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Sample records for sas 300c terrameter

  1. SAS essentials mastering SAS for data analytics

    CERN Document Server

    Elliott, Alan C

    2015-01-01

    A step-by-step introduction to using SAS® statistical software as a foundational approach to data analysis and interpretation Presenting a straightforward introduction from the ground up, SAS® Essentials: Mastering SAS for Data Analytics, Second Edition illustrates SAS using hands-on learning techniques and numerous real-world examples. Keeping different experience levels in mind, the highly-qualified author team has developed the book over 20 years of teaching introductory SAS courses. Divided into two sections, the first part of the book provides an introduction to data manipulation, st

  2. SAS for dummies

    CERN Document Server

    McDaniel, Stephen

    2010-01-01

    The fun and easy way to learn to use this leading business intelligence tool Written by an author team who is directly involved with SAS, this easy-to-follow guide is fully updated for the latest release of SAS and covers just what you need to put this popular software to work in your business. SAS allows any business or enterprise to improve data delivery, analysis, reporting, movement across a company, data mining, forecasting, statistical analysis, and more. SAS For Dummies, 2nd Edition  gives you the necessary background on what SAS can do for you and explains how to use the Enterprise Gui

  3. Nyheder i SAS

    DEFF Research Database (Denmark)

    Milhøj, Anders

    2016-01-01

    I sommeren 2015 blev Analytical Produts opgraderet version 14.1, men stadig til Base SAS, version 9.4 sendt på markedet. Denne opdatering til nu Analytical Products 14.1 indeholder opdateringer af de analytiske programpakker indenfor statistik, økonometri, operationsanalyse etc. Disse opdateringer...... er nu løsrevet fra samtidige opdateringer af det samlede SAS-program. Desuden er den gratis SAS-applikation SAS-U opdateret; især er det bemærkelsesværdigt at der via SAS-U nu også stilles procedurer til rådighed for avancerede ikke-modelbaserede tidsrækkeanalyser....

  4. Matrixregning med SAS

    DEFF Research Database (Denmark)

    Andersen, Aage T.; Feilberg, Michael; Milhøj, Anders

    IML i SAS anvendes til matrixberegninger som en integreret del af SAS pakken. Den anvendes typisk til matrixberegninger i tilknytning til andre SAS applikationer, fx kan matricer let dannes ud fra datasæt i SAS. Desuden indeholder IML en række videregående matematiske og statistiske subroutiner......, der ikke findes andre steder i SAS.I bogen gennemgås matrixregning svarende til et indledende matematikkursus ved en højere læreanstalt. Den teoretiske gennemgang understøttes og demonstreres konsekvent med IML programmering, så fokus er på praktiske anvendelser af matricer....

  5. SAS and Sata SSDs

    Science.gov (United States)

    Yasarapu, S.

    This chapter focuses on the different types of solid state drives. The chapter details the differences between consumer and enterprise solid state drives and also details the differences between SAS and SATA solid state drive and what lies ahead for SATA and SAS protocols for SSDs.

  6. Data analysis using SAS

    CERN Document Server

    Peng, Chao-Ying Joanne

    2008-01-01

    "Peng provides an excellent overview of data analysis using the powerful statistical software package SAS. This book is quite appropriate as a self-placed tutorial for researchers, as well as a textbook or supplemental workbook for data analysis courses such as statistics or research methods. Peng provides detailed coverage of SAS capabilities using step-by-step procedures and includes numerous comprehensive graphics and figures, as well as SAS printouts. Readers do not need a background in computer science or programming. Includes numerous examples in education, health sciences, and business.

  7. SAS for dummies

    CERN Document Server

    McDaniel, Stephen

    2010-01-01

    The fun and easy way to learn to use this leading business intelligence tool Written by an author team who is directly involved with SAS, this easy-to-follow guide is fully updated for the latest release of SAS and covers just what you need to put this popular software to work in your business. SAS allows any business or enterprise to improve data delivery, analysis, reporting, movement across a company, data mining, forecasting, statistical analysis, and more. SAS For Dummies, 2nd Edition  gives you the necessary background on what SAS can do for you and explains how to use the Enterprise Guide. SAS provides statistical and data analysis tools to help you deal with all kinds of data: operational, financial, performance, and more Places special emphasis on Enterprise Guide and other analytical tools, covering all commonly used features Covers all commonly used features and shows you the practical applications you can put to work in your business Explores how to get various types of data into the software and...

  8. Sidste nyt fra SAS

    DEFF Research Database (Denmark)

    Milhøj, Anders

    2014-01-01

    I juli 2013 blev version 9.4 af SAS sendt på markedet. Denne release indeholdt ikke mange nye faciliteter indenfor statistik, økonometri, operationsanalyse etc, men alligevel er der vigtige aspekter at forholde sig til. Ved årsskiftet 2013/2014 er der siden kommet en opdatering af de analytiske...... programpakker for statistik, økonometri, operationsanalyse etc uden en samtidig opdatering af det samlede SAS-program. Denne opdatering kaldes Analytical Products 13.1 og er en væsentlig opdatering fra version 12, der i første version kom i august 2012....

  9. Nyheder i SAS

    DEFF Research Database (Denmark)

    Milhøj, Anders

    2015-01-01

    I juli 2013 blev version 9.4 af SAS sendt på markedet. Denne release indeholdt ikke i sig selv mange nye faciliteter indenfor statistik, økonometri, operations-analyse etc, men alligevel er der vigtige aspekter at forholde sig til. Ved årsskiftet 2013/2014 kom opdateringen Analytical Products 13.......1 af de analytiske programpakker for statistik, økonometri, operationsanalyse etc uden en samtidig opdatering af det samlede SAS-program. Denne opdatering er siden fulgt op med en yderligere opdatering 13.2 i august 2014....

  10. SASWeave: Literate Programming Using SAS

    Directory of Open Access Journals (Sweden)

    Russell V. Lenth

    2007-05-01

    Full Text Available SASweave is a collection of scripts that allow one to embed SAS code into a LATEX document, and automatically incorporate the results as well. SASweave is patterned after Sweave, which does the same thing for code written in R. In fact, a document may contain both SAS and R code. Besides the convenience of being able to easily incorporate SAS examples in a document, SASweave facilitates the concept of “literate programming”: having code, documentation, and results packaged together. Among other things, this helps to ensure that the SAS output in the document is in concordance with the code.

  11. SASWeave: Literate Programming Using SAS

    DEFF Research Database (Denmark)

    Lenth, Russell V; Højsgaard, Søren

    2007-01-01

    the convenience of being able to easily incorporate SAS examples in a document, SASweave facilitates the concept of "literate programming": having code, documentation, and results packaged together. Among other things, this helps to ensure that the SAS output in the document is in concordance with the code...

