC 522.40 Institutional research plan: CEZ:AV0Z2041904 Keywords : phase equilibria * thermodynamic modelling * steels Subject RIV: BJ - Thermodynamics

  7. The current state of the heaps in Rosicko-Oslavany coal-field and the possibilities of their utilization; Soucasny stav hald v Rosicko-oslavanskem uhelnem reviru a moznosti jejich vyuziti

    Energy Technology Data Exchange (ETDEWEB)

    Svoboda, M. [Univerzita Palackeho v Olomouci, Prirodovedecka fakulta, Katedra rozvojovych studii, 77146 Olomouc (Czech Republic)

    2013-04-16

    The purpose of the article is to assess the importance of heaps for the land Rosicko-Oslavany coal-field. The heap is an anthropogenic land-form resulting from the accumulation of mineral resources extracted from the land. The heap shows as an unusual geomorfophological shape, which does not belong to the environment at first glance. In many respects the heap acts as a barrier for the other development because the heap may contains a dangerous material or may be unstable because of wrong storage of the material. The heaps in studied region stem from the black coal mining. The totals of 11 heaps were discovered during the field reconnaissance. While the heap Jindrich has a good potential for the other use, the heap Kukla represents a burden for its nearest surroundings. (authors)

  8. Frazeologie a idiomatika: Jejich podstata a proměnlivost názorů na ně : Phraseology and Idiomatics: Their Essence and the Changing Views on the Subject

    Directory of Open Access Journals (Sweden)

    František Čermák

    2016-05-01

    Full Text Available The paper addresses most of the current problems in phraseology. General observations on the universal character of idioms and the major aspects of the topic are followed by critical analysis of a prototypical statement about the essential nature of idioms. Much of the analysis centres around the notions of analogy and anomaly. The paper considers the form of the idiom, its analysability, modifiability and metaphoric character, and then challenges the current views on these. Next, the discussion of the idiom and its meaning returns to metaphor and hypothetical decomposition and briefly summarises some of the semantic features of idioms. It suggests that the function of idioms, and the issues of their form and meaning, are best revealed through the character and type of their textual anomalies. The author then presents his views on idioms and their study, referring to analogy and anomaly, regular and irregular language and especially language combinatorics. His approach was tested on data collected for a comprehensive four-volume dictionary of Czech idioms. The paper describes types of combinations and the crucial notions of collocational and virtual paradigms. It offers and exemplifies definitions of idioms and a test for the identification of idioms in text, and a desideratum for further testing of the proposed theory.

  9. Dětská práva a jejich naplňování v životě mentálních jedinců

    OpenAIRE

    CZINEGOVÁ, Eva

    2007-01-01

    A child as every human personality has its worth, dignity and basic rights.Turning-point in the progress of international cooperation and childrens rights protektion became Convention on the Rights of the Child, on 1989. In this essay I tried to find out to what extent mentally handicapped children know their rights, how they understand them, how they use them in their life. I considered publics points of view and extent of awareness of Childrens Rights.I attended also to opinions and experie...

  10. Christoph Landerer, Výuka logiky a psychologie na rakouských gymnáziích: Zimmermann, Lindner a jejich následný vliv - překlad

    Czech Academy of Sciences Publication Activity Database

    Bakešová, Alena

    2009-01-01

    Roč. 57, č. 4 (2009), s. 555-575 ISSN 0015-1831 Institutional research plan: CEZ:AV0Z90090514 Keywords : philosophical propaedeutics * Austrian schooling system * Herbartianism * "crisis of the self" Subject RIV: AA - Philosophy ; Religion

  11. Srovnání sociálních sítí Facebook a Google plus a jejich využití v oblasti marketingu

    OpenAIRE

    Šušič, Luka

    2011-01-01

    The aim of this bachelor thesis is the introduction of social network plus.google.com and its comparison with facebook.com. The second objective is to analyze marketing opportunities of mentioned social networks and marketing on the Internet. This thesis is divided into two parts. The first part is devoted to review and development of social networks, which is focused primarily on Facebook. The main chapter of this section is the introduction of Google + and its comparison with Facebook. The ...

  12. Netradiční oblasti svahových nestabilit v ČR a rozdílný způsob jejich mapování

    Czech Academy of Sciences Publication Activity Database

    Krejčí, O.; Kirchner, Karel

    -, - (2009) [Svahové deformace a pseudokras 2009. 13.05.2009-15.05.2009, Vsetín] Institutional research plan: CEZ:AV0Z30860518 Keywords : slope instabilities * mapping * Czech Republic Subject RIV: DE - Earth Magnetism, Geodesy, Geography

  13. Ovocné náplně a jejich uplatnění v pekárenské výrobě

    OpenAIRE

    Michna, Adam

    2016-01-01

    The thesis discusses the issue of the application of filling in the baking industry. Refills were divided according to durability to durable, medium durable, less durable and fillings for rapid processing. For completeness information about the fillings intended for baking has been added. The work included the characteristics of pastry, which is mostly filled. More attention is paid to fruit fillings, with regard to their growing popularity. The quality of these fillings in recent years has i...

  14. Moderní komunikační a sociální sítě a jejich vliv na chování lidí

    OpenAIRE

    Voroshilova, Ekaterina

    2011-01-01

    Characteristic of social networks, description of their atributes, concept "addiction to social networks", evaluation of marketing in social networks. Analysis of social networks' influence on human behaviour.

  15. Specifika postavení žen na trhu práce v závislosti na délce jejich rodičovské dovolené

    OpenAIRE

    Pochobradská, Kateřina

    2011-01-01

    Bachelor thesis discusses the status of women in the labor market depending on length of their maternity leave. The thesis is divided into two parts, theoretical and practical. The theoretical part focuses on the labor market, family and subsequent harmonization of these two aspects. The practical part consists of research based on real interviews. The obtained data, provided information about the women's strategies before their maternity leave, how they approach self realization, and finally...

  16. K otázce lidských práv tzv. druhé generace a jejich reflex do ústavního práva na lidskou důstojnost

    Czech Academy of Sciences Publication Activity Database

    Güttler, Vojen

    2014-01-01

    Roč. 153, č. 6 (2014), s. 501-511 ISSN 0231-6625 Institutional support: RVO:68378122 Keywords : human rights * social rights * Charter of Fundamental Rights and Freedoms Subject RIV: AG - Legal Sciences

  17. Biofyzikální mechanismy určující biokompatibilitu dentálních implantátů a podmiňující jejich oseointegraci

    Czech Academy of Sciences Publication Activity Database

    Bartáková, S.; Prachár, P.; Hasoň, Stanislav; Silvennoinen, R.; Cvrček, L.; Strašák, Luděk; Fojt, Lukáš; Avranas, A.; Vetterl, Vladimír

    2009-01-01

    Roč. 109, č. 3 (2009), s. 48-53 ISSN 1213-0613 R&D Projects: GA AV ČR(CZ) KAN200040651; GA ČR(CZ) GA202/08/1688 Grant - others:GA MŠk(CZ) 1M0528 Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702 Keywords : titanium dental implants * biocompatibility * oseointegration Subject RIV: BO - Biophysics

  18. Technické obory a jejich začleňování do vznikající Československé akademie věd

    Czech Academy of Sciences Publication Activity Database

    Dvořáčková, Věra

    2017-01-01

    Roč. 9, č. 2 (2017), s. 1-18 ISSN 1803-9448 Institutional support: RVO:67985921 Keywords : Czechoslovak Academy of Sciences, 1950s * scientific and technical development Subject RIV: AB - History OBOR OECD: History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)

  19. Porovnání vývoje způsobů odepisování dlouhodobého majetku a jejich vlivu na daňový základ

    OpenAIRE

    KUBECOVÁ, Jana

    2011-01-01

    The subject of my thesis is "Comparison of development of depreciation methods of long-term assets and their influence on the tax base". The aim of this study was to capture the development of methods of depreciation, amortization of transferring these methods into the numerical expression and assess the impact of the development of depreciation to the tax base. This work does not cover only the current depreciation issues, but focuses on the development of depreciation for the period from 19...

  20. Aromatické nitrosloučeniny ve složkách životního prostředí a jejich vliv na organismy

    OpenAIRE

    Rohlenová, Terezie

    2011-01-01

    Aromatic nitro-compounds are contaminants present in environment. They are produced from gas-phase reaction of their parent compound with oxides of nitrogen. Aromatic nitro-compounds are found in an extract of exhausts from diesel and gasoline engines, in a cigarette smoke and in the soot from burning wood. The most of aromatic nitro-compounds are mutagens in bacterial and mammalian systems and the most of them are carcinogens that are connected with induction of cancer. Primarily lung follow...

  1. Metody zamezení dvojího zdanění a jejich využití v českém daňovém právu

    OpenAIRE

    Turek, Petr

    2015-01-01

    83 RESUMÉ Methods of double taxation avoidance and using thereof in the Czech tax law The Master Thesis deals with the methods of international double taxation avoidance as they are set out by the OECD (Organisation for Economic Co-operation and Development) and UN (United Nations) Model Conventions, as well as by the international bilateral treaties concluded by the Czech Republic based on these model conventions. The definition of the basic terms used by the Czech tax law is first set out b...

  2. Charakterizace produktů spalování paliv a jejich potenciální aplikace v procesu odstraňování polutantů z vodného prostředí

    Czech Academy of Sciences Publication Activity Database

    Ruppenthalová, Lucie; Pavlovský, J.

    2017-01-01

    Roč. 59, č. 1 (2017), s. 9-13 ISSN 1210-7697 R&D Projects: GA MŠk(CZ) LO1406; GA MŠk ED2.1.00/03.0082 Institutional support: RVO:68145535 Keywords : fuel combustion * pollutants * unburned carbon Subject RIV: DH - Mining, incl. Coal Mining OBOR OECD: Materials engineering

  3. Jaderná bezpečnost fúzních elektráren a jejich vliv na životní prostředí.

    Czech Academy of Sciences Publication Activity Database

    Entler, Slavomír; Dostál, V.

    2017-01-01

    Roč. 25, 9-10 (2017), s. 262-268 ISSN 1210-7085 Grant - others:AV ČR(CZ) StrategieAV21/2 Program:StrategieAV Institutional support: RVO:61389021 Keywords : design * reactor safety * thermonuclear fuel s * thermonuclear reactions * thermonuclear reactor materials * thermonuclear reactors * tokamak devices Subject RIV: JF - Nuclear Energetics OBOR OECD: Nuclear related engineering

  4. Pomístní jména a jejich zpracování ve Slovníku pomístních jmen na Moravě a ve Slezsku

    Czech Academy of Sciences Publication Activity Database

    Šipková, Milena

    2010-01-01

    Roč. 51, č. 1 (2010), s. 48-78 ISSN 1211-4413 R&D Projects: GA ČR GA405/08/0703 Institutional research plan: CEZ:AV0Z90610518 Keywords : anoikonyms * dictionary * dialects * onymic maps * anoikonyms area * Dictionary of Moravian and Sikesian anoikonyms / minor place names Subject RIV: AI - Linguistics

  5. Veřejné zakázky z pohledu veřejného zadavatele a jejich finančně-právní aspekty

    OpenAIRE

    Jurošková, Martina

    2012-01-01

    Law on public procurement is very interesting and dynamic part of the Czech law. It is subjected to adjustment in particular Act No. 137/2006 Coll., On Public Procurement, as amended, but is also modified by legislation of the European law. Important are decisions of the European Court of Justice. This thesis entitled "Procurement from the perspective of public authority and their financial and legal aspects" deals with public procurement in particular from the perspective of public authority...

