Sample records for saturation-transfer difference std

  1. Ligand screening by saturation-transfer difference (STD) NMR spectroscopy.

    Energy Technology Data Exchange (ETDEWEB)

    Krishnan, V V


    NMR based methods to screen for high-affinity ligands have become an indispensable tool for designing rationalized drugs, as these offer a combination of good experimental design of the screening process and data interpretation methods, which together provide unprecedented information on the complex nature of protein-ligand interactions. These methods rely on measuring direct changes in the spectral parameters, that are often simpler than the complex experimental procedures used to study structure and dynamics of proteins. The goal of this review article is to provide the basic details of NMR based ligand-screening methods, with particular focus on the saturation transfer difference (STD) experiment. In addition, we provide an overview of other NMR experimental methods and a practical guide on how to go about designing and implementing them.

  2. Enhanced signal dispersion in saturation transfer difference experiments by conversion to a 1D-STD-homodecoupled spectrum

    Energy Technology Data Exchange (ETDEWEB)

    Martin-Pastor, Manuel; Vega-Vazquez, Marino [Universidade de Santiago de Compostela, Laboratorio Integral de Dinamica e Estructura de Biomoleculas Jose R. Carracido, Unidade de Resonancia Magnetica, Edificio CACTUS, RIAIDT (Spain); Capua, Antonia De [Seconda Universita degli Studi di Napoli, Dipartimento di Scienze Ambientali (Italy); Canales, Angeles [Centro de Investigaciones Biologicas, CSIC, Departamento de Estructura y funcion de proteinas (Spain); Andre, Sabine; Gabius, Hans-Joachim [Ludwig-Maximilians-Universitaet, Institut fuer Physiologische Chemie, Tieraerztliche Fakultaet (Germany); Jimenez-Barbero, Jesus [Centro de Investigaciones Biologicas, CSIC, Departamento de Estructura y funcion de proteinas (Spain)], E-mail:


    The saturation transfer difference (STD) experiment is a rich source of information on topological aspects of ligand binding to a receptor. The epitope mapping is based on a magnetization transfer after signal saturation from the receptor to the ligand, where interproton distances permit this process. Signal overlap in the STD spectrum can cause difficulties to correctly assign and/or quantitate the measured enhancements. To address this issue we report here a modified version of the routine experiment and a processing scheme that provides a 1D-STD homodecoupled spectrum (i.e. an experiment in which all STD signals appear as singlets) with line widths similar to those in original STD spectrum. These refinements contribute to alleviate problems of signal overlap. The experiment is based on 2D-J-resolved spectroscopy, one of the fastest 2D experiments under conventional data sampling in the indirect dimension, and provides excellent sensitivity, a key factor for the difference experiments.

  3. Interaction between Wine Phenolic Acids and Salivary Proteins by Saturation-Transfer Difference Nuclear Magnetic Resonance Spectroscopy (STD-NMR) and Molecular Dynamics Simulations. (United States)

    Ferrer-Gallego, Raúl; Hernández-Hierro, José Miguel; Brás, Natércia F; Vale, Nuno; Gomes, Paula; Mateus, Nuno; de Freitas, Victor; Heredia, Francisco J; Escribano-Bailón, María Teresa


    The interaction between phenolic compounds and salivary proteins is highly related to the astringency perception. Recently, it has been proven the existence of synergisms on the perceived astringency when phenolic acids were tested as mixtures in comparison to individual compounds, maintaining constant the total amount of the stimulus. The interactions between wine phenolic acids and the peptide fragment IB712 have been studied by saturation-transfer difference (STD) NMR spectroscopy. This technique provided the dissociation constants and the percentage of interaction between both individual and mixtures of hydroxybenzoic and hydroxycinnamic acids and the model peptide. It is noteworthy that hydroxybenzoic acids showed higher affinity for the peptide than hydroxycinnamic acids. To obtain further insights into the mechanisms of interaction, molecular dynamics simulations have been performed. Results obtained not only showed the ability of these compounds to interact with salivary proteins but also may justify the synergistic effect observed in previous sensory studies.

  4. Group epitope mapping considering relaxation of the ligand (GEM-CRL): Including longitudinal relaxation rates in the analysis of saturation transfer difference (STD) experiments (United States)

    Kemper, Sebastian; Patel, Mitul K.; Errey, James C.; Davis, Benjamin G.; Jones, Jonathan A.; Claridge, Timothy D. W.


    In the application of saturation transfer difference (STD) experiments to the study of protein-ligand interactions, the relaxation of the ligand is one of the major influences on the experimentally observed STD factors, making interpretation of these difficult when attempting to define a group epitope map (GEM). In this paper, we describe a simplification of the relaxation matrix that may be applied under specified experimental conditions, which results in a simplified equation reflecting the directly transferred magnetisation rate from the protein onto the ligand, defined as the summation over the whole protein of the protein-ligand cross-relaxation multiplied by with the fractional saturation of the protein protons. In this, the relaxation of the ligand is accounted for implicitly by inclusion of the experimentally determined longitudinal relaxation rates. The conditions under which this "group epitope mapping considering relaxation of the ligand" (GEM-CRL) can be applied were tested on a theoretical model system, which demonstrated only minor deviations from that predicted by the full relaxation matrix calculations (CORCEMA-ST) [7]. Furthermore, CORCEMA-ST calculations of two protein-saccharide complexes (Jacalin and TreR) with known crystal structures were performed and compared with experimental GEM-CRL data. It could be shown that the GEM-CRL methodology is superior to the classical group epitope mapping approach currently used for defining ligand-protein proximities. GEM-CRL is also useful for the interpretation of CORCEMA-ST results, because the transferred magnetisation rate provides an additional parameter for the comparison between measured and calculated values. The independence of this parameter from the above mentioned factors can thereby enhance the value of CORCEMA-ST calculations.

  5. Close-up of the alpha-1,3-Gal epitope as defined by a monoclonal chimeric IgE and human serum using saturation transfer difference (STD) NMR

    DEFF Research Database (Denmark)

    Plum, Melanie; Michel, Yvonne; Wallach, Katharina


    by mediator release assays, surface plasmon resonance (SPR) and STD NMR analyses. The alpha-Gal-specific chimeric IgE and IgG antibodies were proven functional regarding interaction with antigen and Fc receptors. SPR measurements demonstrated affinities in the micromolar range. In contrast to a reference...

  6. Saturation transfer difference NMR and computational modeling of a sialoadhesin-sialyl lactose complex. (United States)

    Bhunia, Anirban; Jayalakshmi, V; Benie, Andrew J; Schuster, Oliver; Kelm, Sørge; Rama Krishna, N; Peters, Thomas


    The siglecs are a family of I-type lectins binding to sialic acids on the cell surface. Sialoadhesin (siglec-1) is expressed at much higher levels in inflammatory macrophages and specifically binds to alpha-2,3-sialylated N-acetyl lactosamine residues of glycan chains. The terminal disaccharide alpha-D-Neu5Ac-(2-->3)-beta-D-Gal is thought to be the main epitope recognized by sialoadhesin. To understand the basis of this biological recognition reaction we combined NMR experiments with a molecular modeling study. We employed saturation transfer difference (STD) NMR experiments to characterize the binding epitope of alpha-2,3-sialylated lactose, alpha-D-Neu5Ac-(2-->3)-beta-D-Gal-(1-->4)-D-Glc 1 to sialoadhesin at atomic resolution. The experimental results were compared to a computational docking model and to X-ray data of a complex of sialyl lactose and sialoadhesin. The data reveal that sialoadhesin mainly recognizes the N-acetyl neuraminic acid and a small part of the galactose moiety of 1. The crystal structure of a complex of sialoadhesin with sialyl lactose 1 was used as a basis for a modeling study using the FlexiDock algorithm. The model generated was very similar to the original crystal structure. Therefore, the X-ray data were used to predict theoretical STD values utilizing the CORCEMA-STD protocol. The good agreement between experimental and theoretical STD values indicates that a combined modeling/STD NMR approach yields a reliable structural model for the complex of sialoadhesin with alpha-D-Neu5Ac-(2-->3)-beta-D-Gal-(1-->4)-D-Glc 1 in aqueous solution.

  7. Saturation transfer difference nuclear magnetic resonance titrations reveal complex multistep-binding of l-fucose to norovirus particles. (United States)

    Mallagaray, Alvaro; Rademacher, Christoph; Parra, Francisco; Hansman, Grant; Peters, Thomas


    Recently, combined nuclear magnetic resonance (NMR), native mass spectrometry (MS) and X-ray crystallographic studies have demonstrated that binding of histo-blood group antigens (HBGAs) to norovirus capsid protein (P-dimers) is a cooperative process involving four binding pockets. Here, we show that binding to norovirus virus-like particles (VLPs) is even more complex. We performed saturation transfer difference (STD) NMR titration experiments with two representative genotypes of norovirus VLPs using l-fucose as a minimal HBGA. Compared to titrations with P-dimers, the corresponding binding isotherms reflect at least six distinct binding events. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail:

  8. Binding events of (S )-N -(3-oxo-octanoyl)-homoserine lactone with agrobacterium tumefaciens mutant cells studied by saturation transfer difference NMR

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    Cabeca, Luis Fernando; Pomini, Armando Mateus; Cruz, Pedro Luiz R.; Marsaioli, Anita J. [University of Campinas (UNICAMP), SP (Brazil). Chemistry Inst.


    Quorum-sensing is a widely studied communication phenomenon in bacteria, which involves the production and detection of signaling substances in relation with cell density and colony behavior. Herein, the membrane binding interactions of the signal (S)-N-(3-oxo-octanoyl)-HSL with A. tumefaciens NTL4(pZLR4) cells were studied using saturation transfer difference NMR spectroscopy (STD-NMR). The substance epitope map was obtained showing that the hydrophobic acyl chain is the most important interacting site for the signal and the cell membrane. Results were interpreted upon comparisons with a simpler system, using liposomes as membrane models. Some insights on the use of b-cyclodextrin as acyl-HSL carrier were also provided. (author)

  9. Saturation Transfer Difference NMR as an Analytical Tool for Detection and Differentiation of Plastic Explosives on the Basis of Minor Plasticizer Composition (United States)


    HMX); ethylene glycol dinitrate (EGDN); ammonium nitrate (AN); and nitrocellulose (NC).1–4 Alternatively, in one recent study,5 plastic explosive mixtures. Top trace (red) represents the 1D 1H NMR for all plasticizers present together in the NMR sample (1.0 mM concentration ...saturation transfer difference AN ammonium nitrate BSA bovine serum albumin EGDN ethylene glycol dinitrate HDO partially deuterated water HMX

  10. An Introduction to Drug Discovery by Probing Protein-Substrate Interactions Using Saturation Transfer Difference-Nuclear Magnetic Resonance (STD-NMR) (United States)

    Guegan, Jean-Paul; Daniellou, Richard


    NMR spectroscopy is a powerful tool for characterizing and identifying molecules and nowadays is even used to characterize complex systems in biology. In the experiment presented here, students learned how to apply this modern technique to probe interactions between small molecules and proteins. With the use of simple organic synthesis, students…

  11. Cellular and Molecular Imaging Using Chemical Exchange Saturation Transfer. (United States)

    McMahon, Michael T; Gilad, Assaf A


    Chemical exchange saturation transfer (CEST) is a powerful new tool well suited for molecular imaging. This technology enables the detection of low concentration probes through selective labeling of rapidly exchanging protons or other spins on the probes. In this review, we will highlight the unique features of CEST imaging technology and describe the different types of CEST agents that are suited for molecular imaging studies, including CEST theranostic agents, CEST reporter genes, and CEST environmental sensors.

  12. Exploring Gender Differences in the Relationship between HIV/STD Testing and Condom Use among Undergraduate College Students (United States)

    Bontempi, Jean Breny; Mugno, Raymond; Bulmer, Sandra M.; Danvers, Karina; Vancour, Michele L.


    Background: Rates of HIV/AIDS, and other sexually transmitted diseases (STDs), are increasing among university students. Purpose: The purpose of this study was to examine gender differences in the relationship between condom use and (1) HIV/STD testing behaviors, (2) STD treatment behaviors and, (3) alcohol use behaviors. Methods: A survey was…

  13. {beta}-Lactam antibiotics epitope mapping with STD NMR spectroscopy: a study of drug-human serum albumin interaction

    Energy Technology Data Exchange (ETDEWEB)

    Milagre, Cintia D. F.; Cabeca, Luis F.; Almeida, Wanda P.; Marsaioli, Anita J., E-mail: [Institute of Chemistry, University of Campinas (UNICAMP), SP (Brazil)


    Molecular recognition events are key issues in many biological processes. STD NMR (saturation transfer difference nuclear magnetic resonance spectroscopy) is one of the techniques used to understand such biological interactions. Herein, we have investigated the interactions of four {beta}-lactam antibiotics belonging to two classes (cephalosporins and penicillins) with human serum albumin (HSA) by {sup 1}H STD NMR revealing that the interaction between the aromatic moiety and HSA is responsible for the binding efficiency. Thus, the structural differences from the five to six-membered thio ring in penicillins and cephalosporins do not seem to influence antibiotic albumin interactions. (author)

  14. A STD-NMR Study of the Interaction of the Anabaena Ferredoxin-NADP+ Reductase with the Coenzyme

    Directory of Open Access Journals (Sweden)

    Lara V. Antonini


    Full Text Available Ferredoxin-NADP+ reductase (FNR catalyzes the electron transfer from ferredoxin to NADP+ via its flavin FAD cofactor. To get further insights in the architecture of the transient complexes produced during the hydride transfer event between the enzyme and the NADP+ coenzyme we have applied NMR spectroscopy using Saturation Transfer Difference (STD techniques to analyze the interaction between FNRox and the oxidized state of its NADP+ coenzyme. We have found that STD NMR, together with the use of selected mutations on FNR and of the non-FNR reacting coenzyme analogue NAD+, are appropriate tools to provide further information about the the interaction epitope.

  15. Optimal sampling schedule for chemical exchange saturation transfer. (United States)

    Tee, Y K; Khrapitchev, A A; Sibson, N R; Payne, S J; Chappell, M A


    The sampling schedule for chemical exchange saturation transfer imaging is normally uniformly distributed across the saturation frequency offsets. When this kind of evenly distributed sampling schedule is used to quantify the chemical exchange saturation transfer effect using model-based analysis, some of the collected data are minimally informative to the parameters of interest. For example, changes in labile proton exchange rate and concentration mainly affect the magnetization near the resonance frequency of the labile pool. In this study, an optimal sampling schedule was designed for a more accurate quantification of amine proton exchange rate and concentration, and water center frequency shift based on an algorithm previously applied to magnetization transfer and arterial spin labeling. The resulting optimal sampling schedule samples repeatedly around the resonance frequency of the amine pool and also near to the water resonance to maximize the information present within the data for quantitative model-based analysis. Simulation and experimental results on tissue-like phantoms showed that greater accuracy and precision (>30% and >46%, respectively, for some cases) were achieved in the parameters of interest when using optimal sampling schedule compared with evenly distributed sampling schedule. Hence, the proposed optimal sampling schedule could replace evenly distributed sampling schedule in chemical exchange saturation transfer imaging to improve the quantification of the chemical exchange saturation transfer effect and parameter estimation. Copyright © 2013 Wiley Periodicals, Inc.

  16. Exposure to Different Types of Violence and Subsequent Sexual Risk Behavior among Female STD Clinic Patients: A Latent Class Analysis (United States)

    Walsh, Jennifer L.; Senn, Theresa E.; Carey, Michael P.


    Objective Diverse forms of violence, including childhood maltreatment (CM), intimate partner violence (IPV), and exposure to community violence (ECV), have been linked separately with sexual risk behaviors. However, few studies have explored multiple experiences of violence simultaneously in relation to sexual risk-taking, especially in women who are most vulnerable to violent experiences. Methods Participants were 481 women (66% African American, Mage = 27 years) attending a publicly-funded STD clinic who reported on their past and current experiences with violence and their current sexual risk behavior. We identified patterns of experience with violence using latent class analysis (LCA) and investigated which combinations of experiences were associated with the riskiest sexual outcomes. Results Four classes of women with different experiences of violence were identified: Low Violence (39%), Predominantly ECV (20%), Predominantly CM (23%), and Multiply Victimized (18%). Women in the Multiply Victimized and Predominantly ECV classes reported the highest levels of sexual risk behavior, including more lifetime sexual partners and a greater likelihood of receiving STD treatment and using substances before sex. Conclusions Women with different patterns of violent experiences differed in their sexual risk behavior. Interventions to reduce sexual risk should address violence against women, focusing on experiences with multiple types of violence and experiences specifically with ECV. Additional research is needed to determine the best ways to address violence in sexual risk reduction interventions. PMID:23626921

  17. Target-specific NMR detection of protein–ligand interactions with antibody-relayed {sup 15}N-group selective STD

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    Hetényi, Anasztázia [University of Szeged, Department of Medical Chemistry (Hungary); Hegedűs, Zsófia [University of Szeged, SZTE-MTA Lendület Foldamer Research Group, Institute of Pharmaceutical Analysis Department (Hungary); Fajka-Boja, Roberta; Monostori, Éva [Biological Research Center of the Hungarian Academy of Sciences, Lymphocyte Signal Transduction Laboratory, Institute of Genetics (Hungary); Kövér, Katalin E. [University of Debrecen, Department of Inorganic and Analytical Chemistry (Hungary); Martinek, Tamás A., E-mail: [University of Szeged, SZTE-MTA Lendület Foldamer Research Group, Institute of Pharmaceutical Analysis Department (Hungary)


    Fragment-based drug design has been successfully applied to challenging targets where the detection of the weak protein–ligand interactions is a key element. {sup 1}H saturation transfer difference (STD) NMR spectroscopy is a powerful technique for this work but it requires pure homogeneous proteins as targets. Monoclonal antibody (mAb)-relayed {sup 15}N-GS STD spectroscopy has been developed to resolve the problem of protein mixtures and impure proteins. A {sup 15}N-labelled target-specific mAb is selectively irradiated and the saturation is relayed through the target to the ligand. Tests on the anti-Gal-1 mAb/Gal-1/lactose system showed that the approach is experimentally feasible in a reasonable time frame. This method allows detection and identification of binding molecules directly from a protein mixture in a multicomponent system.

  18. Chemical exchange saturation transfer MR imaging of Parkinson's disease at 3 Tesla

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    Li, Chunmei; Peng, Shuai; Wang, Rui; Chen, Min [Beijing Hospital, Department of Radiology, Beijing (China); Chen, Haibo; Su, Wen [Beijing Hospital, Department of Neurology, Beijing (China); Zhao, Xuna [Peking University, Center for MRI Research and Beijing City Key Lab for Medical Physics and Engineering, Beijing (China); Zhou, Jinyuan [Johns Hopkins University, Department of Radiology, Baltimore, MD (United States)


    To demonstrate the feasibility of using chemical exchange saturation transfer (CEST) imaging to detect Parkinson's disease (PD) in patients at 3 Tesla. Twenty-seven PD patients (17 men and 10 women; age range, 54-77 years) and 22 age-matched normal controls (13 men and 9 women; age range, 55-73 years) were examined on a 3-Tesla MRI system. Magnetization transfer spectra with 31 different frequency offsets (-6 to 6 ppm) were acquired at two transverse slices of the head, including the basal ganglia and midbrain. One-way analysis of variance tests was used to compare the differences in CEST imaging signals between PD patients and normal controls. Total CEST signal between the offsets of 0 and 4 ppm in the substantia nigra was significantly lower in PD patients than in normal controls (P = 0.006), which could be associated with the loss of dopaminergic neurons. Protein-based CEST imaging signals at the offset of 3.5 ppm in the globus pallidus, putamen and caudate were significantly increased in PD patients, compared to normal controls (P < 0.001, P = 0.003, P < 0.001, respectively). CEST imaging signals could potentially serve as imaging biomarkers to aid in the non-invasive molecular diagnosis of PD. (orig.)

  19. A 1H STD NMR spectroscopic investigation of sialylnucleoside mimetics as probes of CMP-Kdn synthetase. (United States)

    Haselhorst, Thomas; Oschlies, Melanie; Abu-Izneid, Tareq; Kiefel, Milton J; Tiralongo, Joe; Münster-Kühnel, Anja K; Gerardy-Schahn, Rita; von Itzstein, Mark


    CMP-Kdn synthetase catalyses the reaction of sialic acids (Sia) and CTP to the corresponding activated sugar nucleotide CMP-Sia and pyrophosphate PP( i ). Saturation Transfer Difference (STD) NMR spectroscopy has been employed to investigate the sub-structural requirements of the enzyme's binding domain. Sialylnucleoside mimetics, where the sialic acid moiety has been replaced by a carboxyl group and a hydrophobic moiety, have been used in NMR experiments, to probe the tolerance of the CMP-Kdn synthetase to such replacements. From our data it would appear that unlike another sialylnucleotide-recognising protein, the CMP-Neu5Ac transport protein, either a phosphate group or other functional groups on the sialic acid framework may play important roles in recognition by the synthetase.

  20. Application of chemical exchange saturation transfer (CEST) MRI for endogenous contrast at 7 Tesla. (United States)

    Dula, Adrienne N; Smith, Seth A; Gore, John C


    Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) indirectly images exchangeable solute protons resonating at frequencies different than bulk water. These solute protons are selectively saturated using low bandwidth RF irradiation and saturation is transferred to bulk water protons via chemical exchange, resulting in an attenuation of the measured water proton signal. CEST MRI is an advanced MRI technique with wide application potential due to the ability to examine complex molecular contributions. CEST MRI at high field (7 Tesla [7 T]) will improve the overall results due to increase in signal, T1 relaxation time, and chemical shift dispersion. Increased field strength translates to enhanced quantification of the metabolite of interest, allowing more fundamental studies on underlying pathophysiology. CEST contrast is affected by several tissue properties, such as the concentrations of exchange partners and their rate of proton exchange, whose effects have been examined and explored in this review. We have highlighted the background of CEST MRI, typical implementation strategy, and complications at 7 T. Copyright © 2013 by the American Society of Neuroimaging.

  1. WAter Saturation Shift Referencing (WASSR) for chemical exchange saturation transfer experiments (United States)

    Kim, Mina; Gillen, Joseph; Landman, Bennett. A.; Zhou, Jinyuan; van Zijl, Peter C.M.


    Chemical exchange saturation transfer (CEST) is a contrast mechanism exploiting exchange-based magnetization transfer (MT) between solute and water protons. CEST effects compete with direct water saturation and conventional MT processes and generally can only be quantified through an asymmetry analysis of the water saturation spectrum (Z-spectrum) with respect to the water frequency, a process that is exquisitely sensitive to magnetic field inhomogeneities. Here, it is shown that direct water saturation imaging allows measurement of the absolute water frequency in each voxel, allowing proper centering of Z-spectra on a voxel-by-voxel basis independent of spatial B0 field variations. Optimal acquisition parameters for this “water saturation shift referencing” or “WASSR” approach were estimated using Monte Carlo simulations and later confirmed experimentally. The optimal ratio of the WASSR sweep width to the linewidth of the direct saturation curve was found to be 3.3–4.0, requiring a sampling of 16–32 points. The frequency error was smaller than 1 Hz at signal to noise ratios of 40 or higher. The WASSR method was applied to study glycogen, where the chemical shift difference between the hydroxyl (OH) protons and bulk water protons at 3T is so small (0.75–1.25 ppm) that the CEST spectrum is inconclusive without proper referencing. PMID:19358232

  2. Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments. (United States)

    Kim, Mina; Gillen, Joseph; Landman, Bennett A; Zhou, Jinyuan; van Zijl, Peter C M


    Chemical exchange saturation transfer (CEST) is a contrast mechanism that exploits exchange-based magnetization transfer (MT) between solute and water protons. CEST effects compete with direct water saturation and conventional MT processes, and generally can only be quantified through an asymmetry analysis of the water saturation spectrum (Z-spectrum) with respect to the water frequency, a process that is exquisitely sensitive to magnetic field inhomogeneities. Here it is shown that direct water saturation imaging allows measurement of the absolute water frequency in each voxel, allowing proper centering of Z-spectra on a voxel-by-voxel basis independently of spatial B(0) field variations. Optimal acquisition parameters for this "water saturation shift referencing" (WASSR) approach were estimated using Monte Carlo simulations and later confirmed experimentally. The optimal ratio of the WASSR sweep width to the linewidth of the direct saturation curve was found to be 3.3-4.0, requiring a sampling of 16-32 points. The frequency error was smaller than 1 Hz at signal-to-noise ratios of 40 or higher. The WASSR method was applied to study glycogen, where the chemical shift difference between the hydroxyl (OH) protons and bulk water protons at 3T is so small (0.75-1.25 ppm) that the CEST spectrum is inconclusive without proper referencing.

  3. Correcting reaction rates measured by saturation-transfer magnetic resonance spectroscopy (United States)

    Gabr, Refaat E.; Weiss, Robert G.; Bottomley, Paul A.


    Off-resonance or spillover irradiation and incomplete saturation can introduce significant errors in the estimates of chemical rate constants measured by saturation-transfer magnetic resonance spectroscopy (MRS). Existing methods of correction are effective only over a limited parameter range. Here, a general approach of numerically solving the Bloch-McConnell equations to calculate exchange rates, relaxation times and concentrations for the saturation-transfer experiment is investigated, but found to require more measurements and higher signal-to-noise ratios than in vivo studies can practically afford. As an alternative, correction formulae for the reaction rate are provided which account for the expected parameter ranges and limited measurements available in vivo. The correction term is a quadratic function of experimental measurements. In computer simulations, the new formulae showed negligible bias and reduced the maximum error in the rate constants by about 3-fold compared to traditional formulae, and the error scatter by about 4-fold, over a wide range of parameters for conventional saturation transfer employing progressive saturation, and for the four-angle saturation-transfer method applied to the creatine kinase (CK) reaction in the human heart at 1.5 T. In normal in vivo spectra affected by spillover, the correction increases the mean calculated forward CK reaction rate by 6-16% over traditional and prior correction formulae.

  4. Std trends in chengalpattu hospital

    Directory of Open Access Journals (Sweden)

    Krishnamurthy V


    Full Text Available A retrospective data analysis was carried out to find the trends in frequency and distribution of different STDs at Chengalpattu during 1988-1994. Of the 4549 patients who attended the clinic 3621 (79.6% were males and 928 (20.4% were females. The commonest STD was Chancroid (24.4% in men and Syphillis (29% in women. Balanoposthitis (11.4% ranked third among STDs in males. Though the STD attendance showed a declining trend, most diseases showed a constant distribution. The percentage composition of secondary and latent syphillis, Genital Warts, Genital Herpes and the Non-Venereal group showed an increased composition in recent years. Primary syphillis in females showed a definite declining trend. The HIV sero-positive detection rate was 2.06%. Of the 1116 patients screened for HIV antibody, 23 patients were detected sero-positive. Time Series Regression Analysis was used to predict the number of patients who would attend the STD clinic with various STDs in 1995 and 1996 to help in the understanding of the disease load and pattern in future, in resources management and in developing and evaluating preventive measures.

  5. Glycosaminoglycan chemical exchange saturation transfer of lumbar intervertebral discs in patients with spondyloarthritis. (United States)

    Schleich, Christoph; Müller-Lutz, Anja; Matuschke, Felix; Sewerin, Philipp; Sengewein, Ruben; Schmitt, Benjamin; Ostendorf, Benedikt; Wittsack, Hans-Jörg; Stanke, Karolin; Antoch, Gerald; Miese, Falk


    To assess glycosaminoglycan (GAG) content of lumbar intervertebral discs (IVD) in patients with spondyloarthritis (SpA) using glycosaminoglycan chemical exchange saturation transfer (gagCEST). Ninety lumbar intervertebral discs of nine patients with SpA and nine age-matched healthy controls (eight patients with ankylosing spondylitis; one patient with spondylitis related to inflammatory bowel disease; mean age: 44.1 ± 14.0 years; range: 27-72 years) were examined with a 3T magnetic resonance imaging (MRI) scanner in this prospective study. The MRI protocol included standard morphological, sagittal T2 -weighted (T2 w) images to assess Pfirrmann score of the five lumbar IVDs (L1 to S1) and biochemical imaging with gagCEST to calculate a region of interest analysis of nucleus pulposus (NP) and annulus fibrosus (AF). Prior to statistical testing of gagCEST effects (MTRasym values in percent) in patients and controls, IVDs were classified according to the Pfirrmann score. Significantly lower gagCEST values of NP and AF were found in SpA patients compared with healthy volunteers (NP: 1.41% ± 0.41%, P = 0.001; 95% confidence interval, CI [0.600%-2.226%]; AF: 1.19% ± 0.32%, P < 0.001; CI [0.560%-1.822%]) by comparing the differences of the means. Pooled nondegenerative IVDs (Pfirrmann 1 and 2) had significantly lower gagCEST effects in patients suffering from SpA compared with healthy controls in NP (P < 0.001; CI [1.176%-2.337%]) and AF (P < 0.001; CI [0.858%-1.779%]). No significant difference of MTRasym values was found in degenerative IVDs between patients and controls in NP (P = 0.204; CI [-0.504%-2.170%]). GagCEST analysis of morphologically nondegenerative IVDs (Pfirrmann score 1 and 2) in T2 w images demonstrated significantly lower GAG values in patients with spondyloarthritis in NP and AF, possibly representing a depletion of GAG in spondyloarthritis in the absence of morphologic degeneration. © 2015 Wiley Periodicals, Inc.

  6. Design and optimization of pulsed Chemical Exchange Saturation Transfer MRI using a multiobjective genetic algorithm. (United States)

    Yoshimaru, Eriko S; Randtke, Edward A; Pagel, Mark D; Cárdenas-Rodríguez, Julio


    Pulsed Chemical Exchange Saturation Transfer (CEST) MRI experimental parameters and RF saturation pulse shapes were optimized using a multiobjective genetic algorithm. The optimization was carried out for RF saturation duty cycles of 50% and 90%, and results were compared to continuous wave saturation and Gaussian waveform. In both simulation and phantom experiments, continuous wave saturation performed the best, followed by parameters and shapes optimized by the genetic algorithm and then followed by Gaussian waveform. We have successfully demonstrated that the genetic algorithm is able to optimize pulse CEST parameters and that the results are translatable to clinical scanners. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. Improvement of water saturation shift referencing by sequence and analysis optimization to enhance chemical exchange saturation transfer imaging. (United States)

    Müller-Lutz, Anja; Matuschke, Felix; Schleich, Christoph; Wickrath, Frithjof; Boos, Johannes; Schmitt, Benjamin; Wittsack, Hans-Jörg


    To optimize B0-field inhomogeneity correction for chemical exchange saturation transfer (CEST) imaging by investigating different water saturation shift referencing (WASSR) Z-spectrum shapes and different frequency correction techniques. WASSR Z-spectra were simulated for different B1-fields and pulse durations (PD). Two parameter settings were used for further simulations and experiments (WASSR1: B1=0.1 μT, PD=50ms; WASSR2: B1=0.3 μT, PD=40ms). Four frequency correction techniques were investigated: 1) MinW: Minimum of the spline-interpolated WASSR-spectrum; 2) MSCF: maximum symmetry center frequency algorithm; 3) PMSCF: further development of MSCF algorithm; 4) BFit: fit with Bloch equations. Performance of frequency correction was assessed with Monte-Carlo simulations and in-vivo MR examinations in the brain and intervertebral disks. Different shapes of WASSR-Z-spectra were obtained by changing B1 and PD including spectra with one (1-Peak) or two (2-Peak) minima. WASSR1 resulted in 1-Peak WASSR-spectrum, whereas WASSR2 resulted in 2-Peak WASSR-spectrum. Both Monte-Carlo simulations and in-vivo MR examinations revealed highest accuracy of field-inhomogeneity correction with WASSR1 combined with PMSCF or BFit. Using a WASSR sequence, which results in a Z-spectrum with a single absorption peak, in combination with advanced postprocessing algorithms enables improved B0-field inhomogeneity correction for CEST imaging. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. Glycosaminoglycan chemical exchange saturation transfer in human lumbar intervertebral discs: Effect of saturation pulse and relationship with low back pain. (United States)

    Wada, Tatsuhiro; Togao, Osamu; Tokunaga, Chiaki; Funatsu, Ryohei; Yamashita, Yasuo; Kobayashi, Kouji; Nakamura, Yasuhiko; Honda, Hiroshi


    To evaluate the dependence of saturation pulse power and duration on glycosaminoglycan chemical exchange saturation transfer (gagCEST) imaging and assess the degeneration of human lumbar intervertebral discs (IVDs) using this method. All images were acquired on a 3T magnetic resonance imaging (MRI) scanner. The CEST effects were measured in the glycosaminoglycan (GAG) phantoms with different concentrations. In the human study, CEST effects were measured in the nucleus pulposus of IVD. We compared the CEST effects among the different saturation pulse powers (0.4, 0.8, and 1.6 μT) or durations (0.5, 1.0, and 2.0 sec) at each Pfirrmann grade (I-V). The relationship between the CEST effects and low back pain was also evaluated. The phantom study showed high correlations between the CEST effects and GAG concentration (R 2  = 0.863, P low back pain were significantly lower than those in the groups without pain (P pain (P = 0.0216). The contrast of gagCEST imaging in the lumbar IVDs varied with saturation pulse power and duration. GagCEST imaging may serve as a tool for evaluating IVD degeneration in the lumbar spine. 2 J. Magn. Reson. Imaging 2017;45:863-871. © 2016 International Society for Magnetic Resonance in Medicine.

  9. Transfer Rate Edited experiment for the selective detection of Chemical Exchange via Saturation Transfer (TRE-CEST). (United States)

    Friedman, Joshua I; Xia, Ding; Regatte, Ravinder R; Jerschow, Alexej


    Chemical Exchange Saturation Transfer (CEST) magnetic resonance experiments have become valuable tools in magnetic resonance for the detection of low concentration solutes with far greater sensitivity than direct detection methods. Accurate measures of rates of chemical exchange provided by CEST are of particular interest to biomedical imaging communities where variations in chemical exchange can be related to subtle variations in biomarker concentration, temperature and pH within tissues using MRI. Despite their name, however, traditional CEST methods are not truly selective for chemical exchange and instead detect all forms of magnetization transfer including through-space NOE. This ambiguity crowds CEST spectra and greatly complicates subsequent data analysis. We have developed a Transfer Rate Edited CEST experiment (TRE-CEST) that uses two different types of solute labeling in order to selectively amplify signals of rapidly exchanging proton species while simultaneously suppressing 'slower' NOE-dominated magnetization transfer processes. This approach is demonstrated in the context of both NMR and MRI, where it is used to detect the labile amide protons of proteins undergoing chemical exchange (at rates⩾30s(-1)) while simultaneously eliminating signals originating from slower (∼5s(-1)) NOE-mediated magnetization transfer processes. TRE-CEST greatly expands the utility of CEST experiments in complex systems, and in-vivo, in particular, where it is expected to improve the quantification of chemical exchange and magnetization transfer rates while enabling new forms of imaging contrast. Copyright © 2015 Elsevier Inc. All rights reserved.

  10. STD Awareness Month PSA (:30)

    Centers for Disease Control (CDC) Podcasts


    April is National STD Awareness Month. STDs can affect anyone. Many STDs don't have symptoms so it's important to get tested.  Created: 4/19/2011 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention.   Date Released: 4/19/2011.

  11. Nuclear overhauser enhancement mediated chemical exchange saturation transfer imaging at 7 Tesla in glioblastoma patients.

    Directory of Open Access Journals (Sweden)

    Daniel Paech

    Full Text Available BACKGROUND AND PURPOSE: Nuclear Overhauser Enhancement (NOE mediated chemical exchange saturation transfer (CEST is a novel magnetic resonance imaging (MRI technique on the basis of saturation transfer between exchanging protons of tissue proteins and bulk water. The purpose of this study was to evaluate and compare the information provided by three dimensional NOE mediated CEST at 7 Tesla (7T and standard MRI in glioblastoma patients. PATIENTS AND METHODS: Twelve patients with newly diagnosed histologically proven glioblastoma were enrolled in this prospective ethics committee-approved study. NOE mediated CEST contrast was acquired with a modified three-dimensional gradient-echo sequence and asymmetry analysis was conducted at 3.3 ppm (B1 = 0.7 µT to calculate the magnetization transfer ratio asymmetry (MTR(asym. Contrast enhanced T1 (CE-T1 and T2-weighted images were acquired at 3T and used for data co-registration and comparison. RESULTS: Mean NOE mediated CEST signal based on MTR(asym values over all patients was significantly increased (p<0.001 in CE-T1 tumor (-1.99 ± 1.22%, tumor necrosis (-1.36 ± 1.30% and peritumoral CEST hyperintensities (PTCH within T2 edema margins (-3.56 ± 1.24% compared to contralateral normal appearing white matter (-8.38 ± 1.19%. In CE-T1 tumor (p = 0.015 and tumor necrosis (p<0.001 mean MTR(asym values were significantly higher than in PTCH. Extent of the surrounding tumor hyperintensity was smaller in eight out of 12 patients on CEST than on T2-weighted images, while four displayed at equal size. In all patients, isolated high intensity regions (0.40 ± 2.21% displayed on CEST within the CE-T1 tumor that were not discernible on CE-T1 or T2-weighted images. CONCLUSION: NOE mediated CEST Imaging at 7 T provides additional information on the structure of peritumoral hyperintensities in glioblastoma and displays isolated high intensity regions within the CE-T1 tumor that cannot be acquired on CE-T1 or T2

  12. Europium(III) Macrocyclic Complexes with Alcohol Pendant Groups as Chemical Exchange Saturation Transfer Agents (United States)

    Woods, Mark; Woessner, Donald E.; Zhao, Piyu; Pasha, Azhar; Yang, Meng-Yin; Huang, Ching-Hui; Vasalitiy, Olga; Morrow, Janet R.; Sherry, A. Dean


    Paramagnetic lanthanide(III) complexes that contain hyperfine-shifted exchangeable protons offer considerable advantages over diamagnetic molecules as chemical exchange saturation transfer (CEST) agents for MRI. As part of a program to investigate avenues to improve the sensitivity of such agents, the CEST characteristics of europium(III) macrocyclic complexes having appended hydroxyethyl groups were investigated. The CEST spectrum of the asymmetrical complex, EuCNPHC3+, shows five distinct peaks for each magnetically nonequivalent exchangeable proton in the molecule. The CEST spectra of this complex were fitted to NMR Bloch theory to yield exchange rates between each of six exchanging proton pools (five on the agent plus bulk water). Exchange between the Eu3+-bound hydroxyl protons and bulk water protons was slow in dry acetonitrile but accelerated incrementally upon stepwise addition of water. In pure water, exchange was too fast to observe a CEST effect. The utility of this class of europium(III) complex for CEST imaging applications is ultimately limited by the small chemical shifts induced by the hydroxyl-appended ligands of this type and the resulting small Δω values for the exchangeable hydroxyl protons. PMID:16881645

  13. A Potential Magnetic Resonance Imaging Technique Based on Chemical Exchange Saturation Transfer for In Vivo γ-Aminobutyric Acid Imaging.

    Directory of Open Access Journals (Sweden)

    Gen Yan

    Full Text Available We developed a novel magnetic resonance imaging (MRI technique based on chemical exchange saturation transfer (CEST for GABA imaging and investigated the concentration-dependent CEST effect ofGABA in a rat model of brain tumor with blood-brain barrier (BBB disruption.All MRI studies were performed using a 7.0-T Agilent MRI scanner. Z-spectra for GABA were acquired at 7.0 T, 37°C, and a pH of 7.0 using varying B1 amplitudes. CEST images of phantoms with different concentrations of GABA solutions (pH, 7.0 and other metabolites (glutamine, myoinositol, creatinine, and choline were collected to investigate the concentration-dependent CEST effect of GABA and the potential contribution from other brain metabolites. CEST maps for GABA in rat brains with tumors were collected at baseline and 50 min, 1.5 h, and 2.0 h after the injection of GABA solution.The CEST effect of GABA was observed at approximately 2.75 parts per million(ppm downfield from bulk water, and this effect increased with an increase in the B1 amplitude and remained steady after the B1 amplitude reached 6.0 μT (255 Hz. The CEST effect of GABA was proportional to the GABA concentration in vitro. CEST imaging of GABA in a rat brain with a tumor and compromised BBB showed a gradual increase in the CEST effect after GABA injection.The findings of this study demonstrate the feasibility and potential of CEST MRI with the optimal B1 amplitude, which exhibits excellent spatial and temporal resolutions, to map changes in GABA.

  14. Biochemical imaging of cervical intervertebral discs with glycosaminoglycan chemical exchange saturation transfer magnetic resonance imaging: feasibility and initial results

    Energy Technology Data Exchange (ETDEWEB)

    Schleich, Christoph; Mueller-Lutz, Anja; Zimmermann, Lisa; Boos, Johannes; Wittsack, Hans-Joerg; Antoch, Gerald; Miese, Falk [Department of Diagnostic and Interventional Radiology, University Dusseldorf, Medical Faculty, Dusseldorf (Germany); Schmitt, Benjamin [Siemens Ltd. Australia, Healthcare Sector, Macquarie Park, NSW (Australia)


    To evaluate glycosaminoglycan chemical exchange saturation transfer (gagCEST) imaging at 3T in the assessment of the GAG content of cervical IVDs in healthy volunteers. Forty-two cervical intervertebral discs of seven healthy volunteers (four females, three males; mean age: 21.4 ± 1.4 years; range: 19-24 years) were examined at a 3T MRI scanner in this prospective study. The MRI protocol comprised standard morphological, sagittal T2 weighted (T2w) images to assess the magnetic resonance imaging (MRI) based grading system for cervical intervertebral disc degeneration (IVD) and biochemical imaging with gagCEST to calculate a region-of-interest analysis of nucleus pulposus (NP) and annulus fibrosus (AF). GagCEST of cervical IVDs was technically successful at 3T with significant higher gagCEST values in NP compared to AF (1.17 % ± 1.03 % vs. 0.79 % ± 1.75 %; p = 0.005). We found topological differences of gagCEST values of the cervical spine with significant higher gagCEST effects in lower IVDs (r = 1; p = 0). We could demonstrate a significant, negative correlation between gagCEST values and cervical disc degeneration of NP (r = -0.360; p = 0.019). Non-degenerated IVDs had significantly higher gagCEST effects compared to degenerated IVDs in NP (1.76 % ± 0.92 % vs. 0.52 % ± 1.17 %; p < 0.001). Biochemical imaging of cervical IVDs is feasible at 3T. GagCEST analysis demonstrated a topological GAG distribution of the cervical spine. The depletion of GAG in the NP with increasing level of morphological degeneration can be assessed using gagCEST imaging. (orig.)

  15. The effect of HIV, behavioural change, and STD syndromic management on STD epidemiology in sub-Saharan Africa: simulations of Uganda

    NARCIS (Netherlands)

    E.L. Korenromp (Eline); R. Bakker (Roel); R. Gray; M.J. Wawer; D. Serwadda; J.D.F. Habbema (Dik)


    textabstractAn assessment was made of how the HIV epidemic may have influenced sexually transmitted disease (STD) epidemiology in Uganda, and how HIV would affect the effectiveness of syndromic STD treatment programmes during different stages of the epidemic. The dynamic

  16. Science to Practice: Monitoring Oncolytic Virus Therapy with Chemical Exchange Saturation Transfer MR Imaging--Wishful Thinking? (United States)

    Choyke, Peter L


    Farrar et al demonstrate that modifying an oncolytic virus (OV) so that it produces excess protein when it infects a cancer cell is a process that can be detected both in vitro and in vivo in infected cancer cells by using chemical exchange saturation transfer (CEST) magnetic resonance (MR) imaging. The effect is at the limits of MR imaging detection (approximately 1%), but experience with functional MR imaging of the brain, with comparably small effects, should give pause to anyone who immediately writes this observation off as an exercise in wishful thinking. OVs are improving in their specificity, virulence, and ability to induce immune responses. Now, they have been modified to express proteins that are detectable with CEST MR imaging early after delivery into a tumor. This is clearly a surprising and hopeful development in the long road of OVs from the laboratory to the clinic.

  17. Dynamics of tropomyosin in muscle fibers as monitored by saturation transfer EPR of bi-functional probe.

    Directory of Open Access Journals (Sweden)

    Roni F Rayes

    Full Text Available The dynamics of four regions of tropomyosin was assessed using saturation transfer electron paramagnetic resonance in the muscle fiber. In order to fully immobilize the spin probe on the surface of tropomyosin, a bi-functional spin label was attached to i,i+4 positions via cysteine mutagenesis. The dynamics of bi-functionally labeled tropomyosin mutants decreased by three orders of magnitude when reconstituted into "ghost muscle fibers". The rates of motion varied along the length of tropomyosin with the C-terminus position 268/272 being one order of magnitude slower then N-terminal domain or the center of the molecule. Introduction of troponin decreases the dynamics of all four sites in the muscle fiber, but there was no significant effect upon addition of calcium or myosin subfragment-1.

  18. Imaging in Vivo Extracellular pH with a Single Paramagnetic Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Contrast Agent

    Directory of Open Access Journals (Sweden)

    Guanshu Liu


    Full Text Available The measurement of extracellular pH (pHe has potential utility for cancer diagnoses and for assessing the therapeutic effects of pH-dependent therapies. A single magnetic resonance imaging (MRI contrast agent that is detected through paramagnetic chemical exchange saturation transfer (PARACEST was designed to measure tumor pHe throughout the range of physiologic pH and with magnetic resonance saturation powers that are not harmful to a mouse model of cancer. The chemical characterization and modeling of the contrast agent Yb3+-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid, 10-o-aminoanilide (Yb-DO3A-oAA suggested that the aryl amine of the agent forms an intramolecular hydrogen bond with a proximal carboxylate ligand, which was essential for generating a practical chemical exchange saturation transfer (CEST effect from an amine. A ratio of CEST effects from the aryl amine and amide was linearly correlated with pH throughout the physiologic pH range. The pH calibration was used to produce a parametric pH map of a subcutaneous flank tumor on a mouse model of MCF-7 mammary carcinoma. Although refinements in the in vivo CEST MRI methodology may improve the accuracy of pHe measurements, this study demonstrated that the PARACEST contrast agent can be used to generate parametric pH maps of in vivo tumors with saturation power levels that are not harmful to a mouse model of cancer.

  19. Contraception and HIV / STD infections. (United States)

    Merino, G; Murrieta, S


    Copper-releasing IUDs cause severe dermatitis (e.g., urticarial eruptions and eczema) in copper-sensitive women. Such exposure of subcutaneous areas is a cofactor for HIV infection. The excessive menstrual bleeding that accompanies IUD use and absorption of virions and infected cells in the semen of HIV-infected males by IUD tails facilitates HIV infection. IUD tails have the highest concentration of HIV in infected women. HIV causes cervicitis in HIV-infected women. The cross reactivity between pelvic inflammatory disease (not rare among copper-IUD users) and sexually transmitted diseases (STDs) increases the risk of HIV infection. Having multiple sex partners is a risk factor of HIV/STD infections. IUDs, diaphragms, latex condoms, and spermicides may cause an allergic reaction in men and women. Condoms made of lamb cecum are an option to men who are allergic to latex. The single greatest factor for HIV infections in Africa is chancroid. The sudden increase of syphilis in the US parallels the sudden increase in HIV transmission. Physicians need to consider the following before treating pregnant STD patients with an antibiotic: possible risk to fetus, altered kinetics and etiology of the STDs, and choice, dose, route, and duration of antibiotic treatment. Family planning services should focus on HIV-infected women, so they can avoid pregnancy. Many public health and family planning clinics offer counseling and HIV-antibody testing. Human semen has various subpopulations of leukocytes. Leukocytes that have enveloped sperm can take sperm antigens to the lymphatic system. The great individual variation in frequency of CD4+ lymphoid cells and monocytes/ macrophages is clinically important in infectivity of semen in HIV-positive men. T4+ lymphocytes are in the semen of fertile and infertile men. HIV carriers should wear condoms. Partial inactivation of HIV after 10 minutes in the condom at 37 degrees Celsius occurs, but inactivation varies by trademark.

  20. Spin-locking vs. chemical exchange saturation transfer MRI for investigating chemical exchange process between water and labile metabolite protons (United States)

    Jin, Tao; Autio, Joonas; Obata, Takayuki; Kim, Seong-Gi


    Chemical exchange saturation transfer (CEST) and spin-locking (SL) experiments were both able to probe the exchange process between protons of non-equivalent chemical environments. To compare the characteristics of the CEST and SL approaches in the study of chemical exchange effects, we performed CEST and SL experiments at varied pH and concentrated metabolites with exchangeable amide, amine, and hydroxyl protons at 9.4 T. Our results show that: i) On-resonance SL is most sensitive to chemical exchanges in the intermediate exchange regime and is able to detect hydroxyl and amine protons on a millimolar concentration scale. Off-resonance SL and CEST approaches are sensitive to slow-exchanging protons when an optimal SL or saturation pulse power matches the exchanging rate, respectively. ii) Offset frequency-dependent SL and CEST spectra are very similar, and can be explained well with an SL model recently developed by Trott and Palmer. iii) The exchange rate and population of metabolite protons can be determined from offset-dependent SL or CEST spectra or from on-resonance SL relaxation dispersion measurements. iv) The asymmetry of the magnetization transfer ratio (MTRasym) is highly dependent on the choice of saturation pulse power. In the intermediate exchange regime, MTRasym becomes complicated and should be interpreted with care. PMID:21500270

  1. Spin-locking versus chemical exchange saturation transfer MRI for investigating chemical exchange process between water and labile metabolite protons. (United States)

    Jin, Tao; Autio, Joonas; Obata, Takayuki; Kim, Seong-Gi


    Chemical exchange saturation transfer (CEST) and spin-locking (SL) experiments were both able to probe the exchange process between protons of nonequivalent chemical environments. To compare the characteristics of the CEST and SL approaches in the study of chemical exchange effects, we performed CEST and SL experiments at varied pH and concentrated metabolite phantoms with exchangeable amide, amine, and hydroxyl protons at 9.4 T. Our results show that: (i) on-resonance SL is most sensitive to chemical exchanges in the intermediate-exchange regime and is able to detect hydroxyl and amine protons on a millimolar concentration scale. Off-resonance SL and CEST approaches are sensitive to slow-exchanging protons when an optimal SL or saturation pulse power matches the exchanging rate, respectively. (ii) Offset frequency-dependent SL and CEST spectra are very similar and can be explained well with an SL model recently developed by Trott and Palmer (J Magn Reson 2002;154:157-160). (iii) The exchange rate and population of metabolite protons can be determined from offset-dependent SL or CEST spectra or from on-resonance SL relaxation dispersion measurements. (iv) The asymmetry of the magnetization transfer ratio (MTR(asym)) is highly dependent on the choice of saturation pulse power. In the intermediate-exchange regime, MTR(asym) becomes complicated and should be interpreted with care. Copyright © 2010 Wiley-Liss, Inc.

  2. Synthesis of a probe for monitoring HSV1-tk reporter gene expression using chemical exchange saturation transfer MRI. (United States)

    Bar-Shir, Amnon; Liu, Guanshu; Greenberg, Marc M; Bulte, Jeff W M; Gilad, Assaf A


    In experiments involving transgenic animals or animals treated with transgenic cells, it is important to have a method to monitor the expression of the relevant genes longitudinally and noninvasively. An MRI-based reporter gene enables monitoring of gene expression in the deep tissues of living subjects. This information can be co-registered with detailed high-resolution anatomical and functional information. We describe here the synthesis of the reporter probe, 5-methyl-5,6-dihydrothymidine (5-MDHT), which can be used for imaging of the herpes simplex virus type 1 thymidine kinase (HSV1-tk) reporter gene expression in rodents by MRI. The protocol also includes data acquisition and data processing routines customized for chemical exchange saturation transfer (CEST) contrast mechanisms. The dihydropyrimidine 5-MDHT is synthesized through a catalytic hydrogenation of the 5,6-double bond of thymidine to yield 5,6-dihydrothymidine, which is methylated on the C-5 position of the resulting saturated pyrimidine ring. The synthesis of 5-MDHT can be completed within 5 d, and the compound is stable for more than 1 year.

  3. CDC WONDER: Sexually Transmitted Disease (STD) Morbidity (United States)

    U.S. Department of Health & Human Services — The Sexually Transmitted Disease (STD) Morbidity online databases on CDC WONDER contain case reports reported from the 50 United States and D.C., Puerto Rico, Virgin...

  4. CDC WONDER: Sexually Transmitted Disease (STD) morbidity (United States)

    U.S. Department of Health & Human Services — The Sexually Transmitted Disease (STD) Morbidity online databases on CDC WONDER contain case reports reported from the 50 United States and D.C., Puerto Rico, Virgin...

  5. Telling Your Partner You Have an STD (United States)

    ... STD after a confirmed diagnosis may be a criminal offense in some states. Some STDs can affect ... to make decisions about sex or your relationship right away. It's normal to want acceptance and reassurance ...

  6. Chemical Exchange Saturation Transfer MR Imaging Is Superior to Diffusion Tensor Imaging in the Diagnosis and Severity Evaluation of Parkinson's Disease: a Study on Substantia Nigra and Striatum

    Directory of Open Access Journals (Sweden)

    Chunmei eLi


    Full Text Available Parkinson’s disease (PD is a neurodegenerative disorder characterized by nigrostriatal cell loss. To date the diagnosis of PD is still based primarily on the clinical manifestations which may be typical and obvious only in advanced-stage PD. Thus, it is crucial to find a reliable marker for the diagnosis of PD. We conducted this study to assess the diagnostic efficiency of chemical-exchange-saturation-transfer (CEST imaging and diffusion-tensor imaging (DTI in PD at 3 Tesla by evaluating changes on substantia nigra and striatum. Twenty-three PD patients and twenty-three age-matched normal controls were recruited. All patients and controls were imaged on a 3 Tesla MR system, using an 8-channel head coil. CEST imaging was acquired in two transverse slices of the head, including substantia nigra and striatum. The magnetization-transfer-ratio asymmetry at 3.5 ppm, MTRasym(3.5ppm, and the total CEST signal intensity between 0 and 4 ppm were calculated. Multi-slice DTI was acquired for all the patients and normal controls. Quantitative analysis was performed on the substantia nigra, globus pallidus, putamen and caudate. The MTRasym(3.5ppm value, the total CEST signal intensity and fractional anisotropy (FA value of the substantia nigra were all significantly lower in PD patients than in normal controls (P = 0.003, P = 0.004 and P < 0.001, respectively. The MTRasym(3.5ppm values of the putamen and the caudate were significantly higher in PD patients than in normal controls (P = 0.010 and P = 0.009, respectively. There were no significant differences for the mean diffusivity (MD in these four regions between PD patients and normal controls. In conclusion, CEST MR imaging provided multiple CEST image contrasts in the substantia nigra and the striatum in PD and may be superior to DTI in the diagnosis of PD.

  7. Kinetics of intramolecular chemical exchange by initial growth rates of spin saturation transfer difference experiments (SSTD NMR). (United States)

    Quirós, M Teresa; Angulo, Jesús; Muñoz, María Paz


    We report here the Initial Growth Rates SSTD NMR method, as a new powerful tool to obtain the kinetic parameters of intramolecular chemical exchange in challenging small organic and organometallic molecules.

  8. Chemical exchange saturation transfer (CEST) MR technique for in-vivo liver imaging at 3.0 tesla

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Shu-Zhong; Deng, Min; Wang, Yi-Xiang J. [Chinese University of Hong Kong, Prince of Wales Hospital, Department of Imaging and Interventional Radiology, Faculty of Medicine (China); Yuan, Jing [Hong Kong Sanatorium and Hospital, Medical Physics and Research Department, Happy Valley, Hong Kong (China); Wei, Juan [Philips Healthcare Asia, Shanghai (China); Zhou, Jinyuan [Johns Hopkins University, Department of Radiology, Baltimore, MD (United States); Kennedy Krieger Institute, F.M. Kirby Research Center for Functional Brain Imaging, Baltimore, MD (United States)


    To evaluate Chemical Exchange Saturation Transfer (CEST) MRI for liver imaging at 3.0-T. Images were acquired at offsets (n = 41, increment = 0.25 ppm) from -5 to 5 ppm using a TSE sequence with a continuous rectangular saturation pulse. Amide proton transfer-weighted (APTw) and GlycoCEST signals were quantified as the asymmetric magnetization transfer ratio (MTR{sub asym}) at 3.5 ppm and the total MTR{sub asym} integrated from 0.5 to 1.5 ppm, respectively, from the corrected Z-spectrum. Reproducibility was assessed for rats and humans. Eight rats were devoid of chow for 24 hours and scanned before and after fasting. Eleven rats were scanned before and after one-time CCl4 intoxication. For reproducibility, rat liver APTw and GlycoCEST measurements had 95 % limits of agreement of -1.49 % to 1.28 % and -0.317 % to 0.345 %. Human liver APTw and GlycoCEST measurements had 95 % limits of agreement of -0.842 % to 0.899 % and -0.344 % to 0.164 %. After 24 hours, fasting rat liver APTw and GlycoCEST signals decreased from 2.38 ± 0.86 % to 0.67 ± 1.12 % and from 0.34 ± 0.26 % to -0.18 ± 0.37 % respectively (p < 0.05). After CCl4 intoxication rat liver APTw and GlycoCEST signals decreased from 2.46 ± 0.48 % to 1.10 ± 0.77 %, and from 0.34 ± 0.23 % to -0.16 ± 0.51 % respectively (p < 0.05). CEST liver imaging at 3.0-T showed high sensitivity for fasting as well as CCl4 intoxication. (orig.)

  9. A new contrast in MR mammography by means of chemical exchange saturation transfer (CEST) imaging at 3 Tesla: preliminary results. (United States)

    Schmitt, B; Zamecnik, P; Zaiss, M; Rerich, E; Schuster, L; Bachert, P; Schlemmer, H P


    To evaluate the feasibility to detect and delineate malignant breast lesions in human patients by chemical exchange saturation transfer (CEST) as an MR imaging technique without the need for contrast agent administration. Six female patients referred for pre-surgical staging due to histologically confirmed breast cancer were examined with MR at 3 T. The routine breast protocol included T (2w), STIR, T (1w)-DCE and contrast-enhanced T (1w) imaging with SPAIR fat suppression. For CEST imaging, a 3D RF-spoiled gradient echo (GRE) sequence with an optimized saturation pulse train was applied. To assess the diagnostic value of the technique, CEST effects observed between frequency offsets of 1.2 to 1.8 ppm from the bulk water resonance were compared to pharmacokinetic parameter maps (k (ep)) obtained by DCE-MRI. In 3 of 6 patients, regions with high CEST signal intensity correlated well with tumor areas as determined by DCE-MRI. Analysis of signal intensities from ROIs in tumor, fibroglandular, adipose, and muscle tissue revealed significantly higher CEST values in tumor tissue compared to fibroglandular tissue. The detection of lesions was equally well possible with DCE-MRI and CEST-MRI. In the three other patients, the tumor regions could not be delineated based on the CEST image due to artifacts, which were most likely caused by a high content of fat tissue within the ROIs. The results of this initial feasibility study indicate a significant potential of CEST-MRI to discriminate cancer from fibroglandular tissue in the human breast by a CEST contrast generated by endogenous solute molecules. © Georg Thieme Verlag KG Stuttgart · New York.