  12. SASWeave: Literate Programming Using SAS

    DEFF Research Database (Denmark)

    Lenth, Russell V; Højsgaard, Søren

    2007-01-01

    SASweave is a collection of scripts that allow one to embed SAS code into a LATEX document, and automatically incorporate the results as well. SASweave is patterned after Sweave, which does the same thing for code written in R. In fact, a document may contain both SAS and R code. Besides the conv...

  13. 46 CFR 308.520 - Standard optional endorsement No. 3, Form MA-300-C.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Standard optional endorsement No. 3, Form MA-300-C. 308.520 Section 308.520 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY... Standard optional endorsement No. 3, Form MA-300-C. Standard Optional Endorsement No. 3, which may...

  14. Applied medical statistics using SAS

    CERN Document Server

    Der, Geoff

    2012-01-01

    ""Each chapter in the book is well laid out, contains examples with SAS code, and ends with a concise summary. The chapters in the book contain the right level of information to use SAS to apply different statistical methods. … a good overview of how to apply in SAS 9.3 the many possible statistical analysis methods.""-Caroline Kennedy, Takeda Development Centre Europe Ltd., Statistical Methods for Medical Research, 2015""… a well-organized and thorough exploration of broad coverage in medical statistics. The book is an excellent reference of statistical methods

  15. Nye grafiske muligheder i SAS

    DEFF Research Database (Denmark)

    Milhøj, Anders

    2009-01-01

    Den vigtigste i SAS version 9.2 indenfor grafik er mulighederne for at producere dokumentationsgrafik i mange statistiske procedurer. Det drejer sig især om grafikker til modelkontrol, fx. residualdiagrammer, influensplot, normalfraktildiagrammer for residualerne etc.......Den vigtigste i SAS version 9.2 indenfor grafik er mulighederne for at producere dokumentationsgrafik i mange statistiske procedurer. Det drejer sig især om grafikker til modelkontrol, fx. residualdiagrammer, influensplot, normalfraktildiagrammer for residualerne etc....

  16. SAS FORMATS: USES AND ABUSES

    Science.gov (United States)

    SAS formats are a very powerful tool. They allow you to display the data in a more readable manner without modifying it. Formats can also be used to group data into categories for use in various procedures like PROC FREQ, PROC TTEST, and PROC MEANS (as a class variable). As ...

  17. SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae.

    OpenAIRE

    Xu, E. Y; S. Kim; Rivier, D H

    1999-01-01

    Sir2p, Sir3p, Sir4p, and the core histones form a repressive chromatin structure that silences transcription in the regions near telomeres and at the HML and HMR cryptic mating-type loci in Saccharomyces cerevisiae. Null alleles of SAS4 and SAS5 suppress silencing defects at HMR; therefore, SAS4 and SAS5 are negative regulators of silencing at HMR. This study revealed that SAS4 and SAS5 contribute to silencing at HML and the telomeres, indicating that SAS4 and SAS5 are positive regulators of ...

  18. The 23 to 300 C demagnetization resistance of samarium-cobalt permanent magnets

    Science.gov (United States)

    Niedra, Janis M.; Overton, Eric

    1991-01-01

    The influence of temperature on knee point and squareness of the M-H demagnetization characteristic of permanent magnets is important information for the full utilization of the capabilities of samarium-cobalt magnets at high temperature in demagnetization resistent permanent magnet devices. Composite plots of the knee field and the demagnetizing field required to produce a given magnetic induction swing below remanence were obtained for several commercial Sm2Co17 type magnet samples in the temperature range of 23 to 300 C. Using the knee point to define the limits of operation safe against irreversible demagnetization, such plots are shown to provide an effective overview of the useable regions in the space of temperature-induction swing parameters. The observed second quadrant M-H characteristic squareness is shown, by two measures, to increase gradually with temperature, reaching a peak in the interval 200 to 300 C.

  19. What's new in SAS 9.3

    DEFF Research Database (Denmark)

    Milhøj, Anders

    2012-01-01

    I foråret 2010 blev den ny SAS version SAS 9.22 lanceret som en opdatering af SAS 9.2, med væsentlige nye muligheder for netop statistik. Her i sommeren 2011 blev version 9.3 så lanceret med endnu flere nyskabelser i både generel performance og specielt indenfor statistik, økonometri og...

  20. Thanks to CERN's team of surveyors, the Organization's stand at the Night of Science attracted a large number of visitors : the technology and tools used by the surveyors, such as the Terrameter shown here, attracted many visitors to the CERN stand

    CERN Multimedia

    2004-01-01

    Thanks to CERN's team of surveyors, the Organization's stand at the Night of Science attracted a large number of visitors : the technology and tools used by the surveyors, such as the Terrameter shown here, attracted many visitors to the CERN stand

  1. Conducting Meta-Analysis Using SAS

    CERN Document Server

    Arthur, Winfried; Huffcutt, Allen I; Arthur, Winfred

    2001-01-01

    Conducting Meta-Analysis Using SAS reviews the meta-analysis statistical procedure and shows the reader how to conduct one using SAS. It presents and illustrates the use of the PROC MEANS procedure in SAS to perform the data computations called for by the two most commonly used meta-analytic procedures, the Hunter & Schmidt and Glassian approaches. This book serves as both an operational guide and user's manual by describing and explaining the meta-analysis procedures and then presenting the appropriate SAS program code for computing the pertinent statistics. The practical, step-by-step instru

  2. SAS : kosheljok ili proshtshai, Estonian Air!

    Index Scriptorium Estoniae

    2008-01-01

    Lennukompanii SAS saatis Eesti valitsusele kirja, milles teatab, et on nõus raskustesse sattunud Estonian Airile lisainvesteeringuid tegema ainult siis, kui valitsus müüb SAS-ile oma osaluse. Ettevõtjate, parlamendiliige Marko Mihkelsoni ja ministrite arvamusi

  3. A SAS IML Macro for Loglinear Smoothing

    Science.gov (United States)

    Moses, Tim; von Davier, Alina

    2011-01-01

    Polynomial loglinear models for one-, two-, and higher-way contingency tables have important applications to measurement and assessment. They are essentially regarded as a smoothing technique, which is commonly referred to as loglinear smoothing. A SAS IML (SAS Institute, 2002a) macro was created to implement loglinear smoothing according to…

  4. The SAS-3 delayed command system

    Science.gov (United States)

    Hoffman, E. J.

    1975-01-01

    To meet the requirements arising from the increased complexity of the power, attitude control and telemetry systems, a full redundant high-performance control section with delayed command capability was designed for the Small Astronomy Satellite-3 (SAS-3). The relay command system of SAS-3 is characterized by 56 bystate relay commands, with capability for handling up to 64 commands in future versions. The 'short' data command service of SAS-1 and SAS-2 consisting of shifting 24-bit words to two users was expanded to five users and augmented with a 'long load' data command service (up to 4080 bits) used to program the telemetry system and the delayed command subsystem. The inclusion of a delayed command service ensures a program of up to 30 relay or short data commands to be loaded for execution at designated times. The design and system operation of the SAS-3 command section are analyzed, with special attention given to the delayed command subsystem.

