Sample records for savio lau-ching woo

  1. WooCommerce cookbook

    CERN Document Server

    Rauland, Patrick


    If you have ever built or managed a WordPress site and want to add e-commerce functionality into your site, WooCommerce and this book are perfect for you. Learning how to use WooCommerce through this series of recipes will give you a solid platform to add any future e-commerce needs.


    Directory of Open Access Journals (Sweden)

    Albertus Suwarto


    Full Text Available Penelitian ini bertujuan untuk mengetahui pelaksanaan PPB di  SMP Pangudi Luhur Domenico Savio Semarang tahun pelajaran 2010/2011 dilihat dari: 1 konteks pelaksanaan PPB, 2 input program PPB, 3 proses pelaksanaan program pembelajaran PPB, dan 4 output program. Pengambilan data dilakukan dengan kuesioner, dokumentasi, wawancara dan observasi untuk data kualitatif. Analisis data dilakukan secara deskriptif.  Hasil penelitian menunjukkan: pertama, konteks pelaksanaan PPB menunjukkan hasil tinggi 62,8%. Pelaksa-naan PBB dari sisi konteks dapat dilaksanakan dengan baik. Kedua, input program menun-jukkan hasil tinggi, 85,2%. Pelaksanaan PBB dari sisi input dapat dilaksanakan dengan baik. Ketiga, proses pelaksanaan program menunjukkan hasil tinggi, 79,7% berarti pelaksanaan PBB dari sisi proses dilaksanakan dengan baik. Keempat, produk pelaksanaan program yaitu: (a ujian/test formatif, (b ujian/test semester, (c ujian nasional dan (d prestasi kegiatan ekstrakurikuler menunjukkan hasil tinggi,74,1%. Hal ini berarti pelaksanaan PBB dari sisi produk dikatakan baik. Kata kunci : persepsi, program percepatan belajar, cipp

  3. Kolm Armastust ja Anarhiat. Nekrofiil, drellimõrvar ja John Woo Tallinnas / Jaan Ruus

    Index Scriptorium Estoniae

    Ruus, Jaan, 1938-2017


    Helsingi filmifestivali "Armastus ja Anarhia" mitme seansi toimumisest Eestis 1993.a. septembris : Abel Ferrara "Drellimõrvar" ("Driller Killer", 1979), sakslase Jörg Buttgereiti "Nekromantik" (1987) ja "Nekromantik 2" (1991), John Woo "Hard Boiled" (1993). Buttgereit ja Woo olid ka ise kohal

  4. Wooing-Scenes in “Richard III”: A Parody of Courtliness?

    Directory of Open Access Journals (Sweden)

    Agnieszka Stępkowska


    Full Text Available In the famous opening soliloquy of Shakespeare’s Richard III, Richard mightily voices his repugnance to “fair well-spoken days” and their “idle pleasures”. He realizes his physical deformity and believes that it sets him apart from others. He openly admits that he is “not shaped for sportive tricks, nor made to court an amorous looking-glass”. Yet, his monstrosity constitutes more perhaps of his aggressive masculine exceptionality rather than of his deformity. Richard’s bullying masculinity manifests itself in his contempt for women. In the wooing scenes we clearly see his pugnacious pursuit of power over effeminate contentment by reducing women to mere objects. Additionally, those scenes are interesting from a psychological viewpoint as they brim over with conflicting emotions. Therefore, the paper explores two wooing encounters of the play, which belong the best examples of effective persuasion and also something we may refer to as ‘the power of eloquence’.

  5. Cross-cultural adaptation and validation of the Italian version of the Western Ontario Osteoarthritis of the Shoulder index (WOOS). (United States)

    Corona, Katia; Cerciello, Simone; Morris, Brent Joseph; Visonà, Enrico; Merolla, Giovanni; Porcellini, Giuseppe


    The Western Ontario Osteoarthritis of the Shoulder index (WOOS) has been introduced as a disease-specific quality of life measurement in patients with glenohumeral arthritis. The aim of the present study was to perform a cross-cultural adaptation of the English version of the WOOS to Italian and to assess its validity, reliability and responsiveness in patients with glenohumeral joint osteoarthritis treated conservatively. The adaptation process was carried out following the simplified Guillemin criteria. The English version was translated into Italian by two bilingual orthopaedic surgeons and then translated back into English by two different bilingual orthopaedic surgeons. The original version was compared with the back-translation. The questionnaire was prospectively administered to 30 patients with glenohumeral osteoarthritis at baseline and again after 5 days for retest reliability. After 6 months of conservative treatment, the responsiveness of the questionnaire was assessed in a subsample of 20 patients. The level of statistical significance was set at 0.05. The interclass correlation coefficient between test and retest of the WOOS was 0.99 (P < 0.001). Pearson's correlation coefficient between the WOOS and disability of the arm, shoulder and hand (DASH) preoperatively was 0.73 (P < 0.01) and the correlation between the changes of score for the WOOS and DASH was 0.75 (P < 0.01). There were no floor or ceiling effects. Responsiveness, calculated by standardized response mean, was 1.1 and effect size was 1.3. The Italian version of the WOOS questionnaire has shown to be equivalent to its English version and demonstrated good validity, reliability and responsiveness to conservative treatment of glenohumeral osteoarthritis. Level II.

  6. Jämförelse mellan Drupal Commerce och WooCommerce : CASE: Arcada Shop


    Lintu, Maya


    Examensarbetet behandlar ett produktutvecklingsprojekt som utfördes i samarbete med kommunikationsenheten vid yrkeshögskolan Arcada. Syftet med arbetet var att komma fram till vilket innehållshanteringssystem och nätbutiksverktyg som skulle användas för att skapa en nätbutik för Arcada. I arbetet görs en jämförelse mellan Drupal och WordPress samt deras nätbutiksverktyg Drupal Commerce och WooCommerce för att få fram det bättre alternativet för Arcada Shop. Forskningen begrän...

  7. Climate change, water supply and environmental problems of headwaters: The paradigmatic case of the Tiber, Savio and Marecchia rivers (Central Italy). (United States)

    Di Matteo, Lucio; Dragoni, Walter; Maccari, David; Piacentini, Simone Maria


    River headwaters, in spite of their importance for habitats and water supply, are often inadequately studied and managed. This study discusses the effects of the hydrogeological system and climatic variations on the environment of Monte Fumaiolo (Central Italy), which corresponds to the headwaters of the rivers Tiber, Savio and Marecchia. The area is a key system for supplying drinking-water and is also the habitat of amphibians such as the endemic and endangered Bombina pachypus and other amphibian species. Ongoing climate change is affecting the area: during the last 30years, five prolonged droughts have occurred, against only one in the preceding 40years. On all time-scales, there is a decrease in rainfall during the recharge period and an increase of temperature: these trends correspond to a decrease in water yield of about 12% over the last 30years. The hydrologic system of the study area is composed of one basic aquifer and a few perched aquifers feeding springs. Their resilience to drought depends on their geological setting: study of some depletion curves helped us to understand the geological setting of the various types, and two promising sites for the habitat preservation of amphibians were identified. Study results indicate new approaches to the study and management of the environment and its water supply, which could be useful in similar areas. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Entre la planeación urbana, la apropiación del espacio y la participación ciudadana. Los pactos ciudadanos y el Parque Biblioteca España de Santo Domingo Savio In the midst of Urban Planning, Space Appropriation and Citizen Participation. Citizen Pacts and Santo Domingo Savio's Library Park España

    Directory of Open Access Journals (Sweden)

    María Eugenia González Vélez


    Full Text Available Es te artículo presenta una reflexión sobre modelos de ciudad, planificación urbana y prácticas ciudadanas a través del estudio de caso de las transformaciones arquitectónicas y urbanas dadas en Medellín desde las últimas administraciones (2004-2007; 2008-2011 y, más específicamente, aquellas que han tenido lugar en el barrio Santo Domingo Savio, en la comuna uno de la zona nororiental de Medellín en relación con el proyecto del Parque Biblioteca España. El urbanismo social, bandera de estas administraciones, ha promovido procesos de transformación arquitectónica y social en búsqueda de la inclusión de sectores históricamente marginados; que conjuga diversas relaciones de confrontación y genera una integración social que no se aleja de la imagen marginal, sino que genera espacios políticos y de representación donde pese a las transformaciones, la marginalidad de estos lugares persiste como marco histórico e interpretativo que permite hacer ''legible'' para la alcaldía y para la ciudad este territorio.This article presents a reflection on city models, urban planning and citizen practices based on the case study of the architectonic and urban transformations of Medellín (Colombia during the last two administrations (2004-2007; 2008-present year and, more specifically, those that took place in the neighborhood of Santo Domingo Savio, located in the North-East zone of Medellín in relation to the Library Park España project. Social urbanism, one of the leader projects of these administrations, has promoted social and architectonic transformation processes in looking for the inclusion of the historically marginalized sectors. This integration faces different confrontational relationships and generates a social integration that does not draw away the marginal images of the neighborhood. On the contrary, it generates political and representational spaces where, despite of the transformations, the marginality persists as a

  9. Entre la planeación urbana, la apropiación del espacio y la participación ciudadana. Los pactos ciudadanos y el Parque Biblioteca España de Santo Domingo Savio

    Directory of Open Access Journals (Sweden)

    María Eugenia González Vélez


    Full Text Available Este artículo presenta una reflexión sobre modelos de ciudad, planificación urbana y prácticas ciudadanas a través del estudio de caso de las transformaciones arquitectónicas y urbanas dadas en Medellín desde las últimas administraciones (2004-2007; 2008-2011 y, más específicamente, aquellas que han tenido lugar en el barrio Santo Domingo Savio, en la comuna uno de la zona nororiental de Medellín en relación con el proyecto del Parque Biblioteca España. El urbanismo social, bandera de estas administraciones, ha promovido procesos de transformación arquitectónica y social en búsqueda de la inclusión de sectores históricamente marginados; que conjuga diversas relaciones de confrontación y genera una integración social que no se aleja de la imagen marginal, sino que genera espacios políticos y de representación donde pese a las transformaciones, la marginalidad de estos lugares persiste como marco histórico e interpretativo que permite hacer “legible” para la alcaldía y para la ciudad este territorio.

  10. Sulfoxidation with hydrogen peroxide catalyzed by [SeO(4){WO(O(2))(2)}(2)](2-). (United States)

    Kamata, Keigo; Hirano, Tomohisa; Ishimoto, Ryo; Mizuno, Noritaka


    The selenium-containing dinuclear peroxotungstate, [(n-C(4)H(9))(4)N](2)[SeO(4){WO(O(2))(2)}(2)] (I), acts as a homogeneous catalyst for the selective oxidation of various kinds of cyclic mono- and disulfides with 30% aqueous H(2)O(2). The cyclic disulfides were selectively oxidized to the corresponding monosulfoxides with one equivalent of H(2)O(2) with respect to the sulfides. In the presence of two equivalents of H(2)O(2), the oxidation of dibenzothiophene gave the corresponding sulfone in 98% yield under the mild conditions. The negative Hammett rho value (-0.62) for the competitive oxidation of p-substituted thioanisoles and the low X(SO) (X(SO) = (nucleophilic oxidation)/(total oxidation)) value of 0.14 for the I-catalyzed oxidation of thianthrene 5-oxide (SSO) revealed that I is a strong electrophilic oxidant. The reactivities of the di- and tetranuclear peroxotungstates with XO(4)(n-) ligands (X = Se(vi), As(v), P(v), S(vi), and Si(iv)) were strongly dependent on the kinds of hetero atoms. The reaction rates for the sulfoxidation decreased with an increase in the X(SO) values and a peroxotungstate with a stronger electrophilicity was more active for the sulfoxidation. The kinetic and mechanistic investigations showed that the electrophilic attack of the peroxo oxygen at the sulfur atom is a key step in the sulfoxidation. The computational investigation supported the high chemoselectivitiy for the sulfoxidation of diallyl sulfide.

  11. Sandwich-type zinc-containing polyoxometalates with a hexaprismane core [{Zn2W(O)O3}2]4+ synthesized by thermally induced isomerization of a metastable polyoxometalate. (United States)

    Kikukawa, Yuji; Yamaguchi, Kazuya; Mizuno, Noritaka


    Two novel sandwich-type silicotungstates, TBA(8)[{Zn(2)W(O)O(3)}(2)H(4){α-SiW(9)O(33)}(2)]·5H(2)O (α-Zn4; TBA = tetra-n-butylammonium) and TBA(8)[{Zn(2)W(O)O(3)}(2)H(4){β-SiW(9)O(33)}(2)]·7H(2)O (β-Zn4), were synthesized by the solid-state thermally induced isomerization of metastable TBA(8)[{Zn(OH(2))(μ(3)-OH)}(2){Zn(OH(2))(2)}(2){γ-HSiW(10)O(36)}(2)]·9H(2)O (γ-Zn4). Compounds α-Zn4 and β-Zn4 consisted of two [SiW(9)O(33)](8-) subunits sandwiching the unprecedented distorted hexaprismane core [{Zn(2)W(O)O(3)}(2)](4+).

  12. Temporal Vulnerability and the Post-Disaster 'Window of Opportunity to Woo:' a Case Study of an African-American Floodplain Neighborhood after Hurricane Floyd in North Carolina. (United States)

    de Vries, Daniel H


    After major flooding associated with Hurricane Floyd (1999) in North Carolina, mitigation managers seized upon the "window of opportunity" to woo residents to accept residential buyout offers despite sizable community resistance. I present a theoretical explanation of how post-crisis periods turn into "opportunities" based on a temporal referential theory that complements alternative explanations based on temporal coincidence, panarchy, and shock-doctrine theories. Results from fieldwork conducted from 2002 to 2004 illustrate how several temporal influences compromised collective calibration of "normalcy" in local cultural models, leading to an especially heightened vulnerability to collective surprise. Four factors particularly influenced this temporal vulnerability: 1) epistemological uncertainty of floodplain dynamics due to colonization; 2) cultural practices that maintained a casual amnesia; 3) meaning attributed to stochastic timing of floods; and 4) competitive impact of referential flood baseline attractors.

  13. The first korean doctor of medicine in ophthalmology: early career of Kong pyung woo (1907-1995) as an unusual example of medical profession in colonial Korea. (United States)

    Kim, Tae-Ho


    This article traces early career of Kong Pyung Woo, a public figure famous for being the first doctor of medicine in ophthalmology with Korean ethnicity in 1936, for founding and running the oldest and still the most successful private eye clinic in Korea since 1937, and also for his engagement in development of Korean mechanical typewriter since 1949. His case is an illustrative example of how a Korean under the Japanese colonial rule (1910-1945) could build up a career to become a medical doctor, taking full advantage of the chances available. Kong, born in 1907 in a rural province in northwestern Korea, acquired a doctor's license in 1926 by passing the qualifying examination of the Government General in Korea. The qualification test was in itself an outcome of colonial education system, in which the supply of medical doctors by only a few tertiary schools could not meet the demands. After working for a state hospital for one year, Kong volunteered to be a visiting student at Keijo Medical College, to fulfill his dream of "becoming a prominent bacteriologist like Noguchi Hideyo." He was soon officially appointed as a tutor at Department of Ophthalmology, as he had been endorsed by professor Satake Shyuichi for his diligence and earnestness. Satake also encouraged Kong to pursue a doctoral degree and recommended him to Tokumitsu Yoshitomi, a professor in the Department of Pathology at Keijo Imperial University, so that Kong could experience cutting-edge research at the imperial university. Kong reported on his experiments on the pathology of chorioretinitis centralis by 1935. He submitted the reports to Nagoya Imperial University, Japan, as a doctoral thesis, and eventually obtained the degree in 1936, which was the first Korean doctor of medicine in ophthalmology. The doctorate made Kong a public figure and he opened his own private clinic in 1937. The Kong Eye Clinic was the first private eye clinic owned and run by Korean, and soon became popular in Seoul

  14. Mozart, Hawthorne, and Mario Savio: Aesthetic Power and Political Complicity. (United States)

    Herbert, T. Walter


    Discusses the false dichotomy pitting aesthetic power against political complicity in literary criticism. Considers the sexual politics of the household of Nathaniel Hawthorne in light of this opposition. Suggests how literary works keep warring voices and inner conflicts alive and at odds. (HB)

  15. Linear Collider partners woo newly opened India

    CERN Multimedia

    Bagla, Pallava


    "With the wheels of Air Force One barely off the tarmac following U.S. President George W. Bush's visit, which ended India's 3 decades as a nuclear pariah state, a delegation of U.S. and European physicists arrived here last week to discuss India's involvement in the International Linear Collider."

  16. Do Gametes Woo? Evidence for Their Nonrandom Union at Fertilization. (United States)

    Nadeau, Joseph H


    A fundamental tenet of inheritance in sexually reproducing organisms such as humans and laboratory mice is that gametes combine randomly at fertilization, thereby ensuring a balanced and statistically predictable representation of inherited variants in each generation. This principle is encapsulated in Mendel's First Law. But exceptions are known. With transmission ratio distortion, particular alleles are preferentially transmitted to offspring. Preferential transmission usually occurs in one sex but not both, and is not known to require interactions between gametes at fertilization. A reanalysis of our published work in mice and of data in other published reports revealed instances where any of 12 mutant genes biases fertilization, with either too many or too few heterozygotes and homozygotes, depending on the mutant gene and on dietary conditions. Although such deviations are usually attributed to embryonic lethality of the underrepresented genotypes, the evidence is more consistent with genetically-determined preferences for specific combinations of egg and sperm at fertilization that result in genotype bias without embryo loss. This unexpected discovery of genetically-biased fertilization could yield insights about the molecular and cellular interactions between sperm and egg at fertilization, with implications for our understanding of inheritance, reproduction, population genetics, and medical genetics. Copyright © 2017 by the Genetics Society of America.


    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Ornelas Berriel


    Full Text Available Anton Francesco Doni “a été un des tempéraments les plus vivaces, les plus désabusés,les plus vivants, les plus cinquecenteschi qui se soient déjà présentés sur notre terre”; avec ces mots d'admiration avouée, Carlo Curcio présente celui qui a été tout à la fois “rebelle et hérétique, immorale et fustigateur de l’immoralité des autres, sacré et profane, turbulent et méditatif,insouciant et angoissé”. L’élément le plus révélateur du caractère singulier du Doni écrivain utopiste du Seizième par rapport aux autres auteurs d’utopies de sa période est peut-être sa volontéde “ne pas écrire pour les princes et savants, mais pour le peuple, intéressé à des solutions simples et directes pour leurs problèmes”. Monde Savant et Fou, publié en 1552, que nous présentons ettraduisons en portugais le long de ces pages, est une des prémières à reprendre le paradigme utopique en sens strict.

  18. Who's Wooing Whom II? An Experimental Investigation of Date-Initiation and Expectancy Violation. (United States)

    Mongeau, Paul A.; Carey, Colleen M.


    States that recent studies on first-date expectations and enactments indicated that men evaluate female-initiated first dates in more sexual ways than do females. Cautions that results also indicate that participants reported less intimacy on such dates. Uses expectancy violation theory to investigate the conflicting results. Finds that…

  19. Chickalicious: Want to Woo Reluctant Female Readers? Chick Lit May Be the Ticket (United States)

    Meloni, Christine


    Five years ago, when the author transferred from a local elementary school to her current position, she took one look at the dismal circulation figures and knew she had her work cut out for her. One of the first things she did was create a graphic novel section to attract young male readers. She also began stocking up on guy-friendly adventure and…

  20. Guía para la implantación de un sistema de seguridad y salud ocupacional en la Casa Domingo Savio


    Yturralde Villagómez, Juan Gabriel; Jácome Cevallos, Mike Nehemías


    Esta tesis está desarrollada para prevenir y disminuir los riesgos en cada una de las áreas de la Casa Salesiana “Domingo Savio” El estudio de factibilidad se desarrolla en la Casa Salesiana “Domingo Savio” y dentro de sus objetivo es el mejoramiento continuo de la institución, por tal motivo se gestiona el presente estudio, con el fin de ganar el prestigio como identidad educativa incluyente de la seguridad y salud ocupacional para sus empleados y estudiantes, a su vez brindar ...

  1. To Twitter to Woo: Harnessing the power of social media (SoMe) in nurse education to enhance the student's experience. (United States)

    Sinclair, Wendy; McLoughlin, Moira; Warne, Tony


    This paper explores some of the difficulties, challenges and rewards for student nurses and nurse academics when harnessing social media (SoMe) as part of the overall learning experience. The paper draws upon data in the form of student voices, captured through an online planned Twitter chat. This data analysis provides the basis of a case study on the student experience in practice placements. A planned 1 h Twitter chat took place in June 2013, specifically aimed at student nurses. What transpired was an illuminating debate, eliciting responses from around the globe about learning in practice, mentors, and student support that lasted over 3 h. More importantly, the Twitter chat also included qualified nurses and mentors, listening and responding in real time, offering thoughts and solutions to how support and mentoring could be improved. This was in contrast to how students, locally, currently use a paper based questionnaire to give feedback in isolation. The authenticity of this feedback is often compromised by university link lecturers' who often provide a more sanitised version of this feedback to clinical placement. This paper explores whether it is possible to facilitate a realignment and capture the zeitgeist in order to provide the opportunity for enhancing learning in practice. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Highly efficient oxidation of sulfides with hydrogen peroxide catalyzed by [SeO(4){WO(O(2))(2)}(2)](2-). (United States)

    Kamata, Keigo; Hirano, Tomohisa; Mizuno, Noritaka


    By using the selenium-containing dinuclear peroxotungstate at 0.005-0.1 mol%, various kinds of sulfides could be converted into the corresponding sulfoxides or sulfones in excellent yields with one or two equivalents of H(2)O(2) with respect to the sulfide, respectively.

  3. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Aaron Savio Lobo. Articles written in Resonance – Journal of Science Education. Volume 12 Issue 5 May 2007 pp 60-70 General Article. The Bycatch Problem - Effects of Commercial Fisheries on Non-Target Species in India · Aaron Savio Lobo · More Details ...

  4. 2. Home 3. Journals 4. Resonance–Journal of Science Education 5 ...

    Indian Academy of Sciences (India)

    Ancient Temple. Arul Lakshminarayan. 48 Mechanochemistry. The Amazing Viral DNA Packaging Molecular. Motor. K L Sebastian. 60 The Bycatch Problem. Effects of Commercial Fisheries on Non-Target. Species in India. Aaron Savio Lobo. 71 Gödel's Proof. Incompleteness Theorems. S M Srivastava. BOOK REVIEWS.

  5. The Bycatch Problem

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 12; Issue 5. The Bycatch Problem - Effects of Commercial Fisheries on Non-Target Species in India. Aaron Savio Lobo. General Article Volume 12 Issue 5 May 2007 pp 60-70 ...

  6. Recent advances in elasticity, viscoelasticity and inelasticity

    CERN Document Server

    Rajagopal, KR


    This is a collection of papers dedicated to Prof T C Woo to mark his 70th birthday. The papers focus on recent advances in elasticity, viscoelasticity and inelasticity, which are related to Prof Woo's work. Prof Woo's recent work concentrates on the viscoelastic and viscoplastic response of metals and plastics when thermal effects are significant, and the papers here address open questions in these and related areas.

  7. Geopressured-geothermal aquifers. Final contract report

    Energy Technology Data Exchange (ETDEWEB)


    Task 1 is to provide petrophysical and reservoir analysis of wells drilled into geopressured-geothermal aquifers containing dissolved methane. The list of Design Wells and Wells of Opportunity analyzed: Fairfax Foster Sutter No. 2 (WOO), Pleasant Bayou No. 2 (Design), Amoco Fee No. 1 (Design), G.M. Koelemay No. 1 (WOO), Gladys McCall No. 1 (Design), P.R. Girouard No. 1 (WOO), and Crown Zellerbach No. 2 (WOO). Petrophysical and reservoir analysis of the above wells were performed based on availability of data. The analysis performed on each well, the assumptions made during simulation, and conclusions reached.

  8. Rasch analysis of the Western Ontario Osteoarthritis of the Shoulder index – the Danish version

    DEFF Research Database (Denmark)

    Moeini, Sahar; Rasmussen, Jeppe Vejlgaard; Klausen, Tobias Wirenfeldt


    PURPOSE: The Western Ontario Osteoarthritis of the Shoulder (WOOS) index is a disease-specific, patient-reported, 19-question survey that measures the quality of life among patients with osteoarthritis (OA). The purpose of this study was to validate the Danish version of WOOS for OA and fractures...... (FRs) using modern test theory. PATIENTS AND METHODS: The study included 1,987 arthroplasties in 1,943 patients that were reported to the Danish Shoulder Arthroplasty Register between 2006 and 2011. These included 847 OA and 1,140 FR cases. RESULTS: Principal component analysis indicated...... the unidimensionality of WOOS. The person reliabilities showed a floor-ceiling effect, indicating that a dichotomy was the best fit for the WOOS scale. For OA, WOOS showed good reliability (item and person reliability of 0.98 and 0.76) and good targeting, with a person mean of -0.56 logits. FR also showed good...

  9. War Gamers Handbook: A Guide for Professional War Gamers (United States)


    depicted in Figure 2. Player activities may include physically placing game pieces on a large map display to facilitate awareness of space , time, objectives. The knowledge manager, in close concert with the Gaming Tech Branch, determines the number of computer work stations required by...USN, and LCDR Savio Cavalcanti, Brazilian Navy, Inter-American War Game 2013 control group members, plot player force positioning using an MTMU

  10. Revision of the genus Salganea Stål (Blattodea, Blaberidae, Panesthiinae from China, with descriptions of three new species

    Directory of Open Access Journals (Sweden)

    Xiudan Wang


    Full Text Available Three new species of Salganea Stål, 1877 are described and illustrated: S. quinquedentata sp. n., S. anisodonta sp. n. and S. flexibilis sp. n. S. taiwanensis Roth, 1979, S. guangxiensis (Feng & Woo, 1990, S. incerta (Brunner von Wattenwyl, 1893 and S. raggei Roth, 1979 are redescribed. Panesthia concinna Feng & Woo, 1990 is synonymized with S. taiwanensis Roth, 1979 and Panesthia guangxiensis Feng & Woo, 1990 is transferred to the genus Salganea for the first time. As well, a key to species from China is presented.

  11. Revision of the genus Salganea Stål (Blattodea, Blaberidae, Panesthiinae) from China, with descriptions of three new species. (United States)

    Wang, Xiudan; Shi, Yan; Wang, Zongqing; Che, Yanli


    Three new species of Salganea Stål, 1877 are described and illustrated: S. quinquedentata sp. n., S. anisodonta sp. n. and S. flexibilis sp. n. S. taiwanensis Roth, 1979, S. guangxiensis (Feng & Woo, 1990), S. incerta (Brunner von Wattenwyl, 1893) and S. raggei Roth, 1979 are redescribed. Panesthia concinna Feng & Woo, 1990 is synonymized with S. taiwanensis Roth, 1979 and Panesthia guangxiensis Feng & Woo, 1990 is transferred to the genus Salganea for the first time. As well, a key to species from China is presented.

  12. Traveling with children (United States)

    ... 175. Woo R. Avoid foodborne illness when traveling abroad. Updated October 5, 2011. Web site. ... URAC's accreditation program is an independent audit to verify that A.D.A.M. ...

  13. Genetics Home Reference: Bloom syndrome (United States)

    ... Central Ouyang KJ, Woo LL, Ellis NA. Homologous recombination and maintenance of genome integrity: cancer and aging ... B, Bohr VA. Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging. Biogerontology. ...

  14. Fulltext PDF

    Indian Academy of Sciences (India)

    University of Leicester),. D Mukhopadhyay (University of Calcutta), Woo. Hun Ryang (Chonbuk National University, Korea),. Nicholas Eyles (University of Toronto), Stuart. Bull (University of Tasmania), Bruce Cairncross. (Rand Afrikaans University) ...

  15. Eto vam ne Dzheims Bond / Vincent Vega

    Index Scriptorium Estoniae

    Vega, Vincent


    Actionfilmi "Võimatu missioon" ("Mission : Impossible") järg "Võimatu Missioon 2 ("Mission : Impossible II") : režissöör John Woo : peaosaline ja produtsent Tom Cruise : Ameerika Ühendriigid 2000

  16. Souli millenniumivärav / Maria-Kristiina Soomre

    Index Scriptorium Estoniae

    Soomre, Maria-Kristiina, 1978-


    Millenniumi tähistamiseks Souli plaanitavast hiigelehitisest "Souli ring", mis peaks valmima 2003. a. Arhitektuurse lahenduse autorid Lee Eun-seok ja Woo Dae-seung firmast Op'us Architects & Co. Eri ringkondade arvamusi projekti kohta.

  17. Disease: H00292 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available R, Woo A, Ralph-Edwards A, Butany J Hypertrophic cardiomyopathy: current understanding and treatment objec...tives. J Clin Pathol 62:226-35 (2009) PMID:19568388 (drug) Marian AJ Contemporary t

  18. 78 FR 26342 - Small Hydro of Texas, Inc.; Notice of Application Accepted for Filing, Soliciting Comments... (United States)


    ... Hydro of Texas, Inc. e. Name of Project: Cuero Hydroelectric Project. f. Location: Guadalupe River, 2.5.... P.O. Box 1667, Victoria, TX 77902 (361) 571-4626. i. FERC Contact: Mr. Henry Woo, (202) 502-8872...

  19. Kes kardab Park Chan-Wooki? / Karlo Funk

    Index Scriptorium Estoniae

    Funk, Karlo, 1971-


    Vägivalla ajendite teemadel. USA meedia süüdistas peale Virginia koolitulistamist filmikunsti. Seoseid ja/või põhjusi otsiti korealase Park Chan-Wooki filmist "Vana poiss" ("Old Boy") ja John Woo filmidest

  20. Large-Scale Interaction Effects Reveal Missing Heritability in Schizophrenia, Bipolar Disorder and Posttraumatic Stress Disorder (United States)


    Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Fort Detrick, MD, USA . Correspondence: Dr HJ Woo or Dr J...21702, USA . E-mail: or Received 21 July 2016; revised 18 January 2017; accepted 10 February 2017 Citation...severe inflation of AUCs and refrained from global quality control filtering based on the P-values. Pathway/gene-based SNP selection We used 1730

  1. Functions within the Naval Air Training Command (United States)


    number. For X = N: Chief of Naval Air Training (CNATRA) Staff W: Training Air Wing ( TRAWING ) A: Naval Air Station (NAS) 3; Training Squadron...Provide assistance as required to TRAWING commands in preparation and execution of budget within the framework of guidance provided by CNATRA and...higher authority, WOO-69 Establish monetary controls as required to effectively monitor budget execution for TRAWING commands. WOO-70 Maintain

  2. Reliability Factors for Electronic Components in a Storage Environment (United States)


    should expect that narrowing choices to even a few models to describe these complex sums of many processes is unlikely. 176 A -Aid References 1. Galileo ... Galilei Linceo, Discorsi e Diraostrazioni Matematiche: Intorna a Due Nuoue Sienze•tte-nt: lia- e--canica &-i--ovi-mnti Locali (Leyden, 1638) H. Crew & A. de Sa-vio, ialouaues Coneeming Two New Scijnces, Gafileo Galilei (MacMillan, 1914, reprinted by Dover, New York) a) pp. 94-98; b) pp

  3. IPS y el Tercer Mundo

    Directory of Open Access Journals (Sweden)

    Roberto Savio


    Full Text Available CHASQUI, entrevistó al periodista italo-argentino Roberto Savio, director fundador de la IPS, quien respondió a interrogantes como: En América Latina no hay sociedades de comunicación sino de información? ¿ Por qué y cúal la diferencia? ¿Cómo se puede hacer una sociedad comunicacional en A. Latina? ¿Cuál es la diferencia entre comunicación alternativa y popular? ¿Qué hacer para ampliar el mercado de lectores?¿Qué opina de ASIN y ALASE?

  4. Comparison of the Specificity of MR-EIT and Dynamic Contrast-Enhanced MRI in Breast Cancer (United States)


    tomography (MREIT): phantom experiments for static resistivity images IEEE Trans. Med. Imaging 21 695–702 Kwon O, Woo E J, Yoon J R and Seo J K 2002...Woo E J, Lee S Y, Cho M H, Kwon O, Seo J K and Baek W S 2003 Static resistivity image of a cubic saline phantom in magnetic resonance electrical... OPAMPs . This current source was triggered by a TTL pulse generated by the scanner computer. The current cables were connected to the object through

  5. Outcome, revision rate and indication for revision following resurfacing hemiarthroplasty for osteoarthritis of the shoulder

    DEFF Research Database (Denmark)

    Rasmussen, J V; Polk, A; Sorensen, A K


    In this study, we evaluated patient-reported outcomes, the rate of revision and the indications for revision following resurfacing hemiarthroplasty of the shoulder in patients with osteoarthritis. All patients with osteoarthritis who underwent primary resurfacing hemiarthroplasty and reported...... to the Danish Shoulder Arthroplasty Registry (DSR), between January 2006 and December 2010 were included. There were 772 patients (837 arthroplasties) in the study. The Western Ontario Osteoarthritis of the Shoulder (WOOS) index was used to evaluate patient-reported outcome 12 months (10 to 14) post.......001), but with no increased risk of revision. There was no significant difference in the mean WOOS or the risk of revision between designs of resurfacing hemiarthroplasty....

  6. Resurfacing hemiarthroplasty compared to stemmed hemiarthroplasty for glenohumeral osteoarthritis

    DEFF Research Database (Denmark)

    Rasmussen, Jeppe V; Olsen, Bo S; Sorensen, Anne Kathrine


    PURPOSE: The aim of this study was to conduct a randomised, clinical trial comparing stemmed hemiarthroplasty and resurfacing hemiarthroplasty in the treatment of glenohumeral osteoarthritis. METHODS: A total of 40 shoulders (35 patients) were randomised to stemmed hemiarthroplasty or resurfacing...... hemiarthroplasty and evaluated three and 12 months postoperatively using the Constant-Murley score (CMS) and Western Ontario Osteoarthritis of the Shoulder (WOOS) index. RESULTS: There were no statistically significant differences in age, gender or pre-operative scores except for WOOS at baseline. Two patients...

  7. Resurfacing shoulder arthroplasty for the treatment of severe rheumatoid arthritis

    DEFF Research Database (Denmark)

    Voorde, Pia C Ten; Rasmussen, Jeppe V; Olsen, Bo S


    with adjustment for age, sex, and previous surgery. RESULTS: During the study period, 167 patients underwent shoulder arthroplasty because of rheumatoid arthritis, 80 (48%) of whom received RHA and 34 (26%) of whom received SHA. 16 patients were treated with total stemmed shoulder arthroplasty (TSA), and 24 were...... treated with reverse shoulder arthroplasty (rTSA). 130 patients returned a completed questionnaire, and the total mean WOOS score was 63. The cumulative 5-year revision rate was 7%. Most revisions occurred after RHA, with a revision rate of 14%. Mean WOOS score was similar for RHA and for SHA...