  10. Cardio-chemical exchange saturation transfer magnetic resonance imaging reveals molecular signatures of endogenous fibrosis and exogenous contrast media. (United States)

    Vandsburger, Moriel; Vandoorne, Katrien; Oren, Roni; Leftin, Avigdor; Mpofu, Senzeni; Delli Castelli, Daniela; Aime, Silvio; Neeman, Michal


    Application of emerging molecular MRI techniques, including chemical exchange saturation transfer (CEST)-MRI, to cardiac imaging is desirable; however, conventional methods are poorly suited for cardiac imaging, particularly in small animals with rapid heart rates. We developed a CEST-encoded steady state and retrospectively gated cardiac cine imaging sequence in which the presence of fibrosis or paraCEST contrast agents was directly encoded into the steady-state myocardial signal intensity (cardioCEST). Development of cardioCEST: A CEST-encoded cardiac cine MRI sequence was implemented on a 9.4T small animal scanner. CardioCEST of fibrosis was serially performed by acquisition of a series of CEST-encoded cine images at multiple offset frequencies in mice (n=7) after surgically induced myocardial infarction. Scar formation was quantified using a spectral modeling approach and confirmed with histological staining. Separately, circulatory redistribution kinetics of the paramagnetic CEST agent Eu-HPDO3A were probed in mice using cardioCEST imaging, revealing rapid myocardial redistribution, and washout within 30 minutes (n=6). Manipulation of vascular tone resulted in heightened peak CEST contrast in the heart, but did not alter redistribution kinetics (n=6). At 28 days after myocardial infarction (n=3), CEST contrast kinetics in infarct zone tissue were altered, demonstrating gradual accumulation of Eu-HPDO3A in the increased extracellular space. cardioCEST MRI enables in vivo imaging of myocardial fibrosis using endogenous contrast mechanisms, and of exogenously delivered paraCEST agents, and can enable multiplexed imaging of multiple molecular targets at high-resolution coupled with conventional cardiac MRI scans. © 2013 American Heart Association, Inc.

  11. The Relationship between STD Locus of Control and STD Acquisition among Adolescent Girls. (United States)

    Rosenthal, Susan L.; Griffith, Jennifer O.; Succop, Paul A.; Biro, Frank M.; Lewis, Lisa M.; DeVellis, Robert F.; Stanberry, Lawrence R.


    Adolescent girls from an urban-based clinic participated in a longitudinal study about psychosexual development and risk of STD acquisition. The girls were asked about their perceptions of loci of control (parents, internal control) as it relates to STD acquisition. Responses to locus of control correlated over time but variations were not found…

  12. National survey of doctors' actions following the diagnosis of a bacterial STD


    McCree, D; Liddon, N; Hogben, M.; St, L


    Methods: A random national sample of 7300 doctors (70% response rate) practising in five medical specialties responded to 13 questions related to STD management. Mean differences across STDs were examined using the General Linear Model function of SPSS.

  13. Mobile health units and STD control. (United States)

    Hall, B


    Sexually transmitted diseases (STDs), especially genital ulcers, facilitate HIV transmission. Prevention and control of STDs could reduce HIV transmission in sub-Saharan Africa where the STD prevalence is still high. The principles of primary health care (PHC) should guide coordinated or integrated AIDS and STD programs in sub-Saharan Africa. WHO recommends implementing the following AIDS prevention and control activities: district-based epidemiological surveillance, education and communication efforts, blood safety, nursing care, counseling, and activities targeting youth, women, and workers at risk. PHC funding is still low in sub-Saharan Africa, even though health professionals have been involved in intensive efforts to mobilize and coordinate national and international financial support for AIDS control programs. Expenditures on infrastructure and training beyond current practical levels are needed to achieve WHO recommendations. The POD from the Shanning Group can address sub-Saharan Africa's problems with using mobile clinic/laboratory facilities. The major problems are cost and difficult terrain. The POD is a modular demountable unit that can be removed from the vehicle for use as a self-supporting facility. The vehicle is then free for other uses. The POD's uses span from a simple examination and STD treatment facility to a sophisticated laboratory conducting basic STD testing as well as HIV and hepatitis ELISA testing. In fact, the POD can serve both roles simultaneously. The Shanning Group also has an audio-visual POD which can present STD educational material to a wide audience.

  14. Chemical-exchange-saturation-transfer magnetic resonance imaging to map gamma-aminobutyric acid, glutamate, myoinositol, glycine, and asparagine: Phantom experiments (United States)

    Oh, Jang-Hoon; Kim, Hyug-Gi; Woo, Dong-Cheol; Jeong, Ha-Kyu; Lee, Soo Yeol; Jahng, Geon-Ho


    The physical and technical development of chemical-exchange-saturation-transfer (CEST) magnetic resonance imaging (MRI) using clinical 3 T MRI was explored with the goal of mapping asparagine (Asn), gamma-aminobutyric acid (GABA), glutamate (Glu), glycine (Gly), and myoinositol (MI), which exist in the brain. Phantoms with nine different conditions at concentrations of 10, 30, and 50 mM and pH values of 5.6, 6.2, and 7.4 were prepared for the five target molecules to evaluate the dependence of the CEST effect in the concentration, the pH, and the amplitude of the applied radiofrequency field B1. CEST images in the offset frequency range of ±6 parts per million (ppm) were acquired using a pulsed radio-frequency saturation scheme with a clinical 3 T MRI system. A voxel-based main magnetic field B0 inhomogeneity correction, where B0 is the center frequency offset at zero ppm, was performed by using the spline interpolation method to fit the full Z-spectrum to estimate the center frequency. A voxel-based CEST asymmetry map was calculated to evaluate amide (-NH), amine (-NH2), and hydroxyl (-OH) groups for the five target molecules. The CEST effect for Glu, GABA, and Gly clearly increased with increasing concentrations. The CEST effect for MI was minimal, with no noticeable differences at different concentrations. The CEST effect for Glu and Gly increased with increasing acidity. The highest CEST asymmetry for GABA was observed at pH 6.2. The CEST effect for Glu, GABA, and Gly increased with increasing B1 amplitude. For all target molecules, the CEST effect for the human 3 T MRI system increased with increasing concentration and B1 amplitude, but varied with pH, depending on the characteristics of the molecules. The CEST effect for MI may be not suitable with clinical MRI systems. These results show that CEST imaging in the brain with the amine protons by using 3 T MRI is possible for several neuronal diseases.

  15. Determinants of communication between partners about STD ...

    African Journals Online (AJOL)

    Determinants of communication between partners about STD symptoms: implications for partner referral in South Africa. ... to have good knowledge about the effects of STDs and the transmission of STDs in the absence of symptoms, had positive attitudes towards condoms and perceived social support for partner referral.

  16. Overview - Be Smart. Be Well. STD Videos

    Centers for Disease Control (CDC) Podcasts


    This video, produced by Be Smart. Be Well., raises awareness of Sexually Transmitted Diseases (STDs): 1) What are they? 2) Why they matter? and, 3) What can I do about them? Footage courtesy of Be Smart. Be Well., featuring CDC's Dr. John Douglas, Division of Sexually Transmitted Disease Prevention.  Created: 3/15/2010 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP).   Date Released: 3/15/2010.

  17. HIV and STD status among MSM and attitudes about Internet partner notification for STD exposure. (United States)

    Mimiaga, Matthew J; Tetu, Ashley M; Gortmaker, Steven; Koenen, Karestan C; Fair, Andrew D; Novak, David S; Vanderwarker, Rodney; Bertrand, Thomas; Adelson, Stephan; Mayer, Kenneth H


    This study assessed the acceptability and perceived utility of Internet-based partner notification (PN) of sexually transmitted disease (STD) exposure for men who have sex with men (MSM) by human immunodeficiency virus (HIV) serostatus. We recruited 1848 US MSM via a banner advertisement posted on an MSM website for meeting sexual partners between October and November 2005. Even though there was broad acceptance of a PN e-mail across HIV serostatus groups, HIV-infected men rated the importance of each component (e.g., information about where to get tested/treated, additional education regarding the STD exposed to, a mechanism for verifying the authenticity of the PN e-mail) lower than HIV-uninfected or status-unknown participants (all P's exposure in the future), and were less likely to inform their partners of possible STD exposure via an Internet notification system in the future (all P's <0.01). A similar trend emerged about men who reported not having a previous STD compared with those who did. Men who reported no previous STD found Internet PN more acceptable. Overall, this study documents broad acceptance of Internet PN by at-risk MSM, regardless of HIV serostatus, including a willingness to receive or initiate PN-related e-mail. If public health officials consider using Internet notification services, they may need to anticipate and address concerns of HIV-infected MSM, and will need to use a culturally-sensitive, social marketing campaign to ensure that those who may benefit from these services are willing to use this modality for PN. Internet PN should be considered as a tool to decrease rising STD and HIV rates among MSM who use the Internet to meet sexual partners.

  18. Examining the themes of STD-related Internet searches to increase specificity of disease forecasting using Internet search terms. (United States)

    Johnson, Amy K; Mikati, Tarek; Mehta, Supriya D


    US surveillance of sexually transmitted diseases (STDs) is often delayed and incomplete which creates missed opportunities to identify and respond to trends in disease. Internet search engine data has the potential to be an efficient, economical and representative enhancement to the established surveillance system. Google Trends allows the download of de-identified search engine data, which has been used to demonstrate the positive and statistically significant association between STD-related search terms and STD rates. In this study, search engine user content was identified by surveying specific exposure groups of individuals (STD clinic patients and university students) aged 18-35. Participants were asked to list the terms they use to search for STD-related information. Google Correlate was used to validate search term content. On average STD clinic participant queries were longer compared to student queries. STD clinic participants were more likely to report using search terms that were related to symptomatology such as describing symptoms of STDs, while students were more likely to report searching for general information. These differences in search terms by subpopulation have implications for STD surveillance in populations at most risk for disease acquisition.

  19. Older partners and STD prevalence among pregnant African American teens. (United States)

    Begley, Elin; Crosby, Richard A; DiClemente, Ralph J; Wingood, Gina M; Rose, Eve


    Several recent studies have addressed the question of whether adolescent females who have sex with older partners have a greater risk of sexually transmitted disease (STD) acquisition. The goal was to identify differences in STD prevalence and selected measures of behavioral risk between unmarried pregnant African American adolescent females reporting sex with older partners and those reporting sex with similar-age partners. Adolescents (n = 169) were recruited during their first prenatal visit. Adolescents completed a self-administered survey and a face-to-face interview and provided urine specimens for nucleic acid amplification assays. Approximately 65% of adolescents reported that their male sex partners were >/=2 years older, while 35% reported having similar-age male sex partners. In age-adjusted analyses, adolescents with older partners were four times more likely to test positive for chlamydia (P pregnant adolescents reporting older partners may be a priority for targeted delivery of partner services. More frequent screening for chlamydia may also be cost-effective for pregnant adolescents with older partners.

  20. Enantioselective binding of a lanthanide(III) complex to human serum albumin studied by 1H STD NMR techniques. (United States)

    Dias, David M; Teixeira, João M C; Kuprov, Ilya; New, Elizabeth J; Parker, David; Geraldes, Carlos F G C


    The enantioselective binding of the (SSS)-Δ isomer of an yttrium(III) tetraazatriphenylene complex to 'drug-site II' of human serum albumin (HSA) was detected by the intensity differences of its STD (1)H NMR spectrum relative to the (RRR)-Λ isomer, by the effect of the competitive binder to that site, N-dansyl sarcosine, upon the STD spectrum of each isomer, in the presence of HSA and by 3D docking simulations.

  1. Determination of an optimally sensitive and specific chemical exchange saturation transfer MRI quantification metric in relevant biological phantoms. (United States)

    Ray, Kevin J; Larkin, James R; Tee, Yee K; Khrapitchev, Alexandre A; Karunanithy, Gogulan; Barber, Michael; Baldwin, Andrew J; Chappell, Michael A; Sibson, Nicola R


    The purpose of this study was to develop realistic phantom models of the intracellular environment of metastatic breast tumour and naïve brain, and using these models determine an analysis metric for quantification of CEST MRI data that is sensitive to only labile proton exchange rate and concentration. The ability of the optimal metric to quantify pH differences in the phantoms was also evaluated. Novel phantom models were produced, by adding perchloric acid extracts of either metastatic mouse breast carcinoma cells or healthy mouse brain to bovine serum albumin. The phantom model was validated using 1 H NMR spectroscopy, then utilized to determine the sensitivity of CEST MRI to changes in pH, labile proton concentration, T1 time and T2 time; six different CEST MRI analysis metrics (MTRasym , APT*, MTRRex , AREX and CESTR* with and without T1 /T2 compensation) were compared. The new phantom models were highly representative of the in vivo intracellular environment of both tumour and brain tissue. Of the analysis methods compared, CESTR* with T1 and T2 time compensation was optimally specific to changes in the CEST effect (i.e. minimal contamination from T1 or T2 variation). In phantoms with identical protein concentrations, pH differences between phantoms could be quantified with a mean accuracy of 0.6 pH units. We propose that CESTR* with T1 and T2 time compensation is the optimal analysis method for these phantoms. Analysis of CEST MRI data with T1 /T2 time compensated CESTR* is reproducible between phantoms, and its application in vivo may resolve the intracellular alkalosis associated with breast cancer brain metastases without the need for exogenous contrast agents. © 2016 The Authors NMR in Biomedicine Published by John Wiley & Sons Ltd.

  2. STD Awareness – Reaching Youth

    Centers for Disease Control (CDC) Podcasts


    In this podcast, Dr. Gail Bolan, Director of CDC's Division of STD Prevention, discusses the problem of STDs in young people, 15-24, and what providers can do.  Created: 4/16/2012 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP).   Date Released: 4/16/2012.

  3. Migration, behaviour change and HIV/STD risks in China. (United States)

    Yang, X; Derlega, V J; Luo, H


    This paper examines if and how temporary migration increases the risk for HIV/STDs in China. Results suggest that temporary migrants had significantly higher prevalence of HIV-risk sexual and drug using behaviours but no significant differences were found between migrants and non-migrants in prevalence of HIV/STDs. Employing logistic regression analysis, we examined three mechanisms--lax social control, social isolation and migrant selectivity--by which the process of migration may lead to behaviour changes that increase migrants' HIV/STD risks. Results indicate that post-migration lax social control was the most significant mediating factor between migration and HIV risk behaviours. Temporary migrants are at high risk of HIV/STDs. Prevention interventions need to pay particular attention to migrants' post-migration lax social control.

  4. Analytical solution for the depolarization of hyperpolarized nuclei by chemical exchange saturation transfer between free and encapsulated xenon (HyperCEST). (United States)

    Zaiss, Moritz; Schnurr, Matthias; Bachert, Peter


    We present an analytical solution of the Bloch-McConnell equations for the case of chemical exchange saturation transfer between hyperpolarized nuclei in cavities and in solvent (HyperCEST experiment). This allows quantitative investigation of host-guest interactions by means of nuclear magnetic resonance spectroscopy and, due to the strong HyperCEST signal enhancement, even NMR imaging. Hosts of interest can be hydrophobic cavities in macromolecules or artificial cages like cryptophane-A which was proposed as a targeted biosensor. Relevant system parameters as exchange rate and host concentration can be obtained from the monoexponential depolarization process which is shown to be governed by the smallest eigenvalue in modulus. For this dominant eigenvalue we present a useful approximation leading to the depolarization rate for the case of on- and off-resonant irradiation. It is shown that this rate is a generalization of the longitudinal relaxation rate in the rotating frame. We demonstrate for the free and cryptophane-A-encapsulated xenon system, by comparison with numerical simulations, that HyperCEST experiments are precisely described in the valid range of this widely applicable analytical approximation. Altogether, the proposed analytical solution allows optimization and quantitative analysis of HyperCEST experiments but also characterization and optimal design of possible biosensors.

  5. Developing a Motion Comic for HIV/STD Prevention for Young People Ages 15-24, Part 2: Evaluation of a Pilot Intervention. (United States)

    Willis, Leigh A; Kachur, Rachel; Castellanos, Ted J; Nichols, Kristen; Mendoza, Maria C B; Gaul, Zaneta J; Spikes, Pilgrim; Gamayo, Ashley C; Durham, Marcus D; LaPlace, Lisa; Straw, Julie; Staatz, Colleen; Buge, Hadiza; Hogben, Matthew; Robinson, Susan; Brooks, John; Sutton, Madeline Y


    In the United States, young people (ages 15-24 years) are disproportionately affected by human immunodeficiency virus (HIV) and other sexually transmitted diseases (STDs), due at least in part to inadequate or incorrect HIV/STD-related knowledge, attitudes, beliefs, and behavioral intentions (KABI). Comic book narratives are a proven method of HIV/STD prevention communication to strengthen KABI for HIV/STD prevention. Motion comics, a new type of comic media, are an engaging and low-cost means of narrative storytelling. The objective of this study was to quantitatively evaluate the effectiveness of a pilot six-episode HIV/STD-focused motion comic series to improve HIV/STD-related KABI among young people. We assessed change in HIV/STD knowledge, HIV stigma, condom attitudes, HIV/STD testing attitudes, and behavioral intentions among 138 participants in 15 focus groups immediately before and after viewing the motion comic series. We used paired t-tests and indicators of overall improvement to assess differences between surveys. We found a significant decrease in HIV stigma (p comic intervention improved HIV/STD-related KABI of young adult viewers by reducing HIV stigma and increasing behavioral intentions to engage in safer sex. Our results demonstrate the promise of this novel intervention and support its use to deliver health messages to young people.

  6. STD patients’ preferences for HIV prevention strategies

    Directory of Open Access Journals (Sweden)

    Castro JG


    Full Text Available Jose G Castro,1 Deborah L Jones,2 Stephen M Weiss2 1Infectious Diseases, Department of Medicine, 2Department of Psychiatry and Behavioral Sciences, University of Miami, Miami, FL, USA Abstract: The objective of this pilot study was to explore the knowledge of and preferences regarding effective biomedical interventions among high risk individuals attending a sexually transmitted diseases clinic, and to examine the effect of a brief information intervention on preference. Participants completed a baseline assessment, attended a presentation on human immunodeficiency virus (HIV prevention methods, and completed a postintervention assessment. Outcome measures included: demographics and sexual risk factors, self-perceived HIV risk, and knowledge and attitudes regarding new biomedical methods of HIV prevention. After the baseline evaluation, participants were provided with information on new biomedical prevention strategies. Participants were given the option to review the information by reading a pamphlet or by viewing a brief video containing the same information. Participants (n=97 were female (n=51 and male (n=46. At baseline, only a small minority of participants were aware of the newer biomedical strategies to prevent HIV infection. Postintervention, 40% endorsed having heard about the use of HIV medications to prevent HIV infection; 72% had heard that male circumcision can decrease the risk of acquiring HIV infection in men; and 73% endorsed knowledge of the potential role of microbicides in decreasing the risk of acquiring HIV. Following the intervention, the most preferred prevention method was male condoms, followed by preexposure prophylaxis, and microbicides. The least preferred methods were male circumcision and female condoms. This study provides preliminary information on knowledge and attitudes regarding newer biomedical interventions to protect against HIV infection. Keywords: STD clinic, biomedical HIV prevention, PrEP, male

  7. A STD/HIV prevention trial among adolescents in managed care. (United States)

    Boekeloo, B O; Schamus, L A; Simmens, S J; Cheng, T L; O'Connor, K; D'Angelo, L J


    To determine if sexually transmitted diseases (STDs), including human immunodeficiency virus (HIV) infection, risk assessment, and education tools provided as part of office-based primary care reduce adolescent risky sexual behaviors. A randomized intervention trial with 3- and 9-month follow-up. Five staff-model managed care sites in Washington, DC (n = 19 pediatricians). Consecutive 12- to 15-year-olds receiving a general health examination; 81% minority. Participation rate = 215/432 (50%). Nine-month follow-up rate = 197/215 (92%). Audiotaped STD risk assessment and education about staying safe (safer = condoms, safest = abstinence). Adolescent-reported sexual intercourse and condom use. More intervention adolescents reported pediatrician discussion on 11/13 sexual topics. Although more vaginal intercourse (odds ratio [OR] = 2.46, 95% confidence interval [CI] = 1.04-5.84) was reported in the intervention group at 3 months, this was not true of overall sexual intercourse (OR = 1.55, 95% CI =.73-3.32). More sexually active adolescents reported condom use in the intervention group at 3 months (OR = 18.05, 95% CI = 1.27-256.03). At 9 months, there were no group differences in sexual behaviors; however, more signs of STD were reported by the control (7/103) than the intervention group (0/94). STD risk assessment and education tools administered in a single office visit facilitated STD/HIV prevention education. Any impact on sexual activity and condom use was short-lived. Further research is needed to develop brief, office-based sexual risk reduction for young adolescents.

  8. An audit of Colposcopy referrals from a GU/STD clinic.

    LENUS (Irish Health Repository)

    O'Connor, Catherine


    BACKGROUND: Cervical cancer is increasing at 1.5% per year in Ireland with 50% mortality giving 2.2% of all cancer deaths. In the Mid-West region a pilot screening programme has begun to screen all women 25-60 years. 66% of Genitourinary\\/Sexually transmitted disease (GU\\/STD) clinics\\' abnormal smears are <25 years. Requests to abandon "opportunistic" screening prompted this GU\\/STD clinic audit. METHODS: 221(8.4%) patients referred to colposcopy over 4 years were audited. Retrospective analysis was carried out on GU\\/STD clinic files, hospital files and computer records for biopsy reports. Ethical approval was prospectively granted. RESULTS: 2637 smears were carried out from November 1999 - September 2003.221 patients referred to colposcopy were audited.1%, 3%, 5% had severe, moderate and, mild dyskaryosis, respectively, on cervical screening while 0.8%, 1.2%, 1.5% had CIN3, CIN2, CIN1 abnormalities, respectively, on biopsy with 3.5% having no abnormality (Cervical Intraepithelial Neoplasia = CIN).53% referred to colposcopy were <25 years. CONCLUSION: 2% had high grade lesions. 37% of high grade lesions are <25 years.Of the high grade lesions 13% had Chlamydia trachomatis (27% of CIN3) and 44% had HPV despite Relative Risks (RR) being 0.75 and 1.09 respectively. Older women had higher grade changes. No statistical difference was found for progression, regression and persistence in those over and under 25.

  9. The Contraceptive Needs for STD Protection among Women in Jail (United States)

    Oswalt, Krista; Hale, Galen J.; Cropsey, Karen L.; Villalobos, Gabriella C.; Ivey, Sara E.; Matthews, Catherine A.


    We assessed the contraceptive needs of women in jails and their sexually transmitted disease (STD) history and risk to determine effective contraceptive methods for this population. A survey of demographics, sexual health, contraceptive use, and preferred method of contraception was completed by participants recruited at jails in a medium-sized…

  10. Using smartphone apps in STD interviews to find sexual partners. (United States)

    Pennise, Melissa; Inscho, Roxana; Herpin, Kate; Owens, John; Bedard, Brenden A; Weimer, Anita C; Kennedy, Byron S; Younge, Mary


    Smartphone applications (apps) are increasingly used to facilitate casual sexual relationships, increasing the risk of sexually transmitted diseases (STDs). In STD investigations, traditional contact elicitation methods can be enhanced with smartphone technology during field interviews. In 2013, the Monroe County Department of Public Health conducted a large, multi-infection STD investigation among men who have sex with men (MSM) using both index case and cluster interviews. When patients indicated meeting sexual partners online, disease intervention specialists (DISs) had access to smartphone apps and were able to elicit partners through access to inboxes and profiles where traditional contact information was lacking. Social network mapping was used to display the extent of the investigation and the impact of access to smartphones on the investigation. A total of 14 index patient interviews and two cluster interviews were conducted; 97 individuals were identified among 117 sexual dyads. On average, eight partners were elicited per interview (range: 1-31). The seven individuals who used apps to find partners had an average of three Internet partners (range: 1-5). Thirty-six individuals either had a new STD (n=7) or were previously known to be HIV-positive (n=29). Of the 117 sexual dyads, 21 (18%) originated either online (n=8) or with a smartphone app (n=13). Of those originating online or with a smartphone app, six (29%) partners were located using the smartphone and two (10%) were notified of their exposure via a website. Three of the new STD/HIV cases were among partners who met online. Smartphone technology used by DISs in the field improved contact elicitation and resulted in successful partner notification and case finding.

  11. HIV/AIDS/STD prevention intervention messages: An evaluation of ...

    African Journals Online (AJOL)

    The aim of this study is to evaluate HIV/AIDS/STD prevention intervention messages on a rural adult (25-49 years) sample in South Africa over a period of 15 months. A representative community sample of 398 adults at time 1 and 382 at time 2 (25-49 years) participated in the study using a three-stage cluster sampling ...

  12. Ida's Story - Be Smart. Be Well. STD Videos

    Centers for Disease Control (CDC) Podcasts


    This video, produced by Be Smart. Be Well., raises awareness of Sexually Transmitted Diseases (STDs): 1) What are they? 2) Why they matter? and, 3) What can I do about them? Footage courtesy of Be Smart. Be Well., featuring CDC's Dr. John Douglas, Division of Sexually Transmitted Disease Prevention.  Created: 3/15/2010 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP).   Date Released: 3/15/2010.

  13. Street Stories - Be Smart. Be Well. STD Videos

    Centers for Disease Control (CDC) Podcasts


    This video, produced by Be Smart. Be Well., raises awareness of Sexually Transmitted Diseases (STDs): 1) What are they? 2) Why they matter? and, 3) What can I do about them? Footage courtesy of Be Smart. Be Well.  Created: 3/15/2010 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP).   Date Released: 3/15/2010.

  14. What Is It? - Be Smart. Be Well. STD Videos

    Centers for Disease Control (CDC) Podcasts


    This video, produced by Be Smart. Be Well., raises awareness of Sexually Transmitted Diseases (STDs): 1) What are they? 2) Why they matter? and, 3) What can I do about them? Footage courtesy of Be Smart. Be Well., featuring CDC's Dr. John Douglas, Division of Sexually Transmitted Disease Prevention.  Created: 3/15/2010 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP).   Date Released: 3/15/2010.

  15. Molly's Story - Be Smart. Be Well. STD Videos

    Centers for Disease Control (CDC) Podcasts


    This video, produced by Be Smart. Be Well., raises awareness of Sexually Transmitted Diseases (STDs): 1) What are they? 2) Why they matter? and, 3) What can I do about them? Footage courtesy of Be Smart. Be Well.  Created: 3/15/2010 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP).   Date Released: 3/15/2010.

  16. STD and HIV risk factors among U.S. young adults: variations by gender, race, ethnicity and sexual orientation. (United States)

    Mojola, Sanyu A; Everett, Bethany


    STDs, including HIV, disproportionately affect individuals who have multiple minority identities. Understanding differences in STD risk factors across racial, ethnic and sexual minority groups, as well as genders, is important for tailoring public health interventions. Data from Waves 3 (2001-2002) and 4 (2007-2008) of the National Longitudinal Study of Adolescent Health were used to develop population-based estimates of STD and HIV risk factors among 11,045 young adults (mean age, 29 at Wave 4), by gender, race and ethnicity, and sexual orientation (heterosexual, mixed-oriented, gay). Regression analyses were conducted to examine associations between risk factors and young adults' characteristics. Overall, sexual-minority women in each racial or ethnic group had a higher prevalence of sexual risk behaviors-including a history of multiple partners, forced sex and incarceration-than their heterosexual counterparts. Mixed-oriented women in each racial or ethnic group were more likely than heterosexual white women to have received an STD diagnosis (odds ratios, 1.8-6.4). Black men and sexual-minority men also appeared to be at heightened risk. Gay men in all racial and ethnic groups were significantly more likely than heterosexual white men to report having received an STD diagnosis (2.3-8.3); compared with heterosexual white men, mixed-oriented black men had the highest odds of having received such a diagnosis (15.2). Taking account of multiple minority identities should be an important part of future research and intervention efforts for STD and HIV prevention. Copyright © 2012 by the Guttmacher Institute.

  17. A study on sexually transmitted diseases in patients in a STD clinic in a district hospital in North India

    Directory of Open Access Journals (Sweden)

    Neerja Puri


    Full Text Available Introduction: The Sexually transmitted diseases (STDs are a global health problem of great magnitude. The pattern of STDs differs from country to country and from region to region. The increased risk of the transmission of HIV is known to be associated with the presence of sexually transmitted diseases (STDs and despite the presence of the National STD Control Program in India the number of people with STDs remains high. Aim: The aim of our study was to study the profile of patients in a STD clinic in North India and to study various sexually transmitted infections in both male and female patients. Material and Methods: A prospective study of the patients attending STD clinic in a district hospital in North India from December 2009 to December 2012 was done. A total of 2700 patients attending the STDclinic in three years from December 2009 to December 2012 were taken up for the study. Results: The commonest sexually transmitted infection in males was herpes genitalis (30% followed by 20% cases of genital warts. 10% patients had gonorrhoea, genital molluscum contagiosum, syphilis and genital scabies each and 5% patients had nongonococcal urethritis. Only 5% of the total patients had chancroid, donovanosis and LGV. The commonest sexually transmitted infection in females was vaginal discharge seen in 40% patients, lower abdominal pain in 20% patients, herpes genitalis in 15% patients followed by 20% cases of genital warts and syphilis each. Genital molluscum contagiosum was seen in 5% patients only. Conclusions: The treatment of STD’s is important as both non-ulcerative and ulcerative STDs increase the susceptibility to or transmissibility of HIV infection and as such, an increase in STD prevalence as revealed by clinic attendance in this study was bound to facilitate the spread of HIV/AIDS. Perhaps it is high time health planners adopted a more aggressive and result oriented HIV/AIDS/STD awareness campaign strategy.

  18. Saturation transfer EPR (ST-EPR) for dating biocarbonates containing large amount of Mn{sup 2+}: separation of SO{sub 3}{sup -} and CO{sub 2}{sup -} lines and geochronology of Brazilian fish fossil

    Energy Technology Data Exchange (ETDEWEB)

    Sastry, M.D.; Andrade, M.B.; Watanabe, Shigueo E-mail:


    A method using saturation transfer EPR (ST-EPR) is shown to be feasible for detecting EPR signal of radiation-induced defects in biocarbonates containing large amount of Mn{sup 2+}. The ST-EPR measurements conducted at room temperature on fish fossil of Brazilian origin, enabled the identification of CO{sub 2}{sup -} and SO{sub 3}{sup -} radical ions, by partially suppressing the intense signal from Mn{sup 2+} when the signal are detected 90 deg. out of phase with magnetic field modulating signal and at high microwave power (50 mW). Using these signals the age of fish fossil is estimated to be (36{+-}5) Ma.

  19. Selection of populations represented in the NIMH Collaborative HIV/STD Prevention Trial. (United States)


    To identify venues with vulnerable populations suitable for testing the community popular opinion leader intervention in each of the five countries (China, India, Peru, Russia, and Zimbabwe) participating in the National Institute of Mental Health (NIMH) Collaborative HIV/STD Prevention Trial. HIV epidemiology and vulnerable populations differ considerably across the countries. Therefore, different community populations were targeted in the five countries. Venues and populations were chosen on the basis of specific selection criteria (investigated during the Trial's ethnographic research phase): the willingness of stakeholders and gatekeepers of the venues to cooperate; geographical boundaries defining each venue; population stability within venues; the independence of venues and non-overlap of population members across multiple venues; population size within each venue; social interaction opportunities; and either a high level of sexual risk behavior or a high prevalence of sexually transmitted diseases (STDs) or HIV. Venues and populations selected were food market stall owners and workers in China, male patrons of wine shops and at-risk women congregating near the shops in India, young men and women in social gathering points in neighborhoods in Peru, trade and vocational school dormitory residents in Russia, and people congregating in growth points in Zimbabwe. Although the target populations differed across countries, they shared in common high behavioral or biological risk at baseline and suitability for a randomized trial of a community-level HIV/STD prevention behavioral intervention.

  20. NASA-STD 3001 and the Human Integration Design Handbook (HIDH): Evolution of NASA-STD-3000 (United States)

    Pickett, Lynn; Connolly, Janis; Arch, M.; Tillman, Barry; Russo, Dane


    The Habitability & Environmental Factors and Space Medicine Divisions have developed the Space Flight Human System Standard (SFHSS) (NASA-STD-3001) to replace NASA-STD-3000 as a new NASA standard for all human spaceflight programs. The SFHSS is composed of 2 volumes. Volume 1, Crew Health, contains medical levels of care, permissible exposure limits, and fitness for duty criteria, and permissible outcome limits as a means of defining successful operating criteria for the human system. Volume 2, Habitability and Environmental Health, contains environmental, habitability and human factors standards. Development of the Human Integration Design Handbook (HIDH), a companion to the standard, is currently under construction and entails the update and revision of NASA-STD-3000 data. This new handbook will, in the fashion of NASA STD-3000, assist engineers and designers in appropriately applying habitability, environmental and human factors principles to spacecraft design. Organized in a chapter-module-element structure, the HIDH will provide the guidance for the development of requirements, design considerations, lessons learned, example solutions, background research, and assist in the identification of gaps and research needs in the disciplines. Subject matter experts have been and continue to be solicited to participate in the update of the chapters. The purpose is to build the HIDH with the best and latest data, and provide a broad representation from experts in industry, academia, the military and the space program. The handbook and the two standards volumes work together in a unique way to achieve the required level of human-system interface. All new NASA programs will be required to meet Volumes 1 and 2. Volume 2 presents human interface goals in broad, non-verifiable standards. Volume 2 also requires that each new development program prepare a set of program-specific human factors requirements. These program-specific human and environmental factors requirements

  1. An audit of Colposcopy referrals from a GU/STD clinic

    Directory of Open Access Journals (Sweden)

    Ryan Ailis


    Full Text Available Abstract Background Cervical cancer is increasing at 1.5% per year in Ireland with 50% mortality giving 2.2% of all cancer deaths. In the Mid-West region a pilot screening programme has begun to screen all women 25–60 years. 66% of Genitourinary/Sexually transmitted disease (GU/STD clinics' abnormal smears are Methods 221(8.4% patients referred to colposcopy over 4 years were audited. Retrospective analysis was carried out on GU/STD clinic files, hospital files and computer records for biopsy reports. Ethical approval was prospectively granted. Results 2637 smears were carried out from November 1999 – September 2003. 221 patients referred to colposcopy were audited. 1%, 3%, 5% had severe, moderate and, mild dyskaryosis, respectively, on cervical screening while 0.8%, 1.2%, 1.5% had CIN3, CIN2, CIN1 abnormalities, respectively, on biopsy with 3.5% having no abnormality (Cervical Intraepithelial Neoplasia = CIN. 53% referred to colposcopy were Conclusion 2% had high grade lesions. 37% of high grade lesions are Of the high grade lesions 13% had Chlamydia trachomatis (27% of CIN3 and 44% had HPV despite Relative Risks (RR being 0.75 and 1.09 respectively. Older women had higher grade changes. No statistical difference was found for progression, regression and persistence in those over and under 25.

  2. Reducing offensiveness of STD prevention advertisements in China. (United States)

    Waller, David S; Fam, Kim-Shyan


    The issue of sexually transmitted diseases is a socially sensitive one in Asian communities, with governments being criticized for not doing enough to reduce AIDS transmission, and the advertising of such issues potentially causing offense to people. This article surveys 630 people in China to determine their level of offense toward the advertising of condoms and STD prevention and analyzes the qualitative responses to how they would reduce the offensiveness of such advertising. The results found that generally women are more offended by the advertising of these products than men, and in terms of creative execution, women prefer implicit, prevention or effects messages, whereas men suggested a scientific message, or a focus on the creative strategy or media/location of the advertisement. It is recommended that traditional Chinese Confucian values are important for public policy makers to keep in mind when wanting to advertise socially sensitive issues in China and wider Asia.

  3. Prevalence and risk factors for hepatitis B virus infections among visitors to an STD clinic

    NARCIS (Netherlands)

    Y.T.H.P. van Duynhoven; M.J.W. van de Laar; W.A. Schop; Ph.H. Rothbarth (Philip); W.I. van der Meijden (Willem); A.M. van Loon (Anton); M.J.W. Sprenger (Marc)


    textabstractObjective: To determine the prevalence and risk factors for hepatitis B virus (HBV) infections among individuals attending an STD clinic in a low endemic region. Study design: A total of 1228 women and 1648 men attending the STD clinic at the University Hospital Rotterdam, Netherlands,

  4. Patient, provider, and clinic characteristics associated with public STD clinic patient satisfaction


    Mehta, S.; Zenilman, J; Erbelding, E


    Objectives: There is a lack of information describing levels of patient satisfaction among patients seeking sexually transmitted diseases (STD) care in a public clinic setting. We sought to identify patient, provider, and clinic characteristics associated with patient satisfaction within public STD clinics.

  5. National STD Awareness Month and GYT: Get Yourself Tested PSA (:60)

    Centers for Disease Control (CDC) Podcasts


    April is National STD Awareness Month. In this PSA, native communities, especially adolescents and young adults, are encouraged to get educated, tested, and treated by visiting  Created: 3/3/2011 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention.   Date Released: 3/3/2011.

  6. Quality control of antibiotics before the implementation of an STD program in Northern Myanmar. (United States)

    Prazuck, Thierry; Falconi, Isabelle; Morineau, Guy; Bricard-Pacaud, Véronique; Lecomte, Antoine; Ballereau, Francoise


    The ready availability of poor-quality drugs in developing countries leads to treatment failure and, consequently, excess mortality and morbidity. Moreover, the widespread availability of substandard drugs plays a key role in increasing the resistance to antimicrobial drugs.GOAL As a prerequisite to the establishment of a sexually transmitted disease (STD) control program, this study aimed to evaluate the quality of antibiotics recommended for treatment of STDs that were locally available in the capital of a province of Northern Myanmar. In addition to the hospital pharmacy, we selected at random 5 of the 41 drug sellers and 5 of the 40 general practitioners who sell antibiotics in the city of Myitkyina. Twenty-one marketing products corresponding to nine different antibiotics used for STD treatment were purchased (benzathine benzylpenicillin, benzylpenicillin, ceftriaxone, chlortetracycline, ciprofloxacin, clotrimazole, co-trimoxazole, doxycycline, and erythromycin). Drugs were sent to France, where they were analyzed according to the WHO guidelines. Drugs were considered to be standard if their dosage remained in the 10% range of the expected value. Among the 21 different specialty products, only three displayed the official "registered" label. Three drugs were expired and the expiration date was not available for six others. One product did not contain the active drug declared (chlortetracycline; Lombisin, Unicorn, China) and did not show any in vitro activity against bacteria. Seven of 21 products (33%) did not contain the stated dosage (1, more than stated dosage; 6, less than stated dosage). The highest deficit observed was 48% in two products (co-trimoxazole, Yong Fong, Myanmar; benzylpenicillin, China [city and manufacturer unknown]). The dosage was not available for five drugs. As a result, only 8 of 21 products (38%) did not contain the stated dosage of active drug. These findings suggest that public health policies based on national treatment guidelines

  7. [Willingness on accepting the short-message-service and factors related to HIV/STD testing among male STD clinic clients]. (United States)

    Meng, Xiaojun; Zou, Huachun; Jia, Tianjian; Zhu, Chen; Chen, Xin; Zhang, Xuan


    To understand the willingness on acceptance of a short-messageservice (SMS) program provided for HIV/STD testing and the related factors, among male clients at the STD clinics in China. Convenience sampling method was used to select study subjects at a STD clinic in Wuxi, Jiangsu province. A questionnaire survey was conducted among the subjects to collect the information on socio-demographic characteristics and willingness of acceptance to the SMS. A total of 368 SMS subjects were surveyed, in which 75.5% expressed the willingness of acceptance, while 57.2% and 38.1% of them wanted to receive the short message every 3 months or 6 months, respectively. 53.8% of the respondents showed their willingness to share the news with their sexual partners about SMS and 44.8% of them would do the same to their friends. Data from the Multivariate logistic regression analysis showed that those who had received senior high school or above education (aOR=3.632, 95%CI: 1.939-6.715) , having homosexual behavior (aOR = 1.973, 95%CI: 1.234-8.358) or those having received AIDS related intervention service in the past year (aOR=9.416, 95%CI: 4.822-18.309) were more likely to accept the SMS. SMS seemed to be acceptable among the male STD clinic clients in Wuxi, suggesting that it is feasible to conduct the SMS as a strategy to improve the HIV/STDs testing program at the STD clinics in the future. Promotion of SMS should be strengthened and the provision of general AIDS intervention service at the STD clinics should be established in order to make more STD clinic clients understand this SMS.

  8. The Importance of School Staff Referrals and Follow-Up in Connecting High School Students to HIV and STD Testing (United States)

    Rasberry, Catherine N.; Liddon, Nicole; Adkins, Susan Hocevar; Lesesne, Catherine A.; Hebert, Andrew; Kroupa, Elizabeth; Rose, India D.; Morris, Elana


    This study examined predictors of having received HIV and sexually transmitted disease (STD) testing and having been referred by school staff for HIV/STD testing. In 2014, students in seven high schools completed paper-and-pencil questionnaires assessing demographic characteristics, sexual behavior, referrals for HIV/STD testing, and HIV/STD…

  9. Lanthanide ion (III) complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaminophosphonate (DOTA-4AmP8−) for dual biosensing of pH with CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts) (United States)

    Huang, Yuegao; Coman, Daniel; Ali, Meser M.; Hyder, Fahmeed


    Relaxivity based magnetic resonance of phosphonated ligands chelated with gadolinium (Gd3+) shows promise for pH imaging. However instead of monitoring the paramagnetic effect of lanthanide complexes on the relaxivity of water protons, biosensor (or molecular) imaging with magnetic resonance is also possible by detecting either the non-exchangeable or the exchangeable protons on the lanthanide complexes themselves. The non-exchangeable protons (e.g., –CHx, where 3≥x≥1) are detected using a three-dimensional chemical shift imaging method called Biosensor Imaging of Redundant Deviation in Shifts (BIRDS), whereas the exchangeable protons (e.g., –OH or –NHy, where 2≥y≥1) are measured with Chemical Exchange Saturation Transfer (CEST) contrast. Here we tested the feasibility of BIRDS and CEST for pH imaging of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaminophosphonate (DOTA-4AmP8−) chelated with thulium (Tm3+) and ytterbium (Yb3+). BIRDS and CEST experiments show that both complexes are responsive to pH and temperature changes. Higher pH and temperature sensitivities are obtained with BIRDS for either complex when using the chemical shift difference between two proton resonances vs. using the chemical shift of a single proton resonance, thereby eliminating the need to use water resonance as reference. While CEST contrast for both agents is linearly dependent on pH within a relatively large range (i.e., 6.3-7.9), much stronger CEST contrast is obtained with YbDOTA-4AmP5− than with TmDOTA-4AmP5−. In addition, we demonstrate the prospect of using BIRDS to calibrate CEST as new platform for quantitative pH imaging. PMID:24801742

  10. Application of localized {sup 31}P MRS saturation transfer at 7 T for measurement of ATP metabolism in the liver: reproducibility and initial clinical application in patients with non-alcoholic fatty liver disease

    Energy Technology Data Exchange (ETDEWEB)

    Valkovic, Ladislav [Medical University of Vienna, High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Vienna (Austria); Slovak Academy of Sciences, Department of Imaging Methods, Institute of Measurement Science, Bratislava (Slovakia); Gajdosik, Martin; Chmelik, Marek; Trattnig, Siegfried [Medical University of Vienna, High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Vienna (Austria); Traussnigg, Stefan; Kienbacher, Christian; Trauner, Michael [Medical University of Vienna, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Vienna (Austria); Wolf, Peter; Krebs, Michael [Medical University of Vienna, Division of Endocrinology and Metabolism, Department of Internal Medicine III, Vienna (Austria); Bogner, Wolfgang [Medical University of Vienna, High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Vienna (Austria); Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA (United States); Krssak, Martin [Medical University of Vienna, High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Vienna (Austria); Medical University of Vienna, Division of Endocrinology and Metabolism, Department of Internal Medicine III, Vienna (Austria)


    Saturation transfer (ST) phosphorus MR spectroscopy ({sup 31}P MRS) enables in vivo insight into energy metabolism and thus could identify liver conditions currently diagnosed only by biopsy. This study assesses the reproducibility of the localized {sup 31}P MRS ST in liver at 7 T and tests its potential for noninvasive differentiation of non-alcoholic fatty liver (NAFL) and steatohepatitis (NASH). After the ethics committee approval, reproducibility of the localized {sup 31}P MRS ST at 7 T and the biological variation of acquired hepato-metabolic parameters were assessed in healthy volunteers. Subsequently, 16 suspected NAFL/NASH patients underwent MRS measurements and diagnostic liver biopsy. The Pi-to-ATP exchange parameters were compared between the groups by a Mann-Whitney U test and related to the liver fat content estimated by a single-voxel proton ({sup 1}H) MRS, measured at 3 T. The mean exchange rate constant (k) in healthy volunteers was 0.31 ± 0.03 s{sup -1} with a coefficient of variation of 9.0 %. Significantly lower exchange rates (p < 0.01) were found in NASH patients (k = 0.17 ± 0.04 s{sup -1}) when compared to healthy volunteers, and NAFL patients (k = 0.30 ± 0.05 s{sup -1}). Significant correlation was found between the k value and the liver fat content (r = 0.824, p < 0.01). Our data suggest that the {sup 31}P MRS ST technique provides a tool for gaining insight into hepatic ATP metabolism and could contribute to the differentiation of NAFL and NASH. (orig.)

  11. Observing and preventing rubidium runaway in a direct-infusion xenon-spin hyperpolarizer optimized for high-resolution hyper-CEST (chemical exchange saturation transfer using hyperpolarized nuclei) NMR. (United States)

    Witte, C; Kunth, M; Rossella, F; Schröder, L


    Xenon is well known to undergo host-guest interactions with proteins and synthetic molecules. As xenon can also be hyperpolarized by spin exchange optical pumping, allowing the investigation of highly dilute systems, it makes an ideal nuclear magnetic resonance probe for such host molecules. The utility of xenon as a probe can be further improved using Chemical Exchange Saturation Transfer using hyperpolarized nuclei (Hyper-CEST), but for highly accurate experiments requires a polarizer and xenon infusion system optimized for such measurements. We present the design of a hyperpolarizer and xenon infusion system specifically designed to meet the requirements of Hyper-CEST measurements. One key element of this design is preventing rubidium runaway, a chain reaction induced by laser heating that prevents efficient utilization of high photon densities. Using thermocouples positioned along the pumping cell we identify the sources of heating and conditions for rubidium runaway to occur. We then demonstrate the effectiveness of actively cooling the optical cell to prevent rubidium runaway in a compact setup. This results in a 2-3-fold higher polarization than without cooling, allowing us to achieve a polarization of 25% at continuous flow rates of 9 ml/min of (129)Xe. The simplicity of this design also allows it to be retrofitted to many existing polarizers. Combined with a direction infusion system that reduces shot-to-shot noise down to 0.56% we have captured Hyper-CEST spectra in unprecedented detail, allowing us to completely resolve peaks separated by just 1.62 ppm. Due to its high polarization and excellent stability, our design allows the comparison of underlying theories of host-guest systems with experiment at low concentrations, something extremely difficult with previous polarizers.

  12. Correlating the EMC analysis and testing methods for space systems in MIL-STD-1541A (United States)

    Perez, Reinaldo J.

    A study was conducted to improve the correlation between the electromagnetic compatibility (EMC) analysis models stated in MIL-STD-1541A and the suggested testing methods used for space systems. The test and analysis methods outlined in MIL-STD-1541A are described, and a comparative assessment of testing and analysis techniques as they relate to several EMC areas is presented. Suggestions on present analysis and test methods are introduced to harmonize and bring the analysis and testing tools in MIL-STD-1541A into closer agreement. It is suggested that test procedures in MIL-STD-1541A must be improved by providing alternatives to the present use of shielded enclosures as the primary site for such tests. In addition, the alternate use of anechoic chambers and open field test sites must be considered.

  13. A study on the present scenario of STD management in an urban clinic in Kolkata

    Directory of Open Access Journals (Sweden)

    Ghosh Sadhan Kumar


    Full Text Available A total of 4129 patients attended the STD clinic from 1996 to 1999. Of those 25.75% were STD cases. Male and female cases comprised 86% and 14% respectively. Majority were in the age group between 18 to 38 years. Choncroid was the commonest STD (37. 7%. Other STDs in order were syphilis (30. 66%, NGU (15.71%, gonorrhoea (7%, venereal wart (3.57%, candidiasis (2.53%, trichomonal vaginitis (1.6%, herpes genitalis (0.65% and LGV (0.47%. No case of Donovanosis or HIV was detected. 13.7% of STD cases were reactive for VDRL test and 8% of the antenatal attendents were strongly VDRL test reactive. The urethral discharge on gram staining was positive for gonococcus, in 29%. 68% of the clinic attendents were given safer sex education and served condom.

  14. A descriptive analysis of STD prevalence among urban pregnant African-American teens: data from a pilot study. (United States)

    Diclemente, Ralph J; Wingood, Gina M; Crosby, Richard A; Rose, Eve; Lang, Delia; Pillay, Allan; Papp, John; Faushy, Carol


    To assess the prevalence of sexually transmitted diseases (STDs) among a sample of African-American adolescent females at the time of their first prenatal visit and to assess key characteristics of those testing positive for sexually transmitted diseases. The study also determined differences in these characteristics between adolescents who were and those who were not diagnosed with an STD. One-hundred-and-seventy pregnant African-American adolescents (aged 14-20 years; mean = 17.5 years) receiving their first prenatal visit were recruited at a prenatal clinic located in a large urban hospital. Biological assessment included nucleic acid amplification testing for gonococcal, chlamydial, and trichomonal infections. Rapid plasma reagin testing assessed infection with syphilis. A self-administered survey and in-depth face-to-face interview were used to collect detailed information assessing adolescents' sociodemographic characteristics, psychosocial indices, and their recent sexual risk behaviors. Data were analyzed using Student's t-tests and contingency table analyses, respectively, for continuous and categorical variables. Overall, 23.5% tested positive for one of the four STDs. Thirteen percent were infected with Chlamydia trachomatis, 1.2% with Neisseria gonorrhoeae, 8.9% with Trichomonas vaginalis, and 1.2% with Treponema pallidum. More than one-half reported recent (past 6 months) treatment for an STD, 30% of these tested positive for at least one of the four STDs assessed. Adolescents testing positive for STDs held favorable attitudes toward condom use, but levels of sexual risk were generally high. There were no sociodemographic, psychosocial, and sexual-risk differences between those testing positive and negative. Findings support STD screening efforts targeting pregnant adolescents. Providing clinic-based counseling and prevention education programs to pregnant adolescents regardless of apparent risk factors may also be warranted.

  15. STD knowledge and behaviours among clients of female sex workers in Bali, Indonesia. (United States)

    Fajans, P; Wirawan, D N; Ford, K


    This study investigated knowledge, beliefs, and practices related to STDs and AIDS among clients of low price sex workers in Bali, Indonesia. These men are at high risk of STD and HIV transmission. They have poor knowledge of the basic concepts of STD and HIV transmission and prevention, and they practice a variety of ineffective prevention strategies including partner selection and the prophylactic use of antibiotics. They report a mean of 1.9 paid sexual partners in the previous week and very low frequencies of condom use. Over 25% had experienced an STD symptom in the previous 6 months, with self treatment with antibiotics reported by a third. Recent experience of an STD was related to the number of sex worker partners in the previous month and to ever having used a condom with a sex worker. The implications of the study findings for the development of comprehensive STD control programs including educational campaigns, condom promotion, and the strengthening of STD case management by health care providers are discussed.

  16. [Prevalence of sexually transmitted diseases (STD) in HIV positive women in southern Israel]. (United States)

    Banani, Shirli; Schlaeffer, Francisc; Leibenson, Lilach; Saidel-Odes, Lisa; Shemer, Yonat; Sagi, Orly; Borer, Abraham; Riesenberg, Klaris


    Co-infection of HIV and other sexualLy transmitted diseases (STDs) is common. The Centers for Disease Control and Prevention (CDC) recommends routine yearly screening for STDs in HIV carriers. There is only scarce data on the prevalence of STD in HIV positive individuals in Israel and no current recommendations on this issue are available. To evaluate the prevalence of STDs, in HIV positive females attending the HIV Clinic at the Soroka University Medical Center in Beer Sheva and to compare prevalence and risk factors for STDs between HIV female carriers of Ethiopian and non-Ethiopian origin. Eighty five HIV-positive women were enrolled in the study. Demographic data and sexual behavior were obtained and medical records were reviewed. Cervical swabs for Neisseria gonorrhoeae, Herpes simplex 1 and 2, Ureaplasma urealyticum and Mycoplasma hominis and serum samples for hepatitis B, C and syphilis were obtained. Thirty two of the study participants (37.6%) had at least one STD and in eleven cases (12.9%) two or more STDs were found. Ureaplasma urealyticum was the most frequent pathogen (29.4%). Prevalence for Mycoplasma hominis, HSV1 and 2, Neisseria gonorrhoeae, syphilis and HBV was low. Despite significant differences in sexual behavior between women of Ethiopian and non-Ethiopian origin there were no differences in the prevalence of STDs in the two groups. HCV was significantly more prevalent in women of non-Ethiopian origin, due to high use of intravenous drugs in this group. There was no correlation between CD4 levels and the prevalence of STDs in both groups. A relatively low prevalence of STDs among female HIV carriers was found, despite low condom use. The exclusion of males in this study may have contributed to this. The most frequent pathogen found in this study was asymptomatic Ureaplasma urealyticum (29.4%). As this pathogen may cause premature delivery and fetal death it seems important to routinely screen HIV-positive fertile women for its presence. A

  17. [Community-based intervention to control STD/AIDS in the Amazon region, Brazil]. (United States)

    Benzaken, Adele Schwartz; Galbán Garcia, Enrique; Sardinha, José Carlos Gomes; Pedrosa, Valderiza Lourenço; Paiva, Vera


    To describe a case study of community-based intervention, developed in a constructionist-emancipatory framework to control STD/AIDS. Descriptive study developed in the town of Manacapuru, in the state of Amazonas, from 1997 to 2004, focusing on procedures designed in collaboration with government agents, health professionals and the community. Data on the dynamics of prostitution and condom sales in this town, preventive practices and STD/AIDS care and process assessment were collected. Actions targeting STD prevention and care in the public healthcare system, a testing center, an epidemiological surveillance system and sex workers' qualification were established concomitantly. It was observed the strengthening of sex workers as peer educators and their legitimization as citizens and health agents in projects involving transvestites, homosexuals and students. There was an increase in condom sales in town, as well as in condom use among sex workers; reduction in bacterial STD; and stabilization of the incidence of HIV/AIDS infections and congenital syphilis. The sustainability of the intervention program studied, organized within the sphere of action of the Sistema Unico de Saúde (National Health System), was promoted by a political pact, which guaranteed headquarters and municipal law-regulated budget, as well as by the constant debate over the process and program results. The study strengthened the notion that effective control of STD/AIDS depends on a synergic approach that combines interventions on individual (biological-behavioral), sociocultural and programmatic levels.

  18. "Something of an adventure": postwar NIH research ethos and the Guatemala STD experiments. (United States)

    Spector-Bagdady, Kayte; Lombardo, Paul A


    The STD experiments in Guatemala from 1946-1948 have earned a place of infamy in the history of medical ethics. But if the Guatemala STD experiments were so "ethically impossible," how did the U.S. government approve their funding? Although much of the literature has targeted the failings of Dr. John Cutler, we focus on the institutional context and research ethos that shaped the outcome of the research. After the end of WWII, Dr. Cassius Van Slyke reconstructed the federal research contracts process into a grant program. The inaugural NIH study section recommended approval of the Guatemala STD experiments at its first meeting. The funding and oversight process of the Guatemala research was marked with serious conflicts of interest and a lack of oversight, and it was this structure, as opposed to merely a maleficent individual, that allowed the Guatemala STD experiments to proceed. We conclude that while current research regulations are designed to prevent the abuses perpetrated on the subjects of the Guatemala STD experiments, it takes a comprehensive understanding of research ethics through professional education to achieve the longstanding ideal of the responsible investigator, and ensure ethical research under any regulatory scheme. © 2013 American Society of Law, Medicine & Ethics, Inc.

  19. The characteristics of heterosexual STD clinic attendees who practice oral sex in Zhejiang Province, China.

    Directory of Open Access Journals (Sweden)

    Qiaoqin Ma

    Full Text Available BACKGROUND: The characteristics of heterosexual attendees who visit sexually transmitted disease (STD clinics and practice oral sex have not been revealed in China. This information is important for the development of targeted STD prevention programmes for this population. STUDY DESIGN: A self-administered questionnaire survey with a cross-sectional design was administered to consecutive attendees at four STD clinics in Zhejiang Province, China, between October and December in 2007. Demographic, psychosocial, and behavioural factors associated with oral sex over a lifetime were identified using univariate and multivariate analyses. RESULTS: Of the 872 attendees, 6.9% engaged in oral sex over their lifetimes. Of the oral-sex group, 96.6% also engaged in vaginal sex. The correlates for oral sex over a lifetime as determined by the multivariate analysis were high income (odds ratio [OR] = 2.53, 95% confidence interval [CI] 1.39-4.59, high human immunodeficiency virus (HIV-related knowledge (OR = 2.71, 95% CI 1.26-5.81, early sex initiation (OR = 2.42, 95% CI 1.37-4.27, multiple sexual partners (OR = 3.09, 95% CI 1.58-6.06, and sexually active in the previous 6 months (OR = 7.73, 95% CI 1.04-57.39. CONCLUSIONS: Though the prevalence of oral sex is low, the heterosexual STD clinic attendees practicing oral sex was found to have higher risks associated with STD/HIV transmission than those not. Behavioural and medical interventions conducted by clinicians in Chinese STD clinics should take into account the characteristics and related risks of those who practice oral sex.

  20. HIV testing among patients infected with Neisseria gonorrhoeae: STD Surveillance Network, United States, 2009-2010. (United States)

    Bradley, Heather; Asbel, Lenore; Bernstein, Kyle; Mattson, Melanie; Pathela, Preeti; Mohamed, Mukhtar; Samuel, Michael C; Schwebke, Jane; Stenger, Mark; Tabidze, Irina; Zenilman, Jonathan; Dowell, Deborah; Weinstock, Hillard


    We used data from the STD Surveillance Network to estimate HIV testing among patients being tested or treated for gonorrhea. Of 1,845 gonorrhea-infected patients identified through nationally notifiable disease data, only 51% were tested for HIV when they were tested or treated for gonorrhea. Among the 10 geographic sites in this analysis, the percentage of patients tested for HIV ranged from 22-63% for men and 20-79% for women. Nearly 33% of the un-tested patients had never been previously HIV-tested. STD clinic patients were more likely to be HIV-tested than those in other practice settings.

  1. Acceptability and feasibility of using established geosocial and sexual networking mobile applications to promote HIV and STD testing among men who have sex with men. (United States)

    Sun, Christina J; Stowers, Jason; Miller, Cindy; Bachmann, Laura H; Rhodes, Scott D


    This study is the first published multi-app study, of which we are aware, to evaluate both the acceptability and feasibility of providing sexual health information and HIV/STD testing referrals via established geosocial and sexual networking apps for MSM. Data were collected using an online survey and through four apps (A4A Radar, Grindr, Jack'd, and Scruff). Two-thirds (64 %) found apps to be an acceptable source for sexual health information. MSM who found apps as acceptable were more likely non-white, not sure of their current HIV status, and have low HIV testing self-efficacy. One-quarter (26 %) of informational chats with the health educator resulted in users requesting and being referred to local HIV/STD testing sites. There were significant differences in the number and types of interactions across apps. Established apps designed for MSM may be both an acceptable and feasible platform to promote HIV/STD testing. Future research should evaluate interventions that leverage this technology.

  2. 78 FR 64221 - CDC/HRSA Advisory Committee on HIV, Viral Hepatitis and STD Prevention and Treatment; Notice of... (United States)


    ... Hepatitis and STD Prevention and Treatment; Notice of Meeting In accordance with section l0(a)(2) of the... meeting. Name: CDC/HRSA Advisory Committee on HIV, Viral Hepatitis and STD Prevention and Treatment Dates... related to prevention and control of HIV/AIDS, Viral Hepatitis and other STDs, the support of health care...

  3. Knowledge, Beliefs and Behaviours Related to STD Risk, Prevention, and Screening among a Sample of African American Men and Women (United States)

    Uhrig, Jennifer D.; Friedman, Allison; Poehlman, Jon; Scales, Monica; Forsythe, Ann


    Objective: Current data on sexually transmitted disease (STD) among African Americans show significant racial/ethnic disparities. The purpose of this study was to explore knowledge, attitudes, beliefs, and behaviours related to STD risk, prevention, and testing among African American adults to help inform the development of a health communication…

  4. 76 FR 38550 - Technical Standard DOE-STD-1095-2011, Department of Energy Laboratory Accreditation for External... (United States)


    ... CFR Part 835 Technical Standard DOE-STD-1095-2011, Department of Energy Laboratory Accreditation for...: Notification of updated Technical Standard. SUMMARY: The Department of Energy (DOE or the Department) is issuing Technical Standard DOE-STD-1095-2011, Department of Energy Laboratory Accreditation for External...