  5. The SAS-3 programmable telemetry system

    Science.gov (United States)

    Peterson, M. R.

    1975-01-01

    Basic concept, system design and operation principles of the telemetry system developed for the Small Astronomy Satellite-3 (SAS-3) are analyzed. The concept of programmable format selected for the SAS-3 represents an optical combination of the fixed format system of SAS-1 and SAS-2, and the adaptive format concept. The programmable telemetry system permits a very wide range of changes in the data sampling order by a ground control station, depending on the experimental requirements, so that the maximal amount of useful data can be returned from orbit. The programmable system also allows the data format to differ from one spacecraft to another without changing hardware. Attention is given to the command requirements and redundancy of the SAS-3 telemetry system.

  6. Recrystallization and superplasticity at 300 C in an aluminum-magnesium alloy

    Science.gov (United States)

    Hales, S. J.; Mcnelley, T. R.; Mcqueen, H. J.

    1991-01-01

    Variations in thermomechanical processing (TMP) which regulate the microstructural characteristics and superplastic response of an Al-10Mg-0.1Zr alloy at 300 C were evaluated. Mechanical property data revealed that the superplastic ductility can be enhanced by simultaneously increasing the total rolling strain, the reduction per pass, and the duration of reheating intervals between passes during isothermal rolling. Texture and microscopy data were consistent with the development of a refined microstructure by recovery-dominated processes, i.e., continuous recrystallization, during the processing. The mechanisms by which a refined substructure can be progressively converted into a fine-grained structure during repeated cycles of deformation and annealing are addressed. A qualitative description of the complex sequence of developments leading to a microstructure better suited to support superplastic response is presented.

  7. Extending and Enhancing SAS (Static Analysis Suite)

    CERN Document Server

    Ho, David

    2016-01-01

    The Static Analysis Suite (SAS) is an open-source software package used to perform static analysis on C and C++ code, helping to ensure safety, readability and maintainability. In this Summer Student project, SAS was enhanced to improve ease of use and user customisation. A straightforward method of integrating static analysis into a project at compilation time was provided using the automated build tool CMake. The process of adding checkers to the suite was streamlined and simplied by developing an automatic code generator. To make SAS more suitable for continuous integration, a reporting mechanism summarising results was added. This suitability has been demonstrated by inclusion of SAS in the Future Circular Collider Software nightly build system. Scalability of the improved package was demonstrated by using the tool to analyse the ROOT code base.

  8. Key Performance Indicators for SAS Flights

    OpenAIRE

    Arhall, Johanna; Cox, Emmie

    2013-01-01

    Revenue management is a thoroughly researched field of study and it is widely used in several different industries. The Revenue Management Department at the airline SAS (Scandinavian Airline System) serves to maximise the profit of the company’s flights. At their disposal they have a number of tools, which use KPIs (Key Performance Indicators) as a measurement. The KPIs are used in prognosis to determine future initiatives, and to analyse and verify results. SAS does not know if the KPIs they...

  9. Test plan using the HTTR for commercialization of GTHTR300C

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-10-15

    The high temperature engineering test reactor (HTTR) is the first high temperature gas-cooled reactor (HTGR) built at the Oarai Research and Development Center of Japan Atomic Energy Agency with thermal power of 30 MW and the maximum reactor outlet coolant temperature of 950 C. The HTTR achieved the first criticality in 1998, the reactor outlet coolant temperature of 950 C in 2004, and 30 days continuous operation in 2007 and 50 days continuous operation in 2010. Since 2002, safety demonstration tests including reactivity insertion tests and coolant flow reduction tests have been conducted to show inherent safety features of HTGR s. This report describes the future test plan by using the HTTR. The test items cover reactor thermal hydraulics and plant dynamics such as loss of forced cooling tests, loss of heat load tests, rapid increase of forced cooling tests and measurement of core flow and temperature distribution, etc. The test results will be utilized for realization of Japan's commercial very high temperature reactor (VHTR) system, GTHTR300C and the Gen IV HTGR activities. (Author)

  10. SAS doctors career progression survey 2013.

    Science.gov (United States)

    Oroz, Carlos; Sands, Lorna R; Lee, John

    2016-03-01

    We conducted a national survey of Staff, Associate Specialists and Specialty (SAS) doctors working in sexual health clinics in the UK in 2013 in order to explore their career progression. The aim of the survey was to assess SAS doctors' experience in passing through the thresholds and to gather information about the adherence by SAS doctors and employers to the terms and conditions of service laid out by the new 2008 contract. Out of 185 responders, whom the authors estimate comprise 34% of the total workforce, 159 were on the new contract. Of those, most SAS doctors were women (84%), the majority (67%) worked less than nine programmed activities per week; only a few had intentions to join the consultant grade (15%), and a considerable minority (26%) were older than 54 years of age and likely to retire in the next ten years. The survey showed that most participating SAS doctors had undergone appraisal in the previous 15 months (90%), most had a job planning discussion (83%) with their employer and most had some allocated time for supporting professional activities (86%). However, a significant minority had no appraisal (10%), no job planning discussion (17%) and had no allocated supporting professional activities (14%), which allows time for career development in the specialty. Most SAS doctors, who had the opportunity, had progressed through the thresholds automatically (88%); some experienced difficulties in passing (8%) and only a few did not pass (4%). SAS doctors must ensure that they work together with their employer in order to improve adherence to the terms and conditions of service of the contract, which allow for career progression and benefit both the individual doctors and ultimately service provision.

  11. Electrical conductivity and hardness of ternary Ge-In-Sb alloys and calculation of the isothermal section at 300 C

    Energy Technology Data Exchange (ETDEWEB)

    Premovic, Milena; Minic, Dusko; Mitrovica, Kosovska [Pristina Univ., Kosovska Mitrovica (Serbia). Faculty of Technical Science; Manasijevic, Ivana; Zivkovic, Dragana [Belgrade Univ., Bor (Serbia). Dept. of Metallurgical Engineering

    2015-07-01

    This publication presents results of experimental investigation and thermodynamic calculation of the ternary Ge-In-Sb system. Isothermal section of the Ge-In-Sb system at 300 C has been extrapolated using optimized thermodynamic parameters for the constitutive binary systems. Microstructure analysis was carried out by light microscope, scanning electron microscopy with energy dispersive spectrometry and X-ray powder diffraction methods and obtained results were compared with predicted phase equilibria. Hardness of selected alloys annealed at 300 C was measured using Vickers microhardness test and Brinell hardness test. Electrical conductivity of a number of alloys annealed at 300 C was experimentally determined. Good overall agreement between experimental and calculated values was obtained.