  8. Characterization of MWCNT/Nanoclay Binary Nanoparticles Modified Composites and Fatigue Performance Evaluation of Nanoclay Modified Fiber Reinforced Composites (United States)


    uniform dispersion of nanoparticles in resin. 3.3.2 Dispersion of Montmorillonite nanoclay into epoxy resin Nanoclays are hydrophilic organoclays prone...C., Woo, R., & Sham, M. (2005). Moisture barrier characteristics of organoclay ?epoxy nanocomposites. Composites Science and Technology, 65(5), 805

  9. Muusikauudiseid maailmast / Ia Remmel

    Index Scriptorium Estoniae

    Remmel, Ia, 1965-


    Lühisõnumeid maailmast: Suri Einojuhani Rautavaara. ECHO Klassiku 2017. aasta preemia saajad selgunud. Bachi haruldane käsikiri oksjonil. "Operalia 2016" võitjad on Keon-Woo Kim ja Elsa Dreisig. Shakespeare'i Globe asutas oma plaadimärgi. Sydney konkursi vitis vene pianist Andrei Gugnin. Noorel rootsi viiuldajal leping Deutsche Grammophoniga

  10. Investigation of nonionic diazo dye-doped polymer dispersed liquid ...

    Indian Academy of Sciences (India)

    doped polymer dispersed liquid crystal film. FARZANA AHMAD1, MUHAMMAD JAMIL1−3, YOUNG JAE JEON1,∗. , LEE JIN WOO1,. JAE EUN JUNG4 and JAE EUN JANG4. 1Department of Chemistry, 3Department of Physics, Konkuk University, ...

  11. Fuelling Economic Growth: The Role of Public–Private Sector ...

    International Development Research Centre (IDRC) Digital Library (Canada)


    Apr 26, 2009 ... Changes in the balance of funding are an important marker of evolution in the nature of research systems, with critical implications for public policy and the ... At the time of the book's publication, Jean Woo was a program officer in the Innovation, Policy and Science program at the International Development ...

  12. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    pp 329-338 Articles. Characterization of the Helicoverpa assulta nucleopolyhedrovirus genome and sequence analysis of the polyhedrin gene region · Soo-Dong Woo Jae Young Choi Yeon Ho Je Byung Rae Jin · More Details Abstract Fulltext PDF. A local strain of Helicoverpa assulta nucleopolyhedrovirus (HasNPV) was ...

  13. Surfactant-assisted sacrificial template-mediated synthesis ...

    Indian Academy of Sciences (India)

    Heena Khajuria

    precursor and products were characterized by powder X-ray diffraction, fourier transform infrared spectroscopy, field emission scanning electron ... can be easily transformed into rare-earth oxides by ther- mal decomposition without any ..... Park J Y, Baek M J, Choi E S, Woo S, Kim J H, Kim. T J, Jung J C, Chae K S, Chang Y ...

  14. Synthesis, characterization, scale-up and catalytic behaviour of ...

    Indian Academy of Sciences (India)

    tron microscopy (TEM), Fourier-transform infrared (FT-IR) spectrum and Nuclear magnetic resonance (NMR). The XRD measurements show cubic spinel phase and Debye–Scherrer ..... and Beller M 2013 J. Am. Chem. Soc. 135 10776. 38. Chun S W, Jang J Y, Park D W, Woo H C and Chung J S 1997. Korean J. Chem.

  15. A substitution mutation in OsCCD7 cosegregates with dwarf and ...

    Indian Academy of Sciences (India)

    ∗For correspondence. E-mail: Dee-geo-woo-gen, which was used to develop the semidwarf cultivar IR8 that produced record yields throughout Asia and formed the basis for the development of several high yield, semidwarf varieties. Since then, sd1 has remained the pre- dominant dwarfing gene to ...

  16. Promoting Industrialisation in Mauritius, South Africa and Botswana ...

    African Journals Online (AJOL)

    independence, Mauritius was a sugar-based monoculture, with a stagnating. GDP per capita of ... domestic product (GDP), and sugar alone accounted for over 90 per cent of ... tax incentives. The government also developed strong partnerships and networks, especially with Asian investors. The government actively wooed.


    African Journals Online (AJOL)


    Br J Cancer 4(4): 347-367. Borger, J, Kemperman, H, Hart, A, Peterse, H, van. Dongen, J, Bartelink, H (1994) Risk factors in breast-conservation therapy. J Clin Oncol 12. (4): 653-660. Cao, D, Lin, C, Woo, SH, Vang, R, Tsangaris, TN,. Argani, P (2005) Separate cavity margin sam- pling at the time of initial breast lumpectomy.

  18. Ancient and modern environmental DNA

    DEFF Research Database (Denmark)

    Pedersen, Mikkel Winther; Overballe-Petersen, Søren; Ermini, Luca


    DNA obtained from environmental samples such as sediments, ice or water (environmental DNA, eDNA), represents an important source of information on past and present biodiversity. It has revealed an ancient forest in Greenland, extended by several thousand years the survival dates for mainland woo...

  19. A Framework for Interaction and Cognitive Engagement in Connectivist Learning Contexts (United States)

    Wang, Zhijun; Chen, Li; Anderson, Terry


    Interaction has always been highly valued in education, especially in distance education (Moore, 1989; Anderson, 2003; Chen, 2004a; Woo & Reeves, 2007; Wang, 2013; Conrad, in press). It has been associated with motivation (Mahle, 2011; Wen-chi, et al., 2011), persistence (Tello, 2007; Joo, Lim, & Kim, 2011), deep learning (Offir, et al.,…

  20. Higher Education and Entrepreneurial Citizenship in Singapore (United States)

    Christensen, Soren


    Focusing on Singapore's "Global Schoolhouse" project, this article discusses how efforts to transform Singapore into a "world class" knowledge economy entail changes to the status of citizenship in Singapore. The project of wooing top foreign universities to Singapore is permeated with an entrepreneurial ideal of Singapore as…

  1. Identification and chromosomal localization of repeat sequences ...

    Indian Academy of Sciences (India)


    The aim of this research was to identify and localise re- peat sequences in Korean cattle (Hanwoo), which may be a basis for future genetic studies. To achieve this, a Han- woo BAC library containing a total of 150,000 clones with an average size of 130–140 kb was constructed us- ing two different restriction enzymes ...

  2. Integrated DoD Voice and Data Networks and Ground Packet Radio Technology (United States)


    also been well-studied. Several algorithms are found in the litera- ture [CHOU, 1973], ( ESAU , 1966], [WOO, 1973]. Typically, the algorithms solve...Data Communications Symposium, St. Peters- burg, Florida, November 13-15, 1973. ( ESAU , 1966] Esau , L.R. and K.C. Williams, "On Teleproces- sing

  3. Nematicidal, Larvicidal and Antimicrobial Activities of Some New ...

    African Journals Online (AJOL)

    Xiangxiong Chen1*, Seung Woo Lee1, Akbar Idhayadhulla2, Radhakrishnan. Surendra Kumar3 and Aseer Manilal4. 1School of Chemical Engineering, Yeungnam University, Gyeongsan, South Korea, 2Department of Chemistry, School of Basic. Sciences, Vels Institute of Science, Technology & Advanced Studies - VELS ...

  4. FIB and CVD Fabrication of Carbon Nanostructures on Diamond and Quartz Substrates (United States)


    Quang Trung Tran, Sung Hong Hahn, Jin Suk Chung, Eun Woo Shin, Eui Jung Kim, Optoelectronic properties of graphene thin films prepared by thermal...91. [50] Boudou JP, Paredes JI , Cuesta A, Martine-Alonso A, Tascon JMD. Oxygen plasma modification of pitch-based isotropic carbon fibres. Carbon

  5. Plasma Theory and Simulation (United States)


    34Collisionless Plasma Sheath in Cylindrical Geometry" Phys. Fluids. 6. 1963, pp 1657-1658. T G. Emmert, R. Wieland, A. Mense , and J. Davidson, ’Electric Sheath and...Library, Lebouef, Meier, Mook Guillory, Rowland, Winske Physics International University of New Mexico Woo Anderson, Humphries Princeton Plasma Physics

  6. Nigerian Journal of Paediatrics - Vol 40, No 2 (2013)

    African Journals Online (AJOL)

    ... FULL TEXT DOWNLOAD FULL TEXT. EN Ekure, CI Esezobor, MR Balogun, JG Woo, M Mukhtar-Yola, OO Ojo, IJ Emodi, AI Omoigberale, AO Olowu, WN Ogala, DO Esangbedo, 112-118 ... FULL TEXT DOWNLOAD FULL TEXT. O Oniyangi, P Ahmed, OT Otuneye, J Okon, HA Aikhionbare, OO Olatunji, AO Akano, 158-164 ...

  7. Comparison of the G-174C polymorphism of interleukin (IL)-6 in ...

    African Journals Online (AJOL)



    Apr 5, 2012 ... Diao H, Kohanawa M (2005) Endogenous interleukin-6 plays a crucial protective role in streptococcal toxic shock syndrome via suppression of tumor necrosis factor alpha production. Infect. Immun. 73: 3745-. 3748. Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries. S, Woo P (1998) ...

  8. Effects of Folic Acid Intake on Serum Lipid Profiles of Apparently ...

    African Journals Online (AJOL)

    Samuel B. Olaleye

    reduction in serum cholesterol and LDL-C (p<0.05) while there was large scale increase in HDL-C. (P<0.05). Furthermore, the ... the 10mg folic acid intake resulted in significant decrease in serum triacylglycerol concentration (P<0.05). These results .... heart disease (Nelson and Cox , 2000; Woo et al.,. 2002). The increase ...

  9. Fraud and misconduct in science: the stem cell seduction: Implications for the peer-review process

    NARCIS (Netherlands)

    van der Heyden, M. A. G.; van de Ven, T. Derks; Opthof, T.


    Scientific misconduct and fraud occur in science. The (anonymous) peer review process serves as goalkeeper of scientific quality rather than scientific integrity. In this brief paper we describe some limitations of the peer-review process. We describe the catastrophic facts of the 'Woo-Suk Hwang

  10. 77 FR 28598 - Proposed Data Collections Submitted for Public Comment and Recommendations (United States)


    ... Americans (Carter- Pokras & Woo, 2002). Few studies thus far, however, have explored factors in the... strategies to reduce these health and safety risks.'' CDC/NIOSH requests OMB approval to collect standardized... the ages of 18 and 65, English-speaking, either currently employed or unemployed for no more than 3...

  11. Expression of porcine myosin heavy chain 1 gene in Berkshire loins ...

    African Journals Online (AJOL)

    Expression of porcine myosin heavy chain 1 gene in Berkshire loins with a high pH24 value. Jin Hun Kang, Woo Young Bang, Eun Jung Kwon, Yong Hwa Lee, Da Hye Park, Eun Seok Cho, Min Ji Kim, Jong-Soon Choi, Hwa Chun Park, Beom Young Park, Chul Wook Kim ...

  12. Turbine Engine Control Synthesis. Volume 2. Simulation and Controller Software (United States)


    r with TIGV and PIGV’ are used to compute the axial component of velocity in the stage: VWC1D T G (A-14)• Vzl , TGV , PIGV] which in turn is used to...compressor section include spool speed, inlet parameters Woo Pop and T., and compressor geometry control positions TGV and BLD. Steady-state pressure and

  13. Relating Health to Platform Success: Exploring Three E-commerce Ecosystems

    NARCIS (Netherlands)

    Alami, Daniel; Rodriquez, Maria; Jansen, Slinger


    The market for e-commerce systems is saturated with more than 60 different solutions that compete and try to accommodate different needs. However, it appears that three main platforms account for roughly half of the market share: Magento, PrestaShop, and WooCommerce. This paper evaluates these

  14. Synthesis of carbon nanotubes by catalytic vapor decomposition ...

    Indian Academy of Sciences (India)

    (Chem. Sci.) 113, 375 (2001). [21] A Fonseca, K Hernadi, P Piedigrosso, J-F Colomer, K Mukhopadhyay, R Doome, S. Lazarescu, L P Biro, Ph Lambin, P A Thiry, D Bernaerts and J B Nagy, Appl. Phys. A67, 11 (1998). [22] C J Lee, Seung Chul Lyu, Hyoun-Woo Kim, Chong-Yun Park and Cheol-Woong Yang,. Chem. Phys.

  15. CORRIGENDUM: The relationship between electromechanical cyclic loading and the performance degradation of a smart bending piezoelectric actuator The relationship between electromechanical cyclic loading and the performance degradation of a smart bending piezoelectric actuator (United States)

    Woo, Sung-Choong; Goo, Nam Seo


    This corrigendum corrects a citation error in our article (Woo et al 2009 Smart Mater. Struct. 18 104021) in which the journal name of the reference [14] is wrongly cited as 'Smart Mater. Struct. 39 2433-7' instead of 'J. Phys. D: Appl. Phys. 39 2433-7' on page 10.


    African Journals Online (AJOL)

    northwestern Amazon region of Brazil," respectively. These variations may be due to the differences in methodology and the populations used. While Kleinstein et al.,"Faderin and Ajaiyeoba," and Woo et al“ used a population ofstudents andchildren, this study madeuse ofametropic patients ofallages. Also, while Faderin and.

  17. Reining in H2O2 for Safe Signaling


    Planson, Anne-Gaëlle; Delaunay‐Moisan, Agnès


    Mammalian cells use hydrogen peroxide (H(2)O(2)) not only to kill invading pathogens, but also as a signaling modulator. Woo et al. (2010) now show that the local inactivation of a H(2)O(2)-degrading enzyme ensures that the production of this oxidant is restricted to the signaling site.

  18. Formulation and Pharmacokinetic Evaluation of Controlled-Release ...

    African Journals Online (AJOL)

    Controlled-Release Oxybutynin Tablets in Dogs. Joonho Bae1 and Jin Woo Park2*. 1Amorepacific Corporation R&D Center, 314-1, Bora-dong, Giheung-gu, Yongin-si, Gyeonggi-do, 446-729, 2College of. Pharmacy and Natural Medicine Research Institute, Mokpo National University, 1666 Youngsan-ro, Muan-gun, ...

  19. Synthesis of N-acylurea derivatives from carboxylic acids and N,N ...

    Indian Academy of Sciences (India)

    Synthesis of N-acylurea derivatives from carboxylic acids and. N,N -dialkyl carbodiimides in water. ALI RAMAZANIa,∗, FATEMEH ZEINALI NASRABADIb, ARAM REZAEIa,. MORTEZA ROUHANIc, HAMIDEH AHANKARd, PEGAH AZIMZADEH ASIABIa,. SANG WOO JOOe,∗. , KATARZYNA SLEPOKURAf and TADEUSZ LISf.

  20. A Strategy for Evaluating Pathway Analysis Methods (United States)


    1 A strategy for evaluating pathway analysis methods Chenggang Yu, Hyung Jun Woo, Xueping Yu+, Tatsuya Oyama, Anders Wallqvist, Jaques Reifman... practically applying such pathway analysis (PA) methods, we must first evaluate their performance and reliability, using datasets where the pathways...unavailable. Furthermore, previous evaluation strategies that have focused on defining ‘true answers’ are unable to systematically and objectively assess PA

  1. Author Details

    African Journals Online (AJOL)

    Woo, Boyun. Vol 39, No 2 (2017) - Articles Emotional labour, emotional exhaustion, job satisfaction and organisational citizenship behaviour among Korean fitness employees. Abstract. ISSN: 0379-9069. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about ...

  2. The Rhetoric of the Troubadours

    Directory of Open Access Journals (Sweden)

    Mary C. Abraham


    Full Text Available The medieval troubadours were no wandering musicians, casually improvising their songs as they strolled from town to town, but trained artists who lovingly crafted their songs to please and woo their listeners. The art of rhetoric deeply affected the art of the troubadour. First, the art of rhetoric divided composition of a speech into five well-defined parts. The troubadours consciously molded their songs according to these parts. Second, the medieval troubadour theorists then developed a system of genres, adding their own layer to the ancient art of rhetoric. Each genre demanded a specific topic, such as love, and a peculiar approach to that topic. Finally, the art of rhetoric also inspired a close union of the poems and their melodies. The troubadours were no wandering musicians, casually improvising their songs as they strolled from town to town, but trained artists who lovingly crafted their songs to please and woo their listeners.

  3. Stem-cell spin: Covering the Hwang-affair in Science and Nature

    DEFF Research Database (Denmark)

    Kjærgaard, Rikke Schmidt


    In 2006 the South Korean cloning expert Woo Suk Hwang was found guilty of fraud and scientific misconduct. The scandal was reaching far beyond Hwang’s own laboratory encompassing national pride, geopolitics and regional discussions of stem-cell research. But the HIn 2006 the South Korean cloning...... expert Woo Suk Hwang was found guilty of fraud and scientific misconduct. The scandal reached far beyond Hwang’s own laboratory, encompassing national pride, geopolitics and global discussions of stem-cell research. But the Hwang affair was also a case of fierce competition between two of the world......’s leading scientific journals. Individually, Science and Nature used the Hwang affair and their unique positions to air specific and conflicting agendas resulting in completely different narratives as the scandal unfolded. In Science, where Hwang’s fraudulent papers were published, the readers learned about...

  4. Communication assisted Localization and Navigation for Networked Robots (United States)


    the CSIRO helicopter team: Jonathan Roberts, Gregg Buskey, Srikanth Saripalli (University of Southern California), Graeme Winstanley, Leslie Overs... Culler , D. Estrin, , and S. Wicker. Complex behavior at scale: An experimental study of lowpower wireless sensor networks. UCLA Computer Science...Hawaii International Conference on System Sciences (HICSS ’00), Jan. 2000. 24 [23] J. Hill, R. Szewczyk, A. Woo, S. Hollar, D. Culler , and K. Pister

  5. Plasma Theory and Simulation. (United States)


    11 En rg ,, IO - -612 10 - 13, , 0 500 1000 1500 t Fig. 1 Mode 1 energy versus time for cold plasm oscillatin run CID2. 26- SIr /At - 4/w PAt2 (19...Wagner Zabusky Sandia Laboratories, Albuquerque University of Texas Freeman, Poukey, Quintenz, Humphries Horton, McMahon, Tajima Sandia Laboratories...Thomas Gell University of California, Davis Tel-Aviv University DeGroot, Woo Cuperman University of California, Irvine Kyoto University Rynn Abe

  6. Proceedings of the Environmental Systems Symposium (13th) Held at Bethesda, Maryland on 20-22 March 1984. (United States)


    prorm is an outdoor classrom at the Post lmetryShool. oughwo us* of this classroomF teache have gaunt an Increased Ability ami confide to teach eow...installatios and a major Amy hospital (rraybill, Mallen and Donahue, IO) . Six major hazardous wates wore fonds (1) waste oil/petroluin oil lubricant (Pa... Hospital ", CKRL-TR-MI-90, Aug. 1980, U .S. Amy Construction engineering Research Laboratory, Cmpip, Illinois. Woo., C., at Sl., "hatifn the Xuard

  7. Scalable, Self Aligned Printing of Flexible Graphene Micro Supercapacitors (Postprint) (United States)


    reduced graphene oxide: 0.4 mF cm−2)[11,39–41] prepared by conventional micro- fabrication techniques, the printed MSCs offer distinct advan- tages in...AFRL-RX-WP-JA-2017-0318 SCALABLE, SELF-ALIGNED PRINTING OF FLEXIBLE GRAPHENE MICRO-SUPERCAPACITORS (POSTPRINT) Woo Jin Hyun, Chang-Hyun Kim...including suggestions for reducing this burden, to Department of Defense, Washington Headquarters Services, Directorate for Information Operations

  8. Growth and basic wood properties of black spruce along an alti-latitudinal gradient in Quebec, Canada


    Rossi, Sergio; Cairo, Ernesto; Krause, Cornelia; Deslauriers, Annie


    International audience; Abstract• ContextThe Canadian forest industry is turning its attention towards the unmanaged areas at higher latitudes, where the forest resource is still poorly understood because of lack of accessibility. Despite a lower productivity in terms of volume, northern stands are expected to produce wood of higher quality, which may make these areas attractive for management and production.• AimsThis study aims to test the hypothesis that trees at high latitudes produce woo...

  9. Fraud and misconduct in science: the stem cell seduction (United States)

    van der Heyden, M.A.G.; van de Ven, T.; Opthof, T.


    Scientific misconduct and fraud occur in science. The (anonymous) peer review process serves as goalkeeper of scientific quality rather than scientific integrity. In this brief paper we describe some limitations of the peer-review process. We describe the catastrophic facts of the ‘Woo-Suk Hwang fraud case’ and raise some ethical concerns about the issue. Finally, we pay attention to plagiarism, autoplagiarism and double publications. (Neth Heart J 2009;17:25-9.) PMID:19148335

  10. Boomers versus Millennials: Online Media Influence on Media Performance and Candidate Evaluations


    Terri Towner; Caroline Lego Munoz


    Facebook posts, YouTube videos, tweets and wooing political bloggers have become standard practice in marketing political campaigns. Research has demonstrated the effect of new media on a host of politically-related behavior, including political participation, knowledge acquisition, group formation and self-efficacy. Yet, issues related to media trust, media performance and candidate evaluations have not been fully explored. In addition, much of the political marketing research looks exclusiv...

  11. Collective Genetic Interaction Effects and the Role of Antigen Presenting Cells in Autoimmune Diseases (United States)


    information contained within genome-wide associa- tion studies to improve individual prediction of complex disease risk. Hum Mol Genet . 2009; 18 (18):3525–31...Rosenstiel P, Albrecht M, Stenzel A, et al. Sarcoidosis is associated with a truncating splice site mutation in BTNL2. Nat Genet . 2005; 37(4):357–64. Epub...RESEARCH ARTICLE Collective Genetic Interaction Effects and the Role of Antigen-Presenting Cells in Autoimmune Diseases Hyung Jun Woo*, Chenggang Yu

  12. In-Storage Embedded Accelerator for Sparse Pattern Processing (United States)


    Laboratory, * MIT Computer Science & Artificial Intelligence Laboratory Abstract— We present a novel system architecture for sparse pattern... learning , and graph processing . [5][6][7]. A recent effort, the GraphBLAS [8], aims to standardize some of these computational kernels in order to...In-Storage Embedded Accelerator for Sparse Pattern Processing Sang-Woo Jun * , Huy T. Nguyen # , Vijay Gadepally #* , and Arvind * # MIT Lincoln

  13. Navy Carrier Battle Groups: The Structure and Affordability of the Future Force (United States)


    Embassy, Tokyo, Japan U.S. Embassy, Kuala Lumpur, Malaysia U.S. Embassy, Singapore U.S. Embassy, Bangkok, Thailand U.S. Embassy, Ankara, Turkey U.S...Ministry of Foreign Affairs Malaysia Institute of Strategic and International Studies, Kuala Lumpur University of Malaysia , Kuala Lumpur Singapore...1591 1992 Calendar year Mediterraniean Sao - Western Pacific Ocean " Nestl Indian 0asan/Arabian Seam WOO I Total Note: Because theso deployment levels

  14. The Effect of Hominis Placenta Herbal Acupuncture on Bell's palsy


    Yun Jeong-hun; Yook Tea-han; Song Beom-yong


    This report was done to observe the effect of Hominis placenta herbal acupuncture on Bell's palsy. The study group comprised 16 patients who arrived at Woo-suk university oriental hospital from January, 1999 till January, 2000 for Bell's palsy. All patients were divided into two group. One was herbal acupunture group, and the other was control group. Acupunture group was done herbal acupuncture therapy on the facial acupuncture points. Followings are achievement and a term of each group. I...

  15. Fraud and misconduct in science: the stem cell seduction: Implications for the peer-review process. (United States)

    van der Heyden, M A G; van de Ven, T; Opthof, T


    Scientific misconduct and fraud occur in science. The (anonymous) peer review process serves as goalkeeper of scientific quality rather than scientific integrity. In this brief paper we describe some limitations of the peer-review process. We describe the catastrophic facts of the 'Woo-Suk Hwang fraud case' and raise some ethical concerns about the issue. Finally, we pay attention to plagiarism, autoplagiarism and double publications. (Neth Heart J 2009;17:25-9.).

  16. Set Up for Failure: The Use of US Security Force Assistance to Prepare Foreign Security Forces for Traditional Combat Operations (United States)


    advice , and assistance.5 Lastly, US Army doctrine defines SFA as the unified action to generate, employ, and sustain local, host-nation, or regional...dismissed opposition, rejected advice , and rationalized his ways.84 One thing can be certain; his optimism was not grounded in reality. Second Case...air or naval support in case of a conflict in 86 Young -woo Lee, “The United States and the

  17. IWR-MAIN Water Use Forecasting System. Version 5.1. User’s Manual and System Description (United States)


    2051 Bread, Cake & Ret. Prods 120 225 Knitting Mills 2052 Cookies & Crackers 29 226 Textile Flnlshng,exc.Woot...... 206 Sugar & Confectionery prd... Confectionery Products 1013 207 Fats & Oils 1014 208 Beverages 1015 2082 Malt Beverages 1016 2086 Bottled & Canned Soft Drinks 1017 2087 Flavoring Extracts...225 Knitting Mills 11 2052 Cookies & Crackers .... 226 Textile Finishng,exc.WooL ....... 206 Sugar & Confectionery prd 37 227 Floor Covering

  18. Early Sámi visual artists - Western fine art meets Sámi culture

    Directory of Open Access Journals (Sweden)

    Tuija Hautala-Hirvioja


    Full Text Available Johan Turi (1854–1936, Nils Nilsson Skum (1872–1951 and John Savio (1902–1938 were among the first Sámi visual artists. The production of their art work occurred between the 1910s and the early 1950s. Sámi aesthetics had its basis in folklore, i.e., handicraft or duodji, which did not follow the principle of art for art’s sake but combined beauty and practicality. Art was part of community life. Not until the 1970s was the word daidda, which is Finnish in origin and which means “art”, adopted into the Sámi language. Turi and Skum became famous through their books. They drew and wrote in order to pass the traditional knowledge of their people on to succeeding generations. They also wanted to introduce Sámi life and culture to non-Sámi people. One typical feature of their work is that they depicted Sáminess in a realistic way and sought to strengthen and preserve the Sámi identity through their art. In Turi and Skum’s work, both the documentation of community life and their own personal expression were strongly present and equally important; for this reason their pictures and texts have both practical and aesthetic dimensions. They did not attend school and were self-taught artists. The third pioneer of Sámi visual arts was John Savio, who, unlike the other two, attended secondary school and studied visual arts both independently and under the guidance of a mentor. He expressively combined Western ways of depiction with Sámi subjects. My article examines what made these early Sámi artists change over from Sámi handicraft, duodji, to Western visual arts, how they used Western pictorial conventions in dealing with their Sámi subjects, and the significance of their art for Sámi identity and culture. They lived and worked under cross pressure: the first few decades of the 20th century were characterized by racial theories that denigrated Sámi people, and the period following World War II was marked by demands for


    Directory of Open Access Journals (Sweden)

    G. Bitelli


    Full Text Available The present study aims to demonstrate the usefulness of GIS to support archive searches and historical studies (e.g. related to industrial archaeology, in the case of an ancient channel for mill powering near Cesena (Emilia-Romagna, Italy, whose history is weaved together with the history of the Compagnia dei Molini di Cesena mill company, the most ancient limited company in Italy. Several historical maps (about 40 sheets in total inherent the studied area and 80 archive documents (drawings, photos, specifications, administrative acts, newspaper articles, over a period of more than 600 years, were collected. Once digitized, historical maps were analysed, georeferenced and mosaicked where necessary. Subsequently, in all the maps the channel with its four mills and the Savio river were vectorized. All the additional archive documents were digitized, catalogued and stored. Using the QGIS open source platform, a Historical GIS was created, encompassing the current cartographic base and all historical maps, with their vectorized elements; each archive document was linked to the proper historical map, so that the document can be immediately retrieved and visualized. In such a HGIS, the maps form the base for a spatial and temporal navigation, facilitated by a specific interface; the external documents linked to them complete the description of the represented elements. This simple and interactive tool offers a new approach to archive searches, as it allows reconstruction in space and time of the evolution of the ancient channel and the history of this important mill company.


    Directory of Open Access Journals (Sweden)

    G. Bitelli


    Several historical maps (about 40 sheets in total inherent the studied area and 80 archive documents (drawings, photos, specifications, administrative acts, newspaper articles, over a period of more than 600 years, were collected. Once digitized, historical maps were analysed, georeferenced and mosaicked where necessary. Subsequently, in all the maps the channel with its four mills and the Savio river were vectorized. All the additional archive documents were digitized, catalogued and stored. Using the QGIS open source platform, a Historical GIS was created, encompassing the current cartographic base and all historical maps, with their vectorized elements; each archive document was linked to the proper historical map, so that the document can be immediately retrieved and visualized. In such a HGIS, the maps form the base for a spatial and temporal navigation, facilitated by a specific interface; the external documents linked to them complete the description of the represented elements. This simple and interactive tool offers a new approach to archive searches, as it allows reconstruction in space and time of the evolution of the ancient channel and the history of this important mill company.

  1. Effect of prothioconazole-based fungicides on Fusarium head blight, grain yield and deoxynivalenol accumulation in wheat under field conditions

    Directory of Open Access Journals (Sweden)



    Full Text Available The effect of triazole-based treatments on Fusarium head blight (FHB, grain yields and the accumulation of deoxynivalenol (DON in harvested wheat kernels was evaluated by means of twenty multi-site field experiments performed during five consecutive growing seasons (from 2004‒2005 to 2008‒2009 in Italy. Fungicide treatments were carried out on different cultivars of common wheat (cv. Serio, Blasco, Genio and Savio and durum wheat (cv. Orobel, Saragolla, San Carlo, Levante, Duilio, Karur and Derrik after artificial inoculation with a mixture of toxigenic Fusarium graminearum and F. culmorum strains. The application of fungicides containing prothioconazole (Proline® or Prosaro® at the beginning of anthesis (BBCH 61 resulted in a consistent reduction of FHB disease severity (by between 39 and 93% and DON levels in wheat kernels (by between 40 and 91% and increased wheat yields (from 0.4 to 5.6 t ha-1, average 2.2 t ha-1, as compared to the untreated/inoculated control. Fungicides containing tebuconazole (Folicur® SE and cyproconazole plus prochloraz (Tiptor® Xcell showed a reduced effectiveness compared with prothioconazole-based treatments. All fungicide treatments were more effective in reducing DON and increasing grain yields of common wheat than durum wheat. Results showed that the application of fungicides containing prothioconazole at the beginning of anthesis provided a strong reduction of FHB disease, allowing both an increase in grain yields and a considerable reduction of DON content in wheat kernels.

  2. Hgis and Archive Researches: a Tool for the Study of the Ancient Mill Channel of Cesena (italy) (United States)

    Bitelli, G.; Bartolini, F.; Gatta, G.


    The present study aims to demonstrate the usefulness of GIS to support archive searches and historical studies (e.g. related to industrial archaeology), in the case of an ancient channel for mill powering near Cesena (Emilia-Romagna, Italy), whose history is weaved together with the history of the Compagnia dei Molini di Cesena mill company, the most ancient limited company in Italy. Several historical maps (about 40 sheets in total) inherent the studied area and 80 archive documents (drawings, photos, specifications, administrative acts, newspaper articles), over a period of more than 600 years, were collected. Once digitized, historical maps were analysed, georeferenced and mosaicked where necessary. Subsequently, in all the maps the channel with its four mills and the Savio river were vectorized. All the additional archive documents were digitized, catalogued and stored. Using the QGIS open source platform, a Historical GIS was created, encompassing the current cartographic base and all historical maps, with their vectorized elements; each archive document was linked to the proper historical map, so that the document can be immediately retrieved and visualized. In such a HGIS, the maps form the base for a spatial and temporal navigation, facilitated by a specific interface; the external documents linked to them complete the description of the represented elements. This simple and interactive tool offers a new approach to archive searches, as it allows reconstruction in space and time of the evolution of the ancient channel and the history of this important mill company.

  3. Post-death cloning of endangered Jeju black cattle (Korean native cattle): fertility and serum chemistry in a cloned bull and cow and their offspring. (United States)

    Kim, Eun Young; Song, Dong Hwan; Park, Min Jee; Park, Hyo Young; Lee, Seung Eun; Choi, Hyun Yong; Moon, Jeremiah Jiman; Kim, Young Hoon; Mun, Seong Ho; Oh, Chang Eon; Ko, Moon Suck; Lee, Dong Sun; Riu, Key Zung; Park, Se Pill


    To preserve Jeju black cattle (JBC; endangered native Korean cattle), a pair of cattle, namely a post-death cloned JBC bull and cow, were produced by somatic cell nuclear transfer (SCNT) in a previous study. In the present study, we examined the in vitro fertilization and reproductive potentials of these post-death cloned animals. Sperm motility, in vitro fertilization and developmental capacity were examined in a post-death cloned bull (Heuk Oll Dolee) and an extinct nuclear donor bull (BK94-13). We assessed reproductive ability in another post-death cloned cow (Heuk Woo Sunee) using cloned sperm for artificial insemination (AI). There were no differences in sperm motility or developmental potential of in vitro fertilized embryos between the post-death cloned bull and its extinct nuclear donor bull; however, the embryo development ratio was slightly higher in the cloned sperm group than in the nuclear donor sperm group. After one attempt at AI, the post-death cloned JBC cow became pregnant, and gestation proceeded normally until day 287. From this post-death cloned sire and dam, a JBC male calf (Heuk Woo Dolee) was delivered naturally (weight, 25 kg). The genetic paternity/maternity of the cloned JBC bull and cow with regard to their offspring was confirmed using International Society for Animal Genetics standard microsatellite markers. Presently, Heuk Woo Dolee is 5 months of age and growing normally. In addition, there were no significant differences in blood chemistry among the post-death cloned JBC bull, the cow, their offspring and cattle bred by AI. This is the first report showing that a pair of cattle, namely, a post-death cloned JBC bull and cow, had normal fertility. Therefore, SCNT can be used effectively to increase the population of endangered JBC.