  5. Correlates of HIV/STD testing and willingness to test among rural-to-urban migrants in China. (United States)

    Wang, Bo; Li, Xiaoming; Stanton, Bonita; McGuire, James


    This study investigates socio-demographic, behavioral, psychological, and structural factors associated with self-reported HIV/STD testing and willingness to test among 1,938 Chinese migrants. Overall, 6% and 14% of participants had ever been tested for HIV and STD, respectively. The results of multivariate analyses indicate that working at entertainment sectors, engaging in commercial sex, and utilization of health care were positively associated with both HIV and STD testing. Younger age, selling blood, perceived peer sexual risk involvement, and satisfaction with life were associated with HIV testing only. Female gender, early sexual debut, multiple sexual partners, and perceived vulnerability to HIV/STD were associated with STD testing only. Male gender, having premarital sex, perceived higher severity of and vulnerability to HIV/STD, and utilization of health care were associated with willingness to be tested for both HIV and STD. Interventions designed to raise the perception of vulnerability to HIV/STD and to improve access to and utilization of health care may be effective in encouraging more HIV testing in this vulnerable population.

  6. The Determinants of Health Care Seeking Behaviour of Adolescents Attending STD Clinics in South Africa. (United States)

    Meyer-Weitz, Anna; Reddy, Priscilla; Van Den Borne, H. W.; Kok, Gerjo; Pietersen, P.


    Investigates the determinants of delay behavior in health care seeking in a sample of 292 adolescent patients with STD symptoms. Early health care seeking was determined by perceived seriousness of STDs, an absence of self treatment prior to seeking care, and positive attitudes regarding personal autonomy in condom use behavior. (Contains 17…

  7. Influence of Professional Preparation and Class Structure on HIV, STD, and Pregnancy Prevention Education (United States)

    Rhodes, Darson L.; Jozkowski, Kristen N.; Hammig, Bart J.; Ogletree, Roberta J.; Fogarty, Erin C.


    Objective: The purpose of this study was to determine if education about human immunodeficiency virus (HIV)/sexually transmitted disease (STD) and pregnancy prevention is dependent on professional preparation and/or class structure. Design: A secondary data analysis of the 2006 School Health Policies and Programmes Study (SHPPS) was conducted.…

  8. Depression, Suicidal Ideation and STD-Related Risk in Homeless Older Adolescents. (United States)

    Rohde, Paul; Noell, John; Ochs, Linda; Seeley, John R.


    Goals of this study were to examine the frequency of depression and related constructs of suicidal ideation and hopelessness in a sample of homeless older adolescents and their associations with behaviors, such as infrequent condom use and homosexual experience, that may increase the risk of sexually transmitted disease (STD). (BF)

  9. The effect of target's physical attractiveness and dominance on STD-risk perceptions

    NARCIS (Netherlands)

    Dijkstra, P; Buunk, BP; Blanton, H

    Utilizing a 2 x 2 design, the present study examined the effect of a female's physical attractiveness and dominance on men's sexual motivation and sexually transmitted disease (STD) risk perceptions in a sample of 72 heterosexual male college students. As predicted, participants a ere more motivated

  10. Factors Influencing Condom Use and STD Acquisition among African American College Women. (United States)

    Lewis, Lisa M.; Melton, Richard S.; Succop, Paul A.; Rosenthal, Susan L.


    Surveyed 123 sexually experienced African-American college women at a state university to identify factors influencing their condom use and the risk of acquiring sexually transmitted diseases (STDs). The women who were older, had initiated sex earlier, or had more recent sexual partners were more likely than others to report a history of an STD.…

  11. Sero-prevalence of hepatitis C virus amoung patients attending STD ...

    African Journals Online (AJOL)

    Since it has been established that sexual transmission is an important mode of acquisition of the infection, we therefore set out to find the seroprevalence of HCV among 95 patients attending sexually transmitted diseases (STD) clinic in University College Hospital, Ibadan, Nigeria with a view to recommending preventive ...

  12. New Caledonia: fatal intimacy: gender dynamics of STD and HIV / AIDS. (United States)

    Duituturaga, E


    This paper discusses the gender dynamics of sexually transmitted diseases (STDs) and HIV/AIDS based on the relationship between gender violence, reproductive health, sexuality, STD and HIV/AIDS. This approach highlights AIDS as an increasingly female concern, a consequence of the social makeup of female and male sexuality, and the result of inequalities that characterizes many heterosexual relationships. Gender violence is considered as the most intimate enemy among most women with an extremely high indirect cost to development. Not only that, it also causes more death and disability among women aged 14-44 years, having greater risk from their husbands, fathers, and neighbors or colleagues. Moreover, the link between gender violence and HIV/AIDS and STD can be observed through the rising incidence of these infections among women particularly during unprotected vaginal intercourse. Also, these women often bear the pain and discomfort associated with STD because of social constraints. The study calls for further research into behavior change interventions that address gender dynamics to prevent the fatal intimacy of women's vulnerability to STD and HIV, the intimate enemy of gender violence and the fatal encounter with AIDS. Lastly, the paper includes information about the work of the Pacific Women's Resource Bureau and its pioneering initiative on the Pacific multi-site study on violence against women.

  13. 75 FR 39264 - CDC/HRSA Advisory Committee on HIV and STD Prevention and Treatment (United States)


    ... CDC/HRSA Advisory Committee on HIV and STD Prevention and Treatment In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92-463), the CDC and HRSA announce the following..., CDC and the Administrator, HRSA, regarding activities related to prevention and control of HIV/AIDS...

  14. 77 FR 23733 - CDC/HRSA Advisory Committee on HIV and STD Prevention and Treatment (United States)


    ... CDC/HRSA Advisory Committee on HIV and STD Prevention and Treatment In accordance with section 10(a)(2... Prevention (CDC) and the Health Resources and Services ] Administration (HRSA) announce the following meeting... accommodate approximately 100 people. Purpose: This Committee is charged with advising the Director, CDC and...

  15. Comparison Evaluation of the PFP FSAR and NRC Regulatory Guide 3.39 with DOE-STD-3009-94

    Energy Technology Data Exchange (ETDEWEB)



    One of the Plutonium Finishing Plant's (PFP) current Authorization Basis (AB) documents is the Final Safety Analysis Report (FSAR). This FSAR (HNF-SD-CP-SAR-02 1) was prepared to the format and content guidance specified in U.S. Nuclear Regulatory Commission (NRC) Regulatory Guide 3.39, Standard Format and Content of License Applications for Plutonium Processing and Fuel Fabrication Plants (RG 3.39). In April 1992, the US Department of Energy (DOE) issued DOE Order 5480.23 which established the FSAR requirements for DOE nonreactor nuclear facilities. In 1994, DOE issued DOE-STD-3009-94, Preparation Guide for US. Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports, which is a format and content guide addressing the preparation of FSARs in accordance with DOE Order 5480.23. During the initial preparation and issuance of the PFP FSAR the format and content guidance contained in NRC Regulatory Guide 3.39 was utilized, since it was the most applicable guidance at the time for the preparation of Safety Analysis Reports for plutonium processing plants. With the adoption of DOE Order 5480.23 and DOE-STD-3009-94, DOE required the preparation of SARs to meet the format and content of those DOE documents. The PFP was granted an exemption to continue with RG 3.39 format for future FSAR revisions. PFP modifications and additions have required PFP FSAR modifications that have typically been prepared to the same NRC Regulatory Guide 3.39 format and content, to provide consistency with the PFP FSAR. This document provides a table comparison between the 3009 and RG 3.39 formats to validate the extent of PFP FSAR compliance with the intent of DOE Order 5480.23 and DOE-STD-3009-94. This evaluation was initially performed on Revisions 1 and 1A of the PFP FSAR. With the preparation of a Revision 2 draft to the FSAR, sections with significant changes were reevaluated for compliance and the tables were updated, as appropriate. The tables resulting from this

  16. DOE Handbook: Supplementary guidance and design experience for the fusion safety standards DOE-STD-6002-96 and DOE-STD-6003-96

    Energy Technology Data Exchange (ETDEWEB)



    Two standards have been developed that pertain to the safety of fusion facilities. These are DOE- STD-6002-96, Safety of Magnetic Fusion Facilities: Requirements, and DOE-STD-6003-96, Safety of Magnetic Fusion Facilities: Guidance. The first of these standards identifies requirements that subscribers to that standard must meet to achieve safety in fusion facilities. The second standard contains guidance to assist in meeting the requirements identified in the first This handbook provides additional documentation on good operations and design practices as well as lessons learned from the experiences of designers and operators of previous fusion facilities and related systems. It is intended to capture the experience gained in the various fields and pass it on to designers of future fusion facilities as a means of enhancing success and safety. The sections of this document are presented according to the physical location of the major systems of a fusion facility, beginning with the vacuum vessel and proceeding to those systems and components outside the vacuum vessel (the "Ex-vessel Systems"). The last section describes administrative procedures that cannot be localized to specific components. It has been tacitly assumed that the general structure of the fusion facilities addressed is that of a tokamak though the same principles would apply to other magnetic confinement options.

  17. Conducting Internet-based HIV/STD prevention survey research: considerations in design and evaluation. (United States)

    Pequegnat, Willo; Rosser, B R Simon; Bowen, Anne M; Bull, Sheana S; DiClemente, Ralph J; Bockting, Walter O; Elford, Jonathan; Fishbein, Martin; Gurak, Laura; Horvath, Keith; Konstan, Joseph; Noar, Seth M; Ross, Michael W; Sherr, Lorraine; Spiegel, David; Zimmerman, Rick


    The aim of this paper is to advance rigorous Internet-based HIV/STD Prevention quantitative research by providing guidance to fellow researchers, faculty supervising graduates, human subjects' committees, and review groups about some of the most common and challenging questions about Internet-based HIV prevention quantitative research. The authors represent several research groups who have gained experience conducting some of the first Internet-based HIV/STD prevention quantitative surveys in the US and elsewhere. Sixteen questions specific to Internet-based HIV prevention survey research are identified. To aid rigorous development and review of applications, these questions are organized around six common criteria used in federal review groups in the US: significance, innovation, approach (broken down further by research design, formative development, procedures, sampling considerations, and data collection); investigator, environment and human subjects' issues. Strategies promoting minority participant recruitment, minimizing attrition, validating participants, and compensating participants are discussed. Throughout, the implications on budget and realistic timetabling are identified.

  18. Patient, provider, and clinic characteristics associated with public STD clinic patient satisfaction (United States)

    Mehta, S; Zenilman, J; Erbelding, E


    Objectives: There is a lack of information describing levels of patient satisfaction among patients seeking sexually transmitted diseases (STD) care in a public clinic setting. We sought to identify patient, provider, and clinic characteristics associated with patient satisfaction within public STD clinics. Methods: A cross sectional survey with random sampling was conducted among patients attending two public STD clinics. Satisfaction was assessed using questions from validated national surveys. Outcomes for multivariate logistic regression analysis were ratings of overall health care and clinician. Results: 499/605 (82%) patients were enrolled. Patients were mean age 29 years, 51% male, 94% black. Lower rating of clinician technical skills (OR = 15.6 clinic A, OR = 7.9 clinic B) and clinic environment (OR = 3.9 clinic A, OR = 9.6 clinic B) were associated with lower healthcare rating, as was lower rating of television/video in waiting room (OR = 10.2, clinic A) and dysuria (OR = 4.2, clinic B). Higher clinician rating (OR = 0.58, clinic A) and receiving written materials (OR = 0.44, clinic B) were protective of lower healthcare rating. Risks for lower clinician rating at clinic A were greater pain, problems getting care, lower rating of clinician technical skill, and overall health care, while receiving written materials was protective. At clinic B, lower rating of clinician technical skill and clinic environment were risks for lower clinician rating. Conclusions: Patient satisfaction was associated with modifiable provider and clinic characteristics. Results from our study indicate a need to examine whether health outcomes of STD management vary by patient satisfaction. PMID:15800094

  19. Comparative parameters of fertility regulation as related to STD / HIV infections. An overview. (United States)

    Merino, G; Bailon, R; Correu, S


    The sexually transmitted disease (STD), chancroid, is the greatest factor for HIV infections in Africa like syphilis is in the US. 3 physicians suggest that reducing the incidence of STDs may reduce the spread of HIV. Risk factors for HIV include current or history of STD in women and bisexual men, pelvic inflammatory disease, semen, copper releasing IUDs, contraceptive dermatitis, malnutrition/food allergy, environmental pollutants, genetic make up, and prostitutes. HIV infected persons should use condoms to not only protect partners but to prevent repeated contact with HIV which influences the clinical outcome. Condom use for contraception is not widely practiced in some areas, however, including Central Africa and Haiti. Condom use has increased in the US because IUDs have been removed from the market, fear of HIV infection, and discontinued use of oral contraceptives in older women. Urticarial reactions secondary to a copper IUD often occur in adolescent women, but clears when the IUD is removed. Traces of nickel in the copper wire used in IUDs often induce an allergic reaction. Allergic reactions are cofactors of HIV which can be made worse if coupled with excessive menstrual bleeding and HIV infected semen cells entering the uterus via the IUD tail. Many countries have integrated family planning services with other public health services, such as STD clinics that address AIDS. Integrated services should provide STD services and contraception and involve males and be accessible to them. Comprehensive school based clinical model should be implemented into schools and colleges. Counselors should advice HIV infected women not to have any more children. These women should get top priority to family planning services. HIV antibody testing for women should be done at any center where women may be including family planning centers and prisons.

  20. Tailoring DOD-STD-2167A - A Survey of Current Usage (United States)


    are difficult to incorporate into established documentation processes and difficult to customise for specific developer requirements. (d) The tools are...tailoring will solve the problems of requirements expression and validation. Education of the users in the methods used for stating requirements was...establishment of tailoring guidelines tor DOD-STD-2167A projects in Australia. Current guidelines, tools and training courses, wXhile useful in educating

  1. [Integration of STD services. "All are part of the same service"]. (United States)

    Jana, S; Bailey, M


    Two projects have succeeded at integrating sexually transmitted disease (STD) services at the primary health care level. The first operates in Mwanza district in Tanzania. Nurses use the syndromic approach to diagnose STDs and prescribe treatment. They provide health education to STD patients while also distributing condoms and cards for partner contacts. Health workers attend a three-week seminar on diagnosing and treating the most common STDs. The first week is in a classroom. The remaining two weeks consist of practical training in a health center providing STD services. The project began at the main hospital in Mwanza and has since expanded to rural areas. Monthly supervisory visits to each health center ensure the drug supply. The project focuses on the symptoms of urethral infection, vaginal infection, and genital ulcers. Education programs and public awareness promote and popularize risk reduction sex behavior and improve utilization of health services. The other project (Sonagachi) serves sex workers and their clients in Calcutta, India. It integrates STD services with a primary health center. Since its inception in 1992, STDs have fallen and HIV prevalence has not changed. Sex workers involved in the Sonagachi project are more likely to use condoms with clients than those not involved in the project (50% vs. 20%). Community participation is the key to the success of the Sonagachi project. More than 65 former or current sex workers serve as peer educators. They have attended a six-week training program. They make home visits to sex workers to talk about sexual health, to distribute condoms, to show them how to use condoms, and to encourage them to attend the health center. Peer educators are proud of their work and say that their work gives them confidence and dignity. The peer educators with the most experience become peer educator trainers.

  2. STD control: a key issue for reproductive health. An interview with Professor David Mabey. (United States)


    Treatable bacterial sexually transmitted diseases (STDs) are disappearing in many parts of North America and northern Europe, where single-dose antibiotic treatments are available; however, in many parts of Africa and other parts of the developing world, STDs are among the leading health problems. 20% of adults attending government clinics seek treatment for a STD. Many patients go to private clinics, traditional practitioners, pharmacists, and quacks. Government facilities treat 1 million cases of STD a year in Zimbabwe (population, 10 million). Professor David Mabey of the London School of Hygiene and Tropical Medicine states that STDs are more common in developing countries because: 1) young adults who are most at risk form a greater proportion of the population; 2) urban drift and the large migratory labor force create and use prostitutes; and 3) treatment, if available, is unaffordable. Since the effect of health education and condom promotion is, to date, unclear, and diagnostic tests for STDs are often unfeasible in Africa, Mabey suggests using syndromic treatment, in which patients are treated for all the common causes of their collection of symptoms. Although some believe an infection can be diagnosed based on clinical evidence alone, Mabey states highly experienced clinicians have been shown to be correct only 70% of the time in their diagnosis of genital ulcers. A Tanzanian study has shown that the introduction of a syndromic treatment program using nurses and medical assistants reduced the rate of increase of human immunodeficiency virus (HIV) by 42%, in comparison to nearby communities where no new treatment program was introduced. Mabey stresses the importance of screening for syphilis in pregnancy and notification of partners. Pressure should be brought on national governments and international donors to subsidize STD treatment. Attendance at STD clinics previously fell when fees were introduced.

  3. Religious beliefs and HIV / AIDS / STD health promotion. (United States)

    Solomon, S


    Most people are raised in an environment that espouses a religion. Religions use different codes to structure people's lives. These codes contribute to the enforcement of societal discipline. Some religious laws bestow privileges to men (e.g., polygamy), which may make women more vulnerable to HIV/sexually transmitted diseases (STDs). These laws do not reflect the great changes in lifestyles. Communities still condemn people with HIV/AIDS as deserving the infection because they are immoral. Some community members, proclaiming religion as their justification, control the content of health education by limiting health education to sexual abstinence and fidelity. Should not religions also support the promotion of condom use? Everyone needs to learn about HIV/AIDS and to have access to preventive methods. Educators and counselors must avoid moralizing, but should instead offer people different options to protect themselves and others. Health educators should emphasize those religious codes and edicts with positive values relevant to the HIV/AIDS pandemic. No religious law calls for ostracizing individuals. Religious laws prohibit stigmatization, discrimination, prejudice, and ill-treatment. Religions tend to call for tolerance. They are founded on a universal belief of duty to support all suffering persons and to help them receive the best possible care and treatment. Thus, religion can help make HIV infection an acceptable social condition. On the grounds of edict or morality, religion cannot be a non-participant. In many cases, religion has restored respect, dignity, and understanding for persons with HIV/AIDS. Many religious groups provide care for such persons.

  4. NASA-STD-6001B Test 1 Upward Flame Propagation; Sample Length Impact on MOC Investigation (United States)

    Harper, Susana Tapia; Juarez, Alfredo; Woods, Brenton L.; Beeson, Harold D.


    Understanding the combustion behavior of materials in the elevated oxygen environments of habitable spacecraft is of utmost importance to crew safety and mission success. Currently, certification for unrestricted flight usage of a material with respect to flammability involves passing the Upward Flame Propagation Test of NASA-STD-6001B (Test 1). This test evaluates materials in a standardized test configuration for two failure criteria: self-extinguishment within 15 cm (6 in.) and the propensity of flame propagation by means of flaming material transfer. By the NASA standard, full-length samples are 30 cm (12 in.) in length; however, factors independent of the test method such as limited material availability or various nonstandard test configurations limit the full pretest sample lengths available for test. This paper characterizes the dependence, if any, of pretest sample length on NASA-STD-6001B Test 1 results. Testing was performed using the Maximum Oxygen Concentration (MOC) Threshold Method to obtain a data set for each sample length tested. In addition, various material types, including cloth (Nomex), foam (TA-301) and solids (Ultem), were tested to investigate potential effects of test specimen types. Though additional data needs to be generated to provide statistical confidence, preliminary findings are that use of variable sample lengths has minimal impact on NASA-STD-6001B flammability performance and MOC determination.

  5. Sexual Lifestyle, Risk Factors and Socioeconomic Status of the STD Patients in Bangladesh. (United States)

    Nandi, A K; Hossain, K J; Islam, A S


    Sexually transmitted diseases (STDs) are increasing alarmingly with time among the young-adults in Bangladesh. The objective of the study was to investigate Sexual lifestyle, Risk Factors and Socioeconomic Status of the STD Patients. A total of 205 STD patients were selected following convenient method of sampling consistent with defined selection criteria from outpatient department of Skin and Venereal Disease of Mymensingh Medical College Hospital, Mymensingh. Period of data collection was from July 2014 to June 2015. The research instrument was an interviewer questionnaire and laboratory investigation reports. Results showed that the mean age of the respondents was 27±5.9 years of which 104(50.7%) unmarried and 95(46.3%) married. Level of education, 168(82.0%) of the STD patients were literate. Occupation of the STD patients, 201(98.0%) had specific occupation of which 74(36.1%) were businessmen, 48(23.4%) student, 24(11.7%) technical jobs, 20(9.8%) day labourer, 15(7.3%) household workers, 14(6.8%) service holders and 6(2.9%) were transport workers. Their average monthly income was Tk. 7892±6763. Majority of the STD patients 115((56.1%) expressed that they enjoyed extra-marital sex or illegal sex out of curiosity, 32(15.6%) habitual, 24(11.7%) to test sexual performance, 18(8.8%) inadequate response of the legal sex partners, 8(3.9%) hyper-sexuality and 8(3.9%) family disharmony. Most of the patients 200(97.6%) were heterosexual of which 165(80.5%) visited 1-10 sex partners, 18(8.8%) 11-20 sex partners and 22(10.7%) visited 21-100 sex partners in lifetime. In category of sex partners, 60(29.3%) were hotel-based sex partners, 111(54.1%) brothel-based, 20(9.8%) friends sex partners, 10(4.9%) street sex sellers and 4(2.0%) were residential sex partners respectively. Of them, 132(64.4%) did not use condom during sex, 65(31.7%) use it occasionally and only 8(3.9%) use condom regularly. Most of them 170((82.8%) had been suffering from gonococcal urethritis, 19

  6. STD/HIV prevention in Turkey: planning a sequence of interventions. (United States)

    Aral, S O; Fransen, L


    This study was initiated to assess which mix of early STD/HIV prevention interventions would potentially be effective, cost-effective and sustainable in Turkey; and to program an intervention sequence to maximize synergy among the interventions. During rapid assessment we: 1) reviewed past issues of 3 leading newspapers; 2) collected information on TV coverage; 3) interviewed key informants including taxicab drivers, hotel employees, grocery store owners, academicians in public health and law, investigators of STD/HIV and reproductive tract infections, and officials in the ministry of health; 4) reviewed available evidence on STD/HIV morbidity, sexual behavior patterns, migration patterns and same/opposite gender sex trade. We found: 1) discrepancies between decision makers' perceptions and social realities with respect to the epidemiology of sexual behavior and STDs, and the state of public health programs; 2) discrepancies between sexual practices and public expression regarding sexual practices; 3) economic, demographic, and political pressures in Turkey and in surrounding countries for the expansion of prostitution; 4) a sexual double standard and gender specific migration patterns which sustain a high demand for commercial sex; 5) patterns of health care seeking behaviors and provision of STD clinical services which indicate other STDs may play a very important role in spread of HIV infection; 6) an important mass media role in opinion formation; 7) consensual denial of risk for the majority based on beliefs embedded in machismo, nationalism and religion, and a resulting marginalization and externalization of STD/HIV risk; 8) high prevalence of syphilis among both Turkish and immigrant female prostitutes in Istanbul (early latent 8 and 13%; late latent 0 and 4%; previous history 9 and 22%) 9) and high rates of syphilis among male prostitutes (early latent 11%, late latent 21% and previous history 58%). We concluded that interventions should initially include

  7. State laws related to billing third parties for healthcare services at public STD clinics in the United States. (United States)

    Cramer, Ryan; Loosier, Penny S; Krasner, Andee; Kawatu, Jennifer


    Health departments (HDs) cite state laws as barriers to billing third parties for sexually transmitted disease (STD) services, but the association between legal/policy barriers and third party HD billing has not been examined. This study investigates the relationship between laws that may limit HDs' ability to bill, clinic perceptions of billing barriers, and billing practices. Two surveys (1) clinic managers [N=246], 2) STD program managers [N=63]) conducted via a multi-regional needs assessment of federally funded HD clinics' capacity to bill for STD services, billing/reimbursement practices, and perceived barriers were combined with an analysis of state laws regarding third party billing for STD services. Statistical analyses examined relationships between laws that may limit HDs' ability to bill, clinic perceptions, and billing practices. Clinic managers reported clinics were less likely to bill Medicaid and other third parties in jurisdictions with a state law limiting their ability to bill compared to respondents who billed neither or one payer (OR=0.31, CI=0.10,0.97) and cited practical concerns as a primary barrier to billing (OR=2.83 CI=1.50,5.37). STD program managers' reports that staff believed STD services should be free (OR=0.34, CI=0.13, 0.90) was associated with not billing (not sure versus no resistance to billing); confidentiality concerns was not a reported barrier to billing among either sample. Practical concerns and clinic staff beliefs that STD services should be free emerged as possible barriers to billing, and laws less so. Attempts to initiate HD billing for STD services may benefit from staff education as well as addressing perceived legal barriers and staff concerns.

  8. HIV, other STD, and pregnancy prevention education in public secondary schools -- 45 states, 2008-2010. (United States)


    In the United States, 46% of high school students have had sexual intercourse and potentially are at risk for human immunodeficiency virus (HIV) infection, other sexually transmitted diseases (STDs), and pregnancy. The National HIV/AIDS Strategy for the United States recommends educating young persons about HIV before they begin engaging in behaviors that place them at risk for HIV infection. The Community Preventive Services Task Force (CPSTF) also recommends risk reduction interventions to prevent HIV, other STDs, and pregnancy among adolescents. To estimate changes in the percentage of secondary schools that teach specific HIV, other STD, and pregnancy risk reduction topics, a key intervention consistent with those supported by the National HIV/AIDS Strategy and CPSTF, CDC analyzed 2008 and 2010 School Health Profiles data for public secondary schools in 45 states. This report summarizes the results of those analyses, which indicated that in 2010, compared with 2008, the percentage of secondary schools teaching 11 topics on HIV, other STD, and pregnancy prevention in a required course in grades 6, 7, or 8 was significantly lower in 11 states and significantly higher in none; the percentage of secondary schools teaching eight topics in a required course in grades 9, 10, 11, or 12 was significantly lower in one state and significantly higher in two states; and the percentage of secondary schools teaching three condom-related topics in a required course in grades 9, 10, 11, or 12 was significantly lower in eight states and significantly higher in three states. Secondary schools can increase efforts to teach all age-appropriate HIV, other STD, and pregnancy prevention topics to help reduce risk behaviors among students.

  9. Prevalence and Genotype Distribution of Chlamydia trachomatis in Urine among Men Attending STD Clinics in Guangdong Province, China, 2016. (United States)

    Xue, Yaohua; Zheng, Heping; Tang, Weiming; Mai, Zhida; Huang, Jinmei; Huang, Shujie; Qin, Xiaolin; Chen, Lei; Zheng, Lei


    Studies rarely assessed the genotype distribution of chlamydia trachomatis (CT) in urine among men attending STD clinics (MSCs) in China. This study aimed to investigate the prevalence and molecular epidemiology of CT infection by examining urine samples among MSCs from different geographic areas of Guangdong province, China. A cross-sectional study was conducted among MSCs from ten HIV sentinel surveillance sites in Guangdong province. CT DNA in men urine samples were extracted and detected by using the Roche cobas® 4800 CT/NG. The ompA genes were amplified by nested polymerase chain reaction (PCR) and sequenced. The leukocyte esterase test was performed by routine urine analysis at local clinics. Of the 1903 samples, 163(8.6%, 95%CI3.8- 16.3%) were found to be positive for CT. The highest prevalence (10.5%) of CT infection was observed among participants aged 21-30. One hundred and thirty CT positive specimens (79.8%, 130/163) were successfully genotyped by nested PCR, resulting in eight genotypes. The most prevalent genotypes were D, E, F, and J, with proportions of 20.8%, 20.0%, 17.7%, and 16.9%, respectively. There was no significant difference in geographic area, leukocyte esterase test and genotype distribution. Promotion of detection and molecular epidemiology research is needed for effective and comprehensive prevention and control programs.

  10. The proposal of permanent education in the formation of dentists in std/hiv/aids

    Directory of Open Access Journals (Sweden)

    Maria de Fátima Nunes


    Full Text Available The objective of this work is to report the experience of the "Project for the formation of dentists as facilitators of Permanent Education in Health in the area of STD/HIV/AIDS" developed in partnerships with the National Program of STD/AIDS, the Technical Area of Oral Health of the Ministry of Health, Public Universities and Municipal and State Secretaries of Health. The objective of the program was to capacitate dentists of the public health system in Brazilian states and cities to provide integral and humanized attendance for people living with HIV/AIDS. The methodology of choice for the form of teams of facilitators was Permanent Education in Health through semi-presential courses focusing on the problematization of local and professional realities. Thus, seeking to construct a process of education to modify and reorient the hegemonic dental practice, strengthening the process of attendance and management and the partnerships, guaranteeing the sustainability of the actions in the states and cities.

  11. Probing a CMP-Kdn synthetase by 1H, 31P, and STD NMR spectroscopy. (United States)

    Haselhorst, Thomas; Münster-Kühnel, Anja K; Stolz, Anita; Oschlies, Melanie; Tiralongo, Joe; Kitajima, Ken; Gerardy-Schahn, Rita; von Itzstein, Mark


    CMP-Kdn synthetase catalyses the reaction of sialic acids (Sia) and cytidine-5'-triphosphate (CTP) to the corresponding activated sugar nucleotide CMP-Sia and pyrophosphate PP(i). STD NMR experiments of a recombinant nucleotide cytidine-5'-monophosphate-3-deoxy-d-glycero-d-galacto-nonulosonic acid synthetase (CMP-Kdn synthetase) were performed to map the binding epitope of the substrate CTP and the product CMP-Neu5Ac. The STD NMR analysis clearly shows that the anomeric proton of the ribose moiety of both investigated compounds is in close proximity to the protein surface and is likely to play a key role in the binding process. The relative rates of the enzyme reaction, derived from (1)H NMR signal integrals, show that Kdn is activated at a rate 2.5 and 3.1 faster than Neu5Ac and Neu5Gc, respectively. Furthermore, proton-decoupled (31)P NMR spectroscopy was successfully used to follow the enzyme reaction and clearly confirmed the appearance of CMP-Sia and the inorganic pyrophosphate by-product.

  12. Current socioclinical trend of sexually transmitted diseases and relevance of STD clinic: A comparative study from referral tertiary care center of Gwalior, India

    Directory of Open Access Journals (Sweden)

    Sandeep Singh


    Full Text Available Objective: Sexually transmitted infections (STIs are the major public health concern in both developed and developing countries regulated by the cultural pattern of gender expression in their society. Thus, it demanded a necessary action to review the changing pattern in (Gwalior, central India where health condition is not in a good fashion with poor socioeconomic status and awareness. Materials and Methods: This is a hospital based cross sectional questionnaire study with a sample size of 222 respondents attending sexually transmitted disease (STD clinic at JAH Gwalior from December 2011 to March 2012 using a random sampling method. Results: Most of the cases among females were in the age group of 20-40 years (152, 84.44% and males were in 18-40 years age group (35, 83.33%. Out of 180, 22 (12.22% females were having non-regular sexual partners. Out of 22 females frequency of consistent, non-consistent, and no condom use with non-regular sexual partners was three (13.63%, two (9.09%, and 17 (77.27%, respectively. Out of 42 males, 22 (52.38% reported having sex with non-regular sexual partners. None of the 15 (100% male subjects having friends or relatives as non-regular sexual partner were using condoms. Statistically significant differences were found as compared to a previous study from same STD clinic are discharge, lower abdominal pain, painful micturition, nodules in genitals as 106 (58.88%; P = 0.0001, 59 (32.77%; P = 0.0007, 25 (13.88%; P = 0.001, and one (0.5%; P = 0.005, respectively and in males with absence of abdominal pain and nodules in genitals as P = 0.016 and 0.03, respectively. Preferred place of treatment of STIs was government facility in both male and females with statistically significant 15.76% (P = 0.0001 of the population seeking no treatment. Discussions: Study suggests a changing trend of the STDs owing to the difference in the clinical presentation of the disease to a previous study from the same STD clinic few years

  13. Evaluation of a Statewide HIV-HCV-STD Online Clinical Education Program by Healthcare Providers - A Comparison of Nursing and Other Disciplines. (United States)

    Wang, Dongwen; Luque, Amneris E


    The New York State HIV-HCV-STD Clinical Education Initiative (CEI) has developed a large repository of online resources and disseminated them to a wide range of healthcare providers. To evaluate the CEI online education program and in particular to compare the self-reported measures by clinicians from different disciplines, we analyzed the data from 1,558 course completions in a study period of three months. The results have shown that the overall evaluations by the clinicians were very positive. Meanwhile, there were significant differences across the clinical disciplines. In particular, physicians and nurse practitioners were the most satisfied. In contrast, pharmacists and case/care managers recorded lower than average responses. Nurses and counselors had mixed results. Nurse practitioners' responses were very similar to physicians on most measures, but significantly different from nurses in many aspects. For more effective knowledge dissemination, online education programs should consider the unique needs by clinicians from specific disciplines.

  14. Ethical issues in the NIMH Collaborative HIV/STD Prevention Trial. (United States)


    To develop decision rules regarding key ethical dimensions in scientific protocols for the National Institute for Mental Health (NIMH) Collaborative HIV/STD Prevention Trial taking place in five countries (China, India, Peru, Russia, and Zimbabwe). Countries had HIV rates from 27 to 0.1%, the standard of care varied from access to antiretroviral drugs to no availability, and the reporting of sexually transmitted diseases (STD) to government agencies was mandatory in some countries and not in others. These variations presented challenges when developing decision rules that could be uniformly adopted across countries and simultaneously follow the ethical principles of beneficence, respect, and justice. We used several strategies to identify and resolve ethical dilemmas for this international HIV prevention trial. First, we identified key principles, especially those derived for clinical therapeutic, biomedical preventive, or device trials. We convened a 'workgroup on protecting human participants' and charged them with identifying and implementing optimal procedures for ensuring the ethical and equitable treatment of participants and making recommendations to minimize physical, psychological, and social harm to the participants. Each site had a community advisory board, essential in identifying local ethical issues and possible resolutions to them. The NIMH established a data safety and monitoring board with ultimate responsibility for adjudicating ethical dilemmas and decisions. The protocols were deliberated thoroughly by the Trial steering committee, and approved by nine United States and five in-country institutional review boards. We summarize the decision rules adopted to resolve the ethical dilemmas identified. Especially important were the translation of clinical trials principles for a behavioral intervention trial, strategies for ensuring confidentiality and informed consent, dilemmas relating to partner notification of sexually transmitted infections

  15. Sociological and psychological predictors of STD infection in homosexual men: a study of four countries. (United States)

    Ross, M W


    I investigated over 600 homosexual men in four countries (Sweden, Finland, Ireland, and Australia) regarding the number of times they had contracted a sexually transmitted disease (STD) and several psychological variables including masculinity and feminity, sex role conservatism, relationships with parents, number of sexual partners, attitudes towards homosexuality, and involvement in the homosexual subculture. Using multiple linear regression in each country, it was found that 19-42% of the variance of number of times infected could be accounted for by psychosocial factors, seven of which were common to all countries. The number of sexual partners was not a significant variable in any country. These data strongly suggest that numbers of infections in homosexual men are best predicted by psychological factors, and this has considerable implications for preventative and treatment programmes for homosexuals.

  16. UNDP supports HIV / AIDS / STD project for war-torn south Sudan -- a special report. (United States)

    Del Viso, N


    This article describes a UN HIV/AIDS and sexually transmitted disease (STD) project in war-torn south Sudan. The 3-year project relies on collaboration between adversaries and implementation in government-held and rebel-controlled areas. The project aims to reduce the risk and vulnerability to HIV/AIDS/STDs and to foster dialogue among adversaries as a means of conflict resolution. The World Health Organization will contribute technical assistance. Local partners including the government, the Southern Sudan Independence Movement, and the Sudanese People's Liberation Movement will contribute resources valued at about $100,000. The total UN contribution is about $300,000. HIV transmission has increased due to a high concentration of military personnel and population displacement. Available information suggests that the south has the highest HIV prevalence and 46% of known AIDS cases. STDs increased from 2.3% in 1989 to 14.1% in 1994. The project focuses on women, youth, and other vulnerable groups. The project is in its 9-month preparatory phase. The preparatory phase includes analysis of the HIV/AIDS/STD situation, design of a sustainable program, assessment of causative factors, and establishment of a mechanism for effectively coordinating the project. The civil war will affect priorities, strategies, and activities. In government-controlled areas, the Sudan National AIDS program will conduct activities. In non-government areas, the Sudan Rehabilitation and Relief Association, the Relief Association for South Sudan, and health and humanitarian authorities of the liberation groups will conduct programs. The UN Office of Special Projects will provide oversight during the preparatory phase. Sudan's UN Country Theme Group on HIV/AIDS will be the coordinating group.

  17. Validity of self-reported sexually transmitted diseases among African American female adolescents participating in an HIV/STD prevention intervention trial. (United States)

    Harrington, K F; DiClemente, R J; Wingood, G M; Crosby, R A; Person, S; Oh, M K; Hook, E W


    Studies assessing the validity attributed to self-reported measures of sexually transmitted diseases (STDs) clearly are needed, particularly those used for high-risk populations such as female adolescents, in whom STD prevention is a priority. To determine the accuracy of self-reported STD test results in female adolescents over a relatively brief period ( approximately 28 days). A prospective, randomized, controlled clinical trial of STD/HIV prevention for African American females, ages 14 to 18, was conducted. Study participants were recruited from medical clinics and school health classes in low-income neighborhoods of Birmingham, Alabama, that had high rates of unemployment, substance abuse, violence, STDs, and teenage pregnancy. Of the 522 adolescents enrolled in the trial, 92% (n = 479) completed baseline STD testing and follow-up surveys. At baseline, 28% had positive test results for at least one disease: 4.8% for Neisseria gonorrhoeae, 17.1% for Chlamydia trachomatis, and 12.3% for Trichomonas vaginalis. Of the adolescents with negative STD test results, 98.8% were accurate in their self-report of STD status, as compared with 68.7% of the adolescents with positive results. Underreporting varied by type of STD. Adolescents who accurately reported their positive STD status were significantly more likely to report their receipt of treatment accurately (P false conclusions regarding the efficacy of prevention interventions. This observation highlights the importance of using biologic indicators as outcome measures.

  18. 77 FR 66469 - CDC/HRSA Advisory Committee on HIV, Viral Hepatitis and STD Prevention and Treatment (United States)


    ... the public about HIV/AIDS and other STDs. Matters To Be Discussed: Agenda items include: (1) Treatment Cascade--Linkage to Care/Retention in Care--Treatment as Prevention; (2) Ryan White HIV/AIDS Program... Hepatitis and STD Prevention and Treatment In accordance with section 10(a)(2) of the Federal Advisory...

  19. 78 FR 32392 - CDC/HRSA Advisory Committee on HIV, Viral Hepatitis and STD Prevention and Treatment (United States)


    ... CDC/HRSA Advisory Committee on HIV, Viral Hepatitis and STD Prevention and Treatment In accordance... Administrator, HRSA, regarding activities related to prevention and control of HIV/AIDS, Viral Hepatitis and... professionals and the public about HIV/AIDS, Viral Hepatitis and other STDs. Matters To Be Discussed: Agenda...

  20. Short-Term Impact of Safer Choices: A Multicomponent, School-Based HIV, Other STD, and Pregnancy Prevention Program. (United States)

    Coyle, Karin; Basen-Engquist, Karen; Kirby, Douglas; Parcel, Guy; Banspach, Stephen; Harrist, Ronald; Baumler, Elizabeth; Weil, Marsha


    Evaluated the effectiveness of the first year of "Safer Choices," a two-year, multicomponent HIV, STD, and pregnancy-prevention program for high school students based on social theory. Student self-report surveys indicated that "Safer Choices" succeeded in reducing selected risk behaviors and in enhancing selected protective…

  1. 75 FR 22145 - Health Resources and Services Administration (HRSA); CDC/HRSA Advisory Committee on HIV and STD... (United States)


    ... expedited partner therapy implementation; (4) an update from the CHACHSPT Workgroup on HIV Care, Treatment... (HRSA); CDC/HRSA Advisory Committee on HIV and STD Prevention and Treatment (CHACHSPT) In accordance... the Administrator, HRSA, regarding activities related to the prevention and control of HIV/AIDS and...

  2. 75 FR 63844 - Health Resources and Services Administration CDC/HRSA Advisory Committee on HIV and STD... (United States)


    ... CDC/HRSA Advisory Committee on HIV and STD Prevention and Treatment (CHACHSPT) In accordance with... the National HIV/AIDS Strategy; (2) CHACHSPT Realignment Program Review Workgroup update; (3) update..., older persons, and other patients determined to be at low risk; and (4) updates on HIV prevention...

  3. Sexual Sensation Seeking, Social Stress, and Coping Styles as Predictors of HIV/STD Risk Behaviors in Adolescents (United States)

    Teva, Inmaculada; Bermudez, Maria Paz; Buela-Casal, Gualberto


    The aim of this study was to assess whether coping styles, social stress, and sexual sensation seeking were predictors of HIV/STD risk behaviours in adolescents. A representative sample of 4,456 female and male Spanish high school students aged 13 to 18 years participated. A stratified random sampling procedure was used. Self-report questionnaires…

  4. Real-life IT architecture design reports and their relation to IEEE Std 1471 stakeholders and concerns

    NARCIS (Netherlands)

    van Vliet, H.; Koning, H.


    Architectural designs are an important means to manage the development and deployment of information technology (IT). Much debate has been going on about a proper definition of architecture in IT and about how to describe it. In 2000, the IEEE Std 1471 proposed a model of an architecture description

  5. Male to female and female to male transgender persons have different sexual risk behaviors yet similar rates of STDs and HIV. (United States)

    Stephens, Sally C; Bernstein, Kyle T; Philip, Susan S


    The epidemiology of STDs and HIV among male-to-female (MTF) and female-to-male (FTM) transgender persons is limited, which makes prevention for transgender populations challenging. We examined data collected at visits for all self-identified MTF and FTM patients at the municipal STD clinic in San Francisco from January 1, 2006 to December 31, 2009. We compared demographic and socio-behavioral characteristics, as well as STD and HIV positivity and history of previous STD. Despite demographic and behavioral risk differences, there were no differences in STD positivity or HIV prevalence between MTF and FTM. A more complete understanding of the prevention needs for transgender persons is needed.

  6. Quantification of Soil Physical Properties by Using X-Ray Computerized Tomography (CT) and Standard Laboratory (STD) Methods

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez, Maria Ambert [Iowa State Univ., Ames, IA (United States)


    The implementation of x-ray computerized tomography (CT) on agricultural soils has been used in this research to quantify soil physical properties to be compared with standard laboratory (STD) methods. The overall research objective was to more accurately quantify soil physical properties for long-term management systems. Two field studies were conducted at Iowa State University's Northeast Research and Demonstration Farm near Nashua, IA using two different soil management strategies. The first field study was conducted in 1999 using continuous corn crop rotation for soil under chisel plow with no-till treatments. The second study was conducted in 2001 and on soybean crop rotation for the same soil but under chisel plow and no-till practices with wheel track and no-wheel track compaction treatments induced by a tractor-manure wagon. In addition, saturated hydraulic (K{sub s}) conductivity and the convection-dispersion (CDE) model were also applied using long-term soil management systems only during 2001. The results obtained for the 1999 field study revealed no significant differences between treatments and laboratory methods, but significant differences were found at deeper depths of the soil column for tillage treatments. The results for standard laboratory procedure versus CT method showed significant differences at deeper depths for the chisel plow treatment and at the second lower depth for no-till treatment for both laboratory methods. The macroporosity distribution experiment showed significant differences at the two lower depths between tillage practices. Bulk density and percent porosity had significant differences at the two lower depths of the soil column. The results obtained for the 2001 field study showed no significant differences between tillage practices and compaction practices for both laboratory methods, but significant differences between tillage practices with wheel track and no-wheel compaction treatments were found along the soil

  7. Women's experiences with anal sex: motivations and implications for STD prevention. (United States)

    Maynard, Emily; Carballo-Diéguez, Alex; Ventuneac, Ana; Exner, Theresa; Mayer, Kenneth


    Heterosexual anal intercourse is a highly efficient mode of HIV transmission, yet little is known about the contexts in which women engage in it, or when and with whom they use condoms. Similarly, sexuality and reproductive health research has paid little attention to female desire and pleasure-seeking. In-depth interviews were conducted in Boston in 2006 with 28 women who reported having had unprotected anal intercourse in the last year with a man who was HIV-positive or whose serostatus was unknown. Sexual scripting theory guided analyses of their experiences with and motivations to practice anal intercourse. Participants engaged in anal intercourse for a wide variety of reasons: to experience physical pleasure, enhance emotional intimacy, please their male partners or avoid violence. Male partners usually initiated anal sex. Anal intercourse often occurred in the context of vaginal and oral sex. Among reasons women cited for not using condoms were familiarity with their partner and feeling that condoms made anal sex less pleasurable. Knowledge of HIV and STD risks did not appear to encourage condom use. Women who perceive condom use during anal sex as limiting their pleasure or intimacy may be at increased risk for acquiring HIV. Consequently, interventions to promote safer anal intercourse must find a way to increase the use of barrier methods without decreasing pleasure or perceived intimacy between sexual partners.

  8. Over Batch Analysis for the LLNL DOE-STD-3013 Packaging System

    Energy Technology Data Exchange (ETDEWEB)

    Riley, D C; Dodson, K


    This document addresses the concern raised in the Savannah River Site (SRS) Acceptance Criteria about receiving an item that is over batched by 1.0 kg of fissile materials. This document shows that the occurrence of this is incredible. Some of the Department of Energy Standard 3013 (DOE-STD-3013) requirements are described in Section 2.1. The SRS requirement is discussed in Section 2.2. Section 2.3 describes the way fissile materials are handled in the Lawrence Livermore National Laboratory (LLNL) Plutonium Facility (B332). Based on the material handling discussed in Section 2.3, there are only three errors that could result in a shipping container being over batched. These are: incorrect measurement of the item, selecting the wrong item to package, and packaging two items into a single shipping container. The analysis in Section 3 shows that the first two events are incredible because of the controls that exist at LLNL. The third event is physically impossible. Therefore, it is incredible for an item to be shipped to SRS that is more than 1.0 kg of fissile materials over batched.

  9. STD Clinic Patients' Awareness of Non-AIDS Complications of HIV Infection. (United States)

    Castro, José Guillermo; Granovsky, Inna; Jones, Deborah; Weiss, Stephen M


    Participants were recruited from a sexually transmitted disease (STD) clinic in Florida and were assessed regarding the knowledge and awareness of non-AIDS conditions associated with HIV infection. Questionnaires were administered before and after a brief information session on non-AIDS conditions associated with HIV infection. Participants included men (n = 46) and women (n = 51). Prior to the information session, at baseline, only 34% of the participants were worried about HIV infection. Most participants (82%) agreed that HIV could be treated with antiretroviral therapy (ART), while only 38% were aware that HIV-associated conditions cannot be easily treated with ART. After the information session, almost all participants reported they were concerned regarding the risk of HIV infection. High-risk patients may have limited knowledge about the consequences of HIV infection beyond the traditional AIDS-associated conditions. Increased awareness of these less known consequences of HIV infection may decrease the potential for complacency regarding acquiring HIV infection. © The Author(s) 2014.

  10. An evaluation of peer-led STD/HIV prevention work in a public sex environment. (United States)

    French, R; Power, R; Mitchell, S


    This paper describes an independent evaluation of a peer-led STD/HIV prevention intervention conducted by Gay Men Fighting AIDS (GMFA) in a public sex environment (PSE). A variety of quantitative and qualitative research methods were employed to collect data on the intervention process as well as its outcomes. The main aim of the intervention was the distribution of condoms and safer sex literature to PSE users. During a five-month period, over 100,000 condoms and 2,200 safer sex information packs were distributed by GMFA volunteers to the PSE users. Condom provision was identified as the most needed health promotion activity in PSEs in a survey of gay and bisexual men (n = 688) conducted by the evaluators. Data collected showed that condoms provided by GMFA, as well as from other sources, were being used in the PSE. The peer-led focus of the intervention was acceptable to the PSE users. In addition, high levels of commitment and input from the volunteers contributed considerable added value to the intervention. The evaluation found that GMFA was successful in reaching the target population and addressing their needs and demands.

  11. Comprehensive STD/HIV prevention education targeting US adolescents: review of an ethical dilemma and proposed ethical framework. (United States)

    Brown, E J; Simpson, E M


    Adolescents are increasingly at risk for sexually transmitted diseases (STDs), including human immunodeficiency virus (HIV) infection. The prolonged latency period, sometimes in excess of five years, and the incubation period of up to 10 years before the manifestation of symptoms, may foster adolescents' false sense of invincibility and denial as they often do not see the devastating effects of the disease in their peers until they are older. In turn, their practice of safer sex may be hindered and thereby contribute to the escalation of this public health crisis among sexually active adolescents. Prevention-focused recommendations were made in the USA as a result of this crisis. Recommendations were made to: (1) include STD/HIV education in the curricula of grades kindergarten to 12; (2) increase to at least 75% the proportion of primary care and mental health professionals who provide age-appropriate STD/HIV prevention counselling to adolescents; and (3) expand HIV prevention services to include age-appropriate HIV education curricula for students in grades 4-12 in 95% of schools. Yet, in the USA, the provision of school-based comprehensive STD/HIV education has been difficult to achieve owing to certain limitations and, in some instances, legal action. These limitations include: limited student access; restricted content; and the implementation of sporadic and/or brief educational programmes. Given these recommendations and the fact that adolescents are acquiring STDs and HIV infections at increasing rates, and despite the limitations and legal actions, do health care professionals not have an ethical obligation to provide adolescents with comprehensive STD/HIV prevention education? This ethical dilemma will be discussed using the ethical decision-making principles of 'autonomy' and 'beneficence', and a decision-making model proposed by Thompson and Thompson, and by Chally and Loric.

  12. IEEE Std 730 Software Quality Assurance: Supporting CMMI-DEV v1.3, Product and Process Quality Assurance (United States)


    Architecture and Framework – CMMI ® for Acquisition, ACQ • 22 process areas – include process & product quality assurance, PPQA – CMMI ® for Services, SVC ...2011 Walz IEEE Std 730 Software Quality Assurance: Supporting CMMI -DEV v1.3, Product and Process Quality Assurance 1 John Walz 2012 President...Quality Assurance: Supporting CMMI -DEV v1.3, Product and Process Quality Assurance 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6

  13. MIL-STD-398 Acceptance Test of Ammunition Peculiar Equipment (APE) 1974E002 Continuity Kit for M76 Grenade (United States)


    1974E002 Continuity Kit For M76 Grenade to MIL-STD-398. Military Standard Shields, Operational for Ammunition Operations, Criteria for Design of and... Grenade , Launcher, Smoke, IR Screening, M76 is functioned in the APE 1974E002. Functioning of this device is for test purposes only and not part of...normal operations for continuity testing the grenade . Thermal flux or blast overpressure amplitudes were too low to record. It is recommended that this

  14. Masculinity, vulnerability and prevention of STD/HIV/AIDS among male adolescents: social representations in a land reform settlement

    Directory of Open Access Journals (Sweden)

    Camila de Oliveira Arraes


    Full Text Available OBJECTIVE: to analyze the relationship of masculinity, vulnerability and prevention of STD / HIV / AIDS among adolescent males of a land reform settlement in central Brazil. METHOD: a qualitative study using as precepts the strands of social representations with teenagers between 12 to 24 years. RESULTS: three categories emerged - Perception of vulnerability; Gender and vulnerability; and, Prevention and vulnerability to STD / HIV / AIDS. Adolescents felt invulnerable to sexually transmitted diseases anchored in the social representations in favor of the male hegemony. An ignorance about forms of prevention for STD / HIV / AIDS was demonstrated in their statements. It is believed that institutional projects such as the School Health Program and the Men's Health Care Program constitute essential tools to minimize factors of vulnerability in this population, since the school is recognized as a social facility that promotes socialization of experiences and contributes to the construction of the identity of the adolescent. CONCLUSION: the social representations of masculinity collaborate for the vulnerable behavior of the adolescents for the acquisition of sexually transmitted diseases. One hopes that this study can contribute to the production of knowledge and technical-scientific improvement of the professionals, especially the nurse, in order to discuss issues related to male sexuality of adolescents in the situation of the land reform settlement.

  15. Using community-based participatory research to develop an intervention to reduce HIV and STD infections among Latino men. (United States)

    Rhodes, Scott D; Hergenrather, Kenneth C; Montaño, Jaime; Remnitz, Ivan M; Arceo, Ramiro; Bloom, Fred R; Leichliter, Jami S; Bowden, W Patrick


    Although the Latino community living in the United States has been disproportionately affected by the intersecting epidemics of HIV and sexually transmitted diseases (STDs), the development, implementation, and evaluation of HIV and STD prevention interventions designed to reduce infection among Latinos lags behind prevention efforts targeting other communities. HoMBReS: Hombres Manteniendo Bienestar y Relaciones Saludables is a sexual risk reduction intervention designed to reduce HIV and STD infection among recently arrived, non-English-speaking Latino men who are members of a multicounty Latino soccer league in central North Carolina, a region of the United States with both the fastest growing Latino population and disproportionate HIV and STD infection rates. HoMBReS was developed in partnership with the local Latino community using community-based participatory research (CBPR). We describe (a) the CBPR partnership history and further expansion; (b) the development of the intervention through the integration of collected formative data, theoretical considerations, and findings from the scientific literature; and (c) lessons learned while using a CBPR approach to develop HoMBReS.

  16. Indentifying the Root Causes of Health Inequities: Reflections on the 2011 National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention Health Equity Symposium

    National Research Council Canada - National Science Library

    Ana Penman-Aguilar; Kathleen McDavid Harrison; Hazel D Dean


      In August 2011, the Centers for Disease Control and Prevention's (CDC's) National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention held a one-day health equity symposium titled "Identifying Root Causes of Health Inequities...

  17. Water physics and chemistry data from STD casts from THELMA DALE II and other platforms from 09 August 1954 to 05 March 1959 (NODC Accession 7101380) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Water physics and chemistry data were collected from STD casts from THELMA DALE II and other platforms from 09 August 1954 to 05 March 1959. Data were submitted by...

  18. Can variation in HIV/STD-related risk be explained by individual SES? Findings from female sex workers in a rural Chinese county


    Fang, Xiaoyi; Li, Xiaoming; Yang, Hongmei; Hong, Yan; Stanton, Bonita; ZHAO, RAN; Dong, Baiqing; Liu, Wei; Zhou, Yuejiao; Liang, Shaoling


    Low socioeconomic status (SES) has been linked to HIV and sexually transmitted disease (STD) at a macro level because the majority of new cases of HIV infection in the world have been reported in underdeveloped or developing countries. However, empirical data on the relationship between individual SES and HIV/STD related risk have been mixed. Employing quantitative data from 454 female sex workers, this study was designed to examine the profile of the study sample in terms of their individual...

  19. Developing a Motion Comic for HIV/STD Prevention for Young People Ages 15-24, Part 1: Listening to Your Target Audience. (United States)

    Willis, Leigh A; Kachur, Rachel; Castellanos, Ted J; Spikes, Pilgrim; Gaul, Zaneta J; Gamayo, Ashley C; Durham, Marcus; Jones, Sandra; Nichols, Kristen; Han Barthelemy, Solange; LaPlace, Lisa; Staatz, Colleen; Hogben, Matthew; Robinson, Susan; Brooks, John T; Sutton, Madeline Y


    Young people (15-24 years) in the United States are disproportionately affected by infection with human immunodeficiency virus (HIV) and sexually transmitted diseases (STD). Shortfalls in HIV/STD-related knowledge, attitudes, beliefs, and behavioral intentions (KABI) likely contribute to this discrepancy. In this report we describe our experience developing a novel means of health communication combining entertainment-education theory and recent technological advances to create a HIV/STD-focused "motion comic." We also report the audience satisfaction and acceptance of the intervention. We used the Health Belief Model (HBM), entertainment-education (EE) principles, and the Sabido Method (SM) and conducted three rounds of focus groups to develop a 38-minute HIV/STD focused motion comic for young people between the ages 15 and 24 years. Participants indicated that motion comics were an acceptable method of delivering HIV/STD prevention messages. They also expressed satisfaction with motion comics plot, story settings, the tone of humor, and drama. Our results suggest that motion comics are a viable new method of delivering health communication messages about HIV/STD and other public health issues, and warrant further development and broader evaluation.

  20. Description of a MIL-STD-1553B Data Bus Ada Driver for the LeRC EPS Testbed (United States)

    Mackin, Michael A.


    This document describes the software designed to provide communication between control computers in the NASA Lewis Research Center Electrical Power System Testbed using MIL-STD-1553B. The software drivers are coded in the Ada programming language and were developed on a MSDOS-based computer workstation. The Electrical Power System (EPS) Testbed is a reduced-scale prototype space station electrical power system. The power system manages and distributes electrical power from the sources (batteries or photovoltaic arrays) to the end-user loads. The electrical system primary operates at 120 volts DC, and the secondary system operates at 28 volts DC. The devices which direct the flow of electrical power are controlled by a network of six control computers. Data and control messages are passed between the computers using the MIL-STD-1553B network. One of the computers, the Power Management Controller (PMC), controls the primary power distribution and another, the Load Management Controller (LMC), controls the secondary power distribution. Each of these computers communicates with two other computers which act as subsidiary controllers. These subsidiary controllers are, in turn, connected to the devices which directly control the flow of electrical power.

  1. How to Develop and Interpret a Credibility Assessment of Numerical Models for Human Research: NASA-STD-7009 Demystified (United States)

    Nelson, Emily S.; Mulugeta, Lealem; Walton, Marlei; Myers, Jerry G.


    In the wake of the Columbia accident, the NASA-STD-7009 [1] credibility assessment was developed as a unifying platform to describe model credibility and the uncertainties in its modeling predictions. This standard is now being adapted by NASAs Human Research Program to cover a wide range of numerical models for human research. When used properly, the standard can improve the process of code development by encouraging the use of best practices. It can also give management more insight in making informed decisions through a better understanding of the models capabilities and limitations.To a newcomer, the abstractions presented in NASA-STD-7009 and the sheer volume of information that must be absorbed can be overwhelming. This talk is aimed at describing the credibility assessment, which is the heart of the standard, in plain terms. It will outline how to develop a credibility assessment under the standard. It will also show how to quickly interpret the graphs and tables that result from the assessment and how to drill down from the top-level view to the foundation of the assessment. Finally, it will highlight some of the resources that are available for further study.

  2. NASA-STD-6001B Test 7: Impact of Test Methodology and Detection Advancements on the Obsolescence of Historical Offgas Data (United States)

    Buchanan, Vanessa D.; Woods, Brenton; Harper, Susana A.; Beeson, Harold D.; Perez, Horacio; Ryder, Valerie; Tapia, Alma S.; Pedley, Michael D.


    NASA-STD-6001B states "all nonmetals tested in accordance with NASA-STD-6001 should be retested every 10 years or as required by the responsible program/project." The retesting of materials helps ensure the most accurate data are used in material selection. Manufacturer formulas and processes can change over time, sometimes without an update to product number and material information. Material performance in certain NASA-STD-6001 tests can be particularly vulnerable to these changes, such as material offgas (Test 7). In addition, Test 7 analysis techniques at NASA White Sands Test Facility were dramatically enhanced in the early 1990s, resulting in improved detection capabilities. Low level formaldehyde identification was improved again in 2004. Understanding the limitations in offgas analysis data prior to 1990 puts into question the validity and current applicability of that data. Case studies on Super Koropon (Registered trademark) and Aeroglaze (Registered trademark) topcoat highlight the importance of material retesting.