  12. The SAS-3 X-ray observatory

    Science.gov (United States)

    Mayer, W. F.

    1975-01-01

    The experiment section of the Small Astronomy Satellite-3 (SAS-3) launched in May 1975 is an X-ray observatory intended to determine the location of bright X-ray sources to an accuracy of 15 arc-seconds; to study a selected set of sources over a wide energy range, from 0.1 to 55 keV, while performing very specific measurements of the spectra and time variability of known X-ray sources; and to monitor the sky continuously for X-ray novae, flares, and unexpected phenomena. The improvements in SAS-3 spacecraft include a clock accurate to 1 part in 10 billion, rotatable solar panels, a programmable data format, and improved nutation damper, a delayed command system, improved magnetic trim and azimuth control systems. These improvements enable SAS-3 to perform three-axis stabilized observations of any point on the celestial sphere at any time of the year. The description of the experiment section and the SAS-3 operation is followed by a synopsis of scientific results obtained from the observations of X-ray sources, such as Vela X-1 (supposed to be an accreting neutron star), a transient source of hard X-ray (less than 36 min in duration) detected by SAS-3, the Crab Nebula pulsar, the Perseus cluster of galaxies, and the Vela supernova remnant.

  13. M-H characteristics and demagnetization resistance of samarium-cobalt permanent magnets to 300 C

    Science.gov (United States)

    Niedra, Janis M.

    1992-01-01

    The influence of temperature on the M-H demagnetization characteristics of permanent magnets is important information for the full utilization of the capabilities of samarium-cobalt magnets at high temperatures in demagnetization-resistant permanent magnet devices. In high temperature space power converters, such as free-piston Stirling engine driven linear alternators, magnet demagnetization can occur as a long-term consequence of thermal agitation of domains and of metallurgical change, and also as an immediate consequence of too large an applied field. Investigated here is the short-term demagnetization resistance to applied fields derived from basic M-H data. This quasistatic demagnetization data was obtained for commercial, high-intrinsic-coercivity, Sm2Co17-type magnets from 5 sources, in the temperature range 23 to 300 C. An electromagnet driven, electronic hysteresigraph was used to test the 1-cm cubic samples. The observed variation of the 2nd quadrant M-H characteristics was a typical rapid loss of M-coercivity and a relatively lesser loss of remanence with increasing temperature. The 2nd quadrant M-H curve knee point is used to define the limits of operation safe against irreversible demagnetization due to an excessive bucking field for a given flux density swing at temperature. Such safe operating area plots are shown to differentiate the high temperature capabilities of the samples from different sources. For most of the samples, their 2nd quadrant M-H loop squareness increased with temperature, reaching a peak or a plateau above 250 C.

  14. SAS-2 galactic gamma ray results, 1

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Hartman, R. C.; Kniffen, D. A.; Bignami, G. F.; Lamb, R. C.; Oegelman, H.; Oezel, M. E.; Tuemer, T.

    1976-01-01

    Continuing analysis of the data from the SAS-2 high energy gamma-ray experiment has produced an improved picture of the sky at photon energies above 35 MeV. On a large scale, the diffuse emission from the galactic plane is the dominant feature observed by SAS-2. This galactic plane emission is most intense between galactic longitude 310 and 45 deg, corresponding to a region within 7kpc of the galactic center. Within the high-intensity region, SAS-2 observes peaks around galactic longitudes 315 deg, 330 deg, 345 deg, 0 deg, and 35 deg. These peaks appear to be correlated with such galactic features and components as molecular hydrogen, atomic hydrogen, magnetic fields, cosmic ray concentrations, and photon fields.

  15. Statistical hypothesis testing with SAS and R

    CERN Document Server

    Taeger, Dirk

    2014-01-01

    A comprehensive guide to statistical hypothesis testing with examples in SAS and R When analyzing datasets the following questions often arise:Is there a short hand procedure for a statistical test available in SAS or R?If so, how do I use it?If not, how do I program the test myself? This book answers these questions and provides an overview of the most commonstatistical test problems in a comprehensive way, making it easy to find and performan appropriate statistical test. A general summary of statistical test theory is presented, along with a basicdescription for each test, including the

  16. SAS wave experiment on board Magion 4

    Directory of Open Access Journals (Sweden)

    J. Błęcki

    Full Text Available A short description of the SAS (subsatellite analyser of spectra wave experiment on board the Magion-4 subsatellite is given. We present first measurements of the magnetic-field fluctuations in the frequency range 32–2000 Hz obtained in the magnetotail during the disturbed period at the magnetopause and in the polar cusp.

  17. Beijing, the SAS Gateway to China

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Scandinavian Airlines has launched the direct route from Stockholm to Beijing.China's Foreign Trade had an interview with Mr. Lars Lindgren,CEO of Scandinavian Airlines International (SAS).He pointed out that they expect to see that all across Scandinavia will be opened to China,and before long Beijing will become Scandinavian Airlines' gateway to China. The follows are the interview.

  18. The SAS-3 power and thermal systems

    Science.gov (United States)

    Sullivan, R. M.; Hogrefe, A. F.; Brenza, P. T.

    1975-01-01

    Solar array configurations of the SAS-3 are described: a configuration with two sets of coplanar panels in the horizontal and two others in the vertical position, and two other configurations with either four horizontal or four vertical sets of panels. The nickel-cadmium battery of the power subsystem is described in detail, with emphasis on voltage limits and charge-discharge characteristics. The characteristic of 'solar-only' operation in the case of damage to the battery is discussed. The thermal subsystem of SAS-3 is considered, with discussions of thermal design criteria and the thermal environment. Temperature is controlled by using internal thermal louvers that regulate the rate at which the heat load from electronic equipment is transmitted to the outer surface for dumping to space.

  19. Fitting polytomous Rasch models in SAS

    DEFF Research Database (Denmark)

    Christensen, Karl Bang

    2006-01-01

    The item parameters of a polytomous Rasch model can be estimated using marginal and conditional approaches. This paper describes how this can be done in SAS (V8.2) for three item parameter estimation procedures: marginal maximum likelihood estimation, conditional maximum likelihood estimation......, and pairwise conditional estimation. The use of the procedures for extensions of the Rasch model is also discussed. The accuracy of the methods are evaluated using a simulation study....