  4. 18F-fluoromisonidazole PET and Activity of Neoadjuvant Nintedanib in Early HER2-Negative Breast Cancer: A Window-of-Opportunity Randomized Trial. (United States)

    Quintela-Fandino, Miguel; Lluch, Ana; Manso, Luis; Calvo, Isabel; Cortes, Javier; García-Saenz, José Angel; Gil-Gil, Miguel; Martinez-Jánez, Noelia; Gonzalez-Martin, Antonio; Adrover, Encarna; de Andres, Raquel; Viñas, Gemma; Llombart-Cussac, Antonio; Alba, Emilio; Guerra, Juan; Bermejo, Begoña; Zamora, Esther; Moreno-Anton, Fernando; Pernas Simon, Sonia; Carrato, Alfredo; Lopez-Alonso, Antonio; Escudero, María José; Campo, Ruth; Carrasco, Eva; Palacios, José; Mulero, Francisca; Colomer, Ramon


    Purpose: We previously detected promising efficacy of neoadjuvant nintedanib (a multityrosine kinase inhibitor, TKI) in early HER2-negative breast cancer. In a preclinical study, we monitored stromal hypoxia with 18F-fluoromisonidazole-positron emission tomography (18F-FMISO-PET); we found that reoxygenation of tumors (or lack of it) during a window-of-opportunity (WoO) treatment with TKIs correlated with the benefit (or lack of it) from TKI-plus-chemotherapy combinations. We studied the predictive role of 18F-FMISO-PET for the TKI nintedanib in the neoadjuvant setting in a phase II WoO randomized trial.Experimental Design: Patients were randomized to a 14-day WoO of nintedanib preceded and followed by an 18F-FMISO-PET, followed by nintedanib plus weekly paclitaxel (Arm A) or an 18F-FMISO-PET followed by weekly paclitaxel (Arm B) before surgery. The endpoint was residual cancer burden (RCB). The objective was to detect the patients with no response (RCB-III) on the basis of the baseline or evolutive 18F-FMISO-PET values/changes.Results: One-hundred and thirty HER2-negative patients were randomized. Seventeen (27.9%), 34 (55.7%), and 8 (13.1%) patients had an RCB of III, II, and I/0, respectively, in Arm A. In this arm, baseline hypoxic tumors had a 4.4-fold higher chance of experiencing RCB = 3 (P = 0.036) compared with baseline normoxic tumors. Nintedanib WoO induced tumor reoxygenation in 24.5% of the patients; those not reoxygenating showed a trend toward higher chance of experiencing RCB-III (6.4-fold; P = 0.09). In Arm B, 18F-FMISO-PET lacked predictive/prognostic value.Conclusions: Baseline hypoxic tumors (measured with 18F-FMISO-PET) do not benefit from neoadjuvant nintedanib. Clin Cancer Res; 23(6); 1432-41. ©2016 AACR. ©2016 American Association for Cancer Research.

  5. Beginnings of Group Cohomology

    Indian Academy of Sciences (India)

    a·f(a) + f(a) = Zo + zo, so that Zo = -Zo; that is Zo is purely imaginary, so that Zo = zo/2 - (zo)/2 = a(zo/2) - (zo/2), which shows that f is a 1-coboundary; that is Hl(G, C) = O. On the other hand, let f : G -+ C* be a 1-cocycle. Then by an argument as above, we have f(1) = 1 and f is determined by f(a) = woo We have 1 = f(1) = f(a2. ) ...

  6. Design and Real-Time Implementation of a Robust APC Coder for Speech Transmission over 16 Kb/s Noisy Channels. Volume II. Real-Time Implementation. (United States)


    ift 0 m a C Woo :wow Ab omm W.. 106 a C I- : O’F a ,Wgx g ug I. a fq., :.X. Wft’W *:::Us:: Nf"mmm m:WWW:WWW WWWW WvWWWWW: WWW ::no 01.0.100 191 A ICAI...iaS WWWW ~i a% Ua as m assesa me ’o a aa a a -aS a Ib W . S .5. a. *umu ua~ U MSKS IJ Un OMh bI in i a a U . aaa a a a a a a a * ata5W4PU~af~lfl waS*-f

  7. Research Misconduct—Definitions, Manifestations and Extent

    Directory of Open Access Journals (Sweden)

    Lutz Bornmann


    Full Text Available In recent years, the international scientific community has been rocked by a number of serious cases of research misconduct. In one of these, Woo Suk Hwang, a Korean stem cell researcher published two articles on research with ground-breaking results in Science in 2004 and 2005. Both articles were later revealed to be fakes. This paper provides an overview of what research misconduct is generally understood to be, its manifestations and the extent to which they are thought to exist.

  8. Enhancement of vertebrate cardiogenesis by a lectin from perivitelline fluid of horseshoe crab embryo

    Digital Repository Service at National Institute of Oceanography (India)

    Ghaskadbi, S.; Patwardhan, V.; Chakraborthy, M.; Agrawal, S.; Verma, M.K.; Chatterji, A.; Lenka, N.; Parab, P.B.

    for discussions and suggestions. 19 References 1 Hatada, Y. and Stern, C. D. (1994). A fate map of the epiblast of the early chick embryo. Development 120, 2879-2889. 2 Hamburger, V. and Hamilton, H. L. (1951). A series of normal stages in the development... in the induction of cardiac myogenesis. Genes Dev. 11, 451-462. 9 Streit, A, Lee, K. J., Woo, I., Roberts, C., Jessell, T. M. and Stern, C. D. (1998) Chordin regulates primitive streak development and the stability of induced neural cells...

  9. Characteristics and sources of the electron density irregularities in the mid latitude E and Fregions (United States)


    Investigators (PI and Co-PIs): Young-Sil Kwak (PI), Jaeheung Park , Tae-Yong Yang, Young-Sook Lee, Jong-Min Choi, and Woo Kyoung Lee - e-mail address : yskwak...decoded and integrated raw data signal samples are subjected to the process of fast Fourier transform for on-line computation of the Doppler power... Park , J., H. Luehr, G. Kervalishvili, J. Rauberg, C. Stolle, Y.-S. Kwak, and W. K. Lee (2017), Morphology of high-latitude plasma density

  10. Bangladesh v. India: A Positive Step Forward in Public Order of the Seas (United States)

    2017-09-05 prices -key-to-woo-iocs-35326. 69 “Blocks off Bangladesh draw interest,” Oil & Gas Journal, Oct. 20, 2016, accessed Aug. 24, 2017, http...Arb.2014), p. 163, Top Right: Nandu Chitnis, “ONGC Oil and Gas Processing Platform,” 2009, https...Boundary Commission first established the border between India and Bangladesh (then East Pakistan ). In the early 1970s, a feature (low tide elevation

  11. Using Gagne’s instructional model in phlebotomy education

    Directory of Open Access Journals (Sweden)

    Woo WH


    Full Text Available Wee Hong Woo School of Chemical & Life Sciences, Singapore Polytechnic, Singapore Abstract: As the role of a phlebotomist in a clinical setting involves patient interactions, ­correct patient identification, and blood specimen accessioning, it is essential that the phlebotomy education pay attention to these procedural tasks to inculcate a culture of patient safety. Using the Gagne’s nine events of instruction as the basis of teaching model, this paper describes the lesson plan for teaching the topic of patient approach to a group of phlebotomy students without prior clinical experience. Keywords: venipuncture, Gagne’s model, instructional design, patient handling, Peyton’s steps

  12. Patient-reported outcome and risk of revision after shoulder replacement for osteoarthritis

    DEFF Research Database (Denmark)

    Rasmussen, Jeppe V; Polk, Anne; Brorson, Stig


    PURPOSE: We used patient-reported outcome and risk of revision to compare hemiarthroplasty (HA) with total shoulder arthroplasty (TSA) and stemmed hemiarthroplasty (SHA) with resurfacing hemiarthroplasty (RHA) in patients with glenohumeral osteoarthritis. PATIENTS AND METHODS: We included all...... and 1096 HAs (837 RHAs and 259 SHAs). Patients treated with TSA generally had a better WOOS, exceeding the predefined minimal clinically important difference, at 1 year (mean difference 10, p SHA (mean difference 5, p = 0.02), but the difference did not exceed...

  13. Modeling Graphene Contrast on Copper Surfaces Using Optical Microscopy (United States)


    lattice match with graphene. The high carbon solubility, however, made it difficult to synthesize single monolayers because of surface segregation and...2008;112(22):8192–8195. 18. Ferrari AC, Meyer JC , Scardaci V, Casiraghi C, Lazzeri M, Mauri F, Piscanec S, Jiang D, Novoselov KS, Roth S, Geim AK...2007;45(7):1558–1565. 20. Wang Y, Miao C, Huang B-C, Zhu J, Liu W, Park Y, Xie Y-h, Woo JCS . Scalable synthesis of graphene on patterned Ni and transfer

  14. Advanced Technology for Ultra-Low Power System-on-Chip (SoC) (United States)


    AFRL-RY-WP-TR-2017-0115 ADVANCED TECHNOLOGY FOR ULTRA-LOW POWER SYSTEM-ON-CHIP (SoC) Jason Woo, Weicong Li, and Peng Lu University of California...September 2015 – 31 March 2017 4. TITLE AND SUBTITLE ADVANCED TECHNOLOGY FOR ULTRA-LOW POWER SYSTEM-ON- CHIP (SoC) 5a. CONTRACT NUMBER FA8650-15-1-7574 5b...ABSTRACT The purpose of this advanced study is to provide an analytic framework for silicon on chip (SoC) technology that is based on numerical, simulation

  15. West European and East Asian Perspectives on Defense, Deterrence and Strategy. Volume 6. South Korean Perspectives on Defense, Deterrence and Strategy. (United States)


    Korea’s Foreign Relations," Korea and World Affairs, Summer 1981, pp. 229-242. 66. Jae Seung Woo, "Korea and the United Nations," Korean Journal of...September 1978, pp. 70-77. 96. Scalapino, Robert A., "Current Dynamics of the Korean Peninsula," Problems of Communism, November-December 1981. 97. Seung ...1982. ...-. 4. 140. Yun Hwan Kim, "Economic Dilemma May Sway North Korea," The Korea Herald, June 24, 1981, p. 5. 141. Zagoria, Donald S., "Why We Can’t

  16. In-situ Manipulation and Imaging of Switchable Two-dimensional Electron Gas at Oxide Heterointerfaces (United States)


    should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of...SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT SAR 18. NUMBER OF PAGES    8       19a.  NAME OF RESPONSIBLE PERSON SERNA, MARIO 19b.  TELEPHONE...Nonpolar InGaN/GaN Quantum wells”, Ja Kyung Lee, Kyung Song, Christoph T. Koch, Woo Young Jung , Dmitry Tyutyunnikov, Tiannan Yang, Jong Kyu Kim

  17. The Effects of Dopamine and Estrogen upon Cortical Parvalbumin Expression (United States)


    a home. Thank you to wonderful parents, my mom and dad: Jolyn Resnick and Barry Resnick I have cool in laws, so: Thank you: Dr. Catherine Ricks and...varicosities with GABA neurons of rat medial prefrontal cortex occurs during the postweanling period, Synapse 23 (1996) 237-45. 29 B. Berger, C. Verney, M. Gay ...1982) 512-520. J.N. Pierri, A.S. Chaudry, T- U . Woo an D.A. Lewis, Alterations in chandelier neuron axon terminals in the prefrontal cortex of

  18. Literature in English Language Teaching


    Daskalovska, Nina


    The aim of this book is to show that literature can and should be part of foreign language teaching. It argues that adopting language-based approaches to studying literary texts will help foreign language learners to find the way into the text, to become actively involved in the text, to improve their knowledge of the language, and to develop their literary awareness. The application of language-based approaches is illustrated on three extracts from the novel To the Lighthouse by Virginia Woo...

  19. Severe COPD cases from Korea, Poland, and USA have substantial differences in respiratory symptoms and other respiratory illnesses


    Kim WJ; Yim J; Kim DK; Lee MG; Fuhlbrigge AL; Sliwinski P; Hawrylkiewicz I; Wan ES; Cho MH; Silverman EK


    Woo Jin Kim,1 Jae-Joon Yim,2 Deog Kyeom Kim,3 Myung Goo Lee,4 Anne L Fuhlbrigge,5 Pawel Sliwinski,6 Iwona Hawrylkiewicz,6 Emily S Wan,7,8 Michael H Cho,7,8 Edwin K Silverman7,8 1Department of Internal Medicine and Environmental Health Center, Kangwon National University Hospital, Chuncheon, 2Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Seoul National University College of Medicine, Seoul, 3Department of Internal Medicine, Division of Pulmonary and Critic...

  20. Polymer-Based Materials of Controlled Permeability and Application of Photoinduced Magnetism (United States)


    attention not only for its novel phenomena but more importantly on its 4 possible application in light controlled antennas and detectors and also 02-28-2009) Ohio State University Arthur J. Epstein, PI Jung Woo Yoo, Graduate Student P. Raju Nandyala, Post-Doc Konstantin Pokhodnya...Colorado, March 5-9, 2007 ( BAPS .2007.MAR.J16.13) 10. J.W. Yoo, R. Shima Edelstein, D.M. Lincoln, and A.J. Epstein

  1. Seks ja töö / Andres Maimik

    Index Scriptorium Estoniae

    Maimik, Andres, 1970-


    Filmifestivalil "Armastus ja Anarhia" ("Rakkautta & Anarkiaa") 21.09.- 01.10. nähtud filmidest : Rosa von Praudheimi eluloofilm "Einstein of Sex", Julien Temple dokumentaalfilm "The Filth and the Fury", Virginie Despentes ja Coralie Trinh Thi "Baise moi!" ("Vägista mind!"), Catherine Breillat "Une vraie Jeune Fille" ("Päris noor tüdruk"), Francois Ozoni Rainer Werner Fassbinderi näidendi järgi tehtud film "Gouttes d'eau sur pierres brulantes" ("Veetilgad põlevatel kividel"), Jang Sun Woo "Gojimal" ("Valed") ja Laurent Cantet' "Ressources humaines" ("Inimressursid")

  2. Research ethics and lessons from Hwanggate: what can we learn from the Korean cloning fraud? (United States)

    Saunders, R; Savulescu, J


    In this review of the Korean cloning scandal involving Woo-Suk Hwang, the nature of the disaster is documented and reasons why it occurred are suggested. The general problems it raises for scientific research are highlighted and six possible ways of improving practice are offered in the light of this case: (1) better education of science students; (2) independent monitoring and validation; (3) guidelines for tissue donation for research; (4) fostering of debate about ethically contentious research in science journals; (5) development of an international code of ethical research practice; (6) fostering of public involvement in ethical review and debate through the web.

  3. Pain: A Distributed Brain Information Network? (United States)

    Mano, Hiroaki; Seymour, Ben


    Understanding how pain is processed in the brain has been an enduring puzzle, because there doesn't appear to be a single “pain cortex” that directly codes the subjective perception of pain. An emerging concept is that, instead, pain might emerge from the coordinated activity of an integrated brain network. In support of this view, Woo and colleagues present evidence that distinct brain networks support the subjective changes in pain that result from nociceptive input and self-directed cognitive modulation. This evidence for the sensitivity of distinct neural subsystems to different aspects of pain opens up the way to more formal computational network theories of pain. PMID:25562782

  4. Stem cell research: cloning, therapy and scientific fraud. (United States)

    Rusnak, A J; Chudley, A E


    Stem cell research has generated intense excitement, awareness, and debate. Events in the 2005-2006 saw the rise and fall of a South Korean scientist who had claimed to be the first to clone a human embryonic stem cell line. From celebration of the potential use of stem cells in the treatment of human disease to disciplinary action taken against the disgraced scientists, the drama has unfolded throughout the world media. Prompted by an image of therapeutic cloning presented on a South Korean stamp, a brief review of stem cell research and the events of the Woo-suk Hwang scandal are discussed.

  5. Effect of self-interstitial diffusion anisotropy in electron-irradiated zirconium: A cluster dynamics modeling (United States)

    Christien, F.; Barbu, A.


    A model based on the cluster dynamics approach was proposed in [A. Hardouin Duparc, C. Moingeon, N. Smetniansky-de-Grande, A. Barbu, J. Nucl. Mater. 302 (2002) 143] to describe point defect agglomeration in metals under irradiation. This model is restricted to materials where point defect diffusion is isotropic and is thus not applicable to anisotropic metals such as zirconium. Following the approach proposed by Woo [C.H. Woo, J. Nucl. Mater. 159 (1988) 237], we extended in this work the model to the case where self-interstitial atoms (SIA) diffusion is anisotropic. The model was then applied to the loop microstructure evolution of a zirconium thin foil irradiated with electrons in a high-voltage microscope. First, the inputs were validated by comparing the numerical results with Hellio et al. experimental results [C. Hellio, C.H. de Novion, L. Boulanger, J. Nucl. Mater. 159 (1988) 368]. Further calculations were made to evidence the effect of the thin foil orientation on the dislocation loop microstructure under irradiation. The result is that it is possible to reproduce for certain orientations the 'unexpected' vacancy loop growth experimentally observed in electron-irradiated zirconium [M. Griffiths, M.H. Loretto, R.E. Sallmann, J. Nucl. Mater. 115 (1983) 313; J. Nucl. Mater. 115 (1983) 323; Philos. Mag. A 49 (1984) 613]. This effect is directly linked to SIA diffusion anisotropy.

  6. Validity and sensitivity to change of the Patient Specific Functional Scale used during rehabilitation following proximal humeral fracture. (United States)

    Mannberg Bäckman, Sara; Stråt, Sara; Ahlström, Susanne; Brodin, Nina


    To describe content validity, concurrent validity, sensitivity to change, internal consistency and the outcome distribution of the Patient Specific Functional Scale (PSFS) in patients with proximal humeral fracture. Fifty-three patients with proximal humeral fracture treated conservatively or surgically with plate and screw or intramedullary nail were recruited 6 weeks (±1 week) post-trauma or post-surgery. The following assessments were used: the PSFS, patient global score, shoulder function assessment, grip strength and Western Ontario Osteoarthritis of the shoulder Index (WOOS), before start of (n = 53) and after (n = 22) 2-3 months of group rehabilitation. In total, 96% of the activities stated in the PSFS was classified in the International Classification of Functioning, Disability and Health activity component and 62% were found in the WOOS. Correlations between measures were low. The PSFS was highly sensitive to change to a period of group rehabilitation. All questions of the PSFS contributed to the total score. Both floor and ceiling effects could be noted. The PSFS shows satisfying measurement properties and may be a useful complement in the evaluation of individual changes during a period of rehabilitation after proximal humeral fracture. The PSFS assesses on activity level in patients with proximal humeral fracture. The PSFS is sensitive to change for group rehabilitation after humeral fracture. The PSFS can be useful for goal-setting, motivating and individually tailoring rehabilitation activities. The PSFS should be used in addition to specific measures of body functions and general health.

  7. Object relations perspectives on "Phantom of the Opera" and its demon lover theme: the modern film. (United States)

    Kavaler-Adler, Susan


    This study of the modern film version of "Phantom of the Opera" employs a mythic theme to illustrate how women can involve themselves with charismatic and eroticized narcissistic men, who are unavailable for true relationship within the conscious world of societal connection. How can the healthy-heroic woman extricate herself from the seductive web of such men, men who seek to own the women--not through sexual relations--but through ownership and control of the women's creative talents? What are the developmental, internal world, dynamics that spell out the muse turned demon/lover theme in British and American Object Relations terms? Similar to the mythic vampire who entrances women to suck their blood, the male muse haunts the female artist to possess her talents. The "demon lover" creates himself to woo the unsuspecting female with potential but yet unrealized creative talents. He woos through entrancement, like so many psychologically wounded narcissistic characters who require mirroring to have any sense of existence!

  8. Estimates of population parameters and consumption/biomass ratio for fishes in reservoirs, Paraná State, Brazil

    Directory of Open Access Journals (Sweden)

    Éder André Gubiani

    Full Text Available Consumption, natural mortality, and growth are important parameters for the construction for both fisheries and ecosystems models. We estimated k (growth constant of the von Bertalanffy's function, Loo 1(asymptotic length, Woo (asymptotic weight, Ar (caudal fin index, M (natural mortality, and Q/B (consumption/biomass ratio for several fish species inhabiting reservoirs. We explored possible relationships among these parameters for 135 fish species sampled in thirty reservoirs in the State of Paraná, southern Brazil. Maximum length (Lmax varied from 2.60 to 79.00 cm, Loo from 2.73 to 85.05 cm, Woo from 0.23 to 9,490.26 g, k from 0.01 to 2.38 yr-1, Ar from 0.03 to 3.60, M from 0.16 to 2.82 yr-1, and Q/B from 3.31 to 67.18. Significant correlations were observed between most pairs of parameters, except for Ar and k, Ar and Loo , and for M and Q/B. The estimates presented here may be useful for constructing Ecopath models, both in Brazil and other tropical regions, where the use of ecosystem modeling is growing.

  9. Web-of-Objects (WoO-Based Context Aware Emergency Fire Management Systems for the Internet of Things

    Directory of Open Access Journals (Sweden)

    Zia Ush Shamszaman


    Full Text Available Recent advancements in the Internet of Things (IoT and the Web of Things (WoT accompany a smart life where real world objects, including sensing devices, are interconnected with each other. The Web representation of smart objects empowers innovative applications and services for various domains. To accelerate this approach, Web of Objects (WoO focuses on the implementation aspects of bringing the assorted real world objects to the Web applications. In this paper; we propose an emergency fire management system in the WoO infrastructure. Consequently, we integrate the formation and management of Virtual Objects (ViO which are derived from real world physical objects and are virtually connected with each other into the semantic ontology model. The charm of using the semantic ontology is that it allows information reusability, extensibility and interoperability, which enable ViOs to uphold orchestration, federation, collaboration and harmonization. Our system is context aware, as it receives contextual environmental information from distributed sensors and detects emergency situations. To handle a fire emergency, we present a decision support tool for the emergency fire management team. The previous fire incident log is the basis of the decision support system. A log repository collects all the emergency fire incident logs from ViOs and stores them in a repository.

  10. Synthesis of 9- and 27-armed tetrakis(diperoxotungsto)phosphate-cored dendrimers and their use as recoverable and reusable catalysts in the oxidation of alkenes, sulfides, and alcohols with hydrogen Peroxide. (United States)

    Nlate, Sylvain; Plault, Lauriane; Astruc, Didier


    A series of 3- and 9-armed dendrons, functionalized at the focal position to quaternary ammonium salts, were synthesized and characterized. The reaction of these ammonium dendrons with the heteropolyacid H(3)PW(12)O(40) in the presence of hydrogen peroxide led to a family of 9- and 27-armed air-stable polyoxometalate (POM)-cored dendrimers containing a catalytically active trianionic POM species [PO(4)[WO(O(2))(2)](4)](3-) in the core. These POM-cored dendrimers are air-stable, efficient, recoverable, and reusable catalysts for the selective oxidation of alkenes to epoxides, sulfides to sulfones, and alcohols to ketones, in an aqueous/CDCl(3) biphasic system with hydrogen peroxide as the primary oxidant. A study of the countercation effects showed that the dendritic structure increased the stability of the POM species and facilitated the recovery of the catalyst up to the eighth cycle, whereas the increased bulkiness around the POM center led to a negative kinetic dendritic effect. Within the 9-armed POM-cored dendrimer series, the reaction kinetics were susceptible to the nature of the peripheral endgroups. Indeed, the 9-armed n-propyl-terminated POM-cored dendrimer was identified as the most active catalyst. In addition, the results obtained with POM-cored dendrimers versus tetraalkylammonium POMs ([[n-(C(8)H(17))(3)NCH(3)](+)](3)[PO(4)[WO(O(2))(2)](4)](3-) and [[nC(18)H(37)(75 %) + nC(16)H(33)(25 %)](2)N(CH(3))(2)](+)](3)[PO(4)[WO(O(2))(2)](4)](3-)) clearly reveal that the dendritic structures are more stable than their nondendritic counterparts. After the reactions were complete, the dendrimer catalysts were easily recovered and recycled without a discernable lost of activity, whereas attempts to recover tetraalkylammonium POMs gave unsatisfactory results. A significant advantage of the dendritic structures is that they enable the recovery and recyclability of the POM catalyst, in contrast to the other tetraalkylammonium POMs.

  11. Of money and trust in medical care redux. (United States)

    Lexchin, Joel


    Should we be concerned about financial conflicts of interest (COI) between doctors and the pharmaceutical industry? Some people will say no as there are clearly doctors who celebrate the relationship. Others say that it does not matter to patients, but the evidence says otherwise. Financial COI is different from other types of conflicts because it is voluntary and can be refused. Finally, it is not just the large gifts that are a problem, the small ones also create a "gift relationship." Drug companies know about this and spend billions on promotion with good effect from their point of view. Companies also woo doctors who honestly hold pro-industry points of view to speak on behalf of the companies. There are still multiple examples of financial COI, and although there are isolated examples of improvement, this is still an area of deep concern.

  12. Schepping en Evolutie*

    Directory of Open Access Journals (Sweden)

    J. Lever


    Full Text Available De lieide woorclen die in de titel van deze voordracht naast elkander staan liehben voor de Christen relaties tot twee verscliillende sferen van liet mens-zijn. Het woord „schepping” belioort tot de sfeer van het relifiieuze geloven, daar het ons in beslag neemt vanuit de Goddelijke openbaring in de Bijbel. Het wooTd „evolutie” daarentegen, komt uit de sfeer van de menselijke ervaring via het wetenschappelijk onderzoek, dat het worden van de wereld waarvan wij deal uitmaken zo veel mogelijk tracht te kennen en te legrijpen. Het bijeenvoegen van deze twee woorden in de titel wijst er dus reeds op dat, hoewel in deze voordracht een meer toegespitst vraagstuk behandeld wordt, dit slechts kan geschieden tegen de aclitergrond van de algemene vraagstukken van „Bijbel en wetenschap’’, en „geloof en wetenschap”. Wij rullen in het navolgende geleidelijk deze problematiek benaderen.

  13. For love or money? The saga of Korean women who provided eggs for embryonic stem cell research. (United States)

    Baylis, Françoise


    In 2004 and 2005, Woo-Suk Hwang achieved international stardom with publications in Science reporting on successful research involving the creation of stem cells from cloned human embryos. The wonder and success all began to unravel, however, when serious ethical concerns were raised about the source of the eggs for this research. When the egg scandal had completely unfolded, it turned out that many of the women who provided eggs for stem cell research had not provided valid consents and that nearly 75% of the women egg providers had received cash or in-kind payments. Among those who did not receive direct benefits, some cited patriotism as their reason for participating in embryonic stem cell research, hence the question "for love or money?"--namely, patriotism versus payment. This paper summarizes the Hwang debacle with particular attention to the egg scandal and ends with some preliminary thoughts on patriotism as a motive for research participation.

  14. The general equilibrium theory as economic metatheory

    Directory of Open Access Journals (Sweden)



    Full Text Available Many economists show certain nonconformity relative to the excessive mathematical formalization of economics. This stems from dissatisfaction with the old debate about the lack of correspondence between mainstream theoretical models and reality. Although we do not propose to settle this debate here, this article seeks to associate the mismatch of mathematized models with the reality of the adoption of the hypothetical-deductive method as reproduced by general equilibrium. We begin by defining the main benefits of the mathematization of economics. Secondly, we address traditional criticism leveled against it. We then focus on more recent criticism from Gillies (2005 and Bresser-Pereira (2008. Finally, we attempt to associate the reproduction of the hypothetical-deductive method with a metatheoretical process triggered by Debreu's general equilibrium theory. In this respect, we appropriate the ideas of Weintraub (2002, Punzo (1991, and mainly Woo (1986 to support our hypothesis.

  15. Trypanosoma vivax infection dynamics in a cattle herd maintained in a transition area between Pantanal lowlands and highlands of Mato Grosso do Sul, Brazil Dinâmica de infecção de Trypanosoma vivax em rebanho bovino mantido numa área de transição entre o Pantanal e o planalto de Mato Grosso do Sul

    Directory of Open Access Journals (Sweden)

    Charles F. Martins


    Full Text Available Trypanosoma vivax outbreaks in beef cattle in the Pantanal region of Mato Grosso do Sul state, Brazil, causes relevant economical impact due to weight loss, abortion and mortality. Cattle moved from the Pantanal to adjacent areas of this ecosystem for breeding and fattening is a common feature. Therefore an epidemiological study on breeding cows in the transition area between Pantanal lowland and adjacent highlands of Mato Grosso do Sul was performed to determine the T. vivax infection dynamics and outbreak risk. Three experimental groups were formed: Group 1 consisted of cows parasitologically negative by the Woo test and in the enzyme-linked immunosorbent assay for T. vivax antibody detection (Tv-ELISA-Ab; Group 2 parasitologically negative and positive in the Tv-ELISA-Ab; and in Group 3 cows were parasitologically positive and with positive reactions in the Tv-ELISA-Ab. During 24 months, the cows' dislodgment between the above established groups was monitored by Woo test and Tv-ELISA-Ab exams. The tabanid population was also monitored and the highest number occurred during the rainy season. Although parasitemias were detected only in the first four samplings of the experimental period, the cows could be considered as trypanotolerant, because no clinical signs were observed. Despite the higher T. vivax incidence during the dry season, no disease symptoms were seen. Even though T. vivax epidemiological situation in the herd was characterized as endemic with seasonal variation, the probability of outbreaks was null within the conditions of the study.Surtos de Trypanosoma vivax em bovinos de corte do Pantanal foram responsáveis por relevante impacto econômico, devido a perda de peso, abortos e mortalidade. Um manejo comum é o deslocamento de bovinos do Pantanal baixo para áreas adjacentes desse ecosistema para reprodução e engorda. Por essa razão, foi efetuado um estudo epidemiológico em rebanho de vacas movidas para uma área de transi

  16. Testing geopressured geothermal reservoirs in existing wells. Annual report

    Energy Technology Data Exchange (ETDEWEB)


    This contract called for the acquisition and testing of Wells of Opportunity. Wells of Opportunity are located by screening published information on oil industry activity and through personal contacts with oil operators. This process resulted in recommendation of 21 candidate wells to the DOE for the WOO program. Of the 21 wells recommended, 7 were accepted. Six of these 7 were acquired for testing. Three wells have been tested, and the fourth and fifth will be tested early in 1981. Preliminary test results are briefly described and are shown in a table. The actual testing schedule and the originally proposed schedule matched very closely. Cumulative costs through November 1980 were approximately $6.5 million and compare to an estimate of $8.5 million for the same period. A graphical comparison of actual versus estimated costs is given.

  17. The modular sequence space of $\\chi^{2}$

    Directory of Open Access Journals (Sweden)

    N. Subramanian


    Full Text Available In this paper we introduce the modular sequence space of $\\chi^{2}$ and examine some topological properties of these space also establish some duals results among them. Lindenstrauss and Tzafriri [7] used the idea of Orlicz function to define the sequence space $\\ell_{M}$ which is called an Orlicz sequence space. Another generalization of Orlicz sequence spaces is due to Woo [9]. We define the sequence spaces $\\chi^{2}_{f\\lambda}$ and $\\chi^{2\\lambda}_{g},$ where $f=\\left(f_{mn}\\right$ and $g=\\left(g_{mn}\\right$ are sequences of modulus functions such that $f_{mn}$ and $g_{mn}$ be mutually complementary for each $m,n.$

  18. Shock wave science and technology reference library

    CERN Document Server


    This book is the second of several volumes on solids in the Shock Wave Science and Technology Reference Library. These volumes are primarily concerned with high-pressure shock waves in solid media, including detonation and high-velocity impact and penetration events. Of the four extensive chapters in this volume, the first two describe the reactive behavior of condensed phase explosives, - Condensed-Phase Explosives: Shock Initiation and Detonation Phenomena (SA Sheffield and R Engelke) - First Principles Molecular Simulations of Energetic Materials at High-Pressures (F Zhang, S Alavi, and TK Woo), and the remaining two discuss the inert, mechanical response of solid materials. - Combined Compression and Shear Plane Waves (ZP Tang and JB Aidun), and - Dynamic Fragmentation of Solids (D Grady). All chapters are each self-contained, and can be read independently of each other. They offer a timely reference, for beginners as well as professional scientists and engineers, on the foundations of detonation phenomen...

  19. The Atacama Cosmology Telescope: The Receiver and Instrumentation (United States)

    Swetz, D. S.; Ade, P. A. R.; Amiri, M.; Appel, J. W.; Burger, B.; Devlin, M. J.; Dicker, S. R.; Doriese, W. B.; Essinger-Hileman, T.; Fisher, R. P.; hide


    The Atacama Cosmology Telescope was designed to measure small-scale anisotropies in the Cosmic Microwave Background and detect galaxy clusters through the Sunyaev-Zel'dovich effect. The instrument is located on Cerro Taco in the Atacama Desert, at an altitude of 5190 meters. A off-axis Gregorian telescope feeds a new type of cryogenic receiver, the Millimeter Bolometer Array Camera. The receiver features three WOO-element arrays of transition-edge sensor bolometers for observations at 148 GHz, 218 GHz, and 277 GHz. Each detector array is fed by free space mm-wave optics. Each frequency band has a field of view of approximately 22' x 26'. The telescope was commissioned in 2007 and has completed its third year of operations. We discuss the major components of the telescope, camera, and related systems, and summarize the instrument performance.

  20. Revision of Eucorydia Hebard, 1929 from China, with notes on the genus and species worldwide (Blattodea, Corydioidea, Corydiidae

    Directory of Open Access Journals (Sweden)

    Lu Qiu


    Full Text Available The cockroach genus Eucorydia from China is revised. Five new species are described and illustrated: Eucorydia linglong sp. n., Eucorydia pilosa sp. n., Eucorydia splendida sp. n., Eucorydia guilinensis sp. n., and Eucorydia tangi sp. n.. Corydia purpuralis Kirby, 1903 and Eucorydia paucipilosa Woo, Guo & Feng, 1986 are confirmed to be junior synonyms of Eucorydia dasytoides (Walker, 1868. Eucorydia hilaris (Kirby, 1903 is newly recorded from China. This genus and currently known species from around the world are discussed. The status of Eucorydia maxwelli (Hanitsch, 1915 is revived. Corydia plagiata Walker, 1868 is confirmed to be a junior synonym of Eucorydia ornata (Saussure, 1864. A checklist, key, and photographs of members of this genus are provided.

  1. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 19. (Tube Manufacturing Co., Inc.-Voith-Turbo GMBH & Co. KG) (United States)


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  2. Uncertainty propagation analysis applied to volcanic ash dispersal at Mt. Etna by using a Lagrangian model (United States)

    de'Michieli Vitturi, Mattia; Pardini, Federica; Spanu, Antonio; Neri, Augusto; Vittoria Salvetti, Maria


    variance of the grain size distribution at various distances from the source, both in air and on the ground. In particular, results highlighted the strong reduction of the uncertainty ranges of the mean and variance of the grain-size distribution with increasing distance from source and the significant control of particle sphericity on the dispersal process. References M de'Michieli Vitturi, A Neri, T Esposti Ongaro, S Lo Savio, and E Boschi. Lagrangian modeling of large volcanic particles: Application to Vulcanian explosions. Journal of Geophysical Research: Solid Earth (1978-2012), 115(B8), 2010.

  3. Economic cycles and their synchronization: Spectral analysis of macroeconomic series from Italy, The Netherlands, and the UK (United States)

    Sella, Lisa; Vivaldo, Gianna; Ghil, Michael; Groth, Andreas


    economy of a country: Hallegatte and Ghil (Ecol. Econ., 2008) have shown that the presence of business cycles modifies substantially this impact with respect to their impact on an economy in or near equilibrium. The present work concludes with a study of the synchronization of economic fluctuations, which follows a similar study of macroeconomic indicators for the United States, presented in a nearby poster. Since business cycles are not country-specific phenomena, but show common characteristics across countries, our aim is to uncover hidden global behavior across the European economies (cf. Mazzi and Savio, Macmillan, 2006).

