Sample records for savio lau-ching woo

  1. WooCommerce cookbook

    CERN Document Server

    Rauland, Patrick


    If you have ever built or managed a WordPress site and want to add e-commerce functionality into your site, WooCommerce and this book are perfect for you. Learning how to use WooCommerce through this series of recipes will give you a solid platform to add any future e-commerce needs.

  2. Santo Domingo Savio: un territorio reterritorializado

    Directory of Open Access Journals (Sweden)

    Jorge Ivu00E1n Ballesteros Toro


    Full Text Available Santo Domingo Savio es un barrio de la Comuna Popular número 1,1 ubicado en el nororiente de la ciudad de Medellín (Antioquia, Colombia. Es un territorio formado a través de la ocupación marginal e ilegal de la tierra, que ha sido marcado por la violencia y la pobreza. El Estado, luego de años de abandono, ha implementado proyectos de desarrollo urbano que han generado infraestructura de transporte, espacio público y educación; proyectos que enmarcan la ciudad en el contexto de la competitividad. La actual dinámica territorial ha convertido esta comuna en un lugar atractivo para residentes y turistas, en un espacio reterritorializado por el Estado; además, ha transformado el lugar en un laboratorio de ciudad y en un modelo de renovación. Bajo este escenario, esta exploración pretende visualizar la territorialidad que en el transcurso del tiempo han tenido los diferentes actores en este espacio.

  3. Kolm Armastust ja Anarhiat. Nekrofiil, drellimõrvar ja John Woo Tallinnas / Jaan Ruus

    Index Scriptorium Estoniae

    Ruus, Jaan, 1938-2017


    Helsingi filmifestivali "Armastus ja Anarhia" mitme seansi toimumisest Eestis 1993.a. septembris : Abel Ferrara "Drellimõrvar" ("Driller Killer", 1979), sakslase Jörg Buttgereiti "Nekromantik" (1987) ja "Nekromantik 2" (1991), John Woo "Hard Boiled" (1993). Buttgereit ja Woo olid ka ise kohal

  4. Wooing-Scenes in “Richard III”: A Parody of Courtliness?

    Directory of Open Access Journals (Sweden)

    Agnieszka Stępkowska


    Full Text Available In the famous opening soliloquy of Shakespeare’s Richard III, Richard mightily voices his repugnance to “fair well-spoken days” and their “idle pleasures”. He realizes his physical deformity and believes that it sets him apart from others. He openly admits that he is “not shaped for sportive tricks, nor made to court an amorous looking-glass”. Yet, his monstrosity constitutes more perhaps of his aggressive masculine exceptionality rather than of his deformity. Richard’s bullying masculinity manifests itself in his contempt for women. In the wooing scenes we clearly see his pugnacious pursuit of power over effeminate contentment by reducing women to mere objects. Additionally, those scenes are interesting from a psychological viewpoint as they brim over with conflicting emotions. Therefore, the paper explores two wooing encounters of the play, which belong the best examples of effective persuasion and also something we may refer to as ‘the power of eloquence’.

  5. “Desarrollo de liderazgo en los adolescentes de primera generación en la parroquia de Santo Domingo Savio en Bellflower California, para el apoyo del proceso de evangelización en la iglesia católica”


    Montenegro, Juan Carlos


    El desarrollo de liderazgo en los adolecentes de primera generación en la parroquia de Santo Domingo Savio, en Bellflower, California, para el apoyo del proceso de “evangelización en la Iglesia Católica” es un tema que, a parte de ser interesante, es bastante necesario para el futuro de la Iglesia en Estados Unidos de Norte América. En el año 2010, Estados Unidos contaba con 50?729.5701 hispanos, de los cuales el 62.9% fueron nacidos en este país; el 33.8% de hispanos son jóvenes menores de 1...

  6. Wooing patients with technology. (United States)

    Myers, Michael


    Technologies that can give healthcare organizations a marketing advantage with patients include: Registration kiosks that request payment automatically, in a more comfortable environment for both patients and registration staff. Emails that enable patients to schedule initial visits and follow-up care. Secure online messaging platforms that enable patients to obtain timely answers to questions they have for their providers both before and after receiving services.

  7. Temporal Vulnerability and the Post-Disaster ‘Window of Opportunity to Woo' : A Case Study of an African-American Floodplain Neighborhood after Hurricane Floyd in North Carolina

    NARCIS (Netherlands)

    de Vries, D.H.

    After major flooding associated with Hurricane Floyd (1999) in North Carolina, mitigation managers seized upon the “window of opportunity” to woo residents to accept residential buyout offers despite sizable community resistance. I present a theoretical explanation of how post-crisis periods turn

  8. Temporal Vulnerability and the Post-Disaster 'Window of Opportunity to Woo:' a Case Study of an African-American Floodplain Neighborhood after Hurricane Floyd in North Carolina. (United States)

    de Vries, Daniel H


    After major flooding associated with Hurricane Floyd (1999) in North Carolina, mitigation managers seized upon the "window of opportunity" to woo residents to accept residential buyout offers despite sizable community resistance. I present a theoretical explanation of how post-crisis periods turn into "opportunities" based on a temporal referential theory that complements alternative explanations based on temporal coincidence, panarchy, and shock-doctrine theories. Results from fieldwork conducted from 2002 to 2004 illustrate how several temporal influences compromised collective calibration of "normalcy" in local cultural models, leading to an especially heightened vulnerability to collective surprise. Four factors particularly influenced this temporal vulnerability: 1) epistemological uncertainty of floodplain dynamics due to colonization; 2) cultural practices that maintained a casual amnesia; 3) meaning attributed to stochastic timing of floods; and 4) competitive impact of referential flood baseline attractors.

  9. Overseas airlines woo Chinese tourists

    Institute of Scientific and Technical Information of China (English)


    <正> A well-known ancient Chinese poet, Su Shi (1037-1101), used to describe the natural scene in April as: "Two or three sprays of peach behind bamboo; When spring warms the river the ducks are the first to know."As for the potential of China’s tourism industry, airline companies from other countries seem to be the "ducks" who have very good foresight about passenger loads as more Chinese travellers prefer overseas destinations as their first choice for holidays, especially the three week-long holidays, Spring Festival, May Day and National Day.As the May Day holiday approaches,

  10. St. Dominic Savio Nursing Home, Cahilly, Liscannor, Clare.

    LENUS (Irish Health Repository)

    Lee, Graham R


    High sensitivity cardiac troponin T and I (hs-cTnT and hs-cTnI) assays show analytical, diagnostic and prognostic improvement over contemporary sensitive cTn assays. However, given the importance of troponin in the diagnosis of myocardial infarction, implementing this test requires rigorous analytical and clinical verification across the total testing pathway. This was the aim of this study.

  11. Mozart, Hawthorne, and Mario Savio: Aesthetic Power and Political Complicity. (United States)

    Herbert, T. Walter


    Discusses the false dichotomy pitting aesthetic power against political complicity in literary criticism. Considers the sexual politics of the household of Nathaniel Hawthorne in light of this opposition. Suggests how literary works keep warring voices and inner conflicts alive and at odds. (HB)

  12. Mandando bocas: Woo and Sex among Sampadjudu Young Men

    Directory of Open Access Journals (Sweden)

    Francisco Miguel


    Full Text Available In this paper I deal with a Cape Verdean phenomenon: the mandar bocas (“to send mouths”. Specifically, I analyse the action of “mandar bocas” made by men in the town of Mindelo. At a first glance, this phenomenon could be quickly classified as “homophobic” slurs. I argue, however, that this is not the only possible interpretation of the phenomenon as “mandar bocas” is often a phase of a homoerotic courtship between young men in Cabo Verde, though permeated by masculinist signs.

  13. A spirited response: Malaysia's AIDS activists woo Muslim clerics. (United States)

    Oorjitham, S


    Islamic clerics, scholars, activists, and other authorities in Malaysia decided to lay in education for everyone as a solution to the AIDS epidemic in their country. In addition, they called on the community to be caring towards sufferers, which they believe is the way of Islam. This resolution was agreed upon during a meeting wherein religious officials recognized their role in AIDS prevention by equipping people with spiritual values and teaching everyone compassion. The resolution, however, has challenged the orthodoxy in some Islamic circles where AIDS is regarded as a "manifestation of God's punishment" which has consequently scared off many Muslim sufferers from approaching religious bodies. Religious advisers also admits that their call for full information about prevention, from urging abstinence and marital fidelity to promoting the use of condoms, still needs to be supported by individual state authorities. Among the AIDS council's future plans are to set up an information booth at a Kuala Lumpur mosque and to raise awareness in state religious departments through a booklet entitled AIDS Education Through Imams.

  14. Playing Roles (A Reading of Virginia Wooľf's Novel To the Lighthouse)


    Petrić-Bajlo, Estella


    Reading Virginia Woolf's novel To the Lighthouse in the light of the generally known understanding of art as subjective reflection of objective reality, we might conclude that this novel interrogates not only the subjectivity of that reflection but the objectivity of reality as well. A prevailing sense of seemingness stems especially from Lily Briscoe°s doing a painting which metonymically corresponds to the narrating of the story (Grgas 1988). The closing sentence of the novel, »I have...

  15. Vendors woo South Africa as a potential new 'powerhouse' for nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Shepherd, John [nuclear24, London (United Kingdom)


    South Africa is a country which is increasingly seen as a potential new nuclear market that promises to give one or more of the world's major nuclear vendors an important foothold on the continent. South Africa has two pressurised water reactors operating at the Koeberg nuclear plant. The 930-megawatt (MW) first unit entered commercial operation in July 1984, followed by the second (900 MW) unit in November 1985. These are the only commercial nuclear power plants on the continent of Africa. South Africa's updated draft integrated resources plan (IRP) for electricity for 2010-30, for which a public consultation period ended in February of this year, included revised projections. that suggested no new nuclear baseload capacity would be needed 'until after 2025'. A capacity 'at least 6,600 MW less' is required in terms of reliable overall generating capacity in 2030. However great South Africa's demand for a clean, affordable and reliable supply of nuclear-generated electricity, coupled with the economic benefits such developments will bring, investors also understand the potential for nuclear growth in this part of the world. (orig.)

  16. Listening to Hyun-woo: What Can We Learn from a Korean American English Learner? (United States)

    Han, Keonghee Tao; Scull, W. Reed


    English learners (ELs) from Confucian heritage culture (CHC) are often perceived to be reserved and conforming to the authority of the classroom. But a careful look at struggles between a CHC student and the mainstream teacher reveals that the teacher's views and pedagogical approaches shape academic and social hierarchy in the classroom.…

  17. Vendors woo South Africa as a potential new 'powerhouse' for nuclear

    International Nuclear Information System (INIS)

    Shepherd, John


    South Africa is a country which is increasingly seen as a potential new nuclear market that promises to give one or more of the world's major nuclear vendors an important foothold on the continent. South Africa has two pressurised water reactors operating at the Koeberg nuclear plant. The 930-megawatt (MW) first unit entered commercial operation in July 1984, followed by the second (900 MW) unit in November 1985. These are the only commercial nuclear power plants on the continent of Africa. South Africa's updated draft integrated resources plan (IRP) for electricity for 2010-30, for which a public consultation period ended in February of this year, included revised projections. that suggested no new nuclear baseload capacity would be needed 'until after 2025'. A capacity 'at least 6,600 MW less' is required in terms of reliable overall generating capacity in 2030. However great South Africa's demand for a clean, affordable and reliable supply of nuclear-generated electricity, coupled with the economic benefits such developments will bring, investors also understand the potential for nuclear growth in this part of the world. (orig.)

  18. Wooing the Dark Continent: U.S. and China Engagement Strategy in Africa, is it Complimentary or Competition (United States)


    put it directly in conflict with Tokyo in the South China Sea . China has been successful in using its “soft power” to reduce the leverage of the West...59Ibid., 20. 60Gill and Reilly, 43. 30 The Two China’s as well as the Mutually Parasitic Economies (US/China...environment for all parties involved. African Perspectives “Panda Hug or Dragon Bite?” “Until the lion has his or her own storyteller, the hunter will

  19. To Twitter to Woo: Harnessing the power of social media (SoMe) in nurse education to enhance the student's experience. (United States)

    Sinclair, Wendy; McLoughlin, Moira; Warne, Tony


    This paper explores some of the difficulties, challenges and rewards for student nurses and nurse academics when harnessing social media (SoMe) as part of the overall learning experience. The paper draws upon data in the form of student voices, captured through an online planned Twitter chat. This data analysis provides the basis of a case study on the student experience in practice placements. A planned 1 h Twitter chat took place in June 2013, specifically aimed at student nurses. What transpired was an illuminating debate, eliciting responses from around the globe about learning in practice, mentors, and student support that lasted over 3 h. More importantly, the Twitter chat also included qualified nurses and mentors, listening and responding in real time, offering thoughts and solutions to how support and mentoring could be improved. This was in contrast to how students, locally, currently use a paper based questionnaire to give feedback in isolation. The authenticity of this feedback is often compromised by university link lecturers' who often provide a more sanitised version of this feedback to clinical placement. This paper explores whether it is possible to facilitate a realignment and capture the zeitgeist in order to provide the opportunity for enhancing learning in practice. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. Is the Use of Video Conferencing and Supporting Technologies a Feasible and Viable Way to Woo Farmers Back into Farmer Education? (United States)

    Brown, Margaret; Fraser, Tom


    North Dakota State University (USA) have been using video conferencing as a delivery mode for farmer education for about twenty years and report that their farmers find this delivery method both practical and worthwhile. With the number of New Zealand farmers attending learning events decreasing, due mainly to time and cost, maybe it is time to…

  1. Oversight framework over oocyte procurement for somatic cell nuclear transfer: comparative analysis of the Hwang Woo Suk case under South Korean bioethics law and U.S. guidelines for human embryonic stem cell research. (United States)

    Kim, Mi-Kyung


    We examine whether the current regulatory regime instituted in South Korea and the United States would have prevented Hwang's potential transgressions in oocyte procurement for somatic cell nuclear transfer, we compare the general aspects and oversight framework of the Bioethics and Biosafety Act in South Korea and the US National Academies' Guidelines for Human Embryonic Stem Cell Research, and apply the relevant provisions and recommendations to each transgression. We conclude that the Act would institute centralized oversight under governmental auspices while the Guidelines recommend politically-independent, decentralized oversight bodies including a special review body for human embryonic stem cell research at an institutional level and that the Guidelines would have provided more vigorous protection for the women who had undergone oocyte procurement for Hwang's research than the Act. We also suggest additional regulations to protect those who provide oocytes for research in South Korea.

  2. The Bycatch Problem

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 12; Issue 5. The Bycatch Problem - Effects of Commercial Fisheries on Non-Target Species in India. Aaron Savio Lobo. General Article Volume 12 Issue 5 May 2007 pp 60-70 ...

  3. Recent advances in elasticity, viscoelasticity and inelasticity

    CERN Document Server

    Rajagopal, KR


    This is a collection of papers dedicated to Prof T C Woo to mark his 70th birthday. The papers focus on recent advances in elasticity, viscoelasticity and inelasticity, which are related to Prof Woo's work. Prof Woo's recent work concentrates on the viscoelastic and viscoplastic response of metals and plastics when thermal effects are significant, and the papers here address open questions in these and related areas.

  4. Geopressured-geothermal aquifers. Final contract report

    Energy Technology Data Exchange (ETDEWEB)


    Task 1 is to provide petrophysical and reservoir analysis of wells drilled into geopressured-geothermal aquifers containing dissolved methane. The list of Design Wells and Wells of Opportunity analyzed: Fairfax Foster Sutter No. 2 (WOO), Pleasant Bayou No. 2 (Design), Amoco Fee No. 1 (Design), G.M. Koelemay No. 1 (WOO), Gladys McCall No. 1 (Design), P.R. Girouard No. 1 (WOO), and Crown Zellerbach No. 2 (WOO). Petrophysical and reservoir analysis of the above wells were performed based on availability of data. The analysis performed on each well, the assumptions made during simulation, and conclusions reached.

  5. A System for Controlled Presentation of the Arden Contrast Sensitivity Test. (United States)


    and Woo,1978); I.?glaucoma (Atkin, et al,1979); amblyopia (Hess,1979); retinal degeneration (Woo and Long,1979); multiple sclerosis (Regan, et al...decrease, contrast sensitivity diminishes, and imaging L shifts to an area covering 12 -15 of the peripheral macula . The theoretical threshold grid

  6. Piezoelectric Nanogenerators for Self-Powered Nanosystems and Nanosensors (United States)


    researchers 1. Sangmin Lee, Sung-Hwan Bae, Long Lin, Seunghyun Ahn, Chan Park, Seung Nam Cha, Young Jun Park, Hyuk Chang, Sang-Woo Kim and...Sohn, Seung Nam Cha, Dukhyun Choi * Zhong Lin Wang * Sang-Woo Kim * “ P-Type Polymer–Hybridized High-Performance Piezoelectric Nanogenerators”, Nano...Yoon Lee, † Sang-Woo Kim , *,$ Jae-Young Choi, *,† Jong Min Kim , † and Zhong Lin Wang *, “Flexible Hybrid Multi-Type Energy Scavenger”, Energy

  7. Download this PDF file

    African Journals Online (AJOL)

    ... is an acquired skill of expressing a particular culture so that the message conveyed to the .... are beyond the control of a small-scale processor. Perhaps some .... Champman and Hall. Hardter, R., Woo ... Experience. London: Edward Arnold.

  8. Stalkerid sisekujundusmaastikul / Jan Joonas Graps, Ken-Kristjan Ruut ; intervjueerinud Aale Kask

    Index Scriptorium Estoniae

    Graps, Jan Joonas, 1972-


    Sisearhitektide Jan Joonas Grapsi ja Ken-Kristjan Ruudu loomingust, tehtud tööde loetelu. Sarjast WooDoo. Pelgulinnas Kaera 22 asuva korteri (arhitekt Harry Klaar) ja Murastes asuva eramu (arhitekt Mart Kadarik) sisekujundusest

  9. The Global Reach of Chinese Soft Power: China's Rise and America's Decline?

    National Research Council Canada - National Science Library

    Hoey, James H


    ...." Emerging from a shell of defensive diplomacy dating back decades, China suddenly has engaged the world, wooing friends with a subtle, softer approach to make gains as America's popularity has plummeted...

  10. Kes kardab Park Chan-Wooki? / Karlo Funk

    Index Scriptorium Estoniae

    Funk, Karlo, 1971-


    Vägivalla ajendite teemadel. USA meedia süüdistas peale Virginia koolitulistamist filmikunsti. Seoseid ja/või põhjusi otsiti korealase Park Chan-Wooki filmist "Vana poiss" ("Old Boy") ja John Woo filmidest

  11. Growth of mycotal species on the eggs of Cyprinus carpio in ...

    African Journals Online (AJOL)



    Feb 11, 2015 ... Key words: Cyprinus carpio, common carp, eggs, mycotal species, infections, ..... Woo PTK, Bruno DW (Eds.) Fish Diseases and Disorders. Viral, ... like organism developing on the eggs of pink salmon Oncorhynchus.

  12. Eto vam ne Dzheims Bond / Vincent Vega

    Index Scriptorium Estoniae

    Vega, Vincent


    Actionfilmi "Võimatu missioon" ("Mission : Impossible") järg "Võimatu Missioon 2 ("Mission : Impossible II") : režissöör John Woo : peaosaline ja produtsent Tom Cruise : Ameerika Ühendriigid 2000

  13. African Journal of Biotechnology - Vol 12, No 20 (2013)

    African Journals Online (AJOL)

    Rubisco activity and gene expression of tropical tree species under light stress · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Keum-Ah Lee, Seong Han Lee, Su Young Woo ...

  14. Prime Contract Awards by State or Country, Place and Contractor. Part 13 (New London, Ohio - Westerly, Rhode Island), FY1991 (United States)


    C .4uO > NMX jInI n-4 r- -4 >0a0 0a 0 X 11 M -4 it 000C000 00 000C>-4 0. on n0000 - -1 4D to "c0200 00O c > : Q 10 1(0 -4 I1 r- -q a)on Coo -4 r𔃼m00...o004 inn = In0 N -a 1 a (-4 gao LCao Wo LA4 0*v 0 Z2o0o000 ix N N. " 0 I (a0-4 N t I0) C.0C -JOC) Woo 4 -444 q0 0 1- Nr EU a (04 N aJO WOO 0.4 woo

  15. Resurfacing hemiarthroplasty compared to stemmed hemiarthroplasty for glenohumeral osteoarthritis

    DEFF Research Database (Denmark)

    Rasmussen, Jeppe V; Olsen, Bo S; Sorensen, Anne Kathrine


    PURPOSE: The aim of this study was to conduct a randomised, clinical trial comparing stemmed hemiarthroplasty and resurfacing hemiarthroplasty in the treatment of glenohumeral osteoarthritis. METHODS: A total of 40 shoulders (35 patients) were randomised to stemmed hemiarthroplasty or resurfacing...... hemiarthroplasty and evaluated three and 12 months postoperatively using the Constant-Murley score (CMS) and Western Ontario Osteoarthritis of the Shoulder (WOOS) index. RESULTS: There were no statistically significant differences in age, gender or pre-operative scores except for WOOS at baseline. Two patients...

  16. Stem-cell spin: Covering the Hwang-affair in Science and Nature

    DEFF Research Database (Denmark)

    Kjærgaard, Rikke Schmidt


    In 2006 the South Korean cloning expert Woo Suk Hwang was found guilty of fraud and scientific misconduct. The scandal was reaching far beyond Hwang’s own laboratory encompassing national pride, geopolitics and regional discussions of stem-cell research. But the HIn 2006 the South Korean cloning...... expert Woo Suk Hwang was found guilty of fraud and scientific misconduct. The scandal reached far beyond Hwang’s own laboratory, encompassing national pride, geopolitics and global discussions of stem-cell research. But the Hwang affair was also a case of fierce competition between two of the world...

  17. Seasonal Variation in Trypanosomosis Rates in Small Ruminants at ...

    African Journals Online (AJOL)

    Rev Dr Olaleye

    blood. The blood samples were kept cool by placing them in cold boxes containing ice packs after collection. Parasitological examination was done in the Laboratory using the haematocrit centrifugation technique, HCT (Woo, 1971), buffy coat method (BCM) (Murry et. al; 1977) and. Giemsa stained thin films made after BCM.

  18. A Framework for Interaction and Cognitive Engagement in Connectivist Learning Contexts (United States)

    Wang, Zhijun; Chen, Li; Anderson, Terry


    Interaction has always been highly valued in education, especially in distance education (Moore, 1989; Anderson, 2003; Chen, 2004a; Woo & Reeves, 2007; Wang, 2013; Conrad, in press). It has been associated with motivation (Mahle, 2011; Wen-chi, et al., 2011), persistence (Tello, 2007; Joo, Lim, & Kim, 2011), deep learning (Offir, et al.,…

  19. NeighbourWoods for Better Cities

    DEFF Research Database (Denmark)

    Konijnendijk, Cecil Cornelis; Schipperijn, Jasper Jan

    This publication aims to contribute to the development af NeighbourWoods through socially-inclusive planning, design and management. It presents experiences from an international project supported by the European Commission which evaluated and developed approaches and tools to assist NeighbourWoo...

  20. An Exploration of Multiple Channel Evaluations in Attributions of Deception. (United States)


    woo Id lit with11011 t lit’ d It ted i In Add flt lotia dcl In t foli! tidclt (le on loi it Ithioulgh socialit ivdl lv dit treit appear to dgrct, wi lIi...Specifically, a survey was designed for this purpose (Appendix B). The survey consisted of 12 statements, mostly political in nature, and allowed each

  1. Muusikauudiseid maailmast / Ia Remmel

    Index Scriptorium Estoniae

    Remmel, Ia, 1965-


    Lühisõnumeid maailmast: Suri Einojuhani Rautavaara. ECHO Klassiku 2017. aasta preemia saajad selgunud. Bachi haruldane käsikiri oksjonil. "Operalia 2016" võitjad on Keon-Woo Kim ja Elsa Dreisig. Shakespeare'i Globe asutas oma plaadimärgi. Sydney konkursi vitis vene pianist Andrei Gugnin. Noorel rootsi viiuldajal leping Deutsche Grammophoniga

  2. Anisotropic optical properties of ZnS thin films with zigzag structure

    Indian Academy of Sciences (India)


    Aug 18, 2017 ... shapes can be produced. In the earliest efforts .... Figure 2. (a) XRD patterns of ZnS films under different conditions .... are presented in figure 6a–c. In figure 6 ..... [13] Woo S-H and Hwangbo C K 2006 J. Korean Phys. Soc. 48.

  3. Studies of Giardia lamblia (United States)


    isoenzyme analysis of 19 axenic strains isolated from symptomatic and asymptomatic patients in Mexico . Trans. R. Soc. Trop. Med. Hyg. 83 : 644-646...antibody studies with agents of Varicella and Herpes Zoster propagated in vitro. Proe. Soc. Exptl. BioI. Med . 86 :7 89-794. Woo, P. and G.S. Panayi

  4. Artificial intelligence expert systems with neural network machine learning may assist decision-making for extractions in orthodontic treatment planning. (United States)

    Takada, Kenji


    New approach for the diagnosis of extractions with neural network machine learning. Seok-Ki Jung and Tae-Woo Kim. Am J Orthod Dentofacial Orthop 2016;149:127-33. Not reported. Mathematical modeling. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. Sounds Exaggerate Visual Shape (United States)

    Sweeny, Timothy D.; Guzman-Martinez, Emmanuel; Ortega, Laura; Grabowecky, Marcia; Suzuki, Satoru


    While perceiving speech, people see mouth shapes that are systematically associated with sounds. In particular, a vertically stretched mouth produces a /woo/ sound, whereas a horizontally stretched mouth produces a /wee/ sound. We demonstrate that hearing these speech sounds alters how we see aspect ratio, a basic visual feature that contributes…

  6. Kloonimiskuningas osutus tüssajaks / Arko Olesk

    Index Scriptorium Estoniae

    Olesk, Arko, 1981-


    Lõuna-Korea teadlane Hwang Woo-Suk astus möödunud aasta lõpus pettuses süüdistatuna tagasi Souli ülikooli professori kohalt, olles varem alusetult väitnud, et on saavutanud läbimurde geenitehnoloogias ning suudab tõhusalt tüvirakke luua

  7. Higher Education and Entrepreneurial Citizenship in Singapore (United States)

    Christensen, Soren


    Focusing on Singapore's "Global Schoolhouse" project, this article discusses how efforts to transform Singapore into a "world class" knowledge economy entail changes to the status of citizenship in Singapore. The project of wooing top foreign universities to Singapore is permeated with an entrepreneurial ideal of Singapore as…

  8. Academic Degradation and the Retreat of the Editors: Academic Irregularities and the Spreading of Academic Corruption from an Editor's Perspective (United States)

    Xun, Gong


    Against the backdrop of the grave academic crisis in China, editors have become the objects of wooing, favor-currying, connections-seeking, and collusions; they have been targeted for attacks, plots, extortions, and encroachments. Editing and publishing have become avenues for academic irregularities and academic corruption. Editors have the power…

  9. Plants' responses to drought and shade environments

    African Journals Online (AJOL)


    Among them, drought is widely known as the main factor that limits plants' growth, productivity and development (Reddy et al., 2004; Shao et al., 2008; Li et al., 2009). Recently, drought occured frequently all over the globe due to climate changes (Khaine and Woo, 2015). Light and shade are very important environements ...

  10. Neural Development in tsc2-Deficient Zebrafish (United States)


    the cells in this region normally give rise to forebrain and retina (Woo and Fraser, 1995). Analyses of chimeric embryos at 7.5 dpf revealed that...white matter. Green color is tissue autofluorescence ; blue is DAPI staining. P, pallium; Po, preoptic region; Sd, dorsal division of subpallium; Tve

  11. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Soo-Dong Woo1 Jae Young Choi2 Yeon Ho Je2 Byung Rae Jin3. Department of Plant Medicine, College of Agriculture, Life and Environment Sciences, Chungbuk National University, Cheongju 361-763, Korea; School of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Seoul ...

  12. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 32; Issue 4. Molecular cloning and expression of the C-terminus of spider flagelliform silk protein from Araneus ventricosus. Kwang Sik Lee Bo Yeon Kim Yeon Ho Je Soo Dong Woo Hung Dae Sohn Byung Rae Jin. Articles Volume 32 Issue 4 June 2007 pp 705-712 ...

  13. Molecular mechanism of methionine differentiation in high and low ...

    African Journals Online (AJOL)



    May 9, 2011 ... Key words: Maize, methionine, zein, storage protein, amino acid, real time PCR. INTRODUCTION ... programs should be started with main objectives to increase and ... (Woo et al., 2001), while beta zein have interaction with delta zein ... sion analysis of 27 kDa gamma zein and 16 kDa gamma zein, 22 kDa ...

  14. Brassia campestris L. ssp. chinensis L.var. utilis Tsen et Lee

    African Journals Online (AJOL)



    Dec 31, 2012 ... On the basis of morphological and cultural features, the pathogen ... Alternaria isolate from Purple-Caitai showed 99% identity with other ITS sequences of .... Cho KH, Park SH, Kim KT, Kim S, Kim JS, Park BS, Woo JG, Lee HJ.

  15. Expression of porcine myosin heavy chain 1 gene in Berkshire loins ...

    African Journals Online (AJOL)

    Expression of porcine myosin heavy chain 1 gene in Berkshire loins with a high pH24 value. Jin Hun Kang, Woo Young Bang, Eun Jung Kwon, Yong Hwa Lee, Da Hye Park, Eun Seok Cho, Min Ji Kim, Jong-Soon Choi, Hwa Chun Park, Beom Young Park, Chul Wook Kim ...

  16. Identification and chromosomal localization of repeat sequences ...

    Indian Academy of Sciences (India)


    woo BAC library containing a total of 150,000 clones with an average size of ... generate linkage maps of human and cattle as well as for other mammalian ..... gram, Rural Development Administration, Republic of Korea. We thank all our ...

  17. Public understanding: can we make an atom of difference?

    International Nuclear Information System (INIS)

    Harding, C.


    The Chairman of British Nuclear Fuels Limited proposes a fresh marketing approach for the image of nuclear power generation in the United Kingdom, in an attempt to woo public opinion. Openness and honesty are essential, and environmental issues, while important, should not be cynically exploited. The Visitors' Centre at Sellafield is cited as a good example of how this might be achieved. (UK)

  18. Outcome of Revision Shoulder Arthroplasty After Resurfacing Hemiarthroplasty in Patients with Glenohumeral Osteoarthritis

    DEFF Research Database (Denmark)

    Rasmussen, Jeppe V; Olsen, Bo S; Al-Hamdani, Ali


    hemiarthroplasty was 62 points (interquartile range, 40 to 88 points). Of the 80 cases that had follow-up, 33 (41%) had an unacceptable outcome, defined as a WOOS of ≤50 points. Of the 107 cases that required a revision surgical procedure, 11 arthroplasties (10%) required a further revision surgical procedure...

  19. Early Sámi visual artists - Western fine art meets Sámi culture

    Directory of Open Access Journals (Sweden)

    Tuija Hautala-Hirvioja


    Full Text Available Johan Turi (1854–1936, Nils Nilsson Skum (1872–1951 and John Savio (1902–1938 were among the first Sámi visual artists. The production of their art work occurred between the 1910s and the early 1950s. Sámi aesthetics had its basis in folklore, i.e., handicraft or duodji, which did not follow the principle of art for art’s sake but combined beauty and practicality. Art was part of community life. Not until the 1970s was the word daidda, which is Finnish in origin and which means “art”, adopted into the Sámi language. Turi and Skum became famous through their books. They drew and wrote in order to pass the traditional knowledge of their people on to succeeding generations. They also wanted to introduce Sámi life and culture to non-Sámi people. One typical feature of their work is that they depicted Sáminess in a realistic way and sought to strengthen and preserve the Sámi identity through their art. In Turi and Skum’s work, both the documentation of community life and their own personal expression were strongly present and equally important; for this reason their pictures and texts have both practical and aesthetic dimensions. They did not attend school and were self-taught artists. The third pioneer of Sámi visual arts was John Savio, who, unlike the other two, attended secondary school and studied visual arts both independently and under the guidance of a mentor. He expressively combined Western ways of depiction with Sámi subjects. My article examines what made these early Sámi artists change over from Sámi handicraft, duodji, to Western visual arts, how they used Western pictorial conventions in dealing with their Sámi subjects, and the significance of their art for Sámi identity and culture. They lived and worked under cross pressure: the first few decades of the 20th century were characterized by racial theories that denigrated Sámi people, and the period following World War II was marked by demands for

  20. The application of coronal scattering measurements to solar radio bursts

    International Nuclear Information System (INIS)

    Bradford, H.M.