  20. Design and analysis of experiments with SAS

    CERN Document Server

    Lawson, John

    2010-01-01

    IntroductionStatistics and Data Collection Beginnings of Statistically Planned Experiments Definitions and Preliminaries Purposes of Experimental Design Types of Experimental Designs Planning Experiments Performing the Experiments Use of SAS SoftwareCompletely Randomized Designs with One Factor Introduction Replication and Randomization A Historical Example Linear Model for Completely Randomized Design (CRD) Verifying Assumptions of the Linear Model Analysis Strategies When Assumptions Are Violated Determining the Number of Replicates Comparison of Treatments after the F-TestFactorial Designs

  1. Colombian Safe Guide S.A.S

    OpenAIRE

    2012-01-01

    Colombian Safe Guide S.A.S. es una compañía de servicios de asesoramiento y acompañamiento a los visitantes extranjeros que vienen a la ciudad de Bogotá. Funciona a través de una página web, que facilitan a sus clientes la obtención de todos los servicios necesarios durante su estadía, en un solo lugar. El principal objetivo es proporcionar nuevas alternativas de servicios de asesoramiento, capitalizando la compañía bajo el cumplimiento del objetivo y cuota del mercado propuesta por la compañ...

  2. The SAS-3 attitude control system

    Science.gov (United States)

    Mobley, F. F.; Konigsberg, R.; Fountain, G. H.

    1975-01-01

    SAS-3 uses a reaction wheel to provide torque to control the spin rate. If the wheel speed becomes too great or too small, it must be restored to its nominal rate by momentum dumping which is done by magnetic torquing against the earth's magnetic field by the satellite's magnetic coils. A small rate-integrating gyro is used to sense the spin rate so that closed loop control of the spin rate can be achieved. These various systems are described in detail including the reaction wheel system, the gyro system, along with control modes (spin rate control and the star lock mode).

  3. SAS-Expander and Its Realization%SAS-Expander及其实现

    Institute of Scientific and Technical Information of China (English)

    王宇

    2009-01-01

    SAS(Serial Attached SCSI)即串行SCSI技术,是一种磁盘连接技术.而Expander本质上就是SAS交换机,可以将多个SAS连接到有限数量的主机端口上.这里主要介绍了通过MAX-IM公司的VSC7154实现SAS-Expander磁盘阵列柜.此阵列柜机构部件依据SBB规范实现.

  4. Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly.

    Science.gov (United States)

    Lettman, Molly M; Wong, Yao Liang; Viscardi, Valeria; Niessen, Sherry; Chen, Sheng-Hong; Shiau, Andrew K; Zhou, Huilin; Desai, Arshad; Oegema, Karen

    2013-05-13

    Assembly of SAS-6 dimers to form the centriolar cartwheel requires the ZYG-1/Plk4 kinase. Here, we show that ZYG-1 recruits SAS-6 to the mother centriole independently of its kinase activity; kinase activity is subsequently required for cartwheel assembly. We identify a direct interaction between ZYG-1 and the SAS-6 coiled coil that explains its kinase activity-independent function in SAS-6 recruitment. Perturbing this interaction, or the interaction between an adjacent segment of the SAS-6 coiled coil and SAS-5, prevented SAS-6 recruitment and cartwheel assembly. SAS-6 mutants with alanine substitutions in a previously described ZYG-1 target site or in 37 other residues, either phosphorylated by ZYG-1 in vitro or conserved in closely related nematodes, all supported cartwheel assembly. We propose that ZYG-1 binding to the SAS-6 coiled coil recruits the SAS-6-SAS-5 complex to the mother centriole, where a ZYG-1 kinase activity-dependent step, whose target is unlikely to be SAS-6, triggers cartwheel assembly.

  5. Composites reinforcement by rods: a SAS study

    Energy Technology Data Exchange (ETDEWEB)

    Urban, V. [ESRF, BP220, 38043 Grenoble Cedex (France); Botti, A.; Pyckhout-Hintzen, W.; Richter, D. [IFF-Forschungszentrum Juelich, 52425 Juelich (Germany); Straube, E. [University of Halle, FB Physik, 06099 Halle (Germany)

    2002-07-01

    The mechanical properties of composites are governed by size, shape and dispersion degree of so-called reinforcing particles. Polymeric fillers based on thermodynamically driven microphase separation of block copolymers offer the opportunity to study a model system of controlled rod-like filler particles. We chose a triblock copolymer (PBPSPB) and carried out SAS measurements with both X-rays and neutrons, in order to characterize separately the hard phase and the cross-linked PB matrix. The properties of the material depend strongly on the way that stress is carried and transferred between the soft matrix and the hard fibers. The failure of the strain-amplification concept and the change of topological contributions to the free energy and scattering factor have to be addressed. In this respect the composite shows a similarity to a two-network system, i.e. interpenetrating rubber and rod-like filler networks. (orig.)

  6. Composites reinforcement by rods a SAS study

    CERN Document Server

    Urban, V; Pyckhout-Hintzen, W; Richter, D; Straube, E

    2002-01-01

    The mechanical properties of composites are governed by size, shape and dispersion degree of so-called reinforcing particles. Polymeric fillers based on thermodynamically driven microphase separation of block copolymers offer the opportunity to study a model system of controlled rod-like filler particles. We chose a triblock copolymer (PBPSPB) and carried out SAS measurements with both X-rays and neutrons, in order to characterize separately the hard phase and the cross-linked PB matrix. The properties of the material depend strongly on the way that stress is carried and transferred between the soft matrix and the hard fibers. The failure of the strain-amplification concept and the change of topological contributions to the free energy and scattering factor have to be addressed. In this respect the composite shows a similarity to a two-network system, i.e. interpenetrating rubber and rod-like filler networks. (orig.)

  7. Regression modeling methods, theory, and computation with SAS

    CERN Document Server

    Panik, Michael

    2009-01-01

    Regression Modeling: Methods, Theory, and Computation with SAS provides an introduction to a diverse assortment of regression techniques using SAS to solve a wide variety of regression problems. The author fully documents the SAS programs and thoroughly explains the output produced by the programs.The text presents the popular ordinary least squares (OLS) approach before introducing many alternative regression methods. It covers nonparametric regression, logistic regression (including Poisson regression), Bayesian regression, robust regression, fuzzy regression, random coefficients regression,

  8. SAS and R data management, statistical analysis, and graphics

    CERN Document Server

    Kleinman, Ken

    2014-01-01

    An Up-to-Date, All-in-One Resource for Using SAS and R to Perform Frequent TasksThe first edition of this popular guide provided a path between SAS and R using an easy-to-understand, dictionary-like approach. Retaining the same accessible format, SAS and R: Data Management, Statistical Analysis, and Graphics, Second Edition explains how to easily perform an analytical task in both SAS and R, without having to navigate through the extensive, idiosyncratic, and sometimes unwieldy software documentation. The book covers many common tasks, such as data management, descriptive summaries, inferentia

  9. Adaptive beamforming for low frequency SAS imagery and bathymetry

    NARCIS (Netherlands)

    Hayes, M.P.; Hunter, A.J.