  4. Different formulas, different thresholds and different performance-the prediction of macrosomia by ultrasound. (United States)

    Aviram, A; Yogev, Y; Ashwal, E; Hiersch, L; Danon, D; Hadar, E; Gabbay-Benziv, R


    The sonographic prediction of fetal macrosomia affects obstetrical decision regarding the timing and mode of delivery. We aimed to compare the accuracy of various formulas for prediction of macrosomia at different thresholds. This was a retrospective cohort study of singleton gestations at term, with fetal biometrical measurements taken up to 7 days prior to delivery (2007 to 2014). Sonographic estimated fetal weight was calculated using 20 previously published formulas. Macrosomia prediction was evaluated for every formula utilizing: (1) measures of accuracy (sensitivity, specificity and so on); (2) comparison of the systematic and random errors (SE and RE), and the proportion of estimates within 10% of actual birth weight for macrosomic and non-macrosomic neonates. Performance measurements were evaluated for different macrosomia thresholds: 4000, 4250 and 4500 g. Best performing formula for every threshold was defined as the one with the lowest Euclidean distance (=SQRT(SE 2 +RE 2 )). Out of 7977 women who met the inclusion criteria, 754 (9.4%) delivered a neonate weighing ⩾4000 g, 266 (3.3%) delivered a neonate weighing⩾4250 g and 75 (0.9%) delivered a neonate weighing⩾4500 g. Considerable variability was noted between the accuracy parameters of the different formulas, with Woo's formula integrating Abdominal circumference (AC) and femur length (FL) as the most sensitive formula with the highest negative predictive value for all thresholds and Woo's formula using AC, FL and biparietal diameter (BPD) as the most specific for all thresholds. The same formula also demonstrated the best overall accuracy. Regardless of threshold chosen, 80% or more of formulas demonstrated negative systematic error, meaning lower EFW than actual birthweight. As for the Euclidean distance, Hadlock's formula (AC, FL and BPD) ranked the highest for the 4000 and 4250 g thresholds, whereas Shepard's formula (AC and BPD) ranked the highest for the 4500 g threshold

  5. Exposure–outcome analysis in depressed patients treated with paroxetine using population pharmacokinetics

    Directory of Open Access Journals (Sweden)

    Kim JR


    Full Text Available Jung-Ryul Kim,1 Hye In Woo,2 Mi-Ryung Chun,3 Shinn-Won Lim,4 Hae Deun Kim,5 Han Sung Na,5 Myeon Woo Chung,5 Woojae Myung,6 Soo-Youn Lee,1,3 Doh Kwan Kim6 1Department of Clinical Pharmacology and Therapeutics, Samsung Medical Center, Seoul, 2Department of Laboratory Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, 3Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 4Samsung Advanced Institute for Health Sciences and Technology (SAIHST, Sungkyunkwan University, Seoul, 5Clinical Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, Chungcheongbuk-do, 6Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea Purpose: This study investigated population pharmacokinetics of paroxetine, and then performed an integrated analysis of exposure and clinical outcome using population pharmacokinetic parameter estimates in depressed patients treated with paroxetine. Patients and methods: A total of 271 therapeutic drug monitoring (TDM data were retrospectively collected from 127 psychiatric outpatients. A population nonlinear mixed-effects modeling approach was used to describe serum concentrations of paroxetine. For 83 patients with major depressive disorder, the treatment response rate and the incidence of adverse drug reaction (ADR were characterized by logistic regression using daily dose or area under the concentration–time curve (AUC estimated from the final model as a potential exposure predictor. Results: One compartment model was developed. The apparent clearance of paroxetine was affected by age as well as daily dose administered at steady-state. Overall treatment response rate was 72%, and the incidence of ADR was 30%. The logistic regression showed that exposure

  6. Production and characterization of polyclonal and monoclonal Abs against the RNA-binding protein QKI. (United States)

    Zhang, Jie; Huang, Bo; Yu, Fang; Wei, Mengying; Yang, Guodong; Fu, Haiyan; Jin, Liang; Bai, Liyuan; He, Xianli; Lu, Zifan


    RNA-binding protein QKI, a member of the Signal Transduction and Activation of RNA family, is found to be essential in the blood vessel development and postnatal myelination in central nervous system (Woo et al., Oncogene 28:1176-1186, 2009; Lu et al., Nucleic Acids Res 31(15):4616-4624, 2003; Bohnsack et al., Genesis 44(2):93-104, 2006). However, its wide expression pattern suggests other fundamental roles in vivo (Kondo et al., Mamm Genome 10(7):662-669, 1999). To facilitate the understanding of QKI function in various systems, we prepared the polyclonal and monoclonal antibodies against QKI. To obtain the antigen, recombinant His-tagged QKI was expressed in Escherichia coli and highly purified by Ni(2+)-chelated column combined with hydrophobic and ion exchange methods. Following three types of immunizations with different adjuvants, including Freund's, PAGE gel, and nitrocellulose membrane, only the antiserum produced with Freund's adjuvant is effective for Western blot detection. Several McAb clones are able to recognize both endogenous and over-expressed QKI with high affinity in Western blot and immunofluorescence. The specificity of Ab was validated as weakening, and no specific signals were observed in cells with QKI knocking down. Immunohistochemistry analysis further showed positive staining of QKI in kidney where QKI mRNA was abundantly expressed, ensuring the wide applications of the QKI Abs in the ongoing mechanistic studies.

  7. Unveiling changes in the landscape of patient populations in cancer early drug development (United States)

    Hierro, Cinta; Azaro, Analía; Argilés, Guillem; Elez, Elena; Gómez, Patricia; Carles, Joan; Rodon, Jordi


    The introduction of new Molecularly Targeted Agents (MTA) has changed the landscape in Early Drug Development (EDD) over the last two decades, leading to an improvement in clinical trial design. Previous Phase 1 (Ph1) studies with cytotoxics focused on safety objectives, only recruiting heavily pre-treated cancer patients, have been left behind. In this review, we will illustrate the slow although unstoppable change that has increasingly been observed in those populations candidate to participate in EDD trials with the advent of MTA. As more evidence regarding oncogene addiction becomes available, molecular-biomarker driven selection has been implemented among Molecularly-Selected Population (MSP) studies. New Window-Of-Opportunity (WOO) and Phase 0 (Ph0) studies have been developed in order to assess whether a MTA produces the hypothetical proposed biological effect. The rising need of getting early pharmacokinetics and pharmacodynamics data has led to the conduction of Healthy Volunteer (HV) studies, in part favoured for the particular and different toxicity profile of these MTA. However, several challenges will need to be addressed in order to boost the implementation of these new clinical trial designs in the forthcoming years. Among the problems to overcome, we would highlight a better coordination effort between centers for ensuring adequate patient accrual among small patient populations and a deepening into the ethics implied in enrolling patients in studies with no therapeutic intent. However, these tribulations will be certainly compensated by the possibility of opening a new horizon of treatment for diseases with dismal prognosis. PMID:27835915

  8. [Fraudulent publication in medical journals]. (United States)

    Becerril-Ángeles, Martín; García-Gómez, Francisco


    Fraud can be present in some scientific medical publications; however, the magnitude of this situation is unknown. One of the associated factors for this transgression of the good practice of investigation is the need to publish and obtain recognition and benefits, regardless of the means. The deliberate fabrication and falsification of data, plagiarism and duplication of publications are some of the scientific misconducts. Many cases of fraud in publications are known, and they have reached public opinion and have been a matter of legal sanctions (the names of Woo Suk Hwang, Jon Sudbo, Joachim Blodt, Robert Slutsky, and William Summerlin reminds us a few known cases). In the last decades, national and international regulatory organisms have been created in order to intervene against this scientific misconduct. Currently, we can rely on several effective software programs, whose function is to detect plagiarism and falsification of data. The prevention of scientific misconduct through information and education of the investigators could lead to the decrease of the presence of this problem, which damages scientific credibility and put at risk the patient's safety.

  9. The prevalence of Microfilaria spp. in primates of colombian zoos

    Directory of Open Access Journals (Sweden)

    Rosmery Ladino De La Hortúa


    Full Text Available The prevalence of Microfilaria spp in 266 human and non human primates of Colombian zoos located between 5 and 2850 meters over sea level (mosl was of 6.39% (17/266. Most of them were adult males Saguinus leucopus, Saguinus oedipus, Saimiri sciureus and Aotus sp; corresponding to Matecaña, Santa Fe and Santacruz zoos, located between 1.001-2.000 mosl. The microfilarias species observed in this study are morphologically compatible with Dipetalonema perstans and Microfilaria bolivarensis, using direct drop technique, Woo, extended of central blood and capillary dyed with Giemsa and Knott, The most sensible technique was extended of central blood dyed with Giemsa. The statistical program used was Epi info 6.1, to determinate prevalence by sex, age, species, zoo, technique and altitude, with a significance level of (P = 0.05. The Saguinus leucopus showed high quantities of microfilaremias with sickness signs, so they were considered reservoirs and / or porter of the microfilarias.

  10. Development of a chitosan based double layer-coated tablet as a platform for colon-specific drug delivery

    Directory of Open Access Journals (Sweden)

    Kim MS


    Full Text Available Min Soo Kim,1,* Dong Woo Yeom,1,* Sung Rae Kim,1 Ho Yub Yoon,1 Chang Hyun Kim,1 Ho Yong Son,1 Jin Han Kim,1 Sangkil Lee,2 Young Wook Choi1 1College of Pharmacy, Chung-Ang University, Seoul, 2College of Pharmacy, Keimyung University, Daegu, South Korea *These authors contributed equally to this work Abstract: A double layer-coated colon-specific drug delivery system (DL-CDDS was developed, which consisted of chitosan (CTN based polymeric subcoating of the core tablet containing citric acid for microclimate acidification, followed by an enteric coating. The polymeric composition ratio of Eudragit E100 and ethyl cellulose and amount of subcoating were optimized using a two-level factorial design method. Drug-release characteristics in terms of dissolution efficiency and controlled-release duration were evaluated in various dissolution media, such as simulated colonic fluid in the presence or absence of CTNase. Microflora activation and a stepwise mechanism for drug release were postulated. Consequently, the optimized DL-CDDS showed drug release in a controlled manner by inhibiting drug release in the stomach and intestine, but releasing the drug gradually in the colon (approximately 40% at 10 hours and 92% at 24 hours in CTNase-supplemented simulated colonic fluid, indicating its feasibility as a novel platform for CDD. Keywords: chitosan, colon-specific delivery, acidification, microflora, factorial design, controlled release

  11. The Effect of Hominis Placenta Herbal Acupuncture on Bell's palsy

    Directory of Open Access Journals (Sweden)

    Yun Jeong-hun


    Full Text Available This report was done to observe the effect of Hominis placenta herbal acupuncture on Bell's palsy. The study group comprised 16 patients who arrived at Woo-suk university oriental hospital from January, 1999 till January, 2000 for Bell's palsy. All patients were divided into two group. One was herbal acupunture group, and the other was control group. Acupunture group was done herbal acupuncture therapy on the facial acupuncture points. Followings are achievement and a term of each group. In herbal acupuncture group, 100% motor recovery was 7 case, 75% was 1 case, and 25% motor recovery term was 7.38±5.21 days, 50% was 11.00±6.16 days, 75% was 15.13±9.55 days, 100% was 23.14±7.97 days. In control group, 100% motor recovery was 4 case, 75% was 2 case, 25% below was 2 case and 25% motor recovery term was 11.17±4.96days, 50% was 18.17±6.82 days, 75% was 29.50±6.95 days, 100% was 44.00±11.49 days. The above results indicate that Hominis placenta herbal acupuncture is a useful effect on Bell's palsy. thus, continuous herbal acupunture study will be needed for more clinical application on Bell' palsy.

  12. Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites

    KAUST Repository

    Woo, Yong


    The eukaryotic phylum Apicomplexa encompasses thousands of obligate intracellular parasites of humans and animals with immense socio-economic and health impacts. We sequenced nuclear genomes of Chromera velia and Vitrella brassicaformis, free-living non-parasitic photosynthetic algae closely related to apicomplexans. Proteins from key metabolic pathways and from the endomembrane trafficking systems associated with a free-living lifestyle have been progressively and non-randomly lost during adaptation to parasitism. The free-living ancestor contained a broad repertoire of genes many of which were repurposed for parasitic processes, such as extracellular proteins, components of a motility apparatus, and DNA- and RNA-binding protein families. Based on transcriptome analyses across 36 environmental conditions, Chromera orthologs of apicomplexan invasion-related motility genes were co-regulated with genes encoding the flagellar apparatus, supporting the functional contribution of flagella to the evolution of invasion machinery. This study provides insights into how obligate parasites with diverse life strategies arose from a once free-living phototrophic marine alga. © Woo et al.

  13. Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Dolton Illinois - Vanlear Kentucky) (United States)


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  14. Genealogy of the "Green Revolution" gene in rice. (United States)

    Nagano, Hironori; Onishi, Kazumitsu; Ogasawara, Mitsuhiro; Horiuchi, Yuki; Sano, Yoshio


    During the "Green Revolution" of rice, high-yielding varieties (HYVs) were developed using a semi-dwarf gene (sd1 or OsGA20ox2). The presence or absence of the two mutant alleles (DGWG type in Dee-geo-woo-gen and JKK type in Jikkoku) were surveyed by PCR using 256 accessions of eight wild and two cultivate rice species. The DGWG allele was detected in a landrace (Oryza sativa) and two accessions of wild rice (O. rufipogon), all of which are from China, showing their limited distribution. Genealogical studies of the OsGA20ox2 gene showed that the 62 sequences of O. sativa and O. rufipogon included 20 distinct haplotypes, indicating that the species complex contained OsGA20ox2 genes from two different lineages. The silent site nucleotide diversities (pi and theta(w)) were extremely low in Japonica rice, suggesting a genetic bottleneck. The haplotype network showed that the DGWG and JKK alleles were derived in different lineages. The DGWG carrier (W1944) had unique polymorphisms in the surrounding region of the locus, suggesting that the DGWG allele has been preserved in the wild progenitor, rather than that the DGWG allele has been introgressed from HYVs to W1944. Although a semi-dwarfing plant is a weak competitor under saturated fields, the crossing experiment revealed that the DGWG variant might have been preserved as a hidden variation in the genetic background of wild rice, without expressing a short-stature.

  15. Study of the combined effect of temperature, pH and water activity on the radial growth rate of the white-rot basidiomycete Physisporinus vitreus by using a hyphal growth model

    CERN Document Server

    Fuhr, M J; Schubert, M; Schwarze, F W M R; Herrmann, H J


    The present work investigates environmental effects on the growth of fungal colonies of P. vitreus by using a lattice-free discrete modelling approach called FGM (Fuhr et al. (2010), arXiv:1101.1747), in which hyphae and nutrients are considered as discrete structures. A discrete modelling approach allows studying the underlying mechanistic rule concerning the basic architecture and dynamic of fungal networks on the scale of a single colony. By comparing simulations of the FGM with laboratory experiments of growing fungal colonies on malt extract agar we show that combined effect of temperature, pH and water activity on the radial growth rate of a fungal colony on a macroscopic scale may be explained by a power law for the growth costs of hyphal expansion on a microscopic scale. The information about the response of the fungal mycelium on a microscopic scale to environmental conditions is essential to simulate its behavior in complex structure substrates such as wood, where the impact of the fungus to the woo...

  16. The Subtitling of Indigenous Values in the Film Seediq Bale

    Directory of Open Access Journals (Sweden)

    Tzu-yi Elaine Lee


    Full Text Available The movie Seediq Bale, directed by Wei Te-Sheng and produced by John Woo, is a Taiwanese historical drama epic film based on the Wushe Incident in 1930. The story depicts the Wushe Incident, which happened in central Taiwan while it was under Japanese rule. Mona Rudao, a then chief of Seediq indigenous village Mahebu, led warriors against Japanese authorities due to the long-term colonial oppression. In response, the Japanese mounted a relentless counter-attack, killing over three hundred Seediq people. Often compared by the media in Taiwan to the films Braveheart and The Last of the Mohicans, the film, released in 2011, is so far the most expensive production in Taiwan cinema history. Different language registers are present in the movie, including Mandarin, Japanese, and the Seediq language; this can be a great challenge for the translator when translating the subtitles into English. Nonetheless, it is believed that ideologies can be manifested in language use. So, the study attempts to disclose the translator¡¦s hidden indigenous ideologies in the English subtitles s/he provided. Moreover, as subtitling translation involves a multiplicity of verbal and non-verbal semiotic modes, those visual and audio elements could also contribute to the final product of subtitle translations. Hence, the study, in addition to the translator¡¦s indigenous ideologies and handling of ethnic issues in translation, also looks at how the translator worked with semiotic modes in designing the subtitles for the target context.

  17. Description of Pseudorhabdosynochus seabassi sp. n. (Monogenea: Diplectanidae) from Lates calcarifer and revision of the phylogenetic position of Diplectanum grouperi (Monogenea: Diplectanidae) based on rDNA sequence data. (United States)

    Wu, Xiang Y; Li, An X; Zhu, Xing Q; Xie, Ming Q


    Pseudorhabdosynochus seabassi sp. n. (Monogenea: Diplectanidae) from the gill filaments of Lates calcarifer Bloch, a marine teleost fish held in floating sea cages in Guangdong Province, China, is described based on morphological observations and molecular data. The shapes of the male copulatory organs (MCO) of Pseudorhabdosynochus spp. were the focus of this study. The typical proximal part of the MCO in most species of Pseudorhabdosynochus is reniform, heavily sclerotized, and divided into four chambers. However, the new species from L. calcarifer has a bulbous proximal region with four concentric layers of apparent muscular origin, instead of a reniform structure with four compartments. This organ is also different in Diplectanum grouperi Bu, Leong, Wong, Woo et Foo, 1999, being sclerotized, cup-shaped, wide proximally with four concentric muscular layers and tubular distally. The 3' terminal portion of the small subunit ribosomal RNA gene (ssrDNA) and the 5' terminal region (domains C1-D2) of the large subunit ribosomal RNA gene (lsrDNA) were used to reconstruct the phylogenetic relationships of P. seabassi and D. grouperi with related taxa utilizing maximum-parsimony and neighbour-joining methods. Phylogenetic analyses unequivocally placed D. grouperi amongst Pseudorhabdosynochus using either ssrDNA or lsrDNA data. All species of Pseudorhabdosynochus (including D. grouperi) used in this study clustered together, inferring monophyly. Based on molecular phylogenetic evidence, we propose that D. grouperi from Epinephelus coioides Hamilton be transferred to Pseudorhabdosynochus as P. grouperi comb. n.

  18. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 5. Conti Corporation-Donley-Bundy & Associates. (United States)


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  19. Russian and Chinese Policies of Soft Power in the Central Asia (the Case of Kazakhstan

    Directory of Open Access Journals (Sweden)

    Guangzhen Wang


    Full Text Available The policy of “soft power” has lost some of its power in the Russian foreign policy, but continues to dominate in the minds of researchers. There are a lot of scientific and journalistic articles on this subject. The notion has already become a kind of trend, not only in the field of international relations and in the field of political science. The key criterion for determining the impact of “soft power” is “attraction”, that is how the subject can woo the object in order to have some influence on it. Both Russia and China have a set of instruments of “soft power”, which in varying degrees, allow them to influence the objects, including the countries of Central Asia, especially Kazakhstan. Due to the fact that the KR unofficially became the leader of the region, its example can be most clearly trace the desire of Russia and China to become the most attractive partner for Kazakhstan. The study is based on the Comparative Approach, which allows not only to identify the characteristics of the “soft power” of Russia and China, but to compare their effectiveness. The activities of the two countries is analyzed through the prism of tools used in the region of “soft power”, including investment, educational, scientific and cultural programs.


    Directory of Open Access Journals (Sweden)

    K. V. Dobrego


    Full Text Available Modern Cooling Towers (CT may utilize different aerodynamic elements (deflectors, windbreak walls etc. aimed to improvement of its heat performance especially at the windy conditions. In this paper the effect of flow rotation in overshower zone of CT and windbreak walls on a capacity of tower evaporating unit in the windy condition is studied numerically. Geometry of the model corresponds to real Woo-Jin Power station, China. Analogy of heat and mass transfer was used that allowed to consider aerodynamic of one-dimension flow and carried out detailed 3D calculations applying modern PC. Heat transfer coefficient of irrigator and its hydrodynamic resistance were established according to experimental data on total air rate in cooling tower. Numerical model is tested and verified with experimental data.Nonlinear dependence of CT thermal performance on wind velocity is demonstrated with the minimum (critical wind velocity at ucr ~ 8 m/s for simulated system. Application of windbreak walls does not change the value of the critical wind velocity, but may improves performance of cooling unit at moderate and strong wind conditions. Simultaneous usage of windbreak walls and overshower deflectors may increase efficiency up to 20–30 % for the deflectors angle a = 60o. Simulation let one analyze aerodynamic patterns, induced inside cooling tower and homogeneity of velocities’ field in irrigator’s area.Presented results may be helpful for the CT aerodynamic design optimization, particularly, for perspective hybrid type CTs.

  1. Spin orbit torques and chiral spin textures in ultrathin magnetic films (Presentation Recording) (United States)

    Beach, Geoffrey S.


    Spin orbit coupling at interfaces can give rise to chiral magnetic textures such as homochiral domain walls and skyrmions, as well as current-induced torques that can effectively manipulate them [1-3]. This talk will describe interface-driven spin-orbit torques and Dzyaloshinskii-Moriya interactions (DMIs) in ultrathin metallic ferromagnets adjacent to nonmagnetic heavy metals. We show that the DMI depends strongly on the heavy metal, differing by a factor of ~20 between Pt and Ta [4], and describe the influence of strong DMI on domain wall dynamics and spin Hall effect switching [5]. We present high-resolution magnetic force microscopy imaging of static magnetic textures that directly reveal the role of DMI and allow its strength to be quantified. Finally, we will describe how SOTs can be enhanced through interface engineering [6] and tuned by a gate voltage [7] by directly controlling the interfacial oxygen coordination at a ferromagnet/oxide interface [8]. [1] A. Thiaville, et al., Europhys. Lett. 100, 57002 (2012). [2] S. Emori, et al., Nature Mater. 12, 611 (2013). [3] J. Sampaio, V. Cros, S. Rohart, A. Thiaville, and A. Fert, Nature Nano. 8, 839 (2013). [4] S. Emori, et al., Phys. Rev. B 90, 184427 (2014). [5] N. Perez, et al., Appl. Phys. Lett. 104, 092403 (2014). [6] S. Woo, et al., Appl. Phys. Lett. 105, 212404 (2014). [7] S. Emori, et al., Appl. Phys. Lett. 105, 222401 (2014). [8] U. Bauer, et al., Nature Mater. 14, 174 (2015).

  2. Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 8 (Giordano Associates Inc, Long Branch, New Jersey - Hewlett Packard Company, Cupertino, California), FY1991 (United States)


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  3. Strategies for changing negative public attitudes toward organ donation in the People's Republic of China

    Directory of Open Access Journals (Sweden)

    Shumin X


    Full Text Available Xie Shumin,1 Stephanie Mu-Lian Woo,2 Zhang Lei3 1Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital of Central South University, Changsha, People's Republic of China; 2Harvard University, Cambridge, Massachusetts, USA; 3Department of Thoracic Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China Abstract: In recent decades, the demand for organ transplantation has risen rapidly worldwide, due to an increased incidence of vital organ failure. However, the scarcity of organs appropriate for transplantation has led to an organ shortage crisis. This article retrospectively reviews strategies to change negative public attitudes toward organ donation in the People's Republic of China. We strongly believe that efforts to publicize knowledge of organ donation, promote family discussions, train medical staff and students, establish incentive systems, and implement regulatory oversight may combat unfavorable Chinese public opinion toward organ donation and transplantation, thus potentially increasing the organ donation rate in the People's Republic of China. Keywords: influencing factors, attitudes, organ transplantation, organ failure


    Directory of Open Access Journals (Sweden)

    Ravindra Pal Singh


    Full Text Available Macroalgae are a diverse group of photosynthetic eukaryotic lower organisms and offer indispensable ecosystem services towards sustainable productivity of rocky coastal areas. The earlier studies have mainly focused on elucidation of the roles of the epiphytic bacterial communities in the ecophysiology of the host macroalga. However, mutualistic interactions have become topic of current interest. It is evident from recent studies that a fraction of epiphytic bacterial communities can be categorized as core microbial species, suggesting an obligate association. Epiphytic bacterial communities have also been reported to protect macroalgal surfaces from biofouling microorganisms through production of biologically active metabolites. Because of their intrinsic roles in the host life cycle, the host in turn may provide necessary organic nutrients in order to woo pelagic microbial communities to settle on the host surfaces. However, the precise composition of microbiomes and their functional partnership with hosts are hardly understood. In contrast, the microbial studies associated with human skin and gut and plants have significantly advanced our knowledge on microbiome and their functional interactions with the host. This has led to manipulation of the microbial flora of the human gut and of agricultural plants for improving health and performance. Therefore, it is highly imperative to investigate the functional microbiome that is closely involved in the life cycles of the host macroalgae using high-throughput techniques (metagenomics and metatranscriptomics. The findings from such investigations would help in promoting health and productivity in macroalgal species through regulation of functionally active microbiome.

  5. Candidate genes for COPD: current evidence and research

    Directory of Open Access Journals (Sweden)

    Kim WJ


    Full Text Available Woo Jin Kim,1 Sang Do Lee2 1Department of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon, 2Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea Abstract: COPD is a common complex disease characterized by progressive airflow limitation. Several genome-wide association studies (GWASs have discovered genes that are associated with COPD. Recently, candidate genes for COPD identified by GWASs include CHRNA3/5 (cholinergic nicotine receptor alpha 3/5, IREB2 (iron regulatory binding protein 2, HHIP (hedgehog-interacting protein, FAM13A (family with sequence similarity 13, member A, and AGER (advanced glycosylation end product–specific receptor. Their association with COPD susceptibility has been replicated in multiple populations. Since these candidate genes have not been considered in COPD, their pathological roles are still largely unknown. Herein, we review some evidences that they can be effective drug targets or serve as biomarkers for diagnosis or subtyping. However, more study is required to understand the functional roles of these candidate genes. Future research is needed to characterize the effect of genetic variants, validate gene function in humans and model systems, and elucidate the genes’ transcriptional and posttranscriptional regulatory mechanisms. Keywords: chronic obstructive pulmonary disease, genetics, genome-wide association study

  6. Department of Defense Contractor Establishment Code (CEC). Alphabet Listing. Volume 1 (United States)


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  7. Prospects of pharmaceuticals and biopharmaceuticals loaded microparticles prepared by double emulsion technique for controlled delivery. (United States)

    Giri, Tapan Kumar; Choudhary, Chhatrapal; Ajazuddin; Alexander, Amit; Badwaik, Hemant; Tripathi, Dulal Krishna


    Several methods and techniques are potentially useful for the preparation of microparticles in the field of controlled drug delivery. The type and the size of the microparticles, the entrapment, release characteristics and stability of drug in microparticles in the formulations are dependent on the method used. One of the most common methods of preparing microparticles is the single emulsion technique. Poorly soluble, lipophilic drugs are successfully retained within the microparticles prepared by this method. However, the encapsulation of highly water soluble compounds including protein and peptides presents formidable challenges to the researchers. The successful encapsulation of such compounds requires high drug loading in the microparticles, prevention of protein and peptide degradation by the encapsulation method involved and predictable release, both rate and extent, of the drug compound from the microparticles. The above mentioned problems can be overcome by using the double emulsion technique, alternatively called as multiple emulsion technique. Aiming to achieve this various techniques have been examined to prepare stable formulations utilizing w/o/w, s/o/w, w/o/o, and s/o/o type double emulsion methods. This article reviews the current state of the art in double emulsion based technologies for the preparation of microparticles including the investigation of various classes of substances that are pharmaceutically and biopharmaceutically active.

  8. Prospects of pharmaceuticals and biopharmaceuticals loaded microparticles prepared by double emulsion technique for controlled delivery (United States)

    Giri, Tapan Kumar; Choudhary, Chhatrapal; Ajazuddin; Alexander, Amit; Badwaik, Hemant; Tripathi, Dulal Krishna


    Several methods and techniques are potentially useful for the preparation of microparticles in the field of controlled drug delivery. The type and the size of the microparticles, the entrapment, release characteristics and stability of drug in microparticles in the formulations are dependent on the method used. One of the most common methods of preparing microparticles is the single emulsion technique. Poorly soluble, lipophilic drugs are successfully retained within the microparticles prepared by this method. However, the encapsulation of highly water soluble compounds including protein and peptides presents formidable challenges to the researchers. The successful encapsulation of such compounds requires high drug loading in the microparticles, prevention of protein and peptide degradation by the encapsulation method involved and predictable release, both rate and extent, of the drug compound from the microparticles. The above mentioned problems can be overcome by using the double emulsion technique, alternatively called as multiple emulsion technique. Aiming to achieve this various techniques have been examined to prepare stable formulations utilizing w/o/w, s/o/w, w/o/o, and s/o/o type double emulsion methods. This article reviews the current state of the art in double emulsion based technologies for the preparation of microparticles including the investigation of various classes of substances that are pharmaceutically and biopharmaceutically active. PMID:23960828

  9. DoD Statistical Report on the Military Retirement System. Fiscal Year 1983. (United States)


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  10. Hearing Mouth Shapes: Sound Symbolism and the Reverse McGurk Effect

    Directory of Open Access Journals (Sweden)

    Charles Spence


    Full Text Available In their recent article, Sweeny, Guzman-Martinez, Ortega, Grabowecky, and Suzuki (2012 demonstrate that heard speech sounds modulate the perceived shape of briefly presented visual stimuli. Ovals, whose aspect ratio (relating width to height varied on a trial-by-trial basis, were rated as looking wider when a /woo/ sound was presented, and as taller when a /wee/ sound was presented instead. On the one hand, these findings add to a growing body of evidence demonstrating that audiovisual correspondences can have perceptual (as well as decisional effects. On the other hand, they prompt a question concerning their origin. Although the currently popular view is that crossmodal correspondences are based on the internalization of the natural multisensory statistics of the environment (see Spence, 2011, these new results suggest instead that certain correspondences may actually be based on the sensorimotor responses associated with human vocalizations. As such, the findings of Sweeny et al. help to breathe new life into Sapir's (1929 once-popular “embodied” explanation of sound symbolism. Furthermore, they pose a challenge for those psychologists wanting to determine which among a number of plausible accounts best explains the available data on crossmodal correspondences.

  11. Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 10 (International Bus MCHS Corp, New Orleans, Louisiana - Lemmen Pontiac and Farm Equipment Co Inc, Coopersville, Michigan), FY1991 (United States)


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  12. Reverberation Mapping of PG 0934+013 with the Southern African Large Telescope (United States)

    Park, Songyoun; Woo, Jong-Hak; Romero-Colmenero, Encarni; Crawford, Steven M.; Park, Dawoo; Cho, Hojin; Jeon, Yiseul; Choi, Changsu; Barth, Aaron J.; Pei, Liuyi; Hickox, Ryan C.; Sung, Hyun-Il; Im, Myungshin


    We present the variability and time-lag measurements of PG 0934+013 based on a photometric and spectroscopic monitoring campaign over a two year period. We obtained 46 epochs of data from the spectroscopic campaign, which was carried out using the Southern African Large Telescope with ˜1 week cadence over two sets of four month-long observing period, while we obtained 80 epochs of B-band imaging data using a few 1 m class telescopes. Due to the seven month gap between the two observing periods, we separately measured the time lags of broad emission lines, including Hβ, by comparing the emission line light curve with the B-band continuum light curve using the cross-correlation function techniques. We determined the Hβ lag, {τ }{cent}={8.46}-2.14+2.08 days in the observed frame based on Year 2 data, while the time lag from Year 1 data was not reliably determined. Using the rms spectrum of Year 2 data, we measured the Hβ line dispersion {σ }{line} = 668 ± 44 km s-1 after correcting for the spectral resolution. Adopting a virial factor f = 4.47 from Woo et al. (2015), we determined the black hole mass M BH = {3.13}-0.93+0.91× {10}6 M ⊙, based on the Hβ time lag and velocity.

  13. From crops to products for crops: preserving the ecosystem through the use of bio-based molecules

    Directory of Open Access Journals (Sweden)

    Godard Anaïs


    Full Text Available In a context of dwindling oil reserves and environmental pressures, the chemical industry needs to innovate by developing new processes for producing bioproducts from raw plant materials. Unsaturated fatty acids from vegetable oils constitute a highly promising renewable resource that can be used to diversify productions, decreasing reliance on petroleum. A starting material rich in oleic acid has been obtained through the selection of high-oleic sunflower varieties and enzymatic hydrolysis of the oil they produce. The double bonds of this unsaturated raw material have been cleaved in green oxidizing conditions involving a biphasic lipophilic-aqueous system including hydrogen peroxide as an oxidant and a peroxo-tungsten complex Q3 {PO2[WO(O22]4} as a phase-transfer catalyst (PTC and co-oxidant. This PTC efficiently transferred oxygen to the substrate in the lipophilic phase. A mono-acid (pelargonic acid and a di-acid (azelaic acid, with shorter, unusual hydrocarbon chains not present in the natural state, were synthesized and purified through an intensive process. Pelargonic acid was then formulated as an environmentally friendly biocontrol agent for weeds. We extended this green process of oxidative scission to other fatty acids and derivatives, to obtain other short-chain acids with diverse potential applications. This production chain (crops, reaction and purification processes, products, applications is based on a sustainable development strategy.

  14. Decontamination and decommissioning of the Mayaguez (Puerto Rico) facility

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, P.K.; Freemerman, R.L. [Bechtel National, Inc., Oak Ridge, TN (United States)


    On February 6, 1987 the US Department of Energy (DOE) awarded the final phase of the decontamination and decommissioning of the nuclear and reactor facilities at the Center for Energy and Environmental Research (CEER), in Mayaguez, Puerto Rico. Bechtel National, Inc., was made the decontamination and decommissioning (D and D) contractor. The goal of the project was to enable DOE to proceed with release of the CEER facility for use by the University of Puerto Rico, who was the operator. This presentation describes that project and lesson learned during its progress. The CEER facility was established in 1957 as the Puerto Rico Nuclear Center, a part of the Atoms for Peace Program. It was a nuclear training and research institution with emphasis on the needs of Latin America. It originally consisted of a 1-megawatt Materials Testing Reactor (MTR), support facilities and research laboratories. After eleven years of operation the MTR was shutdown and defueled. A 2-megawatt TRIGA reactor was installed in 1972 and operated until 1976, when it woo was shutdown. Other radioactive facilities at the center included a 10-watt homogeneous L-77 training reactor, a natural uranium graphite-moderated subcritical assembly, a 200KV particle accelerator, and a 15,000 Ci Co-60 irradiation facility. Support facilities included radiochemistry laboratories, counting rooms and two hot cells. As the emphasis shifted to non-nuclear energy technology a name change resulted in the CEER designation, and plans were started for the decontamination and decommissioning effort.