  3. Sexually transmitted diseases in men who have sex with men. Acquisition of gonorrhea and nongonococcal urethritis by fellatio and implications for STD/HIV prevention. (United States)

    Lafferty, W E; Hughes, J P; Handsfield, H H


    Despite trends toward safer sex practices in homosexually active men, some such people remain at high risk for acquiring sexually transmitted diseases (STD). This study was designed to assess behavioral and demographic determinants of STD acquisition in men who have sex with men (MSM), to guide prevention interventions. A cross-sectional medical record review was undertaken of MSM who attended an urban STD clinic from January, 1993 through December, 1994. Gonorrhea, chlamydial infection, Chlamydia-negative nongonococcal urethritis (NGU), and newly documented human immunodeficiency virus (HIV) infection were analyzed in relation to demographic and behavioral variables. Among 1,253 MSM, 196 (15.6%) had nonchlamydial NGU, 105 (8.4%) had gonorrhea, 31 (2.5%) had chlamydial infection, and 162 (12.9%) had known or newly documented HIV infection. Known HIV infection was an independent predictor of urethral gonorrhea (odds ratio [OR] 2.3, 95% confidence interval [CI95] 1.2-4.8). Oral insertive intercourse was independently associated with urethral gonorrhea (OR 4.4, CI95 1.4-13.4) and nonchlamydial NGU (OR 2.2, CI95 1.3-3.7), and receptive anal intercourse was associated with newly documented HIV infection (OR 2.6, CI95 1.3-4.9). Neither number of sex partners nor condom use was associated with any incident STD outcome, including new HIV infection. MSM who attend STD clinics represent a subgroup of homosexually active men who remain at high risk for STDs, including HIV infection. Fellatio, commonly thought to be a "safe" sexual practice, is an independent risk factor for urethral gonorrhea and nonchlamydial NGU. A history of consistent condom use or of few sex partners should not dissuade clinicians from performing screening tests for HIV and other STDs. Repeated STD screening and counseling about safer sex are indicated for many HIV-infected MSM.

  4. Using the theory of reasoned action (TRA) to understand the decision to use condoms in an STD clinic population. (United States)

    Baker, S A; Morrison, D M; Carter, W B; Verdon, M S


    The theory of reasoned action (TRA) provides useful information when designing health education interventions. In this study, 703 heterosexual STD clinic clients responded to a TRA-based survey. With steady partners, social norms and attitudes toward condom use were significant predictors of intention for both men and women. The interaction of attitude and norm increased prediction for men (R = .64, p < 0.001) and women (R = .70, p < 0.001). With casual partners, attitude was a predictor for men and social norm was a predictor for women. Prior use of condoms increased prediction for men (R = .38, p < 0.001) and women (R = .47, p < 0.001). Findings suggest that, in addition to traditional TRA model variables, the relationship between sexual partners and the individual's prior experience with condom use should be incorporated into attempts to understand this complex, dyadic behavior. Examining specific outcome and normative beliefs also provides important information for intervention design.

  5. The Relationships Among Childhood Maltreatment, Emotion Regulation, and Sexual Risk-Taking in Men from Urban STD Clinics. (United States)

    Mueller, Tiffany M; Peterson, Zoë D


    This study sought to examine the relationships among emotion regulation difficulties, childhood maltreatment, and risky sexual behavior in a sample of 320 heterosexual men recruited from urban STD clinics. Overall childhood maltreatment and several specific types of child abuse were significantly associated with emotion dysregulation, number of sexual partners, and STI diagnosis. There was evidence of an additive effect of multiple forms of maltreatment on difficulties with emotion regulation and sexual risk-taking. Impulse control difficulties and access to emotion regulation strategies, two components of emotion dysregulation, were related to measures of risky sexual behavior. Furthermore, limited access to emotion regulation strategies mediated the relationship between frequency of childhood sexual abuse and a greater number of lifetime sexual partners. This study has important implications for developing effective interventions to reduce the spread of STI's and HIV by expanding affect regulation and distress tolerance strategies among men who have experienced childhood maltreatment.

  6. Data harmonization process for creating the National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention Atlas. (United States)

    Elmore, Kim; Nelson, Rob; Gant, Zanetta; Jeffries, Carla; Broeker, Lance; Mirabito, Massimo; Roberts, Henry


    In 2009, the CDC National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP) initiated the online, interactive NCHHSTP Atlas. The goal of the Atlas is to strengthen the capacity to monitor the diseases overseen by NCHHSTP and to illustrate demographic, spatial, and temporal variation in disease patterns. The Atlas includes HIV, AIDS, viral hepatitis, sexually transmitted disease, and tuberculosis surveillance data, and aims to provide a single point of access to meet the analytical and data dissemination needs of NCHHSTP. To accomplish this goal, an NCHHSTP-wide Data Harmonization Workgroup reviewed surveillance data collected by each division to harmonize the data across diseases, allowing one to query data and generate comparable maps and tables via the same user interface. Although we were not able to harmonize all data elements, data standardization is necessary and work continues toward that goal.

  7. PASHA: a collection of promising teen pregnancy and STD / HIV / AIDS prevention programs-in-a-box. (United States)


    Sociometrics Corporation has established the Program Archive on Sexuality, Health and Adolescence (PASHA) to promote the dissemination, creative adaptation, and evaluation of promising teen pregnancy and STD (sexually transmitted disease)/HIV/AIDS prevention programs. To date, it has 30 programs. Sociometrics had developed a package with everything needed to replicate or adapt each promising program in the archive. The package includes a complete set of program materials (e.g., training manuals), a user's guide, and a one-page packaging slip. Two evaluation packets accompany each program. The Be Proud] Be Responsible] AIDS Risk Reduction Program uses discussions of condom use, group participation, role plays, and other oral and written exercises to strive to increase STD/HIV/AIDS knowledge, improve self-pride, and promote safer sexual behaviors. The program entitled Human Sexuality--Values & Choices: A Values-Based Curriculum for 7th and 8th Grades promotes sexual abstinence and healthy social relationships through parent-child communication and a video-assisted format. The Reducing the Risk program is for high school students and aims to change student norms about unprotected sexual intercourse and perceptions of peer sexual activity and to strengthen parent-child communication on abstinence and contraception. The School/Community Program for Sexual Risk Reduction among Teens aims to motivate the entire community in preventing pregnancy among unmarried teens. Targeted training and workshops sites include public schools, universities, church groups, and civic organizations. It promotes abstinence as the preferred sexual health decision, but effective contraception for teens who become sexually active. Teen Talk is a collaborative school- and community health centers-based sexuality education intervention. It provides large group, lecture format presentations on reproductive physiology, contraceptive methods, and contraceptive effectiveness and various sessions

  8. Investigating stakeholders' perceptions of the link between high STD rates and the current Baltimore City Public Schools' sex education curriculum (United States)

    Bolden, Shenell L. T.

    The purpose of this exploratory study was to examine key stakeholders' perceptions of the current Baltimore City Public Schools' (BCPS) sex education curriculum and to gain insight into how they believe the curriculum could be modified to be more effective. A mixed methods approach using qualitative and quantitative data collection consisting of a survey, focus group interview, and individual interviews was conducted to gather information on stakeholders' perceptions. The stakeholders included: (1) former students who received their sex education courses in the Baltimore City Public School system (BCPS); (2) teachers in BCPS who were affiliated with the sex education curriculum; (3) health care professionals who screened and/or treated East Baltimore City residents for a sexually transmitted disease (STD) and; (4) one policy maker who was responsible for creating sex education curriculum at the national level. Analysis of the quantitative data from former Baltimore City Public School students revealed a general satisfaction with the current sex education curriculum. However, qualitative data from the same group of stakeholders revealed several changes they thought should be implemented into the program in an effort to improve the current curriculum. Findings from the other groups after qualitative analysis of the interviews suggest three major themes in support of curriculum change: (1) a blended curriculum that integrates both the cognitive and affective learning domains; (2) knowledge of prevention of STD's and pregnancy; and (3) authentic teaching and learning. Results from this study strongly suggest that the Baltimore City Public School system is apathetic to the sexual health needs of students and, therefore, is inadvertently contributing to the high rate of sexually transmitted diseases among young people. Keywords: Abstinence, Affective domain, Indoctrination, Behavior Modification, Cognitive domain, Sex education curriculum, Sexually Transmitted Diseases.

  9. School-Based HIV/STD Testing Behaviors and Motivations among Black and Hispanic Teen MSM: Results from a Formative Evaluation (United States)

    Morris, Elana; Topete, Pablo; Rasberry, Catherine N.; Lesesne, Catherine A.; Kroupa, Elizabeth; Carver, Lisa


    Background: This evaluation explores experiences with, and motivations for, human immunodeficiency virus (HIV) and sexually transmitted disease (STD) testing among black and Hispanic school-aged young men who have sex with men (YMSM). Methods: Participants were recruited at community-based organizations that serve YMSM in New York City,…

  10. Potential Impact and Acceptability of Internet Partner Notification for Men Who Have Sex with Men and Transgender Women Recently Diagnosed with STD in Lima, Peru (United States)

    Clark, Jesse L; Segura, Eddy R; Perez-Brumer, Amaya G; Reisner, Sari L; Peinado, Jesus; Salvatierra, Hector J; Sanchez, Jorge; Lama, Javier R


    We assessed the potential impact of internet partner notification (PN) among MSM and transgender women in Peru recently diagnosed with STD. Use of internet PN was anticipated for 55.9% of recent partners, including 43.0% of partners not currently expected to be notified, a 20.6% increase in anticipated notification outcomes. PMID:24326581

  11. Anticipated Notification of Sexual Partners following STD Diagnosis among Men Who Have Sex with Men and Transgender Women in Lima, Peru: A Mixed Methods Analysis (United States)

    Clark, Jesse L.; Perez-Brumer, Amaya G.; Segura, Eddy R.; Salvatierra, Hector J.; Sanchez, Jorge; Lama, Javier R.


    Background New strategies to support partner notification (PN) are critical for STD control and require detailed understanding of how specific individual and partnership characteristics guide notification decisions. Methods From 2011 to 2012, 397 MSM and TW recently diagnosed with HIV, syphilis, or another STD completed a survey on anticipated notification of recent sexual partners and associated factors. Qualitative interviews were conducted with a subset of participants to provide further depth to quantitative findings. Prevalence ratios and generalized estimating equation (GEE) models were used to analyze participant- and partner-level factors associated with anticipated PN. Results Among all partners reported, 52.5% were described as “Very Likely” or “Somewhat Likely” to be notified. Anticipated notification was more likely for main partners than casual (adjusted Prevalence Ratio [aPR], 95% CI: 0.63, 0.54–0.75) or commercial (aPR, 95% CI: 0.44, 0.31–0.62) partners. Other factors associated with likely notification included perception of the partner as an STD source (aPR, 95% CI: 1.27, 1.10–1.48) and anticipated future sexual contact with the partner (aPR, 95% CI: 1.30, 1.11–1.52). An HIV diagnosis was associated with a lower likelihood of notification than non-HIV STDs (aPR: 0.68, 0.55–0.86). Qualitative discussion of the barriers and incentives to PN reflected a similar differentiation of anticipated notification according to partnership type and type of HIV/STD diagnosis. Discussion Detailed attention to how partnership characteristics guide notification outcomes is essential to the development of new PN strategies. By accurately and thoroughly assessing the diversity of partnership interactions among individuals with HIV/STD, new notification techniques can be tailored to partner-specific circumstances. PMID:27685158

  12. Addiction and sexually transmitted disease (STD), human immunodeficiency virus, (HIV), and acquired immune deficiency syndrome (AIDS): their mutual interactions. (United States)

    Adrian, Manuella


    We explore the links between substance use, misuse, addiction, and dependency1 and sexuality, sexually transmitted diseases (STD), human immunodeficiency virus (HIV), and acquired immune deficiency syndrome (AIDS) to increase our awareness of their interdependence and to identify new ways to perceive, judge, and intervene (or not to) with associated problems. We consider the sociocultural and economic context in which these behaviors occur; the impact these behaviors have on one another; the personal opinions and attitudes; the religious, moral, or political beliefs and agendas; the physiological and fiscal constraints; and theories of rational decision-making and psychological motivation that act to increase or reduce the incidence of these behaviors and their sequellae, while hindering or facilitating prevention, harm reduction, and treatment interventions. Mechanisms of epidemic spread of STDS/HIV/AIDS are presented in the Appendix. Each of these terms are loaded "container concepts" that are culture-bound and stakeholder-driven and whose dimensions are less than consensus-based. They represent a range of meanings, uses, and misuses in an ongoing politicalized area of human and systemic functioning and adaptations.

  13. Characterization of Representative Materials in Support of Safe, Long Term Storage of Surplus Plutonium in DOE-STD-3013 Containers

    Energy Technology Data Exchange (ETDEWEB)

    Narlesky, Joshua E. [Los Alamos National Laboratory; Stroud, Mary Ann [Los Alamos National Laboratory; Smith, Paul Herrick [Los Alamos National Laboratory; Wayne, David M. [Los Alamos National Laboratory; Mason, Richard E. [MET-1: ACTINIDE PROCESSING SUPPORT; Worl, Laura A. [Los Alamos National Laboratory


    The Surveillance and Monitoring Program is a joint Los Alamos National Laboratory/Savannah River Site effort funded by the Department of Energy-Environmental Management to provide the technical basis for the safe, long-term storage (up to 50 years) of over 6 metric tons of plutonium stored in over 5,000 DOE-STD-3013 containers at various facilities around the DOE complex. The majority of this material is plutonium that is surplus to the nuclear weapons program, and much of it is destined for conversion to mixed oxide fuel for use in US nuclear power plants. The form of the plutonium ranges from relatively pure metal and oxide to very impure oxide. The performance of the 3013 containers has been shown to depend on moisture content and on the levels, types and chemical forms of the impurities. The oxide materials that present the greatest challenge to the storage container are those that contain chloride salts. Other common impurities include oxides and other compounds of calcium, magnesium, iron, and nickel. Over the past 15 years the program has collected a large body of experimental data on 54 samples of plutonium, with 53 chosen to represent the broader population of materials in storage. This paper summarizes the characterization data, moisture analysis, particle size, surface area, density, wattage, actinide composition, trace element impurity analysis, and shelf life surveillance data and includes origin and process history information. Limited characterization data on fourteen nonrepresentative samples is also presented.

  14. JPL Thermal Design Modeling Philosophy and NASA-STD-7009 Standard for Models and Simulations - A Case Study (United States)

    Avila, Arturo


    The Standard JPL thermal engineering practice prescribes worst-case methodologies for design. In this process, environmental and key uncertain thermal parameters (e.g., thermal blanket performance, interface conductance, optical properties) are stacked in a worst case fashion to yield the most hot- or cold-biased temperature. Thus, these simulations would represent the upper and lower bounds. This, effectively, represents JPL thermal design margin philosophy. Uncertainty in the margins and the absolute temperatures is usually estimated by sensitivity analyses and/or by comparing the worst-case results with "expected" results. Applicability of the analytical model for specific design purposes along with any temperature requirement violations are documented in peer and project design review material. In 2008, NASA released NASA-STD-7009, Standard for Models and Simulations. The scope of this standard covers the development and maintenance of models, the operation of simulations, the analysis of the results, training, recommended practices, the assessment of the Modeling and Simulation (M&S) credibility, and the reporting of the M&S results. The Mars Exploration Rover (MER) project thermal control system M&S activity was chosen as a case study determining whether JPL practice is in line with the standard and to identify areas of non-compliance. This paper summarizes the results and makes recommendations regarding the application of this standard to JPL thermal M&S practices.

  15. Delivering laboratory results by text message and e-mail: a survey of factors associated with conceptual acceptability among STD clinic attendees. (United States)

    Tripathi, Avnish; Duffus, Wayne A; Kissinger, Patricia; Brown, Timothy J; Gibson, James J; Mena, Leandro A


    This study examines factors associated with the acceptability of receiving sexually transmitted disease (STD) laboratory results by text message and e-mail among clinic attendees. An anonymous self-administered survey was conducted with a convenience sample of STD clinic attendees in South Carolina and Mississippi in 2009-2010. In total, 2,719 individuals with a median age of 26 years (interquartile range, 21-32 years) completed the survey. More than 70% had Internet access at home, and 80% reported using text messaging daily. Participants preferred receiving laboratory results by text message compared with e-mail (50.2% versus 42.3%; p<0.001). Acceptability of receiving laboratory results by text message was higher with younger age (adjusted odds ratio [aOR] 1.13; 95% confidence interval [CI] 1.10-1.26), daily use of text messaging (aOR 1.30; 95% CI 1.14-1.49), and reporting cell phone and text message as the preferred choice of regular communication with the clinic (aOR 2.31; 95% CI 1.50-3.58) and was significantly lower in female subjects (aOR 0.89; 95% CI 0.81-0.98) and those with college-level education (aOR 0.88; 95% CI 0.77-0.99). A majority of STD clinic attendees have access to cell phones and Internet. The acceptability of receiving STD laboratory results electronically may facilitate test result delivery to patients and expedite treatment of infected individuals.

  16. PSA de radio Mes de Concientización sobre las ETS PSA de radio (30 seg) (STD Awareness Month PSA (:30))

    Centers for Disease Control (CDC) Podcasts


    Abril es el Mes Nacional de Concientización sobre las Enfermedades de Transmisión Sexual (ETS). Las ETS pueden afectar a cualquier persona. Muchas ETS no tienen síntomas, por lo que es importante hacerse pruebas de detección.  Created: 4/19/2011 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention.   Date Released: 4/20/2011.

  17. Use of a Business Approach to Improve Disease Surveillance Data Management Systems and Information Technology Process in Florida's Bureau of STD Prevention and Control. (United States)

    Shiver, Stacy A; Schmitt, Karla; Cooksey, Adrian


    The business of sexually transmitted disease (STD) prevention and control demands technology that is capable of supporting a wide array of program activities-from the processing of laboratory test results to the complex and confidential process involved in contact investigation. The need for a tool that enables public health officials to successfully manage the complex operations encountered in an STD prevention and control program, and the need to operate in an increasingly poor resource environment, led the Florida Bureau of STD to develop the Patient Reporting Investigation Surveillance Manager. Its unique approach, technical architecture, and sociotechnical philosophy have made this business application successful in real-time monitoring of disease burden for local communities, identification of emerging outbreaks, monitoring and assurance of appropriate treatments, improving access to laboratory data, and improving the quality of data for epidemiologic analysis. Additionally, the effort attempted to create and release a product that promoted the Centers for Disease Control and Prevention's ideas for integration of programs and processes.

  18. Proceedings of the Technical Forum (3rd) on the F-16 MIL-STD-1750A Microprocessor and the F-16 MIL-STD-1589B Compiler Held at Wright-Patterson AFB, OH on May 5-6, 1982. Volume 1. Papers, (United States)


    to common business, technical or educational needs. Software associated with MIL-SPEC, MIL-STD or special purpose computers designed for tactical...few features of 13L-I tecnology . I-L is a bipolar technology. As opposed to TTL which is based upon a multiple-input, single-output transistor, I3

  19. Alcohol consumption, drug use, and condom use among STD clinic patients. (United States)

    Scott-Sheldon, Lori A J; Carey, Michael P; Vanable, Peter A; Senn, Theresa E; Coury-Doniger, Patricia; Urban, Marguerite A


    Research on the association between substance use and sexual risk behavior has yielded a complex pattern of findings. Such inconsistent findings may reflect method variance, including factors such as gender of the participant, nature of the sexual event, partner characteristics, and type of substance used. The purpose of this study was to investigate the association between substance use and unprotected sex independently for alcohol, drugs, or combined substance use and to examine partner characteristics as a moderator of this association. Participants (N = 1,419; 48% women) were recruited from a publicly funded sexually transmitted disease clinic and were asked to complete an audio computer-assisted self-interview regarding their most recent sexual experience, including nature of the event, substance use, and partner characteristics. Analyses showed that alcohol use was related to condom use when gender and partner type were considered; thus, for women, but not for men, partner type interacted with alcohol consumption such that condom use was less likely when alcohol consumption preceded sex with nonprimary partners (drinking was unrelated to condom use with primary partners). Subsequent analyses examining partner substance use showed that women, but not men, who reported both they and their nonprimary partners were drinking during sex were less likely to use a condom. At the event level, alcohol consumption among sexually transmitted disease clinic patients is associated with condom use, but this association differs by gender and partner characteristics. Findings suggest the need to strengthen substance-use components in sexual risk reduction interventions for women and their partners.

  20. Temperature profile data from STD/CTD casts from the MOANA WAVE from the Pacific Ocean during the International Decade of Ocean Exploration / North Pacific Experiment (IDOE/NORPAX) project, 22 February to 1975-05-27 (NODC Accession 7800703) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature and salinity profile data were collected using STD/CTD casts from MOANA WAVE in the Pacific Ocean from February 22, 1975 to May 27, 1975. Data were...

  1. Temperature and salinity from bottle and STD casts from the ACONA part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 09 October 1974 to 27 March 1975 (NODC Accession 7601139) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hydrochemical, hydrophysical, meteorological, and other data were collected from surface sensors, bottle casts, and STD casts from the ACONA. Data were collected by...

  2. Temperature and salinity profiles from STD casts in the Bering Sea from the SILAS BENT as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 01 September 1975 to 26 September 1975 (NODC Accession 7600747) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature and salinity profiles were collected from STD casts in the Bering Sea from the SILAS BENT. Data were collected by the University of Alaska - Fairbanks...

  3. Temperature and salinity profiles from bottle and STD casts in the Bering Sea from the ACONA as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 02 July 1974 to 10 July 1974 (NODC Accession 7601138) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature and salinity profiles were collected from bottle and STD casts in the Bering Sea from the ACONA. Data were collected by the University of Alaska -...

  4. Temperature profiles from STD casts from the Oregon Coast from the YAQUINA as part of the International Decade of Ocean Exploration / Coastal Upwelling Ecosystems Analysis (IDOE/CUEA) from 07 August 1972 to 26 August 1972 (NODC Accession 9800111) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from STD casts from the Oregon Coast from the YAQUINA from 07 August 1972 to 26 August 1972. Data were collected by the...

  5. Estudio experimental de potencias, factor de potencia y energía eléctrica en cargas industriales tomando como referencia la norma IEEE Std 1459-2010

    National Research Council Canada - National Science Library

    Alexander Daza Urrego; Clara Inés Buriticá Arboleda; Yaqueline Garzón Rodríguez


    .... This article takes an experimental study for electrical variables from the provisions of the methodology outlined by IEEE Std 1459-2010, which is taken as a reference to compare values for reactive...

  6. (STD) Patients in Malawi

    African Journals Online (AJOL)

    independent risk factor for HIV transmission}·2 Ulcerative dis- eases have been shown to increase the risk of HIV transmission three to five-fold in prospective studies.3. •. 4 Non-ulcerative STDs, such as gonorrhea, chlamydia, and trichomonas also increase the risk of HIV transmission.5 Estimations of the attributable risk of.

  7. [Knowledge, attitudes and practices related to STD and HIV/AIDS: men having sex with men in Senegal]. (United States)

    Ndiaye, P; Fall, A; Tal-Dia, A; Faye, A; Diongue, M


    This study aimed to review knowledge, attitudes and practices related to sexual transmitted diseases (STD) and HIV/AIDS among men who have sex with men (MSM) in Senegal. The study was undertaken from February 1st to June 30th 2007, in three capitals cities in Senegal (one national, and two regional). It concerned the MSM that benefited from at least one of services of an MSM association. Studied variables included socio demographic characteristics, sexual practices, as well as knowledge and attitudes related to STDs and VIH/AIDS. Interviews took place during appointments obtained by direct phone call or by two MSM leaders intermediary. Data were seized and analyzed with Epi2000 Software. Among 245 registered MSM, 63 had a precise contact (address and/or phone number), and 49 aged in average of 25 years were investigated. Among them, one was illiterate, five studied Koran, seven Arab and 36 French. The socio-professional categories differentiated two officials, two merchants, one mechanic, one fighter, five artists, five restorers, seven tailors, 11 students, and 15 unemployed. The associations, to which 35 HSH belonged, were related to sexuality (66%), religion (20%), social matters (8%) and economy (6%). Sexual habits, according to anal intercourse, differentiated the "Ubbi" or receptive/passive (57%), the "Yoos" or incertif/active (25%), the "Ubbi/Yoos" who play the two roles (14%) and the "neitherUbbi/norYoos" who had other practices than anal (4%). Practices between men, concerned mutual strokes (100%), fellatio (61%) and anal intercourse (49%), counted 45% for remuneration, 35% of multi-unprotected partnership, and 12% of breaking condom. Practices with women were reported by 15 MSM (31%). Concerning STDs, at least one sign was reported by 43 MSM, one transmission way by 42, one mean of protection by 47; and the first recourse was a health system for 36 MSM. The test of HIV/AIDS screening was done by 38 HSH among which 30 withdrew the results. The "Ubby

  8. Multiplex immunoassay of lower genital tract mucosal fluid from women attending an urban STD clinic shows broadly increased IL1ß and lactoferrin.

    Directory of Open Access Journals (Sweden)

    Gregory T Spear

    Full Text Available BACKGROUND: More than one million new cases of sexually transmitted diseases (STDs occur each day. The immune responses and inflammation induced by STDs and other frequent non-STD microbial colonizations (i.e. Candida and bacterial vaginosis can have serious pathologic consequences in women including adverse pregnancy outcomes, infertility and increased susceptibility to infection by other pathogens. Understanding the types of immune mediators that are elicited in the lower genital tract by these infections/colonizations can give important insights into the innate and adaptive immune pathways that are activated and lead to strategies for preventing pathologic effects. METHODOLOGY/PRINCIPAL FINDINGS: 32 immune mediators were measured by multiplexed immunoassays to assess the immune environment of the lower genital tract mucosa in 84 women attending an urban STD clinic. IL-3, IL-1ß, VEGF, angiogenin, IL-8, ß2Defensin and ß3Defensin were detected in all subjects, Interferon-α was detected in none, while the remaining mediators were detected in 40% to 93% of subjects. Angiogenin, VEGF, FGF, IL-9, IL-7, lymphotoxin-α and IL-3 had not been previously reported in genital mucosal fluid from women. Strong correlations were observed between levels of TNF-α, IL-1ß and IL-6, between chemokines IP-10 and MIG and between myeloperoxidase, IL-8 and G-CSF. Samples from women with any STD/colonization had significantly higher levels of IL-8, IL-3, IL-7, IL-1ß, lactoferrin and myeloperoxidase. IL-1ß and lactoferrin were significantly increased in gonorrhea, Chlamydia, cervicitis, bacterial vaginosis and trichomoniasis. CONCLUSIONS/SIGNIFICANCE: These studies show that mucosal fluid in general appears to be an environment that is rich in immune mediators. Importantly, IL-1ß and lactoferrin are biomarkers for STDs/colonizations providing insights into immune responses and pathogenesis at this mucosal site.

  9. Quantity, not frequency, of alcohol use moderates the association between multiple sexual partners and Trichomonas vaginalis among women attending an urban STD clinic. (United States)

    Scott-Sheldon, Lori A J; Senn, Theresa E; Carey, Kate B; Urban, Marguerite A; Carey, Michael P


    The purpose of this study is to investigate alcohol use, sexual risk behaviour and trichomoniasis in a sample of low-income, largely minority, women patients at a publicly funded sexually transmitted disease (STD) clinic in the USA. Baseline data, collected as part of a clinical trial, were used. Patients (688 women, 46% of the overall sample) completed an audio computer-assisted self-interview that included questions about their alcohol use and sexual behaviours. Trichomoniasis was determined from vaginal swab specimens obtained during a standard clinical exam. Women (n=580; 18-56 years of age; 64% African-American) who reported that they had consumed alcohol at least once in the past year were included in the analyses. Of the 580 women, 157 were diagnosed with an STD and 80 tested positive for trichomoniasis. Trichomoniasis was associated with having multiple sexual partners (OR=1.09; 95% CI 1.01 to 1.17) but not with the number or proportion of unprotected sex events (p>0.05) in the past 3 months. Quantity of alcohol use (drinks per drinking day, drinks per week, and peak consumption) moderated the association between the number of sexual partners and trichomoniasis. The number of sexual partners predicted the probability of trichomoniasis when women reported drinking large quantities of alcohol. Because having multiple sexual partners increases the risk for STD transmission, interventions designed for at-risk women should address the quantity of alcohol consumed as well as partner reduction to reduce the risk for trichomoniasis.

  10. A real time data acquisition system using the MIL-STD-1553B bus. [for transmission of data to host computer for control law processing (United States)

    Peri, Frank, Jr.


    A flight digital data acquisition system that uses the MIL-STD-1553B bus for transmission of data to a host computer for control law processing is described. The instrument, the Remote Interface Unit (RIU), can accommodate up to 16 input channels and eight output channels. The RIU employs a digital signal processor to perform local digital filtering before sending data to the host. The system allows flexible sensor and actuator data organization to facilitate quick control law computations on the host computer. The instrument can also run simple control laws autonomously without host intervention. The RIU and host computer together have replaced a similar larger, ground minicomputer system with favorable results.

  11. Facilitating NASA's Use of GEIA-STD-0005-1, Performance Standard for Aerospace and High Performance Electronic Systems Containing Lead-Free Solder (United States)

    Plante, Jeannete


    GEIA-STD-0005-1 defines the objectives of, and requirements for, documenting processes that assure customers and regulatory agencies that AHP electronic systems containing lead-free solder, piece parts, and boards will satisfy the applicable requirements for performance, reliability, airworthiness, safety, and certify-ability throughout the specified life of performance. It communicates requirements for a Lead-Free Control Plan (LFCP) to assist suppliers in the development of their own Plans. The Plan documents the Plan Owner's (supplier's) processes, that assure their customer, and all other stakeholders that the Plan owner's products will continue to meet their requirements. The presentation reviews quality assurance requirements traceability and LFCP template instructions.

  12. Empirical approach for single attributes sampling plans design under normal inspection based on standards COVENIN 3133-1:2001 and MIL-STD-105E

    Directory of Open Access Journals (Sweden)

    Mairett Rodríguez-Balza


    Full Text Available (Received: 2015/05/02 - Accepted: 2015/06/11An empirical rule is proposed for determining the sample size n to be taken depending on the lot produced size N for a single attributes sampling under normal inspection based on the standards COVENIN 3133-1: 2001 and MIL-STD-105E; also, the acceptance number c for a given level of acceptable quality was calculated, and the corresponding operating characteristic curves were constructed. Two potential regression equations were obtained for calculation of sample size to fit R2 of 99.91% and 99.38% for lot sizes N≤666 and N>666, respectively, in addition, a sampling plan was designed for a lot size of 176,000 units with an acceptable level of quality of 0.65% defectives units. The proposed sampling plan presented a smaller sample size (n=560 than the standard (n=800, with operating characteristic curve very similar to the closest sampling plan recommended by the standard (n=500. The application of the empirical approach is recommended for the design of cheaper sampling plans which in turn are consonant with the rules COVENIN 3133-1: 2001 and MIL-STD-105E

  13. Domain-specific interactions between MLN8237 and human serum albumin estimated by STD and WaterLOGSY NMR, ITC, spectroscopic, and docking techniques (United States)

    Yang, Hongqin; Liu, Jiuyang; Huang, Yanmei; Gao, Rui; Tang, Bin; Li, Shanshan; He, Jiawei; Li, Hui


    Alisertib (MLN8237) is an orally administered inhibitor of Aurora A kinase. This small-molecule inhibitor is under clinical or pre-clinical phase for the treatment of advanced malignancies. The present study provides a detailed characterization of the interaction of MLN8237 with a drug transport protein called human serum albumin (HSA). STD and WaterLOGSY nuclear magnetic resonance (NMR)-binding studies were conducted first to confirm the binding of MLN8237 to HSA. In the ligand orientation assay, the binding sites of MLN8237 were validated through two site-specific spy molecules (warfarin sodium and ibuprofen, which are two known site-selective probes) by using STD and WaterLOGSY NMR competition techniques. These competition experiments demonstrate that both spy molecules do not compete with MLN8237 for the specific binding site. The AutoDock-based blind docking study recognizes the hydrophobic subdomain IB of the protein as the probable binding site for MLN8237. Thermodynamic investigations by isothermal titration calorimetry (ITC) reveal that the non-covalent interaction between MLN8237 and HSA (binding constant was approximately 105 M-1) is driven mainly by favorable entropy and unfavorable enthalpy. In addition, synchronous fluorescence, circular dichroism (CD), and 3D fluorescence spectroscopy suggest that MLN8237 may induce conformational changes in HSA.

  14. Systematic review of sexual risk among pregnant and mothering teens in the USA: pregnancy as an opportunity for integrated prevention of STD and repeat pregnancy. (United States)

    Meade, Christina S; Ickovics, Jeannette R


    Behaviors that lead to teen pregnancy also place young women at risk for STDs and repeat pregnancy. Compared to the broad literature on adolescent sexual risk behavior, our understanding of sexual risk in pregnant/mothering teens lags far behind. Primary objectives of this systematic review (1981-2003) of pregnant/mothering teens were to: (1) document rates of STD, repeat pregnancy, condom use, and contraception; (2) identify correlates of these biological and behavioral outcomes; (3) review sexual risk reduction interventions; and (4) discuss directions for future research and implications for clinical care. Fifty-one studies met inclusion criteria. Rates of STD and repeat pregnancy were high, with the majority of teens engaging in unprotected sex during and after pregnancy. An Ecological Model of Sexual Risk, based on Bronfenbrenner's (1989) Ecological Systems Theory, was proposed to organize findings on correlates of sexual risk. Improvements in research, including integration of outcomes and risk factors, stronger methodologies, and standardized assessments, are essential. Results suggest that teen pregnancy is a marker for future sexual risk behavior and adverse outcomes, and that pregnant/mothering teens need hybrid interventions promoting dual use of condoms and hormonal contraception. Pregnancy may provide a critical "window of opportunity" for sexual risk reduction.

  15. 1H NMR studies of binary and ternary dapsone supramolecular complexes with different drug carriers: EPC liposome, SBE-β-CD and β-CD. (United States)

    Martins, Lucas; Arrais, Monica; de Souza, Alexandre; Marsaioli, Anita


    Binary and ternary systems composed of dapsone, sulfobutylether-β-cyclodextrin (SBE-β-CD), β-CD and egg phosphatidylcholine (EPC) were evaluated using 1D ROESY, saturation transfer difference NMR and diffusion experiments (DOSY) revealing the binary complexes Dap/β-CD (K(a) 1396 l mol(-1)), Dap/SBE-β-CD (K(a) 246 l mol(-1)), Dap/EPC (K(a) 84 l mol(-1)) and the ternary complex Dap/β-CD/EPC (K(a) 18 l mol(-1)) in which dapsone is more soluble. Copyright © 2014 John Wiley & Sons, Ltd.

  16. Rancang Bangun dan Studi Eksperimen Alat Penukar Panas untuk Memanfaatkan Energi Referigerant Keluar Kompresor AC sebagai Pemanas Air pada ST/D=4 dengan Variasi Volume Air

    Directory of Open Access Journals (Sweden)

    Binar Kusumah Bagja


    Full Text Available Sistem referigerasi memiliki energi yang besar dalam melepaskan kalor. Kalor akibat kompresi pada kompresor bisa dimanfaatkan misalnya untuk pemanasan air. Pemanfaatan kalor tersebut dilakukan dengan cara menambahkan water heater sebelum aliran fluida referigeran masuk ke kondensor. Water heater tersebut dalam keadaan tercelup di dalam sebuah tangki berisi air untuk melepas kalor terhadap air. Perancangan water heater dilakukan dengan mencari panjang tube (L, diameter tube (D, dan jarak antar tube. Water Heater ini diletakkan setelah komponen kompressor pada sistem AC. Proses awal untuk mencari rancangan water heater adalah dengan mencari temperatur keluaran kompresor dimana untuk mencari potensi panas yang akan dimanfaatkan untuk memanaskan air. Setelah mencari potensi panas yang dihasilkan dari energi keluaran kompresor adalah mencari kapasitas kalor yang akan diberikan water heater terhadap air dan kemudian selanjutnya mencari perpindahan panas yang terjadi pada proses pemanasan air tersebut yang kemudian dilakukan perhitungan untuk mencari panjang tube (L dan penentuan jarak ST/D pada tube. Setelah diperoleh geometri water heater, langkah selanjutnya adalah melakukan simulasi numerik dengan menggunakan perangkat lunak FLUENT 6.3.2 untuk mengetahui karaketeristik perpindahan panas yang terjadi di dalam proses pemanasan air dengan jarak ST/D yang telah ditentukan sebelumnya. Langkah selanjutnya melakukan eksperimen. Eksperimen dilakukan dengan memvariasikan volume air dalam tangki yaitu sebesar 75 liter; 85 liter; dan 100 liter. Hasil simulasi numerik diperoleh bahwa pola aliran kecepatan dengan nilai tertinggi berada pada daerah sekitaran tube inlet dikarenakan temperatur yang paling tinggi dibandingkan tube lainnya sehingga menimbulkan perbedaan temperatur dan juga densitas pada sekitaran tube inlet. Hasil eksperimen diperoleh bahwa volume air yang besar yaitu sebesar 100 liter memiliki Coefficient of Performance (COP tertinggi yaitu sebesar

  17. Composite Monopack for 120mm Mortar, With Plastic Pallet Adapters on a 42" x 53" Wooden Pallet, MIL-STD-1660 Tests, "Design Criteria for Ammunition Unit Loads", and Extreme Temperature Tests

    National Research Council Canada - National Science Library

    Dugan, Jeffery L


    ... (AMSRD-AAR-AIL-P) to conduct MIL-STD-1660 Tests to determine if the composite monopack for the 120MM mortar, with plastic pallet adapters on a 42" x 53" wooden pallet, designed by US Army ARDEC and manufactured...

  18. Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S-Component of the Energy-Coupling Factor Transporter for Thiamine. (United States)

    Monjas, Leticia; Swier, Lotteke J Y M; Setyawati, Inda; Slotboom, Dirk J; Hirsch, Anna K H


    We applied dynamic combinatorial chemistry (DCC) to identify ligands of ThiT, the S-component of the energy-coupling factor (ECF) transporter for thiamine in Lactococcus lactis. We used a pre-equilibrated dynamic combinatorial library (DCL) and saturation-transfer difference (STD) NMR spectroscopy to identify ligands of ThiT. This is the first report in which DCC is used for fragment growing to an ill-defined pocket, and one of the first reports for its application with an integral membrane protein as target. © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

  19. Screening protein-ligand interactions using {sup 1}H NMR techniques for detecting the ligand; Mapeamento das interacoes proteina-ligante atraves de tecnicas de RMN de {sup 1}H utilizando deteccao do ligante

    Energy Technology Data Exchange (ETDEWEB)

    Figueiredo, Isis Martins; Marsaioli, Anita Jocelyne [Universidade Estadual de Campinas (UNICAMP), SP (Brazil). Inst. de Quimica. Dept. de Quimica Organica]. E-mail:


    NMR is a valuable screening tool for the binding of ligands to proteins providing structural information on both protein and ligands and is thus largely applied to drug-discovery. Among the recent NMR techniques to probe weak binding protein-ligand complexes we have critically evaluated the advantages and disadvantages of STD (Saturation Transfer Difference), WaterLOGSY (Water Ligand Observation with Gradient Spectroscopy), NOE pumping and DOSY-NOESY (Diffusion-Ordered NOESY) using a mixture of BSA (bovine serum albumin) plus salicylic acid, caffeine, citric acid, adipic acid and D-glucose. (author)

  20. The relationship between recent alcohol use and sexual behaviors: gender differences among sexually transmitted disease clinic patients. (United States)

    Hutton, Heidi E; McCaul, Mary E; Santora, Patricia B; Erbelding, Emily J


    Binge drinking is associated with risky sexual behaviors and sexually transmitted diseases (STDs). Few studies have investigated this by gender or in an STD clinic. This cross-sectional study examined the association between binge drinking and risky sexual behaviors/STDs among patients attending an urban STD clinic. A total of 671 STD clinic patients were tested for STDs, and queried about recent alcohol/drug use and risky sexual behaviors using audio computer-assisted-self-interview. The association between binge drinking and sexual behaviors/STDs was analyzed using logistic regression adjusting for age, employment, and drug use. Binge drinking was reported by 30% of women and 42% of men. Gender differences were found in rates of receptive anal sex which increased linearly with increased alcohol use among women but did not differ among men. Within gender analyses showed that women binge drinkers engaged in anal sex at more than twice the rate of women who drank alcohol without binges (33.3% vs. 15.9%; p women who abstained from alcohol (11.1%; p women binge drinkers than women abstainers (40.5% vs. 16.8%; p women binge drinkers compared to women abstainers (10.6% vs. 2.2%; p sexual behaviors/gonorrhea remained after controlling for drug use. Among men, rates of risky sexual behaviors/STDs were high, but did not differ by alcohol use. Rates of binge drinking among STD clinic patients were high. Among women, binge drinking was uniquely associated with risky sexual behaviors and an STD diagnosis. Our findings support the need to routinely screen for binge drinking as part of clinical care in STD clinics. Women binge drinkers, in particular, may benefit from interventions that jointly address binge drinking and risky sexual behaviors. Developing gender-specific interventions could improve overall health outcomes in this population.

  1. Interseccionalidade de gênero, classe e raça e vulnerabilidade de adolescentes negras às DST/aids Intersectionality of gender, class and race, and vulnerability of black female adolescents to STD/AIDS

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    Stella R. Taquette


    Full Text Available OBJETIVO: verificar a vulnerabilidade ao HIV/aids de adolescentes femininas moradoras de favelas da cidade do Rio de Janeiro. MÉTODO: foi utilizada uma combinação de métodos, quantitativo e qualitativo. Na etapa quantitativa, realizou-se um estudo observacional de corte transversal por meio de entrevistas e exames clínico/laboratoriais para diagnóstico de DST, e, na qualitativa, desenvolveram-se grupos focais sobre os temas sexualidade, gênero e raça. RESULTADOS: foram entrevistadas 816 adolescentes de 10 diferentes comunidades, com um grupo focal em cada favela: 74% eram negras, 39% eram sexualmente ativas e destas 24,4% eram portadoras de DST. Houve uma relação estatisticamente significativa entre a variável raça/cor negra e a atividade sexual. Na fase qualitativa, evidenciou-se que a discriminação racial sofrida é cotidiana e contribui para a construção de autoimagem negativa que aliada a pobreza, violência de gênero e dificuldade de acesso aos serviços de saúde ampliam a vulnerabilidade às DST/aids. CONCLUSÃO: o estudo sugere a criação de políticas que proporcionem o aumento da oferta de serviços de atendimento ginecológico a esse público, com ações que favoreçam a utilização de preservativo feminino e contribuam para reduzir a desigualdade social, de gênero e de raça.OBJECTIVE: To verify the vulnerability to HIV/AIDS of female adolescents that live in poor communities of the city of Rio de Janeiro. METHODS: It was carried out with quantitative and qualitative analyses. The quantitative phase was a cross-sectional study, through interviews of 816 adolescents and clinical/laboratory tests in ten different slums, and the qualitative phase was done on one focus group about sexuality of gender and race in each community. RESULTS: 74% of the adolescents were black, 39% had sexual activity and 24.4% of those had STD. A statistical significant association occurred between the black color/race and sexual activity

  2. HPV-associated flat penile lesions in men of a non-STD hospital population: less frequent and smaller in size than in male sexual partners of women with CIN. (United States)

    Bleeker, Maaike C G; Hogewoning, Cornelis J A; Voorhorst, Feja J; van den Brule, Adriaan J C; Berkhof, Johannes; Hesselink, Albertus T; Lettink, Marjolein; Starink, Theo M; Stoof, Tom J; Snijders, Peter J F; Meijer, Chris J L M


    Human papillomavirus (HPV) infections and HPV-associated penile lesions are frequently found in male sexual partners of women with cervical intraepithelial neoplasia (CIN). To determine the significance of these findings, we studied the prevalence of HPV and HPV associated penile lesions in a male hospital population with non-STD complaints. Penoscopy was performed after application of acetic acid to identify flat lesions, papular lesions, condylomata acuminata and pearly penile papules (PPPs). Presence of HPV DNA in penile scrapes was tested by GP5+6+ PCR. In case of HPV 16 positivity, viral loads were quantified using a LightCycler based real-time PCR method. Comparing the non-STD male hospital population (n = 118) with the male sexual partners of women with CIN (n = 238), flat penile lesions were found in 14% vs. 60% and penile HPV in 25% vs. 59% of the men, respectively. We found that the presence of penile HPV and, in case of HPV 16 positivity, higher viral loads were associated with the presence of flat penile lesions. Amongst the HPV-positive men, flat penile lesions were more common and larger in size in male sexual partners of women with CIN than in the non-STD hospital population. HPV infections and HPV-associated flat penile lesions are commonly found in the non-STD male population. However, these lesions are less frequently present and smaller in size than in male sexual partners of women with CIN. Higher viral loads in penile scrapes of male sexual partners of women with CIN are reflected by a higher prevalence of flat penile lesions and a larger size of these lesions.

  3. Temperature profile data from STD/CTD casts from the GYRE and other platforms from the NW Atlantic Ocean during the International Decade of Ocean Exploration / combination of USSR POLYGON project and US MODE (IDOE/POLYMODE) project, 20 May 1978 to 14 July 1978 (NODC Accession 8600032) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature and salinity profile data were collected using STD/CTD casts from GYRE and other platforms in the NW Atlantic Ocean from May 20, 1978 to July 14, 1978....

  4. Temperature profile data from STD/CTD casts from the OCEANUS from the Atlantic Ocean during the International Decade of Ocean Exploration / combination of USSR POLYGON project and US MODE (IDOE/POLYMODE) project, 06 June 1978 to 22 June 1978 (NODC Accession 8200056) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature, depth, salinity, and sigma-T data were collected using STD/CTD casts from OCEANUS in the Atlantic Ocean from June 6, 1978 to June 22, 1978. Data were...

  5. Temperature profile data from STD/CTD casts from the KNORR from a world-wide distribution during the International Decade of Ocean Exploration / Geochemical Ocean Section Study (IDOE/GEOSECS) project, 24 July 1972 - 09 June 1974 (NODC Accession 8200010) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature and salinity profile data were collected using STD/CTD casts from KNORR in a world-wide distribution from July 24, 1972 to June 9, 1974. Data were...

  6. Temperature profile data from STD/CTD casts from the KNORR from the Atlantic Ocean during the International Decade of Ocean Exploration / combination of USSR POLYGON project and US MODE (IDOE/POLYMODE) project, 1976-10-03 to 1976-10-19 (NODC Accession 7800010) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature and conductivity profile data were collected using STD/CTD casts from KNORR in the Atlantic Ocean from October 3, 1976 to October 19, 1976. Data were...

  7. Salinity profile data from STD/CTD casts from the ACONA and other platforms from the Atlantic Ocean during the International Decade of Ocean Exploration / North Pacific Experiment (IDOE/NORPAX) project, 20 October to 06 November 1976 (NODC Accession 7800604) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Salinity profile data were collected using STD/CTD casts from ACONA and other platforms in the Pacific Ocean from October 20, 1976 to November 6, 1976. Data were...

  8. Temperature profile data from STD/CTDs cast from the GYRE and other platforms from the Atlantic Ocean during the INTERNATIONAL DECADE OF OCEAN EXPLORATION / North Pacific Experiment (IDOE/NORPAX) project, 07 February 1979 to 14 June 1980 (NODC Accession 8200065) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature and salinity profile data were collected using STD/CTD casts from GYRE and other platforms in the Pacific Ocean from February 7, 1979 to June 14, 1980....

  9. Temperature profiles from STD casts from the Spanish Sahara from NOAA Ship OCEANOGRAPHER as part of the International Decade of Ocean Exploration / Coastal Upwelling Ecosystems Analysis (IDOE/CUEA) from 1974-03-08 to 1974-05-01 (NODC Accession 9800112) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from STD casts off the Spanish Sahara from NOAA Ship OCEANOGRAPHER from 08 March 1974 to 01 May 1974. Data were collected by the...

  10. Temperature profile data from STD/CTD casts from the FLIP and other platforms from the Pacific Ocean during the International Decade of Ocean Exploration / North Pacific Experiment (IDOE/NORPAX) project, 30 January to 1974-02-14 (NODC Accession 8100433) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature, sigma-T and salinity profile data were collected using STD/CTD casts from FLIP and other platforms in the Pacific Ocean from January 30, 1974 to...

  11. Temperature profile data from STD/CTD casts from the KANA KEOKI and other platforms from the Atlantic Ocean during the International Decade of Ocean Exploration / North Pacific Experiment (IDOE/NORPAX) project, 1977-11-10 to 1978-02-14 (NODC Accession 8100432) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature and salinity profile data were collected using STD/CTD casts from KANA KEOKI and other platforms in the Pacific Ocean from November 10, 1977 to February...

  12. Conhecimento sobre DST/AIDS por estudantes adolescentes Conocimiento sobre DST/SIDA por estudiantes adolecentes Knowledge of STD/AIDS among adolescent students

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    José Roberto da Silva Brêtas


    ; 75% femenino y 52% masculino citaron la televisión como fuente para obtención de informaciones; en cuanto al conocimiento de las EST (enfermedades sexualmente transmisibles los jóvenes demostraron tener poca información; en relación a la cura de las EST, 57% femenino y 71% masculino refirieron no tener conocimiento, siendo que 5% femenino y 6% masculino pensaban que el SIDA tiene cura. De forma general, pudimos concluir que las jóvenes estaban mejor informadas que los jóvenes.This study aims to analyze the degree of knowledge adolescents have on STD/AIDS prevention, transmission, signs, and symptoms, and to contribute with the elaboration of educational actions in the University Extension Program called Corporality and Health Promotion. The research counted on 1,087 adolescents (40% females, 60% males and was carried out in three elementary and high schools located in the municipality of Embu. A structured, multiple choice questionnaire was applied. Data indicated the achievement of the following results: as per the prevention, 92% of girls and 78% of boys referred to the use of condoms, while 42% of girls and 43% of boys affirmed to wash their genitalia after the sexual relation; 75% females and 52% males quoted television as their source of information. As per the knowledge of STD, girls and boys indicated not to have much information on the issue. Regarding STD healing programs, 57% females and 71% males affirmed not to have any knowledge on the issue; 5% of girls and 6% of boys thought AIDS to be curable. In a general perspective, we can conclude that girls were more familiar with the study's issues than boys.

  13. HPV vaccine implementation in STD clinics--STD Surveillance Network. (United States)

    Meites, Elissa; Llata, Eloisa; Hariri, Susan; Zenilman, Jonathan; Longfellow, Lisa; Schwebke, Jane; Tabidze, Irina; Mettenbrink, Christie; Jenkins, Heidi; Guerry, Sarah; Pathela, Preeti; Asbel, Lenore; Stover, Jeffrey A; Bernstein, Kyle; Kerani, Roxanne P; Dunne, Eileen F; Markowitz, Lauri E


    We surveyed selected public sexually transmitted disease clinics in the United States regarding human papillomavirus vaccine availability, target populations, funding sources, and barriers. Although nearly all had experience offering other vaccines, only 7 of 42 clinics (17%) offered human papillomavirus vaccine. Vaccine cost, staff time, and follow-up issues were commonly reported barriers.

  14. Structure and Dynamic Properties of a Ti-Binding Peptide Bound to TiO2 Nanoparticles As Accessed by (1)H NMR Spectroscopy. (United States)

    Suzuki, Yu; Shindo, Heisaburo; Asakura, Tetsuo


    Saturation transfer difference (STD) NMR spectroscopy is a powerful method for detecting and characterizing ligand-receptor interactions. In this study, the STD method was used to characterize the interactions of a Ti-binding peptide (TBP:RKLPDA) with TiO2 nanoparticles. The water peak in the NMR spectrum was selectively saturated, and the STD amplitudes for TBP were observed in the presence of TiO2, demonstrating that the side chains of the N-terminal residues Arg1 and Lys2 exhibit the strongest saturation transfer effect from water molecules; i.e., the two N-terminal residues are in contact with the TiO2 surface. The relaxation rate in the rotating frame, R1ρ, was observed to be high at the N-terminal residues; R1ρ decelerated toward the C-terminus, indicating that the N-terminal residues serve as anchors on the TiO2 surface and that the TBP motion bound to TiO2 particles is modeled as a wobble-in-cone with a fairly flexible C-terminus. The dissociation constant Kd of the TBP-TiO2 nanoparticle complex was 4.9 ± 1.8 mM, as estimated from the STD experiments and R1ρ measurements. The combination of these results and the negative zeta potential of the TiO2 surface validate that both the positively charged guanidyl group of Arg1 and amino group of Lys2 play key roles in interaction with the TiO2 surface by electrostatic force.

  15. PCR for detection of Chlamydia trachomatis in endocervical, urethral, rectal, and pharyngeal swab samples obtained from patients attending an STD clinic. (United States)

    Ostergaard, L; Agner, T; Krarup, E; Johansen, U B; Weismann, K; Gutschik, E


    OBJECTIVE: To investigate, by use of the Amplicor PCR in a routine setting, the recovery rate of Chlamydia trachomatis in ano-rectal and pharyngeal swab samples obtained from males and females attending an STD clinic in relation to sexual practices, symptoms, and signs. DESIGN: Data regarding sexual practices, and symptoms and signs related to the rectum and pharynx, were obtained from 196 females and 208 males, including 31 homosexuals and eight bisexuals. Swab samples were obtained from the urethra, rectum, and pharynx from all the patients. An additional endocervical swab sample was obtained from the females. METHODS: All samples were analysed by the Amplicor PCR (Roche). SETTING: Rudolph Bergh's Hospital, a clinic for sexually transmitted diseases situated in the centre of Copenhagen, Denmark. RESULTS: The overall prevalence of urogenital C trachomatis infection was 9.2% (37/404). The specificity of the Amplicor PCR was 100% for both ano-rectal and pharyngeal swab samples. In females three (13%) of the 23 infections were detected only by testing an ano-rectal or throat swab sample. In homosexual males two (67%) of three infections were detected only by the anorectal swab sample. Ano-rectal intercourse without use of condom was reported by 44% of females and by 52% of homosexual males. Fellatio without condom use was reported by 91% of females, and 80% of heterosexual males practised cunnilingus. Pharyngeal infection, however, occurred only in females, and the presence of pharyngeal symptoms or signs seemed predictive for pharyngeal C trachomatis infection, for which the time of incubation or colonisation exceeded 3 months. The presence of ano-rectal signs or symptoms was not predictive for an ano-rectal C trachomatis infection. CONCLUSION: The Amplicor PCR can be used on ano-rectal and pharyngeal swab samples. Ano-rectal swab samples should be obtained in females and homosexual males at high risk of being infected. Pharyngeal samples should be taken in females

  16. Forum: challenges in STD/AIDS prevention in Portuguese-speaking African countries: contributions from social research and from a gender approach: Introduction Fórum: desafios da prevenção das DST/AIDS em países africanos de língua oficial portuguesa: contribuições da pesquisa social e do recorte de gênero: Introdução

    Directory of Open Access Journals (Sweden)

    Simone Monteiro


    Full Text Available This forum on the challenges of preventing STD/AIDS in Portuguese-speaking African countries contains three articles and a postscript. The first paper reviews academic production on the topic from the fields of the social sciences and of health, with special attention on how local cultural and socioeconomic factors impact the dynamics of the epidemic. Based on an ethnographic study of a region in southern Mozambique, the second paper analyzes the notion of 'tradition' within the context of Mozambique and how it affects perceptions of the local population's vulnerability to STD/AIDS. The third and final article discusses common ground and differences between government and civil society in gender approaches by community HIV/AIDS projects in Mozambique. Their observations suggest that important mistakes have been made in STD/AIDS prevention discourse and initiatives in African countries because the unique features of local development models and cultural systems have not been taken into account.Esta introdução apresenta o Fórum sobre os desafios da prevenção às DST/AIDS em países africanos de língua oficial portuguesa, constituído por três artigos e um posfácio. O primeiro trabalho traz uma revisão da produção acadêmica no campo das ciências sociais e da saúde sobre o tema, focalizando as implicações dos fatores culturais e sócio-econômicos locais para a dinâmica da epidemia. A partir de um estudo etnográfico numa região do sul de Moçambique, o segundo texto analisa a noção de "tradição" no contexto moçambicano e suas conseqüências para a percepção da vulnerabilidade às DST/AIDS da população local. O terceiro artigo discute pontos de aproximação e de desencontro entre o governo e a sociedade civil na abordagem de gênero de projetos comunitários de enfrentamento do HIV/AIDS em Moçambique. As reflexões revelam que os discursos e ações de prevenção das DST/AIDS em países africanos apresentam equ

  17. Higher prevalence of sexual transmitted diseases and correlates of genital warts among heterosexual males attending sexually transmitted infection clinics (MSCs in Jiangmen, China: implication for the up-taking of STD related service.

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    Shujie Huang

    Full Text Available Increasing burden of STDs is one of China's major public health concerns. However, only a limited number of studies have ever investigated the prevalence of these STDs, particular for genital warts and its correlates among heterosexual males attending STD clinics in China. In order to fill this gap, we conducted a cross-sectional study among MSCs in Jiangmen, China, between the years of 2009 and 2010.The eligible participants were recruited from several STD-clinics in public hospitals. We collected demographic information and behaviors of the participants. After HIV and syphilis testing, we further checked whether the participants had genital warts and genital herpes. In addition, urine samples were collected from part of the participants for CT and NG testing.Of the 533 eligible participants, over three-fifths were aged 35 or below, nearly three quarters had no college degree, over three-fifths were residence of Jiangmen. The prevalence of HIV, syphilis, genital warts, genital herpes, CT and NG were 0.19%, 7.50%, 7.32%, 5.25%, 9.73% and 6.19%, respectively. Living with family members (versus living alone, no STD-related service in past year, experiencing STDs related symptoms in past year, and sex with FSWs in last three months were positively associated with genital warts, with adjusted ORs of 5.54 (95% CI 1.94-15.81, 2.26 (95% CI 1.08-4.74, 1.99 (95% CI 1.00-3.99 and 2.01 (95% CI 1.00-4.04, respectively.Our study indicates that the prevalence of STDs among MSCs in Jiangmen was high, which may further spread HIV among MSCs. Targeted interventions that focused on STDs related services uptake should be implemented urgently.

