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Sample records for satinder singh michael

  1. Remembering Daulat Singh Kothari .

    Directory of Open Access Journals (Sweden)

    Prem Kirpal

    1994-07-01

    Full Text Available When Dr Krishna of noble mien and resplendent culture puffed the last of his cigars and died suddenly in the Education Minister's room in the North Block where we were meeting for a discussion about the UGC Budget, the post of the Chairman fell vacant soon after CD Deshmukh had retired. I had run to fetch a doctor from the Health Ministry across the verandah, but the medical assistance was of no avail. In a few minutes the President, Dr Sarvepalli Radhakrishnan arrived and sadly we bade farewell to the remains of a great gentleman. The search for a new Chairman started soon, and while the one very hopeful candidate was on his way to the Prime Minister's House, Dr Radhakrishnan advised the Minister to announce the appointment of Daulat Singh Kotbari who was not in the running among several aspirants. The third Chairman of the recently constituted University Grants Commission on the lines of the British model, took office in 1961.

  2. Gensyn med Singh og Carpenter

    DEFF Research Database (Denmark)

    Skovgaard-Petersen, Henrik

    2014-01-01

    The article is a case comment on EU Court of Justice cases C-456/12, O & B and C-457/12, S & G. The article discusses the developments of the Singh and Carpenter doctrines resulting from the cases. It is argued that the personal scope of the doctrines now extends, in principle, to all Union...

  3. Gensyn med Singh og Carpenter

    DEFF Research Database (Denmark)

    Skovgaard-Petersen, Henrik

    2014-01-01

    The article is a case comment on EU Court of Justice cases C-456/12, O & B and C-457/12, S & G. The article discusses the developments of the Singh and Carpenter doctrines resulting from the cases. It is argued that the personal scope of the doctrines now extends, in principle, to all Union...... citizens. It is noted that the Court has clarified several aspects of the substantive scope of the doctrines; yet further clarification will be needed. The judgments confirm the resilience of the "purely internal" doctrine; however, the field remains a complex one owing to the incremental case law...

  4. Michael Thonet

    Index Scriptorium Estoniae

    2005-01-01

    Saksa päritolu austria mööblidisaineri ja mööblitöösturi Michael Thonet' (1796-1871) disainiloomingust. 1859. a. Michael Thonet' loodud tool nr. 14 on endiselt tootmises ja on tuntud ka Viini toolina. 2 ill

  5. Michael Thonet

    Index Scriptorium Estoniae

    2005-01-01

    Saksa päritolu austria mööblidisaineri ja mööblitöösturi Michael Thonet' (1796-1871) disainiloomingust. 1859. a. Michael Thonet' loodud tool nr. 14 on endiselt tootmises ja on tuntud ka Viini toolina. 2 ill

  6. Michael Schwantzer

    Institute of Scientific and Technical Information of China (English)

    ROGERZHANG

    2004-01-01

    In the seven years that he has been in China, German-native Michael, Schwantzer has found himself at the sharp end of business,building up a successful enterprise from humble beginnings in a highly competitive market. Michael initially came to China in 1997 to run a Sino-German joint venture supplying the shipbuilding industry in Nanjing. Two years later he joined LAP, starting the company's China operations. Within two years he had helped bring LAP's annual China sales from zero to US$ 5 million, in part through his extensive contacts within the steel industry.Based in Shanghai, where he lives with his wife and two children, Michael has caught the China-bug and has no plans to return to his native Germany. “Why would I?” he says.“Shanghai is the place to be right now.”

  7. Michael Scott

    Directory of Open Access Journals (Sweden)

    Ersin Hussein

    2015-04-01

    Full Text Available Associate Professor Michael Scott is a researcher and lecturer based in the department of Classics and Ancient History at the University of Warwick. He is also President of the Lytham St Annes Classical Association. Prior to his appointment at Warwick, Michael was the Moses and Mary Finley Research Fellow in ancient history at Darwin College, as well as an Affiliated Lecturer in the Faculty of Classics, at Cambridge University.Michael's research and teaching engages with interdisciplinary approaches to the literary, epigraphic and material evidence to investigate ancient Greek and Roman society, particularly focusing on Delphi and Olympia as religious spaces.While Michael has contributed significantly to the field of classics and ancient history by publishing extensively, he has also enjoyed great success in engaging wider audiences with the ancient world. He regularly talks in schools around the country, writes books intended for the popular market as well as articles for national and international newspapers and magazines. Michael's experience in writing and presenting a range of programmes intended for TV and radio audiences has made him a household name. He has written and presented programmes for the National Geographic, History Channel, Nova, and the BBC including Delphi: bellybutton of the ancient world (BBC4; Guilty Pleasures: luxury in the ancient and medieval words (BBC4; Jesus: rise to power (Natural Geographic; Ancient Discoveries (History Channel; Who were the Greeks? (BBC2; The Mystery of the X Tombs (BBC2/Nova; The Greatest Show on Earth (BBC4, in conjunction with the Open University. He has also presented a radio series for BBC Radio 4, Spin the Globe. Michael's most recent programme, Roman Britain from the Air, was aired on ITV in December 2014.In this interview, I talk to him about his engagement with other disciplines within the humanities, his forthcoming book project, and his experiences writing and presenting TV and radio

  8. Michael Jordan

    Institute of Scientific and Technical Information of China (English)

    汪仙美

    2000-01-01

    Many of us know Michael Jordan is a famous American basketball star. He is perhaps the greatest player in basketball history. Jordan is 1.98m tall. He plays guard(后卫)for the Chicago Bulls. He led his team to six NBA(National Basketball Association ) championships (冠军4).

  9. Conference held in Memory of U. N. Singh

    CERN Document Server

    Singh, D

    1992-01-01

    From the Contents: A. Lambert: Weighted shifts and composition operators on L2; - A.S.Cavaretta/A.Sharma: Variation diminishing properties and convexityfor the tensor product Bernstein operator; - B.P. Duggal: A note on generalised commutativity theorems in the Schatten norm; - B.S.Yadav/D.Singh/S.Agrawal: De Branges Modules in H2(Ck) of the torus; - D. Sarason: Weak compactness of holomorphic composition operators on H1; - H.Helson/J.E.McCarthy: Continuity of seminorms; - J.A. Siddiqui: Maximal ideals in local Carleman algebras; - J.G. Klunie: Convergence of polynomials with restricted zeros; - J.P. Kahane: On a theorem of Polya; - U.N. Singh: The Carleman-Fourier transform and its applications; - W. Zelasko: Extending seminorms in locally pseudoconvex algebras;

  10. Along the Grand Trunk Road: The Photography of Raghubir Singh

    Directory of Open Access Journals (Sweden)

    Chaya Chandrasekhar

    2013-05-01

    Full Text Available For more than two millennia, the historic Grand Trunk Road, the busy thoroughfare that extends some 1500 miles through north India and Pakistan served as the main artery of South Asia. It was also the gateway through which waves of immigrants, travelers, and invaders entered the subcontinent. As a result, a great deal of diversity and tolerance marks the road. Between 1988 and 1991, Raghubir Singh (1942-1999, one of India’s renowned documentary photographers, traveled and photographed the Indian stretch of the Road. Ninety-six photographs from his journeys appear in the publication, 'The Grand Trunk Road: A Passage Through India '(1995. Singh used the pictorial style of street photography that he is known for to capture everyday life along the path. Further, he emphasized the tremendous diversity he witnessed along the road through the selections he made for inclusion in the book and the specific manner in which he arranged many of them. By underscoring the heterogeneity, Singh provided a critical visual commentary of the political climate in India during the 1980s and early nineties. This period coincided with the rise of Hindu nationalism, which aimed to erase the subcontinent’s diverse past and promote instead the idea of a homogenous/Hindu India. By documenting the road in his uniquely pictorial style and arranging the photographs in his book to draw attention to the differences and tolerance witnessed along the path, Singh demonstrated that India was not a monolithic culture as the politics of the time claimed, but a rich interwoven fabric of many varied strands.

  11. PROFESSOR TEJ PAL SINGH: THE LEGEND OF INDIAN MACROMOLECULAR CRYSTALLOGRAPHY

    Directory of Open Access Journals (Sweden)

    Md. Imtaiyaz Hassan

    2013-12-01

    Full Text Available Professor Tej Pal Singh, an internationally recognized Indian scientist par excellence, is one of the pioneers of Indian macromolecular crystallography. He is a person of significant and enduring accomplishments as a teacher, scientist, administrator and family man. He has developed various methods to crystallize wide varieties of proteins. He has successfully determined crystal structures of lactoferrin, phospholipase A2, lactoperoxidase, peptidoglycan recognition proteins, disintegrin, zinc-α2-glycoprotein and several others including various protein-ligand and protein-protein complexes. He has a remarkably high number of structural entries in protein data bank. He received most of the prestigious awards and honors by Indian Government. This article covers most of his research and other achievements which will be a source of inspiration for young scientific community, motivation for peers and joy for his fellow colleagues and friends.

  12. Award for Distinguished Early Career Contributions to Psychology in the Public Interest: Anneliese A. Singh.

    Science.gov (United States)

    2016-11-01

    The APA Awards for Distinguished Contributions to Psychology in the Public Interest recognize persons who have advanced psychology as a science and/or profession by a single extraordinary achievement or a lifetime of outstanding contributions in the public interest. The 2016 corecipient of the Award for Distinguished Early Career Contributions to Psychology in the Public Interest is Anneliese A. Singh. Dr. Singh's scholarship "has promoted major advancements in LBGT studies and intersectionality of multiple identities." Singh's award citation, biography, and a selected bibliography are presented here. (PsycINFO Database Record

  13. PADMA SHRI CHARANJEET SINGH AN EMINENT SPORTS PERSONALITY- A CASE STUDY

    Directory of Open Access Journals (Sweden)

    Gurcharan Singh Brar

    2010-08-01

    Full Text Available The purpose of this research project is to highlight the qualities of Mr. Charanjeet Singh, which would serve as an example to the people connected with the promotion of physical education and sports within India.The data/ information for investigation was derived from Primary sources such as personal record, interview of Mr. Charanjeet Singh, pictorial records, published material and from secondary sources. A survey was used to obtain responses and reaction about Mr. Charanjeet Singh around about 100 selected eminent athletes, contemporaries, coaches and physical Educationist from all over the country through opinion rating questionnaire to get desired information. The investigation revealed that Mr. Charanjeet Singh started to playhockey at class VI. He was the captain of Indian hockey team which won gold medal in 1964 Olympic at Tokyo and played number of international and national hockey tournaments. He has been conferred with many awards and honours. The opinion rating survey indicated that Mr. Charanjeet Singh bears a very pleasant personality,health conscious, regular in his daily exercise and has a good physique. He merely loses his cool and has a lot of patience and perseverance. He has tremendous ability to overcome obstacles and his attitude towards others is very friendly and co-operative. Charanjeet Singh is one the great players in India and is proud of his country. He is a role model for others.

  14. Following Michael Faraday's Footprints

    Science.gov (United States)

    Galeano, Javier

    2011-01-01

    Last fall I had the good fortune of receiving financial support to shoot a documentary about Michael Faraday. I took the opportunity to learn more about this great experimentalist and to visit the highlights of places in his life. In this paper, I would like to share a list and description of some of the most remarkable places in London suitable…

  15. Michael Faraday's Bicentenary.

    Science.gov (United States)

    Williams, L. Pearce; And Others

    1991-01-01

    Six articles discuss the work of Michael Faraday, a chemist whose work revolutionized physics and led directly to both classical field and relativity theory. The scientist as a young man, the electromagnetic experiments of Faraday, his search for the gravelectric effect, his work on optical glass, his laboratory notebooks, and his creative use of…

  16. Michael Faraday, media man.

    Science.gov (United States)

    Fara, Patricia

    2006-03-01

    Michael Faraday was an enthusiastic portrait collector, and he welcomed the invention of photography not only as a possible means of recording observations accurately, but also as a method for advertising science and its practitioners. This article (which is part of the Science in the Industrial Revolution series) shows that like many eminent scientists, Faraday took advantage of the burgeoning Victorian media industry by posing in various roles.

  17. Michael Learns to Rock

    Institute of Scientific and Technical Information of China (English)

    汪海涛

    2004-01-01

    夜幕降临.空气中传来北欧的声音,来自丹麦的四人流行乐队Michael Learns to Rock(迈克学摇滚)正把探情款款的歌声带到上海的咖啡厅和酒吧。北欧一直活跃着一批世界顶级的乐队.从丹麦的A-Ha到Aqua,从瑞典的ABBA到Roxette和Ace of Base,从挪威的Se

  18. Michael Frayn visits CERN

    CERN Document Server

    2007-01-01

    Award-winning playwright and novelist Michael Frayn gave a guest lecture in the main auditorium at CERN on Friday 15 March about his new book The Human Touch: Our Part in the Creation of the Universe. The lecture focused on cosmology and philosophy and the limitations that language places on our ability to understand the creation of a universe in which we seem to play such a small part. In addition to his novels and plays, which include Copenhagen, a play about the 1941 meeting between German physicist Werner Heisenberg and Danish physicist Niels Bohr, Frayn has translated several works from Russian, including plays by Chekhov and Tolstoy.

  19. Print and Electronic Resources: Usage Statistics at Guru Gobind Singh Indraprastha University Library

    Science.gov (United States)

    Kapoor, Kanta

    2010-01-01

    Purpose: The purpose of this paper is to quantify the use of electronic journals in comparison with the print collections in the Guru Gobind Singh Indraprastha University Library. Design/methodology/approach: A detailed analysis was made of the use of lending services, the Xerox facility and usage of electronic journals such as Science Direct,…

  20. Print and Electronic Resources: Usage Statistics at Guru Gobind Singh Indraprastha University Library

    Science.gov (United States)

    Kapoor, Kanta

    2010-01-01

    Purpose: The purpose of this paper is to quantify the use of electronic journals in comparison with the print collections in the Guru Gobind Singh Indraprastha University Library. Design/methodology/approach: A detailed analysis was made of the use of lending services, the Xerox facility and usage of electronic journals such as Science Direct,…

  1. Jaap Sahib : The Cosmology of Guru Gobind Singh -Translated into English and French Verse

    Science.gov (United States)

    Gill, Daneille; Gill, Harjeet Singh

    In this cosmology, Guru Gobind Singh presents a correspondence and concordance between the physical and the metaphysical, between the secular and the spiritual. It presents a possibility that can revolutionise the whole historical progression of mankind. (With Text in Original Gurumukhi Script and Roman Transliteration).

  2. The Role of Contrast in the Perception of Achromatic Transparency: Comment on Singh and Anderson (2002) and Anderson (2003)

    Science.gov (United States)

    Albert, Marc K.

    2008-01-01

    M. Singh and B. L. Anderson proposed a perceptual theory of achromatic transparency in which the perceived transmittance of a perceived transparent filter is determined by the ratio of the Michelson contrast seen in the region of transparency to that of the background seen directly. Subsequently, B. L. Anderson, M. Singh, and J. Meng proposed that…

  3. Professor Michael Levitt

    Directory of Open Access Journals (Sweden)

    Gemma-Louise Davies

    2015-10-01

    Full Text Available Professor Michael Levitt (Stanford University, USA won the 2013 Nobel Prize in Chemistry for the development of multiscale models for complex chemical systems—computational tools which can calculate the course of chemical reactions. Professor Levitt was born in Pretoria, South Africa; he came to the UK on a summer vacation aged 16, where he decided to stay and study for his A‑levels. His interest in the physics of living systems drove him to study biophysics at King’s College London, before securing a PhD position at the Laboratory of Molecular Biology in Cambridge. In the interim year between his degree and beginning his PhD, Professor Levitt worked at the Weizmann Institute of Science in Israel, where he met his future wife. They married later that year and moved to Cambridge, where their three children were born. After completing his PhD, he spent time working in Israel, Cambridge, the Salk Institute and Stanford (both California. Since 1986, he has split his time between Israel and California. Outside of science, he is a keen hiker and he is well-known to have attended the eclectic ‘Burning Man’ Festival in California.[1]Professor Levitt visited the University of Warwick to speak at the Computational Molecular Science Annual Conference in March 2015. In this interview, Dr Gemma-Louise Davies, an Institute of Advanced Study Global Research Fellow, spoke to Professor Levitt about the importance of Interdisciplinarity in his field, role models in Academia, and his plans for the future.Image: Professor Michael Levitt (left with Dr Scott Habershon (right, organiser of the 2015 Computational Molecular Science Annual Conference during his visit to the University of Warwick in March 2015.[1] ‘Burning Man’ is a unique annual festival dedicated to community, art, music, self-expression and self-reliance. Tens of thousands of people flock to this temporary metropolis built in the Californian desert.

  4. Enantioselective Michael Addition of Water

    NARCIS (Netherlands)

    Chen, B.S.; Resch, V.; Otten, L.G.; Hanefeld, U.

    2014-01-01

    The enantioselective Michael addition using water as both nucleophile and solvent has to date proved beyond the ability of synthetic chemists. Herein, the direct, enantioselective Michael addition of water in water to prepare important β-hydroxy carbonyl compounds using whole cells of Rhodococcus st

  5. Interview with Michael Gazzaniga.

    Science.gov (United States)

    Gazzaniga, Michael

    2011-04-01

    Widely considered the father of the field of cognitive neuroscience, Professor Michael S. Gazzaniga is one of the world's premier neuroscientists. He founded the Center for Neuroscience at the University of California, Davis; the Center for Cognitive Neuroscience at Dartmouth College; the Cognitive Neuroscience Institute; Journal of Cognitive Neuroscience; and the Cognitive Neuroscience Society. He is currently the director of the Sage Center for the Study of the Mind at the University of California, Santa Barbara. Born on December 12, 1939 in Los Angeles and educated at Dartmouth College, he received his Ph.D. in psychobiology at the California Institute of Technology under the tutelage of Roger Sperry. As a graduate student, Professor Gazzaniga initiated the first lateralized testing of human split-brain patients, leading to a fundamental shift in our understanding of functional lateralization in the brain and how the cerebral hemispheres communicate with one another. His many scholarly publications and pioneering work during the last 50 years have produced significant contributions to our understanding of how the brain enables the mind. His landmark 1995 book for MIT Press, The Cognitive Neurosciences, now in its fourth edition, is recognized as the sourcebook for the field. He has also published many books accessible to a lay audience, including Mind Matters, Nature's Mind, and The Ethical Brain.

  6. Q&A: Michael Honey

    Science.gov (United States)

    Helicher, Karl

    2007-01-01

    The mid-1960s saw civil rights victories in Congress during Lyndon B. Johnson's presidency. In "Going Down Jericho Road," Michael Honey wrote how Martin Luther King Jr.'s final focus showed that the struggle for black and working class parity continued. The 1968 Memphis sanitation workers strike was a gritty struggle won in the streets by a host…

  7. Michael Beitz: Objects of Communication

    Science.gov (United States)

    Hoefferle, Mary

    2014-01-01

    For this Instructional Resource, the author interviewed contemporary sculptor Michael Beitz, who uses art to explore the role of designed objects in human communication and emotional experience. This column was written in response to calls for using Enduring Understandings/Big Ideas (National Coalition for Core Arts Standards, 2013; Stewart &…

  8. Michael J. Fox: Spurring Research on Parkinson's

    Science.gov (United States)

    ... please turn JavaScript on. Feature: Parkinson's Disease Michael J. Fox: Spurring Research on Parkinson's Past Issues / Winter 2014 Table of Contents Michael J. Fox and his wife, actress Tracy Pollan, founded ...

  9. Michael Faraday vs. the Spiritualists

    Science.gov (United States)

    Hirshfeld, Alan

    2006-12-01

    In the 1850s, renowned physicist Michael Faraday launched a public campaign against pseudoscience and spiritualism, which were rampant in England at the time. Faraday objected especially to claims that electrical or magnetic forces were responsible for paranormal phenomena, such as table-spinning and communication with the dead. Using scientific methods, Faraday unmasked the deceptions of spiritualists, clairvoyants and mediums and also laid bare the credulity of a public ill-educated in science. Despite his efforts, Victorian society's fascination with the paranormal swelled. Faraday's debacle anticipates current controversies about public science education and the interface between science and religion. This episode is one of many described in the new biography, The Electric Life of Michael Faraday (Walker & Co.), which chronicles Faraday's discoveries and his unlikely rise from poverty to the pinnacle of the English science establishment.

  10. Michael Niegl (1985-2009)

    CERN Multimedia

    2009-01-01

    Our friend and colleague Michael Niegl died in a tragic accident in the first hours of the new year. Michael was a Master’s student in Microsystems Engineering at the University of Applied Sciences Wiener Neustadt. He was responsible for the development of the ATLAS Beam Conditions Monitor (BCM) ROD FPGA firmware, which acquires the data from the BCM detector modules and provides online monitoring of the LHC beams within the ATLAS experiment. He spent several months at CERN to carry out beam tests on the BCM detectors and received his Bachelor of Science with first class honours for his thesis: Concept and Implementation of an FPGA-based Data Recorder and Processor for the ATLAS Beam Conditions Monitor. Michael spent six months at CERN last year to finish the development and commissioning of the ROD firmware for the first beam. He worked the entire night of 10 September to fine tune the system for the first beam. It was a joy to ...

  11. Michael De Sousa (1989 - 2012)

    CERN Multimedia

    2012-01-01

    We are deeply saddened to announce the death of Mr Michael De Sousa on 13 May 2012. Mr De Sousa, who was born on 02.09.1989, was working as an apprentice in the TE Department and had been at CERN since 24.08.2009. The Director-General has sent a message of condolence to his family on behalf of the CERN personnel. Social Affairs Human Resources Department     It is with great emotion and deep sadness that we learn of the tragic loss of our colleague and friend Michael De Sousa. Michael was a hard working colleague, cordial and considerate. Within a few months, he marked his presence by the implementation of the instrumentation benches for gas permeation measurement in polymers, and the calibration of high technology gas analyzers, necessary for vacuum technology. His last contribution will enable us to measure pressures in the extreme high vacuum range for the ELENA project.  With the continuation of this activity, his memory will remain. His accomplishments will remain...

  12. Organocatalytic aza-Michael/retro-aza-Michael reaction: pronounced chirality amplification in aza-Michael reaction and racemization via retro-aza-Michael reaction.

    Science.gov (United States)

    Cai, Yong-Feng; Li, Li; Luo, Meng-Xian; Yang, Ke-Fang; Lai, Guo-Qiao; Jiang, Jian-Xiong; Xu, Li-Wen

    2011-05-01

    A detailed experimental investigation of an aza-Michael reaction of aniline and chalcone is presented. A series of Cinchona alkaloid-derived organocatalysts with different functional groups were prepared and used in the aza-Michael and retro-aza-Michael reaction. There was an interesting finding that a complete reversal of stereoselectivity when a benzoyl group was introduced to the cinchonine and cinchonidine. The chirality amplification vs. time proceeds in the quinine-derived organocatalyst containing silicon-based bulky group, QN-TBS, -catalyzed aza-Michael reaction under solvent-free conditions. In addition, we have demonstrated for the first time that racemization was occurred in suitable solvents under mild conditions due to retro-aza-Michael reaction of the Michael adduct of aniline with chalcone. These indicate the equilibrium of retro-aza-Michael reaction and aza-Michael reaction produce the happening of chirality amplification in aza-Michael reaction and racemization via retro-aza-Michael reaction under different conditions, which would be beneficial to the development of novel chiral catalysts for the aza-Michael reactions.

  13. Applications of Singh-Rajput Mes in Recall Operations of Quantum Associative Memory for a Two- Qubit System

    Science.gov (United States)

    Singh, Manu Pratap; Rajput, B. S.

    2016-03-01

    Recall operations of quantum associative memory (QuAM) have been conducted separately through evolutionary as well as non-evolutionary processes in terms of unitary and non- unitary operators respectively by separately choosing our recently derived maximally entangled states (Singh-Rajput MES) and Bell's MES as memory states for various queries and it has been shown that in each case the choices of Singh-Rajput MES as valid memory states are much more suitable than those of Bell's MES. it has been demonstrated that in both the types of recall processes the first and the fourth states of Singh-Rajput MES are most suitable choices as memory states for the queries `11' and `00' respectively while none of the Bell's MES is a suitable choice as valid memory state in these recall processes. It has been demonstrated that all the four states of Singh-Rajput MES are suitable choice as valid memory states for the queries `1?', `?1', `?0' and `0?' while none of the Bell's MES is suitable choice as the valid memory state for these queries also.

  14. Stay the Night: Meera Margaret Singh at the Gladstone Hotel Stay the Night : Meera Margaret Singh à l’hôtel Gladstone

    Directory of Open Access Journals (Sweden)

    Kerry Manders

    2012-07-01

    Full Text Available This essay examines Meera Margaret Singh’s exhibition Nightingale in the time and place of the liminal space we call “hotel.” In intertexual dialogue with Wayne Koestenbaum’s Hotel Theory, the author not only reviews Singh’s intimate photographs of her mother, she reads the images with and against the architecture in which they are exhibited. The Gladstone as exhibition space redoubles Singh’s emphasis on the tense connectivity of apparent binaries: youth and age, public and private, artist and model, object and spectator, living and dying. The quotidian activities of hotel living—guests’ arrivals, departures, and returns—become inextricable pieces of Singh’s site-specific installation. The author theorizes what Freud calls the “foretaste of mourning” in this work, grappling with what will be but is not yet the death of the mother. Singh’s Nightingale proposes that we do not “work through” mourning: mourning is a perpetual way of being in the present.Cet article examine l’exposition photographique de Meera Margaret Singh dans l’espace liminal qu’est l’hôtel. En dialogue intertextuel avec l’œuvre de Wayne Koestenbaum, Hotel Theory, l’auteur examine les portraits intimes de la mère de la photographe, tout en les lisant en fonction de l’architecture de leur emplacement. L’hôtel Gladstone en tant que lieu d’exposition redouble donc l’accent que met la photographe sur les liens tendus des systèmes binaires apparents: la jeunesse et l’âge ; le public et le privé ; l’artiste et le modèle ; l’objet et le spectateur; vivre et mourir. Les activités quotidiennes de la vie en hôtel – l’arrivée, le départ, et le retour d’invités – deviennent des éléments inextricables de l’œuvre in situ. L’auteur théorise le concept de Freud sur l’avant-goût du deuil, explorant ce qui deviendra mais ne l’est pas encore : la mort de la mère. Cette exposition propose que nous ne

  15. Video interview with Michael Dell

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    Michael Dell, founder and presently Chairman of the Board of Directors and Chief Executive Office of the DELL computer company visited CERN on Tuesday 26th January 2010. The Bulletin and the Video productions team had the opportunity to meet him. The video interview is transcribed for your convenience.   Michael S. Dell with CERN Director-General Rolf Heuer. What motivated you to come and visit CERN? I obviously heard about the great science and research has going on here, and DELL is very pleased to be a partner and providing a lot of the computers to analyse the data and I really wanted to see for myself in person, some of the great science that is going on here. What is your view on fundamental research in IT, and in general? I think if you look at the field of science in the last hundred years, we have been able to solve a lot of problems, but there are still lots of unsolved problems and unsolved mysteries. And it is only through basic fundamental research that we will address these probl...

  16. Evaluation of Singh index for assessment of osteoporosis using digital radiography

    Energy Technology Data Exchange (ETDEWEB)

    Hauschild, O. [Department of Orthopaedic Surgery and Traumatology, University Medical Center Freiburg (Germany)], E-mail: oliver.hauschild@uniklinik-freiburg.de; Ghanem, N. [Department for Diagnostic Radiology, University Medical Center Freiburg (Germany)], E-mail: nadir.ghanem@uniklinik-freiburg.de; Oberst, M. [Department of Orthopaedic Surgery and Traumatology, University Medical Center Freiburg (Germany)], E-mail: michael.oberst@uniklinik-freiburg.de; Baumann, T. [Department for Diagnostic Radiology, University Medical Center Freiburg (Germany)], E-mail: tobias.baumann@uniklinik-freiburg.de; Kreuz, P.C. [Department of Orthopaedic Surgery and Traumatology, University Medical Center Freiburg (Germany)], E-mail: peter.kreuz@uniklinik-freiburg.de; Langer, M. [Department for Diagnostic Radiology, University Medical Center Freiburg (Germany)], E-mail: mathias.langer@uniklinik-freiburg.de; Suedkamp, N.P. [Department of Orthopaedic Surgery and Traumatology, University Medical Center Freiburg (Germany)], E-mail: norbert.suedkamp@uniklinik-freiburg.de; Niemeyer, P. [Department of Orthopaedic Surgery and Traumatology, University Medical Center Freiburg (Germany)], E-mail: philipp.niemeyer@uniklinik-freiburg.de

    2009-07-15

    Evaluation of Singh index (SI) as a simple means for estimating bone mass on radiographs has been subject of numerous studies. All of these studies used plain film radiographs for assessment of SI. Digital radiography may improve validity and reliability of SI assessment. Aim of this study was to evaluate SI gradings assessed on digital radiographs. Digital pelvic radiographs of 100 patients were graded using SI by five independent observers (two radiologists, three traumatologists) blinded to dual energy X-ray absorptiometry (DXA) results and re-graded by all observers for assessment of intraobserver agreement. SI was correlated with DXA measurements and after grouping the patients according to World Health Organisation (WHO) criteria (osteoporosis, osteopenia, normal). Logistic regression analysis was performed in order to identify influential parameters on the SI grading process. Mean intraobserver agreement was 0.648 {+-} 0.18 (Kendall's Tau) and 0.43 {+-} 0.28 (kappa). Mean interobserver agreement was 0.488 {+-} 0.193 (Kendall's Tau) and 0.199 {+-} 0.248 (kappa). Mean correlation between SI and trochanteric BMD and T scores was 0.219 {+-} 0.04 and 0.210 {+-} 0.05 (Spearman's coefficient). Only one observer (senior radiologist) reached the significance level after grouping the patients' DXA results according to WHO criteria and correlating the results with SI gradings. Logistic regression analysis revealed a significant influence of trochanteric T score in two observers while other variable parameters failed to reach the significance level. Even though we found reasonable intraobserver agreement assessment of SI is highly subjective and interobserver agreement is generally poor. Moreover, using digital radiography could not improve correlation with DXA measurements.

  17. PROVIDING AFFORDABLE HIGHER EDUCATION TO RURAL GIRLS IN INDIAN PUNJAB: A CASE STUDY OF BABA AYA SINGH RIARKI COLLEGE

    Directory of Open Access Journals (Sweden)

    RANJIT SINGH GHUMAN

    2013-12-01

    Full Text Available The paper highlights a case study of a rural girls college located in a remote village of Gurdaspur district in Indian Punjab. The idea of this unique college was conceptualised by one Baba Aya Singh, a social and religious activist, from a village near the college way back in 1925. It was really a revolutionary idea because female education in India, particularly higher education, was a distant dream at that time. The college was, however, started with only 14 rural girls after about half-a-century when the great visionary Baba Aya Singh had a dream to educate the rural girls. Access to and affordability of higher education is the uniqueness of this college. The student has to pay only Rs. 5800 (about US $ 65 per annum, which includes both the tuition fee and boarding and lodging. It is equally significant to note that the entire expenses of the college are met by this and the produce of agricultural land of the college. The college does not take any outside help. The meritorious senior class students teach the junior class students. The college in its own humble, but significant, way made a revolutionary contribution to the education of poor rural girls who, otherwise, would not have dreamt of college education. Apart from, class-room teaching and bookish knowledge, the students are taught social, ethical and management skills in a most natural manner. The product of the college has proved to be the agents of change and rural transformation.

  18. Michael Wood’s Yangzhou Dream

    Institute of Scientific and Technical Information of China (English)

    Yuan; Dan

    2014-01-01

    <正>Mr.Michael Wood is a wellknown British historian and documentary maker who has produced more than a hundred documentaries on various national histories and cultures exemplified by The Story of India.They enjoy wide popularity in more than 150 countries.I met him in February when he took his fi lm crew to Yangzhou to shoot The Story of China documentary for the British Broadcasting Corporation(BBC).It was a snowy day,cold and wet,but Michael said happily that the

  19. Michael Hauskeller: Sex and the Posthuman Condition

    NARCIS (Netherlands)

    Miller, Lantz Eugene

    2016-01-01

    This new book from Michael Hauskeller explores the currently marketed or projected sex/love products that exhibit some trait of so-called “posthumanistic” theory or design. These products are so designated because of their intention to fuse high technologies, including robotics and computing, with

  20. Michael Hauskeller: Sex and the Posthuman Condition

    NARCIS (Netherlands)

    Miller, Lantz Flemming

    2016-01-01

    This new book from Michael Hauskeller explores the currently marketed or projected sex/love products that exhibit some trait of so-called “posthumanistic” theory or design. These products are so designated because of their intention to fuse high technologies, including robotics and computing, with t

  1. Reframing Michael Scott: Exploring Inappropriate Workplace Communication

    Science.gov (United States)

    Schaefer, Zachary A.

    2010-01-01

    Individuals who work in professional settings interact with others who may exhibit a variety of cultural beliefs and decision-making approaches. Page (2007) argues that cognitive diversity (i.e., how people approach and attempt to solve problems) is a vital asset in effective organizations. Michael Scott, who portrays the inept main character on…

  2. Comments on Michael (1993): Establishing Operations

    Science.gov (United States)

    Moore, J.

    2013-01-01

    The present comments concern Michael's concept of motivative variables, and the implications of that concept for our understanding of the nature of reinforcement as well as the extinction of responses maintained through positive and negative reinforcement. We note that both extinction and altering motivative variables decrease responding, but…

  3. TIME CAPSULE: MICHAEL LUCHKOVICH AND THE FAMINE

    Directory of Open Access Journals (Sweden)

    Serge Cipko

    2013-05-01

    Full Text Available This paper examines the reaction of the Ukrainian community in Canada at the Ukrainian famine of 1932–1933 in particular highlights the activities member of parliament, a Ukrainian-born Michael Luchkovich which 5 February 1934 gave a speech in federal parliament, reporting on the famine in the USSR and the related this protest the Ukrainian diaspora.

  4. Reflections: Michael Watts interviewed by Murat Arsel

    NARCIS (Netherlands)

    M. Arsel (Murat)

    2009-01-01

    textabstractMichael Watts is ‘Class of 1963’ Chair in Undergraduate Studies and Chancellor’s Professor of Geography at the University of California, Berkeley. Born and raised in rural southwest England, Watts studied at University College London and completed his PhD in 1979 at the University of Mic

  5. Comments on the criticism of Sarvajit Singh on the paper ‘Surface waves in fibre-reinforced anisotropic elastic media’

    Indian Academy of Sciences (India)

    P R Sengupta; Sisir Nath

    2002-06-01

    Though the decoupling of displacement potentials in case of fibrereinfoced anisotropic elastic media is not possible in the general case, an attempt has been made to decouple the equation as a particular case. The assumptions made in this paper satisfy both set of equations formed by the displacement potentials, which is the main feature of the criticism made by Sarvajit Singh.

  6. Preliminary evaluation of Delphastus catalinae (Coleoptera:Coccinellidae)as a predator of the ficus whitefly, Singhiella simplex (Singh) (Hemiptera:Aleyrodidae)

    Science.gov (United States)

    The predatory lady beetle Delphastus catalinae (Horn) (Coleoptera: Coccinellidae) was evaluated as a potential biological control agent against the ficus whitefly, Singhiella simplex (Singh) (Hemiptera: Aleyrodidae), a newly-invasive pest of ficus plants. Adult D. catalinae females were starved for ...

  7. Michael Haneke film Euroopa parim / M. T.

    Index Scriptorium Estoniae

    M. T.

    2005-01-01

    IX PÖFFil linastuv Michael Haneke film "Varjatud" ("Cache") võitis laupäeval mitu Euroopa Filmiakadeemia auhinda, selhulgas parima filmi, parima lavastaja, parima meesnäitleja (Daniel Auteuil) ja FIPRESCI auhinna. Parim naisnäitleja - Julia Jentsch ("Sophie Scholli viimased päevad"), operaator - Franz Lustig ("Don't Come Knocking"), stsenaarium - Hany Abu-Assad, Bero Beyer ("Kohe paradiisi")

  8. STS-86 Pilot Michael Bloomfield suits up

    Science.gov (United States)

    1997-01-01

    STS-86 Pilot Michael J. Bloomfield relaxes for a moment while donning his launch and entry suit with the assistance of a suit technician in the Operations and Checkout Building. This will be Bloomfields first spaceflight. He and the six other crew members will depart shortly for Launch Pad 39A, where the Space Shuttle Atlantis awaits liftoff on a 10-day mission slated to be the seventh docking of the Space Shuttle with the Russian Space Station Mir.

  9. Comments on Michael (1993): Establishing Operations

    OpenAIRE

    Moore, J

    2013-01-01

    The present comments concern Michael's concept of motivative variables, and the implications of that concept for our understanding of the nature of reinforcement as well as the extinction of responses maintained through positive and negative reinforcement. We note that both extinction and altering motivative variables decrease responding, but they do so differently. The former does so by discontinuing the response-reinforcer relation. The latter does so by altering the motivation to respond. ...

  10. Michael Haneke film Euroopa parim / M. T.

    Index Scriptorium Estoniae

    M. T.

    2005-01-01

    IX PÖFFil linastuv Michael Haneke film "Varjatud" ("Cache") võitis laupäeval mitu Euroopa Filmiakadeemia auhinda, selhulgas parima filmi, parima lavastaja, parima meesnäitleja (Daniel Auteuil) ja FIPRESCI auhinna. Parim naisnäitleja - Julia Jentsch ("Sophie Scholli viimased päevad"), operaator - Franz Lustig ("Don't Come Knocking"), stsenaarium - Hany Abu-Assad, Bero Beyer ("Kohe paradiisi")

  11. Obituary: Michael James Ledlow, 1964-2004

    Science.gov (United States)

    Puxley, Philip John; Grashuis, Randon M.

    2004-12-01

    Michael James Ledlow died on 5 June 2004 from a large, unsuspected brain tumor. Since 2000 he had been on the scientific staff of the Gemini Observatory in La Serena, Chile, initially as a Science Fellow and then as a tenure-track astronomer. Michael was born in Bartlesville, Oklahoma on 1 October 1964 to Jerry and Sharon Ledlow. He obtained his Bachelor Degree in astrophysics at the University of Oklahoma in 1987 and attended the University of New Mexico for his graduate work, obtaining his PhD while studying Galaxy Clusters under Frazer Owen in 1994. From 1995-1997 Michael held a postdoctoral position with Jack Burns at New Mexico State University where he used various astronomical facilities including the VLA and Apache Point Observatory to study distant galaxies. From 1998-2000 Michael rejoined the Physics and Astronomy Department at the University of New Mexico where he was a visiting professor until he moved on to Gemini. At the Gemini Observatory, Mike shared in the excitement, hard work and many long days and nights associated with bringing on-line a major new astronomical facility and its instrumentation. Following its commissioning he assisted visiting observers, supported and took data for many more remote users via the queue system, and for each he showed the same care and attention to detail evident in his own research to ensure that all got the best possible data. His research concentrated on the radio and optical properties of galaxy clusters, especially rich Abell clusters such as A2125, on luminous radio galaxies, including the detection of a powerful double radio source in the "wrong sort of galaxy," the spiral system 0313-192, and on EROs (extremely red objects), dusty galaxies barely detectable at optical wavelengths. Michael thoroughly enjoyed living in Chile and enthusiastically immersed himself in the culture of his surroundings. He and his family were actively involved with the International English Spanish Association in La Serena. He had a

  12. A conversation with Michael Freeman, MD.

    Science.gov (United States)

    Freeman, M

    1994-12-01

    The Institute for Behavioral Healthcare, a nonprofit organization that serves as an informational resource on issues surrounding the delivery of Behavioral Health Care Services, has been directed by Dr. Michael Freeman since its inception in 1988. In this crucial, unstable period in health care, membership in the Institute and attendance at its sponsored meetings has increased dramatically. Recently, Medical Interface talked with Dr. Freeman about topics of interest to the behavioral health care industry, ranging from any willing provider laws to the benefit itself.

  13. Anne Michaels e le ferite del linguaggio

    Directory of Open Access Journals (Sweden)

    Oriana Palusci

    2014-04-01

    Fugitive Pieces is analysed taking into consideration its polyphonic structure, the manifold motives and threads that weave together an intricate pattern, based on historical events and personal stories. Thanks to her use of scientific language from the realm of geology, paleobotany and geography, Michaels excavates time and space, past and present, in order to find a language to unveil the atrocities of Nazism against Jews, to preserve and evoke the memories of the survivors, but at the same time lead to a possible reconciliation with the past.

  14. Richard Michael Suzman (1942-2015).

    Science.gov (United States)

    Kahneman, Daniel

    2016-01-01

    Presents an obituary for Richard Michael Suzman, who died on April 16, 2015. Suzman was trained as a sociologist and anthropologist, but he was attracted to the approaches of demography and economics. He came to know a great deal about diverse fields of science, including health, physiology, psychology, genetics, and economics. He was a scientific leader who was on a quest to develop new transdisciplinary fields and to mobilize the best scientists to work in them. Suzman's passion for transdisciplinary science was fully expressed in his greatest achievement: the famous Health and Retirement Survey (HRS), which he initiated in 1988 and continued to guide and inspire. (PsycINFO Database Record

  15. Michael Roitmann : Kalandus ei ole Eestile ilmselt prioriteetne valdkond / Michael Roitmann ; interv. Marko Saaret

    Index Scriptorium Estoniae

    Roitmann, Michael

    2003-01-01

    Ilmunud ka: Delovõje Vedomosti 3. dets. lk. 9. Euroopa Komisjoni kalandusdirektoraadi koordinaator Euroopa Liidu laienemise küsimuses Michael Roitmann juhib tähelepanu Eesti kalanduse suurematele probleemidele ning prognoosib EL-iga liitumise mõju Eesti kalandussektori arengule

  16. Michael Roitmann : Kalandus ei ole Eestile ilmselt prioriteetne valdkond / Michael Roitmann ; interv. Marko Saaret

    Index Scriptorium Estoniae

    Roitmann, Michael

    2003-01-01

    Ilmunud ka: Delovõje Vedomosti 3. dets. lk. 9. Euroopa Komisjoni kalandusdirektoraadi koordinaator Euroopa Liidu laienemise küsimuses Michael Roitmann juhib tähelepanu Eesti kalanduse suurematele probleemidele ning prognoosib EL-iga liitumise mõju Eesti kalandussektori arengule

  17. Michael Maier--nine newly discovered letters.

    Science.gov (United States)

    Lenke, Nils; Roudet, Nicolas; Tilton, Hereward

    2014-02-01

    The authors provide a transcription, translation, and evaluation of nine newly discovered letters from the alchemist Michael Maier (1568-1622) to Gebhardt Johann von Alvensleben (1576-1631), a noble landholder in the vicinity of Magdeburg. Stemming from the final year of his life, this correspondence casts new light on Maier's biography, detailing his efforts to secure patronage amid the financial crisis of the early Thirty Years' War. While his ill-fated quest to perfect potable gold continued to form the central focus of his patronage suits, Maier also offered his services in several arts that he had condemned in his printed works, namely astrology and "supernatural" magic. Remarks concerning his previously unknown acquaintance with Heinrich Khunrath call for a re-evaluation of Maier's negotiation of the discursive boundaries between Lutheran orthodoxy and Paracelsianism. The letters also reveal Maier's substantial contribution to a work previously ascribed solely to the English alchemist Francis Anthony.

  18. STS-97 Crew Interviews: Michael J. Bloomfield

    Science.gov (United States)

    2000-01-01

    Live footage of a preflight interview with Pilot Michael J. Bloomfield is shown. The interview addresses many different questions including why Bloomfield became interested in the space program, the events and people that influence him and ultimately led to his interest, and his vigorous training in the astronaut program. Other interesting information that this one-on-one interview discusses are the main goals of the STS-97 mission, its scheduled docking with the new International Space Station (ISS), and its delivery of the first set of U.S.-provided solar arrays, batteries, and radiators. Bloomfield briefly discusses his responsibilities during the much-anticipated docking as well as during the scheduled space-walks.

  19. Book Review: Invitation to Topological Robotics by Michael Farber

    DEFF Research Database (Denmark)

    Raussen, Martin

    2009-01-01

    Book Review: Invitaton to Topological Robotics by Michael Farber. Zurich Lectures in Advanced Mathematics, European Mathematical Society (2008), ISBN 978-3-03719-054-8......Book Review: Invitaton to Topological Robotics by Michael Farber. Zurich Lectures in Advanced Mathematics, European Mathematical Society (2008), ISBN 978-3-03719-054-8...

  20. Interview with Michael Apple: The Biography of a Public Intellectual

    Science.gov (United States)

    Peters, Michael A.

    2015-01-01

    Michael W. Apple is the John Bascom Professor of Curriculum and Instruction and Educational Policy Studies in the Departments of Curriculum and Instruction (CI) and Educational Policy Studies (EPS) at the University of Wisconsin-Madison School of Education where he has taught since 1970. Michael Apple is one of the foremost educational theorists…

  1. Michael J. Meaney: Award for Distinguished Scientific Contributions

    Science.gov (United States)

    American Psychologist, 2012

    2012-01-01

    Presents Michael J. Meaney as one of the winners of the American Psychological Association's Award for Distinguished Scientific Contributions (2012). Michael J. Meaney has taken the phenomenon of "handling" of newborn rats and opened a new area of investigation that has given new meaning to epigenetics via his work demonstrating transgenerational…

  2. Michael Young and the Curriculum Field in South Africa

    Science.gov (United States)

    Hoadley, Ursula

    2015-01-01

    The paper addresses the question of what we should make of Michael Young's recent work with respect to curriculum theory by considering the particular case of South African curriculum reform. The paper thus traces two trajectories: the evolution of Michael Young's ideas over time and South African curriculum reform in the post-apartheid period.…

  3. An Interview with Sir Michael Marmot

    Directory of Open Access Journals (Sweden)

    Editors

    2009-06-01

    Full Text Available In August of 2008 the WHO Commission on the Social Determinants of Health concluded its work with the publication of a report entitled: “Closing the gap in a generation: Health equity through action on the social determinants of health.” The Commission’s chair, Sir Michael Marmot, was kind enough to answer our questions about the Commission’s recommendations. This interview was conducted by email in May of this year. Social Medicine: We congratulate the Com-mission on its excellent work in bringing attention to the social determinants of health and the Commission’s call for health equity. We appreciated the Commission’s recognition that: “Social Justice is a matter of life and death.” We were also happy that the Commission included representatives of civil society in their work. This was an important affirmation of democratic values. When thinking about health inequalities people often use the analogue of the ladder to show how the gradient of worsening health outcomes affects all people in society except (presumably those at the very top. Thinking about the ladder leads us to pose the following question: Is making the ladder shorter (i.e. reducing inequalities the only approach to inequalities or is it possible to imagine making the ladder disappear entirely? Sir Michael Marmot: All societies have hier-archies. It is not conceivable, therefore, to have a society with no ladder. The conceptual framework of the Commission on Social Determinants of Health leads us to think of at least two (linked ways to address the relation between position on the ladder and health: act at the societal level to reduce social inequalities, and break the link between position in the social hierarchy and health. The first argues for reducing the slope of the social gradient. To see this, suppose, just for a moment, that the ladder were defined on the basis of years of education. People who had three years or fewer had life expectancy of 50 years

  4. Yo ban? Rape rap and limits of free speech in India : An argument analysis of the debate about banning the artist Honey Singh

    OpenAIRE

    Bergdahl, Becky

    2013-01-01

    This thesis consists of an argument analysis of three columns published in the Indian newspaper The Indian Express in the aftermath of the gangrape and murder of a young woman in Delhi in December 2012, and the following debate about glorification of rape in Indian popular culture. One of the columnists is arguing in favour of including gender as a category in the Indian law on hate speech, thereby banning an artist called Honey Singh and his lyrics about rape. The two other columnists are ar...

  5. Race, punishment, and the Michael Vick experience.

    Science.gov (United States)

    Piquero, Alex R; Piquero, Nicole Leeper; Gertz, Marc; Baker, Thomas; Batton, Jason; Barnes, J C

    2011-01-01

    Objective. The relationship between race and crime has been contentious, focusing primarily on offending and incarceration patterns among minorities. There has been some limited work on public perceptions of criminal punishment, and findings show that while minorities believe in the role and rule of law, they simultaneously perceive the justice system as acting in a biased and/or unfair manner. Two limitations have stalled this literature. First, research has focused mainly on criminal punishments to the neglect of noncriminal punishments. Second, most studies have not examined whether race remains salient after considering other demographic variables or discrimination and legitimacy attitudes.Methods. Using data from 400 adults, we examine how race affects perceptions of criminal punishment and subsequent reinstatement into the National Football League in the case of Michael Vick, a star professional quarterback who pled guilty to charges of operating an illegal dog-fighting ring.Results. Findings show that whites are more likely to view Vick's punishment as too soft and that he should not be reinstated, while nonwhites had the opposite views. Race remained significant after controlling for other variables believed to be related to punishment perceptions.Conclusion. Attitudes toward both criminal punishment and NFL reinstatement vary across race such that there exists important divides in how individuals perceive the system meting out punishment and subsequently reintegrating offenders back into society. These results underscore that white and nonwhites perceive the law and its administration differently.

  6. Obituary: Michael John Klein, 1940-2005

    Science.gov (United States)

    Gulkis, Samuel

    2006-12-01

    Michael John Klein died on 14 May 2005 at home in South Pasadena, California. The cause of death was tongue cancer that metastasized to the lungs. He was a non-smoker. Mike was a passionate radio astronomer, a trusted astronomical observer, an educator and a family man. Mike was born on 19 January 1940 in Ames, Iowa, the son of Florence Marie (Graf) and Fred Michael Klein. His mother was a homemaker, and his father was a banker. Mike had two older sisters, Lois Jean (Klein) Flauher and Marilyn June (Klein) Griffin. In 1962, Mike married his high school sweetheart Barbara Dahlberg, who survives him along with their three children, Kristin Marie (Klein) Shields, Michael John Klein Jr., Timothy Joel Klein, and six grandchildren. Mike developed a love for astronomy early in his life, and credited an early morning, newspaper-delivery route that he had at age twelve, which took him outside well before sunrise. He told family members that as he walked along his route, he stared into the sky and wondered what everything was. He studied sky charts, located stars, and began to understand how the planets shifted their positions relative to the stars each day. Another big influence in Mike's life was his brother in-law, Jim Griffin. Jim helped Mike understand that his passion for science did not have to remain a hobby, but could and should become a career. Jim's encouragement led Mike to attend Iowa State University in Ames, where he earned a BS in electrical engineering in 1962. Mike then started graduate school in electrical engineering at Michigan State, but after one semester transferred to the University of Michigan, Ann Arbor, where he earned an MS (1966) and PhD (1968) in astronomy. His doctoral dissertation, under the direction of Professor Fred Haddock, was based on extensive observations of the planets and examined the physical and thermal properties of planetary atmospheres and surfaces. Mike was awarded a Resident Research Associate position at JPL by the National

  7. Ethnomedicinal plants used to treat skin diseases by Tharu community of district Udham Singh Nagar, Uttarakhand, India.