  6. Přírodní drahé kameny a jejich využití ve šperkařství, architektuře a umění

    OpenAIRE

    Jirásek, Jakub; Vavro, Martin; Jiránek, Jaroslav

    2009-01-01

    This paper defines and specifies the groups of natural gemstones. It deals with gemstone classification with emphasis on the chemical mineralogical system of crystals. Gemstone processing is discussed – tumble polishing, facet and flat-surface grinding and polishing, engraving and cutting, plastic grinding, and others. Some examples of natural gemstones used in architecture and art are given. Problems of natural gemstone appraisal are briefly mentioned.

  7. Marketingová komunikace módních značek a jejich vliv na vnímání body image spotřebitele

    OpenAIRE

    Macková, Monika

    2012-01-01

    The Master's Thesis deals with the marketing communication of fashion industry with the focus on two particular global fast fashion brands. The main goal is to identify the specifics of marketing communication strategies of fashion industry, to analyze the approach difference of the two chosen fashion brands H&M and Zara and to define their influence on consumer's body image through qualitative and quantitative research. The thesis is divided into several parts. The first chapter follows up t...

  8. Feromagnetická slitina s tvarovou pamětí Co.sub.38./sub.Ni.sub.33./sub.Al.sub.29./sub. - příprava monokrystalů a jejich charakterizace

    Czech Academy of Sciences Publication Activity Database

    Kopeček, Jaromír; Jurek, Karel; Jarošová, Markéta; Drahokoupil, Jan; Sedláková, Silvia; Šittner, Petr; Novák, Václav

    2009-01-01

    Roč. 16, č. 2 (2009), k27-k28 ISSN 1211-5894 R&D Projects: GA AV ČR(CZ) IAA200100627 Institutional research plan: CEZ:AV0Z10100520; CEZ:AV0Z10100521 Keywords : shape memory alloys * Co-alloys * martensitic transformation * metalography * EBSD Subject RIV: BM - Solid Matter Physics ; Magnetism http://www. xray .cz/ xray /csca/kol2009/abst/kopecek.htm

  9. Problémové rezidenční čtvrti a politiky k jejich regeneraci v postsocialistickém městě – studie Prahy

    Czech Academy of Sciences Publication Activity Database

    Kostelecký, Tomáš; Patočková, Věra; Illner, Michal

    2012-01-01

    Roč. 48, č. 1 (2012), s. 39-63 ISSN 0038-0288 R&D Projects: GA AV ČR IAA700280802 Institutional research plan: CEZ:AV0Z70280505 Keywords : regeneration * residential neighbourhoods * post-socialist city Subject RIV: AD - Politology ; Political Sciences Impact factor: 0.652, year: 2012

  10. Směsné oxidy připravené tepelným rozkladem Co-Mn-Al hydrotalcitů a jejich katalytické vlastnosti

    Czech Academy of Sciences Publication Activity Database

    Kovanda, F.; Rojka, T.; Jirátová, Květa; Obalová, L.; Grygar, Tomáš

    2005-01-01

    Roč. 1, - (2005), s. 81 ISSN 1336-7242. [Zjazd chemických spoločností /57./. 04.09.2005-08.09.2005, Tatranské Matliare] R&D Projects: GA ČR(CZ) GA104/04/2116; GA ČR(CZ) GA106/05/0366 Institutional research plan: CEZ:AV0Z40720504 Keywords : hydrotalcites * layered - double hydroxides * Co-Mn-Al mixed oxides Subject RIV: CF - Physical ; Theoretical Chemistry

  11. Hráči počítačových her a jejich vztahy s rodiči a přáteli

    Czech Academy of Sciences Publication Activity Database

    Vaculík, Martin

    2001-01-01

    Roč. 45, č. 2 (2001), s. 143-151 ISSN 0009-062X R&D Projects: GA ČR GA406/98/1007 Institutional research plan: CEZ:AV0Z7025918 Keywords : parents * peers * computer games Subject RIV: AN - Psychology Impact factor: 0.195, year: 2001

  12. Biologicky aktivní látky imobilizované na magnetických nosičích a jejich využití v biochemii a biotechnologii

    Czech Academy of Sciences Publication Activity Database

    Pečová, M.; Zajoncová, L.; Poláková, K.; Cuda, J.; Šafaříková, Miroslava; Šebela, M.; Šafařík, Ivo

    2011-01-01

    Roč. 105, č. 7 (2011), s. 524-530 ISSN 0009-2770 R&D Projects: GA MŠk(CZ) ED1.1.00/02.0073; GA MPO 2A-1TP1/094 Institutional research plan: CEZ:AV0Z60870520 Keywords : saccharomyces-cerevisiae cells * iron-oxide nanoparticles * alginate microparticles * fluidized-bed * purification * trypsin * microspheres * particles * separations * adsorptions Subject RIV: CE - Biochemistry Impact factor: 0.529, year: 2011

  13. Systémy a projekty e-Customs a jejich implementace v Celní správě ČR

    OpenAIRE

    Harantová, Lenka

    2009-01-01

    Diploma work called "E-customs'systems and projects and their implementation in the Customs administration of the Czech Republic" is intended to provide interested parties with an overview of systems, projects and key issues related to the evolution of the European electronic customs initiative and the present state of play especially in the Czech Customs administration. Subject of e-Customs is a collection of information customs systems and projects in order to exchange data and communicate ...

  14. Sídlištní objekty středního eneolitu z obchvatu Kolína ve světle jejich chronologické a kulturní homogenity

    Czech Academy of Sciences Publication Activity Database

    Dobeš, Miroslav; Šumberová, Radka

    2014-01-01

    Roč. 66, č. 2 (2014), s. 310-346 ISSN 0323-1267 Institutional support: RVO:67985912 Keywords : Bohemia * Kolín * Middle Eneolithic * Řivnáč culture * Bošáca culture * Globular Amphora culture * post-depositional processes Subject RIV: AC - Archeology, Anthropology, Ethnology

  15. Persvazivní techniky v lifestylových časopisech a jejich vliv na formování životního stylu : obsahová analýza časopisu Spy

    OpenAIRE

    Jeřábek, David

    2010-01-01

    Bachelor thesis "Persuasive techniques in lifestyle magazines and their effect on lifestyle-forming : content analysis of Spy magazines" generally deals with media effects on audiences. It introduces the historic development of perspectives on mass media and mass communication and the effects of media and their research. In particular it focuses on the effects of the so-called lifestyle media on the lifestyle and identity of mainly younger consumers of media products. It specifically evaluate...

  16. Konfliktní lekce z internacionalismu. Studenti z „třetího světa“ a jejich konfrontace s českým prostředím (1961-1974)

    Czech Academy of Sciences Publication Activity Database

    Holečková, Marta Edith

    2012-01-01

    Roč. 19, 1-4 (2012), s. 158-175 ISSN 1210-7050 Institutional support: RVO:68378068 Keywords : Univerzita 17. listopadu * students from the ‘Third World’ in Czechoslovakia * "internationalist" propaganda Subject RIV: AJ - Letters, Mass-media, Audiovision

  17. Nakladatelé a jejich dopisy v německojazyčném osvícenství. Komunikační pole autor - nakladatel - vydavatel

    Czech Academy of Sciences Publication Activity Database

    Wögerbauer, Michael

    Roč. 6, č. 2016 (97), s. 97-100 ISSN 1804-6983. [Verleger und ihre Briefe in der deutchsprachigen Aufklärung. Das Kommunikationsfeld Autor - Verleger - Herausgeber. Wittenberg, 01.10.2015-03.10.2015] Institutional support: RVO:68378068 Keywords : conference * enlightenment * book trade Subject RIV: AJ - Letters, Mass-media, Audiovision

  18. Komparace metod odpisování a jejich vliv na základ daně vybrané účetní jednotky

    OpenAIRE

    Rýdlová, Radka

    2015-01-01

    This bachelor thesis deals with the issues of account and tax depreciation long-term material property according to regulations valid in the Czech Republic. In literary research of this thesis, there is long-term material property specified, ways of its obtaining and valuation, methods of depreciation according to tax and account point of view. Own work is oriented on calculation depreciation specified property of the company TS Ledeč nad Sázavou Inc. and review impact of depreciation on tax ...

  19. Několik náhodných nálezů z Libice nad Cidlinou a jejich význam pro poznání dálkových kontaktů

    Czech Academy of Sciences Publication Activity Database

    Profantová, Naďa

    2012-01-01

    Roč. 66, 1-2 (2012), s. 55-62 ISSN 0036-5335 Institutional research plan: CEZ:AV0Z80020508 Keywords : Early Middle Ages * stronghold * metal artefacts Subject RIV: AC - Archeology, Anthropology, Ethnology

  20. Příprava těstovin s různým podílem merlíkové mouky a jejich kvalitativní hodnocení

    OpenAIRE

    BIGASOVÁ, Věra

    2014-01-01

    Quinoa (Chenopodium quinoa) is a very nutritionally valuable crop with versatility. The aim of this work was a practical experiment to test the possibility of pasta production with different proportions of quinoa flour and evaluate their selected qualitative properties. The thesis includes also photos of pasta production and the results of questionnaires summarizing the views of consumers on pasta containing quinoa flour. We can advise to use of quinoa flour up to 30% share for the production...

  1. Rozvoj plastických deformací v oceli při konstantním zatížení a jejich význam pro plynárenskou praxi

    Czech Academy of Sciences Publication Activity Database

    Gajdoš, Lubomír; Šperl, Martin; Pařízek, P.

    2013-01-01

    Roč. 93, č. 9 (2013), s. 198-203 ISSN 0032-1761 R&D Projects: GA ČR(CZ) GAP105/10/2052 Institutional support: RVO:68378297 Keywords : low-temperature creep * deformation * pipe Subject RIV: JL - Materials Fatigue, Friction Mechanics

  2. Extracelulární váčky II. Exozomy a jejich význam u patofyziologických stavů člověka

    Czech Academy of Sciences Publication Activity Database

    Kupcová Skalníková, Helena; Kovářová, Hana

    2017-01-01

    Roč. 2017, č. 1 (2017), s. 4-7 ISSN 0044-4812 R&D Projects: GA MŠk(CZ) LO1609 Institutional support: RVO:67985904 Keywords : extracellular vesicles Subject RIV: EB - Genetics ; Molecular Biology OBOR OECD: Biochemistry and molecular biology

  3. Expozice komunitnímu násilí a školní šikana a jejich vztah k antisociálnímu chování v rané adolescenci

    Czech Academy of Sciences Publication Activity Database

    Sobotková, Veronika; Osecká, Terezie; Jelínek, Martin; Blatný, Marek; Hrdlička, M.

    2012-01-01

    Roč. 56, č. 5 (2012), s. 409-419 ISSN 0009-062X Institutional research plan: CEZ:AV0Z7025918 Keywords : antisocial behavior * exposure to violence * school bullying Subject RIV: AN - Psychology Impact factor: 0.244, year: 2012

  4. Odcházení: Političky odcházející z politické scény a jejich zkušenosti

    Czech Academy of Sciences Publication Activity Database

    Rakušanová, Petra; Václavíková-Helšusová, L.

    2008-01-01

    Roč. 9, č. 1 (2008), s. 16-25 ISSN 1213-0028 R&D Projects: GA AV ČR 1QS700280503 Institutional research plan: CEZ:AV0Z70280505 Keywords : female political participation * quality of democracy * female political carrier Subject RIV: AO - Sociology, Demography http://dlib.lib.cas.cz/3008/

  5. Daňové ráje a způsoby jejich využití v mezinárodním daňovém plánování

    OpenAIRE

    Martínek, Ondřej

    2012-01-01

    Diplomová práce Ondřej Martínek Abstract Tax havens are thorn in the eye of the OECD countries, nonetheless they emerged originally on europian soil and on the ruins of british empire. Classical accusation argues, the tax havens are supposed to earn on luring foreign capital that is enabled to evade taxation and by that they breach the balance of national budgets and tax justice in developed countries, enwiden social imbalance and speed up global tax competition. There are many forms of tax a...