    2012-01-01

    Synthetic aperture side-scan sonar (SAS) is a mature technology for high-resolution sea floor imaging [1]. Interferometric synthetic aperture sonars (InSAS) use additional hydrophones in a vertical array for bathymetric mapping [2]. This has created high-resolution bathymetry in deep water environme

  10. Adaptive beamforming for low frequency SAS imagery and bathymetry

    NARCIS (Netherlands)

    Hayes, M.P.; Hunter, A.J.

    2012-01-01

    Synthetic aperture side-scan sonar (SAS) is a mature technology for high-resolution sea floor imaging [1]. Interferometric synthetic aperture sonars (InSAS) use additional hydrophones in a vertical array for bathymetric mapping [2]. This has created high-resolution bathymetry in deep water

  11. Hotelli Radisson SAS mantra : jah, ma saan! / Kai Vare

    Index Scriptorium Estoniae

    Vare, Kai, 1968-

    2004-01-01

    Radisson SAS hotell Tallinnas on kliendirahulolu-uuringute järgi keti hotellide seas esimeste hulgas. Hotelli direktor Kaido Ojaperv ja müügijuht Ann-Kai Tõrs Radisson SAS-i standarditest, kliendi sajaprotsendilise rahulolu tagamise põhimõtetest, personali valikust, koolitusest. Kommenteerib Sandra Dimitrovich

  12. SAS-6 coiled-coil structure and interaction with SAS-5 suggest a regulatory mechanism in C. elegans centriole assembly.

    Science.gov (United States)

    Qiao, Renping; Cabral, Gabriela; Lettman, Molly M; Dammermann, Alexander; Dong, Gang

    2012-11-14

    The centriole is a conserved microtubule-based organelle essential for both centrosome formation and cilium biogenesis. Five conserved proteins for centriole duplication have been identified. Two of them, SAS-5 and SAS-6, physically interact with each other and are codependent for their targeting to procentrioles. However, it remains unclear how these two proteins interact at the molecular level. Here, we demonstrate that the short SAS-5 C-terminal domain (residues 390-404) specifically binds to a narrow central region (residues 275-288) of the SAS-6 coiled coil. This was supported by the crystal structure of the SAS-6 coiled-coil domain (CCD), which, together with mutagenesis studies, indicated that the association is mediated by synergistic hydrophobic and electrostatic interactions. The crystal structure also shows a periodic charge pattern along the SAS-6 CCD, which gives rise to an anti-parallel tetramer. Overall, our findings establish the molecular basis of the specific interaction between SAS-5 and SAS-6, and suggest that both proteins individually adopt an oligomeric conformation that is disrupted upon the formation of the hetero-complex to facilitate the correct assembly of the nine-fold symmetric centriole.

  13. SAS and R data management, statistical analysis, and graphics

    CERN Document Server

    Kleinman, Ken

    2009-01-01

    An All-in-One Resource for Using SAS and R to Carry out Common TasksProvides a path between languages that is easier than reading complete documentationSAS and R: Data Management, Statistical Analysis, and Graphics presents an easy way to learn how to perform an analytical task in both SAS and R, without having to navigate through the extensive, idiosyncratic, and sometimes unwieldy software documentation. The book covers many common tasks, such as data management, descriptive summaries, inferential procedures, regression analysis, and the creation of graphics, along with more complex applicat

  14. Substrate Activity Screening (SAS) and Related Approaches in Medicinal Chemistry.

    Science.gov (United States)

    Gladysz, Rafaela; Lambeir, Anne-Marie; Joossens, Jurgen; Augustyns, Koen; Van der Veken, Pieter

    2016-03-04

    Substrate activity screening (SAS) was presented a decade ago by Ellman and co-workers as a straightforward methodology for the identification of fragment-sized building blocks for enzyme inhibitors. Ever since, SAS and variations derived from it have been successfully applied to the discovery of inhibitors of various families of enzymatically active drug targets. This review covers key achievements and challenges of SAS and related methodologies, including the modified substrate activity screening (MSAS) approach. Special attention is given to the kinetic and thermodynamic aspects of these methodologies, as a thorough understanding thereof is crucial for successfully transforming the identified fragment-sized hits into potent inhibitors.

  15. Usual Dietary Intakes: SAS Macros for the NCI Method

    Science.gov (United States)

    SAS macros are currently available to facilitate modeling of a single dietary component, whether consumed daily or episodically; ratios of two dietary components that are consumed nearly every day; multiple dietary components, whether consumed daily or episodically.

  16. Breast Cancer Risk Assessment SAS Macro (Gail Model)

    Science.gov (United States)

    A SAS macro (commonly referred to as the Gail Model) that projects absolute risk of invasive breast cancer according to NCI’s Breast Cancer Risk Assessment Tool (BCRAT) algorithm for specified race/ethnic groups and age intervals.

  17. Islandlased tahavad SAS-i Skandinaavia turult kukutada / Mikk Salu

    Index Scriptorium Estoniae

    Salu, Mikk, 1975-

    2006-01-01

    Islandlastele kuuluv investeerimisfirma FL Grupp koondab lennufirmasid, et haarata liidrirolli Põhjala lennunduses. Lisad: Island; Islandi rikkaim mees; Uus põlvkond. Diagrammid: Islandi lennuärimehed versus SAS

  18. Structure of the SAS-6 cartwheel hub from Leishmania major.

    Science.gov (United States)

    van Breugel, Mark; Wilcken, Rainer; McLaughlin, Stephen H; Rutherford, Trevor J; Johnson, Christopher M

    2014-01-01

    Centrioles are cylindrical cell organelles with a ninefold symmetric peripheral microtubule array that is essential to template cilia and flagella. They are built around a central cartwheel assembly that is organized through homo-oligomerization of the centriolar protein SAS-6, but whether SAS-6 self-assembly can dictate cartwheel and thereby centriole symmetry is unclear. Here we show that Leishmania major SAS-6 crystallizes as a 9-fold symmetric cartwheel and provide the X-ray structure of this assembly at a resolution of 3.5 Å. We furthermore demonstrate that oligomerization of Leishmania SAS-6 can be inhibited by a small molecule in vitro and provide indications for its binding site. Our results firmly establish that SAS-6 can impose cartwheel symmetry on its own and indicate how this process might occur mechanistically in vivo. Importantly, our data also provide a proof-of-principle that inhibition of SAS-6 oligomerization by small molecules is feasible. DOI: http://dx.doi.org/10.7554/eLife.01812.001.