  15. Overground Excess Sound Attenuation (ESA). Volume 1. Experimental Study for Flat Grassy Terrains. (United States)


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  16. Epidemiology of brucellosis among cattle in Korea from 2001 to 2011 (United States)

    Moon, Oun-Kyong; Lee, Soo-Han; Lee, Won-Chang; Her, Moon; Jeong, Wooseog; Jung, Suk-Chan; Kim, Do-Soon


    In the present study, the outbreak patterns of bovine brucellosis in Korea from 2000 to 2011 were analyzed to understand the epidemiological evolution of this disease in the country. A total of 85,521 brucella reactor animals were identified during 14,215 outbreaks over the 12-year study period. The number of bovine brucellosis cases increased after 2003 and peaked in 2006 before decreasing thereafter. The majority of the bovine brucellosis cases were Korean native cattle, Han Woo. The numbers of human brucellosis cases and cattle outbreaks increased and decreased in the same pattern. The correlation coefficient for human and bovine cases per year was 0.96 (95% confidence interval = 0.86~0.99; p brucellosis appeared to be affected by the intensity of eradication programs that mainly involved a test-and-slaughter policy. Findings from the present study were based on freely available statistics from web pages maintained by government agencies. This unlimited access to information demonstrates the usefulness of government statistics for continually monitoring the health of animal populations. PMID:25234321

  17. Boomers versus Millennials: Online Media Influence on Media Performance and Candidate Evaluations

    Directory of Open Access Journals (Sweden)

    Terri Towner


    Full Text Available Facebook posts, YouTube videos, tweets and wooing political bloggers have become standard practice in marketing political campaigns. Research has demonstrated the effect of new media on a host of politically-related behavior, including political participation, knowledge acquisition, group formation and self-efficacy. Yet, issues related to media trust, media performance and candidate evaluations have not been fully explored. In addition, much of the political marketing research looks exclusively at the Millennial age cohort, ignoring other age groups, particularly Baby Boomers. This case study addresses whether attention to traditional (i.e., television, hard-copy newspapers and radio and online media sources (i.e., political candidate websites, television network websites, online newspapers, Facebook, Twitter, YouTube, Tumblr and political blogs about the 2012 U.S. presidential campaign influences Millennials and Baby Boomers’ media trust and performance ratings, as well as candidate evaluations. Panel surveys were completed by both age cohorts, Millennials (n = 431 and Baby Boomers (n = 360, during the last two weeks of the presidential election. Findings indicate that traditional sources, specifically television, rather than online sources are significantly linked to media trust and performance ratings among both Boomers and Millennials. Attention to traditional media for campaign information predicts Boomers’ candidate evaluations, whereas Millennials’ candidate evaluations are influenced by online sources, such as Facebook and candidate websites.

  18. Predictors of premature discontinuation of outpatient treatment after discharge of patients with posttraumatic stress disorder

    Directory of Open Access Journals (Sweden)

    Wang HR


    Full Text Available Hee Ryung Wang, Young Sup Woo, Tae-Youn Jun, Won-Myong Bahk Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea Objective: This study aimed to examine the sociodemographic and disease-related variables associated with the premature discontinuation of psychiatric outpatient treatment after discharge among patients with noncombat-related posttraumatic stress disorder. Methods: We retrospectively reviewed the medical records of patients who were discharged with a diagnosis of posttraumatic stress disorder. Results: Fifty-five percent of subjects (57/104 prematurely discontinued outpatient treatment within 6 months of discharge. Comparing sociodemographic variables between the 6-month non-follow-up group and 6-month follow-up group, there were no variables that differed between the two groups. However, comparing disease-related variables, the 6-month follow-up group showed a longer hospitalization duration and higher Global Assessment of Function score at discharge. The logistic regression analysis showed that a shorter duration of hospitalization predicted premature discontinuation of outpatient treatment within 6 months of discharge. Conclusion: The duration of psychiatric hospitalization for posttraumatic stress disorder appeared to influence the premature discontinuation of outpatient treatment after discharge. Keywords: posttraumatic stress disorder, discontinuation, compliance, predictor

  19. The beneficial effects of honeybee-venom serum on facial wrinkles in humans

    Directory of Open Access Journals (Sweden)

    Han SM


    Full Text Available Sang Mi Han,1 In Phyo Hong,1 Soon Ok Woo,1 Sung Nam Chun,2 Kwan Kyu Park,3 Young Mee Nicholls,4 Sok Cheon Pak5 1Department of Agricultural Biology, National Academy of Agricultural Science, Wanju, 2Dong Sung Pharmaceuticals Co Ltd, Seoul, 3Department of Pathology, School of Medicine, Catholic University of Daegu, Daegu, South Korea; 4Manuka Doctor Ltd, Auckland, New Zealand; 5School of Biomedical Sciences, Charles Sturt University, Bathurst, NSW, Australia Abstract: Facial wrinkles are an undesirable outcome caused by extrinsic photodamage and intrinsic aging processes. Currently, no effective strategies are known to prevent facial wrinkles. We assessed the beneficial effects of bee-venom serum on the clinical signs of aging skin. Our results show that bee-venom serum treatment clinically improved facial wrinkles by decreasing total wrinkle area, total wrinkle count, and average wrinkle depth. Therefore, bee-venom serum may be effective for the improvement of skin wrinkles. Keywords: bee venom, wrinkle, area, count, depth

  20. Validation of the Rotorcraft Flight Simulation Program (C81) for Articulated Rotor Helicopters through Correlation with Flight Data (United States)


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  1. 'Blue Whale Challenge': A Game or Crime? (United States)

    Mukhra, Richa; Baryah, Neha; Krishan, Kewal; Kanchan, Tanuj


    A bewildering range of games are emerging every other day with newer elements of fun and entertainment to woo youngsters. Games are meant to reduce stress and enhance the cognitive development of children as well as adults. Teenagers are always curious to indulge in newer games; and e-gaming is one such platform providing an easy access and quicker means of entertainment. The particular game challenge which has taken the world by storm is the dangerous "Blue Whale Challenge" often involving vulnerable teenagers. The Blue Whale Challenge is neither an application nor internet based game but the users get a link through social media chat groups to enter this "deadly" challenge game. This probably is the only game where the participant has to end his/her life to complete the game. The innocent teenagers are being targeted based on their depressed psychology and are coercively isolated from their social milieux on the pretext of keeping the challenges confidential. To add to the woes, no option is offered to quit the challenge even if the contender is unable to complete the challenge. Blue Whale Challenge in its sheer form could be seen as an illegal, unethical and inhumane endeavor in our present society. The present communication discusses the severe effects of the game on teenagers, the ethical concerns involved and the preventive measures necessary to curb it.

  2. Late Quaternary activity along the Ferrara thrust inferred from stratigraphic architecture and geophysical surveys (United States)

    Stefani, Marco; Bignardi, Samuel; Caputo, Riccardo; Minarelli, Luca; Abu-Zeid, Nasser; Santarato, Giovanni


    Since Late Miocene, the Emilia-Romagna portion of the Po Plain-Adriatic foredeep basin was progressively affected by compressional deformation, due to the northward propagation of the Apennines fold-and-thrust belt. The major tectonic structures within the basin have been recognised and are relatively well known, thanks to the widespread, even if outdated, seismic survey, performed after WW II, for hydrocarbon exploration. More recently, a large amount of surface and shallow-subsurface information has been provided by the CARG geological mapping project. The region therefore provides a valuable opportunity to discuss the genetic relationship between tectonic deformation, eustatic-paleoclimatic fluctuations, and depositional architecture. The activity of blind thrusts and fault-propagation folds induced repeated angular unconformities and impressive lateral variations in the Pliocene-Quaternary stratigraphy, causing thickness changes, from a few metres, close to the Apennines piedmont line, to more than 9 km, in fast subsiding depocenters (e.g. Lido di Savio). In the Ferrara region, the post-Miocene succession ranges from about 4 km, west of Sant'Agostino, to less than 200 m, on the Casaglia anticline, where Late Quaternary fluvial strata rest on Miocene marine marls, with an angular unconformity relationship. In this sector of the Po Plain, the tip-line of the northernmost thrust has been reconstructed north of the Po River (Occhiobello) and is associated with the growth of a large fold (Ferrara-Casaglia anticline), cross-cut by a complex splay of minor backthrusts and reverse faults. The thrust-anticline structure hosts an energy producing geothermal field, whose hydrogeological behaviour is largely influenced by the fracture pattern. The Apennines frontal thrust probably provided the seismic source for the earthquakes that severely damaged Ferrara, during the 1570 a.D. fall season, as documented by the structural damage still visible in many historic buildings (e

  3. Cinema, paesaggio e turismo “andaluzadas”: la Spagna andalusizzata, patrimonio retroproiettato / Cinema, landscape and “andaluzadas” tourism: the Andalusian Spain, a rear-projected heritage

    Directory of Open Access Journals (Sweden)

    Rocío Liáñez Andrades


    Full Text Available La Spagna si è proiettata cinematograficamente al turismo internazionale attraverso la sua immagine più pittoresca e singolare: l’Andalusia. In questo modo, anche nelle produzioni realizzate in altre regioni spagnole (Galizia, Madrid, Castiglia-La Mancia, Catalogna compare lo stereotipo più vincolato alla sua immagine romantica secolare.Questa sineddoche identitaria dell'essere spagnolo è stata agevolata dalle istituzioni turistiche, coscienti della loro capacità di attrazione sul turista straniero, e anche dagli stessi spagnoli, che hanno presentato una visione satirica di questo fenomeno di furto di identità nazionale.Per documentare la nostra ipotesi è stata eseguita l’analisi cinematografica (semiotica e di contenuto di una lista di film proposti, produzioni spagnole e coproduzioni con partecipazione o supporto nazionale. Si tratta di produzioni che non esitano a immergersi negli stereotipi più radicati dell’immaginario andaluso, riconoscendoli e riconoscendosi in questi. Ne emerge in questo modo sia la vocazione etnografica e folkloristica delle produzioni destinate alla proiezione internazionale, sia l’impoverimento della suddetta immagine per l’utente nazionale.Quest’articolo percorre le produzioni sopra citate ed espone l’eventuale collegamento di questi “film pasticcio” con film di recente uscita, come Mission: Impossible 2 (John Woo, 2000, Knight and day (James Mangold, 2010 o Zindagi na milegi dobara (Zoya Akhtar, 2012. Spain presented itself in films in order to promote international tourism through its picturesque and unique image: Andalusia. In this way, including in productions that took place in other regions (Galicia, Madrid, Castile-La Mancha, Catalonia, the basic and most cliché Andalusian appears in its romantic and secular image. This identifying synecdoche of “Spanish Identity” was seen as favored by touristic institutions. Aware of their power of attraction over foreign touristic consumers

  4. Association of blood eosinophils and plasma periostin with FEV1 response after 3-month inhaled corticosteroid and long-acting beta2-agonist treatment in stable COPD patients

    Directory of Open Access Journals (Sweden)

    Park HY


    Full Text Available Hye Yun Park,1 Hyun Lee,1 Won-Jung Koh,1 Seonwoo Kim,2 Ina Jeong,3 Hyeon-Kyoung Koo,4 Tae-Hyung Kim,5 Jin Woo Kim,6 Woo Jin Kim,7 Yeon-Mok Oh,8 Don D Sin,9 Seong Yong Lim,10,* Sang-Do Lee8,* On behalf of the KOLD Study Group 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; 2Biostatistics Team, Samsung Biomedical Research Institute, Seoul, Korea; 3Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Medical Center, Seoul, Korea; 4Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea; 5Division of Pulmonary and Critical Care Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Gyeonggi-do, Korea; 6Division of Pulmonology, Department of Internal Medicine, Uijeongbu St Mary’s Hospital, Gyunggi-do, Korea; 7Department of Internal Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Korea; 8Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; 9Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, BC, Canada; 10Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea *These authors contributed equally to this work Background: COPD patients with increased airway eosinophilic inflammation show a favorable response to inhaled corticosteroids (ICS in combination with a long-acting bronchodilator. Recent studies have demonstrated a significant correlation of sputum eosinophilia with blood eosinophils and periostin. We investigated whether high blood eosinophils and plasma periostin were associated

  5. The response and recovery of the Arabidopsis thaliana transcriptome to phosphate starvation

    KAUST Repository

    Woo, Jongchan


    Background: Over application of phosphate fertilizers in modern agriculture contaminates waterways and disrupts natural ecosystems. Nevertheless, this is a common practice among farmers, especially in developing countries as abundant fertilizers are believed to boost crop yields. The study of plant phosphate metabolism and its underlying genetic pathways is key to discovering methods of efficient fertilizer usage. The work presented here describes a genome-wide resource on the molecular dynamics underpinning the response and recovery in roots and shoots of Arabidopsis thaliana to phosphate-starvation.Results: Genome-wide profiling by micro- and tiling-arrays (accessible from GEO: GSE34004) revealed minimal overlap between root and shoot transcriptomes suggesting two independent phosphate-starvation regulons. Novel gene expression patterns were detected for over 1000 candidates and were classified as either initial, persistent, or latent responders. Comparative analysis to AtGenExpress identified cohorts of genes co-regulated across multiple stimuli. The hormone ABA displayed a dominant role in regulating many phosphate-responsive candidates. Analysis of co-regulation enabled the determination of specific versus generic members of closely related gene families with respect to phosphate-starvation. Thus, among others, we showed that PHR1-regulated members of closely related phosphate-responsive families (PHT1;1, PHT1;7-9, SPX1-3, and PHO1;H1) display greater specificity to phosphate-starvation than their more generic counterparts. Conclusion: Our results uncover much larger, staged responses to phosphate-starvation than previously described. To our knowledge, this work describes the most complete genome-wide data on plant nutrient stress to-date. 2012 Woo et al.; licensee BioMed Central Ltd.

  6. Pollution and acne: is there a link?

    Directory of Open Access Journals (Sweden)

    Krutmann J


    Full Text Available Jean Krutmann,1 Dominique Moyal,2 Wei Liu,3 Sanjiv Kandahari,4 Geun-Soo Lee,5 Noppakun Nopadon,6 Leihong Flora Xiang,7 Sophie Seité2 1IUF – Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany; 2La Roche Posay Dermatological Laboratories, Asnières, France; 3Department of Dermatology, The General Hospital of Air Force, PLA, Beijing, People’s Republic of China; 4Dr. Kandhari’s Skin & Dental Clinic, New Delhi, India; 5Drs. Woo and Hann Skin Center, Yongsan-gu, Seoul, Korea; 6Division of Dermatology, Faculty of Medicine, Department of Medicine, Chulalongkorn University, Bangkok, Thailand; 7Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China Abstract: In recent years, the critical role that inflammation may play in the development and progression of acne has become increasingly recognized. The prevalence of acne is similar between Asian and Caucasian women, but Asian women have a higher prevalence of inflammatory acne. They also report their symptoms exacerbate during periods of high air pollution. The objective of this study was to review the current evidence that links air pollution to worsening of acne symptoms. Firstly, a group of five Asian and three European scientists with expertise in Dermatology reviewed the current literature and described current acne treatment practices in their countries. During this activity, they identified the need for further epidemiological and clinical research. Secondly, additional studies ensued which provided evidence that acne symptoms might exacerbate in regions of high ambient air pollution. Based on these findings, the authors suggest that people with acne should protect the natural barrier function of their skin with emollients and ultraviolet (UVA/UVB protection. Keywords: pollution, acne, Asia, epidemiology, pathophysiology

  7. Novel Antibacterial Nanofibrous PLLA Scaffolds (United States)

    Feng, Kai; Sun, Hongli; Bradley, Mark A.; Dupler, Ellen J.; Giannobile, William V.; Ma, Peter X.


    In order to achieve high local bioactivity and low systemic side effects of antibiotics in the treatment of dental, periodontal and bone infections, a localized and temporally controlled delivery system is crucial. In this study, a three-dimensional (3D) porous tissue engineering scaffold was developed with the ability to release antibiotics in a controlled fashion for long-term inhibition of bacterial growth. The highly soluble antibiotic drug, Doxycycline (DOXY), was successfully incorporated into PLGA nanospheres using a modified water-in-oil-in-oil (w/o/o) emulsion method. The PLGA nanospheres (NS) were then incorporated into prefabricated nanofibrous PLLA scaffolds with a well interconnected macroporous structure. The release kinetics of DOXY from four different PLGA NS formulations on a PLLA scaffold was investigated. DOXY could be released from the NS-scaffolds in a locally and temporally controlled manner. The DOXY release is controlled by DOXY diffusion out of the NS and is strongly dependent upon the physical and chemical properties of the PLGA. While PLGA50-6.5K, PLGA50-64K, and PLGA75-113K NS-scaffolds discharge DOXY rapidly with a high initial burst release, PLGA85-142K NS-scaffold can extend the release of DOXY to longer than 6 weeks with a low initial burst release. Compared to NS alone, the NS incorporated on a 3-D scaffold had significantly reduced the initial burst release. In vitro antibacterial tests of PLGA85 NS-scaffold demonstrated its ability to inhibit common bacterial growth (S.aureus and E.coli) for a prolonged duration. The successful incorporation of DOXY onto 3-D scaffolds and its controlled release from scaffolds extends the usage of nano-fibrous scaffolds from the delivery of large molecules such as growth factors to the delivery of small hydrophilic drugs, allowing for a broader application and a more complex tissue engineering strategy. PMID:20570700

  8. The Influence of Nietzsche’s Anthropology on the Works of George Bernard Shaw

    Directory of Open Access Journals (Sweden)

    Biljana Vlašković


    Full Text Available This paper identifies the traces of Friedrich Nietzsche’s anthropological philosophy in the dramatic, sociological, anthropological, and philosophical writings of George Bernard Shaw. Apart from the obvious use of Nietzsche’s term “the Superman” (Übermensch to serve the purposes of his own philosophy, the analysis shows further similarities between the two writers, namely that Shaw modified Nietzsche’s expression “the will to power”, as well as Schopenhauer’s concept of will as the world’s essence, and termed it the “Life Force”, which will enable a “creative evolution” of humans into a higher being, an Overman, or a Superman. Also concerning this is the role that Shaw gives to women in this process of creative evolution, by making the female the dominant gender, and in so doing radically deconstructing the deeply rooted 19th century view of woman as a being whose natural habitat is the family home, and whose role in wooing is exclusively passive. Such an attitude led many critics to believe that Shaw was a misogynist of the same kind as Schopenhauer and Nietzsche. However, Shawian discourse as a whole exhibits а vehement support of the feminist struggles for the gender equality, which made the author a favorite in feminist circles. Different perspectives in Shaw’s anthropology mirror Nietzsche’s demand for the “transvaluation of all values”, and this alone is necessary to provide a constant change, which, according to both authors, is the only thing that is certain and constant in this world.

  9. Relationship between plasma matrix metalloproteinase levels, pulmonary function, bronchodilator response, and emphysema severity

    Directory of Open Access Journals (Sweden)

    Koo HK


    Full Text Available Hyeon-Kyoung Koo,1 Yoonki Hong,2 Myoung Nam Lim,2 Jae-Joon Yim,3 Woo Jin Kim2 1Department of Internal Medicine, Division of Pulmonary and Critical Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, 2Department of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon-si, 3Department of Internal Medicine and Lung Institute, Division of Pulmonary and Critical Care Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea Objective: Chronic obstructive pulmonary disease (COPD is characterized by chronic inflammation in the airway and lung. A protease–antiprotease imbalance has been suggested as a possible pathogenic mechanism for COPD. We evaluated the relationship between matrix metalloproteinase (MMP levels and COPD severity.Methods: Plasma levels of MMP-1, MMP-8, MMP-9, and MMP-12 were measured in 57 COPD patients and 36 normal controls. The relationship between MMP levels and lung function, emphysema index, bronchial wall thickness, pulmonary artery pressure, and quality of life was examined using general linear regression analyses.Results: There were significant associations of MMP-1 with bronchodilator reversibility and of MMP-8 and MMP-9 with lung function. Also, MMP-1, MMP-8, and MMP-9 levels were correlated with the emphysema index, independent of lung function. However, MMP-12 was not associated with lung function or emphysema severity. Associations between MMP levels and bronchial wall thickness, pulmonary artery pressure, and quality of life were not statistically significant.Conclusion: Plasma levels of MMP-1, MMP-8, and MMP-9 are associated with COPD severity and can be used as a biomarker to better understand the characteristics of COPD patients. Keywords: matrix metalloproteinase, pulmonary disease, chronic obstructive, respiratory function test, pulmonary emphysema, bronchodilator response


    Directory of Open Access Journals (Sweden)

    S. Soemantri


    Full Text Available Surkesda NAD 2006 collected birth history data reported by ever married women of the householdsamples. Birth history data were used to estimate childhood mortality for Nanggroe Aceh Darussalam(NAD. Both direct and indirect estimation of childhood mortality were applied. Indirect estimationused Coale Demeny West model (Trussel equations and UN general model (Palloni-Heligmanequations. Both direct and indirect estimation of childhood mortality surprisingly gave similarestimates of Infant Mortality Rate (IMR. Child Mortality Rate (CMR or Under-five Mortality Rate(U5MR for the period about five years before survey. Estimates of IMR. CMR and U5MR wererespectively 48 per 1000, 15 per WOO and 62 per 1000. The estimate of IMR of 48 per 1000 is muchhigher than estimate for NAD based on BPS Population Projection, i.e. 39-40 per 1000 for 2000-2005. Life expectancy at birth for NAD derived from Coale Demeny West model for IMR 48 per 1000 ormortality level of about 20. was 65.5 years. This figure is lower than BPS projection of life expectancyat birth for NAD which was 67.2 years. Direct estimation approach indicated the rise of childhoodmortality recently, which may be due to the impact of earth quake/tsunami that hit NAD in 2004. Therise of childhood mortality could not be recognized by indirect estimation approach. The rise ofmortality recently may be true since disaster of earth quake/tsunami had hampered the availability ofhealth personnel (doctors and midwives and household environment (accessibility to safe water or safetoilet. There is an indication of the negative relationship between availability of doctors and midwives,or accessibility of safe water and safe toilet with childhood survivorship in NAD. Keyword: IMR, CMR, U5MR, life expectency

  11. Estimation of health state utilities in breast cancer

    Directory of Open Access Journals (Sweden)

    Kim SH


    Full Text Available Seon-Ha Kim,1 Min-Woo Jo,2 Minsu Ock,2 Hyeon-Jeong Lee,2 Jong-Won Lee3,4 1Department of Nursing, College of Nursing, Dankook University, Cheonan, 2Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, 3Department of Breast and Endocrine Surgery, Asan Medical Center, Seoul, 4Department of Surgery, University of Ulsan College of Medicine, Seoul, South Korea Purpose: The aim of this study is to determine the utility of breast cancer health states using the standard gamble (SG and visual analog scale (VAS methods in the Korean general population.Materials and methods: Eight hypothetical breast cancer health states were developed based on patient education material and previous publications. Data from 509 individuals from the Korean general population were used to evaluate breast cancer health states using the VAS and the SG methods, which were obtained via computer-assisted personal interviews. Mean utility values were calculated for each human papillomavirus (HPV-related health state.Results: The rank of health states was identical between two valuation methods. SG values were higher than VAS values in all health states. The utility values derived from SG were 0.801 (noninvasive breast cancer with mastectomy and followed by reconstruction, 0.790 (noninvasive breast cancer with mastectomy only, 0.779 (noninvasive breast cancer with breast-conserving surgery and radiation therapy, 0.731 (invasive breast cancer with surgery, radiation therapy, and/or chemotherapy, 0.610 (locally advanced breast cancer with radical mastectomy with radiation therapy, 0.587 (inoperable locally advanced breast cancer, 0.496 (loco-regional recurrent breast cancer, and 0.352 (metastatic breast cancer.Conclusion: Our findings might be useful for economic evaluation of breast cancer screening and interventions in general populations. Keywords: breast neoplasm, Korea, quality-adjusted life years, quality of life

  12. The 2002 HBR list. Breakthrough ideas for today's business agenda. (United States)


    In the last year, war broke out, the economy took a nosedive, and an alarming number of businesses went belly up. Thus it is with some urgency that we bring you this year's list of the seven best new business ideas to help you find your way through these complex times. History Returns. Many thought that the fall of the Berlin Wall marked the beginning of a new world order, one in which history didn't matter. But September 11, 2001, put an end to that theory. And it raised serious questions about globalization, security, and strategy. Enter the Everyday Leader--at Last. CEOs are used to getting all the glory, but leaders outside the limelight--middle managers and tempered radicals--are beginning to receive the attention they deserve. The Internet Is Not About You. The real value of the Internet may lie less in connecting individuals than in connecting databases, servers, and devices--a web not of people but of machines. Mind Your Behavior. Behavioral scientists are beginning to be able to accurately predict the ways individuals and crowds will respond to stimuli, and the implications for business are profound. Don't Delight Your Customers Away. Companies have wooed and coddled customers for too long. The truth is, people delight in being teased and are repelled by those who try too hard to befriend them. Games Are for Losers. Financial game playing and verbal politicking are seriously damaging businesses. Honesty is more than an admirable virtue; it's the foundation of every lasting enterprise. Three Cheers for Creativity (Sometimes). Creativity and best-practice replication are fundamentally different undertakings. Managers who mix the two achieve creativity that is merely incremental and replication that is sadly inept.

  13. Some Dust/Ocean Connections - Past, Present, and Future (United States)

    Duce, R. A.


    Atmospheric dust has been the subject of communications for more than 3000 years, since the ancient Chinese book Chronicles Reported on Bamboo Shoots in 1150 BC. Similar reports of hwangsa and woo-tou in ancient Korean and kosa in ancient Japanese literature also indicated major Asian dust events in those areas. Western observers noted dust storms in India and Afghanistan in the early 1800s, while in the 1840s Darwin surmised that Sahara dust could be an important component of marine sedimentation in the North Atlantic. More recent interest has focused on the importance of dust as a source of the nutrients iron and phosphorus in the global ocean and the role of iron as a limiting nutrient in many areas of the surface ocean. While significant progress has been made in the past 25 years in identifying important dust/ocean connections, many issues remain. Included are the relative dearth of long-term measurements of atmospheric dust (and iron and phosphorus) over and deposition to the ocean, especially in the southern hemisphere; comparisons between modeled and measured deposition of dust to the ocean; and the solubility of iron and phosphorus (and thus their availability as nutrients) after the mineral matter enters the ocean. Addressing these problems will certainly help to provide more accurate estimates of the input of dust to the ocean and its impacts. However, future changes in dust emissions in a warmer world as well as changes in the acid/base environment that mineral dust experiences during its transport and deposition as a result of emission controls on atmospheric NOx and SO2 are two facors that may change the input of these nutrients to the ocean and their impacts in the coming years. These and other issues will be reviewed in this paper.

  14. Neuropsychiatric symptoms in untreated Parkinson’s disease

    Directory of Open Access Journals (Sweden)

    Szatmari S


    Full Text Available Szabolcs Szatmari,1–3 Ben Min-Woo Illigens,4 Timo Siepmann,5,6 Alexandra Pinter,5,7 Annamaria Takats,8 Daniel Bereczki8 1Department of Neurology, Sibiu County Emergency Hospital, Sibiu, 22nd Department of Neurology, Targu Mures Emergency Clinical County Hospital, Targu Mures, Romania; 3János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary; 4Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; 5Center for Clinical Research and Management Education, Division of Health Care Sciences, Dresden International University, 6Department of Neurology, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany; 7Department of Family Medicine, 8Department of Neurology, Semmelweis University, Budapest, Hungary Abstract: Neuropsychiatric and cognitive symptoms are common in Parkinson’s disease (PD and may precede and exceed motor symptoms as major factors impacting disease course and quality of life. Neuropsychiatric symptoms (NPS in PD are various and are attributed to pathologic changes within multiple brain regions, to psychological stress, and to adverse effects of dopamine replacement therapy. Sleep disorders and mood symptoms such as apathy, depression, and anxiety may antedate the development of motor symptoms by years, while other NPS such as impulse control disorders, psychosis, and cognitive impairment are more common in later stages of the disease. Few studies report on NPS in the early, untreated phase of PD. We reviewed the current literature on NPS in PD with a focus on the early, drug-naive stages of PD. Among these early disease stages, premotor and early motor phases were separately addressed in our review, highlighting the underlying pathophysiological mechanisms as well as epidemiological characteristics, clinical features, risk factors, and available techniques of clinical assessment. Keywords: neuropsychiatric

  15. The One-Dimensional Cryogenic Implosion Campaign on OMEGA: Modeling, Experiments, and a Statistical Approach to Predict and Understand Direct-Drive Implosions (United States)

    Betti, R.


    The 1-D campaign on OMEGA is aimed at validating a novel approach to design cryogenic implosion experiments and provide valuable data to improve the accuracy of 1-D physics models. This new design methodology is being tested first on low-convergence, high-adiabat (α 6 to 7) implosions and will subsequently be applied to implosions with increasing convergence up to the level required for a hydro-equivalent demonstration of ignition. This design procedure assumes that the hydrodynamic codes used in implosion designs lack the necessary physics and that measurements of implosion properties are imperfect. It also assumes that while the measurements may have significant systematic errors, the shot-to-shot variations are small and that cryogenic implosion data are reproducible as observed on OMEGA. One of the goals of the 1-D campaign is to find a mapping of the data to the code results and use the mapping relations to design future implosions. In the 1-D campaign, this predictive methodology was used to design eight implosions using a simple two-shock pulse design, leading to pre-shot predictions of yields within 5% and ion temperatures within 4% of the experimental values. These implosions have also produced the highest neutron yield of 1014 in OMEGA cryogenic implosion experiments with an areal density of 100 mg/cm2. Furthermore, the results from this campaign have been used to test the validity of the 1-D physics models used in the radiation-hydrodynamics codes. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DENA0001944 and LLNL under Contract DE-AC52-07NA27344. * In collaboration with J.P. Knauer, V. Gopalaswamy, D. Patel, K.M. Woo, K.S. Anderson, A. Bose, A.R. Christopherson, V.Yu. Glebov, F.J. Marshall, S.P. Regan, P.B. Radha, C. Stoeckl, and E.M. Campbell.

  16. [A life of Ryu Sang-Kyu, a colonial modernized intellectual]. (United States)

    Choi, Q Jin; Hwang, Sang Ik; Kim, Soo Youn


    Many of the Korean intellectuals resisted against suppression of Japanese Imperialism with the people during the Japanese occupation period. Ryu Sang-Kyu was also one of those intellectuals. Ryu Sang-Kyu was born in Gang-gye of North Pyongan-do on 10th November, 1897. He entered Keijo Medical College as one of the first entering students in 1916. However, at the end of his third year, he participated in the 3.1 Independence Movement of Korea and was suspended from the college which was run by the Japanese on account of his participation. Then moving to Shanghai, he joined Heung Sa Dan, an active patriotic group fighting for independence of Korea. He initiated the provisional government of Korea as a network investigator and he played second string to Ahn Chang-Ho, one of major Korean independence activists for four years. In 1923, following Ahn Chang-Ho's advice, he returned to Keijo Medical College to complete the course. Even in colonial Korea, he continued independence movement and was involved in Dong Woo Hoe, the branch of Heung Sa Dan in Korea. After the graduation of Keijo Medical College in 1927, he had served at the department of surgery in Keijo Medical College. In 1930, he participated in founding of the Korean Medical Association. He also raised public awareness by writing to many articles on hygiene and public health issues in public journals and newspapers. In short, he did his best as an intellectual, a medical doctor, an activist of independence movement until he died from streptococcal infection on 7th July, 1936.

  17. Validation of a quantitative 12-multigene expression assay (Oncotype DX® Colon Cancer Assay in Korean patients with stage II colon cancer: implication of ethnic differences contributing to differences in gene expression

    Directory of Open Access Journals (Sweden)

    Jeong DH


    Full Text Available Duck Hyoun Jeong,1 Woo Ram Kim,1 Byung Soh Min,1 Young Wan Kim,2 Mi Kyung Song,3 Nam Kyu Kim1 1Department of Surgery, Yonsei University College of Medicine, Seoul, 2Department of Surgery, Wonju College of Medicine, Wonju, 3Department of Research Affairs, Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea Purpose: To evaluate the Recurrence Score® of the quantitative 12-multigene expression assay and to determine risk groups based on the continuous Recurrence Score® in Korean patients.Method: A total of 95 patients with pathological T3N0 tumors and mismatch repair-proficient tumors were enrolled. The Recurrence Score® was used to classify risk groups (low risk, <30; intermediate risk, 30–40; high risk, ≥41.Results: Fifty-four patients (56.8% were aged over 70 years. There were 49 men (51.6% and 56 cases of right-sided colon cancer (58.9%. Eight cases (8.4% had well-differentiated tumors, and 86 cases (90.5% showed moderate differentiation. Only one case (1.1% had a poorly differentiated tumor. Three patients (3.2% had lymphovascular invasion. Sixty-one patients were identified as low risk (64.2% and 34 patients as intermediate risk (35.8%. There were no high-risk patients. Although not significant, the 3-year recurrence risk increased with the Recurrence Score®.Conclusion: Distribution patterns of risk groups based on the Recurrence Score®, particularly the absence of a high-risk group, were different from the prior validation studies. These findings suggest that ethnic differences between Koreans and Western patients are potential contributing factors for different gene expressions in the quantitative 12-multigene expression assay. Keywords: colonic neoplasms, gene expression, adjuvant chemotherapy, ethnic groups

  18. Speak up! Speak out! Building HIV and AIDS awareness among Jamaican school children. (United States)

    Brissett, D; Griffiths-Irving, J


    The Government of Jamaica, through the Ministry of Health and other ministries, assisted by international funding agencies and members of non-governmental organizations, has diligently led the charge to reduce the incidence ofHIV and AIDS in Jamaica. Yet, the continued escalation in the infection rate attested to the need for education towards the reduction of stigma and discrimination, factors that fuel the spread of the virus. Significant efforts were made to woo corporations in Jamaica to redouble their efforts and provide resources to address the continued escalation of the AIDS epidemic in Jamaica. Scotiabank Jamaica responded with a unique educational initiative. The Scotiabank National Primary Schools HIV and AIDS Debating Competition in 2006-2007 was conducted over a seven-month period. It was opened to primary-level, government and private institutions islandwide. A total of91 institutions competed with each other debating 16 moots (i.e., topics) in 417 debates from the first preliminary rounds through to the final. Moots reflected curricular and extracurricular concerns, emphasized the values of compassion, healthy lifestyles, critical thinking and child rights; they also sent messages of anti-discrimination, and parental and community responsibilities. Whereas communication between the organizers and the schools was sometimes challenging, schools subscribed to the activity (debates) for the awareness it brought and for the potential for developing students. Attempts were also made to raise awareness among teachers, parents and the general community. Feedback at the end acclaimed the debates as a valuable strategy for building awareness as well as development of student potential and unity around a common cause.