    Science.gov (United States)

    Sharma, Jyotsana; Gairola, Sumeet; Sharma, Yash Pal; Gaur, R D

    2014-12-02

    Tharu community is the largest primitive indigenous community of the Uttarakhand, India. In this article we have scientifically enumerated medicinal plants and herbal preparations used by the Tharu community to treat various skin diseases, and discussed dermatological properties of these plants in the light of previous ethnomedicinal, microbiological, pharmacological, toxicological, phytochemical and clinical studies. Ethnomedicinal survey was conducted in different villages of Tharu community located in district Udham Singh Nagar, Uttarakhand, India. Ethnomedicinal information on plants used to treat various skin diseases was collected from 122 individuals (93 males and 29 females), including 35 experienced herbal practitioners and 87 local villagers. For each of the recorded plant species the use value (UV) and fidelity level (FL) was calculated. The informant consensus factor (Fic) was also calculated to find out the homogeneity in the information given by the informants. A total of 90 plant species belonging to 86 genera and 48 families were used by the Tharu community to treat various skin diseases viz., wounds (38 spp.), boils (32 spp.), cuts (18 spp.), leprosy (11 spp.), eczema (10 spp.), itching (7 spp.), ringworm (5 spp.), burns (4 spp.), leucoderma (4 spp.), cracked heels (2 spp.), dandruff (3 spp.), body infection (2 spp.), chilblains (2 spp.), hair fall (2 spp.) and toes infection (2 spp.). Information on botanical name, family, vernacular name, ailments treated, mode and dose of herbal preparations, UV and FL values are provided for each of the recorded species. According to UV value most preferred plant species used to treat skin diseases by Tharu community was Ricinus communis L. followed by Tridax procumbens (L.) L., Azadirachta indica A. Juss., Ageratum conyzoides and Allium cepa L. The present study has revealed significant information on various medicinal plants used to treat skin diseases by Tharu community. Literature review has confirmed most

  8. Meet EPA Scientist Michael Nye, Ph.D.

    Science.gov (United States)

    Michael Nye, Ph.D., is a social scientist who studies natural risk, socio-demographic change and sustainable behavior. Prior to joining EPA, he worked for the UK Environment Agency in flood risk management and emergency preparedness

  9. Nitrosonium (NO+) catalyzed Michael addition of indoles to unsaturated enones

    Institute of Scientific and Technical Information of China (English)

    Guai Li Wu; Long Min Wu

    2008-01-01

    An efficient Michael addition of indoles to unsaturated enones, such as chalcones and β-nitrostyrenes, was achieved in thepresence of a catalytic amount of nitrosoninm tetrafluoroborate in ethyl ether.

  10. Immigration and Social Systems : Collected Essays of Michael Bommes

    NARCIS (Netherlands)

    2012-01-01

    Michael Bommes (hoogleraar Sociologie en Migratieonderzoek) was een van de meest briljante en originele geleerden in zijn vakgebied. Deze postume bundel bevat een selectie van zijn belangrijkste werk over immigratie en de verzorgingsstaat, de integratie van immigranten, discriminatie, illegale

  11. Michael Polanyi: Science as Personal Knowledge and Social Practice.

    Science.gov (United States)

    Nye, Mary Jo

    2017-03-20

    Tacit knowing: 2016 marked the 125th anniversary of the birth of the physical chemist Michael Polanyi, as well as the 40th of his death. This essay discusses his philosophy of science-in particular, his most significant work in this area, Personal Knowledge-from the perspective of his personal biography, as well as its lasting influence on the social sciences. In the photograph: Michael Polanyi at the Fritz Haber Institute in 1968.

  12. Principles of Chemistry (by Michael Munowitz)

    Science.gov (United States)

    Kovac, Reviewed By Jeffrey

    2000-05-01

    At a time when almost all general chemistry textbooks seem to have become commodities designed by marketing departments to offend no one, it is refreshing to find a book with a unique perspective. Michael Munowitz has written what I can only describe as a delightful chemistry book, full of conceptual insight, that uses a novel and interesting pedagogic strategy. This is a book that has much to recommend it. This is the best-written general chemistry book I have ever read. An editor with whom I have worked recently remarked that he felt his job was to help authors make their writing sing. Well, the writing in Principles of Chemistry sings with the full, rich harmonies and creative inventiveness of the King's Singers or Chanticleer. Here is the first sentence of the introduction: "Central to any understanding of the physical world is one discovery of paramount importance, a truth disarmingly simple yet profound in its implications: matter is not continuous." This is prose to be savored and celebrated. Principles of Chemistry has a distinct perspective on chemistry: the perspective of the physical chemist. The focus is on simplicity, what is common about molecules and reactions; begin with the microscopic and build bridges to the macroscopic. The author's perspective is clear from the organization of the book. After three rather broad introductory chapters, there are four chapters that develop the quantum mechanical theory of atoms and molecules, including a strong treatment of molecular orbital theory. Unlike many books, Principles of Chemistry presents the molecular orbital approach first and introduces valence bond theory later only as an approximation for dealing with more complicated molecules. The usual chapters on descriptive inorganic chemistry are absent (though there is an excellent chapter on organic and biological molecules and reactions as well as one on transition metal complexes). Instead, descriptive chemistry is integrated into the development of

  13. Entrevista al profesor D. Michael Walker. - Interview with Professor D. Michael Walker.

    Directory of Open Access Journals (Sweden)

    Caravaca Guerrero, Consuelo Isabel

    2014-12-01

    Full Text Available Entrevistar a un investigador de la talla de D. Michael Walker supone hablar de un investigador reconocido a nivel nacional e internacional, uno de los mayores expertos en evolución humana de nuestros días. Nació en Colchester (Inglaterra en 1941 y tiene doble nacionalidad: británica y australiana. Actualmente es profesor emérito de la Universidad de Murcia en el Departamento de Zoología y Antropología Física de la Facultad de Biología. Pero su currículum no acaba aquí, Michael realizó tres carreras, Fisiología Animal, Medicina, y Arqueología Prehistórica, en la Universidad de Oxford. Es Doctor por esta universidad, gracias a su tesis leída sobre Paleoantropología y Prehistoria de las cuencas de los ríos Segura y Vinalopó. Nuestro entrevistado, también fue elegido Académico (Fellow –F.S.A.- en 1988 de la Society of Antiquaries of Londono SAL. Fundada en 1707, la SAL es la equivalente británica de la española Real Academia de la Historia. Es Fellow también del Real Instituto Antropológico de la Gran Bretaña (Royal Anthropological Institute of Great Britain y socio emérito de la Asociación Americana de Antropólogos Físicos (American Association of Physical Anthropologists.

  14. Guest Foreword from Michael Thomas CMG QC

    Directory of Open Access Journals (Sweden)

    Michael Thomas

    2012-04-01

    precedents and thought in a unique legal market in which ideas drawn from Islamic law, civil law and common law can intermingle and blend. It is not surprising therefore to see that this new publication will be dedicated to the subject of international law, both public and private. Its laudable aim is to promote legal discourse around the world, and to promote a wider international understanding of contemporary legal issues for the common benefit. As an open access, bilingual journal, addressing topics concerning any jurisdiction, I hope it will reach a wide audience, and fulfil its aim of promoting understanding between different cultures. I am sure that the journal will not only benefit Qatar’s legal community by advancing academic and practice-based legal discussion. I am also confident that it will stimulate thought in the global legal community at large. May I wish it every success and a long life. Michael Thomas CMG QC

  15. Obituary: Michael John Seaton, 1923-2007

    Science.gov (United States)

    Pradhan, Anil; Nahar, Sultana

    2007-12-01

    Professor Michael John Seaton, hailed as the "Father of Atomic Astrophysics," passed away on May 29, 2007. He was one of the few Honorary Fellows of both the American Astronomical Society and the American Physical Society, so honored for his monumental contributions to both physics and astronomy. Mike Seaton was born on January 16, 1923 in Bristol, England. He attended Wallington County High School. But his leftist political activities, even at that stage, led to his expulsion, though he was eventually allowed to matriculate. He enlisted in the Royal Air Force as a navigator during the Second World War, and flew many dangerous missions. His legendary concentration and precision are reflected in the following anecdote. Once after a bombing mission his aircraft was lost in fog over the Alps. Seaton calculated the position and coordinates in flight to guide the aircraft. When the fog lifted, the crew found themselves flying perilously close to the mountains, but made it safely back. His associates often said, "A Seaton calculation is carried out as if his life depended on it." After the War he was admitted to University College London (UCL) as an undergraduate. Thereafter, he spent all of his professional career at UCL. Seaton received his Batchelor's degree in 1948, and his Ph.D. in 1951. His tenure at UCL coincided with the golden age of atomic astrophysics, for he was largely responsible for it. Seaton was elected Fellow of the Royal Society in 1967, and as President of the Royal Astronomical Society (RAS) in 1978. He was the recipient of an Honorary Doctorate from the Observatoire de Paris, an Honorary D.Sc. from the Queen's University of Belfast, the Gold Medal for Astronomy by the RAS, the Guthrie Medal by the Institute of Physics, the Royal Society Hughes award for lifetime work by the RAS, and several other prestigious awards. Nevertheless, as Alex Dalgarno recently remarked, Seaton was not part of the establishment because he chose not to be. Though rooted in

  16. Triphenylphosphine-Catalyzed Michael Addition of Alcohols to Acrylic Compounds

    Institute of Scientific and Technical Information of China (English)

    LIU, Hai-Ling; JIANG, Huan-Feng; WANG, Yu-Gang

    2007-01-01

    A facile triphenylphosphine-catalyzed Michael addition of alcohols to acrylic compounds was described. The reaction was carried out in open air at refluxing temperature in the presence of 10 mol% PPh3. Michael addition of saturated and unsaturated alcohols to acrylonitrile or acrylates has been examined. The reaction gaveβ-alkoxy derivatives with isolated yields of 5%-79%. PPh3 is cheaper and more stable than those trialkylphosphines previously used for the similar reactions, and the products can be easily separated from the reaction mixture via distillation.

  17. Comments on ‘A comparative study of ANN and neuro-fuzzy for the prediction of dynamic constant of rockmass’ by T N Singh, R Kanchan, A K Verma and K Saigal

    Indian Academy of Sciences (India)

    Tarkan Erdik; Zekai Şen

    2008-12-01

    Singh et al (2005)examined the potential of the ANN and neuro-fuzzy systems application for the prediction of dynamic constant of rockmass. However,the model proposed by them has some drawbacks according to fuzzy logic principles.This discussion will focus on the main fuzzy logic principles which authors and potential readers should take into consideration.

  18. Lipase-Catalyzed Aza-Michael Reaction on Acrylate Derivatives

    NARCIS (Netherlands)

    Steunenberg, P.; Sijm, M.; Zuilhof, H.; Sanders, J.P.M.; Scott, E.L.; Franssen, M.C.R.

    2013-01-01

    A methodology has been developed for an efficient and selective lipase-catalyzed aza-Michael reaction of various amines (primary and secondary) with a series of acrylates and alkylacrylates. Reaction parameters were tuned, and under the optimal conditions it was found that Pseudomonas stutzeri lipas

  19. Michael hydratase alcohol dehydrogenase or just alcohol dehydrogenase?

    NARCIS (Netherlands)

    Resch, V.A.; Jin, J.; Chen, B.S.; Hanefeld, U.

    2014-01-01

    The Michael hydratase – alcohol dehydrogenase (MhyADH) from Alicycliphilus denitrificans was previously identified as a bi-functional enzyme performing a hydration of α,β-unsaturated ketones and subsequent oxidation of the formed alcohols. The investigations of the bi-functionality were based on a

  20. Michael Moore kaevati kohtusse pettuse eest / Mari Rebane

    Index Scriptorium Estoniae

    Rebane, Mari

    2006-01-01

    Dokumentaalfilm "9/11 Fahrenheiti" ("Fahrenheit 9/11") : režissöör Michael Moore : USA 2004. Iraagi sõja invaliidistunud veteran andis režissööri kohtusse teda kujutavate flmikaadrite loata ja tenentsliku kasutamise pärast

  1. Reading Michael Apple--The Sociological Imagination at Work

    Science.gov (United States)

    Ball, Stephen J.

    2007-01-01

    This article discusses Michael Apple's contribution to the sociology of education and education policy analysis and the politics of education. It focuses on ways of "reading" Apple as an intellectual and an activist and looks at the trajectory of his work over a long and illustrious career.

  2. Eesti luksushotellide ristiisa / Michael Stenner ; interv. Malle Koido

    Index Scriptorium Estoniae

    Stenner, Michael

    2007-01-01

    Eesti tipphotelle 1997. aastast juhtinud sakslane, praegu hotellide Kolm Õde ja Telegraaf juht räägib Eesti ja Saksamaa erinevustest, Eesti hotelliärist, teeninduskultuurist ja personalist. Lisa: Kes on Michael Stenner ning kuidas ta Eestisse sattus? Ilmunud ka: Linnaleht : Pärnu, 23. veebr. 2007, lk. 5-6

  3. Tweeting Prayers and Communicating Grief over Michael Jackson Online

    Science.gov (United States)

    Sanderson, Jimmy; Cheong, Pauline Hope

    2010-01-01

    Death and bereavement are human experiences that new media helps facilitate alongside creating new social grief practices that occur online. This study investigated how people's postings and tweets facilitated the communication of grief after pop music icon Michael Jackson died. Drawing on past grief research, religion, and new media studies, a…

  4. Genres and Genre Theory: A Response to Michael Rosen

    Science.gov (United States)

    Christie, Frances

    2013-01-01

    This paper responds to Michael Rosen's blog entries, "How Genre Theory Saved the World", arguing that genre theory in the tradition of systemic functional linguistics (SFL) has made an important contribution to language and literacy pedagogy. It emerged in the Australian context in about 1980 and was initially developed in response to…

  5. Michael Moore kaevati kohtusse pettuse eest / Mari Rebane

    Index Scriptorium Estoniae

    Rebane, Mari

    2006-01-01

    Dokumentaalfilm "9/11 Fahrenheiti" ("Fahrenheit 9/11") : režissöör Michael Moore : USA 2004. Iraagi sõja invaliidistunud veteran andis režissööri kohtusse teda kujutavate flmikaadrite loata ja tenentsliku kasutamise pärast

  6. Solvent-free microwave-mediated Michael addition reactions

    Indian Academy of Sciences (India)

    H Surya Prakash Rao; S Jothilingam

    2005-07-01

    Facile Michael addition of active methylene compounds to ,-unsaturated carbonyl compounds takes place on the surface of potassium carbonate under microwave irradiation. Further studies on microwave-mediated Robinson annulations reveal a convenient and facile method for condensation of chalcone with methylene compounds to furnish cyclohexenones.

  7. SuchThatCast Episode 6: Michael Boylan

    NARCIS (Netherlands)

    Soraker, Johnny

    2012-01-01

    Michael Boylan is the John J. McDonnell jr chair in Ethics, and professor and chair of the philosophy department at Marymount University in Arlington, Virginia. In addition to being a poet and novelist, he has written more than 100 published articles and 25 books primarily in ethics, social and

  8. The correspondence of Michael Faraday, v.4 1849-1855

    CERN Document Server

    James, F

    2008-01-01

    This volume includes 70% of previously unpublished letters of Michael Farday spanning half of the 1850s and most of 1860. Topics include Faraday's work on regelation, the transmission of light through gold and his appointment by Emperor Napoleon III to be a Commander of the Legion of Honour.

  9. Correspondence of Michael Faraday, v.5 1855-1860

    CERN Document Server

    Faraday, Michael

    2008-01-01

    This volume includes 70% of previously unpublished letters of Michael Farday spanning half of the 1850s and most of 1860. Topics include Faraday's work on regelation, the transmission of light through gold and his appointment by Emperor Napoleon III to be a Commander of the Legion of Honour.

  10. Aza-Michael Reaction for an Undergraduate Organic Chemistry Laboratory

    Science.gov (United States)

    Nigam, Manisha; Rush, Brittney; Patel, Jay; Castillo, Raul; Dhar, Preeti

    2016-01-01

    A green, aza-Michael reaction is described that can be used to teach undergraduate students conjugate addition of nitrogen nucleophile to an a,ß-unsaturated ester. Students analyze spectral data of the product obtained from the assigned reaction to determine product structure and propose the mechanism of its formation. The experiment requires…

  11. Professor Porter ja tema viis konkurentsitegurit / Michael E Porter

    Index Scriptorium Estoniae

    Porter, Michael E

    2008-01-01

    Maailmas tuntud juhtimisguru Michael Porter viie konkurentsijõu teooriast ja selle rakendatavusest erinevates valdkondades. Lisad: Erinevused valdkondade kasumlikkuses; 5 määravat konkurentsijõudu; Investeeritud kapitali keskmine tasuvus; Mõnede USA tegevusvaldkondade kasumlikkus; Valdkonnaanalüüs praktikas; Valdkonna määratlemine; Valdkonnaanalüüsi sammud

  12. Michael Young's "The Rise of the Meritocracy": A Philosophical Critique

    Science.gov (United States)

    Allen, Ansgar

    2011-01-01

    This paper examines Michael Young's 1958 dystopia, "The Rise of the Meritocracy". In this book, the word "meritocracy" was coined and used in a pejorative sense. Today, however, meritocracy represents a positive ideal against which we measure the justice of our institutions. This paper argues that, when read in the twenty-first century, Young's…

  13. Aza-Michael Reaction for an Undergraduate Organic Chemistry Laboratory

    Science.gov (United States)

    Nigam, Manisha; Rush, Brittney; Patel, Jay; Castillo, Raul; Dhar, Preeti

    2016-01-01

    A green, aza-Michael reaction is described that can be used to teach undergraduate students conjugate addition of nitrogen nucleophile to an a,ß-unsaturated ester. Students analyze spectral data of the product obtained from the assigned reaction to determine product structure and propose the mechanism of its formation. The experiment requires…

  14. Educational Implications of Michael Fishbane's "Sacred Attunement: A Jewish Theology"

    Science.gov (United States)

    Marom, Daniel

    2008-01-01

    This article posits Michael Fishbane's Judaic scholarship as a prime resource for Jewish education. The link between the two fields can be made through a translation of the theological underpinnings of Fishbane's insights into Judaism to educational purposes and practices. Initial work with Jewish educators on establishing this link encouraged…

  15. An active and selective heterogeneous catalytic system for Michael addition

    Institute of Scientific and Technical Information of China (English)

    Hoda Keipour; Mohammad A. Khalilzadeh; Abolfazl Hosseini; Afsaneh Pilevar; Daryoush Zareyee

    2012-01-01

    Potassium fluoride doped natural zeolite was found to be an efficient and selective solid base catalyst for 1,4-Michael addition.The catalyst is easily prepared and the workup procedure simplified by simple filtration.All products were obtained in high yields as well as short reaction times.

  16. Fooling LC: Michael Crichton and "Eaters of the Dead."

    Science.gov (United States)

    Lonergan, David

    1998-01-01

    Chronicles the variety of means with which the novelist Michael Crichton has attempted to give his works the appearance of nonfiction. Specific and successful techniques utilized in "Eaters of the Dead" are noted, and the resulting erroneous classifications by the Library of Congress and subsequent catalogers are discussed. (Author)

  17. Berliinis võidutses Michael Haneke / Jüri Laulik

    Index Scriptorium Estoniae

    Laulik, Jüri, 1959-

    2005-01-01

    IX PÖFFil linastuv Michael Haneke film "Varjatud" ("Cache") võitis laupäeval mitu Euroopa Filmiakadeemia auhinda, sealhulgas parima filmi, parima lavastaja ja parima meesnäitleja (Daniel Auteuil) auhinna. Parima naisnäitleja tiitli pälvis Julia Jentsch ("Sophie Scholli viimased päevad"). Elutööpreemia sai sir Sean Connery

  18. "No More Excuses": Michael M. Crow on Analytics

    Science.gov (United States)

    Crow, Michael M.

    2012-01-01

    Michael M. Crow became the 16th president of Arizona State University in July 2002, with the goal of transforming ASU into what he calls a "New American University"--an institution combining the highest levels of academic excellence, inclusiveness to a broad demographic, and maximum societal impact. His view included increasing graduate…

  19. A Good Time: A Conversation with C. Michael Nelson

    Science.gov (United States)

    Zabel, Robert; Kaff, Marilyn; Teagarden, Jim

    2015-01-01

    C. Michael Nelson began his special education career as a teacher of adolescents with learning and behavior disorders. He has worked as a child psychologist and as a professor with the Department of Special Education and Rehabilitation Counseling at the University of Kentucky. He coordinated the graduate Personnel Preparation Program for Teachers…

  20. Michael hydratase alcohol dehydrogenase or just alcohol dehydrogenase?

    NARCIS (Netherlands)

    Resch, V.A.; Jin, J.; Chen, B.S.; Hanefeld, U.

    2014-01-01

    The Michael hydratase – alcohol dehydrogenase (MhyADH) from Alicycliphilus denitrificans was previously identified as a bi-functional enzyme performing a hydration of α,β-unsaturated ketones and subsequent oxidation of the formed alcohols. The investigations of the bi-functionality were based on a s

  1. SuchThatCast Episode 6: Michael Boylan

    NARCIS (Netherlands)

    Søraker, J.H.

    2012-01-01

    Michael Boylan is the John J. McDonnell jr chair in Ethics, and professor and chair of the philosophy department at Marymount University in Arlington, Virginia. In addition to being a poet and novelist, he has written more than 100 published articles and 25 books primarily in ethics, social and poli

  2. Insight into the Mechanism of the Michael Reaction.

    Science.gov (United States)

    Giraldo, Carolina; Gómez, Sara; Weinhold, Frank; Restrepo, Albeiro

    2016-07-01

    The mechanism for the nucleophilic addition step of the Michael reaction between methanethiol as a model Michael donor and several α-substituted methyl acrylates (X=F, Cl, Me, H, CN, NO2 ) as model Michael acceptors is described in detail. We suggest a novel way to condense electrophilic Fukui functions at specific atoms in terms of the contributions from the atomic orbitals to the LUMO or, more generally, to the orbital controlling the reaction. This procedure correctly associates activation energies to local electrophilic Fukui indices for the cases treated in this work. The calculated reaction barriers strongly depend on the nature of the substituent. As a general rule, activation energies are governed by structural changes, although electronic factors are significant for electron-withdrawing groups. Nucleophilic addition to Michael receptors is best described as a highly nonsynchronous process, in which the geometry of the transition state comprises a nonplanar six-membered ring. Formation of the S⋅⋅⋅C bond, which defines the interaction between the reactants, progresses ahead of all other primitive processes in the early stages of the transformation. In view of our results, we postulate that highly complex chemical reactions, as is the case for the nucleophilic addition step studied herein, that involve cleavage/formation of a total of six bonds, lower their activation energies by favoring nonsynchronicity, that is, for these types of systems, primitive changes should advance at different rates.

  3. Professor Porter ja tema viis konkurentsitegurit / Michael E Porter

    Index Scriptorium Estoniae

    Porter, Michael E

    2008-01-01

    Maailmas tuntud juhtimisguru Michael Porter viie konkurentsijõu teooriast ja selle rakendatavusest erinevates valdkondades. Lisad: Erinevused valdkondade kasumlikkuses; 5 määravat konkurentsijõudu; Investeeritud kapitali keskmine tasuvus; Mõnede USA tegevusvaldkondade kasumlikkus; Valdkonnaanalüüs praktikas; Valdkonna määratlemine; Valdkonnaanalüüsi sammud

  4. Tweeting Prayers and Communicating Grief over Michael Jackson Online

    Science.gov (United States)

    Sanderson, Jimmy; Cheong, Pauline Hope

    2010-01-01

    Death and bereavement are human experiences that new media helps facilitate alongside creating new social grief practices that occur online. This study investigated how people's postings and tweets facilitated the communication of grief after pop music icon Michael Jackson died. Drawing on past grief research, religion, and new media studies, a…

  5. Immigration and Social Systems : Collected Essays of Michael Bommes

    OpenAIRE

    2012-01-01

    Popular science Michael Bommes (hoogleraar Sociologie en Migratieonderzoek) was een van de meest briljante en originele geleerden in zijn vakgebied. Deze postume bundel bevat een selectie van zijn belangrijkste werk over immigratie en de verzorgingsstaat, de integratie van immigranten, discriminatie, illegale migratie, migrantennetwerken en migratiebeleidsonderzoek. Deze bundel laat zien hoe Bommes' inzichten en deskundigheid een fundamentele bijdrage hebben geleverd aan immigratiestudies....

  6. A novel integrase-containing element may interact with Laem-Singh virus (LSNV) to cause slow growth in giant tiger shrimp

    Science.gov (United States)

    2011-01-01

    Background From 2001-2003 monodon slow growth syndrome (MSGS) caused severe economic losses for Thai shrimp farmers who cultivated the native, giant tiger shrimp, and this led them to adopt exotic stocks of the domesticated whiteleg shrimp as the species of cultivation choice, despite the higher value of giant tiger shrimp. In 2008, newly discovered Laem-Singh virus (LSNV) was proposed as a necessary but insufficient cause of MSGS, and this stimulated the search for the additional component cause(s) of MSGS in the hope that discovery would lead to preventative measures that could revive cultivation of the higher value native shrimp species. Results Using a universal shotgun cloning protocol, a novel RNA, integrase-containing element (ICE) was found in giant tiger shrimp from MSGS ponds (GenBank accession number FJ498866). In situ hybridization probes and RT-PCR tests revealed that ICE and Laem-Singh virus (LSNV) occurred together in lymphoid organs (LO) of shrimp from MSGS ponds but not in shrimp from normal ponds. Tissue homogenates of shrimp from MSGS ponds yielded a fraction that gave positive RT-PCR reactions for both ICE and LSNV and showed viral-like particles by transmission electron microscopy (TEM). Bioassays of this fraction with juvenile giant tiger shrimp resulted in retarded growth with gross signs of MSGS, and in situ hybridization assays revealed ICE and LSNV together in LO, eyes and gills. Viral-like particles similar to those seen in tissue extracts from natural infections were also seen by TEM. Conclusions ICE and LSNV were found together only in shrimp from MSGS ponds and only in shrimp showing gross signs of MSGS after injection with a preparation containing ICE and LSNV. ICE was never found in the absence of LSNV although LSNV was sometimes found in normal shrimp in the absence of ICE. The results suggest that ICE and LSNV may act together as component causes of MSGS, but this cannot be proven conclusively without single and combined bioassays

  7. A novel integrase-containing element may interact with Laem-Singh virus (LSNV to cause slow growth in giant tiger shrimp

    Directory of Open Access Journals (Sweden)

    Sriurairatana Siriporn

    2011-05-01

    Full Text Available Abstract Background From 2001-2003 monodon slow growth syndrome (MSGS caused severe economic losses for Thai shrimp farmers who cultivated the native, giant tiger shrimp, and this led them to adopt exotic stocks of the domesticated whiteleg shrimp as the species of cultivation choice, despite the higher value of giant tiger shrimp. In 2008, newly discovered Laem-Singh virus (LSNV was proposed as a necessary but insufficient cause of MSGS, and this stimulated the search for the additional component cause(s of MSGS in the hope that discovery would lead to preventative measures that could revive cultivation of the higher value native shrimp species. Results Using a universal shotgun cloning protocol, a novel RNA, integrase-containing element (ICE was found in giant tiger shrimp from MSGS ponds (GenBank accession number FJ498866. In situ hybridization probes and RT-PCR tests revealed that ICE and Laem-Singh virus (LSNV occurred together in lymphoid organs (LO of shrimp from MSGS ponds but not in shrimp from normal ponds. Tissue homogenates of shrimp from MSGS ponds yielded a fraction that gave positive RT-PCR reactions for both ICE and LSNV and showed viral-like particles by transmission electron microscopy (TEM. Bioassays of this fraction with juvenile giant tiger shrimp resulted in retarded growth with gross signs of MSGS, and in situ hybridization assays revealed ICE and LSNV together in LO, eyes and gills. Viral-like particles similar to those seen in tissue extracts from natural infections were also seen by TEM. Conclusions ICE and LSNV were found together only in shrimp from MSGS ponds and only in shrimp showing gross signs of MSGS after injection with a preparation containing ICE and LSNV. ICE was never found in the absence of LSNV although LSNV was sometimes found in normal shrimp in the absence of ICE. The results suggest that ICE and LSNV may act together as component causes of MSGS, but this cannot be proven conclusively without single

  8. Domino Michael-Michael and Aldol-Aldol Reactions: Diastereoselective Synthesis of Functionalized Cyclohexanone Derivatives Containing Quaternary Carbon Center.

    Science.gov (United States)

    Ghorai, Manas K; Halder, Sandipan; Das, Subhomoy

    2015-10-02

    A simple strategy for the synthesis of highly functionalized cyclohexanone derivatives containing an all-carbon quaternary center from α-(aryl/alkyl)methylidene-β-keto esters or β-diketones via a K-enolate mediated domino Michael-Michael reaction sequence with moderate to good yield and excellent diastereoselectivity (de > 99%) is described. Interestingly, Li-base mediated reaction of α-arylmethylidene-β-diketones affords functionalized 3,5-dihydroxy cyclohexane derivatives as the kinetically controlled products via a domino aldol-aldol reaction sequence with excellent diastereoselectivity. Li-enolates of the β-keto esters or β-diketones undergo facile domino Michael-Michael reaction with nitro-olefins to afford the corresponding nitrocyclohexane derivatives in good yields and excellent diastereoselectivity (de > 99%). The formation of the products and the observed stereoselectivity were explained by plausible mechanisms and supported by extensive computational study. An asymmetric version of the protocol was explored with (L)-menthol derived nonracemic substrates, and the corresponding nonracemic cyclohexanone derivatives containing an all-carbon quaternary center were obtained with excellent stereoselectivity (de, ee > 99%).

  9. Michael Pärt ئ suure muusika taustajõud / Michael Pärt ; interv. Siim Nestor

    Index Scriptorium Estoniae

    Pärt, Michael

    2008-01-01

    Arvo Pärdi pojast Michael Pärdist. Tema tööst "music editor"-ina - helimonteerijana, tööst muusika produktsiooni, salvestamise ja muusika kirjutamise abijõuna. Koostööst maailmas tuntud muusikutega

  10. Michael Pärt ئ suure muusika taustajõud / Michael Pärt ; interv. Siim Nestor

    Index Scriptorium Estoniae

    Pärt, Michael

    2008-01-01

    Arvo Pärdi pojast Michael Pärdist. Tema tööst "music editor"-ina - helimonteerijana, tööst muusika produktsiooni, salvestamise ja muusika kirjutamise abijõuna. Koostööst maailmas tuntud muusikutega

  11. Aza-Michael Addition of Isatin and Phthalimide to Symmetrical Fumaric Esters in Ionic Liquid Media

    Institute of Scientific and Technical Information of China (English)

    IMANZADEH Gholam Hassan; MOLLAEI TAVANA Mahdieh; ZAMANLOO Mohammad Reza; MANSOORI Yagoub

    2009-01-01

    Highly efficient aza-Michael additions of isatin and phthalimide to symmetrical fumaric esters in ionic liquid media to produce the corresponding Michael adducts in excellent yields are described which were performed at 100 ℃ for 1-5 h. The results show that these aza-Michael additions are not effective with fumaric esters containing sterically hindered alkoxy groups.

  12. Tribute to Professor Anthony J. McMichael

    Directory of Open Access Journals (Sweden)

    Ashwin Swaminathan

    2014-11-01

    Full Text Available Emeritus Professor A. J. “Tony” McMichael (1942–2014 was an internationally renowned and pioneering Australian academic and advocate in epidemiology, who was passionate about understanding the influences of the environment on human health. In an illustrious career spanning more than four decades, he made significant contributions to the scientific community and policy discourse—including ground-breaking research related to the health of children. McMichael was a prolific academic writer with over 300 peer-reviewed papers; 160 book chapters and two sole-authored books. However, his outstanding talent was for integrating complex and seemingly unrelated strands from the environmental and health sciences into a cohesive narrative—and highlighting its relevance to lay persons, scientists and governments alike. He was instrumental in validating this nascent field of research and inspiring many others to follow his lead.

  13. Double Michael Addition Reaction of Bischalcone under Ultrasound

    Institute of Scientific and Technical Information of China (English)

    LI,Ji-Tai; XU,Wen-Zhi; CHEN,Guo-Feng; LI,Tong-Shuang

    2004-01-01

    @@ The Michael addition of 1,5-diaryl-1,4-pentadien-3-ones with active methylene compounds has been the subjects of many investigations. Ultrasound has increasingly been used in organic synthesis in the last three decades. Compared with traditional methods, this method is more convenient and easily controlled. A large number of organic reactions can be carried out in higher yield, shorter reaction time or milder conditions under ultrasonic irradiation. KF/Al2O3 as a useful solid supported catalyst has received considerable attention because of their high level of chemoselectivity and environmental compatibility as well as simplicity of operation and their ready availability at low cost. Herein we report the double Michael addition of dibenzalacetone with active methlene compounds such as dimethyl malonate, diethyl malonate,methyl cyanoacetate and ethyl cyanoacetate catalyzed by KF/Al2O3 under ultrasound irradiation.

  14. Tribute to Professor Anthony J. McMichael.

    Science.gov (United States)

    Swaminathan, Ashwin; Lucas, Robyn M; Harley, David

    2014-11-26

    Emeritus Professor A. J. "Tony" McMichael (1942-2014) was an internationally renowned and pioneering Australian academic and advocate in epidemiology, who was passionate about understanding the influences of the environment on human health. In an illustrious career spanning more than four decades, he made significant contributions to the scientific community and policy discourse-including ground-breaking research related to the health of children. McMichael was a prolific academic writer with over 300 peer-reviewed papers; 160 book chapters and two sole-authored books. However, his outstanding talent was for integrating complex and seemingly unrelated strands from the environmental and health sciences into a cohesive narrative-and highlighting its relevance to lay persons, scientists and governments alike. He was instrumental in validating this nascent field of research and inspiring many others to follow his lead.

  15. Pengaruh Tipografi pada Era Massimo Vignelli terhadap Tipografi Michael Bierut

    Directory of Open Access Journals (Sweden)

    Irwan Harnoko

    2011-09-01

    Full Text Available Massimo Vignelli is a senior graphic designer lived in New York, as a vocal modernism against postmodernism. His statement firmly opposing post-modernism in several occasions: interview in Helvetica the movie, type radio, talk show, and some articles in Looking Closer or AIGA Journal. Graphic design works of Massimo Vignelli reflected his characteristic, which is firmly choosing typeface. Typefaces of Vignelly are around 5 typefaces: Bodoni, Helvetica, Times Roman, Century, and Futura. The article uses formal analysis method. The writers collected materials about Michael Bierut, Massimo VIgnelli and Tibor Kalman from books and websites. The writers compare the typeface opinion of Massimo Vignelli (modernism designer, Michael Bierut designer (transition era designer from modernism to post-modernism, and Tibor Kalman (a designer in A Century of Graphic Design, as the influence of Bieruts betrayal over Vignelli.

  16. Pengaruh Tipografi pada Era Massimo Vignelli terhadap Tipografi Michael Bierut

    Directory of Open Access Journals (Sweden)

    Irwan Harnoko

    2011-10-01

    Full Text Available Massimo Vignelli is a senior graphic designer lived in New York, as a vocal modernism against post-modernism. His statement firmly opposing post-modernism in several occasions: interview in Helvetica the movie, typeradio, talkshow, and some articles in Looking Closer or AIGA Journal. Graphic design works of Massimo Vignelli reflected his characteristic, which is firmly choosing typeface. Typefaces of Vignelly are around 5 typefaces: Bodoni, Helvetica, Times Roman, Century, and Futura. The article uses formal analysis method. The writers collected materials about Michael Bierut, Massimo VIgnelli and Tibor Kalman from books and websites. The writers compare the typeface opinion of Massimo Vignelli (modernism designer, Michael Bierut designer (transition era designer from modernism to post-modernism, and Tibor Kalman (a designer in A Century of Graphic Design, as the influencer of Bierut’s betrayal over Vignelli. 

  17. Euroopa parimaks filmiks sai Michael Haneke "Valge lint" / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2009-01-01

    Euroopa Filmiakadeemia auhindadest: parima filmiauhinna sai Saksamaal Bochumis toimunud tseremoonial Michael Haneke "Valge lint", mille eest Haneke sai ka parima režissööri ja stsenaristi auhinna. Parimaks meesnäitlejaks pärjati Tahar Rahim ("Un Prophete"), parimaks naisnäitlejaks Kate Winslet ("The Reader"), publikupreemia sai Danny Boyle'i "Rentslimiljonär. Ka teistest võitjatest

  18. The cinema of Michael Bay : an aesthetic of excess

    OpenAIRE

    Bennett, Bruce

    2015-01-01

    The hyper-kinetic action films of Michael Bay have come to exemplify the commercial, technical and aesthetic transformations of contemporary blockbuster cinema during a period in which the dynamic, disorienting effects of media convergence are reconfiguring viewing practices and remodelling cinematic institutions. However, despite their commercial success and cultural visibility, these films remain more or less absent from academic criticism of late twentieth and early twenty-first century gl...

  19. Analysis of the black crust on Saint Michael's Church

    Science.gov (United States)

    Popister, I.; Zeman, A.

    2012-04-01

    The goal of the present study is to characterize the black crust on the main stone used at Saint Michael's Church in Cluj-Napoca, Romania. The gases in the atmosphere, along with natural and artificial pollutants can cause damage the integrity of the stone when it comes in contact with the stone's chemistry. In order to explain the mechanism of stone decay due to black crust it is necessary to know what "weathering" means, so it must be seen as a complex process that consists of: type of material, the environment in which the material is located, and the amount of time required for the process to take place. Each material has particular properties, due to its composition and genesis. When it comes in contact with the acidity of the "acid rain" (caused by sulphur, nitrogen oxides and carbon dioxide), the rain penetrates into the pore structure, corroding it and "allowing" the atmospheric particles to penetrate the stone. St. Michael's Church is one of the oldest Gothic architectural monuments in Cluj, Romania, being built predominantly from Cenozoic (Upper Eocene) limestone, locally known as the Cluj Limestone. The main quarry was in Baciu, near Cluj. The samples that were collected from the Saint Michael's Church were characterized by means of: optical microscope, Scattering Electronic Microscope, thin sections, EDS The samples that were collected from the Saint Michael's Church went through a series of tests: optical microscope, Scattering Electronic Microscope, thin sections, EDX, and cross-section. The optical microscope analysis of the thin sections revealed that the black crust layer is approximately 0.01mm, and in the sample there are perfectly shaped ooides, which is characteristic to this type of limestone. The SEM analysis shows a resedimentation layer on the surface of the black crust, which occurred probably due to the effect of acid rain. Further information regarding the results of the test will be presented on the poster.

  20. Euroopa parimaks filmiks sai Michael Haneke "Valge lint" / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2009-01-01

    Euroopa Filmiakadeemia auhindadest: parima filmiauhinna sai Saksamaal Bochumis toimunud tseremoonial Michael Haneke "Valge lint", mille eest Haneke sai ka parima režissööri ja stsenaristi auhinna. Parimaks meesnäitlejaks pärjati Tahar Rahim ("Un Prophete"), parimaks naisnäitlejaks Kate Winslet ("The Reader"), publikupreemia sai Danny Boyle'i "Rentslimiljonär. Ka teistest võitjatest

  1. Demonstration of a very inexpensive, turbidimetric, real-time, RT-LAMP detection platform using shrimp Laem-Singh virus (LSNV) as a model.

    Science.gov (United States)

    Arunrut, Narong; Suebsing, Rungkarn; Withyachumnarnkul, Boonsirm; Kiatpathomchai, Wansika

    2014-01-01

    Rapid and accurate detection of pathogens under field laboratory conditions is necessary for effective control of veterinary pathogens. Here we describe a prototype, portable, pathogen detection device developed for single tube, real-time, reverse transcription, loop-mediated isothermal amplification (RT-LAMP) using Laem-Singh virus (LSNV) as a model. LSNV is an RNA virus and a component cause of growth retardation in black tiger shrimp. We chose its RNA-dependent RNA polymerase (RdRp) gene as the target for our tests. The basis for detection was measurement of turbidity arising from formation of a white, insoluble magnesium pyrophosphate precipitate byproduct upon amplification of the RdRp target sequence from 100 ng template RNA extracted from shrimp. The measurement device consisted of a heating block to maintain constant temperature in the RT-LAMP reaction for 8 Eppindorf sample tubes, a light-emitting diode (LED) light source providing red light emission at 650 nm wavelength to pass through sample tubes, a light dependent resistance (LDR) photo-detector and a software program to report turbidity events and could potentially be marketed for under US$3000. The device was connected to a computer to display real-time results in a variety of formats. The optimized protocol for LSNV detection consisted of incubation of the sample tubes at 65 °C for 1 h during which turbidity was continuously measured, and quantitative results could be obtained by reaction time measurement. The sensitivity of detection was comparable to that of conventional nested RT-PCR and there was no cross reaction with other common shrimp viruses. The device was used for quantitative measurement of relative copy numbers of LSNV RdRp in 8 shrimp tissues and they were found to be highest in the gills followed in order by the lymphoid organ and hemolymph (p ≤ 0.05). This platform can be easily adapted for detection of other pathogens under field laboratory settings.

  2. Demonstration of a very inexpensive, turbidimetric, real-time, RT-LAMP detection platform using shrimp Laem-Singh virus (LSNV as a model.

    Directory of Open Access Journals (Sweden)

    Narong Arunrut

    Full Text Available Rapid and accurate detection of pathogens under field laboratory conditions is necessary for effective control of veterinary pathogens. Here we describe a prototype, portable, pathogen detection device developed for single tube, real-time, reverse transcription, loop-mediated isothermal amplification (RT-LAMP using Laem-Singh virus (LSNV as a model. LSNV is an RNA virus and a component cause of growth retardation in black tiger shrimp. We chose its RNA-dependent RNA polymerase (RdRp gene as the target for our tests. The basis for detection was measurement of turbidity arising from formation of a white, insoluble magnesium pyrophosphate precipitate byproduct upon amplification of the RdRp target sequence from 100 ng template RNA extracted from shrimp. The measurement device consisted of a heating block to maintain constant temperature in the RT-LAMP reaction for 8 Eppindorf sample tubes, a light-emitting diode (LED light source providing red light emission at 650 nm wavelength to pass through sample tubes, a light dependent resistance (LDR photo-detector and a software program to report turbidity events and could potentially be marketed for under US$3000. The device was connected to a computer to display real-time results in a variety of formats. The optimized protocol for LSNV detection consisted of incubation of the sample tubes at 65 °C for 1 h during which turbidity was continuously measured, and quantitative results could be obtained by reaction time measurement. The sensitivity of detection was comparable to that of conventional nested RT-PCR and there was no cross reaction with other common shrimp viruses. The device was used for quantitative measurement of relative copy numbers of LSNV RdRp in 8 shrimp tissues and they were found to be highest in the gills followed in order by the lymphoid organ and hemolymph (p ≤ 0.05. This platform can be easily adapted for detection of other pathogens under field laboratory settings.

  3. Feasibility of dsRNA treatment for post-clearing SPF shrimp stocks of newly discovered viral infections using Laem Singh virus (LSNV) as a model.

    Science.gov (United States)

    Saksmerprome, Vanvimon; Charoonnart, Patai; Flegel, Timothy W

    2017-05-02

    Using post-larvae derived from specific pathogen free (SPF) stocks in penaeid shrimp farming has led to a dramatic increase in production. At the same time, new pathogens of farmed shrimp are continually being discovered. Sometimes these pathogens are carried by shrimp and other crustaceans as persistent infections without gross signs of disease. Thus it is that a 5-generation stock of Penaeus monodon SPF for several pathogens was found, post-stock-development, to be persistently-infected with newly-discovered Laem Singh virus (LSNV). In this situation, the stock developers were faced with destroying their existing stock (developed over a long period at considerable cost) and starting the whole stock development process anew in order to add LSNV to its SPF list. As an alternative, it was hypothesized that injection of complementary dsRNA into viral-infected broodstock prior to mating might inhibit replication of the target virus sufficiently to reduce or eliminate its transmission to their offspring. Subsequent selection of uninfected offspring would allow for post-clearing of LSNV from the existing stock and for conversion of the stock to LSNV-free status. Testing this hypothesis using the LSNV-infected stock described above, we found that transmission was substantially reduced in several treated broodstock compared to much higher transmission in buffer-injected broodstock. Based on these results, the model is proposed for post-clearing of SPF stocks using dsRNA treatment. The model may also be applicable to post-clearing of exceptional, individual performers from grow-out ponds for return to a nucleus breeding center. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Michael Marinov memorial volume multiple facets of quantization and supersymmetry

    CERN Document Server

    Vainshtein, A I

    2002-01-01

    This book is dedicated to the memory of Michael Marinov, the theorist who, together with Felix Berezin, introduced the classical description of spin by anticommuting Grassmann variables. It contains original papers and reviews by physicists and mathematicians written specifically for the book. These articles reflect the current status and recent developments in the areas of Marinov's research: quantum tunneling, quantization of constrained systems, supersymmetry, and others. The personal recollections included portray the human face of M Marinov, a person of great knowledge and integrity.

  5. Michael Kohlhaas or the Germans and Their Law

    Directory of Open Access Journals (Sweden)

    Heike Jung

    2014-12-01

    Full Text Available Asked to pick a single representative ‘German’ piece for a discourse on ‘Law and Literature’ one almost inevitably ends up with Kleist’s tale Michael Kohlhaas. It seems to be the literary incarnation of the German stance vis-à-vis the law. It is all about horses; it could just as well be about dogs. Kohlhaas fights a devastating battle, using legal means and outright violence, even warfare, for their recovery in good shape. Victorious eventually with his legal actions, he is happy to trade in his own life for this victory, thus giving an extreme example for the nice line between being in the right and pursuing this position with disproportionate rigour. Of course, the interpretations of Michael Kohlhaas (which, in its complete version, dates of 1810 have varied from epoch to epoch as well as from reader to reader. It is not possible to rehearse the bulk of ‘Kohlhaas literature’. In comparing legal cultures, it might be of interest to look into the question why such a somber story on the law forms part and will continue to form part of the German cultural heritage. Si se tiene que elegir un único representante “alemán” para una ponencia sobre “derecho y literatura”, es inevitable optar por la obra de Kleist, Michael Kohlhaas. Parece la encarnación literaria de la posición alemana hacia el derecho. El libro trata de caballos; también podría tratar sobre perros. Kohlhaas libra una batalla devastadora usando medios legales y la violencia pura y dura, incluso la guerra, para que se recuperen en buena forma. Finalmente resulta ganador mediante acciones legales, está contento de dedicar su propia vida para conseguir esta victoria, dando así un ejemplo extremo de la línea que existe entre tener la razón y seguir esta posición con un rigor desproporcionado. Por supuesto, las interpretaciones de Michael Kohlhaas (publicado en 1810 han variado de una época a otra, y de un lector a otro. No es posible revisar el grueso de

  6. Hechter Michael, Horne Christine (Dir., Theories of Social Order

    Directory of Open Access Journals (Sweden)

    Yves Laberge

    2011-09-01

    Full Text Available Cette anthologie méconnue examine le concept fondamental de l’ordre social en 34 textes tantôt anciens (de Tocqueville, Marx, Engels, Simmel ou relativement récents (le chapitre 19 comparant les groupes humains aux fourmis date de 2007. Ici, l’ordre social est compris de diverses manières ; Michael Hechter et Christine Horne rappellent d’emblée que « sans ordre social, il ne peut y avoir ni agriculture, ni industrie, ni commerce, ni investissement, ni développement économique, ni justice, n...

  7. Estratégia competitiva: Michael Porter 30 anos depois

    OpenAIRE

    Manuel Portugal Ferreira; Fernando A. Ribeiro Serra; Marcelo Lopes Carneiro; Aline Botelho Schneider

    2009-01-01

    Os estudos de estratégia têm sido muito influenciados pelos trabalhos de Michael Porter, em todas as suas fases, como as cinco forças, as estratégias genéricas, a cadeia de valor e as vantagens competitivas das nações. Neste artigo, analisou-se a influência de Porter nos trabalhos brasileiros em estratégia, a partir dos trabalhos selecionados e apresentados no EnANPAD. No levantamento para a análise dos artigos, considerando 10 anos de EnANPAD (1997-2006), foram selecionados 46 artigos. A ide...

  8. The Correspondence of Michael Faraday Pt 6 1860-1867

    CERN Document Server

    Frank, James

    2012-01-01

    Michael Faraday (1791-1867) was one of the most important men of science in nineteenth century Britain. His discoveries of electro-magnetic rotations (1821) and electro-magnetic induction (1831) laid the foundations of the modern electrical industry. His discovery of the magneto-optical effect and diamagnetism (1845) led him to formulate the field theory of electro-magnetism, which forms one of the cornerstones of modern physics.These and a whole host of other fundamental discoveries in physics and chemistry, together with his lecturing at the Royal Institution, his work for the state (includi

  9. Glutathione Adduct Patterns of Michael-Acceptor Carbonyls.

    Science.gov (United States)

    Slawik, Christian; Rickmeyer, Christiane; Brehm, Martin; Böhme, Alexander; Schüürmann, Gerrit

    2017-02-22

    Glutathione (GSH) has so far been considered to facilitate detoxification of soft organic electrophiles through covalent binding at its cysteine (Cys) thiol group, followed by stepwise catalyzed degradation and eventual elimination along the mercapturic acid pathway. Here we show that in contrast to expectation from HSAB theory, Michael-acceptor ketones, aldehydes and esters may form also single, double and triple adducts with GSH involving β-carbon attack at the much harder N-terminus of the γ-glutamyl (Glu) unit of GSH. In particular, formation of the GSH-N single adduct contradicts the traditional view that S alkylation always forms the initial reaction of GSH with Michael-acceptor carbonyls. To this end, chemoassay analyses of the adduct formation of GSH with nine α,β-unsaturated carbonyls employing high performance liquid chromatography and tandem mass spectrometry have been performed. Besides enriching the GSH adductome and potential biomarker applications, electrophilic N-terminus functio-nalization is likely to impair GSH homeostasis substantially through blocking the γ-glutamyl transferase catalysis of the first breakdown step of modified GSH, and thus its timely reconstitution. The discussion includes a comparison with cyclic adducts of GSH and furan metabolites as reported in literature, and quantum chemically calculated thermodynamics of hard-hard, hard-soft and soft-soft adducts.