  6. O ČEZu, UNESCU a Ikee. Psaní iniciálových zkratkových slov a tendence k jejich skloňování

    Czech Academy of Sciences Publication Activity Database

    Dufek, Ondřej

    2016-01-01

    Roč. 99, č. 5 (2016), s. 256-268 ISSN 0027-8203 R&D Projects: GA MŠk(CZ) LM2010013 Institutional support: RVO:68378092 Keywords : initialism * acronym * declension * orthography Subject RIV: AI - Linguistics

  7. Trendy v problematice panelových sídlišť s důrazem na filozofii jejich regenerace ů s příklady z České republiky

    Czech Academy of Sciences Publication Activity Database

    Kallabová, Eva

    2002-01-01

    Roč. 10, č. 1 (2002), s. 26-31 ISSN 1210-8812 R&D Projects: GA AV ČR KSK3046108 Keywords : prafab housing estates * humanization * regeneration Subject RIV: DE - Earth Magnetism, Geodesy, Geography

  8. Čisté mlékařské kultury a jejich využití v potravinářství

    OpenAIRE

    Urbanová, Iveta

    2015-01-01

    The aim of the bachelor thesis is characterization of dairy starter cultures and their use for fermented milk products, cheese production, fermented sausages, fermented vegetables, fermented beverages and other fermented foods. These starters are commonly used in milk processing, therefore there are basic milk requirements listed in this thesis. The thesis is emphasising the particular culture types, their parameters and individual microorganisms in starter cultures. Subsequently this thesis ...

  9. Herramientas no invasivas en Venezuela: comparación entre las pruebas inmunoserológicas DAT, rK26 y rK39 en el diagnóstico de leishmaniasis visceral

    NARCIS (Netherlands)

    Terán-Ángel, Guillermo; Rodríguez, Vestalia; Silva, Rosilved; Zerpa, Olga; Schallig, Henk; Ulrich, Marian; Cabrera, Maira

    2010-01-01

    Human visceral leishmaniasis is a serious public health problem in endemic countries because of its high potential lethality, particularly in children. Rapid diagnosis is essential to early treatment and control of visceral leishmaniasis. The aim was to compare three serodiagnostic tools for human

  10. Interaktivní reprodukce výsledků sčítání lidu pomocí statistického modelu se zaručenou ochranou anonymity dat

    Czech Academy of Sciences Publication Activity Database

    Grim, Jiří; Hora, J.; Pudil, Pavel

    2004-01-01

    Roč. 40, č. 5 (2004), s. 400-414 ISSN 0322-788X R&D Projects: GA ČR GA402/02/1271 EU Projects: European Commission(XE) 507752 - MUSCLE Institutional research plan: CEZ:AV0Z1075907 Keywords : probabilistic models * finite mixtures * statistical disclosure control Subject RIV: AE - Management ; Administration

  11. Bepaling ongevalsrisico van de elektrisch ondersteunde fiets : een inschatting van het `eigen' ongevalsrisico en dat voor andere weggebruikers. In opdracht van het Directoraat-Generaal Rijkswaterstaat, Adviesdienst Verkeer en Vervoer AVV.

    NARCIS (Netherlands)

    Schoon, C.C.

    1999-01-01

    The electrically driven bicycle is equipped with an auxiliary-engine that is switched on when a certain pedalling power is applied. The legal position of this type of bicycle in the Netherlands is, at this moment in time, dual. According to the Road Traffic Act, it is a `normal' bicycle for which

  12. Analýza trhu kávy v České republice a na Slovensku na základě dat z maloobchodního auditu

    OpenAIRE

    Kolářová, Zuzana

    2017-01-01

    The aim of the diploma thesis is a comprehensive analysis of the coffee market in the Czech Republic and Slovakia based on retail audit data. The analysis provides an overview of the development of this dynamic category. It also compares the similarities and differences in both countries. I proceed from the historical development of the market to the current situation in terms of its size, market trends and structure. I also focus on the promotion importance of the coffee category and the sea...

  13. Projekt ArcLib - budování systému pro dlouhodobou archivaci digitálních dat v českých knihovnách

    Czech Academy of Sciences Publication Activity Database

    Melichar, M.; Hutař, J.; Růžička, M.; Hruška, Z.; Vašek, Z.; Bartošek, M.; Lhoták, Martin

    2016-01-01

    Roč. 20, č. 2 (2016), s. 13-17 ISSN 1335-793X R&D Projects: GA MK(CZ) DG16P02R044 Keywords : digital archiving * open source * OAIS Subject RIV: IN - Informatics, Computer Science http://itlib.cvtisr.sk/buxus/docs/13_projekt%20arclib.pdf

  14. Analýza zabezpečení přenosu dat na různých vrstvách referenčního modelu OSI

    OpenAIRE

    Kňazovický, Pavel

    2009-01-01

    Táto práca sa zaoberá analýzou protokolov zaisťujúcich zabezpečený prenos dát. V prvej časti je stručne popísaný referenčný model ISO/OSI. Druhá časť je zameraná na samotné zabezpečené protokoly na jednotlivých vrstvách ISO/OSI modelu, z ktorých je v tretej časti podrobne analyzovaný protokol SSL/TLS. Posledná časť sa venuje často používaným útokom v oblasti počítačových sietí a ich služieb, kde je uvedená aj základná prevencia proti nim. The aim of this Bachelor's thesis is the analysis o...

  15. Serological survey of Leishmania infection in dogs from the municipality of Peso da Régua (Alto Douro, Portugal) using the direct agglutination test (DAT) and fast agglutination screening test (FAST)

    NARCIS (Netherlands)

    Cardoso, Luís; Schallig, Henk D. F. H.; Neto, Francisco; Kroon, Nel; Rodrigues, Manuela

    2004-01-01

    Leishmaniasis caused by Leishmania infantum is a prevalent disease in dogs and humans. A serological survey of Leishmania infection in dogs was carried out in the endemic region of Alto Douro (north Portugal). Two hundred and ninety-four dogs from the municipality of Peso da Régua were examined for

  16. Problematika vytváření relačních dat: příklad analýzy sociálních sítí bezdomovců

    Directory of Open Access Journals (Sweden)

    Laco Toušek

    2009-12-01

    Full Text Available The paper considers problems with data collection methods for social network analysis specifically so called name generators that are widely used in surveys and interviews. The issue is exampled by a research of homeless people in Pilsen, Czech Republic. Beginning with the general discussion of relational data and basic network terms, the article then covers methods of data collection with focus on name generators. A description of non-representative research design on social support networks of homeless people follows. The selected results show that personal networks are small, with high density and rather based on kin or friendship ties. Further, major parts of the ties are outside the homelessness. However, the ecological validity of the results is questioned. On the basis of the triangulation with a data from the qualitative interviews the paper concludes that the personal networks are rather “cognitive networks” than the actual social relations.

  17. VYUŽITÍ DAT Z METEOROLOGICKÉ GEOSTACIONÁRNÍ DRUŽICE METEOSAT SECOND GENERATION K ODHADU SRÁŽEK ZE SILNÝCH KONVEKTIVNÍCH BOUŘÍ

    Czech Academy of Sciences Publication Activity Database

    Bližňák, Vojtěch; Sokol, Zbyněk

    2011-01-01

    Roč. 64, č. 2 (2011), s. 43-51 ISSN 0026-1173 R&D Projects: GA ČR GA205/07/0905 Institutional research plan: CEZ:AV0Z30420517 Keywords : convective rainfalls * meteorological satellite * weather radar * Czech Republic Subject RIV: DG - Athmosphere Sciences, Meteorology

  18. Využití družicových radarových dat pro monitorování záplav v závislosti na typu krajinného pokryvu

    OpenAIRE

    Rauch, Tomáš

    2011-01-01

    The aim of this thesis is to find method for flood monitoring from radar images. The thesis deals with flood in general and with organization of flood protection. There are described principles of radar sensors. There is also summary of satellites with their parameters. Next part of the thesis describes interaction between radar beam and different types of surface. Theoretical part is closed by overview of the existing methods for flood monitoring. In the practical part there is method for fl...

  19. Srovnání některých dat registru alert-cz s daty dřívějšího pilotního registru akutního infarktu myokardu

    Czech Academy of Sciences Publication Activity Database

    Peleška, Jan; Reissigová, Jindra; Tomečková, Marie; Grünfeldová, H.; Janský, P.; Monhart, Z.; Vojáček, J.; Widimský, J.; Zvárová, Jana

    2010-01-01

    Roč. 52, Suppl. 1 - CD ROM (2010), A248 ISSN 0010-8650. [Výroční sjezd České kardiologické společnosti /18./. 16.05.2010-19.05.2010, Brno] R&D Projects: GA MŠk(CZ) 1M06014 Institutional research plan: CEZ:AV0Z10300504 Keywords : registr akutního infarktu myokardu * rizikové faktory infarktu myokardu * PCI a akutní farmakoterapie infarktu myokardu Subject RIV: IN - Informatics, Computer Science

  20. Projekty pro sdílení dat na internetu typu Rapidshare se zaměřením na konkrétní vybraný projekt a jeho rozbor

    OpenAIRE

    Hřebabecký, Jan

    2010-01-01

    The goal of the thesis is to analyse and coherently describe a branch that haven't been sufficiently described in professional literature yet. To reach this goal thesis uses author's experience with specific share server development and operation and puts it as an example on which it explains all the important attributes and dependencies. Diploma thesis is aimed to an issue of internet file sharing. In it's first part it describes file sharing in general including history of internet file sha...

  1. De democratische kwaliteit van gemeenteraadsverkiezingen’

    NARCIS (Netherlands)

    Boogers, Marcel; Reynaert, Herwig

    2018-01-01

    Gemeenteraadsverkiezingen horen ertoe bij te dragen dat het lokale beleid overeenkomt met de beleidsvoorkeuren van inwoners. Dat is immers de democratische functie van verkiezingen. De gedachte hierachter is dat als kiezers zich uitspreken over de beleidsprestaties en verkiezingsbeloften van

  2. Nederlands pensioenstelsel verre van af

    NARCIS (Netherlands)

    Boot, A.

    2008-01-01

    Het Nederlandse pensioenstelsel wordt verblijd met een nieuw type pensioeninstelling, de API (Algemene Pensioeninstelling). In optimale vrijheid moet deze kunnen functioneren met een toezichtregime dat aansluit op zowel dat van verzekeraars als dat van pensioenfondsen. Het pensioenstelsel is daarmee

  3. Regulation of dopamine transporter activity by carboxypeptidase E

    Directory of Open Access Journals (Sweden)

    Zhang Heping

    2009-05-01

    Full Text Available Abstract Background The dopamine transporter (DAT plays a critical role in terminating the action of dopamine by rapid reuptake into the presynaptic neuron. Previous studies have revealed that the DAT carboxyl terminus (DAT-CT can directly interact with other cellular proteins and regulate DAT function and trafficking. Results Here, we have identified that carboxypeptidase E (CPE, a prohormone processing exopeptidase and sorting receptor for the regulated secretory pathway, interacts with the DAT-CT and affects DAT function. Mammalian cell lines coexpressing CPE and DAT exhibited increased DAT-mediated dopamine uptake activity compared to cells expressing DAT alone. Moreover, coexpression of an interfering DAT-CT minigene inhibited the effects of CPE on DAT. Functional changes caused by CPE could be attributed to enhanced DAT expression and subsequent increase in DAT cell surface localization, due to decreased DAT degradation. In addition, CPE association could reduce the phosphorylation state of DAT on serine residues, potentially leading to reduced internalization, thus stabilizing plasmalemmal DAT localization. Conclusion Taken together, our results reveal a novel role for CPE in the regulation of DAT trafficking and DAT-mediated DA uptake, which may provide a novel target in the treatment of dopamine-governed diseases such as drug addiction and obesity.