  18. Detecção de Doenças Sexualmente Transmissíveis em Clínica de Planejamento Familiar da Rede Pública no Brasil STD Screening in a Public Family Planning Clinic in Brazil

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    José Santiago de Codes


    mulheres infectadas não serão identificadas ou tratadas. Considerando-se a alta sensibilidade e especificidade da nova tecnologia disponível para o rastreamento da infecção por clamídia, gonorréia e infecção por HIV, e a facilidade de se coletarem espécimes de urina para o diagnóstico, mais esforços devem ser dirigidos para a vigilância das populações de risco, para que a prática clínica corrente possa refletir o risco verdadeiro das populações servidas.Purpose: to analyze the prevalence of gonorrhea, Chlamydia, syphilis and HIV among patients attending a family planning clinic regarding presence of STD symptoms and risk behaviors. Methods: women between the ages of 18 and 30 years who attended a public family planning clinic in Brazil were tested for gonorrhea and Chlamydia using the urine-based DNA amplification test (LCR, Abbott, and a blood test for syphilis (VDRL and HIV. All participants were asked questions about their health care seeking behavior, the presence of STD symptoms, and about the STD risk behaviors. Results: Chlamydia was found in 11.4%, syphilis in 2%, gonorrhea in 0.5% and HIV was confirmed positive in 3%. Approximately 61% of the women who were infected with Chlamydia had no symptoms. Women who never used condoms had much higher risks for STD than women who used them always or most of the time. Although not statistically significant, there was a trend for women who never used any contraceptive to have a higher risk for STD than women who used some method of contraception (p=0.09. However, when examining separately each contraceptive, none of them alone offered protection against STD. Very few women reported problems related to the use of alcohol or illegal drugs. But among those who did report such use, the risk for STD was very high, particularly regarding marijuana use. Conclusions: the most significant findings in our study were the high STD rates among a population of women generally reporting low-risk health behaviors. Based

  19. Limites do trabalho multiprofissional: estudo de caso dos centros de referência para DST/Aids Limitations of multiprofessional work: a case study of STD/AIDS reference centers

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    Neide Emy Kurokawa e Silva


    Full Text Available OBJETIVO: Compreender as possibilidades e os limites da articulação dos processos de trabalho desenvolvidos por agentes com diferentes formações para otimizar a integração e melhorar a qualidade da assistência aos pacientes com HIV/Aids. MÉTODOS: Estudo qualitativo sobre o trabalho multiprofissional em cinco centros de referência para DST/Aids do Município de São Paulo. Foram realizadas entrevistas semi-estruturadas com 26 profissionais de diferentes formações, enfocando suas relações no modo de organização da assistência prestada nesses serviços. RESULTADOS: Houve diferenças significativas do alcance da integração multiprofissional e das possibilidades de enriquecimento da assistência prestada, de acordo com as circunstâncias em que o trabalho interdisciplinar é posto em ação. CONCLUSÕES: Quando a equipe consegue trabalhar com demandas antevistas, isto é, com a formulação, por um conjunto de profissionais, de projetos assistenciais, antecipando demandas a partir de situações concretas da prática, criam-se condições favoráveis a um trabalho mais efetivamente integrado da equipe multiprofissional. Essa integração favorece intervenções que permitem um diálogo mais rico entre a aplicação do tratamento medicamentoso e outras dimensões relevantes do cuidado referentes às vivências sociais, psicológicas e emocionais dos pacientes.OBJECTIVE: To understand the possibilities and limitations of developing coordinated work among professionals of different background in order to promote work collaboration and improve the quality of care of HIV/AIDS patients. METHODS: A qualitative study on multiprofessional work was carried out in five STD/AIDS reference centers in the city of São Paulo, Brazil. Semi-structured interviews were applied to 26 professionals from different background, focusing on how they position their practices in a multiprofessional setting. RESULTS: Significant differences were observed as to

  20. Evaluation of an HIV/STD sexual risk-reduction intervention for pregnant African American adolescents attending a prenatal clinic in an urban public hospital: preliminary evidence of efficacy. (United States)

    DiClemente, R J; Wingood, G M; Rose, E; Sales, J M; Crosby, R A


    To evaluate an intervention to reduce HIV/STD-associated behaviors and enhance psychosocial mediators for pregnant African-American adolescents. A randomized controlled trial. Participants completed baseline and follow-up assessments. An urban public hospital in the Southeastern U.S. Pregnant African-American adolescents (N=170), 14-20 years of age, attending a prenatal clinic. Intervention participants received two 4-hr group sessions enhancing self-concept and self-worth, HIV/STD prevention skills, and safer sex practices. Participants in the comparison condition received a 2-hr session on healthy nutrition. Consistent condom use. Intervention participants reported greater condom use at last intercourse (adjusted odds ratio=3.9, P=0.05) and consistent condom use (AOR=7.9, P=0.05), higher sexual communication frequency, enhanced ethnic pride, higher self-efficacy to refuse risky sex, and were less likely to fear abandonment as a result of negotiating safer sex. Interventions for pregnant African-American adolescents can enhance condom use and psychosocial mediators. Copyright 2010 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

  1. High-Energy, Multi-Octave-Spanning Mid-IR Sources via Adiabatic Difference Frequency Generation (United States)


    ABSTRACT The creation of energetic , arbitrarily shapeable, multi-octave-spanning, coherent sources of short-wave, mid-wave, and long-wave mid-IR...plan. We have evaluated a brand-new concept in nonlinear optics, adiabatic difference frequency generation (ADFG) for the efficient transfer of...generation: limited bandwidth and limited conversion efficiency . 15. SUBJECT TERMS Standard Form 298 (Rev. 8/98) Prescribed by ANSI Std. Z39.18 Page 1 of

  2. Evaluation of STD/AIDS prevention programs: a review of approaches and methodologies Avaliação de programas de prevenção de DST/AIDS: revendo abordagens e metodologias

    Directory of Open Access Journals (Sweden)

    Marly Marques da Cruz


    Full Text Available The article presents a review of approaches and methodologies in the evaluation of STD/AIDS prevention programs, searching for theoretical and methodological support for the institutionalization of evaluation and decision-making. The review included the MEDLINE, SciELO, and ISI Web of Science databases and other sources like textbooks and congress abstracts from 1990 to 2005, with the key words: "evaluation", "programs", "prevention", "STD/AIDS", and similar terms. The papers showed a predominance of quantitative outcome or impact evaluative studies with an experimental or quasi-experimental design. The main use of evaluation is accountability, although knowledge output and program improvement were also identified in the studies. Only a few evaluative studies contemplate process evaluation and its relationship to the contexts. The review aimed to contribute to the debate on STD/AIDS, which requires more effective, consistent, and sustainable decisions in the field of prevention.O artigo apresenta uma revisão de abordagens e metodologias sobre avaliação de programas de prevenção de DST/AIDS, buscando um aporte teórico-metodológico que subsidie a institucionalização da avaliação e a tomada de decisão. A revisão foi realizada nas bases de dados do MEDLINE, SciELO, ISI Web of Science e outras fontes, tais como livros, textos e resumos apresentados em congressos, no período de 1990 a 2005, das palavras-chave: "avaliação", "programas", "prevenção", "DST/AIDS" e termos similares. Nos artigos levantados há uma predominância de estudos avaliativos quantitativos de resultado ou de impacto, do tipo experimental ou quase-experimental. O principal uso da avaliação é o da prestação de contas, embora a produção do conhecimento e a melhoria do programa possam ser identificados nos estudos examinados. Poucos são os estudos avaliativos que contemplam a avaliação de processo e discutem a sua relação com os contextos. Pretendeu

  3. Structural basis for norovirus inhibition and fucose mimicry by citrate. (United States)

    Hansman, Grant S; Shahzad-Ul-Hussan, Syed; McLellan, Jason S; Chuang, Gwo-Yu; Georgiev, Ivelin; Shimoike, Takashi; Katayama, Kazuhiko; Bewley, Carole A; Kwong, Peter D


    Human noroviruses bind with their capsid-protruding domains to histo-blood-group antigens (HBGAs), an interaction thought to direct their entry into cells. Although human noroviruses are the major cause of gastroenteritis outbreaks, development of antivirals has been lacking, mainly because human noroviruses cannot be cultivated. Here we use X-ray crystallography and saturation transfer difference nuclear magnetic resonance (STD NMR) to analyze the interaction of citrate with genogroup II (GII) noroviruses. Crystals of citrate in complex with the protruding domain from norovirus GII.10 Vietnam026 diffracted to 1.4 Å and showed a single citrate bound at the site of HBGA interaction. The citrate interaction was coordinated with a set of capsid interactions almost identical to that involved in recognizing the terminal HBGA fucose, the saccharide which forms the primary conserved interaction between HBGAs and GII noroviruses. Citrate and a water molecule formed a ring-like structure that mimicked the pyranoside ring of fucose. STD NMR showed the protruding domain to have weak affinity for citrate (460 μM). This affinity, however, was similar to the affinities of the protruding domain for fucose (460 μM) and H type 2 trisaccharide (390 μM), an HBGA shown previously to be specifically recognized by human noroviruses. Importantly, competition STD NMR showed that citrate could compete with HBGA for norovirus binding. Together, the results suggest that citrate and other glycomimetics have the potential to block human noroviruses from binding to HBGAs.

  4. Structural Basis for Norovirus Inhibition and Fucose Mimicry by Citrate

    Energy Technology Data Exchange (ETDEWEB)

    Hansman, Grant S.; Shahzad-ul-Hussan, Syed; McLellan, Jason S.; Chuang, Gwo-Yu; Georgiev, Ivelin; Shimoike, Takashi; Katayama, Kazuhiko; Bewley, Carole A.; Kwong, Peter D. (NIAID)


    Human noroviruses bind with their capsid-protruding domains to histo-blood-group antigens (HBGAs), an interaction thought to direct their entry into cells. Although human noroviruses are the major cause of gastroenteritis outbreaks, development of antivirals has been lacking, mainly because human noroviruses cannot be cultivated. Here we use X-ray crystallography and saturation transfer difference nuclear magnetic resonance (STD NMR) to analyze the interaction of citrate with genogroup II (GII) noroviruses. Crystals of citrate in complex with the protruding domain from norovirus GII.10 Vietnam026 diffracted to 1.4 {angstrom} and showed a single citrate bound at the site of HBGA interaction. The citrate interaction was coordinated with a set of capsid interactions almost identical to that involved in recognizing the terminal HBGA fucose, the saccharide which forms the primary conserved interaction between HBGAs and GII noroviruses. Citrate and a water molecule formed a ring-like structure that mimicked the pyranoside ring of fucose. STD NMR showed the protruding domain to have weak affinity for citrate (460 {mu}M). This affinity, however, was similar to the affinities of the protruding domain for fucose (460 {mu}M) and H type 2 trisaccharide (390 {mu}M), an HBGA shown previously to be specifically recognized by human noroviruses. Importantly, competition STD NMR showed that citrate could compete with HBGA for norovirus binding. Together, the results suggest that citrate and other glycomimetics have the potential to block human noroviruses from binding to HBGAs.

  5. Influence of carbohydrates on the interaction of procyanidin B3 with trypsin. (United States)

    Gonçalves, Rui; Mateus, Nuno; De Freitas, Victor


    The biological properties of procyanidins, in particular their inhibition of digestive enzymes, have received much attention in the past few years. Dietary carbohydrates are an environmental factor that is known to affect the interaction of procyanidins with proteins. This work aimed at understanding the effect of ionic food carbohydrates (polygalacturonic acid, arabic gum, pectin, and xanthan gum) on the interaction between procyanidins and trypsin. Physical-chemical techniques such as saturation transfer difference-NMR (STD-NMR) spectroscopy, fluorescence quenching, and nephelometry were used to evaluate the interaction process. Using STD-NMR, it was possible to identify the binding of procyanidin B3 to trypsin. The tested carbohydrates prevented the association of procyanidin B3 and trypsin by a competition mechanism in which the ionic character of carbohydrates and their ability to encapsulate procyanidins seem crucial leading to a reduction in STD signal and light scattering and to a recovery of the proteins intrinsic fluorescence. On the basis of these results, it was possible to grade the carbohydrates in their aggregation inhibition ability: XG > PA > AG ≫ PC. These effects may be relevant since the coingestion of procyanidins and ionic carbohydrates are frequent and furthermore since these might negatively affect the antinutritional properties ascribed to procyanidins in the past.

  6. Autopercepção de vulnerabilidade às doenças sexualmente transmissíveis e Aids em mulheres Self-assessment of STD/AIDS vulnerability among women, Brazil

    Directory of Open Access Journals (Sweden)

    Mariângela F Silveira


    Full Text Available OBJETIVO: Investigar comportamentos de risco e autopercepção de vulnerabilidade às doenças sexualmente transmissíveis (DST e à Síndrome de imunodeficiência adquirida (Aids em mulheres. MÉTODOS: Dos 281 setores censitários existentes na cidade de Pelotas, RS, foram selecionados 48 a partir de amostragem sistemática. Foi entrevistada uma amostra de 1.543 mulheres, de 15 a 49 anos, por meio de questionário composto de três partes (informações socioeconômicas, perguntas aplicadas em entrevista, questionário auto-aplicado. Para tabulação dos dados, foi utilizado o programa Epi-Info, versão 6.0. Para análise estatística dos dados foram usados o teste de Kappa e a razão de odds. RESULTADOS: Na amostra, 64% das mulheres achavam impossível ou quase impossível adquirir DST/Aids. Os principais comportamentos de risco foram o não uso de preservativo na última relação antes do depoimento (72%; início das relações sexuais com menos de 18 anos (47%; uso de álcool ou drogas pelo parceiro (14% ou pela mulher (7% antes da última relação; dois ou mais parceiros nos três meses que antecederam o depoimento (7% e sexo anal na última relação (3%; 44% das mulheres apresentaram dois ou mais comportamentos de risco. A sensibilidade da autopercepção, usando como padrão o escore de risco igual ou superior a dois, foi de 41 %. Sua especificidade de 67%. CONCLUSÕES: A autopercepção de vulnerabilidade não é um bom indicador, pois as mulheres não identificam corretamente seu nível de risco.OBJECTIVE: To investigate risk behaviors and self-assessment of the vulnerability to sexually transmitted diseases (STD and acquired immunodeficiency syndrome (AIDS among women. METHODS: A systematic sample including 48 of 281 census tracts in the urban area of Pelotas, Brazil, was selected. There were interviewed 1,543 women, aged between 15 and 49 years, who had ever been sexually active. Risk behaviors were assessed using a confidential

  7. A violência nas relações afetivas dificulta a prevenção de DST/AIDS? Does violence in the emotional relationships make STD/AIDS prevention more difficult?

    Directory of Open Access Journals (Sweden)

    Maria Helena Ruzany


    Full Text Available OBJETIVOS: identificar a ocorrência de situações de violência no cotidiano de adolescentes e jovens de comunidades de baixa renda; pesquisar a relação entre uso de drogas e comportamentos de risco de DST/AIDS; e verificar se a violência nas relações afetivas entre adolescentes e jovens dificulta a prevenção de DST/AIDS. MÉTODOS: estudo epidemiológico com adolescentes e jovens de dois bairros da cidade do Rio de Janeiro, a partir dos dados obtidos de um questionário estruturado que versava sobre perfil da clientela, informações sobre a família, uso de drogas, situações de violência do cotidiano, experiência sexual, entre outras. Para o presente artigo, somente as variáveis que particularizavam agressividade, uso de drogas, comportamentos sexuais de risco e violência nas relações afetivas foram analisadas. Em particular, destacou-se a associação da variável "eu usei camisinha na última relação sexual" com as questões que indicavam ou não atitudes violentas nas relações afetivas. RESULTADOS: participaram 1.041 indivíduos na faixa etária entre 14 e 22 anos, sendo 53,6% do sexo feminino. Entre os resultados mais relevantes, observou-se uma relação estatisticamente significativa entre o não uso de preservativo (pOBJECTIVES: to identify violent situations in the daily life of adolescents and young people of low-income communities; to establish a relation between the use of drugs and STD/AIDS risk behavior; and to verify if violence in the emotional relationships between adolescents and young people make the STD/AIDS prevention more difficult. METHOD: epidemiological study with adolescents and young people of two neighborhoods in the city of Rio de Janeiro, based on the results obtained from a structured questionnaire that dealt with subjects' profile, information about the family, use of drugs, daily violent situations, sexual experience, among others. For the present article, only the variables that dealt with

  8. DOE 5700.6C, 10CFR830.120, DOE-ER-STD-6001-92, and Covey-based TQM: A historical perspective on current issues in research environments

    Energy Technology Data Exchange (ETDEWEB)

    Bodnarczuk, M


    Three years ago there were no standards or published guidelines for quality in research environments. Today, one standard has been published, and three guidelines documents are in final draft form and about to be published. In this paper, I describe the events that led to the writing of DOE 5700.6C, 10CFR830.120, and DOE-ER-STD-6001-92, focusing on the cultural barriers that arose (largely in the community of quality assurance professionals) during this process. I go on to describe why I believe that implementing DOE 5700.6C and 10CFR830.120 must be pushed even further toward an approach that embodies the Malcolm Baldrige National Quality Award and why even this is not far enough. The reason is because the most crucial aspect of successfully implementing a quality initiative is to base it on a cohesive, unified foundation of organizational and individual values and beliefs. Stephen Covey`s 7 Habits of Highly Effective People and Principle Centered Leadership provide such a foundations.

  9. Complete NMR assignment and conformational analysis of 17-α-ethinylestradiol by using RDCs obtained in grafted graphene oxide. (United States)

    França, José A A; Navarro-Vázquez, Armando; Lei, Xinxiang; Sun, Han; Griesinger, Christian; Hallwass, Fernando


    The 1 H and 13 C NMR spectra of 17-α-ethinylestradiol (EE2), a well-known contraceptive, including diastereotopic methylene groups, were fully assigned with the help of residual dipolar couplings (RDC) measured in the recently developed grafted graphene oxide orienting medium. RDC analysis, which included all 1 D CH couplings and the long-range 2 D CH 1 H-C≡ 13 C coupling, also pointed to the presence of a minor conformation arising from pseudo-rotation of the steroid B ring. Saturation-transfer difference (STD) measurements revealed that the most likely interaction between EE2 and orienting medium occurred on the C and D ring. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  10. Supramolecular Amino Acid Based Hydrogels: Probing the Contribution of Additive Molecules using NMR Spectroscopy (United States)

    Ramalhete, Susana M.; Nartowski, Karol P.; Sarathchandra, Nichola; Foster, Jamie S.; Round, Andrew N.; Angulo, Jesús


    Abstract Supramolecular hydrogels are composed of self‐assembled solid networks that restrict the flow of water. l‐Phenylalanine is the smallest molecule reported to date to form gel networks in water, and it is of particular interest due to its crystalline gel state. Single and multi‐component hydrogels of l‐phenylalanine are used herein as model materials to develop an NMR‐based analytical approach to gain insight into the mechanisms of supramolecular gelation. Structure and composition of the gel fibres were probed using PXRD, solid‐state NMR experiments and microscopic techniques. Solution‐state NMR studies probed the properties of free gelator molecules in an equilibrium with bound molecules. The dynamics of exchange at the gel/solution interfaces was investigated further using high‐resolution magic angle spinning (HR‐MAS) and saturation transfer difference (STD) NMR experiments. This approach allowed the identification of which additive molecules contributed in modifying the material properties. PMID:28401991

  11. A High-Resolution Magic Angle Spinning NMR Study of the Enantiodiscrimination of 3,4-Methylenedioxymethamphetamine (MDMA by an Immobilized Polysaccharide-Based Chiral Phase.

    Directory of Open Access Journals (Sweden)

    Juliana C Barreiro

    Full Text Available This paper reports the investigation of the chiral interaction between 3,4-methylenedioxy-methamphetamine (MDMA enantiomers and an immobilized polysaccharide-based chiral phase. For that, suspended-state high-resolution magic angle spinning nuclear magnetic resonance spectroscopy (1H HR-MAS NMR was used. 1H HR-MAS longitudinal relaxation time and Saturation Transfer Difference (STD NMR titration experiments were carried out yielding information at the molecular level of the transient diastereoisomeric complexes of MDMA enantiomers and the chiral stationary phase. The interaction of the enantiomers takes place through the aromatic moiety of MDMA and the aromatic group of the chiral selector by π-π stacking for both enantiomers; however, a stronger interaction was observed for the (R-enantiomer, which is the second one to elute at the chromatographic conditions.

  12. Predictors and moderators of outcomes of HIV/STD sex risk reduction interventions in substance abuse treatment programs: a pooled analysis of two randomized controlled trials. (United States)

    Crits-Christoph, Paul; Gallop, Robert; Sadicario, Jaclyn S; Markell, Hannah M; Calsyn, Donald A; Tang, Wan; He, Hua; Tu, Xin; Woody, George


    The objective of the current study was to examine predictors and moderators of response to two HIV sexual risk interventions of different content and duration for individuals in substance abuse treatment programs. Participants were recruited from community drug treatment programs participating in the National Institute on Drug Abuse Clinical Trials Network (CTN). Data were pooled from two parallel randomized controlled CTN studies (one with men and one with women) each examining the impact of a multi-session motivational and skills training program, in comparison to a single-session HIV education intervention, on the degree of reduction in unprotected sex from baseline to 3- and 6- month follow-ups. The findings were analyzed using a zero-inflated negative binomial (ZINB) model. Severity of drug use (p abuse have more USOs). Monogamous relationship status (p sex under the influence of drugs/alcohol (p abuse of primary drug (p < .05 in non-zero portion of model), and Hispanic ethnicity (p < .01 in the zero portion, p < .05 in the non-zero portion of model). These predictor and moderator findings point to ways in which patients may be selected for the different HIV sexual risk reduction interventions and suggest potential avenues for further development of the interventions for increasing their effectiveness within certain subgroups.

  13. Secondary syphilis in the oral cavity and the role of the dental surgeon in STD prevention, diagnosis and treatment: a case series study. (United States)

    Seibt, Creta Elisa; Munerato, Maria Cristina


    Syphilis is an infectious disease caused by the bacterium Treponema pallidum. Syphilis has three clinical stages and may present various oral manifestations, mainly at the secondary stage. The disease mimics other more common oral mucosa lesions, going undiagnosed and with no proper treatment. Despite the advancements in medicine toward prevention, diagnosis, and treatment syphilis remains a public health problem worldwide. In this sense, dental surgeons should be able to identify the most common manifestations of the disease in the oral cavity, pointing to the role of this professional in prevention and diagnosis. This study describes a case series of seven patients with secondary syphilis presenting different oral manifestations. Copyright © 2016 Elsevier Editora Ltda. All rights reserved.

  14. Detection of Incomplete Root Fractures in Endodontically Treated Teeth Using Different High-resolution Cone-beam Computed Tomographic Imaging Protocols. (United States)

    Wanderley, Victor Aquino; Neves, Frederico Sampaio; Nascimento, Monikelly Carmo Chagas; Monteiro, Gabriela Queiroz de Melo; Lobo, Natália Siqueira; Oliveira, Matheus Lima; Nascimento Neto, Joao Batista Sobrinho; Araujo, Luciane Farias


    The purpose of this study was to compare different high-resolution cone-beam computed tomographic (CBCT) imaging protocols in the diagnosis of incomplete root fractures of endodontically treated teeth. Twenty single-rooted human teeth were endodontically treated, and an incomplete root fracture was induced. The teeth were scanned with the CBCT unit PreXion 3D (Teracom, San Mateo, CA) operating at 2 different protocols: high resolution/standard (HI-STD) (19 seconds and 512 basis images) and high resolution/high density (HI-HI) (37 seconds and 1024 basis images). Three oral radiologists evaluated all images using multiplanar reconstructions. The diagnostic tests and the receiver operating characteristic (ROC) curve were calculated. The HI-STD and HI-HI protocols presented an accuracy of 0.90 and 0.93, respectively, and both protocols had a sensitivity of 0.97. The HI-HI protocol showed a higher positive predictive value and slightly higher areas under the ROC curve. Both high-resolution imaging protocols presented high accuracy in the detection of incomplete root fracture of endodontically teeth. Thus, the HI-STD protocol should be indicated this reduces the radiation dose. Copyright © 2017 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  15. Rapid tests for diagnosing syphilis: validation in an STD clinic in the Amazon Region, Brazil Testes rápidos para diagnóstico de sífilis: validação em clínica de DST na Região Amazônica, Brasil

    Directory of Open Access Journals (Sweden)

    Adele Schwartz Benzaken


    Full Text Available Correct, early diagnosis and treatment of syphilis are essential for its control. Traditional diagnostic tests depend on specialized equipment, installations, and human resources. In the search for quick, simple tests, a project was conducted on the validation and reproducibility of four different tests, previously assessed by WHO reference laboratories. The study also verified the operational characteristics and acceptance by patients and health professionals. Samples obtained at an STD clinic were from 541 and 248 patients with 51 and 52 positive results according to FTA-Abs (gold standard in studies 1 and 2, respectively. The sensitivity varied from 84 to 96%, specificity was greater than 98%, and PPV was > 90%. Reproducibility was > 97% and kappa index 0.94, comparing the results obtained by different health workers. The tests took less than 20 minutes to perform, and more than 90% of patients agreed to wait up to two hours for the results. The tests presented the necessary requirements for use in diagnosis of syphilis, thus providing an additional option for controlling this disease.O diagnóstico e o tratamento corretos e precoces da sífilis são essenciais para o seu controle. Os testes diagnósticos tradicionais dependem de equipamentos, instalações e recursos humanos especializados. Na busca de testes de execução simplificada e rápida, realizou-se projeto de validação e da reprodutibilidade de quatro diferentes testes anteriormente avaliados pelos laboratórios de referência da Organização Mundial da Saúde. Verificaram-se também as características operacionais e aceitabilidade dos pacientes e dos profissionais de saúde. As amostras obtidas numa clínica de DST constaram de 541 e 248 pacientes com 51 e 52 positivos no FTA-Abs (padrão ouro nos estudos 1 e 2, respectivamente. A sensibilidade variou entre 84 e 96%, especificidade superior a 98% e valor preditivo positivo > 90%. A reprodutibilidade foi superior a 97% e 0

  16. Recognition characteristics of monoclonal antibodies that are cross-reactive with gangliosides and lipooligosaccharide from Campylobacter jejuni strains associated with Guillain-Barré and Fisher syndromes. (United States)

    Houliston, R Scott; Yuki, Nobuhiro; Hirama, Tomoko; Khieu, Nam H; Brisson, Jean-Robert; Gilbert, Michel; Jarrell, Harold C


    The enteropathogen Campylobacter jejuni has the ability to synthesize glycan structures that are similar to mammalian gangliosides within the core component of its lipooligosaccharide (LOS). Exposure to ganglioside mimics in some individuals results in the production of autoantibodies that deleteriously attack nerve surface gangliosides, precipitating the onset of Guillain-Barré and Fisher syndromes (GBS and FS). We have characterized the interaction of four monoclonal antibodies (mAbs), established by sensitization of mice with LOS isolated from GBS- and FS-associated C. jejuni strains, with chemoenzymatically synthesized gangliooligosaccharides. Surface plasmon resonance (SPR) measurements demonstrate that three of the mAbs interact specifically with derivatives corresponding to their targeted gangliosides, with dissociation constants ranging from 10 to 20 microM. Antibody binding to the gangliooligosaccharides was probed by saturation transfer difference (STD) NMR spectroscopy. STD signals, resulting from antibody/oligosaccharide interaction, were observed for each of the four mAbs. In two cases, differential saturation transfer rates to oligosaccharide resonances enabled detailed epitope mapping. The binding of GD1a-S-Phe with GB1 is characterized by close association of the immunoglobulin with sites that are distributed over several residues of the oligosaccharide. This contrasts sharply with the profile observed for the binding of both GD3-S-Phe and GT1a-S-Phe with FS1. The close antigenic contacts in these ganglioside derivatives are confined to the N-acetylmannosaminyl portion of the terminal N-acetylneuraminic acid (NeuAc) residue of the disialosyl moiety. Our characterization of FS1 provides insight, at an atomic level, into how a single antigenic determinant presented by the LOS of C. jejuni can give rise to antibodies with binding promiscuity to [alphaNeuAc-(2-8)-alphaNeuAc]-bound epitopes and demonstrates why sera from FS patients have antibodies that

  17. STD Awareness PSA - College 2 (:30)

    Centers for Disease Control (CDC) Podcasts


    This PSA, targeted to college-aged youth and young adults, encourages listeners to get tested for STDs.  Created: 4/22/2010 by Centers for Disease Control and Prevention (CDC).   Date Released: 4/22/2010.

  18. STD Awareness PSA - College 1 (:30)

    Centers for Disease Control (CDC) Podcasts


    This PSA, targeted to college-aged youth and young adults, encourages listeners to get tested for STDs.  Created: 4/22/2010 by Centers for Disease Control and Prevention (CDC).   Date Released: 4/22/2010.

  19. STD Awareness PSA - Male Announcer 2 (:30)

    Centers for Disease Control (CDC) Podcasts


    This PSA encourages listeners to get tested for STDs. Target - Men who have sex with other men.  Created: 4/22/2010 by Centers for Disease Control and Prevention (CDC).   Date Released: 4/22/2010.

  20. STD Symptoms: Common STDs and Their Symptoms (United States)

    ... with an infected person's blood. Others, such as gonorrhea, can only be transmitted through sexual contact. Chlamydia ... between periods in women Testicular pain in men Gonorrhea is a bacterial infection of your genital tract. ...

  1. STD Testing: What's Right for You (United States)

    ... testing for specific sexually transmitted infections. Chlamydia and gonorrhea Get screened annually if: You're a sexually ... in sexual activity against your will Chlamydia and gonorrhea screening is done either through a urine test ...

  2. Sex-specific differences in mortality after high-titre measles immunization in rural Senegal. (United States)

    Aaby, P.; Samb, B.; Simondon, F.; Knudsen, K.; Seck, A. M.; Bennett, J.; Markowitz, L.; Rhodes, P.; Whittle, H.


    Administration of high-titre measles vaccine (Edmonston-Zagreb (EZ) at > 10(5) plaque-forming units (PFU) per dose) before the age of 9 months has been recommended in areas with high measles mortality before the routine age of immunization after 9 months. The study compares the long-term survival after high-titre measles immunization at 5 months of age with that following routine immunization with standard-titre vaccine at 10 months of age. At 5 months of age the high-titre group received Edmonston-Zagreb (EZ-HT, 5 months) or Schwarz (SW-HT, 5 months) at titres > 10(5) PFU per dose, while the standard-titre group received placebo at 5 months of age and < 10(4) PFU per dose of Schwarz vaccine at 10 months (SW-std, 10 months). All the children were followed up to at least 36 months of age. The mortality ratio (MR) for infants in the EZ-HT, 5 months and SW-HT, 5 months groups was 1.32 (P = 0.089) and 1.45 (P = 0.092), respectively, which did not differ significantly from that of recipients of the SW-std, 10 months. The higher MR among recipients of the high-titre vaccines was due to the significantly lower survival among females compared with the females who received SW-std vaccine (EZ-HT, 5 months MR = 1.76, P = 0.013; SW-HT, 5 months MR = 2.14, P = 0.017). For children aged 5-10 months the high-titre measles vaccine did not increase mortality relative to unvaccinated children who had received placebo. PMID:7955026

  3. Perceptions About Sex Related Myths And Misconceptions: Difference In Male And Female

    Directory of Open Access Journals (Sweden)

    Anupam Raizada


    Full Text Available Research problem: Perceptions about sex-re- iated myths and misconceptions.Objectives: To identify the difference in percep­tions of mates and females over sex-reiated myths and misconceptions.Study Design - Community based cross sectional study.Setting - Self-administered questionnaire study was un­dertaken in an urban area of Jhansi.Participants - Married couples with reproductive age wife.Sample size - 417 couples of the area.Study Variables-Sex-related myths and misconceptionsOutcome Variables - Masturbation, Penis-size and sexual performance, STD transmission. Intercourse with virgin and cure of STDs, Initiation of sexual act, Bleeding on first night.Statistical analysis - By chi - square test.Results: Response rate 63.8%. Only 8.6% females and 33.7% males knew correctly about masturbation. Males also knew better about route of STD infection (73.5% and about the fact that intercouse with a virgin cannot cure STDs (47.4%. Females, however, outnumber males on the question of relation between man's penis size and his sexual performance (70%, initiation of sexual act (58.6% and bleeding in females on first night of marriage (70%.Conclusion: Males and females had significantly different perceptions on sex related myths and misconceptions.Recommendations: Sex education campaigns should be designed and implemented to eliminate these age old sex related myths and misconceptions.

  4. Molecular Interaction Between Salivary Proteins and Food Tannins. (United States)

    Silva, Mafalda Santos; García-Estévez, Ignacio; Brandão, Elsa; Mateus, Nuno; de Freitas, Victor; Soares, Susana


    Polyphenols interaction with salivary proteins (SP) has been related with organoleptic features such as astringency. The aim of this work was to study the interaction between some human SP and tannins through two spectroscopic techniques, fluorescence quenching, and saturation transfer difference-nuclear magnetic resonance (STD-NMR). Generally, the results showed a significant interaction between SP and both condensed tannins and ellagitannins. Herein, STD-NMR proved to be a useful tool to map tannins' epitopes of binding, while fluorescence quenching allowed one to discriminate binding affinities. Ellagitannins showed the greatest binding constants values (KSV from 20.1 to 94.1 mM-1; KA from 0.7 to 8.3 mM-1) in comparison with procyanidins (KSV from 5.4 to 40.0 mM-1; KA from 1.1 to 2.7 mM-1). In fact, punicalagin was the tannin that demonstrated the highest affinity for all three SP. Regarding SP, P-B peptide was the one with higher affinity for ellagitannins. On the other hand, cystatins showed in general the lower KSV and KA values. In the case of condensed tannins, statherin was the SP with the highest affinity, contrasting with the other two SP. Altogether, these results are evidence that the distinct SP present in the oral cavity have different abilities to interact with food tannins class.

  5. Comparing binding modes of analogous fragments using NMR in fragment-based drug design: application to PRDX5.

    Directory of Open Access Journals (Sweden)

    Clémentine Aguirre

    Full Text Available Fragment-based drug design is one of the most promising approaches for discovering novel and potent inhibitors against therapeutic targets. The first step of the process consists of identifying fragments that bind the protein target. The determination of the fragment binding mode plays a major role in the selection of the fragment hits that will be processed into drug-like compounds. Comparing the binding modes of analogous fragments is a critical task, not only to identify specific interactions between the protein target and the fragment, but also to verify whether the binding mode is conserved or differs according to the fragment modification. While X-ray crystallography is the technique of choice, NMR methods are helpful when this fails. We show here how the ligand-observed saturation transfer difference (STD experiment and the protein-observed 15N-HSQC experiment, two popular NMR screening experiments, can be used to compare the binding modes of analogous fragments. We discuss the application and limitations of these approaches based on STD-epitope mapping, chemical shift perturbation (CSP calculation and comparative CSP sign analysis, using the human peroxiredoxin 5 as a protein model.

  6. "Tradition", person, gender, and STD/HIV/AIDS in southern Mozambique "Tradição", pessoa, gênero e DST/HIV/AIDS no Sul de Moçambique

    Directory of Open Access Journals (Sweden)

    Luiz Henrique Passador


    Full Text Available In southern Mozambique, the "traditional" notion of personhood is constructed through a process, as an outcome of diachronic and synchronic social relations that encompass kin and other peers, including spirits. Both person and body are thought of as elements traversed and determined by these relations, which include the gender relations whose complementarity finds expression in alliances and the production of descendants. In this system of agnatic kinship, descent is possible through women, who produce the male and female persons. Because of women's structural position, they may be suspected of fostering deconstruction of the person as well, with diseases providing the objective data that ground such a charge. To a certain degree, HIV/AIDS has been experienced in terms of this sociocultural arrangement, which defines disease as the result of action by social subjects that jeopardizes the person, placing women in the vulnerable position of being seen as the producers of disease. This has defined the ways in which people experience both the epidemic as well as STD/HIV/AIDS prevention and treatment messages and public policies.No Sul de Moçambique, a noção "tradicional" de pessoa constrói-se numa perspectiva processual, como fluxo de relações sociais diacrônicas e sincrônicas que congregam parentes e outros pares, inclusive os espíritos. Pessoa e corpo são pensados como elementos atravessados e determinados por essas relações, que congregam as relações de gênero em termos de complementaridade realizada nas alianças e produção da descendência. Num sistema de descendência local, é através das mulheres que a filiação e a descendência são possíveis, gerando a pessoa masculina e feminina. Essa posição estrutural as coloca sob suspeitas de promoção da desconstrução da pessoa, sendo as doenças percebidas como dados objetivos que apontam para tal ação. Em certa medida, o HIV/AIDS tem sido experimentado nos termos dessa

  7. Hesperidin interaction to collagen detected by physico-chemical techniques. (United States)

    Hiraishi, Noriko; Maruno, Takahiro; Tochio, Naoya; Sono, Ryohei; Otsuki, Masayuki; Takatsuka, Tsutomu; Tagami, Junji; Kobayashi, Yuji


    Dentin collagen can be modified by some plant-derived flavonoids to improve properties of dentin organic matrix. Hesperidin (HPN), a hesperetin-7-O-rutinoside flavonoid, has a potential of dentin modification for being based on evidence that a treatment with HPN may resist collagenase degradation and arrest demineralization of human dentin. In this study, biophysical and molecular-level information on the interaction of HPN and collagen was investigated. HPN is extracted from citrus fruits. Sample collagenous solution was prepared using atelocollagen (ATCL) as a triple-helical peptide model. We have performed circular dichroism spectroscopic analysis, sedimentation velocity measurement by ultracentrifuge and saturation transfer difference measurement (STD) by NMR on HPN-collagen in solution state. The circular dichroism and sedimentation velocity measurement showed the evidence for the molecular interaction between ATCL and HPN, while HPN did not induce any conformational change of ATCL. The STD-NMR study further confirmed this interaction and suggested that HPN interacted with ATCL through its aromatic part, not through its disaccharide moiety. These findings indicated that HPN is weakly bound to ATCL not causing structural modification of collagen. This interaction may contribute to the preservation of collagen by protecting from collagenase degradation. Copyright © 2016 The Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  8. Intervenção de base comunitária para a prevenção das DST/Aids na região amazônica, Brasil Community-based intervention to control STD/AIDS in the Amazon region, Brazil

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    Adele Schwartz Benzaken


    Full Text Available OBJETIVO: Descrever estudo de caso de intervenção de base comunitária, desenvolvido na perspectiva construcionista-emancipatória, para o controle das DST/Aids. MÉTODOS: Estudo descritivo desenvolvido no município de Manacapuru, Amazonas, de 1997-2004, sobre a utilização de procedimentos desenhados em colaboração com agentes governamentais, profissionais de saúde e comunidade. Foram levantados dados sobre a dinâmica da prostituição e a venda de preservativos na cidade, características comportamentais, avaliação do processo e da assistência às DST/Aids. Sincronicamente, estabeleceram-se ações de prevenção e assistência na rede pública de saúde às DST, centro de testagem, sistema de vigilância epidemiológica, e capacitação de trabalhadoras do sexo. RESULTADOS: Observou-se o fortalecimento das trabalhadoras do sexo como multiplicadoras e sua legitimação como cidadãs e agentes de saúde em projetos com travestis, homossexuais e escolares. Houve incremento da venda de preservativos na cidade, da utilização de preservativos entre trabalhadoras do sexo, redução das DST bacterianas e estabilização da ocorrência de infecção pelo HIV/Aids e sífilis congênita. A sustentabilidade do programa de intervenção estudado, organizado no âmbito do Sistema Único de Saude, foi estimulada pela pactuação política garantindo sede e orçamento regulamentado em lei municipal, e pelo debate permanente dos resultados do processo e programa. CONCLUSÕES: O estudo fortaleceu a noção de que o controle efetivo das DST/Aids depende de uma abordagem sinérgica que combine intervenções no plano individual (biológica-comportamental, sociocultural e programático.OBJECTIVE: To describe a case study of community-based intervention, developed in a constructionist-emancipatory framework to control STD/AIDS. METHODS: Descriptive study developed in the town of Manacapuru, in the state of Amazonas, from 1997 to 2004, focusing on

  9. Creatine CEST MRI for Differentiating Gliomas with Different Degrees of Aggressiveness. (United States)

    Cai, Kejia; Tain, Rong-Wen; Zhou, Xiaohong Joe; Damen, Frederick C; Scotti, Alessandro M; Hariharan, Hari; Poptani, Harish; Reddy, Ravinder


    Creatine (Cr) is a major metabolite in the bioenergetic system. Measurement of Cr using conventional MR spectroscopy (MRS) suffers from low spatial resolution and relatively long acquisition times. Creatine chemical exchange saturation transfer (CrCEST) magnetic resonance imaging (MRI) is an emerging molecular imaging method for tissue Cr measurements. Our previous study showed that the CrCEST contrast, obtained through multicomponent Z-spectral fitting, was lower in tumors compared to normal brain, which further reduced with tumor progression. The current study was aimed to investigate if CrCEST MRI can also be useful for differentiating gliomas with different degrees of aggressiveness. Intracranial 9L gliosarcoma and F98 glioma bearing rats with matched tumor size were scanned with a 9.4 T MRI scanner at two time points. CEST Z-spectra were collected using a customized sequence with a frequency-selective rectangular saturation pulse (B1 = 50 Hz, duration = 3 s) followed by a single-shot readout. Z spectral data were fitted pixel-wise with five Lorentzian functions, and maps of CrCEST peak amplitude, linewidth, and integral were produced. For comparison, single-voxel proton MR spectroscopy ((1)H-MRS) was performed to quantify and compare the total Cr concentration in the tumor. CrCEST contrasts decreased with tumor progression from weeks 3 to 4 in both 9L and F98 phenotypes. More importantly, F98 tumors had significantly lower CrCEST integral compared to 9L tumors. On the other hand, integrals of other Z-spectral components were unable to differentiate both tumor progression and phenotype with limited sample size. Given that F98 is a more aggressive tumor than 9L, this study suggests that CrCEST MRI may help differentiate gliomas with different aggressiveness.

  10. 7T Magnetization Transfer and Chemical Exchange Saturation Transfer MRI of Cortical Gray Matter: Can We Detect Neurochemical and Macromolecular Abnormalities? (United States)


    Gochberg DF, Hirtle JA, Gore JC , Smith SA. Quantitative magnetization transfer imaging of human brain at 7 T. NeuroImage 2013;64:640-649.3625658 11. Jones...tions (M0f and M0m), spin– lattice relaxation rates (R1f and R1m), and spin–spin relaxation rates (R2f and R2m) for each pool as well as an

  11. 7T Magnetization Transfer and Chemical Exchange Saturation Transfer MRI of Cortical Gray Matter: Can We Detect Neurochemical and Macromolecular Abnormalities (United States)


    optic nerve , but also have disseminated these methods to collaborators outside of Vanderbilt for application to patients with brain tumors (see...Characterization of the Optic Nerve in vivo using High-resolution APT-CEST), and 1 abstract presented at the annual VUIIS retreat (Conrad B, Dethrage LM...for the quantification of macromolecular and metabolic indices reflective of demyelination and neurotransmitter /protein accumulation. All quantitative

  12. Psychosocial and behavioral factors associated to STD/AIDS risk among health students Factores psicosociales y comportamentales asociados al riesgo de ETS/SIDA entre estudiantes del área de la salud Fatores psicossociais e comportamentais associados ao risco de DST/AIDS entre estudantes da área de saúde

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    Elma Mathias Dessunti


    Full Text Available This study aimed to identify and compare psychosocial and behavioral factors associated to STD/AIDS risk among students enrolled in the first and last years of the Nursing and Medical Undergraduate Programs at State University of Londrina. A convenience sample was selected from 263 enrolled students, and the 183 students who were sexually active (70.4% had their data assessed. The Aids Risk Reduction Model framework was used to design the questionnaire in which a 5% statistical significance level was considered. Some risk factors were identified such as the perception of invulnerability, multiple sexual partners, consumption of alcoholic beverages before intercourse, and the discontinuous use or no use of condom. The risk factors are common both to the freshman and senior students, with no significant differences related to the passage of time or to the students' higher educational level. Senior students tend to be monogamous which makes them feel safer and decrease the use of condom with their sexual partners.Este estudio tuvo como objetivo identificar y comparar los factores psico-sociales y comportamentales asociados al riesgo de ETS/sida entre estudiantes del primero y del último año de los cursos de Enfermería y Medicina de la Universidad Estatal de Londrina. Fue seleccionada una muestra por conveniencia, compuesta por 263 alumnos matriculados, de los cuales fueron analizadas las informaciones de 183 estudiantes sexualmente activos (70,4%. Para la elaboración del cuestionario, se utilizó la estructura del Modelo de Reducción de Riesgo de Sida, adoptándose el 5% como nivel significativo. Algunos factores de riesgo fueron identificados tales como, la percepción por la falta de vulnerabilidad, múltiples compañeros sexuales, el uso de bebidas alcohólicas antes de las relaciones sexuales y la falta de uso o uso descontinuado del preservativo. Se concluyó que, esos factores son comunes a los dos grupos, no generándose cambios

  13. Sexualidade e prevenção de DST/AIDS: representações sociais de homens rurais de um município da zona da mata pernambucana, Brasil Sexuality and STD/AIDS prevention: social representations by rural men in a county in the Zona da Mata region in Pernambuco, Brazil

    Directory of Open Access Journals (Sweden)

    Maria de Fátima Paz Alves


    Full Text Available Neste trabalho analisamos as concepções de homens rurais residentes na zona da mata pernambucana sobre suas práticas sexuais e a prevenção de DST/AIDS. Ele baseia-se numa metodologia de natureza qualitativa, tendo sido entrevistados 22 homens. Os resultados indicam que a primeira relação sexual destes apresenta um caráter de aprendizado, sendo marcada, por vezes, pela violência. Que eles fazem distinção entre mulheres "de casa e da rua", reconhecem o desejo feminino e valorizam a reciprocidade nas relações sexuais, diferenciando o sexo que se faz com distintas categorias de mulheres. Sete homens relatam experiências homoeróticas na adolescência, atribuídas à imaturidade, que não afetam a identidade heterossexual. O uso do preservativo, percebido negativamente, é inconstante e irregular, concorrendo com o conhecimento da parceira. As DSTs são pouco temidas ao passo que a AIDS é associada à morte, não vendo-se os entrevistados sob risco de contraí-la. Ambigüidades presentes no discurso, aliadas a uma atuação pouco eficaz dos serviços de saúde e campanhas de prevenção, evidenciam um elevado nível de exposição ao risco de contrair DST/AIDS por parte dos entrevistados e suas/seus parceiras/os.This study analyzes the concepts displayed by rural men in the Zona da Mata region in the State of Pernambuco, Brazil, concerning their sexual practices and STD/AIDS prevention. The study adopts a qualitative methodology, having interviewed 22 men According to the interviews, their first sexual intercourse is characterized as a learning experience and is sometimes marked by violence. They make a distinction between the "woman at home" and "street women"; they acknowledge women's sexual desire and value reciprocity in sexual relations, differentiating between the kinds of sex they have with different categories of women. Seven men report homoerotic experiences during adolescence, which they ascribe to immaturity, not affecting

  14. Does PCSI Make a Difference?

    Centers for Disease Control (CDC) Podcasts


    This podcast discusses the impact that PCSI makes by providing comprehensive, high-quality, evidence-based holistic care and prevention services to appropriate populations, whenever they interact with the health system, to achieve multiple related health goals.  Created: 12/7/2009 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP).   Date Released: 12/7/2009.

  15. Vivências de mulheres com diagnóstico de doença sexualmente transmissível - DST Experiencias de Mujeres con Diagnóstico de Enfermedad Sexualmente Transmisible - ETS Women's Experiences with Sexually Transmitted Disease Diagnosis - STD

    Directory of Open Access Journals (Sweden)

    Maria Alix Leite Araújo


    relaciones con la pareja sexual. El acto de aconsejar desempeña papel fundamental para la reducción de estrese. Los servicios de salud deben valorar los aspectos emocionales relacionados al diagnóstico de ETS, visando contribuir para el mejoramiento de la calidad de vida de las mujeres y en el abordaje de la pareja.The sexually transmissible diseases (STD constitutes problem of public health, because of the high prevalence. For the women, the control is a challenge, because of the social implications and mainly of gender. This objective of this study was to know as the women feel the diagnosis of a STD and the repercussions of the revelation of this diagnosis to the sexual partner. Exploratory-descriptive study developed in a unit of reference health for STD in Fortaleza Ceará (Brazil. The collection of the data was accomplished the months of February and March in 2006 and the analyzed in two categories: women's experiences with STD diagnosis and the repercussion of the revelation of the STD diagnosis to the sexual partner. It was verified that the occurrence of other STD results a negative impact for the woman in a social relationship with a sexual partner. A word of advice is a fundamental work to reduce the stress. The services of health should valorize the emotional aspects related of the diagnosis other STD, with the vision to contribute with the improvement of the quality of the woman life and approach with the partner.

  16. Intervenção comunitária e redução da vulnerabilidade de mulheres às DST/ Aids em São Paulo, SP Community based intervention and reduction of women's vulnerability to STD/AIDS in Brazil

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    Regina Figueiredo


    uma ação preventiva sustentada.OBJECTIVES: Despite the growing number of AIDS cases in women reported, community-based interventions, which are essential in this context, are scarce and rarely evaluated. The aim of this study was to carry out a community-based research intervention, to develop and evaluate a set of STD/ AIDS prevention actions targeting the vulnerability of low income women population. METHODS: The study was carried out in Monte Azul slum in the city of São Paulo, SP, Brazil, in the period 1998-1999. The following actions were put in place: training of health professionals from the local outpatient clinic, availability of prevention resources (male and female condoms, educational groups, educational materials and community radio programs. For evaluating intervention, data from four different research instruments were assessed: pre and post training testing of health professionals, monitoring of condom supply, direct observation of community activities, and record of health professionals and target population's voluntary statements during activities. RESULTS: It was observed an increase in demand for male condom and an interest in female condoms. There were relevant gender and age differences in adhering to proposed activities. Although there were good results regarding sensitization and training of health professionals, their involvement in prevention activities was limited. CONCLUSIONS: Strategies relating to codes, demands and specific interests of the local society, especially those related to gender roles, have successfully performed as preventive actions. Health professionals' overwork at the local outpatient clinic proved to be an important limitation for maintaining preventive actions.

  17. Different Venues, Different Markets, Different Experiences: Evidence ...

    African Journals Online (AJOL)

    The purpose of this research was to determine whether visitors who attend the same live music performance at four different destinations/locations vary and whether their needs were the same for a memorable visitor experience. Two-way frequency tables and Chi-square tests, as well as ANOVA and Tukey's multiple ...

  18. Microbial production of volatile sulphur compounds in the large intestine of pigs fed two different diets

    DEFF Research Database (Denmark)

    Poulsen, Henrik Vestergaard; Jensen, Bent Borg; Finster, Kai


    Aims: To investigate the production of volatile sulphur compounds (VSC) in segments of the large intestine of pigs and to assess the impact of diet on this production. Methods and Results: Pigs were fed two diets based on either wheat and barley (STD) or wheat and dried distillers grains...... increase along the large intestine, whereas no diet-related differences were observed. Conclusion: VSC net production varies widely throughout the large intestine of pigs and the microbial processes involved in this production can be affected by diet. Significance and Impact of the study: This first report...... on intestinal production of all VSC shows both spatial and dietary effects, which are relevant to both bowel disease- and odour mitigation research....

  19. A implantação do quesito cor/raça nos serviços de DST/Aids no Estado de São Paulo The implementation of the question regarding color/race in STD/AIDS services in the State of São Paulo

    Directory of Open Access Journals (Sweden)

    Márcia Regina Giovanetti


    Full Text Available INTRODUÇÃO: O artigo apresenta experiência de implantação e implementação do quesito cor/raça nos serviços de atendimento às DST/Aids no Estado de São Paulo (ESP, através de parceria firmada em 2004 entre a Divisão de Prevenção do Programa Estadual DST/Aids do ESP e o Centro de Estudos das Relações de Trabalho e Desigualdade (CEERT, visando executar um projeto serviços. Trinta e cinco serviços de atendimento às DST/Aids foram envolvidos no projeto e foram realizadas, de 2004 e 2006, sete oficinas de sensibilização e monitoramento do processo de implantação do quesito cor/raça, segundo metodologia de construção participativa e compartilhada do conhecimento, proposta pelo CEERT. Como resultado, verificou-se que o processo de discussão e de reflexão da temática étnico-racial torna a implantação do quesito cor/raça mais fácil. Os folhetos e cartazes propiciam o esclarecimento de profissionais e usuários, facilitando a implantação do quesito. Investir na capacitação dos profissionais da recepção dos usuários é importante para a implantação desse quesito nos serviços de saúde. CONCLUSÃO: A partir desta experiência o Grupo de Trabalho Etnias do Programa Estadual DST/Aids vem ampliando sua atuação. Em 2006, com a parceria das profissionais do Instituto AMA-Psique, iniciou-se o processo para 13 novos municípios, consolidando a implantação do quesito cor/raça no ESP. Esperamos que as informações produzidas possam sensibilizar as diversas esferas, para que sejam propostas e aprovadas políticas públicas que promovam a eqüidade racial na saúde e a qualidade de vida para população negra e indígena.This paper describes the experience to implement a systematic collection of these data on color/race in the STD/Aids care services in the State of São Paulo (SSP, through a partnership signed in 2004 between the Prevention Division of the STD/Aids State Program of the SSP and CEERT (initials in

  20. Different antisemitisms

    DEFF Research Database (Denmark)

    Dencik, Lasse; Marosi, Karl

    different from each other. Their findings indicate that each type is based on a particular underlying philosophy, is held by sociologically distinct groups of people, and is manifested in different ways. The report, entitled Different Antisemitisms: Perceptions and experiences of antisemitism among Jews...

  1. Marble bowing: comparative studies of three different public building facades (United States)

    Siegesmund, S.; Ruedrich, J.; Koch, A.


    The veneer cladding of the Oeconomicum (OEC, Göttingen), the State Theatre of Darmstadt (STD, Darmstadt) and of the State and University Library (SUB, Göttingen) is characterised by pronounced bowing after a short time of exposure. Direct comparison of bowing data related to measurements from 2000 to 2003 at the SUB clearly show that the amplitude in bowing had significantly increased. The bowing is different in intensity and orientation (concave, convex). The cladding material (Peccia marble, Rosa Estremoz marble and Carrara marble) are different in lattice preferred orientation, grain size distribution and grain interlocking. Depending on the bowing, panels may show cracks mostly initiated at the dowels. The percentage of visible cracks and breakouts increases with the amplitude of bowing except for the STD. Repetitive heating-cooling under dry conditions leads to considerable inelastic residual strain only after the first or second thermal cycle. The residual strain continuously increases again if water is present, whereby the moisture content after a thermal cycle has a certain impact on the decay rate. The water-enhanced thermal dilatation strongly correlates with the deterioration rate obtained from the laboratory bow test. Detailed petrophysical investigations provide evidence that with increasing bowing a decrease of mechanical properties (flexural strength or breaking load at dowel hole) occur. Marble degradation is also connected with the increase in porosity and a general shift of the maximum pore radii to larger pore sizes. On-site damage analyses were combined with laboratory tests of the bowing potential to constrain factors that may influence the risk failure. The experimental bowing data clearly demonstrate that after 40 heating cycles combined with the effect of moisture a certain impact on the decay rate is observed. In the case of demounted panels the bowing tests show that already strongly deformed panels from the building exhibit a lower

  2. Prevalência e fatores correlatos de infecção pelo hiv e sífilis em prostitutas atendidas em centro de referência DST/AIDS Prevalence and correlates of hiv infection and syphilis in prostitutes attending a STD/AIDS reference center

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    Isabel Cristina Pinheiro Pires


    Full Text Available Um estudo retrospectivo foi conduzido com análise dos prontuários médicos de prostitutas atendidas no Centro de Referência para DST/AIDS em Vitória (ES no período de janeiro de 1993 a dezembro de 1996. Durante este período, 180 mulheres receberam atendimento médico e psicológico nesta clínica. A média de idade foi de 25,9 anos (DP = 6,8. De um total de 180 mulheres, 140 concordaram em serem testadas para HIV, das quais 12 (8,6% apresentaram resultado positivo. De 157 mulheres que concordaram em serem testadas para sífilis, 13 (8,3% apresentaram o VDRL positivo. Quanto ao nível de educação, 6 mulheres (3,3% eram analfabetas, 114 (63,3% completaram o primeiro grau, 37 (20,6% estudaram até o segundo grau, 7 (3,9% estavam na universidade e 16 (8,9% não quiseram informar. Quanto ao estado civil, 141 (78,3% eram solteiras, 17 (9,4% casadas, 10 (5,5% divorciadas e 4 (2,2% viúvas. Quanto à freqüência do uso de condom, 56 (31,3% relataram que sempre usavam, 93 (52,0% às vezes e 30 (16,8% nunca usavam. Doenças sexualmente transmissíveis (DST prévias foram relatadas por 89 mulheres (49,4% e 46 (25,6% apresentavam alguma DST na ocasião da consulta. Nove mulheres (5,0% relataram uso de drogas injetáveis. Houve diferença estatisticamente significante entre o grupo com sorologia para HIV negativo e o positivo quando se comparou o uso de drogas injetáveis (p=0,031 e a infecção por sífilis (p=0,014. O presente estudo mostrou que as taxas de prevalência da infecção pelo HIV em trabalhadoras do sexo são mais altas que as encontradas na população em geral. Isto aponta para a necessidade de reforçar a assistência médica e campanhas educativas, especialmente direcionadas para esta população de mulheres, abordando a importância do uso regular do preservativo e dos riscos associados ao uso de drogas injetáveis.A retrospective study examining medical records of female prostitutes attending the STD/AIDS Reference Center in Vit

  3. Las relaciones coitales y la percepción de riesgo de adquirir ETS/SIDA en adultos jóvenes varones de Lima, Perú Sexual relations and the perception of risk of acquiring STD/AIDS among young adult men in Lima, Peru

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    Jesús L. Chirinos


    Full Text Available Para identificar la corresponsabilidad de los varones en el proceso de negociación de protección dual, según género en la primera y última relación sexual, y su percepción de riesgo de ETS/SIDA, se encuestó a 750 varones de 19-29 años en 2.250 viviendas de Lima Metropolitana, Perú, 2001, seleccionados aleatoriamente. La mayoría señaló principalmente el condón como una forma para evitar el embarazo (95%. La primera relación coital fue con la amiga, su pareja estable o una conocida. Casi la mitad de ellos hizo algo para cuidarse, principalmente usó condón para evitar un embarazo, pero su uso consistente y correcto son bajos. El 39,5% tuvo su última relación coital con su pareja estable con quien no vive, con amiga o "conocida", la esposa o conviviente. El diálogo sobre protegerse se incrementa entre la primera y la última relación coital. Su percepción del riesgo de adquirir ETS/SIDA es baja y se protegen sólo con parejas "desconocidas".The purpose of this study was to identify men's co-responsibility in the negotiation process of dual protection, according gender, in their first and most recent sexual relationships, and their perception of the risk of STD/AIDS. We surveyed 750 males from 19 to 29 years of age in 2,250 randomly selected households in metropolitan Lima, Peru. The majority mentioned condoms as a contraceptive technique (95%. Their first sexual relationships occurred with a female friend, with a stable partner, or with a known woman. Almost half used some type of protection, principally condoms in order to avoid pregnancy, but their consistent and correct use was low. For 39.5%, the most recent sexual relationship was with a stable partner, a female friend or "known" woman, a wife, or a female co-resident. Dialogue about protection increased between the first and the most recent sexual relationships. The perception of risk of acquiring STD/AIDS was low, and they tended to use protection only with an "unknown

  4. Electrical, Electronic, and Electromechanical (EEE) Parts Management and Control Requirements for Space Flight Hardware and Critical Ground Support Equipment...aka... The NASA EEE Parts Standard, NASA-STD 8739.10 (United States)

    Majewicz, Peter; Sampson, Michael


    Describes development and content of a new NASA Standard for Electrical Electronic and Electromechanical (EEE) parts. This Standard reflects current practices, instead of changing them. Most NASA Centers utilize local documents, but there is minimal consistency across the Agency. A gap analysis clearly shows the differences that exist among the different centers and with respect to the NASA Parts Policy. Once approved, the new standard can be referenced in contracts and agreements with organizations outside of NASA.