  10. En recuerdo de Michael Heyd (1943-2014

    Directory of Open Access Journals (Sweden)

    Peset, José Luis

    2016-12-01

    Full Text Available In homage to Professor Michael Heyd, in this paper are presented some of the main influences of his book “Be sober and reasonable” (1995 on several studies about Robert Burton and his classical book The Anatomy of Melancholy. Mainly, the relations between medicine and religious thought are briefly followed, looking for confluences between North and South Europe. The influence of “enthusiasm” and “melancholy” in the history of European thought was always an important interest in the life and teaching of this very intelligent researcher of cultural history.En homenaje al Profesor Michael Heyd, se muestran en este artículo algunas de las influencias principales de su libro “Be sober and reasonable” (1995 en algunos estudios sobre el clásico libro de Robert Burton The Anatomy of Melancholy. En especial, se siguen brevemente las relaciones entre la medicina y el pensamiento religioso, buscando confluencias entre el norte y el sur de Europa. La influencia de “entusiasmo” y “melancolía” en la historia del pensamiento europeo fue siempre un importante interés en la vida y la enseñanza de este muy inteligente investigador en historia cultural.

  11. Asymmetric Michael Addition of Activated Alkenes to Nitro Alkenes Catalyzed by Organic Catalyst

    Institute of Scientific and Technical Information of China (English)

    XUE Dong; CHEN Yong-Chun; CUI Xin; WANG Qi-Wei; ZHU Jin; DENG Jin-Gen

    2003-01-01

    @@ Enantioselective Michael addition is one of the most powerfulbond-forming reaction in organic synthesis. [1] A mong the Michael acceptors, nitro alkenes are very attractive, because the nitro group is the most electron-withdrawing group known and it can serve as masked functionality to be further transformed after the addition has taken place. [2] Recently, asymmetric Michael reactions catalyzed by organic catalyst have draw much attention.[3

  12. Enantioselective Synthesis of β-(3-Hydroxypyrazol-1-yl)ketones Using An Organocatalyzed Michael Addition Reaction

    Science.gov (United States)

    Gogoi, Sanjib; Zhao, Cong-Gui; Ding, Derong

    2009-01-01

    β-(3-Hydroxypyrazol-1-yl)ketones have been prepared in high yields and excellent enantioselectivities (94–98% ee) via a Michael addition reaction between 2-pyrazolin-5-ones and aliphatic acyclic α,β-unsaturated ketones using 9-epi-9-amino-9-deoxyquinine as the catalyst. These results account for the first example of an aza-Michael addition of the ambident 2-pyrazolin-5-one anion to a Michael acceptor. PMID:19415906

  13. BUS 320 Assignment 2: Case Study: Michael Dell—The Man Behind Dell

    OpenAIRE

    Laynebaril

    2017-01-01

    BUS 320 Assignment 2: Case Study: Michael Dell—The Man Behind Dell   Click Link Below To Buy: http://hwcampus.com/shop/bus-320-assignment-2-case-study-michael-dell-the-man-behind-dell/ Or Visit www.hwcampus.com   Assignment 2: Case Study: Michael Dell—The Man Behind Dell Presentation (Change Management) Michael Dell began building and selling computers from his dorm room at age 19. He dropped out of the University of Texas when his sales hit $60 million and has nev...

  14. Comments on the paper “Temperature dependence of bulk modulus and second-order elastic constants” by P.P. Singh and M. Kumar [Physica B 344 (2004) 41

    Science.gov (United States)

    Singh, K. S.

    2005-05-01

    Singh and Kumar have questioned the validity of the Mie-Grüneisen equation using an incorrect formulation. The Suzuki equation for thermal expansivity has been expressed by them in terms of thermal pressure using a wrong definition. The formulations already reported in the literature have been rediscovered by them and redesignated as the Kumar formulation. In the present communication we have reinforced the validity of the Mie-Grüneisen EOS using the correct definition of thermal pressure in the Suzuki formulation.

  15. Proline Based Chiral Ionic Liquids for Enantioselective Michael Reaction

    Directory of Open Access Journals (Sweden)

    Kaoru Nobuoka

    2014-01-01

    Full Text Available Chiral ionic liquids, starting from (S-proline, have been prepared and evaluated the ability of a chiral catalyst. In Michael reaction of trans-β-nitrostyrene and cyclohexanone, all the reactions were carried out under homogeneous conditions without any solvent except for excess cyclohexanone. The chiral ionic liquid catalyst with the positive charge delocalized bulky pyrrolidinium cation shows excellent yields (up to 92%, diastereoselectivities (syn/anti = 96/4, and enantioselectivities (up to 95% ee and could be reused at least three times without any loss of its catalytic activity. Such results demonstrated a promising new approach for green and economic chiral synthesis by using the chiral ionic liquids as a chiral catalyst and a chiral medium.

  16. Profiles in medical courage: Michael Wilkins and the Willowbrook School

    Directory of Open Access Journals (Sweden)

    Robbins RA

    2012-03-01

    Full Text Available No abstract available. Article truncated at 150 words. “Never doubt that a small group of thoughtful, committed citizens can change the world. Indeed, it is the only thing that ever has. "- Margaret Mead With this article we begin an intermittent series on physicians who displayed courage in trying to help their patients. Although there are many examples, hopefully what will be illustrated are examples of the lesser known doctors who identified problems and stood up to address them. Few remember the controversy surrounding the now closed Willowbrook School and Dr. Michael Wilkins’ involvement. However, Wilkins’ courage in advocating for change not only resulted in substantial improvement in conditions at the school but also led to the Civil Rights of Institutionalized Persons Act (CRIPA of 1980.Wilkins was originally from Kansas City and graduated from the University of Missouri School of Medicine in 1967 (1. He left Missouri to do his pediatric internship and complete his military obligation…

  17. Solvent-free Michael addition reaction of fluorene with chalcon

    Institute of Scientific and Technical Information of China (English)

    Fu Feng

    2011-01-01

    A series of novel Michael addition products of fluorene to chalcone were obtained in the presence of sodium hydroxide under solvent-free condition. The advantages of this procedure were mild reaction conditions, simple protocol, and high yields. The structures of the products were characterized by IR, 1H NMR, MS and X-ray diffraction. The crystal of the new compound 3 h is y= 64.2440(10)°, V = 2.4137(3) nm3, Z= 4, Dc=1.220 g/cm3, μ = 0.286 mm-1, F(000) = 920, R = 0.0656 and wR = 0.1554 for 5664 observed reflection with I > 2σ(I).

  18. Michael Longley’s Father: Memory, Mourning and History

    Directory of Open Access Journals (Sweden)

    Barry Sloan

    2012-03-01

    Full Text Available Michael Longley’s father has been a recurring presence in the poet’s work from his earliest to his most recent collection. This paper examines the exceptional strength of that bond reflected in the varied and changing ways in which the poet has responded to it – memorizing and mourning his loss; discovering through his father’s First World War stories a means of memorialising loss of life in contemporary conflicts and a way of facing the history of the twentieth century; confronting his own ageing and sense of mortality; and marking the specific, but also representative, generational history of his family. Close readings of key poems are offered to highlight Longley’s skills in meeting his own exacting standards of aesthetic propriety and moral and social responsibility for writers of elegy in order to avoid either exploitation of tragedy and loss, or facile gestures of consolation.

  19. Michael Tenzer, ed., Analytical Studies in World Music

    OpenAIRE

    Martin,Denis-Constant

    2007-01-01

    Pour Michael Tenzer, professeur de musique à l’Université de Colombie britannique et spécialiste (analyste et interprète) de musique pour gamelan, la réunion des textes proposés dans cet ouvrage a deux objectifs : construire une théorie de la musique dans le monde qui s’émancipe des oppositions entre musiques « classiques » et « populaires », « occidentales » et « non occidentales », c’est-à-dire jeter les bases d’une théorie générale de la musique et, pour ce faire, montrer que l’analyse mus...

  20. A Study of Postmodern Narrative in Michael Cunningham's The Hours

    Directory of Open Access Journals (Sweden)

    Hajar Abbasi Narinabad

    2012-09-01

    Full Text Available This project aims at providing a detailed analysis of the major features of the theory of postmodern narrative and at going through the novel The Hours by the American writer Michael Cunningham concentrating on some postmodern narrative techniques. To do so, the researcher goes through the theories set forth by some postmodern theoreticians like Roland Barthes, Jacque Derrida, Jean-François Lyotard and Julia Kristeva to investigate the postmodern narrative techniques and elements used in the novel. The researcher first examines the theories and then critically applies them on the novel. The article goes through the most eminent elements of postmodern narrative including intertextuality, stream of consciousness style, fragmentation and representation respectively which are delicately utilized in The Hours. The article concludes by recommending a few directions for the further research.

  1. Asymmetric synthesis of functionalized cyclohexanes bearing five stereocenters via a one-pot organocatalytic Michael-Michael-1,2-addition sequence.

    Science.gov (United States)

    Chauhan, Pankaj; Urbanietz, Gregor; Raabe, Gerhard; Enders, Dieter

    2014-07-04

    A highly stereoselective one-pot procedure involving an enantioselective Michael addition promoted by low loading of an amino-squaramide catalyst followed by an achiral base catalyzed domino Michael-Knoevenagel-type 1,2-addition sequence provides efficient access to fully substituted cyclohexanes bearing five contiguous stereogenic centers in good yields (68-86%) and excellent stereoselectivities (>30 : 1 dr and 96-99% ee).

  2. Estratégia competitiva: Michael Porter 30 anos depois

    Directory of Open Access Journals (Sweden)

    Manuel Portugal Ferreira

    2009-12-01

    Full Text Available Os estudos de estratégia têm sido muito influenciados pelos trabalhos de Michael Porter, em todas as suas fases, como as cinco forças, as estratégias genéricas, a cadeia de valor e as vantagens competitivas das nações. Neste artigo, analisou-se a influência de Porter nos trabalhos brasileiros em estratégia, a partir dos trabalhos selecionados e apresentados no EnANPAD. No levantamento para a análise dos artigos, considerando 10 anos de EnANPAD (1997-2006, foram selecionados 46 artigos. A identificação e seleção dos artigos envolveram os seguintes critérios: busca complementar por palavra-chave Porter na base de dados do EnANPAD; avaliação dos títulos e resumos dos artigos apresentados na área de estratégia entre 1997 e 2006, bem como na íntegra quando necessário. Procedeu-se também à análise das referências utilizadas nos artigos e o posicionamento dos autores em relação às tipologias de Porter. Como resultado, verificou-se que Michael Porter é um autor com grande influência nas pesquisas acadêmicas de estratégia. Seus estudos mais utilizados são os da análise da indústria e das estratégias genéricas, e também se verificou que a maioria dos estudos analisados é favorável aos seus conceitos, mesmo existindo pesquisas contrárias.

  3. Domino Mukaiyama-Michael reactions in the synthesis of polycyclic systems

    NARCIS (Netherlands)

    Sarabèr, F.C.E.; Dratch, S.; Bosselaar, G.; Jansen, B.J.M.; Groot, de Æ.

    2006-01-01

    Good results were obtained in the Mukaiyama-Michael reaction of the silyl enol ether of cyclohexanone with 2-methyl-2cyclopentenone and carvone, with transfer of the silyl group to the receiving enone and with TrSbCl6 as catalyst. A second Mukaiyama-Michael reaction of this new silyl enol ether with

  4. Asymmetric Michael Reaction of Malononitrile Catalyzed by Chiral Ru(Ⅱ) Complex and Achiral Base

    Institute of Scientific and Technical Information of China (English)

    MA Ya-Ping; XING Zhi-Kui; ZHU Jin; CUI Xin; CUN Lin-Feng; DENG Jin-Gen

    2003-01-01

    @@ Michael addition reactions represent one of the most important carbon-carbon bond forming reactions in modern synthetic organic chemistry. [1 ~3] We achieved catalytic enantioselective Michael addition reactions of malononitrile with chiral vicinal diamine-Ru(Ⅱ) complex in the presence of achiral base. High yields and moderate ee were observed.

  5. 75 FR 22436 - Michael Williams-Control Exemption-St. Maries River Railroad, Inc.

    Science.gov (United States)

    2010-04-28

    ... Surface Transportation Board Michael Williams-Control Exemption-St. Maries River Railroad, Inc. Michael Williams (applicant),\\1\\ a noncarrier, has filed a verified notice of exemption to acquire control of St... from STMA's parent, Potlatch Land & Lumber, LLC, by Williams Group, Inc. (WG).\\2\\ Applicant...

  6. Domino Mukaiyama-Michael reactions in the synthesis of polycyclic systems

    NARCIS (Netherlands)

    Sarabèr, F.C.E.; Dratch, S.; Bosselaar, G.; Jansen, B.J.M.; Groot, de Æ.

    2006-01-01

    Good results were obtained in the Mukaiyama-Michael reaction of the silyl enol ether of cyclohexanone with 2-methyl-2cyclopentenone and carvone, with transfer of the silyl group to the receiving enone and with TrSbCl6 as catalyst. A second Mukaiyama-Michael reaction of this new silyl enol ether with

  7. A Response to Michael Newman's "Calling Transformative Learning into Question: Some Mutinous Thoughts"

    Science.gov (United States)

    Cranton, Patricia; Kasl, Elizabeth

    2012-01-01

    This article presents the authors' response to Michael Newman's "Calling Transformative Learning into Question: Some Mutinous Thoughts". The authors begin by noting their appreciation of Michael Newman's challenge to transformative learning theory. In their response, the authors review and comment on the fatal flaws presented by Newman and then…

  8. Markets, Marx, Modernity and Mathematics Education: A Response to Michael Apple.

    Science.gov (United States)

    Gates, Peter

    This paper is a response to Michael Apple's paper, "What Postmodernists Forget: Cultural Capital and Official Knowledge." The paper advocates Michael's identification of the current dangers and processes of the growth of new right ideologies in the development of subjectivity, society, and education. The differences in success in the education…

  9. Gender, migration and agency: developing a “hauntology” of new becomings in Shauna Singh Baldwin’s Devika and in Ginu Kamani’s Just between Indians = Gênero, migração e agência: o desenvolvimento de uma ‘hauntologia’ de novas transformações em Devika de Shauna Singh Baldwin e Just between Indians de Ginu Kamani

    Directory of Open Access Journals (Sweden)

    Delphine Munos

    2011-01-01

    Full Text Available In recent short stories written by diasporic Indian women writers, changes in terms of location or national identity are generally depicted as providing significant opportunities for Indian women to challenge and revise culturally-inscribed gender roles. In two collections of short stories written respectively by Ginu Kamani and Shauna Singh Baldwin, Junglee Girl and English Lessons and Other Stories, not only are ghosts employed to rupture boundaries between the living and the dead, but they also represent enabling presences which authorize female voices by resurrecting stories of women that have been silenced or forgotten. In these two books, the emergence of the archaic is recurrently tinged with liberating undertones since it opens up new spaces for identity by countering gendered expectations of ‘acceptable’ behaviour and by constructing alternative realities. My essay will therefore focus on the central metaphors of female ghosts and doubles as transitional figures through which women in transit empower themselves. My aim is to show how culturallydisplaced women appropriate the uncanny so as to engender new identities and assert the value of individual female experience. In these haunted narratives, I will contend, women move from a ghostly time of repetition to a ‘hauntology’ of new becomings.Nos contos contemporâneos de escritoras indianas diaspóricas, asmudanças em locação ou identidade nacional são em geral descritas como fatores que proporcionam oportunidades significativas para que as mulheres indianas desafiem e revisem os papeis de gênero culturalmente inscritos. Em duas coleções de contos, Junglee Girl e English Lessons and Other Stories, escritos respectivamente por Ginu Kamani e Shauna Singh Baldwin, os fantasmas são introduzidos não apenas para quebrar as fronteiras entre os vivos e os mortos, mas para representarem ocasiões que autorizam as vozes femininas pararessuscitar histórias de vida feminina que

  10. Note on: 'EMDPLER: A F77 program for modeling the EM response of dipolar sources over the non-magnetic layer earth models' by N.P. Singh and T. Mogi, Computers & Geosciences 36 (2010) 430-440

    Science.gov (United States)

    Jamie, Majid; Mirzaei, Saeid; Mirzaei, Mahmoud

    2017-01-01

    In this paper some mistakes arising in Singh and Mogi (2010) that are: (1) wrong formulation of the intrinsic impedance of the layers of an N-layered earth (Zi) and reflection coefficient of the EM wave in TM-mode (rTM), (2) using wrong and the very same algorithms for computing reflection coefficients of the EM wave in both the TE- and the TM-mode (rTE and rTM) and (3) using flawed algorithms for computing phase and normalized phase values, relating to electric and magnetic components of the EM wave, are noted and corrected form of these mistakes are presented. Moreover, in order to illustrate how these mistakes can affect forward modeling results different two- and three-layered earth models, the same as the models used in Singh and Mogi (2010), are chosen; afterwards EMDPLER and corrected version of this program, presented in this paper titled "EMDPLER_Corr", are conducted on these models and real and imaginary parts of Hz and Hy components of the magnetic field intensity, their normalized amplitudes (|Hz /Hz0|and|Hy /Hy0 |) and the corresponding normalized phases are computed, plotted versus frequency and compared with each other.

  11. 77 FR 30047 - Notice of Opportunity for Public Comment on Surplus Property Release at Michael J Smith Field...

    Science.gov (United States)

    2012-05-21

    ... Michael J Smith Field, Beaufort, NC AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice... approximately 7.5 acres of airport property, located at the Michael J Smith Field, be used for aeronautical... Authority to release approximately 7.5 acres of airport property at the Michael J Smith Field. The...

  12. 75 FR 62635 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Science.gov (United States)

    2010-10-12

    ... AFFAIRS Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program... needed to determine patients' satisfaction with services provided by or through the Michael E. DeBakey.... Title: Patient Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form 10-0476. OMB...

  13. A Musical Italy: Michael W. Balfe’s Italian Experiences

    Directory of Open Access Journals (Sweden)

    Basil Walsh

    2016-06-01

    Full Text Available The Dublin-born musician, Michael W. Balfe, was a singer, composerand conductor whose brilliant musical career was heavily influenced byformative experiences in Italy. In 1825, Balfe, interested in broadeninghis musical studies first went to Paris where he was introduced to thegreat composers, Luigi Cherubini and Gioachino Rossini, who took apersonal interest in him and his musical talents. On the advice of Rossinihe spent the next few years in Italy studying singing with the famousRossini singer, Filippo Galli, and taking music composition lessonsfrom Ferdinando Paer, in Rome. Later in Milan he studied harmonyand counterpoint with Vincenzo Federici. By 1831, when he was only23 years old, his first three operas had been produced in Palermo, Pavia,and Milan. He returned to London in August 1835, participatingwith the great Lablache, Tamburini, Rubini and Grisi in a concert inVauxhall Gardens. In 1834 he made his debut at La Scala, Milan, singingopposite the renowned mezzo-soprano, Maria Malibran in Rossini’sOtello. He appeared again with Malibran in Venice early in 1835,singing once more in Rossini and Bellini operas. Balfe worked as a singerand composer throughout the Italian peninsula/states during the years,1825-1835 and this article will chart these experiences and demonstratehow the time he spent in Italy and the people he met, influenced hislife and later career as an important and popular European composer.

  14. El fetiche etnográfico de Michael Taussig

    Directory of Open Access Journals (Sweden)

    Matthew Carlin

    2014-01-01

    Full Text Available El antropólogo Michael Taussig ha producido una gran cantidad de trabajo etnográfico sobre América Latina en el que toma por objeto la universalidad de la cultura burguesa y en el que, al reorientar la mirada del etnógrafo hacia los elementos embriagantes y orgiásticos de la vida, atenúa las líneas que dividen ciencia y arte. En este ensayo tengo la intención de mostrar lo siguiente: 1 que sus etnografías sobre magia, violencia y el Es-tado, están enraizadas en su priorización del mundo fenomenológico y en una concepción materialista en deuda con la teoría estética alemana del si-glo XIX y con la antropología especulativa de Karl Marx y Walter Benjamin; 2 que su proyecto etnográfico no consiste en la eliminación de la ciencia del ámbito de la etnografía, sino en disminuir el papel de la explicación en favor de una forma de escritura que, como el arte, trabaja para refundar las imágenes del mundo.

  15. Michael Field’s “A Dance of Death”

    Directory of Open Access Journals (Sweden)

    LeeAnne Richardson

    2012-03-01

    Full Text Available The 1912 poem "A Dance of Death" by Michael Field (pen name of Katherine Bradley and her niece Edith Cooper depicts Salome in an alternate version of the biblical story: this Salome dances on a frozen river, falls through the ice, and is decapitated on a jagged edge. Nonetheless, her beautiful head continues dancing over the frozen river. This poem is highly unusual, especially in the context of the other poems in the postconversion volume Poems of Adoration, because it questions, rather than submits to, authority. In re-writing a familiar Christian tale, as well as a familiar decadent theme, Field uses the poem to assert the supremacy of their artistic vision, which (despite their ardent Catholicism cannot be subject to any law outside themselves. Like the continually dancing head of Salome, which continues to create beauty even after nature (and perhaps God has struck it down, the poet is subjugate only to her own law and creates without boundaries or restrictions on her art. Bradley and Cooper were acutely aware of their authorial persona (actively taking not only a masculine but also a singular poetic identity, and their mode of reconciling the apparent contradictions of this identity are mirrored in their presentation of Salome in a "Dance of Death."

  16. Subjetividade e defesa na obra de Michael Balint

    Directory of Open Access Journals (Sweden)

    Renata Mello

    2008-01-01

    Full Text Available Currently we can observe the diffusion of the so-called tough patients in psychoanalytic clinic. These patients have proven resistant to the classic psychoanalysis technique, leading to the necessity of relying on their psychic dynamics, aiming at a broader understanding of what is at stake in these cases. It can be observed that the subjectivation process relates to a precocious traumatic experience that touches the relation of the individual with what is external to him. Because of the overwhelming intensity provoked by the trauma, elementary protection measures are mobilized in order to prevent a narcissistic collapse. The defense then becomes the preferred way through which psychism constitutes itself, which translates into a meaningful impoverishment of subjective life. In an attempt to understand this dynamic and propose a direction for the psychic treatment, we will resort to Michael Balint¿s ideas about primary object relations, as his thinking offers important elements for a renewal of the understanding of both the analytical practice and the very psychic dynamic we currently see. In regards to Balint¿s ideas, we will hold on to his primary love theory and to the question of the modalities of defensive links - ocnophilia and philobatism - given the lack of loving of the primordial objects, ideas that can provide subsidies to deal with these tough patients.

  17. Eesti disain on kõva, ent see tuleb moondada ekspordiks / Michael Thomson ; interv. Urmas Oja

    Index Scriptorium Estoniae

    Thomson, Michael

    2008-01-01

    Euroopa Disainiassotsiatsioonide Liidu presidendi ja Tallinnas toimunud festivali Disainiöö Eesti disainiauhinna Bruno žürii juhi Michael Thomsoni arvamus eesti disainist ning disainipoliitika vajalikkusest Eestis. Auhinnasaajate nimekiri

  18. Theory and practice in action: the contributions of Michael Perkins to clinical linguistics.

    Science.gov (United States)

    Damico, Jack S; Lynch, Karen E

    2013-01-01

    This article reviews the scholarly contributions of Michael R. Perkins in the discipline of clinical linguistics and provides some indication of the reasons that he has been so successful. Three primary attributes were described through an analysis of his publications.

  19. Tõsine fotoelamus Dubrovnikus / Wade Goddard, Heidi Levine, Michael Robinson Chaver ; interv. Ahto Külvet

    Index Scriptorium Estoniae

    Goddard, Wade

    2007-01-01

    Dubrovniku vanalinnas asub Sõjafotokeskus. Intervjuu keskuse asutaja, kanadalasest fotograafi Wade Goddardi ja kahe seal augustis avatud näitusel osalenud fotograafi Heidi Levine'i ja Michael Robinson Chavez'iga. Sõjafotograafi tööst

  20. Reports of the working groups / Eino Tamm, Sahlin Michael, Valve Kirsipuu...[jt.

    Index Scriptorium Estoniae

    1999-01-01

    Töögruppide "EU enlargement and relevant institutional reforms" (juhatajad Eino Tamm, Michael Sahlin) ja "Maintaining of competitiveness of Estonia and other candidate countries" (juhatajad Valve Kirsipuu, Terry Calbom) tööst. Autor: Reformierakond

  1. Tõsine fotoelamus Dubrovnikus / Wade Goddard, Heidi Levine, Michael Robinson Chaver ; interv. Ahto Külvet

    Index Scriptorium Estoniae

    Goddard, Wade

    2007-01-01

    Dubrovniku vanalinnas asub Sõjafotokeskus. Intervjuu keskuse asutaja, kanadalasest fotograafi Wade Goddardi ja kahe seal augustis avatud näitusel osalenud fotograafi Heidi Levine'i ja Michael Robinson Chavez'iga. Sõjafotograafi tööst

  2. High Blood Cholesterol Q&A Dr. Michael Lauer | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... high cholesterol research. Dr. Michael Lauer and his wife, Dr. Robin Avery, agree on the health benefits ... trial of the drug methotrexate in high-risk patients with vascular disease. We have come to appreciate ...

  3. Chiral Aminophosphines as Catalysts for Enantioselective Double-Michael Indoline Syntheses

    Directory of Open Access Journals (Sweden)

    Ohyun Kwon

    2012-05-01

    Full Text Available The bisphosphine-catalyzed double-Michael addition of dinucleophiles to electron-deficient acetylenes is an efficient process for the synthesis of many nitrogen-containing heterocycles. Because the resulting heterocycles contain at least one stereogenic center, this double-Michael reaction would be even more useful if an asymmetric variant of the reaction were to be developed. Aminophosphines can also facilitate the double-Michael reaction and chiral amines are more readily available in Nature and synthetically; therefore, in this study we prepared several new chiral aminophosphines. When employed in the asymmetric double-Michael reaction between ortho-tosylamidophenyl malonate and 3-butyn-2-one, the chiral aminophosphines produced indolines in excellent yields with moderate asymmetric induction.

  4. Dr. Michael DeBakey "is a magician of the heart…"

    Science.gov (United States)

    ... of Baylor's new Michael E. DeBakey Library and Museum. In a lengthy Christmas Day interview that year ... blood circulation. — 1706 Raymond de Vieussens, a French anatomy professor, first describes the structure of the heart's ...

  5. Reports of the working groups / Eino Tamm, Sahlin Michael, Valve Kirsipuu...[jt.

    Index Scriptorium Estoniae

    1999-01-01

    Töögruppide "EU enlargement and relevant institutional reforms" (juhatajad Eino Tamm, Michael Sahlin) ja "Maintaining of competitiveness of Estonia and other candidate countries" (juhatajad Valve Kirsipuu, Terry Calbom) tööst. Autor: Reformierakond

  6. Trimethylsilylethynyl ketones as surrogates for ethynyl ketones in the double Michael reaction.

    Science.gov (United States)

    Holeman, Derrick S; Rasne, Ravindra M; Grossman, Robert B

    2002-05-01

    Trimethylsilylethynyl ketones can be desilylated in the presence of a tethered carbon diacid and induced to undergo a double Michael reaction in situ. The trimethylsilylethynyl ketones can serve as surrogates of ethynyl ketones that are difficult to prepare or isolate.

  7. A Conversation with his Honour Chief Judge Michael Rozenes AO County Court of Victoria

    Directory of Open Access Journals (Sweden)

    Michael Rozenes

    2014-10-01

    Full Text Available VULJ Editors and invited students interviewed the Chief Judge of the County Court of Victoria, His Honour Michael Rozenes AO QC, on Tuesday 19 August 2014 at the College of Law & Justice, Victoria University.

  8. L-prolinol as a highly enantioselective catalyst for Michael addition of cyclohexanone to nitroolefins.

    Science.gov (United States)

    Chua, Pei Juan; Tan, Bin; Zeng, Xiaofei; Zhong, Guofu

    2009-07-15

    Though many chiral amines such as l-proline and its derivatives have proven to be versatile catalysts in many reactions, L-prolinol was seldom used as organocatalyst for reactions. Herein, we report the first L-prolinol catalyzed asymmetric Michael addition of cyclohexanone to nitroolefins in the presence of benzoic acid to afford Michael adducts with high diastereoselectivities (87:13->99:1) and enantioselectivities (82-96%).

  9. Note on: 'EMLCLLER-A program for computing the EM response of a large loop source over a layered earth model' by N.P. Singh and T. Mogi, Computers & Geosciences 29 (2003) 1301-1307

    Science.gov (United States)

    Jamie, Majid

    2016-11-01

    Singh and Mogi (2003) presented a forward modeling (FWD) program, coded in FORTRAN 77 called "EMLCLLER", which is capable of computing the frequency-domain electromagnetic (EM) response of a large circular loop, in terms of vertical magnetic component (Hz), over 1D layer earth models; computations at this program could be performed by assuming variable transmitter-receiver configurations and incorporating both conduction and displacement currents into computations. Integral equations at this program are computed through digital linear filters based on the Hankel transforms together with analytic solutions based on hyper-geometric functions. Despite capabilities of EMLCLLER, there are some mistakes at this program that make its FWD results unreliable. The mistakes in EMLCLLER arise in using wrong algorithm for computing reflection coefficient of the EM wave in TE-mode (rTE), and using flawed algorithms for computing phase and normalized phase values relating to Hz; in this paper corrected form of these mistakes are presented. Moreover, in order to illustrate how these mistakes can affect FWD results, EMLCLLER and corrected version of this program presented in this paper titled "EMLCLLER_Corr" are conducted on different two- and three-layered earth models; afterwards their FWD results in terms of real and imaginary parts of Hz, its normalized amplitude, and the corresponding normalized phase curves are plotted versus frequency and compared to each other. In addition, in Singh and Mogi (2003) extra derivations for computing radial component of the magnetic field (Hr) and angular component of the electric field (Eϕ) are also presented where the numerical solution presented for Hr is incorrect; in this paper the correct numerical solution for this derivation is also presented.

  10. A post-Byzantine creation: The archangel Michael triumphant and psychopomp

    Directory of Open Access Journals (Sweden)

    Leontakianakou Irini

    2009-01-01

    Full Text Available This paper deals with a specific iconographic type of Archangel Michael: he is shown bearing a soul in the form of a swaddled infant, while subduing an old man who is wearing only a loincloth. Who is Michael subduing? Three possible answers are considered: 1 the figure can be identified with Satan the fallen angel who, like Michael, has an immaterial nature and is commonly considered as his enemy par excellence; 2 he can also be an anonymous sinner, whose soul is depicted in Michael's hand; 3 finally, one could identify him with Hades, the god of the Underworld and personification of death, because he is depicted as an old man, semi-nude with a pronounced musculature, as well as because of the assimilation of Michael to God. Rather than making a single choice, the author proposes a combined interpretation of the image, which allows for the integration of all the aspects of Michael's cult (military, triumph over Satan, psychopomp, archangel of the Last Judgment and unifies the past (the fall of Satan, the present (death of a sinner and the future (Last Judgment.

  11. 76 FR 51424 - Satinder Dang, M.D.; Revocation of Registration

    Science.gov (United States)

    2011-08-18

    ... respect to a practitioner who engages in dispensing, DEA regulations require that the record include ``the... the revocation of Respondent's DEA Certificate of Registration, AD9234446, as a practitioner, as well... July 2007, Respondent and her husband Surinder Dang, ``who also possesses a DEA registration and shares...

  12. The CHINA CONNECTION: Michael Rossmann and his first encounter with me

    Institute of Scientific and Technical Information of China (English)

    Jia-huai Wang

    2010-01-01

    @@ "We would have never belived it, if it were not told by Dorothy Hodgkin," Michael Rossmann of Purdue University said to me. He was referring to what the late Nobel laureate Dorothy Hodgkin announced in an international meeting about the achievements of Chinese scientists in determining the crystal structure of insulin in early 70's. This significant contribution occurred at the time when China was still deeply entangled in the chaos of the Cultural Revolution, while even in the international community there were less than a dozen protein structures solved by scientists (Michael included) from a handful of countries. Michael and I sat in his cozy dinning room. While enjoying a breakfast with his favorite applesauce,observing a wild rabbit sneaking underneath the bush in the garden, we had a long chat. That was dudng my first visit to his lab in West Lafayette in 1980.

  13. Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions

    Directory of Open Access Journals (Sweden)

    Giovanna Bosica

    2016-06-01

    Full Text Available Aza-Michael reactions between primary aliphatic and aromatic amines and various Michael acceptors have been performed under environmentally-friendly solventless conditions using acidic alumina as a heterogeneous catalyst to selectively obtain the corresponding mono-adducts in high yields. Ethyl acrylate was the main acceptor used, although others such as acrylonitrile, methyl acrylate and acrylamide were also utilized successfully. Bi-functional amines also gave the mono-adducts in good to excellent yields. Such compounds can serve as intermediates for the synthesis of anti-cancer and antibiotic drugs.

  14. Michael Goodsite gæsteprofessor på Thunderbird School of Global Management

    DEFF Research Database (Denmark)

    Pedersen, Jens Christian

    2010-01-01

    Professor Michael Goodsite er blevet udnævnt til "Visiting Professor of Global Processes and Senior Research Fellow in Climate Strategy" ved Thunderbird School of Global Management, som har verdens højst rangerede MBA uddannelse inden for international handel.......Professor Michael Goodsite er blevet udnævnt til "Visiting Professor of Global Processes and Senior Research Fellow in Climate Strategy" ved Thunderbird School of Global Management, som har verdens højst rangerede MBA uddannelse inden for international handel....

  15. Beyond the techno-thriller: Michael Crichton and societal issues in science and technology

    OpenAIRE

    Stengler, E.

    2015-01-01

    Michael Crichton is primarily known for being an outstanding writer of techno-thrillers and co-creator of the genre. In this paper I suggest that his fictional works can and should be considered under the deeper and wider perspective of his concern for societal issues regarding science and technology with a profound consideration of their effects and on the life of people and the development of society.\\ud \\ud In fact this defining feature of his work is inclusive of numerous works by Michael...

  16. Copper-catalyzed asymmetric conjugate addition of organometallic reagents to extended Michael acceptors

    Directory of Open Access Journals (Sweden)

    Thibault E. Schmid

    2015-12-01

    Full Text Available The copper-catalyzed asymmetric conjugate addition (ACA of nucleophiles onto polyenic Michael acceptors represents an attractive and powerful methodology for the synthesis of relevant chiral molecules, as it enables in a straightforward manner the sequential generation of two or more stereogenic centers. In the last decade, various chiral copper-based catalysts were evaluated in combination with different nucleophiles and Michael acceptors, and have unambiguously demonstrated their usefulness in the control of the regio- and enantioselectivity of the addition. The aim of this review is to report recent breakthroughs achieved in this challenging field.

  17. A Greener, Efficient Approach to Michael Addition of Barbituric Acid to Nitroalkene in Aqueous Diethylamine Medium

    Directory of Open Access Journals (Sweden)

    Hany J. Al-Najjar

    2014-01-01

    Full Text Available An efficient method for the synthesis of a variety of pyrimidine derivatives 3a–t by reaction of barbituric acids 1a,b as Michael donor with nitroalkenes 2a–k as Michael acceptor using an aqueous medium and diethylamine is described. This 1,4-addition strategy offers several advantages, such as using an economic and environmentally benign reaction media, high yields, versatility, and shorter reaction times. The synthesized compounds were identified by 1H-NMR, 13C-NMR, CHN, IR, and MS. The structure of compound 3a was further confirmed by single crystal X-ray structure determination.

  18. 78 FR 6851 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Science.gov (United States)

    2013-01-31

    ... AFFAIRS Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program....'' SUPPLEMENTARY INFORMATION: Title: Patient Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form 10.... Abstract: VA Form 10-0476 will be used to gather feedback from patients regarding their satisfaction...

  19. 77 FR 69550 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Science.gov (United States)

    2012-11-19

    ... AFFAIRS Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program.... This notice solicits comments on information needed to determine patients' satisfaction with services... information technology. Title: Patient Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form...

  20. 76 FR 624 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Science.gov (United States)

    2011-01-05

    ... AFFAIRS Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program.... 2900-New (VA Form 10-0476).'' SUPPLEMENTARY INFORMATION: Title: Patient Satisfaction Survey Michael E... Review: New collection. Abstract: VA Form 10-0476 will be used to gather feedback from patients...

  1. Pyrrolidinyl-sulfamide derivatives as a new class of bifunctional organocatalysts for direct asymmetric Michael addition of cyclohexanone to nitroalkenes.

    Science.gov (United States)

    Chen, Jia-Rong; Fu, Liang; Zou, You-Quan; Chang, Ning-Jie; Rong, Jian; Xiao, Wen-Jing

    2011-07-21

    A series of chiral pyrrolidinyl-sulfamide derivatives have been identified as efficient bifunctional organocatalysts for the direct Michael addition of cyclohexanone to a wide range of nitroalkenes. The desired Michael adducts were obtained in high chemical yields and excellent stereoselectivities (up to 99/1 dr and 95% ee).

  2. Michael Shaffer, 6th July 1936 to 23rd March 2009: A heartfelt tribute

    Science.gov (United States)

    Mr. Michael Shaffer, Retired Pyraloidea Curator, at the Natural History Museum, London, England, passed away on March 23, 2009. He was an acknowledged world expert on Pyraloidea, a group of agriculturally important moths. He was curator of the largest Pyraloidea type collection in the world, and a...

  3. Michael Corleone's Destiny——From the perspective of interpersonal metafunction to analyze Godfather

    Institute of Scientific and Technical Information of China (English)

    胡爱洁

    2010-01-01

    Godfather is Maria Puzo's famous long story. Maria Puzo presented us the unknown Italians-American's life with underworld background. Although many comments from different perspectives have been made, few studies are made. with Halliday's framework. This paper is an attempt to study the destiny of Michael Corleone from the perspective of interpersonal metafunction in systemic functional linguistis.

  4. Training and Mastery of Techniques in Wittgenstein's Later Philosophy: A Response to Michael Luntley

    Science.gov (United States)

    Stickney, Jeff

    2008-01-01

    Responding to Michael Luntley's article, "Learning, Empowerment and Judgement," the author shows he cannot successfully make the following three moves: (1) dissolve the analytic distinction between learning by training and learning by reasoning, while advocating the latter; (2) diminish the role of training in Wittgenstein's philosophy, nor…

  5. Wolff-Michael Roth's passibility: at the limits of the constructivist metaphor: a book review

    Science.gov (United States)

    Brendel, Michelle

    2014-12-01

    Wolff-Michael Roth deconstructs the preeminent role conceded to constructivism in Science Education and demonstrates how we learn and know through pain, suffering, love or passion. This review explores his book "Passibility: At the Limits of the Constructivist Metaphor" through the eyes of an outsider to the world of science education.

  6. European Management: an emerging competitive advantage of European nations : A reply to Michael Porter

    NARCIS (Netherlands)

    F.A.J. van den Bosch (Frans); A.A. van Prooijen

    1992-01-01

    textabstractThis article extends the debate begun in the June 1992 issue of EMJ when the authors first criticized Michael Porter's explanatory framework in his Competitive Advantage of Nations (1990), over the role of national culture on the competitive advantage of nations. In this paper, Frans van

  7. Little Mosie from the Margaree: A Biography of Moses Michael Coady.

    Science.gov (United States)

    Welton, Michael R.

    This book examines the life of the Reverend Moses Michael Coady (1890-1959), a Roman Catholic priest who led the Antigonish Movement. During the Antigonish Movement, residents of the small maritime town of Antigonish, Nova Scotia, worked to achieve a nonviolent alternative to communism and fascism and to effect the social and economic…

  8. From Gouldner to Gramsci: The Making of Michael Apple's "Ideology and Curriculum"

    Science.gov (United States)

    Gottesman, Isaac

    2012-01-01

    Michael Apple's "Ideology and Curriculum", published in 1979, helped initiate a broad turn in the field of education in the United States to Marxist thought as a lens through which to analyze the relationship between school and society. This classic text continues to inform scholarship in the field. While "Ideology" has…

  9. Ytterbium triflate catalyzed Michael additions of beta-ketoesters in water

    NARCIS (Netherlands)

    Keller, E; Feringa, BL

    1996-01-01

    Michael addition of various beta-ketoesters towards enones and alpha,beta-unsaturated aldehydes resulted in a quantitative conversion to the corresponding 1,4-adducts by performing the reactions in water in the presence of ytterbium triflate as a water-tolerant Lewis acid.

  10. Highly efficient ytterbium triflate catalyzed Michael additions of alpha-nitroesters in water

    NARCIS (Netherlands)

    Keller, E; Feringa, B.L.

    Michael additions of alpha-nitroesters with enones and alpha,beta-unsaturated aldehydes result in quantitative conversions to the corresponding 1,4-adducts by performing the reactions in water in the presence of ytterbium triflate as water-tolerant Lewis acid.

  11. Novel chiral thioureas for highly enantioselective Michael reactions of malonates to nitroalkenes

    Institute of Scientific and Technical Information of China (English)

    Li Jun Yan; Quan Zhong Liu; Xue Lian Wang

    2009-01-01

    Highly efficient Michael addition reactions of malonates to nitroalkenes catalyzed by novel chiral thioureas derived from optically pure BINOL and amino acids are reported. Various trans-nitroalkenes reacted with malonates affording the desired products in up to 95% yield with excellent enantioselectivities (up to 97% ee).

  12. On the study of culture and mind: Interview with Prof. Michael Cole

    DEFF Research Database (Denmark)

    Glaveanu, Vlad Petre

    2011-01-01

    the two. And yet, as Professor Michael Cole and, more broadly, cultural psychologists would argue: there is no way of making sense of one if we disregard the other. Culture and mind constitute each other through action and communication and it is their intricate relationship that holds the key...

  13. European Management: an emerging competitive advantage of European nations : A reply to Michael Porter

    NARCIS (Netherlands)

    F.A.J. van den Bosch (Frans); A.A. van Prooijen

    1992-01-01

    textabstractThis article extends the debate begun in the June 1992 issue of EMJ when the authors first criticized Michael Porter's explanatory framework in his Competitive Advantage of Nations (1990), over the role of national culture on the competitive advantage of nations. In this paper, Frans van

  14. KF-Montmorillonite-catalyzed Michael Addition Reaction of Malononitrile to α,β-Unsaturated Ketones

    Institute of Scientific and Technical Information of China (English)

    SHI Daqing; WU Nan; ZHUANG Qiya

    2009-01-01

    The Michael addition reaction of α,β-unsaturated ketones with malononitrile catalyzed by KF-montmorillonite was investigated. It was interesting to note that at different reaction temperatures the addition and cycloaddition re-action products were obtained. This method has the advantages of good yields, mild reaction conditions, easy work-up and inexpensive reagents over the existing procedures.

  15. SYNTHESIS OF SOME PROLINE DERIVATIVES BY MEANS OF MICHAEL ADDITIONS OF GLYCINE ESTERS

    NARCIS (Netherlands)

    VANDERWERF, A; KELLOGG, RM

    1991-01-01

    Addition of the Schiff bases derived from reaction of glycine alkyl esters with benzophenoneimine to alpha,beta-unsaturated ketones, followed by hydrogenation of the addition products, leads to 5- or 3,5-substituted prolines. Hydrolysis of the Michael adducts rather than hydrogenation allows

  16. 78 FR 69661 - Michael Canales v. Edison International, EIX, Southern California Edison; Notice of Complaint

    Science.gov (United States)

    2013-11-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Michael Canales v. Edison International, EIX, Southern California Edison; Notice of Complaint Take notice that on November 11, 2013, pursuant to sections 205, 206, and 301 of the Federal Power Act (FPA), 16 U.S.C....

  17. Michael Eric Dyson: A Scholar and a Hip-Hop Preacher.

    Science.gov (United States)

    Fletcher, Michael A.

    2000-01-01

    Introduces Michael Eric Dyson, an African American man who grew up in the ghetto and eventually received a PhD from Princeton University. Today, he is a professor at DePaul University, the author of a radically revisionist new biography of Martin Luther King, Jr., a lecturer and talk show guest, a Baptist preacher, and a self-styled hip-hop…

  18. A Metal-Ligand Cooperative Pathway for Intermolecular Oxa-Michael Additions to Unsaturated Nitriles

    NARCIS (Netherlands)

    Perdriau, Sebastien; Zijlstra, Douwe S.; Heeres, Hero J.; de Vries, Johannes G.; Otten, Edwin

    2015-01-01

    An unprecedented catalytic pathway for oxa-Michael addition reactions of alcohols to unsaturated nitriles has been revealed using a PNN pincer ruthenium catalyst with a dearomatized pyridine backbone. The isolation of a catalytically competent Ru-dieneamido complex from the reaction between the Ru

  19. How to move things around a hospital: transport logistics at St. Michael's.

    Science.gov (United States)

    Yau, A; Zorn, R; McLaughlin, J

    1998-01-01

    Ongoing fiscal restraint challenges hospitals to focus their resources primarily on core services. Support services receive much less attention. This article describes the experience of Toronto's St. Michael's Hospital when it re-engineered its transport logistics by consolidating centralized support services into a logistics department and creating new roles and processes to enhance patient care.

  20. Moral Education and Education in Altruism: Two Replies to Michael Hand

    Science.gov (United States)

    White, John

    2016-01-01

    This article is a critical discussion of two recent papers by Michael Hand on moral education. The first is his "Towards a Theory of Moral Education", published in the "Journal of Philosophy of Education" in 2014 (Volume 48, Issue 4). The second is a chapter called "Beyond Moral Education?" in an edited book of new…

  1. The power of virtual integration: an interview with Dell Computer's Michael Dell. Interview by Joan Magretta.

    Science.gov (United States)

    Dell, M

    1998-01-01

    Michael Dell started his computer company in 1984 with a simple business insight. He could bypass the dealer channel through which personal computers were then being sold and sell directly to customers, building products to order. Dell's direct model eliminated the dealer's markup and the risks associated with carrying large inventories of finished goods. In this interview, Michael Dell provides a detailed description of how his company is pushing that business model one step further, toward what he calls virtual integration. Dell is using technology and information to blur the traditional boundaries in the value chain between suppliers, manufacturers, and customers. The individual pieces of Dell's strategy--customer focus, supplier partnerships, mass customization, just-in-time manufacturing--may be all be familiar. But Michael Dell's business insight into how to combine them is highly innovative. Direct relationships with customers create valuable information, which in turn allows the company to coordinate its entire value chain back through manufacturing to product design. Dell describes how his company has come to achieve this tight coordination without the "drag effect" of ownership. Dell reaps the advantages of being vertically integrated without incurring the costs, all the while achieving the focus, agility, and speed of a virtual organization. As envisioned by Michael Dell, virtual integration may well become a new organizational model for the information age.

  2. SYNTHESIS OF SOME PROLINE DERIVATIVES BY MEANS OF MICHAEL ADDITIONS OF GLYCINE ESTERS

    NARCIS (Netherlands)

    VANDERWERF, A; KELLOGG, RM

    1991-01-01

    Addition of the Schiff bases derived from reaction of glycine alkyl esters with benzophenoneimine to alpha,beta-unsaturated ketones, followed by hydrogenation of the addition products, leads to 5- or 3,5-substituted prolines. Hydrolysis of the Michael adducts rather than hydrogenation allows synthes

  3. "Raising Standards" or Reducing Aspirations and Opportunities Still Further? Michael Gove and Examination Reforms

    Science.gov (United States)

    Allen, Martin

    2013-01-01

    Well before the examinations grade crisis of 2012, Michael Gove had set out clear intentions for reforming public examinations. Though he claimed to be improving examinations and assessment by replicating practices that took place in high-performing countries and thus improving the ability of the UK economy to "compete", this…

  4. Noted astrophysicist Michael S. Turner to Head NSF'S mathematical and physical sciences directorate

    CERN Multimedia

    2003-01-01

    "The National Science Foundation has named celebrated astrophysicist Michael S. Turner of the University of Chicago as Assistant Director for Mathematical and Physical Sciences. He will head a $1 billion directorate that supports research in mathematics, physics, chemistry, materials and astronomy, as well as multidisciplinary programs and education" (1/2 page).

  5. Guanidinium Lactate Ionic Liquid:An Efficient and Recycling Catalyst for Michael Addition Reaction

    Institute of Scientific and Technical Information of China (English)

    LIANG Da-peng; XIN Xin; GAO Han; DUAN Hai-feng; LIN Ying-jie

    2009-01-01

    A facile and efficient 1,4-conjungate addition(Michael addition) reaction of active methylene compounds to a,β-unsaturated compounds,catalyzed by guanidinium lactate ionic liquid(IL9),has been developed.A range of chaicones and nitroaikenes together with active methylene compounds have been converted smoothly to the corresponding products in high yields.

  6. Synthesis of bicyclic guanidines via cascade hydroamination/Michael additions of mono-N-acryloylpropargylguanidines.

    Science.gov (United States)

    Kwon, Ki-Hyeok; Serrano, Catherine M; Koch, Michael; Barrows, Louis R; Looper, Ryan E

    2014-12-05

    A cascade silver(I)-catalyzed hydroamination/Michael addition sequence has been developed to deliver highly substituted bicyclic guanidines. This transformation gives rise to geometrically and constitutionally stable ene-guanidines and generates a remote stereocenter with moderate to high diastereoselectivity.