    The interpretation of ground based observations of solar 'plasma frequency' radio bursts has been hampered in the past by an insufficient knowledge of coronal scattering by density inhomogeneities close to the Sun. Calculations based on measuurements of the angular broadening of natural radio sources, and Woo's 1975 measurement of the angular broadening of the telemetry carrier by Helios I near occultation (Woo, 1978), indicate that plasma frequency solar bursts should undergo considerable scattering, at least near the maximum of the sunspot cycle. The calculated displacements of the apparent positions of the bursts are about equal to the observed displacements which have been attributed to the bursts occurring in dense streamers. In order to obtain more scattering data close to the Sun, interferometer measurements of the angular broadening of spacecraft signals are planned, and the important contribution which could be made with large dishes is discussed. (Auth.)

  1. Patient-reported outcome and risk of revision after shoulder replacement for osteoarthritis

    DEFF Research Database (Denmark)

    Rasmussen, Jeppe V; Polk, Anne; Brorson, Stig


    PURPOSE: We used patient-reported outcome and risk of revision to compare hemiarthroplasty (HA) with total shoulder arthroplasty (TSA) and stemmed hemiarthroplasty (SHA) with resurfacing hemiarthroplasty (RHA) in patients with glenohumeral osteoarthritis. PATIENTS AND METHODS: We included all...... of presentation, the raw scores were converted to a percentage of the maximum score. Revision rates were calculated by checking reported revisions to the DSR until December 2011. WOOS and risk of revision were adjusted for age, sex, previous surgery, and type of osteoarthritis. RESULTS: There were 113 TSAs...... and 1096 HAs (837 RHAs and 259 SHAs). Patients treated with TSA generally had a better WOOS, exceeding the predefined minimal clinically important difference, at 1 year (mean difference 10, p

  2. Outcome, revision rate and indication for revision following resurfacing hemiarthroplasty for osteoarthritis of the shoulder

    DEFF Research Database (Denmark)

    Rasmussen, J V; Polk, A; Sorensen, A K


    In this study, we evaluated patient-reported outcomes, the rate of revision and the indications for revision following resurfacing hemiarthroplasty of the shoulder in patients with osteoarthritis. All patients with osteoarthritis who underwent primary resurfacing hemiarthroplasty and reported...... to the Danish Shoulder Arthroplasty Registry (DSR), between January 2006 and December 2010 were included. There were 772 patients (837 arthroplasties) in the study. The Western Ontario Osteoarthritis of the Shoulder (WOOS) index was used to evaluate patient-reported outcome 12 months (10 to 14) post......-operatively. The rates of revision were calculated from the revisions reported to the DSR up to December 2011 and by checking deaths with the Danish National Register of Persons. A complete questionnaire was returned by 688 patients (82.2%). The mean WOOS was 67 (0 to 100). A total of 63 hemiarthroplasties (7...

  3. The Danish Shoulder Arthroplasty Registry: clinical outcome and short-term survival of 2,137 primary shoulder replacements

    DEFF Research Database (Denmark)

    Rasmussen, Jeppe; Jakobsen, John; Brorson, Stig


    The Danish Shoulder Arthroplasty Registry (DSR) was established in 2004. Data are reported electronically by the surgeons. Patient-reported outcome is collected 10-14 months postoperatively using the Western Ontario osteoarthritis of the shoulder index (WOOS). 2,137 primary shoulder arthroplasties...... (70% women) were reported to the registry between January 2006 and December 2008. Mean age at surgery was 69 years (SD 12). The most common indications were a displaced proximal humeral fracture (54%) or osteoarthritis (30%). 61% were stemmed hemiarthroplasties, 28% resurfacing hemiarthroplasties, 8......% reverse shoulder arthroplasties, and 3% total arthroplasties. Median WOOS was 59% (IQR: 37-82). 5% had been revised by the end of June 2010. The most frequent indications for revision were dislocation or glenoid attrition....

  4. Army Profession: How Effective Leadership Reinforces an Ethos of Trust (United States)


    34 Won-Woo Park and Sangyun Kim, “The Need of Leader-Subordinate Reciprocal Dyadic Trust to Build the Subordinate’s Trust in the...Behavior: Communication and Understanding in Relationships, eds. A. G. Athos and J. J. Gabarro (Englewood Cliffs, NJ: Prentice-Hall, 1978), 290-303...the trust recommendations were senior Army leader strategic communication programs, trust development in doctrine, and making trust a topic for all

  5. BCP selector valves and limit switches

    International Nuclear Information System (INIS)

    Rippy, G.L.


    This Acceptance Test Procedure (ATP) has been prepared to demonstrate that the Electrical/Instrumentation systems for the BCP stream function as required by project criteria. Specifically, the test will verify the operation of the solenoid valves and associated limit switches installed for the BCP portion of W-OO7H. This equipment is part of the B-Plant Process Condensate Treatment Facility

  6. A Continuum Mechanical Approach to Geodesics in Shape Space (United States)


    mean curvature flow equation. Calc. Var., 3:253–271, 1995. [30] Siddharth Manay, Daniel Cremers , Byung-Woo Hong, Anthony J. Yezzi, and Stefano Soatto...P. W. Michor and D. Mumford. Riemannian geometries on spaces of plane curves. J. Eur. Math. Soc., 8:1–48, 2006. 37 [33] Peter W. Michor, David ... Cremers . Shape matching by variational computation of geodesics on a manifold. In Pattern Recognition, LNCS 4174, pages 142–151, 2006. [38] P

  7. Nonequilibrium Phase Transitions Associated with DNA Replication (United States)


    polymerases) catalyzing the growth of a DNA primer strand (the nascent chain of nucleotides complementary to the template strand) based on the Watson ...the fraction (error rate) of monomers for which y, where y is the correct Watson - Crick complementary base of , can be obtained by ¼ X...Nonequilibrium Phase Transitions Associated with DNA Replication Hyung-June Woo* and Anders Wallqvist Biotechnology High Performance Computing

  8. Improving Protection against Viral Aerosols Through Development of Novel Decontamination Methods and Characterization of Viral Aerosol (United States)


    mixing DAS (Granular form, Sigma–Aldrich, P9265) with deionized (DI) water and then cooked at 95 o C for 2 hrs, as described in Song et al. (2009...from sneezing or coughing. Details of the recipe for artificial saliva are reported in Woo et al. (2010). Experimental Method A schematic diagram of...microwave. ** Polyacrylonitrile ( PAN ) and cross-linked PAN nanofiber filter were tested and the

  9. Index of Submarine Medical Officer’s Qualification Theses 1944-1974 (United States)



  10. Omega-3 fatty acid supplementation can improve both symptoms and signs of dry eye disease


    Kwon,Jae-Woo; Han,Sang Beom


    Jae-Woo Kwon,1 Sang Beom Han2 1Department of Internal Medicine, 2Department of Ophthalmology, Kangwon National University Hospital, Kangwon National University Graduate School of Medicine, Chuncheon, South Korea We read with great interest the article by Gatell-Tortajada1 entitled “Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prosp...

  11. DARPA Quantum Network Testbed (United States)


    Antonio Bovino, Pietro Varisco, Anna Maria Colla, Giuseppe Castagnoli, Giovanni Di Giuseppe and Alexander V. Sergienko “Effective Fiber-Coupling of...Giovanni Di Giuseppe Brian Imhausen Harvard University Teammate John Myers Tai Wu Leo Donnelly NIST Teammate Sae Woo Nam Bob Schwall Robert...A. M. Colla, G. Castagnoli, G. Di Giuseppe, and A. V. Sergienko, “Practical Quantum Key Distribution Using Polarization Entangled States

  12. Microwave-Irradiation-Assisted HVAC Filtration for Inactivation of Viral Aerosols (Postprint) (United States)


    Baggiani, A. and Senesi, S. (2004). Effect of Microwave Radiation on Bacillus subtilis Spores . J. Appl. Microbiol. 97: 1220–1227. Damit, B., Lee, C.N...AFRL-RX-TY-TP-2012-0020 MICROWAVE-IRRADIATION-ASSISTED HVAC FILTRATION FOR INACTIVATION OF VIRAL AEROSOLS POSTPRINT Myung-Heui Woo and...12-APR-2011 -- 11-DEC-2011 Microwave Irradiation-Assisted HVAC Filtration for Inactivation of Viral Aerosols (POSTPRINT) FA8650-06-C-5913 0602102F

  13. Boomers versus Millennials: Online Media Influence on Media Performance and Candidate Evaluations


    Terri Towner; Caroline Lego Munoz


    Facebook posts, YouTube videos, tweets and wooing political bloggers have become standard practice in marketing political campaigns. Research has demonstrated the effect of new media on a host of politically-related behavior, including political participation, knowledge acquisition, group formation and self-efficacy. Yet, issues related to media trust, media performance and candidate evaluations have not been fully explored. In addition, much of the political marketing research looks exclusiv...

  14. A General Explanation-Based Learning Mechanism and Its Application to Narrative Understanding. (United States)


    Forbus. and Alan Frisch for also serving on my inal committee and providing helpful comments. . .- Woo- Kyoung Ahn for being a great cognitive science...up the Michelin guide and got in her car. When the system processes the action that Willa has picked up the Michelin guide. it considers that tae next...following is the new Kveah narrative written by one subject in the instance group. Bill. Kim . John and Marv were all business associates. Bill wanted

  15. JPRS Report, Near East & South Asia, India (United States)


    short-term gains. It would sustained minor injuries . One of the ULFA militants was call for quite a change in attitude on the part of Indian also injured...central committee who assist the politburo. They are Mr woo him into the cabinet since his mentor Vasantdada Prakash Karat and Mr Sitaram Yachuri from Delhi...The market share of the Indian yarn was too low for it REP licence system. Success in eliminating quantity to cause material injury . restrictions will

  16. Operation CROSSROADS-1946 (United States)


    uate and reduce nonradiological hazards to boarding parties. Hazards thdt had to be addressed included falling objects, slippery decks, weak ladders...8217., Woo a 001401 0 *#fgay It, 1 At 1 11-101-46 1, 11I...’ WO, Wal.l g’".l Will I I IL) A’e , elm ..l O f i -o S itlitim 1 t)aIII’) 11- 11.0m 11r tl ai f If

  17. The woollen system- development and basic principles

    CSIR Research Space (South Africa)

    Van der Merwe, JP


    Full Text Available .................. ..................... 4.9 Fibre transfer between swift and doffer ..................................... 4.10 WooUencondensing ............................ 4.10.1 Ring doffer condensers 4.10.2 Tape condensers.... For the dusting or shaking process a double-cylinder opening machine is often used, as shown in Figure 2. Sand, dirt and dust are removed by the rotating spiked beaters which heat the wool against the screens at the bottom of the machine. Fig. 2 - Doubk...

  18. Navy Carrier Battle Groups: The Structure and Affordability of the Future Force (United States)


    Embassy, Tokyo, Japan U.S. Embassy, Kuala Lumpur, Malaysia U.S. Embassy, Singapore U.S. Embassy, Bangkok, Thailand U.S. Embassy, Ankara, Turkey U.S...Ministry of Foreign Affairs Malaysia Institute of Strategic and International Studies, Kuala Lumpur University of Malaysia , Kuala Lumpur Singapore...1591 1992 Calendar year Mediterraniean Sao - Western Pacific Ocean " Nestl Indian 0asan/Arabian Seam WOO I Total Note: Because theso deployment levels


    Directory of Open Access Journals (Sweden)

    G. Bitelli


    Full Text Available The present study aims to demonstrate the usefulness of GIS to support archive searches and historical studies (e.g. related to industrial archaeology, in the case of an ancient channel for mill powering near Cesena (Emilia-Romagna, Italy, whose history is weaved together with the history of the Compagnia dei Molini di Cesena mill company, the most ancient limited company in Italy. Several historical maps (about 40 sheets in total inherent the studied area and 80 archive documents (drawings, photos, specifications, administrative acts, newspaper articles, over a period of more than 600 years, were collected. Once digitized, historical maps were analysed, georeferenced and mosaicked where necessary. Subsequently, in all the maps the channel with its four mills and the Savio river were vectorized. All the additional archive documents were digitized, catalogued and stored. Using the QGIS open source platform, a Historical GIS was created, encompassing the current cartographic base and all historical maps, with their vectorized elements; each archive document was linked to the proper historical map, so that the document can be immediately retrieved and visualized. In such a HGIS, the maps form the base for a spatial and temporal navigation, facilitated by a specific interface; the external documents linked to them complete the description of the represented elements. This simple and interactive tool offers a new approach to archive searches, as it allows reconstruction in space and time of the evolution of the ancient channel and the history of this important mill company.

  20. Post-death cloning of endangered Jeju black cattle (Korean native cattle): fertility and serum chemistry in a cloned bull and cow and their offspring. (United States)

    Kim, Eun Young; Song, Dong Hwan; Park, Min Jee; Park, Hyo Young; Lee, Seung Eun; Choi, Hyun Yong; Moon, Jeremiah Jiman; Kim, Young Hoon; Mun, Seong Ho; Oh, Chang Eon; Ko, Moon Suck; Lee, Dong Sun; Riu, Key Zung; Park, Se Pill


    To preserve Jeju black cattle (JBC; endangered native Korean cattle), a pair of cattle, namely a post-death cloned JBC bull and cow, were produced by somatic cell nuclear transfer (SCNT) in a previous study. In the present study, we examined the in vitro fertilization and reproductive potentials of these post-death cloned animals. Sperm motility, in vitro fertilization and developmental capacity were examined in a post-death cloned bull (Heuk Oll Dolee) and an extinct nuclear donor bull (BK94-13). We assessed reproductive ability in another post-death cloned cow (Heuk Woo Sunee) using cloned sperm for artificial insemination (AI). There were no differences in sperm motility or developmental potential of in vitro fertilized embryos between the post-death cloned bull and its extinct nuclear donor bull; however, the embryo development ratio was slightly higher in the cloned sperm group than in the nuclear donor sperm group. After one attempt at AI, the post-death cloned JBC cow became pregnant, and gestation proceeded normally until day 287. From this post-death cloned sire and dam, a JBC male calf (Heuk Woo Dolee) was delivered naturally (weight, 25 kg). The genetic paternity/maternity of the cloned JBC bull and cow with regard to their offspring was confirmed using International Society for Animal Genetics standard microsatellite markers. Presently, Heuk Woo Dolee is 5 months of age and growing normally. In addition, there were no significant differences in blood chemistry among the post-death cloned JBC bull, the cow, their offspring and cattle bred by AI. This is the first report showing that a pair of cattle, namely, a post-death cloned JBC bull and cow, had normal fertility. Therefore, SCNT can be used effectively to increase the population of endangered JBC.

  1. The use of wood waste for energy production

    International Nuclear Information System (INIS)

    Karlopoulos, E.; Pavloudakis, F.


    The paper presents some technical aspects and management issues of wood waste reuse end disposal. It refers to the Greek and European legislation which determines the framework for rational and environmental friendly practices for woos waste management. It refers also to the wood waste classification systems and the currently applied methods of wood waste disposal and reuse. Emphasis is given to the wood waste-to-energy conversion system, particularly to the pretreatment requirements, the combustion techniques, and the environmental constrains. Finally, the decision making process for the investments in the wood waste firing thermal units is discussed

  2. JPRS Report, Near East & South Asia, Israel (United States)


    parties it tried to woo into a coalition last Kohen didn’t care about the brand name. She had just year. In the end, the Likud’s offers won the day, actually being Therefore, his depiction as a martyr, a victim, and an conducted among the Arabs themselves, and its peak underdog is nonsense...the army and The group was housed in buildings in an abandoned one of them was a combat officer in the Armoured military camp from the period of the

  3. Advanced Technology for Ultra-Low Power System-on-Chip (SoC) (United States)


    was proposed for lower power applications with Ioff=10pA/μm and VDD=0.5V. In this project, the optimized structure shows great potential in both Lg...AFRL-RY-WP-TR-2017-0115 ADVANCED TECHNOLOGY FOR ULTRA-LOW POWER SYSTEM-ON-CHIP (SoC) Jason Woo, Weicong Li, and Peng Lu University of California...September 2015 – 31 March 2017 4. TITLE AND SUBTITLE ADVANCED TECHNOLOGY FOR ULTRA-LOW POWER SYSTEM-ON- CHIP (SoC) 5a. CONTRACT NUMBER FA8650-15-1-7574 5b

  4. Biological age as a health index for mortality and major age-related disease incidence in Koreans: National Health Insurance Service – Health screening 11-year follow-up study


    Kang,Young Gon; Suh,Eunkyung; Lee,Jae-woo; Kim,Dong Wook; Cho,Kyung Hee; Bae,Chul-Young


    Young Gon Kang,1 Eunkyung Suh,2 Jae-woo Lee,3 Dong Wook Kim,4 Kyung Hee Cho,5 Chul-Young Bae1 1Department of R&D, MediAge Research Center, Seongnam, Republic of South Korea; 2Department of Family Medicine, College of Medicine, CHA University, Chaum, Seoul, Republic of South Korea; 3Department of Family Medicine, College of Medicine, Chungbuk National University, Cheongju, Republic of South Korea; 4Department of Policy Research Affairs, National Health Insurance Service Ilsan Hospital...

  5. Needs Assessment to Define the Training Requirements for a Basic Skills Education Program (BSEP) Curriculum Development. Revision. (United States)


    MW1 zm~woo 0 /4 ==W a.. w Z 3 OU. 3 C M p. i 40..U - w W -- l2 L ccU= 1 0.-- r U)_.O I- ~ I-1 ZI 4 C :x U z WX-L U ZZ 4 0Z LL - ac z3 _ uj.- 0 ~ f3 LU D...opeC/cdswoeap e to the TPA-2 form and remort,-a:c 70- :o -e 7P,-3 and Knowledge Analysis formns and reports. To acca -%-- Ce :ns cn’-r’ge, task anal’,s

  6. Linkage relationship between semi-dwarfing gene sd-1 and gene for grain shattering in rice

    International Nuclear Information System (INIS)

    Oba, S.; Kikuchi, F.


    Full text: Most semidwarf rice cultivars carry the same gene sd-1. We observed an association between semi-dwarfness and grain shattering in isogenic lines carrying sd-1 from different sources in the background of the Japanese tall cultivar 'Norin 28'. The shattering was found to be caused by a single recessive gene, sh-2, linked to the sd-1 locus. The shattering gene seems to have been transmitted to many semi-dwarf cultivars together with sd-1, not only from 'Dee-geo-woo-gen' but also from the indica-cultivar 'Ai-jio-nan-te' and the japonica cultivar 'Shiranui'. (author)

  7. Seks ja töö / Andres Maimik

    Index Scriptorium Estoniae

    Maimik, Andres, 1970-


    Filmifestivalil "Armastus ja Anarhia" ("Rakkautta & Anarkiaa") 21.09.- 01.10. nähtud filmidest : Rosa von Praudheimi eluloofilm "Einstein of Sex", Julien Temple dokumentaalfilm "The Filth and the Fury", Virginie Despentes ja Coralie Trinh Thi "Baise moi!" ("Vägista mind!"), Catherine Breillat "Une vraie Jeune Fille" ("Päris noor tüdruk"), Francois Ozoni Rainer Werner Fassbinderi näidendi järgi tehtud film "Gouttes d'eau sur pierres brulantes" ("Veetilgad põlevatel kividel"), Jang Sun Woo "Gojimal" ("Valed") ja Laurent Cantet' "Ressources humaines" ("Inimressursid")

  8. Ospreys Use Bald Eagle Nests in Chesapeake Bay Area


    Therres, Glenn D.; Chandler, Sheri K.


    Ospreys (Pandion haliaetus) and Bald Eagles (Haliaeetus leucocephalus) share similar breeding habitat in the Chesapeake Bay area and elsewhere. The nests of these species are similar in size and appearance. Ospreys typically build large stick nests in dead trees or on man-made structures (C.J. Henny et al. 1974, Chesapeake Sci. 15:125-133; A.F. Poole 1989, Ospreys: a natural and unnatural history, Cambridge Univ. Press, NY), while Bald Eagles usually build larger nests in live trees (P.B. Woo...

  9. Pink electrons, anyone?

    International Nuclear Information System (INIS)

    McCaughey, John.


    The deregulated electric power industry in the United States is undergoing a radical change in marketing emphasis more familiar to consumers of branded products such as soft drinks. In attempts to woo customers from other companies, utilities are beginning to market a ''company image'' offering lower prices, better products (i.e. other household services such as telephone and cable television) and improved provision levels of customer services. The price of the product, in this case electric power, has been shown to be much more likely to persuade a consumer to shift supplier than any existing level of customer satisfaction. (UK)

  10. Electronic Materials and Applications 2014 (Abstracts) (United States)


    electric fatigue at TU Darmstadt (SFB595) . In Germany he served the Deutsche Forschungsgemeinschaft (DFG) a four-year term as speaker of the review...epitaxial La-doped PZT films at low concentrations of La-doping M. Hordagoda*, D. Mukherjee, University of South Florida, USA; D. Ghosh, J. Jones...S1-P001-2014) Effect of viscosity and thickness in PZT - PZNN tape casting process for energy harvesting system D. Song*, M. Woo, D. Cho, T. Sung

  11. Research ethics and lessons from Hwanggate: what can we learn from the Korean cloning fraud? (United States)

    Saunders, R; Savulescu, J


    In this review of the Korean cloning scandal involving Woo-Suk Hwang, the nature of the disaster is documented and reasons why it occurred are suggested. The general problems it raises for scientific research are highlighted and six possible ways of improving practice are offered in the light of this case: (1) better education of science students; (2) independent monitoring and validation; (3) guidelines for tissue donation for research; (4) fostering of debate about ethically contentious research in science journals; (5) development of an international code of ethical research practice; (6) fostering of public involvement in ethical review and debate through the web.

  12. Korean Reunification: The Implications for Regional Security (United States)


    But this conflict was caused by external factors. In reality it is a combined internal and external problem. 10 Ibid., pp. 208-209, King Sejong and...was Ancient Chosen which was led by the legendary founder King Tan’gun- Wanggom. He established a tribal country called Kochoson in 4 Han, Woo-Keun...During the Warring period in China, between the 6th century and 221 B.C., Kochoson confronted several ancient Chinese states, such as Yen( King Chao 312-279

  13. Pain: a distributed brain information network?

    Directory of Open Access Journals (Sweden)

    Hiroaki Mano


    Full Text Available Understanding how pain is processed in the brain has been an enduring puzzle, because there doesn't appear to be a single "pain cortex" that directly codes the subjective perception of pain. An emerging concept is that, instead, pain might emerge from the coordinated activity of an integrated brain network. In support of this view, Woo and colleagues present evidence that distinct brain networks support the subjective changes in pain that result from nociceptive input and self-directed cognitive modulation. This evidence for the sensitivity of distinct neural subsystems to different aspects of pain opens up the way to more formal computational network theories of pain.

  14. Research Misconduct—Definitions, Manifestations and Extent

    Directory of Open Access Journals (Sweden)

    Lutz Bornmann


    Full Text Available In recent years, the international scientific community has been rocked by a number of serious cases of research misconduct. In one of these, Woo Suk Hwang, a Korean stem cell researcher published two articles on research with ground-breaking results in Science in 2004 and 2005. Both articles were later revealed to be fakes. This paper provides an overview of what research misconduct is generally understood to be, its manifestations and the extent to which they are thought to exist.

  15. Fatigue life of automotive rubber jounce bumper

    International Nuclear Information System (INIS)

    Sidhu, R S; Ali, Aidy


    It is evident that most rubber components in the automotive industry are subjected to repetitive loading. Vigorous research is needed towards improving the safety and reliability of the components. The study was done on an automotive rubber jounce bumper with a rubber hardness of 60 IRHD. The test was conducted in displacement-controlled environment under compressive load. The existing models by Kim, Harbour, Woo and Li were adopted to predict the fatigue life. The experimental results show strong similarities with the predicted models.

  16. Pharmacokinetic and bioequivalence study of a telmisartan/S-amlodipine fixed-dose combination (CKD-828) formulation and coadministered telmisartan and S-amlodipine in healthy subjects


    Kang,Woo Youl; Seong,Sook Jin; Ohk,Boram; Gwon,Mi-Ri; Kim,Bo Kyung; La,Sookie; Kim,Hyun-Ju; Cho,Seungil; Yoon,Young-Ran; Yang,Dong Heon; Lee,Hae Won


    Woo Youl Kang,1,2,* Sook Jin Seong,1,* Boram Ohk,1,2 Mi-Ri Gwon,1,3 Bo Kyung Kim,1,2 Sookie La,4 Hyun-Ju Kim,3 Seungil Cho,1 Young-Ran Yoon,1,2 Dong Heon Yang,5 Hae Won Lee1 1Clinical Trial Center, Kyungpook National University Hospital, Daegu, Republic of Korea; 2Department of Biomedical Science, BK21 Plus KNU Bio-Medical Convergence Program for Creative Talent, Kyungpook National University Graduate School, Daegu, Republic of Korea; 3Department of Molecular Medicine, Cell and Matrix Resear...

  17. Electric Power Research in 1991

    International Nuclear Information System (INIS)


    This book of contents are a study of desalination by Kim, Young Bu, a study on efficiency test for nuclear power security by Jo, Sung Je; Ann, Nam Sung; Kim, Ho Gi, augmentation of EMS and RYU by Jung, Tae Hoe; Shin, Young Chuel, research on application for electric cars by Yu, Ann Gue, practical use oft robot for nuclear industry by Woo, He Gone; Shin, Hen Beom, a study on the characteristics of coolant structure in generator by Choi, Beng Hwan; Song, Young Chel; Kim, Jong Hark, and research of penetration rate of appliances by Park, Hong Ho; Kim, Beng Cheal; Kim, Dong Hwen.

  18. X-Ray Absorption Spectroscopy of Uranium Dioxide

    Energy Technology Data Exchange (ETDEWEB)

    Tobin, J G


    After the CMMD Seminar by Sung Woo Yu on the subject of the x-ray spectroscopy of UO2, there arose some questions concerning the XAS of UO2. These questions can be distilled down to these three issues: (1) The validity of the data; (2) The monchromator energy calibration; and (3) The validity of XAS component of the figure shown. The following will be shown: (1) The data is valid; (2) It is possible to calibrate the monchromator; and (3) The XAS component of the above picture is correct. The remainder of this document is in three sections, corresponding to these three issues.

  19. Modulation of Estrogen-Depurinating DNA Adducts by Sulforaphane for Breast Cancer (United States)


    system in cancers: stress response and anabolic metabolism. Front. Oncol., 2, 200. doi: 10.3389/ fonc.2012.00200. 20. Agyeman,S.A. et  al. ( science education and young scientists. We look forward to working with you. Sincerely, Chuck  37 From: "Gary A. Lorigan...Drosophila," by Ki Moon Seong, Mira Yu, Kyu-Sun Lee, Young Woo Jin and Kyung J. Min, and for taking the time and effort to review this manuscript. Best

  20. Effects of adding nano-clay (montmorillonite) on performance of polyvinyl acetate (PVAc) and urea-formaldehyde (UF) adhesives in Carapa guianensis, a tropical species


    Rodríguez-Zúñiga, Ana; Vega-Baudrit, José; Alvarez, Vera; Moya-Roque, Roger

    2015-01-01 The aim of this study was to improve the bond strength resistance of polyvinyl acetate (PVAc) and urea-formaldehyde (UF) adhesives modified with nano-clay (montmorillonite) with a tropical species of wood known to exhibit adhesion related problems. These adhesives were evaluated with 1.0 and 1.5 wt% nano-clay concentrations with lap shear strength (SS), and the percentage of woo...

  1. Characterization of Si(100) homoepitaxy grown in the STM at low temperatures

    Energy Technology Data Exchange (ETDEWEB)

    Grube, H. (Holger); Brown, G. W. (Geoffrey W.); Pomeroy, J. M. (Joshua M.); Hawley, M. E. (Marilyn E.)


    We explore the growth of low-temperature bulk-like Si(100) homoepitaxy with regard to microscopic surface roughness and defects We characterize films grown at different temperatures up to 500K in-situ by means of an effusion cell added to our UHVSTM. The development of novel architectures for future generation computers calls for high-quality homoepitaxial (WOO) grown at low temperature. Even though Si(100) can be grown crystalline up to a limited thickness: the microstructure reveals significant small-scale surface roughness and defects specific to low-temperature growth. Both can he detrimental to fabrication and operation of small-scale electronic devices.

  2. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 7. Fairlane Gear, Incorporated-General Fiberglass Fabricators. (United States)


    n " L(140(00 0 ( -00 (D -0 -i- F- C") (.1 I-- (0(0LJ I jInI x I.( < .41 000000000 0000 -100000 -10000 woo0 (0 00 000 0L j0 0000 I( < 4 InO 0000000...44 0 NO "(00-40-4_-4 MD -t ONj I4 NI" 000 ZO 0CD00) 00 (0 woo w0-4000000 F-0 GAO 0-14 (𔃾 00 0 0Cm) z1- 4 < Cm) I -in inin -0 01-(0 (00 01 rC- Cm) IC...I I at % - * 0- 1 02-lZ I Lw c4 r 4 4 jIN CJI-4 JINNNinN -tr(jJNM JINI #NI NINN -JIACINjNN NC\\N--INNN NN-4NN INIJ--N(, >WI -,I - - - - - nC lI MIIr)" l

  3. Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 12 (McFadden Jimmy, Portugal - NCR Japan LTD, Japan), FY1991 (United States)


    co0 Z1--.-0) ) Mm𔄁’ -4-4 0- HM. I 0O-4 H 0r- 01r- 01r- 01-, 0 000Cl0 C 1 -4 xo)0) -I qt4 od w -4 HO 00 0~ .0 00 Wix wOC L44 WJOU WM WOO IL H I0-4 H1...1 1000U -JO -JO -j 0CO4O .-. *O 2 2 0 0 0 Uf C 13 (N if wOO cW c.0OOL . O WO W’-- Lj4 L1.000 WeB $- wi - 3-0 - W0 U a 03 ILN (L 0.- CL- CL In0h...0 0 0 0 0 0 -400c -40 -40 m"- r.00 4N10 .4. 1 ge4 63 1I I 3 I I I 1- 3 60 000 0 00 0* W2 0 In 10 6 LUi I WIX >0 6 .- i.4 4 4 4 .4-4_ 4 ._4-IN -iN -IN

  4. Web-of-Objects (WoO)-based context aware emergency fire management systems for the Internet of Things. (United States)

    Shamszaman, Zia Ush; Ara, Safina Showkat; Chong, Ilyoung; Jeong, Youn Kwae


    Recent advancements in the Internet of Things (IoT) and the Web of Things (WoT) accompany a smart life where real world objects, including sensing devices, are interconnected with each other. The Web representation of smart objects empowers innovative applications and services for various domains. To accelerate this approach, Web of Objects (WoO) focuses on the implementation aspects of bringing the assorted real world objects to the Web applications. In this paper; we propose an emergency fire management system in the WoO infrastructure. Consequently, we integrate the formation and management of Virtual Objects (ViO) which are derived from real world physical objects and are virtually connected with each other into the semantic ontology model. The charm of using the semantic ontology is that it allows information reusability, extensibility and interoperability, which enable ViOs to uphold orchestration, federation, collaboration and harmonization. Our system is context aware, as it receives contextual environmental information from distributed sensors and detects emergency situations. To handle a fire emergency, we present a decision support tool for the emergency fire management team. The previous fire incident log is the basis of the decision support system. A log repository collects all the emergency fire incident logs from ViOs and stores them in a repository.