  5. Prevalence of Neisseria gonorrhoeae and Chlamydia trachomatis infection in men attending STD clinics in Brazil Prevalência de Neisseria gonorrhoeae e infecção pela Chlamydia trachomatis em homens atendidos em clínicas de DST no Brasil

    Directory of Open Access Journals (Sweden)

    Marcelo Joaquim Barbosa


    Full Text Available INTRODUCTION: The study aimed to assess the prevalence of Neisseria gonorrhoeae and Chlamydia trachomatis infections and identify demographic, behavioral and clinical factors correlated withsuch infections in men attending six sexually transmitted disease clinics in Brazil. METHODS: Multicentric, cross-sectional study performed among men attending STD clinics in Brazil. The study included STD clinics in six cities distributed throughout the five geographic regions of Brazil in 2005. Patients provided 20 ml of first catch urine for testing for NG and CT by DNA-PCR. RESULTS: A total of 767 (92.9% men were included in the study. The mean age was 26.5 (SD 8.3 years-old. Prevalence of Chlamydia infection was 13.1% (95%CI 10.7%-15.5% and gonorrhea was 18.4% (95%CI 15.7%-21.1%. Coinfection prevalence was 4.4% (95%CI 2.95%-5.85% in men who sought attendance in STI clinics. Factors identified as associated with C. trachomatis were younger age (15-24 [OR=1.4 (95%CI 1.01-1.91], present urethral discharge [OR=4.8 (95%CI 1.52-15.05], genital warts [OR=3.0 (95%CI 1.49-5.92] and previous history of urethral discharge [OR=2.4 (95%CI 1.11-5.18]. Variables associated with gonorrhea were younger age (15 to 24 [OR=1.5 (95%CI 1.09-2.05], presence of urethral discharge [OR=9.9 (95%CI 5.53-17.79], genital warts [OR=18.3 (95%CI 8.03-41.60] and ulcer present upon clinical examination [OR=4.9 (95%CI 1.06-22.73]. CONCLUSIONS: These findings have important implications for education and prevention actions directed toward men at risk of HIV/STD. A venue-based approach to offer routine screening for young men in STD clinics should be stimulated.INTRODUÇÃO: Nosso objetivo foi acessar a prevalência de Neisseria gonorrhoeae e Chlamydia trachomatis e identificar fatores demográficos, comportamentais e clínicos correlacionados a essas infecções em homens atendidos em clínicas de doenças sexualmente transmissíveis no Brasil. MÉTODOS: Estudo multicêntrico, transversal

  6. Textbook difference

    DEFF Research Database (Denmark)

    Bennike, Rune Bolding


    This article examines the transformation of the diverse imperial landscape of the Gorkha Kingdom into the more uniform and integrated space of the Nepali nation. It argues that nationalised schooling, as it was introduced under Panchayat rule (1960–90), was central to the production of national...... space. However, it also highlights how this schooling concomitantly extended a language of ‘anthropological’ and ‘ecological’ difference with which to organise and negotiate this space. Below the textbook surface of unity-in-diversity, remnants of imperial caste and racial hierarchies remained. And....... In conclusion, the article suggests how the languages of difference built up across Panchayat and present-day schooling continue to shape contemporary re-imaginings of national space, in the midst of political uncertainties....

  7. Lower Bound on Estimation Variance of the Ultrasonic Attenuation Coefficient Using the Spectral-Difference Reference-phantom Method. (United States)

    Samimi, Kayvan; Varghese, Tomy


    Ultrasonic attenuation is one of the primary parameters of interest in Quantitative Ultrasound (QUS). Non-invasive monitoring of tissue attenuation can provide valuable diagnostic and prognostic information to the physician. The Reference Phantom Method (RPM) was introduced as a way of mitigating some of the system-related effects and biases to facilitate clinical QUS applications. In this paper, under the assumption of diffuse scattering, a probabilistic model of the backscattered signal spectrum is used to derive a theoretical lower bound on the estimation variance of the attenuation coefficient using the Spectral-Difference RPM. The theoretical lower bound is compared to simulated and experimental attenuation estimation statistics in tissue-mimicking (TM) phantoms. Estimation standard deviation (STD) of the sample attenuation in a region of interest (ROI) of the TM phantom is measured for various combinations of processing parameters, including Radio-Frequency (RF) data block length (i.e., window length) from 3 to 17 mm, RF data block width from 10 to 100 A-lines, and number of RF data blocks per attenuation estimation ROI from 3 to 10. In addition to the Spectral-Difference RPM, local attenuation estimation for simulated and experimental data sets was also performed using a modified implementation of the Spectral Fit Method (SFM). Estimation statistics of the SFM are compared to theoretical variance predictions from the literature.(1) Measured STD curves are observed to lie above the theoretical lower bound curves, thus experimentally verifying the validity of the derived bounds. This theoretical framework benefits tissue characterization efforts by isolating processing parameter ranges that could provide required precision levels in estimation of the ultrasonic attenuation coefficient using Spectral Difference methods.

  8. Aging Differently

    DEFF Research Database (Denmark)

    Zajitschek, Felix; Jin, Tuo; Colchero, Fernando


    Diet effects on age-dependent mortality patterns are well documented in a large number of animal species, but studies that look at the effects of nutrient availability on late-life mortality plateaus are lacking. Here, we focus on the effect of dietary protein content (low, intermediate, and high...... based on Bayesian inference of age-specific mortality rates and found a deceleration of late-life mortality rates on all diets in males but only on the intermediate (standard) diet in females. The difference in mortality rate deceleration between males and females on extreme diets suggests...

  9. How Epigallocatechin-3-gallate and Tetracycline Interact with the Josephin Domain of Ataxin-3 and Alter Its Aggregation Mode. (United States)

    Bonanomi, Marcella; Visentin, Cristina; Natalello, Antonino; Spinelli, Michela; Vanoni, Marco; Airoldi, Cristina; Regonesi, Maria E; Tortora, Paolo


    Epigallocatechin-3-gallate (EGCG) and tetracycline are two known inhibitors of amyloid aggregation able to counteract the fibrillation of most of the proteins involved in neurodegenerative diseases. We have recently investigated their effect on ataxin-3 (AT3), the polyglutamine-containing protein responsible for spinocerebellar ataxia type 3. We previously showed that EGCG and tetracycline can contrast the aggregation process and toxicity of expanded AT3, although by different mechanisms. Here, we have performed further experiments by using the sole Josephin domain (JD) to further elucidate the mechanism of action of the two compounds. By protein solubility assays and FTIR spectroscopy we have first observed that EGCG and tetracycline affect the JD aggregation essentially in the same way displayed when acting on the full-length expanded AT3. Then, by saturation transfer difference (STD) NMR experiments, we have shown that EGCG binds both the monomeric and the oligomeric JD form, whereas tetracycline can only interact with the oligomeric one. Surface plasmon resonance (SPR) analysis has confirmed the capability of the sole EGCG to bind monomeric JD, although with a KD value suggestive for a non-specific interaction. Our investigations provide new details on the JD interaction with EGCG and tetracycline, which could explain the different mechanisms by which the two compounds reduce the toxicity of AT3. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Photoreactive "nanorulers" detect a novel conformation of full length HDAC3-SMRT complex in solution. (United States)

    Abdelkarim, Hazem; Brunsteiner, Michael; Neelarapu, Raghupathi; Bai, He; Madriaga, Antonett; van Breemen, Richard B; Blond, Sylvie Y; Gaponenko, Vadim; Petukhov, Pavel A


    Histone deacetylase 3 (HDAC3) is a promising epigenetic drug target for multiple therapeutic applications. Direct interaction between the Deacetylase Activating Domain of the silencing mediator for retinoid or thyroid-hormone receptors (SMRT-DAD) is required for activation of enzymatic activity of HDAC3. The structure of this complex and the nature of interactions with HDAC inhibitors in solution are unknown. Using novel photoreactive HDAC probes, "nanorulers", we determined the distance between the catalytic site of the full-length HDAC3 and SMRT-DAD in solution at physiologically relevant conditions and found it to be substantially different from that predicted by the X-ray model with a Δ379-428 aa truncated HDAC3. Further experiments indicated that in solution this distance might change in response to chemical stimuli, while the enzymatic activity remained unaffected. These observations were further validated by Saturation Transfer Difference (STD) NMR experiments. We propose that the observed changes in the distance are an important part of the histone code that remains to be explored. Mapping direct interactions and distances between macromolecules with such "nanorulers" as a function of cellular events facilitates better understanding of basic biology and ways for its manipulation in a cell- and tissue-specific manner.

  11. Photoreactive “Nanorulers” Detect a Novel Conformation of Full length HDAC3-SMRT Complex in Solution (United States)

    Abdelkarim, Hazem; Brunsteiner, Michael; Neelarapu, Raghupathi; Bai, He; Madriaga, Antonett; van Breemen, Richard B.; Blond, Sylvie Y.; Gaponenko, Vadim; Petukhov, Pavel A.


    Histone deacetylase 3 (HDAC3) is a promising epigenetic drug target for multiple therapeutic applications. Direct interaction between the Deacetylase Activating Domain of the silencing mediator for retinoid or thyroid hormone receptors (SMRT-DAD) is required for activation of enzymatic activity of HDAC3. The structure of this complex and the nature of interactions with HDAC inhibitors in solution are unknown. Using novel photoreactive HDAC probes – “nanorulers”, we determined the distance between the catalytic site of the full-length HDAC3 and SMRT-DAD in solution at physiologically relevant conditions and found it to be substantially different from that predicted by the X-ray model with a Δ379-428aa truncated HDAC3. Further experiments indicated that in solution this distance might change in response to chemical stimuli, while the enzymatic activity remained unaffected. These observations were further validated by Saturation Transfer Difference (STD) NMR experiments. We propose that the observed changes in the distance are an important part of the histone code that remains to be explored. Mapping direct interactions and distances between macromolecules with such “nanorulers” as a function of cellular events facilitates better understanding of basic biology and ways for its manipulation in cell and tissue specific manner. PMID:24010878

  12. Application of virus-like particles (VLP) to NMR characterization of viral membrane protein interactions

    Energy Technology Data Exchange (ETDEWEB)

    Antanasijevic, Aleksandar; Kingsley, Carolyn [University of Illinois at Chicago, Department of Biochemistry and Molecular Genetics (United States); Basu, Arnab; Bowlin, Terry L. [Microbiotix Inc. (United States); Rong, Lijun [University of Illinois at Chicago, Department of Microbiology and Immunology (United States); Caffrey, Michael, E-mail: [University of Illinois at Chicago, Department of Biochemistry and Molecular Genetics (United States)


    The membrane proteins of viruses play critical roles in the virus life cycle and are attractive targets for therapeutic intervention. Virus-like particles (VLP) present the possibility to study the biochemical and biophysical properties of viral membrane proteins in their native environment. Specifically, the VLP constructs contain the entire protein sequence and are comprised of native membrane components including lipids, cholesterol, carbohydrates and cellular proteins. In this study we prepare VLP containing full-length hemagglutinin (HA) or neuraminidase (NA) from influenza and characterize their interactions with small molecule inhibitors. Using HA-VLP, we first show that VLP samples prepared using the standard sucrose gradient purification scheme contain significant amounts of serum proteins, which exhibit high potential for non-specific interactions, thereby complicating NMR studies of ligand-target interactions. We then show that the serum contaminants may be largely removed with the addition of a gel filtration chromatography step. Next, using HA-VLP we demonstrate that WaterLOGSY NMR is significantly more sensitive than Saturation Transfer Difference (STD) NMR for the study of ligand interactions with membrane bound targets. In addition, we compare the ligand orientation to HA embedded in VLP with that of recombinant HA by STD NMR. In a subsequent step, using NA-VLP we characterize the kinetic and binding properties of substrate analogs and inhibitors of NA, including study of the H274Y-NA mutant, which leads to wide spread resistance to current influenza antivirals. In summary, our work suggests that VLP have high potential to become standard tools in biochemical and biophysical studies of viral membrane proteins, particularly when VLP are highly purified and combined with control VLP containing native membrane proteins.

  13. Fiber Optics Applications for MIL-STD-1760. (United States)



  14. STD care in the South African private health sector | Schneider ...

    African Journals Online (AJOL)

    Objectives. To establish the accessibility and quality of sexually transmitted disease (SID) care provided by private general practitioners (GPs) and workplace health services in South Africa. Design. Structured telephone interviews were conducted with a random national sample of 120 GPs and 244 occupational health ...

  15. Psychosocial and Behavioural Factors Associated with STD/AIDS ...

    African Journals Online (AJOL)

    Aim: The study aimed to identify psychosocial and behavioural factors associated with Sexually transmitted infection (STI) including the Human immune deficiency Virus infection (HIV) risk among dental students in the clinical years of the Faculty of Dental Sciences at the College of Medicine, University of Lagos, Lagos ...

  16. Socio-economic aspects of extended STD screening in pregnancy

    NARCIS (Netherlands)

    Postma, Maarten; Jager, Johannes C; de Jong-van den Berg, L T


    Screening for sexually transmitted diseases (STDs) in early pregnancy is included in routine antenatal care for several infectious agents in many western European countries. Pharmaco-economics of these interventions have been evaluated. Currently, reconsideration of anternatal screening is ongoing,

  17. The Manicaland HIV/STD Prevention Project: Studies on HIV ...

    African Journals Online (AJOL)

    ... challenges faced in the search for effective measures to control the HIV epidemic. We also emphasise the need to identify and develop HIV control strategies that reflect spatial and temporal variations in the local socio-economic and epidemiological context. The Zimbabwe Science News Volume 35 (1+ 2) 2001, pp. 27-42 ...

  18. Role of STD Detection and Treatment in HIV Prevention (United States)

    ... Infection STDs Home Page Bacterial Vaginosis (BV) Chlamydia Gonorrhea Genital Herpes Hepatitis HIV/AIDS & STDs Human Papillomavirus ( ... In the United States, people who get syphilis, gonorrhea, and herpes often also have HIV, or are ...

  19. Sexual Risk Behavior: HIV, STD, & Teen Pregnancy Prevention (United States)

    ... Innovative Programs Additional Evaluation Resources Health & Academics Anti-Bullying Policies and Enumeration: An Infobrief for Local Education ... OIG 1600 Clifton Road Atlanta , GA 30329-4027 USA 800-CDC-INFO (800-232-4636) , TTY: 888- ...

  20. Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism. (United States)

    Jaudzems, Kristaps; Kuka, Janis; Gutsaits, Aleksandrs; Zinovjevs, Kirils; Kalvinsh, Ivars; Liepinsh, Edgars; Liepinsh, Edvards; Dambrova, Maija


    Carnitine acetyltransferase (CrAT; EC catalyzes the reversible transfer of acetyl groups between acetyl-coenzyme A (acetyl-CoA) and L-carnitine; it also regulates the cellular pool of CoA and the availability of activated acetyl groups. In this study, biochemical measurements, saturation transfer difference (STD) nuclear magnetic resonance (NMR) spectroscopy, and molecular docking were applied to give insights into the CrAT binding of a synthetic inhibitor, the cardioprotective drug mildronate (3-(2,2,2-trimethylhydrazinium)-propionate). The obtained results show that mildronate inhibits CrAT in a competitive manner through binding to the carnitine binding site, not the acetyl-CoA binding site. The bound conformation of mildronate closely resembles that of carnitine except for the orientation of the trimethylammonium group, which in the mildronate molecule is exposed to the solvent. The dissociation constant of the mildronate CrAT complex is approximately 0.1 mM, and the K(i) is 1.6 mM. The results suggest that the cardioprotective effect of mildronate might be partially mediated by CrAT inhibition and concomitant regulation of cellular energy metabolism pathways.

  1. Argumentos em torno da possibilidade de infecção por DST e Aids entre mulheres que se autodefinem como lésbicas Arguments on the possibility of STD infection and Aids among women that define themselves as lesbians

    Directory of Open Access Journals (Sweden)

    G. Almeida


    Full Text Available A produção acadêmica motivada pela epidemia de HIV e Aids impulsionou as pesquisas relativas à sexualidade, configurando novos campos de investigação, em especial sobre os "gays". No entanto, não é significativa no Brasil a produção acadêmica que aborde a vulnerabilidade às DSTs a partir da identidade "lésbica". A saúde sexual das mulheres presumidamente heterossexuais tendeu a permanecer subsumida à exclusiva preocupação com a reprodução ao longo da trajetória das políticas de atenção à saúde das mulheres, mesmo frente à Aids. De forma ainda mais acentuada que a sexualidade feminina heterossexual, a homossexualidade feminina tendeu à invisibilidade na sociedade brasileira e frente ao discurso médico-ginecológico. O advento da epidemia contribuiu para a manutenção desta invisibilidade, por força da crença de que o "corpo lésbico" seria o único corpo infenso à infecção pela via sexual. A hipótese que norteou o presente trabalho está calcada na ideia de que a vulnerabilidade das lésbicas é o "passaporte" para a afirmação/inclusão de um dado marco identitário na agenda de políticas públicas.The academic production motivated by HIV and Aids epidemic has impelled research works related to the sexuality, configurating new investigation fields, mainly about gays. However, in Brazil, the academic production which addresses to the STD vulnerability, taking the lesbian identity into account, is not significant. The sexual health of women, expected to be heterosexual, was connected to the unique preoccupation about reproduction along the course of policies in terms of the attention to women's health, even facing Aids. Increasingly, considering the heterosexual female sexuality, female homosexuality has tended, in the Brazilian society, to become invisible in the medical / gynecologic speech. The epidemic contributed to this continuing invisibility, due to strong beliefs in which the "lesbian body" would be

  2. Avaliação da implantação de atividades de prevenção das DST/AIDS na atenção básica: um estudo de caso na Região Metropolitana de São Paulo, Brasil Evaluating the implementation of STD/AIDS prevention activities in primary health care facilities: a case study in Greater Metropolitan São Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Dulce Aurélia de Souza Ferraz


    Full Text Available Desde os anos 1990, a incorporação da prevenção das DST/AIDS na atenção básica é internacionalmente recomendada. No Brasil, investimentos para essa incorporação vêm sendo feitos pelo Ministério da Saúde. Esta pesquisa realiza uma avaliação da implantação dessas atividades, mediante estudo de caso em profundidade, realizado numa unidade de saúde da família da Região Metropolitana de São Paulo. Analisam-se o conjunto das atividades da unidade e aquelas específicas de prevenção das DST/AIDS, por meio de observações diretas e entrevistas semi-estruturadas com profissionais do serviço. Verifica-se que o perfil tecnológico da unidade se assemelha ao dos tradicionais serviços da atenção básica brasileiros, apresentando limitado potencial de concretização do princípio da integralidade. Incorporam-se atividades de prevenção das DST/ AIDS, porém esvaziadas de importantes sentidos tecnológicos, como o diálogo e a atenção à singularidade dos usuários. Esta e outras características revelam um tensionamento entre as propostas tecnológicas do programa e o perfil tecnológico atual da atenção básica. Entretanto, a explicitação desse tensionamento pode favorecer a reflexão sobre novos valores no cotidiano da atenção básica, potencializando a concretização de arranjos tecnológicos mais integrais.Since the 1990s, international guidelines have recommended the incorporation of STD/AIDS prevention in primary care. In Brazil, the Ministry of Health has made investments to include such preventive activities. This in-depth case study is an evaluation of the implementation of these activities in a family health unit in Greater Metropolitan São Paulo. The study analyzed the unit's activities as a whole and the specific STD/ AIDS prevention activities by means of direct observations and semi-structured interviews with the unit's professional health staff. The unit's technological characteristics were similar to

  3. Ele não quer com camisinha e eu quero me prevenir: exposição de adolescentes do sexo feminino às DST/aids no semi-árido nordestino He does not want it with condom and I want to protect myself: exposure of female adolescents to STD/AIDS in the semi-arid region of the Brazilian northeast

    Directory of Open Access Journals (Sweden)

    Juliana Sampaio


    Full Text Available A propagação da aids tem sofrido mudanças em seu perfil, e o aumento de casos em mulheres tem sido cada vez mais frequente, contribuindo de modo decisivo para o fenômeno chamado feminização da aids. Levando em consideração essa realidade, este trabalho tem por objetivo analisar a exposição de adolescentes às DST/aids no semiárido nordestino. A metodologia de trabalho utilizada foi baseada na abordagem qualitativa em saúde, utilizando como modelo teórico-metodológico as Práticas Discursivas e Produção de Sentido (Spink, 2004; Spink e Medrado, 1999. Ao todo três estratégias metodológicas foram utilizadas para a coleta de dados: 1024 horas de observação participante, 72 entrevistas semiestruturadas e 36 grupos focais, englobando dois grupos de atores: 72 profissionais de 8 equipes de saúde e 360 adolescentes, de ambos os sexos. A partir da análise dos resultados, constatou-se que a realidade nordestina é permeada por características que tornam a mulher vulnerável às DST/aids, tais como: a a baixa escolaridade; b as relações desiguais de gênero; c a ausência de uma política de prevenção direcionada ao público adolescente; d a inexistência de vínculo entre profissionais da saúde e população; e e a frequente compreensão dos serviços de saúde como espaço exclusivamente da mulher. Diante desse contexto, aponta-se a necessidade da efetivação de políticas de atenção à saúde integral de adolescentes, que trabalhem os direitos sexuais e reprodutivos na perspectiva de gênero, para a efetiva prevenção das DST/aids, exercendo impacto direto na promoção da qualidade de suas vidas.The dissemination of AIDS has suffered changes in its profile and the increase in cases among women has been more and more frequent, contributing decisively to the phenomenon called the feminization of AIDS. Taking this fact into account, the objective of this work is to examine the exposure of adolescents to STD / AIDS in the

  4. Analyzing the impact of ambient temperature indicators on transformer life in different regions of Chinese mainland. (United States)

    Bai, Cui-fen; Gao, Wen-Sheng; Liu, Tong


    Regression analysis is applied to quantitatively analyze the impact of different ambient temperature characteristics on the transformer life at different locations of Chinese mainland. 200 typical locations in Chinese mainland are selected for the study. They are specially divided into six regions so that the subsequent analysis can be done in a regional context. For each region, the local historical ambient temperature and load data are provided as inputs variables of the life consumption model in IEEE Std. C57.91-1995 to estimate the transformer life at every location. Five ambient temperature indicators related to the transformer life are involved into the partial least squares regression to describe their impact on the transformer life. According to a contribution measurement criterion of partial least squares regression, three indicators are conclusively found to be the most important factors influencing the transformer life, and an explicit expression is provided to describe the relationship between the indicators and the transformer life for every region. The analysis result is applicable to the area where the temperature characteristics are similar to Chinese mainland, and the expressions obtained can be applied to the other locations that are not included in this paper if these three indicators are known.

  5. Analyzing the Impact of Ambient Temperature Indicators on Transformer Life in Different Regions of Chinese Mainland

    Directory of Open Access Journals (Sweden)

    Cui-fen Bai


    Full Text Available Regression analysis is applied to quantitatively analyze the impact of different ambient temperature characteristics on the transformer life at different locations of Chinese mainland. 200 typical locations in Chinese mainland are selected for the study. They are specially divided into six regions so that the subsequent analysis can be done in a regional context. For each region, the local historical ambient temperature and load data are provided as inputs variables of the life consumption model in IEEE Std. C57.91-1995 to estimate the transformer life at every location. Five ambient temperature indicators related to the transformer life are involved into the partial least squares regression to describe their impact on the transformer life. According to a contribution measurement criterion of partial least squares regression, three indicators are conclusively found to be the most important factors influencing the transformer life, and an explicit expression is provided to describe the relationship between the indicators and the transformer life for every region. The analysis result is applicable to the area where the temperature characteristics are similar to Chinese mainland, and the expressions obtained can be applied to the other locations that are not included in this paper if these three indicators are known.

  6. Sexualidade do idoso: comportamento para a prevenção de DST/AIDS Sexualidad de los ancianos: comportamiento para la prevención de ETS/SIDA Sexuality of the elderly: behavior for the prevention of STD/AIDS

    Directory of Open Access Journals (Sweden)

    Mariana Fonseca Laroque


    prevention of STD/AIDS. It is a qualitative, exploratory and descriptive study using a semi-structured questionnaire with open questions. The study subjects were six seniors who participated in a group in a Basic Health Unit. The results showed that older people have information about STDs, but it also evidences a poor observance of condom use. We conclude from this study that the aging process requires awareness of health professionals that the elderly are sexually active and therefore exposed to STDs, and that the issue of condom use should be a natural matter during consultations, group meetings and events that reach this population.

  7. Comunicação educativa do enfermeiro na promoção da saúde sexual do escolar Comunicación educativa del enfermero en la promoción de la salud sexual para escolares: ETS-SIDA Educative communication between nurses and students about STD/AIDS

    Directory of Open Access Journals (Sweden)

    Maria Alice F. Colli Oliveira


    trabajar conocimientos actualizados y habilidades direccionadas a la "no discriminación"de la sociedad y a la solidariedad, en razón de la existencia inminente del enfermo/enfermedad en la sociedad. Conciben el SIDA como enfermedad de sexual prevenible, sin embargo revelan desinformación en otros aspectos básicos, justificandose la necesidad de acciones educativas. Por lo tanto, sugerimos que los enfermeros trabajen efectivamente esta cuestión.As school has been a crucial space for the development of knowledge and abilities in order to assure changes of behavior and considering the lack of reports about sexuality and STD/AIDS to the students, the present study aims to search scholars from three classes of high school, from a town surrounding the city of Ribeirão Preto - São Paulo. Authors identified students' problems by carrying out and assessing joint educative actions on the problems that have been found. Results have showed that these students relate AIDS to fatality and temerity and perhaps they are influenced by the message issued at the first decade of the history of this disearse while now, the tendency is to work with up to date knowledge and abilities. They form an opinion about AIDS as a sex and preventible disease. A it however, authors detected misinformation in another basic aspects. Therefore, we suggest nurses to work hard with this question.

  8. Different Placebos, Different Mechanisms, Different Outcomes: Lessons for Clinical Trials.

    Directory of Open Access Journals (Sweden)

    Fabrizio Benedetti

    Full Text Available Clinical trials use placebos with the assumption that they are inert, thus all placebos are considered to be equal. Here we show that this assumption is wrong and that different placebo procedures are associated to different therapeutic rituals which, in turn, trigger different mechanisms and produce different therapeutic outcomes. We studied high altitude, or hypobaric hypoxia, headache, in which two different placebos were administered. The first was placebo oxygen inhaled through a mask, whereas the second was placebo aspirin swallowed with a pill. Both placebos were given after a conditioning procedure, whereby either real oxygen or real aspirin was administered for three consecutive sessions to reduce headache pain. We found that after real oxygen conditioning, placebo oxygen induced pain relief along with a reduction in ventilation, blood alkalosis and salivary prostaglandin (PGE2, yet without any increase in blood oxygen saturation (SO2. By contrast, after real aspirin conditioning, placebo aspirin induced pain relief through the inhibition of all the products of cyclooxygenase, that is, PGD2, PGE2, PGF2, PGI2, thromboxane (TXA2, without affecting ventilation and blood alkalosis. Therefore, two different placebos, associated to two different therapeutic rituals, used two different pathways to reduce headache pain. The analgesic effect following placebo oxygen was superior to placebo aspirin. These findings show that different placebos may use different mechanisms to reduce high altitude headache, depending on the therapeutic ritual and the route of administration. In clinical trials, placebos and outcome measures should be selected very carefully in order not to incur in wrong interpretations.

  9. Soil Organic Carbon Storage in Five Different Arctic Permafrost Environments (United States)

    Fuchs, M.; Grosse, G.; Jones, B. M.; Maximov, G.; Strauss, J.


    Arctic river deltas and ice-rich permafrost regions are highly dynamic environments which will be strongly affected by future climate change. Rapid thaw of permafrost (thermokarst and thermo-erosion) may cause significant mobilization of organic carbon, which is assumed to be stored in large amounts in Arctic river deltas and ice-rich permafrost. This study presents and compares new data on organic carbon storage in thermokarst landforms and Arctic river delta deposits for the first two meters of soils for five different study areas in Alaska and Siberia. The sites include the Ikpikpuk river delta (North Alaska), Fish Creek river delta (North Alaska), Teshekpuk Lake Special Area (North Alaska), Sobo-Sise Island (Lena river delta, Northeast Siberia), and Bykovsky Peninsula (Northeast Siberia). Samples were taken with a SIPRE auger along transects covering the main geomorphological landscape units in the study regions. Our results show a high variability in soil organic carbon storage among the different study sites. The studied profiles in the Teshekpuk Lake Special Area - dominated by drained thermokarst lake basins - contained significantly more carbon than the other areas. The Teshekpuk Lake Special Area contains 44 ± 9 kg C m-2 (0-100 cm, mean value of profiles ± Std dev) compared to 20 ± 7 kg C m-2 kg for Sobo-Sise Island - a Yedoma dominated island intersected by thaw lake basins and 24 ± 6 kg C m-2 for the deltaic dominated areas (Fish Creek and Ikpikpuk). However, especially for the Ikpikpuk river delta, a significant amount of carbon (25 ± 9 kg C m-2) is stored in the second meter of soil (100-200cm). This study shows the importance of including deltaic and thermokarst-affected landscapes as considerable carbon pools, but indicates that these areas are heterogeneous in terms of organic carbon storage and cannot be generalized. As a next step, the site-level carbon stocks will be upscaled to the landscape level using remote sensing-based land cover

  10. DST no âmbito da relação estável: análise cultural com base na perspectiva da mulher EST en el ámbito de la relación estable: análisis cultural con base en la perspectiva de la mujer STD in scope of long-term relationships: cultural analysis based on women's perspective

    Directory of Open Access Journals (Sweden)

    Leilane Barbosa de Sousa


    Full Text Available O trabalho teve como objetivo analisar as significações da contaminação por DST para a mulher em união estável. Trata-se de uma pesquisa etnográfica, baseada na Teoria do Cuidado Cultural. Desenvolveu-se o estudo no Centro de Desenvolvimento Familiar (CEDEFAM e no contexto familiar de sete mulheres, durante nove meses. Os resultados mostraram que o diagnóstico de DST influencia o comportamento sexual das mulheres. Em face disso, todavia, verificou-se que os homens parecem se comportar como coadjuvantes no processo e ainda consideram o problema como inerente apenas à parte feminina. Conclui-se que é imprescindível a abordagem da cultura nas ações de Educação em Saúde para a promoção da saúde sexual e reprodutiva do casal.El estudio tuvo la intención de analizar las significaciones de contaminación por EST para la mujer en unión estable. Se trata de una pesquisa etnográfica, basada en la Teoría Cultural. El estudio ocurrió en el Centro de Desarrollo Familiar (CEDEFAM y en el contexto familiar de siete mujeres durante nueve meses. Los resultados mostraran que el diagnóstico de EST influencia el comportamiento sexual de las mujeres. Todavía, se verificó que los hombres parecen se comportar como coadyuvantes en el proceso y aun consideran el problema como inherente solamente a la parte femenina. Se concluye que es imprescindible el abordaje de la cultura en las acciones de Educación en Salud para la promoción de la salud sexual y procreadora de la pareja. Se puede creer que, basados en estrategias de Educación en Salud culturalmente encaminadas, podrán ser alcanzados resultados de impacto positivo en la asimilación del riesgo y rotura de la cadena de transmisión de ESTs.This study aimed to analyze the meaning of STD contamination for the women with stable union. The present study is an ethnographical research, based on Theory of Cultural Care. The study was developed in the Center of Family Development (CEDEFAM and

  11. Physical violence against patients with mental disorders in Brazil: sex differences in a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Helian Nunes de Oliveira


    Full Text Available OBJECTIVES: Patients with mental illness are more exposed to violence than the general population. This study assessed factors associated with lifetime physical violence against these patients stratified by sex in Brazil. METHODS: This is a National cross-sectional multicenter study with a representative sample of 2,475 patients randomly selected from 26 public mental health services. Logistic regression was used to evaluate factors associated with physical violence and crude (OR and adjusted odds ratios (aOR with 95% confidence interval were estimated. Statistical level considered was 0.05. RESULTS: The prevalence of lifetime physical violence against mental patients was similar for women (57.6% and men (57.8%. Physical violence against women was independently associated with: previous psychiatric hospitalizations (aOR = 2.09, lifetime STD (aOR = 1.75, lifetime alcohol consumption (aOR = 1.59, age of sexual debut (< 16 y.o. (aOR = 1.40, lifetime sex under alcohol/drugs use (aOR = 2.08, having received/offered money for sex (aOR = 1.73 and lifetime incarceration (aOR = 1.69. Among men, associated factors were: age (18-40 y.o. (aOR = 1.90, history of homelessness (aOR = 1.71, previous psychiatric hospitalization (aOR = 1.39, lifetime STD (aOR = 1.52, lifetime alcohol consumption (aOR = 1.41, lifetime use of marijuana or cocaine (aOR = 1.54, having received/offered money for sex (aOR = 1.47, lifetime history of incarceration (aOR = 2.07. DISCUSSION: The prevalence of physical violence in this population was high for both sexes. Although there were similar factors independently associated with physical violence among men and women, there are important differences, such as age of sexual debut and lifetime sex under alcohol/drugs use for women, but not for men, while younger age, history of homelessness, and lifetime use of marijuana or cocaine were associated factors for men only. Screening for history of violence upon admission and early

  12. Two different hematocrit detection methods: Different methods, different results?

    Directory of Open Access Journals (Sweden)

    Schuepbach Reto A


    Full Text Available Abstract Background Less is known about the influence of hematocrit detection methodology on transfusion triggers. Therefore, the aim of the present study was to compare two different hematocrit-assessing methods. In a total of 50 critically ill patients hematocrit was analyzed using (1 blood gas analyzer (ABLflex 800 and (2 the central laboratory method (ADVIA® 2120 and compared. Findings Bland-Altman analysis for repeated measurements showed a good correlation with a bias of +1.39% and 2 SD of ± 3.12%. The 24%-hematocrit-group showed a correlation of r2 = 0.87. With a kappa of 0.56, 22.7% of the cases would have been transfused differently. In the-28%-hematocrit group with a similar correlation (r2 = 0.8 and a kappa of 0.58, 21% of the cases would have been transfused differently. Conclusions Despite a good agreement between the two methods used to determine hematocrit in clinical routine, the calculated difference of 1.4% might substantially influence transfusion triggers depending on the employed method.

  13. Strategies for Coping with Sexually Transmitted Diseases by Adolescent Females. (United States)

    Rosenthal, Susan L.; And Others


    Assessed adolescent females' perceptions of control over acquisition of a sexually transmitted disease (STD) and its emotional impact. No differences were found in coping strategies by age group or STD history. Subjects used numerous coping strategies--those viewing the future acquisition of a STD more negatively used more strategies. (RJM)

  14. Same same but different

    DEFF Research Database (Denmark)

    Brem, Alexander; Sproedt, Henrik


    Most academics and practitioner agree that design and business are interdependent and complementing. But in its application, differences appear. Hence, this article describes the frictions between design and business philosophy in practice by describing and discussing different approaches...

  15. Are different rhythms good for different functions?

    Directory of Open Access Journals (Sweden)

    Nancy Kopell


    Full Text Available This essay discusses the relationship between the physiology of rhythmsand potential functional roles. We focus on how the biophysics underlyingdifferent rhythms can give rise to different abilities of a network toform and manipulate cell assemblies. We also discuss how changes in themodulatory setting of the rhythms can change the flow of informationthrough cortical circuits, again tying physiology to computation. Wesuggest that diverse rhythms, or variations of a rhythm, can supportdifferent components of a cognitive act, with multiple rhythms potentiallyplaying multiple roles.

  16. A World of Difference. (United States)

    Lodish, Richard


    We all come to the human family--and our schools--with different kinds of intellectual baggage and different kinds of lingo to describe it. "Underprivileged" to one becomes "over-exploited" to another; the same goes for "multiculturalism" versus "ethnocentrism." We all must learn to share perceptions honestly and respect these differences. (MLH)

  17. An investigation into the effects of different existing states of aluminum isopropoxide on copper-based catalysts for direct synthesis of dimethyl ether from syngas (United States)

    Sun, Kai; Wang, Peng; Bian, Zhongkai; Huang, Wei


    Aluminum isopropoxide (AIP) is a vital raw material to produce high surface area alumina catalyst, which is used for catalytic applications, such as hydrocracking, Fischer-Tropsch and STD (syngas to dimethyl ether) reactions. However, the different existing states have an effect on hydrolysis and condensation in the process of precursor preparation. The Cu/Zn/Al slurry catalysts were prepared by aluminum isopropoxide, which were liquid state, crystalline state and solid state, utilizing a complete liquid phase preparation technology. In the dimethyl ether (DME) synthesis reaction, the aluminum resource of crystalline state was prepared for slurry catalyst, which presented high CO conversion and DME selectivity of 54.32% and 69.74%, respectively. Characterization results indicated that different forms of AIP have the variant coordination numbers of Al-O and polymerization degrees, and the catalyst prepared by crystalline state consists amount of tetra-coordinated Al and few hexa-coordinated Al, which can exert different hydrolysis and condensation process compared with other aluminum sources, and finally it contributes to the strong interaction between active site copper species and Zn/Al species, confirming more Cu+ is responsible for the synthesis of DME in the slurry reactor.

  18. Different drinking motives, different adverse consequences?

    DEFF Research Database (Denmark)

    Wicki, Matthias; Kuntsche, Emmanuel; Eichenberger, Yvonne


    , differences across countries were tested in a multigroup analysis. RESULTS: The indirect effect (via alcohol use) was greater for injuries and academic problems than for more general outcomes such as life dissatisfaction and negative body image. For social, enhancement and coping motives, we found positive...... indirect effects (via alcohol use) on injuries and academic problems; the association was negative for conformity motives. The direct effect, that is, the effect above and beyond alcohol use, indicated more negative consequences among those who tended to drink more frequently for coping motives. More......INTRODUCTION AND AIM: This study, which builds on previous research demonstrating that drinking motives are associated with adverse consequences, investigates the associations between drinking motives and non-alcohol-attributed adverse consequences and disentangles alcohol-related and direct...

  19. Acculturation through sport: Different contexts different meanings

    DEFF Research Database (Denmark)

    Elbe, Anne-Marie; Hatzigeorgiadis, Antonis; Morela, Eleftheria


    Research on the role of sport as a social integrative agent for migrants has provided equivocal results. The purpose of this study was to investigate the relation between ethnic–cultural identity and sport environmental factors. Young migrant male athletes from two different societal and sport...... contexts were studied: migrants from Eastern European countries living in Greece (n = 60) and from Latin America living in Spain (n = 60). Participants completed measures of ethnic and cultural identity, task-oriented motivational climate, and autonomysupportive coaching behaviour. Analysis of variance...... revealed that Eastern European inhabitants of Greece scored higher on fringe and assimilation, and lower on lack of interaction compared to Latin American inhabitants of Spain. In addition, for the former group, a mastery motivational climate and autonomy-supportive coaching predicted an integrative...

  20. The alphaGal epitope of the histo-blood group antigen family is a ligand for bovine norovirus Newbury2 expected to prevent cross-species transmission.

    Directory of Open Access Journals (Sweden)

    Maha Zakhour


    Full Text Available Among Caliciviridae, the norovirus genus encompasses enteric viruses that infect humans as well as several animal species, causing gastroenteritis. Porcine strains are classified together with human strains within genogroup II, whilst bovine norovirus strains represent genogroup III. Various GI and GII human strains bind to carbohydrates of the histo-blood group family which may be shared among mammalian species. Genetic relatedness of human and animal strains as well as the presence of potentially shared ligands raises the possibility of norovirus cross-species transmission. In the present study, we identified a carbohydrate ligand for the prototype bovine norovirus strain Bo/Newbury2/76/UK (NB2. Attachment of virus-like particles (VLPs of the NB2 strain to bovine gut tissue sections showed a complete match with the staining by reagents recognizing the Galalpha1,3 motif. Alpha-galactosidase treatment confirmed involvement of a terminal alpha-linked galactose. Specific binding of VLPs to the alphaGal epitope (Galalpha3Galbeta4GlcNAcbeta-R was observed. The binding of Galalpha3GalalphaOMe to rNB2 VLPs was characterized at atomic resolution employing saturation transfer difference (STD NMR experiments. Transfection of human cells with an alpha1,3galactosyltransferase cDNA allowed binding of NB2 VLPs, whilst inversely, attachment to porcine vascular endothelial cells was lost when the cells originated from an alpha1,3galactosyltransferase KO animal. The alphaGal epitope is expressed in all mammalian species with the exception of the Hominidaea family due to the inactivation of the alpha1,3galactosyltransferase gene (GGTA1. Accordingly, the NB2 carbohydrate ligand is absent from human tissues. Although expressed on porcine vascular endothelial cells, we observed that unlike in cows, it is not present on gut epithelial cells, suggesting that neither man nor pig could be infected by the NB2 bovine strain.

  1. Small-molecule inhibition of the uPAR·uPA interaction: synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis. (United States)

    Mani, Timmy; Wang, Fang; Knabe, William Eric; Sinn, Anthony L; Khanna, May; Jo, Inha; Sandusky, George E; Sledge, George W; Jones, David R; Khanna, Rajesh; Pollok, Karen E; Meroueh, Samy O


    The uPAR·uPA protein-protein interaction (PPI) is involved in signaling and proteolytic events that promote tumor invasion and metastasis. A previous study had identified 4 (IPR-803) from computational screening of a commercial chemical library and shown that the compound inhibited uPAR·uPA PPI in competition biochemical assays and invasion cellular studies. Here, we synthesize 4 to evaluate in vivo pharmacokinetic (PK) and efficacy studies in a murine breast cancer metastasis model. First, we show, using fluorescence polarization and saturation transfer difference (STD) NMR, that 4 binds directly to uPAR with sub-micromolar affinity of 0.2 μM. We show that 4 blocks invasion of breast MDA-MB-231, and inhibits matrix metalloproteinase (MMP) breakdown of the extracellular matrix (ECM). Derivatives of 4 also inhibited MMP activity and blocked invasion in a concentration-dependent manner. Compound 4 also impaired MDA-MB-231 cell adhesion and migration. Extensive in vivo PK studies in NOD-SCID mice revealed a half-life of nearly 5h and peak concentration of 5 μM. Similar levels of the inhibitor were detected in tumor tissue up to 10h. Female NSG mice inoculated with highly malignant TMD-MDA-MB-231 in their mammary fat pads showed that 4 impaired metastasis to the lungs with only four of the treated mice showing severe or marked metastasis compared to ten for the untreated mice. Compound 4 is a promising template for the development of compounds with enhanced PK parameters and greater efficacy. Copyright © 2013 Elsevier Ltd. All rights reserved.

  2. Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin. (United States)

    Sivertsen, Annfrid; Isaksson, Johan; Leiros, Hanna-Kirsti S; Svenson, Johan; Svendsen, John-Sigurd; Brandsdal, Bjørn Olav


    Many biologically active compounds bind to plasma transport proteins, and this binding can be either advantageous or disadvantageous from a drug design perspective. Human serum albumin (HSA) is one of the most important transport proteins in the cardiovascular system due to its great binding capacity and high physiological concentration. HSA has a preference for accommodating neutral lipophilic and acidic drug-like ligands, but is also surprisingly able to bind positively charged peptides. Understanding of how short cationic antimicrobial peptides interact with human serum albumin is of importance for developing such compounds into the clinics. The binding of a selection of short synthetic cationic antimicrobial peptides (CAPs) to human albumin with binding affinities in the μM range is described. Competitive isothermal titration calorimetry (ITC) and NMR WaterLOGSY experiments mapped the binding site of the CAPs to the well-known drug site II within subdomain IIIA of HSA. Thermodynamic and structural analysis revealed that the binding is exclusively driven by interactions with the hydrophobic moieties of the peptides, and is independent of the cationic residues that are vital for antimicrobial activity. Both of the hydrophobic moieties comprising the peptides were detected to interact with drug site II by NMR saturation transfer difference (STD) group epitope mapping (GEM) and INPHARMA experiments. Molecular models of the complexes between the peptides and albumin were constructed using docking experiments, and support the binding hypothesis and confirm the overall binding affinities of the CAPs. The biophysical and structural characterizations of albumin-peptide complexes reported here provide detailed insight into how albumin can bind short cationic peptides. The hydrophobic elements of the peptides studied here are responsible for the main interaction with HSA. We suggest that albumin binding should be taken into careful consideration in antimicrobial peptide

  3. Lactose binding to human galectin-7 (p53-induced gene 1) induces long-range effects through the protein resulting in increased dimer stability and evidence for positive cooperativity (United States)

    Ermakova, Elena; Miller, Michelle C; Nesmelova, Irina V; López-Merino, Lara; Berbís, Manuel Alvaro; Nesmelov, Yuri; Tkachev, Yaroslav V; Lagartera, Laura; Daragan, Vladimir A; André, Sabine; Cañada, F Javier; Jiménez-Barbero, Jesús; Solís, Dolores; Gabius, Hans-Joachim; Mayo, Kevin H


    The product of p53-induced gene 1 is a member of the galectin family, i.e., galectin-7 (Gal-7). To move beyond structural data by X-ray diffraction, we initiated the study of the lectin by nuclear magnetic resonance (NMR) and circular dichroism spectroscopies, and molecular dynamics (MD) simulations. In concert, our results indicate that lactose binding to human Gal-7 induces long-range effects (minor conformational shifts and changes in structural dynamics) throughout the protein that result in stabilization of the dimer state, with evidence for positive cooperativity. Monte Carlo fits of 15N-Gal-7 HSQC titrations with lactose using a two-site model yield K1 = 0.9 ± 0.6 × 103 M−1 and K2 = 3.4 ± 0.8 × 103 M−1. Ligand binding-induced stabilization of the Gal-7 dimer was supported by several lines of evidence: MD-based calculations of interaction energies between ligand-loaded and ligand-free states, gel filtration data and hetero-FRET spectroscopy that indicate a highly reduced tendency for dimer dissociation in the presence of lactose, CD-based thermal denaturation showing that the transition temperature of the lectin is significantly increased in the presence of lactose, and saturation transfer difference (STD) NMR using a molecular probe of the monomer state whose presence is diminished in the presence of lactose. MD simulations with the half-loaded ligand-bound state also provided insight into how allosteric signaling may occur. Overall, our results reveal long-range effects on Gal-7 structure and dynamics, which factor into entropic contributions to ligand binding and allow further comparisons with other members of the galectin family. PMID:23376190

  4. Difference and ratio plots

    DEFF Research Database (Denmark)

    Svendsen, Anders Jørgen; Holmskov, U; Bro, Peter


    hitherto unnoted differences between controls and patients with either rheumatoid arthritis or systemic lupus erythematosus. For this we use simple, but unconventional, graphic representations of the data, based on difference plots and ratio plots. Differences between patients with Burkitt's lymphoma...... and systemic lupus erythematosus from another previously published study (Macanovic, M. and Lachmann, P.J. (1979) Clin. Exp. Immunol. 38, 274) are also represented using ratio plots. Our observations indicate that analysis by regression analysis may often be misleading....

  5. Same but Different

    DEFF Research Database (Denmark)

    Hardt, Daniel; Mikkelsen, Line


    In this paper, we argue that same is fundamentally different from different, in that same imposes a discourse condition on eventualities, while different compares individuals. This difference has not been noted in previous literature. Furthermore, in the literature on same, there has been...... a persistent puzzle about the contribution of the definite article with which same must co-occur. We show that this puzzle is resolved once the contribution of same is adjusted to apply to eventualities: then the definite article can be interpreted in the usual way, as generating a presupposition about...... individuals....

  6. Estimation of BDS DCB Combining GIM and Different Zero-mean Constraints

    Directory of Open Access Journals (Sweden)

    YAO Yibin


    Full Text Available As the limited number of the BeiDou Navigation Satellite System (BDS satellites and tracking stations currently, it's difficult to attain daily DCBs solution with precisely high accuracy based on BeiDou single system. In order to overcome the weakness above, two different zero-mean constraints for BDS satellites, called constraint one and constraint two, respectively, are used to estimate DCBs of BDS based on BeiDou observations from the multi-GNSS experiment (MGEX network and global ionosphere maps (GIM from the Center for Orbit Determination in Europe (CODE. The results show that the systematic difference of the overall trend under two different constraints is consistent, and the systematic difference of DCBC2I-C7I and DCBC2I-C6I is -3.3 ns and 1.2 ns, respectively. The systematic difference between BDS satellite DCBs and receiver DCBs has the same absolute value, but opposite signs instead. Compared to constraint one, The DCBs estimation of IGSO/MEO satellites under constraint two are more stable (the improvement of satellites DCBC2I-C7I and DCBC2I-C6I STD are up to 21%, 13%, respectively, the stability of IGSO and MEO satellites (STDs are within 0.1 ns, 0.2 ns, respectively is better than that of GEO satellites (STDs are 0.15~0.32 ns. DCB estimation of constraint one is not only consistent with the CAS/DLR products (Bias:-0.4~0.2 ns, but also takes into account the stability of BDS satellites DCB. Under the two different constraints, there is no obvious change in BDS receiver DCBs, meaning that the selection of constraints has no obvious influence on the stability of BDS receivers DCBs. The overall stability of BDS receiver DCBs is better than 1 ns. Due to the accuracy discrepancy of GIM in different latitudes, the stability of BDS receiver DCBs in the middle-high latitude (STDs are within 0.4 ns is better than that in low latitude region (STDs are 0.8~1 ns.

  7. Same, but different

    DEFF Research Database (Denmark)

    Jørgensen, Christian Helms

    Historically apprenticeship has developed very differently inthe Nordic Countries, either as a separate dual system (Denmark), asan integrated part of upper secondary education (Norway) or hasalmost disappeared (Sweden). This purpose of this paper is toexamine the roots of these differences in th...

  8. Sex Differences in Pain. (United States)

    Sorge, Robert E; Totsch, Stacie K


    Females greatly outnumber males as sufferers of chronic pain. Although social and psychological factors certainly play a role in the differences in prevalence and incidence, biological differences in the functioning of the immune system likely underlie these observed effects. This Review examines the current literature on biological sex differences in the functioning of the innate and adaptive immune systems as they relate to pain experience. With rodent models, we and others have observed that male mice utilize microglia in the spinal cord to mediate pain, whereas females preferentially use T cells in a similar manner. The difference can be traced to differences in cell populations, differences in suppression by hormones, and disparate cellular responses in males and females. These sex differences also translate into human cellular responses and may be the mechanism by which the disproportionate chronic pain experience is based. Recognition of the evidence underlying sex differences in pain will guide development of treatments and provide better options for patients that are tailored to their physiology. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  9. Difference Decision Diagrams

    DEFF Research Database (Denmark)

    Moeller, Jesper; Lichtenberg, Jacob; Andersen, Henrik Reif


    This paper describes a new data structure, difference decision diagrams (DDDs), for representing a Boolean logic over inequalities of the form $x-y......This paper describes a new data structure, difference decision diagrams (DDDs), for representing a Boolean logic over inequalities of the form $x-y...

  10. Gender similarities and differences. (United States)

    Hyde, Janet Shibley


    Whether men and women are fundamentally different or similar has been debated for more than a century. This review summarizes major theories designed to explain gender differences: evolutionary theories, cognitive social learning theory, sociocultural theory, and expectancy-value theory. The gender similarities hypothesis raises the possibility of theorizing gender similarities. Statistical methods for the analysis of gender differences and similarities are reviewed, including effect sizes, meta-analysis, taxometric analysis, and equivalence testing. Then, relying mainly on evidence from meta-analyses, gender differences are reviewed in cognitive performance (e.g., math performance), personality and social behaviors (e.g., temperament, emotions, aggression, and leadership), and psychological well-being. The evidence on gender differences in variance is summarized. The final sections explore applications of intersectionality and directions for future research.

  11. Different, Unequal or Unconnected

    Directory of Open Access Journals (Sweden)

    Néstor García Canclini


    Full Text Available The author proposes three key elements for dealing with the subject of interculturality and globalisation: difference, inequality and unconnectedness. He wonders not only about how to recognise the differences or correct the inequalities, but also about how to connectthe majorities to the global networks. For this, in the first place, he situates inequality and difference, and he deals with the latter from the theorisations of ethnic studies. And, secondly, he takes up the articulation of differences and inequalities proposed by Pierre Bourdieu and modified by authors that developed different perspectives based on their initial collaboration with him, such as Claude Grignon, Jean-Claude Passeron and Luc Boltanski. Canclini isattracted by these authors’ attempts to “open up the national horizon at a time when interculturality is globalising.”

  12. The effect of four different feeding regimens from rearing period to sexual maturity on breast muscle protein turnover in broiler breeder parent stock. (United States)

    Vignale, Karen; Caldas, Justina V; England, Judy A; Boonsinchai, Nirun; Sodsee, Phiphob; Putsakum, Monticha; Pollock, Erik D; Dridi, Sami; Coon, Craig N


    A study was conducted to evaluate the effect of four different feeding regimens on breast muscle protein turnover in broiler breeder Cobb-500 parent stock (PS) pullets and breeder hens. The four feeding regimens based on BW curves utilized for the study were as follows: Everyday feeding (STD-ED) (Cobb Standard BW curve), skip-a-day feeding (STD-SKIP) (Cobb Standard BW curve), lighter BW (LBW-SKIP) (BW curve 20% under), and heavier BW (HBW-SKIP) (BW curve 20% over). Each feeding regimen was provided to pullets from 4 wk to 21 wk of age. Protein turnover was determined in PS pullets/breeders at 6, 10, 12, 16, 21, 25, 31, 37, 46, and 66 wk of age. A completely randomized design was used with a 4 × 10 factorial arrangement (four feeding regimens, 10 ages), each pullet represented a replicate. Five pullets/breeders at each age were given an intravenous flooding-dose of 15N-Phe (15N phenylalanine 150 mM, 40 APE (atom percent excess)) at a dose of 10 mL/kg BW for the determination of fractional synthesis rate (FSR). After 10 min, birds were euthanized and the breast muscle (pectoralis major) excised for protein turnover and gene expression analysis. Excreta was collected from each pullet or breeder for 3-methylhistidine (3-MH) analysis. No feeding regimen affected protein turnover. There was an age effect for breast muscle FSR. The FSR in breast muscle of pullets significantly increased from 6 wk to 12 wk and then decreased significantly for 31 wk-old breeders. FSR in breeder breast muscle increased significantly from 31 wk to 66 wk. There was an age effect for breast muscle fractional breakdown rate (FBR). FBR in breast muscle significantly increased from 21 wk to 25 wk and 31 wk (peak egg production), then significantly decreased at 66 wk. The expression of the genes related to protein degradation (Atrogin-1, MURF-1) in breast muscle was significantly higher at peak egg production. Protein turnover in skeletal muscle tissue is believed to be a source of nutrients

  13. More Similar Than Different

    DEFF Research Database (Denmark)

    Pedersen, Mogens Jin


    What role do employee features play into the success of different personnel management practices for serving high performance? Using data from a randomized survey experiment among 5,982 individuals of all ages, this article examines how gender conditions the compliance effects of different...... incentive treatments—each relating to the basic content of distinct types of personnel management practices. The findings show that males and females are more similar than different in terms of the incentive treatments’ effects: Significant average effects are found for three out of five incentive...

  14. Vector Difference Calculus (United States)

    Schwalm, W. A.; Schwalm, M. K.; Giona, M.


    Space is filled with triangulating graph \\calG to serve as a quadrature grid. A discrete analog of the theory of differential forms is constructed using the associated simplical complex. The role of a basis for Λ^p at a point is played by the set of (p+1) -simplices containing a given vertex. Vector difference operations analogous to div, grad and curl, together with corresponding vector identities and exact difference analogs of the Stokes-type theorems, are obtained in terms of the boundary partial and coboundary d. Difference versions of the full vector Maxwell electromagnetic equations are analyzed on a random structure.

  15. Inclusão da pessoa com deficiência em um Centro de Referência em DST/AIDS de um município baiano Inclusión de personas con discapacidad en un Centro de Referencia en ETS / SIDA de una ciudad de Bahía, Brasil Inclusion of persons with disabilities in a Reference Center for STD / AIDS of a town in Bahia, Brazil

    Directory of Open Access Journals (Sweden)

    Alessandra Santos Sales


    adaptación de materiales, programas y políticas públicas para lograr la inclusión equitativa y la inclusión de esta población.This qualitative study sought to ascertain the opinion of health professionals about the inclusion of people with disabilities in the activities of reception, prevention and treatment in a Reference Center for STD/AIDS. The data were submitted to Bardin's content analysis technique. The analysis showed that professionals conduct their service in the sense of inclusion, seeking ways of communication to reach these people as the use of LIBRAS, matching the physical structure, equality of attendance and understanding of the vulnerabilities of this population. Despite the great importance of strategies adopted in facilitating a friendly service to people with disabilities, those strategies leave mostly from isolated and individually activities. It is needed an effective link among the service managers and political actors in the construction and adaptation of materials, programs and public policies to achieve equitable and inclusion of this population.

  16. Gender Differences in Epilepsy

    National Research Council Canada - National Science Library

    Christensen, Jakob; Kjeldsen, Marianne Juel; Andersen, Henning; Friis, Mogens Laue; Sidenius, Per


    Purpose: The aim of this study was to look at gender differences in unselected populations of patients with epilepsy classified according to the 1989 International League Against Epilepsy (ILAE) criteria. Methods...

  17. Differences between opioids

    DEFF Research Database (Denmark)

    Drewes, Asbjørn Mohr; Jensen, Rasmus D; Møller Nielsen, Lecia


    to morphine. Although this approach is recognized as cost-effective in most cases there is solid evidence that, on an individual patient basis, opioids are not all equal. Therefore it is important to have an armamentarium of strong analgesics in clinical practice to ensure a personalized approach in patients...... who do not respond to standard treatment. In this review we highlight differences between opioids in human studies from a pharmacological, experimental, clinical and health economics point of view. We provide evidence that individuals respond differently to opioids, and that general differences......Clinical studies comparing the response and side effects of various opioids have not been able to show robust differences between drugs. Hence, recommendations of the regulatory authorities have been driven by costs with a general tendency in many countries to restrict physician's use of opioids...

  18. Differences: USA/USSR. (United States)

    Vaillant, Janet; And Others


    Presents lesson plans highlighting cultural differences between the United States and the Soviet Union. Includes background for teachers on the geography, the political system, and the economy. Student materials and suggested activities are provided. (DH)

  19. Cultural differences in risk

    Directory of Open Access Journals (Sweden)

    Do-Yeong Kim


    Full Text Available We compared South Koreans with Australians in order to characterize cultural differences in attitudes and choices regarding risk, at both the individual and group levels. Our results showed that Australians, when assessed individually, consistently self-reported higher preference for risk than South Koreans, regardless of gender. The data revealed that South Koreans, regardless of gender composition, were willing to take greater risks when making decisions in group decision-making situations than when they were alone. This is a different pattern from that seen in the Australian sample, in which a risky shift was noted only among males. This difference was attributed to the influence of various cultural orientations (independent vs. interdependent relationship styles. This study also provides a discussion of the implications of these results in terms of cultural differences in attitudes and decisions regarding risk.

  20. Different Types of Lupus (United States)

    ... Twitter Facebook Pinterest Email Print Different types of lupus Lupus Foundation of America September 18, 2017 Resource ... lupus. Learn more about each type below. Systemic lupus erythematosus Systemic lupus is the most common form ...

  1. Individual Differences: A Review (United States)


    6l6ments des tests collectifs. L’utilisation de tests A des fins de sdlection a connu la plus grande pouss~e pendant la Premi~re Guerre mondiale oil 1,7...observing times of stellar transits almost a second later than he did. As a result, Bessel developed the ’personal equation’, which referred to the...difference in seconds between estimates of two observers, and became the first researcher to record quantitative measurements of individual differences



    POPESCU Silvia


    This work presents an overview of the research on gender differences in leadership, examines the impact of sex stereotyping, looks at the organizational effects of various types of leadership, and argues for the acceptance of a diversity of non gender linked leadership styles. The topic of gender differences in leadership style has been of great interest to researchers in the fields of psychology, management, and sociology, especially in recent years, as women have begun to assume more leader...

  3. Solidarity Through Difference

    DEFF Research Database (Denmark)

    Holck, Lotte

    )equality. It is explored how diversity is linked to paradoxical processes of gendered and ethnified hierarchies based in stereotypical in- and out-groups as well as (organic) solidarity through difference. Drawing on these paradoxical processes, the analysis unfolds how equality in diverse teams might be fostered by team...... practices that stress members’ heterogeneity and avoid reducing minority members to mere representatives of a (stigmatized) social group. These are furthermore team practices that strengthening team solidarity trough openness to difference....



    Goparaju Purna SUDHAKAR


    Popularity of teams is growing in 21st Century. Organizations are getting their work done through different types of teams. Teams have proved that the collective performance is more than the sum of the individual performances. Thus, the teams have got different dimensions such as quantitative dimensions and qualitative dimensions. The Quantitative dimensions of teams such as team performance, team productivity, team innovation, team effectiveness, team efficiency, team decision making and tea...