  7. Aza-Michael reaction of 12-N-carboxamide of (-)-cytisine under high pressure conditions.

    Science.gov (United States)

    Tsypysheva, Inna P; Lobov, Alexander N; Kovalskaya, Alena V; Petrova, Polina R; Ivanov, Sergey P; Rameev, Shamil A; Borisevich, Sophia S; Safiullin, Rustam L; Yunusov, Marat S

    2015-01-01

    The first example of aza-Michael reaction of 12-N-carboxamide of quinolizidine alkaloid (-)-cytisine with α,β-unsaturated ketones, dimethyl acetylenedicarboxylate and β-nitrostyrene under high pressure condition has been described. It has been shown that the [4+2]-cycloaddition takes place in the case with N-phenylmaleimide.

  8. Little Mosie from the Margaree: A Biography of Moses Michael Coady.

    Science.gov (United States)

    Welton, Michael R.

    This book examines the life of the Reverend Moses Michael Coady (1890-1959), a Roman Catholic priest who led the Antigonish Movement. During the Antigonish Movement, residents of the small maritime town of Antigonish, Nova Scotia, worked to achieve a nonviolent alternative to communism and fascism and to effect the social and economic…

  9. Hexafluorobenzene: A powerful solvent for a noncovalent stereoselective organocatalytic Michael addition reaction

    KAUST Repository

    Lattanzi, Alessandra

    2012-01-01

    A dramatic enhancement of the diastereo- and enantioselectivity in the nitro-Michael addition reaction organocatalysed by a commercially available α,α-l-diaryl prolinol was disclosed when performing the reaction in unconventional hexafluorobenzene as a medium. DFT calculations were performed to clarify the origin of stereoselectivity and the role of C 6F 6. © The Royal Society of Chemistry 2012.

  10. Michael Pressley's Contributions to the History and Future of Strategies Research

    Science.gov (United States)

    Harris, Karen R.; Alexander, Patricia; Graham, Steve

    2008-01-01

    The history of strategies research during the past quarter century has been a story of significant conceptualizations and reconceptualizations regarding the nature, development, and teaching of cognitive and metacognitive strategies. Theoretical models, empirical research, and discussions contributed by Michael Pressley have been central to…

  11. Outside in America: George Michael's music video, public sex and global pop culture

    NARCIS (Netherlands)

    Kooijman, J.

    2004-01-01

    Six months after his controversial arrest for ‘lewd conduct’ at a men’s public restroom in Beverly Hills, British pop star George Michael released the song and music video ‘Outside’ which can be seen as an explicit commentary on the controversy. In this article, I read the music video in three ways:

  12. Vice Premier Zeng Peiyan Meets with Michael Cohrs, CEO of Corporate & Investment Banking of Deutsche Bank

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正>Invited by the CPAFFC, Michael Cohrs, Chief Executive Officer of the Corporate and Investment Banking of Deutsche Bank, visited Beijing from February 26 to 28, 2004. Vice Premier Zeng Peiyan of the State Council met with Cohrs and his party. Deutsche Bank AG, a global multipurpose bank

  13. Gender Relations and Sexual Harassment in the Workplace: Michael Crichton's "Disclosure" as a Teaching Tool.

    Science.gov (United States)

    Comer, Debra R.; Cooper, Elizabeth A.

    1998-01-01

    Describes how to use Michael Crichton's novel "Disclosure" and the film based on it for class discussions of such issues as what constitutes sexual harassment, harassment of men, relationship between sexual harassment and power, organizational responses to harassment, and gender differences in career advancement tactics. (SK)

  14. Briti ekspert : euroliidus kaob Eestist tööpuudus / Michael Richardson ; interv. Airi Ilisson

    Index Scriptorium Estoniae

    Richardson, Michael

    2003-01-01

    Eestis Suurbritannia tööreformi tutvustava töö- ja sotsiaalnõuniku sõnul on Suurbritannias peaaegu kadunud pikaajaline töötus noorte hulgas, vanematest inimestest on vaid üksikud tööta kauem kui aasta. Vt. samas: Kes on Michael Richardson?

  15. Michael Peters' Lyotardian Account of Postmodernism and Education: Some Epistemic Problems and Naturalistic Solutions

    Science.gov (United States)

    Clark, John A.

    2006-01-01

    Postmodernism has established a significant hold in educational thought and some of the most important ideas are to be found in the writings of Michael Peters. This paper examines his postmodern stance and use of Lyotard's account of knowledge, and from a naturalist point of view raises a number of objections centred on science as a metanarrative,…

  16. Schools as "Poetry-Friendly Places": Michael Rosen on Poetry in the Curriculum

    Science.gov (United States)

    Xerri, Daniel

    2014-01-01

    This article explores the views of children's poet Michael Rosen in relation to poetry in education. It is based on an interview in which Rosen not only discusses the significance of encouraging young people to engage with poetry at school but also analyzes a number of threats to poetry's place in the English curriculum. This article identifies…

  17. Training and Mastery of Techniques in Wittgenstein's Later Philosophy: A Response to Michael Luntley

    Science.gov (United States)

    Stickney, Jeff

    2008-01-01

    Responding to Michael Luntley's article, "Learning, Empowerment and Judgement," the author shows he cannot successfully make the following three moves: (1) dissolve the analytic distinction between learning by training and learning by reasoning, while advocating the latter; (2) diminish the role of training in Wittgenstein's philosophy, nor…

  18. Subjectivity and Cultural Adjustment in Mathematics Education: A Response to Wolff-Michael Roth

    Science.gov (United States)

    Brown, Tony

    2012-01-01

    In this volume, Wolff-Michael Roth provides a critical but partial reading of Tony Brown's book "Mathematics Education and Subjectivity". The reading contrasts Brown's approach with Roth's own conception of subjectivity as derived from the work of Vygotsky, in which Roth aims to "reunite" psychology and sociology. Brown's book, however, focuses on…

  19. Enzymatic carbon-carbon bond-forming Michael-type additions

    NARCIS (Netherlands)

    Geertsema, Edzard; Poelarends, Gerrit; Faber, Kurt; Fessner, Wolf-Dieter; Turner, Nicholas

    2014-01-01

    This chapter gives an overview of practical biocatalytic procedures for C-C bond-forming Michael(-type) additions suitable for organic synthesis purposes. Reported product yields, workup and isolation methods, stereoselectivity, and availability of the applied enzymes are assessed. All methodologies

  20. Kunstlik viljastamine - kas rahva püsimajäämise võti? / Michael Cook

    Index Scriptorium Estoniae

    Cook, Michael

    2007-01-01

    Kunstlikust viljastamisest pole üksi abi - vaid siis, kui noored mehed ja naised pööravad selja tarbimiskultusele ja individualismile, hakkab sündimus tõusma taastootmisest kõrgemale, kirjutab BioEdge toimetaja Michael Cook

  1. The Educational Philosophies of Mordecai Kaplan and Michael Rosenak: Surprising Similarities and Illuminating Differences

    Science.gov (United States)

    Schein, Jeffrey; Caplan, Eric

    2014-01-01

    The thoughts of Mordecai Kaplan and Michael Rosenak present surprising commonalities as well as illuminating differences. Similarities include the perception that Judaism and Jewish education are in crisis, the belief that Jewish peoplehood must include commitment to meaningful content, the need for teachers to teach from a position of…

  2. Michael Perelman: An ecological future in view of Marxist Economics (Ⅱ)

    Institute of Scientific and Technical Information of China (English)

    Ren Xiaomei

    2009-01-01

    @@ Interviewee profile: Michael Perelman, currently professor of Economics Department of California State University, USA, American economist and economic historian with nearly 20 publications in the field of economics criticism, including Railroading Economics, Manufacturing Discontent, The Perverse Economy, and The Invention of Capitalism.

  3. Neuroscientific Investigator of High Mathematical Ability: An Interview with Michael W. O'Boyle

    Science.gov (United States)

    Kalbfleisch, M. Layne

    2008-01-01

    This article presents an interview with Michael W. O'Boyle, a neuroscientific investigator of high mathematical ability. O'Boyle is a professor in the Department of Human Development and Family Studies, Texas Tech University, and Adjunct Professor of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center.…

  4. A tribute to Michael R. Raupach for contributions to aeolian fluid dynamics

    Science.gov (United States)

    Since the early work of Bagnold in the 1940s, aeolian research has grown to become a major integral part of earth-system studies. Many individuals have contributed to this development, and Dr. Michael R. Raupach (MR2, 1950 – 2015) was one of the most outstanding. MR2 worked for about a decade (1985 ...

  5. Synthesis of β3-Amino Acids via Catalyst- and Solvent-Free Aza-Michael Reaction

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A safe, environmentally friendly and cost-effective method for the synthesis of β-amino acid derivatives has been developed. Treatment of α,β-unsaturated compounds with aliphatic amines furnishes β-amino acid derivatives in good to excellent yields via a catalyst- and solvent-free aza-Michael addition.

  6. What Work Do the Concepts of "Language" and "Literature" Do for Michael Rosenak?

    Science.gov (United States)

    Levisohn, Jon A.

    2014-01-01

    Michael Rosenak uses the twin metaphors of "language" and "literature," borrowed from Oakeshott and Peters, to argue that the goal of education is initiation into a language. This goal transcends the study of literature in that language. It includes, as well, the development of the capacity both to critique literature and to…

  7. Book Review of "The Molecular Biology of Cancer" by Stella Pelengaris, Michael Khan (Editors

    Directory of Open Access Journals (Sweden)

    Schmidt Christian

    2007-11-01

    Full Text Available Abstract Here, a review of "The Molecular Biology of Cancer" (Stella Pelengaris and Michael Khan [Editors] is given. The detailed description of the book is provided here: Pelengaris S, Khan M (Eds: The Molecular Biology of Cancer; Blackwell Publishing, Oxford (U.K.; 2006. 531 pages, 214 illustrations, ISBN 9-78140-511-814-9, £31.99.

  8. Highly efficient ytterbium triflate catalyzed Michael additions of alpha-nitroesters in water

    NARCIS (Netherlands)

    Keller, E; Feringa, B.L.

    1997-01-01

    Michael additions of alpha-nitroesters with enones and alpha,beta-unsaturated aldehydes result in quantitative conversions to the corresponding 1,4-adducts by performing the reactions in water in the presence of ytterbium triflate as water-tolerant Lewis acid.

  9. Outside in America: George Michael's music video, public sex and global pop culture

    NARCIS (Netherlands)

    Kooijman, J.

    2004-01-01

    Six months after his controversial arrest for ‘lewd conduct’ at a men’s public restroom in Beverly Hills, British pop star George Michael released the song and music video ‘Outside’ which can be seen as an explicit commentary on the controversy. In this article, I read the music video in three ways:

  10. Michael Faraday on the Learning of Science and Attitudes of Mind.

    Science.gov (United States)

    Crawford, Elspeth

    1998-01-01

    Makes use of Michael Faraday's ideas on learning, focusing on his attitudes toward the unknowns of science and the development of an attitude that improves scientific decision making. This approach acknowledges that there is an inner struggle involved in facing unknowns. (DDR)

  11. Comment on “Geochemistry of buried river sediments from Ghaggar Plains, NW India: Multi-proxy records of variations in provenance, paleoclimate, and paleovegetation patterns in the late quaternary” by Ajit Singh, Debajyoti Paul, Rajiv Sinha, Kristina J. Thomsen, Sanjeev Gupta

    Science.gov (United States)

    Clift, Peter D.; Giosan, Liviu; East, Amy E.

    2016-01-01

    Singh et al. (2016) published a geochemical record of sediment compositions from the flood plain of the Ghaggar River in western India and use the changing provenance, particularly as traced by Nd isotope composition, to reconstruct how erosion patterns have changed over the past 100 k.y. In doing so they propose a link between climate change and erosion, and they argue for more erosion from the Higher Himalaya during warmer interglacial periods and more from the Lesser Himalaya during glacial intervals. While we support the concept of erosion patterns being climatically modulated we here take the opportunity to compare the data presented by Singh et al. (2016) to relevant published records within the region greater Ghaggar region and to open a balanced discussion on how climate and erosion are coupled in the western Himalaya.

  12. Pseudangularia gonzalezi n. sp. and Gibsonilepis swifti (Singh, 1952) n. g., n. comb. (Cestoda, Dilepididae) from the House Swift, Apus affinis (J.E. Gray) (Aves, Apodiformes) from Franceville, Republic of Gabon.

    Science.gov (United States)

    Dimitrova, Yana D; Mariaux, Jean; Georgiev, Boyko B

    2013-11-01

    Nine specimens of Apus affinis (J.E. Gray) were studied at Franceville, Haut-Ogooué Province, Republic of Gabon, for the presence of helminth parasites. Two cestode species of the family Dilepididae were recorded. Pseudangularia gonzalezi n. sp. is distinguished from the most similar species P. europaea Georgiev & Murai, 1993 by having elliptical cirrus-sac, longer vagina, longer rostellar sheath and greater diameter of suckers. An identification key to the species of the genus Pseudangularia Burt, 1938 is proposed. The present study is the first record of the genus Pseudangularia in the Afrotropical Region. Our study confirms that, in dilepidids with vaginal sclerites from swifts, breaking off the cirrus after copulation is a frequent phenomenon. The genus Gibsonilepis n. g. is erected as monotypic for Vitta swifti Singh, 1952 (originally described from the same host species in India) and Gibsonilepis swifti n. comb. is proposed. Gibsonilepis n. g. is distinguished from Vitta Burt, 1938 by its highly elongate rostellum, rostellar sheath much bigger than rostellum, relatively small rostellar hooks possessing strongly developed guard, disc-shaped suckers with weak peripheral musculature and flat or convex central part, long and well-expressed neck, highly lobed two-winged ovary (lobes rounded) and presence of a band consisting of rows of spine-like microtriches along posterior margin of each proglottis. This is the first record of G. swifti in the Afrotropical Region. The separation of G. swifti from the genus Vitta (parasites of swallows) suggests that, contrary to previous opinions, no dilepidid genera are shared by Apodidae (swifts) and Hirundinidae (swallows).

  13. Novel Ionic Liquid with Both Lewis and Brønsted Acid Sites for Michael Addition

    Directory of Open Access Journals (Sweden)

    Runpu Shen

    2011-10-01

    Full Text Available Ionic liquid with both Lewis and Brønsted acid sites has been synthesized and its catalytic activities for Michael addition were carefully studied. The novel ionic liquid was stable to water and could be used in aqueous solution. The molar ratio of the Lewis and Brønsted acid sites could be adjusted to match different reactions. The results showed that the novel ionic liquid was very efficient for Michael addition with good to excellent yields within several min. Operational simplicity, high stability to water and air, small amount used, low cost of the catalyst used, high yields, chemoselectivity, applicability to large-scale reactions and reusability are the key features of this methodology, which indicated that this novel ionic liquid also holds great potential for environmentally friendly processes.

  14. Sir Michael Francis Addison Woodruff (1911-2001) FRS DSc MD MS FRCS.

    Science.gov (United States)

    Leigh, Winston

    2011-02-01

    Michael Woodruff performed the first successful renal transplant in the UK and described the technique of joining the ureter of the transplant to the bladder. He contributed to all aspects of transplantation biology and was responsible for the design of the first purpose-built transplant unit in the world. As a Japanese prisoner of war at Changi in Singapore, Michael Woodruff studied the effects of malnutrition and devised a machine for extracting vitamins and trace elements from grass. After the war he demonstrated that the anterior chamber of the eye was an immunologically privileged site. He was the first person to describe 'adaptation'. He showed that antilymphocytic serum was effective as an immunosuppressive agent for homografts.

  15. An Analysis of Michael Long's Interaction Hypothesis in Second Language Acquisition

    Institute of Scientific and Technical Information of China (English)

    单映

    2009-01-01

    The Interaction Hypothesis,which was first advanced by Michael Long,is considered ag a further supplement or extension of the Input Hypothesis in the field of second language acquisition.This paper explains the main claims of Michael Long'8 Interaction Hypothesis,the three steps to study how input and interaction affect the acquisition of a second language,and the importance of the interactional modifications applied by both participants of the interaction.Emphasis is placed on the evaluation of the theory as well as its relation to second language teaching,with many researchers'findings and arguments discussed as supporting evidence.It aims to help the effective application of this theory in second language teaching.

  16. Interviews with Michael Baxandall, February 3rd and 4th, 1994, Berkeley, CA

    Directory of Open Access Journals (Sweden)

    Allan Langdale

    2009-12-01

    Full Text Available The following interviews with Michael Baxandall were conducted in Berkeley on February 3rd and 4th of 1994. The content of these interviews include general responses about developments in art history in the years between 1960 and 1985, a period of dramatic modifications in the discipline. Among the issues are the rise of the social history of art and the sources from anthropology that informed Baxandall’s concept of the ‘Period Eye’. Baxandall talks about his own work, his personal intellectual history, and the scholars of past and current generations who influenced him. Other topics include Baxandall’s professional trajectory, the Warburg Library, and aspects of cultural history having to do with Renaissance Humanism. These interviews first appeared as an appendix to the PhD dissertation by Allan Langdale, Art History and Intellectual History: Michael Baxandall’s Work between 1963 and 1985, U. C. Santa Barbara, 1995.

  17. [An exceptional human relationship (Michael P. Kierkegaard, Søren Kierkegaard)].

    Science.gov (United States)

    Jacobs, R

    1978-01-01

    There were a father and a son, Michael and Sören Kierkegaard, both highly talented, imaginitive, witty, humorous, especially interested in shrewd dialectrical dialogues respectively debates, both profound melancholy ponderers. But according to very own individuality their congeniality wasn't absolute. The father, being under a questionable rigorous opinion of sin, suffered from undeserved divine grace since early childhood. And Michael Kierkegaard made Sören anxious with the religious experience of original sin. This anxiety moved (touched or affected) the sensitive son mighty. Nevertheless he should not despair hopelessly like his unlucky father. On the contrary: Sørens incomparable melancholy, mental agony and anxiety (fear or anguish) forced the faith, existing independently of them, in a radical refining. That is why Sören Kierkegaard succeeded in sublimation of all psychological and philosophic (al) attitudes (or opinions) in the sphere of religiousness. And the result? A novel philosophy of life: Christian existentialism.

  18. Michael K. Scullin: Psi Chi/APA Edwin B. Newman Graduate Research Award.

    Science.gov (United States)

    2011-11-01

    Presents Michael K. Scullin as the 2011 winner of the American Psychological Association Psi Chi/APA Edwin B. Newman Graduate Research Award. "For an outstanding research paper that examines the relationship between prospective memory in executing a goal and various lapses of time from 20 minutes up to a 12- hour wake delay and a 12-hour sleep delay. The results suggest that consolidation processes active during sleep increase the probability of goal execution. The paper, titled 'Remembering to Execute a Goal: Sleep On It!' was published in Psychological Science in 2010 and was the basis for Michael K. Scullin's selection as the recipient of the 2011 Psi Chi/APA Edwin B. Newman Graduate Research Award. Mark A. McDaniel, PhD, served as faculty research advisor." (PsycINFO Database Record (c) 2011 APA, all rights reserved). 2011 APA, all rights reserved

  19. Navigating Transition: Freedom, Limitation and the Post-colonial Persona in Michael Ondaatje's The Cat's Table

    Directory of Open Access Journals (Sweden)

    Alaa Alghamdi

    2012-11-01

    Full Text Available Michael Ondaatje's 2011 novel The Cat's Table follows a young boy's voyage from Colombo, Sri Lanka to London, England. Through this character and the unique environment of the ship, which forms a compelling sense of transitory place, Ondaatje explores liminality and its relationship with limitations or barriers. The young protagonist, Michael, and his companions enjoy an unusual level of freedom aboard the contained and hierarchically segmented ship. Polarization and transition between Eastern and Western culture is present but pales in importance compared to the validation of the self that is located within and defined by the sense of the in-between, an essential rite of passage undertaken before re-joining society.

  20. An Integral Part of the Frederick Community—Michael Dean | Poster

    Science.gov (United States)

    For more than 30 years, Michael Dean, Ph.D., has been an integral part of the NCI at Frederick community. In addition to studying several different aspects of genomics and cancer research, he has worked with the Werner H. Kirsten Student Intern Program and also volunteered his time with Mission of Mercy, a community-based organization providing free healthcare and free prescription medications to the uninsured and under-insured.

  1. Highlighting High Performance: Michael E. Capuano Early Childhood Center; Somerville, Massachusetts

    Energy Technology Data Exchange (ETDEWEB)

    2006-03-01

    This brochure describes the key high-performance building features of the Michael E. Capuano Early Childhood Center. The brochure was paid for by the Massachusetts Technology Collaborative as part of their Green Schools Initiative. High-performance features described are daylighting and energy-efficient lighting, indoor air quality, solar and wind energy, building envelope, heating and cooling systems, water conservation, and acoustics. Energy cost savings are also discussed.

  2. Is there sexism?——Feminist discourse analysis of the recruitment advertisement of Michael Page

    Institute of Scientific and Technical Information of China (English)

    段绘宇

    2010-01-01

    Sexism can be discovered in every sector oftbe society although it is under different guises. Women as a whole are treated oppressively and differently from men and they are subject to personal and institutional discrimination. This paper reveals sexism common in the business world through analyzing the register of tbe recruitment advert of'Michael Page' in 'Financial World' to raise critical gender awareness of the readers so that true equality between men and women can be eventually realized in the world.

  3. Horror movie aspects and experimentation in Michael Jackson’s Thriller music video

    OpenAIRE

    Vargas, Herom; Universidade Municipal de São Caetano do Sul - USCS; Gonçalves, Rafael; Universidade Municipal de São Caetano do Sul - USCS

    2016-01-01

    This article analyzes the use of elements from the horror fi lm genre in the music video Thriller (1982), by Michael Jackson, as experimentation within the field of pop music. Based on the semiotics of culture, grounded on the concepts of cultural text, semiosphere, border and modeling, developed by Iuri Lotman, the analysis identified innovations in the use of horror as humor and, in the music, modeling of creatures, moving among horror, the fantastic and the reality.Keywords: horror, music ...

  4. Efficient Lewis Acids Catalyzed Aza-Michael Reactions of Enones with Carbamates

    Institute of Scientific and Technical Information of China (English)

    XIA Chun-Gu; XU Li-Wen

    2004-01-01

    The a-amino carbonyl functionality is not only a segment of biologically important natural products but also a versatile intermediate for the synthesis of nitrogen-containing compounds.1 The development of novel synthetic methods leading to a-amino ketone, a-amino acids or their derivatives has attracted much attention in organic synthesis.2 Among the traditional methods for generating a-amino carbonyl compounds, Mannich-type reaction is one of the classical and powerful methods.3 However, the classic Mannich reaction presents serious disadvantages, for example, there is still a drawback in that the silyl enolates have to be prepared from the corresponding carbonyl compounds. Alternatively, aza-Michael additions can be used to create carbon-heteroatom bonds by reaction of a,a-unsaturated carbonyl compounds with amines. Although recent advances have made this route more attractive, development of cheaper, simpler, and more efficient metal catalyst, especially which can be applied to chalcone, is highly desirable.In this paper, we demonstrated that the first aza-Michael reaction of chalcone with a less nucleophilic carbamates can be accomplished on Me3SiCFFeCl3 catalyst system under very mild conditions. Apart from experimental simplicity, the advantages of this methodology are the use of a very cheap Lewis acid catalyst and the insensitivity of the reaction mixture towards air and moisture.catalyst for aza-Michael reaction of chalcone and cyclic enones with carbamates. And with the cyclic enones with carbamates in dichloromethane at room temperature were also investigated. In this conjugate addition reaction, good to excellent yields of a-amino ketones were obtained with system could also mediates aza-Michael addition of carbamates to chalcone and derivatives.These new strategies opened efficient procedures for the synthesis of a-amino ketones under mild conditions.

  5. Asymmetric Synthesis of Fully Substituted Cyclopentane-Oxindoles through an Organocatalytic Triple Michael Domino Reaction

    Science.gov (United States)

    Zou, Liang-Hua; Philipps, Arne R; Raabe, Gerhard; Enders, Dieter

    2015-01-01

    An efficient, highly stereoselective asymmetric synthesis of fully functionalized cyclopentanes bearing an oxindole moiety and several other functional groups in one pot has been developed. Key step is an organocatalytic triple Michael domino reaction forming three C–C bonds and six stereocenters, including a quaternary one. Starting from equimolar amounts of simple substrates, a high molecular complexity can be reached after a Wittig olefination in one pot. The new protocol can easily be scaled up to gram amounts. PMID:25470781

  6. Tetramethylguanidium Lactate Ionic Liquid:Catalyst-free Medium for Michael Addition Reaction

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A catalyst-free, facile and efficient Michael addition reaction of active methylene compounds as well as nitromethane with chalcones catalyzed by guanidinium lactate ionic liquid was done. A series of chalcones,nitromethane, and active methylene compounds were converted smoothly to the corresponding products in high yields.The simple procedure, very mild conditions, high yields, and reuse of the IL without any loss of catalytic activity make this protocol considerably attractive for academic researches and practical applications.

  7. Catalytic enantioselective Michael addition reactions of alpha-nitroesters to alpha,beta-unsaturated ketones

    NARCIS (Netherlands)

    Keller, E; Veldman, N; Spek, AL; Feringa, BL

    1997-01-01

    Enantioselective Michael additions of alpha-nitroesters 2a-d with alpha,beta-unsaturated ketones were carried out in the presence of a catalytic amount of chiral Al-Li-(R,R')-2,2'-dihydroxy-1,1'-binaphthyl ('AlLiBINOL') complex prepared in situ from LiAlH4 and 2.45 equiv. of (R,R')-BINOL. The enanti

  8. Catalytic enantioselective Michael addition reactions of α-nitroesters to α,β-unsaturated ketones

    NARCIS (Netherlands)

    Keller, Erik; Veldman, Nora; Spek, Anthony L.; Feringa, Bernard

    1997-01-01

    Enantioselective Michael additions of α-nitroesters 2a-d with α,β-unsaturated ketones were carried out in the presence of a catalytic amount of chiral Al-Li-(R,R')-2,2'-dihydroxy-1,1'-binaphthyl (‘AlLiBINOL’) complex prepared in situ from LiAlH4 and 2.45 equiv. of (R,R')-BINOL. The enantioselectivit

  9. Functionalized 3D Architected Materials via Thiol-Michael Addition and Two-Photon Lithography.

    Science.gov (United States)

    Yee, Daryl W; Schulz, Michael D; Grubbs, Robert H; Greer, Julia R

    2017-04-01

    Fabrication of functionalized 3D architected materials is achieved by a facile method using functionalized acrylates synthesized via thiol-Michael addition, which are then polymerized using two-photon lithography. A wide variety of functional groups can be attached, from Boc-protected amines to fluoroalkanes. Modification of surface wetting properties and conjugation with fluorescent tags are demonstrated to highlight the potential applications of this technique. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Feeding Health: Michael Pollan on Improving Public Health through the Food Systems

    Centers for Disease Control (CDC) Podcasts

    2009-08-19

    In this podcast, author Michael Pollan discusses his March 2009 visit to CDC and offers his thoughts on the intersection between the government, the food systems, and public health.  Created: 8/19/2009 by National Center for Environmental Health (NCEH), National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Office of Sustainability.   Date Released: 4/15/2010.

  11. N-1 regioselective Michael-type addition of 5-substituted uracils to (2-hydroxyethyl acrylate

    Directory of Open Access Journals (Sweden)

    Walczak Krzysztof Z

    2007-11-01

    Full Text Available Abstract N-1 regioselective Michael-type addition of 5-substituted uracils to (2-hydroxyethyl acrylate is presented. The reactions were performed in polar aprotic solvents and with avoidance of polymerization of acrylic substrate. The obtained adducts may serve as versatile substrates for further functionalization, e.g. into (3-uracil-1-ylpropanoic acids or transformations, with participation of hydroxyl group, into ester-conjugated acyclic nucleosides.

  12. Remote Sensing of Sea Surface Wind of Hurricane Michael by GPS Reflected Signals

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    In this paper, the propagating geometry and the waveform of the GPS reflected signals are expatiated in detail. Furthermore, the principle and the method of retrieving sea surface wind are presented. In order to test the feasibility of retrieval, the experiment data obtained by NASA in Hurricane Michael are used. The result shows that the retrieval accuracy of wind speed is about 2 m/s.

  13. Translation of Michael Sadowsky's paper "The differential equations of the M\\"obius band"

    CERN Document Server

    Hinz, Denis F

    2014-01-01

    This article is a translation of Michael Sadowsky's original paper "Die Differentialgleichungen des M\\"obiusschen Bandes." in Jahresbericht der Deutschen Mathermatiker-Vereinigung 39 (2. Abt. Heft 5/8, Jahresversammlung vom 16. bis 23. September), 49-51 (1929), which is a short version of his paper "Theorie der elastisch biegsamen undehnbaren B\\"ander mit Anwendungen auf das M\\"obiussche Band" in 3. internationaler Kongress f\\"ur technische Mechanik, Stockholm, 1930.

  14. An Integral Part of the Frederick Community—Michael Dean | Poster

    Science.gov (United States)

    For more than 30 years, Michael Dean, Ph.D., has been an integral part of the NCI at Frederick community. In addition to studying several different aspects of genomics and cancer research, he has worked with the Werner H. Kirsten Student Intern Program and also volunteered his time with Mission of Mercy, a community-based organization providing free healthcare and free prescription medications to the uninsured and under-insured.

  15. Monetary Regimes and Policy on a Global Scale: The Oeuvre of Michael D. Bordo

    OpenAIRE

    Rockoff, Hugh; Eugene N. White

    2012-01-01

    Michael D. Bordo has helped to define the modern field of monetary history, drawing from it important policy lessons for current practitioners. For his seventieth year, we survey his contributions to our understanding of the Great Depression, money and the economy in historical perspective, exchange rate regimes including the gold standard, Bretton Woods, and the European Monetary Union, globalization, financial crises, the Canadian monetary experience, and historical guidance for monetary p...

  16. Organocatalytic Asymmetric Michael Addition of 4-Hydroxycoumarin to β,γ-Unsaturated α-Keto Esters

    Energy Technology Data Exchange (ETDEWEB)

    Suh, Chang Won; Han, Tae Hyun; Kim, Dae Young [Soonchunhyang Univ., Asan (Korea, Republic of)

    2013-06-15

    In conclusion, we have developed organocatalytic enantioselective conjugate addition reaction of 4-hydroxycoumarin (1) to β,γ-unsaturated α-keto esters 2 to afford biologically valuable warfarin derivatives 3. The process is efficiently catalyzed by a binaphthyl-modified thiourea organocatalyst. The coumarin core is present as a characteristic structural motif in a large number of natural products and biologically active molecules.1 Particularly, many of these naturally occurring 4-hydroxycoumarin and their synthetic analogues are important precursors for the synthesis of natural products and pharmaceuticals. Enantioselective organocatalytic conjugate addition of 4-hydroxycoumarin to α,β-unsaturated ketones is a straightforward method to access warfarin which is an effective anticoagulants. Although a number of reactions of α,β-unsaturated ketones as Michael acceptors have been reported, the corresponding β,γ-unsaturated α-keto esters have received relatively little attention as Michael acceptors. Recently, several groups have reported the asymmetric Michael addition of 4-hydroxycoumarin to β,γ-unsaturated α-keto esters catalyzed by Cu(II)-bisoxazoline, N,N'-dioxide-Ni(II) complexes, thiourea catalysts. Although several efficient methods have been achieved by these systems, an effective method for the synthesis of warfarin analogues is still a challenge.

  17. En memoria de Michael Jiménez (1948-2001

    Directory of Open Access Journals (Sweden)

    Mauricio Archila Neira

    2010-08-01

    Full Text Available El 1 de septiembre de 2001 murió el historiador Michael Jiménez. Su apellido provenía de España de donde emigró su abuelo en busca de mejor suerte al otro lado del Atlántico. Nacido en el pequeño pueblo de Merced, California (Estados Unidos en agosto de 1948 en el seno de una familia obrera, Michael vivió su infancia en Colombia. A fines de ese año, su padre se desplazó a estas tierras para ser funcionario de la Texas, una multinacional petrolera que tenía sus reales en Puerto Boyacá. Michael estudió en el colegio Nueva Granada -becado por la Texas- hasta los catorce años. En dicho colegio fue compañero de pupitre de Herbert Braun, descendiente a su vez de una familia de emigrantes a Colombia, y con quien la vida lo juntaría de nuevo en las tierras del norte y en oficios similares.

  18. TDDFT Study on Different Sensing Mechanisms of Similar Cyanide Sensors Based on Michael Addition Reaction

    Institute of Scientific and Technical Information of China (English)

    Guang-yue Li; Ping Song; Guo-zhong He

    2011-01-01

    The solvents and substituents of two similar fluorescent sensors for cyanide, 7-diethylamino-3-formylcoumarin (sensor a) and 7-diethylamino-3-(2-nitrovinyl)coumarin (sensor b), are proposed to account for their distinct sensing mechanisms and experimental phenomena.The time-dependent density functional theory has been applied to investigate the ground states and the first singlet excited electronic states of the sensor as well as their possible Michael reaction products with cyanide, with a view to monitoring their geometries and photophysical properties. The theoretical study indicates that the protic water solvent could lead to final Michael addition product of sensor a in the ground state, while the aprotic acetonitrile solvent could lead to carbanion as the final product of sensor b. Furthermore,the Michael reaction product of sensor a has been proved to have a torsion structure in its first singlet excited state. Correspondingly, sensor b also has a torsion structure around the nitrovinyl moiety in its first singlet excited state, while not in its carbanion structure. This could explain the observed strong fluorescence for sensor a and the quenching fluorescencefor the sensor b upon the addition of the cyanide anions in the relevant sensing mechanisms.

  19. Michael addition reactions of cyclanones with acrylamides: Producing 2-carbamoylethyl derivatives or ene-lactams

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The electron-withdrawing groups (EWGs) in the electrophilic alkenes employed in the Michael addition reaction are almost only CO2R, CN, COR, NO2, and SO2Ph. Although amides (CONR1R2) are also typical electron-withdrawing groups and are of great importance in organic synthesis, they are scarcely em-ployed as the EWGs of the electrophilic alkenes in the Michael addition reaction. In this work, the Mi-chael reactions of acrylamide and its derivatives with cyclanones were successfully carried out in the presence of enough radical inhibitors. The amide groups play a key role in producing the preferred products. The N-substituted acrylamides, including N-monosubstituted and N,N-disubstituted acryla-mides could react with cyclohexanone (CHn) to give the expected 2-carbamoylethyl derivatives; how-ever, acrylamide reacting with cyclohexanone only produced ene-lactam. Cyclanones also have effects on the products, while the ring size of cyclanones influences the reaction yield and the α-substituent decides the ratio of resulting isomeric ene-lactams.

  20. En memoria de Michael Jiménez (1948-2001

    Directory of Open Access Journals (Sweden)

    Mauricio Archila Neira

    2001-01-01

    Full Text Available El 1 de septiembre de 2001 murió el historiador Michael Jiménez. Su apellido provenía de España de donde emigró su abuelo en busca de mejor suerte al otro lado del Atlántico. Nacido en el pequeño pueblo de Merced, California (Estados Unidos en agosto de 1948 en el seno de una familia obrera, Michael vivió su infancia en Colombia. A fines de ese año, su padre se desplazó a estas tierras para ser funcionario de la Texas, una multinacional petrolera que tenía sus reales en Puerto Boyacá. Michael estudió en el colegio Nueva Granada -becado por la Texas- hasta los catorce años. En dicho colegio fue compañero de pupitre de Herbert Braun, descendiente a su vez de una familia de emigrantes a Colombia, y con quien la vida lo juntaría de nuevo en las tierras del norte y en oficios similares.

  1. Tagasipöördumine esteetika juurde = Return to aesthetics / Keith Moxey, Michael Ann Holly ; interv. Anu Allas

    Index Scriptorium Estoniae

    Moxey, Keith

    2007-01-01

    Ameerika kunstiajaloolased Keith Moxey ning Michael Ann Holly tutvustavad uut lähenemist kunstiajaloole (new art history). Nn. naasmine esteetika juurde tähendab püüet integreerida kunstiajalukku ja -teooriasse uuesti ja tugevamalt kunstiteos

  2. Tandem Knoevenagel–Michael reactions in aqueous diethylamine medium: A greener and efficient approach toward bis-dimedone derivatives

    Directory of Open Access Journals (Sweden)

    Abdullah Mohammed Al-Majid

    2017-02-01

    The use of inexpensive, eco-friendly and readily available reagents, easy work-up, and high purity products makes the procedure a convenient and robust method for the synthesis of tandem Knoevenagel–Michael adducts.

  3. Vice Premier Zeng Peiyan Meets with Michael Cohrs,CEO of Corporate & Investment Banking of Deutsche Bank

    Institute of Scientific and Technical Information of China (English)

    LuHongwei

    2004-01-01

    Invited by the CPAFFC, Michael Cohrs, Chief Executive Officer of the Corporate and Investment Banking of Deutsche Bank, visited Beijing from February 26 to 28, 2004. Vice Premier Zeng Peiyan of the State Council met with Cohrs and his party.

  4. The big picture : What the Baltics may learn from Ireland's success story / Michael Bourke ; interv. Maris Biezaitis

    Index Scriptorium Estoniae

    Bourke, Michael

    2002-01-01

    Ilmunud ka: Baltiiskii kurss 2002/Zima/Vesna nr. 20 lk. 14-17. Iirimaa aukonsul Lätis, Michael Joseph Bourke arutleb Iirimaa majandusedu teemal ning pakub välja, mida Baltimaad saaksid sellest õppida. Tabel, diagramm. Lisa

  5. The big picture : What the Baltics may learn from Ireland's success story / Michael Bourke ; interv. Maris Biezaitis

    Index Scriptorium Estoniae

    Bourke, Michael

    2002-01-01

    Ilmunud ka: Baltiiskii kurss 2002/Zima/Vesna nr. 20 lk. 14-17. Iirimaa aukonsul Lätis, Michael Joseph Bourke arutleb Iirimaa majandusedu teemal ning pakub välja, mida Baltimaad saaksid sellest õppida. Tabel, diagramm. Lisa

  6. Michael T. Westrate. Living Soviet in Ukraine from Stalin to Maidan: Under the Falling Red Star in Kharkiv.

    Directory of Open Access Journals (Sweden)

    Charitie V. Hyman

    2017-09-01

    Full Text Available Book review of Michael T. Westrate. Living Soviet in Ukraine from Stalin to Maidan: Under the Falling Red Star in Kharkiv. Rowman & Littlefield, 2016. xx, 232 pp. Illustrations. Appendices. Bibliography. Index. $85.00, cloth.

  7. 77 FR 40878 - Californians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey, v. California Public...

    Science.gov (United States)

    2012-07-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Californians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey, v. California Public Utilities Commission, California Department of Water Resources, Pacific Gas...

  8. Asymmetric Synthesis of Substituted Thiolanes through Domino Thia-Michael-Henry Dynamic Covalent Systemic Resolution using Lipase Catalysis.

    Science.gov (United States)

    Zhang, Yan; Vongvilai, Pornrapee; Sakulsombat, Morakot; Fischer, Andreas; Ramström, Olof

    2014-03-24

    Dynamic systems based on consecutive thia-Michael and Henry reactions were generated and transformed using lipase-catalyzed asymmetric transformation. Substituted thiolane structures with three contiguous stereocenters were resolved in the process in high yields and high enantiomeric excesses.

  9. Pursuing perfection: an interview with Don Berwick and Michael Rothman. Interview by Andrea Kabcenell and Jane Roessner.

    Science.gov (United States)

    Berwick, Don; Rothman, Michael

    2002-05-01

    Don Berwick and Michael Rothman discuss the Pursuing Perfection initiative, which is intended to help health care organizations integrate improvement work into day-to-day life, with systemwide changes in infrastructure, project management, care, and leadership.

  10. Tagasipöördumine esteetika juurde = Return to aesthetics / Keith Moxey, Michael Ann Holly ; interv. Anu Allas

    Index Scriptorium Estoniae

    Moxey, Keith

    2007-01-01

    Ameerika kunstiajaloolased Keith Moxey ning Michael Ann Holly tutvustavad uut lähenemist kunstiajaloole (new art history). Nn. naasmine esteetika juurde tähendab püüet integreerida kunstiajalukku ja -teooriasse uuesti ja tugevamalt kunstiteos

  11. A perspectiva de Michael Apple para os estudos das políticas educacionais

    Directory of Open Access Journals (Sweden)

    Luís Armando Gandin

    Full Text Available Resumo Este artigo tem como objetivo analisar as contribuições de Michael Apple para o campo da pesquisa em políticas educacionais. Na extensa obra de Michael Apple, destacamos seis elementos que podem auxiliar aqueles que estão interessados na área de políticas em educação: o princípio epistemológico da análise relacional; o exame do Estado como relação; a herança de Antonio Gramsci e de Raymond Williams que Michael Apple incorpora no uso de conceitos como hegemonia e senso comum; a análise que Michael Apple faz das políticas educacionais como políticas culturais, como disputas por visão de mundo, como luta por consolidação de uma hegemonia que vai além do econômico; a sua postura de pesquisador; e a capacidade que Michael Apple tem de ir além da lógica da reprodução e determinação para enfatizar o papel da agência e da contra-hegemonia. Através de exemplos práticos da própria obra de Apple e de outras pesquisas empíricas, apresentam-se as implicações de cada um dos seis pontos acima citados para os pesquisadores interessados na área de políticas educacionais. Conclui-se que muitas das contribuições de Apple podem auxiliar em pesquisas nessa área, tendo em vista a discussão que o autor realiza em sua obra e sua crítica ao determinismo econômico nas análises do campo educacional, salientando a importância, assim, de aspectos que estão relacionados à esfera da cultura.

  12. Review: Michael Crandall & Karen E. Fisher (Eds) Digital Inclusion: Measuring the Impact of Information and Community Technology

    DEFF Research Database (Denmark)

    Pors, Niels Ole

    2010-01-01

    Review: Michael Crandall & Karen E. Fisher (Eds) Digital Inclusion: Measuring the Impact of Information and Community Technology. Medford. Information Today. ASIS&T Monographs, 2009. 185 pages. $ 59.50. ISBN 978-1-57387-373-4......Review: Michael Crandall & Karen E. Fisher (Eds) Digital Inclusion: Measuring the Impact of Information and Community Technology. Medford. Information Today. ASIS&T Monographs, 2009. 185 pages. $ 59.50. ISBN 978-1-57387-373-4...

  13. Rh(III)-Catalyzed C-H Bond Addition/Amine-Mediated Cyclization of Bis-Michael Acceptors.

    Science.gov (United States)

    Potter, Tyler J; Ellman, Jonathan A

    2016-08-01

    A Rh(III)-catalyzed C-H bond addition/primary amine-promoted cyclization of bis-Michael acceptors is reported. The C-H bond addition step occurs with high chemoselectivity, and the subsequent intramolecular Michael addition, mediated by a primary amine catalyst, sets three contiguous stereocenters with high diastereoselectivity. A broad range of directing groups and both aromatic and alkenyl C-H bonds were shown to be effective in this transformation, affording functionalized piperidines, tetrahydropyrans, and cyclohexanes.

  14. Review: Michael Crandall & Karen E. Fisher (Eds) Digital Inclusion: Measuring the Impact of Information and Community Technology

    DEFF Research Database (Denmark)

    Pors, Niels Ole

    2010-01-01

    Review: Michael Crandall & Karen E. Fisher (Eds) Digital Inclusion: Measuring the Impact of Information and Community Technology. Medford. Information Today. ASIS&T Monographs, 2009. 185 pages. $ 59.50. ISBN 978-1-57387-373-4......Review: Michael Crandall & Karen E. Fisher (Eds) Digital Inclusion: Measuring the Impact of Information and Community Technology. Medford. Information Today. ASIS&T Monographs, 2009. 185 pages. $ 59.50. ISBN 978-1-57387-373-4...

  15. On the relative preference of enamine/iminium pathways in an organocatalytic Michael addition reaction.

    Science.gov (United States)

    Patil, Mahendra P; Sunoj, Raghavan B

    2009-05-04

    The mechanism of the organocatalyzed Michael addition between propanal and methyl vinyl ketone is investigated using the density functional and ab intio methods. Different modes of substrate activation offered by a secondary amine (pyrrolidine) organocatalyst are reported. The electrophilic activation of enone (P-I) through the formation of an iminium ion, and nucleophilic activation of propanal (P-II) in the form of enamine have been examined by identifying the corresponding transition states. The kinetic preference for the formation of key intermediates is established in an effort to identify the competing pathways associated with the title reaction. A comparison of barriers associated with different pathways as well as intermediate formation allows us to provide a suitable mechanistic rationale for Michael addition reactions catalyzed by a secondary amine. The overall barriers for the C-C bond formation pathways involving enol or iminium intermediates are identified as higher than the enamine pathway. Additionally, the generation of iminium is found to be less favored as compared to enamine formation. The effect of co-catalyst/protic solvent on the energetics of the overall reaction is also studied using the cluster continuum approach. Significant reduction in the activation energies for each step of the reaction is predicted for the solvent-assisted models. The co-catalyst assisted addition of propanal-enamine to methyl vinyl ketone is identified as the most preferred pathway (P-IV) for the Michael addition reaction. The results are in concurrence with the available experimental reports on the rate acceleration by the use of a co-catalyst in this reaction.

  16. Compassionate leadership? Some reflections on the work and life of Michael Lapsley

    Directory of Open Access Journals (Sweden)

    Ian A. Nell

    2016-03-01

    Full Text Available In June 2007, I had the privilege of attending a Healing of Memories workshop lead by Father Michael Lapsley, one of the founder members of the Institute for Healing of Memories. The purpose of the workshop was to help the predominantly white members of a middle class Dutch Reformed congregation in the Northern Suburbs of Cape Town and the predominantly coloured members of a congregation of the Evangelical Lutheran Church in Elsies River on the Cape Flats, to share their stories of the past with regard to apartheid with each other. Apart from the stories that were told and the sharing of experiences about the apartheid history that took place, I was struck by the way in which Father Lapsley conducted the workshop. There was a deep compassion for all the participants as was embodied through the way in which he treated each of us with respect. But apart from his cordiality in leading the workshop, one could sense a deeper source of compassion, a source revealing a compassionate understanding of God�s presence amidst the violence and turmoil in our broken world. The aim of this article is to reflect on whether one could speak of something like �compassionate leadership�, and to take a closer look at the relationship between compassion and God images in the life and work of Michael Lapsley. Special attention will be given to the way in which he exercises leadership through his many involvements related to his own personal story of trauma.Intradisciplinary and/or interdisciplinary implications: This article presents literary research on the notion of compassionate leadership as a specific kind of leadership. The results indicate that the leadership of Father Michael Lapsley does indeed portray features of this kind of leadership. The research can become the source for finding new strategies for religious leadership.

  17. Reply to the comment on "Geochemistry of buried river sediments from Ghaggar Plains, NW India: Multi-proxy records of variations in provenance, paleoclimate, and paleovegetation patterns in the Late Quaternary" by Singh et al. (2016), Palaeogeography, Palaeoclimatology, Palaeoecology 449 (2016) 85-100

    DEFF Research Database (Denmark)

    Singh, Ajit; Paul, Debajyoti; Sinha, Rajiv;

    2016-01-01

    In the comment on our paper (this issue), Clift et al. (2016) compared our recently reported radiogenic Nd-isotopic record in two drill cores (Singh et al., 2016) with those from the Hakra floodplain sediments and Indus Delta sediments. While they agree with the concept of erosion patterns...... in the western Himalayan sources being climatically modulated, they offer an alternative interpretation for our reported variability in the radiogenic Nd-isotopic values. Here, we show that the Nd-isotopic values for the Holocene succession instead can be explained by the bedrock geology of the source region...

  18. Enantio- and Diastereoselective Synthesis of exo-Peroxyacetals: An Organocatalyzed Peroxyhemiacetalization/oxa-Michael Addition Cascade.

    Science.gov (United States)

    Maity, Sanjay; Parhi, Biswajit; Ghorai, Prasanta

    2016-06-27

    An unprecedented enantioselective peroxyhemiacetalization/oxa-Michael addition cascade of ortho-formyl homochalcones has been developed using cinchona-alkaloid-based chiral bifunctional organocatalysts to provide cis-configured exo-peroxyacetals, a new class of organic peroxide, in good yields with excellent enantio- and diastereoselectivities. The resulting cis-configured exo-peroxyacetals were converted into the corresponding trans-configured peroxyacetals without affecting the enantioselectivity. Furthermore, the displacement of the peroxide moiety of exo-peroxyacetals with various nucleophiles has been demonstrated to afford 1,3-disubstituted isochromans with high diastereoselectivities and excellent enantioselectivities. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Michael Porter 30 anos depois de Estratégia Competitiva

    OpenAIRE

    Schneider,Aline; Carneiro,Marcelo; Serra, Fernando; Ferreira, Manuel Portugal

    2008-01-01

    Os estudos de estratégia empresarial têm sido muito influenciados pelos trabalhos de Michael Porter, em particular na estratégia competitiva, análise da indústria e das vantagens competitivas das nações. Neste artigo, analisamos a influência de Porter nos trabalhos brasileiros em estratégia, a partir dos trabalhos selecionados e apresentados no ENANPAD. No levantamento para a análise dos artigos, considerando 10 anos de ENANPAD (1997 – 2006), foram selecionados 46 artigos. A identificação e s...

  20. Michael Lloyd. Sophocles: Electra : Duckworth, London, 2005, 160 pp.

    OpenAIRE

    Moretti, María Inés

    2008-01-01

    Este estudio sobre Electra de Sófocles pertenece a la serie «Duckworth Companions to Greek and Roman Tragedy», editada por Thomas Harrison, cuyo objetivo es proporcionar introducciones para tragedias antiguas y discutir los aspectos principales de las obras incorporando los nuevos desarrollos de la crítica moderna. Sophocles: Electra de Michael Lloyd, resulta al mismo tiempo un libro simple pero muy completo, didáctico, para un público no especializado, aunque interesante también para los esp...

  1. Critical notice: Michael Tomasello on the “prosocial” human animal

    DEFF Research Database (Denmark)

    Larsen, Steen Nepper

    2014-01-01

    Abstract According to Michael Tomasello humans cannot help to be informative. Apes, like chimps, do not point at each other, only humans do so in order to attract attention, i.e. to (get) help, play and share experiences. In shared cooperative activities, individual rationality is transformed...... of the prosocial nature of the infant lacks convincing arguments; Tomasello reflects and honours the Zeitgeist (i.e. the hope that we will see a scientific shift away from predominant methodological individualism towards more ‘social’ and ‘emphatic’ ways of thinking); his concepts of language as a tool...