  5. Web-of-Objects (WoO-Based Context Aware Emergency Fire Management Systems for the Internet of Things

    Directory of Open Access Journals (Sweden)

    Zia Ush Shamszaman


    Full Text Available Recent advancements in the Internet of Things (IoT and the Web of Things (WoT accompany a smart life where real world objects, including sensing devices, are interconnected with each other. The Web representation of smart objects empowers innovative applications and services for various domains. To accelerate this approach, Web of Objects (WoO focuses on the implementation aspects of bringing the assorted real world objects to the Web applications. In this paper; we propose an emergency fire management system in the WoO infrastructure. Consequently, we integrate the formation and management of Virtual Objects (ViO which are derived from real world physical objects and are virtually connected with each other into the semantic ontology model. The charm of using the semantic ontology is that it allows information reusability, extensibility and interoperability, which enable ViOs to uphold orchestration, federation, collaboration and harmonization. Our system is context aware, as it receives contextual environmental information from distributed sensors and detects emergency situations. To handle a fire emergency, we present a decision support tool for the emergency fire management team. The previous fire incident log is the basis of the decision support system. A log repository collects all the emergency fire incident logs from ViOs and stores them in a repository.

  6. Web-of-Objects (WoO)-Based Context Aware Emergency Fire Management Systems for the Internet of Things (United States)

    Shamszaman, Zia Ush; Ara, Safina Showkat; Chong, Ilyoung; Jeong, Youn Kwae


    Recent advancements in the Internet of Things (IoT) and the Web of Things (WoT) accompany a smart life where real world objects, including sensing devices, are interconnected with each other. The Web representation of smart objects empowers innovative applications and services for various domains. To accelerate this approach, Web of Objects (WoO) focuses on the implementation aspects of bringing the assorted real world objects to the Web applications. In this paper; we propose an emergency fire management system in the WoO infrastructure. Consequently, we integrate the formation and management of Virtual Objects (ViO) which are derived from real world physical objects and are virtually connected with each other into the semantic ontology model. The charm of using the semantic ontology is that it allows information reusability, extensibility and interoperability, which enable ViOs to uphold orchestration, federation, collaboration and harmonization. Our system is context aware, as it receives contextual environmental information from distributed sensors and detects emergency situations. To handle a fire emergency, we present a decision support tool for the emergency fire management team. The previous fire incident log is the basis of the decision support system. A log repository collects all the emergency fire incident logs from ViOs and stores them in a repository. PMID:24531299

  7. Effect of self-interstitial diffusion anisotropy in electron-irradiated zirconium: A cluster dynamics modeling

    International Nuclear Information System (INIS)

    Christien, F.; Barbu, A.


    A model based on the cluster dynamics approach was proposed in [A. Hardouin Duparc, C. Moingeon, N. Smetniansky-de-Grande, A. Barbu, J. Nucl. Mater. 302 (2002) 143] to describe point defect agglomeration in metals under irradiation. This model is restricted to materials where point defect diffusion is isotropic and is thus not applicable to anisotropic metals such as zirconium. Following the approach proposed by Woo [C.H. Woo, J. Nucl. Mater. 159 (1988) 237], we extended in this work the model to the case where self-interstitial atoms (SIA) diffusion is anisotropic. The model was then applied to the loop microstructure evolution of a zirconium thin foil irradiated with electrons in a high-voltage microscope. First, the inputs were validated by comparing the numerical results with Hellio et al. experimental results [C. Hellio, C.H. de Novion, L. Boulanger, J. Nucl. Mater. 159 (1988) 368]. Further calculations were made to evidence the effect of the thin foil orientation on the dislocation loop microstructure under irradiation. The result is that it is possible to reproduce for certain orientations the 'unexpected' vacancy loop growth experimentally observed in electron-irradiated zirconium [M. Griffiths, M.H. Loretto, R.E. Sallmann, J. Nucl. Mater. 115 (1983) 313; J. Nucl. Mater. 115 (1983) 323; Philos. Mag. A 49 (1984) 613]. This effect is directly linked to SIA diffusion anisotropy

  8. Uncertainty propagation analysis applied to volcanic ash dispersal at Mt. Etna by using a Lagrangian model (United States)

    de'Michieli Vitturi, Mattia; Pardini, Federica; Spanu, Antonio; Neri, Augusto; Vittoria Salvetti, Maria


    variance of the grain size distribution at various distances from the source, both in air and on the ground. In particular, results highlighted the strong reduction of the uncertainty ranges of the mean and variance of the grain-size distribution with increasing distance from source and the significant control of particle sphericity on the dispersal process. References M de'Michieli Vitturi, A Neri, T Esposti Ongaro, S Lo Savio, and E Boschi. Lagrangian modeling of large volcanic particles: Application to Vulcanian explosions. Journal of Geophysical Research: Solid Earth (1978-2012), 115(B8), 2010.

  9. Economic cycles and their synchronization: Spectral analysis of macroeconomic series from Italy, The Netherlands, and the UK (United States)

    Sella, Lisa; Vivaldo, Gianna; Ghil, Michael; Groth, Andreas


    economy of a country: Hallegatte and Ghil (Ecol. Econ., 2008) have shown that the presence of business cycles modifies substantially this impact with respect to their impact on an economy in or near equilibrium. The present work concludes with a study of the synchronization of economic fluctuations, which follows a similar study of macroeconomic indicators for the United States, presented in a nearby poster. Since business cycles are not country-specific phenomena, but show common characteristics across countries, our aim is to uncover hidden global behavior across the European economies (cf. Mazzi and Savio, Macmillan, 2006).

  10. Revision of Eucorydia Hebard, 1929 from China, with notes on the genus and species worldwide (Blattodea, Corydioidea, Corydiidae) (United States)

    Qiu, Lu; Che, Yan-Li; Wang, Zong-Qing


    Abstract The cockroach genus Eucorydia from China is revised. Five new species are described and illustrated: Eucorydia linglong sp. n., Eucorydia pilosa sp. n., Eucorydia splendida sp. n., Eucorydia guilinensis sp. n., and Eucorydia tangi sp. n.. Corydia purpuralis Kirby, 1903 and Eucorydia paucipilosa Woo, Guo & Feng, 1986 are confirmed to be junior synonyms of Eucorydia dasytoides (Walker, 1868). Eucorydia hilaris (Kirby, 1903) is newly recorded from China. This genus and currently known species from around the world are discussed. The status of Eucorydia maxwelli (Hanitsch, 1915) is revived. Corydia plagiata Walker, 1868 is confirmed to be a junior synonym of Eucorydia ornata (Saussure, 1864). A checklist, key, and photographs of members of this genus are provided. PMID:29187785

  11. Nanobiomaterials development and applications

    CERN Document Server

    Papaefthymiou-Davis, Georgia C


    Nanomaterials in Nanobiotechnologies: Preparation, Characterization, and ApplicationsBio-Inspired Magnetic NanoparticlesGeorgia C. Papaefthymiou and Eamonn DevlinNanoparticles for BioimagingHye Sun Park and Yong Taik LimBiomedical Applications of Dendrimer Porphyrin or PhthalocyanineWoo-Dong Jang and Won-Gun KohPolymeric Nanoparticles in Cancer TherapyHeebeom Koo, Ji Young Yhee, Ick Chan Kwon, Kwangmeyung Kim, and Ramesh SubbiahCarbon Nanotube BioconjugatesMonica Samal, Dong Kee Yi, and Shashadhar SamalBiocatalytic NanosystemsJaehong Lim and Su Seong LeeMagnetically Induced Hyperthermia for Biomedical ApplicationsMichael Fardis, Ioannis Rabias, Georgios Diamantopoulos, Eleni Karakosta, Danai Tsitrouli, Vassilios Tzitzios, and Georgios PapavassiliouSoft Block Nanobuilding: New Preparation Routes of Soft Nanomaterials Using BiomoleculesEngineered Biomolecules as NanomaterialsYun Jung Lee and Ki Tae NamNanomaterials and Bio-MEMS: Nano- and Microscale Hybridization of Materials and ApplicationsMicrofluidic-Based ...

  12. For love or money? The saga of Korean women who provided eggs for embryonic stem cell research. (United States)

    Baylis, Françoise


    In 2004 and 2005, Woo-Suk Hwang achieved international stardom with publications in Science reporting on successful research involving the creation of stem cells from cloned human embryos. The wonder and success all began to unravel, however, when serious ethical concerns were raised about the source of the eggs for this research. When the egg scandal had completely unfolded, it turned out that many of the women who provided eggs for stem cell research had not provided valid consents and that nearly 75% of the women egg providers had received cash or in-kind payments. Among those who did not receive direct benefits, some cited patriotism as their reason for participating in embryonic stem cell research, hence the question "for love or money?"--namely, patriotism versus payment. This paper summarizes the Hwang debacle with particular attention to the egg scandal and ends with some preliminary thoughts on patriotism as a motive for research participation.

  13. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1985. Part 10 (Hi Plains Supply - International Cnslt Eng Inc). (United States)


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  14. All Prime Contract Awards by State or Country, Place, and Contractor, FY 85. Part 15 (Altus, Oklahoma - Zelienople, Pennsylvania). (United States)


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  15. Progress in the exploitation of new dwarfing genes in Chinese rice breeding

    International Nuclear Information System (INIS)

    Zhu, L.H.; Xie, Z.Q.


    Full text: Use of dwarfing genes in rice breeding in China began in the late 1950's. Since then, the major source of dwarfism has been 'Ai-zi-Zhan' with a gene allelic to sd-1 from 'Dee-Geo-Woo-Gen'. Since the 1970's, Chinese rice breeders paid attention to exploring new dwarfing gene sources and these efforts resulted in at least 7 sources non-allelic to sd-1. The late indica variety 'Gui-Yang-Ai No. 1' possessing gene dg(t) or sdg[t) proved to be most promising. The new sources include mutants induced by irradiation in 'Nanjing 11' and 'Nanjing 15'. The new genes are integrated in breeding to further improve plant type and adaptability. (author)

  16. All Prime Contract Awards by State or Country, Place, and Contractor. Part 21 (Stafford Virginia-Yellowstone Park) (United States)


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  17. Trypanosoma vivax infection dynamics in a cattle herd maintained in a transition area between Pantanal lowlands and highlands of Mato Grosso do Sul, Brazil Dinâmica de infecção de Trypanosoma vivax em rebanho bovino mantido numa área de transição entre o Pantanal e o planalto de Mato Grosso do Sul

    Directory of Open Access Journals (Sweden)

    Charles F. Martins


    Full Text Available Trypanosoma vivax outbreaks in beef cattle in the Pantanal region of Mato Grosso do Sul state, Brazil, causes relevant economical impact due to weight loss, abortion and mortality. Cattle moved from the Pantanal to adjacent areas of this ecosystem for breeding and fattening is a common feature. Therefore an epidemiological study on breeding cows in the transition area between Pantanal lowland and adjacent highlands of Mato Grosso do Sul was performed to determine the T. vivax infection dynamics and outbreak risk. Three experimental groups were formed: Group 1 consisted of cows parasitologically negative by the Woo test and in the enzyme-linked immunosorbent assay for T. vivax antibody detection (Tv-ELISA-Ab; Group 2 parasitologically negative and positive in the Tv-ELISA-Ab; and in Group 3 cows were parasitologically positive and with positive reactions in the Tv-ELISA-Ab. During 24 months, the cows' dislodgment between the above established groups was monitored by Woo test and Tv-ELISA-Ab exams. The tabanid population was also monitored and the highest number occurred during the rainy season. Although parasitemias were detected only in the first four samplings of the experimental period, the cows could be considered as trypanotolerant, because no clinical signs were observed. Despite the higher T. vivax incidence during the dry season, no disease symptoms were seen. Even though T. vivax epidemiological situation in the herd was characterized as endemic with seasonal variation, the probability of outbreaks was null within the conditions of the study.Surtos de Trypanosoma vivax em bovinos de corte do Pantanal foram responsáveis por relevante impacto econômico, devido a perda de peso, abortos e mortalidade. Um manejo comum é o deslocamento de bovinos do Pantanal baixo para áreas adjacentes desse ecosistema para reprodução e engorda. Por essa razão, foi efetuado um estudo epidemiológico em rebanho de vacas movidas para uma área de transi

  18. The Atacama Cosmology Telescope: The Receiver and Instrumentation (United States)

    Swetz, D. S.; Ade, P. A. R.; Amiri, M.; Appel, J. W.; Burger, B.; Devlin, M. J.; Dicker, S. R.; Doriese, W. B.; Essinger-Hileman, T.; Fisher, R. P.; hide


    The Atacama Cosmology Telescope was designed to measure small-scale anisotropies in the Cosmic Microwave Background and detect galaxy clusters through the Sunyaev-Zel'dovich effect. The instrument is located on Cerro Taco in the Atacama Desert, at an altitude of 5190 meters. A off-axis Gregorian telescope feeds a new type of cryogenic receiver, the Millimeter Bolometer Array Camera. The receiver features three WOO-element arrays of transition-edge sensor bolometers for observations at 148 GHz, 218 GHz, and 277 GHz. Each detector array is fed by free space mm-wave optics. Each frequency band has a field of view of approximately 22' x 26'. The telescope was commissioned in 2007 and has completed its third year of operations. We discuss the major components of the telescope, camera, and related systems, and summarize the instrument performance.

  19. Engineering design and economic evaluation of a family-sized biogas project in Nigeria

    International Nuclear Information System (INIS)

    Adeoti, O.; Ilori, M.O.; Oyebisi, T.O.; Adekoya, L.O.


    To woo householders into harnessing the cooking energy potential of biogas in order to solve the perennial cooking energy problems at household level in Nigeria, this paper carried out the engineering design requirement, and used the discounted cash flow micro-economic assessments to evaluate the 6.0 m 3 family-sized biogas project in Nigeria. The project has an initial investment cost of 41,088 Naira, annual expenditure of 5909 Naira and an annual benefit of 13,347 Naira. The NPV, IRR, B/C and payback period of financial analysis are 0.050 million Naira, 17.52%, 2.26 and 6.6 years respectively. This shows that the 6.0 m 3 family-sized biogas project using cattle dung as substrate in Nigeria has a good economic potential. (author)

  20. Development of a high-pressure compaction system for non-combustible solid waste

    International Nuclear Information System (INIS)

    Yogo, S.; Hata, T.; Torita, K.; Yamamoto, K.; Karita, Y.


    In recent years, nuclear power plants in Japan have been in search of a means to reduce the volume of non-combustible solid wastes and therefore the application of a high-pressure compaction system has been in demand. Most non-combustible solid wastes have been packed in 200-litre drums for storage and the situation requires a high-pressure compaction system designed exclusively for 200-litre drums. The authors have developed a high-pressure compaction system which compresses 200-litre drums filled with non-combustible solid wastes and packs them into new woo-litre drums efficiently. This paper reports the outline of this high-pressure compaction system and the results of the full-scale verification tests

  1. An Elastic-Plastic Finite Element Analysis of Notched Aluminum Panels. (United States)


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    Directory of Open Access Journals (Sweden)



    Full Text Available Marriage is the second most significant moment from a man’s life, an event that gives the opportunity of a rich display of folkloric manifestations. The ceremonial complex of the wedding mark, in a festive manner, the passing to another social statute. In Oltenia, it generally has a unitary structure, with small individualising elements, from one village to the other. The nuptial ceremony also presents in its development the three categories of rites, specific to the passing rites, such are: preliminary, liminary, post-liminary. Therefore, the nuptial scenario includes the existence of new rules and a logical succession in the development of the sequences. In the present material, we are going to stop on the customs from the stage that precedes the nuptial ceremony (wooing, discussing the dowry of the girl, the engagement, trying to point towards few dominant element of the phenomenon.

  3. Spectral broadening of planetary radar signals by the solar wind

    International Nuclear Information System (INIS)

    Harmon, J.K.; Coles, W.A.


    The microturbulence spectrum of the solar wind is estimated using the spectral broadening of planetary radar signals. Observations were made with the two radars (12.6 cm and 70 cm) at Arecibo Observatory during the 1979 and 1981 superior conjunctions of Venus. These observations, which span the solar distance range of 5.4 to 25.5 R/sub sun/, are the first of their type to be reported. The data are consistent with earlier observations where comparisons can be made. The flattening of the high-frequency portion of the spectrum near the Sun reported by Woo and Armstrong is confirmed. In one case clear evidence for an inner scale in the vicinity of 2 km is found. Two transients, 1979 August 15 and 1981 April 24-25, with rather different characteristics were observed

  4. Official Guard and Reserve Manpower Strengths and Statistics: FY 1989 Summary (United States)


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  5. High risk for revision after shoulder arthroplasty for failed osteosynthesis of proximal humeral fractures

    DEFF Research Database (Denmark)

    Kristensen, Marc Randall; Rasmussen, Jeppe Vejlgaard; Elmengaard, Brian


    Background and purpose - It is unclear whether previous osteosynthesis is a risk factor for inferior outcome following shoulder arthroplasty for a proximal humeral fracture. We used data from the Danish Shoulder Arthroplasty Registry (DSR) to examine this question. Patients and methods - All 285...... patients treated with a shoulder arthroplasty after failed osteosynthesis of a proximal humeral fracture reported to DSR from 2006 to 2013 were included. Each case was matched with 2 controls (570) treated with a primary shoulder arthroplasty for an acute proximal humeral fracture. Patient reported outcome...... for a shoulder arthroplasty after failed osteosynthesis was 2 with a primary arthroplasty for fracture as reference. In a separate analysis of patients treated by locking plate the mean WOOS was 46 (24), with a relative risk of revision at 1.5 with a primary arthroplasty as reference. Interpretation - Compared...

  6. Shock wave science and technology reference library

    CERN Document Server


    This book is the second of several volumes on solids in the Shock Wave Science and Technology Reference Library. These volumes are primarily concerned with high-pressure shock waves in solid media, including detonation and high-velocity impact and penetration events. Of the four extensive chapters in this volume, the first two describe the reactive behavior of condensed phase explosives, - Condensed-Phase Explosives: Shock Initiation and Detonation Phenomena (SA Sheffield and R Engelke) - First Principles Molecular Simulations of Energetic Materials at High-Pressures (F Zhang, S Alavi, and TK Woo), and the remaining two discuss the inert, mechanical response of solid materials. - Combined Compression and Shear Plane Waves (ZP Tang and JB Aidun), and - Dynamic Fragmentation of Solids (D Grady). All chapters are each self-contained, and can be read independently of each other. They offer a timely reference, for beginners as well as professional scientists and engineers, on the foundations of detonation phenomen...

  7. Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems

    Directory of Open Access Journals (Sweden)

    Jalani G


    Full Text Available Ghulam Jalani,* Chan Woo Jung,* Jae Sang Lee, Dong Woo Lim Department of Bionano Engineering, College of Engineering Sciences, Hanyang University, Education Research Industry Cluster at Ansan Campus, Ansan, South Korea*These authors contributed equally to this workAbstract: Stimuli-responsive, polymer-based nanostructures with anisotropic compartments are of great interest as advanced materials because they are capable of switching their shape via environmentally-triggered conformational changes, while maintaining discrete compartments. In this study, a new class of stimuli-responsive, anisotropic nanofiber scaffolds with physically and chemically distinct compartments was prepared via electrohydrodynamic cojetting with side-by-side needle geometry. These nanofibers have a thermally responsive, physically-crosslinked compartment, and a chemically-crosslinked compartment at the nanoscale. The thermally responsive compartment is composed of physically crosslinkable poly(N-isopropylacrylamide poly(NIPAM copolymers, and poly(NIPAM-co-stearyl acrylate poly(NIPAM-co-SA, while the thermally-unresponsive compartment is composed of polyethylene glycol dimethacrylates. The two distinct compartments were physically crosslinked by the hydrophobic interaction of the stearyl chains of poly(NIPAM-co-SA or chemically stabilized via ultraviolet irradiation, and were swollen in physiologically relevant buffers due to their hydrophilic polymer networks. Bicompartmental nanofibers with the physically-crosslinked network of the poly(NIPAM-co-SA compartment showed a thermally-triggered shape change due to thermally-induced aggregation of poly(NIPAM-co-SA. Furthermore, when bovine serum albumin and dexamethasone phosphate were separately loaded into each compartment, the bicompartmental nanofibers with anisotropic actuation exhibited decoupled, controlled release profiles of both drugs in response to a temperature. A new class of multicompartmental nanofibers could be

  8. The Subtitling of Indigenous Values in the Film Seediq Bale

    Directory of Open Access Journals (Sweden)

    Tzu-yi Elaine Lee


    Full Text Available The movie Seediq Bale, directed by Wei Te-Sheng and produced by John Woo, is a Taiwanese historical drama epic film based on the Wushe Incident in 1930. The story depicts the Wushe Incident, which happened in central Taiwan while it was under Japanese rule. Mona Rudao, a then chief of Seediq indigenous village Mahebu, led warriors against Japanese authorities due to the long-term colonial oppression. In response, the Japanese mounted a relentless counter-attack, killing over three hundred Seediq people. Often compared by the media in Taiwan to the films Braveheart and The Last of the Mohicans, the film, released in 2011, is so far the most expensive production in Taiwan cinema history. Different language registers are present in the movie, including Mandarin, Japanese, and the Seediq language; this can be a great challenge for the translator when translating the subtitles into English. Nonetheless, it is believed that ideologies can be manifested in language use. So, the study attempts to disclose the translator¡¦s hidden indigenous ideologies in the English subtitles s/he provided. Moreover, as subtitling translation involves a multiplicity of verbal and non-verbal semiotic modes, those visual and audio elements could also contribute to the final product of subtitle translations. Hence, the study, in addition to the translator¡¦s indigenous ideologies and handling of ethnic issues in translation, also looks at how the translator worked with semiotic modes in designing the subtitles for the target context.

  9. Boomers versus Millennials: Online Media Influence on Media Performance and Candidate Evaluations

    Directory of Open Access Journals (Sweden)

    Terri Towner


    Full Text Available Facebook posts, YouTube videos, tweets and wooing political bloggers have become standard practice in marketing political campaigns. Research has demonstrated the effect of new media on a host of politically-related behavior, including political participation, knowledge acquisition, group formation and self-efficacy. Yet, issues related to media trust, media performance and candidate evaluations have not been fully explored. In addition, much of the political marketing research looks exclusively at the Millennial age cohort, ignoring other age groups, particularly Baby Boomers. This case study addresses whether attention to traditional (i.e., television, hard-copy newspapers and radio and online media sources (i.e., political candidate websites, television network websites, online newspapers, Facebook, Twitter, YouTube, Tumblr and political blogs about the 2012 U.S. presidential campaign influences Millennials and Baby Boomers’ media trust and performance ratings, as well as candidate evaluations. Panel surveys were completed by both age cohorts, Millennials (n = 431 and Baby Boomers (n = 360, during the last two weeks of the presidential election. Findings indicate that traditional sources, specifically television, rather than online sources are significantly linked to media trust and performance ratings among both Boomers and Millennials. Attention to traditional media for campaign information predicts Boomers’ candidate evaluations, whereas Millennials’ candidate evaluations are influenced by online sources, such as Facebook and candidate websites.

  10. Development of a chitosan based double layer-coated tablet as a platform for colon-specific drug delivery

    Directory of Open Access Journals (Sweden)

    Kim MS


    Full Text Available Min Soo Kim,1,* Dong Woo Yeom,1,* Sung Rae Kim,1 Ho Yub Yoon,1 Chang Hyun Kim,1 Ho Yong Son,1 Jin Han Kim,1 Sangkil Lee,2 Young Wook Choi1 1College of Pharmacy, Chung-Ang University, Seoul, 2College of Pharmacy, Keimyung University, Daegu, South Korea *These authors contributed equally to this work Abstract: A double layer-coated colon-specific drug delivery system (DL-CDDS was developed, which consisted of chitosan (CTN based polymeric subcoating of the core tablet containing citric acid for microclimate acidification, followed by an enteric coating. The polymeric composition ratio of Eudragit E100 and ethyl cellulose and amount of subcoating were optimized using a two-level factorial design method. Drug-release characteristics in terms of dissolution efficiency and controlled-release duration were evaluated in various dissolution media, such as simulated colonic fluid in the presence or absence of CTNase. Microflora activation and a stepwise mechanism for drug release were postulated. Consequently, the optimized DL-CDDS showed drug release in a controlled manner by inhibiting drug release in the stomach and intestine, but releasing the drug gradually in the colon (approximately 40% at 10 hours and 92% at 24 hours in CTNase-supplemented simulated colonic fluid, indicating its feasibility as a novel platform for CDD. Keywords: chitosan, colon-specific delivery, acidification, microflora, factorial design, controlled release

  11. The beneficial effects of honeybee-venom serum on facial wrinkles in humans

    Directory of Open Access Journals (Sweden)

    Han SM


    Full Text Available Sang Mi Han,1 In Phyo Hong,1 Soon Ok Woo,1 Sung Nam Chun,2 Kwan Kyu Park,3 Young Mee Nicholls,4 Sok Cheon Pak5 1Department of Agricultural Biology, National Academy of Agricultural Science, Wanju, 2Dong Sung Pharmaceuticals Co Ltd, Seoul, 3Department of Pathology, School of Medicine, Catholic University of Daegu, Daegu, South Korea; 4Manuka Doctor Ltd, Auckland, New Zealand; 5School of Biomedical Sciences, Charles Sturt University, Bathurst, NSW, Australia Abstract: Facial wrinkles are an undesirable outcome caused by extrinsic photodamage and intrinsic aging processes. Currently, no effective strategies are known to prevent facial wrinkles. We assessed the beneficial effects of bee-venom serum on the clinical signs of aging skin. Our results show that bee-venom serum treatment clinically improved facial wrinkles by decreasing total wrinkle area, total wrinkle count, and average wrinkle depth. Therefore, bee-venom serum may be effective for the improvement of skin wrinkles. Keywords: bee venom, wrinkle, area, count, depth

  12. Genetic analysis of plant height in induced mutants of aromatic rice

    International Nuclear Information System (INIS)

    Kole, P.C.


    Inheritance of plant height in five gamma-ray induced mutants of aromatic rice cultivar Gobindabhog was studied through 6 x 6 diallel cross and segregation analyses. Diallel analysis revealed presence of additive and non-additive gene action with the preponderance of the latter. Proportion of dominant and recessive alleles was distributed unequally among the parents. The direction of dominance was towards tallness. The number of groups of genes was found to be three. The segregation analysis indicated the role of a single major recessive gene for height reduction in three mutants and, in another mutant, a single major recessive gene with negative modifiers. The other semi-dwarf mutant had two major recessive genes with almost equal effect in height reduction. The mutant allele(s) of the latter two mutants were non-allelic to sd sub(1) gene, which could be used as an alternative source of Dee Gee Woo Gen to widen the genetic diversity in semi-dwarfism [it

  13. The Effect of Hominis Placenta Herbal Acupuncture on Bell's palsy

    Directory of Open Access Journals (Sweden)

    Yun Jeong-hun


    Full Text Available This report was done to observe the effect of Hominis placenta herbal acupuncture on Bell's palsy. The study group comprised 16 patients who arrived at Woo-suk university oriental hospital from January, 1999 till January, 2000 for Bell's palsy. All patients were divided into two group. One was herbal acupunture group, and the other was control group. Acupunture group was done herbal acupuncture therapy on the facial acupuncture points. Followings are achievement and a term of each group. In herbal acupuncture group, 100% motor recovery was 7 case, 75% was 1 case, and 25% motor recovery term was 7.38±5.21 days, 50% was 11.00±6.16 days, 75% was 15.13±9.55 days, 100% was 23.14±7.97 days. In control group, 100% motor recovery was 4 case, 75% was 2 case, 25% below was 2 case and 25% motor recovery term was 11.17±4.96days, 50% was 18.17±6.82 days, 75% was 29.50±6.95 days, 100% was 44.00±11.49 days. The above results indicate that Hominis placenta herbal acupuncture is a useful effect on Bell's palsy. thus, continuous herbal acupunture study will be needed for more clinical application on Bell' palsy.

  14. Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Nanticoke Maryland - Garden City Michigan) (United States)


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  15. Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Norwich Vermont - Melrose Virginia) (United States)


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  16. Use of PROMIS for Patients Undergoing Primary Total Shoulder Arthroplasty. (United States)

    Dowdle, S Blake; Glass, Natalie; Anthony, Chris A; Hettrich, Carolyn M


    The Patient-Reported Outcomes Measurement Information System (PROMIS) consists of question banks for health domains through computer adaptive testing (CAT). For patients with glenohumeral arthritis, (1) there would be high correlation between traditional patient-reported outcome (PRO) measures and the PROMIS upper extremity item bank (PROMIS UE) and PROMIS physical function CAT (PROMIS PF CAT), and (2) PROMIS PF CAT would not demonstrate ceiling effects. Cohort study (diagnosis); Level of evidence, 3. Sixty-one patients with glenohumeral osteoarthritis were included. Each patient completed the American Shoulder and Elbow Surgeons (ASES) assessment form, Marx Shoulder Activity Scale, Short Form-36 physical function scale (SF-36 PF), EuroQol 5 Dimensions (EQ-5D) questionnaire, Western Ontario Osteoarthritis Shoulder (WOOS) index, PROMIS PF CAT, and the PROMIS UE. Correlation was defined as high (>0.7), moderate (0.4-0.6), or weak (0.2-0.3). Significant floor and ceiling effects were present if more than 15% of individuals scored the lowest or highest possible total score on any PRO. The PROMIS PF demonstrated excellent correlation with the SF-36 PF ( r = 0.81, P ceiling or floor effects observed. The mean number of items administered by the PROMIS PRO was 4. These data suggest that for a patient population with operative shoulder osteoarthritis, PROMIS UE and PROMIS PF CAT may be valid alternative PROs. Additionally, PROMIS PF CAT offers a decreased question burden with no ceiling effects.