  4. De moeder mag zeggen waar ze haar baby krijgt

    NARCIS (Netherlands)

    Kingma, E.M.

    2012-01-01

    Soms nemen aanstaande moeders beslissingen die niet in het belang van hun aanstaande kind lijken te zijn. Zoals thuis willen bevallen bij een stuitligging of een tweeling. Mag dat? Ja, dat mag. Zelfs als dat betekent dat de aanstaande baby een groot risico loopt om dood te gaan of blijvende schade

  5. The invasion of Iraq: a challenge to the Charter Prohibition of ...

    African Journals Online (AJOL)

    As 'n rede vir die inval is aangevoer dat Irak oor wapens van massavernietiging beskik wat 'n gevaar vir die wereld daarstel, en dat dit daarom noodsaaklik was om Irak militer te oorweldig en te ontwapen. Daar is ook daarop gesteun dat President Saddam Hussein 'n roekelose diktator is, en dat 'n regimeverandering tot ...

  6. Postendocytic sorting of constitutively internalized dopamine transporter in cell lines and dopaminergic neurons

    DEFF Research Database (Denmark)

    Eriksen, Jacob; Bjørn-Yoshimoto, Walden Emil; Jørgensen, Trine Nygaard

    2010-01-01

    The dopamine transporter (DAT) mediates reuptake of released dopamine and is the target for psychostimulants, such as cocaine and amphetamine. DAT undergoes marked constitutive endocytosis, but little is known about the fate and sorting of the endocytosed transporter. To study DAT sorting in cells...... lines, we fused the one-transmembrane segment protein Tac to DAT, thereby generating a transporter (TacDAT) with an extracellular antibody epitope suited for trafficking studies. TacDAT was functional and endocytosed constitutively in HEK293 cells. According to an ELISA-based assay, TacDAT intracellular...

  7. Regulation of dopamine transporter trafficking by intracellular amphetamine

    DEFF Research Database (Denmark)

    Kahlig, Kristopher M; Lute, Brandon J; Wei, Yuqiang

    2006-01-01

    -induced cell surface DAT redistribution may result in long-lasting changes in DA homeostasis. The molecular mechanism by which AMPH induces trafficking is not clear. Because AMPH is a substrate, we do not know whether extracellular AMPH stimulates trafficking through its interaction with DAT and subsequent...... alteration in DAT function, thereby triggering intracellular signaling or whether AMPH must be transported and then act intracellularly. In agreement with our previous studies, extracellular AMPH caused cytosolic redistribution of the wild-type human DAT (WT-hDAT). However, AMPH did not induce cytosolic...... redistribution in an uptake-impaired hDAT (Y335A-hDAT) that still binds AMPH. The divalent cation zinc (Zn(2+)) inhibits WT-hDAT activity, but it restores Y335A-hDAT uptake. Coadministration of Zn(2+) and AMPH consistently reduced WT-hDAT trafficking but stimulated cytosolic redistribution of Y335A...

  8. Udržitelný rozvoj a genderové nerovnosti. Zpráva z konference Ženy jako aktérky udržitelného rozvoje

    Czech Academy of Sciences Publication Activity Database

    Marková Volejníčková, Romana; Pospíšilová, Marie

    2017-01-01

    Roč. 18, č. 1 (2017), s. 221-224 ISSN 2570-6578 Institutional support: RVO:68378025 Keywords : sustainable development * gender * globalization Subject RIV: AO - Sociology, Demography http://www.genderonline.cz/cs/issue/42-rocnik-18-cislo-1-2017-gender-na-neoliberalni-univerzite-transnacionalni-procesy-a-jejich-lokalni-dopady/517

  9. The Neoliberal/ising University at the Intersection of Gender and Place

    Czech Academy of Sciences Publication Activity Database

    Nyklová, Blanka; Riegraf, B.; Aavik, K.

    2017-01-01

    Roč. 18, č. 1 (2017), s. 2-8 ISSN 2570-6578 Institutional support: RVO:68378025 Keywords : neoliberal university * geopolitics * neoliberalism Subject RIV: AO - Sociology, Demography http://www.genderonline.cz/cs/issue/42-rocnik-18-cislo-1-2017-gender-na-neoliberalni-univerzite-transnacionalni-procesy-a-jejich-lokalni-dopady/519

  10. The power of personality in discriminating between healthy aging and early-stage Alzheimer's disease.

    Science.gov (United States)

    Duchek, Janet M; Balota, David A; Storandt, Martha; Larsen, Randy

    2007-11-01

    This study examined differences in personality in the earliest stages of dementia of the Alzheimer type (DAT) relative to healthy aging, and the power of personality in discriminating healthy aging from early-stage DAT. Four groups of participants (middle-aged controls, older controls, persons with very mild DAT, and persons with mild DAT) and their families were administered Costa and McCrae's NEO Five-Factor Inventory. On the basis of both self-report and informant report, there was an increase in neuroticism and a decrease in conscientiousness in persons with very mild DAT relative to healthy individuals without it, and in persons with mild DAT relative to those with very mild DAT. Moreover, informant reports of neuroticism and conscientiousness capture substantial unique variance in discriminating healthy aging and very mild DAT, above and beyond standard neuropsychological tests. Discussion focuses on the importance of personality traits as a noncognitive indicator of early-stage DAT.

  11. Purists, Partisans, and the Aesthetic Dimension of Sport

    Directory of Open Access Journals (Sweden)

    Charles Robinson

    2014-05-01

    Full Text Available Purists, Partisans, and the Aesthetic Dimension of Sport Stephen Mumford, in his book Watching Sport, identifies two types of sports spectator – partisans and purists. Partisans are more concerned to see their team win, whether they do so in an aesthetically pleasing way or not, while purists have no such irrational commitment, and instead pursues the higher aesthetic experience of sport. The purist, Mumford argues, is superior because she watches sport for aesthetic and intellectual reasons and sees the game, it seems, more objectively, whereas the partisan is emotional and victoryseeking, experiencing the game through the lens of their desire for victory. But this distinction, I argue, doesn’t do justice to the actual experience of spectators. Whilst Mumford is correct to suggest that the aesthetic dimension is vital in our enjoyment of sport, there is no reason to suppose that the partisan cannot partake in the aesthetic appreciation of sport. Furthermore, whilst winning is obviously hugely important in judging the quality of sports teams, they are likely to be more fondly regarded if they do so through the demonstration of virtues that are aesthetic in nature. Even the most vociferous of partisans are capable of appreciating such teams. Puristé, partyzáni a estetická dimenze sportu Ve své knize Watching Sport Stephen Mumford identifikuje dva typy sportovních diváků – partyzány a puristy. Partyzáni se zajímají spíše o výhru svého týmu, ať už je jejich hra estetická, nebo ne, zatímco puristé nemají tento iracionální zájem a zajímá je vyšší estetický sportovní zážitek. Mumford považuje puristy za nadřazenější, protože sledují sport z estetických a intelektuálních důvodů, a zdá se, že vidí hru objektivněji, zatímco partyzáni jsou emocionální a sledují hru skrze touhu po vítězství. Moje argumenty ukazují, že toto pojetí adekvátně nepopisuje zážitek diváků. Zatímco Mumford

  12. Ochrana lignocelulózových materiálů aplikací par esenciálních olejů – posouzení vlivů těchto látek na jejich vlastnosti

    Czech Academy of Sciences Publication Activity Database

    Gojný, J.; Češek, B.; Mikala, O.; Milichovský, M.; Křůmal, Kamil; Večeřa, Zbyněk

    2014-01-01

    Roč. 69, 3-4 (2014), s. 93-97 ISSN 0031-1421 R&D Projects: GA MK DF11P01OVV028 Keywords : mechanical properties * optical properties * essential oils Subject RIV: CB - Analytical Chemistry, Separation

  13. Postoje studentů sportovní výchovy ke sportovní aktivitě nevidomých v Maďarsku a jejich možné příčiny Attitudes of students in sport education to the sport activity of blind people in Hungary and possible reasons for them

    Directory of Open Access Journals (Sweden)

    Gábor Ramocsa

    2007-02-01

    Full Text Available Velmi nízká účast nevidomých na sportovních aktivitách je způsobena především nedostatečnými znalostmi odborníků v oblasti sportu pro postižené osoby. Sportovní trenéři a 582 budoucí učitelé tělesné výchovy byli dotazováni na znalosti a představy o sportovních aktivitách osob s postižením, především nevidomých. Průzkum prokázal, že učitelům tělesné výchovy a trenérům, kteří se účastní sportovních aktivit určených pro postižené, dobré úmysly v zásadě neschází a že hlavní překážkou je nedostatek témat týkajících se sportu pro postižené v osnovách studijních oborů. Janečka, Kudláček a Válková (2003 zdůraznili zásadní potřebu speciálně připravených učitelů tělesné výchovy, a to především na základních školách. Osobní zkušenosti a přímý kontakt s nevidomými sportovci nemohou být nahrazeny audiovizuálními vzdělávacími metodami. Nevidomí se nemohou v důsledku svého postižení stát trenéry, takže sport pro nevidomé musí být rozvíjen s aktivní podporou a spoluprací se sportovními odborníky bez zrakového postižení. Sport pro postižené musí být vyučován jako samostatný předmět nebo alespoň jako samostatný a zdůrazňovaný úsek již stávajícího běžného předmětu, jako je teorie tréninku. Z metodického hlediska je zásadní a nenahraditelný osobní kontakt s nevidomými a také praktická setkání v průběhu výchovy (Asjborn & Tonjum, 1986. Studenti by neměli školu opouštět bez specifických znalostí o sportu pro postižené a o možných způsobech zapojení nevidomých do sportovních aktivit. Takový mnohostranný přístup ke vzdělávání je budoucí a moderní metodou výuky. The very low participation of blind people in sport is fundamentally caused by the inappropriate knowledge of experts on disabled – specific areas of sport. Sport coaches and 582 students learning to be PE teachers were asked about their knowledge and ideas of sport for individuals with disabilities, mainly for blind people. Research has proved that good intentions of PE teachers and coaches taking part in disabled sport are basically not missing, thus the main barrier is the lack of topics regarding sport for handicapped people in the curriculum of their studies. Janečka, Kudláček and Válková (2003 have emphasized the basic need of specially prepared PE teachers, mainly in the elementary schools. Personal experience and direct contact with blind athletes cannot be replaced by audiovisual methods of education. Blind people cannot be trained to be coaches by the nature of their disability, so blind sport must be developed through the active support and cooperation of sighted sport experts. Sport for the disabled has to be taught as a separate subject, or at least as a separate and stressed section of an already existing, regular subject, such as theory of training. Methodically, personal contact with blind people as well as practical sessions in the course of their education is essential and irreplaceable (Asjborn & Tonjum, 1986. Students should not be allowed to graduate without specific knowledge about sport for the handicapped, and about the possible ways for participation in sport for blind athletes. Such a many sided approach of education is the future and the modern way of teaching.