  19. What is a free customer worth? Armchair calculations of nonpaying customers' value can lead to flawed strategies. (United States)

    Gupta, Sunil; Mela, Carl F


    Free customers who are subsidized by paying customers are essential to a vast array of businesses, such as media companies, employment services, and even IT providers. But because they generate revenue only indirectly, figuring out the true value of those customers--and how much attention to devote them--has always been a challenge. Traditional customer-valuation models don't help; they focus exclusively on paying customers and largely ignore network effects, or how customers help draw other customers to a business. Now a new model, devised by professors Gupta, of Harvard Business School, and Mela, of Fuqua School of Business, takes into account not only direct network effects (where buyers attract more buyers or sellers more sellers) but also indirect network effects (where buyers attract more sellers or vice versa) . The model calculates the precise long-term impact of each additional free customer on a company's profits, factoring in the degree to which he or she brings in other customers--whether free or paying--and the ripple effect of those customers. The model helped an online auction house make several critical decisions. The business made its money on fees charged to sellers but recognized that its free customers--its buyers--were valuable, too. As competition heated up, the company worried that it wasn't wooing enough buyers. Using the model, the business discovered that the network effects of buyers were indeed large and that those customers were worth over $1,000 each--much more than had been assumed. Armed with that information, the firm increased its research on buyers, invested more in targeting them with ads, and improved their experience. The model also helped the company identify the effects of various pricing strategies on sellers, showing that they became less price-sensitive over time. As a result, the company raised the fees it charged them as well.

  20. Variable Mixed Orbital Character in the Photoelectron Angular Distribution of NO_{2} (United States)

    Laws, Benjamin A.; Cavanagh, Steven J.; Lewis, Brenton R.; Gibson, Stephen T.


    NO_{2} a key component of photochemical smog and an important species in the Earth's atmosphere, is an example of a molecule which exhibits significant mixed orbital character in the HOMO. In photoelectron experiments the geometric properties of the parent anion orbital are reflected in the photoelectron angular distribution (PAD), an area of research that has benefited largely from the ability of velocity-map imaging (VMI) to simultaneously record both the energetic and angular information, with 100% collection efficiency. Photoelectron spectra of NO_{2}^{-}, taken over a range of wavelengths (355nm-520nm) with the ANU's VMI spectrometer, reveal an anomalous jump in the anisotropy parameter near threshold. Consequently, the orbital behavior of NO_{2}^{-} appears to be quite different near threshold compared to detachment at higher photon energies. This surprising effect is due to the Wigner Threshold law, which causes p orbital character to dominate the photodetachment cross-section near threshold, before the mixed s/d orbital character becomes significant at higher electron kinetic energies. By extending recent work on binary character models to form a more general expression, the variable mixed orbital character of NO_{2}^{-} is able to be described. This study provides the first multi-wavelength NO_{2} anisotropy data, which is shown to be in decent agreement with much earlier zero-core model predictions of the anisotropy parameter. K. J. Reed, A. H. Zimmerman, H. C. Andersen, and J. I. Brauman, J. Chem. Phys. 64, 1368, (1976). doi:10.1063/1.432404 D. Khuseynov, C. C. Blackstone, L. M. Culberson, and A. Sanov, J. Chem. Phys. 141, 124312, (2014). doi:10.1063/1.4896241 W. B. Clodius, R. M. Stehman, and S. B. Woo, Phys. Rev. A. 28, 760, (1983). doi:10.1103/PhysRevA.28.760 Research supported by the Australian Research Council Discovery Project Grant DP160102585

  1. Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Lee JH


    Full Text Available Ji Han Lee,1 Won Sang Jung,2 Woo Hee Choi,3 Hyun Kook Lim4 1Washington University in St Louis, St Louis, MO, USA; 2Department of Radiology, 3Department of Nuclear Medicine, 4Department of Psychiatry, Saint Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, South Korea Objective: Among patients with Alzheimer’s disease (AD, sleep disturbances are common and serious noncognitive symptoms. Previous studies of AD patients have identified deformations in the brain stem, which may play an important role in the regulation of sleep. The aim of this study was to further investigate the relationship between sleep disturbances and alterations in brain stem morphology in AD.Materials and methods: In 44 patients with AD and 40 healthy elderly controls, sleep disturbances were measured using the Neuropsychiatry Inventory sleep subscale. We employed magnetic resonance imaging-based automated segmentation tools to examine the relationship between sleep disturbances and changes in brain stem morphology.Results: Analyses of the data from AD subjects revealed significant correlations between the Neuropsychiatry Inventory sleep-subscale scores and structural alterations in the left posterior lateral region of the brain stem, as well as normalized brain stem volumes. In addition, significant group differences in posterior brain stem morphology were observed between the AD group and the control group.Conclusion: This study is the first to analyze an association between sleep disturbances and brain stem morphology in AD. In line with previous findings, this study lends support to the possibility that brain stem structural abnormalities might be important neurobiological mechanisms underlying sleep disturbances associated with AD. Further longitudinal research is needed to confirm these findings. Keywords: Alzheimer’s disease, sleep, brain stem, MRI, shape analysis

  2. Prevalence of colorectal adenomatous polyps in patients with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Chun EM


    Full Text Available Eun Mi Chun, Seo Woo Kim, So Yeon Lim Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Republic of Korea Background: Colorectal adenomatous polyps are precancerous lesions of colorectal cancer. The aim of this study was to assess the prevalence of colorectal adenomatous polyps in chronic obstructive pulmonary disease (COPD patients and determine whether COPD is associated with colorectal malignant potential.Methods: Subjects who had undergone post-bronchodilator spirometry and colonoscopy and were 40 years or older were selected from the hospital database. COPD was defined as a spirometry in which the ratio of forced expiratory volume in 1 second (FEV1 and forced vital capacity (FVC is <0.7 in post-bronchodilator spirometry. The non-COPD group was matched for both age and sex, and were defined as having an FEV1, FVC, and FEV1/FVC ≥0.7 in spirometry. Finally, 333 patients were retrospectively reviewed; of this group, 82 patients had COPD.Results: Among the subjects, 201 patients (60% were nonsmokers, while 78 (23% were current smokers. The prevalence of colorectal adenomatous polyps was 39% (98/251 in the non-COPD group and 66% (54/82 in the COPD group. Among 54 patients with adenomatous polyps in the COPD group, 47 had tubular adenoma and seven had villous adenoma. Multiple logistic regression analyses revealed that only COPD patients whom matched to the criteria of COPD by pulmonary function test (odds ratio 2.1, 95% confidence interval: 1.1–3.8; P=0.019 were independently associated with colorectal malignant potential.Conclusion: The risk of colorectal malignant potential in the COPD group was higher than in the non-COPD group. We may suggest that COPD patients should consider regular colonoscopic evaluation to screen for premalignant colon polyps regardless of smoking. Keywords: COPD, colorectal adenomatous polyp, smoking, chronic obstructive pulmonary

  3. Committees (United States)


    Leadership Team of the IAHR Committee for Hydraulic Machinery and Systems Eduard EGUSQUIZA, UPC Barcelona, Spain, Chair François AVELLAN, EPFL-LMH, Switzerland, Past Chair Richard K FISHER, Voith Hydro Inc., USA, Past Chair Fidel ARZOLA, Edelca, Venezuela Michel COUSTON, Alstom Hydro, France Niklas DAHLBÄCKCK, Vatenfall, Sweden Normand DESY, Andritz VA TECH Hydro Ltd., Canada Chisachi KATO, University of Tokyo, Japan Andrei LIPEJ, Turboinstitut, Slovenija Torbjørn NIELSEN, NTNU, Norway Romeo SUSAN-RESIGA, 'Politehnica' University Timisoara, Romania Stefan RIEDELBAUCH, Stuggart University, Germany Albert RUPRECHT, Stuttgart University, Germany Qing-Hua SHI, Dong Fang Electrical Machinery Co., China Geraldo TIAGO, Universidade Federal de Itajubá, Brazil International Advisory Committee Shouqi YUAN (principal) Jiangsu University China QingHua SHI (principal) Dong Fang Electrical Machinery Co. China Fidel ARZOLA EDELCA Venezuela Thomas ASCHENBRENNER Voith Hydro GmbH & Co. KG Germany Anton BERGANT Litostroj Power doo Slovenia B C BHAOYAL Research & Technology Centre India Hermod BREKKE NTNU Norway Stuart COULSON Voith Hydro Inc. USA Paul COOPER Fluid Machinery Research Inc USA V A DEMIANOV Power Machines OJSC Russia Bart van ESCH Technische Universiteit Eindhoven Netherland Arno GEHRER Andritz Hydro Graz Austria Akira GOTO Ebara Corporation Japan Adiel GUINZBURG The Boeing Company USA D-H HELLMANN KSB AG Germany Ashvin HOSANGADI Combustion Research and Flow Technology USA Byung-Sun HWANG Korea Institute of Material Science Korea Toshiaki KANEMOTO Kyushu Institute of Technology Japan Mann-Eung KIM Korean Register of Shipping Korea Jiri KOUTNIK Voith Hydro GmbH & Co. KG Germany Jinkook LEE Eaton Corporation USA Young-Ho LEE Korea Maritime University Korea Woo-Seop LIM Hyosung Goodsprings Inc Korea Jun MATSUI Yokohama National University Japan Kazuyoshi Mitsubishi H I Ltd, Japan MIYAGAWA Christophe NICOLET Power Vision Engineering Srl Switzerland Maryse PAGE Hydro

  4. Highlights of Astronomy, Vol. 15 (United States)

    Corbett, Ian


    Preface; Part I. Gruber Cosmology Prize Lecture; Part II. Invited Discourses; Part III. Joint Discussions: 1. Dark matter in early-type galaxies Léon V. E. Koopmans and Tommaso Treu; 2. Diffuse light in galaxy clusters Magda Arnaboldi and Ortwin Gerhard; 3. Neutron stars - timing in extreme environments Tomaso Belloni, Mariano Méndez and Chengmin Zhang; 4. Progress in understanding the physics of Ap and related stars Margarida Cunha; 5. Modelling the Milky Way in the age of Gaia Annie C. Robin; 6. Time and astronomy Pascale Defraigne; 7. Astrophysical outflows and associated accretion phenomena Elisabete M. de Gouveia Dal Pino and Alex C. Raga; 8. Hot interstellar matter in elliptical galaxies Dong-Woo Kim and Silvia Pellegrini; 9. Are the fundamental constants varying with time? Paolo Molaro and Elisabeth Vangioni; 10. 3D views on cool stellar atmospheres - theory meets observation K. N. Nagendra, P. Bonifacio and H. G. Ludwig; 11. New advances in helio- and astero-seismology; 12. The first galaxies - theoretical predictions and observational clues; 13. Eta Carinae in the context of the most massive stars Theodore R. Gull and Augusto Damineli; 14. The ISM of galaxies in the far-infrared and sub-millimetre; 15. Magnetic fields in diffuse media Elisabete M. de Gouveia Dal Pino and Alex Lazarian; 16. IHY global campaign - whole heliosphere interval; Part IV. Special Sessions: SpS 1. IR and sub-mm spectroscopy - a new tool for studying stellar evolution Glenn Wahlgren, Hans Käufl and Florian Kerber; SpS 2. The international year of astronomy Pedro Russo, Catherine Cesarsky and Lars Lindberg Christensen; SpS 3. Astronomy in Antarctica in 2009 Michael G. Burton; SpS 4. Astronomy education between past and future J. P. De Greve; SpS 5. Accelerating the rate of astronomical discovery Ray P. Norris; SpS 6. Planetary systems as potential sites for life Régis Courtin, Alan Boss and Michel Mayor; SpS 7. Young stars, brown dwarfs, and protoplanetary disks Jane Gregorio

  5. Proteinaceous Resin and Hydrophilic Encapsulation: A Self-Healing-Related Study (United States)

    Zheng, Ting

    .g. hydrophilic agent encapsulation, was addressed through the development of novel polyurethane-Poly(melamine-formaldehyde) (PU-PMF) dual-component capsules. Remarkably, the external PU insulation layer was fabricated through interfacial polymerization based on a water-in-oil-in-oil (W/O/O) emulsion template. Surface tension was identified as the main driving factor for the formation of the external oil phase. The internal PMF layer was observed to strongly influence the internal morphology of the capsule. A protocol was developed, and a typical capsule with dense and neat shell morphology with a shell/capsule diameter (around 3 %) was fabricated. This study provides solutions for the two aforementioned obstacles related to the development of the healing system for the protein-based materials.

  6. Effectiveness of elastic band-type ankle–foot orthoses on postural control in poststroke elderly patients as determined using combined measurement of the stability index and body weight-bearing ratio

    Directory of Open Access Journals (Sweden)

    Kim JH


    Full Text Available Jong Hyun Kim, Woo Sang Sim, Byeong Hee Won Usability Evaluation Technology Center, Advanced Biomedical and Welfare R&D Group, Korea Institute of Industrial Technology, Cheonan-si, Chungcheongnam-do, South Korea Purpose: Poor recovery of postural stability poststroke is the primary cause of impairment in activities and social participation in elderly stroke survivors. The purpose of our study was to experimentally evaluate the effectiveness of our new elastic ankle–foot orthosis (AFO, compared to a traditional AFO fabricated with hard plastic, in improving postural stability in elderly chronic stroke survivors. Patients and methods: Postural stability was evaluated in ten chronic stroke patients, 55.7±8.43 years old. Postural stability was evaluated using the standardized methods of the Biodex Balance System combined with a foot pressure system, under three experimental conditions, no AFO, rigid plastic AFO, and elastic AFO (E-AFO. The following dependent variables of postural stability were analyzed: plantar pressure under the paretic and nonparetic foot, area of the center of balance (COB and % time spent in each location, distance traveled by the COB away from the body center, distance traveled by the center of pressure, and calculated index of overall stability, as well as indices anterior–posterior and medial–lateral stability. Results: Both AFO designs improved all indices of postural stability. Compared to the rigid plastic AFO, the E-AFO produced additional positive effects in controlling anterior–posterior body sway, equalizing weight bearing through the paretic and nonparetic limbs, and restraining the displacement of the center of pressure and of the COB. Conclusion: Based on our outcomes, we recommend the prescription of E-AFOs as part of a physiotherapy rehabilitation program to promote recovery of postural stability poststroke. When possible, therapeutic outcomes should be documented using the Biodex Balance System and

  7. Eyes wide open: reader and author responsibility in understanding the limits of peer review. (United States)

    Benson, P J


    'Medical science can only flourish in a free society and dies under totalitarian repression.' (1) Peer review post-publication is relatively easy to define: when the world decides the importance of publication. Peer review pre-publication is what the scientific community frequently means when using the term 'peer review'. But what it is it? Few will agree on an exact definition; generally speaking, it refers to an independent, third party scrutiny of a manuscript by scientific experts (called peers) who advise on its suitability for publication. Peer review is expensive; although reviewers are unpaid, the cost in time is enormous and it is slow. There is often little agreement among reviewers about whether an article should be published and peer review can be a lottery. Often referred to as a quality assurance process, there are many examples of when peer review failed. Many will be aware of Woo-Suk Hwang's shocking stem cell research misconduct at Seoul National University. (2) Science famously published two breakthrough articles that were found subsequently to be completely fabricated and this happened in spite of peer review. Science is not unique in making this error. However, love it or hate it, peer review, for the present time at least, is here to stay. In this article, Philippa Benson, Managing Editor of Science Advances (the first open access journal of the American Association for the Advancement of Science), discusses the merits of peer review. Dr Benson has extensive experience in the publishing world and was Executive Director of PJB Consulting, a not-for-profit organisation supporting clients on issues related to converting to full electronic publishing workflows as well as challenges working with international authors and publishers. Her clients included the Public Library of Science journals, the American Society for Nutrition and the de Beaumont Foundation. She recently co-authored a book, What Editors Want: An Author's Guide to Scientific Journal

  8. A Chinese Chan-based mind–body intervention improves psychological well-being and physical health of community-dwelling elderly: a pilot study

    Directory of Open Access Journals (Sweden)

    Yu R


    Full Text Available Ruby Yu,1 Jean Woo,1 Agnes S Chan,2–4 Sophia L Sze2,3 1Department of Medicine and Therapeutics, 2Department of Psychology, 3Chanwuyi Research Center for Neuropsychological Well-Being, The Chinese University of Hong Kong, New Territories, Hong Kong; 4Henan Songshan Research Institute for Chanwuyi, Henan, People's Republic of China Background: The aim of this study was to explore the potential benefits of the Dejian mind–body intervention (DMBI for psychological and physical health in older Chinese adults. Methods: After confirmation of eligibility, the subjects were invited to receive DMBI once a week for 12 weeks. The intervention involved components of learning self-awareness and self-control, practicing mind–body exercises, and adopting a special vegetarian diet. Intervention-related changes were measured using the Perceived Stress Scale, Geriatric Depression Scale, Pittsburgh Sleep Quality Index, Chinese Constipation Questionnaire, and self-report ratings of health. Indicators of metabolic syndrome and walking speed were also measured. Results: Of the 44 subjects recruited, 42 (54.8% men completed the study, giving an adherence rate of 95%. There was a significant reduction in perceived stress (P<0.05. A significant improvement was also found in systolic blood pressure among those who had abnormally high blood pressure at baseline (P<0.05. Physical fitness as reflected by walking speed was also significantly increased after the intervention (P<0.05. Sleep disturbances were reduced (P<0.01. Self-rated health was significantly enhanced, with the percentage rating very good health increasing from 14.3% at baseline to 42.8% after the intervention (P<0.001. No intervention effect was found for waist circumference, lipids and fasting blood glucose levels, Pittsburgh Sleep Quality Index global score, and constipation measures. Conclusion: The DMBI was feasible and acceptable, and subjects showed some improvements in psychological and physical

  9. In vivo gastric residence and gastroprotective effect of floating gastroretentive tablet of DA-9601, an extract of Artemisia asiatica, in beagle dogs

    Directory of Open Access Journals (Sweden)

    Kim JS


    Full Text Available Jeong Soo Kim,1 Kwang Ho Cha,1 Seung Yeob Kang,1 Donghan Won,1 Sun Woo Jang,1 Miwon Son,1 Moon Ho Son,1 Ho Jung Choi,2 Young Won Lee,2 Myung Joo Kang3 1Dong-A Pharmaceutical Co. Ltd., Giheung-gu, Yongin, Gyeonggi, 2College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungnam National University, Daejeon, 3College of Pharmacy, Dankook University, Dongnam-gu, Cheonan, Chungnam, South Korea Objective: DA-9601, an extract of Artemisia asiatica containing eupatilin and jaceosidin as active compounds, has been prescribed to treat gastritis in Asia. In recent times, sustained-release, floating gastroretentive (GR tablets of DA-9601 are available on the market. In the present study, the physical properties and in vitro drug release profile, in vivo gastric residence time, and gastroprotective effect of GR tablet were compared to those of immediate release (IR tablets of DA-9601.Method: In vitro buoyancy behavior (floating lag time and duration and release profile of eupatilin were assessed in acidic medium. The in vivo intragastric behaviors of the barium sulfate-loaded IR and GR tablets were evaluated in beagle dogs by radiographic studies. Local gastroprotective effect was compared in an experimentally induced gastric lesion in beagle dogs after oral administration of IR (three times per day or GR (twice daily tablets for 15 days.Results: Upon contact with gastric juice, a low-density floating tablet (apparent density of 0.93 g/cm3 was buoyant on the medium and was upheld for 14 hours, providing sustained drug release profile, whereas the IR tablet disintegrated within 10 minutes, showing complete drug release within 2 hours. In vivo radiographic studies showed that the GR tablet was retained for >4 hours in the stomach. Both DA-9601 formulations remarkably alleviated gastric mucosal injury compared to placebo group, when observed by gastric endoscopy.Conclusion: Twice-daily GR tablets exhibited a prolonged gastric residence

  10. RESOLVE Project (United States)

    Parker, Ray O.


    The RESOLVE project is a lunar prospecting mission whose primary goal is to characterize water and other volatiles in lunar regolith. The Lunar Advanced Volatiles Analysis (LAVA) subsystem is comprised of a fluid subsystem that transports flow to the gas chromatograph- mass spectrometer (GC-MS) instruments that characterize volatiles and the Water Droplet Demonstration (WDD) that will capture and display water condensation in the gas stream. The LAVA Engineering Test Unit (ETU) is undergoing risk reduction testing this summer and fall within a vacuum chamber to understand and characterize C!Jmponent and integrated system performance. Ray will be assisting with component testing of line heaters, printed circuit heaters, pressure transducers, temperature sensors, regulators, and valves in atmospheric and vacuum environments. He will be developing procedures to guide these tests and test reports to analyze and draw conclusions from the data. In addition, he will gain experience with preparing a vacuum chamber with fluid and electrical connections. Further testing will include integrated testing of the fluid subsystem with the gas supply system, near-infrared spectrometer, WDD, Sample Delivery System, and GC-MS in the vacuum chamber. This testing will provide hands-on exposure to a flight forward spaceflight subsystem, the processes associated with testing equipment in a vacuum chamber, and experience working in a laboratory setting. Examples of specific analysis Ray will conduct include: pneumatic analysis to calculate the WOO's efficiency at extracting water vapor from the gas stream to form condensation; thermal analysis of the conduction and radiation along a line connecting two thermal masses; and proportional-integral-derivative (PID) heater control analysis. In this Research and Technology environment, Ray will be asked to problem solve real-time as issues arise. Since LAVA is a scientific subsystem, Ray will be utilizing his chemical engineering background to

  11. Can short-term residential care for stroke rehabilitation help to reduce the institutionalization of stroke survivors?

    Directory of Open Access Journals (Sweden)

    Chau PH


    Full Text Available Pui Hing Chau,1 Maria WS Tang,2 Fannie Yeung,2 Tsz Wai Chan,1 Joanna OY Cheng,1 Jean Woo2 1School of Nursing, University of Hong Kong, Hong Kong, Special Administrative Region of the People's Republic of China; 2Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, Special Administrative Region of the People's Republic of China Background: Stroke survivors may not be receiving optimal rehabilitation as a result of a shortage of hospital resources, and many of them are institutionalized. A rehabilitation program provided in a short-term residential care setting may help to fill the service gap. Objectives: The primary objectives of this study were, first, to examine whether there were significant differences in terms of rehabilitation outcomes at 1 year after admission to the rehabilitation program (defined as baseline between those using short-term residential care (intervention group and those using usual geriatric day hospital care (control group, and, second, to investigate whether lower 1-year institutionalization rates were observed in the intervention group than in the control group. Participants: 155 stroke survivors who completed at least the first follow-up at 4 months after baseline. Intervention: The intervention group was stroke survivors using self-financed short-term residential care for stroke rehabilitation. The control group was stroke survivors using the usual care at a public geriatric day hospital. Measurements: Assessments were conducted by trained research assistants using structured questionnaires at baseline, 4 months, and 1 year after baseline. The primary outcome measures included Modified Barthel Index score, Mini-Mental Status Examination score, and the institutionalization rate. Results: Cognitive status (as measured by Mini-Mental Status Examination score of patients in both groups could be maintained from 4 months to 1 year, whereas functional status (as measured by Modified Barthel

  12. Analysis of Factors Controlling Cell Cycle that Can Be Synchronized Nondestructively During Root Cap Development

    Energy Technology Data Exchange (ETDEWEB)

    Hawes, Martha


    Publications and presentations during the final funding period, including progress in defining the substrate specificity, the primary goal of the project, are listed below. Both short-term and long-term responses mediated by PsUGT1 have been characterized in transgenic or mutant pea, alfalfa, and Arabidopsis with altered expression of PsUGT1. Additional progress includes evaluation of the relationship between control of the cell cycle by PsUGT1 and other glycosyltransferase and glycosidase enzymes that are co-regulated in the legume root cap during the onset of mitosis and differentiation. Transcriptional profiling and multidimensional protein identification technology ('MudPIT') have been used to establish the broader molecular context for the mechanism by which PsUGT1 controls cell cycle in response to environmental signals. A collaborative study with the Norwegian Forest Research Institute (who provided $10,000.00 in supplies and travel funds for collaborator Dr. Toril Eldhuset to travel to Arizona and Dr. H. H. Woo to travel to Norway) made it possible to establish that the inducible root cap system for studying carbohydrate synthesis and solubilization is expressed in gymnosperm as well as angiosperm species. This discovery provides an important tool to amplify the potential applications of the research in defining conserved cell cycle machinery across a very broad range of plant species and habitats. The final work, published during 2009, revealed an additional surprising parallel with mammalian immune responses: The cells whose production is controlled by PsUGT1 appear to function in a manner which is analogous to that of white blood cells, by trapping and killing in an extracellular manner. This may explain why mutation within the coding region of PsUGT1 and its homolog in humans (UGT1) is lethal to plants and animals. The work has been the subject of invited reviews. A postdoctoral fellow, eight undergraduate students, four M.S. students and

  13. Effect of triptorelin on lower urinary tract symptoms in Australian prostate cancer patients

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    Woo HH


    Full Text Available Henry H Woo,1 Declan G Murphy,2,3 Gerard M Testa,4 Jeremy P Grummet,5 Michael Chong,6 Andrew P Stork7 1Sydney Adventist Hospital Clinical School, University of Sydney, Wahroonga, NSW, 2Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, VIC, 3Australian Prostate Cancer Research Centre, Epworth Healthcare, Richmond, VIC, 4Shire Urology, Miranda, NSW, 5Australian Urology Associates, Malvern, VIC, 6Department of Urology, Repatriation General Hospital, Daw Park, SA, 7Ipsen Pty Ltd, Glen Waverley, VIC, Australia Purpose: Prostate cancer is often comorbidly associated with lower urinary tract symptoms (LUTS, but few studies have assessed the effects of androgen deprivation therapy on LUTS in this patient group.Patients and methods: We conducted a prospective, noninterventional, multicenter, observational study to assess the effectiveness of triptorelin (11.25 mg every 12 weeks over 48 weeks in men presenting with local stage T3/4 prostate cancer and moderate to severe LUTS (International Prostate Symptom Score [IPSS] >7 in a routine practice setting in Australia.Results: Of the 44 men who enrolled, effectiveness data were available for 39 men. By the end of the study, 30% of men no longer met the IPSS criteria for moderate to severe LUTS. The proportion of patients with moderate to severe LUTS was 69.6% (16/23 at week 48 and 76.9% (30/39 at the last available visit (coprimary outcomes. An IPSS reduction of ≥3 from week 0 was observed in 47% of men at week 4, 56% at week 24, 61% (14/23 at week 48, and 61.5% (24/39 at the last available visit. Quality of life was rated as mostly satisfied-to-delighted by 39.5% of patients at week 0, 53.9% at week 24, and 77.3% at week 48. Triptorelin was well tolerated with 8 treatment-related adverse events reported, half of which were hot flushes; 5 patients discontinued due to the reported treatment-related adverse events.Conclusion: This observational study suggests that triptorelin improves


    Directory of Open Access Journals (Sweden)

    K. V. Dobrego


    Full Text Available Various aerodynamic design elements and technics (wind deflectors, wind walls, etc. are utilized for improvement of the thermal efficiency of the natural draft cooling towers, particularly in conditions of cross wind. One of the technical methods, proposed by engineers of Belarus Academy of Sciences, is installation of the ventilation window in the center of the fill. This method is substantiated by the fact that the flow of cooling gas obtains maximum temperature and humidity near the center of the under-fill space of cooling tower and, as a consequence, performs minimal heat exchange. The influence of the fill ventilation window and wind deflectors in the inlet windows of the cooling tower on its thermal performance in condition of cross-wind is investigated in the paper numerically. The cooling tower of the “Woo-Jin” power plant (China 150 m of the height and 114 m of the base diameter was taken as a prototype. The analogy (equivalence between the heat and mass transfer was taken into consideration, which enabled us to consider single-phase flow and perform complicated 3D simulation by using modern personal computers. Heat transfer coefficient for the fill and its hydrodynamic resistance were defined by using actual data on total flow rate in the cooling tower. The numerical model and computational methods were tested and verified in numerous previous works. The non-linear dependence of the thermal performance of the cooling tower on wind velocity (with the minimum in vicinity of Ucr ~ 8 m/s for the simulated system was demonstrated. Calculations show that in the condition of the average wind speed the fill ventilation window doesn’t improve, but slightly decrease (by 3–7 % performance of the cooling tower. Situation changes in the condition of strong winds Ucw > 12 m/s, which are not typical for Belarus. Utilization of airflow deflectors at the inlet windows of cooling tower, conversely, increases thermal performance of the

  15. Process-based hydrological modeling using SWAT: The effect of permafrost on water resources in the large-scale river catchment Kharaa / Mongolia (United States)

    Hülsmann, L.; Geyer, T.; Karthe, D.; Priess, J.; Schweitzer, C.


    In this study, the Soil Water Assessment Tool (SWAT) was applied to obtain a better understanding of hydrological processes in the semi-arid catchment of the Kharaa River in Northern Mongolia. The transient, physical-based model SWAT was set up using spatial datasets on soil, land use, climate, and stream network provided by the project "IWRM-MoMo" to (i.) simulate the water balance components of the basin and (ii.) to identify potential gaps in the input data. We found that the SWAT model satisfactorily reflects the hydrological processes in the catchment and simulates river runoff as a response to strong rainfall events as well as to snow and ice melt. To obtain correct runoff volumes during spring, permafrost has to be considered. Permafrost-influenced soils constrain water flow in the frozen layer, so that percolation out of the active layer is hampered (Woo 2011). This effect is reproduced in SWAT by assigning an impermeable layer in the subsurface to the areas dominated by permafrost. The simulations indicate that in these regions groundwater resources are limited as a consequence of impermeable ground ice. In addition, groundwater recharge rates in the catchment are generally low due to high evaporation rates (80-90 %). Consequently the base flow contribution is small. Further studies on the estimation of groundwater recharge rates should be carried out, since groundwater is an important resource for water supply. Model results indicate that the non-uniformity of the precipitation distribution was not sufficiently covered by the interpolated input data, so that precipitation and runoff volumes are partially over- or underestimated. Since precipitation defines the overall water availability in river catchments (Baumgartner 1982), additional climate records would considerably improve model outputs. As a consequence of large evapotranspiration losses, discharge as well as groundwater recharge estimates were identified to be highly sensitive to

  16. Agricultural Fragility Estimates Subjected to Volcanic Ash Fall Hazards (United States)

    Ham, H. J.; Lee, S.; Choi, S. H.; Yun, W. S.