  17. A Single Recessive Mutated Gene (Sd237-1) Controlling Semi-Dwarf Plant Stature of Rice

    International Nuclear Information System (INIS)



    Dwarfism is a valuable trait in crop breeding, because it increases lodging resistance and decreases damages due to wind and rain. During the course of this study, a semi-dwarf mutant was successfully induced through 200 Gy gamma ray irradiated KI 237 seeds. KI 237 is a pure line with high yield potency, developed through an Indica-Japonica cross of IR36 / Koshihikari. The selected semi-dwarf plant reached 60 - 62 % of plant height of original plant KI 237 at the mature stage. The length of inter nodes, panicle, and seed were also compared between these two plants. The retardation of the 1 st (uppermost) inter nodes was 24 %, moreover, the retardation of panicle and seed length were only 10 % and 2 %, respectively. The elongation pattern of the inter nodes in this mutant was almost the same as sd1 (Dee-geo-woo-gen), the original parent of the first release modern rice variety, but their performances were different. Based on the segregation analysis in M 2 and M 3 generation it was concluded that this mutant was controlled by a single recessive mutated gene. This gene was designated as sd 237-1 . This mutant should be useful as a genetic resource for the improvement of KI 237 line through back-cross breeding as well as be developed further in breeding program directly to be a new high yielding mutant variety. (author)

  18. Omega-3 fatty acid supplementation can improve both symptoms and signs of dry eye disease

    Directory of Open Access Journals (Sweden)

    Kwon J


    Full Text Available Jae-Woo Kwon,1 Sang Beom Han2 1Department of Internal Medicine, 2Department of Ophthalmology, Kangwon National University Hospital, Kangwon National University Graduate School of Medicine, Chuncheon, South Korea We read with great interest the article by Gatell-Tortajada1 entitled “Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study”. The prospective large-scale study was undoubtedly well designed and conducted, and the authors should be congratulated for successfully demonstrating that oral omega-3 fatty acid supplementation can be an effective treatment for dry eye symptoms.1The authors showed that supplementation of omega-3 fatty acids improved dry eye signs, such as corneal erosion, tear film breakup time, and conjunctival hyperemia, suggesting that they can reduce ocular surface inflammation and also alleviate dry eye symptoms.1 Rashid et al2 also demonstrated that topical application of omega-3 fatty acids led to a decrease in dry eye signs and inflammatory changes at both cellular and molecular levels.  View original paper by Gatell-Tortajada

  19. Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (San Juan California - Yale New Haven Conn) (United States)


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  20. Enhanced therapeutic efficacy of budesonide in experimental colitis with enzyme/pH dual-sensitive polymeric nanoparticles

    Directory of Open Access Journals (Sweden)

    Naeem M


    Full Text Available Muhammad Naeem, Jiafu Cao, Moonjeong Choi, Woo Seong Kim, Hyung Ryong Moon, Bok Luel Lee, Min-Soo Kim, Yunjin Jung, Jin-Wook Yoo College of Pharmacy, Pusan National University, Busan, South Korea Abstract: Current colon-targeted drug-delivery approaches for colitis therapy often utilize single pH-triggered systems, which are less reliable due to the variation of gut pH in individuals and in disease conditions. Herein, we prepared budesonide-loaded dual-sensitive nanoparticles using enzyme-sensitive azo-polyurethane and pH-sensitive methacrylate copolymer for the treatment of colitis. The therapeutic potential of the enzyme/pH dual-sensitive nanoparticles was evaluated using a rat colitis model and compared to single pH-triggered nanoparticles. Clinical activity scores, colon/body weight ratios, myeloperoxidase activity, and proinflammatory cytokine levels were markedly decreased by dual-sensitive nanoparticles compared to single pH-triggered nanoparticles and budesonide solution. Moreover, dual-sensitive nanoparticles accumulated selectively in inflamed segments of the colon. In addition, dual-sensitive nanoparticle plasma concentrations were lower than single pH-triggered nanoparticles, and no noticeable in vitro or in vivo toxicity was observed. Our results demonstrate that enzyme/pH dual-sensitive nanoparticles are an effective and safe colon-targeted delivery system for colitis therapy. Keywords: azo-polyurethane, methacrylate copolymer, budesonide, colon-targeted nanoparticles, colitis

  1. Two Wooers and their Sonnets: On Poetic Forms in Romeo and Juliet

    Directory of Open Access Journals (Sweden)

    Elena V. Haltrin-Khalturina


    Full Text Available The article looks at the semiotics of the sonnet form used by Shakespeare in his tragedy Romeo and Juliet. Particular attention is paid to two sonnets, of Paris and of Romeo, in which different manners of courting are played out. The poetic “gift” from Romeo to Juliet, their shared sonnets, one complete and one interrupted (Act 1, Sc. 5, ls. 92–109, is a notorious and much discussed piece of Shakespeare’s dramatic poetry. However, the other wooing sonnet representing desires of Paris and mouthed by Lady Capulet (Act 1, Sc. 3, ls. 80–95, seems to lack that kind of attention. Our essay juxtaposes the two sonnets in question, which are built around extended metaphors (conceits. Romeo’s sonneteering is endowed with dramatic power that quickens the debate and inspires accord between the title’s heroes. The semantic charge of this shared sonnet resonates in the heroes’ scenic gestures, prompting the play’s outcome. By contrast, the rather inert sonnet of Paris is like a dead letter of bookish instruction, which neither inspires amorous response, nor moves Juliet. The article also places Romeo’s and Paris’s pieces against Shakespeare’s sonnets 128 and 126 of the 1609 edition.

  2. Predictors of premature discontinuation of outpatient treatment after discharge of patients with posttraumatic stress disorder

    Directory of Open Access Journals (Sweden)

    Wang HR


    Full Text Available Hee Ryung Wang, Young Sup Woo, Tae-Youn Jun, Won-Myong Bahk Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea Objective: This study aimed to examine the sociodemographic and disease-related variables associated with the premature discontinuation of psychiatric outpatient treatment after discharge among patients with noncombat-related posttraumatic stress disorder. Methods: We retrospectively reviewed the medical records of patients who were discharged with a diagnosis of posttraumatic stress disorder. Results: Fifty-five percent of subjects (57/104 prematurely discontinued outpatient treatment within 6 months of discharge. Comparing sociodemographic variables between the 6-month non-follow-up group and 6-month follow-up group, there were no variables that differed between the two groups. However, comparing disease-related variables, the 6-month follow-up group showed a longer hospitalization duration and higher Global Assessment of Function score at discharge. The logistic regression analysis showed that a shorter duration of hospitalization predicted premature discontinuation of outpatient treatment within 6 months of discharge. Conclusion: The duration of psychiatric hospitalization for posttraumatic stress disorder appeared to influence the premature discontinuation of outpatient treatment after discharge. Keywords: posttraumatic stress disorder, discontinuation, compliance, predictor

  3. An expanding sexual economy along National Route 3 in Luang Namtha Province, Lao PDR. (United States)

    Doussantousse, Serge; Sakounnavong, Bounchanh; Patterson, Ian


    With some of the lowest development indicators in Southeast Asia, remote upland areas of the Lao People's Democratic Republic are among the poorest in the region. The advent of improved transport and communication links, along with opportunities for wage employment, have accelerated the growth of a cash economy in traditionally isolated farming communities of Luang Namtha Province. Interviews and focus group discussions with young people, women in the sexual service business and health workers indicate that the lure of the new economy is wooing villagers away from their agrarian roots. Motorbikes and mobile phones have expanded the sexual territory of indigenous youth at a time when international commerce and a cash economy along improved highways are bringing new people into the region. Among the concerns for their health and safety are at-risk behaviours involving alcohol and sexual practices, especially HIV and sexually transmitted infections. Of particular concern is the sexual trade in the province with a predominance of young, poorly educated Khmou women providing sexual services in a growing number of entertainment places.

  4. Multiple cues on the physiochemical, mesenchymal, and intracellular trafficking interactions with nanocarriers to maximize tumor target efficiency

    Directory of Open Access Journals (Sweden)

    Kim SW


    Full Text Available Sang-Woo Kim, Dongwoo Khang Nanomedicine Laboratory, Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, South Korea Abstract: Over the past 60 years, numerous medical strategies have been employed to overcome neoplasms. In fact, with the exception of lung, bronchial, and pancreatic cancers, the 5-year survival rate of most cancers currently exceeds 70%. However, the quality of life of patients during chemotherapy remains unsatisfactory despite the increase in survival rate. The side effects of current chemotherapies stem from poor target efficiency at tumor sites due to the uncontrolled biodistribution of anticancer agents (ie, conventional or current approved nanodrugs. This review discusses the effective physiochemical factors for determining biodistribution of nanocarriers and, ultimately, increasing tumor-targeting probability by avoiding the reticuloendothelial system. Second, stem cell-conjugated nanotherapeutics was addressed to maximize the tumor searching ability and to inhibit tumor growth. Lastly, physicochemical material properties of anticancer nanodrugs were discussed for targeting cellular organelles with modulation of drug-release time. A better understanding of suggested topics will increase the tumor-targeting ability of anticancer drugs and, ultimately, promote the quality of life of cancer patients during chemotherapy. Keywords: cancer, anticancer nanodrugs, mesenchymal stem cell, intracellular trafficking

  5. Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites

    KAUST Repository

    Woo, Yong


    The eukaryotic phylum Apicomplexa encompasses thousands of obligate intracellular parasites of humans and animals with immense socio-economic and health impacts. We sequenced nuclear genomes of Chromera velia and Vitrella brassicaformis, free-living non-parasitic photosynthetic algae closely related to apicomplexans. Proteins from key metabolic pathways and from the endomembrane trafficking systems associated with a free-living lifestyle have been progressively and non-randomly lost during adaptation to parasitism. The free-living ancestor contained a broad repertoire of genes many of which were repurposed for parasitic processes, such as extracellular proteins, components of a motility apparatus, and DNA- and RNA-binding protein families. Based on transcriptome analyses across 36 environmental conditions, Chromera orthologs of apicomplexan invasion-related motility genes were co-regulated with genes encoding the flagellar apparatus, supporting the functional contribution of flagella to the evolution of invasion machinery. This study provides insights into how obligate parasites with diverse life strategies arose from a once free-living phototrophic marine alga. © Woo et al.


    Directory of Open Access Journals (Sweden)

    K. V. Dobrego


    Full Text Available Modern Cooling Towers (CT may utilize different aerodynamic elements (deflectors, windbreak walls etc. aimed to improvement of its heat performance especially at the windy conditions. In this paper the effect of flow rotation in overshower zone of CT and windbreak walls on a capacity of tower evaporating unit in the windy condition is studied numerically. Geometry of the model corresponds to real Woo-Jin Power station, China. Analogy of heat and mass transfer was used that allowed to consider aerodynamic of one-dimension flow and carried out detailed 3D calculations applying modern PC. Heat transfer coefficient of irrigator and its hydrodynamic resistance were established according to experimental data on total air rate in cooling tower. Numerical model is tested and verified with experimental data.Nonlinear dependence of CT thermal performance on wind velocity is demonstrated with the minimum (critical wind velocity at ucr ~ 8 m/s for simulated system. Application of windbreak walls does not change the value of the critical wind velocity, but may improves performance of cooling unit at moderate and strong wind conditions. Simultaneous usage of windbreak walls and overshower deflectors may increase efficiency up to 20–30 % for the deflectors angle a = 60o. Simulation let one analyze aerodynamic patterns, induced inside cooling tower and homogeneity of velocities’ field in irrigator’s area.Presented results may be helpful for the CT aerodynamic design optimization, particularly, for perspective hybrid type CTs.

  7. Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (Claude Ralph - Day Francis O Co. Inc.) (United States)


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  8. Anti-nuclear activities and critics concerning nuclear power plant sites

    International Nuclear Information System (INIS)

    Rhee, We-Beg


    Korea has dynamic nuclear power expansion programs, operating 16 nuclear units producing 13710 MW in total located on 4 different sites. Last year, nuclear power supplied over 40 % of national total electricity demands. In 1998, Korean government initiated re-designation work investigating circumstance changes to rule out the unnecessary sites in consideration of a long-term power supply. Korean government has determined to expand the Ulchin site and to designate one point of Woolju county as a new candidate site, and ruled out the rest candidate sites at the end of 1998. About such a governmental measure, the two areas show different reactions. Ulchin where nuclear power plant has been operated safely for about 10 years was likely to accept the governmental determination in spite of some opposition and called for several financial supports for local development. WooIju county, however, showed a strong opposition among local environmental groups and autonomous politicians, and they presented a variety of anti-nuclear activities including demonstrations mainly at the neighbouring metropolis, Ulsan city

  9. Exploring the link between depression and accelerated cellular aging: telomeres hold the key

    Directory of Open Access Journals (Sweden)

    Yu R


    Full Text Available Ruby Yu, Jean Woo Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, SAR, China Abstract: Accumulating evidence suggests that telomeres may be a marker for biological aging and telomere length may be affected by multifactorial influences, including cumulative exposure to depression. Associations with telomere length have been reported for major depressive disorder, lifetime duration of depression, higher depression severity, and history of depression. The exact underling mechanisms for these associations have yet to be fully elucidated; however, oxidative stress, chronic inflammation, dysregulated hypothalamus-pituitary-adrenal axis, and altered cortisol levels may be important biochemical mediators. These mediators could also be influenced by psychological stress, unhealthy lifestyle behaviors, or other potential factors, such as childhood abuse, post-traumatic stress disorder, and anxiety that are commonly associated with depression. As such, stress reduction and lifestyle interventions that may affect the telomere maintenance system should be considered for individuals with depression.Keywords: depression, telomere length, biomarkers, cellular ageing

  10. Gold nanoparticles promote osteogenic differentiation in human adipose-derived mesenchymal stem cells through the Wnt/β-catenin signaling pathway

    Directory of Open Access Journals (Sweden)

    Choi SY


    Full Text Available Seon Young Choi,1 Min Seok Song,1 Pan Dong Ryu,1 Anh Thu Ngoc Lam,2 Sang-Woo Joo,2 So Yeong Lee1 1Laboratory of Veterinary Pharmacology, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, 2Department of Chemistry, Soongsil University, Seoul, South Korea Abstract: Gold nanoparticles (AuNPs are attractive materials for use in biomedicine due to their physical properties. Increasing evidence suggests that several nanoparticles induce the differentiation of human mesenchymal stem cells into osteoblasts and adipocytes. In this study, we hypothesized that chitosan-conjugated AuNPs promote the osteogenic differentiation of human adipose-derived mesenchymal stem cells. For the evaluation of osteogenic differentiation, alizarin red staining, an alamarBlue® assay, and a quantitative real-time polymerase chain reaction analysis were performed. In order to examine specific signaling pathways, immunofluorescence and a western blotting assay were performed. Our results demonstrate that chitosan-conjugated AuNPs increase the deposition of calcium content and the expression of marker genes related to osteogenic differentiation in human adipose-derived mesenchymal stem cells at nontoxic concentrations. These results indicate that chitosan-conjugated AuNPs promote osteogenesis through the Wnt/β-catenin signaling pathway. Therefore, chitosan-conjugated AuNPs can be used as a reagent for promoting bone formation. Keywords: chitosan-conjugated gold nanoparticle, mineralization, nonphosphorylated beta-catenin

  11. Russian and Chinese Policies of Soft Power in the Central Asia (the Case of Kazakhstan

    Directory of Open Access Journals (Sweden)

    Guangzhen Wang


    Full Text Available The policy of “soft power” has lost some of its power in the Russian foreign policy, but continues to dominate in the minds of researchers. There are a lot of scientific and journalistic articles on this subject. The notion has already become a kind of trend, not only in the field of international relations and in the field of political science. The key criterion for determining the impact of “soft power” is “attraction”, that is how the subject can woo the object in order to have some influence on it. Both Russia and China have a set of instruments of “soft power”, which in varying degrees, allow them to influence the objects, including the countries of Central Asia, especially Kazakhstan. Due to the fact that the KR unofficially became the leader of the region, its example can be most clearly trace the desire of Russia and China to become the most attractive partner for Kazakhstan. The study is based on the Comparative Approach, which allows not only to identify the characteristics of the “soft power” of Russia and China, but to compare their effectiveness. The activities of the two countries is analyzed through the prism of tools used in the region of “soft power”, including investment, educational, scientific and cultural programs.

  12. Hearing Mouth Shapes: Sound Symbolism and the Reverse McGurk Effect

    Directory of Open Access Journals (Sweden)

    Charles Spence


    Full Text Available In their recent article, Sweeny, Guzman-Martinez, Ortega, Grabowecky, and Suzuki (2012 demonstrate that heard speech sounds modulate the perceived shape of briefly presented visual stimuli. Ovals, whose aspect ratio (relating width to height varied on a trial-by-trial basis, were rated as looking wider when a /woo/ sound was presented, and as taller when a /wee/ sound was presented instead. On the one hand, these findings add to a growing body of evidence demonstrating that audiovisual correspondences can have perceptual (as well as decisional effects. On the other hand, they prompt a question concerning their origin. Although the currently popular view is that crossmodal correspondences are based on the internalization of the natural multisensory statistics of the environment (see Spence, 2011, these new results suggest instead that certain correspondences may actually be based on the sensorimotor responses associated with human vocalizations. As such, the findings of Sweeny et al. help to breathe new life into Sapir's (1929 once-popular “embodied” explanation of sound symbolism. Furthermore, they pose a challenge for those psychologists wanting to determine which among a number of plausible accounts best explains the available data on crossmodal correspondences.

  13. 'Blue Whale Challenge': A Game or Crime? (United States)

    Mukhra, Richa; Baryah, Neha; Krishan, Kewal; Kanchan, Tanuj


    A bewildering range of games are emerging every other day with newer elements of fun and entertainment to woo youngsters. Games are meant to reduce stress and enhance the cognitive development of children as well as adults. Teenagers are always curious to indulge in newer games; and e-gaming is one such platform providing an easy access and quicker means of entertainment. The particular game challenge which has taken the world by storm is the dangerous "Blue Whale Challenge" often involving vulnerable teenagers. The Blue Whale Challenge is neither an application nor internet based game but the users get a link through social media chat groups to enter this "deadly" challenge game. This probably is the only game where the participant has to end his/her life to complete the game. The innocent teenagers are being targeted based on their depressed psychology and are coercively isolated from their social milieux on the pretext of keeping the challenges confidential. To add to the woes, no option is offered to quit the challenge even if the contender is unable to complete the challenge. Blue Whale Challenge in its sheer form could be seen as an illegal, unethical and inhumane endeavor in our present society. The present communication discusses the severe effects of the game on teenagers, the ethical concerns involved and the preventive measures necessary to curb it.


    Directory of Open Access Journals (Sweden)

    Ravindra Pal Singh


    Full Text Available Macroalgae are a diverse group of photosynthetic eukaryotic lower organisms and offer indispensable ecosystem services towards sustainable productivity of rocky coastal areas. The earlier studies have mainly focused on elucidation of the roles of the epiphytic bacterial communities in the ecophysiology of the host macroalga. However, mutualistic interactions have become topic of current interest. It is evident from recent studies that a fraction of epiphytic bacterial communities can be categorized as core microbial species, suggesting an obligate association. Epiphytic bacterial communities have also been reported to protect macroalgal surfaces from biofouling microorganisms through production of biologically active metabolites. Because of their intrinsic roles in the host life cycle, the host in turn may provide necessary organic nutrients in order to woo pelagic microbial communities to settle on the host surfaces. However, the precise composition of microbiomes and their functional partnership with hosts are hardly understood. In contrast, the microbial studies associated with human skin and gut and plants have significantly advanced our knowledge on microbiome and their functional interactions with the host. This has led to manipulation of the microbial flora of the human gut and of agricultural plants for improving health and performance. Therefore, it is highly imperative to investigate the functional microbiome that is closely involved in the life cycles of the host macroalgae using high-throughput techniques (metagenomics and metatranscriptomics. The findings from such investigations would help in promoting health and productivity in macroalgal species through regulation of functionally active microbiome.

  15. Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites

    KAUST Repository

    Woo, Yong; Ansari, Hifzur Rahman; Otto, Thomas D.; Linger, Christen M K; Olisko, Martin K.; Michá lek, Jan; Saxena, Alka; Shanmugam, Dhanasekaran; Tayyrov, Annageldi; Veluchamy, Alaguraj; Ali, Shahjahan; Bernal, Axel; Del Campo, Javier; Cihlá ř, Jaromí r; Flegontov, Pavel; Gornik, Sebastian G.; Hajdušková , Eva; Horá k, Aleš; Janouškovec, Jan; Katris, Nicholas J.; Mast, Fred D.; Miranda-Saavedra, Diego; Mourier, Tobias; Naeem, Raeece; Nair, Mridul; Panigrahi, Aswini Kumar; Rawlings, Neil D.; Padron Regalado, Eriko; Ramaprasad, Abhinay; Samad, Nadira; Tomčala, Aleš; Wilkes, Jon; Neafsey, Daniel E.; Doerig, Christian; Bowler, Chris; Keeling, Patrick J.; Roos, David S.; Dacks, Joel B.; Templeton, Thomas J.; Waller, Ross F.; Lukeš, Julius; Oborní k, Miroslav; Pain, Arnab


    The eukaryotic phylum Apicomplexa encompasses thousands of obligate intracellular parasites of humans and animals with immense socio-economic and health impacts. We sequenced nuclear genomes of Chromera velia and Vitrella brassicaformis, free-living non-parasitic photosynthetic algae closely related to apicomplexans. Proteins from key metabolic pathways and from the endomembrane trafficking systems associated with a free-living lifestyle have been progressively and non-randomly lost during adaptation to parasitism. The free-living ancestor contained a broad repertoire of genes many of which were repurposed for parasitic processes, such as extracellular proteins, components of a motility apparatus, and DNA- and RNA-binding protein families. Based on transcriptome analyses across 36 environmental conditions, Chromera orthologs of apicomplexan invasion-related motility genes were co-regulated with genes encoding the flagellar apparatus, supporting the functional contribution of flagella to the evolution of invasion machinery. This study provides insights into how obligate parasites with diverse life strategies arose from a once free-living phototrophic marine alga. © Woo et al.

  16. All Prime Contract Awards by State or Country, Place, and Contractor. Part 23 (Iceland-TRW INC Classified Location) (United States)


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  17. From crops to products for crops: preserving the ecosystem through the use of bio-based molecules

    Directory of Open Access Journals (Sweden)

    Godard Anaïs


    Full Text Available In a context of dwindling oil reserves and environmental pressures, the chemical industry needs to innovate by developing new processes for producing bioproducts from raw plant materials. Unsaturated fatty acids from vegetable oils constitute a highly promising renewable resource that can be used to diversify productions, decreasing reliance on petroleum. A starting material rich in oleic acid has been obtained through the selection of high-oleic sunflower varieties and enzymatic hydrolysis of the oil they produce. The double bonds of this unsaturated raw material have been cleaved in green oxidizing conditions involving a biphasic lipophilic-aqueous system including hydrogen peroxide as an oxidant and a peroxo-tungsten complex Q3 {PO2[WO(O22]4} as a phase-transfer catalyst (PTC and co-oxidant. This PTC efficiently transferred oxygen to the substrate in the lipophilic phase. A mono-acid (pelargonic acid and a di-acid (azelaic acid, with shorter, unusual hydrocarbon chains not present in the natural state, were synthesized and purified through an intensive process. Pelargonic acid was then formulated as an environmentally friendly biocontrol agent for weeds. We extended this green process of oxidative scission to other fatty acids and derivatives, to obtain other short-chain acids with diverse potential applications. This production chain (crops, reaction and purification processes, products, applications is based on a sustainable development strategy.

  18. Candidate genes for COPD: current evidence and research

    Directory of Open Access Journals (Sweden)

    Kim WJ


    Full Text Available Woo Jin Kim,1 Sang Do Lee2 1Department of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon, 2Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea Abstract: COPD is a common complex disease characterized by progressive airflow limitation. Several genome-wide association studies (GWASs have discovered genes that are associated with COPD. Recently, candidate genes for COPD identified by GWASs include CHRNA3/5 (cholinergic nicotine receptor alpha 3/5, IREB2 (iron regulatory binding protein 2, HHIP (hedgehog-interacting protein, FAM13A (family with sequence similarity 13, member A, and AGER (advanced glycosylation end product–specific receptor. Their association with COPD susceptibility has been replicated in multiple populations. Since these candidate genes have not been considered in COPD, their pathological roles are still largely unknown. Herein, we review some evidences that they can be effective drug targets or serve as biomarkers for diagnosis or subtyping. However, more study is required to understand the functional roles of these candidate genes. Future research is needed to characterize the effect of genetic variants, validate gene function in humans and model systems, and elucidate the genes’ transcriptional and posttranscriptional regulatory mechanisms. Keywords: chronic obstructive pulmonary disease, genetics, genome-wide association study

  19. Strategies for changing negative public attitudes toward organ donation in the People's Republic of China

    Directory of Open Access Journals (Sweden)

    Shumin X


    Full Text Available Xie Shumin,1 Stephanie Mu-Lian Woo,2 Zhang Lei3 1Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital of Central South University, Changsha, People's Republic of China; 2Harvard University, Cambridge, Massachusetts, USA; 3Department of Thoracic Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China Abstract: In recent decades, the demand for organ transplantation has risen rapidly worldwide, due to an increased incidence of vital organ failure. However, the scarcity of organs appropriate for transplantation has led to an organ shortage crisis. This article retrospectively reviews strategies to change negative public attitudes toward organ donation in the People's Republic of China. We strongly believe that efforts to publicize knowledge of organ donation, promote family discussions, train medical staff and students, establish incentive systems, and implement regulatory oversight may combat unfavorable Chinese public opinion toward organ donation and transplantation, thus potentially increasing the organ donation rate in the People's Republic of China. Keywords: influencing factors, attitudes, organ transplantation, organ failure

  20. Use of PROMIS for Patients Undergoing Primary Total Shoulder Arthroplasty (United States)

    Dowdle, S. Blake; Glass, Natalie; Anthony, Chris A.; Hettrich, Carolyn M.


    Background: The Patient-Reported Outcomes Measurement Information System (PROMIS) consists of question banks for health domains through computer adaptive testing (CAT). Hypothesis: For patients with glenohumeral arthritis, (1) there would be high correlation between traditional patient-reported outcome (PRO) measures and the PROMIS upper extremity item bank (PROMIS UE) and PROMIS physical function CAT (PROMIS PF CAT), and (2) PROMIS PF CAT would not demonstrate ceiling effects. Study Design: Cohort study (diagnosis); Level of evidence, 3. Methods: Sixty-one patients with glenohumeral osteoarthritis were included. Each patient completed the American Shoulder and Elbow Surgeons (ASES) assessment form, Marx Shoulder Activity Scale, Short Form–36 physical function scale (SF-36 PF), EuroQol 5 Dimensions (EQ-5D) questionnaire, Western Ontario Osteoarthritis Shoulder (WOOS) index, PROMIS PF CAT, and the PROMIS UE. Correlation was defined as high (>0.7), moderate (0.4-0.6), or weak (0.2-0.3). Significant floor and ceiling effects were present if more than 15% of individuals scored the lowest or highest possible total score on any PRO. Results: The PROMIS PF demonstrated excellent correlation with the SF-36 PF (r = 0.81, P ceiling or floor effects observed. The mean number of items administered by the PROMIS PRO was 4. Conclusion: These data suggest that for a patient population with operative shoulder osteoarthritis, PROMIS UE and PROMIS PF CAT may be valid alternative PROs. Additionally, PROMIS PF CAT offers a decreased question burden with no ceiling effects. PMID:28944248

  1. Epidemiology of brucellosis among cattle in Korea from 2001 to 2011 (United States)

    Moon, Oun-Kyong; Lee, Soo-Han; Lee, Won-Chang; Her, Moon; Jeong, Wooseog; Jung, Suk-Chan; Kim, Do-Soon


    In the present study, the outbreak patterns of bovine brucellosis in Korea from 2000 to 2011 were analyzed to understand the epidemiological evolution of this disease in the country. A total of 85,521 brucella reactor animals were identified during 14,215 outbreaks over the 12-year study period. The number of bovine brucellosis cases increased after 2003 and peaked in 2006 before decreasing thereafter. The majority of the bovine brucellosis cases were Korean native cattle, Han Woo. The numbers of human brucellosis cases and cattle outbreaks increased and decreased in the same pattern. The correlation coefficient for human and bovine cases per year was 0.96 (95% confidence interval = 0.86~0.99; p brucellosis appeared to be affected by the intensity of eradication programs that mainly involved a test-and-slaughter policy. Findings from the present study were based on freely available statistics from web pages maintained by government agencies. This unlimited access to information demonstrates the usefulness of government statistics for continually monitoring the health of animal populations. PMID:25234321

  2. Cinema, paesaggio e turismo “andaluzadas”: la Spagna andalusizzata, patrimonio retroproiettato / Cinema, landscape and “andaluzadas” tourism: the Andalusian Spain, a rear-projected heritage

    Directory of Open Access Journals (Sweden)

    Rocío Liáñez Andrades


    Full Text Available La Spagna si è proiettata cinematograficamente al turismo internazionale attraverso la sua immagine più pittoresca e singolare: l’Andalusia. In questo modo, anche nelle produzioni realizzate in altre regioni spagnole (Galizia, Madrid, Castiglia-La Mancia, Catalogna compare lo stereotipo più vincolato alla sua immagine romantica secolare.Questa sineddoche identitaria dell'essere spagnolo è stata agevolata dalle istituzioni turistiche, coscienti della loro capacità di attrazione sul turista straniero, e anche dagli stessi spagnoli, che hanno presentato una visione satirica di questo fenomeno di furto di identità nazionale.Per documentare la nostra ipotesi è stata eseguita l’analisi cinematografica (semiotica e di contenuto di una lista di film proposti, produzioni spagnole e coproduzioni con partecipazione o supporto nazionale. Si tratta di produzioni che non esitano a immergersi negli stereotipi più radicati dell’immaginario andaluso, riconoscendoli e riconoscendosi in questi. Ne emerge in questo modo sia la vocazione etnografica e folkloristica delle produzioni destinate alla proiezione internazionale, sia l’impoverimento della suddetta immagine per l’utente nazionale.Quest’articolo percorre le produzioni sopra citate ed espone l’eventuale collegamento di questi “film pasticcio” con film di recente uscita, come Mission: Impossible 2 (John Woo, 2000, Knight and day (James Mangold, 2010 o Zindagi na milegi dobara (Zoya Akhtar, 2012. Spain presented itself in films in order to promote international tourism through its picturesque and unique image: Andalusia. In this way, including in productions that took place in other regions (Galicia, Madrid, Castile-La Mancha, Catalonia, the basic and most cliché Andalusian appears in its romantic and secular image. This identifying synecdoche of “Spanish Identity” was seen as favored by touristic institutions. Aware of their power of attraction over foreign touristic consumers

  3. Association of blood eosinophils and plasma periostin with FEV1 response after 3-month inhaled corticosteroid and long-acting beta2-agonist treatment in stable COPD patients

    Directory of Open Access Journals (Sweden)

    Park HY


    Full Text Available Hye Yun Park,1 Hyun Lee,1 Won-Jung Koh,1 Seonwoo Kim,2 Ina Jeong,3 Hyeon-Kyoung Koo,4 Tae-Hyung Kim,5 Jin Woo Kim,6 Woo Jin Kim,7 Yeon-Mok Oh,8 Don D Sin,9 Seong Yong Lim,10,* Sang-Do Lee8,* On behalf of the KOLD Study Group 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; 2Biostatistics Team, Samsung Biomedical Research Institute, Seoul, Korea; 3Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Medical Center, Seoul, Korea; 4Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea; 5Division of Pulmonary and Critical Care Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Gyeonggi-do, Korea; 6Division of Pulmonology, Department of Internal Medicine, Uijeongbu St Mary’s Hospital, Gyunggi-do, Korea; 7Department of Internal Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Korea; 8Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; 9Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, BC, Canada; 10Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea *These authors contributed equally to this work Background: COPD patients with increased airway eosinophilic inflammation show a favorable response to inhaled corticosteroids (ICS in combination with a long-acting bronchodilator. Recent studies have demonstrated a significant correlation of sputum eosinophilia with blood eosinophils and periostin. We investigated whether high blood eosinophils and plasma periostin were associated

  4. Alpha-synuclein in cutaneous small nerve fibers

    Directory of Open Access Journals (Sweden)

    Siepmann T


    Full Text Available Timo Siepmann,1 Ben Min-Woo Illigens,2 Kristian Barlinn1 1Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; 2Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA Abstract: Despite progression in the development of pharmacological therapy, treatment of alpha synucleinopathies, such as Parkinson’s disease (PD and some atypical parkinsonism syndromes, is still challenging. To date, our knowledge of the mechanisms whereby the pathological form of alpha-synuclein causes structural and functional damage to the nervous system is limited and, consequently, there is a lack of specific diagnostic tools to evaluate pathology in these patients and differentiate PD from other neurodegenerative proteinopathies. Recent studies indicated that alpha-synuclein deposition in cutaneous small nerve fibers assessed by skin biopsies might be a valid disease marker of PD and facilitate early differentiation of PD from atypical parkinsonism syndromes. This observation is relevant since early diagnosis may enable timely treatment and improve quality of life. However, challenges include the necessity of standardizing immunohistochemical analysis techniques and the identification of potential distinct patterns of intraneural alpha-synuclein deposition among synucleinopathies. In this perspective, we explore the scientific and clinical opportunities arising from alpha-synuclein assessment using skin biopsies. These include elucidation of the peripheral nervous system pathology of PD and other synucleinopathies, identification of novel targets to study response to neuroprotective treatment, and improvement of clinical management. Furthermore, we discuss future challenges in exploring the diagnostic value of skin biopsy assessment for alpha-synuclein deposition and implementing the technique in clinical practice. Keywords: Parkinson’s disease, diagnosis, skin