  14. Poznámky k lexikálním výpůjčkám ve staroslověnštině a jejich reflexe v češtině a ostatních slovanských jazycích (sémanticko-etymologická analýza)

    Czech Academy of Sciences Publication Activity Database

    Karlíková, Helena

    2013-01-01

    Roč. 82, č. 1/2 (2013), s. 158-168 ISSN 0037-6736. [Mezinárodní sjezd slavistů /15./. Minsk, 20.08.2013-27.08.2013] R&D Projects: GA ČR GA13-17435S Institutional support: RVO:68378092 Keywords : Old Church Slavonic * lexical loan-words * etymology * Slavonic languages Subject RIV: AI - Linguistics

  15. Pojmenování barev a jejich odstínů v Akademickém slovníku současné češtiny : Names of Colours and Colour Shades in the Academic Dictionary of Contemporary Czech

    Directory of Open Access Journals (Sweden)

    Lišková, Michaela

    2015-10-01

    Full Text Available The paper deals with processing the entries describing colours in the Academic Dictionary of Contemporary Czech (ASSČ, the priority being the explanation of basic meanings of primary colours and lexicalised colour shades. The definitions ought to include all semantic features, be clear and should reflect the present world and the experience of the user. Special attention is given to the explanations of adverbs and compound adjectives. The paper also follows the decision-making process leading to the list of entries within a given category, based on the frequency of the lemma in the SYN corpus, and discusses the problem of appropriate exemplification.

  16. Středověké plužiny Velké Británie a jejich význam pro poznání zemědělského vývoje v českých zemích

    Czech Academy of Sciences Publication Activity Database

    Dohnal, Martin

    2011-01-01

    Roč. 98, č. 4 (2011), s. 337-357 ISSN 0009-0794 R&D Projects: GA ČR(CZ) GAP410/11/1287 Keywords : landscape * historical geography * England * middle ages and early modern period * land use * agriculture * ridge and furrow Subject RIV: AC - Archeology, Anthropology, Ethnology Impact factor: 0.094, year: 2011

  17. Způsoby hlasování ve volbách a jejich historický vývoj: hlasovací technika jako stěžejní proměnná volebního procesu

    Directory of Open Access Journals (Sweden)

    Sylvie Reterová

    2007-08-01

    Full Text Available This paper examines the issue of ballot voting in elections with a focus on traditional and modern voting methods. The purpose is to provide policy analysis with a survey of the development of voting methods, from their earliest form up to contemporary democratic technologies. The study offers a systematic evaluation of the voting mechanism, especially the paper ballot, machine voting, punchcard voting, optical mark-sense voting and electronic voting. On the basis of case studies, their impact on electoral process and the accuracy of election results is evaluated, as well as their impact on the quality of democracy. The accent is put on voting procedures which are user-friendly and trustworthy at the same time.

  18. Nadpřirozené bytosti v knihách o Harry Potterovi a jejich srovnání s pohádkovými příběhy/Supernatural Creatures in the Harry Potter Series and Their Comparison with Fairy Tale Stories

    OpenAIRE

    JEŘÁBKOVÁ, Vanda

    2013-01-01

    This bachelor thesis deals with selected supernatural creatures of Harry Potter?s series. It is primarily focused on a dragon, basilisk, phoenix, unicorn, merpeople, werewolf, giant and wizard. Each of these creatures is depicted from author?s point of view at first, then it is compared with its original depiction and finally it draws a comparison between itself and its fairy tale?s portrayal. The emphasis is put on comprehension of the chosen creature?s main meaning, its role and functioning...

  19. Příprava funkcionalizovaných nanočástic a studum jejich uspořádání, spektrálních vlastností a schopnosti přenášet náboj

    Czech Academy of Sciences Publication Activity Database

    Janoušek, Jiří; Bělohradský, Martin; Hadravová, Romana; Matějka, P.; Matějková, Stanislava; Prokopec, V.; Rybáček, Jiří; Stará, Irena G.; Starý, Ivo

    2016-01-01

    Roč. 14, č. 2 (2016), s. 68 ISSN 2336-7202. [Mezioborové setkání mladých biologů, biochemiků a chemiků /16./. 10.05.2016-13.05.2016, Milovy] R&D Projects: GA ČR(CZ) GA16-08327S Institutional support: RVO:61388963 Keywords : gold nanoparticles * molecular electronics * spectral study Subject RIV: CC - Organic Chemistry

  20. Duchovní cvičení sv. Ignáce z Loyoly a jejich vhodnost pro uskutečnění pastoračních cíů II. Vatikánského koncilu

    OpenAIRE

    Martvoň, Miroslav

    2008-01-01

    Anglická anotácia Spiritual Exercises of saint Ignatius of Loyola and its suitability for reaching of pastoral aims of 2nd Vatican Council. On the one hand the paper presents an description of the Spiritual Exercises, its methodology and is focused on its aims; on the other hand paper presents very basic, fundamental aims of 2nd Vatican Council, the aims of every document and in a result there is comparison of the aims for evidence how can Spiritual Exercises of Ignatius of Loyola help to ach...

  1. Péče o zaměstnance na mateřské a rodičovské dovolené a jejich podpora při návratu a slaďování soukromého a pracovního života

    OpenAIRE

    Šádová, Kateřina

    2015-01-01

    This bachelor thesis is focused on family policies concerning employees on maternity and parental leave. It analyses the employment of parents, child care institutions and the use of alternative jobs. The thesis mentions best practices of family policies in Slovakia, Poland, Germany, Sweden, Norway, Denmark and Finland. The thesis also includes a case study in the organization focused on the approach of this organization to employees on maternity and parental leave and particular tools used i...

  2. Provozní podmínky strojů, jejich údržba, efektivita a analýza oprav se zaměřením na provoz balících strojů

    OpenAIRE

    HRON, Milan

    2013-01-01

    Introduction of the Bachelor work includes basic concept about technical documentation, main structure and meaning. Application of technical documentation is presented on the packaging machine Multivac R 240. The practical part of the work consists of the state of technical documentation of the packaging machine and at the same time is suggested solution for optimization of technical state of the machine. The practical part deals with the technical state of the machine, maintenance, analysis,...

  3. Zúčtovací vztahy se zaměřením na dodavatelsko odběratelské vztahy a jejich zachycení v účetnictví konkrétní účetní jednotky

    OpenAIRE

    PEŠOVÁ, Eva

    2009-01-01

    The main goal of this thesis was to sum up the dilema of active debts and engagements from the view of suppliers and customers relationships and to bring closer accounting in a specific company which works on the field of producing and selling plastics products. In my thesis I focused on specific accountig of active debts for subscribers, engagements against suppliers, provided and recived advance payments, accounting of exchange rate difference and time resolution. I have also investigated i...

  4. Porovnání frekvencí mikrojader u matek a jejich novorozenců z oblastí s různým typem znečištění ovzduší

    Czech Academy of Sciences Publication Activity Database

    Rössnerová, Andrea; Špátová, Milada; Pastorková, Anna; Tabashidze, Nana; Veleminský Jr., M.; Balaščak, I.; Solanský, I.; Šrám, Radim

    -, 5-6 (2011), s. 56-63 ISSN 1211-0337 R&D Projects: GA MŽP(CZ) SP/1B3/8/08; GA MŽP(CZ) SP/1B3/50/07; GA MŠk 2B06088 Institutional research plan: CEZ:AV0Z50390703 Keywords : air pollution * mothers-newborns * c-PAHs Subject RIV: DN - Health Impact of the Environment Quality

  5. Přesídlování Čechů, Slováků, Poláků a Němců z bývalého Sovětského svazu do vlasti jejich předků

    Czech Academy of Sciences Publication Activity Database

    Valášková, Naďa; Pojarová, Tereza

    2009-01-01

    Roč. 96, č. 3 (2009), s. 225-245 ISSN 0009-0794 R&D Projects: GA AV ČR IAA700580801 Institutional research plan: CEZ:AV0Z90580513 Keywords : migration * resettlement * countrymen Subject RIV: AC - Archeology, Anthropology, Ethnology

  6. Environmentální výchova a vzdělávání na základních školách, ve školních družinách a jejich vzdělávacích programech

    OpenAIRE

    SCHÖNBEKOVÁ, Hana

    2013-01-01

    Bachelor thesis deals with environmental education and edification in the Czech Republic. Characterizes the issue of terminology and summarizes the legislative and curriuclar documents relating to this topic. Specifically, it focuses mainly on the environmental education and edification that are included in the school education programmes. On the examples of three elementary schools and their after-schools childcare show ways to environmental education and edification into education programme...

  7. Dřevěný meč ze Čáslavi. Nálezy dřevěných předmětů podobných chladným zbraním a jejich interpretace

    Czech Academy of Sciences Publication Activity Database

    Tomášek, Martin

    2005-01-01

    Roč. 57, č. 3 (2005), s. 561-572 ISSN 0323-1267 Institutional research plan: CEZ:AV0Z80020508 Keywords : archeology * material culture * wooden sword Subject RIV: AC - Archeology, Anthropology, Ethnology

  8. Uplatnění regionálních potravin ve veřejných stravovacích zařízeních a jejich význam při rozvoji cestovního ruchu

    OpenAIRE

    STEHLÍKOVÁ, Jaroslava

    2016-01-01

    The thesis deals with the application of regional foods, their use in gastronomic restaurants and their share of the importance of tourism. Major emphasis is placed on research into how big motivation users of dining restaurants and whether the current menu includes traditional regional foods and local culinary specialities. The theoretical part is introduced such as gastronomy and tourism related issues. It is also presented as an example of individual projects, which are implemented in the ...

  9. Myšlení a netechnický přístup k věcem, jejich chránění a ohleduplné (básnické) zacházení s nimi

    Czech Academy of Sciences Publication Activity Database

    Olšovský, Jiří

    2013-01-01

    Roč. 8, č. 3 (2013), s. 1-13 ISSN 1802-3061 Institutional support: RVO:67985955 Keywords : enframement * technology * vigilance of thinking Subject RIV: AA - Philosophy ; Religion http://envigogika.cuni.cz/index.php/Envigogika/issue/view/22

  10. Zdanění příjmů obchodních společností a jejich společníků (srovnání právní úpravy v ČR a ve vybraných zemích EU)

    OpenAIRE

    Bobek, Pavel

    2015-01-01

    The topic of this thesis is comparison of income taxation of companies and their shareholders or partners in Czech republic and other EU countries. For purposes of this thesis Czech legislation is compared to legislation of Slovak republic and Netherlands. The aim of the thesis is to give a complex overview and comparison of different tax legislations. The reason for choosing this topic is that knowledge of tax burden in particular country is important for making a decision where to start a c...

  11. Daň z příjmů právnických osob (daňové úniky, daňová optimalizace a jejich souvislost s účetnictvím)

    OpenAIRE

    Čermáková, Hana

    2014-01-01

    The Diploma thesis deals with the tax optimization and tax evasion relating to corporate income tax from the perspective of business entities who keeps accounts. Specifically, it is based on the legislation in force for the Czech Republic and is focused on the transformation process of accounting profit to the tax base of corporate income tax and the related possibilities of tax optimization or tax fraud. First chapter defines corporate income tax, its position in the tax system and the princ...

  12. Příspěvek k poznání petrografie, mineralogie a fluidních inkluzí jeskynních sintrů první generace z Koněpruských jeskyní a z některých lokalit v jejich okolí

    Czech Academy of Sciences Publication Activity Database

    Suchý, V.; Dobeš, P.; Zeman, Antonín

    2014-01-01

    Roč. 47, č. 1 (2014), s. 140-143 ISSN 0514-8057 Institutional support: RVO:68378297 Keywords : Bohemian Karst * speleothems * aragonite * gothic -arch calcite * fluid inclusions Subject RIV: AL - Art, Architecture, Cultural Heritage http://www.geology.cz/img/zpravyvyzkum/fulltext/Zpr2013D-11.pdf

  13. Následky léčby dětských nádorových onemocnění v oblasti neurokognitivních funkcí a jejich vliv na kvalitu života

    Czech Academy of Sciences Publication Activity Database

    Kepák, T.; Blatný, Marek; Vlčková, Irena; Navrátilová, P.; Kárová, Š.; Pavelková, K.; Pilát, M.; Jelínek, Martin; Mazánek, P.; Múdry, P.; Hrstková, H.