  19. A SAS Package for Logistic Two-Phase Studies

    Directory of Open Access Journals (Sweden)

    Walter Schill

    2014-04-01

    Full Text Available Two-phase designs, in which for a large study a dichotomous outcome and partial or proxy information on risk factors is available, whereas precise or complete measurements on covariates have been obtained only in a stratified sub-sample, extend the standard case-control design and have been proven useful in practice. The application of two-phase designs, however, seems to be hampered by the lack of appropriate, easy-to-use software. This paper introduces sas-twophase-package, a collection of SAS-macros, to fulfill this task. sas-twophase-package implements weighted likelihood, pseudo likelihood and semi- parametric maximum likelihood estimation via the EM algorithm and via profile likelihood in two-phase settings with dichotomous outcome and a given stratification.

  20. Social Anxiety Scale for Adolescents (SAS-A) Short Form.

    Science.gov (United States)

    Nelemans, Stefanie A; Meeus, Wim H J; Branje, Susan J T; Van Leeuwen, Karla; Colpin, Hilde; Verschueren, Karine; Goossens, Luc

    2017-01-01

    In this study, we examined the longitudinal measurement invariance of a 12-item short version of the Social Anxiety Scale for Adolescents (SAS-A) in two 4-year longitudinal community samples ( Nsample 1 = 815, Mage T1 = 13.38 years; Nsample 2 = 551, Mage T1 = 14.82 years). Using confirmatory factor analyses, we found strict longitudinal measurement invariance for the three-factor structure of the SAS-A across adolescence, across samples, and across gender. Some developmental changes in social anxiety were found from early to mid-adolescence, as well as gender differences across adolescence. These findings suggest that the short version of the SAS-A is a developmentally appropriate instrument that can be used effectively to examine adolescent social anxiety development.

  1. SAS-2 galactic gamma-ray results. 1: Diffuse emission

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Hartman, R. C.; Kniffen, D. A.; Bignami, G. F.; Lamb, R. C.; Oegelman, H.; Oezel, M. E.; Tuemer, T.

    1977-01-01

    Continuing analysis of the data from the SAS-2 high energy gamma ray experiment has produced an improved picture of the sky at photon energies above 35 MeV. On a large scale, the diffuse emission from the galactic plane is the dominant feature observed by SAS-2. This galactic plane emission is most intense between galactic longitudes 310 deg and 45 deg, corresponding to a region within 7 kpc of the galactic center. Within the high-intensity region, SAS-2 observes peaks around galactic longitudes 315, 330, 345, 0, and 35 deg. These peaks appear to be correlated with galactic features and components such as molecular hydrogen, atomic hydrogen, magnetic fields, cosmic-ray concentrations, and photon fields.

  2. Development and validation of a smartphone addiction scale (SAS.

    Directory of Open Access Journals (Sweden)

    Min Kwon

    Full Text Available OBJECTIVE: The aim of this study was to develop a self-diagnostic scale that could distinguish smartphone addicts based on the Korean self-diagnostic program for Internet addiction (K-scale and the smartphone's own features. In addition, the reliability and validity of the smartphone addiction scale (SAS was demonstrated. METHODS: A total of 197 participants were selected from Nov. 2011 to Jan. 2012 to accomplish a set of questionnaires, including SAS, K-scale, modified Kimberly Young Internet addiction test (Y-scale, visual analogue scale (VAS, and substance dependence and abuse diagnosis of DSM-IV. There were 64 males and 133 females, with ages ranging from 18 to 53 years (M = 26.06; SD = 5.96. Factor analysis, internal-consistency test, t-test, ANOVA, and correlation analysis were conducted to verify the reliability and validity of SAS. RESULTS: Based on the factor analysis results, the subscale "disturbance of reality testing" was removed, and six factors were left. The internal consistency and concurrent validity of SAS were verified (Cronbach's alpha = 0.967. SAS and its subscales were significantly correlated with K-scale and Y-scale. The VAS of each factor also showed a significant correlation with each subscale. In addition, differences were found in the job (p<0.05, education (p<0.05, and self-reported smartphone addiction scores (p<0.001 in SAS. CONCLUSIONS: This study developed the first scale of the smartphone addiction aspect of the diagnostic manual. This scale was proven to be relatively reliable and valid.

  3. Want independent validation and assurance? Ask for a SAS-70.

    Science.gov (United States)

    Boutin, Christopher C

    2008-08-01

    The AICPA's Statement on Auditing Standards No.70, Service Organizations addresses CPA audits of service providers conducted to verify that a provider has adequate controls over its operations. Hospitals should request a SAS-70, the report produced by such an audit, from all of their third-party service providers. SAS-70s can be issued for a specific date or for a six-month period, and they typically consist of three sections: a CPA opinion, a description of controls, and information about the design of the controls.

  4. Observations of A0620-00 by SAS-3

    Science.gov (United States)

    Bradt, H.; Matilsky, T.

    1976-01-01

    The transient X-ray source A0620-00 was observed by the SAS-3 group with the SAS-3 X-ray observatory. At maximum X-ray luminosity limits of 2% were placed on periodic variations from 0.2 ms - 2,000 sec. A precise position was obtained with the rotating modulation collimator. This led directly to radio and optical identification by groups at the NRAO, Arecibo, and McGraw Hill Observatories. The low energy (0.15-0.9 keV) system was pointed at the source, and a spectrum was derived. Hardness ratios are presented, as well as detailed light curves.

  5. Traitement des données par le logiciel SAS: introduction au module de base

    OpenAIRE

    Carletti, Isabelle; Prevot, Hugues

    2006-01-01

    Cette note constitue une introduction au module de base SAS. Après un bref aperçu de l'environnement de travail SAS et des principes du langage SAS, les étapes DATA et PROC d'un programme SAS sont exposées en plus en détails.

  6. SAS Radisson esitab Tallinnale väljakutse / Tõnis Arnover

    Index Scriptorium Estoniae

    Arnover, Tõnis, 1952-

    2000-01-01

    Tallinna Radisson SAS hotelli juht T. Bodin on kindel, et suudab pakkuda tipphotellile kohast teenindus. Vt. samas Mägus, Feliks. Hinnasõda hotellide vahel jääb ära. Ilmunud ka: Delovõje Vedomosti 1. nov. lk. 20-21

  7. Tubulin nucleotide status controls Sas-4-dependent pericentriolar material recruitment.

    Science.gov (United States)

    Gopalakrishnan, Jayachandran; Chim, Yiu-Cheung Frederick; Ha, Andrew; Basiri, Marcus L; Lerit, Dorothy A; Rusan, Nasser M; Avidor-Reiss, Tomer

    2012-08-01

    Regulated centrosome biogenesis is required for accurate cell division and for maintaining genome integrity. Centrosomes consist of a centriole pair surrounded by a protein network known as pericentriolar material (PCM). PCM assembly is a tightly regulated, critical step that determines the size and capability of centrosomes. Here, we report a role for tubulin in regulating PCM recruitment through the conserved centrosomal protein Sas-4. Tubulin directly binds to Sas-4; together they are components of cytoplasmic complexes of centrosomal proteins. A Sas-4 mutant, which cannot bind tubulin, enhances centrosomal protein complex formation and has abnormally large centrosomes with excessive activity. These results suggest that tubulin negatively regulates PCM recruitment. Whereas tubulin-GTP prevents Sas-4 from forming protein complexes, tubulin-GDP promotes it. Thus, the regulation of PCM recruitment by tubulin depends on its GTP/GDP-bound state. These results identify a role for tubulin in regulating PCM recruitment independent of its well-known role as a building block of microtubules. On the basis of its guanine-bound state, tubulin can act as a molecular switch in PCM recruitment.