  5. Prevalence of colorectal adenomatous polyps in patients with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Chun EM


    Full Text Available Eun Mi Chun, Seo Woo Kim, So Yeon Lim Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Republic of Korea Background: Colorectal adenomatous polyps are precancerous lesions of colorectal cancer. The aim of this study was to assess the prevalence of colorectal adenomatous polyps in chronic obstructive pulmonary disease (COPD patients and determine whether COPD is associated with colorectal malignant potential.Methods: Subjects who had undergone post-bronchodilator spirometry and colonoscopy and were 40 years or older were selected from the hospital database. COPD was defined as a spirometry in which the ratio of forced expiratory volume in 1 second (FEV1 and forced vital capacity (FVC is <0.7 in post-bronchodilator spirometry. The non-COPD group was matched for both age and sex, and were defined as having an FEV1, FVC, and FEV1/FVC ≥0.7 in spirometry. Finally, 333 patients were retrospectively reviewed; of this group, 82 patients had COPD.Results: Among the subjects, 201 patients (60% were nonsmokers, while 78 (23% were current smokers. The prevalence of colorectal adenomatous polyps was 39% (98/251 in the non-COPD group and 66% (54/82 in the COPD group. Among 54 patients with adenomatous polyps in the COPD group, 47 had tubular adenoma and seven had villous adenoma. Multiple logistic regression analyses revealed that only COPD patients whom matched to the criteria of COPD by pulmonary function test (odds ratio 2.1, 95% confidence interval: 1.1–3.8; P=0.019 were independently associated with colorectal malignant potential.Conclusion: The risk of colorectal malignant potential in the COPD group was higher than in the non-COPD group. We may suggest that COPD patients should consider regular colonoscopic evaluation to screen for premalignant colon polyps regardless of smoking. Keywords: COPD, colorectal adenomatous polyp, smoking, chronic obstructive pulmonary

  6. Stealth nanotubes: strategies of shielding carbon nanotubes to evade opsonization and improve biodistribution

    Directory of Open Access Journals (Sweden)

    Kotagiri N


    Full Text Available Nalinikanth Kotagiri,1–4 Jin-Woo Kim1–31Bio/Nano Technology Laboratory, Institute for Nanoscience and Engineering, 2Department of Biological and Agricultural Engineering, 3Cell and Molecular Biology Graduate Program, University of Arkansas, Fayetteville, AR, USA; 4Optical Radiology Laboratory, Department of Radiology, Washington University School of Medicine, St Louis, MO, USAAbstract: Carbon nanotubes (CNTs have recently been in the limelight for their potential role in disease diagnostics and therapeutics, as well as in tissue engineering. Before these medical applications can be realized, there is a need to address issues like opsonization, phagocytosis by macrophages, and sequestration to the liver and spleen for eventual elimination from the body; along with equally important issues such as aqueous solubility, dispersion, biocompatibility, and biofunctionalization. CNTs have not been shown to be able to evade such biological obstacles, which include their nonspecific attachments to cells and other biological components in the bloodstream, before reaching target tissues and cells in vivo. This will eventually determine their longevity in circulation and clearance rate from the body. This review article discusses the current status, challenges, practical strategies, and implementations of coating CNTs with biocompatible and opsonin-resistant moieties, rendering CNTs transparent to opsonins and deceiving the innate immune response to make believe that the CNTs are not foreign. A holistic approach to the development of such "stealth" CNTs is presented, which encompasses not only several biophysicochemical factors that are not limited to surface treatment of CNTs, but also extraneous biological factors such as the protein corona formation that inevitably controls the in vivo fate of the particles. This review also discusses the present and potential applications, along with the future directions, of CNTs and their hybrid

  7. High coronary calcium score and post-procedural CK-MB are noninvasive predictors of coronary stent restenosis

    Directory of Open Access Journals (Sweden)

    Lee JB


    Full Text Available Jae-Beom Lee,1 Yun-Seok Choi,2 Woo-Baek Chung,2 Ami Kwon,2 Chul-Soo Park,2 Man-Young Lee2 1Anyang Sam Hospital, 2Division of Cardiology, Department of Internal Medicine, Youido St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Purpose: High coronary calcium score (CCS and post-procedural cardiac enzyme may be related with poor outcomes in patients with coronary stent implantation. Methods: A total of 1,072 patients (63.2% male, mean age: 61.7±10.3 years who underwent coronary multi-detect computed tomography at index procedure and follow-up coronary angiography (CAG after drug-eluting stent (DES were divided into two groups: those with and without target lesion revascularization (TLR; >50% reduction in luminal stent diameter or angina symptoms on follow-up CAG. The CCSs for predicting stent revascularization were elucidated. Results: There were no significant differences between the two groups with regard to risk factors. The initial CCS was significantly higher in the TLR group (1,102.4±743.7 vs 345.8±51.05, P=0.04. After adjustment of significant factors for TLR, only CCS and post-procedural creatine kinase MB form (CK-MB elevation were significant predictors of coronary artery TLR. Receiver operation curve revealed that >800 in CCS had 69% in sensitivity and 88% in specificity about predicting the TLR. Conclusion: High CCS with post-procedural CK-MB might be the useful predictors for TLR after DES implantation. Keywords: coronary restenosis, drug-eluting stents, calcium, creatine kinase

  8. The 2002 HBR list. Breakthrough ideas for today's business agenda. (United States)


    In the last year, war broke out, the economy took a nosedive, and an alarming number of businesses went belly up. Thus it is with some urgency that we bring you this year's list of the seven best new business ideas to help you find your way through these complex times. History Returns. Many thought that the fall of the Berlin Wall marked the beginning of a new world order, one in which history didn't matter. But September 11, 2001, put an end to that theory. And it raised serious questions about globalization, security, and strategy. Enter the Everyday Leader--at Last. CEOs are used to getting all the glory, but leaders outside the limelight--middle managers and tempered radicals--are beginning to receive the attention they deserve. The Internet Is Not About You. The real value of the Internet may lie less in connecting individuals than in connecting databases, servers, and devices--a web not of people but of machines. Mind Your Behavior. Behavioral scientists are beginning to be able to accurately predict the ways individuals and crowds will respond to stimuli, and the implications for business are profound. Don't Delight Your Customers Away. Companies have wooed and coddled customers for too long. The truth is, people delight in being teased and are repelled by those who try too hard to befriend them. Games Are for Losers. Financial game playing and verbal politicking are seriously damaging businesses. Honesty is more than an admirable virtue; it's the foundation of every lasting enterprise. Three Cheers for Creativity (Sometimes). Creativity and best-practice replication are fundamentally different undertakings. Managers who mix the two achieve creativity that is merely incremental and replication that is sadly inept.

  9. Enhanced oral bioavailability of valsartan using a polymer-based supersaturable self-microemulsifying drug delivery system

    Directory of Open Access Journals (Sweden)

    Yeom DW


    Full Text Available Dong Woo Yeom,1,* Bo Ram Chae,2,* Ho Yong Son,1 Jin Han Kim,1 Jun Soo Chae,1 Seh Hyon Song,2 Dongho Oh,2 Young Wook Choi1 1College of Pharmacy, Chung-Ang University, Seoul, 2Daewon Pharm. Co., Ltd, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: A novel, supersaturable self-microemulsifying drug delivery system (S-SMEDDS was successfully formulated to enhance the dissolution and oral absorption of valsartan (VST, a poorly water-soluble drug, while reducing the total quantity for administration. Poloxamer 407 is a selectable, supersaturating agent for VST-containing SMEDDS composed of 10% Capmul® MCM, 45% Tween® 20, and 45% Transcutol® P. The amounts of SMEDDS and Poloxamer 407 were chosen as formulation variables for a 3-level factorial design. Further optimization was established by weighting different levels of importance on response variables for dissolution and total quantity, resulting in an optimal S-SMEDDS in large quantity (S-SMEDDS_LQ; 352 mg in total and S-SMEDDS in reduced quantity (S-SMEDDS_RQ; 144.6 mg in total. Good agreement was observed between predicted and experimental values for response variables. Consequently, compared with VST powder or suspension and SMEDDS, both S-SMEDDS_LQ and S-SMEDDS_RQ showed excellent in vitro dissolution and in vivo oral bioavailability in rats. The magnitude of dissolution and absorption-enhancing capacities using quantity-based comparisons was in the order S-SMEDDS_RQ > S-SMEDDS_LQ > SMEDDS > VST powder or suspension. Thus, we concluded that, in terms of developing an effective SMEDDS preparation with minimal total quantity, S-SMEDDS_RQ is a promising candidate. Keywords: valsartan, SMEDDS, supersaturation, factorial design, optimization, bio­availability 

  10. Cationic PLGA/Eudragit RL nanoparticles for increasing retention time in synovial cavity after intra-articular injection in knee joint

    Directory of Open Access Journals (Sweden)

    Kim SR


    Full Text Available Sung Rae Kim,1 Myoung Jin Ho,2 Eugene Lee,3 Joon Woo Lee,3 Young Wook Choi,1 Myung Joo Kang21College of Pharmacy, Chung-Ang University, Dongjak-gu, Seoul, 2College of Pharmacy, Dankook University, Dongnam-gu, Cheonan, Chungnam, 3Department of Radiology, Seoul National University Bundang Hospital, Bundang-gu, Seongnam, Gyeonggi-do, South KoreaAbstract: Positively surface-charged poly(lactide-co-glycolide (PLGA/Eudragit RL nanoparticles (NPs were designed to increase retention time and sustain release profile in joints after intra-articular injection, by forming micrometer-sized electrostatic aggregates with hyaluronic acid, an endogenous anionic polysaccharide found in high amounts in synovial fluid. The cationic NPs consisting of PLGA, Eudragit RL, and polyvinyl alcohol were fabricated by solvent evaporation technique. The NPs were 170.1 nm in size, with a zeta potential of 21.3 mV in phosphate-buffered saline. Hyperspectral imaging (CytoViva® revealed the formation of the micrometer-sized filamentous aggregates upon admixing, due to electrostatic interaction between NPs and the polysaccharides. NPs loaded with a fluorescent probe (1,1'-dioctadecyl-3,3,3',3' tetramethylindotricarbocyanine iodide, DiR displayed a significantly improved retention time in the knee joint, with over 50% preservation of the fluorescent signal 28 days after injection. When DiR solution was injected intra-articularly, the fluorescence levels rapidly decreased to 30% of the initial concentration within 3 days in mice. From these findings, we suggest that PLGA-based cationic NPs could be a promising tool for prolonged delivery of therapeutic agents in joints selectively.Keywords: PLGA, Eudragit RL, hyaluronic acid, cationic nanoparticles, intra-articular injection, electrostatic interaction

  11. E-Cigarette Social Media Messages: A Text Mining Analysis of Marketing and Consumer Conversations on Twitter. (United States)

    Lazard, Allison J; Saffer, Adam J; Wilcox, Gary B; Chung, Arnold DongWoo; Mackert, Michael S; Bernhardt, Jay M


    As the use of electronic cigarettes (e-cigarettes) rises, social media likely influences public awareness and perception of this emerging tobacco product. This study examined the public conversation on Twitter to determine overarching themes and insights for trending topics from commercial and consumer users. Text mining uncovered key patterns and important topics for e-cigarettes on Twitter. SAS Text Miner 12.1 software (SAS Institute Inc) was used for descriptive text mining to reveal the primary topics from tweets collected from March 24, 2015, to July 3, 2015, using a Python script in conjunction with Twitter's streaming application programming interface. A total of 18 keywords related to e-cigarettes were used and resulted in a total of 872,544 tweets that were sorted into overarching themes through a text topic node for tweets (126,127) and retweets (114,451) that represented more than 1% of the conversation. While some of the final themes were marketing-focused, many topics represented diverse proponent and user conversations that included discussion of policies, personal experiences, and the differentiation of e-cigarettes from traditional tobacco, often by pointing to the lack of evidence for the harm or risks of e-cigarettes or taking the position that e-cigarettes should be promoted as smoking cessation devices. These findings reveal that unique, large-scale public conversations are occurring on Twitter alongside e-cigarette advertising and promotion. Proponents and users are turning to social media to share knowledge, experience, and questions about e-cigarette use. Future research should focus on these unique conversations to understand how they influence attitudes towards and use of e-cigarettes. ©Allison J Lazard, Adam J Saffer, Gary B Wilcox, Arnold DongWoo Chung, Michael S Mackert, Jay M Bernhardt. Originally published in JMIR Public Health and Surveillance (, 12.12.2016.

  12. Variable Mixed Orbital Character in the Photoelectron Angular Distribution of NO_{2} (United States)

    Laws, Benjamin A.; Cavanagh, Steven J.; Lewis, Brenton R.; Gibson, Stephen T.


    NO_{2} a key component of photochemical smog and an important species in the Earth's atmosphere, is an example of a molecule which exhibits significant mixed orbital character in the HOMO. In photoelectron experiments the geometric properties of the parent anion orbital are reflected in the photoelectron angular distribution (PAD), an area of research that has benefited largely from the ability of velocity-map imaging (VMI) to simultaneously record both the energetic and angular information, with 100% collection efficiency. Photoelectron spectra of NO_{2}^{-}, taken over a range of wavelengths (355nm-520nm) with the ANU's VMI spectrometer, reveal an anomalous jump in the anisotropy parameter near threshold. Consequently, the orbital behavior of NO_{2}^{-} appears to be quite different near threshold compared to detachment at higher photon energies. This surprising effect is due to the Wigner Threshold law, which causes p orbital character to dominate the photodetachment cross-section near threshold, before the mixed s/d orbital character becomes significant at higher electron kinetic energies. By extending recent work on binary character models to form a more general expression, the variable mixed orbital character of NO_{2}^{-} is able to be described. This study provides the first multi-wavelength NO_{2} anisotropy data, which is shown to be in decent agreement with much earlier zero-core model predictions of the anisotropy parameter. K. J. Reed, A. H. Zimmerman, H. C. Andersen, and J. I. Brauman, J. Chem. Phys. 64, 1368, (1976). doi:10.1063/1.432404 D. Khuseynov, C. C. Blackstone, L. M. Culberson, and A. Sanov, J. Chem. Phys. 141, 124312, (2014). doi:10.1063/1.4896241 W. B. Clodius, R. M. Stehman, and S. B. Woo, Phys. Rev. A. 28, 760, (1983). doi:10.1103/PhysRevA.28.760 Research supported by the Australian Research Council Discovery Project Grant DP160102585

  13. Application of linear scheduling method (LSM) for nuclear power plant (NPP) construction

    International Nuclear Information System (INIS)

    Kim, Woojoong; Ryu, Dongsoo; Jung, Youngsoo


    Highlights: • Mixed use of linear scheduling method with traditional CPM is suggested for NPP. • A methodology for selecting promising areas for LSM application is proposed. • A case-study is conducted to validate the proposed LSM selection methodology. • A case-study of reducing NPP construction duration by using LSM is introduced. - Abstract: According to a forecast, global energy demand is expected to increase by 56% from 2010 to 2040 (EIA, 2013). The nuclear power plant construction market is also growing with sharper competition. In nuclear power plant construction, scheduling is one of the most important functions due to its large size and complexity. Therefore, it is crucial to incorporate the ‘distinct characteristics of construction commodities and the complex characteristics of scheduling techniques’ (Jung and Woo, 2004) when selecting appropriate schedule control methods for nuclear power plant construction. However, among various types of construction scheduling techniques, the traditional critical path method (CPM) has been used most frequently in real-world practice. In this context, the purpose of this paper is to examine the viability and effectiveness of linear scheduling method (LSM) applications for specific areas in nuclear power plant construction. In order to identify the criteria for selecting scheduling techniques, the characteristics of CPM and LSM were compared and analyzed first through a literature review. Distinct characteristics of nuclear power plant construction were then explored by using a case project in order to develop a methodology to select effective areas of LSM application to nuclear power plant construction. Finally, promising areas for actual LSM application are suggested based on the proposed evaluation criteria and the case project. Findings and practical implications are discussed for further implementation

  14. Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Lee JH


    Full Text Available Ji Han Lee,1 Won Sang Jung,2 Woo Hee Choi,3 Hyun Kook Lim4 1Washington University in St Louis, St Louis, MO, USA; 2Department of Radiology, 3Department of Nuclear Medicine, 4Department of Psychiatry, Saint Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, South Korea Objective: Among patients with Alzheimer’s disease (AD, sleep disturbances are common and serious noncognitive symptoms. Previous studies of AD patients have identified deformations in the brain stem, which may play an important role in the regulation of sleep. The aim of this study was to further investigate the relationship between sleep disturbances and alterations in brain stem morphology in AD.Materials and methods: In 44 patients with AD and 40 healthy elderly controls, sleep disturbances were measured using the Neuropsychiatry Inventory sleep subscale. We employed magnetic resonance imaging-based automated segmentation tools to examine the relationship between sleep disturbances and changes in brain stem morphology.Results: Analyses of the data from AD subjects revealed significant correlations between the Neuropsychiatry Inventory sleep-subscale scores and structural alterations in the left posterior lateral region of the brain stem, as well as normalized brain stem volumes. In addition, significant group differences in posterior brain stem morphology were observed between the AD group and the control group.Conclusion: This study is the first to analyze an association between sleep disturbances and brain stem morphology in AD. In line with previous findings, this study lends support to the possibility that brain stem structural abnormalities might be important neurobiological mechanisms underlying sleep disturbances associated with AD. Further longitudinal research is needed to confirm these findings. Keywords: Alzheimer’s disease, sleep, brain stem, MRI, shape analysis

  15. What is a free customer worth? Armchair calculations of nonpaying customers' value can lead to flawed strategies. (United States)

    Gupta, Sunil; Mela, Carl F


    Free customers who are subsidized by paying customers are essential to a vast array of businesses, such as media companies, employment services, and even IT providers. But because they generate revenue only indirectly, figuring out the true value of those customers--and how much attention to devote them--has always been a challenge. Traditional customer-valuation models don't help; they focus exclusively on paying customers and largely ignore network effects, or how customers help draw other customers to a business. Now a new model, devised by professors Gupta, of Harvard Business School, and Mela, of Fuqua School of Business, takes into account not only direct network effects (where buyers attract more buyers or sellers more sellers) but also indirect network effects (where buyers attract more sellers or vice versa) . The model calculates the precise long-term impact of each additional free customer on a company's profits, factoring in the degree to which he or she brings in other customers--whether free or paying--and the ripple effect of those customers. The model helped an online auction house make several critical decisions. The business made its money on fees charged to sellers but recognized that its free customers--its buyers--were valuable, too. As competition heated up, the company worried that it wasn't wooing enough buyers. Using the model, the business discovered that the network effects of buyers were indeed large and that those customers were worth over $1,000 each--much more than had been assumed. Armed with that information, the firm increased its research on buyers, invested more in targeting them with ads, and improved their experience. The model also helped the company identify the effects of various pricing strategies on sellers, showing that they became less price-sensitive over time. As a result, the company raised the fees it charged them as well.

  16. Quantitative measurements of C-reactive protein using silicon nanowire arrays

    Directory of Open Access Journals (Sweden)

    Min-Ho Lee


    Full Text Available Min-Ho Lee, Kuk-Nyung Lee, Suk-Won Jung, Won-Hyo Kim, Kyu-Sik Shin, Woo-Kyeong SeongKorea Electronics Technology Institute, Gyeonggi, KoreaAbstract: A silicon nanowire-based sensor for biological application showed highly desirable electrical responses to either pH changes or receptor-ligand interactions such as protein disease markers, viruses, and DNA hybridization. Furthermore, because the silicon nanowire can display results in real-time, it may possess superior characteristics for biosensing than those demonstrated in previously studied methods. However, despite its promising potential and advantages, certain process-related limitations of the device, due to its size and material characteristics, need to be addressed. In this article, we suggest possible solutions. We fabricated silicon nanowire using a top-down and low cost micromachining method, and evaluate the sensing of molecules after transfer and surface modifications. Our newly designed method can be used to attach highly ordered nanowires to various substrates, to form a nanowire array device, which needs to follow a series of repetitive steps in conventional fabrication technology based on a vapor-liquid-solid (VLS method. For evaluation, we demonstrated that our newly fabricated silicon nanowire arrays could detect pH changes as well as streptavidin-biotin binding events. As well as the initial proof-of-principle studies, C-reactive protein binding was measured: electrical signals were changed in a linear fashion with the concentration (1 fM to 1 nM in PBS containing 1.37 mM of salts. Finally, to address the effects of Debye length, silicon nanowires coupled with antigen proteins underwent electrical signal changes as the salt concentration changed.Keywords: silicon nanowire array, C-reactive protein, vapor-liquid-solid method

  17. PCI resistant light water reactor fuel cladding

    International Nuclear Information System (INIS)

    Foster, J.P.; Sabol, G.P.


    A tubular nuclear fuel element cladding tube is described, the fuel element cladding tube forming the entire fuel element cladding and consisting of: a single continuous wall, the single continuous wall consisting of a single alloy selected from the group consisting of zirconium base alloys, A, B, C, D, and E; the single continuous wall characterized by a cold worked and stress relieved microstructure throughout; wherein the zirconium base alloy A contains 0.2 - 0.6 w/o Sn, 0.03 - 0.11 w/o sum of Fe and Cr, section 600 ppm O and section 1500 ppm total impurities; the zirconium base alloy B contains 0.1 - 0.6 w/oo Sn, 0.04 - 0.24 w/o Fe, 0.05 - 0.15 w/o Cr, section 0.08 w/o Ni, section 600 ppm O and section 1500 ppm total impurities; the zirconium base alloy C contains 1.2 - 1.7 w/o Sn, 0.04 - 0.24 w/o Fe, 0.05 - 0.15 w/o Cr, section 0.08 w/o Ni, section 600 ppm O, and section 1500 ppm total impurities; the zirconium base alloy D contains 0.15 - 0.6 w/o Sn, 0.15 - 0.5 w/o Fe, section 600 ppm O, and section 1500 ppm total impurities; and the zirconium base alloy E contains 0.4 - 0.6 w/o Sn, 0.1 - 0.3 w/o Fe, 0.03 - 0.07 w/o Ni, section 600 ppm O, and section 1500 ppm total impurities

  18. The response and recovery of the Arabidopsis thaliana transcriptome to phosphate starvation

    KAUST Repository

    Woo, Jongchan


    Background: Over application of phosphate fertilizers in modern agriculture contaminates waterways and disrupts natural ecosystems. Nevertheless, this is a common practice among farmers, especially in developing countries as abundant fertilizers are believed to boost crop yields. The study of plant phosphate metabolism and its underlying genetic pathways is key to discovering methods of efficient fertilizer usage. The work presented here describes a genome-wide resource on the molecular dynamics underpinning the response and recovery in roots and shoots of Arabidopsis thaliana to phosphate-starvation.Results: Genome-wide profiling by micro- and tiling-arrays (accessible from GEO: GSE34004) revealed minimal overlap between root and shoot transcriptomes suggesting two independent phosphate-starvation regulons. Novel gene expression patterns were detected for over 1000 candidates and were classified as either initial, persistent, or latent responders. Comparative analysis to AtGenExpress identified cohorts of genes co-regulated across multiple stimuli. The hormone ABA displayed a dominant role in regulating many phosphate-responsive candidates. Analysis of co-regulation enabled the determination of specific versus generic members of closely related gene families with respect to phosphate-starvation. Thus, among others, we showed that PHR1-regulated members of closely related phosphate-responsive families (PHT1;1, PHT1;7-9, SPX1-3, and PHO1;H1) display greater specificity to phosphate-starvation than their more generic counterparts. Conclusion: Our results uncover much larger, staged responses to phosphate-starvation than previously described. To our knowledge, this work describes the most complete genome-wide data on plant nutrient stress to-date. 2012 Woo et al.; licensee BioMed Central Ltd.

  19. Summary of the 1. Asian Workshop on the Ethical Dimensions of the Radiological Protection System

    International Nuclear Information System (INIS)

    Cho, Kun-Woo


    Kun-Woo Cho gave a panorama of the 1. Asian Workshop held in Daejeon on 27-28 August 2013 and he focused mainly on the results of the discussions carried out within the three Working Groups. In each group the discussion initially addressed on two questions: What issues of radiation protection refer to ethics? What are the ethical values (explicit and implicit), which underlie the system of radiological protection? WG 1 focused on the fact that the RP system includes judgments that refer to ethical values, but they are implicitly and un-clearly presented in the ICRP recommendations; on the dialogues about the foundation, objectives and rationality of RP system, which should be pushed to facilitate the understanding of the system for RP specialists and stakeholders; and on RP culture and wise behaviours vis-a-vis radiation, which should be promoted in the society. WG 2 discussed the need of ethical consideration in the system of radiological protection; the need to revisit whether individual rights to happiness or justice had been respected; the need to provide more rationales to support important judgments in the RP system, and the need to refine the term 'members of the public' to distinguish informed individuals with certain benefit in return. WG 3 noted that strong parallels between bio-ethics and RP ethics exist. It has also agreed that simplicity, education and communication efforts are required in the RP system to overcome public misunderstanding and to enhance acceptability. With respect to the values of RP ethics attention was given to tolerance of people's views, human dignity, justice, respect for persons, beneficence, prudence, understanding/simplicity and well-being. The presentation reported a view of the conclusions obtained from the 1. Asian Workshop focused on communication, well-being, tolerability and acceptability of risk as the main issues addressed

  20. Quasi-linear viscoelastic properties of the human medial patello-femoral ligament. (United States)

    Criscenti, G; De Maria, C; Sebastiani, E; Tei, M; Placella, G; Speziali, A; Vozzi, G; Cerulli, G


    The evaluation of viscoelastic properties of human medial patello-femoral ligament is fundamental to understand its physiological function and contribution as stabilizer for the selection of the methods of repair and reconstruction and for the development of scaffolds with adequate mechanical properties. In this work, 12 human specimens were tested to evaluate the time- and history-dependent non linear viscoelastic properties of human medial patello-femoral ligament using the quasi-linear viscoelastic (QLV) theory formulated by Fung et al. (1972) and modified by Abramowitch and Woo (2004). The five constant of the QLV theory, used to describe the instantaneous elastic response and the reduced relaxation function on stress relaxation experiments, were successfully evaluated. It was found that the constant A was 1.21±0.96MPa and the dimensionless constant B was 26.03±4.16. The magnitude of viscous response, the constant C, was 0.11±0.02 and the initial and late relaxation time constants τ1 and τ2 were 6.32±1.76s and 903.47±504.73s respectively. The total stress relaxation was 32.7±4.7%. To validate our results, the obtained constants were used to evaluate peak stresses from a cyclic stress relaxation test on three different specimens. The theoretically predicted values fit the experimental ones demonstrating that the QLV theory could be used to evaluate the viscoelastic properties of the human medial patello-femoral ligament. Copyright © 2015 Elsevier Ltd. All rights reserved.

  1. Forensic aspects of sexual harassment. (United States)

    Rosman, J P; McDonald, J J


    Sexual harassment law presents a complex set of issues not only for lawyers but also for psychiatrists in their roles both as evaluators and clinicians. Judge Reinhardt of the US Court of Appeals for the 9th Circuit, summed up these complexities: "We tend these days, far more than in earlier times, to find our friends, lovers, and even mates in the workplace. We ... often discover that our interests and values are closer to those of our colleagues or fellow employees than to those of people we meet in connection with other activities. In short, increased proximity breeds increased volitional sexual activity." On the other hand, he notes that Title VII "entitles individuals to a workplace that is free from the evil of sexual intimidation or repression. It is frequently difficult to reconcile the two competing values." He goes on to ask, "When does a healthy constructive interest in romance become sexual harassment? To what extent is pursuit of a co-worker proper but of a subordinate forbidden? Is wooing or courting a thing of the past? Must a suitor cease his attentions at the first sign of disinterest or resistance? Must there be an express agreement before the person seeking romance may even hold the hand of the subject of his affection? Is it now verboten to steal a kiss? In the workplace? Everywhere? Under all circumstances or only some? Has the art of romantic persuasion lost its charm? Questions relating to love and sex are among the most difficult for society to answer." The US Supreme Court has stressed the need for common sense in evaluating cases of sexual harassment. Perhaps psychiatrists can play a sobering role in developing answers to these questions.

  2. Model study on acidifying wet deposition in East Asia during wintertime (United States)

    Han, Zhiwei; Ueda, Hiromasa; Sakurai, Tatsuya

    A regional air quality model (RAQM) has been developed and applied together with an aerosol model to investigate the states and characteristics of wet deposition in East Asia in December 2001. Model simulation is performed with monthly based emission inventory [Streets, D.G., Bond, T.C., Carmichael, G.R., Fernandes, S.D., Fu, Q., He, D., Klimont, Z., Nelson, S. M., Tsai, N.Y., Wang, M.Q., Woo, J.-H., Yarber, K.F., 2003. An inventory of gaseous and primary emissions in Asia in the year 2000. Journal of Geophysical Research 108(D21), 8809] and meteorological fields derived from MM5. Model results are compared with extensive monitoring data including relevant gaseous species and ions in precipitation. The validation demonstrates that this model system is able to represent most of the major physical and chemical processes involved in acid deposition and reproduces concentrations reasonably well, within a factor of 2 of observations in general. The study shows that the regions with pH less than 4.5 are mainly located in southwestern China, parts of the Yangtze Delta, the Yellow Sea and the Korean peninsula, indicating wide regions of acid precipitation in East Asia in wintertime. Japan islands mainly exhibit pH values of 4.5-5.0, whereas over wide areas of northern China, pH values are relatively high (⩾5.0) due to neutralization by alkaline materials such as calcium-laden particles and ammonia, which are more abundant in northern China than that in southern China. While acid rain over most of China is still characterized by sulfur-induced type, considerable areas of eastern China and the western Pacific Rim are found to be more affected by nitric acid than sulfuric acid in acidification of precipitation, which is supposed to result from a combined effect of variations in photochemistry and emission, suggesting the increasing importance of NO x emission in these regions.

  3. Application of linear scheduling method (LSM) for nuclear power plant (NPP) construction

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Woojoong, E-mail: [Central Research Institute, Korea Hydro and Nuclear Power Co., Ltd, Daejeon 305-343 (Korea, Republic of); Ryu, Dongsoo, E-mail: [Central Research Institute, Korea Hydro and Nuclear Power Co., Ltd, Daejeon 305-343 (Korea, Republic of); Jung, Youngsoo, E-mail: [College of Architecture, Myongji University, Yongin 449-728 (Korea, Republic of)


    Highlights: • Mixed use of linear scheduling method with traditional CPM is suggested for NPP. • A methodology for selecting promising areas for LSM application is proposed. • A case-study is conducted to validate the proposed LSM selection methodology. • A case-study of reducing NPP construction duration by using LSM is introduced. - Abstract: According to a forecast, global energy demand is expected to increase by 56% from 2010 to 2040 (EIA, 2013). The nuclear power plant construction market is also growing with sharper competition. In nuclear power plant construction, scheduling is one of the most important functions due to its large size and complexity. Therefore, it is crucial to incorporate the ‘distinct characteristics of construction commodities and the complex characteristics of scheduling techniques’ (Jung and Woo, 2004) when selecting appropriate schedule control methods for nuclear power plant construction. However, among various types of construction scheduling techniques, the traditional critical path method (CPM) has been used most frequently in real-world practice. In this context, the purpose of this paper is to examine the viability and effectiveness of linear scheduling method (LSM) applications for specific areas in nuclear power plant construction. In order to identify the criteria for selecting scheduling techniques, the characteristics of CPM and LSM were compared and analyzed first through a literature review. Distinct characteristics of nuclear power plant construction were then explored by using a case project in order to develop a methodology to select effective areas of LSM application to nuclear power plant construction. Finally, promising areas for actual LSM application are suggested based on the proposed evaluation criteria and the case project. Findings and practical implications are discussed for further implementation.