    Agricultural Fragility Estimates Subjected to Volcanic Ash Fall Hazards Hee Jung Ham1, Seung-Hun Choi1, Woo-Seok Yun1, Sungsu Lee2 1Department of Architectural Engineering, Kangwon National University, Korea 2Division of Civil Engineering, Chungbuk National University, Korea ABSTRACT In this study, fragility functions are developed to estimate expected volcanic ash damages of the agricultural sector in Korea. The fragility functions are derived from two approaches: 1) empirical approach based on field observations of impacts to agriculture from the 2006 eruption of Merapi volcano in Indonesia and 2) the FOSM (first-order second-moment) analytical approach based on distribution and thickness of volcanic ash observed from the 1980 eruption of Mt. Saint Helens and agricultural facility specifications in Korea. Fragility function to each agricultural commodity class is presented by a cumulative distribution function of the generalized extreme value distribution. Different functions are developed to estimate production losses from outdoor and greenhouse farming. Seasonal climate influences vulnerability of each agricultural crop and is found to be a crucial component in determining fragility of agricultural commodities to an ash fall. In the study, the seasonality coefficient is established as a multiplier of fragility function to consider the seasonal vulnerability. Yields of the different agricultural commodities are obtained from Korean Statistical Information Service to create a baseline for future agricultural volcanic loss estimation. Numerically simulated examples of scenario ash fall events at Mt. Baekdu volcano are utilized to illustrate the application of the developed fragility functions. Acknowledgements This research was supported by a grant 'Development of Advanced Volcanic Disaster Response System considering Potential Volcanic Risk around Korea' [MPSS-NH-2015-81] from the Natural Hazard Mitigation Research Group, Ministry of Public Safety and Security of

  17. Postoperative pain and patient-controlled epidural analgesia-related adverse effects in young and elderly patients: a retrospective analysis of 2,435 patients

    Directory of Open Access Journals (Sweden)

    Koh JC


    Full Text Available Jae Chul Koh, Young Song, So Yeon Kim, Sooyeun Park, Seo Hee Ko, Dong Woo Han Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, South Korea Abstract: In this retrospective study, data of 2,435 patients who received fentanyl and ropivacaine-based patient-controlled epidural analgesia (PCEA for pain relief after elective surgery under general or spinal anesthesia were reviewed. Differences in postoperative pain, incidence of patient-controlled analgesia (PCA-related adverse effects, and risk factors for the need for rescue analgesics for 48 hours postsurgery in young (age 20–39 years and elderly (age ≥70 years patients were evaluated. Although there were no significant differences in postoperative pain intensity between the two groups until 6 hours postsurgery, younger patients experienced greater postoperative pain intensity compared with older patients 6–48 hours postsurgery. While younger patients exhibited greater incidence of numbness, motor weakness, and discontinuation of PCA postsurgery, elderly patients exhibited greater incidence of hypotension, nausea/vomiting, rescue analgesia, and antiemetic administration. Upon multivariate analysis, low fentanyl dosage and history of smoking were found to be associated with an increased need for rescue analgesia among younger patients, while physical status classification III/IV and thoracic surgery were associated with a decreased need for rescue analgesia among the elderly. Discontinuation of PCA was more frequent among younger patients than the elderly (18.5% vs 13.5%, P=0.001. Reasons for discontinuation of PCA among young and elderly patients, respectively, were nausea and vomiting (6.8% vs 26.6%, numbness or motor weakness (67.8% vs 11.5%, urinary retention (7.4% vs 8.7%, dizziness (2.2% vs 5.2%, and hypotension (3.1% vs 20.3%. In conclusion, PCEA was more frequently associated with numbness, motor

  18. Randomized controlled trials – a matter of design

    Directory of Open Access Journals (Sweden)

    Spieth PM


    Full Text Available Peter Markus Spieth,1,2 Anne Sophie Kubasch,3 Ana Isabel Penzlin,4 Ben Min-Woo Illigens,2,5 Kristian Barlinn,6 Timo Siepmann2,6,7 1Department of Anesthesiology and Critical Care Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, 2Center for Clinical Research and Management Education, Division of Health Care Sciences, Dresden International University, 3Pediatric Rheumatology and Immunology, Children’s Hospital, University Hospital Carl Gustav Carus, Technische Universität Dresden, 4Institute of Clinical Pharmacology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Saxony, Germany; 5Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; 6Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Saxony, Germany; 7Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, Oxfordshire, UK Abstract: Randomized controlled trials (RCTs are the hallmark of evidence-based medicine and form the basis for translating research data into clinical practice. This review summarizes commonly applied designs and quality indicators of RCTs to provide guidance in interpreting and critically evaluating clinical research data. It further reflects on the principle of equipoise and its practical applicability to clinical science with an emphasis on critical care and neurological research. We performed a review of educational material, review articles, methodological studies, and published clinical trials using the databases MEDLINE, PubMed, and The most relevant recommendations regarding design, conduction, and reporting of RCTs may include the following: 1 clinically relevant end points should be defined a priori, and an unbiased analysis and report of the study results should be warranted, 2 both significant and nonsignificant results should be objectively

  19. Primary care for diabetes mellitus: perspective from older patients

    Directory of Open Access Journals (Sweden)

    Wong ELY


    Full Text Available Eliza Lai Yi Wong1, Jean Woo2, Elsie Hui3, Carrie Chan2, Wayne LS Chan2, Annie Wai Ling Cheung11School of Public Health and Primary Care, The Chinese University of Hong Kong, 2School of Public Health and Primary Care, Division of Geriatrics, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, 3Medical and Geriatric Unit, Shatin Hospital, HK SAR, Hong Kong, People’s Republic of ChinaBackground: Care of diabetes mellitus in the elderly requires an additional perspective to take into account impaired cognitive function, physical function, low level of education, and difficulty making lifestyle changes. Existing services tend to be driven by the views of tertiary and secondary care staff, rather than those of primary care staff and elderly patients. This study aimed to explore the attitudes and preferences of elderly patients with diabetes mellitus towards primary care (clinical care and community program.Method: Elderly patients with diabetes mellitus aged 60 years or above were recruited from governmental diabetes mellitus clinics and diabetes mellitus specific community centers. Three focus group discussions of 14 diabetic elderly patients were conducted and their perspectives on the new service model were assessed. Participants were interviewed according to an open-ended discussion guide which includes the following items: comments on existing clinic follow up and community program, motivation for joining the community program, and suggestions on further clinical services and community service program development.Results: Incapability of the current health service to address their special needs was a common concern in three focus group discussions. The majority highlighted the benefits of the new service program, that is, self-care knowledge and skill, attitudes to living with diabetes mellitus, and supportive network. Key facilitators included experiential learning, a group discussion platform

  20. Risk factors for chronic obstructive pulmonary disease among never-smokers in Korea

    Directory of Open Access Journals (Sweden)

    Lee SJ


    Full Text Available Seok Jeong Lee,1 Seo Woo Kim,1 Kyoung Ae Kong,2 Yon Ju Ryu,1 Jin Hwa Lee,1 Jung Hyun Chang1 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, 2Department of Clinical Trial Center, School of Medicine, Ewha Womans University, Seoul, Republic of Korea Background: Chronic obstructive pulmonary disease (COPD patients include those who have never smoked. However, risk factors other than smoking in never-smokers have not been elucidated sufficiently. This study investigated the risk factors for COPD among never-smokers in Korea using population-based data. Methods: The data were retrieved from the Korean National Health and Nutrition Survey IV conducted from 2007 to 2009. Among subjects aged 40 years or older who underwent appropriate pulmonary function tests, never-smokers not diagnosed with asthma and not showing a restrictive pattern on pulmonary function tests were enrolled. Risk factors of COPD in never-smokers were analyzed using logistic regression models. Results: Among 24,871 participants in the representative Korean cohort, 3,473 never-smokers were enrolled. COPD patients accounted for 7.6% of the never-smokers. In the logistic regression analysis, low education status (odds ratio [OR]: 2.0; 95% confidence interval [CI]: 1.2–3.2, occupational exposure (OR: 2.6; 95% CI: 1.3–5.3, a history of tuberculosis (OR: 4.5; 95% CI: 2.3–8.7, bronchiectasis (OR: 6.0; 95% CI: 1.4–25.4, male sex (OR: 4.2; 95% CI: 2.6–6.7, advanced age (60–69 years vs 40–49 years; OR: 3.8; 95% CI: 2.0–7.0, and being underweight (body mass index <18.5 vs 18.0–24.9 kg/m2; OR: 3.1; 95% CI: 1.0–9.4 were associated with the development of COPD. Conclusion: Low education status, manual labor, a history of tuberculosis and bronchiectasis, as well as male sex, advanced age and being underweight were risk factors for COPD in Korean never-smokers. Keywords: socioeconomic status, chronic obstructive pulmonary disease, never-smoker

  1. Recruited renin-containing renal microvascular cells demonstrate the calcium paradox regulatory phenotype

    Directory of Open Access Journals (Sweden)

    MacGriff S


    Full Text Available Spencer MacGriff,1 Richard E Woo,1 M Cecilia Ortiz-Capisano,1 Douglas K Atchison,1,2 William H Beierwaltes1,2 1Department of Internal Medicine, Hypertension and Vascular Research Division, Henry Ford Hospital, 2Department of Physiology, Wayne State University School of Medicine, Detroit, MI, USA Abstract: Renin is the critical regulatory enzyme for production of angiotensin (Ang-II, a potent vasoconstrictor involved in regulating blood pressure and in the pathogenesis of hypertension. Chronic sodium deprivation enhances renin secretion from the kidney, due to recruitment of additional cells from the afferent renal microvasculature to become renin-producing rather than just increasing release from existing juxtaglomerular (JG cells. JG cells secrete renin inversely proportional to extra- and intracellular calcium, a unique phenomenon characteristic of the JG regulatory phenotype known as the “calcium paradox.” It is not known if renin secreted from recruited renin-containing cells is regulated similarly to native JG cells, and therefore acquires this JG cell phenotype. We hypothesized that non-JG cells in renal microvessels recruited to produce renin in response to chronic dietary sodium restriction would demonstrate the calcium paradox, characteristic of the JG cell phenotype. Histology showed recruitment of upstream arteriolar renin in response to sodium restriction compared to normal-diet rats. Renin fluorescence intensity increased 53% in cortices of sodium-restricted rats (P<0.001. We measured renin release from rat afferent microvessels, isolated using iron oxide nanopowder and incubated in either normal or low-calcium media. Basal renin release from normal sodium-diet rat microvessels in normal calcium media was 298.1±44.6 ng AngI/mL/hour/mg protein, and in low-calcium media increased 39% to 415.9±71.4 ng AngI/mL/hour/mg protein (P<0.025. Renin released from sodium-restricted rat microvessels increased 50% compared to samples from

  2. The effect of dietary antioxidant on the COPD risk: the community-based KoGES (Ansan–Anseong cohort

    Directory of Open Access Journals (Sweden)

    Joshi P


    Full Text Available Pankaj Joshi,1,2 Woo Jin Kim,3,4 Sang-Ah Lee1–3 1Department of Preventive Medicine, 2BIT Medical Convergence Graduate Program, 3Department of Internal Medicine, 4Environmental Health Center, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do, South Korea Background: Dietary antioxidants have been suggested to have protective role against chronic obstructive pulmonary disease (COPD, but few prospective studies examined this relationship. The prospective study was conducted to evaluate the effect of dietary antioxidants on COPD risk and lung function in the Korean population.Methods: The data were collected from the community-based Korean Genome Epidemiology Study (KoGES cohort. To diagnose COPD, forced expiratory volume (FEV1 and forced vital capacity (FVC were measured by spirometry. The dietary intake of antioxidant vitamins was estimated from validated Food-Frequency Questionnaire. For the analysis, 325 COPD patients and 6,781 at risk subjects were selected from the cohort of 10,038 subjects. Multiple logistic regression models were used to examine the odds ratio (OR after adjusting for age, sex, marital status, income, history of asthma, history of tuberculosis, and smoking.Results: The risk of COPD was positively associated with aging, low education, low household income, lower body mass index, and cigarette smoking. The risk of COPD decreased with increase in the dietary vitamin C (ORQ1 vs Q5=0.66, Ptrend=0.03 and vitamin E (ORQ1 vs Q5=0.56, Ptrend=0.05 intake, predominantly, in men (Ptrend=0.01 and 0.05 for vitamins C and E, respectively. In addition, the lung function was significantly improved with increase in vitamins C (FEV1, P=0.04; FVC, P=0.03 and E (FEV1, P=0.03; FVC, P=0.04 intake. No statistically significant interactions were observed between smoking and vitamin C or E intake in relation to COPD risk among men.Conclusion: Our results suggest the independent beneficial effect of antioxidants, particularly

  3. Testing geopressured geothermal reservoirs in existing wells: Detailed completion prognosis for geopressured-geothermal well of opportunity, prospect #2

    Energy Technology Data Exchange (ETDEWEB)



    A geopressured-geothermal test of Martin Exploration Company's Crown Zellerbach Well No. 2 will be conducted in the Tuscaloosa Trend. The Crown Zellerbach Well No. 1 will be converted to a saltwater disposal well for disposal of produced brine. The well is located in the Satsuma Area, Livingston parish, Louisiana. Eaton proposes to test the Tuscaloosa by perforating the 7 inch casing from 16,718 feet to 16,754 feet. The reservoir pressure at an intermediate formation depth of 16,736 feet is anticipated to be 12,010 psi and the temperature is anticipated to be 297 F. Calculated water salinity is 16,000 ppm. The well is expected to produce a maximum of 16,000 barrels of water a day with a gas content of 51 SCF/bbl. Eaton will re-enter the test well, clean out to 17,000 feet, run production casing and complete the well. The disposal well will be re-entered and completed in the 9-5/8 inch casing for disposal of produced brine. Testing will be conducted similar to previous Eaton annular flow WOO tests. An optional test from 16,462 feet to 16,490 feet may be performed after the original test and will require a workover with a rig on location to perform the plugback. The surface production equipment utilized on previous tests will be utilized on this test. The equipment has worked satisfactorily and all parties involved in the testing are familiar with its operation. Weatherly Engineering will operate the test equipment. The Institute of Gas Technology (IGT) and Mr. Don Clark will handle sampling, testing and reservoir engineering evaluation, respectively. wireline work required will be awarded on basis of bid evaluation. At the conclusion of the test period, the D.O.E. owned test equipment will be removed from the test site, the test and disposal wells plugged and abandoned and the sites restored to the satisfaction of all parties.

  4. Tipificación molecular por PCR-RFLPS de cepas trypanosoma sp. aisladas en campo y evaluación de ganados de la Orinoquia colombiana

    Directory of Open Access Journals (Sweden)

    Vera Víctor Julio


    Full Text Available En este estudio se presentan los primeros resultados obtenidos al utilizar como una herramienta diagnóstica,
    técnicas moleculares de PCR y RFLPs sobre la subunidad ribosomal 18S del DNA del Trypanosoma. La PCR-RFLPs
    se estandarizó al utilizar tres cepas de Trypanosoma (Trypanosoma vivax, Trypanosoma evansi y Trypanosoma theileri pertenecientes al Banco de Germoplasma de Hemoparásitos de Corpoica, las cuales fueron multiplicadas en ovinos de lana y purificadas por medio del método de cromatografía de intercambio iónico. Con la PCR semianidada se obtuvieron los primeros amplificados de las tres cepas de Trypanosoma entre 700 a 800 pb, y de 600 a 700 pb en la segunda amplificación. Usando las enzimas de digestión MspI y Eco57I se obtuvieron diferentes perfiles diferenciando las infecciones por Trypanosoma vivax, Trypanosoma evansi y Trypanosoma theileri. Con base en la información obtenida con las tres cepas de Tripanosoma, se trabajaron 70 muestras de sangre de ganados del piedemonte llanero, colectadas por el método del Buffy coat, los cuales fueron reportados como negativos a Trypanosoma bajo pruebas parasitológicas de Woo y extendido de sangre. De las 70 muestras bovinas, con la PCR se detectaron como animales positivos a trypanosoma un 7,14%, con niveles de sensibilidad en campo de la prueba de 25 trypanosomas/ml de sangre parasitada. De los animales positivos, los patrones de digestión obtenidos
    correspondieron a la cepa Trypanosoma theileri en un 80%, y un 20% a la cepa Trypanosoma vivax. Los resultados que se obtuvieron del estudio morfométrico en las especies T. vivax y T. evansi del Banco de Germoplasma de Corpoica, mostraron que el T. vivax es un parásito con mayor longitud (20-25 μm que el T. evansi (18-19 μm, aunque el flagelo libre de este último siempre fue mayor (7-9 μm al igual que el diámetro de su núcleo. En ambos parásitos la posición del núcleo fue central y la posición del quinetolasto

  5. Evaluating Dermatology Residency Program Websites. (United States)

    Ashack, Kurt A; Burton, Kyle A; Soh, Jonathan M; Lanoue, Julien; Boyd, Anne H; Milford, Emily E; Dunnick, Cory; Dellavalle, Robert P


    Internet resources play an important role in how medical students access information related to residency programs.Evaluating program websites is necessary in order to provide accurate information for applicants and provide information regarding areas of website improvement for programs. To date, dermatology residency websites (D  WS) have not been evaluated.This paper evaluates dermatology residency websites based on availability of predefined measures. Using the FREIDA (Fellowship and Residency Electronic Interactive Database) Online database, authors searched forall accredited dermatology program websites. Eligible programs were identified through the FREIDA Online database and had a functioning website. Two authors independently extracted data with consensus or third researcher resolution of differences. This data was accessed and archived from July 15th to July 17th, 2015.Primary outcomes measured were presence of content on education, resident and faculty information, program environment, applicant recruitment, schedule, salary, and website quality evaluated using an online tool ( Out of 117 accredited dermatology residencies, 115 had functioning webpages. Of these, 76.5% (75) had direct links found on the FRIEDA Online database. Most programs contained information on education, faculty, program environment, and applicant recruitment. However, website quality and marketing effectiveness were highly variable; most programs were deemed to need improvements in the functioning of their webpages. Also, additional information on current residents and about potential away rotations were lacking from most websites with only 52.2% (60) and 41.7% (48) of programs providing this content, respectively. A majority of dermatology residency websites contained adequate information on many of the factors we evaluated. However, many were lacking in areas that matter to applicants. We hope this report will encourage dermatology residencyprograms

  6. Vibronic coupling in the superoxide anion: the vibrational dependence of the photoelectron angular distribution. (United States)

    Van Duzor, Matthew; Mbaiwa, Foster; Wei, Jie; Singh, Tulsi; Mabbs, Richard; Sanov, Andrei; Cavanagh, Steven J; Gibson, Stephen T; Lewis, Brenton R; Gascooke, Jason R


    We present a comprehensive photoelectron imaging study of the O(2)(X  (3)Σ(g)(-),v(')=0-6)←O(2)(-)(X  (2)Π(g),v(")=0) and O(2)(a (1)Δ(g),v(')=0-4)←O(2)(-)(X  (2)Π(g),v(")=0) photodetachment bands at wavelengths between 900 and 455 nm, examining the effect of vibronic coupling on the photoelectron angular distribution (PAD). This work extends the v(')=1-4 data for detachment into the ground electronic state, presented in a recent communication [R. Mabbs, F. Mbaiwa, J. Wei, M. Van Duzor, S. T. Gibson, S. J. Cavanagh, and B. R. Lewis, Phys. Rev. A 82, 011401(R) (2010)]. Measured vibronic intensities are compared to Franck-Condon predictions and used as supporting evidence of vibronic coupling. The results are analyzed within the context of the one-electron, zero core contribution (ZCC) model [R. M. Stehman and S. B. Woo, Phys. Rev. A 23, 2866 (1981)]. For both bands, the photoelectron anisotropy parameter variation with electron kinetic energy, β(E), displays the characteristics of photodetachment from a d-like orbital, consistent with the π(g)(∗) 2p highest occupied molecular orbital of O(2)(-). However, differences exist between the β(E) trends for detachment into different vibrational levels of the X  (3)Σ(g)(-) and a (1)Δ(g) electronic states of O(2). The ZCC model invokes vibrational channel specific "detachment orbitals" and attributes this behavior to coupling of the electronic and nuclear motion in the parent anion. The spatial extent of the model detachment orbital is dependent on the final state of O(2): the higher the neutral vibrational excitation, the larger the electron binding energy. Although vibronic coupling is ignored in most theoretical treatments of PADs in the direct photodetachment of molecular anions, the present findings clearly show that it can be important. These results represent a benchmark data set for a relatively simple system, upon which to base rigorous tests of more sophisticated models.

  7. Effectiveness of professional oral health care intervention on the oral health of residents with dementia in residential aged care facilities: a systematic review protocol. (United States)

    Yi Mohammadi, Joanna Jin; Franks, Kay; Hines, Sonia


    aged care facilities, with the model of care involving dental hygienists/oral health therapists having merit.The concept of professional oral care involves an oral health professional such as a dental hygienist or oral health therapist supervising or assisting residents with their oral care. Oral care involves the mechanical removal of plaque and food debris using a toothbrush, interproximal brush and floss.In 2014, Morino et al. explored the efficacy of short term professional oral care from dental hygienists once a week after breakfast for one month. In this study, the dental hygienists did not perform dental scaling but brushed subjects' teeth using a toothbrush and interdental brush. Dental plaque scores decreased significantly (Fisher's two-tailed tests, pconducted by Amerine et al. and utilized the dental hygienist as the "oral health champion" in the residential aged care facility using the Oral Health Assessment Tool (OHAT) and Geriatric Oral Health Assessment Index (GOHAI) scores to measure oral health. The results from this study showed improvements in three measured areas (tongue health, denture status and oral cleanliness) in the dental hygiene champion group. These findings suggest that the presence of a dental hygiene champion in long term care facilities may positively impact the oral health of residents requiring assistance with their oral care. However, the authors noted further research in this concept is required.Van Der Putten GJ et al. explored the effectiveness of a supervised implementation of an oral health care guideline in care homes. In each ward of the care homes, a nurse who acted as the ward oral health care organiser (WOO) was appointed. The dental hygienist and an investigator would attend the RACFs every six weeks to support them. The dental hygienist would train the WOO, and the WOO would train the ward nurses and nurse assistants. Participants were allocated into an intervention or a control group. The intervention group received

  8. Clinical implications of blood eosinophil count in patients with non-asthma–COPD overlap syndrome COPD

    Directory of Open Access Journals (Sweden)

    Song JH


    Full Text Available Jin Hwa Song,1 Chang-Hoon Lee,1 Jin Woo Kim,2 Won-Yeon Lee,3 Ji Ye Jung,4 Joo Hun Park,5 Ki Suck Jung,6 Kwang Ha Yoo,7 Yong Bum Park,8 Deog Keom Kim9 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, 2Division of Pulmonology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, 3Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do, 4Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, 5Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine, Suwon, 6Division of Pulmonary Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University Medical School, Anyang, Gyeonggi-do, 7Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, 8Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Kangdong Sacred Heart Hospital, 9Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea Background: Recent studies that assessed the relevance of the blood eosinophil count as a biomarker in patients with COPD may have overestimated it because they included patients with asthma–COPD overlap syndrome (ACOS. We investigated the clinical implications of the blood eosinophil count in patients with non-ACOS COPD.Patients and methods: From a Korean COPD Subtype Study (KOCOSS cohort, we selected patients with non-ACOS COPD after excluding ACOS patients according to Spanish criteria. Clinical characteristics and the incidence of moderate-to-severe exacerbation were compared

  9. Global distribution and Gas-particle Partitioning of Polycyclic Aromatic Hydrocarbons - a Modelling Study (United States)

    Lammel, G.; Sehili, A. M.


    organic matter and adsorption to black carbon (soot) to determine gas-particle partitioning. PAHs are multi-hopping to some extent and volatilization from ground exceeds deposition over dry parts of the continents and some sea regions at least seasonally. Bond T.C., Streets D.G., Yarber K.F., Nelson S.M., Woo J.H., Klimont Z. (2004), J. Geophys. Res. 109, D14203, doi:10.1029/2003JD003697 Lohmann R., Lammel G. (2004), Environ. Sci. Technol. 38, 3793-3803 Pankow J.F. (1987), Atmos. Environ. 21, 2275-2283 Sehili A.M., Lammel G. (2007), Atmos. Environ. 41, 8301-8315. Semeena V.S., Feichter J., Lammel G. (2006), Atmos. Chem. Phys. 6, 1231-1248 Stier P., Feichter J., Kinne S., Kloster S., Vignati E., Wilson J., Ganzeveld L., Tegen I., Werner M., Schulz M., Balkanski Y., Boucher O., Minikin A., Petzold A. (2005), Atmos. Chem. Phys. 5, 1125-1156

  10. Investigation and analysis of oncologists' knowledge of morphine usage in cancer pain treatment

    Directory of Open Access Journals (Sweden)

    Liu W


    Full Text Available Weiran Liu,1,* Shumin Xie,2,* Lin Yue,3,* Jiahao Liu,2 Stephanie Mu-Lian Woo,4 Weilin Liu,2 Adam R Miller,5 Jing Zhang,6 Lijun Huang,7 Lei Zhang8,*1Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Anesthesia, Tianjin, People's Republic of China; 2The Xiangya Medical School of Central-South University, Changsha, People's Republic of China; 3Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Outpatient Service, Tianjin, People's Republic of China; 4Harvard University, Cambridge, MA, USA; 5Indiana University School of Medicine, Indianapolis, IN, USA; 6Tianjin Medical University, Tianjin, People's Republic of China; 7Hunan Provincial Tumor Hospital, Department of Lymphoma and Hematology, Changsha, People's Republic of China; 8Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Lung Cancer Center, Department of Thoracic Surgery, Tianjin, People's Republic of China *These authors contributed equally to this paperPurpose: To examine oncologists' knowledge of cancer pain and morphine's clinical application in the People's Republic of China. In addition, this study analyzes and discusses the negative factors that currently affect the clinical application of morphine.Patients and methods: A questionnaire survey was given to a random sample of 150 oncologists from Tianjin Medical University Cancer Institute and Hospital. The statistical results were analyzed and processed using SPSS version 21.0 and Matlab version 2012a statistical software. Single-factor analysis of variance, Kruskal–Wallis nonparametric test, and independent samples t-test were adopted to analyze the difference in knowledge scores of morphine usage. The study

  11. Heart rate variability biofeedback in patients with alcohol dependence: a randomized controlled study

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    Penzlin AI


    Full Text Available Ana Isabel Penzlin,1 Timo Siepmann,2 Ben Min-Woo Illigens,3 Kerstin Weidner,4 Martin Siepmann4 1Institute of Clinical Pharmacology, 2Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Saxony, Germany; 3Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; 4Department of Psychotherapy and Psychosomatic Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Saxony, Germany Background and objective: In patients with alcohol dependence, ethyl-toxic damage of vasomotor and cardiac autonomic nerve fibers leads to autonomic imbalance with neurovascular and cardiac dysfunction, the latter resulting in reduced heart rate variability (HRV. Autonomic imbalance is linked to increased craving and cardiovascular mortality. In this study, we sought to assess the effects of HRV biofeedback training on HRV, vasomotor function, craving, and anxiety. Methods: We conducted a randomized controlled study in 48 patients (14 females, ages 25–59 years undergoing inpatient rehabilitation treatment. In the treatment group, patients (n=24 attended six sessions of HRV biofeedback over 2 weeks in addition to standard rehabilitative care, whereas, in the control group, subjects received standard care only. Psychometric testing for craving (Obsessive Compulsive Drinking Scale, anxiety (Symptom Checklist-90-Revised, HRV assessment using coefficient of variation of R-R intervals (CVNN analysis, and vasomotor function assessment using laser Doppler flowmetry were performed at baseline, immediately after completion of treatment or control period, and 3 and 6 weeks afterward (follow-ups 1 and 2. Results: Psychometric testing showed decreased craving in the biofeedback group immediately postintervention (OCDS scores: 8.6±7.9 post-biofeedback versus 13.7±11.0 baseline [mean ± standard deviation], P<0.05, whereas craving was unchanged at

  12. Association of genetic variations with pharmacokinetics and lipid-lowering response to atorvastatin in healthy Korean subjects

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    Woo HI


    Full Text Available Hye In Woo,1 Suk Ran Kim,2 Wooseong Huh,3,4 Jae-Wook Ko,4 Soo-Youn Lee4,5 1Department of Laboratory Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea; 2Clinical Research and Development, Hanmi Pharm. Co., Ltd., Seoul, Korea; 3Department of Medicine, 4Department of Clinical Pharmacology and Therapeutics, 5Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Background: Statins are effective agents in the primary and secondary prevention of cardiovascular disease, but treatment response to statins varies among individuals. We analyzed multiple genetic polymorphisms and assessed pharmacokinetic and lipid-lowering responses after atorvastatin 80 mg treatment in healthy Korean individuals.Methods: Atorvastatin 80 mg was given to 50 healthy Korean male volunteers. Blood samples were collected to measure plasma atorvastatin and lipid concentrations up to 48 hours after atorvastatin administration. Subjects were genotyped for 1,936 drug metabolism and transporter genetic polymorphisms using the Affymetrix DMET plus array.Results: The pharmacokinetics and lipid-lowering effect of atorvastatin showed remarkable interindividual variation. Three polymorphisms in the SLCO1B1, SLCO1B3, and ABCC2 genes were associated with either the maximum concentration (Cmax of atorvastatin or changes in total cholesterol or low-density lipoprotein cholesterol (LDL-C. Minor homozygotes (76.5 ng/mL of SLCO1B1 c.-910G>A showed higher Cmax than heterozygotes (34.0 ng/mL and major homozygotes (33.5 ng/mL, false discovery rate P=0.040. Cmax and the area under the plasma concentration curve from hour 0 to infinity (AUC∞ were higher in carriers of the SLCO1B1*17 haplotype that included c.-910G>A than in noncarriers (46.1 vs 32.8 ng/mL for Cmax; 221.5 vs 154.2 ng/mL for AUC∞. SLCO1B3 c.334G>T homozygotes (63.0 ng/mL also showed higher Cmax than

  13. The effect of clove-based herbal mouthwash on radiation-induced oral mucositis in patients with head and neck cancer: a single-blind randomized preliminary study

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    Kong M


    Full Text Available Moonkyoo Kong,1 Deok-Sang Hwang,2 Seong Woo Yoon,3 Jinsung Kim4 1Department of Radiation Oncology, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, 2Department of Korean Medicine Obstetrics & Gynecology, Kyung Hee University Medical Center, 3Department of Korean Internal Medicine, Korean Medicine Cancer Center, Kyung Hee University Hospital at Gangdong, 4Department of Korean Internal Medicine, Kyung Hee University Medical Center, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea Purpose: This study was performed to evaluate the efficacy and safety of clove-based herbal mouthwash in ameliorating radiation-induced oral mucositis in patients with head and neck cancer. Methods: Fourteen patients were prospectively enrolled in this study and randomized to either an experimental group or a control group. The patients of the experimental group swished their mouths with a clove-based herbal mouthwash during radiotherapy (RT, while the patients of the control group swished with clear water. The primary end point of this study was incidence of radiation-induced oral mucositis. The secondary end points were time to onset of radiation-induced oral mucositis, duration of radiation-induced oral mucositis, incidence of supplemental nutrition through feeding tube, maximum pain score, body weight loss, incidence of RT interruption, and duration of RT interruption. Results: The use of clove-based herbal mouthwash shortened the duration of grade ≥2 mucositis (24.3 days vs 37.1 days, P=0.044 and reduced body weight loss during RT (3.1% vs 7.4%, P=0.023 compared with clear water. The use of clove-based herbal mouthwash also reduced the incidence of grade 3 mucositis (28.6% vs 57.1%, supplemental nutrition (0% vs 28.6%, and RT interruption (14.3% vs 28.6%, and reduced the duration of grade 3 mucositis (5.1 days vs 17.7 days and RT interruption (1 days vs 8.5 days. In addition, clove-based herbal mouthwash

  14. Assessing the impact of a new delivery method of insulin on glycemic control using a novel trial design

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    Thomas Strack


    Full Text Available Thomas Strack1, Luc Martinez2, Stefano Del Prato3, Larry Blonde4, Burkhard Göke5, Vincent Woo6, Ann Millward7, Ramon Gomis8, Bill Canovatchel1, David Lawrence1, Nick Freemantle9 on behalf of the EXPERIENCE Trial Team1Pfizer Inc., New York, NY, USA; 2Société Française de Médecine Générale, Issy les Moulineaux, France; 3University of Pisa, Pisa, Italy; 4Ochsner Medical Center, New Orleans, LO, USA; 5University of Munich, Munich, Germany; 6Health Sciences Centre, Winnipeg, Canada; 7Peninsula Medical School, Plymouth, UK; 8University of Barcelona, Barcelona, Spain; 9University of Birmingham, Birmingham, UKObjective: The purpose of the trial was to examine the impact of inhaled human insulin (INH on patient or physician willingness to adopt insulin after oral diabetes agent failure.Research design and methods: The EXPERIENCE trial was a one-year randomized controlled trial conducted at primary, secondary and tertiary care facilities in Europe and North America. The primary study endpoint was difference in glycated hemoglobin (A1c between randomized groups at 26 weeks, and results from that phase have been reported previously. The present report concerns results from the second 26-week extension phase. We also consider the applicability of the design. The trial recruited 727 patients with type 2 diabetes mellitus who, prior to randomization, were using two or more oral diabetes agents and whose A1c was ≥8.0%. Patients were randomized to two treatment settings: Group 1 (usual care with the option of INH or Group 2 (usual care only. Usual care included adjusting oral therapy (optimizing current regimen or adding/deleting agents and/or initiating subcutaneous (SC insulin.Results: At baseline, insulin was initiated by more (odds ratio [OR] 6.0;95% confidence interval [CI] 4.2 to 8.8; P < 0.0001 patients in Group 1 (86.2%; 76.7% INH plus 9.5% SC than in Group 2 (50.7%; SC insulin only. The largest reduction from baseline in A1c was in Group 1 (

  15. Severe COPD cases from Korea, Poland, and USA have substantial differences in respiratory symptoms and other respiratory illnesses

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    Kim WJ


    Full Text Available Woo Jin Kim,1 Jae-Joon Yim,2 Deog Kyeom Kim,3 Myung Goo Lee,4 Anne L Fuhlbrigge,5 Pawel Sliwinski,6 Iwona Hawrylkiewicz,6 Emily S Wan,7,8 Michael H Cho,7,8 Edwin K Silverman7,8 1Department of Internal Medicine and Environmental Health Center, Kangwon National University Hospital, Chuncheon, 2Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Seoul National University College of Medicine, Seoul, 3Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, 4Division of Pulmonary, Allergy and Critical Care Medicine, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea; 5Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO, USA; 62nd Department of Respiratory Medicine, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland; 7Channing Division of Network Medicine, 8Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston, MA, USA Purpose: Chronic obstructive pulmonary disease (COPD, characterized by irreversible airflow obstruction, is a major cause of morbidity and mortality worldwide. However, geographic differences in the clinical characteristics of severe COPD patients have not been widely studied. Methods: We recruited a total of 828 severe COPD cases from three continents. Subjects in Poland were enrolled by the Institute of Tuberculosis and Lung Diseases in Warsaw; subjects in Korea participated at several university hospitals in Korea; and subjects in USA were enrolled at two clinics affiliated with academic medical centers. All subjects were over the age of 30 with at least 10 pack-years of cigarette smoking history. Cases manifested severe to very severe airflow obstruction with post-bronchodilator forced expiratory volume in 1 second (FEV1 <50

  16. Characteristics of stable chronic obstructive pulmonary disease patients in the pulmonology clinics of seven Asian cities

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    Oh YM


    Full Text Available Yeon-Mok Oh,1 Arvind B Bhome,2 Watchara Boonsawat,3 Kirthi Dias Gunasekera,4 Dushantha Madegedara,5 Luisito Idolor,6 Camilo Roa,6 Woo Jin Kim,7 Han-Pin Kuo,8 Chun-Hua Wang,8 Le Thi Tuyet Lan,9 Li-Cher Loh,10 Choo-Khoon Ong,10 Alan Ng,11 Masaharu Nishimura,12 Hironi Makita,12 Edwin K Silverman,13 Jae Seung Lee,1 Ting Yang,14 Yingxiang Lin,14 Chen Wang,14 Sang-Do Lee1  1Department of Pulmonary and Critical Care Medicine and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; 2Department of Pulmonary and Critical Care, "Friends of the Breathless" Foundation, Pune, India; 3Department of Medicine, Khon Kaen University, Khon Kaen, Thailand; 4Central Chest Clinic, Colombo and National Hospital of Sri Lanka; 5Respiratory Disease Treatment Unit and Teaching Hospital Kandy, Sri Lanka; 6Section of Respiratory Services and Physical Therapy and Rehabilitation Lung Center of the Philippines, Quezon City, Philippines; 7Department of Internal Medicine, Kangwon National University, Kang Won, Korea; 8Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan; 9Respiratory Care Center, University Medical Center Ho Chi Minh City, Vietnam; 10Department of Medicine, Penang Medical College, Penang, Malaysia; 11Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore; 12Division of Respiratory Medicine, Department of Internal Medicine, Hokkaido University Hospital, Sapporo, Japan; 13Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; 14Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaAll authors made an equal contribution to this studyBackground and objectives: Chronic obstructive pulmonary disease (COPD is responsible for significant morbidity and mortality worldwide. We evaluated the characteristics of stable COPD patients in

  17. Identification of subtypes in subjects with mild-to-moderate airflow limitation and its clinical and socioeconomic implications

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    Lee JH


    Full Text Available Jin Hwa Lee,1 Chin Kook Rhee,2 Kyungjoo Kim,2 Jee-Ae Kim,3 Sang Hyun Kim,4 Kwang Ha Yoo,5 Woo Jin Kim,6 Yong Bum Park,7 Hye Yun Park,8 Ki-Suck Jung9 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, EwhaWomans University, 2Department of Internal Medicine, Seoul St Mary’s Hospital, The Catholic University of Korea, Seoul, 3Pharmaceutical Policy Evaluation Research Team, Research Institution, Health Insurance Review and Assessment Service, 4Big Data Division, Health Insurance Review and Assessment Service, Wonju, 5Department of Internal Medicine, Konkuk University College of Medicine, Seoul, 6Department of Internal Medicine and Environmental Health Center, Kangwon National University Hospital, Chuncheon, 7Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, 8Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 9Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, Anyang, South Korea Purpose: The purpose of this study was to identify subtypes in patients with mild-to-moderate airflow limitation and to appreciate their clinical and socioeconomic implications.Methods: Subjects who were aged ≥20 years and had forced expiratory volume in 1 second (FEV1 ≥60% predicted and FEV1/forced vital capacity <0.7 were selected from the fourth Korea National Health and Nutrition Examination Survey (KNHANES in 2007–2012. The data were merged to the National Health Insurance reimbursement database during the same period. k-Means clustering was performed to explore subtypes. For clustering analysis, six key input variables – age, body mass index (BMI, FEV1% predicted, the presence or absence of self-reported wheezing