    2007-01-01

    Roč. 8, č. 6 (2007), s. 353-357 ISSN 1213-0494 Institutional research plan: CEZ:AV0Z70250504 Keywords : quality of life * neurocognitive functions * late effects of treatment Subject RIV: AN - Psychology

  14. Aféra Nagygate mezi korupcí a organizovaným zločinem: korupční sítě a jejich možný vliv na kvalitu demokracie v České republice

    Directory of Open Access Journals (Sweden)

    Petr Kupka

    2014-12-01

    Full Text Available The paper addresses the question of what sort of influence organized crime may have on democratic performance in the Czech Republic and which dimensions of its political system (if any are endangered most. We define organized crime narrowly in terms of corruption networks, questioning in effect the predominant understanding of these two concepts as distinct or even exclusive phenomena. The paper thus construes corruption and organized crime as concepts referring to transgressive acts (i.e. behaviour that involves a violation of moral or social boundaries that do not have to be legally codified, rather than in terms of legal norms. The influence of corruption networks is demonstrated on the case of the "Nagygate" scandal, which is analysed by utilising the framework of possible harms, as developed by Michael Maltz. We argue that the debate on organized crime in the Czech Republic is, in fact, inherently tied to the study of corruption, since corruption constitutes an integral part of organized criminal activities. Our findings show that transgressive behaviour has mostly negative impacts that include the loss of trust, widespread beliefs that injustice goes unpunished, a weakening of the political system, and the overall degeneration of the democratic regime. Moreover, the Nagygate scandal provides evidence that democratic institutions are not solely the victim of organized crime but also a possible source of transgressive activities.

  15. Zvířata v katedrále. Architektonická skulptura zvířat a fantaskních tvorů parléřovské huti v katedrále sv. Víta, jejich symbolika a ikonografie.

    OpenAIRE

    Urbanová, Karolína

    2017-01-01

    This Master Thesis "The animals in the cathedral. Architectural sculpture of animals and fantastical creatures by parlerian lodge in the St. Vitus Cathedral, their symbols and iconography" looks into the architectural sculpture of animal's motifs and motifs of fantastical Creatures. The goal of this work is to summarize recent aspects of research about this theme, explain in more detail individually motifs of animal's and their Iconography and their meaning for Cathedral of St. Vitus. Also th...

  16. Potřeby klientů domu na půl cesty v rámci tvorby a realizace vlastních volnočasových aktivit a definování parametrů programu pro jejich podporu

    OpenAIRE

    Kholl, Pavel

    2013-01-01

    This diploma thesis deals with a leisure time of clients of the Halfway House. The aim of the thesis is to map the content and structure of their leisure time. The thesis seeks to define what the representatives of the target group need for better self realization. Based on these findings author of the thesis design a new program supporting their spending of leisure time. The thesis consists of two parts: theoretical part and practical part. The theoretical part presents a halfway house socia...

  17. Míra pocitu ohrožení zaměstnanců a faktor stresu v kontextu jejich pracovní výkonnosti na příkladu podniku ArcelorMittal Tubular Products Karviná a. s

    Directory of Open Access Journals (Sweden)

    Štefan Hečko

    2014-03-01

    Full Text Available Purpose of the article: The article concerning human resource management focuses on the employee feeling of threat level and its influence on the work performance in a specific manufacturing company in the Czech Republic. The article, firstly, defines basic safety-related terminology such as threat, fear, stress, and safety threats. Secondly, it describes perception of stress and threat, together with their influence and impact on personal and work life of an individual. Finally, it presents the results of research done among employees and top management in the company ArcelorMittal Tubular Products Karviná a. s. Methodology/methods: Methodology is based on analysis of primary data acquired from the research and analysis of secondary data from the professional literature. An explorative method of questioning was used to acquire the primary research data (a questionnaire for the employees, a semi-formalized interview for the top management. Level one of quantitative classification comparison, statistical tools of MS Excel, and Statistical Package for the Social Sciences programme were used for the purpose of the analysis. Furthermore, methods of induction, deduction were used and based on the research results suggestions of measures for the company personnel activities were stated. Scientific aim: The aim of the research is to detect the employee feeling of threat level and its influence on their work performance in the company and to suggest measures for the company personnel activities, which could be implemented by the company management in the future. Findings: This article offers a complex insight into a specific company employee safety and the employee feeling of threat level and its influence on the work performance. The article presents a set of measures for the company personnel activities, which could help increase the workflow quality. Conclusions: Suggested measures, within the company human resource management, can contribute to an increase in the employee work life quality. Employee mental temper is influenced also by the level of stress felt by the employee when getting to/from work. Good working conditions are essential for acquiring and keeping the quality and qualified employees as well as for successful existence in the high competitive national and international globalized markets.

  18. Zdanění příjmů obchodních společností a jejich účastníků (srovnání právní úpravy v ČR a ve vybraných státech EU - SR a PR)

    OpenAIRE

    Boháček, Pavel

    2010-01-01

    87 Resumé This diploma thesis named "Taxation of income of companies and their participants (comparison of legal regulations in the selected EU states - the Czech Republic, Slovakia and Poland)". The thesis is divided into a theoretical and practical part. Chapters 1 - 6 form the theoretical part and chapters 7 - 9 form the practical part. The theoretical part contains a definition of tax, possible division of taxes, definition of a tax system and description of the structure of tax systems i...

  19. Dovedně zvládnutá přítomnost přináší příjemnou budoucnost: Sociální reprezentace smrti na Srí Lance u Theravádových mnichů a jejich podpůrců

    Czech Academy of Sciences Publication Activity Database

    Hytych, Roman

    2006-01-01

    Roč. 50, č. 3 (2006), s. 273-284 ISSN 0009-062X Institutional research plan: CEZ:AV0Z70250504 Keywords : social representations * death * cultural psychology Subject RIV: AN - Psychology Impact factor: 0.279, year: 2006

  20. Názory a postoje k návykovým látkám a jejich užívání u žáků šestých tříd základních škol: metoda ohniskových skupin

    Czech Academy of Sciences Publication Activity Database

    Miovský, Michal; Trapková, B.; Miovská, L.

    2004-01-01

    Roč. 4, č. 3 (2004), s. 306-317 ISSN 1213-3841 R&D Projects: GA ČR GP406/04/P250 Institutional research plan: CEZ:AV0Z7025918 Keywords : primary prevention * evaluation * addictive substances Subject RIV: AN - Psychology

  1. Sourozenci onkologicky nemocných dětí: subjektivně vnímané změny v životě a kvalita jejich života 6 měsíců po stanovení diagnózy nemocnému sourozenci

    Czech Academy of Sciences Publication Activity Database

    Kárová, Š.; Blatný, Marek; Jelínek, Martin; Kepák, T.; Tóthová, K.

    2013-01-01

    Roč. 57, č. 3 (2013), s. 218-229 ISSN 0009-062X R&D Projects: GA ČR GA406/09/1255 Institutional support: RVO:68081740 Keywords : oncology disease * siblings * quality of life Subject RIV: AN - Psychology Impact factor: 0.292, year: 2013

  2. Komunikace, rodičovská kontrola a gender rozdíly v rodičovských stylech a jejich vliv na užívání alkoholu u žáků šestých tříd zapojených do projektu Unplugged

    OpenAIRE

    Stará, Iveta

    2015-01-01

    BACKGROUND: Foreign studies shown, that parenting style and specific aspects of parenting has effect to children in alcohol consumption. In family style, with minimum alcohol consumption were children from families who enforced authoritative parenting style, also in families where parents communicate with children, give them clear boundaries and control them. AIMS: The aim of the research part of the thesis is to investigate the relationship between communication style, selected aspects of pa...

  3. Viniční terasy jako refugia pro výskyt xerotermních druhů pavouků (Araneae) a jejich bioindikační využití v hodnocení kvality životního prostředí a úrovně biodiverzity

    OpenAIRE

    Košulič, Ondřej

    2014-01-01

    The large-scale decline of traditionally managed early-successional habitats caused by the joint effects of agricultural intensification and abandonment of marginal lands has resulted in a critical reduction of xerophilous arthopods throughout Europe. The question is whether newly generated early-successional sites of human-made habitats (in this case vineyard terraces) may partially compensate this habitat loss. My research, therefore, focusses on spiders as model organisms to determine the ...

  4. Kulturistická příprava na soutěž - porovnání soutěžních kategorií a jejich odlišnosti v přípravě.

    OpenAIRE

    Jirkovský, David

    2018-01-01

    In the following theses, I would like to focus on bodybuilding preseason with competitive ambitions, describe the preparation in detail, explain the sequence, main attributes, synchronization, correct posing and common mistakes. In addition, I aim to compare variances of individual categories and particular competitions from amateur to professional level under the rules of IFBB (International Federation of Bodybuilding and Fitness). My thesis might clash with rules and categories of other org...

  5. Jak souvisí změny v rozšíření kriticky ohrožených druhů rostlin České republiky s jejich biologickými vlastnostmi a ekologickými nároky?

    Czech Academy of Sciences Publication Activity Database

    Gabrielová, J.; Černá, L.; Münzbergová, Zuzana

    2011-01-01

    Roč. 2011, č. 31 (2011), s. 345-371 ISSN 1211-3603 R&D Projects: GA ČR GD206/08/H049; GA MŠk 2B06178 Institutional research plan: CEZ:AV0Z60050516 Keywords : grid mapping * life-history traits * rarity Subject RIV: EF - Botanics

  6. Komparace gramotnosti a možnosti vzdělávání žen v Indii letech 1991 a 2011 a jejich možný vliv na populační vývoj

    OpenAIRE

    Kofrová, Michaela

    2011-01-01

    The bachelor thesis analyzes the access of women to education and its possible effect on demographic trends of India in 1991 and 2011. The first chapter generally characterizes the importance of education as means of escape from the poverty trap. The second chapter describes the progress in educational system in India, government development schemes focused on education in India and access of women to education in India from 1991 to nowadays. The third chapter presents the total fertility rat...

  7. Interakce rostlin, půdy a půdních živočichů a jejich vliv na sukcesi rostlinných a živočišných společenstev na disturbovaných územích

    Czech Academy of Sciences Publication Activity Database

    Frouz, Jan

    2006-01-01

    Roč. 41, č. 21 (2006), s. 65-71 ISSN 1212-3323 R&D Projects: GA ČR(CZ) GA526/01/1055; GA ČR(CZ) GA526/06/0728; GA AV ČR 1QS600660505 Institutional research plan: CEZ:AV0Z60660521 Keywords : herbivory * nutrient availability * plants Subject RIV: EH - Ecology, Behaviour

  8. Některé projevy sociální patologie u dětí a mládeže a možnosti jejich prevence z pohledu pedagoga volného času

    OpenAIRE

    BÁRTOVÁ, Lenka

    2008-01-01

    The thesis deals with problems of social pathology in context of importance of leisure time on children and juvenils. The work attends to characterization of leisure time and the social pathologic phenomena, to the chosen demonstrate of social pathology and chances of prevention in the teoretical part. Practical part inquire into student´s and the pedagogical personnel´s ideas of problems of social pathology and leisure time. The research deals with prevention and leisure time activity analys...

  9. Zdanění příjmů kapitálových společností a jejich společníků v kontextu mezinárodního zdanění

    OpenAIRE

    Štefková, Tereza

    2016-01-01

    Due to economic globalization, which is reflected, among others, in the development of international economic relations, it is very common that the companies are doing business in countries all over the world. Even if this phenomena is considered as positive in terms of national economies development, the risk of conflict of national laws and emergence of international double taxation is increasing with the expansion of cross-border investments. In connection with this a number of legal issue...