  4. Estimation of health state utilities in breast cancer

    Directory of Open Access Journals (Sweden)

    Kim SH


    Full Text Available Seon-Ha Kim,1 Min-Woo Jo,2 Minsu Ock,2 Hyeon-Jeong Lee,2 Jong-Won Lee3,4 1Department of Nursing, College of Nursing, Dankook University, Cheonan, 2Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, 3Department of Breast and Endocrine Surgery, Asan Medical Center, Seoul, 4Department of Surgery, University of Ulsan College of Medicine, Seoul, South Korea Purpose: The aim of this study is to determine the utility of breast cancer health states using the standard gamble (SG and visual analog scale (VAS methods in the Korean general population.Materials and methods: Eight hypothetical breast cancer health states were developed based on patient education material and previous publications. Data from 509 individuals from the Korean general population were used to evaluate breast cancer health states using the VAS and the SG methods, which were obtained via computer-assisted personal interviews. Mean utility values were calculated for each human papillomavirus (HPV-related health state.Results: The rank of health states was identical between two valuation methods. SG values were higher than VAS values in all health states. The utility values derived from SG were 0.801 (noninvasive breast cancer with mastectomy and followed by reconstruction, 0.790 (noninvasive breast cancer with mastectomy only, 0.779 (noninvasive breast cancer with breast-conserving surgery and radiation therapy, 0.731 (invasive breast cancer with surgery, radiation therapy, and/or chemotherapy, 0.610 (locally advanced breast cancer with radical mastectomy with radiation therapy, 0.587 (inoperable locally advanced breast cancer, 0.496 (loco-regional recurrent breast cancer, and 0.352 (metastatic breast cancer.Conclusion: Our findings might be useful for economic evaluation of breast cancer screening and interventions in general populations. Keywords: breast neoplasm, Korea, quality-adjusted life years, quality of life

  5. Committees (United States)


    Leadership Team of the IAHR Committee for Hydraulic Machinery and Systems Eduard EGUSQUIZA, UPC Barcelona, Spain, Chair François AVELLAN, EPFL-LMH, Switzerland, Past Chair Richard K FISHER, Voith Hydro Inc., USA, Past Chair Fidel ARZOLA, Edelca, Venezuela Michel COUSTON, Alstom Hydro, France Niklas DAHLBÄCKCK, Vatenfall, Sweden Normand DESY, Andritz VA TECH Hydro Ltd., Canada Chisachi KATO, University of Tokyo, Japan Andrei LIPEJ, Turboinstitut, Slovenija Torbjørn NIELSEN, NTNU, Norway Romeo SUSAN-RESIGA, 'Politehnica' University Timisoara, Romania Stefan RIEDELBAUCH, Stuggart University, Germany Albert RUPRECHT, Stuttgart University, Germany Qing-Hua SHI, Dong Fang Electrical Machinery Co., China Geraldo TIAGO, Universidade Federal de Itajubá, Brazil International Advisory Committee Shouqi YUAN (principal) Jiangsu University China QingHua SHI (principal) Dong Fang Electrical Machinery Co. China Fidel ARZOLA EDELCA Venezuela Thomas ASCHENBRENNER Voith Hydro GmbH & Co. KG Germany Anton BERGANT Litostroj Power doo Slovenia B C BHAOYAL Research & Technology Centre India Hermod BREKKE NTNU Norway Stuart COULSON Voith Hydro Inc. USA Paul COOPER Fluid Machinery Research Inc USA V A DEMIANOV Power Machines OJSC Russia Bart van ESCH Technische Universiteit Eindhoven Netherland Arno GEHRER Andritz Hydro Graz Austria Akira GOTO Ebara Corporation Japan Adiel GUINZBURG The Boeing Company USA D-H HELLMANN KSB AG Germany Ashvin HOSANGADI Combustion Research and Flow Technology USA Byung-Sun HWANG Korea Institute of Material Science Korea Toshiaki KANEMOTO Kyushu Institute of Technology Japan Mann-Eung KIM Korean Register of Shipping Korea Jiri KOUTNIK Voith Hydro GmbH & Co. KG Germany Jinkook LEE Eaton Corporation USA Young-Ho LEE Korea Maritime University Korea Woo-Seop LIM Hyosung Goodsprings Inc Korea Jun MATSUI Yokohama National University Japan Kazuyoshi Mitsubishi H I Ltd, Japan MIYAGAWA Christophe NICOLET Power Vision Engineering Srl Switzerland Maryse PAGE Hydro

  6. PREFACE: Vibrations at surfaces Vibrations at surfaces (United States)

    Rahman, Talat S.


    Central Florida, Orlando, in March 2010. Several speakers at this meeting were invited to contribute to the special section in this issue. As is clear from the articles in this special section, the phenomenon of vibrations at surfaces continues to be a dynamic field of investigation. In fact, there is a resurgence of effort because the insights provided by surface dynamics are still fundamental to the development of an understanding of the microscopic factors that control surface structure formation, diffusion, reaction and structural stability. Examination of dynamics at surfaces thus complements and supplements the wealth of information that is obtained from real-space techniques such as scanning tunneling microscopy. Vibrational dynamics is, of course, not limited to surfaces. Surfaces are important since they provide immediate deviation from the bulk. They display how lack of symmetry can lead to new structures, new local atomic environments and new types of dynamical modes. Nanoparticles, large molecules and nanostructures of all types, in all kinds of local environments, provide further examples of regions of reduced symmetry and coordination, and hence display characteristic vibrational modes. Given the tremendous advance in the synthesis of a variety of nanostructures whose functionalization would pave the way for nanotechnology, there is even greater need to engage in experimental and theoretical techniques that help extract their vibrational dynamics. Such knowledge would enable a more complete understanding and characterization of these nanoscale systems than would otherwise be the case. The papers presented here provide excellent examples of the kind of information that is revealed by vibrations at surfaces. Vibrations at surface contents Poisoning and non-poisoning oxygen on Cu(410)L Vattuone, V Venugopal, T Kravchuk, M Smerieri, L Savio and M Rocca Modifying protein adsorption by layers of glutathione pre-adsorbed on Au(111)Anne Vallée, Vincent Humblot

  7. Evaluating Dermatology Residency Program Websites. (United States)

    Ashack, Kurt A; Burton, Kyle A; Soh, Jonathan M; Lanoue, Julien; Boyd, Anne H; Milford, Emily E; Dunnick, Cory; Dellavalle, Robert P


    Internet resources play an important role in how medical students access information related to residency programs.Evaluating program websites is necessary in order to provide accurate information for applicants and provide information regarding areas of website improvement for programs. To date, dermatology residency websites (D  WS) have not been evaluated.This paper evaluates dermatology residency websites based on availability of predefined measures. Using the FREIDA (Fellowship and Residency Electronic Interactive Database) Online database, authors searched forall accredited dermatology program websites. Eligible programs were identified through the FREIDA Online database and had a functioning website. Two authors independently extracted data with consensus or third researcher resolution of differences. This data was accessed and archived from July 15th to July 17th, 2015.Primary outcomes measured were presence of content on education, resident and faculty information, program environment, applicant recruitment, schedule, salary, and website quality evaluated using an online tool ( Out of 117 accredited dermatology residencies, 115 had functioning webpages. Of these, 76.5% (75) had direct links found on the FRIEDA Online database. Most programs contained information on education, faculty, program environment, and applicant recruitment. However, website quality and marketing effectiveness were highly variable; most programs were deemed to need improvements in the functioning of their webpages. Also, additional information on current residents and about potential away rotations were lacking from most websites with only 52.2% (60) and 41.7% (48) of programs providing this content, respectively. A majority of dermatology residency websites contained adequate information on many of the factors we evaluated. However, many were lacking in areas that matter to applicants. We hope this report will encourage dermatology residencyprograms

  8. PLGA nanofiber membranes loaded with epigallocatechin-3-O-gallate are beneficial to prevention of postsurgical adhesions

    Directory of Open Access Journals (Sweden)

    Shin YC


    Full Text Available Yong Cheol Shin,1,* Won Jun Yang,1,* Jong Ho Lee,1 Jin-Woo Oh,2 Tai Wan Kim,3 Jong-Chul Park,4 Suong-Hyu Hyon,5 Dong-Wook Han1 1Department of Cogno-Mechatronics Engineering, Pusan National University, Busan, Republic of Korea; 2Department of Nanomaterials Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Busan, Republic of Korea; 3Department of Design, College of Arts, Pusan National University, Busan, Republic of Korea; 4Department of Medical Engineering, Yonsei University College of Medicine, Seoul, Republic of Korea; 5Center for Fiber and Textile Science, Kyoto Institute of Technology, Kyoto, Japan *These authors contributed equally to this work Abstract: This study concentrates on the development of biodegradable nanofiber membranes with controlled drug release to ensure reduced tissue adhesion and accelerated healing. Nanofibers of poly(lactic-co-glycolic acid (PLGA loaded with epigallocatechin-3-O-gallate (EGCG, the most bioactive polyphenolic compound in green tea, were electrospun. The physicochemical and biomechanical properties of EGCG-releasing PLGA (E-PLGA nanofiber membranes were characterized by atomic force microscopy, EGCG release and degradation profiles, and tensile testing. In vitro antioxidant activity and hemocompatibility were evaluated by measuring scavenged reactive oxygen species levels and activated partial thromboplastin time, respectively. In vivo antiadhesion efficacy was examined on the rat peritonea with a surgical incision. The average fiber diameter of E-PLGA membranes was approximately 300–500 nm, which was almost similar to that of pure PLGA equivalents. E-PLGA membranes showed sustained EGCG release mediated by controlled diffusion and PLGA degradation over 28 days. EGCG did not adversely affect the tensile strength of PLGA membranes, whereas it significantly decreased the elastic modulus and increased the strain at break. E-PLGA membranes were significantly effective in

  9. Postoperative pain and patient-controlled epidural analgesia-related adverse effects in young and elderly patients: a retrospective analysis of 2,435 patients

    Directory of Open Access Journals (Sweden)

    Koh JC


    Full Text Available Jae Chul Koh, Young Song, So Yeon Kim, Sooyeun Park, Seo Hee Ko, Dong Woo Han Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, South Korea Abstract: In this retrospective study, data of 2,435 patients who received fentanyl and ropivacaine-based patient-controlled epidural analgesia (PCEA for pain relief after elective surgery under general or spinal anesthesia were reviewed. Differences in postoperative pain, incidence of patient-controlled analgesia (PCA-related adverse effects, and risk factors for the need for rescue analgesics for 48 hours postsurgery in young (age 20–39 years and elderly (age ≥70 years patients were evaluated. Although there were no significant differences in postoperative pain intensity between the two groups until 6 hours postsurgery, younger patients experienced greater postoperative pain intensity compared with older patients 6–48 hours postsurgery. While younger patients exhibited greater incidence of numbness, motor weakness, and discontinuation of PCA postsurgery, elderly patients exhibited greater incidence of hypotension, nausea/vomiting, rescue analgesia, and antiemetic administration. Upon multivariate analysis, low fentanyl dosage and history of smoking were found to be associated with an increased need for rescue analgesia among younger patients, while physical status classification III/IV and thoracic surgery were associated with a decreased need for rescue analgesia among the elderly. Discontinuation of PCA was more frequent among younger patients than the elderly (18.5% vs 13.5%, P=0.001. Reasons for discontinuation of PCA among young and elderly patients, respectively, were nausea and vomiting (6.8% vs 26.6%, numbness or motor weakness (67.8% vs 11.5%, urinary retention (7.4% vs 8.7%, dizziness (2.2% vs 5.2%, and hypotension (3.1% vs 20.3%. In conclusion, PCEA was more frequently associated with numbness, motor

  10. Effectiveness of elastic band-type ankle–foot orthoses on postural control in poststroke elderly patients as determined using combined measurement of the stability index and body weight-bearing ratio

    Directory of Open Access Journals (Sweden)

    Kim JH


    Full Text Available Jong Hyun Kim, Woo Sang Sim, Byeong Hee Won Usability Evaluation Technology Center, Advanced Biomedical and Welfare R&D Group, Korea Institute of Industrial Technology, Cheonan-si, Chungcheongnam-do, South Korea Purpose: Poor recovery of postural stability poststroke is the primary cause of impairment in activities and social participation in elderly stroke survivors. The purpose of our study was to experimentally evaluate the effectiveness of our new elastic ankle–foot orthosis (AFO, compared to a traditional AFO fabricated with hard plastic, in improving postural stability in elderly chronic stroke survivors. Patients and methods: Postural stability was evaluated in ten chronic stroke patients, 55.7±8.43 years old. Postural stability was evaluated using the standardized methods of the Biodex Balance System combined with a foot pressure system, under three experimental conditions, no AFO, rigid plastic AFO, and elastic AFO (E-AFO. The following dependent variables of postural stability were analyzed: plantar pressure under the paretic and nonparetic foot, area of the center of balance (COB and % time spent in each location, distance traveled by the COB away from the body center, distance traveled by the center of pressure, and calculated index of overall stability, as well as indices anterior–posterior and medial–lateral stability. Results: Both AFO designs improved all indices of postural stability. Compared to the rigid plastic AFO, the E-AFO produced additional positive effects in controlling anterior–posterior body sway, equalizing weight bearing through the paretic and nonparetic limbs, and restraining the displacement of the center of pressure and of the COB. Conclusion: Based on our outcomes, we recommend the prescription of E-AFOs as part of a physiotherapy rehabilitation program to promote recovery of postural stability poststroke. When possible, therapeutic outcomes should be documented using the Biodex Balance System and

  11. Titanium dioxide induces apoptotic cell death through reactive oxygen species-mediated Fas upregulation and Bax activation

    Directory of Open Access Journals (Sweden)

    Yoon TH


    Full Text Available Ki-Chun Yoo1, Chang-Hwan Yoon1, Dongwook Kwon2, Kyung-Hwan Hyun1, Soo Jung Woo1, Rae-Kwon Kim1, Eun-Jung Lim1, Yongjoon Suh1, Min-Jung Kim1, Tae Hyun Yoon2, Su-Jae Lee11Laboratory of Molecular Biochemistry, 2Laboratory of Nanoscale Characterization and Environmental Chemistry, Department of Chemistry, Hanyang University, Seoul, Republic of KoreaBackground: Titanium dioxide (TiO2 has been widely used in many areas, including biomedicine, cosmetics, and environmental engineering. Recently, it has become evident that some TiO2 particles have a considerable cytotoxic effect in normal human cells. However, the molecular basis for the cytotoxicity of TiO2 has yet to be defined.Methods and results: In this study, we demonstrated that combined treatment with TiO2 nanoparticles sized less than 100 nm and ultraviolet A irradiation induces apoptotic cell death through reactive oxygen species-dependent upregulation of Fas and conformational activation of Bax in normal human cells. Treatment with P25 TiO2 nanoparticles with a hydrodynamic size distribution centered around 70 nm (TiO2P25–70 together with ultraviolet A irradiation-induced caspase-dependent apoptotic cell death, accompanied by transcriptional upregulation of the death receptor, Fas, and conformational activation of Bax. In line with these results, knockdown of either Fas or Bax with specific siRNA significantly inhibited TiO2-induced apoptotic cell death. Moreover, inhibition of reactive oxygen species with an antioxidant, N-acetyl-L-cysteine, clearly suppressed upregulation of Fas, conformational activation of Bax, and subsequent apoptotic cell death in response to combination treatment using TiO2P25–70 and ultraviolet A irradiation.Conclusion: These results indicate that sub-100 nm sized TiO2 treatment under ultraviolet A irradiation induces apoptotic cell death through reactive oxygen species-mediated upregulation of the death receptor, Fas, and activation of the preapoptotic protein

  12. Agricultural Fragility Estimates Subjected to Volcanic Ash Fall Hazards (United States)

    Ham, H. J.; Lee, S.; Choi, S. H.; Yun, W. S.


    Agricultural Fragility Estimates Subjected to Volcanic Ash Fall Hazards Hee Jung Ham1, Seung-Hun Choi1, Woo-Seok Yun1, Sungsu Lee2 1Department of Architectural Engineering, Kangwon National University, Korea 2Division of Civil Engineering, Chungbuk National University, Korea ABSTRACT In this study, fragility functions are developed to estimate expected volcanic ash damages of the agricultural sector in Korea. The fragility functions are derived from two approaches: 1) empirical approach based on field observations of impacts to agriculture from the 2006 eruption of Merapi volcano in Indonesia and 2) the FOSM (first-order second-moment) analytical approach based on distribution and thickness of volcanic ash observed from the 1980 eruption of Mt. Saint Helens and agricultural facility specifications in Korea. Fragility function to each agricultural commodity class is presented by a cumulative distribution function of the generalized extreme value distribution. Different functions are developed to estimate production losses from outdoor and greenhouse farming. Seasonal climate influences vulnerability of each agricultural crop and is found to be a crucial component in determining fragility of agricultural commodities to an ash fall. In the study, the seasonality coefficient is established as a multiplier of fragility function to consider the seasonal vulnerability. Yields of the different agricultural commodities are obtained from Korean Statistical Information Service to create a baseline for future agricultural volcanic loss estimation. Numerically simulated examples of scenario ash fall events at Mt. Baekdu volcano are utilized to illustrate the application of the developed fragility functions. Acknowledgements This research was supported by a grant 'Development of Advanced Volcanic Disaster Response System considering Potential Volcanic Risk around Korea' [MPSS-NH-2015-81] from the Natural Hazard Mitigation Research Group, Ministry of Public Safety and Security of

  13. A Chinese Chan-based mind–body intervention improves psychological well-being and physical health of community-dwelling elderly: a pilot study

    Directory of Open Access Journals (Sweden)

    Yu R


    Full Text Available Ruby Yu,1 Jean Woo,1 Agnes S Chan,2–4 Sophia L Sze2,3 1Department of Medicine and Therapeutics, 2Department of Psychology, 3Chanwuyi Research Center for Neuropsychological Well-Being, The Chinese University of Hong Kong, New Territories, Hong Kong; 4Henan Songshan Research Institute for Chanwuyi, Henan, People's Republic of China Background: The aim of this study was to explore the potential benefits of the Dejian mind–body intervention (DMBI for psychological and physical health in older Chinese adults. Methods: After confirmation of eligibility, the subjects were invited to receive DMBI once a week for 12 weeks. The intervention involved components of learning self-awareness and self-control, practicing mind–body exercises, and adopting a special vegetarian diet. Intervention-related changes were measured using the Perceived Stress Scale, Geriatric Depression Scale, Pittsburgh Sleep Quality Index, Chinese Constipation Questionnaire, and self-report ratings of health. Indicators of metabolic syndrome and walking speed were also measured. Results: Of the 44 subjects recruited, 42 (54.8% men completed the study, giving an adherence rate of 95%. There was a significant reduction in perceived stress (P<0.05. A significant improvement was also found in systolic blood pressure among those who had abnormally high blood pressure at baseline (P<0.05. Physical fitness as reflected by walking speed was also significantly increased after the intervention (P<0.05. Sleep disturbances were reduced (P<0.01. Self-rated health was significantly enhanced, with the percentage rating very good health increasing from 14.3% at baseline to 42.8% after the intervention (P<0.001. No intervention effect was found for waist circumference, lipids and fasting blood glucose levels, Pittsburgh Sleep Quality Index global score, and constipation measures. Conclusion: The DMBI was feasible and acceptable, and subjects showed some improvements in psychological and physical

  14. The effect of dietary antioxidant on the COPD risk: the community-based KoGES (Ansan–Anseong cohort

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    Joshi P


    Full Text Available Pankaj Joshi,1,2 Woo Jin Kim,3,4 Sang-Ah Lee1–3 1Department of Preventive Medicine, 2BIT Medical Convergence Graduate Program, 3Department of Internal Medicine, 4Environmental Health Center, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do, South Korea Background: Dietary antioxidants have been suggested to have protective role against chronic obstructive pulmonary disease (COPD, but few prospective studies examined this relationship. The prospective study was conducted to evaluate the effect of dietary antioxidants on COPD risk and lung function in the Korean population.Methods: The data were collected from the community-based Korean Genome Epidemiology Study (KoGES cohort. To diagnose COPD, forced expiratory volume (FEV1 and forced vital capacity (FVC were measured by spirometry. The dietary intake of antioxidant vitamins was estimated from validated Food-Frequency Questionnaire. For the analysis, 325 COPD patients and 6,781 at risk subjects were selected from the cohort of 10,038 subjects. Multiple logistic regression models were used to examine the odds ratio (OR after adjusting for age, sex, marital status, income, history of asthma, history of tuberculosis, and smoking.Results: The risk of COPD was positively associated with aging, low education, low household income, lower body mass index, and cigarette smoking. The risk of COPD decreased with increase in the dietary vitamin C (ORQ1 vs Q5=0.66, Ptrend=0.03 and vitamin E (ORQ1 vs Q5=0.56, Ptrend=0.05 intake, predominantly, in men (Ptrend=0.01 and 0.05 for vitamins C and E, respectively. In addition, the lung function was significantly improved with increase in vitamins C (FEV1, P=0.04; FVC, P=0.03 and E (FEV1, P=0.03; FVC, P=0.04 intake. No statistically significant interactions were observed between smoking and vitamin C or E intake in relation to COPD risk among men.Conclusion: Our results suggest the independent beneficial effect of antioxidants, particularly

  15. Effect of Recruitment Methods on Response Rate in a Web-Based Study for Primary Care Physicians: Factorial Randomized Controlled Trial. (United States)

    So, Ryuhei; Shinohara, Kiyomi; Aoki, Takuya; Tsujimoto, Yasushi; Suganuma, Aya M; Furukawa, Toshi A


    Medical Information Network Clinical Trials Registry UMIN000025317; (Archived by WebCite at http://www.webcitation. org/6wOo1jl9t). ©Ryuhei So, Kiyomi Shinohara, Takuya Aoki, Yasushi Tsujimoto, Aya M Suganuma, Toshi A Furukawa. Originally published in the Journal of Medical Internet Research (, 08.02.2018.

  16. Highlights of Astronomy, Vol. 15 (United States)

    Corbett, Ian


    Preface; Part I. Gruber Cosmology Prize Lecture; Part II. Invited Discourses; Part III. Joint Discussions: 1. Dark matter in early-type galaxies Léon V. E. Koopmans and Tommaso Treu; 2. Diffuse light in galaxy clusters Magda Arnaboldi and Ortwin Gerhard; 3. Neutron stars - timing in extreme environments Tomaso Belloni, Mariano Méndez and Chengmin Zhang; 4. Progress in understanding the physics of Ap and related stars Margarida Cunha; 5. Modelling the Milky Way in the age of Gaia Annie C. Robin; 6. Time and astronomy Pascale Defraigne; 7. Astrophysical outflows and associated accretion phenomena Elisabete M. de Gouveia Dal Pino and Alex C. Raga; 8. Hot interstellar matter in elliptical galaxies Dong-Woo Kim and Silvia Pellegrini; 9. Are the fundamental constants varying with time? Paolo Molaro and Elisabeth Vangioni; 10. 3D views on cool stellar atmospheres - theory meets observation K. N. Nagendra, P. Bonifacio and H. G. Ludwig; 11. New advances in helio- and astero-seismology; 12. The first galaxies - theoretical predictions and observational clues; 13. Eta Carinae in the context of the most massive stars Theodore R. Gull and Augusto Damineli; 14. The ISM of galaxies in the far-infrared and sub-millimetre; 15. Magnetic fields in diffuse media Elisabete M. de Gouveia Dal Pino and Alex Lazarian; 16. IHY global campaign - whole heliosphere interval; Part IV. Special Sessions: SpS 1. IR and sub-mm spectroscopy - a new tool for studying stellar evolution Glenn Wahlgren, Hans Käufl and Florian Kerber; SpS 2. The international year of astronomy Pedro Russo, Catherine Cesarsky and Lars Lindberg Christensen; SpS 3. Astronomy in Antarctica in 2009 Michael G. Burton; SpS 4. Astronomy education between past and future J. P. De Greve; SpS 5. Accelerating the rate of astronomical discovery Ray P. Norris; SpS 6. Planetary systems as potential sites for life Régis Courtin, Alan Boss and Michel Mayor; SpS 7. Young stars, brown dwarfs, and protoplanetary disks Jane Gregorio

  17. Association between vitamin D receptor polymorphisms and osteoporosis in patients with COPD

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    Kim SW


    Full Text Available Sei Won Kim,1 Jong Min Lee,1 Jick Hwan Ha,1 Hyeon Hui Kang,1 Chin Kook Rhee,1 Jin Woo Kim,1 Hwa Sik Moon,1 Ki Hyun Baek,2 Sang Haak Lee1 1Division of Pulmonology, Critical Care and Sleep Medicine, 2Division of Endocrinology and Metabolism, Department of Internal Medicine, St Paul’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Background: Patients with COPD are at an increased risk of osteoporosis. Although many studies have addressed the relationship between the vitamin D receptor (VDR polymorphisms and bone health, this relationship has not been fully investigated in patients with COPD. In this study, we investigated the association of VDR polymorphisms with bone mineral density (BMD and other clinical parameters in patients with COPD. Patients and methods: In total, 200 patients with COPD were included in this study. The VDR polymorphisms rs1544410 (A/G-BsmI, rs7975232 (A/C-ApaI, rs731236 (C/T-TaqI, and rs10735810 (C/T-FokI were determined by Sanger sequencing using blood DNA samples. BMD of the lumbar vertebra and the femoral neck was measured by dual-energy X-ray absorptiometry. Other clinical parameters were also evaluated. Haplotype and multivariate analyses were also performed. Results: Sex, body mass index, steroid use, percentage of forced expiratory volume in 1 second (FEV1, alkaline phosphatase, and 25-hydroxyvitamin D significantly influenced the risk of osteoporosis. Patients with osteoporosis were more likely to carry the rs7975232 C allele compared to normal patients with BMD. Haplotypes GCT and GAT were related to osteoporosis. Patients without the haplotype GAT allele showed a significantly lower T-score at the femoral neck and an increased risk of osteoporosis (odds ratio [OR]= 2.78, 95% confidence interval [CI]= 1.20–6.48, P=0.018 compared with carriers in the dominant model. Conclusion: Genetic variations in VDR are significantly associated with osteoporosis among patients with COPD


    Directory of Open Access Journals (Sweden)

    K. V. Dobrego


    Full Text Available Various aerodynamic design elements and technics (wind deflectors, wind walls, etc. are utilized for improvement of the thermal efficiency of the natural draft cooling towers, particularly in conditions of cross wind. One of the technical methods, proposed by engineers of Belarus Academy of Sciences, is installation of the ventilation window in the center of the fill. This method is substantiated by the fact that the flow of cooling gas obtains maximum temperature and humidity near the center of the under-fill space of cooling tower and, as a consequence, performs minimal heat exchange. The influence of the fill ventilation window and wind deflectors in the inlet windows of the cooling tower on its thermal performance in condition of cross-wind is investigated in the paper numerically. The cooling tower of the “Woo-Jin” power plant (China 150 m of the height and 114 m of the base diameter was taken as a prototype. The analogy (equivalence between the heat and mass transfer was taken into consideration, which enabled us to consider single-phase flow and perform complicated 3D simulation by using modern personal computers. Heat transfer coefficient for the fill and its hydrodynamic resistance were defined by using actual data on total flow rate in the cooling tower. The numerical model and computational methods were tested and verified in numerous previous works. The non-linear dependence of the thermal performance of the cooling tower on wind velocity (with the minimum in vicinity of Ucr ~ 8 m/s for the simulated system was demonstrated. Calculations show that in the condition of the average wind speed the fill ventilation window doesn’t improve, but slightly decrease (by 3–7 % performance of the cooling tower. Situation changes in the condition of strong winds Ucw > 12 m/s, which are not typical for Belarus. Utilization of airflow deflectors at the inlet windows of cooling tower, conversely, increases thermal performance of the

  19. Proteinaceous Resin and Hydrophilic Encapsulation: A Self-Healing-Related Study (United States)

    Zheng, Ting

    .g. hydrophilic agent encapsulation, was addressed through the development of novel polyurethane-Poly(melamine-formaldehyde) (PU-PMF) dual-component capsules. Remarkably, the external PU insulation layer was fabricated through interfacial polymerization based on a water-in-oil-in-oil (W/O/O) emulsion template. Surface tension was identified as the main driving factor for the formation of the external oil phase. The internal PMF layer was observed to strongly influence the internal morphology of the capsule. A protocol was developed, and a typical capsule with dense and neat shell morphology with a shell/capsule diameter (around 3 %) was fabricated. This study provides solutions for the two aforementioned obstacles related to the development of the healing system for the protein-based materials.