  18. A proposal for an individualized pharmacogenetic-guided isoniazid dosage regimen for patients with tuberculosis

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    Jung JA


    Full Text Available Jin Ah Jung,1 Tae-Eun Kim,2 Hyun Lee,3 Byeong-Ho Jeong,3 Hye Yun Park,3 Kyeongman Jeon,3 O Jung Kwon,3 Jae-Wook Ko,4 Rihwa Choi,5 Hye-In Woo,6 Won-Jung Koh,3 Soo-Youn Lee4,5 1Department of Clinical Pharmacology, Inje University College of Medicine, Inje University Busan Paik Hospital, Busan, Korea; 2Department of Clinical Pharmacology, Konkuk University Medical Center, 3Division of Pulmonary and Critical Care Medicine, Department of Medicine, 4Department of Clinical Pharmacology and Therapeutics, 5Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; 6Department of Laboratory Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea Background/aim: Isoniazid (INH is an essential component of first-line anti-tuberculosis (TB treatment. However, treatment with INH is complicated by polymorphisms in the expression of the enzyme system primarily responsible for its elimination, N-acetyltransferase 2 (NAT2, and its associated hepatotoxicity. The objective of this study was to develop an individualized INH dosing regimen using a pharmacogenetic-driven model and to apply this regimen in a pilot study.Methods: A total of 206 patients with TB who received anti-TB treatment were included in this prospective study. The 2-hour post-dose concentrations of INH were obtained, and their NAT2 genotype was determined using polymerase chain reaction and sequencing. A multivariate regression analysis that included the variables of age, sex, body weight, and NAT2 genotype was performed to determine the best model for estimating the INH dose that achieves a concentration of 3.0–6.0 mg/L. This dosing algorithm was then used for newly enrolled 53 patients.Results: Serum concentrations of INH were significantly lower in the rapid-acetylators than in the slow-acetylators (2.55 mg/L vs 6.78 mg/L, median, P<0.001. A multivariate stepwise linear

  19. Prejudice as moral action in Christian ethical decision-making

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    Stephanus J. Myburgh


    botse ao a sepedi�anago tsela le ka fao maitshwaro a botse a Mokriste a hlathwago ka maikarabelo a gagwe ka gona ka kakaret�o, a dira gore Bibele e �omi�we ka maikarabelo mo go t�eweng ga diphetho ka maitshwro a botse. Dikakanyo t�a mosekaseki(kwe�i�o ya motheo t�eo di theilwego godimo ga maitshwaro a botse a maikarabelo di dumelela mosekaseki go itshwarelela ka there�o ye e akanywago ya temana, t�eo di t�wago go modiro wa tshekatsheko woo o hlohlelet�ago maitshwaro a maleba ka tsela ya maikemi�et�o le go hlotla e le tswalano magareng ga digwalo t�efetilego le mosekaseki wa ga bjale.--- End of translation ---

  20. Combining probabilistic hazard assessment with cost-benefit analysis to support decision making in a volcanic crisis from the Auckland Volcanic Field, New Zealand (United States)

    Sandri, Laura; Jolly, Gill; Lindsay, Jan; Howe, Tracy; Marzocchi, Warner


    One of the main challenges of modern volcanology is to provide the public with robust and useful information for decision-making in land-use planning and in emergency management. From the scientific point of view, this translates into reliable and quantitative long- and short-term volcanic hazard assessment and eruption forecasting. Because of the complexity in characterizing volcanic events, and of the natural variability of volcanic processes, a probabilistic approach is more suitable than deterministic modeling. In recent years, two probabilistic codes have been developed for quantitative short- and long-term eruption forecasting (BET_EF) and volcanic hazard assessment (BET_VH). Both of them are based on a Bayesian Event Tree, in which volcanic events are seen as a chain of logical steps of increasing detail. At each node of the tree, the probability is computed by taking into account different sources of information, such as geological and volcanological models, past occurrences, expert opinion and numerical modeling of volcanic phenomena. Since it is a Bayesian tool, the output probability is not a single number, but a probability distribution accounting for aleatory and epistemic uncertainty. In this study, we apply BET_VH in order to quantify the long-term volcanic hazard due to base surge invasion in the region around Auckland, New Zealand's most populous city. Here, small basaltic eruptions from monogenetic cones pose a considerable risk to the city in case of phreatomagmatic activity: evidence for base surges are not uncommon in deposits from past events. Currently, we are particularly focussing on the scenario simulated during Exercise Ruaumoko, a national disaster exercise based on the build-up to an eruption in the Auckland Volcanic Field. Based on recent papers by Marzocchi and Woo, we suggest a possible quantitative strategy to link probabilistic scientific output and Boolean decision making. It is based on cost-benefit analysis, in which all costs

  1. Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells

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    Kim YW


    Full Text Available Yong-Wan Kim,1 Eun Young Kim,1 Doin Jeon,1 Juinn-Lin Liu,2 Helena Suhyun Kim,3 Jin Woo Choi,4 Woong Shick Ahn5 1Cancer Research Institute of Medical Science, The Catholic University of Korea, Seoul, Republic of Korea; 2Brain Tumor Center, Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, TX, USA; 3Cancer Rehab Laboratory, RH Healthcare Systems Inc, TX, USA; 4Harvard Medical School and Wellman Center for Photomedicine, Cambridge, MA, USA; 5Department of Obstetrics and Gynecology, The Catholic University of Korea, Seoul, Republic of Korea Abstract: Paclitaxel (Taxol resistance remains a major obstacle for the successful treatment of ovarian cancer. MicroRNAs (miRNAs have oncogenic and tumor suppressor activity and are associated with poor prognosis phenotypes. miRNA screenings for this drug resistance are needed to estimate the prognosis of the disease and find better drug targets. miRNAs that were differentially expressed in Taxol-resistant ovarian cancer cells, compared with Taxol-sensitive cells, were screened by Illumina Human MicroRNA Expression BeadChips. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR was used to identify target genes of selected miRNAs. Kaplan–Meier survival analysis was applied to identify dysregulated miRNAs in ovarian cancer patients using data from The Cancer Genome Atlas. A total of 82 miRNAs were identified in ovarian carcinoma cells compared to normal ovarian cells. miR-141, miR-106a, miR-200c, miR-96, and miR-378 were overexpressed, and miR-411, miR-432, miR-494, miR-409-3p, and miR-655 were underexpressed in ovarian cancer cells. Seventeen miRNAs were overexpressed in Taxol-resistant cells, including miR-663, miR-622, and HS_188. Underexpressed miRNAs in Taxol-sensitive cells included miR-497, miR-187, miR-195, and miR-107. We further showed miR-663 and miR-622 as significant prognosis markers of the chemo-resistant patient group. In particular, the

  2. Korean Medication Algorithm Project for Bipolar Disorder: third revision

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    Woo YS


    Full Text Available Young Sup Woo,1 Jung Goo Lee,2,3 Jong-Hyun Jeong,1 Moon-Doo Kim,4 Inki Sohn,5 Se-Hoon Shim,6 Duk-In Jon,7 Jeong Seok Seo,8 Young-Chul Shin,9 Kyung Joon Min,10 Bo-Hyun Yoon,11 Won-Myong Bahk1 1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, South Korea; 2Department of Psychiatry, Inje University Haeundae Paik Hospital, Busan, South Korea;3Paik Institute for Clinical Research, Inje Univeristy, Busan, South Korea; 4Department of Psychiatry, Jeju National University Hospital, Jeju, South Korea; 5Department of Psychiatry, Keyo Hospital, Keyo Medical Foundation, Uiwang, South Korea; 6Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Soonchunhyang University, Cheonan, South Korea; 7Department of Psychiatry, Sacred Heart Hospital, Hallym University, Anyang, South Korea; 8Department of Psychiatry, School of Medicine, Konkuk University, Chungju, South Korea; 9Department of Psychiatry, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, South Korea; 10Department of Psychiatry, College of Medicine, Chung-Ang University, Seoul, South Korea; 11Department of Psychiatry, Naju National Hospital, Naju, South Korea Objective: To constitute the third revision of the guidelines for the treatment of bipolar disorder issued by the Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP 2014. Methods: A 56-item questionnaire was used to obtain the consensus of experts regarding pharmacological treatment strategies for the various phases of bipolar disorder and for special populations. The review committee included 110 Korean psychiatrists and 38 experts for child and adolescent psychiatry. Of the committee members, 64 general psychiatrists and 23 child and adolescent psychiatrists responded to the survey. Results: The treatment of choice (TOC for euphoric, mixed, and psychotic mania was the combination of a mood stabilizer (MS and an atypical antipsychotic (AAP; the TOC for

  3. Biological test methods for the ecotoxicological characterization of wastes. Final report; Biologische Testerverfahren zur oekotoxikologischen Charakterisierung von Abfaellen. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Becker, Roland [Bundesanstalt fuer Materialforschung, Berlin (Germany); Donnevert, Gerhild [Fachhochschule Giessen-Friedberg (Germany). FB MNI; Roembke, Joerg [ECT Oekotoxikologie GmbH, Floersheim am Main (Germany)


    battery the acceptance rate varied between 74.1% (Algae test) and 92.6% (Daphnia test). Methodologically, no problems occurred but further guidance on moisture determination in the terrestrial tests as well as details concerning reference testing and data evaluation for several tests are needed. Independently which test system is considered, SOI always caused the lowest effects and WOO was most toxic, while the EC50 values of INC show an intermediate toxicity. Among the aquatic tests, daphnids and one algal species were the most sensitive ones, while plants were always more sensitive than earthworms in the solid waste samples. Based on the test results from additional tests proposals for the modification of the existing basic test battery could be made. For example, the earthworm acute test could be replaced by another soil invertebrate test with higher sensitivity. Further work performed in parallel to the ring test improves waste testing considerably (e.g. the use of artificial soil as control substrate). A comparison of the ring test results with literature data published so far revealed a good agreement. The results of this ring test support confirm that a combination of a battery of biological tests and chemical residue analysis is needed for an ecotoxicological characterization of wastes. With small modifications proposed in this report the basic test battery is considered to be well suitable for the hazard and risk assessment of wastes. Further, probably multi-variate evaluation of the ring test results will improve the identification of those tests most qualified for the ecotoxicological characterization of wastes. Finally, the experiences made in the ring test support also the proposals made in CEN guideline 14735 (2005) concerning the performance of such tests. (orig.)

  4. INTRODUCTION: Anticipated changes in the global atmospheric water cycle (United States)

    Allan, Richard P.; Liepert, Beate G.


    an important example. Understanding surface solar 'dimming' and 'brightening' trends in the context of past and current changes in the water cycle are discussed in a guest editorial by Wild and Liepert (2010). The key roles anthropogenic aerosols can play on a regional scale are discussed by Lau et al (2010) through their study of the regional impact of absorbing aerosols on warming and snow melt over the Himalayas. The overarching goal of climate prediction is to provide reliable, probabilistic estimates of future changes. Relating hydrological responses back to a sound physical basis, the motivation for this special focus issue, is paramount in building confidence in anticipated changes, especially in the global water cycle. We are grateful to the reviewers and the journal editorial board for making this focus issue possible. Focus on Anticipated Changes in the Global Atmospheric Water Cycle Contents Editorials The global atmospheric water cycle Lennart Bengtsson The Earth radiation balance as driver of the global hydrological cycle Martin Wild and Beate Liepert Letters Enhanced surface warming and accelerated snow melt in the Himalayas and Tibetan Plateau induced by absorbing aerosols William K M Lau, Maeng-Ki Kim, Kyu-Myong Kim and Woo-Seop Lee Current changes in tropical precipitation Richard P Allan, Brian J Soden, Viju O John, William Ingram and Peter Good Direct versus indirect effects of tropospheric humidity changes on the hydrologic cycle S C Sherwood How closely do changes in surface and column water vapor follow Clausius-Clapeyron scaling in climate change simulations? P A O'Gorman and C J Muller Linking increases in hourly precipitation extremes to atmospheric temperature and moisture changes Geert Lenderink and Erik van Meijgaard Are climate-related changes to the character of global-mean precipitation predictable? Graeme L Stephens and Yongxiang Hu A comparison of large scale changes in surface humidity over land in observations and CMIP3 general

  5. Comparison of hydration and nutritional status between young and elderly hemodialysis patients through bioimpedance analysis

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    Lee JE


    Full Text Available Jung Eun Lee,1,2 In Young Jo,3 Song Mi Lee,3 Woo Jeong Kim,3 Hoon Young Choi,2,4 Sung Kyu Ha,4 Hyung Jong Kim,5 Hyeong Cheon Park2,4 1Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, 2Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, 3Department of Nutrition Services, Gangnam Severance Hospital, 4Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, 5Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea Background: The number of elderly people on dialysis is increasing rapidly. Fluid overload and malnutrition status are serious problems in elderly dialysis patients. We aimed to compare the hydration and nutritional status through bioimpedance analysis (BIA between young and elderly hemodialysis (HD patients and to analyze risk factors related to fluid overload and malnutrition status in these patients.Method: We conducted a cross-sectional study, in which 82 HD (males 42, mean age 58.7±12.9 years patients were enrolled. We collected different types of data: laboratory data, such as serum creatinine, albumin, total iron-binding capacity, hemoglobin, total cholesterol; anthropometric data, such as hand grip strength (HGS; BIA data, such as intracellular water, skeletal muscle mass, body cell mass, bone mineral content, phase angle (PhA, extra cellular water (ECW/total body water (TBW ratio; and malnutrition-inflammation score (MIS, which is a traditional nutritional parameter for dialysis patients. All patients were stratified into two groups according to their age: young (<65 years [n=54] and elderly (≥65 years [n=28].Results: Total iron-binding capacity and HGS were significantly lower in elderly HD patients than in young HD patients (198.9±35.6 vs 221.4±52.1 mcg/dL; and 22.4±10.3 vs 36.4±23.2 kg, respectively (P<0.05. Also, intracellular water and Ph

  6. EDITORIAL: Invited papers from ISAMMA 2010 (Sendai, Japan, 12-16 July 2010) Invited papers from ISAMMA 2010 (Sendai, Japan, 12-16 July 2010) (United States)

    Takahashi, M.; Saito, H.


    overseas. The programme involved 4 plenary talks, 37 invited talks, 85 contributed talks and 352 posters. All submitted papers were reviewed in order to meet the standards of Journal of Physics D: Applied Physics and Journal of Physics: Conference Series. We are grateful to all participants for their valuable contributions and active discussions. We gratefully acknowledge the financial support of 17 Japanese companies and 7 Japanese foundations. Invited papers from ISAMMA 2010 Contents Current status and recent topics of rare-earth permanent magnets S Sugimoto Alloying effect on the magnetic properties of RFeB-type bulk magnets H W Chang, C C Hsieh, J Y Gan, Y T Cheng, M F Shih and W C Chang Coercivity distributions in Nd-Fe-B sintered magnets produced by the grain boundary diffusion process H Nakamura, K Hirota, T Ohashi and T Minowa Recent progress in high Bs Fe-based nanocrystalline soft magnetic alloys M Ohta and Y Yoshizawa Electric-field effects on magnetic anisotropy in Pd/Fe/Pd(0 0 1) surface Shinya Haraguchi, Masahito Tsujikawa, Junpei Gotou and Tatsuki Oda Gate modulation of spin precession in a semiconductor channel Hyun Cheol Koo, Jae Hyun Kwon, Jonghwa Eom, Joonyeon Chang, Suk Hee Han and Mark Johnson Ferromagnetic resonance of epitaxial Fe nanodots grown on MgO measured using coplanar waveguides M Mizuguchi and K Takanashi Switching phase diagrams of current-induced magnetization switching in asymmetric MgO-based magnetic tunnel junctions Seung-Young Park, Jae-Ho Han, Se-Chung Oh, Jang-Eun Lee, Kyung-Tae Nam, Hyun-Woo Lee, Younghun Jo and Kyung-Jin Lee Temperature dependence of spin-dependent transport properties of Co2MnSi-based current-perpendicular-to-plane magnetoresistive devices Y Sakuraba, K Izumi, S Bosu, K Saito and K Takanashi Adsorbate-induced spin-polarization enhancement of Fe3O4(0 0 1) A Pratt, M Kurahashi, X Sun and Y Yamauchi Antiferromagnetic coupling between spinel ferrite and α-Fe layers in Fe3-δO4/MgO/Fe(0 0 1) epitaxial films Hideto

  7. Different impacts of respiratory symptoms and comorbidities on COPD-specific health-related quality of life by COPD severity

    Directory of Open Access Journals (Sweden)

    Lee H


    Full Text Available Hyun Lee,1,* Byung Woo Jhun,1,* Juhee Cho,2–4 Kwang Ha Yoo,5 Jin Hwa Lee,6 Deog Kyeom Kim,7 Jong Deog Lee,8 Ki-Suck Jung,9 Jung Yeon Lee,10 Hye Yun Park1 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; 2Center for Clinical Epidemiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; 3Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; 4Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, South Korea; 5Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, South Korea; 6Division of Pulmonary and Critical Care Medicine, School of Medicine, Ewha Womans University, Seoul, South Korea; 7Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, South Korea; 8Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, South Korea; 9Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, Anyang, South Korea; 10Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungju Hospital, Konkuk University School of Medicine, Chungju, South Korea *These authors contributed equally to this work Background: Patients with chronic obstructive pulmonary disease (COPD often have poor health-related quality of life (HRQoL that is disproportionate to their degree of airflow limitation. This study evaluated the association between St

  8. INTRODUCTION Introduction to the conference proceeding of the Workshop on Electromagnetic Inverse ProblemsThe University of Manchester, UK, 15-18 June, 2009 (United States)

    Dorn, Oliver; Lionheart, Bill


    This proceeding combines selected contributions from participants of the Workshop on Electromagnetic Inverse Problems which was hosted by the University of Manchester in June 2009. The workshop was organized by the two guest editors of this conference proceeding and ran in parallel to the 10th International Conference on Electrical Impedance Tomography, which was guided by Bill Lionheart, Richard Bayford, and Eung Je Woo. Both events shared plenary talks and several selected sessions. One reason for combining these two events was the goal of bringing together scientists from various related disciplines who normally might not attend the same conferences, and to enhance discussions between these different groups. So, for example, one day of the workshop was dedicated to the broader area of geophysical inverse problems (including inverse problems in petroleum engineering), where participants from the EIT community and from the medical imaging community were also encouraged to participate, with great success. Other sessions concentrated on microwave medical imaging, on inverse scattering, or on eddy current imaging, with active feedback also from geophysically oriented scientists. Furthermore, several talks addressed such diverse topics as optical tomography, photoacoustic tomography, time reversal, or electrosensing fish. As a result of the workshop, speakers were invited to contribute extended papers to this conference proceeding. All submissions were thoroughly reviewed and, after a thoughtful revision by the authors, combined in this proceeding. The resulting set of six papers presenting the work of in total 22 authors from 5 different countries provides a very interesting overview of several of the themes which were represented at the workshop. These can be divided into two important categories, namely (i) modelling and (ii) data inversion. The first three papers of this selection, as outlined below, focus more on modelling aspects, being an essential component of

  9. Efficacy of fimasartan/hydrochlorothiazide combination in hypertensive patients inadequately controlled by fimasartan monotherapy

    Directory of Open Access Journals (Sweden)

    Rhee MY


    Full Text Available Moo-Yong Rhee,1 Sang Hong Baek,2 Weon Kim,3 Chang Gyu Park,4 Seung Woo Park,5 Byung-Hee Oh,6 Sang-Hyun Kim,7 Jae-Joong Kim,8 Joon-Han Shin,9 Byung-Su Yoo,10 Se-Joong Rim,11 Jong-Won Ha,12 Joon Hyung Doh,13 Youngkeun Ahn,14 Jei Keon Chae,15 Jeong Bae Park,16 Soon-Kil Kim,17 Cheol Ho Kim18 1Cardiovascular Center, Dongguk University Ilsan Hospital, Goyang, 2Catholic University of Korea, Seoul St Mary’s Hospital, Seoul, 3Cardiovascular Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, 4Division of Cardiology, Guro Hospital, Korea University College of Medicine, Seoul, 5Division of Cardiology, Samsung Medical Center, Seoul, 6Department of Internal Medicine, Seoul National University Hospital, Seoul, 7Division of Cardiology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, 8Division of Cardiology, Asan Medical Center, Seoul, 9Division of Cardiology, Ajou University Hospital, Suwon, 10Division of Cardiology, Wonju Severance Christian Hospital, Wonju, 11Division of Cardiology, GangNam Severance Hospital, Seoul, 12Division of Cardiology, Severance Hospital, Seoul, 13Division of Cardiology, Inje University Ilsan Hospital, Goyang, 14Department of Cardiology, Chonnam National University Hospital, Gwangju, 15Chonbuk National University Hospital, Jeonju, 16Department of Cardiology, Cheil General Hospital, Dankook University College of Medicine, Seoul, 17Department of Cardiology, Hanyang University Guri Hospital, Guri, 18Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea Background: The study reported here compared the blood pressure (BP-lowering efficacy of fimasartan alone with that of fimasartan/hydrochlorothiazide (HCTZ combination in patients whose BP goal was not achieved after 4 weeks of treatment with once-daily fimasartan 60 mg.Methods: Patients with sitting diastolic blood pressure (siDBP ≥90 mmHg with 4 weeks of once

  10. Principles of water oxidation and O2-based hydrocarbon transformation by multinuclear catalytic sites

    Energy Technology Data Exchange (ETDEWEB)

    Musaev, Djamaladdin G [Chemistry, Emory University; Hill, Craig L [Chemistry, Emory University; Morokuma, Keiji [Chemistry, Emory University


    centers in the active site form another part of considerable interest of our grant because species with such sites [including methane monooxygenase (MMO) and more] are some of the most effective oxygenase catalysts known. Our team conducted the following research on γ-M2-Keggin complexes: (a) investigated stability of the trimer [{Fe3(OH)3(H2O)2}3(γ-SiW10O36)3]15-, 4, in water, and developed the chemistry and catalysis of the di-iron centered POM, [γ(1,2)-SiW10{Fe(OH)}2O38]6-, 5, in organic solvents (Figure 2). We also study the thermodynamic and structural stability of γ-M2-Keggin in aqueous media for different M’s (d-electron metals). We have defined two structural classes of POMs with proximally bound d-electron metal centers. We refer to these structural isomers of the {γ-M2SiW10} family of POMs as “in-pocket” and “out-of pocket”. We have elucidated the factors controlling the structure and stability of the V, Fe, Ru, Tc, Mo and Rh derivatives of [(SiO4)M2(OH)2W10O32]4- using a range of computational tools. We have: (a) demonstrated that heteroatom X in these polyanions may function as an “internal switch” for defining the ground electronic states and, consequently, the reactivity of the γ-M2-Keggin POM complexes; (b) elucidated reactivity of divacant lacunary species and polyperoxotungstates (PPTs), {Xn+O4[WO(O2)2]4}n-, which could be degradation products of γ-M2-Keggin complexes in aqueous media; (c) elucidated the role of the POM ligand in stabilization of {Ru2} and {(Ru-oxo)2} fragments in the reactant and product of the reaction of {γ-[(Xn+O4)Ru2(OH)2W10O32]}(8-n)- (where X = Si4+, P5+ and S6+) with O2, and (d) the mechanisms of olefin epoxidation catalyzed by these di-d-transition metal substituted and divacant lacunary γ-M2-Keggin complexes. III. Complementing the efforts presented above was the development of less time-consuming but reasonably accurate computational methods allowing one to explore more deeply large catalytic systems. We

  11. Nanotechnology in paper electronics (United States)

    Demming, Anna; Österbacka, Professor Ronald; Han, Jin-Woo, Dr


    The ability to put cutting edge technology on paper—not in words but in a working physical form—has been attracting an increasing number of researchers over the past decade. Paper has many advantages that make it attractive for flexible electronics: it is relatively environmentally benign; it is renewable; it can be recycled; it is light weight; production processes for paper are well advanced; and it is inexpensive. This special issue, with guest editors Ronald Österbacka from Åbo Akademi University in Finland and Jin-Woo Han from the NASA AMES Research Center, features some of the latest in paper electronics research, including developments towards applications in displays, sensing and alternative energy sources, as well as fundamental studies to further our understanding of how paper can be most effectively used in electronics. As Andrew Steckl and colleagues in the US point out, 'Cellulose-based paper substrates were implemented as an electronic substrate as early as 1969, with most advancement occurring in the past decade largely due to technology improvements in thin film deposition and organic materials' [1, 2]. They report a detailed comparison between paper, standard liquid crystal display rigid glass and flexible glass for hosting pentacene organic thin film transistors, and obtain promising results for future paper-based devices. As most meaningful electronic devices rely on transistors to function, transistors feature quite prominently in this special issue. Rodrigo Martins and colleagues in France and Portugal study the effect of fibre type, structure and dimension on paper-based transistors and reveal further insights into how paper properties affect device performance [3]. Qing Wan and colleagues in China bring the state of the art in transistor technology to paper substrates [4], fabricating indium-zinc-oxide (IZO)-based protonic/electronic hybrid thin film transistors on paper and showing that they can be used as artificial synapses. Like the

  12. Alledaagse omgang tussen zorgprofessionals en zorgontvangers als vindplaats voor goede (LVB zorg

    Directory of Open Access Journals (Sweden)

    Michael Kolen


    influences in observation reports (Kolen, Timmerman & Vosman, 2015, 2016. Between September 2011 and December 2012, we followed 19 young people with a mild intellectual disability (IQ 50 – 85 in their day-to-day contact with care professionals in the context of three different care organizations. Each of these young people was followed for the duration of one day. The observation reports were open-coded using tools such as the “underwater screen”. This gave us an initial impression of what is at stake for young people and for care givers in their day-to-day contact, and which institutional influences on everyday contact can be identified. We then developed a coding system. This was the first step towards understanding the dynamic that is present in day-to-day contact. In doing this, we viewed the actions of care givers, residents, and the institutional context in a praxeological manner, as doing, leaving, and undergoing (Nicolini, 2012; Schmidt, 2012; Schatzki, 2002; Schäfer, 2016; Vosman et al., 2016. The results of the coding system were processed in an extended data matrix (Miles, Huberman & Saldaña, 2013 in which the day-to-day contact between the three actors was described on the basis of scenes (Woo, Rennie & Poyntz, 2015 from the empirical material. We subsequently developed a “densified matrix” in order to identify characteristics that would make it possible to compare the scenes with each other. This resulted in three main characteristics: the actions of the resident, the actions of the care giver, and the actions of the institutional context. These three characteristics of scenes are the three dimensions of the “characteristics space” (Lazarsfeld, 1937, in which we searched for a moral orientation that manifests itself in everyday contact. We did this by analysing a series of scenes, leading us to the concept of “attending to” (Kolen, Vosman & Timmerman, 2016b. This concept is based on Hannah Arendt’s concept of power. She sees power as a

  13. Antimicrobial Susceptibility Pattern of Pseudomonas aeruginosa Isolated from Patients Referring to Hospitals

    Directory of Open Access Journals (Sweden)

    Zeynab Golshani


    New beta-Lactams, Alone and in Combination with beta-Lactamase Inhibitors, Against Clinical Isolates Resistant to Third Generation Cephalosporins. Braz J Infect Dis 2006;10(1:22-5. 4. Lister PD, Wolter DJ, Hanson ND. Antibacterial-Resistant Pseudomonas aeruginosa : Clinical Impact and Complex Regulation of Chromosomally Encoded Resistance Mechanisms. Clin Microbiol Rev 2009;22(4:582–610. 5. Shahid M, Malik A. Plasmid mediated amikacin resistance in clinical isolates of Pseudomonas aeruginosa . Indian J Med Microbiol 2004;22(3:182-4. 6. Song W, Woo HJ, Kim JS, Lee KM. In vitro activity of beta-lactams in combination with other antimicrobial agents against resistant strains of Pseudomonas aeruginosa . Int J Antimicrobiol Agents 2003;21(1:8-12. 7. Brown PD, Izundu A. Antibiotic resistance in clinical isolates of Pseudomonas aeruginosa in Jamaica. Rev Panam Salud Publica/Pan Am J Public Health 2004;16(2:125-30. 8. Dundar D, Otkun M. In-Vitro Efficacy of Synergistic Antibiotic Combinations in Multidrug Resistant Pseudomonas Aeruginosa Strains. Yonsei Med J 2010;51(1:111-6. 9. Tam VH, Chang KT, Abdelraouf K, Brioso CG, Ameka M, McCaskey LA, et al. Prevalence, Resistance Mechanisms, and Susceptibility of Multidrug-Resistant Bloodstream Isolates of Pseudomonas aeruginosa . Antimicrob Agents Chemother 2010;54(3:1160-4. 10. Mirsalehian A, Feizabadi M, Nakhjavani FA, Jabalameli F, Goli H, Kalantari N. Detection of VEB-1, OXA-10 and PER-1genotypes in extended-spectrum beta-lactamase- producing Pseudomonas aeruginosa strains isolated from burn patients. Burns.2010;36(1:70-4. 11. Patzer JA, Dzierzanowska D. Increase of imipenem resistance among Pseudomonas aeruginosa isolates from a Polish paediatric hospital (1993-2002. Int J Antimicrob Agents 2007;29(2:153-8. 12. Walkty A, Decorby M, Nichol K, Mulvey MR, Hoban D, Zhanel G; Canadian Antimicrobial Resistance Alliance. Antimicrobial susceptibility of Pseudomonas aeruginosa isolates obtained from patients in Canadian intensive care

  14. EDITORIAL: Focus on Heart and Mind (United States)

    Bodenschatz, Eberhard; Wolf, Fred


    tractable to support a comprehensive analysis of functional performance at the systems level. Analogously, experimental work increasingly probes the system dynamics simultaneously at multiple levels from cell to whole organ. Here an invaluable contribution of physics to the experimental characterization of large scale activity in cardiac and neuronal tissues is the currently emerging high level of quantitative precision and control. Long-term high precision recording of large scale activity patterns of neural and cardiac tissues increasingly supports the formulation of quantitative phenomenological theories of complex dynamical states as well the realization of algorithms for manipulating and controlling them. Both quantitative phenomenology and control are not only essential for bridging theory and experiment in complex systems; they are also indispensable for turning scientific insight into diagnostic progress and improved treatment for the affected heart and mind. The present Focus Issue in New Journal of Physics reflects well the richness and excitement of this currently rapidly evolving field. It combines theoretical and experimental approaches and covers analyses ranging from the organ level over investigations of model systems to the biophysics of individual cells. The articles below represent the first contributions to this collection and further additions will appear in the near future. Focus on Heart and Mind Contents 'Heart' contributions Spiral wave drift and complex-oscillatory spiral waves caused by heterogeneities in two-dimensional in vitro cardiac tissues Sung-Jae Woo, Jin Hee Hong, Tae Yun Kim, Byung Wook Bae and Kyoung J Lee Epicardial wavefronts arise from widely distributed transient sources during ventricular fibrillation in the isolated swine heart J M Rogers, G P Walcott, J D Gladden, S B Melnick, R E Ideker and M W Kay Efficient control of spiral wave location in an excitable medium with localized heterogeneities J Schlesner, V S Zykov, H Brandtst

  15. Impact of explosive eruption scenarios at Vesuvius (United States)

    Zuccaro, G.; Cacace, F.; Spence, R. J. S.; Baxter, P. J.


    In the paper the first attempt at the definition of a model to assess the impact of a range of different volcanic hazards on the building structures is presented. This theoretical approach has been achieved within the activities of the EXPLORIS Project supported by the EU. A time history for Sub-Plinian I eruptive scenario of the Vesuvius is assumed by taking advantage of interpretation of historical reports of volcanic crises of the past [Carafa, G. 1632. In opusculum de novissima Vesuvij conflagratione, epistola isagogica, 2 a ed. Napoli, Naples; Mascolo, G.B., 1634. De incendio Vesuvii excitato xvij. Kal. Ianuar. anno trigesimo primo sæculi Decimiseptimi libri X. Cum Chronologia superiorum incendiorum; & Ephemeride ultimi. Napoli; Varrone, S., 1634. Vesuviani incendii historiae libri tres. Napoli], numerical simulations [Neri, A., Esposti Ongaro, T., Macedonio, G., Gidaspow, D., 2003. Multiparticle simulation of collapsing volcanic columns and pyroclastic flows. J. Geophys. Res. Lett. 108, 2202. doi:10.1029/2001 JB000508; Macedonio, G., Costa, A., Longo, A., 2005. HAZMAP: a computer model for volcanic ash fallout and assessment of subsequent hazard. Comput. Geosci. 31,837-845; Costa, A., Macedonio, G., Folch, A., 2006. A three-dimensional Eulerian model for transport and deposition of volcanic ashes. Earth Planet. Sci. Lett. 241,634-647] and experts' elicitations [Aspinall, W.P., 2006. Structured elicitation of expert judgment for probabilistic hazard and risk assessment in volcanic eruptions. In: Mader, H.M. Coles, S.G. Connor, C.B. Connor, L.J. (Eds), Statistics in Volcanology. Geological Society of London on behalf of IAVCEI, pp.15-30; Woo, G., 1999. The Mathematics of Natural Catastrophes. Imperial College Press, London] from which the impact on the building structures is derived. This is achieved by an original definition of vulnerability functions for multi-hazard input and a dynamic cumulative damage model. Factors affecting the variability of the final

  16. EDITORIAL Complexity of advanced radiation therapy necessitates multidisciplinary inquiry into dose reconstruction and risk assessment Complexity of advanced radiation therapy necessitates multidisciplinary inquiry into dose reconstruction and risk assessment (United States)

    Newhauser, Wayne


    -614 Stovall M, Weathers R, Kasper C, Smith S A, Travis L, Ron E and Kleinerman R 2006 Dose reconstruction for therapeutic and diagnostic radiation exposures: use in epidemiological studies Radiat. Res. 166 141-57 Taddei P J, Chell E, Hansen S, Gertner M and Newhauser W D 2010a Assessment of targeting accuracy of a low-energy stereotactic radiosurgery treatment for age-related macular degeneration Phys. Med. Biol. 55 7037-54 Taddei P J, Howell R M, Krishnan S, Scarboro S B, Mirkovic D and Newhauser W D 2010b Risk of second malignant neoplasm following proton versus intensity-modulated photon radiotherapies for hepatocellular carcinoma Phys. Med. Biol. 55 7055-65 Taddei P J, Mahajan A, Mirkovic D, Zhang R, Giebeler A, Kornguth D, Harvey M, Woo S and Newhauser W D 2010c Predicted risks of second malignant neoplasm incidence and mortality due to secondary neutrons in a girl and boy receiving proton craniospinal irradiation Phys. Med. Biol. 55 7067-80 Titt U, Mirkovic D, Sawakuchi G O, Perles L A, Newhauser W D, Taddei P J and Mohan R 2010 Adjustment of the lateral and longitudinal size of scanned proton beam spots using a pre-absorber to optimize penumbrae and delivery efficiency Phys. Med. Biol. 55 7097-106 Travis L B 2006 The epidemiology of second primary cancers Cancer Epidemiol. Biomarkers Prev. 15 2020-6 Wolkenhauer O et al 2010 Systems biologists seek fuller integration of systems biology approaches in new cancer research programs Cancer Res. 70 12-3 Xu X G, Bednarz B and Paganetti H 2008 A review of dosimetry studies on external-beam radiation treatment with respect to second cancer induction Phys. Med. Biol. 53 R193-241 Yepes P, Mirkovic D and Taddei P J 2010 A GPU implementation of a track-repeating algorithm for proton radiotherapy dose calculations Phys. Med. Biol. 55 7107-20 Zhang R, P\\'{e}rez-And\\'{u}jar A, Fontenot J D, Taddei P J and Newhauser W D 2010 An analytic model of neutron ambient dose equivalent and equivalent dose for proton radiotherapy Phys. Med