  5. Cultural differences in use

    DEFF Research Database (Denmark)

    Jonasson, Charlotte; Lauring, Jakob


    Purpose - Purpose: Intercultural communication problems are most often argued to be caused by differences in cultural values. In this exploratory paper, we argue that attention should not only be directed at national differences. Alternatively, we argue that more interest should be paid to the ac......Purpose - Purpose: Intercultural communication problems are most often argued to be caused by differences in cultural values. In this exploratory paper, we argue that attention should not only be directed at national differences. Alternatively, we argue that more interest should be paid...... to the actual use of those differences in communication. Design/methodology/approach - Methodology: Ethnographic field study including 12 interviews and observations. Findings - Findings: We use a short case on interaction between expatriates and local managers in a Chinese subsidiary of a Danish multinational...... corporation. This illustrates how individuals and groups may essentialize cultural differences during intercultural business encounters and how this fixation of cultural traits can be used in social stratification. Originality/value - Originality: Only scant extant research has focused on the active use...

  6. Feasibility of concurrent dual contrast enhancement using CEST contrast agents and superparamagnetic iron oxide particles.

    NARCIS (Netherlands)

    Gilad, A.A.; Laarhoven, H.W.M. van; McMahon, M.T.; Walczak, P.; Heerschap, A.; Neeman, M.; Zijl, P.C. van; Bulte, J.W.


    A major challenge for cellular and molecular MRI is to study interactions between two different cell populations or biological processes. We studied the possibility to simultaneously image contrast agents based on two different MRI contrast mechanisms: chemical exchange saturation transfer (CEST)

  7. Feasibility of concurrent dual contrast enhancement using CEST contrast agents and superparamagnetic iron oxide particles

    NARCIS (Netherlands)

    Gilad, Assaf A.; van Laarhoven, Hanneke W. M.; McMahon, Michael T.; Walczak, Piotr; Heerschap, Arend; Neeman, Michal; van Zijl, Peter C. M.; Bulte, Jeff W. M.


    A major challenge for cellular and molecular MRI is to study interactions between two different cell populations or biological processes. We studied the possibility to simultaneously image contrast agents based on two different MRI contrast mechanisms: chemical exchange saturation transfer (CEST)

  8. Local vibration modes of shallow thermal donors in nitrogen-doped CZ silicon crystals

    Energy Technology Data Exchange (ETDEWEB)

    Inoue, N. [RIAST, Osaka Prefecture University, Sakai, 599-8570 (Japan) and Nitrogen Measurement WG, JEITA, Tokyo, 101-0062 (Japan)]. E-mail:; Nakatsu, M. [RIAST, Osaka Prefecture University, Sakai, 599-8570 (Japan); Ono, H. [Japan Fine Ceramics Center, Tokyo, 105-0003 (Japan); Nitrogen Measurement WG, JEITA, Tokyo, 101-0062 (Japan)


    Local vibration mode (LVM) infrared absorption from shallow thermal donors (STD) composed of nitrogen-oxygen complexes in nitrogen-doped CZ silicon crystals was examined. The samples whose STD concentration had been determined were measured. The sample dependence of the peaks at 810 and 1018cm{sup -1} was similar to that of STD but the estimated concentration was slightly higher. New LVM peaks were found at 855, 973, 982, 1002cm{sup -1} and so on. Their magnitude and sample dependence agreed well with those of STD. Annealing temperature dependence of other samples supported the results. Annealing time dependence of STD concentration at 650 deg. C was examined. STD peaks at 250, 242 and those at 240, 234 and 238cm{sup -1} behaved differently, suggesting the presence of two kinds of STD origin.

  9. Youth United through Health Education: Building Capacity through a Community Collaborative Intervention to Prevent HIV/STD in Adolescents Residing in a High STD Prevalent Neighborhood (United States)

    Sieverding, John; Boyer, Cherrie B.; Siller, Jacqueline; Gallaread, Alonzo; Krone, Melissa; Chang, Y. Jason


    The early detection and treatment of STDs is an effective strategy for slowing the sexual transmission of HIV. The goal of the YUTHE (Youth United Through Health Education) program, a collaborative effort between the San Francisco Department of Public Health (SFDPH) and the University of California, San Francisco, is to increase sexually…

  10. Globalization - Different approaches

    Directory of Open Access Journals (Sweden)

    Viorica Puscaciu


    Full Text Available In this paper we investigate the different approaches of the globalization phenomenon. Despite the geographical distancesm, the link between people are ever more strong on different ways and plans: from technology between political, economical, cultural world events, and many other aspects. So, the link between globalization and democracy, and its impact on the most important social and economic matters. We also surprise the impact of the internet revolution and its corolar e-commerce, and its consequences, sometimes unpredictible ones. Another annalysed problem is that of the governments trying, and sometimes succeeding to controll the money, products, peole and their ideas that freely move inside the national frontiers, thus going to slower or to stop the progress. Nevertheless, this global interraction between people also create phenomena of insecurity on different ways: terrorism, traffic of arms, drugs, economical aggresions causing the environment, and other inconvenient facts and situations.

  11. Envy and difference. (United States)

    West, Marcus


    This paper explores five examples of envy, examining the similarities and differences between the clinical situations. The theory relating to envy is extensively reviewed and a critique of the Kleinian position is offered, suggesting that the aversion to separation and difference is not only prior to, but also has explanatory precedence over, the functioning of envy. Kleinian examples are explored in this light. The experience of separateness and difference is understood to lead to a number of outcomes: envy, admiration, competitiveness, a sense of low self-esteem and inadequacy, or a fear of being envied. It is argued that the individual's particular personality organization and their associated relational pattern will determine their experience of envy. Examples of schizoid, borderline, narcissistic and hysteric functioning in relation to envy are examined in some depth. The link between these phenomena and the death instinct is touched on. © 2010, The Society of Analytical Psychology.

  12. Production of different literacies

    Directory of Open Access Journals (Sweden)

    João Wanderley Geraldi


    Full Text Available In this paper we question the "modern" concept of literacy, observing it as it is a new theory aiming at replacing the concept of "alphabetization" and its practices so as to produce effective ways of inserting the subject in the worlds of writing and reading. We especially employ the Bakhtinian concepts of speech genres and responsible act on concrete utterances that exemplify the current teaching practice in order to show that the key problem in education is not the name change of a teaching practice, but it is both the mixture of two different realities when it comes to different levels of literacy or to different literacies and the unequal distribution of cultural goods in society.

  13. Becoming indifferent to differences

    DEFF Research Database (Denmark)

    Hyldgaard, Kirsten


    by the implicit assumption that this issue is of universal interest and relevance. The intention of this article is to make the argument to the contrary. Tolerance implies recognition of a number of concepts such as the person, the individual, and the self which are not universally recognized. The basic argument......According to A. Badiou, the pressing question is not how we should deal with differences – celebrate, respect, tolerate or fight them – but how an event may render differences, which until now have seemed natural or self-evident, inconsequential. The current debate concerning tolerance is dominated...


    Directory of Open Access Journals (Sweden)

    Goparaju Purna SUDHAKAR


    Full Text Available Popularity ofteams is growing in 21st Century. Organizations are getting theirwork done through different types of teams. Teams have proved that thecollective performance is more than the sum of the individual performances.Thus, the teams have got different dimensions such as quantitative dimensionsand qualitative dimensions. The Quantitative dimensions of teams such as teamperformance, team productivity, team innovation, team effectiveness, teamefficiency, team decision making and team conflicts and Qualitative dimensionsof teams such as team communication, team coordination, team cooperation, teamcohesion, team climate, team creativity, team leadership and team conflictshave been discussed in this article.

  15. Differing Levels of Forestry Best Management Practices at Stream Crossing Structures Affect Sediment Delivery and Installation Costs

    Directory of Open Access Journals (Sweden)

    Brian C. Morris


    Full Text Available Forestry best management practices (BMPs are used to reduce sedimentation from forest stream crossings. Three BMP treatments (BMP−, BMP-std, and BMP+ were applied to three forest road stream crossings (bridge, culvert, and ford. BMP− did not meet existing BMP guidelines, BMP-std met standard recommendations, and BMP+ treatments exceeded recommendations. Following BMP applications, three simulated rainfall intensities (low, medium, and high were applied in order to evaluate sediment delivery from crossing type and BMP level. During rainfall simulation, sediment concentrations (mg/L were collected with automated samplers and discharge (L/s was estimated to calculate total sediment loading. Costs of stream crossings and BMP levels were also quantified. Mean sediment associated with the three stream crossings were 3.38, 1.87, and 0.64 Mg for the BMP−, BMP-std, and BMP+ levels, respectively. Ford, culvert, and bridge crossings produced 13.04, 12.95, and 0.17 Mg of sediment during construction, respectively. BMP enhancement was more critical for sediment control at the culvert and ford crossings than at the bridge. Respective costs for BMP−, BMP-std, and BMP+ levels were $5,368, $5,658, and $5,858 for the bridge; $3,568, $4,166 and $4,595 for the culvert; and $180, $420 and $1,903 for the ford. Costs and sediment values suggest that current standard BMP levels effectively reduce stream sediment while minimizing costs.

  16. Vision: The Leadership Difference. (United States)

    Browne, Elise R.


    The author states that all types of leaders share four qualities: (1) intensity of vision, (2) ability to communicate agenda, (3) conviction in their beliefs, and (4) positive self-regard. She interviews Warren Bennis, an author on this subject, about the differences between business and volunteer leaders. (CH)

  17. Everybody's Different Nobody's Perfect (United States)

    ... traten ni qué edad tengan — eso se llama “DISCAPACIDAD.” Some kids have a disability because their muscles ... have one? ¿Conoces a alguien que tenga una discapacidad? ¿Tienes una tú? Everybody’s different, nobody’s perfect. So ...

  18. Understanding Readers' Differing Understandings (United States)

    Kucer, Stephen B.


    This research examines the characteristics of reader understandings that vary from those stated in the text. Eighty-seven fourth graders orally read complex academic literary and scientific texts, followed by probed retellings. Retold ideas not directly supported by, or reflective of, the texts were identified. These differing understandings…

  19. Making Team Differences Work (United States)

    Strathman, Beth


    Most district and school leaders understand that recruiting group members who have differing backgrounds, perspectives, talents, and personalities makes for good decision-making. Unfortunately, simply assembling a variety of top-notch individuals does not necessarily mean their talents and perspectives will be fully considered. Beth Strathman…

  20. Action Learning: Cultural Differences (United States)

    Stevens, Gillian; de Vera, Manuel


    The article describes the experience of forming a set in a higher education institution and offers some observations and insights gained from the perspectives of the role of the set adviser, cultural differences and the challenges of attempting to align theory, practice and experience.

  1. Difference Discrete Variational Principles (United States)

    Baleanu, Dumitru; Jarad, Fahd


    The paper provides the discrete Lagrangian and Hamiltonian formulations of mechanical systems for both non-singular and singular cases. The Lagrangians with linear velocities and with higher velocities are investigated and the corresponding difference Euler-Lagrange equations and Hamiltonians are found.

  2. Is China Different?

    DEFF Research Database (Denmark)

    Ljungwall, Christer; Tingvall, Patrik Gustavsson

    We examine whether China has benefited more than other countries from financial sector development by performing a meta-analysis of the relevant literature covering a large number of countries at different stages of development. Although the results for China are inconclusive, they indicate...

  3. Same, but Different

    DEFF Research Database (Denmark)

    Jørgensen, Christian Helms; Michelsen, Svein; Olofsson, Jonas


    Historically, apprenticeship has developed very differently in the three Nordic Countries, Denmark, Norway and Sweden, either as a dual system in a separate track (Denmark), as an integrated part of upper secondary education (Norway) or has almost disappeared (Sweden). The purpose of this chapter...

  4. Media Differences in Communication

    NARCIS (Netherlands)

    Raine, Roxanne B.; Raine, Roxanne B.; Esposito, A.; Campbell, N.; Vogel, C.; Hussain, A.; Nijholt, Antinus


    With the ever-growing ubiquity of computer-mediated communication, the application of language research to computer-mediated environments becomes increasingly relevant. How do overhearer effects, discourse markers, differences for monologues and dialogues, and other verbal findings transmute in the

  5. A Different Perspective

    Indian Academy of Sciences (India)

    BOOK REVIEW. A Different Perspective. Sushan Konar. An Introductory Course of Statistical. Mechanics. Palash B Pal. Narosa Publishing. Pages: 394, 2008, Price:| 334. An Introductory Course of Statistical Me- chanics [1] is a pedagogic textbook primarily meant for graduate and advanced undergradu- ate physics students ...

  6. Similarity or difference?

    DEFF Research Database (Denmark)

    Villadsen, Anders Ryom


    While the organizational structures and strategies of public organizations have attracted substantial research attention among public management scholars, little research has explored how these organizational core dimensions are interconnected and influenced by pressures for similarity....... In this paper I address this topic by exploring the relation between expenditure strategy isomorphism and structure isomorphism in Danish municipalities. Different literatures suggest that organizations exist in concurrent pressures for being similar to and different from other organizations in their field...... of action. It is theorized that to meet this challenge organizations may substitute increased similarity on one core dimension for increased idiosyncrasy on another, but only after a certain level of isomorphism is reached. Results of quantitative analyses support this theory and show that an inverse U...

  7. Different way, same goal

    CERN Multimedia

    Antonella Del Rosso & Fabio Capello


    Radio-oncologists and radiotherapists represented a large proportion of the doctors and clinicians who attended the ICTR-PHE 2012 conference. With them were also biologists and doctors of nuclear medicine. They presented the state of the art of their research that touches on the genetics and biology of tumours as well as on futuristic drugs that selectively target malignant cells. The future of cancer treatment seems to lie in the personalised approach.   When the members of the life sciences community took over from the physicists, the focus remained basically the same. Just another sign of the fact that the different communities are leading the same battle and have the same goal. However, the methodologies and issues can be very different. The example of hadrontherapy illustrates the situation well: while for physicists this is a relatively well-established concept, medical doctors consider that the amount of patient data available is still very small. Several clinical trials are in progress ...

  8. More Really is Different


    Gu, Mile; Weedbrook, Christian; Perales, Alvaro; Nielsen, Michael A.


    In 1972, P.W.Anderson suggested that `More is Different', meaning that complex physical systems may exhibit behavior that cannot be understood only in terms of the laws governing their microscopic constituents. We strengthen this claim by proving that many macroscopic observable properties of a simple class of physical systems (the infinite periodic Ising lattice) cannot in general be derived from a microscopic description. This provides evidence that emergent behavior occurs in such systems,...

  9. Differences in smartphone usage

    DEFF Research Database (Denmark)

    Gustarini, Mattia; Scipioni, Marcello Paolo; Fanourakis, Marios


    We analyze the users’ intimacy to investigate the differences in smartphone usage, considering the user’s location and number and kind of people physically around the user. With a first user study we (1) validate the intimacy concept, (2) evaluate its correlation to smartphone usage features and (3......-time features are predictive for the intimacy, and other smartphone-based features can improve the intimacy prediction accuracy....

  10. Risk factors in ectopic pregnancy and differences between adults and adolescents, is consanguinity important? (United States)

    Kashanian, Maryam; Baradaran, Hamid Reza; Mousavi, Seyede Somayeh; Sheikhansari, Narges; BararPour, Foroozan


    The aim of the study was to determine the risk factors of ectopic pregnancy (EP) and to compare them between women over and under 20 years of age. 308 cases of EP (case group) were compared with 616 cases of normal pregnancy. Smoking [Ad OR =5.7 (CI 95%=2.8-11.6), p 20-year-old group. Negative Rh [p = 0.02], good economic status [p = 0.000] and prior STD [p = 0.03] were more common in Afghan women. However, previous caesarean delivery [p = 0.04] was more in Iranian women. Smoking, previous EP, history of STD, IUD, infertility, previous caesarean delivery and consanguinity are all risk factors for EP.

  11. The Disavowal of Difference

    DEFF Research Database (Denmark)

    Faber, Stine Thidemann


    -identification, processes of moral judgments, revealed in statements about ‘others’, underlines distinctions that are about class. The article discusses different aspects of accessing class by way of interviews (thereby privileging ‘talk’ as a source of data), the dilemmas involved in conducting the interviews (including......In this article the author recounts and reflects upon methodological issues raised in research about class representations and symbolic boundary drawing in face-to-face interview encounters. Although explicit class categories are avoided among the interviewees, particularly for self...

  12. Smart devices are different

    DEFF Research Database (Denmark)

    Stisen, Allan; Blunck, Henrik; Bhattacharya, Sourav


    research results. This is due to variations in training and test device hardware and their operating system characteristics among others. In this paper, we systematically investigate sensor-, device- and workload-specific heterogeneities using 36 smartphones and smartwatches, consisting of 13 different......The widespread presence of motion sensors on users' personal mobile devices has spawned a growing research interest in human activity recognition (HAR). However, when deployed at a large-scale, e.g., on multiple devices, the performance of a HAR system is often significantly lower than in reported...

  13. Is China Different?

    DEFF Research Database (Denmark)

    Ljungwall, Christer; Tingvall, Patrik Gustavsson


    In this paper we examine whether China has benefited more from spending on R&D than other countries by conducting a meta-analysis of the relevant literature on a large number of countries at different stages of economic development. The results suggest that the growth-enhancing effect of R......&D spending in China has been significantly weaker than that of other countries. It is thus unlikely that R&D spending has been successful as a key contributing factor to economic growth in China....

  14. Is China Different?

    DEFF Research Database (Denmark)

    Ljungwall, Christer; Tingvall, Patrik Gustavsson

    In this paper we examine whether China has benefited more from spending on R&D than other countries by conducting a meta-analysis of the relevant literature on a large number of countries at different stages of economic development. The results suggest that the growth-enhancing effect of R......&D spending in China has been significantly weaker than that of other countries. It is thus unlikely that R&D spending has been successful as a key contributing factor to economic growth in China....

  15. Pressure difference receiving ears

    DEFF Research Database (Denmark)

    Michelsen, Axel; Larsen, Ole Næsbye


    waves behave in the air spaces leading to the interior surfaces of eardrums. A linear mathematical model with well-defined inputs is used for exploring how the directionality varies with the binaural directional cues and the amplitude and phase gain of the sound pathway to the inner surface...... of such pressure difference receiving ears have been hampered by lack of suitable experimental methods. In this review, we review the methods for collecting reliable data on the binaural directional cues at the eardrums, on how the eardrum vibrations depend on the direction of sound incidence, and on how sound...

  16. Model-independent differences

    DEFF Research Database (Denmark)

    Könemann, Patrick


    is fundamentally different. This paper reports on our ongoing work on model-independent diffs, i.e. a diff that does not directly refer to the models it was created from. Based on that, we present an idea of how the diff could be generalized, e.g. many atomic diffs are merged to a new, generalized diff. One use...... of these concepts could be a patch for models as it already exists for text files. The advantage of such a generalized diff compared to dasianormalpsila diffs is that it is applicable to a higher variety of models....

  17. The Italian Difference

    Directory of Open Access Journals (Sweden)

    Antonio Negri


    Full Text Available This pamphlet casts a polemical eye on the panorama of twentieth-century Italian philosophical culture and declares that only three figures stand as exceptions to a pervasive political and intellectual capitulation: Antonio Gramsci, Mario Tronti and Luisa Muraro. Negri argues that the two key post-war contributions to an Italian political ontology, the workerism of Tronti and the feminism of Muraro, start from the identification of the principal forms of exploitation, capitalism and patriarchy, to develop a potent thinking of singularity and creative difference. He concludes that they provide the basis for a political philosophy of the multitude that can at last move beyond postmodernity.

  18. Sexuality: differences, rights, rappresentations

    Directory of Open Access Journals (Sweden)

    Adalgiso Amendola


    Full Text Available These pages describe some of the most important questions of the historical and cultural interpretation of the information about sexuality. The discussion about homosexuality, in particular, stands out. It reconstructs the historical path of the homosexuality presence in society and in popular culture, avoiding the current  exaltation of the freedom of the pagans rather than Christians. The essays collected here pose well in evidence as the path of the idea of "naturalness" or otherwise of unnatural perversion was not at all linear but, on the other hand, wavering. Perhaps more linear, although complex from a theoretical point of view as well as political, was the path of emancipatory movements in the contemporary world. They are the expression of diversity within them. After the generation of the early years that claimed the right to the simple recognition of differences, was followed by that who played a critical eye the same naturalness of the entire sexual spectrum. Therefore gender studies, insisting on the difference between gender and sex, have always understood the “genre” as a cultural and social construction, and have even, denied the same naturalness of a concept like sex. It follows from this setup, the centrality of the study on subjectivity, also expressed through the arts.

  19. Same Traits, Different Variance

    Directory of Open Access Journals (Sweden)

    Jamie S. Churchyard


    Full Text Available Personality trait questionnaires are regularly used in individual differences research to examine personality scores between participants, although trait researchers tend to place little value on intra-individual variation in item ratings within a measured trait. The few studies that examine variability indices have not considered how they are related to a selection of psychological outcomes, so we recruited 160 participants (age M = 24.16, SD = 9.54 who completed the IPIP-HEXACO personality questionnaire and several outcome measures. Heterogenous within-subject differences in item ratings were found for every trait/facet measured, with measurement error that remained stable across the questionnaire. Within-subject standard deviations, calculated as measures of individual variation in specific item ratings within a trait/facet, were related to outcomes including life satisfaction and depression. This suggests these indices represent valid constructs of variability, and that researchers administering behavior statement trait questionnaires with outcome measures should also apply item-level variability indices.

  20. [Gender differences in depression]. (United States)

    Karger, A


    Depression is one of the most prevalent and debilitating diseases. In recent years there has been increased awareness of sex- and gender-specific issues in depression. This narrative review presents and discusses differences in prevalence, symptom profile, age at onset and course, comorbidity, biological and psychosocial factors, the impact of sexual stereotyping, help-seeking, emotion regulation and doctor-patient communication. Typically, women are diagnosed with depression twice as often as men, and their disease follows a more chronic course. Comorbid anxiety is more prevalent in women, whereas comorbid alcohol abuse is a major concern in men. Sucide rates for men are between three and five times higher compared with women. Although there are different symptom profiles in men and women, it is difficult to define a gender-specific symptom profile. Socially mediated gender roles have a significant impact on psychosocial factors associated with risk, sickness behavior and coping strategies. In general, too little attention has been paid to the definition and handling of depression and the gender-related requirements it makes on the healthcare system.

  1. Resolving inventory differences

    Energy Technology Data Exchange (ETDEWEB)

    Weber, J.H.; Clark, J.P.


    Determining the cause of an inventory difference (ID) that exceeds warning or alarm limits should not only involve investigation into measurement methods and reexamination of the model assumptions used in the calculation of the limits, but also result in corrective actions that improve the quality of the accountability measurements. An example illustrating methods used by Savannah River Site (SRS) personnel to resolve an ID is presented that may be useful to other facilities faced with a similar problem. After first determining that no theft or diversion of material occurred and correcting any accountability calculation errors, investigation into the IDs focused on volume and analytical measurements, limit of error of inventory difference (LEID) modeling assumptions, and changes in the measurement procedures and methods prior to the alarm. There had been a gradual gain trend in IDs prior to the alarm which was reversed by the alarm inventory. The majority of the NM in the facility was stored in four large tanks which helped identify causes for the alarm. The investigation, while indicating no diversion or theft, resulted in changes in the analytical method and in improvements in the measurement and accountability that produced a 67% improvement in the LEID.


    Directory of Open Access Journals (Sweden)



    Full Text Available This study of female entrepreneurship traditionally has been inspired by gender equality issues. Female entrepreneurs were assumed to experience gender-related discrimination and to experience more difficulties when starting up and running a business than their male counterparts. Today research and policy have been more and more fuelled by the idea that female entrepreneurs are important for economic progress. Even when issues such as barriers and obstacles to female entrepreneurs are raised in the gender and entrepreneurship debate, this is usually done from the perspective that female entrepreneurs are an untapped resource and have potential to contribute to a country’s economic performance. Indeed, although gender equality is one of the arguments underlying the support for female entrepreneurs within the European Union, the argument that female entrepreneurs (have the potential tocontribute to economic performance continues to play a role here. The global growth of female entrepreneurship in the last decades has been accompanied by an increase in the number of studies on female entrepreneurship. Unlike most existing studies, which focus primarily upon female entrepreneurship in Western European countries, the present thesis investigates gender differences in entrepreneurship in the Eastern European countries. Different aspects of entrepreneurship are studied including the individual, the organization and the environment. A systematic distinction is made between direct and indirect gender effects on entrepreneurship to be able to disentangle ‘pure’ gender effects from effects of factors that are correlated with gender.

  3. Creativity out of difference

    DEFF Research Database (Denmark)

    Glaveanu, Vlad Petre; Gillespie, Alex

    Human creativity is ubiquitous, occurring in everyday actions and interactions. Accordingly, we suggest, it must be grounded in the most basic processes of human symbolic activity. This presentation seeks to identify the roots of human creativity in the most fundamental cultural psychological...... processes of semiotically mediated activity. Starting with the mediational pyramid of self-other-object-sign, we suggest that creativity arises out of two disjunctions, differences or ‘gaps.’ First there is always a gap between representation, the sign, and the world, or what is signified. Action is guided...... to creativity, we argue, is not any particular ‘gap’ but rather the more dynamic movement between these psychological orientations....

  4. Difference, Power and, Redistribution

    DEFF Research Database (Denmark)

    Frederiksen, Morten

    perceived as structures of domination and expressions of emancipating modernisation. Welfare states are perceived as both structures of democratic redistribution and as power based resource appropriation. Finally welfare states are perceived as normative structures and institutions. Pierre Bourdieu's theory......  Abstract This paper addresses the issue of transposing Bourdieu to France to other nations. It is claimed that such transpositions often are characterised by the adaptation of object to methodology rather than the other way around. Departing from the Danish experience, the paper takes...... the universal welfare state as a structure of social space very different from the setting of France. It is argued that engaging such a case may show new path of analysis fruitful to the Bourdieusian perspective. Three central themes in sociology of welfare states are identified. Welfare states are both...

  5. Similar or different?

    DEFF Research Database (Denmark)

    Cornér, Solveig; Pyhältö, Kirsi; Peltonen, Jouni


    experienced by PhD students within the same discipline. This study explores the support experiences of 381 PhD students within the humanities and social sciences from three research-intensive universities in Denmark (n=145) and Finland (n=236). The mixed methods design was utilized. The data were collected...... counter partners, whereas the Finnish students perceived lower levels of instrumental support than the Danish students. The findings imply that seemingly similar contexts hold valid differences in experienced social support and educational strategies at the PhD level.......Previous research has identified researcher community and supervisory support as key determinants of the doctoral journey contributing to students’ persistence and robustness. However, we still know little about cross-cultural variation in the researcher community and supervisory support...

  6. Difference and disclosure

    DEFF Research Database (Denmark)

    Korsgaard, Morten Timmermann

    The aim of the present paper will be to engage the concept of inclusion and inclusive education through an interpretation of the political and educational writings of Hannah Arendt. Arendt’s view on the conditions of human beings seems to offer a singular and valuable starting point...... of sameness that seems aptly suited for an educational and philosophical perspective on inclusion....... for such an endeavor, since she unfolds a theory that has as its primary premises the existing together of identities that are in essence both the same and unique. This concept of plurality as a human condition thus offers a line of thought which on the one hand values difference and on the other offers an account...

  7. Children of Different Categories

    DEFF Research Database (Denmark)

    Gulløv, Eva; Bundgaard, Helle


    In this article we discuss the production of social distinctions within an institutional setting. Based on ethnographic fieldwork in a multi-ethnic pre-school in Denmark we focus on the interpersonal encounters between immigrant children, their parents and the staff. More specifically we explore...... an apparent paradox in daily practice where on the one hand staff attempt to mute differences between children on the assumption that all children are equal and should be treated as such, while on the other hand distinctions are in practice established when children behave in ways considered inappropriate...... in relation to their own long term interest. Our material indicates that this logic systematically marks Middle Eastern children as ?other?. This legitimises an educational effort to compensate practices of upbringing in the families by teaching these children how to behave in ways considered 'proper...

  8. Differing antidepressant maintenance methodologies. (United States)

    Safer, Daniel J


    The principle evidence that antidepressant medication (ADM) is an effective maintenance treatment for adults with major depressive disorder (MDD) is from placebo substitution trials. These trials enter responders from ADM efficacy trials into randomized, double-blind placebo-controlled (RDBPC) effectiveness trials to measure the rate of MDD relapse over time. However, other randomized maintenance trial methodologies merit consideration and comparison. A systematic review of ADM randomized maintenance trials included research reports from multiple databases. Relapse rate was the main effectiveness outcome assessed. Five ADM randomized maintenance methodologies for MDD responders are described and compared for outcome. These effectiveness trials include: placebo-substitution, ADM/placebo extension, ADM extension, ADM vs. psychotherapy, and treatment as usual. The placebo-substitution trials for those abruptly switched to placebo resulted in unusually high (46%) rates of relapse over 6-12months, twice the continuing ADM rate. These trials were characterized by selective screening, high attrition, an anxious anticipation of a switch to placebo, and a risk of drug withdrawal symptoms. Selectively screened ADM efficacy responders who entered into 4-12month extension trials experienced relapse rates averaging ~10% with a low attrition rate. Non-industry sponsored randomized trials of adults with multiple prior MDD episodes who were treated with ADM maintenance for 1-2years experienced relapse rates averaging 40%. Placebo substitution trial methodology represents only one approach to assess ADM maintenance. Antidepressant maintenance research for adults with MDD should be evaluated for industry sponsorship, attrition, the impact of the switch to placebo, and major relapse differences in MDD subpopulations. Copyright © 2017. Published by Elsevier Inc.

  9. Teaching Science differently (United States)

    Collery, Véronique


    Using different kind of activities is a good way to motivate students. Depending on the class i suggest them to carry out experiments and write a report of them, to prepare a video (about 3 minutes long) presenting some experiments on a theme they choose among selected topics (working in groups of 2 or 3), to do an oral presentation, to debate on a topic, to participate in scientific breakfast/tea-time. The scientific breakfast or tea-time is an opportunity for students to meet great researchers and to exchange with them friendly sharing a breakfast or a tea-time. For example, to prepare the video, the lesson consists of three steps for a total length of three or four hours.The first step is the selection of the theme and the selection of 2 or 3 impressive, funny, original, visual experiments. The second step is trying out the experiments and the writing of the script. The third step is the making of the video. During the last step the students are supposed to watch and to grade the video. For example, to impulse a debate in a class of 16-year-old students I use a part of the movie 'Appolo 13' (chapter 28). This activity is a new approach of the theme 'the gravitational force' the students learnt in their Physic's curriculum. It's a quite difficult phenomenon to visualize. The lesson consists of three steps for a total length of two hours. During the pre-task phase, students are supposed to do a matching activity to introduce scientific words and their definitions. In the task phase, an extract of the movie APOLLO 13 is shown in order to stimulate students' listening and comprehension. To help them exchange around gravity, and space flights, students are engaged in a CLIL game. In the post-task phase, the pairs join together to form 2 groups. These groups correspond the two options the controllers in Houston make to get the astronauts back home safely. A debate is requested to argue each point of view.

  10. 76 FR 66721 - CDC/HRSA Advisory Committee on HIV and STD Prevention and Treatment (United States)


    ... Prevention and Treatment In accordance with section l0(a)(2) of the Federal Advisory Committee Act (Pub. L... and control of HIV/AIDS and other STDs, the support of health care services to persons living with HIV/AIDS, and education of health professionals and the public about HIV/AIDS and other STDs. Matters To Be...

  11. NASA-STD-(I)-6016, Standard Materials and Processes Requirements for Spacecraft (United States)

    Pedley, Michael; Griffin, Dennis


    This document is directed toward Materials and Processes (M&P) used in the design, fabrication, and testing of flight components for all NASA manned, unmanned, robotic, launch vehicle, lander, in-space and surface systems, and spacecraft program/project hardware elements. All flight hardware is covered by the M&P requirements of this document, including vendor designed, off-the-shelf, and vendor furnished items. Materials and processes used in interfacing ground support equipment (GSE); test equipment; hardware processing equipment; hardware packaging; and hardware shipment shall be controlled to prevent damage to or contamination of flight hardware.

  12. NASA-STD-6016 Standard Materials and Processes Requirements for Spacecraft (United States)

    Hirsch, David B.


    The standards for materials and processes surrounding spacecraft are discussed. Presentation focused on minimum requirements for Materials and Processes (M&P) used in design, fabrication, and testing of flight components for NASA manned, unmanned, robotic, launch vehicle, lander, in-space and surface systems, and spacecraft program/project hardware elements.Included is information on flammability, offgassing, compatibility requirements, and processes; both metallic and non-metallic materials are mentioned.

  13. Validity of scales measuring the psychosocial determinants of HIV/STD-related risk behavior in adolescents. (United States)

    Basen-Engquist, K; Mâsse, L C; Coyle, K; Kirby, D; Parcel, G S; Banspach, S; Nodora, J


    We examined the content, construct and concurrent validity of scales to assess beliefs and self-efficacy related to adolescents' sexual risk behavior. We addressed content validity in the scale development process by drawing on literature and theory, and by pre-testing items with focus groups. We used confirmatory factor analysis of two models, an intercourse involvement model and a condom use model, to assess construct validity. The final intercourse involvement model included three scales: norms about sexual intercourse, attitudes about sexual intercourse and self-efficacy in refusing sex. The final condom use model included five scales: norms about condoms, attitudes about condom use, self-efficacy in communicating about condoms, self-efficacy in buying/using condoms and barriers to condom use. After two alterations to the models, the chi 2 and other indices indicated that the data fit the models well. Supporting the concurrent validity of the scales, high school students who had never had sexual intercourse had more negative attitudes toward sexual intercourse among teenagers, perceived norms toward sexual intercourse among teenagers to be more negative and expressed greater self-efficacy in refusing sex than did those who had experienced sexual intercourse. Consistent condom users had more positive attitudes and norms about condoms, had higher self-efficacy in communicating about and buying/using condoms, and perceived fewer barriers to condom purchase and use than did inconsistent condom users.

  14. How Can Men Reduce the Risk of Getting a Sexually Transmitted Disease (STD)? (United States)

    ... NICHD Research Information Find a Study More Information Pharmacology Condition Information NICHD Research Information Find a Study ... National Center for Medical Rehabilitation Research (NCMRR) Center History Funding Opportunity Announcements (FOAs) for NCMRR Partners Training & ...

  15. Sources of information, experiences and opinions on sexuality, contraception and STD protection among young Swedish students. (United States)

    Persson, E; Sandström, B; Jarlbro, G


    The aim of the investigation was to study sources of information on sexuality, contraceptives and STDs among young people as well as their experiences of and opinions on the matter. A questionnaire was distributed to 192 high-school pupils in the Stockholm area. The mean age of the participants was 17.4 years. The majority stated that school teachers and individual reading are the best sources of information. Female students more often relied on friends and family members than male students. Among those who had had their sexual debut, many stated that condom use was hard to practice.

  16. Alternate Material Pallet, 40" x 48", MIL-STD-1660, Engineering Evaluation Tests

    National Research Council Canada - National Science Library

    Dugan, Jeffery


    .... The Test Unit had a total test weight of 3,900 pounds. The plan was to test the Test Unit by accomplishing the stacking, vibration, drop, incline impact, sling compatibility, forklift handling, and disassembly tests...

  17. Space and Missile Systems Center Tailoring: Tailoring Instructions for MIL-STD-882E (United States)


    Reports. l. AFSPCMAN 91-710, Range Safety User Requirements Manual – Range Safety Policies and Procedures. m. EWR 127-1, Eastern and Western Ranges...AFSPCMAN - Air Force Space Command Manual EWR – Eastern Western Range RCC – Range Commanders Council SMC - Space and Missile Systems Center

  18. Reducing STD/HIV Stigmatizing Attitudes through Community Popular Opinion Leaders in Chinese Markets (United States)

    Rice, Ronald E.; Wu, Zunyou; Li, Li; Detels, Roger; Rotheram-Borus, Mary J.


    Reducing STDs and HIV/AIDS incidence requires campaigns designed to change knowledge, attitudes, and practices of risky sexual behavior. In China, a significant obstacle to such changes is the stigma associated with these diseases. Thus 1 campaign intervention strategy is to train credible community leaders to discuss these issues in everyday…

  19. Task Report MIL-STD-1553B Data Bus Audio Intercom System. (United States)


    modulator and the digital information is retransformed into audi- ble information by a CVSD demodulator. The operating prir.: iples of the CVSD and...AIRESEARC9I MAN4UFACTURING COMPANY ___________Of CALIFORNIA UNU 34- cm M c L L Nx UN 4- Xu tL xw ac 0 0) L) _ _ V) C4I- 4A 80!  L I~ I A~S( ACN

  20. Contraceptive Needs and Practices among Women Attending an Inner-City STD Clinic. (United States)

    Upchurch, Dawn; And Others


    To assess the need, interest in, and benefits of contraception services, 516 women at high risk for sexually transmitted diseases (STDs) were surveyed. Forty-six percent were not using contraception, but 62 percent expressed interest in contraception. Provision of the services may address the dual need for preventing unwanted pregnancies and STDs.…

  1. Impact of Sexuality Education in Preventing STD-HIV/AIDS among Teenagers of School Going Students (United States)

    Rajbhandari, Mani Man Singh


    The pivotal issue in today's world talks about HIV/AIDS transmission, it is also understood by virtue that almost every one has the knowledge of the disease and are aware how it is transmitted to others. Despite such understanding, the numbers of infected people are increasing everyday in all part of the world. The drastic scenario of developing…

  2. An Investigation of the Validity of Applying MIL-STD-285 to EMP shielding Effectiveness. (United States)


    CONTROLLING OFFICE N AME AND ADDRESS Director 1.ý/415 ApM7 Defense Nuclear Agency 13. NUMBFR OF PAGES’.- Nqr-jWashington, D.C. 20305 52 ~J)J-Y. 14...accordingly. Another 80 dB of shielding r’ffectiveness was added I by the use of interno . shield enclosures, thus reducing the interior fields by an addition

  3. MIL-STD-2411-1 Change 3. Notice Impacts to NAVAIR (United States)


    Caveat applied to NATO Top Secret) CN Critical Nuclear Weapon Design Information/DoD directive 5210.2 applies (CNWDI) CR Cryptographic ( CRYPTO ) OR...RPF products. Attr ID Attribute Description Number of Parameters 1 Currency Date 1 2 Production Date 1 3 Significant Date 1 4 Map/Chart...above and currently registered for RPF products. Currency Date (ID ::= 1) Parameter ID 1 Description Parameter Name Currency

  4. Human Factors Engineering Program for Intercontinental Ballistic Missile Systems, (MIL-STD-1794(USAF)) (United States)


    screws# bolts , or other fasteners, requiring more than 14 Kom (10 lb-ft) torque. When external wrenching fasteners cannot meet the mechanical function...H 0i 9199111 0036297 3" t muL-ffrD-1it4 ( uSAin "APPINDI A 0 Colors display coding Task 207 39 Confirm 3.1.2 3 Connectors Task 20? 3? Contract data

  5. The Different Benefits from Different Gestures in Understanding a Concept (United States)

    Kang, Seokmin; Hallman, Gregory L.; Son, Lisa K.; Black, John B.


    Explanations are typically accompanied by hand gestures. While research has shown that gestures can help learners understand a particular concept, different learning effects in different types of gesture have been less understood. To address the issues above, the current study focused on whether different types of gestures lead to different levels…

  6. Gender difference in the characteristics of and high-risk behaviours among non-injecting heterosexual methamphetamine users in Qingdao, Shandong Province, China

    Directory of Open Access Journals (Sweden)

    Liu Dianchang


    Full Text Available Abstract Background Despite the increasing risk of HIV infections, few studies concerning the characteristics of non-injecting heterosexual methamphetamine (MA users and related risk behaviours have been conducted in China. Methods Gender differences in socio-demographic characteristics, perception of MA and STD/HIV, MA use practices, and sexual behaviours related to MA use were examined among 398 non-injecting heterosexual MA users (288 males, 110 females. Results Male MA users were more likely to be married, local, and self-employed; female MA users were more likely to be young, single, engaged in commercial service or unemployed. Female MA users usually start MA use at an earlier age than males (24.3 vs. 31.3 years old, with shorter abuse durations (2.6 vs. 2.9 years, higher frequency of MA use (3.6 vs. 2.4 times per week, and higher likelihood of using MA with heterosexual partners (100% vs. 78.1%. More male MA users have had multiple sex partners (96.9% vs. 77.3% and sex exchanges (72.9% vs. 46.4%. Among 277 males who had had sex with commercial sex workers (CSW, 69.4% never used condoms, and among 77 males who had had sex with multiple partners who are commercial sex workers and always or usually used condoms, 87.0% never changed condoms when changing partners. Conclusion There may be gender difference in the characteristics of high-risk behaviours among non-injecting heterosexual MA users. The findings suggest the integration of specific risk reduction strategies into intervention programs for non-injecting heterosexual MA user populations may significantly improve program goals.

  7. Component analysis with different sets of constraints on different dimensions

    NARCIS (Netherlands)

    Takane, Yoshio; Kiers, Henk A.L.; de Leeuw, J.

    Many of the ''classical'' multivariate data analysis and multidimensional scaling techniques call far approximations by lower dimensional configurations. A model is proposed, in which different sets of linear constraints are imposed on different dimensions in component analysis and ''classical''

  8. Perception of Aesthetics by Different Professionals of Different Communities (United States)

    Vadgaonkar, Vaishali Devidas; Deshpande, Kiran Jayant; Gangurde, Parag Vishnu


    Aim To evaluate the perception of aesthetics by different professionals of different communities in India by a photographic study. Materials and Methods This was a photographic study conducted among different professionals of different communities to establish an aesthetic norm for Indian population. The communities to which the professionals belonged were North Indian, South Indian, Maharashtrian, Gujarati and Parsi. The subjects photographed were aesthetic profiles with good occlusion. Five different facial photographic views each for male and female were obtained. These photographs were then subjected to changes in increments of 2 mm and 4 mm in retrusive and protrusive profile in Adobe Photoshop CS5 after which they were evaluated by different professionals of different communities according to their preference from most liked to least liked. Results The aesthetic preferences differed widely among different professionals of different community. Conclusion The established aesthetic norms can be utilized by the dental fraternity in general and Orthodontist’s in particular in diagnosis and treatment planning of Samples belonging to different communities to have the treatment outcome in unison with the established soft tissue norm for that particular community. PMID:26557609

  9. Cultural Differences and Institutional Integration

    National Research Council Canada - National Science Library

    Guiso, Luigi; Herrera, Helios; Morelli, Massimo

    If citizens of different countries belonging to an economic union adhere to different and deeply rooted cultural norms, when these countries interact they may find it impossible to agree on efficient...


    National Research Council Canada - National Science Library

    Angelica-Nicoleta NECULĂESEI (ONEA)


    .... The same applies in the case of assigned/assumed roles in society based on gender. Cultural dimensions that reflect differences in gender roles, but also elements related to the ethics of sexual difference were highlighted by many researchers...

  11. Investigating Gender Differences in Reading (United States)

    Logan, Sarah; Johnston, Rhona


    Girls consistently outperform boys on tests of reading comprehension, although the reason for this is not clear. In this review, differences between boys and girls in areas relating to reading will be investigated as possible explanations for consistent gender differences in reading attainment. The review will examine gender differences within the…

  12. Cultural differences in learning approaches

    NARCIS (Netherlands)

    Tempelaar, D.T.; Rienties, B.C.; Giesbers, S.J.H.; Schim van der Loeff, S.; Van den Bossche, P.; Gijselaers, W.H.; Milter, R.G.


    Cultural differences in learning-related dispositions are investigated amongst 7,300 first year students from 81 different nationalities, using the framework of Hofstede (Culture’s consequences: international differences in work-related values. Sage, Beverly Hills, 1980). Comparing levels and

  13. Individual Differences in Equity Models (United States)

    Hofmans, Joeri


    In the present paper, we (1) study whether people differ in the equity models they use, and (2) test whether individual differences in equity models relate to individual differences in equity sensitivity. To achieve this goal, an Information Integration experiment was performed in which participants were given information on the performance of two…

  14. Exaggerating Accessible Differences: When Gender Stereotypes Overestimate Actual Group Differences. (United States)

    Eyal, Tal; Epley, Nicholas


    Stereotypes are often presumed to exaggerate group differences, but empirical evidence is mixed. We suggest exaggeration is moderated by the accessibility of specific stereotype content. In particular, because the most accessible stereotype contents are attributes perceived to differ between groups, those attributes are most likely to exaggerate actual group differences due to regression to the mean. We tested this hypothesis using a highly accessible gender stereotype: that women are more socially sensitive than men. We confirmed that the most accessible stereotype content involves attributes perceived to differ between groups (pretest), and that these stereotypes contain some accuracy but significantly exaggerate actual gender differences (Experiment 1). We observe less exaggeration when judging less accessible stereotype content (Experiment 2), or when judging individual men and women (Experiment 3). Considering the accessibility of specific stereotype content may explain when stereotypes exaggerate actual group differences and when they do not.

  15. Sex Differences in Drug Abuse (United States)

    Becker, Jill B.; Hu, Ming


    Sex differences are present for all of the phases of drug abuse (initiation, escalation of use, addiction, and relapse following abstinence). While there are some differences among specific classes of abused drugs, the general pattern of sex differences is the same for all drugs of abuse. Females begin regularly self-administering licit and illicit drugs of abuse at lower doses than do males, use escalates more rapidly to addiction, and females are at greater risk for relapse following abstinence. In this review, sex differences in drug abuse are discussed for humans and in animal models. The possible neuroendocrine mechanisms mediating these sex differences are discussed. PMID:17904621

  16. Managing Generational Differences in Radiology. (United States)

    Eastland, Robin; Clark, Kevin R


    Diversity can take many forms. One type of recent focus is generational differences and intergenerational issues. Much research exists regarding generational differences in the workplace and in healthcare as a whole. Very little has been done on generational differences within the field of radiology. An analysis of current research of generational differences within radiology, nursing, and healthcart in general was performed to identify current trends and establish similarities and discordance in available studies. An emphasis was placed on how generational differences influence education, teamwork, and patient care, along with what challenges and opportunities exist for managers, leaders, and organizations.

  17. Color differences without probit analysis (United States)

    Moroney, Nathan


    Color science generally considers color differences from the standpoint of distance metrics. These distance metrics are typically experimental and are based on many paired comparisons and probit analysis. The predominant focus is on the derivation of a uniform metric that is optimized for small color differences around the just-noticeable difference limit. Increasingly sophisticated mathematical modeling is then used to fit a range of laboratory data sets. While this work has yielded invaluable industrial applications, it has perhaps left certain aspects of color differences under explored. For example how do non-experts typically describe color differences? What are the natural language characteristics of the description of color difference? This paper considers color differences specifically from the nominal or linguistic perspective.

  18. Advance directives in english and French law: different concepts, different values, different societies. (United States)

    Horn, Ruth Judith


    In Western societies advance directives are widely recognised as important means to extend patient self-determination under circumstances of incapacity. Following other countries, England and France have adopted legislation aiming to clarify the legal status of advance directives. In this paper, I will explore similarities and differences in both sets of legislation, the arguments employed in the respective debates and the socio-political structures on which these differences are based. The comparison highlights how different legislations express different concepts emphasising different values accorded to the duty to respect autonomy and to protect life, and how these differences are informed by different socio-political contexts. Furthermore each country associates different ethical concerns with ADs which raise doubts about whether these directives are a theoretical idea which is hardly applicable in practice.

  19. Negative campaigning across different communication channels: different ball games?

    NARCIS (Netherlands)

    Walter, A.S.; Vliegenthart, R.


    In this article, the authors address the question of to what extent negative political campaigning differs when looking at different communication channels. They compare paid publicity, election debates, and newspaper coverage for the 2006 Dutch parliamentary elections and conduct an elaborate

  20. The Effects of Crowding Stress, Different Diets and Different Size ...

    African Journals Online (AJOL)

    The Effects of Crowding Stress, Different Diets and Different Size Classes on the Growth Rate of Clarias gariepinus. ... showed that: at constant area, growth rate of Clarias gariepinus reduced by as much as 75% when the density was increased from one to three individuals per square metre - regardless of food supplied.

  1. Speakers of different languages process the visual world differently. (United States)

    Chabal, Sarah; Marian, Viorica


    Language and vision are highly interactive. Here we show that people activate language when they perceive the visual world, and that this language information impacts how speakers of different languages focus their attention. For example, when searching for an item (e.g., clock) in the same visual display, English and Spanish speakers look at different objects. Whereas English speakers searching for the clock also look at a cloud, Spanish speakers searching for the clock also look at a gift, because the Spanish names for gift (regalo) and clock (reloj) overlap phonologically. These different looking patterns emerge despite an absence of direct language input, showing that linguistic information is automatically activated by visual scene processing. We conclude that the varying linguistic information available to speakers of different languages affects visual perception, leading to differences in how the visual world is processed. (c) 2015 APA, all rights reserved).

  2. Sexual differences of human brain

    Directory of Open Access Journals (Sweden)

    Masoud Pezeshki Rad


    Full Text Available During the last decades there has been an increasing interest in studying the differences between males and females. These differences extend from behavioral to cognitive to micro- and macro- neuro-anatomical aspects of human biology. There have been many methods to evaluate these differences and explain their determinants. The most studied cause of this dimorphism is the prenatal sex hormones and their organizational effect on brain and behavior. However, there have been new and recent attentions to hormone's activational influences in puberty and also the effects of genomic imprinting. In this paper, we reviewed the sex differences of brain, the evidences for possible determinants of these differences and also the methods that have been used to discover them. We reviewed the most conspicuous findings with specific attention to macro-anatomical differences based on Magnetic Resonance Imaging (MRI data. We finally reviewed the findings and the many opportunities for future studies.

  3. Ethnic Differences in Bone Health

    Directory of Open Access Journals (Sweden)

    Ayse eZengin


    Full Text Available There are differences in bone health between ethnic groups in both men and in women. Variations in body size and composition are likely to contribute to reported differences. Most studies report ethnic differences in areal bone mineral density (aBMD which do not consistently parallel ethnic patterns in fracture rates. This suggests that other parameters beside aBMD should be considered when determining fracture risk between and within populations, including other aspects of bone strength: bone structure and microarchitecture as well muscle strength (mass, force generation, anatomy and fat mass. We review what is known about differences in bone-densitometry derived outcomes between ethnic groups and the extent to which they account for the differences in fracture risk. Studies are included that were published primarily between 1994 – 2014. A ‘one size fits all approach’ should not be used to understand better ethnic differences in fracture risk.

  4. Feynman integrals and difference equations

    Energy Technology Data Exchange (ETDEWEB)

    Moch, S. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); Schneider, C. [Johannes Kepler Univ., Linz (Austria). Research Inst. for Symbolic Computation


    We report on the calculation of multi-loop Feynman integrals for single-scale problems by means of difference equations in Mellin space. The solution to these difference equations in terms of harmonic sums can be constructed algorithmically over difference fields, the so-called {pi}{sigma}{sup *}-fields. We test the implementation of the Mathematica package Sigma on examples from recent higher order perturbative calculations in Quantum Chromodynamics. (orig.)

  5. Gender differences in social networks


    Komaromi, Bojana


    This paper examines gender differences in different types of social networks. One of the main concepts relevant for studying gender differences is homophily, which refers to the tendency of people to interact more with similar individuals. In this paper homophily is analysed within the structural perspective which explains that the structures of our networks depend primarily on opportunities for social interactions, i.e. the composition and dynamics of the social context in which these intera...

  6. Individual differences in behavioural plasticities. (United States)

    Stamps, Judy A


    Interest in individual differences in animal behavioural plasticities has surged in recent years, but research in this area has been hampered by semantic confusion as different investigators use the same terms (e.g. plasticity, flexibility, responsiveness) to refer to different phenomena. The first goal of this review is to suggest a framework for categorizing the many different types of behavioural plasticities, describe examples of each, and indicate why using reversibility as a criterion for categorizing behavioural plasticities is problematic. This framework is then used to address a number of timely questions about individual differences in behavioural plasticities. One set of questions concerns the experimental designs that can be used to study individual differences in various types of behavioural plasticities. Although within-individual designs are the default option for empirical studies of many types of behavioural plasticities, in some situations (e.g. when experience at an early age affects the behaviour expressed at subsequent ages), 'replicate individual' designs can provide useful insights into individual differences in behavioural plasticities. To date, researchers using within-individual and replicate individual designs have documented individual differences in all of the major categories of behavioural plasticities described herein. Another important question is whether and how different types of behavioural plasticities are related to one another. Currently there is empirical evidence that many behavioural plasticities [e.g. contextual plasticity, learning rates, IIV (intra-individual variability), endogenous plasticities, ontogenetic plasticities) can themselves vary as a function of experiences earlier in life, that is, many types of behavioural plasticity are themselves developmentally plastic. These findings support the assumption that differences among individuals in prior experiences may contribute to individual differences in behavioural

  7. Differences in explosive power between basketball players of different age

    Directory of Open Access Journals (Sweden)

    Aksović Nikola


    Full Text Available The aim of this research is to determine the differences in explosive power between basketball players of different age. This research was conducted on the sample of 34 basketball players, 17 of them were at the age of 11 and 17 of them were at the age of 14 (±0.5 years. They are all members of basketball club 'Ras', Novi Pazar. Six different kinds of test were used to estimate their explosive power: long jump, triple jump, medicine balls throw while lying, medicine ball sit‐up throw, sprinting in 20 m from the low start position, sprinting in 30 m from the high start position. For identifying the significant differences in main values of two groups of players was used t-test. The statistics significance in differences was analyzed at the level (p<0.05. The results show that there are statistically significant differences between basketball players of different age in all observed variables and that they go in favor of players aged 14.

  8. Metabolic Differences between Dogs of Different Body Sizes

    Directory of Open Access Journals (Sweden)

    Rondo P. Middleton


    Full Text Available Introduction. The domesticated dog, Canis lupus familiaris, has been selectively bred to produce extreme diversity in phenotype and genotype. Dogs have an immense diversity in weight and height. Specific differences in metabolism have not been characterized in small dogs as compared to larger dogs. Objectives. This study aims to identify metabolic, clinical, and microbiota differences between small and larger dogs. Methods. Gas chromatography/mass spectrometry, liquid chromatography/tandem mass spectrometry, clinical chemistry analysis, dual-energy X-ray absorptiometry, and 16S pyrosequencing were used to characterize blood metabolic, clinical, and fecal microbiome systems, respectively. Eighty-three canines from seven different breeds, fed the same kibble diet for 5 weeks, were used in the study. Results. 449 metabolites, 16 clinical parameters, and 6 bacteria (at the genus level were significantly different between small and larger dogs. Hierarchical clustering of the metabolites yielded 8 modules associated with small dog size. Conclusion. Small dogs had a lower antioxidant status and differences in circulating amino acids. Some of the amino acid differences could be attributed to differences in microflora. Additionally, analysis of small dog metabolites and clinical parameters reflected a network which strongly associates with kidney function.

  9. Different positions of uncertain lives

    DEFF Research Database (Denmark)

    Stenum, Helle

    On the basis of my ethnographic research in Denmark and Spain, I will investigate and compare four different positions of illegality in two different national contexts. Legal and institutional practices on the one hand produce the conditions for migrant illegality as such, but are also decisive...

  10. Individual Differences, Computers, and Instruction. (United States)

    Ayersman, David J.; Minden, Avril von


    Provides a conceptual foundation for the development of hypermedia as an instructional tool for addressing individual differences in learning styles. Highlights include a literature review; computers and instruction; individual differences, computers, and instruction; cognitive controls; cognitive styles and learning; personality types; and future…

  11. Gender Differences in Ethnic Entrepreneurship

    NARCIS (Netherlands)

    Baycan, T.; Masurel, E.; Nijkamp, P.


    Gender-based differences are the most important topic of discussion in female entrepreneurship studies. While earlier studies focused on psychological and sociological characteristics of female entrepreneurs, assuming there were only a few differences between males and females, more recent studies

  12. Computerized Assessment of Individual Differences (United States)


    abilities. In R. Kanfer, P. Ackerman, & R. Cudek (Eds.), Learning and individual differences : Abilities, motivation and methodology (pp. 175-202...information coordination abilities. Paper presented at the Minnesota Symposium on Learning and Individual Differences . Yee, P. L. & Hunt, E. (1988, November

  13. Sibling Differences in Divorced Families. (United States)

    Monahan, Susanne C.; And Others


    Sibling differences in family processes, such as parental monitoring, and in individual adjustment were examined for 133 pairs of 10- to 18-year-old siblings in divorced families. Found that siblings who lived apart after their parents' divorce differed more than siblings who lived together. (MDM)

  14. Gender Differences in Moral Motivation (United States)

    Nunner-Winkler, Gertrud; Meyer-Nikele, Marion; Wohlrab, Doris


    Moral gender differences have been discussed in terms of Kohlbergian stages and content of orientations and taken to correspond to universal stable male and female features. The present study instead focuses on moral motivation and explains differences in terms of role expectations. We assessed moral motivation in 203 adolescents by a newly…

  15. Computation of Difference Grobner Bases

    Directory of Open Access Journals (Sweden)

    Vladimir P. Gerdt


    Full Text Available This paper is an updated and extended version of our note \\cite{GR'06} (cf.\\ also \\cite{GR-ACAT}. To compute difference \\Gr bases of ideals generated by linear polynomials we adopt to difference polynomial rings the involutive algorithm based on Janet-like division. The algorithm has been implemented in Maple in the form of the package LDA (Linear Difference Algebra and we describe the main features of the package. Its applications are illustrated by generation of finite difference approximations to linear partial differential equations and by reduction of Feynman integrals. We also present the algorithm for an ideal generated by a finite set of nonlinear difference polynomials. If the algorithm terminates, then it constructs a \\Gr basis of the ideal.

  16. Regional differences in tropospheric ozone

    Energy Technology Data Exchange (ETDEWEB)

    Builtjes, P.; Esser, P. [TNO Inst. of Environmental Sciences, Energy Research and Process Innovation Apeldoorn (Netherlands)


    Analysis of ozone measurements over Europe, as well as model calculations indicate large differences in the relative importance of the phenomena controlling ozone over different areas in Europe. The ozone budget, consisting of chemistry, deposition and horizontal and vertical transport, shows differences due to differences in emission density and in dry deposition values, best exemplified by the land-sea effect. In this paper, some initial results will be presented of an analysis of regional differences, using the results of the 3-D Eulerian grid model LOTOS (Long Term Ozone Simulation) over 1994, based on the hourly O{sub 3} results of LOTOS on a grid scale of 1/2 deg. Latitude * 1 deg. Longitude. (au)

  17. Bayesian Models of Individual Differences. (United States)

    Powell, Georgie; Meredith, Zoe; McMillin, Rebecca; Freeman, Tom C A


    According to Bayesian models, perception and cognition depend on the optimal combination of noisy incoming evidence with prior knowledge of the world. Individual differences in perception should therefore be jointly determined by a person's sensitivity to incoming evidence and his or her prior expectations. It has been proposed that individuals with autism have flatter prior distributions than do nonautistic individuals, which suggests that prior variance is linked to the degree of autistic traits in the general population. We tested this idea by studying how perceived speed changes during pursuit eye movement and at low contrast. We found that individual differences in these two motion phenomena were predicted by differences in thresholds and autistic traits when combined in a quantitative Bayesian model. Our findings therefore support the flatter-prior hypothesis and suggest that individual differences in prior expectations are more systematic than previously thought. In order to be revealed, however, individual differences in sensitivity must also be taken into account.

  18. Response mode differences in perspective taking: differences in representation or differences in retrieval? (United States)

    Kelly, Jonathan W; McNamara, Timothy P


    Three experiments explored whether response mode differences in perspective taking result from different spatial representations or different retrieval processes. Participants learned object locations and then, while blindfolded, pointed to or verbally described object locations from perspectives aligned or misaligned with their facing direction and aligned or misaligned with the learning perspective. Pointing was facilitated from the perspective aligned with the body during testing. Similar facilitation occurred when verbally labeling, but only when conducted in the context of pointing (e.g., after pointing). Without this pointing context, or after third-person strategy instructions, the effect of body alignment was eliminated for verbal responses. Pointing was less responsive to context and strategy. Across all conditions, performance was facilitated for the learning perspective. Taken together, these experiments indicate that response mode differences are due to differences in the retrieval process, which varies with strategy, rather than differences in the organization of the underlying spatial memory.