  20. Presence of sarcopenia in asthma–COPD overlap syndrome may be a risk factor for decreased bone-mineral density, unlike asthma: Korean National Health and Nutrition Examination Survey (KNHANES IV and V (2008–2011

    Directory of Open Access Journals (Sweden)

    Lee DW


    Full Text Available Dong-Won Lee,1 Hyun-Jung Jin,2 Kyeong-Cheol Shin,2 Jin-Hong Chung,2 Hyoung-Woo Lee,3 Kwan-Ho Lee2 1Division of Pulmonology, Department of Internal Medicine, Andong Sungso Hospital, Andong, 2Division of Pulmonology and Allergy, 3Division of Endocrinology, Department of Internal Medicine, Yeungnam University Hospital, Daegu, South Korea Background: Sarcopenia and decreased bone-mineral density (BMD are common in elderly people, and are major comorbidities of obstructive airway disease (OAD. However, the relationship between sarcopenia and BMD in each OAD phenotype, especially asthma–COPD overlap syndrome (ACOS, is not yet clear. We aimed to evaluate differences in BMD according to the presence of sarcopenia in each OAD phenotype. Materials and methods: Among the research subjects in KNHANES IV and V (2008–2011, 5,562 were ≥50 years old and underwent qualified spirometry and dual-energy X-ray absorptiometry. A total of 947 subjects were included in the study: 89 had asthma, 748 COPD, and 110 ACOS. Results: In the COPD and ACOS phenotypes, T-scores were lower in the sarcopenia group than the nonsarcopenia group. Prevalence rates of osteopenia and osteoporosis were higher in the sarcopenia group than the nonsarcopenia group. (P<0.001 and P=0.017, respectively. The sarcopenia group had higher risks of developing osteopenia, osteoporosis, and low BMD than the nonsarcopenia group in the ACOS phenotype (OR 6.620, 95% CI 1.129–38.828 [P=0.036], OR 9.611, 95% CI 1.133–81.544 [P=0.038], and OR 6.935, 95% CI 1.194–40.272 [P=0.031], respectively. However, in the asthma phenotype, the sarcopenia group showed no increased risk compared with the nonsarcopenia group. Conclusion: In the ACOS phenotype, individuals with sarcopenia had a higher prevalence rate and higher risks of osteopenia and osteoporosis than those without sarcopenia among all OAD phenotypes. Keywords: asthma, chronic obstructive pulmonary disease, asthma–COPD overlap syndrome

  1. RETRACTED: The Mediating Effect of Social Capital on the Relationship Between Public Health Managers' Transformational Leadership and Public Health Nurses' Organizational Empowerment in Korea Public Health

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    Soo Young Jun, MPH, RN


    Full Text Available This article has been retracted: please see Elsevier Policy on Article Withdrawal ( Editor-in-Chief and ANR editorial board have decided to retract this article because the scientific integrity of the content cannot be guaranteed. The article shows evidence of redundant publication and falsification of instruments.This article was a duplicate of a paper that had already been published in Journal of the Korean Data & Information Science Society Vol 29, No. 3, May 2017. doi 10.7465/jkdi.2017.28.3.585 The identical data collection period, study sample, variables, and instruments between these two papers show strong evidence of plagiarism. One of the conditions of submission of a paper for publication is that authors declare explicitly that their work is original and has not appeared in a publication elsewhere. Re-use of any data should be appropriately cited.This article is published based on a master’s thesis (Kim YE. The effects of the transformational leadership of managers perceived by public health nurses and their social capital on empowerment [master’s thesis]. Dague (Korea: Kyungpook National University; 2016. p. 1-57. and the author of this dissertation is deleted. Inappropriate use of master’s thesis without appropriate disclosure and/or citation was made.The instruments [Multifactor leadership questionnaire (Kim DW. The relationship between transformational leadership and quality of nurses' care Service with nurses' organization citizenship behavior as a moderator. Health Soc Welf Rev. 2011;31(2:206e36. Korean, social capital (Han JW, Woo HY, Ju ES, Lim SH, Han SS. Effects of nurses' social capital on turnover intention: focused on the mediating effects organizational commitment and organizational cynicism. J Korean Acad Nurs. 2013;43(4:517e25. Korean, and Organizational empowerment (Oh EH, Chung BY. The effect of

  2. Analysis of Factors Controlling Cell Cycle that Can Be Synchronized Nondestructively During Root Cap Development

    Energy Technology Data Exchange (ETDEWEB)

    Hawes, Martha


    Publications and presentations during the final funding period, including progress in defining the substrate specificity, the primary goal of the project, are listed below. Both short-term and long-term responses mediated by PsUGT1 have been characterized in transgenic or mutant pea, alfalfa, and Arabidopsis with altered expression of PsUGT1. Additional progress includes evaluation of the relationship between control of the cell cycle by PsUGT1 and other glycosyltransferase and glycosidase enzymes that are co-regulated in the legume root cap during the onset of mitosis and differentiation. Transcriptional profiling and multidimensional protein identification technology ('MudPIT') have been used to establish the broader molecular context for the mechanism by which PsUGT1 controls cell cycle in response to environmental signals. A collaborative study with the Norwegian Forest Research Institute (who provided $10,000.00 in supplies and travel funds for collaborator Dr. Toril Eldhuset to travel to Arizona and Dr. H. H. Woo to travel to Norway) made it possible to establish that the inducible root cap system for studying carbohydrate synthesis and solubilization is expressed in gymnosperm as well as angiosperm species. This discovery provides an important tool to amplify the potential applications of the research in defining conserved cell cycle machinery across a very broad range of plant species and habitats. The final work, published during 2009, revealed an additional surprising parallel with mammalian immune responses: The cells whose production is controlled by PsUGT1 appear to function in a manner which is analogous to that of white blood cells, by trapping and killing in an extracellular manner. This may explain why mutation within the coding region of PsUGT1 and its homolog in humans (UGT1) is lethal to plants and animals. The work has been the subject of invited reviews. A postdoctoral fellow, eight undergraduate students, four M.S. students and

  3. Nuclear employers meeting their employees' motives

    International Nuclear Information System (INIS)

    Heininen-Ojanperae, Marke


    Full text: In modem Western societies the employees' motivational issues are no more only their employers' concern. The pioneering, older generations in the nuclear field may share a sense of common depression. The 'emulator' generation with to 15 years of work experience may find they cannot see clear or similar career paths due to construction recession. Their skills may be harnessed in future decommissioning, only. Finally, the young people entering professional education with these signs around may opt for other competing trades already during their first years in college and university, although their capacity would be crucial in case of any new wave arising. However, nuclear generation is a trade as any, even the safety concern can be seen as a facet of quality of the nuclear companies' service, which can be drawn in any situation from the customers or stake holders. All businesses have life-cycles and only a few of us can ride the rising wave - the majority of us are either lagging behind or too early. This is not to deny the general responsibility of those wooing new people to the trade or having made earlier decisions. The motivational solution, if any, is to be found in celebrating the richness of the individual and local working situations. With this idea in mind, we may summarise a set of constructive approaches for motivation: - The complexity of the work and technical condition at nuclear plants; - Certain exclusiveness of the work; - Heritage of good working conditions and quality philosophy; - Large risks that can actually be managed at everyday work; - Certain general environmental benefits; - Heritage of global aspects in networking; - The promise and new learning of new user-countries; - Scientific emphasis; - Waning Big Science approach; - Many nuclear plants are situated in impressive settings of nature. Finally, there is also a set of de-constructive, motivational factors: - The quest of high, total availability as basic load power excludes a

  4. Biological age as a health index for mortality and major age-related disease incidence in Koreans: National Health Insurance Service – Health screening 11-year follow-up study

    Directory of Open Access Journals (Sweden)

    Kang YG


    Full Text Available Young Gon Kang,1 Eunkyung Suh,2 Jae-woo Lee,3 Dong Wook Kim,4 Kyung Hee Cho,5 Chul-Young Bae1 1Department of R&D, MediAge Research Center, Seongnam, Republic of South Korea; 2Department of Family Medicine, College of Medicine, CHA University, Chaum, Seoul, Republic of South Korea; 3Department of Family Medicine, College of Medicine, Chungbuk National University, Cheongju, Republic of South Korea; 4Department of Policy Research Affairs, National Health Insurance Service Ilsan Hospital, Goyang, Republic of South Korea; 5Department of Family Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Republic of South KoreaPurpose: A comprehensive health index is needed to measure an individual’s overall health and aging status and predict the risk of death and age-related disease incidence, and evaluate the effect of a health management program. The purpose of this study is to demonstrate the validity of estimated biological age (BA in relation to all-cause mortality and age-related disease incidence based on National Sample Cohort database.Patients and methods: This study was based on National Sample Cohort database of the National Health Insurance Service – Eligibility database and the National Health Insurance Service – Medical and Health Examination database of the year 2002 through 2013. BA model was developed based on the National Health Insurance Service – National Sample Cohort (NHIS – NSC database and Cox proportional hazard analysis was done for mortality and major age-related disease incidence.Results: For every 1 year increase of the calculated BA and chronological age difference, the hazard ratio for mortality significantly increased by 1.6% (1.5% in men and 2.0% in women and also for hypertension, diabetes mellitus, heart disease, stroke, and cancer incidence by 2.5%, 4.2%, 1.3%, 1.6%, and 0.4%, respectively (p<0.001.Conclusion: Estimated BA by the developed BA model based on NHIS – NSC database is expected to be

  5. More efficient evolutionary strategies for model calibration with watershed model for demonstration (United States)

    Baggett, J. S.; Skahill, B. E.


    distribution algorithms. pp. 75-102, Springer Kern, S., N. Hansen and P. Koumoutsakos (2006). Local Meta-Models for Optimization Using Evolution Strategies. In Ninth International Conference on Parallel Problem Solving from Nature PPSN IX, Proceedings, pp.939-948, Berlin: Springer. Tahk, M., Woo, H., and Park. M, (2007). A hybrid optimization of evolutionary and gradient search. Engineering Optimization, (39), 87-104.

  6. Risk factors for chronic obstructive pulmonary disease among never-smokers in Korea

    Directory of Open Access Journals (Sweden)

    Lee SJ


    Full Text Available Seok Jeong Lee,1 Seo Woo Kim,1 Kyoung Ae Kong,2 Yon Ju Ryu,1 Jin Hwa Lee,1 Jung Hyun Chang1 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, 2Department of Clinical Trial Center, School of Medicine, Ewha Womans University, Seoul, Republic of Korea Background: Chronic obstructive pulmonary disease (COPD patients include those who have never smoked. However, risk factors other than smoking in never-smokers have not been elucidated sufficiently. This study investigated the risk factors for COPD among never-smokers in Korea using population-based data. Methods: The data were retrieved from the Korean National Health and Nutrition Survey IV conducted from 2007 to 2009. Among subjects aged 40 years or older who underwent appropriate pulmonary function tests, never-smokers not diagnosed with asthma and not showing a restrictive pattern on pulmonary function tests were enrolled. Risk factors of COPD in never-smokers were analyzed using logistic regression models. Results: Among 24,871 participants in the representative Korean cohort, 3,473 never-smokers were enrolled. COPD patients accounted for 7.6% of the never-smokers. In the logistic regression analysis, low education status (odds ratio [OR]: 2.0; 95% confidence interval [CI]: 1.2–3.2, occupational exposure (OR: 2.6; 95% CI: 1.3–5.3, a history of tuberculosis (OR: 4.5; 95% CI: 2.3–8.7, bronchiectasis (OR: 6.0; 95% CI: 1.4–25.4, male sex (OR: 4.2; 95% CI: 2.6–6.7, advanced age (60–69 years vs 40–49 years; OR: 3.8; 95% CI: 2.0–7.0, and being underweight (body mass index <18.5 vs 18.0–24.9 kg/m2; OR: 3.1; 95% CI: 1.0–9.4 were associated with the development of COPD. Conclusion: Low education status, manual labor, a history of tuberculosis and bronchiectasis, as well as male sex, advanced age and being underweight were risk factors for COPD in Korean never-smokers. Keywords: socioeconomic status, chronic obstructive pulmonary disease, never-smoker

  7. Testing geopressured geothermal reservoirs in existing wells: Detailed completion prognosis for geopressured-geothermal well of opportunity, prospect #7

    Energy Technology Data Exchange (ETDEWEB)

    Godchaux, Frank A.


    This book is a detailed prognosis covering the acquisition, completion, drilling, testing and abandonment of the Frank A. Godchaux, III, Well No. 1 under the Wells of Opportunity Program. The well is located approximately 12 miles southeast of the city of Abbeville, Louisiana. Eaton Operating Company proposes to test a section of the Planulina sand at a depth ranging from 15,584 to 15,692 feet. The reservoir pressure is estimated to be 14,480 psi and the temperature of the formation water is expected to be 298 F. The water salinity is calculated to be 75,000 ppm. The well is expected to produce 20,000 barrels of water per day with a gas content of 44 standard cubic feet pre barrel. The well was acquired from C and K Petroleu, Inc. on March 20, 1981. C and K abandoned the well at a total depth of 16,000 feet. The well has a 7-5/8 inches liner set at 13,387 feet. Eaton proposes to set 5-1/2 inch casing at 16,000 feet and produce the well through the casing using a 2-3/8 inch tubing string for wireline protection and for pressure control. A 4,600 foot saltwater disposal well will be drilled on the site and testing will be conducted similar to previous Eaton tests. The total estimated cost to perform the work is $2,959,000. An optional test from 14,905 to 15,006 feet may be performed after the original test and will require a workover with a rig on location to perform the plugback. The surface production equipment utilized on previous Eaton WOO tests will be utilized on this test. This equipment has worked satisfactorily and all parties involved in the testing are familiar with its operation. The Institute of Gas Technology and Mr. Don Clark will handle the sampling and testing and reservoir evaluation, respectively, as on the previous Eaton tests.

  8. Effectiveness of professional oral health care intervention on the oral health of residents with dementia in residential aged care facilities: a systematic review protocol. (United States)

    Yi Mohammadi, Joanna Jin; Franks, Kay; Hines, Sonia


    aged care facilities, with the model of care involving dental hygienists/oral health therapists having merit.The concept of professional oral care involves an oral health professional such as a dental hygienist or oral health therapist supervising or assisting residents with their oral care. Oral care involves the mechanical removal of plaque and food debris using a toothbrush, interproximal brush and floss.In 2014, Morino et al. explored the efficacy of short term professional oral care from dental hygienists once a week after breakfast for one month. In this study, the dental hygienists did not perform dental scaling but brushed subjects' teeth using a toothbrush and interdental brush. Dental plaque scores decreased significantly (Fisher's two-tailed tests, peffects of this short term intervention were sustained for the following three months (Wilcoxon test, pfacility using the Oral Health Assessment Tool (OHAT) and Geriatric Oral Health Assessment Index (GOHAI) scores to measure oral health. The results from this study showed improvements in three measured areas (tongue health, denture status and oral cleanliness) in the dental hygiene champion group. These findings suggest that the presence of a dental hygiene champion in long term care facilities may positively impact the oral health of residents requiring assistance with their oral care. However, the authors noted further research in this concept is required.Van Der Putten GJ et al. explored the effectiveness of a supervised implementation of an oral health care guideline in care homes. In each ward of the care homes, a nurse who acted as the ward oral health care organiser (WOO) was appointed. The dental hygienist and an investigator would attend the RACFs every six weeks to support them. The dental hygienist would train the WOO, and the WOO would train the ward nurses and nurse assistants. Participants were allocated into an intervention or a control group. The intervention group received supervised oral care

  9. Characteristics of stable chronic obstructive pulmonary disease patients in the pulmonology clinics of seven Asian cities

    Directory of Open Access Journals (Sweden)

    Oh YM


    Full Text Available Yeon-Mok Oh,1 Arvind B Bhome,2 Watchara Boonsawat,3 Kirthi Dias Gunasekera,4 Dushantha Madegedara,5 Luisito Idolor,6 Camilo Roa,6 Woo Jin Kim,7 Han-Pin Kuo,8 Chun-Hua Wang,8 Le Thi Tuyet Lan,9 Li-Cher Loh,10 Choo-Khoon Ong,10 Alan Ng,11 Masaharu Nishimura,12 Hironi Makita,12 Edwin K Silverman,13 Jae Seung Lee,1 Ting Yang,14 Yingxiang Lin,14 Chen Wang,14 Sang-Do Lee1  1Department of Pulmonary and Critical Care Medicine and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; 2Department of Pulmonary and Critical Care, "Friends of the Breathless" Foundation, Pune, India; 3Department of Medicine, Khon Kaen University, Khon Kaen, Thailand; 4Central Chest Clinic, Colombo and National Hospital of Sri Lanka; 5Respiratory Disease Treatment Unit and Teaching Hospital Kandy, Sri Lanka; 6Section of Respiratory Services and Physical Therapy and Rehabilitation Lung Center of the Philippines, Quezon City, Philippines; 7Department of Internal Medicine, Kangwon National University, Kang Won, Korea; 8Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan; 9Respiratory Care Center, University Medical Center Ho Chi Minh City, Vietnam; 10Department of Medicine, Penang Medical College, Penang, Malaysia; 11Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore; 12Division of Respiratory Medicine, Department of Internal Medicine, Hokkaido University Hospital, Sapporo, Japan; 13Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; 14Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaAll authors made an equal contribution to this studyBackground and objectives: Chronic obstructive pulmonary disease (COPD is responsible for significant morbidity and mortality worldwide. We evaluated the characteristics of stable COPD patients in

  10. SOHO-Ulysses Coordinated Studies During the Two Extended Quadratures and the Alignment of 2007-2008 (United States)

    Suess, S. T.; Poletto, G.


    us to study the variation of element abundances across streamer borders in the corona and,correspondingly, "in situ". Also, observing plasma over prolonged time intervals and at different latitudes, we may examine the latitude variation of the fractionation effect (e.g. Yon Steiger, 2002) and its dependence on time (e.g. Woo, 2004). For instance, if the FIP bias is dictated by the duration of plasma confinement in solar loops, its value in streamers should depend on the streamer age. Analogous variations should be found in the abundances of "in situ" plasma released by the streamer. All Ulysses and SOHO data is in the public domain and accessible so different objectives could be addressed by others. The winter 2008 quadrature will be well into the next sunspot cycle and there might be significant high mid-latitude activity. Ulysses will be up to 80 degrees in the northern hemisphere at this time and able to detect the resulting ICMEs and ejecta, allowing us to study the physical parameters of the propagating CME bubble/core/front, and/or to study the coronal and "in situ" characteristics of the current sheet associated with the event (e.g. Bemporad et al. 2005), so far still vaguely defined.

  11. Comparison of tadalafil pharmacokinetics after administration of a new orodispersible film versus a film-coated tablet

    Directory of Open Access Journals (Sweden)

    Park SI


    Full Text Available Sang-In Park,1,* Su-Hak Heo,2,3,* Gihwan Kim,2 Seokhoon Chang,2 Keon-Hyoung Song,3 Min-Gul Kim,4 Eun-Heui Jin,5 JaeWoo Kim,5 SeungHwan Lee,1 Jang Hee Hong5,6 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea; 2R&D Center, C.L. Pharm Co., Ltd, Seoul, Republic of Korea; 3Department of Pharmaceutical Engineering, College of Medical Science, Soonchunhyang University, Asan, Republic of Korea; 4Department of Pharmacology, School of Medicine, Chonbuk National University, Jeonju, Republic of Korea; 5Clinical Trials Center, Chungnam National University Hospital, Daejeon, Republic of Korea; 6Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea *These authors contributed equally to this work Background: An orodispersible film (ODF of tadalafil may provide increased convenience for erectile dysfunction (ED patients as compared to conventional tablet formulations. In this study, we aimed to compare the pharmacokinetic, safety, and tolerability profiles of a newly developed ODF formulation of tadalafil to those of a film-coated tablet (FCT of tadalafil.Materials and methods: This study was conducted in healthy male subjects using an open-label, randomized sequence, two-period, two-formulation, single-dose, crossover design. The subjects were randomly assigned to one of two sequences of the two formulations: both the test drug (ODF and the reference drug (FCT contained 20 mg of tadalafil. Blood samples were collected up to 72 h after administration. Plasma concentrations of tadalafil were analyzed using liquid chromatography–tandem mass spectrometry. Geometric mean ratios (GMRs of the ODF to FCT formulations and their 90% CIs for the pharmacokinetic parameters were estimated. Safety and tolerability were assessed throughout the study.Results: Forty healthy male subjects were enrolled, and 36 of these completed the

  12. A 90-day study of sub-chronic oral toxicity of 20 nm positively charged zinc oxide nanoparticles in Sprague Dawley rats

    Directory of Open Access Journals (Sweden)

    Park HS


    Full Text Available Hark-Soo Park,1 Seon-Ju Kim,1 Taek-Jin Lee,1 Geon-Yong Kim,1 EunHo Meang,1 Jeong-Sup Hong,1 Su-Hyon Kim,1 Sang-Bum Koh,1 Seung-Guk Hong,1 Yle-Shik Sun,1 Jin Seok Kang,2 Yu-Ri Kim,3 Meyoung-Kon Kim,3 Jayoung Jeong,4 Jong-Kwon Lee,4 Woo-Chan Son,5 Jae-Hak Park61General Toxicology Team, Korea Testing and Research Institute, Seoul, 2Department of Biomedical Laboratory Science, Namseoul University, Cheonan, 3Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, 4National Institute of Food and Drug Safety Evaluation, Seoul, 5Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, 6Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, KoreaPurpose: The study reported here was conducted to determine the systemic oral toxicity and to find the no-observed-adverse-effect level of 20 nm positively charged zinc oxide (ZnOSM,20(+ nanoparticles in Sprague Dawley rats for 90 days.Methods: For the 90-day toxicity study, the high dose was set as 500 mg per kg of body weight (mg/kg and the middle and low dose were set to 250 mg/kg and 125 mg/kg, respectively. The rats were held for a 14-day recovery period after the last administration, to observe for the persistence or reduction of any toxic effects. A distributional study was also carried out for the systemic distribution of ZnOSM,20(+ NPs.Results: No rats died during the test period. There were no significant clinical changes due to the test article during the experimental period in functional assessment, body weight, food and water consumption, ophthalmological testing, urine analysis, necropsy findings, or organ weights, but salivation was observed immediately after administration in both sexes. The total red blood cell count was increased, and hematocrit, albumin, mean cell volume, mean cell hemoglobin, and mean cell hemoglobin concentration were decreased significantly compared with

  13. Predicting treatable traits for long-acting bronchodilators in patients with stable COPD

    Directory of Open Access Journals (Sweden)

    Kang J


    Full Text Available Jieun Kang,1,* Ki Tae Kim,2,* Ji-Hyun Lee,3 Eun Kyung Kim,3 Tae-Hyung Kim,4 Kwang Ha Yoo,5 Jae Seung Lee,1 Woo Jin Kim,6 Ju Han Kim,2 Yeon-Mok Oh1 1Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 2Seoul National University Biomedical Informatics and Systems Biomedical Informatics Research Center, Division of Biomedical Informatics, Seoul National University College of Medicine, Seoul, 3Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, 4Division of Pulmonology, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, 5Department of Internal Medicine, Konkuk University Hospital, Konkuk University School of Medicine, Seoul, 6Department of Internal Medicine and Environmental Health Center, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea *These authors contributed equally to this work Purpose: There is currently no measure to predict a treatability of long-acting β-2 agonist (LABA or long-acting muscarinic antagonist (LAMA in patients with chronic obstructive pulmonary disease (COPD. We aimed to build prediction models for the treatment response to these bronchodilators, in order to determine the most responsive medication for patients with COPD.Methods: We performed a prospective open-label crossover study, in which each long-acting bronchodilator was given in a random order to 65 patients with stable COPD for 4 weeks, with a 4-week washout period in between. We analyzed 14 baseline clinical traits, expression profiles of 31,426 gene transcripts, and damaged-gene scores of 6,464 genes acquired from leukocytes. The gene expression profiles were measured by RNA microarray and the damaged-gene scores were obtained after DNA exome sequencing. Linear regression analyses were performed to build prediction models after using

  14. Pharmacokinetic and bioequivalence study of a telmisartan/S-amlodipine fixed-dose combination (CKD-828 formulation and coadministered telmisartan and S-amlodipine in healthy subjects

    Directory of Open Access Journals (Sweden)

    Kang WY


    Full Text Available Woo Youl Kang,1,2,* Sook Jin Seong,1,* Boram Ohk,1,2 Mi-Ri Gwon,1,3 Bo Kyung Kim,1,2 Sookie La,4 Hyun-Ju Kim,3 Seungil Cho,1 Young-Ran Yoon,1,2 Dong Heon Yang,5 Hae Won Lee1 1Clinical Trial Center, Kyungpook National University Hospital, Daegu, Republic of Korea; 2Department of Biomedical Science, BK21 Plus KNU Bio-Medical Convergence Program for Creative Talent, Kyungpook National University Graduate School, Daegu, Republic of Korea; 3Department of Molecular Medicine, Cell and Matrix Research Institute, Kyungpook National University School of Medicine, Daegu, Republic of Korea; 4Analytical Research Division, Biocore Co Ltd, Seoul, Republic of Korea; 5Division of Cardiology, Department of Internal Medicine, Kyungpook National University School of Medicine & Hospital, Daegu, Republic of Korea *These authors contributed equally to this work Purpose: A new fixed-dose combination (FDC formulation of telmisartan 80 mg and S-amlodipine 5 mg (CKD-828 has been developed to increase convenience (as only one tablet is required per day and improve treatment compliance.Methods: The pharmacokinetic characteristics and tolerability of an FDC of telmisartan and S-amlodipine were compared to those after coadministration of the individual agents in this randomized, open-label, single-dose, two-way, four-period, crossover study. To analyze the telmisartan and S-amlodipine plasma concentrations using a validated liquid chromatography–tandem mass spectrometry method, serial blood samples were collected up to 48 hours post-dose for telmisartan and 144 hours post-dose for S-amlodipine, in each period.Results: Forty-eight healthy subjects were enrolled, and 43 completed the study. The mean peak plasma concentration (Cmax and the area under the plasma concentration–time curve from time 0 to the last measurement (AUC0–t values of telmisartan were 522.29 ng/mL and 2,475.16 ng⋅h/mL for the FDC, and 540.45 ng/mL and 2,559.57 ng⋅h/mL for the individual agents

  15. Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells

    Directory of Open Access Journals (Sweden)

    Kim YW


    Full Text Available Yong-Wan Kim,1 Eun Young Kim,1 Doin Jeon,1 Juinn-Lin Liu,2 Helena Suhyun Kim,3 Jin Woo Choi,4 Woong Shick Ahn5 1Cancer Research Institute of Medical Science, The Catholic University of Korea, Seoul, Republic of Korea; 2Brain Tumor Center, Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, TX, USA; 3Cancer Rehab Laboratory, RH Healthcare Systems Inc, TX, USA; 4Harvard Medical School and Wellman Center for Photomedicine, Cambridge, MA, USA; 5Department of Obstetrics and Gynecology, The Catholic University of Korea, Seoul, Republic of Korea Abstract: Paclitaxel (Taxol resistance remains a major obstacle for the successful treatment of ovarian cancer. MicroRNAs (miRNAs have oncogenic and tumor suppressor activity and are associated with poor prognosis phenotypes. miRNA screenings for this drug resistance are needed to estimate the prognosis of the disease and find better drug targets. miRNAs that were differentially expressed in Taxol-resistant ovarian cancer cells, compared with Taxol-sensitive cells, were screened by Illumina Human MicroRNA Expression BeadChips. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR was used to identify target genes of selected miRNAs. Kaplan–Meier survival analysis was applied to identify dysregulated miRNAs in ovarian cancer patients using data from The Cancer Genome Atlas. A total of 82 miRNAs were identified in ovarian carcinoma cells compared to normal ovarian cells. miR-141, miR-106a, miR-200c, miR-96, and miR-378 were overexpressed, and miR-411, miR-432, miR-494, miR-409-3p, and miR-655 were underexpressed in ovarian cancer cells. Seventeen miRNAs were overexpressed in Taxol-resistant cells, including miR-663, miR-622, and HS_188. Underexpressed miRNAs in Taxol-sensitive cells included miR-497, miR-187, miR-195, and miR-107. We further showed miR-663 and miR-622 as significant prognosis markers of the chemo-resistant patient group. In particular, the

  16. Investigation and analysis of oncologists' knowledge of morphine usage in cancer pain treatment

    Directory of Open Access Journals (Sweden)

    Liu W


    Full Text Available Weiran Liu,1,* Shumin Xie,2,* Lin Yue,3,* Jiahao Liu,2 Stephanie Mu-Lian Woo,4 Weilin Liu,2 Adam R Miller,5 Jing Zhang,6 Lijun Huang,7 Lei Zhang8,*1Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Anesthesia, Tianjin, People's Republic of China; 2The Xiangya Medical School of Central-South University, Changsha, People's Republic of China; 3Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Outpatient Service, Tianjin, People's Republic of China; 4Harvard University, Cambridge, MA, USA; 5Indiana University School of Medicine, Indianapolis, IN, USA; 6Tianjin Medical University, Tianjin, People's Republic of China; 7Hunan Provincial Tumor Hospital, Department of Lymphoma and Hematology, Changsha, People's Republic of China; 8Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Lung Cancer Center, Department of Thoracic Surgery, Tianjin, People's Republic of China *These authors contributed equally to this paperPurpose: To examine oncologists' knowledge of cancer pain and morphine's clinical application in the People's Republic of China. In addition, this study analyzes and discusses the negative factors that currently affect the clinical application of morphine.Patients and methods: A questionnaire survey was given to a random sample of 150 oncologists from Tianjin Medical University Cancer Institute and Hospital. The statistical results were analyzed and processed using SPSS version 21.0 and Matlab version 2012a statistical software. Single-factor analysis of variance, Kruskal–Wallis nonparametric test, and independent samples t-test were adopted to analyze the difference in knowledge scores of morphine usage. The study

  17. Korean Medication Algorithm Project for Bipolar Disorder: third revision

    Directory of Open Access Journals (Sweden)

    Woo YS


    Full Text Available Young Sup Woo,1 Jung Goo Lee,2,3 Jong-Hyun Jeong,1 Moon-Doo Kim,4 Inki Sohn,5 Se-Hoon Shim,6 Duk-In Jon,7 Jeong Seok Seo,8 Young-Chul Shin,9 Kyung Joon Min,10 Bo-Hyun Yoon,11 Won-Myong Bahk1 1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, South Korea; 2Department of Psychiatry, Inje University Haeundae Paik Hospital, Busan, South Korea;3Paik Institute for Clinical Research, Inje Univeristy, Busan, South Korea; 4Department of Psychiatry, Jeju National University Hospital, Jeju, South Korea; 5Department of Psychiatry, Keyo Hospital, Keyo Medical Foundation, Uiwang, South Korea; 6Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Soonchunhyang University, Cheonan, South Korea; 7Department of Psychiatry, Sacred Heart Hospital, Hallym University, Anyang, South Korea; 8Department of Psychiatry, School of Medicine, Konkuk University, Chungju, South Korea; 9Department of Psychiatry, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, South Korea; 10Department of Psychiatry, College of Medicine, Chung-Ang University, Seoul, South Korea; 11Department of Psychiatry, Naju National Hospital, Naju, South Korea Objective: To constitute the third revision of the guidelines for the treatment of bipolar disorder issued by the Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP 2014. Methods: A 56-item questionnaire was used to obtain the consensus of experts regarding pharmacological treatment strategies for the various phases of bipolar disorder and for special populations. The review committee included 110 Korean psychiatrists and 38 experts for child and adolescent psychiatry. Of the committee members, 64 general psychiatrists and 23 child and adolescent psychiatrists responded to the survey. Results: The treatment of choice (TOC for euphoric, mixed, and psychotic mania was the combination of a mood stabilizer (MS and an atypical antipsychotic (AAP; the TOC for

  18. Biological test methods for the ecotoxicological characterization of wastes. Final report; Biologische Testerverfahren zur oekotoxikologischen Charakterisierung von Abfaellen. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Becker, Roland [Bundesanstalt fuer Materialforschung, Berlin (Germany); Donnevert, Gerhild [Fachhochschule Giessen-Friedberg (Germany). FB MNI; Roembke, Joerg [ECT Oekotoxikologie GmbH, Floersheim am Main (Germany)


    battery the acceptance rate varied between 74.1% (Algae test) and 92.6% (Daphnia test). Methodologically, no problems occurred but further guidance on moisture determination in the terrestrial tests as well as details concerning reference testing and data evaluation for several tests are needed. Independently which test system is considered, SOI always caused the lowest effects and WOO was most toxic, while the EC50 values of INC show an intermediate toxicity. Among the aquatic tests, daphnids and one algal species were the most sensitive ones, while plants were always more sensitive than earthworms in the solid waste samples. Based on the test results from additional tests proposals for the modification of the existing basic test battery could be made. For example, the earthworm acute test could be replaced by another soil invertebrate test with higher sensitivity. Further work performed in parallel to the ring test improves waste testing considerably (e.g. the use of artificial soil as control substrate). A comparison of the ring test results with literature data published so far revealed a good agreement. The results of this ring test support confirm that a combination of a battery of biological tests and chemical residue analysis is needed for an ecotoxicological characterization of wastes. With small modifications proposed in this report the basic test battery is considered to be well suitable for the hazard and risk assessment of wastes. Further, probably multi-variate evaluation of the ring test results will improve the identification of those tests most qualified for the ecotoxicological characterization of wastes. Finally, the experiences made in the ring test support also the proposals made in CEN guideline 14735 (2005) concerning the performance of such tests. (orig.)

  19. Volcanic risk metrics at Mt Ruapehu, New Zealand: some background to a probabilistic eruption forecasting scheme and a cost/benefit analysis at an open conduit volcano (United States)

    Jolly, Gill; Sandri, Laura; Lindsay, Jan; Scott, Brad; Sherburn, Steve; Jolly, Art; Fournier, Nico; Keys, Harry; Marzocchi, Warner


    setting up BET_EF for Mt Ruapehu we are forced to define quantitatively what the background activity is. This will result in a quantitative evaluation of what changes in long time monitored parameters may influence the probability of future eruptions. The slopes of Mt Ruapehu host the largest ski area in North Island, New Zealand. Lahars have been generated as a result of several eruptions in the last 50 years, and some of these have reached the ski runs in a very short time frame (around 90 seconds from the beginning of the eruption). In the light of these potentially hazardous lahars, we use the output probabilities provided by BET_EF in a practical and rational decision scheme recently proposed by Marzocchi and Woo (2009) based on a cost/benefit analysis (CBA). In such scheme, a C/L ratio is computed, based on the costs (C) of practical mitigation actions to reduce risk (e.g., a public warning scheme and other means of raising awareness, and a call for a temporary and/or partial closure of the ski area) and on the potential loss (L) if no mitigation action is taken and an eruption occurs causing lahars down the ski fields. By comparing the probability of eruption-driven lahars and the C/L ratio, it is possible to define the most rational mitigation actions that can be taken to reduce the risk to skiers, snowboarders and staff on skifield. As BET_EF probability of eruption changes dynamically as updated monitoring data are received, the authorities can decide, at any specific point in time, what is the best action according to the current monitoring of the volcano. In this respect, CBA represents a bridge linking scientific output (probabilities) and Decision Makers (practical mitigation actions).