  2. The Great War and All That in A Hundred Doors by Michael Longley

    Directory of Open Access Journals (Sweden)

    Elisabeth Delattre

    2015-03-01

    Full Text Available The Great War has featured regularly in Michael Longley’s poetry, for personal, family, aesthetic and political reasons. His collection published in 2011 under the title A Hundred Doors contains a number of poems relating to his father and the so-called War Poets, in connection with others in which love and nature, life and death are also dominant themes. This article will show how, as elsewhere in his poetry, everything is interrelated, “the nature poetry”, in Longley’s words, “fertilizing the war poetry”.

  3. Michael Farquhar, Circuits of Faith: Migration, Education and the Wahhabi Mission

    OpenAIRE

    Pétriat, Philippe

    2017-01-01

    Using the concept of what he calls a “transnational religious economy” centered on the Islamic University of Medina (IUM), Michael Farquhar’s Circuits of Faith is an important and historicized contribution to the debate over the export of Wahhabism and its role in global Salafism. The detailed history of the IUM is probably the main interest of this book based on an array of IUM publications (syllabuses) and interviews. It deals with historicized facts and provides precise knowledge of one o...

  4. An Interview with Michael Betancourt, author of Agnotology & Crisis in Digital Capitalism

    Directory of Open Access Journals (Sweden)

    Sean Scanlan

    2015-03-01

    Full Text Available Sean Scanlan, NANO's editor, interviews artist, curator, art historian and critical theorist Michael Betancourt to discuss the nature of agnotology, a term that means the “creation of uncertainty and ambivalent ‘fact’; it is a competitive tool incompatible with the idealized ‘free market’ of capitalism.” Betancourt is skeptical of Big Data and the ways that the consumers who unknowingly “produce” data for business interpretation are increasingly becoming transformed into a “token of exchange (valorized by the database.”

  5. Michael E. Lamb: Award for Distinguished Senior Career Contributions to Psychology in the Public Interest.

    Science.gov (United States)

    2015-11-01

    The APA Awards for Distinguished Contributions to Psychology in the Public Interest recognize persons who have advanced psychology as a science and/or profession by a single extraordinary achievement or a lifetime of outstanding contributions in the public interest. The 2015 co-recipient of the Award for Distinguished Senior Career Contributions to Psychology in the Public Interest is Michael E. Lamb. Lamb was selected because his "work profoundly shaped the fields of developmental psychology, social welfare, child and family policy, and law." Lamb's award citation, biography, and a selected bibliography are presented here.

  6. Asymmetric synthesis of fully substituted cyclopentane-oxindoles through an organocatalytic triple Michael domino reaction.

    Science.gov (United States)

    Zou, Liang-Hua; Philipps, Arne R; Raabe, Gerhard; Enders, Dieter

    2015-01-12

    An efficient, highly stereoselective asymmetric synthesis of fully functionalized cyclopentanes bearing an oxindole moiety and several other functional groups in one pot has been developed. Key step is an organocatalytic triple Michael domino reaction forming three C-C bonds and six stereocenters, including a quaternary one. Starting from equimolar amounts of simple substrates, a high molecular complexity can be reached after a Wittig olefination in one pot. The new protocol can easily be scaled up to gram amounts. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Social and Racial Problem Exposed in Michael Jackson’s Selected Songs

    OpenAIRE

    2015-01-01

    In this thesis, I analyze some of Michael Jackson’ songs which concern to the negatively social and racial problem. Social problem that happened to the society in this world, then racial problem that happened to the Black people, such as: Skin Color, Prejudice, Discrimination, Stereotypes, and Racial Segregation. In his songs entitled Heal The World, We Are The World, and The Man In The Mirror have the meaning of to make a better world. Other songs entitled Black or White, and They Don’t Care...

  8. Michael Butter, Patrick Keller, and Simon Wendt, eds. Arnold Schwarzenegger: Interdisciplinary Perspectives on Body and Image.

    OpenAIRE

    Liokaftos, Dimitrios

    2012-01-01

    Arnold Schwarzenegger: Interdisciplinary Perspectives on Body and Image has been edited by Michael Butter, Patrick Keller, and Simon Wendt, all of whom have contributed individual essays to the volume.Most of the essays appearing in this collection were first presented at the “Arnold Schwarzenegger: Interdisziplinäre Perspektiven auf Körper und Image” conference that took place at the Heidelberg Centre for American Studies from September 18-20, 2009. Although there is no formal division of th...

  9. 专访BEA首席技术专家Michael Smith

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    WebLogic Platform8.1是BEA第一款中文化的产品.由此也足见BEA对这款产品以及中国市场的重视。为了这次“开发者日”.BEA公司CTO办公室首席技术专家Michael Smith也赶到中国.并接受了笔者的专访。以下是关于WebLogic Platform的对话。

  10. Realismo y antirrealismo en la filosofía de Michael Dummett

    OpenAIRE

    Pablo Cubides; David González; David Rey

    2013-01-01

    Michael Dummett es reconocido por haber propuesto una caracterización semántica del debate realismo-antirrealismo. A partir de esta caracterización, Dummett busca defender una aproximación ascendente a los problemas metafísicos tradicionales, la cual consiste en resolver los desacuerdos metafísicos entre el realista y el antirrealista mediante la elaboración de teorías semánticas para ciertos conjuntos de enunciados. En este artículo argumentamos que la caracterización de Dummett no captura l...

  11. Elevated levels of 4-hydroxynonenal-histidine Michael adduct in the hippocampi of patients with Alzheimer's disease.

    Science.gov (United States)

    Fukuda, Mitsugu; Kanou, Fumihisa; Shimada, Nobuko; Sawabe, Motoji; Saito, Yuko; Murayama, Shigeo; Hashimoto, Masakatsu; Maruyama, Naoki; Ishigami, Akihito

    2009-08-01

    Alzheimer's disease (AD) is among the most common causes of progressive cognitive impairment in humans and is characterized by neurodegeneration in the brain. Lipid peroxidation is thought to play a role in the pathogenesis of AD. 4-hydroxynonenal (HNE) results from peroxidation of polyunsaturated fatty acids and it in turn gives evidence of lipid peroxidation in vivo. HNE reacts with protein histidine residue to form a stable HNE-histidine Michael adduct. To clarify the influence of lipid peroxidation on the pathogenesis of AD, we measured HNE-histidine Michael adduct in hippocampi from four AD patients and four age-matched controls by means of semiquantitative immunohistochemistry using a specific antibody to cyclic hemiacetal type of HNE-histidine Michael adduct. This antibody does not react with the ring-opened form of HNE-histidine Michael adduct and the pyrrole form of HNE-lysine Michael adduct. The HNE adduct was detected in the hippocampi of both AD and control donors, especially in the CA2, CA3 and CA4 sectors. Immunoreactive intensity of HNE adduct in these sectors were significantly higher in AD patients than in the controls. The HNE adduct was found in the perikarya of pyramidal cells in the hippocampus. These results show that the hippocampi of patients with AD undergo lipid peroxidation and imply that this activity underlies the production of cytotoxic products such as HNE that are responsible for the pathogenesis of AD.

  12. LECTURE CANCELLED - “The power of collaboration - innovating collaborative relationships" by Michael Kimmel | 8 March

    CERN Multimedia

    2013-01-01

    PLEASE NOTE THAT THIS LECTURE IS CANCELLED Friday, 8 March -  from 11.30 a.m. to 1 p.m. Globe of Science and Innovation Route de Meyrin, 1211 Geneva International Women’s Day Conference Lecture will be in English - Interpreting available in French Limited number of seats - registration is essential Reservation: + 41 22 767 76 76 or cern.reception@cern.ch Dr. Michael Kimmel, a renowned sociologist and an expert on male-female relationships, will share his latest findings on gender collaboration and how it can lead to innovation and improved relationships both at work and in the world outside. Michael Kimmel is among the world’s leading experts on male-female relationships. A Professor of Sociology at the State University of New York at Stony Brook, he is the author or editor of more than 20 books on the topic. He consults corporations, NGOs and public sector organisations all over the world on gender equity issues, including work-family balance, reducing workplac...

  13. The role of noninnocent solvent molecules in organocatalyzed asymmetric Michael addition reactions.

    Science.gov (United States)

    Patil, Mahendra P; Sunoj, Raghavan B

    2008-01-01

    A proline-catalyzed asymmetric Michael addition between ketones and trans-beta-nitrostyrene was studied by using the density-functional theory with mPW1PW91 and B3LYP functionals. Improved insight into the enantio- and diastereoselective formation of gamma-nitroketones/-aldehydes is obtained through transition-state analysis. Consideration of the activation parameters obtained from gas-phase calculations and continuum solvation models failed to reproduce the reported experimental stereoselectivities for the reaction between cyclohexanone and 3-pentanone with trans-beta-nitrostyrene. The correct diastereo- and enantioselectivites were obtained only upon explicit inclusion of solvent molecules in the diastereomeric transition states that pertain to the C--C bond formation. Among the several transition-state models that were examined, the one that exhibits cooperative hydrogen-bonding interactions with two molecules of methanol could explain the correct stereochemical outcome of the Michael reaction. The change in differential stabilization that arises as a result of electrostatic and hydrogen-bonding interactions in the key transition states is identified as the contributing factor toward obtaining the correct diastereomer. This study establishes the importance of including explicit solvent molecules in situations in which the gas-phase and continuum models are inadequate in obtaining meaningful insight regarding experimental stereoselectivities.

  14. Adapting Shakespeare – Converting Shylock in Michael Radford’s the Merchant of Venice

    Directory of Open Access Journals (Sweden)

    Oakes Luke

    2016-08-01

    Full Text Available This article aims to explore the extension and evolution of Shakespeare’s The Merchant of Venice through Michael Radford’s 2004 cinematic adaptation. By investigating the concept of adaptation and the significance of intertextuality, Shakespeare’s source text is considered alongside Radford’s twenty-first century recreation to reimagine and redefine the construction of Shylock as both a comic and tragic device utilized across film and play. Issues of racial and religious prejudices alongside anti- Semitic views were particularly prominent in Elizabethan England and, by concentrating on recontextualisation, this article looks to expose Shakespeare’s characterization as a reflective commentary concerning societal discriminations at the time of the play’s performance. By focusing primarily on Shakespeare’s Jewish Usurer, Radford is able to reconstruct and reestablish the dramatic devices and characters within the cinematic version, metaphorically converting Shylock from comic villain to tragic victim. Finally, it argues that this dynamic shift inevitably metamorphoses Shylock from a spectator’s perspective and provides Michael Radford with an opportunity to offer a social commentary on social inequality in the twenty-first century.

  15. Bioengineered vascular graft with autologous stem cells: first use in the clinic. Interview with Michael Olausson.

    Science.gov (United States)

    Olausson, Michael

    2012-11-01

    Michael Olausson talks to Regenerative Medicine about the pioneering clinical use of a bioengineered vascular graft to treat a 9-year-old girl with extrahepatic portal vein obstruction and the future potential of bioengineered vessels. Michael Olausson has been Professor of Transplantation Surgery at Gothenburg University (Gothenburg, Sweden) since 2000, and was Chairman of the Sahlgrenska Transplant Institute at Sahlgrenska University Hospital (Gothenburg, Sweden) between 1994 and June 2011. His scientific interests include transplant immunology and experimental and clinical transplantation studies. He has published over 240 original articles, reviews and book chapters in the field of transplantation. He has been invited as a speaker at several national and international meetings all over the world. He has pioneered several innovative surgical procedures in the Nordic countries, Europe and the rest of the world. Last year, he performed the first operation in the world using a stem cell-derived vein and recently he performed the two first mother-to-daughter live donor uterus transplantations in the world, together with a team from Gothenburg. In the past, he has been President of The Swedish Transplantation Society, and board member and Vice President of the European Liver and Intestinal Transplantation Association. In 2008 he received the Carl-Gustav Groth Scandinavian Transplant Prize.

  16. Traces of the Unrepresentable in the Modernist Discourse of Clement Greenberg and Michael Fried

    Directory of Open Access Journals (Sweden)

    Gal, Nissim

    2013-08-01

    Full Text Available The present essay aims to remap the modernist writing of Clement Greenberg and his successor Michael Fried from the late 1930s to the 1960s. For many years these two critics/theorists were considered leaders of the American modernist camp that promoted the purity of the medium and the total dependence of reading art on the primacy of perception. Attentive reading of the canonical texts they authored will surprisingly reveal that between the theoretical lines of their writings dwells an essential element that contradicts the absolute dominance of eyesight. Lying at the heart of the Greenbergian act is a metaphysical foundation that poses the question of the invisible as part of the inquiry into the "essence of the visible". As such the modernist debate will be revealed not only as a means for assembling a canon of works, but also as a means to formulating an experience of revelation in terms of the visual. Attentive reading of the writings of Clement Greenberg and the early Michael Fried, reveals a theoretical element or regulative idea that will be termed here "the unrepresentable".

  17. A polystyrene-supported 9-amino(9-deoxy)epi quinine derivative for continuous flow asymmetric Michael reactions.

    Science.gov (United States)

    Izquierdo, Javier; Ayats, Carles; Henseler, Andrea H; Pericàs, Miquel A

    2015-04-14

    A polystyrene (PS)-supported 9-amino(9-deoxy)epi quinine derivative catalyzes Michael reactions affording excellent levels of conversion and enantioselectivity using different nucleophiles and structurally diverse enones. The highly recyclable, immobilized catalyst has been used to implement a single-pass, continuous flow process (residence time: 40 min) that can be operated for 21 hours without significant decrease in conversion and with improved enantioselectivity with respect to batch operation. The flow process has also been used for the sequential preparation of a small library of enantioenriched Michael adducts.

  18.  Bibliographie annotée des œuvres publiées de Michael Leff

    Directory of Open Access Journals (Sweden)

    Steven R. Edscorn

    2011-04-01

    Full Text Available LivresLeff, Michael & Fred Kauffeld (eds. 1989. Texts in Contexts: Dialogues on Significant Episodes in American Political Rhetoric [Textes en contexte : dialogues sur les épisodes significatifs de la rhétorique politique américaine] (Davis: Hermagoras PressCe recueil de dialogues tente de recréer l’esprit et l’orientation des discussions tenues au cours du « Symposium du Wisconsin sur le discours public : études de cas de rhétorique politique ». Horner, Winifred & Michael Leff (eds. 1995....

  19. Isoindolinones as Michael Donors under Phase Transfer Catalysis: Enantioselective Synthesis of Phthalimidines Containing a Tetrasubstituted Carbon Stereocenter

    Directory of Open Access Journals (Sweden)

    Francesco Scorzelli

    2015-05-01

    Full Text Available Readily available chiral ammonium salts derived from cinchona alkaloids have proven to be effective phase transfer catalysts in the asymmetric Michael reaction of 3-substituted isoindolinones. This protocol provides a convenient method for the construction of valuable asymmetric 3,3-disubstituted isoindolinones in high yields and  moderate to good enantioselectivity. Diastereoselectivity was also investigated in the construction of contiguous tertiary and quaternary stereocenters. The use of acrolein as Michael acceptor led to an interesting tricyclic derivative, a pyrroloisoindolinone analogue, via a tandem conjugated addition/cyclization reaction.

  20. N-Heterocyclic Carbene-Catalysed Diastereoselective Vinylogous Michael Addition Reaction of gamma-Substituted deconjugated Butenolides

    KAUST Repository

    Guo, Hao

    2015-11-16

    An efficient N-heterocyclic carbene (NHC)-catalysed vinylogous Michael addition of deconjugated butenolides was developed. In the presence of 5 mol% of the NHC catalyst, both γ-alkyl and aryl-substituted deconjugated butenolides undergo vinylogous Michael addition with various α, β-unsaturated ketones, esters, or nitriles to afford γ,γ-disubstituted butenolides containing adjacent quaternary and tertiary carbon centers in good to excellent yields with excellent diastereoselectivities. In this process, the free carbene is assumed to act as a strong Brønsted base to promote the conjugate addition.

  1. Michael Hauskeller: Sex and the Posthuman Condition : Palgrave-Macmillan, 2014, 98 pp.

    Science.gov (United States)

    Miller, Lantz Fleming

    2016-10-01

    This new book from Michael Hauskeller explores the currently marketed or projected sex/love products that exhibit some trait of so-called "posthumanistic" theory or design. These products are so designated because of their intention to fuse high technologies, including robotics and computing, with the human user. The author offers several arguments for why the theory behind these products leads to inconsistencies. The book uses a unique approach to philosophical argument by enmeshing the argument's major points in a concomitant discussion of pieces from world literature pertaining to posthumanism. The method is compelling, heightened by great world authorial insights that rarely find their way into philosophy and shores up some strong argumentative points. Yet some of the argument still needs more elucidating.

  2. Tradições e rupturas no cinema político de Michael Moore

    OpenAIRE

    Cristiane Toledo Maria

    2015-01-01

    Esta pesquisa tem como objetivo analisar a produção fílmica do cineasta norte-americano Michael Moore, tendo como questão central a relação que se estabelece entre arte e política num momento histórico que, de um lado, aponta para a crise do capitalismo e, de outro, para a fragmentação política da classe trabalhadora. A partir da análise formal de dois de seus filmes, estabelecemos uma relação com os momentos históricos que lhes deram condições de produção, a fim de compreender o método desen...

  3. A highly selective fluorescent probe based on Michael addition for fast detection of hydrogen sulfide

    Science.gov (United States)

    Gao, Baozhen; Cui, Lixia; Pan, Yong; Xue, Minjie; Zhu, Boyu; Zhang, Guomei; Zhang, Caihong; Shuang, Shaomin; Dong, Chuan

    2017-02-01

    A new 4-hydroxy-1,8-naphthalimide-based compound (probe 1) has been designed and synthesized. The colorimetric and fluorescent properties of probe 1 towards hydrogen sulfide (H2S) were investigated in detail. The results show that the probe 1 could selectively and sensitively recognize H2S rather than other reactive sulfur species. The reaction mechanism of this probe is an intramolecular cyclization caused by the Michael addition of H2S to give 4-hydroxy-1,8-naphthalimide. The intramolecular charge transfer of 4-hydroxy-1,8-naphthalimide is significant. Probe 1 quickly responded to H2S and showed a 75-fold fluorescence enhancement in 5 min. Moreover, probe 1 could detect H2S quantitatively with a detection limit as low as 0.23 μM.

  4. Michael Kwass, Contraband: Louis Mandrin and the Making of a Global Underground.

    OpenAIRE

    Goldner, Erik

    2015-01-01

    C’est une plongée dans les « profondeurs de l’économie souterraine » destinée à éclairer « le côté obscur de la mondialisation » que propose Michael Kwass (p. 9). Dès l’introduction, l’auteur reproche à Daniel Roche et aux historiens français qui l’ont suivi de donner une vision trop optimiste de la « révolution de la consommation » du XVIIIe siècle considérée comme un moteur d’émancipation individuelle et de démocratisation sociale d’objets, de pratiques et d’idées. Selon lui, cette vision p...

  5. Inverting the diastereoselectivity of the mukaiyama-michael addition with graphite-based catalysts

    KAUST Repository

    Acocella, Maria Rosaria

    2014-02-07

    Here, we show that graphite-based catalysts, mainly graphite oxide (GO) and exfoliated GO, are effective recyclable catalysts for a relevant stereoselective Mukaiyama-Michael addition, outperforming currently available catalysts. Moreover, the graphite-based catalysts described here invert the diastereoselectivity relative to that observed with known catalysts, with the unprecedented large prevalence of the anti diastereoisomer. This inverted diastereoselectivity is increased when the catalyst concentration is reduced and after catalyst recycling. Density functional theory calculations suggest that the selectivity is determined by two types of supramolecular interactions operating between the catalyst and the substrates at the diastereoselectivity- determining transition state, specifically, the π-stacking of b-nitrostyrene with graphite and the van der Waals interaction between the SiMe3 group of the silyl ether and the graphite. © 2013 American Chemical Society.

  6. A metal-ligand cooperative pathway for intermolecular oxa-Michael additions to unsaturated nitriles.

    Science.gov (United States)

    Perdriau, Sébastien; Zijlstra, Douwe S; Heeres, Hero J; de Vries, Johannes G; Otten, Edwin

    2015-03-27

    An unprecedented catalytic pathway for oxa-Michael addition reactions of alcohols to unsaturated nitriles has been revealed using a PNN pincer ruthenium catalyst with a dearomatized pyridine backbone. The isolation of a catalytically competent Ru-dieneamido complex from the reaction between the Ru catalyst and pentenenitrile in combination with DFT calculations supports a mechanism in which activation of the nitrile through metal-ligand cooperativity is a key step. The nitrile-derived Ru-N moiety is sufficiently Brønsted basic to activate the alcohol and initiate conjugate addition of the alkoxide to the α,β-unsaturated fragment. This reaction proceeds in a concerted manner and involves a six-membered transition state. These features allow the reaction to proceed at ambient temperature in the absence of external base. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Biotechnology Unglued: Science, Society & Social Cohesion, by Michael D. Mehta (Ed.

    Directory of Open Access Journals (Sweden)

    Kimiko Inouye

    2007-05-01

    Full Text Available Biotechnology Unglued: Science, Society & Social Cohesion engages with issues such as farming, food safety, genetic database collections, DNA testing, bioprospecting, and intellectual property. The intention of editor Michael Mehta is to examine these issues in relation to how they impact the social cohesion of society, in particular of communities more directly impacted. For example, Mehta writes about how genetically engineered seed technologies have impacted farming communities in Canada, while Jacqueline Broerse and Joske Bunders examine how these same technologies affect smaller-scale, resource-poor farmers in the South, and Kyle Eischen discusses the implications for the Icelandic population as a result of the creation of a national Iceland Genetic Database, which is largely controlled by the DeCode Genetics company.

  8. Rationalism and traditionalism in politics. The correspondence between Karl R. Popper and Michael Oakeshott

    Directory of Open Access Journals (Sweden)

    Spartaco Pupo

    2016-07-01

    Full Text Available The correspondence of 1948 between Karl Popper and Michael Oakeshott, translated for the first time in Italian and published in the appendix to this paper, demonstrates the existence of two different ways of thinking about politics: the rationalist approach, founded on the “argumentation” as a rational means for the non-violent solution of problems (Popper, and the traditionalist mode, inspired by the method of “conversation” as a guarantee of constant openness to the diversity of identities (Oakeshott. To rise from the letters is a mutual influence on the interpretation of the key concepts that characterize the thought of the two authors, which however does not cancel the fundamental divergence of their political orientation.

  9. A History of Experiences and Thinking Men. The History of Political Thought according to Michael Oakeshott

    Directory of Open Access Journals (Sweden)

    Spartaco Pupo

    2014-12-01

    Full Text Available Michael Oakeshott conceives the history of European political thought as a structuring of ideas and arguments of the practical experience aimed to understanding political expressions in vogue in the culture of a people. It is not a continuous and cumulative history of abstract and disembodied ideas, as it is wrongly conceived, but of some men who thought politics in a certain way on the basis of the language and of the set of actions, moral beliefs and contingencies of the people which they belong to. The article highlights the comparison between Oakeshott, Quentin Skinner and Gianfranco Miglio on the search for the most appropriate method to be applied in the study of the history of political thought.

  10. Apparent truth and false reality: Michael Crichton and the distancing of scientific discourse

    OpenAIRE

    Genty, Stéphanie

    2012-01-01

    La représentation d'un milieu professionnel dans la FASP est censée être authentique dans la mesure où l'auteur est de façon générale issu du milieu décrit et/ou jouit de liens privilégiés avec ce dernier. Deux romans de l'auteur américain Michael Crichton, La variété d'Andromède (1969) et État d'urgence (2004), qui se prêtent à une lecture en tant que FASP, minent quelque peu cette supposition. Le fait que l’auteur a recours à de faux documents et à de vrais articles de recherche brouille le...

  11. Michael Fordham and the Journal of Analytical Psychology: the view from Hangman's Hill.

    Science.gov (United States)

    Urban, Elizabeth

    2015-09-01

    This short paper was presented to a conference in honour of the 60(th) year of the JAP and was one of others that acknowledged the contribution of Michael Fordham. The subtitle refers to the paper's overview of Fordham's published oeuvre and the particular place of the Journal of Analytical Psychology, for which he was the founding editor. Fordham's contribution to a Jungian-based model of development is discussed, with reference to his papers in the British Journal of Medical Psychology. The paper notes miscellaneous pieces from Fordham's commentaries, obituaries, papers and reviews which capture not only the development of Fordham as a thinker but also his character. There is discussion of his reviews of Melanie Klein's Envy and Gratitude and manuscripts by Erich Neumann. A reminiscence of Fordham as supervisor is recounted.

  12. Linguistic Theories and Intellectual History in Michael Baxandall’s Giotto and the Orators

    Directory of Open Access Journals (Sweden)

    Allan Langdale

    2009-12-01

    Full Text Available This essay examines some theoretical and methodological aspects of Michael Baxandall’s book Giotto and the Orators. Humanist observers of painting in Italy and the discovery of pictorial composition of 1971. It includes reflections on the book’s reorientations of the scholarly debate over the relationship between Renaissance/Early Modern humanism and painting, as well as consideration of the linguistic theories that either directly or tangentially inform Baxandall’s method. Sources such as Wittgenstein, Cassirer, Ordinary Language Philosophy, and the Sapir-Whorf Hypothesis are discussed. Some of the book’s aims and methods are clarified by a comparison to Panofsky’s Gothic Architecture and Scholasticism of 1951.

  13. 'Introducing Michael Gove to Loïc Wacquant': Why Social Work Needs Critical Sociology.

    Science.gov (United States)

    Michael Garrett, Paul

    2016-06-01

    In 2013, Michael Gove, then Secretary of State for Education and Health in the UK coalition government, criticised social workers for laying insufficient emphasis on the 'agency' of individuals and for being too preoccupied with social and economic inequalities. Such a perspective, which is not unique to Gove, needs to be countered by reaffirming the significance of an expansively critical sociology for social work. In this context, the thematic concerns of the French theorist, Loïc Wacquant, illuminates key aspects of social work engagement with clients which Gove and his ideological associates appear intent on ignoring. The issues raised have significant political resonances given the pending UK General Election taking place in May 2015.

  14. Phospha-Michael Addition as a New Click Reaction for Protein Functionalization.

    Science.gov (United States)

    Lee, Yan-Jiun; Kurra, Yadagiri; Liu, Wenshe R

    2016-03-15

    A new type of click reaction between an alkyl phosphine and acrylamide was developed and applied for site-specific protein labeling in vitro and in live cells. Acrylamide is a small electrophilic olefin that readily undergoes phospha-Michael addition with an alkyl phosphine. Our kinetic study indicated a second-order rate constant of 0.07 m(-1)  s(-1) for the reaction between tris(2-carboxyethyl)phosphine and acrylamide at pH 7.4. To demonstrate its application in protein functionalization, we used a dansyl-phosphine conjugate to successfully label proteins that were site-specifically installed with N(ɛ) -acryloyl-l-lysine and employed a biotin-phosphine conjugate to selectively probe human proteins that were metabolically labeled with N-acryloyl-galactosamine. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. "Alarme de incêndio": Michael Löwy e a crítica ecossocialista da civilização capitalista moderna "Fire alarm": Michael Löwy and the ecosocialist critique of the modern capitalist civilization

    Directory of Open Access Journals (Sweden)

    Fabio Mascaro Querido

    2013-04-01

    Full Text Available A emergência da crise ecológica, como sintoma mais nítido de uma verdadeira crise civilizató-ria, impôs novos desafios ao pensamento crítico e, em especial, ao marxismo. Partindo desse pressuposto, o objetivo deste artigo é apresentar a defesa de Michael Löwy de uma radicalização ecossocialista da crítica marxista da modernidade, tarefa para a qual a grande recusa de Walter Benjamin das ideologias do pro- gresso é uma das fontes decisivas de inspiração. Para Michael Löwy, a ruptura com as ideologias do progresso e com o paradigma civilizatório capitalista moderno é uma condição indispensável para a atua-lização ecossocialista do marxismo.The emergence of the ecological crisis as a clearer symptom of a true civilizatory crisis has imposed new challenges to critical thought and, in particular, to Marxism. Based on this assumption, this article aims to present Michael Löwy's defense of an ecosocialist radicalization of the Marxist critique of modernity, a task for which Walter Benjamin's great refusal of the ideologies of progress is one of the critical sources of inspiration. To Michael Löwy, breaking away from the ideologies of progress and from the modern capitalistic civilizatory paradigm is a prerequisite for the ecosocialist updating of Marxism.

  16. Enantioselective Michael reaction catalyzed by well-defined chiral ru amido complexes: isolation and characterization of the catalyst intermediate, ru malonato complex having a metal-carbon bond.

    Science.gov (United States)

    Watanabe, Masahito; Murata, Kunihiko; Ikariya, Takao

    2003-06-25

    Chiral Ru amido complexes promote asymmetric Michael addition of malonates to cyclic enones, leading to Michael adducts with excellent ee's, in which the chiral Ru amido complexes react with malonates to give isolable catalyst intermediates, chiral Ru malonato complexes bearing a metal bound C-nucleophile.

  17. Book Review: America’s Blind Spot: Chávez, Oil and US Security by Andrés Cala and Michael Economides

    DEFF Research Database (Denmark)

    Boscan, Luis

    2014-01-01

    Review of: America’s Blind Spot: Chávez, Oil and US Security. Andrés Cala and Michael Economides. Continuum Books. 2012.......Review of: America’s Blind Spot: Chávez, Oil and US Security. Andrés Cala and Michael Economides. Continuum Books. 2012....

  18. Der Wert von Worten. Michael Serrer aus dem Literaturbüro Düsseldorf im Interview mit der Textpraxis-Redaktion

    Directory of Open Access Journals (Sweden)

    Michael Serrer

    2014-11-01

    Full Text Available Die Textpraxis-Redaktion unterhält sich mit Michael Serrer über Literaturvermittlung in Zeiten der Digitalisierung, über Kanonisierung und die Rolle der Literatur in der Gesellschaft. Michael Serrer ist Leiter des Literaturbüros NRW und Feuilletonist.

  19. Aza‐Michael addition reaction: Post‐polymerization modification and preparation of PEI/PEG‐based polyester hydrogels from enzymatically synthesized reactive polymers

    DEFF Research Database (Denmark)

    Hoffmann, Christian; Stuparu, Mihaiela C.; Daugaard, Anders Egede

    2015-01-01

    monomers provides the polyesters, which carry an activated carbon‐carbon double bond in the polymer backbone. These electron deficient alkenes represent suitable aza‐Michael acceptors and can be engaged in a nucleophilic addition reaction with small molecular mono‐amines (aza‐Michael donors) to yield...

  20. Michael Francis Madelin (1931--2007): a pioneer in the biology and ecology of conidial fungi and slime moulds.

    Science.gov (United States)

    Campbell, Richard

    2008-12-01

    Michael F Madelin (1931--2007) was Programme Secretary, Vice-President, and President of the British Mycological Society. A summary of his research on Coprinopsis, various conidial fungi, Coelomomyces and myxomycetes is presented, with a full list of his publications. His teaching career was initially at Imperial College, University of London, and then mostly at the University of Bristol.

  1. Rezension: Österreichische Archivgeschichte. Vom Spätmittelalter bis zum Ende des Papierzeitalters von Michael Hochedlinger

    Directory of Open Access Journals (Sweden)

    Valerie Strunz

    2014-12-01

    Full Text Available Valerie Strunz hat für die LeserInnen der MEDIENIMPULSE die 'Österreichische Archivgeschichte' von Michael Hochedlinger rezensiert. Der Band ist eine Fundgrube für alle, die sich für Geschichte und das Archiv interessieren ...

  2. N-Heterocyclic-Carbene-Catalysed Diastereoselective Vinylogous Mukaiyama/Michael Reaction of 2-(Trimethylsilyloxy)furan and Enones

    KAUST Repository

    Wang, Ying

    2015-10-15

    N-heterocyclic carbenes have been utilised as highly efficient nucleophilic organocatalysts to mediate vinylogous Mukaiyama/Michael reactions of 2-(trimethylsilyloxy)furan with enones to afford γ-substituted butenolides in 44-99% yield with 3:1-32:1 diastereoselectivity. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Chemistry of sulfonylmethyl isocyanides. 45. A direct synthesis of 2-(trimethylstannyl)pyrroles from Michael acceptors and stannylated tosylmethyl isocyanide

    NARCIS (Netherlands)

    Dijkstra, HP; ten Have, Ronald; van Leusen, A.M.

    1998-01-01

    A series of 2-(trimethylstannyl)pyrroles 3, with substituents at the 3- and 4-positions, is synthesized efficiently by a base-induced reaction of stannylated TosMIC with Michael accepters. Stills cross-couplings with bromobenzene and double cross-couplings with 1,4-dibromobenzene have been achieved

  4. Michael Novak's "Business as a Calling" as a Vehicle for Addressing Ethical and Policy Concerns in a Business Law Course

    Science.gov (United States)

    Murphy, Tonia Hap

    2008-01-01

    This article describes the author's experience of incorporating Michael Novak's "Business as a Calling: Work and the Examined Life" into a Business Law course. The author views it as a positive addition to the course, one that may be of interest to her colleagues at other institutions. Accordingly, after an overview of Novak's analysis in…

  5. 76 FR 44901 - Californians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v. California Public...

    Science.gov (United States)

    2011-07-27

    ... No: 2011-18909] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL11-52-000] Californians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v. California Public Utilities Commission, Pacific Gas and Electric Company Southern California Edison Company, San Diego Gas &...

  6. 78 FR 2393 - CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v. California Public...

    Science.gov (United States)

    2013-01-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v. California Public Utilities Commission, Pacific Gas and Electric Company, Contra Costa Generating Station...

  7. Antimicrobial and antifouling hydrogels formed in situ from polycarbonate and poly(ethylene glycol) via Michael addition.

    Science.gov (United States)

    Liu, Shao Qiong; Yang, Chuan; Huang, Yuan; Ding, Xin; Li, Yan; Fan, Wei Min; Hedrick, James L; Yang, Yi-Yan

    2012-12-18

    A novel class of antimicrobial cationic polycarbonate/PEG hydrogels are designed and synthesized by Michael addition chemistry. These hydrogels demonstrate strong broad-spectrum antimicrobial activities against various clinically isolated multidrug-resistant microbes. Moreover, they exhibit nonfouling properties and prevent the substrate from microbial adhesion. These antimicrobial and antifouling gels are promising materials as catheter coatings and wound dressings to prevent infections.

  8. Enantioselective synthesis of benzofurans and benzoxazines via an olefin cross-metathesis-intramolecular oxo-Michael reaction.

    Science.gov (United States)

    Zhang, Jun-Wei; Cai, Quan; Gu, Qing; Shi, Xiao-Xin; You, Shu-Li

    2013-09-11

    Chiral phosphoric acid and Hoveyda-Grubbs II were found to catalyze an olefin cross-metathesis-intramolecular oxo-Michael cascade reaction of the ortho-allylphenols and enones to provide a variety of benzofuran and benzoxazine derivatives in moderate to good yields and enantioselectivity.

  9. "Stand Therefore!" -Bishop Michael Bolton Furse, the Diocese of St. Albans, and the Church Schools Controversy, 1919-1939.

    Science.gov (United States)

    Parker, David

    1999-01-01

    Analyzes the educational problems and opportunities facing Hertfordshire (England) and the Anglican Diocese of St. Albans. Argues that the anxieties and aspirations of parishes and dioceses within the Church of England influenced the pace and nature of educational developments. Considers the involvement of Bishop Michael Bolton Furse. (CMK)

  10. What I Think I May Have Learned--Reflections on 50 Years of Teaching: An Interview with Michael Wertheimer

    Science.gov (United States)

    Michael, Kurt D.

    2006-01-01

    Kurt Michael is an associate professor in the Department of Psychology at Appalachian State University (ASU) where he teaches history and systems of psychology, abnormal psychology, child psychopathology, and interventions for children and adolescents. He received his BA (cum laude) from the University of Colorado at Boulder and his MS and PhD in…

  11. Michael Novak's "Business as a Calling" as a Vehicle for Addressing Ethical and Policy Concerns in a Business Law Course

    Science.gov (United States)

    Murphy, Tonia Hap

    2008-01-01

    This article describes the author's experience of incorporating Michael Novak's "Business as a Calling: Work and the Examined Life" into a Business Law course. The author views it as a positive addition to the course, one that may be of interest to her colleagues at other institutions. Accordingly, after an overview of Novak's analysis in…

  12. Injectable hyaluronic acid/PEG-p(HPMAm-lac)-based hydrogels dually cross-linked by thermal gelling and Michael addition

    NARCIS (Netherlands)

    Dubbini, Alessandra; Censi, Roberta; Butini, Maria Eugenia; Sabbieti, Maria Giovanna; Agas, Dimitrios; Vermonden, Tina; Di Martino, Piera

    2015-01-01

    Fast in situ forming thermosensitive hydrogels consisted of vinyl sulfone bearing p(HPMAm-lac(1-2))-PEG-p(HPMAm-lac(1-2)) triblock copolymers and thiol modified hyaluronic acid were prepared via a dual cross-linking strategy based on thermal gelation at 37 degrees C and simultaneous Michael addition

  13. Organocatalytic Asymmetric Domino Michael/Henry Reaction of Indolin-3-ones with o-Formyl-β-nitrostyrenes.

    Science.gov (United States)

    Mahajan, Suruchi; Chauhan, Pankaj; Loh, Charles C J; Uzungelis, Server; Raabe, Gerhard; Enders, Dieter

    2015-04-01

    A highly diastereo- and enantioselective domino Michael/Henry reaction of 1-acetylindolin-3-ones with o-formyl-(E)-β-nitrostyrenes catalyzed by low loading of a quinine-derived amine-squaramide provides the corresponding indolin-3-one derivatives bearing four adjacent stereogenic centers in good to high yields and with excellent stereoselectivities.

  14. Komparativistlikke ja kultuuriteaduslikke ärgitusi Baltimaade germanistikale / Michael Schwidtal ; saksa keelest tõlkinud Vahur Aabrams

    Index Scriptorium Estoniae

    Schwidtal, Michael

    2001-01-01

    3. - 5. sept. 2001 toimus Riias sümpoosion "Unter diesem braunen Himmel. Jakob Michael Reinhold Lenz und die deutsche Literatur des Baltikums", 7. - 9. sept. Tartus "Torm ja tung Liivimaal. Mässu mudelid", pühendatud J. M. R. Lenzi ja Kristian Jaak Petersoni loomingule. Ülevaade

  15. Komparativistlikke ja kultuuriteaduslikke ärgitusi Baltimaade germanistikale / Michael Schwidtal ; saksa keelest tõlkinud Vahur Aabrams

    Index Scriptorium Estoniae

    Schwidtal, Michael

    2001-01-01

    3. - 5. sept. 2001 toimus Riias sümpoosion "Unter diesem braunen Himmel. Jakob Michael Reinhold Lenz und die deutsche Literatur des Baltikums", 7. - 9. sept. Tartus "Torm ja tung Liivimaal. Mässu mudelid", pühendatud J. M. R. Lenzi ja Kristian Jaak Petersoni loomingule. Ülevaade

  16. Sight, Sound, and Knowledge: Michael Polanyi's Epistemology as an Attempt to Redress the Sensory Imbalance in Modern Western Thought

    Science.gov (United States)

    Jardine, Murray

    2011-01-01

    The author argues that Michael Polanyi's philosophy of science can be understood as an (unconscious) attempt to recapture elements of experience largely forgotten or repressed in modernity. Specifically, the author argues that Polanyi's epistemology appears to draw on elements of oral-aural experience that have been relatively ignored by the…

  17. HIGHLY DISATEREOSELECTIVE MICHAEL ADDITION OF FLAVANONE TO ITS CHALCONE PRECURSOR UNDER SOLVENT-FREE CONDITIONS USING MICROWAVES [POSTER

    Science.gov (United States)

    Substituted 2'-hydroxychalcones were found to give an equilibrium mixture of the starting chalcone and the corresponding flavanone inf 4.6-1:3 ratio in the presence of DBU gave two hitherto unknown diasteromeric dimers in a highly diastereoselective Michael addition of the carban...

  18. Thomas DaCosta Kaufmann and Michael North (eds., Mediating Netherlandish Art and Material Culture in Asia

    Directory of Open Access Journals (Sweden)

    Claartje Rasterhoff

    2015-12-01

    Full Text Available Book notice of: Thomas DaCosta Kaufmann and Michael North (eds., Mediating Netherlandish Art and Material Culture in Asia (Amsterdam Studies in the Dutch Golden Age Amsterdam, Amsterdam University Press, 2014. 348 pp. ISBN 978-90-8964-569-2. € 99,00.

  19. Michael Byers, International Law and the Arctic (Cambridge: Cambridge Studies in International and Comparative law, Cambridge University Press, 2013

    Directory of Open Access Journals (Sweden)

    Rachael L. Johnstone

    2014-03-01

    Full Text Available A review of: Michael Byers, International Law and the Arctic, Cambridge Studies in International and Comparative law, Cambridge University Press, 2013. pp. 314 + xviii, 65.00 GBP (hardcover; 16.56GBP (kindle edition ISBN: 9781107042759 ISBN: 9781107042759

  20. 78 FR 2391 - CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v. Pacific Gas and...

    Science.gov (United States)

    2013-01-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v... and Procedure of the Federal Energy Regulatory Commission (FERC); CAlifornians for Renewable...

  1. Green Aza-Michael Reaction of Aliphatic Amines to á,(a)-Unsaturated Compounds in Water

    Institute of Scientific and Technical Information of China (English)

    XU Li-Wen; XIA Chun-Gu

    2004-01-01

    The hydroamination of olefins is a long-standing goal for transition metal catalysis. And the metal-catalyzed addition of amines to carbon-carbon double bonds is an unsolved, synthetically important problem. Although recent advances have made using lanthanide and precious metal complexes, there are few excellent catalyst that display broad functional group tolerance and useful rates for an intermolecular aza-Michael addition. As such, the development of efficient synthetic methods leading to a-amino carbonyl compounds and derivatives has attracted much attention in organic synthesis. Although recent advances have made this route more attractive, development of cheaper, simpler, and more efficient metal catalyst is highly desirable. We also have been interested in developing a reaction that uses catalytic quantities of minimally toxic, readily available, economic reagent should greatly contribute to the creation of environmental benign processes.The recent interest in aqueous medium metal-mediated carbon-carbon and carbon-heteroatom and formations led to the contributors for such reactions. Furthermore, development of organic reactions in water will contribute to the progress of green and quasi-nature catalysis chemistry. Surprisingly however, there is few report on conjugate additions of amines to a,a-unsaturated carbonyl compounds in water.Herein, we report a new protocol that employs air stable copper salts as efficient catalyst in the aza-Michael reaction under mild reaction conditions. Advantages of the protocol include high-yielding reactions that can be conducted at ambient temperature; the use of readily available and stable copper salts as the catalyst, and the reaction was successfully performed in environmental benign solvent, water.Finally, we have utilized a variety of aliphatic amines successfully with different á,(a)-unsaturated compounds catalyzed by simple hydrophilic ionic liquid, bmimBF4 in water. Interestingly, all the aliphatic amines gave

  2. An Oral History Interview with MICHAEL M. CERNEA (interviewer: Judith Freidenberg

    Directory of Open Access Journals (Sweden)

    MICHAEL M. CERNEA

    2008-01-01

    Full Text Available The editors and editorial board of Human Organization are pleased to introduce readers to the following oral history interview with Michael M. Cernea, a development social scientist who has militated throughout his academic career and applied work for "putting people first", in the forefront of development projects and policies. Working for a long time for the promotion of anthropological and sociological knowledge, either in the activities of the World Bank or in the policies and programs of governments of both developed and developing countries, Dr. Cernea cleared pathways for applied social science that are sure to benefit people in development settings for many years to come. Undoubtedly many readers already know Dr. Cernea's work well, especially those of us who teach the anthropology of development or work in applied settings and organizations, but this interview embeds his broad body of work into a personal, human, and at times tragic context that opens with brushes with death, Nazi brutality, and exile. It also provides valuable insights for carrying out the work of development anthropologists within large-scale organizations and governments.This interview with Dr. Cernea was conducted by Dr. Judith Freidenberg, of the University of Maryland, on June 30, 2003, for the Society for Applied Anthropology Oral History Project, headquartered at the University of Kentucky Libraries. This Project aims to create, through the vehicle of oral histories, a record of the life, activities and experiences of number of selected scholars-anthropologists who devoted a great part of their scientific work to research, to applied work in different settings, to inducing development, including to hands-on work on crafting public social policies and actual development programs. The present transcript of the interview was reviewed by both participants for editorial purposes. Michael M. Cernea expanded some of his oral responses, for historical accuracy or to add

  3. Entrevista com Mathieu Dosse, Gian Luigi de Rosa e Michael Kegler

    Directory of Open Access Journals (Sweden)

    Andréia Guerini

    2017-09-01

    Full Text Available O conjunto das três entrevistas que seguem aborda a mesma temática, isto é, aspectos de tradução/adaptação em geral e da tradução do romance Estive em Lisboa e lembrei de você de Luiz Ruffato em particular. O romance de Ruffato foi escrito em 2009, editado em Portugal (Quetzal, 2010 e traduzido para diferentes línguas, como italiano (La Nuova Frontiera, 2011, espanhol (Eterna Cadencia, 2011, francês (Chandeigne, 2015, alemão (Assoziation A, 2016 e, nos próximos meses será publicado em finlandês (Into. O livro foi adaptado para o cinema em 2015, pelo cineasta português José Barahona, sendo exibido em festivais nacionais e internacionais. As entrevistas abaixo foram feitas com os tradutores Gian Luigi De Rosa, Mathieu Dosse e Michael Kegler em 2016. Gian Luigi De Rosa (Itália/1969-- possui doutorado em “Culture e Istituzioni dei paesi di lingue iberiche in età moderna e contemporanea” e é professor de português na Universidade do Salento, em Lecce. É autor de livros e ensaios sobre língua e linguística portuguesa, literatura portuguesa e brasileira e tradução audiovisual e intersemiótica. É também responsável pela elaboração das legendas em italiano do filme Estive em Lisboa e lembrei de você. Mathieu Dosse (Brasil/1978-- é formado pela Université Paris 8, onde estudou Teoria da Tradução. Traduziu para o francês Graciliano Ramos, Luiz Ruffato e João Guimarães Rosa. Michael Kegler (Alemanha/1967-- estudou literatura brasileira e portuguesa na universidade de Frankfurt, sem concluir o curso. Trabalhou como livreiro no Centro do Livro de Língua Portuguesa, antes de se tornar tradutor literário. Traduziu para o alemão José Eduardo Agualusa, Moacyr Scliar, Luiz Ruffato, entre outros autores. Em julho de 2016, junto com Ruffato, recebeu o prêmio literário Hermann Hesse na Alemanha, pela qualidade da obra publicada em conjunto com a sua tradução.

  4. Synthesis of the Hemoglobin-Conjugated Polymer Micelles by Thiol Michael Addition Reactions.

    Science.gov (United States)

    Qi, Yanxin; Li, Taihang; Wang, Yupeng; Wei, Xing; Li, Bin; Chen, Xuesi; Xie, Zhigang; Jing, Xiabin; Huang, Yubin

    2016-06-01

    Amphiphilic triblock copolymers mPEG-b-PMAC-b-PCL are synthesized using methoxyl poly(ethylene glycol), cyclic carbonic ester monomer including acryloyl group, and ε-caprolactone. Copolymers are self-assembled into core-shell micelles in aqueous solution. Thiolated hemoglobin (Hb) is conjugated with micelles sufficiently through thiol Michael addition reaction to form hemoglobin nanoparticles (HbNs) with 200 nm in diameter. The conjugation of Hb onto the micelle surface is further confirmed by X-ray photoelectron spectroscopy. Feeding ratio of copolymer micelles to Hb at 1:3 would lead to the highest hemoglobin loading efficiency 36.7 wt%. The UV results demonstrate that the gas transporting capacity of HbNs is well remained after Hb is conjugated with polymeric micelles. Furthermore, the obtained HbNs have no obvious detrimental effects on blood components in vitro. This system may thus have great potential as one of the candidates to be developed as oxygen carriers and provide a reference for the modification of protein drugs.

  5. Michael Jackson, Bin Laden and I: functions of positive and negative, public and private flashbulb memories.

    Science.gov (United States)

    Demiray, Burcu; Freund, Alexandra M

    2015-01-01

    This study examined the perceived psychosocial functions of flashbulb memories: It compared positive and negative public flashbulb memories (positive: Bin Laden's death, negative: Michael Jackson's death) with private ones (positive: pregnancy, negative: death of a loved one). A sample of n = 389 young and n = 176 middle-aged adults answered canonical category questions used to identify flashbulb memories and rated the personal significance, the psychological temporal distance, and the functions of each memory (i.e., self-continuity, social-boding, directive functions). Hierarchical regressions showed that, in general, private memories were rated more functional than public memories. Positive and negative private memories were comparable in self-continuity and directionality, but the positive private memory more strongly served social functions. In line with the positivity bias in autobiographical memory, positive flashbulb memories felt psychologically closer than negative ones. Finally, middle-aged adults rated their memories as less functional regarding self-continuity and social-bonding than young adults. Results are discussed regarding the tripartite model of autobiographical memory functions.

  6. Regression and new beginnings: Michael, Alice and Enid Balint and the circulation of ideas.

    Science.gov (United States)

    Sklar, Jonathan

    2012-08-01

    This article offers a new evaluation of Michael Balint's history. It starts with his growing up in Hungary and examines the central concepts of his writing: the analytic pair, regression and the basic fault and creativity, up to and including his renowned work on the eponymous Balint groups (which forged a unique link between psychoanalysis and medicine). While his name is, of course, well known, this article aims to bring his ideas to the attention of a modern analytic audience. Having trained in the 1920s with Ferenczi, Balint brought Ferenczi's literary inheritance to England where he lived until his death in 1970. His connections to Klein, Winnicott and Lacan, all of whom respected his analytic stance, are also examined. Furthermore, this article argues that his ideas were filtered through the theoretical lens of his first wife Alice Balint and later through Enid Balint, both of whom played a key - and rarely recognised - role in the development of his thought. It ends with a brief discussion of his ideas on analytic training and his quest, successful only after his death, to publish the complete Freud-Ferenczi correspondence, together with Ferenczi's diary. Copyright © 2012 Institute of Psychoanalysis.