  19. NMR structure of temporin-1 ta in lipopolysaccharide micelles: mechanistic insight into inactivation by outer membrane.

    Directory of Open Access Journals (Sweden)

    Rathi Saravanan

    Full Text Available BACKGROUND: Antimicrobial peptides (AMPs play important roles in the innate defense mechanism. The broad spectrum of activity of AMPs requires an efficient permeabilization of the bacterial outer and inner membranes. The outer leaflet of the outer membrane of Gram negative bacteria is made of a specialized lipid called lipopolysaccharide (LPS. The LPS layer is an efficient permeability barrier against anti-bacterial agents including AMPs. As a mode of protection, LPS can induce self associations of AMPs rendering them inactive. Temporins are a group of short-sized AMPs isolated from frog skin, and many of them are inactive against Gram negative bacteria as a result of their self-association in the LPS-outer membrane. PRINCIPAL FINDINGS: Using NMR spectroscopy, we have determined atomic resolution structure and characterized localization of temporin-1Ta or TA (FLPLIGRVLSGIL-amide in LPS micelles. In LPS micelles, TA adopts helical conformation for residues L4-I12, while residues F1-L3 are found to be in extended conformations. The aromatic sidechain of residue F1 is involved in extensive packing interactions with the sidechains of residues P3, L4 and I5. Interestingly, a number of long-range NOE contacts have been detected between the N-terminal residues F1, P3 with the C-terminal residues S10, I12, L13 of TA in LPS micelles. Saturation transfer difference (STD NMR studies demonstrate close proximity of residues including F1, L2, P3, R7, S10 and L13 with the LPS micelles. Notably, the LPS bound structure of TA shows differences with the structures of TA determined in DPC and SDS detergent micelles. SIGNIFICANCE: We propose that TA, in LPS lipids, forms helical oligomeric structures employing N- and C-termini residues. Such oligomeric structures may not be translocated across the outer membrane; resulting in the inactivation of the AMP. Importantly, the results of our studies will be useful for the development of antimicrobial agents with a

  20. Information retrieval and individual differences

    Directory of Open Access Journals (Sweden)

    Polona Vilar


    Full Text Available The paper presents individual differences, which are found in studies of information retrieval with emphasis on models of personality traits, cognitive and learning styles. It pays special attention to those models which are most often included in studies of information behaviour,information seeking,perceptions of IR systems, etc., but also brings forward some models which have not yet been included in such studies. Additionally, the relationship between different individual characteristics and individual’s chosen profession or academic area is discussed. In this context,the paper presents how investigation of individual differences can be useful in the design of IR systems.


    Directory of Open Access Journals (Sweden)

    Angelica-Nicoleta NECULĂESEI (ONEA


    Full Text Available Culture influences thinking, language and human behaviour. The social environment, in which individuals are born and live, shapes their attitudinal, emotional and behavioural reactions and the perceptions about what is happening around. The same applies in the case of assigned/assumed roles in society based on gender. Cultural dimensions that reflect differences in gender roles, but also elements related to the ethics of sexual difference were highlighted by many researchers. The presentation of these issues from the interdisciplinary perspective is the subject of this article. Briefly, the article refers to: importance of communication in transmission of roles of those two sexes, cultural dimensions that reflect role differences invarious cultures, discrimination issues and ethics of sexual difference.

  2. Animal Locomotion in Different Mediums

    Indian Academy of Sciences (India)

    IAS Admin

    GENERAL ARTICLE. RESONANCE. June 2016. Animal Locomotion in Different Mediums. The Adaptations of Wetland Organisms. Abdul Jamil Urfi. Keywords. Wetlands, animal locomotion, medium, terrestrial, aquatic, mudskipper. Abdul Jamil Urfi is. Associate Professor at. Department of Environ- mental Studies, University.

  3. Racial Differences in Youth Employment. (United States)

    Gardecki, Rosella M.


    Work experience at an early age has a positive impact on labor force attachment of different racial groups. However, racial gaps in employment that are present in the early teen years seem to continue into adulthood. (Author/SK)

  4. Gender differences and pain medication. (United States)

    Richardson, Jen; Holdcroft, Anita


    Subtle genetic and psychological variations are increasingly recognized to contribute to pain and analgesic efficacy and safety. The influence of sex on this relationship remains poorly understood, particularly in humans. The issue is complicated by the overlay of gender onto physical sex, and its associated stereotypes and expectations. Women appear to use more pain-relieving medications than men; however, it remains unclear whether these observations represent true differences in analgesic usage patterns, or reporting bias. Differences in analgesic efficacy relating to body composition, metabolism and hormonal profiles have been demonstrated. Psychological and social elements of gender have also been associated with altered pain experiences and analgesic use profiles, albeit with significant individual variations. Intra-group differences may ultimately prove more important than sex differences. Further research may unravel the various threads linking gender and sex effects on analgesia with the aim of individualizing analgesia to optimize pain relief.

  5. Sex differences in primary hypertension (United States)


    Men have higher blood pressure than women through much of life regardless of race and ethnicity. This is a robust and highly conserved sex difference that it is also observed across species including dogs, rats, mice and chickens and it is found in induced, genetic and transgenic animal models of hypertension. Not only do the differences between the ovarian and testicular hormonal milieu contribute to this sexual dimorphism in blood pressure, the sex chromosomes also play a role in and of themselves. This review primarily focuses on epidemiological studies of blood pressure in men and women and experimental models of hypertension in both sexes. Gaps in current knowledge regarding what underlie male-female differences in blood pressure control are discussed. Elucidating the mechanisms underlying sex differences in hypertension may lead to the development of anti-hypertensives tailored to one's sex and ultimately to improved therapeutic strategies for treating this disease and preventing its devastating consequences. PMID:22417477

  6. Gender differences in alcoholic cardiomyopathy. (United States)

    Fernández-Solà, Joaquim; Nicolás-Arfelis, Josep Maria


    The incidence, presentation, clinical features, and evolution of several cardiomyopathies have clear gender-related differences. In general, women show a different response to noxious cardiac agents than men, and they differ in myocardial adaptation to a variety of cardiac insults. Specifically in alcohol-induced heart disease, women have shown different alcohol metabolism features and distinct pathophysiologic mechanisms leading to a higher sensitivity to alcohol-induced heart damage. In preclinical alcohol-induced ventricular dysfunction, women were more sensitive to the toxic effects of ethanol than men. In overt alcoholic cardiomyopathy, women showed about the same prevalence of cardiomyopathy as men, despite having consumed far less ethanol. This supports a greater female propensity to alcohol-induced cardiac damage.

  7. Gender differences in gynecologist communication.

    NARCIS (Netherlands)

    Dulmen, A.M. van; Bensing, J.M.


    The intimate nature of gynecological health problems requires the physician's specific attention. On the basis of previous findings in primary care, female gynecologists are expected to communicate more affectively than men. This study addressed gender differences in gynecologist communication

  8. Advertising styles in different cultures

    Directory of Open Access Journals (Sweden)

    Krasulja Nevena


    Full Text Available Modern consumer is inhabitant of a "Global Village" as well as of its own national culture which largely influences his creation of a system of values, beliefs and style of life in general. According to adopted values and styles, consumers from different cultures have different buying behavior, different needs and preferences related to a product and they have their favorite advertising styles. As advertising reflects culture, symbols and rituals which are used are even more emphasized and strengthen cultural values, which are then used as a strong advertising style characteristic. Global advertisers are increasingly faced with different environment meaning. A fact that has been proved in practice is that standardized approach to advertising does not transmit values in a correct way, so the advertisers that want to achieve long term success must differentiate their brands to competitors'. In modern market environment strategy "Think globally, act locally" proved to be adequate for advertising in modern international market.

  9. Voice Collection under Different Spectrum


    Min Li; Yu-duo Wang


    According to the short-time Fourier transform theory and principle of digital filtering, this paper established a mathematical model called collection of voice signal collection at different spectrum. The voice signal was a non-stationary process, while the standard Fourier transform only applied to the periodic signal, transient signals or stationary random signal. Therefore, the standard Fourier transform could not be directly used for the speech signal. By controlling the input different t...

  10. Cultural differences in scene perception


    Alotaibi, Albandari


    Do individuals from different cultures perceive scenes differently? Does culture have an influence on visual attention processes? This thesis investigates not only what these influences are, and how they affect eye movements, but also examines some of the proposed mechanisms that underlie the cultural influence in scene perception. Experiments 1 & 2 showed that Saudi participants directed a higher number of fixations to the background of images, in comparison to the British participants. Brit...

  11. Normalizing difference in inclusive teaching. (United States)

    Baglieri, Susan; Knopf, Janice H


    Inclusion practices and special education can be transformed by using a disability studies perspective, which constructs differences as natural, acceptable, and ordinary. Although inclusion is a moral imperative in promoting social justice, some inclusive practices continue to marginalize students with disabilities. A truly inclusive school reflects a democratic philosophy whereby all students are valued, educators normalize difference through differentiated instruction, and the school culture reflects an ethic of caring and community.



    Angelica-Nicoleta NECULĂESEI (ONEA)


    Culture influences thinking, language and human behaviour. The social environment, in which individuals are born and live, shapes their attitudinal, emotional and behavioural reactions and the perceptions about what is happening around. The same applies in the case of assigned/assumed roles in society based on gender. Cultural dimensions that reflect differences in gender roles, but also elements related to the ethics of sexual difference were highlighted by many researchers. The presentation...

  13. Sex differences in semantic categorization


    Pasterski, Vickie; Zwierzynska, Karolina; Estes, Zachary


    Sex differences in certain cognitive abilities, including aspects of semantic processing, are well established. However, there have been no reports investigating a sex difference in semantic categorization. A total of 55 men and 58 women each judged 25 exemplars of natural categories (e.g., fruits) and 25 of artifact categories (e.g., tools) as a nonmember, partial member, or full member of the given category. Participants also rated confidence for each judgment. Women provided a greater numb...

  14. Same Game, Different Rules? Gender Differences in Political Participation. (United States)

    Coffé, Hilde; Bolzendahl, Catherine


    We investigate gender gaps in political participation with 2004 ISSP data for 18 advanced Western democracies (N: 20,359) using linear and logistic regression models. Controlling for socio-economic characteristics and political attitudes reveals that women are more likely than men to have voted and engaged in 'private' activism, while men are more likely to have engaged in direct contact, collective types of actions and be (more active) members of political parties. Our analysis indicates that demographic and attitudinal characteristics influence participation differently among men and among women, as well as across types of participation. These results highlight the need to move toward a view of women engaging in differing types of participation and based on different characteristics.


    Directory of Open Access Journals (Sweden)

    OTAVOVÁ, Miroslava


    Full Text Available The paper presents and discusses the results of statistical analysis of differences among scores obtained by students of different faculties of the University of Economics in Prague. The analysed dataset contains the scores for 2256 students that took basic mathematics course during the academic year 2013/2014. A two way analysis of variance was performed with semester and faculty as main factors. The interaction between these two factors was also considered. Students have to take two tests. At first, the sum of the scores obtained from both tests is analysed and then, the two tests are analysed separately. It turns out that the significance of factors is the same in the three analyses. The assumptions of linear models are verified. Due to problem of heteroscedasticity, weighted least squares are used and the possibility of using Box-Cox transformation is also discussed, as the errors are not normally distributed. Finally, the differences between the faculties are described.

  16. Genetic differences among ethnic groups. (United States)

    Huang, Tao; Shu, Yang; Cai, Yu-Dong


    Many differences between different ethnic groups have been observed, such as skin color, eye color, height, susceptibility to some diseases, and response to certain drugs. However, the genetic bases of such differences have been under-investigated. Since the HapMap project, large-scale genotype data from Caucasian, African and Asian population samples have been available. The project found that these populations were located in different areas of the PCA (Principal Component Analysis) plot. However, as an unsupervised method, PCA does not measure the differences in each single nucleotide polymorphism (SNP) among populations. We applied an advanced mutual information-based feature selection method to detect associations between SNP status and ethnic groups using the latest HapMap Phase 3 release version 3, which included more sub-populations. A total of 299 SNPs were identified, and they can accurately predicted the ethnicity of all HapMap populations. The 10-fold cross validation accuracy of the SMO (sequential minimal optimization) model on training dataset was 0.901, and the accuracy on independent test dataset was 0.895. In-depth functional analysis of these SNPs and their nearby genes revealed the genetic bases of skin and eye color differences among populations.

  17. [Growing old differently: Transdisciplinary perspective]. (United States)

    Zimmermann, H-P


    Growing old differently: the phrase is intended to call something other to mind than merely the fact that images and forms of old age and aging have multiplied and diversified to an enormous extent. The suggestion put forward here is that otherness (as opposed to mere differences) should be positively reinforced. In other words, it is not just a matter of noting different forms of old age and aging but more than this, of seeking out opportunities for aging differently. In order to explore this, the article follows an older strand of theory, which has recently come to be frequently quoted in gerontology: the phenomenology of difference as reasoned analytically by Lévinas and Sartre and applied to gerontology by Améry and de Beauvoir. Here, opportunities for aging crucially depend on the way we look at it, how we observe and describe it and not least, how gerontology frames it. A distinction is made between two perspectives and their associated consequences for old age: alienation and alterity. Alienation means looking at old age above all as a disconcerting "other", as a perplexing, problematic deviation from the norm of vitality. Alterity, by contrast, refers to different options for living life in old age: options to be explored and opened up in contradistinction to cultural or academic alienation. Not least, the article appeals for diversity in scholarly approaches and for cross-disciplinary perspectives.

  18. Physical fitness differences of students with different cardiorespiratory endurance levels

    Directory of Open Access Journals (Sweden)

    Stojanović Darko


    Full Text Available In order to determine physical fitness differences in students with different cardiorespiratory endurance levels, a study was conducted on a sample of students of the Faculty of Sport and Physical Education at the University of Nis. The sample was divided into two subsamples, where the first subsample comprised 27 female students and the other 35 male students. Physical fitness was assessed using eight tests from the Eurofit battery of tests: the single-leg balance test - for the assessment of general balance, plate tapping - for the assessment of speed of movement, sit-and-reach - for the assessment of flexibility, the standing broad jump - for the assessment of explosive strength, the handgrip test - for the assessment of static strength, sit-ups - for the assessment of repetitive trunk strength, the bent arm hang - for the assessment of muscular endurance and the 10x5 meter shuttle run - for the assessment of the speed/agility. Cardiorespiratory endurance was estimated with the aid of 20 m endurance shuttle-run test. Based on the level of cardiorespiratory endurance, the participants in each subsample, were divided into three groups using a cluster analysis: high (VKRI, average (PKRI and low level (NKRI. The physical fitness differences of students with different cardiorespiratory endurance levels were calculated using the one-way analysis of variance. The results showed that there were no differences in physical fitness of students with different cardiorespiratory endurance levels. Based on the results it can be concluded that the level of cardiorespiratory endurance does not affect the components of physical fitness among students of both sexes.

  19. Modeling Systematic Differences In Photometry by Different Observers (United States)

    Martin, John C.


    Photometric monitoring campaigns commonly increase their cadence and length of coverage by combining measurements from multiple observers (typically using different telescope/detector systems). However, systematic offsets between the calibration of different contributors can cause problems which may threaten to degrade the quality of an effort when analyzing the results. This is particularly common when the collaboration is put together post-hoc after the campaign but it can also be an unwelcome surprise for even the most carefully planned joint efforts. Here we will explore some of the issues and explore solutions which can be helpful for identifying and mitigating systematic offsets between observers during post-hoc analysis.

  20. the effect of difference photoperiod and different concentration of ...

    African Journals Online (AJOL)



    Nov 16, 2011 ... Full Length Research Paper. Effects of different photoperiods and concentrations of ... 2International Sturgeon Research Institute, P.O Box: 41635-3464, Rasht, Iran. Accepted 5 October, 2011. The freshwater ..... On the other hand, shorter day length decreased growth rates of cyanobacteria and diatoms,.

  1. Armed Conflict in Colombia : Different Resources Different Conflicts ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    This project will endeavor to shed light on how natural resources - specifically, coffee, oil, bananas, flowers, emeralds, coal and minerals (gold and nickel) - feed the various forms of armed conflict that occur in different parts of the country. Focusing on eight resources researchers will engage a variety of governmental and ...

  2. Different Strokes for Different Folks: Jung's Typology and Structured Experiences. (United States)

    Haber, Russell Alan


    Examined and compared the evaluations of students differentiated by Carl Jung's psychotypology when they were involved in either a session of nonverbal communication experiences or a session of fantasy experiences. Some of the Jungian psychological types preferred different structured experiences. (Author)

  3. "Really Really Different Different": Rurality, Regional Schools and Refugees (United States)

    Colvin, Neroli


    This article explores the dynamics of difference-making in a regional Australian town. Despite Australia's high levels of cultural diversity, many rural and regional areas remain predominantly "white" spaces, presided over by people of Anglo-Celtic ancestry but with small populations of indigenous Australians. Over the past decade,…

  4. Different Academics' Characteristics, Different Perceptions on Quality Assessment? (United States)

    Cardoso, Sonia; Rosa, Maria Joao; Santos, Cristina S.


    Purpose: The purpose of this paper is to explore Portuguese academics' perceptions on higher education quality assessment objectives and purposes, in general, and on the recently implemented system for higher education quality assessment and accreditation, in particular. It aims to discuss the differences of those perceptions dependent on some…

  5. Representations of women in music: what difference does difference ...

    African Journals Online (AJOL)

    Taking this position as a point of departure in a more general discussion of female resistance in recent forms of African popular music, difference is read as a source of power, which can function in musically nuanced ways as a form of public struggle against male domination – even though this may not always be obvious on ...

  6. Different biofilms, different disease? A clinical outcomes study. (United States)

    Foreman, Andrew; Wormald, Peter-John


    A potential role for biofilms in Chronic Rhinosinusitis (CRS) has been proposed, and the adverse impact they have on disease severity and postoperative outcomes has also been well described. Recent advances have allowed the species within the biofilms of CRS patients to be clearly characterized. This study investigates whether different biofilm species have different disease outcomes. Retrospective review. Twenty-four patients with medically recalcitrant CRS undergoing Endoscopic Sinus Surgery (ESS), in whom we had previously characterized their biofilms using fluorescence in situ hybridization (FISH), were reviewed a median of 11 months after their surgery. They were evaluated for preoperative disease markers and evidence of on-going disease in the postoperative period. Thirty-seven biofilms were identified in the 24 patients. Almost half had polymicrobial biofilms. The presence of polymicrobial, rather than single-species biofilms adversely affected preoperative disease severity but did not alter postsurgical outcome. Patients with single organism Haemophilus influenzae biofilms presented with mild disease symptomatically and radiologically and achieved normal mucosa a short time after their surgery. Conversely, patients with Staphlococcus aureus in their biofilm makeup had more severe disease and a more complicated postoperative course. The effect of Pseudomonas aeruginosa and fungal biofilms is less clear. Different biofilm species are associated with different disease phenotypes. H. influenzae biofilms are typically found in patients with mild disease, whereas S. aureus is associated with a more severe, surgically recalcitrant pattern.


    Directory of Open Access Journals (Sweden)

    Miroslav Smajić


    Full Text Available Introduction: Tennis is polistructural activity acyclic type of movement. A large number of movement structures and situations in a tennis game (technical and tactical variants indicates that the success of players determined by the level and structure of a large number of motor abilities, knowledge and qualities, of which some can be measured and analyzed. The measurement of these abilities and traits allows better planning, programming and control of the training process and to improve the sports form. The aim of the research was directed to determining the differences in motor abilities, of different sexes. Methods: The sample of 51 subjects aged 7 years (± 6 months, of which 23 boys and 28 girls tennis school participants TC "Palic" from Palic, carried out the measurement of motor abilities. The sample tests consisted of 12 tests: backward polygon, polygon with skipping and swiping, bat quickness, shooting horizontal objectives handed, shooting in the frame, target stick, keeping the ball with his hand, refusing racquet balls, fans, precision small vertical specific objectives, specific precision large vertical target, the specific objectives of the horizontal accuracy. Differences in motor abilities tennis players of different sexes was determined by using multivariate analysis of variance (MANOVA. Results: On the basis of the research it can be concluded that there are no statistically significant differences between boys and girls in terms of treated motor abilities. Discussion: Tennis is characterized by a very large number of different techniques strokes and movements, which are mostly performed at maximum speed for a long time, and it is logical that the success in tennis affects a larger number of motor skills (Zmajić, 2003. Development of speed, agility and explosiveness is very important for success in a tennis game, because tennis game consists of a number of different explosive reaction to a variety of changes in the situation

  8. Gender differences: are there differences even in Pediatrics and Neonatology?

    Directory of Open Access Journals (Sweden)

    Francesco Tandoi


    Full Text Available The approach to research on gender differences in an evolutionary context has always been complex. Many factors, from those initially linked to preliminary considerations about the differences between the sexes in different historical and cultural moments have often influenced studies of this type. Gender Medicine, consolidated in the United States as a research field since the 1980s, studies the way in which membership in gender, male or female, affects the development and impact of disease and response to therapy. We can say that this is a new, transverse dimension of Medicine that assesses gender differences in physiology and pathophysiology of many clinical diseases, with the aim of reaching treatment decisions based on evidence in both men and women. In an historical moment focused on the individualization/personalization of care, among the objectives that modern health care has been given, there is this research aimed at identifying as early as possible gender-related diseases with the aim of identifying causes and possible methods of intervention. It leads to defining a kind of Medicine, a recent branch of biomedical science, that focuses on recognizing and analyzing the differences arising from the belonging to a gender, male or female, from several aspects: organic, functional, psychological, pharmacological, social and cultural. A gender approach to Medicine can reduce the level of error in medical practice, promote therapeutic appropriateness, improve and customize therapies and generate savings for healthcare systems. These effects have been demonstrated for adults and need to be confirmed during infancy and childhood. The purpose of this discipline is to innovate and guarantee everyone, man or woman, newborn and children, the best possible treatment based on scientific evidence.

  9. Individual differences, cultural differences, and dialectic conflict description and resolution. (United States)

    Kim, Kyungil; Markman, Arthur B


    Previous research suggests that members of East Asian cultures show a greater preference for dialectical thinking than do Westerners. This paper attempts to account for these differences in cognition using individual difference variables that may explain variation in performance both within and across cultures. Especially, we propose that the abovementioned cultural differences are rooted in a greater fear of isolation (FOI) in East Asians than in Westerners. To support this hypothesis, in Experiment 1, we manipulated FOI in American participants before having them resolve two conflicts: an interpersonal conflict and a conflict between an individual and an institution. We found that the Americans among whom a high level of FOI had been induced were more likely to look for a dialectical resolution than those among whom a low level had been prompted. The relationship between conflict resolution and FOI was further investigated in Experiment 2, in which FOI was not manipulated. The results indicated that Koreans had higher chronic FOI on average than did the Americans. Compared to the Americans, the Koreans were more likely to resolve the interpersonal conflict dialectically, but did not show the same bias in resolving the person-institution conflict. The differences in the preference for dialectical resolution between FOI conditions in Experiment 1 and cultural groups in Experiment 2 were mediated by FOI. These findings bolster previous research on FOI in showing that chronic levels of FOI are positively related to both preference for dialectical sentences and sensitivity to context. They provide clearer insight into how differences in FOI affect attention and thereby higher-level reasoning such as dialectic description and conflict resolution.

  10. Differences in morphological characteristics tennis players of different sex

    Directory of Open Access Journals (Sweden)

    Barašić Huba Aleksandar


    Full Text Available According to the nature of scientific research, this study belongs to the category of empirical, while according to the purpose of undertaking represents applied, that, applied research that aims to acquire new knowledge and information necessary for practical application in the field of tennis, and more broadly in the practice of teaching in educational institutions (Bala, 2007. In terms of temporal specificity research is transversal character, and consists of a one-time measurement of appropriate morphological characteristics of young tennis players. In relation to the degree of control, this scientific research belongs to the category of field research that was conducted in natural living conditions (Bala, 2007. The aim of this research was directed toward determining the differences in morphological characteristics depending on the sex. The sample consisted of 51 subjects aged 7 years (± 6 months, of which 23 boys and 28 girls enrolled in school tennis TK 'Palic 1878' from Palic. For the evaluation of morphological characteristics applied 9 anthropometric measures that defined longitudinal and transversal dimensionality of the skeleton and the volume and mass of the body, measured according to the International Biological Program. Differences in morphological characteristics of players of different sexes were determined by using multivariate analysis of variance and univariate analysis of variance. On the basis of the research it can be concluded that there is a statistically significant difference between subjects of different sexes in terms of their morphological characteristics. Changes in morphological characteristics can be attributed to the influence of the growth and development of the organism. The research results indicate faster growth of long tubular bones in boys. In recent years there has been the acceleration of these characteristics in comparison to the earlier generation of children, because they are boys and less girls

  11. Gender Differences in Impression Formation

    Directory of Open Access Journals (Sweden)

    Bogdana Humă


    Full Text Available This paper aims to highlight the differences between men and women regarding impressionformation. It is based on secondary analysis of the data gathered in two previous experiments withsimilar conditions. However, the hypotheses formulated within this study have not been testedbefore. The current analysis was conducted on 86 participants, 47 males and 39 females. Their agesranged between 15 and 32, as they were either high school or university students engaged in amaster’s program. Their task consisted of watching a 14 seconds long video of a female confederatereading a neutral text and then evaluating her using a semantic differential with four dimensions:sociability, ethics, power and activity. Based on previous studies, it was hypothesized that men andwomen will form different first impressions of the actor employed in the movie. More precisely, themajority of the studies undertaken in this area compare men and women’s accuracy scores of facialexpressions decoding, yielding mostly significant differences, with women achieving higheraccuracy. A small percentage has addressed other aspects of social perception like: personality traitsor socio-demographic characteristics, yielding similar results. However, the current experimentfailed to reveal any differences between men’s and women’s evaluations. Accuracy assessmentswere disregarded in this study, since establishing unequivocal criteria for personality traitsevaluation is yet to be achieved. The results are consistent with a small percentage of the studiesconducted on gender differences in social perception and allow multiple interpretations.

  12. Gender differences in economic experiments

    Directory of Open Access Journals (Sweden)

    Jürgen Ergun, Selim


    Full Text Available This paper reviews the experimental economics literature on gender differences concerning four salient subjects: risk aversion, trust, deception and leadership. We review both experiments conducted in a laboratory and field experiments. We summarize very briefly the main characteristics of the experiments we review and point out the main results related to gender differences. The vast majority of the articles we have revised document gender differences in behavior; differences which could be explained by sex-role stereotypes which could be formed even in early stages of life and/or hormonal differences such as the female hormone oxytocin or estrogen.

    Este artículo revisa la literatura en el área de economía experimental sobre las diferencias de género en cuatro temas destacados: aversión al riesgo, confianza, engaño y liderazgo. Se revisan tanto experimentos realizados en laboratorios como experimentos de campo. Resumimos brevemente las principales características de los experimentos que consideramos y señalamos los principales resultados relacionados con las diferencias de género. La gran mayoría de los artículos que hemos revisado documentan diferencias de género en el comportamiento. Estas diferencias podrían explicarse por los estereotipos de roles sexuales que podrían formarse incluso en edades tempranas y / o diferencias hormonales como la hormona femenina oxitocina, o el estrógeno.

  13. Gender differences in social networks

    Directory of Open Access Journals (Sweden)

    Komaromi Bojana


    Full Text Available This paper examines gender differences in different types of social networks. One of the main concepts relevant for studying gender differences is homophily, which refers to the tendency of people to interact more with similar individuals. In this paper homophily is analysed within the structural perspective which explains that the structures of our networks depend primarily on opportunities for social interactions, i.e. the composition and dynamics of the social context in which these interactions are embedded. Homophily is evident among males and females as early as in childhood, only to be even more prominent in school and adult years. Sex segregation is probably the most evident in the organisational context, where it has detrimental effects on women's careers, as women are generally underrepresented in positions of power and authority. Research in the last two decades pointed to the facts: 1 that men and women have very different types of organisational networks, 2 that successful men and women adopt different strategies to reach similar career objectives and acquire similar resources, and 3 that organisations also need to be actively involved in solving these gender-related issues.

  14. Coping with congenital hand differences. (United States)

    Franzblau, Lauren E; Chung, Kevin C; Carlozzi, Noelle; Chin, Autumn Y T; Nellans, Kate W; Waljee, Jennifer F


    Although functional outcomes following reconstruction for congenital hand differences are frequently described, much less is known regarding children's ability to cope with the psychosocial effects of these conditions. The authors qualitatively explored stress and coping mechanisms among children following reconstructive surgery for congenital hand differences. Forty patients and their parents participated in semistructured interviews examining children's stress related to hand functioning and appearance, emotional responses to stress, and coping strategies. Interviews were audio-taped, transcribed, and analyzed thematically. A consensus taxonomy for classifying content evolved from comparisons of coding by two reviewers. Themes expressed by participants were studied for patterns of connection and grouped into broader categories. In this sample, 58 percent of children and 40 percent of parents reported stress related to congenital hand differences, attributed to functional deficits (61 percent), hand appearance (27 percent), social interactions (58 percent), and emotional reactions (46 percent). Among the 18 children who reported stress, 43 percent of parents were not aware of the presence of stress. Eight coping strategies emerged, including humor (12 percent), self-acceptance (21 percent), avoidance (27 percent), seeking external support (30 percent), concealment (30 percent), educating others (9 percent), support programs (21 percent), and religion (24 percent). Although children with congenital hand differences often experience emotional stress related to functional limitations and aesthetic deformities, many apply positive coping mechanisms that enhance self-esteem. Clinicians caring for children with congenital hand differences should inform families about potential sources of stress to direct resources toward strengthening coping strategies and support systems.

  15. Sex differences in semantic categorization. (United States)

    Pasterski, Vickie; Zwierzynska, Karolina; Estes, Zachary


    Sex differences in certain cognitive abilities, including aspects of semantic processing, are well established. However, there have been no reports investigating a sex difference in semantic categorization. A total of 55 men and 58 women each judged 25 exemplars of natural categories (e.g., FRUITS) and 25 of artifact categories (e.g., TOOLS) as a nonmember, partial member, or full member of the given category. Participants also rated confidence for each judgment. Women provided a greater number of vague (partial member) judgments whereas men provided more inclusive (full member) judgments of artifacts but more exclusive (nonmember) judgments of natural categories. The sex difference in vagueness was observed across domains (Cohen's d = .56). Confidence predicted categorization among both men and women, such that more confident participants exhibited fewer vague category judgments. However, men and women were equally confident in their category judgments, and confidence failed to explain the sex difference in categorization. Men and women appear to categorize the same common objects in systematically different ways.

  16. Systematic Differences and Random Rates

    DEFF Research Database (Denmark)

    Knudsen, Thorbjørn; Levinthal, Daniel A.; Winter, Sidney G.


    A fundamental premise of the strategy field is the existence of persistent firm level differences in resources and capabilities. This property of heterogeneity should express itself in a variety of empirical “signatures,” such as firm performance and arguably systematic and persistent differences......, across a population of firms and over time, firmgrowth at any point is, on average, proportionate to size of the firm.We develop a theoretical argument that provides a reconciliation of this apparent paradox. The model implies that in early stages of an industry history. firm growth may have a systematic...... evolutionary dynamics of firm entry, and the subsequent consolidation of market share and industry shake-out is considered, then during early epochs of industry evolution, one would tend to observe systematic differences in growth rates associated with firm’s competitive fitness. Thus, it is only...

  17. Language Differences and Operation Mode

    DEFF Research Database (Denmark)

    Dasi, Angels; Pedersen, Torben


    Language serves different purposes depending on the international activity in question. Language has many dimensions and firms’ communicative requirements vary by operational platform. We argue that different dimensions of language vary in their importance depending on the operation mode chosen...... for a foreign market, so that language distance matters in the case of a home-based sales force, while language incidence is key when operating through a local agent. The hypotheses are tested on a large data set encompassing 462 multinational corporations headquartered in Finland, South Korea, New Zealand......, and Sweden that have undertaken a business operation in a foreign country....

  18. Sex differences in glucose levels

    DEFF Research Database (Denmark)

    Faerch, K; Borch-Johnsen, Knut; Vaag, A


    We aimed to examine whether sex differences in fasting plasma glucose (FPG), 2 h post-OGTT plasma glucose (2hPG) and HbA(1c) could be explained by differences in body size and/or body composition between men and women in a general non-diabetic Danish population. Moreover, we aimed to study to what...... degree the newly suggested high-risk HbA(1c) criteria overlapped with the current OGTT-based criteria of glucose intolerance....

  19. Whiteness and difference in nursing. (United States)

    Allen, David G


    This paper uses a semiotic, performative theory of language and post-colonial theory to argue that nursing's representations of 'multiculturalism' need to be grounded in a theory of whiteness, an historicized understanding of how ethnic/cultural differences come to be represented in the ways they are and informed by Foucault's notions of power/knowledge. Using nursing education and 'cultural compentency' as examples, the paper draws on a range of literatures to suggest more critical and politically productive ways of approaching difference from within nursing's largely white interpretive framework.

  20. Color difference thresholds in dentistry. (United States)

    Paravina, Rade D; Ghinea, Razvan; Herrera, Luis J; Bona, Alvaro D; Igiel, Christopher; Linninger, Mercedes; Sakai, Maiko; Takahashi, Hidekazu; Tashkandi, Esam; Perez, Maria del Mar


    The aim of this prospective multicenter study was to determine 50:50% perceptibility threshold (PT) and 50:50% acceptability threshold (AT) of dental ceramic under simulated clinical settings. The spectral radiance of 63 monochromatic ceramic specimens was determined using a non-contact spectroradiometer. A total of 60 specimen pairs, divided into 3 sets of 20 specimen pairs (medium to light shades, medium to dark shades, and dark shades), were selected for psychophysical experiment. The coordinating center and seven research sites obtained the Institutional Review Board (IRB) approvals prior the beginning of the experiment. Each research site had 25 observers, divided into five groups of five observers: dentists-D, dental students-S, dental auxiliaries-A, dental technicians-T, and lay persons-L. There were 35 observers per group (five observers per group at each site ×7 sites), for a total of 175 observers. Visual color comparisons were performed using a viewing booth. Takagi-Sugeno-Kang (TSK) fuzzy approximation was used for fitting the data points. The 50:50% PT and 50:50% AT were determined in CIELAB and CIEDE2000. The t-test was used to evaluate the statistical significance in thresholds differences. The CIELAB 50:50% PT was ΔEab  = 1.2, whereas 50:50% AT was ΔEab  = 2.7. Corresponding CIEDE2000 (ΔE00 ) values were 0.8 and 1.8, respectively. 50:50% PT by the observer group revealed differences among groups D, A, T, and L as compared with 50:50% PT for all observers. The 50:50% AT for all observers was statistically different than 50:50% AT in groups T and L. A 50:50% perceptibility and ATs were significantly different. The same is true for differences between two color difference formulas ΔE00 /ΔEab . Observer groups and sites showed high level of statistical difference in all thresholds. Visual color difference thresholds can serve as a quality control tool to guide the selection of esthetic dental materials, evaluate clinical performance, and

  1. Asthma is Different in Women (United States)

    Erzurum, Serpil C.


    Gender differences in asthma incidence, prevalence and severity have been reported worldwide. After puberty, asthma becomes more prevalent and severe in women, and is highest in women with early menarche or with multiple gestations, suggesting a role for sex hormones in asthma genesis. However, the impact of sex hormones on the pathophysiology of asthma is confounded by and difficult to differentiate from age, obesity, atopy, and other gender associated environmental exposures. There are also gender discrepancies in the perception of asthma symptoms. Understanding gender differences in asthma is important to provide effective education and personalized management plans for asthmatics across the lifecourse. PMID:26141573

  2. Travel Behaviour of Different Ages


    Kuusela, Kukka-Maaria


    The objective of this thesis was to examine tourism behaviour in different age groups. I chose two different age groups who are and continue to be a very important customer segment in the tourism sector. Seniors are a growing age group in Finland and they are increasingly using tourism services. As a result, companies have begun to invest in them, which means positive growth in this sector. The other examined age group is youngsters/young adults which is a continuously growing customer segmen...

  3. On a fractional difference operator

    Directory of Open Access Journals (Sweden)

    P. Baliarsingh


    Full Text Available In the present article, a set of new difference sequence spaces of fractional order has been introduced and subsequently, an application of these spaces, the notion of the derivatives and the integrals of a function to the case of non-integer order have been generalized. Certain results involving the unusual and non-uniform behavior of the corresponding difference operator have been investigated and also been verified by using some counter examples. We also verify these unusual and non-uniform behaviors by studying the geometry of fractional calculus.

  4. Speech versus nonspeech: different tasks, different neural organization. (United States)

    Bunton, Kate


    This article reviews the extant studies of the relation of oromotor nonspeech activities to speech production. The relevancy of nonspeech oral motor behaviors to speech motor performance in assessment and treatment is challenged on several grounds. First, contemporary motor theory suggests that movement control is task specific. In other words, it is tied to the unique goals, sources of information, and characteristics of varying motor acts. Documented differences in movement characteristics for speech production versus nonspeech oral motor tasks support this claim. Second, advantages of training nonspeech oral motor tasks versus training speech production are not supported by current principles of motor learning and neural plasticity. Empirical data supports experience-specific training. Finally, functional imaging studies document differences in activation patterns for speech compared with nonspeech oral motor tasks in neurologically healthy individuals.

  5. Paintings discrimination by mice: Different strategies for different paintings. (United States)

    Watanabe, Shigeru


    C57BL/6 mice were trained on simultaneous discrimination of paintings with multiple exemplars, using an operant chamber with a touch screen. The number of exemplars was successively increased up to six. Those mice trained in Kandinsky/Mondrian discrimination showed improved learning and generalization, whereas those trained in Picasso/Renoir discrimination showed no improvements in learning or generalization. These results suggest category-like discrimination in the Kandinsky/Mondrian task, but item-to-item discrimination in the Picasso/Renoir task. Mice maintained their discriminative behavior in a pixelization test with various paintings; however, mice in the Picasso/Renoir task showed poor performance in a test that employed scrambling processing. These results do not indicate that discrimination strategy for any Kandinsky/Mondrian combinations differed from that for any Picasso/Monet combinations but suggest the mice employed different strategies of discrimination tasks depending upon stimuli. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Speech versus Nonspeech: Different Tasks, Different Neural Organization (United States)

    Bunton, Kate


    This article reviews the extant studies of the relation of oromotor nonspeech activities to speech production. The relevancy of nonspeech oral motor behaviors to speech motor performance in assessment and treatment is challenged on several grounds. First, contemporary motor theory suggests that movement control is task-specific; in other words, tied to the unique goals, sources of information and characteristics of varying motor acts. Documented differences in movement characteristics for speech production versus nonspeech oral motor tasks support this claim. Second, advantages of training nonspeech oral motor tasks versus training speech production are not supported by current principles of motor learning and neural plasticity. Empirical data supports experience-specific training. Finally, functional imaging studies document differences in activation patterns for speech compared to nonspeech oral motor tasks in neurologically healthy individuals. PMID:19058113

  7. The Determinants of Overeducation: Different Measures, Different Outcomes?


    Verhaest, D.; Omey, E


    Purpose of the paper - To assess the sensitivity of the estimated determinants of overeducation to the used overeducation measure. Design/Methodology/Approach - We analyse the determinants of overeducation among Flemish school leavers in their first job by means of probit regression analysis. Overeducation is measured on the basis of job analysis, self-assessments and realised matches. Findings - Our results demonstrate that the application of different overeducation measures sometimes leads ...

  8. Communicating to the general public: different audiences, different needs. (United States)


    Culturally appropriate communication can develop favorable attitudes toward family planning and facilitate its rapid diffusion in a society. To achieve this objective, family planning administrators must attend to 3 interrelated aspects of the communication process: 1) the type of information that is to be communicated, 2) forms of communication that convey this information with different effects, and 3) the intended audience. Mass media such as radio, television, films, newspapers, magazines, and posters are effective in breaking down the taboos against discussion of family planning and sexual activity. They reach large numbers of people quickly and can inform people about how to locate resources. However, forms of communication that are immediate and familiar, such as interpersonal communication, are more effective than the mass media at influencing people to accept and practice family planning. To reach large numbers of people with the familiarity and persuasiveness of personal communication, many family planning programs identify subaudiences (for example, young people, breastfeeding mothers, women who want no more children) within their larger national audience. By tailoring messages to specific groups, they can directly address the particular needs and characteristics of different audiences. Family planners also need to consider regional, ethnic, and socioeconomic differences that distinguish certain groups. For example, rural audiences are often unreceptive to impersonal mass media, but messages delivered through traditional communication or entertainment can be quite effective. Limited resources make communication all the more important, so that the impact of a message is maximized.

  9. Intercultural Education. Does working with different or differences?

    Directory of Open Access Journals (Sweden)

    Juan Bello Domínguez


    Full Text Available In the context of the Educative Politic formulated in the international scope by the Multilateral Organisms (Jomtiem, 1990; Salamanca, 1994; Dakar, 2000, it´s been emphasized the moral and political obligation of attend also the social groups that express and manifest social, cultural, economic, politic, and physical different characteristics, that a democratic society requires. The sociocultural and educative necessities of the groups raised in thisforums, were postulated from the dialog between the inclusion and theinterculturality , for guarantee the access to all the educative services available to society, “assuring” the resources for socialize, grow without losing their identity and been incorporated to socioeconomic processes. The persistent social, cultural, economic, and educative gaps, showed the number of people that lives in poverty and, the unequal distribution of the wealth; those gaps has been transformed in serious deficiencies, moreover of delay the democratization of the societies processes. However more tan been a relative marginal issue to the integration of the students in the regular educative system, the debate focuses in how to transform the educative systems and the knowledge environments for giving an answer to the differences of the students and not to the attention of the different.


    Directory of Open Access Journals (Sweden)

    V Babić


    Full Text Available The aim of the study was to determine the differences among subjects of different sprinting quality in the variables of running dynamics in the 100 m sprint event and in the variables of kinematic indicators (stride frequency, stride length, foot-ground contact duration, airborne phase duration. The research was conducted on a sample of 133 physical education teacher male students, aged 19 to 24 years (age 21.7 ± 1.08 yrs; body height 180.8 ± 6.98 cm; body mass 76.6 ± 7.62 kg, first year students at the Faculty of Kinesiology, University of Zagreb, who regularly attended their athletics classes. Basic descriptive statistical parameters were computed. Cluster analysis was used to determine sprinting-quality-based homogeneous groups of subjects. The qualitative differences among the subjects pertaining to the defined groups were established by canonical discriminant analysis. One significant discriminant function was obtained differentiating the group of students who performed well from all the other groups of students with poorer sprint performance. The best performance group demonstrated running technique characterised by the shortest foot-ground contact time in the phases of starting acceleration and maximum speed running, and a larger stride length in the phase of maximum speed running.

  11. Differences in masticatory function of subjects with different closing path. (United States)

    Kobayashi, Yoshinori; Shiga, Hiroshi; Yokoyama, Masaoki; Arakawa, Ichiro; Nakajima, Kunihisa


    The purpose of this study was to clarify whether there was a difference in the masticatory function between two masticatory path patterns: a convex closing path and a concave closing path. For 80 healthy subjects, the masticatory function (masticatory muscular activity, mandibular movement, and masticatory performance) when chewing a gummy jelly was recorded. Out of the 160 chewing cases (80 subjects chewing on either side), 65 cases (Group I) in which the incisal point opened in a linear or concave manner toward the working side and closed in a convex manner, and 15 cases (Group II) in which the opening path was the same as that in Group I, but the closing followed a concave path, were selected. For the masticatory function, the integral values per unit time of masseter and temporal muscular activities, the gape and masticatory width, the indicators representing the stability of movement path, and the glucose extraction from chewing gummy jelly were measured and compared between the two groups. The integral values of muscular activities and the amount of glucose extraction were significantly greater in Group I. The gape and masticatory width were not significantly different between the groups. The values of the indicators representing the stability of path were smaller in Group I than in Group II. From these results, it was suggested that there was a functional difference between Group I (with a convex closing path) and Group II (with a concave closing path), and that Group I had a superior masticatory function to Group II.

  12. Complementarity of different analysis methods

    NARCIS (Netherlands)

    Storm van Leeuwen, W.

    The spread of alpha waves over the scalp in normal subjects has been investigated with three forms of analysis: 1. continuous frequency analysis; 2. auto- and cross-correlation analysis; 3. topographic analysis. The data obtained with these analyses indicate that different alpha rhythms may be

  13. Gender Differences in Cognitive Development (United States)

    Ardila, Alfredo; Rosselli, Monica; Matute, Esmeralda; Inozemtseva, Olga


    The potential effect of gender on intellectual abilities remains controversial. The purpose of this research was to analyze gender differences in cognitive test performance among children from continuous age groups. For this purpose, the normative data from 7 domains of the newly developed neuropsychological test battery, the Evaluacion…

  14. Are specific emotions narrated differently? (United States)

    Habermas, Tilmann; Meier, Michaela; Mukhtar, Barbara


    Two studies test the assertion that anger, sadness, fear, pride, and happiness are typically narrated in different ways. Everyday events eliciting these 5 emotions were narrated by young women (Study 1) and 5- and 8-year-old girls (Study 2). Negative narratives were expected to engender more effort to process the event, be longer, more grammatically complex, more often have a complication section, and use more specific emotion labels than global evaluations. Narratives of Hogan's (2003) juncture emotions anger and fear were expected to focus more on action and to contain more core narrative sections of orientation, complication, and resolution than narratives of the outcome emotions sadness and happiness. Hypotheses were confirmed for adults except for syntactic complexity, whereas children showed only some of these differences. Hogan's theory that juncture emotions are restricted to the complication section was not confirmed. Finally, in adults, indirect speech was more frequent in anger narratives and internal monologue in fear narratives. It is concluded that different emotions should be studied in how they are narrated, and that narratives should be analyzed according to qualitatively different emotions.

  15. Sex differences in heart failure

    NARCIS (Netherlands)

    Meyer, Sven


    This thesis examined differences between men and women with heart failure. First, it was shown that biological sex is a strong modulator in the clinical expression of various cardiomyopathies. In the general population it was shown that men are more likely to develop heart failure with reduced

  16. A Different Angle on Perspective (United States)

    Frantz, Marc


    When a plane figure is photographed from different viewpoints, lengths and angles appear distorted. Hence it is often assumed that lengths, angles, protractors, and compasses have no place in projective geometry. Here we describe a sense in which certain angles are preserved by projective transformations. These angles can be constructed with…

  17. Individual Learner Differences in SLA (United States)

    Arabski, Janusz; Wojtaszek, Adam


    "Individual Learner Differences in SLA" addresses the apparently insoluble conflict between the unquestionably individual character of the process of second language acquisition/foreign language learning and the institutionalised, often inflexible character of formal instruction in which it takes place. How, then, is success in SLA so prevalent?

  18. Understanding Algorithms in Different Presentations (United States)

    Csernoch, Mária; Biró, Piroska; Abari, Kálmán; Máth, János


    Within the framework of the Testing Algorithmic and Application Skills project we tested first year students of Informatics at the beginning of their tertiary education. We were focusing on the students' level of understanding in different programming environments. In the present paper we provide the results from the University of Debrecen, the…

  19. Age Differences in Mystical Experience. (United States)

    Levin, Jeffrey S.


    Examined age differences in mystical experiences. According to 1988 General Social Survey (n=1,481) mystical experiences were somewhat more common in 1988 than in 1973, and deja vu, clairvoyance, and composite mysticism scores had increased with successively younger age cohorts. Private and subjective religiosity were positively related to overall…

  20. Gender differences in risk assessment

    Directory of Open Access Journals (Sweden)

    Christine R. Harris


    Full Text Available Across many real-world domains, men engage in more risky behaviors than do women. To examine some of the beliefs and preferences that underlie this difference, 657 participants assessed their likelihood of engaging in various risky activities relating to four different domains (gambling, health, recreation, and social, and reported their perceptions of (1 probability of negative outcomes, (2 severity of potential negative outcomes, and (3 enjoyment expected from the risky activities. Women's greater perceived likelihood of negative outcomes and lesser expectation of enjoyment partially mediated their lower propensity toward risky choices in gambling, recreation, and health domains. Perceptions of severity of potential outcomes was a partial mediator in the gambling and health domains. The genders did not differ in their propensity towards taking social risks. A fifth domain of activities associated with high potential payoffs and fixed minor costs was also assessed. In contrast to other domains, women reported being more likely to engage in behaviors in this domain. This gender difference was partially mediated by women's more optimistic judgments of the probability of good outcomes and of

  1. Joint Attention and Anthropological Difference

    Czech Academy of Sciences Publication Activity Database

    Urban, Petr


    Roč. 11, č. 1 (2014), s. 59-70 ISSN 1718-0198 R&D Projects: GA ČR GAP401/10/1164 Institutional support: RVO:67985955 Keywords : joint attention * anthropological difference * phenomenology * great apes * shared intentionality Subject RIV: AA - Philosophy ; Religion

  2. Educational differences in cardiovascular mortality

    DEFF Research Database (Denmark)

    Kjøllesdal, M. K. R.; Ariansen, I.; Mortensen, L. H.


    Aims: To explore the confounding effects of early family factors shared by siblings and cardiovascular risk factors in midlife on the educational differences in mortality from cardiovascular disease (CVD). Methods: Data from national and regional health surveys in Norway (1974–2003) were linked...

  3. Gender differences in entrepreneurial propensity

    NARCIS (Netherlands)

    Koellinger, P.; Minniti, M.; Schade, C.


    Using data from representative population surveys in 17 countries, we find that the lower rate of female business ownership is primarily due to women's lower propensity to start businesses rather than to differences in survival rates across genders. We show that women are less confident in their

  4. Gender Differences in Entrepreneurial Propensity

    NARCIS (Netherlands)

    Ph.D. Koellinger (Philipp); M. Minniti (Maria); C. Schade (Christian)


    textabstractUsing data from representative population surveys in 17 countries, we find that the lower rate of female business ownership is primarily due to women's lower propensity to start businesses rather than to differences in survival rates across genders. We show that women are less confident

  5. Structural Differences in Economic Growth

    NARCIS (Netherlands)

    N. Basturk (Nalan); R. Paap (Richard); D.J.C. van Dijk (Dick)


    textabstractThis paper addresses heterogeneity in determinants of economic growth in a data-driven way. Instead of defining groups of countries with different growth characteristics a priori, based on, for example, geographical location, we use a finite mixture panel model and endogenous clustering

  6. Different facets of market orientation

    DEFF Research Database (Denmark)

    Ormrod, Robert P.; Henneberg, Stephan C.


    two aims: firstly, we will discuss the different facets of the market orientation of the main UK and German parties in their respective 2005 General Elections through an exploratory content analysis, and secondly, we will compare characteristics of market orientation between the two countries. Whilst...

  7. Individual Differences in Learning Speed. (United States)

    Wang, Alvin Y.


    Three paired-associate learning studies were designed to test the hypothesis that individual differences in learning speed are determined by the types of elaborative strategies used by learners during acquisition. Slow learners generate fewer elaborators and produce less effective elaborators, even when using the same strategy as fast learners.…

  8. Sex differences in nicotine preference. (United States)

    Pogun, Sakire; Yararbas, Gorkem; Nesil, Tanseli; Kanit, Lutfiye


    Smoking is the major cause of preventable deaths worldwide, and although there is a decline in overall smoking prevalence in developed countries, the decline in women is less pronounced than in men. Women become dependent faster and experience greater difficulties in quitting. Similar trends have been observed in animal models of nicotine/tobacco addiction. Individual differences in vulnerability to drug abuse are also observed in nicotine/tobacco addiction and point to the importance of sex differences. This Review, summarizes findings from three experimental approaches used to depict nicotine preference in animal models, intravenous and oral nicotine self-administration and nicotine-induced conditioned place preference. Nicotine preference is considered to be reflected in the animal's motivation to administer the drug (intravenously or orally) or to prefer an environment paired with the presence of the drug (conditioned place preference). These approaches all point to the importance of sex and age of the subjects; the preference of females and adolescents appear to be more pronounced than that of males and adults, respectively. A closer look at these factors will help us understand the mechanisms that underlie nicotine addiction and develop strategies to cope. Ignoring sex differences and reaching conclusions based only on studies using male subjects has resulted in erroneous generalizations in the past. Sex differences in nicotine preference have been clearly documented, and awareness on this aspect of nicotine dependence will significantly impact our success in translational research. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  9. Different perspectives on economic base. (United States)

    Lisa K. Crone; Richard W. Haynes; Nicholas E. Reyna


    Two general approaches for measuring the economic base are discussed. Each method is used to define the economic base for each of the counties included in the Interior Columbia Basin Ecosystem Management Project area. A more detailed look at four selected counties results in similar findings from different approaches. Limitations of economic base analysis also are...

  10. Gender differences in spatial cognition

    NARCIS (Netherlands)

    de Goede, M.


    Spatial abilities, such as wayfinding and memorizing object locations, seem to be equally important for every individual. Yet both common belief and scientific literature claim that men and women differ in these abilities. Whereas ‘spatial ability’ used to be considered as a unitary capacity, on

  11. Country differences in sustainable consumption

    DEFF Research Database (Denmark)

    Thøgersen, John


    on a specific case: organic food consumption. The analyzed data are published research on why consumer purchase of organic food products differs between countries. As expected, organic food's share of total food consumption depends heavily on political regulation, including legal definitions and standards...

  12. A fast fractional difference algorithm

    DEFF Research Database (Denmark)

    Jensen, Andreas Noack; Nielsen, Morten Ørregaard


    We provide a fast algorithm for calculating the fractional difference of a time series. In standard implementations, the calculation speed (number of arithmetic operations) is of order T 2, where T is the length of the time series. Our algorithm allows calculation speed of order T log...

  13. A Fast Fractional Difference Algorithm

    DEFF Research Database (Denmark)

    Jensen, Andreas Noack; Nielsen, Morten Ørregaard

    We provide a fast algorithm for calculating the fractional difference of a time series. In standard implementations, the calculation speed (number of arithmetic operations) is of order T 2, where T is the length of the time series. Our algorithm allows calculation speed of order T log...

  14. On asymptotics for difference equations

    NARCIS (Netherlands)

    Rafei, M.


    In this thesis a class of nonlinear oscillator equations is studied. Asymptotic approximations of first integrals for nonlinear difference equations are constructed by using the recently developed perturbation method based on invariance vectors. The asymptotic approximations of the solutions of the

  15. The retrograde P-wave theory: explaining ST segment depression in supraventricular tachycardia by retrograde AV node conduction. (United States)

    Rivera, Santiago; De La Paz Ricapito, Maria; Conde, Diego; Verdu, Mariano Badra; Roux, Jean François; Paredes, Félix Ayala


    Pseudo ischemic ST segment changes during supraventricular tachycardia (SVT) are not yet fully understood. Our aim was to determine whether venticulo-atrial (VA) conduction during SVT may be a possible mechanism for ST depression (STd) in SVT. Patients undergoing SVT ablation (2010-2012) were analyzed (n = 72).Typical atrioventricular node reentrant tachycardia (AVNRT) and atrioventricular reentrant tachycardia (AVRT) were included. Those with STd were compared to those without STd. VA interval length, tachycardia cycle length (TCL), and retrograde P-wave activation during SVT were assessed. Retrograde P waves arriving simultaneously with the ST segment (PWST) during SVT were considered, whenever an atrial electrogram (measured from the high right atrium) was "on time" with the ST segment. Patients with STd during SVT presented longer VA intervals than those without STd (VA 100 ± 37 ms vs VA 69 ± 22 ms; P = 0.006). No differences in TCL were observed (TCL 333 ± 35 ms vs TCL 360 ± 22 ms; P = 0.1). PWST was observed in 38.5% of patients with AVNRT and STd versus 0% in those without STd. The TCL was similar in both groups (355 ± 25 ms vs 334 ± 18 ms; P = 0.1). In patients with AVRT and STd, PWST was present in 81% of cases versus 0% in those without STd. The TCL was also similar (330 ± 29 ms vs 346 ± 17 ms; P = 0.1). STd during SVT is observed at long VA intervals when the retrograde P wave matches the ST segment, without dependence on the TCL. This suggests that STd is not necessarily rate dependent but a result of a fusion between the ST segment and the P wave. ©2014 Wiley Periodicals, Inc.

  16. Business English teaching: different approaches for different needs

    Directory of Open Access Journals (Sweden)

    Orlando Vian Jr.


    Full Text Available This text aims at discussing possible approaches to teaching English for Business in professional contexts and in economics, business administration and accounting under graduation courses based on learners’ needs. Based on the Brazilian English for Specific Purposes scenario as well as on the notions of ‘approach’ and ‘need’, six different approaches are presented: task-based, deep end, case study, lexical, genre-based, focus on gambits and focus on business skills. Finally, materials and the applicability of such approaches to the contexts of practice are discussed.

  17. Interarm difference in blood pressure

    DEFF Research Database (Denmark)

    Mehlsen, Jesper; Wiinberg, Niels


    The present study aimed at examining the interarm difference in blood pressure and its use as an indicator of peripheral arterial disease (PAD). Data were included from consecutive patients referred from their general practitioner to our vascular laboratory for possible PAD aged 50 years or older...... without known cardiac disease, renal disease, or diabetes mellitus. 824 patients (453 women) with mean age of 72 years (range: 50-101) were included. 491 patients had a diagnosis of hypertension and peripheral arterial disease (PAD) was present in 386 patients. Systolic blood pressure was 143 ± 24 mm......Hg and 142 ± 24 mmHg on the right and left arm, respectively (P = 0.015). The interarm difference was greater in patients with hypertension (P = 0.002) and PAD (P blood pressure was reproducible...

  18. Difference, inclusion, and mathematics education

    DEFF Research Database (Denmark)

    Figueiras, Lourdes; Healy, Lulu; Skovsmose, Ole


    The round-table discussion on Difference, Inclusion and Mathematics Education was in included in the scientific programme of VI SIPEM in recognition and celebration of the emerging body of research into the challenges of building a culture of mathematics education which values and respects...... the diversity of learners in different educational contexts – in Brazil and beyond. This paper presents the contributions to the discussion, which focus on the problematisation of the term “inclusion”, explorations of how the practices of previously marginalized students can bring new resources to the teaching...... and learning of mathematics and reflections upon the potentially discriminatory nature of the structures which currently mould school mathematics. The paper aims to serve as material for the developing research agenda of the thirteenth working group of the Brazilian Society of Mathematics Education, which met...

  19. Systematic Differences and Random Rates

    DEFF Research Database (Denmark)

    Knudsen, Thorbjørn; Levinthal, Daniel A.; Winter, Sidney G.


    of quantity in the face of a downward sloping demand curve and recognition of their impact on the market price. If firms are subject to random firm-specific shocks, then in this equilibrium setting a population of such firms would generate a pattern of growth consistent with Gibrat’s law. However, if broader......A fundamental premise of the strategy field is the existence of persistent firm level differences in resources and capabilities. This property of heterogeneity should express itself in a variety of empirical “signatures,” such as firm performance and arguably systematic and persistent differences...... component, but for much of an industry’s and firm’s history should have a random pattern consistent with the Gibrat property. The intuition is as follows. In a Cournot equilibrium, firms of better “type” (i.e., lower cost) realize a larger market share, but act with some restraint on their choice...

  20. Sex differences in intimate relationships

    CERN Document Server

    Palchykov, Vasyl; Kertész, János; Barabási, Albert-László; Dunbar, Robin I M


    Social networks have turned out to be of fundamental importance both for our understanding human sociality and for the design of digital communication technology. However, social networks are themselves based on dyadic relationships and we have little understanding of the dynamics of close relationships and how these change over time. Evolutionary theory suggests that, even in monogamous mating systems, the pattern of investment in close relationships should vary across the lifespan when post-weaning investment plays an important role in maximising fitness. Mobile phone data sets provide us with a unique window into the structure of relationships and the way these change across the lifespan. We here use data from a large national mobile phone dataset to demonstrate striking sex differences in the pattern in the gender-bias of preferred relationships that reflect the way the reproductive investment strategies of the two sexes change across the lifespan: these differences mainly reflect women's shifting pattern...