  10. Působení atropinu a diazepamu na savčí nervosvalové ploténce – model jejich ochranného působení při otravě bojovými a zemědělskými anticholinesterázami

    Czech Academy of Sciences Publication Activity Database

    Vyskočil, František

    2006-01-01

    Roč. 55, č. 3 (2006), s. 111-113 ISSN 1210-6313 R&D Projects: GA AV ČR(CZ) IAA5011411; GA ČR(CZ) GA305/02/1333; GA MŠk(CZ) LC554 Institutional research plan: CEZ:AV0Z50110509 Keywords : anticholinesterase * endplate * muscle membrane Subject RIV: ED - Physiology

  11. Evropská a česká doporučení diagnostických a léčebných postupů u ateriální hypertenze a jejich význam pro praxi

    Czech Academy of Sciences Publication Activity Database

    Peleška, Jan; Anger, Z.; Tomečková, Marie; Zvárová, Jana

    2004-01-01

    Roč. 2, č. 4 (2004), s. 29-32 ISSN 1214-231X R&D Projects: GA AV ČR 1ET200300413 Institutional research plan: CEZ:AV0Z1030915 Keywords : hypertension guidelines * cardiovascular risk evaluation * SCORE project Subject RIV: FQ - Public Health Care, Social Medicine

  12. Nálezy terry sigillaty v oblasti pod Pavlovskými vrchy (jižní Morava) a jejich vypovídací hodnota pro zkoumání římsko-barbarských vztahů

    Czech Academy of Sciences Publication Activity Database

    Klanicová, Soňa

    2010-01-01

    Roč. 2010, č. 51 (2010), s. 139-155 ISSN 1211-7250 R&D Projects: GA ČR GA404/09/1054 Institutional research plan: CEZ:AV0Z80010507 Keywords : Roman period * Samian ware * Hradisko Hill near Mušov * Germanic settlement * Roman pottery Subject RIV: AC - Archeology, Anthropology, Ethnology

  13. Charita a sociální učení církve. Reflexe jejich vztahu (zejména na základě historického vývoje a magisteriálních dokumentů

    Directory of Open Access Journals (Sweden)

    Petr Štica

    2013-09-01

    Full Text Available This study is concerned with the relation between charity and Catholic Social Teaching, particularly from the perspective of their historical development and on the basis of magisterial documents. First, the historical development in both areas is presented. Firstly, their common biblical and historical roots, and then both areas are differentiated and described. Secondly, the relation between charity and Catholic Social Teaching in the encyclical Deus Caritas Est (2006 is presented, as well as its social-ethical aspects. Finally, some possibilities regarding the interaction of both areas in the social engagement of the Church are outlined.

  14. Výskyt rizikových faktorů ischemické choroby srdeční u pacientů s akutním infarktem myokardu a jejich význam pro krátkodobou prognózu

    Czech Academy of Sciences Publication Activity Database

    Monhart, Z.; Faltus, Václav; Grünfeldová, H.; Ryšavá, D.; Hubač, J.; Velimský, T.; Ballek, J.; Janský, P.

    2007-01-01

    Roč. 49, 4 suppl (2007), s. 73-74 ISSN 0010-8650. [Výroční sjezd České kardiologické společnosti /15./. 13.05.2007-16.05.2007, Brno] Institutional research plan: CEZ:AV0Z10300504 Keywords : ICHS * rizikové faktory * mortalita Subject RIV: BB - Applied Statistics, Operational Research

  15. RemembeRINGs : the development and application of local and regional tree-ring chronologies of oak for the purposes of archaeological and historical research in the Netherlands

    NARCIS (Netherlands)

    Jansma, E.

    1995-01-01

    In dit proefschrift komen diverse methoden en toepassingen van dendrochronologie aan de orde. Samenvattend kan gesteld worden dat de onderzoeksdoeleinden die in de introductie (Hoofdstuk 1) werden omschreven, zijn bereikt. Nieuwe jaarring - kalenders zijn vervaardigd uit eikehout dat afkomstig is

  16. CDM Project Opportunities in Thailand

    DEFF Research Database (Denmark)

    2009-01-01

    Interview on Channel 2 UBC Thailand Fysisk medie: .dat mpeg video file Tidspunkt for udsendelse: 2003/06/28......Interview on Channel 2 UBC Thailand Fysisk medie: .dat mpeg video file Tidspunkt for udsendelse: 2003/06/28...

  17. Moral development and juvenile sex offending

    NARCIS (Netherlands)

    van Vugt, E.S.

    2011-01-01

    Eveline van Vugt onderzocht gewetensontwikkeling en delinquentie. Uit haar onderzoek bleek dat delinquenten met een gebrekkige gewetensontwikkeling een groot risico lopen om terug te vallen in delinquent gedrag. Opvallend was dat jongeren die een zedendelict hadden gepleegd eenzelfde

  18. Thermoelectric effects in magnetic nanostructures

    NARCIS (Netherlands)

    Bakker, Frank Lennart

    2012-01-01

    Elektronentransport is een belangrijk natuurkundig verschijnsel dat vaak wordt gebruikt in de hedendaagse technologie. Alle elektrische apparaten, variërend van stofzuigers tot computerchips, zijn in principe gebaseerd op dit type transport. Ondanks dat elektronen meerdere eigenschappen hebben,

  19. Populariteit, maar niet geliefdheid, is gerelateerd aan risicogedrag van Nederlandse adolescenten

    NARCIS (Netherlands)

    Broek, N. van den; Deutz, M.H.F.; Franken, A.; Cillessen, A.H.N.

    2017-01-01

    Ondanks dat theoretisch en empirisch bewijs aantoont dat Amerikaanse en Australische adolescenten risicogedrag vertonen om sociale status te verwerven, is er weinig bekend over de relatie tussen risicogedrag en sociale status bij Europese adolescenten. De huidige studie onderzocht deze relatie

  20. Wel vocht afvoeren maar geen warmte: Wageningen UR-kassen in Bleiswijk gaan 'nauwkeurig kieren'

    NARCIS (Netherlands)

    Vries, de J.W.

    2006-01-01

    Uit onderzoek blijkt dat het kasklimaat ook bij gesloten schermen goed kan worden gestuurd. Voorwaarde is dat een teler de schermen en ramen op een kier kan zetten. Daarbij moet hij die kieren wel heel nauwkeurig kunnen instellen

  1. 'Verleid consumenten tot gezond gedrag'

    NARCIS (Netherlands)

    Trijp, van J.C.M.

    2008-01-01

    Dat de gemiddelde Nederlander niet gezond leeft, dat is ondertussen bekend. Maar wat doe je eraan? Met marketing kom je een heel eind, weet Hans van Trijp, hoogleraar bij de Wageningse leerstoelgroep Marktkunde en consumentengedrag

  2. VizieR Online Data Catalog: HST photometry of M31 globular clusters (Federici+, 2012)

    Science.gov (United States)

    Federici, L.; Cacciari, C.; Bellazzini, M.; Fusi Pecci, F.; Galleti, S.; Perina, S.

    2013-01-01

    Tables g58.dat, g108.dat, g105.dat, g219.dat, b468.dat, g1.dat, g64.dat, g87.dat, g119.dat, g287.dat, g302.dat, g11.dat, g33.dat, g76.dat, g312.dat, g319.dat, g322.dat present the photometry of the individual stars of 17 M31 globular clusters observed with the WFPC2 on board of the HST, employing the F555W/F814W filters (Fusi Pecci et al. 1996AJ....112.1461F (FFP96), Rich et al. 2005AJ....129.2670R (R05)). The data reduction has been performed using ROMAFOT (Buonanno et al. 1983A&A...126..278B), a multicomponent fitting package purposely adapted to handle HST data, that provides as output the magnitudes and the pixel positions of the detected sources. The CTE-corrected photometric data were converted to the Johnson-Cousins V,I magnitudes according to Holtzman et al (1995PASP..107..156H). Table g351.dat presents the photometry of the individual stars of the M31 globular cluster B405-G351 observed with the HST/COSTAR-corrected FOC + the F430W/F480LP filters. The data reduction has been performed using ROMAFOT; the photometric data were converted to the Johnson-Cousins system B,V magnitudes (see FFP96). Tables gc1.dat, gc2.dat, gc3.dat, gc5.dat, gc6.dat, gc7.dat, gc8.dat, gc9.dat, gc10.dat, gc4.dat, ec1.dat, ec2.dat, ec3.dat, ec4.dat present the photometry of the individual stars of 14 M31 globular clusters observed with the WFC/ACS on board of the HST + F435W/F606W filters (see Galleti et al., 2006ApJ...650L.107G; Mackey et al., 2007ApJ...655L..85M; Mackey et al., 2006ApJ...653L.105M). The data reduction has been performed using the ACS module of DOLPHOT, a point spread function-fitting package specifically devoted to the photometry of HST data, that provides as output the magnitudes and the pixel positions of the detected sources, and a number of quality parameters for a suitable sample selection. The tables present, for the ACS chip holding the cluster, all the stars with valid measurements in both passbands, global quality flag=1, crowding parameter 23.5,and noise

  3. Opvoeders se persepsies van hulle werkmotivering: 'n kwalitatiewe ...

    African Journals Online (AJOL)

    Erna Kinsey

    Individue voel dat hulle self geen beheer oor die proses het nie en dat die verandering van buite ...... treatment has a negative influence on their self-esteem and moti- vation. ... tion, especially since the abolishment of corporal punishment.

  4. Audit-based Access Control in de Zorg

    NARCIS (Netherlands)

    Dekker, M.A.C.; Kuiper, R.; Veugen, P.J.M.; Etalle, Sandro

    2006-01-01

    Traditioneel staan in de informatiebeveiliging vertrouwelijkheid en beschikbaarheid van informatie op een gespannen voet. Grofweg geldt dat hoe meer maatregelen worden genomen om informatie af te schermen voor buitenstaanders, hoe eerder het voorkomt dat geautoriseerde personen niet tijdig toegang

  5. Complement binding to erythrocytes is associated with macrophage activation and reduced haemoglobin in Plasmodium falciparum malaria

    DEFF Research Database (Denmark)

    Goka, B Q; Kwarko, H; Kurtzhals, J A

    2001-01-01

    parameters were significantly higher in DAT-positive than in DAT-negative patients (P macrophage activation. Plasma levels of haptoglobin, interleukin-10 and tumour necrosis factor-alpha did not vary between the groups...

  6. Piketty en Smith : een bijzonder span?

    NARCIS (Netherlands)

    Gribnau, J.L.M.

    Piketty belicht economische, politieke, ethische en sociale aspecten van belastingen. Sloterdijk betoogde al eerder dat belastingen een moreel verschijnsel zijn. Adam Smith heeft een al even breed perspectief op belastingen. Piketty en Smith delen de idee dat belastingen vanuit verschillende

  7. My dopamine has been busy: Research on gene by environment interactions in child externalizing behavior

    NARCIS (Netherlands)

    Chhangur, R.R.

    2016-01-01

    De algehele resultaten in dit proefschrift lieten zien dat het dopaminesysteem kan worden beschouwd als een belangrijk onderliggend neurobiologisch systeem dat het verband tussen de gevoeligheid van kinderen voor, respectievelijk, positief en negatief opvoedingsgedrag kan verklaren. Met name hebben

  8. Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors

    DEFF Research Database (Denmark)

    Cao, Jianjing; Slack, Rachel D.; Bakare, Oluyomi M.

    2016-01-01

    The development of pharmacotherapeutic treatments of psychostimulant abuse has remained a challenge, despite significant efforts made toward relevant mechanistic targets, such as the dopamine transporter (DAT). The atypical DAT inhibitors have received attention due to their promising pharmacolog...

  9. Evaluation of a novel stent technology: the Genous EPC capturing stent

    NARCIS (Netherlands)

    Klomp, M.