  7. Losing Touch: A Theology of Death for Michael Haneke’s Amour

    Directory of Open Access Journals (Sweden)

    Taylor Worley

    2016-11-01

    Full Text Available This proposed theology of death for Michael Haneke’s Amour, a fraught but poignant piece of cinema, will employ Martin Heidegger’s existentialism to reframe the ethical structure of the film and apply a “lived theology” rejoinder to its perceived hopelessness. The proposal will address the question of ethics in relation to Haneke’s cinema, in particular his seemingly nihilistic perspective and confrontational style. To do so, it will revisit the film itself and examine the ways that Georges and Anne’s love is tested. Principally, we examine the film’s great question, which—in the filmmaker’s own words—is: “How do I cope with the suffering of a loved one?” With aid from the theologian Dietrich Bonhoeffer, this ‘lived theology’ proposal will attempt to give an account of love’s irrepressible strength in the midst of even astounding suffering. While Heidegger’s ethic of resoluteness calls for interiority and solitude, Bonhoeffer’s account of death more satisfactorily invokes a transcendent summons contained within our own pledges to loved ones. Such a theological reading of Haneke’s Amour will draw two distinct conclusions: first, the film exposes the superficiality of any hoped-for solitude or escape from a loved one’s death, and secondly, it demonstrates that the mutuality of authentic love entails impossible sacrifices.

  8. Michael Ondaatje's reinvention of social and cultural Myths: In the Skin of a Lion

    Directory of Open Access Journals (Sweden)

    Branko Gorjup

    1989-12-01

    Full Text Available From the beginning of his writing career in the early sixties until the recent publication of In the Skin of a Lian (1987, the Canada of Michael Ondaatje had represented one thing: a geographical locale which he has selected as his home but which, fundamentally, had failed to engage his imagination. The fictional worlds he created in The Collected Works of Billy the Kid, Coming Through Slaughter and Running in the Family, has been located outside of Canada, each corresponding to an actual place complete with historical and geographical references. For this very reason it has been impossible - as Sam Solecki noted in his introduction to Spider Blues, »a collection of reviews and essays on Ondaatje - to place this anomalous literary presence in Canada within »specifically Canadian tradition of writing ...«,  a tradition that would»include and see relationships among figures as different as Roberts, Pratt, F. R. Scott, Purdy and Atwood ...« Ondaatje's »characters, landscapes, stories and themes resist any taxonomies based on overtly Canadian thematics.« In fact, Solecki further suggested that Ondaatje, like »V. S. Naipaul, Derek Walcott and Salmon Rushdie ..., compels a rethinking of the notion of a national tradition«. Similarly, another critic from the same collection described Ondaatje's position in the context of Canadian writing as unique - a position according to which »language or audience or the identity and the role of the poet are indeterminate. «

  9. La figura del libro in Die unendliche Geschichte di Michael Ende: da finestra a varco

    Directory of Open Access Journals (Sweden)

    Elena Di Cesare

    2015-01-01

    Full Text Available The book is an object which can be considered as a window in the novel Die unendliche Geschichte (1979 written by Michael Ende. It allows Bastian to look at the world of Phantasien and to communicate indirectly with the Childlike Empress. Furthermore, this object will show its function as an symbol of evolution, which will enable the passage of the protagonist into the world of Phantasien: first the book appears as a window, then it becomes a two-way-mirror that allows Bastian and Atreju to look at each other, and finally it turns into a gate which enables them to live many adventures together.Die unendliche Geschichte can be considered as a modern Bildungsroman in which the young protagonist gradually reaches his maturation. This progress must be seen in a psychological perspective: it is the growth of a child-mind through literature which makes reference to the German novel tradition but also (as children’s literature to the world of unconsciousness.

  10. Material Culture and Anthropology-An Interview with Anthropologist Michael Rowlands of the University College London

    Institute of Scientific and Technical Information of China (English)

    MICHAEL Rowlands; BIAN Simei; ZHAO Xiuyun

    2014-01-01

    Prof.Michael Rowlands discusses how to use material culture to explore the for-mation and use of objects , the history of objects , and the relationship between objects and histo-ry .He uses examples drawn from his academic background , and his fieldwork done in Africa and China .He further gives an in-depth discussion on the relationship between material culture and anthropology as well as archaeology and anthropology .He proposes specific views on how to de-velop historical anthropology by using material culture , and the combination of archaeology with anthropology .He states that in the future , the focus of anthropology will shift or move away from America and Europe to the rest of the world , and that it is possible that the current understand-ing of anthropology that comes from European and American Anthropology will no longer be ac-cepted as being the truth .Therefore, finding new ways of thinking is necessary for the future de-velopment of anthropology .

  11. Michael Reid Trice, Encountering Cruelty: The Fracture of the Human Heart (Leiden and Boston: Brill, 2011

    Directory of Open Access Journals (Sweden)

    Wendy Hamblet

    2012-03-01

    Full Text Available As many violence scholars, I have not found myself to be greatly interested in cruelty, for the simple reason that instances of cruelty are relatively rare, if we accept its usual definition as “willful indifference to suffering, or taking pleasure in inflicting such suffering upon sentient beings.” Most people do not actively wish harm to others, and for this reason, the harms that keep our societies running smoothly and in ordered fashion must be kept in concealment, far from our direct vision, if we are to be asked to tolerate them—cruel punishments, executions, exclusions of minorities from the full benefits of the society, etc. However, Michael Trice’s new book, Encountering Cruelty, renews a fresh interest in this dark topic by redefining cruelty as an ordinary, common occurrence, infecting the everyday in ever more subtle forms. Trice reveals how a too narrow definition of cruelty may grant us the comfort of believing its occurrence to be minimal, but it robs us of the opportunity to track its traces writ large across the landscape of the human world. We cannot hope to understand, and ultimately heal, the rebounding effects of suffering across the broader social terrain, unless we are willing to admit the cruelty that underlies modern institutional life.

  12. Michael Is Chief Angel?... (A New Theory On “Nephilim”

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    M.Arulmani

    2014-11-01

    Full Text Available Michael” is chief of all Angels?... No… No… No… The “HOLY ADAM” shall be considered as Chief of all Angels. Michael shall mean “FALLEN ANGEL”. This scientific research attempts to clarify certain fundamental questions about Holy Angel, Archangel, Angel of Lord, Fallen Angel based on global level religion, Christian Faith and how “Angel” differs from “Human”. This research focus that the Biblically stated “ADAM” shall be considered as “HOLY ADAM” belong to “ANGEL FAMILY” Human race lived in WHITE PLANET (White Mars before eating “forbidden fruit”, and descended to EARTH PLANET as “Fallen Angels” after eating forbidden fruit. This research further focus that the Angel populations lived in white planet in the early Universe shall be considered as „SUPER HUMAN RACE‟ also called as „NEPHILIM‟. The Nephilim shall be considered as the Natural Human originated due to impact of „J-RADIATION‟ (Zero hour radiation and considered lived under Endothermic and Microgravity environment.

  13. Examination of Michael Dummett’s Anti-Realism and Verificationist Approach

    Directory of Open Access Journals (Sweden)

    a Hossein Khani

    2010-05-01

    Full Text Available Anti-realism was first introduced by Michael Dummett, the contemporary analytic philosopher. He has always preferred to discuss about statements and assertions (instead of entities, such as statements in the past tense, statements about the physical world, and so on. Based on his approach to metaphysical problems, we should initially choose an appropriate model of meaning and a proper conception of the notion of truth applicable to the statements. By doing so, the dispute between realism and anti-realism can be rendered to a disagreement on the kind of meaning the statements may have. After criticizing the realist approach, he goes on to claim that without having proper evidence, we cannot judge on meaning and truth or falsity of linguistic statements. To understand a sentence, Dummett says, is to have the capacity of recognizing what would be counted as evidence for or against it. Therefore, an anti-realist believes that there is no guarantee for every sentence to be certainly true (or false. Or, it cannot be approved for each statement to be necessarily true or false, independently of our knowledge and relevant abilities. An adherent of realism, by contrast, admits the principle of bivalence and acknowledges that sentences are true or false because of the reality existing independently of us. In this essay, after introducing Dummett’s anti-realist approach and his criticisms on realism, I am going to discuss about and explain the correlation between his desired theory of meaning and anti-realism.

  14. Examination of Michael Dummett’s Anti-Realism and Verificationist Approach

    Directory of Open Access Journals (Sweden)

    A. Hossein Khani

    2010-01-01

    Full Text Available Anti-realism was first introduced by Michael Dummett, the contemporary analytic philosopher. He has always preferred to discuss about statements and assertions (instead of entities, such as statements in the past tense, statements about the physical world, and so on. Based on his approach to metaphysical problems, we should initially choose an appropriate model of meaning and a proper conception of the notion of truth applicable to the statements. By doing so, the dispute between realism and anti-realism can be rendered to a disagreement on the kind of meaning the statements may have. After criticizing the realist approach, he goes on to claim that without having proper evidence, we cannot judge on meaning and truth or falsity of linguistic statements. To understand a sentence, Dummett says, is to have the capacity of recognizing what would be counted as evidence for or against it. Therefore, an anti-realist believes that there is no guarantee for every sentence to be certainly true (or false. Or, it cannot be approved for each statement to be necessarily true or false, independently of our knowledge and relevant abilities. An adherent of realism, by contrast, admits the principle of bivalence and acknowledges that sentences are true or false because of the reality existing independently of us. In this essay, after introducing Dummett’s anti-realist approach and his criticisms on realism, I am going to discuss about and explain the correlation between his desired theory of meaning and anti-realism.

  15. Michael Young, the Institute of Community Studies, and the Politics of Kinship.

    Science.gov (United States)

    Butler, Lise

    2015-01-01

    This article examines the East London-based Institute of Community Studies, and its founder, Michael Young, to show that sociology and social research offered avenues for left-wing political expression in the 1950s. Young, who had previously been Head of the Labour Party Research Department during the Attlee government, drew upon existing currents of psychological and sociological research to emphasize the continuing relevance of the extended family in industrial society and to offer a model of socialist citizenship, solidarity and mutual support not tied to productive work. Young and his colleagues at the Institute of Community Studies promoted the supportive kinship networks of the urban working class, and an idealized conception of the relationships between women, to suggest that family had been overlooked by the left and should be reclaimed as a progressive force. The article shows that the Institute's sociological work was informed by a pre-existing concern with family as a model for cooperative socialism, and suggests that sociology and social research should be seen as important sources of political commentary for scholars of post-war politics.

  16. Nacionalismos e internacionalismo: um debate entre Michael Löwy e Michel Cahen

    Directory of Open Access Journals (Sweden)

    Ângela Lazagna

    2008-11-01

    Full Text Available Este artigo consiste em um debate realizado entre Michel Löwy e Michael Cahen em meados dos anos 1990 e revisto para esta publicação. Mesmo que a discussão refira-se a acontecimentos que até certo ponto podem ser considerados datados, a preocupação de fundo que é comum a esses artigos concede-lhes atualidade: a necessidade do aprofundamento de uma reflexão, a partir da teoria marxista, sobre o problema dos nacionalismos e do internacionalismo em tempos de mundialização. Esse aprofundamento, segundo os autores, faz-se necessário sobretudo por meio de uma reflexão que rompa criticamente com uma visão eurocêntrica dos diferentes nacionalismos e que supere a atitude de muitos marxistas de desprezarem tudo aquilo que não seja diretamente relevante à "consciência de classe".

  17. Application of a Double Aza-Michael Reaction in a ‘Click, Click, Cy-Click’ Strategy: From Bench to Flow

    OpenAIRE

    Zang, Qin; Javed, Salim; ULLAH, FARMAN; Zhou, Aihua; Knudtson, Christopher A.; Bi, Danse; Basha, Fatima Z.; Organ, Michael G.; Hanson, Paul R.

    2011-01-01

    The development of a ‘click, click, cy-click’ process utilizing a double aza-Michael reaction to generate functionalized 1,2,5-thiadiazepane 1,1-dioxides is reported. Optimization in flow, followed by scale out of the inter-/intramolecular double aza-Michael addition has also been realized using a microwave-assisted, continuous flow organic synthesis platform (MACOS). In addition, a facile one-pot, sequential strategy employing in situ Huisgen cycloaddition post-double aza-Michael has been ac...

  18. A Tentative Study of English- Chinese Lyric Translation:Illustrated by the Example of Michael Jackson’s Songs

    Institute of Scientific and Technical Information of China (English)

    王若丁

    2013-01-01

      Lyric, as a special form of poetry, its translatability has been a controversial focus among both translators and musicians. This thesis analyzes English-Chinese lyric translation by the illustrations of Michael Jackson’s works based on the references of“equivalent theory”, during which Nida’s arguments about equivalence will be employed. The thesis indicates the important roles which“cultural context”and“personal background”play in the process of lyric translation. With the citing examples of Michael Jackson’s works, this thesis demonstrates the significance of the match of the translated text and the music and the rhythm, and tries to give a better version of lyric translation. The purpose of this thesis is to seek the possibility of the equal performance effect of English-Chinese lyric translation.

  19. [Michael Fischer (1887-1948)--life and work of an important founder of Catholic nursing in Germany].

    Science.gov (United States)

    Kolling, H

    2000-08-01

    In 1919, Michael Fischer OSC was appointed to the German charity union "Zentrale des Deutschen Caritasverbandes" (DCV) in Freiburg. He assumed his duties as the acting manager and general secretary for the German catholic union of health institutions "Verband Katholischer Kranken- und Pflegeanstalten". For nearly twenty years, he was involved in expanding and strengthening this specialized organisation. For more than a decade, Michael Fischer influenced catholic medical care in Germany by holding lectures; on the whole, he published the medical welfare journal "Krankendienst" as well as fifteen specialized books and more than five hundred articles in different journals, which were essential. For all his efforts, his enormous engagement, historical health research has ignored him until now. The following essay is meant to give insight into his life and works and pays tribute to his importance in nursing care.

  20. O que é a Multidão? Questões para Michael Hardt e Antonio Negri

    Directory of Open Access Journals (Sweden)

    Nicholas Brown

    2006-07-01

    Full Text Available Multidão, livro mais recente de Michael Hardt e Antonio Negri, é uma tentativa de nomear e compreender as condições que envolvem a dinâmica social do século xxi. Na entrevista a seguir, Hardt e Negri discorrem sobre as possibilidades de constituição da multidão como agente político, discutem os fundamentos do livro e defendem conceitos que consideram determinantes para a compreensão dos novos tempos, tais como biopolítica e biopoder.Multitude, Michael Hardt and Antonio Negri’s latest book, is an attempt at understanding conditions involving social dynamics in the xxi century. In the interview below, Hardt and Negri consider the constitution of the multitude as a political agent, discuss the structure of their book and support concepts seen as crucial for the comprehension of our time, such as biopolitics and biopower.

  1. “This fabulous flotsam”: Michael Moorcock’s Urban Anthropology in “London under London”

    Directory of Open Access Journals (Sweden)

    Houswitschka Christoph

    2015-07-01

    Full Text Available Michael Moorcock is often described as “one of the most prolific and varied writers working in Britain” (Malcolm 146. His success as a writer and editor of science fiction and fantasy literature is well established, but he is also the author of two novels about London, Mother London (1988 and King of the City (2000. Hardly known, Mother London by Michael Moorcock, offers itself to a variety of approaches that have been widely discussed in the context of studies on English literature during the Thatcher years, post-modernism, and psycho-geography. The novel resonates with the author’s own childhood in war-time London without being autobiographical. It tells the story of three Londoners who were traumatised during the Blitz. The following article focuses on the mysteries of subterranean London that represents the hidden and unconscious identities of its inhabitants in the post-war period.

  2. A study on effect of market orientation and Michael Porter's Five Competitive Forces on performance of Bahman Group

    OpenAIRE

    ahra Mohebi Ashtiani; Sharif karimi

    2016-01-01

    Concept of competitive advantage has a direct linkage with the considered values of the customer, such that the more the supplied values of an organization approach to the considered values of the customer in a comparative range, it can say that the organization outperforms the competitors in one or several competitive criteria. The present research is an applied survey which examines effect of market orientation and Michael Porter's Five Competitive Forces on performance of Bahman Group. ...

  3. Ionic liquid-supported (ILS) (S)-pyrrolidine sulfonamide, a recyclable organocatalyst for the highly enantioselective Michael addition to nitroolefins.

    Science.gov (United States)

    Ni, Bukuo; Zhang, Qianying; Dhungana, Kritanjali; Headley, Allan D

    2009-02-19

    A new class of ionic liquid supported (ILS) (S)-pyrrolidine sulfonamide organocatalyst has been developed and shown to be a very effective catalyst for the asymmetric Michael addition reactions of ketones and aldehyde to nitroolefins with high enantio- and diastereoselectivities. This ILS organocatalyst is also easily recycled and could be reused at least five times without significant loss of its ability to affect the outcome of the asymmetric reactions.

  4. Asymmetric Synthesis of Highly Functionalized Tetrahydropyrans via a One-Pot Organocatalytic Michael/Henry/Ketalization Sequence

    Science.gov (United States)

    Hahn, Robert; Raabe, Gerhard; Enders, Dieter

    2015-01-01

    A diastereo- and enantioselective Michael/Henry/ketalization sequence to functionalized tetrahydropyrans is described. The multicomponent cascade reaction uses acetylacetone or β-keto esters, β-nitrostyrenes, and alkynyl aldehydes as substrates affording tetrahydropyrans with five contiguous stereocenters. Employing a bifunctional quinine-based squaramide organocatalyst, the title compounds are obtained in moderate to good yields (27–80%), excellent enantiomeric excesses (93–99% ee), and high diastereomeric ratios (dr > 20:1) after one crystallization. PMID:24971998

  5. Asymmetric synthesis of functionalized trifluoromethyl-substituted pyrrolidines via an organocatalytic domino Michael/Mannich [3+2] cycloaddition.

    Science.gov (United States)

    Zhi, Ying; Zhao, Kun; Liu, Qiang; Wang, Ai; Enders, Dieter

    2016-11-29

    The asymmetric synthesis of highly functionalized pyrrolidine derivatives with three contiguous stereogenic centers and bearing a trifluoromethyl group has been developed through an organocatalytic domino Michael/Mannich [3+2] cycloaddition sequence. Employing a commercially available secondary amine as the catalyst, the scalable one-pot protocol occurs with high yields and excellent stereoselectivities, providing a short entry into a series of trifluoromethylated pyrrolidines with potential medical value.

  6. In Situ forming poly(ethylene glycol)-based hydrogels via thiol-maleimide Michael-type addition

    OpenAIRE

    Fu, Yao; Kao, Weiyuan John

    2011-01-01

    The incorporation of cells and sensitive compounds can be better facilitated without the presence of UV or other energy sources that are common in the formation of biomedical hydrogels such as poly(ethylene glycol) hydrogels. The formation of hydrogels by the step-growth polymerization of maleimide- and thiol-terminated poly(ethylene glycol) macromers via Michael-type addition is described. The effects of macromer concentration, pH, temperature, and the presence of biomolecule gelatin on gel ...

  7. Highly enantioselective Michael addition of cyclohexanone to nitroolefins catalyzed by pyrrolidine-based bifunctional benzoylthiourea in water.

    Science.gov (United States)

    Wang, Zhen-Yu; Ban, Shu-Rong; Yang, Meng-Chen; Li, Qing-Shan

    2016-11-01

    Organocatalysis and aqueous reactions are identified as the focus of the greening of chemistry. Combining these two strategies effectively remains an interesting challenge in organic synthesis. Herein, we used pyrrolidine-based benzoylthiourea 1c to catalyze the asymmetric Michael addition of cyclohexanone to various nitroolefins in water to afford the corresponding compounds in moderate to good yields, and with excellent diastereoselectivities (up to >99:1 dr) and enantioselectivities (up to 99% ee).

  8. Organocatalytic Asymmetric Synthesis of Functionalized 1,3,5-Triarylpyrrolidin-2-ones via an Aza-Michael/Aldol Domino Reaction.

    Science.gov (United States)

    Joie, Céline; Deckers, Kristina; Enders, Dieter

    2014-03-01

    The organocatalytic asymmetric synthesis of functionalized 1,3,5-triarylpyrrolidin-2-ones bearing three contiguous stereocenters through an aza-Michael/aldol domino reaction of α-ketoamides with α,β-unsaturated aldehydes is described. The domino products were further derivatized by aldehyde olefination under one-pot conditions. The reaction proceeds with excellent diastereoselectivities (>20:1) and good to excellent enantioselectivities (60-96% ee).

  9. Aza-Michael addition reactions between nitroolefins and benzotriazole catalyzed by MCM-41 immobilized heteropoly acids in water

    Institute of Scientific and Technical Information of China (English)

    Shao-Lei Xie; Yong-Hai Hui; Xiang-Ju Long; Chang-Chun Wang; Zheng-Feng Xie

    2013-01-01

    MCM-41 supported heteropoly acids (HPAs) catalysts were synthesized,characterized and their catalytic activity was evaluated in an aza-Michael addition reaction between nitroolefins and benzotriazole in water at room temperature.50 wt% PW/MCM-41 showed the highest activity (up to 96% yield).The catalyst was used in six consecutive experiments without obvious loss of activity,confirming the success of the anchoring process and the catalyst stability.

  10. Creating Shared Value: The One-Trick Pony Approach - A COMMENT ON Michael Porter and Mark Kramer

    OpenAIRE

    Beschorner, Thomas

    2013-01-01

    Although Michael Porter's and Marc Kramer's article "Creating Shared Value" is a welcome attempt to mainstream business ethics among management practitioners, it is neither so radical nor such a departure from standard management thinking as the authors make it seem. Porter's and Kramer's criticism and rejection of corporate social responsibility depends upon a straw man conception of CSR and their ultimate reliance on economic arguments is too normatively thin to do the important work of r...

  11. Fact or Fiction? Colonel Joshua L. Chamberlain at Gettysburg as Depicted in Michael Shaara’s The Killer Angels

    Science.gov (United States)

    1991-01-01

    novel The Broken Place is no longer in print. The book is about a Korean War hero turned prizefighter after the war. The Library Journal of 1 June...a product of Michael Shaara’s creative imagination and is highly recommended by The Library Journal . The Herald is a science fiction account of a...pilot landing and experiencing life in an underpopulated world. The Library Journal states the telegraphic writing is an irritant but is off-set by a

  12. Importance of the nature of α-substituents in pyrrolidine organocatalysts in asymmetric Michael additions.

    Science.gov (United States)

    Patil, Mahendra P; Sharma, Akhilesh K; Sunoj, Raghavan B

    2010-11-05

    The fundamental factors contributing toward the stereoselectivity in organocatalyzed asymmetric Michael reaction between aldehydes (propanal and 3-phenyl propanal) and methyl vinyl ketone (MVK) are established by using density functional theory methods. Three of the most commonly employed α-substituted pyrrolidine organocatalysts are examined. Several key stereochemical modes of addition between (i) a model enamine or (ii) pyrrolidine enamines derived from aldehydes and secondary amine to MVK are examined. Among these possibilities, the addition of (E)-enamine to cis-MVK is found to have a lower activation barrier. The stereochemical outcome of the reaction is reported on the basis of the relative energies between pertinent diastereomeric transition states. Moderate selectivity is predicted for the reaction involving pyrrolidine catalysts I and II, which carry relatively less bulky α-substituents dimethylmethoxymethyl and diphenylmethyl, respectively. On the other hand, high selectivity is computed in the case of catalyst III having a sufficiently large α-substituent (diarylmethoxymethyl or diphenylprolinol methyl ether). The enantiomeric excess in the case of 3-phenyl propanal is found to be much higher as compared to that with unsubstituted propanal, suggesting potential for improvement in stereoselectivity by substrate modifications. The computed enantiomeric excess is found to be in reasonable agreement with the reported experimental stereoselectivities. A detailed investigation on the geometries of the crucial transition states reveals that apart from steric interactions between the α-substituent and MVK, various other factors such as orbital interactions and weak stabilizing hydrogen-bonding interactions play a vital role in stereoselectivity. The results serve to establish the importance of cumulative effects of various stabilizing and destabilizing interactions at the transition state as responsible for the stereochemical outcome of the reaction. The

  13. Corrupting Capitalism: Michael Ende’s Momo and “Cathedral Station”

    Directory of Open Access Journals (Sweden)

    Heike Polster

    2016-01-01

    Full Text Available Michael Ende, the well-known author of The Neverending Story , foresaw dramatic changes in the fabric of society resulting from a turn toward neoliberal policies. One such far-reaching and dangerous change has to do with a diminishing of temporal autonomy, the ability to freely determine the use and meaning of our time. This article explores how neoliberalism is shaping our concept of time and our experience of it. In an effort to demonstrate the process and the line of reasoning behind the monetization of time, and to connect time to more qualitative considerations of the human condition, I shall demonstrate how Ende conceptualizes time as an integral part of the accumulation process of capitalism. I also discuss a fairly cryptic short story, “Cathedral Station,” that envisions “the mystery of money.” Utilizing Walter Benjamin’s critique issued in his 1921 fragment “Capitalism as Religion,” I outline Ende’s dystopian vision of the uncontested, unquestioned reign of capitalism as a religious cult. Read together, the novel and the short story offer a way of contrasting two extreme byproducts of capitalism’s colonization of time, namely what I would call an “ideology of work” and an “ideology of growth.” The first of these is a result of capitalism’s commodification of time according to liberal ideals such as choice, freedom, and self-interest. The second is a decidedly neoliberal phenomenon in that the “financialization of everything,” to use David Harvey’s phrase, results in the ever-present expectation of unlimited, exponential growth. By drawing out these two interconnected ideologies through close readings, the subtle processes of capitalism’s colonization of time are revealed.

  14. Suspense, culpa y cintas de vídeo. Caché/Escondido de Michael Haneke

    Directory of Open Access Journals (Sweden)

    Miguel Martínez-Cabeza

    2011-12-01

    Full Text Available Caché/Escondido (2005 representa dentro de la filmografía de Michael Haneke el ejemplo más destacado de síntesis de los planteamientos formales e ideológicos del cineasta austriaco. Este artículo analiza el filme como manifiesto cinematográfico y como explotación de las convenciones genéricas para construir un modelo de espectador reflexivo. La investigación del modo en que el director plantea y abandona las técnicas del suspense aporta claves para explicar el éxito casi unánime de crítica y la respuesta mucho menos homogénea de las audiencias. El desencadenante de la trama, unas cintas de vídeo que reciben los Laurent, es alusión directa a Carretera Perdida (1997 de David Lynch; no obstante, el misterio acerca del autor de la videovigilancia pierde interés en relación al sentimiento de culpa que desencadena en el protagonista. El episodio infantil de celos y venganza hacia un niño argelino y la actitud del Georges adulto representan una alegoría de la relación de Francia con su pasado colonial que tampoco cierra la narración de Haneke. Es precisamente la apertura formal con que el filme (desestructura cuestiones actuales como el límite entre la responsabilidad individual y colectiva lo que conforma un espectador tan distanciado de la diégesis como consciente de su propio papel de observador.

  15. Functionalization of Polydopamine via the Aza-Michael Reaction for Antimicrobial Interfaces.

    Science.gov (United States)

    Liu, Chia-Yu; Huang, Chun-Jen

    2016-05-17

    Polydopamine (pDA) coatings afford tremendous versatility due to their capabilities to provide substrate-independent functionalization with a wide range of amine- and thiol-containing molecules. In this work, we developed a new and facile conjugation approach to the formation of β-amino carbonyl linkages between pDA and acrylate/acrylamide molecules via the aza-Michael reaction. Sulfobetaine acrylamide (SBAA), sulfobetaine methacrylate (SBMA), and poly(ethylene glycol) methacrylate (PEGMA) were employed to graft onto pDA films, giving rise to formation of antifouling coatings. Because of the universal adhesive property of pDA, the coating strategy was applied to different substrates, including TiO2, gold, SiO2, Nitinol alloy, polystyrene, and poly(dimethylsiloxane). The variation of surface chemistry and surface wettability upon pDA modification and subsequent conjugation was monitored with X-ray photoelectron spectroscopy (XPS) and water contact angle measurements. Antifouling properties of coatings were challenged by three common Gram-negative and Gram-positive bacteria. Cytocompatibility of the coatings with NIH-3T3 fibroblasts was accessed using MTT assay. The results showed that pDA coatings grafted with SBAA exhibited superhydrophilicity and excellent fouling resistance likely due to the high chemical reactivity of acrylamide, leading to high grafting density. In addition, dual functional coatings containing passive and active antibacterial components were constructed through the in situ deposition of antimicrobial agent, silver nanoparticles, in pDA, followed by the grafting of SBAA for bacterial repellence. The composite coatings allowed reducing adsorption of E. coli by >95%, while killing attached bacteria by up to 98% upon the releasing of Ag(+) ions as measured by inductively coupled plasma mass spectrometry. Consequently, this work paves a new avenue to the grafting strategy to engineer pDA and to the functional bioinspired antifouling interfaces in

  16. Solid State Ionics: from Michael Faraday to green energy—the European dimension

    Directory of Open Access Journals (Sweden)

    Klaus Funke

    2013-01-01

    Full Text Available Solid State Ionics has its roots essentially in Europe. First foundations were laid by Michael Faraday who discovered the solid electrolytes Ag2S and PbF2 and coined terms such as cation and anion, electrode and electrolyte. In the 19th and early 20th centuries, the main lines of development toward Solid State Ionics, pursued in Europe, concerned the linear laws of transport, structural analysis, disorder and entropy and the electrochemical storage and conversion of energy. Fundamental contributions were then made by Walther Nernst, who derived the Nernst equation and detected ionic conduction in heterovalently doped zirconia, which he utilized in his Nernst lamp. Another big step forward was the discovery of the extraordinary properties of alpha silver iodide in 1914. In the late 1920s and early 1930s, the concept of point defects was established by Yakov Il'ich Frenkel, Walter Schottky and Carl Wagner, including the development of point-defect thermodynamics by Schottky and Wagner. In terms of point defects, ionic (and electronic transport in ionic crystals became easy to visualize. In an 'evolving scheme of materials science', point disorder precedes structural disorder, as displayed by the AgI-type solid electrolytes (and other ionic crystals, by ion-conducting glasses, polymer electrolytes and nano-composites. During the last few decades, much progress has been made in finding and investigating novel solid electrolytes and in using them for the preservation of our environment, in particular in advanced solid state battery systems, fuel cells and sensors. Since 1972, international conferences have been held in the field of Solid State Ionics, and the International Society for Solid State Ionics was founded at one of them, held at Garmisch-Partenkirchen, Germany, in 1987.

  17. Solid State Ionics: from Michael Faraday to green energy—the European dimension

    Science.gov (United States)

    Funke, Klaus

    2013-01-01

    Solid State Ionics has its roots essentially in Europe. First foundations were laid by Michael Faraday who discovered the solid electrolytes Ag2S and PbF2 and coined terms such as cation and anion, electrode and electrolyte. In the 19th and early 20th centuries, the main lines of development toward Solid State Ionics, pursued in Europe, concerned the linear laws of transport, structural analysis, disorder and entropy and the electrochemical storage and conversion of energy. Fundamental contributions were then made by Walther Nernst, who derived the Nernst equation and detected ionic conduction in heterovalently doped zirconia, which he utilized in his Nernst lamp. Another big step forward was the discovery of the extraordinary properties of alpha silver iodide in 1914. In the late 1920s and early 1930s, the concept of point defects was established by Yakov Il'ich Frenkel, Walter Schottky and Carl Wagner, including the development of point-defect thermodynamics by Schottky and Wagner. In terms of point defects, ionic (and electronic) transport in ionic crystals became easy to visualize. In an ‘evolving scheme of materials science’, point disorder precedes structural disorder, as displayed by the AgI-type solid electrolytes (and other ionic crystals), by ion-conducting glasses, polymer electrolytes and nano-composites. During the last few decades, much progress has been made in finding and investigating novel solid electrolytes and in using them for the preservation of our environment, in particular in advanced solid state battery systems, fuel cells and sensors. Since 1972, international conferences have been held in the field of Solid State Ionics, and the International Society for Solid State Ionics was founded at one of them, held at Garmisch-Partenkirchen, Germany, in 1987. PMID:27877585

  18. Solid State Ionics: from Michael Faraday to green energy-the European dimension.

    Science.gov (United States)

    Funke, Klaus

    2013-08-01

    Solid State Ionics has its roots essentially in Europe. First foundations were laid by Michael Faraday who discovered the solid electrolytes Ag2S and PbF2 and coined terms such as cation and anion, electrode and electrolyte. In the 19th and early 20th centuries, the main lines of development toward Solid State Ionics, pursued in Europe, concerned the linear laws of transport, structural analysis, disorder and entropy and the electrochemical storage and conversion of energy. Fundamental contributions were then made by Walther Nernst, who derived the Nernst equation and detected ionic conduction in heterovalently doped zirconia, which he utilized in his Nernst lamp. Another big step forward was the discovery of the extraordinary properties of alpha silver iodide in 1914. In the late 1920s and early 1930s, the concept of point defects was established by Yakov Il'ich Frenkel, Walter Schottky and Carl Wagner, including the development of point-defect thermodynamics by Schottky and Wagner. In terms of point defects, ionic (and electronic) transport in ionic crystals became easy to visualize. In an 'evolving scheme of materials science', point disorder precedes structural disorder, as displayed by the AgI-type solid electrolytes (and other ionic crystals), by ion-conducting glasses, polymer electrolytes and nano-composites. During the last few decades, much progress has been made in finding and investigating novel solid electrolytes and in using them for the preservation of our environment, in particular in advanced solid state battery systems, fuel cells and sensors. Since 1972, international conferences have been held in the field of Solid State Ionics, and the International Society for Solid State Ionics was founded at one of them, held at Garmisch-Partenkirchen, Germany, in 1987.

  19. Polyphosphoester-Camptothecin Prodrug with Reduction-Response Prepared via Michael Addition Polymerization and Click Reaction.

    Science.gov (United States)

    Du, Xueqiong; Sun, Yue; Zhang, Mingzu; He, Jinlin; Ni, Peihong

    2017-04-26

    Polyphosphoesters (PPEs), as potential candidates for biocompatible and biodegradable polymers, play an important role in material science. Various synthetic methods have been employed in the preparation of PPEs such as polycondensation, polyaddition, ring-opening polymerization, and olefin metathesis polymerization. In this study, a series of linear PPEs has been prepared via one-step Michael addition polymerization. Subsequently, camptothecin (CPT) derivatives containing disulfide bonds and azido groups were linked onto the side chain of the PPE through Cu(I)-catalyzed azidealkyne cyclo-addition "click" chemistry to yield a reduction-responsive polymeric prodrug P(EAEP-PPA)-g-ss-CPT. The chemical structures were characterized by nuclear magnetic resonance spectroscopy, gel permeation chromatography, Fourier transform infrared, ultraviolet-visible spectrophotometer, and high performance liquid chromatograph analyses, respectively. The amphiphilic prodrug could self-assemble into micelles in aqueous solution. The average particle size and morphology of the prodrug micelles were measured by dynamic light scattering and transmission electron microscopy, respectively. The results of size change under different conditions indicate that the micelles possess a favorable stability in physiological conditions and can be degraded in reductive medium. Moreover, the studies of in vitro drug release behavior confirm the reduction-responsive degradation of the prodrug micelles. A methyl thiazolyl tetrazolium assay verifies the good biocompatibility of P(EAEP-PPA) not only for normal cells, but also for tumor cells. The results of cytotoxicity and the intracellular uptake about prodrug micelles further demonstrate that the prodrug micelles can efficiently release CPT into 4T1 or HepG2 cells to inhibit the cell proliferation. All these results show that the polyphosphoester-based prodrug can be used for triggered drug delivery system in cancer treatment.

  20. Diastereoselective Michael Addition of (4'S)-Ethyl-3-(2',2'-Dimethyl-1',3'-dioxolan-4'-yl) acrylate with Furyl Lithium

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Michael addition of the chiral a,b-unsaturated ester 2 with furyl lithium proceeded in syn manner with excellent diastereoselectivity.The diastereoselectivity was not affected by the configuration of the double bond in 2.

  1. Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions.

    Science.gov (United States)

    Jackson, Paul A; Widen, John C; Harki, Daniel A; Brummond, Kay M

    2017-02-09

    Although Michael acceptors display a potent and broad spectrum of bioactivity, they have largely been ignored in drug discovery because of their presumed indiscriminate reactivity. As such, a dearth of information exists relevant to the thiol reactivity of natural products and their analogues possessing this moiety. In the midst of recently approved acrylamide-containing drugs, it is clear that a good understanding of the hetero-Michael addition reaction and the relative reactivities of biological thiols with Michael acceptors under physiological conditions is needed for the design and use of these compounds as biological tools and potential therapeutics. This Perspective provides information that will contribute to this understanding, such as kinetics of thiol addition reactions, bioactivities, as well as steric and electronic factors that influence the electrophilicity and reversibility of Michael acceptors. This Perspective is focused on α,β-unsaturated carbonyls given their preponderance in bioactive natural products.

  2. MICHAEL GORBOVY AS AN ORGANIZER OF THE SCOUTING MOVEMENT IN GUTSULSCHINA (THE BEGINNING OF THE XX CENTURY

    Directory of Open Access Journals (Sweden)

    Iryna Didukh

    2015-04-01

    Full Text Available The Ukrainian scouting movement on western Ukrainian territories reached the highest level during the interwar period. Despite the relative integrity it had its own features in Galicia, Volyn', on Bukovyna, Transcarpathia. As living conditions turned out to be peaceful, old plast centres started to form in schools. "Plast" in Galicia was an example of inheritance and incentive to the development on other western Ukrainian territories and in emigration. The figure of famous Hutsul plastun Michael Gorbovy (1896 – 1941 is very interesting and multidimensional. Indeed, it is a symbolic name in the history of Ukrainian scout organization. He was a member of many national public organizations. With his name economic and cooperative activities of "Plast" in Gutsulschina are connected. He was the organizer of craft departments of "Plast". The unicity of this disjoint person is expressed in his great love for Ukraine and responsibility for its future. Gorbovy considered physical, moral and national-patriotic education of children and youth as his main task. He strived to spread the idea of Ukrainian scouting among wide groups of people. For this work on 22th of May, 1924 he was awarded with a plast title of a scoutmaster. Michael Gorbovy formed national consciousness, high spirituality, love of God and Ukraine among youth for the "great aim" which is to build an independent Ukrainian nation. Experts qualify current spiritual and moral state of the Ukrainian society as "crisis". School is not able to fill the educational vacuum which has appeared after the elimination of the Pioneer and Komsomol organizations. No new alternative children's institutions have been suggested. In such a difficult situation the experience of the activity of the Ukrainian scouting movement may be useful. Creative and practical achievements of "Plast" leaders as key figures and main carriers of the plast's educational methods are especially important. These include a figure of

  3. New eco-friendly animal bone meal catalysts for preparation of chalcones and aza-Michael adducts

    Directory of Open Access Journals (Sweden)

    Riadi Yassine

    2012-06-01

    Full Text Available Abstract Two efficient reactions were successfully carried out using Animal Bone Meal (ABM and potassium fluoride or sodium nitrate doped ABMs as new heterogeneous catalysts under very mild conditions. After preparation and characterization of the catalysts, we first report their use in a simple and convenient synthesis of various chalcones by Claisen–Schmidt condensation and then in an aza-Michael addition involving several synthesized chalcones with aromatic amines. All the reactions were carried out at room temperature in methanol; the chalcone synthesis was also achieved in water environment under microwave irradiation. Doping ABM enhances the rate and yield at each reaction. Catalytic activities are discussed and the ability to re-use the ABM is demonstrated. Results For Claisen–Schmidt the use of ABM alone, yields never exceeded 17%. In each entry, KF/ABM and NaNO3/ABM (79-97% gave higher yields than using ABM alone under thermic condition. Also the reaction proceeded under microwave irradiation in good yields (72-94% for KF/ABM and 81-97% for NaNO3/ABM and high purity. For aza-Michael addition the use of ABM doped with KF or NaNO3 increased the catalytic activity remarkably. The very high yields could be noted (84-95% for KF/ABM and 81-94% for NaNO3/ABM. Conclusion The present method is an efficient and selective procedure for the synthesis of chalcones an aza-Michael adducts. The ABM and doped ABMs are a new, inexpensive and attractive solid supports which can contribute to the development of catalytic processes and reduced environmental problems.

  4. A propósito del libro "Accounting theory: research, regulation and accounting practice" de Michael Gaffikin

    Directory of Open Access Journals (Sweden)

    Garcia Nohora

    2012-09-01

    Full Text Available En el libro “Accounting theory: research, regulation and accounting practice”, el profesor australiano Michael Gaffikin ofrece al lector una idea del origen y amplio desenvolvimiento de la teoría contable durante el siglo XX “cuyo desarrollo ha sido dominado por Estados Unidos” (Gaffikin, 2008, p. 32. Plantea, igualmente, los desafíos y problemas actuales de la regulación y la profesión contable. Por ejemplo, el autor precisa que ante la incapacidad de lograr un acuerdo sobre las mediciones apropiadas, la tendencia mundial es a instaurar medidas determinadas arbitrariamente (Gaffikin, 2008, p. 154.

  5. Michael additions of thiocompounds to {alpha}, {beta}-unsaturated carbonyl compounds in aqueous media: stereoselectivity with unambiguous characterization by NMR

    Energy Technology Data Exchange (ETDEWEB)

    Almeida, Queli Aparecida Rodrigues de; Pereira, Maria Luiza de Oliveira; Coelho, Ricardo Bezerra; Kaiser, Carlos Roland; Jones Junior, Joel; Silva, Flavia Martins da [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Inst. de Quimica. Dept. de Quimica Organica]. E-mail: soa@iq.ufrj.br; Carvalho, Erika Martins de [Instituto de Tecnologia em Farmacos (Far-Manguinhos), Rio de Janeiro, RJ (Brazil)

    2008-07-01

    The reactions of crotonaldehyde (8) with thiophenol (2) and benzalacetone (10) with ethane-1,2- dithiol (11) yield Michael addition products. The reactions of thiophenol (2) with (R)-carvone (13) and (S)-perillaldehyde (15) lead to (2S,3R,5S)-5-isopropenyl-2-methyl-3-(phenylthio)cyclohexanone (14) and (1R,2R,4S)-4-isopropenyl-2-(phenylthio)cyclohexanecarbaldehyde (16), respectively. An unambiguous elucidation of the stereochemistry of 14 and 16 by NMR is also presented. (author)

  6. Highly E-Selective and Enantioselective Michael Addition to Electron-Deficient Internal Alkynes Under Chiral Iminophosphorane Catalysis.

    Science.gov (United States)

    Uraguchi, Daisuke; Yamada, Kohei; Ooi, Takashi

    2015-08-17

    A highly E-selective and enantioselective conjugate addition of 2-benzyloxythiazol-5(4H)-ones to β-substituted alkynyl N-acyl pyrazoles is achieved under the catalysis of a P-spiro chiral iminophosphorane. Simultaneous control of the newly generated central chirality and olefin geometry is possible with a wide array of the alkynyl Michael acceptors possessing different aromatic and aliphatic β-substituents, as well as the various α-amino acid-derived thiazolone nucleophiles. This protocol provides access to structurally diverse, optically active α-amino acids bearing a geometrically defined trisubstituted olefinic component at the α-position.

  7. Advances in Statistical Control, Algebraic Systems Theory, and Dynamic Systems Characteristics A Tribute to Michael K Sain

    CERN Document Server

    Won, Chang-Hee; Michel, Anthony N

    2008-01-01

    This volume - dedicated to Michael K. Sain on the occasion of his seventieth birthday - is a collection of chapters covering recent advances in stochastic optimal control theory and algebraic systems theory. Written by experts in their respective fields, the chapters are thematically organized into four parts: Part I focuses on statistical control theory, where the cost function is viewed as a random variable and performance is shaped through cost cumulants. In this respect, statistical control generalizes linear-quadratic-Gaussian and H-infinity control. Part II addresses algebraic systems th

  8. Kochin, Michael S. 2009. Five Chapters on Rhetoric: Character, Action, Things, Nothing and Art (University Park: Pennsylvania State University Press

    Directory of Open Access Journals (Sweden)

    Eithan Orkibi

    2010-04-01

    Full Text Available Deux constatations traversent le nouvel ouvrage de Michael Kochin, et nous invitent à reconsidérer la rhétorique dans la communication persuasive. D’abord, que ce sont les événements concrets et les faits mis à l’épreuve qui ont la plus grande force de conviction ; et ensuite, que le discours a souvent une fonction autre que la persuasion : celle de maintenir les canaux de communication pour sauvegarder les relations et les institutions humaines. Pour l’auteur de cet ouvrage qui porte sur les...

  9. Studies on NaI/DMSO induced retro-Michael addition (RMA) reactions on some 1,5-dicarbonyl compounds

    Indian Academy of Sciences (India)

    H Surya Prakash Rao; S Jothilingam

    2005-01-01

    Studies on the reaction of some 1,5-ketodiesters/1,5-diketones with NaX (X = Cl/Br/I)/DMSO have shown that under microwave/thermal conditions, facile retro-Michael addition (RMA) reaction takes place instead of formation of the expected Krapcho products. Mechanistic studies have shown that the NaI/DMSO system is a better system than NaCl/DMSO or NaBr/DMSO to promote the RMA pathway and DMSO is an essential requirement. The electrophilic halide ion could be involved in this fragmentation reaction.

  10. Organocatalytic Domino Oxa-Michael/1,6-Addition Reactions: Asymmetric Synthesis of Chromans Bearing Oxindole Scaffolds.

    Science.gov (United States)

    Zhao, Kun; Zhi, Ying; Shu, Tao; Valkonen, Arto; Rissanen, Kari; Enders, Dieter

    2016-09-19

    An asymmetric organocatalytic domino oxa-Michael/1,6-addition reaction of ortho-hydroxyphenyl-substituted para-quinone methides and isatin-derived enoates has been developed. In the presence of 5 mol % of a bifunctional thiourea organocatalyst, this scalable domino reaction affords 4-phenyl-substituted chromans bearing spiro-connected oxindole scaffolds and three adjacent stereogenic centers in good to excellent yields (up to 98 %) and with very high stereoselectivities (up to >20:1 d.r., >99 % ee). © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. QCD propagators and vertices from lattice QCD (in memory of Michael Müller-Preußker)

    Science.gov (United States)

    Sternbeck, André

    2017-03-01

    We review lattice calculations of the elementary Greens functions of QCD with a special emphasis on the Landau gauge. These lattice results have been of interest to continuum approaches to QCD over the past 20 years. They are used as reference for Dyson-Schwinger- and functional renormalization group equation calculations as well as for hadronic bound state equations. The lattice provides low-energy data for propagators and three-point vertices in Landau gauge at zero and finite temperature even including dynamical fermions. We summarize Michael Müller-Preußker's important contributions to this field and put them into the perspective of his other research interests.

  12. ‘Doxographical or Philosophical History of Philosophy: On Michael Frede’s Precepts for Writing the History of Philosophy’

    DEFF Research Database (Denmark)

    Catana, Leo

    2016-01-01

    In a series of articles from the 1980s and 1990s, Michael Frede analysed the history of histories of philosophy written over the last three hundred years. According to Frede, modern scholars have degenerated into what he calls a “doxographical” mode of writing the history of philosophy. Instead, he...... argued, these scholars should write what he called “philosophical” history of philosophy, first established in the last decades of the seventeenth century but since abandoned. In the present article it is argued that Frede’s reconstruction of the history of histories of philosophy is historically...

  13. Michael Faraday: o caminho da livraria à descoberta da indução eletromagnética Michael Faraday: the road from the bookstore to the discovery of electromagnetic induction

    Directory of Open Access Journals (Sweden)

    Valéria Silva Dias

    2004-12-01

    Full Text Available Estudando o trabalho experimental sobre eletromagnetismo realizado por Michael Faraday no início do século XIX, encontramos vários elementos que poderiam ser utilizados no Ensino de Ciências. Um conhecimento histórico sobre o trabalho experimental desenvolvido por Faraday e que o levou à descoberta da indução eletromagnética pode transmitir aos estudantes uma concepção mais adequada do processo de desenvolvimento da Ciência. No entanto, isso só pode ser feito utilizando-se um estudo detalhado e bem fundamentado do processo histórico ocorrido, deixando de lado as simplificações e os mitos que costumam ser apresentados.The study of Michael Faraday's experimental research on electromagnetism developed in the early 19th century provides several components which could be used in Science Teaching. A historical knowledge of the experimental work that led Faraday to the discovery of electromagnetic induction may convey to students a more adequate process of the development of science. However, this can only be done by the use of a detailed and well grounded study of the historical process, leaving aside the naïve simplifications and the myths that are usually told.

  14. Quantitative First-Principles Kinetic Modeling of the Aza-Michael Addition to Acrylates in Polar Aprotic Solvents.

    Science.gov (United States)

    Desmet, Gilles B; D'hooge, Dagmar R; Omurtag, Pinar Sinem; Espeel, Pieter; Marin, Guy B; Du Prez, Filip E; Reyniers, Marie-Françoise

    2016-12-16

    This work presents a detailed computational study and kinetic analysis of the aza-Michael addition of primary and secondary amines to acrylates in an aprotic solvent. Accurate rate coefficients for all elementary steps in the various competing mechanisms are calculated using an ONIOM-based approach in which the full system is calculated with M06-2X/6-311+G(d,p) and the core system with CBS-QB3 corrected for solvation using COSMO-RS. Diffusional contributions are taken into account using the coupled encounter pair model with diffusion coefficients calculated based on molecular dynamics simulations. The calculated thermodynamic and kinetic parameters for all forward and reverse elementary reactions are fed to a microkinetic model giving excellent agreement with experimental data obtained using GC analysis. Rate analysis reveals that for primary and secondary amines, the aza-Michael addition to ethyl acrylate occurs preferentially according to a 1,2-addition mechanism, consisting of the pseudoequilibrated formation of a zwitterion followed by a rate controlling amine assisted proton transfer toward the singly substituted product. The alternative 1,4-addition becomes competitive if substituents are present on the amine or double bond of the acrylate. Primary amines react faster than secondary amines due to increased solvation of the zwitterionic intermediate and less sterically hindered proton transfer.