  20. The NDH diplomacy

    Directory of Open Access Journals (Sweden)

    Trifković Srđa


    Full Text Available The Belgrade coup of 27 March 1941 forced Hitler to improvize the post-Yugoslav political arrangements, as in the preceding years he had sought to woo, rather than destroy, the Kingdom. For his part, just before the Axis attack Mussolini reactivated the leader of ustaša émigrés Ante Pavelić and obtained his reaffirmation of earlier commitments to cede Dalmatia to Italy. Hitler accepted the ustaša 'solution,' whereby his strategy was to let the Italians make enemies of Croats by annexationist policy, and at the same time to encourage Pavelić to terrorize the Serbs. His stratagem resulted in the chronic weakness of the occupation system. Italy did not secure longterm control over the Independent State of Croatia (NDH. Latent antra-Axis tensions provided Pavelić with the room to maneuver between Rome and Berlin and to secure a degree of autonomous action for himself - primarily in his radical attempt to solve the 'Serb question' and in the economic sphere. The NDH diplomatic apparatus reflected the ustaša power structure and the character of the state. Reports from missions abroad were sent mostly ad hoc and they were devoid of attempts to draw analytical conclusions from the news. They were invariably imbued with ungrounded optimism until the very end, likely because of the reluctance to present inferences which the political leaders would not be pleased to hear. Available archives do not indicate how the decisions affecting the NDH foreign relations were formulated; they were probably made by Pavelić and verbally conveyed to the minister. The areas of activity of the foreign ministry were twofold: consular work and the maintenance of routine relations with the Axis powers and their satellites. The consulates in the Reich were mainly dealing with the workers from the NDH in Germany, and they were actively discriminating against the Serbs who were issued one-way travel passes which prevented their return to Germany. After the fall of Italy

  1. A new inventory for two-wheel vehicle emissions in West Africa for 2002 (United States)

    Assamoi, Eric-Michel; Liousse, Catherine


    Rather surprisingly, urban atmospheric particulate levels in West Africa compare with measured concentrations in Europe and Asia megacities (Liousse, C., Galy-Lacaux, C., Assamoi, E.-M., Ndiaye, A., Diop, B., Cachier, H., Doumbia, T., Gueye, P., Yoboue, V., Lacaux, J.-P., Guinot, B., Guillaume, B., Rosset, R., Castera, P., Gardrat, E., Zouiten, C., Jambert, C., Diouf, A., Koita, O., Baeza, A., Annesi-Maesano, I., Didier, A., Audry, S., Konare, A., 2009. Integrated Focus on West African Cities (Cotonou, Bamako, Dakar, Ouagadougou, Abidjan, Niamey): Emissions, Air Quality and Health Impacts of Gases and Aerosols. Third International AMMA Conference on Predictability of the West African Moosoon Weather, Climate and Impacts. Ouagadougou, Burkina Faso. July 20-24). This pollution mainly derives from road traffic emissions with, in some capitals (e.g. Cotonou), the strong contribution of two-wheel vehicles. Two key questions arise: are presently available emission inventories (e.g. Junker, C., Liousse, C., 2008. A global emission inventory of carbonaceous aerosol from historic records of fossil fuel and biofuel consumption for the period 1860-1997. Atmospheric Chemistry Physics, 8, 1-13; Bond, T.C., Streets, D.G., Yarber, K.F., Nelson, S.M., Woo, J.H., Klimont, Z., 2004. A technology-based global inventory of black and organic carbon emissions from combustion. Journal of Geophysical Research, 1009, D14203, DOI:10.1029/2003JD003697) able to account for these emissions? And, if not, how can we remedy this? The aim of this paper is to develop a methodology to estimate emissions produced by two-wheel vehicles in West Africa for 2002 in a context where reliable information is hardly available. Fuel consumption ratios between two-wheel engines (in this work) and all vehicles issued from UN database ( are as high as 169%, 264% and 628%, for Burkina Faso, Mali and Chad respectively, indicating that this global

  2. Combining probabilistic hazard assessment with cost-benefit analysis to support decision making in a volcanic crisis from the Auckland Volcanic Field, New Zealand (United States)

    Sandri, Laura; Jolly, Gill; Lindsay, Jan; Howe, Tracy; Marzocchi, Warner


    One of the main challenges of modern volcanology is to provide the public with robust and useful information for decision-making in land-use planning and in emergency management. From the scientific point of view, this translates into reliable and quantitative long- and short-term volcanic hazard assessment and eruption forecasting. Because of the complexity in characterizing volcanic events, and of the natural variability of volcanic processes, a probabilistic approach is more suitable than deterministic modeling. In recent years, two probabilistic codes have been developed for quantitative short- and long-term eruption forecasting (BET_EF) and volcanic hazard assessment (BET_VH). Both of them are based on a Bayesian Event Tree, in which volcanic events are seen as a chain of logical steps of increasing detail. At each node of the tree, the probability is computed by taking into account different sources of information, such as geological and volcanological models, past occurrences, expert opinion and numerical modeling of volcanic phenomena. Since it is a Bayesian tool, the output probability is not a single number, but a probability distribution accounting for aleatory and epistemic uncertainty. In this study, we apply BET_VH in order to quantify the long-term volcanic hazard due to base surge invasion in the region around Auckland, New Zealand's most populous city. Here, small basaltic eruptions from monogenetic cones pose a considerable risk to the city in case of phreatomagmatic activity: evidence for base surges are not uncommon in deposits from past events. Currently, we are particularly focussing on the scenario simulated during Exercise Ruaumoko, a national disaster exercise based on the build-up to an eruption in the Auckland Volcanic Field. Based on recent papers by Marzocchi and Woo, we suggest a possible quantitative strategy to link probabilistic scientific output and Boolean decision making. It is based on cost-benefit analysis, in which all costs

  3. Hydrochemical Characteristics of Groundwater in an Agricultural Area in South Korea (United States)

    Kim, N.; Hamm, S.; An, J.; Lee, J.; Jang, S.


    The study area, Sacheon-Hadong area, is located in the southern part of the Korean peninsula, which is bounded by the South Sea and surrounded by the Seomjin River in the west. The study area utilized for agricultural work for a long time. That resulted in vulnerable situation of groundwater due to contamination by fertilizer, insecticide and other human activities. In addition, groundwater is in the risk of seawater intrusion because of the study area's location nearby the South Sea. In Sacheon and Hadong area, the EC values were higher in alluvial aquifer than bedrock aquifer. The higher EC values in the alluvial groundwater than the bedrock groundwater were influenced by agricultural activity in near-surface. Water types of two groundwaters belong to Ca-Cl and Na-Cl types due to saline-water influence. EC values are raised, becoming close to the coast. The correlation analysis showed that EC had positive relationship with Na+, Ca2+, Mg2+, Fe2+, Mn2+, SO42-, and Cl-, indicating mixing with seawater. In Sacheon area, nitrogen isotope ratios in the alluvial groundwater ranged between -0.40 and 12.80‰, with 0.05~2.49 mg/l of NO3-N concentration; the range of nitrogen isotopes in the bedrock groundwater was between 3.30 and 17.60‰, with 0.12~2.14 mg/l of NO3-N concentration. Nitrogen was originated from organic source in soils, manures, and domestic wastes (Mueller and Helsel, 1996; Kim and Woo, 2003). In Hadong area, the nitrogen isotopes in the alluvial groundwater ranged from -0.50 to 19.10‰, and NO3-N concentration was between 0.63 and 6.68 mg/l. And these may be originated from anthropogenic pollutants (Mueller and Helsel, 1996). In Sacheon area, average δ18O and δD in alluvial groundwater were analyzed as - 6.77‰ and -47.50‰; average isotope ratios in bedrock groundwater were -7.73‰ and - 53.46‰. In Hadong area, average δ18O and δD in the alluvial groundwater were - 7.32‰ and -49.80‰; average isotope ratios in the bedrock groundwater

  4. 16th International Conference on Micro and Nanotechnology for Power Generation and Energy Conversion Applications (PowerMEMS 2016)

    International Nuclear Information System (INIS)


    , JAPAN Reza Ghodssi - University of Maryland Einar Halvorsen - Grenoble Alpes Université, FRANCE Hiroki Kuwano-Tohoku University, JAPAN Jeff Lang - Massachusetts Institute of Technology, USA Carol Livermore - Northeastern University, USA Ryutaro Maeda - National Institute of Advanced Industrial Science and Technology, JAPAN Kazusuke Maenaka - University of Hyogo, JAPAN Paul Mitcheson - Imperial College London, UK Yuji Suzuki - University of Tokyo, JAPAN Shuji Tanaka -Tohoku University, JAPAN Luis Velásquez-García - Massachusetts Institute of Technology, USA Peter Woias - University Freiburg-IMTEK, GERMANY Eric Yeatman - Imperial College London, UK Technical Program Committee Mahmoud Almasri, University of Missouri, USA David Arnold, University of Florida, USA Mustafa Beyaz, Antalya International University, TURKEY Danick Briand, EPFL, SWITZERLAND Stephen Burrow, Univesrity of Bristol, UK Francesco Cottone, University of Perugia, ITALY Alper Erturk, Georgia Institute of Technology, USA Luis Fonseca, IMB-CNM (CSIC)Micro-Nanosytems, SPAIN Takayuki Fujita, University of Hyogo, JAPAN Dimitri Galayko, UPMC-Sorbonne, FRANCE Tzeno Galchev, Analog Devices Inc., USA Gideon Gouws, Victoria University of Wellington, NEW ZEALAND Andrew Holmes, Imperial College London, UK Yoshihiro Kawahara, The University of Tokyo, JAPAN Sang-Woo Kim, Sungkyunkwan University, SOUTH KOREA Jeffrey Lang, Massachusetts Institute of Technology, USA Janet Ledesma-García, Universidad Autónoma de Querétaro, MEXICO Carol Livermore, Northeastern University, USA Yiannos Manoli, University of Freiburg, GERMANY Jianmin Miao, Nanyang Technological University, SINGAPORE Paul Mitcheson, Imperial College London, UK Koji Miyazaki, Kyushu Institute of Technology, JAPAN Jaeyeong Park, Kwangwoon University, KOREA Michael Renaud, Holst Centre-lmec NL, NETHERLANDS Paul Ronney, University of Southern California, USA Shad Roundy, University of Utah, USA Tomonori Seki, OMRON Corporation, JAPAN Yuji Suzuki, The

  5. INTRODUCTION Introduction to the conference proceeding of the Workshop on Electromagnetic Inverse ProblemsThe University of Manchester, UK, 15-18 June, 2009 (United States)

    Dorn, Oliver; Lionheart, Bill


    This proceeding combines selected contributions from participants of the Workshop on Electromagnetic Inverse Problems which was hosted by the University of Manchester in June 2009. The workshop was organized by the two guest editors of this conference proceeding and ran in parallel to the 10th International Conference on Electrical Impedance Tomography, which was guided by Bill Lionheart, Richard Bayford, and Eung Je Woo. Both events shared plenary talks and several selected sessions. One reason for combining these two events was the goal of bringing together scientists from various related disciplines who normally might not attend the same conferences, and to enhance discussions between these different groups. So, for example, one day of the workshop was dedicated to the broader area of geophysical inverse problems (including inverse problems in petroleum engineering), where participants from the EIT community and from the medical imaging community were also encouraged to participate, with great success. Other sessions concentrated on microwave medical imaging, on inverse scattering, or on eddy current imaging, with active feedback also from geophysically oriented scientists. Furthermore, several talks addressed such diverse topics as optical tomography, photoacoustic tomography, time reversal, or electrosensing fish. As a result of the workshop, speakers were invited to contribute extended papers to this conference proceeding. All submissions were thoroughly reviewed and, after a thoughtful revision by the authors, combined in this proceeding. The resulting set of six papers presenting the work of in total 22 authors from 5 different countries provides a very interesting overview of several of the themes which were represented at the workshop. These can be divided into two important categories, namely (i) modelling and (ii) data inversion. The first three papers of this selection, as outlined below, focus more on modelling aspects, being an essential component of

  6. How Often do Giant Black Holes Become Hyperactive? (United States)


    for field galaxies -- as some results have hinted -- but then decreased more rapidly, at some point the cluster fraction would be about equal to the field fraction. This may explain what is being seen in the local Universe. The Milky Way contains a supermassive black hole known as Sagittarius A* (Sgr A*, for short). Even though astronomers have witnessed some activity from Sgr A* using Chandra and other telescopes over the years, it has been at a very low level. If the Milky Way follows the trends seen in the ChaMP survey, Sgr A* should be about a billion times brighter in X-rays for roughly 1% of the remaining lifetime of the Sun. Such activity is likely to have been much more common in the distant past. If Sgr A* did become an AGN it wouldn't be a threat to life here on Earth, but it would give a spectacular show at X-ray and radio wavelengths. However, any planets that are much closer to the center of the Galaxy, or directly in the line of fire, would receive large and potentially damaging amounts of radiation. These results were published in the November 10th issue of the Astrophysical Journal. Other co-authors on the paper were Scott Anderson of the University of Washington, Anca Constantin from James Madison University, Tom Aldcroft and Dong-Woo Kim from Harvard-Smithsonian Center for Astrophysics and Wayne Barkhouse from the University of North Dakota. NASA's Marshall Space Flight Center in Huntsville, Ala., manages the Chandra program for NASA's Science Mission Directorate in Washington. The Smithsonian Astrophysical Observatory controls Chandra's science and flight operations from Cambridge, Mass. More information, including images and other multimedia, can be found at: and

  7. Granulated wood ash to forest soils. Effects on microorganisms, phosphorus availability, and spatial relationships in the humus layer

    International Nuclear Information System (INIS)

    Clarholm, Marianne


    according to the principal of cautiousness. Returning the increasing amounts of woo d ash coming from increased bioenergy use to the forest is also a better long term alternative than storage in a deposit with unknown future problems with leakage e.g. with heavy metals

  8. Comparison of hydration and nutritional status between young and elderly hemodialysis patients through bioimpedance analysis

    Directory of Open Access Journals (Sweden)

    Lee JE


    Full Text Available Jung Eun Lee,1,2 In Young Jo,3 Song Mi Lee,3 Woo Jeong Kim,3 Hoon Young Choi,2,4 Sung Kyu Ha,4 Hyung Jong Kim,5 Hyeong Cheon Park2,4 1Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, 2Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, 3Department of Nutrition Services, Gangnam Severance Hospital, 4Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, 5Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea Background: The number of elderly people on dialysis is increasing rapidly. Fluid overload and malnutrition status are serious problems in elderly dialysis patients. We aimed to compare the hydration and nutritional status through bioimpedance analysis (BIA between young and elderly hemodialysis (HD patients and to analyze risk factors related to fluid overload and malnutrition status in these patients.Method: We conducted a cross-sectional study, in which 82 HD (males 42, mean age 58.7±12.9 years patients were enrolled. We collected different types of data: laboratory data, such as serum creatinine, albumin, total iron-binding capacity, hemoglobin, total cholesterol; anthropometric data, such as hand grip strength (HGS; BIA data, such as intracellular water, skeletal muscle mass, body cell mass, bone mineral content, phase angle (PhA, extra cellular water (ECW/total body water (TBW ratio; and malnutrition-inflammation score (MIS, which is a traditional nutritional parameter for dialysis patients. All patients were stratified into two groups according to their age: young (<65 years [n=54] and elderly (≥65 years [n=28].Results: Total iron-binding capacity and HGS were significantly lower in elderly HD patients than in young HD patients (198.9±35.6 vs 221.4±52.1 mcg/dL; and 22.4±10.3 vs 36.4±23.2 kg, respectively (P<0.05. Also, intracellular water and Ph

  9. EDITORIAL: Invited papers from ISAMMA 2010 (Sendai, Japan, 12-16 July 2010) Invited papers from ISAMMA 2010 (Sendai, Japan, 12-16 July 2010) (United States)

    Takahashi, M.; Saito, H.


    overseas. The programme involved 4 plenary talks, 37 invited talks, 85 contributed talks and 352 posters. All submitted papers were reviewed in order to meet the standards of Journal of Physics D: Applied Physics and Journal of Physics: Conference Series. We are grateful to all participants for their valuable contributions and active discussions. We gratefully acknowledge the financial support of 17 Japanese companies and 7 Japanese foundations. Invited papers from ISAMMA 2010 Contents Current status and recent topics of rare-earth permanent magnets S Sugimoto Alloying effect on the magnetic properties of RFeB-type bulk magnets H W Chang, C C Hsieh, J Y Gan, Y T Cheng, M F Shih and W C Chang Coercivity distributions in Nd-Fe-B sintered magnets produced by the grain boundary diffusion process H Nakamura, K Hirota, T Ohashi and T Minowa Recent progress in high Bs Fe-based nanocrystalline soft magnetic alloys M Ohta and Y Yoshizawa Electric-field effects on magnetic anisotropy in Pd/Fe/Pd(0 0 1) surface Shinya Haraguchi, Masahito Tsujikawa, Junpei Gotou and Tatsuki Oda Gate modulation of spin precession in a semiconductor channel Hyun Cheol Koo, Jae Hyun Kwon, Jonghwa Eom, Joonyeon Chang, Suk Hee Han and Mark Johnson Ferromagnetic resonance of epitaxial Fe nanodots grown on MgO measured using coplanar waveguides M Mizuguchi and K Takanashi Switching phase diagrams of current-induced magnetization switching in asymmetric MgO-based magnetic tunnel junctions Seung-Young Park, Jae-Ho Han, Se-Chung Oh, Jang-Eun Lee, Kyung-Tae Nam, Hyun-Woo Lee, Younghun Jo and Kyung-Jin Lee Temperature dependence of spin-dependent transport properties of Co2MnSi-based current-perpendicular-to-plane magnetoresistive devices Y Sakuraba, K Izumi, S Bosu, K Saito and K Takanashi Adsorbate-induced spin-polarization enhancement of Fe3O4(0 0 1) A Pratt, M Kurahashi, X Sun and Y Yamauchi Antiferromagnetic coupling between spinel ferrite and α-Fe layers in Fe3-δO4/MgO/Fe(0 0 1) epitaxial films Hideto

  10. Different impacts of respiratory symptoms and comorbidities on COPD-specific health-related quality of life by COPD severity

    Directory of Open Access Journals (Sweden)

    Lee H


    Full Text Available Hyun Lee,1,* Byung Woo Jhun,1,* Juhee Cho,2–4 Kwang Ha Yoo,5 Jin Hwa Lee,6 Deog Kyeom Kim,7 Jong Deog Lee,8 Ki-Suck Jung,9 Jung Yeon Lee,10 Hye Yun Park1 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; 2Center for Clinical Epidemiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; 3Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; 4Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, South Korea; 5Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, South Korea; 6Division of Pulmonary and Critical Care Medicine, School of Medicine, Ewha Womans University, Seoul, South Korea; 7Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, South Korea; 8Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, South Korea; 9Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, Anyang, South Korea; 10Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungju Hospital, Konkuk University School of Medicine, Chungju, South Korea *These authors contributed equally to this work Background: Patients with chronic obstructive pulmonary disease (COPD often have poor health-related quality of life (HRQoL that is disproportionate to their degree of airflow limitation. This study evaluated the association between St

  11. INTRODUCTION: Anticipated changes in the global atmospheric water cycle (United States)

    Allan, Richard P.; Liepert, Beate G.


    an important example. Understanding surface solar 'dimming' and 'brightening' trends in the context of past and current changes in the water cycle are discussed in a guest editorial by Wild and Liepert (2010). The key roles anthropogenic aerosols can play on a regional scale are discussed by Lau et al (2010) through their study of the regional impact of absorbing aerosols on warming and snow melt over the Himalayas. The overarching goal of climate prediction is to provide reliable, probabilistic estimates of future changes. Relating hydrological responses back to a sound physical basis, the motivation for this special focus issue, is paramount in building confidence in anticipated changes, especially in the global water cycle. We are grateful to the reviewers and the journal editorial board for making this focus issue possible. Focus on Anticipated Changes in the Global Atmospheric Water Cycle Contents Editorials The global atmospheric water cycle Lennart Bengtsson The Earth radiation balance as driver of the global hydrological cycle Martin Wild and Beate Liepert Letters Enhanced surface warming and accelerated snow melt in the Himalayas and Tibetan Plateau induced by absorbing aerosols William K M Lau, Maeng-Ki Kim, Kyu-Myong Kim and Woo-Seop Lee Current changes in tropical precipitation Richard P Allan, Brian J Soden, Viju O John, William Ingram and Peter Good Direct versus indirect effects of tropospheric humidity changes on the hydrologic cycle S C Sherwood How closely do changes in surface and column water vapor follow Clausius-Clapeyron scaling in climate change simulations? P A O'Gorman and C J Muller Linking increases in hourly precipitation extremes to atmospheric temperature and moisture changes Geert Lenderink and Erik van Meijgaard Are climate-related changes to the character of global-mean precipitation predictable? Graeme L Stephens and Yongxiang Hu A comparison of large scale changes in surface humidity over land in observations and CMIP3 general

  12. Principles of water oxidation and O2-based hydrocarbon transformation by multinuclear catalytic sites

    Energy Technology Data Exchange (ETDEWEB)

    Musaev, Djamaladdin G [Chemistry, Emory University; Hill, Craig L [Chemistry, Emory University; Morokuma, Keiji [Chemistry, Emory University


    centers in the active site form another part of considerable interest of our grant because species with such sites [including methane monooxygenase (MMO) and more] are some of the most effective oxygenase catalysts known. Our team conducted the following research on γ-M2-Keggin complexes: (a) investigated stability of the trimer [{Fe3(OH)3(H2O)2}3(γ-SiW10O36)3]15-, 4, in water, and developed the chemistry and catalysis of the di-iron centered POM, [γ(1,2)-SiW10{Fe(OH)}2O38]6-, 5, in organic solvents (Figure 2). We also study the thermodynamic and structural stability of γ-M2-Keggin in aqueous media for different M’s (d-electron metals). We have defined two structural classes of POMs with proximally bound d-electron metal centers. We refer to these structural isomers of the {γ-M2SiW10} family of POMs as “in-pocket” and “out-of pocket”. We have elucidated the factors controlling the structure and stability of the V, Fe, Ru, Tc, Mo and Rh derivatives of [(SiO4)M2(OH)2W10O32]4- using a range of computational tools. We have: (a) demonstrated that heteroatom X in these polyanions may function as an “internal switch” for defining the ground electronic states and, consequently, the reactivity of the γ-M2-Keggin POM complexes; (b) elucidated reactivity of divacant lacunary species and polyperoxotungstates (PPTs), {Xn+O4[WO(O2)2]4}n-, which could be degradation products of γ-M2-Keggin complexes in aqueous media; (c) elucidated the role of the POM ligand in stabilization of {Ru2} and {(Ru-oxo)2} fragments in the reactant and product of the reaction of {γ-[(Xn+O4)Ru2(OH)2W10O32]}(8-n)- (where X = Si4+, P5+ and S6+) with O2, and (d) the mechanisms of olefin epoxidation catalyzed by these di-d-transition metal substituted and divacant lacunary γ-M2-Keggin complexes. III. Complementing the efforts presented above was the development of less time-consuming but reasonably accurate computational methods allowing one to explore more deeply large catalytic systems. We

  13. Nanotechnology in paper electronics (United States)

    Demming, Anna; Österbacka, Professor Ronald; Han, Jin-Woo, Dr


    The ability to put cutting edge technology on paper—not in words but in a working physical form—has been attracting an increasing number of researchers over the past decade. Paper has many advantages that make it attractive for flexible electronics: it is relatively environmentally benign; it is renewable; it can be recycled; it is light weight; production processes for paper are well advanced; and it is inexpensive. This special issue, with guest editors Ronald Österbacka from Åbo Akademi University in Finland and Jin-Woo Han from the NASA AMES Research Center, features some of the latest in paper electronics research, including developments towards applications in displays, sensing and alternative energy sources, as well as fundamental studies to further our understanding of how paper can be most effectively used in electronics. As Andrew Steckl and colleagues in the US point out, 'Cellulose-based paper substrates were implemented as an electronic substrate as early as 1969, with most advancement occurring in the past decade largely due to technology improvements in thin film deposition and organic materials' [1, 2]. They report a detailed comparison between paper, standard liquid crystal display rigid glass and flexible glass for hosting pentacene organic thin film transistors, and obtain promising results for future paper-based devices. As most meaningful electronic devices rely on transistors to function, transistors feature quite prominently in this special issue. Rodrigo Martins and colleagues in France and Portugal study the effect of fibre type, structure and dimension on paper-based transistors and reveal further insights into how paper properties affect device performance [3]. Qing Wan and colleagues in China bring the state of the art in transistor technology to paper substrates [4], fabricating indium-zinc-oxide (IZO)-based protonic/electronic hybrid thin film transistors on paper and showing that they can be used as artificial synapses. Like the

  14. EDITORIAL: Focus on Heart and Mind (United States)

    Bodenschatz, Eberhard; Wolf, Fred


    tractable to support a comprehensive analysis of functional performance at the systems level. Analogously, experimental work increasingly probes the system dynamics simultaneously at multiple levels from cell to whole organ. Here an invaluable contribution of physics to the experimental characterization of large scale activity in cardiac and neuronal tissues is the currently emerging high level of quantitative precision and control. Long-term high precision recording of large scale activity patterns of neural and cardiac tissues increasingly supports the formulation of quantitative phenomenological theories of complex dynamical states as well the realization of algorithms for manipulating and controlling them. Both quantitative phenomenology and control are not only essential for bridging theory and experiment in complex systems; they are also indispensable for turning scientific insight into diagnostic progress and improved treatment for the affected heart and mind. The present Focus Issue in New Journal of Physics reflects well the richness and excitement of this currently rapidly evolving field. It combines theoretical and experimental approaches and covers analyses ranging from the organ level over investigations of model systems to the biophysics of individual cells. The articles below represent the first contributions to this collection and further additions will appear in the near future. Focus on Heart and Mind Contents 'Heart' contributions Spiral wave drift and complex-oscillatory spiral waves caused by heterogeneities in two-dimensional in vitro cardiac tissues Sung-Jae Woo, Jin Hee Hong, Tae Yun Kim, Byung Wook Bae and Kyoung J Lee Epicardial wavefronts arise from widely distributed transient sources during ventricular fibrillation in the isolated swine heart J M Rogers, G P Walcott, J D Gladden, S B Melnick, R E Ideker and M W Kay Efficient control of spiral wave location in an excitable medium with localized heterogeneities J Schlesner, V S Zykov, H Brandtst

  15. Alledaagse omgang tussen zorgprofessionals en zorgontvangers als vindplaats voor goede (LVB zorg

    Directory of Open Access Journals (Sweden)

    Michael Kolen


    influences in observation reports (Kolen, Timmerman & Vosman, 2015, 2016. Between September 2011 and December 2012, we followed 19 young people with a mild intellectual disability (IQ 50 – 85 in their day-to-day contact with care professionals in the context of three different care organizations. Each of these young people was followed for the duration of one day. The observation reports were open-coded using tools such as the “underwater screen”. This gave us an initial impression of what is at stake for young people and for care givers in their day-to-day contact, and which institutional influences on everyday contact can be identified. We then developed a coding system. This was the first step towards understanding the dynamic that is present in day-to-day contact. In doing this, we viewed the actions of care givers, residents, and the institutional context in a praxeological manner, as doing, leaving, and undergoing (Nicolini, 2012; Schmidt, 2012; Schatzki, 2002; Schäfer, 2016; Vosman et al., 2016. The results of the coding system were processed in an extended data matrix (Miles, Huberman & Saldaña, 2013 in which the day-to-day contact between the three actors was described on the basis of scenes (Woo, Rennie & Poyntz, 2015 from the empirical material. We subsequently developed a “densified matrix” in order to identify characteristics that would make it possible to compare the scenes with each other. This resulted in three main characteristics: the actions of the resident, the actions of the care giver, and the actions of the institutional context. These three characteristics of scenes are the three dimensions of the “characteristics space” (Lazarsfeld, 1937, in which we searched for a moral orientation that manifests itself in everyday contact. We did this by analysing a series of scenes, leading us to the concept of “attending to” (Kolen, Vosman & Timmerman, 2016b. This concept is based on Hannah Arendt’s concept of power. She sees power as a

  16. FOREWORD: Imaging from coupled physics Imaging from coupled physics (United States)

    Arridge, S. R.; Scherzer, O.


    . References [1] Widlak T and Scherzer O 2012 Inverse Problems 28 084008 [2] Kuchment P and Steinhauer D 2012 Inverse Problems 28 084007 [3] Seo J K, Kim D-H, Lee J, Kwon O I, Sajib S Z K and Woo E J 2012 Inverse Problems 28 084002 [4] Tamasan A and Veras J 2012 Inverse Problems 28 084006 [5] Moradifam A, Nachman A and Timonov A 2012 Inverse Problems 28 084003 [6] Ammari H, Garnier J and Jing W 2012 Inverse Problems 28 084005 [7] Tarvainen T, Cox B T, Kaipio J P and Arridge S R 2012 Inverse Problems 28 084009 [8] Monard F and Bal G 2012 Inverse Problems 28 084001 [9] McLaughlin J, Oberai A and Yoon J R 2012 Inverse Problems 28 084004

  17. EDITORIAL Complexity of advanced radiation therapy necessitates multidisciplinary inquiry into dose reconstruction and risk assessment Complexity of advanced radiation therapy necessitates multidisciplinary inquiry into dose reconstruction and risk assessment (United States)

    Newhauser, Wayne


    -614 Stovall M, Weathers R, Kasper C, Smith S A, Travis L, Ron E and Kleinerman R 2006 Dose reconstruction for therapeutic and diagnostic radiation exposures: use in epidemiological studies Radiat. Res. 166 141-57 Taddei P J, Chell E, Hansen S, Gertner M and Newhauser W D 2010a Assessment of targeting accuracy of a low-energy stereotactic radiosurgery treatment for age-related macular degeneration Phys. Med. Biol. 55 7037-54 Taddei P J, Howell R M, Krishnan S, Scarboro S B, Mirkovic D and Newhauser W D 2010b Risk of second malignant neoplasm following proton versus intensity-modulated photon radiotherapies for hepatocellular carcinoma Phys. Med. Biol. 55 7055-65 Taddei P J, Mahajan A, Mirkovic D, Zhang R, Giebeler A, Kornguth D, Harvey M, Woo S and Newhauser W D 2010c Predicted risks of second malignant neoplasm incidence and mortality due to secondary neutrons in a girl and boy receiving proton craniospinal irradiation Phys. Med. Biol. 55 7067-80 Titt U, Mirkovic D, Sawakuchi G O, Perles L A, Newhauser W D, Taddei P J and Mohan R 2010 Adjustment of the lateral and longitudinal size of scanned proton beam spots using a pre-absorber to optimize penumbrae and delivery efficiency Phys. Med. Biol. 55 7097-106 Travis L B 2006 The epidemiology of second primary cancers Cancer Epidemiol. Biomarkers Prev. 15 2020-6 Wolkenhauer O et al 2010 Systems biologists seek fuller integration of systems biology approaches in new cancer research programs Cancer Res. 70 12-3 Xu X G, Bednarz B and Paganetti H 2008 A review of dosimetry studies on external-beam radiation treatment with respect to second cancer induction Phys. Med. Biol. 53 R193-241 Yepes P, Mirkovic D and Taddei P J 2010 A GPU implementation of a track-repeating algorithm for proton radiotherapy dose calculations Phys. Med. Biol. 55 7107-20 Zhang R, P\\'{e}rez-And\\'{u}jar A, Fontenot J D, Taddei P J and Newhauser W D 2010 An analytic model of neutron ambient dose equivalent and equivalent dose for proton radiotherapy Phys. Med