    2012-01-01

    Tegenwoordig gebruiken ziekenhuizen een nieuwe stent bij dotterbehandelingen van kransslagadervernauwingen. Deze Genous-stent heeft een laag met antistoffen waardoor het behandelde bloedvat snel bedekt raakt met lichaamseigen cellen. Zo wordt tegengegaan dat er opnieuw een vernauwing optreedt of dat

  10. Sortiment biologische laanbomen en sierheesters onder het vergrootglas : interview met Margareth Hop

    NARCIS (Netherlands)

    Jacobs, R.; Hop, M.E.C.M.

    2010-01-01

    In tegenstelling tot de traditionele boomkwekerijgewassen is binnen de Nederlandse boomkwekerijsector de markt voor biologische boomkwekerijproducten nog steeds uiterst bescheiden. Telers horen vaak van afnemers dat het nog beperkte sortiment dat biologisch leverbaar is, hier mee te maken heeft.

  11. Korpusy jako zdroje dat pro úpravy nástrojů automatické morfologické analýzy (Slovotvorné varianty adjektiv na [(ou|í]cí z hlediska morfologického značkování : Corpora as Data Sources for the Up-Grading of Morphological Tagging

    Directory of Open Access Journals (Sweden)

    Osolsobě, Klára

    2015-10-01

    Full Text Available Adjectives ending with -oucí/-ící are regularly derived from verbs and hence are not usually listed in any of the Czech monolingual dictionaries. On the level of automatic morphological analysis (the dictionary of Czech they should be generated from verbal roots and tagged as verbal adjectives (pos tag: AG.*. The data from Czech corpora prove a inconsistencies in tagging and b gaps in the dictionary. The main cause of both kinds of insufficiency is the existence of variants on the level of verbal forms from which the verbal adjectives are potentially derived. Consequently, text corpora are a significant sourceof knowledge about the formation and use of adjectives with endings -oucí/-ící that can be important for both a automatic morphological analysis of Czech and b theoretical description of Czech grammar(derivational morphology. Our goal is to present a corpus-based study of the Czech gerund, i.e. verbaladjectives with -oucí/-ící. The link between the inflected and the word-formation variants will bedemonstrated using material from the SYN corpus (2,6 billion tokens of written Czech and the large web corpus czTenTen12 (5,2 billion tokens of Czech text from the Internet — cleaned and deduplicated.

  12. Srovnání nejpoužívanějších účetních softwarů v ČR z hlediska možnosti zpracování účetních dat

    OpenAIRE

    BĚHOUNKOVÁ, Martina

    2007-01-01

    The aim of the these is to compare and evaluace of processing in choice Accounting software. Computer technology can be helpful in the process of accounting. Accounting software are is an integral part of accounting administration. Nowadays a lot of accounting and economic software are on the market. It is necessary to chaose a adequate software for effectiveness of the company. The right choice of software programme can be the first step of firm functioning.

  13. Dálkový archeologický průzkum starého sídelního území Čech. Konfrontace výsledků letecké prospekce a analýzy družicových dat

    Czech Academy of Sciences Publication Activity Database

    Gojda, Martin; John, J.

    2009-01-01

    Roč. 61, č. 3 (2009), s. 467-492 ISSN 0323-1267 Institutional research plan: CEZ:AV0Z80020508 Keywords : remote sensing of the Earth * satellite archaeology * non-destructive archaeological methods * panchromatic and multispectral images * aerial reconnaissance Subject RIV: AC - Archeology, Anthropology, Ethnology

  14. Znečištění ovzduší v Praze, Teplicích a v Prachaticích v uplynulých 15 letech. Porovnání dat a úvaha nad změnami a trendy

    Czech Academy of Sciences Publication Activity Database

    Beneš, I.; Skorkovský, J.; Novák, J.; Šrám, Radim

    5-6, - (2010), s. 18-23 ISSN 1211-0337 R&D Projects: GA MŽP(CZ) SP/1B3/8/08; GA MŽP(CZ) SP/1B3/50/07 Institutional research plan: CEZ:AV0Z50390512 Keywords : air pollution * sulfur dioxide * carbon monoxide Subject RIV: DN - Health Impact of the Environment Quality

  15. Reduction in camera-specific variability in [{sup 123}I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls

    Energy Technology Data Exchange (ETDEWEB)

    Buchert, Ralph; Lange, Catharina [Charite - Universitaetsmedizin Berlin, Department of Nuclear Medicine, Berlin (Germany); Kluge, Andreas; Bronzel, Marcus [ABX-CRO advanced pharmaceutical services Forschungsgesellschaft m.b.H., Dresden (Germany); Tossici-Bolt, Livia [University Hospital Southampton NHS Foundation Trust, Department of Medical Physics, Southampton (United Kingdom); Dickson, John [University College London Hospital NHS Foundation Trust, Institute of Nuclear Medicine, London (United Kingdom); Asenbaum, Susanne [Medical University of Vienna, Department of Nuclear Medicine, Vienna (Austria); Booij, Jan [University of Amsterdam, Department of Nuclear Medicine, Academic Medical Centre, Amsterdam (Netherlands); Kapucu, L. Oezlem Atay [Gazi University, Department of Nuclear Medicine, Faculty of Medicine, Ankara (Turkey); Svarer, Claus [Rigshospitalet and University of Copenhagen, Neurobiology Research Unit, Copenhagen (Denmark); Koulibaly, Pierre-Malick [University of Nice-Sophia Antipolis, Nuclear Medicine Department, Centre Antoine Lacassagne, Nice (France); Nobili, Flavio [University of Genoa, Department of Neuroscience (DINOGMI), Clinical Neurology Unit, Genoa (Italy); Pagani, Marco [CNR, Institute of Cognitive Sciences and Technologies, Rome (Italy); Karolinska Hospital, Department of Nuclear Medicine, Stockholm (Sweden); Sabri, Osama [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Sera, Terez [University of Szeged, Department of Nuclear Medicine and Euromedic Szeged, Szeged (Hungary); Tatsch, Klaus [Municipal Hospital of Karlsruhe Inc, Department of Nuclear Medicine, Karlsruhe (Germany); Borght, Thierry vander [CHU Namur, IREC, Nuclear Medicine Division, Universite catholique de Louvain, Yvoir (Belgium); Laere, Koen van [University Hospital and K.U. Leuven, Nuclear Medicine, Leuven (Belgium); Varrone, Andrea [Karolinska University Hospital, Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm (Sweden); Iida, Hidehiro [National Cerebral and Cardiovascular Center - Research Institute, Osaka (Japan)

    2016-07-15

    Quantitative estimates of dopamine transporter availability, determined with [{sup 123}I]FP-CIT SPECT, depend on the SPECT equipment, including both hardware and (reconstruction) software, which limits their use in multicentre research and clinical routine. This study tested a dedicated reconstruction algorithm for its ability to reduce camera-specific intersubject variability in [{sup 123}I]FP-CIT SPECT. The secondary aim was to evaluate binding in whole brain (excluding striatum) as a reference for quantitative analysis. Of 73 healthy subjects from the European Normal Control Database of [{sup 123}I]FP-CIT recruited at six centres, 70 aged between 20 and 82 years were included. SPECT images were reconstructed using the QSPECT software package which provides fully automated detection of the outer contour of the head, camera-specific correction for scatter and septal penetration by transmission-dependent convolution subtraction, iterative OSEM reconstruction including attenuation correction, and camera-specific ''to kBq/ml'' calibration. LINK and HERMES reconstruction were used for head-to-head comparison. The specific striatal [{sup 123}I]FP-CIT binding ratio (SBR) was computed using the Southampton method with binding in the whole brain, occipital cortex or cerebellum as the reference. The correlation between SBR and age was used as the primary quality measure. The fraction of SBR variability explained by age was highest (1) with QSPECT, independently of the reference region, and (2) with whole brain as the reference, independently of the reconstruction algorithm. QSPECT reconstruction appears to be useful for reduction of camera-specific intersubject variability of [{sup 123}I]FP-CIT SPECT in multisite and single-site multicamera settings. Whole brain excluding striatal binding as the reference provides more stable quantitative estimates than occipital or cerebellar binding. (orig.)

  16. Daň z nemovitých věcí v Praze: kvantifikace současné situace a možných změn pomocí dat z daňových přiznání

    Czech Academy of Sciences Publication Activity Database

    Janský, Petr; Šatava, Jiří

    2015-01-01

    Roč. 23, č. 4 (2015), s. 43-62 ISSN 0572-3043 Institutional support: RVO:67985998 Keywords : property tax * tax returns * impact evaluation Subject RIV: AH - Economics http://www.vse.cz/polek/download.php?jnl=aop&pdf=480.pdf

  17. De werkhouding bevorderen aan de hand van een growth mindset: Hoe kan je als leerkracht van groep acht op PCB de Oranje Nassau in Zwammerdam de growth mindset van leerlingen bevorderen zodat leerlingen in de werkhouding laten zien dat zij het proces van eigen doelen belangrijker vinden dan cijfers?

    OpenAIRE

    Vis, Wieke

    2017-01-01

    In dit onderzoek staat de verbinding tussen het leren zichtbaar maken van Hattie (2008) en de theorie van de mindsets van Dweck (2007) centraal. Het doel van dit onderzoek is om de werkhouding van leerlingen ten opzichte van eigen doelen te bevorderen aan de hand van een growth mindset. Het onderzoek wordt uitgevoerd op PCB de Oranje Nassau in Zwammerdam. Dit is een voorbeeldschool wat betreft wetenschap en techniek, en leren zichtbaar maken (Boer & Graaff, 2016). De school streeft naar onder...

  18. Clinical usefulness of dopamine transporter imaging

    International Nuclear Information System (INIS)

    Kim, Jong Min; Kim, Yu Kyeong; Kim, Sang Eun; Jeon, Beom S.

    2007-01-01

    Imaging of the dopamine transporter (DAT) provides a marker for the integrity of presynaptic nigrostriatal dopaminergic system. DAT density is reduced in Parkinson disease, multiple system atrophy, and progressive supranuclear palsy. In patients with suspicious parkinsonism, normal DAT imaging suggests an alternative diagnosis such as essential tremor, vascular parkinsonism, or drug-induced parkinsonism. DAT imaging is a useful tool to aid clinician's differential diagnosis in parkinsonism

  19. Infantile parkinsonism-dystonia: a dopamine “transportopathy”

    OpenAIRE

    Blackstone, Craig

    2009-01-01

    The dopamine transporter (DAT) retrieves the neurotransmitter dopamine from the synaptic cleft at dopaminergic synapses. Variations in solute carrier family 6A, member 3 (SLC6A3/DAT1), the human gene encoding DAT, have been implicated in attention deficit hyperactivity and bipolar disorders, and DAT is a prominent site of action for drugs such as amphetamines and cocaine. In this issue of the JCI, Kurian et al. report that an autosomal recessive infantile parkinsonism-dystonia is caused by lo...

  20. Bluedec in product design: Isolatiemateriaal op basis van aerogel

    OpenAIRE

    Beurden, van, K.M.M. (Karin); Goselink, E.A. (Erik)

    2014-01-01

    Aerogel is een zeer kostbaar voor de ruimtevaart ontwikkeld basismateriaal. Bluedec is een isolatiemateriaal bestaande uit een non woven kunststof dat met deze aerogel geïmpregneerd is. Hierdoor ontstaat een zeer goed isolerend materiaal dat goedkoper is dan aerogel. De warmtegeleidingscoëfficiënt van Bluedec in de basisuitvoering is 0,0135 W/m*K . Dat is lager dan conventionele isolatiematerialen, zie ook pagina 4. Voordeel hiervan is dat vergelijkbare of betere warmte-isolati...