  15. Refined transition-state models for proline-catalyzed asymmetric Michael reactions under basic and base-free conditions.

    Science.gov (United States)

    Sharma, Akhilesh K; Sunoj, Raghavan B

    2012-12-07

    The stereocontrolling transition state (TS) models for C-C bond formation relying on hydrogen bonding have generally been successful in proline-catalyzed aldol, Mannich, α-amination, and α-aminoxylation reactions. However, the suitability of the hydrogen-bonding model in protic and aprotic conditions as well as under basic and base-free conditions has not been well established for Michael reactions. Through a comprehensive density functional theory investigation, we herein analyze different TS models for the stereocontrolling C-C bond formation, both in the presence and absence of a base in an aprotic solvent (THF). A refined stereocontrolling TS for the Michael reaction between cyclohexanone and nitrostyrene is proposed. The new TS devoid of hydrogen bonding between the nitro group of nitrostyrene and carboxylic acid of proline, under base-free conditions, is found to be more preferred over the conventional hydrogen-bonding model besides being able to reproduce the experimentally observed stereochemical outcome. A DBU-bound TS is identified as more suitable for rationalizing the origin of asymmetric induction under basic reaction conditions. In both cases, the most preferred approach of nitrostyrene is identified as occurring from the face anti to the carboxylic acid of proline-enamine. The predicted enantio- and diastereoselectivities are in very good agreement with the experimental observations.

  16. J.M. Coetzee’s Life and Times of Michael K and Foe as Postmodernist Allegories

    Directory of Open Access Journals (Sweden)

    L. O’Connell

    1989-05-01

    Full Text Available J.M. Coetzee is een van die kontemporêre skrywers vir wie postmodernistiese allegoric ’n bruikbare metafoor geword het. Sy verhale karteer die geaardheid, implikasies en gevolge van die misbruik van mag, en die mite van kolonialisme word ontleed en onthul. Life and Times of Michael K kan op die universele sowel as op die spesifiek Suid-Afrikaanse vlak geinterpreteer word. Michael K word die simbool van die mens se persoonlike vryheid, persoonlike identiteit en waardigheid. Sy stryd om vryheid is ironies in die lig van die feit dat die oorlog waaraan hy probeer ontkom, geveg word juis om minderheidsgroepe inspraak in hulle toekoms te verseker. Foe ondersoek die verhouding van vertelling en gebeure, waarheid en fiksie. Friday se stilte word ’n manifestasie van die eksistensiële niet. Soos dit in hierdie roman ontplooi, is dit die taak van die skrywer om die gemeenskap aan homself te openbaar, sodat die spraaklose weer resonasie gegee word.

  17. Optimum Conditions for Introducing Free Radical Polymerizable Methacrylate Groups on the MWCNT Surface by Michael Addition Reaction

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sunghoon; Park, Seonghwan; Kwon, Jaebeom; Ha, KiRyong [Keimyung University, Daegu (Korea, Republic of)

    2015-02-15

    In this study, we investigated optimum conditions for the introduction of a lot of free radical polymerizable methacrylate groups on the multi-walled carbon nanotube (MWCNT) surface. Carboxyl groups were introduced first on MWCNT surfaces by treating with a mixture of sulfuric acid and nitric acid with ultrasonic bath for 2 hours, and oxidized MWCNTs were reacted further with thionyl chloride followed by triethylenetetramine (TETA) to introduce amino groups on the oxidized MWCNT surface, to make MWCNT-NH{sub 2}. To introduce free radical polymerizable methacrylate groups on the MWCNT-NH{sub 2}, MWCNT-NH{sub 2} was reacted with 3-(acryloyloxy)-2-hydroxypropyl methacrylate (AHM) by Michael addition reaction. We investigated progress of modification reactions for MWCNT by fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and elemental analysis (EA). We found maximum degree of Michael addition reactions between AHM and TETA grafted on MWCNT-NH{sub 2} for 10:1 mol ratio and 8 hour reaction time in our reaction conditions.

  18. Asymmetric Sequential Aza-Diels-Alder and O-Michael Addition: Efficient Construction of Chiral Hydropyrano[2,3-b]pyridines%Asymmetric Sequential Aza-Diels-Alder and O-Michael Addition: Efficient Construction of Chiral Hydropyrano[2,3-b]pyridines

    Institute of Scientific and Technical Information of China (English)

    尹祥; 圊清清; 董琳; 陈应春

    2012-01-01

    An asymmetric aza-Diels-Alder and O-Michael addition sequence has been developed to construct chiral hy- dropyrano[2,3-b]pyridine derivatives with good yields and excellent stereoselectivity, by starting with N-Ts-l-aza- 1,3-butadienes and aliphatic aldehydes tethered to an α,β-unsaturated ketone motif. A tandem O-Michael addition reaction was completed via acid catalysis.

  19. G2特别通告:十字魔琴无影手 MICHAEL ANGELO即将君临中国

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正> 2003年,Michael Angelo被世界著名吉他杂志《Guitar One》评选为全世界速度最快的吉他手,杂志是如此介绍:世界上最快的手指Michael Angelo——号称批着人皮的机器!谁要是认为自己身体机能已达到弹琴绝无问题了,那就错了。因为还有“Michael Angelo牌弹琴机”。任何看了他弹琴的人都觉得琴已经没什么弹头了,他弹的东西只适合那些臂力持久的人,

  20. Asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes of glycine Schiff bases. Part 3: Michael addition reactions and miscellaneous transformations.

    Science.gov (United States)

    Aceña, José Luis; Sorochinsky, Alexander E; Soloshonok, Vadim

    2014-09-01

    The major goal of this review is a critical discussion of the literature data on asymmetric synthesis of α-amino acids via Michael addition reactions involving Ni(II)-complexes of amino acids. The material covered is divided into two conceptually different groups dealing with applications of: (a) Ni(II)-complexes of glycine as C-nucleophiles and (b) Ni(II)-complexes of dehydroalanine as Michael acceptors. The first group is significantly larger and consequently subdivided into four chapters based on the source of stereocontrolling element. Thus, a chiral auxiliary can be used as a part of nucleophilic glycine Ni(II) complex, Michael acceptor or both, leading to the conditions of matching vs. mismatching stereochemical preferences. The particular focus of the review is made on the practical aspects of the methodology under discussion and mechanistic considerations.

  1. "They don´t care about us!" : Aftonbladets och Dagens Nyheters framställning av Michael Jackson bortgång

    OpenAIRE

    2010-01-01

    Den 25 juni 2009 dog en av världens mest kända artister, Michael Jackson. Detta orsakade stora rubriker i massmedierna och fans över hela världen sörjde. Denna uppsats handlar om hur Michael Jacksons bortgång framställdes i av de största tidningarna i Sverige, Aftonbladet och Dagens Nyheter. Vi formulerade följande frågeställningar: Hur framställs och vinklas Michael Jacksons bortgång i Aftonbladet respektive Dagens Nyheter? I vad mån skiljer sig framställningen och vinklingen mellan de båda...

  2. L’impérialisme humanitaire de Michael Ignatieff : le cas d’un « liberal hawk » Michael Ignatieff’s “Humanitarian Imperialism”: The case of a “liberal hawk”

    Directory of Open Access Journals (Sweden)

    Pierre Guerlain

    2009-10-01

    Full Text Available Michael Ignatieff, a former Harvard professor who is now active in Canadian politics, represents a school of thought which may be called humanitarian imperialism or liberal imperialism whose most famous representative in Europe is Bernard Kouchner. He argues for US interventions in the world (Kosovo, Afghanistan, Iraq on account of UN weakness and unwillingness to stop massacres or genocides. In his calls for the US to assume this new burden, Ignatieff mentions all the arguments usually invoked against empires and imperialism only to reject them in a rhetorical twist. He is one of the most articulate advocates of military intervention with a clear conscience. Though he often ends up in agreement with neoconservative or neoliberal imperialists his justifications are more intellectual and convoluted and therefore address a different audience.

  3. Chiral-at-Metal Rh(III) Complex-Catalyzed Decarboxylative Michael Addition of β-Keto Acids with α,β-Unsaturated 2-Acyl Imidazoles or Pyridine.

    Science.gov (United States)

    Li, Shi-Wu; Gong, Jun; Kang, Qiang

    2017-03-17

    A newly prepared chiral-at-metal Rh(III) complex-catalyzed, highly efficient enantioselective decarboxylative Michael addition of β-keto acids with α,β-unsaturated 2-acyl imidazoles or pyridine has been developed, affording the corresponding adducts in 94-98% yield with up to 96% enantioselectivity. This protocol exhibits remarkable reactivity, as the complex with a Rh(III) loading as low as 0.05 mol % can catalyze the decarboxylative Michael addition on a gram scale without loss of enantioselectivity.

  4. A dual arylboronic acid--aminothiourea catalytic system for the asymmetric intramolecular hetero-Michael reaction of α,β-unsaturated carboxylic acids.

    Science.gov (United States)

    Azuma, Takumi; Murata, Akihiro; Kobayashi, Yusuke; Inokuma, Tsubasa; Takemoto, Yoshiji

    2014-08-15

    A bifunctional aminoboronic acid has been used to facilitate for the first time the intramolecular aza- and oxa-Michael reactions of α,β-unsaturated carboxylic acids. The combination of an arylboronic acid with a chiral aminothiourea allowed for these reactions to proceed successfully in an enantioselective manner to afford the desired heterocycles in high yields and ee's (up to 96% ee). The overall utility of this dual catalytic system was demonstrated by a one-pot enantioselective synthesis of (+)-erythrococcamide B, which proceeded via sequential Michael and amidation reactions.

  5. A simple protocol for the michael addition of indoles with electron deficient olefins catalysed by TBAHS in aqueous media and their broad spectrum antibacterial activity

    Indian Academy of Sciences (India)

    M Damodiran; R Senthil Kumar; P M Sivakumar; Mukesh Doble; Paramasivan T Perumal

    2009-01-01

    Tetrabutylammonium hydrogen sulfate catalysed addition of indoles to electron deficient olefins in water generated the corresponding Michael adducts in good to excellent yield. The Michael addition of indole occurred regioselectively at position 3 and the -alkylated products have not been observed. The synthesized compounds were tested for their antibacterial activity against four microorganisms namely, E. coli NCIM 2931, S. aureus NCIM 5021, P. vulgaris NCIM 2813, P. aeruginosa NCIM 5029 by micro dilution method. These compounds showed MIC (Minimum Inhibitory Concentration) values in the range of 0.16-2.67 M.

  6. Theoretical and Experimental Investigation of Thermodynamics and Kinetics of Thiol-Michael Addition Reactions: A Case Study of Reversible Fluorescent Probes for Glutathione Imaging in Single Cells.

    Science.gov (United States)

    Chen, Jianwei; Jiang, Xiqian; Carroll, Shaina L; Huang, Jia; Wang, Jin

    2015-12-18

    Density functional theory (DFT) was applied to study the thermodynamics and kinetics of reversible thiol-Michael addition reactions. M06-2X/6-31G(d) with the SMD solvation model can reliably predict the Gibbs free energy changes (ΔG) of thiol-Michael addition reactions with an error of less than 1 kcal·mol(-1) compared with the experimental benchmarks. Taking advantage of this computational model, the first reversible reaction-based fluorescent probe was developed that can monitor the changes in glutathione levels in single living cells.

  7. ‘Introducing Michael Gove to Loïc Wacquant’: Why Social Work Needs Critical Sociology

    Science.gov (United States)

    Michael Garrett, Paul

    2016-01-01

    In 2013, Michael Gove, then Secretary of State for Education and Health in the UK coalition government, criticised social workers for laying insufficient emphasis on the ‘agency’ of individuals and for being too preoccupied with social and economic inequalities. Such a perspective, which is not unique to Gove, needs to be countered by reaffirming the significance of an expansively critical sociology for social work. In this context, the thematic concerns of the French theorist, Loïc Wacquant, illuminates key aspects of social work engagement with clients which Gove and his ideological associates appear intent on ignoring. The issues raised have significant political resonances given the pending UK General Election taking place in May 2015. PMID:27559203

  8. Enzyme-catalyzed Michael addition for the synthesis of warfarin and its determination via fluorescence quenching of L-tryptophan

    Science.gov (United States)

    Yuan, Yusheng; Yang, Liu; Liu, Shaopu; Yang, Jidong; Zhang, Hui; Yan, Jingjing; Hu, Xiaoli

    2017-04-01

    A sensitive fluorescence sensor for warfarin was proposed via quenching the fluorescence of L-tryptophan due to the interaction between warfarin and L-tryptophan. Warfarin, as one of the most effective anticoagulants, was designed and synthesized via lipase from porcine pancreas (PPL) as a biocatalyst to catalyze the Michael addition of 4-hydroxycoumarin to α, β-unsaturated enones in organic medium in the presence of water. Furthermore, the spectrofluorometry was used to detect the concentration of warfarin with a linear range and detection limit (3σ/k) of 0.04-12.0 μmol L- 1 (R2 = 0.994) and 0.01 μmol L- 1, respectively. Herein, this was the first application of bio-catalytic synthesis and fluorescence for the determination of warfarin. The proposed method was applied to determine warfarin of the drug in tablets with satisfactory results.

  9. Michael-type addition reactions for the in situ formation of poly(vinyl alcohol)-based hydrogels.

    Science.gov (United States)

    Tortora, Mariarosaria; Cavalieri, Francesca; Chiessi, Ester; Paradossi, Gaio

    2007-01-01

    Michael-type addition reactions offer the possibility to obtain in situ formation of polymeric hydrogels in the absence of a radical mechanism for the networking process. We explored such a synthetic route for obtaining a poly(vinyl alcohol) (PVA)-based hydrogel as a potential biomaterial for applications in vitro-retinal replacement surgery. The presence of radicals in the reaction medium can represent a risk for in situ surgical treatment. To circumvent this problem we have applied nucleophilic addition to ad hoc modified PVA macromers. The gel formation has been studied with respect to the timing required in this surgery and in terms of the structural characteristics of the obtained network.

  10. Stereoselective Michael Addition of Glycine Anions to Chiral Fischer Alkenylcarbene Complexes. Asymmetric Synthesis of beta-Substituted Glutamic Acids.

    Science.gov (United States)

    Ezquerra, Jesús; Pedregal, Concepción; Merino, Isabel; Flórez, Josefa; Barluenga, José; García-Granda, Santiago; Llorca, María-Amparo

    1999-09-03

    The reaction of lithium enolates of achiral N-protected glycine esters with chiral alkoxyalkenylcarbene complexes of chromium provided the corresponding Michael adducts with either high anti or syn selectivity depending on the nature of the nitrogen protecting group, and high diastereofacial selectivity when carbene complexes containing the (-)-8-phenylmenthyloxy group were employed. Subsequent oxidation of the metal-carbene moiety followed by deprotection of the amine group and hydrolysis of both carboxylic esters afforded enantiomerically enriched 3-substituted glutamic acids of natural as well as unnatural stereochemistry. Alternatively, when the deprotection step was performed previously to the oxidation, cyclic aminocarbene complexes were formed, which finally led to optically active 3-substituted pyroglutamic acids.

  11. A New Strategy for Enantioselective Construction of Multisubstituted Five-Membered Oxygen Heterocycles via a Domino Michael/Hemiketalization Reaction.

    Science.gov (United States)

    Hua, Yuan-Zhao; Liu, Meng-Meng; Huang, Pei-Jin; Song, Xixi; Wang, Min-Can; Chang, Jun-Biao

    2015-08-17

    A new highly enantioselective domino Michael/hemiketalization reaction of α-hydroxyacetophenone with β,γ-unsaturated α-keto esters for the synthesis of 2,2,4,5-tetrasubstituted chiral tetrahydrofurans is reported. With 2 mol % intramolecular dinuclear zinc-AzePhenol complex prepared in situ from the reaction of multidentate semi-azacrown ether ligand with ZnEt2 , the corresponding anti-multisubstituted tetrahydrofuran products were obtained in up to 90 % yields, and 98 % enantiomeric excess (ee) at 0 °C for 45 min. Moreover, the products were easily converted to 2,3,5-trisubstituted 2,3-dihydrofurans without any loss in optical activity. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. One-pot organocatalytic enantioselective Michael/Povarov domino strategy for the construction of spirooctahydroacridine-3,3'-oxindole scaffolds.

    Science.gov (United States)

    Wu, Hao; Wang, Yong-Mei

    2014-05-12

    An asymmetric organocatalytic one-pot strategy for the construction of spirooctahydroacridine-3,3'-oxindole scaffolds has been successfully developed by means of a domino Michael/Povarov reaction sequence. The one-pot protocol affords the chiral spirocyclohexaneoxindoles bearing an octahydroacridine motif with five stereocenters in good to high yields (up to 89 % yield) with excellent to perfect diastereoselectivities (up to >20:1 d.r.) and enantioselectivities (up to >99 % ee). This highly efficient one-pot domino procedure will allow diversity-oriented syntheses of this intriguing class of compounds with potential biological activities. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Azevedo Amaral e o século do corporativismo, de Michael Manoilesco, no Brasil de Vargas

    Directory of Open Access Journals (Sweden)

    Angela de Castro Gomes

    2012-11-01

    Full Text Available Este artigo tem como objetivo de fundo acompanhar o processo de circulação e apropriação de ideias sobre o modelo corporativista de organização do Estado e da sociedade, no Brasil dos anos 1930/40. Para tanto, escolheu trabalhar com a atuação de um dos mais importantes intelectuais desse período: Azevedo Amaral. Este intelectual se dedicou a traduzir para o português, o livro de Michael Manoilesco, O século do corporativismo, do qual escreve o prefácio, em 1938. Nos anos 1930, produz também vários livros, entre os quais, O Estado autoritário e a realidade nacional, igualmente datado de 1938 e publicado pela editora José Olympio, no qual faz uma aposta imediata no modelo autoritário e corporativista de Estado para o Brasil.

  14. QCD propagators and vertices from lattice QCD (in memory of Michael Müller-Preußker

    Directory of Open Access Journals (Sweden)

    Sternbeck André

    2017-01-01

    Full Text Available We review lattice calculations of the elementary Greens functions of QCD with a special emphasis on the Landau gauge. These lattice results have been of interest to continuum approaches to QCD over the past 20 years. They are used as reference for Dyson-Schwinger- and functional renormalization group equation calculations as well as for hadronic bound state equations. The lattice provides low-energy data for propagators and three-point vertices in Landau gauge at zero and finite temperature even including dynamical fermions. We summarize Michael Müller-Preußker’s important contributions to this field and put them into the perspective of his other research interests.

  15. Switchable Diastereoselectivity in the Fluoride Promoted Vinylogous Mukaiyama-Michael Reaction of 2-Trimethylsilyloxyfuran Catalyzed by Crown Ethers

    KAUST Repository

    Della Sala, Giorgio

    2017-05-31

    The fluoride promoted vinylogous Mukaiyama-Michael reaction (VMMR) of 2-trimethylsilyloxyfuran with diverse α,β-unsaturated ketones is described. The TBAF catalyzed VMMR afforded high anti-diastereoselectivity irrespective of the solvents used. The KF/crown ethers catalytic systems proved to be highly efficient in terms of yields and resulted in a highly diastereoselective unprecedented solvent/catalyst switchable reaction. Anti-adducts were obtained as single diastereomers or with excellent diastereoselectivities when benzo-15-crown-5 in CH2Cl2 was employed. On the other hand, high syn-diastereoselectivities (from 76:24 to 96:4) were achieved by employing dicyclohexane-18-crown-6 in toluene. Based on DFT calculations, the catalysts/solvents-dependent switchable diastereoselectivities are proposed to be the result of loose or tight cation-dienolate ion pairs.

  16. Cinema e cinismo: distorções performativas e fruições contemporâneas em Michael Haneke

    Directory of Open Access Journals (Sweden)

    Feitoza, Frederico Antonio Cordeiro

    2010-01-01

    Full Text Available Neste artigo parto da ideia de que Michael Haneke em A fita branca (Das Wiesse band, 2009 realiza distorções performativas a partir de modos cínicos de enunciação ancorados sensivelmente por uma perspectiva historicista para compor sua usual distribuição sádica de saber. Ao abordar o tema de uma geração que provavelmente se tornaria parte da juventude hitlerista, o filme expõe personagens e situações cujas formas de vida pressupõem uma naturalização germânica do mal, ao mesmo tempo em que, a partir de um jogo de sugestões, não se compromete com esta mesma tese, o que contribui para a qualidade enigmática do filme e para a confusão do espectador

  17. Nitro-fatty acid reaction with glutathione and cysteine. Kinetic analysis of thiol alkylation by a Michael addition reaction.

    Science.gov (United States)

    Baker, Laura M S; Baker, Paul R S; Golin-Bisello, Franca; Schopfer, Francisco J; Fink, Mitchell; Woodcock, Steven R; Branchaud, Bruce P; Radi, Rafael; Freeman, Bruce A

    2007-10-19

    Fatty acid nitration by nitric oxide-derived species yields electrophilic products that adduct protein thiols, inducing changes in protein function and distribution. Nitro-fatty acid adducts of protein and reduced glutathione (GSH) are detected in healthy human blood. Kinetic and mass spectrometric analyses reveal that nitroalkene derivatives of oleic acid (OA-NO2) and linoleic acid (LNO2) rapidly react with GSH and Cys via Michael addition reaction. Rates of OA-NO2 and LNO2 reaction with GSH, determined via stopped flow spectrophotometry, displayed second-order rate constants of 183 M(-1)S(-1) and 355 M(-1)S(-1), respectively, at pH 7.4 and 37 degrees C. These reaction rates are significantly greater than those for GSH reaction with hydrogen peroxide and non-nitrated electrophilic fatty acids including 8-iso-prostaglandin A2 and 15-deoxy-Delta(12,14)-prostaglandin J2. Increasing reaction pH from 7.4 to 8.9 enhanced apparent second-order rate constants for the thiol reaction with OA-NO2 and LNO2, showing dependence on the thiolate anion of GSH for reactivity. Rates of nitroalkene reaction with thiols decreased as the pKa of target thiols increased. Increasing concentrations of the detergent octyl-beta-d-glucopyranoside decreased rates of nitroalkene reaction with GSH, indicating that the organization of nitro-fatty acids into micellar or membrane structures can limit Michael reactivity with more polar nucleophilic targets. In aggregate, these results reveal that the reversible adduction of thiols by nitro-fatty acids is a mechanism for reversible post-translational regulation of protein function by nitro-fatty acids.

  18. Facile construction of macroporous hybrid monoliths via thiol-methacrylate Michael addition click reaction for capillary liquid chromatography.

    Science.gov (United States)

    Lin, Hui; Ou, Junjie; Liu, Zhongshan; Wang, Hongwei; Dong, Jing; Zou, Hanfa

    2015-01-30

    A facile approach based on thiol-methacrylate Michael addition click reaction was developed for construction of porous hybrid monolithic materials. Three hybrid monoliths were prepared via thiol-methacrylate click polymerization by using methacrylate-polyhedral oligomeric silsesquioxane (POSS) (cage mixture, n=8, 10, 12, POSS-MA) and three multi-thiol crosslinkers, 1,6-hexanedithiol (HDT), trimethylolpropane tris(3-mercaptopropionate) (TPTM) and pentaerythritol tetrakis(3-mercaptopropionate) (PTM), respectively, in the presence of porogenic solvents (n-propanol and PEG 200) and a catalyst (dimethylphenylphosphine, DMPP). The obtained monoliths possessed high thermal and chemical stabilities. Besides, they all exhibited high column efficiencies and excellent separation abilities in capillary liquid chromatography (cLC). The highest column efficiency could reach ca. 195,000N/m for butylbenzene on the monolith prepared with POSS-MA and TPTM (monolith POSS-TPTM) in reversed-phase (RP) mode at 0.64mm/s. Good chromatographic performance were all achieved in the separations of polycyclic aromatic hydrocarbons (PAHs), phenols, anilines, EPA 610 as well as bovine serum albumin (BSA) digest. The high column efficiencies in the range of 51,400-117,000N/m (achieved on the monolith POSS-PTM in RP mode) convincingly demonstrated the high separation abilities of these thiol-methacrylate based hybrid monoliths. All the results demonstrated the feasibility of the phosphines catalyzed thiol-methacrylate Michael addition click reaction in fabrication of monolithic columns with high efficiency for cLC applications. Copyright © 2014 Elsevier B.V. All rights reserved.

  19. Rumaluse marss Afganistanis / Jaswant Singh ; tõlkinud Priit Simson

    Index Scriptorium Estoniae

    Singh, Jaswant

    2010-01-01

    India endine välisminister on seisukohal, et Afganistani tungimine rajanes väärarvestusel. Seda maad on võimalik ehk mõneks ajaks okupeerida, kuid ainult ajutiselt. Tähtis on leppida sellega, et Afganistani pole võimalik keskselt valitseda, vaid ainult juhendada

  20. Eesti vajab kiiresti euroabi vastuvõtmise kava / Rupinder Singh

    Index Scriptorium Estoniae

    Singh, Rupinder

    2003-01-01

    Autor leiab, et EL-i liikmelisus annab võimaluse püsivaks ja õiglaseks majanduskasvu koefitsiendiks, kuid vaid juhul, kui potentsiaalsed võimalused ära kasutatakse. Ta rõhutab tugeva poliitilise juhtimise ja strateegilise planeerimise vajalikkust valmistamaks ette infrastruktuuri EL-i rahade kasutamiseks. Samas pole Baltimaades tema hinnangul hetkel isegi piisavalt inimesi EL-i finantsvoogude suure potentsiaaliga tegelemiseks.

  1. Mandibular Fractures at Veer Chandra Singh Garhwali Government ...

    African Journals Online (AJOL)

    Mandibular fractures constitute a substantial proportion of cases of maxillofacial ... facial injury that the average practicing dental surgeon may expect to encounter. .... anterior, left and right lateral oblique, panoramic and computed tomography. Simple ... Table 4 shows the relation of fracture site to cause of the mandibular ...

  2. Women in fish farming and gender perspectives | Singh | Nigerian ...

    African Journals Online (AJOL)

    Open Access DOWNLOAD FULL TEXT ... In fish farming, women are actively involved in production and other important activities like catching, cleaning, ... must be developed for successful operation and popularization of fishery activities.

  3. Retropharyngeal cold abscess without Pott's spine | Singh | South ...

    African Journals Online (AJOL)

    Retropharyngeal cold abscess without Pott's spine. ... pyogenic osteomyelitis, tube‚rculosis of the spine, or external injuries caused by endoscopes ... in an adult woman without tuberculosis of the cervical spine who was managed surgically by ...

  4. Enantioselective Cu-II-Catalyzed Diels-Alder and Michael Addition Reactions in Water Using Bio-Inspired Triazacyclophane-Based Ligands

    NARCIS (Netherlands)

    Albada, H. Bauke; Rosati, Fiora; Coquiere, David; Roelfes, Gerard; Liskamp, Rob M. J.

    2011-01-01

    A triazacyclophane (TAC) scaffold decorated with three histidine amino acid residues was used as a tridentate ligand in asymmetric copper(II)-catalysed Diels-Alder and Michael addition reactions in water. Enantiomeric excesses up to 55% were obtained in Diels-Alder reactions using ligands in which t

  5. What's in a Name? That Which We Call a Crisis? A Commentary on Michael Young's Article "Overcoming the Crisis in Curriculum Theory"

    Science.gov (United States)

    Lundgren, Ulf P.

    2015-01-01

    Michael Young's article "Overcoming the crisis in curriculum theory: a knowledge-based approach" ("JCS, 45", 2) is discussed from the starting point that the claimed crisis is constructed from a decisive solution, that is the solution determines what is a crisis. But curriculum research and curriculum theory are in need of…

  6. What We Know about Adolescents' Out-of-School Literacies, What We Need to Learn, and Why Studying Them Is Important: An Interview with Michael W. Smith

    Science.gov (United States)

    Smith, Michael W.; Moore, David W.

    2012-01-01

    Michael W. Smith, a professor in Temple University's College of Education, focuses his research on how experienced readers read and talk about texts as well as what motivates adolescents' reading and writing in and out of school. He sees the recent research on adolescents' out-of-school literacies as a challenge to literacy educators to look at…

  7. Using Our Voices, Losing Our Bodies: Michael Brown, Trayvon Martin, and the Spirit Murders of Black Male Professors in the Academy

    Science.gov (United States)

    Johnson, Lamar; Bryan, Nathaniel

    2017-01-01

    The recent deaths of Michael Brown, Trayvon Martin, and other Black males have generated new civil rights urgencies in Black communities and spirited academic discourses in higher education regarding the educational and social plight of Black males in America. Connecting the deaths of Black males to our lived experiences in the academy, we use a…

  8. Synthesis of new pyrrolidine-based organocatalysts and study of their use in the asymmetric Michael addition of aldehydes to nitroolefins

    Directory of Open Access Journals (Sweden)

    Alejandro Castán

    2017-03-01

    Full Text Available New pyrrolidine-based organocatalysts with a bulky substituent at C2 were synthesized from chiral imines derived from (R-glyceraldehyde acetonide by diastereoselective allylation followed by a sequential hydrozirconation/iodination reaction. The new compounds were found to be effective organocatalysts for the Michael addition of aldehydes to nitroolefins and enantioselectivities up to 85% ee were achieved.

  9. LEBANON AFTER THE CEDAR REVOLUTION/ARE KNUDSEN AND MICHAEL KERR (eds; LEBANON: A HISTORY, 600--2011/by WILLIAM HARRIS

    Directory of Open Access Journals (Sweden)

    Franck Salameh

    2013-05-01

    Full Text Available LEBANON AFTER THE CEDAR REVOLUTION, ARE KNUDSEN AND MICHAEL KERR (eds; London: C. Hurst & Company, 2012. 323 pp. $29.95. LEBANON: A HISTORY, 600--2011, WILLIAM HARRIS; Oxford, New York: Oxford University Press, 2012. 360 pp. $34.95.

  10. Tandem halogenation/Michael-initiated ring-closing reaction of α,β-unsaturated nitriles and activated methylene compounds: one-pot diastereoselective synthesis of functionalized cyclopropanes.

    Science.gov (United States)

    Xin, Xiaoqing; Zhang, Qian; Liang, Yongjiu; Zhang, Rui; Dong, Dewen

    2014-04-21

    An efficient one-pot synthetic route to highly substituted cyclopropanes has been developed from readily available α,β-unsaturated nitriles and doubly activated methylene compounds under very mild conditions in a highly diastereoselective manner, which involves halogenation, Michael addition and intramolecular ring-closing reaction sequences.

  11. The cultural evolution of language and brain: Comment on "Towards a Computational Comparative Neuroprimatology: Framing the language-ready brain" by Michael A. Arbib

    Science.gov (United States)

    Colagè, Ivan

    2016-03-01

    Michael A. Arbib's Mirror System Hypothesis (MSH) [1,2] is among the most elaborate attempts at disentangling the issue of language origin. I will focus on the role that cultural evolution, as distinct from biological (genetic) evolution, may have played in the emergence of "modern" human language (as contrasted with forms of proto-languages).

  12. What We Know about Adolescents' Out-of-School Literacies, What We Need to Learn, and Why Studying Them Is Important: An Interview with Michael W. Smith

    Science.gov (United States)

    Smith, Michael W.; Moore, David W.

    2012-01-01

    Michael W. Smith, a professor in Temple University's College of Education, focuses his research on how experienced readers read and talk about texts as well as what motivates adolescents' reading and writing in and out of school. He sees the recent research on adolescents' out-of-school literacies as a challenge to literacy educators to look at…

  13. Basic-functionalized recyclable ionic liquid catalyst: A solvent-free approach for Michael addition of 1,3-dicarbonyl compounds to nitroalkenes under ultrasound irradiation.

    Science.gov (United States)

    Narayanaperumal, Senthil; da Silva, Rodrigo César; Feu, Karla Santos; de la Torre, Alexander Fernández; Corrêa, Arlene G; Paixão, Márcio Weber

    2013-05-01

    A task-specific ionic liquid (TSIL) has been introduced as a recyclable catalyst in Michael addition. A series of nitroalkenes and various C-based nucleophiles were reacted in the presence of 30mol% of recyclable basic-functionalized ionic liquid. Good to excellent yields were obtained in 30min under ultrasound irradiation.

  14. A novel chiral aliphatic-aromatic diamine promoted direct, highly enantio- and diastereoselective Michael addition of cyclohexanone to nitroolefins under solvent-free conditions.

    Science.gov (United States)

    Miao, Shifeng; Bai, Jinjin; Yang, Jin; Zhang, Yawen

    2010-10-01

    A series of new highly efficient chiral aliphatic-aromatic diamine catalysts have been designed and successfully applied to the asymmetric Michael addition of cyclohexanone with nitroolefins under solvent-free conditions without any acidic additives. The desired adducts were obtained in high yields with excellent enantio- and diastereoselectivities of syn products (up to >99% ee, >99:1 dr).

  15. Using Our Voices, Losing Our Bodies: Michael Brown, Trayvon Martin, and the Spirit Murders of Black Male Professors in the Academy

    Science.gov (United States)

    Johnson, Lamar; Bryan, Nathaniel

    2017-01-01

    The recent deaths of Michael Brown, Trayvon Martin, and other Black males have generated new civil rights urgencies in Black communities and spirited academic discourses in higher education regarding the educational and social plight of Black males in America. Connecting the deaths of Black males to our lived experiences in the academy, we use a…

  16. Gallium(III)- and calcium(II)-catalyzed Meyer-Schuster rearrangements followed by intramolecular aldol condensation or endo-Michael addition.

    Science.gov (United States)

    Presset, M; Michelet, B; Guillot, R; Bour, C; Bezzenine-Lafollée, S; Gandon, V

    2015-03-28

    The first gallium- and calcium-catalyzed Meyer-Schuster rearrangements are described. Under substrate control, the incipient conjugated ketones can be trapped intramolecularly by β-keto esters or amides to yield cyclic products after aldol condensation or endo-Michael addition. An interesting additive effect that promotes the latter tandem process with calcium has been found.

  17. Synthesis and evaluation of new guanidine-thiourea organocatalyst for the nitro-Michael reaction: Theoretical studies on mechanism and enantioselectivity

    Directory of Open Access Journals (Sweden)

    Tatyana E. Shubina

    2012-09-01

    Full Text Available A new guanidine-thiourea organocatalyst has been developed and applied as bifunctional organocatalyst in the Michael addition reaction of diethyl malonate to trans-β-nitrostyrene. Extensive DFT calculations, including solvent effects and dispersion corrections, as well as ab initio calculations provide a plausible description of the reaction mechanism.

  18. Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents.

    Science.gov (United States)

    Zheng, Suqing; Santosh Laxmi, Y R; David, Emilie; Dinkova-Kostova, Albena T; Shiavoni, Katherine H; Ren, Yanqing; Zheng, Ying; Trevino, Isaac; Bumeister, Ronald; Ojima, Iwao; Wigley, W Christian; Bliska, James B; Mierke, Dale F; Honda, Tadashi

    2012-05-24

    Novel monocyclic cyanoenones examined to date display unique features regarding chemical reactivity as Michael acceptors and biological potency. Remarkably, in some biological assays, the simple structure is more potent than pentacyclic triterpenoids (e.g., CDDO and bardoxolone methyl) and tricycles (e.g., TBE-31). Among monocyclic cyanoenones, 1 is a highly reactive Michael acceptor with thiol nucleophiles. Furthermore, an important feature of 1 is that its Michael addition is reversible. For the inhibition of NO production, 1 shows the highest potency. Notably, its potency is about three times higher than CDDO, whose methyl ester (bardoxolone methyl) is presently in phase III clinical trials. For the induction of NQO1, 1 also demonstrated the highest potency. These results suggest that the reactivity of these Michael acceptors is closely related to their biological potency. Interestingly, in LPS-stimulated macrophages, 1 causes apoptosis and inhibits secretion of TNF-α and IL-1β with potencies that are higher than those of bardoxolone methyl and TBE-31.

  19. Direct Asymmetric Michael Additions of Ketones to Nitroolefins and Chalcones Catalyzed by a Chiral C2-Symmetric Pyrrolidine-based Tetraamine

    Institute of Scientific and Technical Information of China (English)

    马世俊; 吴璐璐; 刘明; 王永梅

    2012-01-01

    C2-Symmetric pyrrolidine-based tetraamine, available from commercially starting materials, showed good cata- lytic activity for asymmetric Michael additions of ketones to nitroalkenes especially to chalcones. The reactions proceeded to give the corresponding products in good yields and in a highly selective manner.

  20. Self-Formation and Transformative Learning: A Response to "Calling Transformative Learning into Question--Some Mutinous Thoughts," by Michael Newman

    Science.gov (United States)

    Dirkx, John M.

    2012-01-01

    This article presents the author's response to Michael Newman's "Calling Transformative Learning into Question: Some Mutinous Thoughts". Transformative learning has arguably become one of the most generative and provocative ideas in adult learning. More than 30 years ago, Mezirow (1978) introduced this idea to the field of adult education. During…

  1. Enantioselective Cu-II-Catalyzed Diels-Alder and Michael Addition Reactions in Water Using Bio-Inspired Triazacyclophane-Based Ligands

    NARCIS (Netherlands)

    Albada, H. Bauke; Rosati, Fiora; Coquiere, David; Roelfes, Gerard; Liskamp, Rob M. J.

    A triazacyclophane (TAC) scaffold decorated with three histidine amino acid residues was used as a tridentate ligand in asymmetric copper(II)-catalysed Diels-Alder and Michael addition reactions in water. Enantiomeric excesses up to 55% were obtained in Diels-Alder reactions using ligands in which

  2. Translation and interpretation of Michael Sadowsky's paper "Theory of elastically bendable inextensible bands with applications to the M\\"obius band"

    CERN Document Server

    Hinz, Denis F

    2014-01-01

    This article is a translation of Michael Sadowsky's original paper "Theorie der elastisch biegsamen undehnbaren B\\"ander mit Anwendungen auf das M\\"obiussche Band" in 3. internationaler Kongress f\\"ur technische Mechanik, Stockholm, 1930. The translation is augmented by an Appendix containing an interpretation of the last section of Sadowsky's original paper including figures generated from recent numerical simulations.

  3. Un-catalyzed tandem Knoevenagel-Michael reaction for the synthesis of 4,4'-(arylmethylene)bis(7H-pyrazol-5-ols) in aqueous medium

    Institute of Scientific and Technical Information of China (English)

    Nilesh P. Tale; Girdharilal B. Tiwari; Nandkishor N. Karade

    2011-01-01

    An environmentally benign un-catalyzed one-pot synthesis of 4,4'-(arylmethylene)bis(7H-pyrazol-5-ols) has been reported via tandem Knoevenagel-Michael reaction of aldehydes with two equivalents of 3-methyl-l-phenyl-lH-pyrazol-5(4H)-one in aqueous medium.

  4. Preparation of a Rapidly Forming Poly(ferrocenylsilane)-Poly(ethylene glycol)-based Hydrogel by a Thiol–Michael Addition Click Reaction

    NARCIS (Netherlands)

    Sui, Xiaofeng; van Ingen, Lennard; Hempenius, Mark A.; Vancso, Gyula J.

    2010-01-01

    The synthesis of a rapidly forming redox responsive poly(ferrocenylsilane)-poly(ethylene glycol) (PFS-PEG)-based hydrogel is described, achieved by a thiol-Michael addition click reaction. PFS bearing acrylate side groups (PFS-acryl) was synthesized by side group modification of

  5. Asymmetric synthesis of cyclopentanes bearing four contiguous stereocenters via an NHC-catalyzed Michael/Michael/esterification domino reaction† †Electronic supplementary information (ESI) available: Experimental procedures and characterization date (NMR, IR, MS, HPLC). CCDC 1437686. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5cc09581f Click here for additional data file. Click here for additional data file.

    Science.gov (United States)

    Shu, Tao; Ni, Qijian; Song, Xiaoxiao; Zhao, Kun; Wu, Tianyu; Puttreddy, Rakesh; Rissanen, Kari

    2016-01-01

    An NHC-catalyzed Michael/Michael/esterification domino reaction via homoenolate/enolate intermediates for the asymmetric synthesis of tetrasubstituted cyclopentanes bearing four contiguous stereocenters is described. A variety of α,β-unsaturated aldehydes and 2-nitroallylic acetates react well with good domino yields and high stereoselectivities. PMID:26750327

  6. Successful treatment of mild to moderate acne vulgaris with Dr Michaels® (also branded as Zitinex®) topical products family: a clinical trial.

    Science.gov (United States)

    Wollina, U; Tirant, M; Bayer, P; Coburn, M; Anderson, P; Donnelly, B; Kennedy, T; Gaibor, J; Arora, M; Clews, L; Walmsley, S; Hercogovấ, J; Fioranelli, M; Gianfaldoni, S; Chokoeva, A A; Tchernev, G; Novotny, F; Roccia, M G; Maximov, G K; França, K; Lotti, T

    2016-01-01

    Acne vulgaris is an epidemic inflammatory skin disease of multi-factorial origin, frequently seen in adolescents and often persisting or occurring through to adulthood. Acne vulgaris is a nearly universal skin disease afflicting 79-95% of the adolescent population in westernized societies and is a significant cause of psychological morbidity in affected patients. Despite the various treatment options available for acne, there is still a need for a safe and effective option. The aim of the study was to investigate the efficacy and tolerability of Dr Michaels® (Zitinex®) product family in the treatment of papulo-pustular acne. 25 patients (17 female/8 male), aged 15-22, with a mild to moderate papulo-pustular acne, localized on the face and on the trunk, were included in this study. None of the patients had used any other kind of treatment in the 3 months prior to commencing this study. All of the patients were treated with Dr Michaels® (Zitinex®) facial exfoliating cleanser, activator formula, a cream, PSC 200 and PSC 900 oral supplements. Application time of Dr Michaels® (Zitinex®) products was 12 weeks. The treatment was been evaluated clinically at 0, 4, 8 and 12 weeks. All of the patients showed an improvement in all parameters of their acne (comedones, papules, pustules, hyperpigmentation and scars). The acne lesions and erythema had mostly resolved. The hyperpigmentation and pitted scarring had significantly reduced also, with the skin appearing smoother. The treatment was well tolerated and no side effects have been described. Our study demonstrates that the Dr Michaels® (Zitinex®) facial exfoliating cleanser, activator formula, cream and oral supplements PSC 200 and PSC 900 are an effective therapeutic option for the treatment of moderately severe acne vulgaris. Moreover, it highlights the safety profile of the Dr Michaels® (Zitinex®) product family in a case of acne compared to traditional first-line treatments.

  7. Cadrage, décadrage et recadrage dans Baa Baa Black Sheep : A Jungle Tale de David Malouf et Michael Berkeley Patrimonial Deconstruction and Reconstruction in David Malouf and Michael Berkeley’s Baa Baa Black Sheep : A Jungle Tale

    Directory of Open Access Journals (Sweden)

    Jean-Philippe Héberlé

    2011-11-01

    Full Text Available This article discusses Michael Berkeley’s first opera, Baa Baa Black Sheep: A Jungle Tale. Premiered under the baton of Paul Daniel on July 3rd 1993 at the Cheltenham International Festival of Music, this opera is based on two texts by Rudyard Kipling: The Jungle Books (1894-1895 and “Baa, Baa, Black Sheep” from the short story collection Wee Willie Winkie and Other Stories, first published in 1888. The libretto was penned by the Australian poet, novelist, playwright and librettist, David Malouf. After a brief survey of some of the earliest transpositions of The Jungle Books, I analyse the way David Malouf deals with both texts. “Baa Baa Black Sheep” is used as the central element of his libretto, and episodes and characters from The Jungle Books are incorporated to draw parallelism between the main topics of the two texts. Both Malouf’s endeavour and Berkeley’s, through the music, aims at deconstructing the preposterous oldest transpositions of The Jungle Books and at focusing on the key elements of Kipling’s famous book, notably identity and hybridism, two important themes of colonial and postcolonial literature. The aim of David Malouf and Michael Berkeley is to address an adult audience and show that The Jungle Books are not only aimed at children as Disney’s or Baden Powell’s appropriations of the work could wrongly make us believe.Cet article porte sur Baa Baa Black Sheep: A Jungle Tale, le premier opéra de Michael Berkeley. Créé au Everyman Theatre de Cheltenham le 3 juillet 1993 sous la direction de Paul Daniel, cette œuvre est le fruit de la collaboration entre le compositeur britannique et l’écrivain australien David Malouf. Le livret de Malouf se fonde sur deux récits de Rudyard Kipling : la nouvelle autobiographique “Baa, Baa, Black Sheep” auquel l’opéra doit son nom et The Jungle Books. Après m’être intéressé aux premières transpositions musicales de The Jungle books, je montre comment

  8. El movimiento como simulacro en el mundo virtual: Michael Betancourt y el arte de la inmediatez. = Movement as simulacrum in the virtual world: Michael Betancourt and the art of immediacy

    Directory of Open Access Journals (Sweden)

    José Manuel García Perera

    2016-05-01

    Full Text Available La creación artística se ha acercado en los últimos tiempos a la imagen mediática que propone Internet, alterando sustancialmente una experiencia estética antes basada en el movimiento del espectador en torno a la obra y definida ahora por pantallas que inducen a la pasividad. El trabajo en vídeo de Michael Betancourt, encuadrado en el denominado arte glitch, ese que se fija en el fallo ocurrido dentro del ámbito digital, ha sido la base para realizar aquí un estudio comparativo entre diferentes concepciones artísticas del movimiento, así como entre un arte pasado y otro actual que permite ver cómo los avances tecnológicos han originado cambios radicales en la naturaleza corpórea, espacial y móvil de la obra. La investigación de Betancourt propone un nuevo arte cinético que, por medio del error, se hace crítico, se mimetiza con el movimiento en tiempo real que la contemporaneidad demanda y destapa el artificio de imágenes que imitan a la realidad como si quisieran sustituirla.In recent times, artistic creation has come closer to the media image proposed by Internet, thus seriously altering an aesthetic experience based before on movement of the viewer around the work and now defined by screens that induce passivity. Michael Betancourt’s video work, part of the so-called glitch art, which focuses on the failure that can occur within the digital realm, has been here the basis for a comparative study between different concepts of movement in art, as well as between a current and a past art, a comparison that allows us to see clearly how technological advances have produced radical changes in the physical, spatial and mobile nature of the artwork. Betancourt’s investigation proposes a new kinetic art that becomes critical through error, mimics the real-time movement that contemporary culture demands, and uncovers the artificiality of images that mimic reality as if they wanted to replace it.

  9. LIMITES E CONTRADIÇÕES DO DESENVOLVIMENTO EM MICHAEL PORTER: POSSIBILIDADES EM OMAR AKTOUF E MILTON SANTOS

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    COSTA, César Renato Ferreira da

    2016-04-01

    Full Text Available Desenvolvimento, no campo dos estudos/práticas organizacionais, tem se articulado como um conceito/ação fundamental atualmente. Tomado em função do paradigma dominante, propõe um objetivo ampliado: estabelecer referência para a aproximação da atividade produtiva das corporações com a sociedade. Assim, a partir da confrontação teórica crítica (BOURDÉ; MARTIN, 1983; HOBSBAWM, 1998 buscou-se analisar o tema, enquanto articulação ideológica, baseada no pensamento de Michael Porter pela ênfase desenvolvimentista, em contraposição com as ideias de Aktouf (2004 e Santos (2010 identificando então implicações, limites e contradições deste modelo hegemônico. Tais considerações tornam premente a necessidade de que, se de fato, existe uma nova preocupação, capaz de redirecionar o conceito de desenvolvimento, como está apregoada em ações sociais e ambientais, tanto em empresas, quanto em arestas da sociedade, não pode estar atrelada às premissas do modelo de competitividade dominante. Development in the field organizational of studies/practices, has been articulated as a key concept/action currently. Taken as a function of the dominant paradigm, proposes an expanded goal: to establish reference for approaching the productive activity of corporations to society. Thus, from the theoretical critical confrontation (BOURDE; MARTIN, 1983; HOBSBAWM, 1998 we attempted to analyze the theme, while ideological articulation, based on the thought of Michael Porter for developmental emphasis, in contrast with the ideas of Aktouf (2004 and Santos (2010 so identifying implications, limitations and contradictions of the hegemonic model. Such considerations make urgent the need, if indeed, there is a new concern, able to redirect the concept of development, as is proclaimed in social and environmental actions, both in companies and in edges of society, can not be tied to dominant assumptions of the competitive model.

  10. Examples of weathering and deterioration of Tertiary building stones at St. Michaels Cathedral in Cluj-Napoca (Romania

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    Roman Koch

    2008-10-01

    Full Text Available St. Michaels Cathedral is one of the oldest Gothic architectural monuments in Cluj. It is built predominantly of Cenozoic (Eocene limestones which were deposited on a shallow carbonate platform. They are composed of different facies and microfacies types with varying amounts of particles, matrix and cement. Limestones from the Baci quarry (Cluj Limestone, which is situated about 3 km from the centre of Cluj, were commonly used. The weathering features correspond to the microfacies types, to the position of the stones in the walls and to the exposure (east, south, west, and north, which controls the moisture/dry cycles. This interrelationship is documented by macroscopic and microscopic examples of the decay of samples analyzed from the lower part of the walls. General parameters for a correct classification of carbonate rocks and their importance for weathering are discussed. The general mechanisms of weathering (thermal expansion, water uptake, freezing, chemical weathering are described. The migration of moisture (capillarity and the formation of crusts of varying mineralogy on the surface of building stones are documented. Macroscopic description of damage includes the decay into plates and flakes, the formation of crusts, the formation of fractures, and the growth of lichens and microorganisms. The microscopic analysis documents characteristic damage in detail: fractures parallel to the surface of the stone, internal cementation of fossil chambers (micro-nodules, repeated formation of crusts in varying generations, fracturing in intensively lithified, rigid limestones, and settling of lichens in different positions. Furthermore, different historical mortars and modern “concrete-mortars” and their behaviour in comparison to the adjacent limestones are briefly discussed. The possible conservation and restoration of weathered limestones in St. Michaels Cathedral are discussed with regard to the most recent conservation methods. The

  11. Research Progress in the Environmentally-Friendly Michael Addition%环境友好型Michael加成的研究进展

    Institute of Scientific and Technical Information of China (English)

    李志峰; 侯海亮; 应安国; 许松林

    2014-01-01

    Michael加成反应是有机合成领域一类非常重要的反应。随着人们环保意识的增强和对绿色化学研究的深入,环境友好型Michael加成取得了诸多成功。综述了近5年来离子液体、酶催化、负载固相催化、聚乙二醇(PEG)等参与的Michael 加成反应的研究进展。着重分析了反应体系的高效性、催化剂可能的催化反应机理以及催化剂的循环使用性,并以此对环境友好型Michael加成的发展做出了展望。%Michael addition is one kind of important reaction in the organic field. With the enhancement of environmental awareness and the depth of green chemistry research, environmentally-friendly Michael addition has made many successes. The research progress over the past 5 years in the Michael addition involving ionic liquids, enzyme catalysis, solid phase sup-ported catalysis and polyethylene glycol (PEG) is reviewed. This paper is consisted of six parts, focusing on the efficiency of the reaction system, the probable catalytic mechanism and the recycle of the catalyst. In the first part, a brief introduction is given. Then the Michael addition used the ionic liquid as catalyst or/and solvent is elaborated. In this part, acidic ionic liquid, basic ionic liquids and chiral ionic liquid are described, respectively. As a mild catalyst, enzymes are described in the third part. The solid phase supported catalysis has been used in many reaction without exception to Michael addition. So, in the fourth part, the catalysts of polymer supported, silica-supported and superparamagnetic nano supported are stated. Following, the successful use of polyethylene glycol (PEG) as a green solvent is presented. Finally, the conclusion, the existing problems of these green technologies and the prospect are summarized.

  12. Guerras Justas e Injustas Michael Walzer: Uma Argumentação Moral com Exemplos Históricos

    Directory of Open Access Journals (Sweden)

    Romualdo Santos Monteiro

    2017-02-01

    Full Text Available O presente artigo pretende abordar a questão da moralidade nas guerras justas e injustas de Michael Walzer. Como se processa o comportamento das autoridades perante as guerras, as batalhas, os embates. Os procedimentos tomados em cada peleja por seus líderes analisado minuciosamente por Walzer. Esse pensador trata dos aspectos mais utilizados pelos realistas no que diz respeito ao agir antes, durante e após a guerra. Num segundo momento Walzer trata da realidade e da moral. Como se estruturam estas duas categorias num estado de guerra. Será tratado do relativismo histórico e, em especial, a visão hobbesiana como pressuposto de um estado de guerra. Um terceiro tópico a ser debatido será o crime de guerra. Em que circunstâncias poderá ser considerada a guerra como uma causa justa? Quais as circunstâncias que a tornam injusta? Haverá um momento em que a guerra torna-se um inferno devido o grau de atrocidades e não tem mais volta. Num tópico final, Walzer trata das normas de guerra. Ele utilizará de alguns exemplos de combates para fundamentar sua tese sobre a normatividade da guerra.

  13. A study on effect of market orientation and Michael Porter's Five Competitive Forces on performance of Bahman Group

    Directory of Open Access Journals (Sweden)

    ahra Mohebi Ashtiani

    2016-12-01

    Full Text Available Concept of competitive advantage has a direct linkage with the considered values of the customer, such that the more the supplied values of an organization approach to the considered values of the customer in a comparative range, it can say that the organization outperforms the competitors in one or several competitive criteria. The present research is an applied survey which examines effect of market orientation and Michael Porter's Five Competitive Forces on performance of Bahman Group. The present research is an applied survey in which the questionnaire was used as the data collection instrument. In this research, the indices were detected after studying the books and articles and interviewing with the experts. The research hypotheses were designed based on these criteria. Ultimately, all the hypotheses were confirmed using statistical techniques. After inferential analysis of data which includes significant study on the items of the questionnaire regarding the factors, the study on the relationship between latent and patent variables was considered. The research hypotheses and the modeling for the relationship between dependent and independent variables were confirmed using structural equation method and ultimately all the proposed hypotheses were confirmed.

  14. From defining antigens to new therapies in multiple sclerosis: honoring the contributions of Ruth Arnon and Michael Sela.

    Science.gov (United States)

    Steinman, Lawrence; Shoenfeld, Yehuda

    2014-11-01

    Ruth Arnon and Michael Sela profoundly influenced the development of a model system to test new therapies in multiple sclerosis (MS). Their application of the animal model, known as experimental autoimmune encephalomyelitis (EAE), for the discovery of Copaxone, opened a new path for testing of drug candidates in MS. By measuring clinical, pathologic, and immunologic outcomes, the biological implications of new drugs could be elucidated. Using EAE they established the efficacy of Copaxone as a therapy for preventing and reducing paralysis and inflammation in the central nervous system without massive immune suppression. This had a huge impact on the field of drug discovery for MS. Much like the use of parabiosis to discover soluble factors associated with obesity, or the replica plating system to probe antibiotic resistance in bacteria, the pioneering research on Copaxone using the EAE model, paved the way for the discovery of other therapeutics in MS, including Natalizumab and Fingolimod. Future applications of this approach may well elucidate novel therapies for the neurodegenerative phase of multiple sclerosis associated with disease progression.

  15. DELİLİĞE ÖVGÜ: MICHAEL CHEVAL’İN SARAY SOYTARISI METAFORUNA KARNAVALESK YAKLAŞIM

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    Duygu Ozakin

    2012-08-01

    Full Text Available The folly as a cultural phenomenon plays a symbolic role in social acceptances and art. Reflections of folly in language enable semiotic analysis; however language of fools independent from causuality reverses this interaction benefiting from freedom raised by folly. The relationship established by mental and physical deformations and grotesque appearance between fools and jesters, mimes, jugglers deigns these humiliated groups “Feast of Fools” as a purification ritual in the Middle Ages. However with the Age of Enlightenment a great passion for rationality leads to the idea of capture and rehabilitation of fools.In the study it is aimed to discuss that critical possibilities created by freedom of expression for fools and jesters on the basis of relation between court jester and political power. Reflections of folly in art from the Middle Ages onwards is examined in the case of contemporary surrealist painter Michael Cheval’s “Absurdity” series. Foucault’s “The Great Internment” and Bakhtins’s theory of “Carnival” are used in the study. It is concluded that Cheval makes social criticism by the practice of detournement and thruogh reproduction revitalizes carnivalesque images in his works.

  16. ANÁLISIS DEL POTENCIAL COMPETITIVO DEL BIOETANOL EN COLOMBIA: UN ENFOQUE DESDE LAS 5 FUERZAS COMPETITIVAS DE MICHAEL PORTER

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    RAMIREZ VELASQUEZ ALEJANDRO

    2012-11-01

    Full Text Available La búsqueda de alternativas de producción y consumo energético requiere una mirada hacia la industria de los combustibles biológicos como el bioetanol que, como alternativa energética, permita superar los inconvenientes generados por los métodos tradicionales de producción y consumo, en especial en los temas políticos, ambientales y sociales y generar ventajas competitivas frente a otras fuentes primarias de energía. En el presente documento,a partir del modelo de las cinco (5 Fuerzas de Michael Porter, se realiza una evaluación de la industria del bioetanol como combustible alternativo y se expone qué tan atractiva o competitiva puede llegar a ser su industria en la actualidad. Para lograr este propósito, se propone una evaluación de las fuerzas competitivas a un panel de expertos, usando escalas deLikert, para encontrar el potencial de la propuesta.

  17. Entrevista com Michael R. KatzDOI: 10.5007/2175-7968.2011v1n27p329

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    Maria Lúcia Barbosa de Vasconcellos

    2011-11-01

    Full Text Available Michael R. Katz graduated from Horace Mann School (New York and attended Williams College (Massachusetts, where he was the very first Russian major. Following graduation in 1966, he studied at Oxford University and the University of Leningrad, where he received his D.Phil. (or Ph.D. in Literature from Oxford. He first taught Russian at Williams and in 1984 became Chair of the Department of Slavic Language and Director of the Title VI Center for Russian and East European Studies at the University of Texas at Austin,. In 1998, he accepted a position as Dean of Language Schools and Schools Abroad at Middlebury College (Vermont. Since his term as Dean ended in 2004, he has been a full-time professor at the Russian Department. Prof. Katz has published several articles on literary translation and written two books. Additionally, he is a published translator of more than a dozen works into English, including novels by Herzen, Chernyshevsky, Dostoevsky, Turgenev, Tolstoy. In this interview, Katz explains how he became a translator, and addresses some important issues concerning the market for translation, his relationship with editors and publishing houses, translation and its critics, and some of the challenges he encountered translating from Russian into English.

  18. In situ forming poly(ethylene glycol)-based hydrogels via thiol-maleimide Michael-type addition.

    Science.gov (United States)

    Fu, Yao; Kao, Weiyuan John

    2011-08-01

    The incorporation of cells and sensitive compounds can be better facilitated without the presence of UV or other energy sources that are common in the formation of biomedical hydrogels such as poly(ethylene glycol) hydrogels. The formation of hydrogels by the step-growth polymerization of maleimide- and thiol-terminated poly(ethylene glycol) macromers via Michael-type addition is described. The effects of macromer concentration, pH, temperature, and the presence of biomolecule gelatin on gel formation were investigated. Reaction kinetics between maleimide and thiol functional groups were found to be rapid. Molecular weight increase over time was characterized via gel permeation chromatography during step-growth polymerization. Swelling and degradation results showed incorporating gelatin enhanced swelling and accelerated degradation. Increasing gelatin content resulted in the decreased storage modulus (G'). The in vitro release kinetics of fluorescein isothiocyanate (FITC)-labeled dextran from the resulting matrices demonstrated the potential in the development of novel in situ gel-forming drug delivery systems. Moreover, the resulting networks were minimally adhesive to primary human monocytes, fibroblasts, and keratinocytes thus providing an ideal platform for further biofunctionalizations to direct specific biological response.

  19. Synthetic and DFT studies towards a unified approach to phlegmarine alkaloids: aza-Michael intramolecular processes leading to 5-oxodecahydroquinolines.

    Science.gov (United States)

    Bradshaw, Ben; Luque-Corredera, Carlos; Saborit, Gisela; Cativiela, Carlos; Dorel, Ruth; Bo, Carles; Bonjoch, Josep

    2013-10-04

    A diastereoselective synthesis of cis-5-oxodecahydroquinolines is described in which three stereocenters are generated in a one-pot reaction. The reaction involves a lithium hydroxide-promoted Robinson annulation/intramolecular aza-Michael domino process from an achiral acyclic tosylamine-tethered β-keto ester. The development and scope of this reaction was facilitated through the use of DFT-based mechanistic studies, which enabled the observed diastereodivergent course of the azacyclization to be rationalized. The varying stereochemistry and stability of the resulting decahydroquinolines was found to depend on whether a β-keto ester or ketone were embedded in the substrates undergoing aminocyclization. This synthetic approach gave access not only to both diastereomeric cis-decahydroquinolines from the same precursor, but also to the corresponding trans isomers, through an epimerization processes of the corresponding N-unsubstituted cis-5-oxodecahydroquinolines. The described methodology provides advanced building-blocks with the three relative stereochemistries required for the total synthesis of phlegmarine alkaloids.

  20. Latter-day Mother Irelands: The Role of Women in Michael Collins and The Wind that Shakes the Barley

    Directory of Open Access Journals (Sweden)

    Pilar Villar-Argáiz

    2007-03-01

    Full Text Available Despite the experimental and subversive work of Irish feminist filmmakers such as Pat Murphy and Margo Harkin in the 1980s, as Gerardine Meaney has contended, “the image of woman as Ireland, Ireland as woman, remains powerful and pervasive in the new Irish cinema” (1998: 250. The cinematic convention of representing Ireland through female characters becomes particularly relevant in two recent Irish historical films: Michael Collins (1996, directed and written by Irish Neil Jordan, and The Wind that Shakes the Barley (2006, written by Scottish Paul Laverty and directed by English Ken Loach. In their dealing with themes such as military occupation, colonisation and the heated debate about the Treaty, both films maintain the nationalist rhetoric that represents Ireland as a woman/mother in a direct manner. Over the course of this essay, I shall try to chart the implications of both films’ representations of women, with a view to demonstrating how, even at present, the trope of Mother Ireland continues to be deep in the national unconscious.

  1. One-pot cascade michael.cyclization reactions of ο-hydroxycinnamaldehydes: Synthesis of functionalized 2,3-dihydrobenzofuranes

    Energy Technology Data Exchange (ETDEWEB)

    Gwon, Sung Hyuk; Kim, Sunggon [Kyonggi Univ., Suwon (Korea, Republic of)

    2012-04-15

    We described the cascade Michael.cyclization reaction of o-hydroxycinnamaldehydes with diethyl α-bromomalonate promoted by potassium carbonate. The reactions provided functionalized 2,3-dihydrobenzofurans in good yields for a variety of o-hydroxyaromatic α,β-unsaturated aldehydes. Current work focuses on expanding the scope of this reaction to other substrates such as sulfur yields, and on developing an efficient catalytic asymmetric variant. 2,3-Dihydrobenzofurans are found in numerous biologically active natural products and synthetic compounds. These are an attractive type of oxygenated compound because their basic core skeleton is present in neolignans, pterocarpans, and synthetic drugs used in the treatment of pulmonary hypertension, atherosclerotic peripheral arterial disease, and central nervous system trauma and ischemia. Owing to the importance of their structures, numerous synthetic methods for 2,3-dihydrobenzofurans have been developed, primarily: radical cyclizations, Lewis acid promoted reactions, anionic cyclizations, and transition-metal catalyzed processes. However, these methods cannot be generalized as much as is desirable, and they yielded poor chemo- and/or stereoselectivities. Hence, the development of an efficient enantioselective synthetic method for obtaining 2,3-dihydrobenzofuran scaffolds attracted our attention.

  2. Jan Rak and Michael J. Tannenbaum present the book "High-pT physics in the heavy ion era"

    CERN Multimedia

    2013-01-01

    Thursday 13 June 2013 from 4 p.m. to 5 p.m. in the Library, Bldg. 52 1-052 The book provides an overview of the basic concepts of large transverse momentum particle physics, with a focus on pQCD phenomena. It examines high-pT probes of relativistic heavy-ion collisions and will serve as a handbook for those working on RHIC and LHC data analyses. Starting with an introduction and review of the field, the authors look at basic observables and experimental techniques, concentrating on relativistic particle kinematics, before moving onto a discussion about the origins of high-pT physics. The main features of high-pT physics are placed within a historical context and the authors adopt an experimental outlook, highlighting the most important discoveries leading up to the foundation of modern QCD theory. High-pT physics in the heavy ion era, by Jan Rak and Michael J. Tannenbaum,  Cambridge University Press, 2013, ISBN  9780521190299. *Coffee will be served from 3 p.m.*

  3. Quality evaluation of commercially sold table water samples in Michael Okpara University of Agriculture, Umudike, Nigeria and surrounding environments

    Directory of Open Access Journals (Sweden)

    D.O. Okorie

    2015-01-01

    Full Text Available In Michael Okpara University of Agriculture, Umudike, Nigeria (MOUAU and surrounding environments, table water of different brands is commercially hawked by vendors. To the best of our knowledge, there is no scientific documentation on the quality of these water samples. Hence this study which evaluated the quality of different brands of water samples commercially sold in MOUAU and surrounding environments. The physicochemical properties (pH, total dissolved solids (TDS, biochemical oxygen demand (BOD, total hardness, dissolved oxygen, Cl, NO3, ammonium nitrogen (NH3N, turbidity, total suspended solids (TSS, Ca, Mg, Na and K of the water samples as indices of their quality were carried out using standard techniques. Results obtained from this study indicated that most of the chemical constituents of these table water samples commercially sold in Umudike environment conformed to the standards given by the Nigerian Industrial Standard (NIS, World Health Organization (WHO and American Public Health Association (APHA, respectively, while values obtained for ammonium nitrogen in these water samples calls for serious checks on methods of their production and delivery to the end users.

  4. A thiourea-functionalized metal-organic macrocycle for the catalysis of Michael additions and prominent size-selective effect.

    Science.gov (United States)

    Yang, Lu; Zhao, Liang; Zhou, Zhen; He, Cheng; Sun, Hui; Duan, Chunying

    2017-03-21

    A discrete tetranuclear thiourea-based metal-organic macrocycle (MOM) with a large size was constructed by a well-designed organic ligand and nickel(ii) ions via self-assembly. Incorporating thiourea groups as hydrogen-bond donors into a metal-organic complex system leads to a new approach for synthesizing functionalized heterogeneous catalysts, as this not only introduces coordination sites serving as chelators, but also overcomes the issues of self-association via intermolecular H-bonding, often occurring in homogeneous systems. The packing structure of this material formed a confined environment suitable for the access of substrate molecules dragged by the strong hydrogen-bond interactions from the thiourea groups, thus achieving a high catalytic performance in Michael additions of nitrostyrenes to nitroalkanes, with remarkable yields and size-selectivity in heterogeneous phase. Moreover, a comparison of the IR spectrum of Ni-SPT with the spectra of dimethyl malonate- and β-nitrostyrene-impregnated Ni-SPT indicated that both substrate molecules, β-nitrostyrene and dimethyl malonate, were able to access the cavity of the trimeric subunit.

  5. A stale challenge to the philosophy of science: commentary on "Is psychology based on a methodological error?" by Michael Schwarz.

    Science.gov (United States)

    Ruck, Nora; Slunecko, Thomas

    2010-06-01

    In his article "Is psychology based on a methodological error?" and based on a quite convincing empirical basis, Michael Schwarz offers a methodological critique of one of mainstream psychology's key test theoretical axioms, i.e., that of the in principle normal distribution of personality variables. It is characteristic of this paper--and at first seems to be a strength of it--that the author positions his critique within a frame of philosophy of science, particularly positioning himself in the tradition of Karl Popper's critical rationalism. When scrutinizing Schwarz's arguments, however, we find Schwarz's critique profound only as an immanent critique of test theoretical axioms. We raise doubts, however, as to Schwarz's alleged 'challenge' to the philosophy of science because the author not at all seems to be in touch with the state of the art of contemporary philosophy of science. Above all, we question the universalist undercurrent that Schwarz's 'bio-psycho-social model' of human judgment boils down to. In contrast to such position, we close our commentary with a plea for a context- and culture sensitive philosophy of science.

  6. Bifunctional Molecular Photoswitches Based on Overcrowded Alkenes for Dynamic Control of Catalytic Activity in Michael Addition Reactions.

    Science.gov (United States)

    Pizzolato, Stefano F; Collins, Beatrice S L; van Leeuwen, Thomas; Feringa, Ben L

    2017-05-02

    The emerging field of artificial photoswitchable catalysis has recently shown striking examples of functional light-responsive systems allowing for dynamic control of activity and selectivity in organocatalysis and metal-catalysed transformations. While our group has already disclosed systems featuring first generation molecular motors as the switchable central core, a design based on second generation molecular motors is lacking. Here, the syntheses of two bifunctionalised molecular switches based on a photoresponsive tetrasubstituted alkene core are reported. They feature a thiourea substituent as hydrogen-donor moiety in the upper half and a basic dimethylamine group in the lower half. This combination of functional groups offers the possibility for application of these molecules in photoswitchable catalytic processes. The light-responsive central cores were synthesized by a Barton-Kellogg coupling of the prefunctionalized upper and lower halves. Derivatization using Buchwald-Hartwig amination and subsequent introduction of the thiourea substituent afforded the target compounds. Control of catalytic activity in the Michael addition reaction between (E)-3-bromo-β-nitrostyrene and 2,4-pentanedione is achieved upon irradiation of stable-(E) and stable-(Z) isomers of the bifunctional catalyst 1. Both isomers display a decrease in catalytic activity upon irradiation to the metastable state, providing systems with the potential to be applied as ON/OFF catalytic photoswitches. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Evolution of generic competitive strategies and the importance of Michael E. Porter La evolución de las estrategias genéricas de competición y la influencia de Michael E. Porter A evolução das estratégias genéricas de competição e a influência de Michael E. Porter

    OpenAIRE

    Wilson Weber; Edison Fernandes Polo

    2010-01-01

    Generic competitive strategies are considered almost as archetypes in Business Administration, sometimes leading to over simplification of their concepts as well as underestimation of their importance. Since publication in 1980, as part of Michael E. Porter's book Competitive Strategy, the generic strategies of Differentiation, Leadership in Total Cost and Focus have been used in whole or in part, in various approaches, accelerating dissemination of Porter's work and the subject itself. As a ...

  8. Michael Jäckel, Julia Derra, Cornelia Eck: SchönheitsAnsichten. Geschlechterbilder in Werbeanzeigen und ihre Bewertung. Baden-Baden: Nomos Verlag 2009.

    Directory of Open Access Journals (Sweden)

    Waltraud Posch

    2010-11-01

    Full Text Available Michael Jäckel, Julia Derra, and Cornelia Eck’s cross-generational study answers the question as to which concepts of beauty are presented in magazine advertisements and how recipients react to these concepts. The book provides an important basis for Media Studies and Gender Sociology particularly because it also shows medial constructions of gender that are initially invisible and because it shows gender related illustrations of physicality and beauty.In einer generationenübergreifenden Studie gehen Michael Jäckel, Julia Derra und Cornelia Eck der Frage nach, welche Schönheitsbilder in der Zeitschriftenwerbung präsentiert und wie diese von Rezipient/-innen aufgenommen werden. Das Buch liefert eine wichtige Basis für Medienforschung und Soziologie der Geschlechter, zumal es auch vordergründig nicht sichtbare mediale Konstruktionen von Geschlecht und die geschlechtsbezogene Darstellung von Körperlichkeit und Schönheit aufzeigt.

  9. Diversity-Oriented Synthesis Based on the DPPP-Catalyzed Mixed Double-Michael Reactions of Electron-Deficient Acetylenes and β-Amino Alcohols

    Directory of Open Access Journals (Sweden)

    Yi Chiao Fan

    2011-05-01

    Full Text Available In this study, we prepared oxizolidines through 1,3-bis(diphenylphosphino-propane (DPPP–catalyzed mixed double-Michael reactions of b-amino alcohols with electron-deficient acetylenes. These reactions are very suitable for the diversity-oriented parallel syntheses of oxizolidines because: (i they are performed under mild metal-free conditions and (ii the products are isolated without complicated work-up. To demonstrate the applicability of mixed double-Michael reactions for the preparation of five-membered-ring heterocycles, we prepared 60 distinct oxazolidines from five β-amino alcohols and 12 electron-deficient acetylenes. We synthesized 36 of these 60 oxazolidines in enantiomerically pure form from proteinogenic amino acid–derived β-amino alcohols.

  10. Theoretical elucidation on the functional role of pyrrolidine-type ionic liquids in inducing stereoselectivity of the Michael addition of cyclohexanone with trans-β-nitrostyrene.

    Science.gov (United States)

    Sun, Hui; Zhang, Dongju

    2011-03-01

    Density functional theory calculations have been carried out to elucidate the stereoselectivity of the Michael addition of cyclohexanone with trans-β-nitrostyrene, induced by a chiral ionic liquid (CIL) pyrrolidine-imidazolium bromide. By comparison of the C-C bond forming processes in the absence and presence of Br(-) anion, we found that intermolecular H-bonds between the imidazolium cation and the nitro group of trans-β-nitrostyrene and the steric hindrance of the imidazolium cation moiety on the Si-face of enamine dominate the stereoselectivity of the Michael addition. The presence of Br(-) anion obviously reduces the barrier by increasing the polarity of the C4=C5 bond of enamine. The theoretical results rationalize well the early experimental finding, and reveal a valuable clue for the further CIL design with high catalytic efficiency.

  11. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies.

    Science.gov (United States)

    Dragovich, P S; Webber, S E; Babine, R E; Fuhrman, S A; Patick, A K; Matthews, D A; Lee, C A; Reich, S H; Prins, T J; Marakovits, J T; Littlefield, E S; Zhou, R; Tikhe, J; Ford, C E; Wallace, M B; Meador, J W; Ferre, R A; Brown, E L; Binford, S L; Harr, J E; DeLisle, D M; Worland, S T

    1998-07-16

    The structure-based design, chemical synthesis, and biological evaluation of peptide-derived human rhinovirus (HRV) 3C protease (3CP) inhibitors are described. These compounds incorporate various Michael acceptor moieties and are shown to irreversibly bind to HRV serotype 14 3CP with inhibition activities (kobs/[I]) ranging from 100 to 600 000 M-1 s-1. These inhibitors are also shown to exhibit antiviral activity when tested against HRV-14-infected H1-HeLa cells with EC50's approaching 0.50 microM. Extensive structure-activity relationships developed by Michael acceptor alteration are reported along with the evaluation of several compounds against HRV serotypes other than 14. A 2.0 A crystal structure of a peptide-derived inhibitor complexed with HRV-2 3CP is also detailed.

  12. MICHAEL LAU×NIKE 2008 BEIJING BMX NIKE BLAZER PREMIUM SB 公仔王的小轮车情节

    Institute of Scientific and Technical Information of China (English)

    Brian

    2008-01-01

    在奥运装备发布会上,很多人都被眼前这套Michael Lau × Nike 2008 Beijing BMX Nike Blazer Premium SB吸引了,奥运的周边产品当然面对的还是消费群体。其实本次整个套装从里到外都倾注了Michael Lau很大的心血。首先搪胶鞋盒倒模出栩栩如生的泥土效果,再加上被小轮车辗过的坑纹效果,绝对引爆眼球。公仔则以BMX车手造型作为设定,分别以红、黑、金三个颜色配合,

  13. Green and efficient synthesis of novel bispyrazoles through a tandem Knoevenagel and Michael type reaction using nanowire zinc oxide as a powerful and recyclable catalyst

    OpenAIRE

    ESKANDARI, Khalil; KARAMI, Bahador; Khodabakhshi, Saeed; HOSEINI, SEYYED JAFAR

    2015-01-01

    Zinc oxide nanowires (ZnO NWs) were prepared and characterized by scanning electron microscopy, powder X-ray diffraction, and transmission electron microscopy analyses. ZnO NWs were then employed as heterogeneous and recyclable catalyst for green synthesis of some new and known bispyrazole derivatives through a tandem Knoevenagel and Michael type addition reaction of aromatic aldehyde and pyrazolone. The synthetic method is operationally simple and affords product with high yields in short re...

  14. Enantioselective organocatalyzed Oxa-Michael-Aldol cascade reactions: Construction of chiral 4H-chromenes with a trifluoromethylated tetrasubstituted carbon stereocenter

    KAUST Repository

    Zhang, Jing

    2015-03-13

    The first organocatalytic asymmetric synthesis of 4H-chromenes bearing a trifluoromethylated tetrasubstituted carbon center is presented. Chiral secondary amines promote the oxa-Michael-aldol cascade reaction between alkynals and 2-trifluoroacetylphenols via iminium-allenamine activation to produce pharmaceutically important heterocycles with excellent enantioselectivities. The proposed reaction can be scaled-up easily with maintenance of the excellent enantioselectivity. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Evaluation Strategy Michael Porter's five forces model of the competitive environment on the dairy industry (Case Study: Amoll Haraz Dvshh dairy company)

    OpenAIRE

    Mohammad Bolorian Tehrani; Faezeh Rahmani

    2016-01-01

    State of competition in an industry depends on five basic forces. Porter's five forces model including bargaining power of customers, bargaining power of suppliers, threat of newcomers to the industry, threat of substitute products is the intensity of rivalry between competitors. Joint strength of these forces determines the ultimate benefit of potentially any industry. The purpose of this study was to evaluate the competitive environment of the dairy industry based on Michael Por...

  16. A facile synthesis of 1,2,3-triazolyl indole hybrids via SbCl3-catalysed Michael addition of indoles to 1,2,3-triazolyl chalcones

    Indian Academy of Sciences (India)

    Poovan Shanmugavelan; Murugan Sathishkumar; Sangaraiah Nagarajan; Alagusundaram Ponnuswamy

    2012-07-01

    An efficient, facile and environmentally benign synthesis of a library of 1,2,3-triazolyl chalcone hybrids (3a-u) has been accomplished by grinding the reactants at room temperature in excellent yields in very short reaction time. Subsequently, SbCl3 catalysed Michael addition of indoles to the chalcones afford 1,2,3-triazolyl indole hybrids (5a-l) in excellent yields.

  17. Asymmetric Michael addition/intramolecular cyclization catalyzed by bifunctional tertiary amine-squaramides: construction of chiral 2-amino-4H-chromene-3-carbonitrile derivatives.

    Science.gov (United States)

    Gao, Yu; Du, Da-Ming

    2014-10-01

    The efficient asymmetric Michael addition/intramolecular cyclization of malononitrile with dienones catalyzed by a chiral bifunctional tertiary amine-squaramide catalyst for the synthesis of chiral 2-amino-4H-chromene-3-carbonitrile derivatives was developed. The corresponding products were obtained in good to excellent yields (up to 99%) with excellent enantioselectivities (up to 98% ee) for most of the bisarylidenecyclopentanones. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Stereoselective amine-thiourea-catalysed sulfa-Michael/nitroaldol cascade approach to 3,4,5-substituted tetrahydrothiophenes bearing a quaternary stereocenter

    Directory of Open Access Journals (Sweden)

    Sara Meninno

    2016-04-01

    Full Text Available An investigation on the stereoselective cascade sulfa-Michael/aldol reaction of nitroalkenes and commercially available 1,4-dithiane-2,5-diol to 3,4,5-substituted tetrahydrothiophenes, bearing a quaternary stereocenter, is presented. A secondary amine thiourea derived from (R,R-1,2-diphenylethylamine was found to be the most effective catalyst when using trans-β-methyl-β-nitrostyrenes affording the heterocyclic products in good yields and moderate stereoselectivities.

  19. The first peripherally masked thiol dendrimers: a facile and highly efficient functionalization strategy of polyester dendrimers via one-pot xanthate deprotection/thiol-acrylate Michael addition reactions.

    Science.gov (United States)

    Auty, Sam E R; Andrén, Oliver; Malkoch, Michael; Rannard, Steven P

    2014-06-25

    Introducing multiple reactive functional groups at the periphery of dendrimer materials presents considerable challenges if the functionality is able to self-react. An efficient and facile approach to introducing masked thiols at the surface of polyester dendrimers is presented. One-pot, deprotection/thiol-acrylate Michael addition from the xanthate-functional dendritic substrates (generation zero to two) has been achieved for the first time, with high efficiency demonstrated using three acrylates of varying chemistry and avoiding disulfide formation.

  20. N-Heterocyclic Carbene Catalyzed [4+2] Annulation of Enals via a Double Vinylogous Michael Addition: Asymmetric Synthesis of 3,5-Diaryl Cyclohexenones.

    Science.gov (United States)

    Chen, Xiang-Yu; Liu, Qiang; Chauhan, Pankaj; Li, Sun; Peuronen, Anssi; Rissanen, Kari; Jafari, Ehsan; Enders, Dieter

    2017-05-22

    A strategy for the N-heterocyclic carbene (NHC) catalyzed asymmetric synthesis of 3,5-diaryl substituted cyclohexenones has been developed via oxidative [4+2] annulation of enals and alkenylisoxazoles. It is the first example of using NHC organocatalysis in a double vinylogous Michael type reaction, a challenging but highly desirable topic. This unprecedented protocol affords good yields as well as high to excellent diastereo- and enantioselectivities. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Solvent-free Thia-Michael Addition Reactions Using 3-[Bis(alkylthio)methylene]pentane-2,4-diones as Efficient and Odorless Thiol Equivalents

    Institute of Scientific and Technical Information of China (English)

    LIN Chun; ZHAO Xiao-Liang; OUYANG Yan; YU Hai-Feng; DONG De-Wen

    2008-01-01

    3-[Bis(alkylthio)methylene]pentane-2,4-diones (1a and 1b) have been investigated as nonthiolic and odorless thiol equivalents for thia-Michael addition reactions under solvent-free conditions. Promoted by HCl (aq.), the cleavage of compounds 1 took place, and the in-situ generated thiols underwent facile conjugate addition to α,β-unsaturated carbonyl compounds 2 affording the corresponding β-keto sulfides 3 in high yields.

  2. Efficacy and safety of Dr Michaels® (Soratinex®) product family for the topical treatment of psoriasis: a monitored status study.

    Science.gov (United States)

    França, K; Novotny, F; Hercogovấ, J; Fioranelli, M; Gianfaldoni, S; Chokoeva, A A; Tchernev, G; Wollina, U; Tirant, M; Roccia, M G; Lotti, T

    2016-01-01

    The aim of the study was to investigate the efficacy and safety of Michaels® (Soratinex®) remedies in patients suffering from chronic plaque psoriasis in a Czech population. Seventy-five (34 female/41 male) patients, aged 18-72 years old (mean age: 38.5 years) with mild to severe plaque psoriasis participated in the study. The products, including cleansing gel, ointment and skin conditioner, containing fruit acid complex, herbal oils and emulsifiers, were used twice daily and in the same manner for all the skin lesions. The study period was eight weeks. Histologic variables and various blood picture parameters, including FW, glucose, cholesterol, triacylglyceroles, bilirubin, GMT, ALT, AST, creatinine, uric acid and urea in blood were monitored, before and after therapy with Michaels® (Soratinex®) treatment. Assessment, using the Psoriasis Activity Severity Index (PASI) scores and photographic analysis, was done at time 0, and after 2, 4, 6 and 8 weeks. Patient’s improvement was determined by the percentage reduction of the PASI scores. Side effects and tolerability were also evaluated. After 8 weeks using Dr Michaels® (Soratinex®) treatment course, 5 patients had a moderate improvement, with the resolution of 25-50% of skin lesions; 11 patients showed a good improvement, with the resolution of 51-75% of lesions. Another 50 patients had an outstanding improvement, with the regression of 76-100% of lesions. Only 4 patients did not achieve an improvement of psoriasis. Six patients experienced folliculitis, which resolved without cessation of treatment. Three patients worsened and discontinued treatment. Six patients dropped out because of non-compliance. The blood results and histologic findings were all normal. Our investigation shows that Dr Michaels® (Soratinex®) products can be safely and successfully used in the treatment of chronic plaque psoriasis.

  3. A Stereoselective Route to Tetrahydrobenzoxazepines and Tetrahydrobenzodiazepines via Ring-Opening and Aza-Michael Addition of Activated Aziridines with 2-Hydroxyphenyl and 2-Aminophenyl Acrylates.

    Science.gov (United States)

    Shahi, Chandan Kumar; Bhattacharyya, Aditya; Nanaji, Yerramsetti; Ghorai, Manas K

    2017-01-06

    A simple and efficient synthetic route to 2,3,4,5-tetrahydrobenzoxazepines and -benzodiazepines bearing easily functionalizable appendages has been developed by ring-opening of activated aziridines with 2-hydroxyphenyl acrylates and 2-aminophenyl acrylate, respectively, and subsequent intramolecular C-N bond formation through palladium-catalyzed aza-Michael reaction. The straightforward synthetic approach delivers the desired molecular scaffolds in high yields (up to 82%) with excellent stereoselectivity (ee up to 94%).

  4. Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases).

    Science.gov (United States)

    Ovat, Asli; Muindi, Fanuel; Fagan, Crystal; Brouner, Michelle; Hansell, Elizabeth; Dvorák, Jan; Sojka, Daniel; Kopácek, Petr; McKerrow, James H; Caffrey, Conor R; Powers, James C

    2009-11-26

    Aza-peptide Michael acceptors and epoxides with the general structure of YCO-Ala-Ala-AAsn-trans-CH horizontal lineCHCOR and YCO-Ala-Ala-AAsn-EP-COR, respectively, are shown to be potent inhibitors of asparaginyl endopeptidases (legumains) from the bloodfluke, Schistosoma mansoni (SmAE), and the hard tick, Ixodes ricinus (IrAE). Structure-activity relationships (SARs) were determined for a set of 41 aza-peptide Michael acceptors and eight aza-peptide epoxides. Both enzymes prefer disubstituted amides to monosubstituted amides in the P1' position, and potency increased as we increased the hydrophobicity of the inhibitor in this position. Extending the inhibitor to P5 resulted in increased potency, especially against IrAE, and both enzymes prefer small over large hydrophobic residues at P2. Aza-peptide Michael acceptor inhibitors are more potent than aza-peptide epoxide inhibitors, and for some of these compounds, second-order inhibiton rate constants are the fastest yet discovered. Given the central functions of these enzymes in both parasites, the data presented here may facilitate the eventual design of selective antiparasitic drugs.

  5. A new approach to evaluating the extent of Michael adduct formation to PAH quinones: tetramethylammonium hydroxide (TMAH) thermochemolysis with GC/MS.

    Science.gov (United States)

    Briggs, Mary K; Desavis, Emmanuel; Mazzer, Paula A; Sunoj, R B; Hatcher, Susan A; Hadad, Christopher M; Hatcher, Patrick G

    2003-11-01

    Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants that are converted to cytotoxic and carcinogenic metabolites, quinones, by detoxifying enzyme systems in animals. PAH metabolites such as the quinones can form Michael adducts with biological macromolecules containing reactive nucleophiles, making detection of exposure to PAHs difficult using conventional techniques. A technique has been developed for detecting exposure to PAHs. Tetramethylammonium hydroxide (TMAH) thermochemolysis coupled with GC/MS is proposed as an assay method for PAH quinones that have formed Michael adducts with biological molecules. Three PAH quinones (1,4-naphthoquinone, 1,2-naphthoquinone, and 1,4-anthraquinone) and 1,4-benzoquinone were reacted with cysteine, and the TMAH thermochemolysis method was used to assay for both thiol and amine adduction between the quinones and the cysteine. Additional studies with 1,4-naphthoquinone adducts to glutathione and bovine serum albumin showed the same thiol and amine TMAH thermochemolysis products with larger peptides as was observed with cysteine adducts. The TMAH GC/MS method clearly shows great promise for detecting PAH quinones, produced by enzymatic conversion of PAHs in biological systems, that have been converted to respective Michael adducts.

  6. Jane Eyre de Michael Berkeley et de David Malouf : La transposition opératique d’un grand classique de la littérature anglaise Jane Eyre by Michael Berkeley and David Malouf: The Operatic Rewriting of a Great Classic English Novel

    Directory of Open Access Journals (Sweden)

    Jean-Philippe Héberlé

    2009-10-01

    Full Text Available This article discusses Michael Berkeley’s opera Jane Eyre. Premiered on June 30, 2000 by Music Theatre Wales at the Cheltenham International Festival of Music, this opera is based on the novel by Charlotte Brontë and the libretto is written by the Australian poet, novelist, playwright and librettist, David Malouf. It was risky and daring to try to adapt this famous and long novel for the stage. We will particularly focus on the similarities and differences between the novel and the opera as well as on the strategies used both by David Malouf and Michael Berkeley to adapt it. Through the analysis of the similarities we will see how Michael Berkeley set to music some of the great themes and elements of the novel: passion, a sense of entrapment, the “Gothic” atmosphere. On the other hand, the analysis of the discrepancies between the novel and the opera as they appear in both the libretto and the music will lead us to a modern apprehension of the characterization of madness as well as of the metafictional dimension of the rewriting of Jane Eyre by David Malouf and Michael Berkeley.  

  7. A small stone column of the altar screen from the treasures of St Archangel Michael's monastery in Prevlaka

    Directory of Open Access Journals (Sweden)

    Crnčević Dejan

    2013-01-01

    Full Text Available Amongst exhibited fragments of carved stone decorations in the monastery of St Archangel Michael in Prevlaka, Boka Kotorska, situated on the ground floor of the monastery's accommodation quarters, there is a segment of stone liturgical furnishings which is, among other things, distinguished by its monumental dimensions, the high level of its craftsmanship, and the important artistic value of its carved decorations. This small stone column was found by chance as a surface-level find on the neighbouring island of St Gavrilo. This stone column is made from a monolithic piece of high- quality, light-grey marble. It is 96 cm in height, 20 cm wide at the front, 18.5 cm wide at the side, and 13cm wide at the rear. These dimensions indicate that the fragment has the form of an elongated hexahedron, with sides of unequal width. Only the front of this stone fragment is marked with relief decorations, comprising a regularly shaped two-part curled sprouting vine. Moving with its undulating rhythm, its arc defines a space in which is located the central motif of the decoration. This comprises the motif of a bud in the form of stylised crinoline flower, composed of two lateral leaves with a pronounced bulge in the middle. These tightly bent lateral leaves with sharp ends, together with the root of the formed shoot, leave an empty space filled with an offshoot in the form of a regularly formed volute. The left lateral side of the stone column is marked by a long but relatively shallow channel, created around its axis, with a width of 7.5 cm. Its rear side is divided by its own height into two vertical fields, of almost the same width - 6 and 7 cm respectively - one slightly elevated compared to the other. The right lateral side of the column is slanted and only lightly sculptured. On the upper surface of the pillar, a relatively shallow circular hole with a small span is visible, intended as a connection point for other segments that would have been placed on

  8. Physalins with anti-inflammatory activity are present in Physalis alkekengi var. franchetii and can function as Michael reaction acceptors.

    Science.gov (United States)

    Ji, Long; Yuan, Yonglei; Luo, Liping; Chen, Zhe; Ma, Xiaoqiong; Ma, Zhongjun; Cheng, Lin

    2012-04-01

    Michael reaction acceptors (MRAs) are a class of active molecules that are directly or indirectly involved in various cellular processes, including the regulation of many signaling pathways. In this study, the inducible nitric oxide synthase (iNOS) assay was used to demonstrate that the dichloromethane extract of Physalis alkekengi var. franchetii (DCEP) possesses anti-inflammatory activity that might be attributed to the modification of key cysteine residues in IKKβ by the MRAs in DCEP. To isolate these MRAs, glutathione (GSH) was employed, and a simple ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) screening method was developed to investigate the GSH conjugates with potential MRAs. Five physalins, including one new compound isophysalin A (2), together with four known steroidal compounds, physalin A (1), physalin O (3), physalin L (4) and physalin G (5), were isolated to evaluate the GSH conjugating abilities, and it was indicated that compounds 1, 2 and 3, which had a common α,β-unsaturated ketone moiety, exhibited conjugating abilities with GSH and also showed significant nitric oxide (NO) production inhibiting activities. The anti-inflammatory activities of compounds 1, 2 and 3 might be attributed to their targeting multiple cysteine residues on IKKβ; therefore, the alkylation of IKKβ by compound 1 was further studied by micrOTOF-MS. The result showed that six cysteine residues (C(59), C(179), C(299), C(370), C(412), and C(618)) were alkylated, which indicated that IKKβ is a potential target for the anti-inflammatory activity of physalin A.

  9. Delayed entry into first marriage and marital stability: Further evidence on the Becker-Landes-Michael hypothesis

    Directory of Open Access Journals (Sweden)

    Evelyn Lehrer

    2013-09-01

    Full Text Available BACKGROUND In their pioneering research, Becker, Landes, and Michael (1977 found that beyond age 30 there is a positive relationship between women's age at first marriage and marital instability. They interpreted this finding as a "poor-match effect" emerging when the biological clock begins to tick. OBJECTIVE Our objective was to ascertain with more recent data whether or not there is evidence of a poor match effect and if so, whether it is associated with higher marital instability. METHODS We used data on non-Hispanic white women from the 2006-2010 National Surveys of Family Growth (NSFG (N = 3,184. RESULTS We found evidence of the existence of a poor-match effect: women who delay marriage disproportionately make unconventional matches, which are generally associated with high marital instability. We also found, however, that their unions are very solid. Both of these results were consistent with earlier findings for the 1995 and 2002-2003 NSFG cycles. In attempting to explain this puzzle, we proposed and tested competing hypotheses. We found that the destabilizing effects associated with indicators of unconventional matches are also present in marriages contracted late, but are dwarfed by the stabilizing influences associated with higher levels of education and older ages. CONCLUSIONS This paper contributes to our understanding of the determinants of marital instability and the poor match effect by providing a new interpretation for the puzzle described above. COMMENTS Our findings have implications for analyses of changes over time in the extent of positive assortative mating in the marriage market, and for the extensive literature showing that heterogamy in traits that are complementary in the context of marriage is destabilizing -- heterogamous marriages contracted at a late age are likely to be stable.

  10. Tim Burton lavastab Batmani muusikali. Placido Domingo palkas "Star Warsi" võluri. MTV muusikaauhindade show'l narriti Michael Jacksonit. Hendrixi põlenud kitarr läheb müüki

    Index Scriptorium Estoniae

    2002-01-01

    Jim Steinman kirjutab muusikat Tim Burtoni 2005. aastal lavale tulevale Batmani muusikalile. Los Angelese ooperimaja juht Domingo palkas George Lucase Wagneri ooperi "Nibelungide sõrmus" eriefektide ettevalmistamiseks. Britney Spears nimetas Michael Jacksonit Millenniumi artistiks.

  11. Tim Burton lavastab Batmani muusikali. Placido Domingo palkas "Star Warsi" võluri. MTV muusikaauhindade show'l narriti Michael Jacksonit. Hendrixi põlenud kitarr läheb müüki

    Index Scriptorium Estoniae

    2002-01-01

    Jim Steinman kirjutab muusikat Tim Burtoni 2005. aastal lavale tulevale Batmani muusikalile. Los Angelese ooperimaja juht Domingo palkas George Lucase Wagneri ooperi "Nibelungide sõrmus" eriefektide ettevalmistamiseks. Britney Spears nimetas Michael Jacksonit Millenniumi artistiks.

  12. Michael's Inside Scoop: Genetics

    Science.gov (United States)

    ... Pertussis Influenza Hepatitis B Measles Rubella Diphtheria Meningitis Chicken Pox Epilepsy Stalking SARS Who What When Where ... Walking White-Water Rafting Yoga I Heard Hurdle Race Meeting the Challenge Asthma U Can Do It ...

  13. Flying Fish Michael Phelps

    Institute of Scientific and Technical Information of China (English)

    何非凡

    2009-01-01

    2008年的北京奥运会将铭记美国游泳选手迈克尔·菲尔普斯的名字——一个人在一届赛事上得到八枚金牌,其中七次打破世界纪录,一次打破奥运会纪录。美国神童给世界留下了一个难以追赶的水花。

  14. The returned / Michael Tarm

    Index Scriptorium Estoniae

    Tarm, Michael

    1999-01-01

    Sakslaste pool võidelnud ja end ameeriklastele vangi andnud eestlased Harald Rajamets ja Leopold Padjus anti Nõukogude riigile välja ilma igasuguste selgituste või hoiatusteta. Erinevalt rootslastest pole ameeriklased isegi mitte vabandanud

  15. Reis tulevikku / Michael Reid

    Index Scriptorium Estoniae

    Reid, Michael

    2006-01-01

    Viimase 13 kuu jooksul toimusid Ladina-Ameerikas 12 presidendivalimised, 2007. aastal kulub poliitikas põhitähelepanu tõelistele väljakutsetele ning ametisse valitud riigijuhid seisavad silmitsi maailmamajanduse ja jätkamist vajavate majandusreformidega. Diagramm: Ladina-Ameerika SKP. Vt. samas: Tango kahele

  16. Tiheduse kurvid / Michael Sorkin

    Index Scriptorium Estoniae

    Sorkin, Michael

    2007-01-01

    Autor toob välja linnade kasvu mõju maa ökoloogiale. Tema sõnul on demokraatliku linna jaoks kriitiline tihedus linlike vormide ning käitumisviiside tihke kogum ning just tiheduses on vastus jätkusuutlikuks edasi elamiseks meie planeedil

  17. Reis tulevikku / Michael Reid

    Index Scriptorium Estoniae

    Reid, Michael

    2006-01-01

    Viimase 13 kuu jooksul toimusid Ladina-Ameerikas 12 presidendivalimised, 2007. aastal kulub poliitikas põhitähelepanu tõelistele väljakutsetele ning ametisse valitud riigijuhid seisavad silmitsi maailmamajanduse ja jätkamist vajavate majandusreformidega. Diagramm: Ladina-Ameerika SKP. Vt. samas: Tango kahele

  18. Michael York, Pagan Theology

    Directory of Open Access Journals (Sweden)

    Terry GIFFORD

    2004-10-01

    Full Text Available For Christian missionaries the word ‘pagan’ was a pejorative that implied ‘primitive’, either in the sense of devil worship or barren atheism. From this tradition the word has been associated with either the worship of the wrong gods immanent in the natural environment, or of a godless superstition relating to the spirits alive in nature. Of course, Christianity has been adept at incorporating a diversity of pagan beliefs, occasions and rituals into its colonising practice throughout the worl...

  19. Tiheduse kurvid / Michael Sorkin

    Index Scriptorium Estoniae

    Sorkin, Michael

    2007-01-01

    Autor toob välja linnade kasvu mõju maa ökoloogiale. Tema sõnul on demokraatliku linna jaoks kriitiline tihedus linlike vormide ning käitumisviiside tihke kogum ning just tiheduses on vastus jätkusuutlikuks edasi elamiseks meie planeedil

  20. On Michael Addition Reactions of Chalcones%查尔酮类化合物的 Michael加成反应

    Institute of Scientific and Technical Information of China (English)

    张鹏会; 李艳春; 蒲雯

    2016-01-01

    A series of chalcones are synthesized from aromatic aldehyde and acetophenone ,with H2 O as the solvent and sodium hydroxide as the catalyst .A series of Michael addition products are obtained from these chalcones and ethyl acetoacetate , catalyzed by sodium hydroxide and anhydrous sodium carbonate under the assistance of ultrasonic irradiation .And the inflences of the addition reaction condition on the yield are studied .The premium condition are determined by followings:the molar ratio of chalcone and ethyl acetoacetate is 1/1.5,sodium hydroxide/anhydrous sodium carbonate is 1/1.5 under PEG -400/H2O in 40oC,the desired product is obtained,and the yield can be up to 91.2%.The method of this syn-thesis has advantages such as simple to operate ,short reaction time and high yield .%以芳香醛与苯乙酮为原料, NaOH 为催化剂,在水相中合成了一系列查尔酮化合物。在超声辅助下,研究了混合碱( NaOH-Na2 CO3)催化查尔酮与三乙(乙酰乙酸乙酯)的 Michael加成反应,合成了一系列Michael加成产物,并对影响反应的因素进行了探究,得出最佳反应条件为:40oC 下,在 PEG -400/H2O 介质中,n查尔酮/n三乙=1/1.5,nNaOH/nNa2CO3=1/1.5,得到目标产物的产率最好,高达91.2%。此方法操作简单,反应时间短,产率高。