  8. Using SAS PROC MCMC for Item Response Theory Models

    Science.gov (United States)

    Ames, Allison J.; Samonte, Kelli

    2015-01-01

    Interest in using Bayesian methods for estimating item response theory models has grown at a remarkable rate in recent years. This attentiveness to Bayesian estimation has also inspired a growth in available software such as WinBUGS, R packages, BMIRT, MPLUS, and SAS PROC MCMC. This article intends to provide an accessible overview of Bayesian…

  9. A SAS Interface for Bayesian Analysis with WinBUGS

    Science.gov (United States)

    Zhang, Zhiyong; McArdle, John J.; Wang, Lijuan; Hamagami, Fumiaki

    2008-01-01

    Bayesian methods are becoming very popular despite some practical difficulties in implementation. To assist in the practical application of Bayesian methods, we show how to implement Bayesian analysis with WinBUGS as part of a standard set of SAS routines. This implementation procedure is first illustrated by fitting a multiple regression model…

  10. A SAS/IML algorithm for an exact permutation test

    Directory of Open Access Journals (Sweden)

    Neuhäuser, Markus

    2009-03-01

    Full Text Available An algorithm written in SAS/IML is presented that can perform an exact permutation test for a two-sample comparison. All possible permutations are considered. The Baumgartner-Weiß-Schindler statistic is exemplarily used as the test statistic for the permutation test.

  11. SAS- Semantic Annotation Service for Geoscience resources on the web

    Science.gov (United States)

    Elag, M.; Kumar, P.; Marini, L.; Li, R.; Jiang, P.

    2015-12-01

    There is a growing need for increased integration across the data and model resources that are disseminated on the web to advance their reuse across different earth science applications. Meaningful reuse of resources requires semantic metadata to realize the semantic web vision for allowing pragmatic linkage and integration among resources. Semantic metadata associates standard metadata with resources to turn them into semantically-enabled resources on the web. However, the lack of a common standardized metadata framework as well as the uncoordinated use of metadata fields across different geo-information systems, has led to a situation in which standards and related Standard Names abound. To address this need, we have designed SAS to provide a bridge between the core ontologies required to annotate resources and information systems in order to enable queries and analysis over annotation from a single environment (web). SAS is one of the services that are provided by the Geosematnic framework, which is a decentralized semantic framework to support the integration between models and data and allow semantically heterogeneous to interact with minimum human intervention. Here we present the design of SAS and demonstrate its application for annotating data and models. First we describe how predicates and their attributes are extracted from standards and ingested in the knowledge-base of the Geosemantic framework. Then we illustrate the application of SAS in annotating data managed by SEAD and annotating simulation models that have web interface. SAS is a step in a broader approach to raise the quality of geoscience data and models that are published on the web and allow users to better search, access, and use of the existing resources based on standard vocabularies that are encoded and published using semantic technologies.

  12. A SAS-6-like protein suggests that the Toxoplasma conoid complex evolved from flagellar components.

    Science.gov (United States)

    de Leon, Jessica Cruz; Scheumann, Nicole; Beatty, Wandy; Beck, Josh R; Tran, Johnson Q; Yau, Candace; Bradley, Peter J; Gull, Keith; Wickstead, Bill; Morrissette, Naomi S

    2013-07-01

    SAS-6 is required for centriole biogenesis in diverse eukaryotes. Here, we describe a novel family of SAS-6-like (SAS6L) proteins that share an N-terminal domain with SAS-6 but lack coiled-coil tails. SAS6L proteins are found in a subset of eukaryotes that contain SAS-6, including diverse protozoa and green algae. In the apicomplexan parasite Toxoplasma gondii, SAS-6 localizes to the centriole but SAS6L is found above the conoid, an enigmatic tubulin-containing structure found at the apex of a subset of alveolate organisms. Loss of SAS6L causes reduced fitness in Toxoplasma. The Trypanosoma brucei homolog of SAS6L localizes to the basal-plate region, the site in the axoneme where the central-pair microtubules are nucleated. When endogenous SAS6L is overexpressed in Toxoplasma tachyzoites or Trypanosoma trypomastigotes, it forms prominent filaments that extend through the cell cytoplasm, indicating that it retains a capacity to form higher-order structures despite lacking a coiled-coil domain. We conclude that although SAS6L proteins share a conserved domain with SAS-6, they are a functionally distinct family that predates the last common ancestor of eukaryotes. Moreover, the distinct localization of the SAS6L protein in Trypanosoma and Toxoplasma adds weight to the hypothesis that the conoid complex evolved from flagellar components.

  13. CTTITEM: SAS macro and SPSS syntax for classical item analysis.

    Science.gov (United States)

    Lei, Pui-Wa; Wu, Qiong

    2007-08-01

    This article describes the functions of a SAS macro and an SPSS syntax that produce common statistics for conventional item analysis including Cronbach's alpha, item difficulty index (p-value or item mean), and item discrimination indices (D-index, point biserial and biserial correlations for dichotomous items and item-total correlation for polytomous items). These programs represent an improvement over the existing SAS and SPSS item analysis routines in terms of completeness and user-friendliness. To promote routine evaluations of item qualities in instrument development of any scale, the programs are available at no charge for interested users. The program codes along with a brief user's manual that contains instructions and examples are downloadable from suen.ed.psu.edu/-pwlei/plei.htm.

  14. Anatomy of the TAMA SAS seismic attenuation system

    CERN Document Server

    Marka, S; Ando, M; Bertolini, A; Cella, G; DeSalvo, R; Fukushima, M; Iida, Y; Jacquier, F; Kawamura, S; Nishi, Y; Numata, K; Sannibale, V; Somiya, K; Takahashi, R; Tariq, H; Tsubono, K; Ugas, J; Viboud, N; Wang Chen Yang; Yamamoto, H; Yoda, T

    2002-01-01

    The TAMA SAS seismic attenuation system was developed to provide the extremely high level of seismic isolation required by the next generation of interferometric gravitational wave detectors to achieve the desired sensitivity at low frequencies. Our aim was to provide good performance at frequencies above approx 10 Hz, while utilizing only passive subsystems in the sensitive frequency band of the TAMA interferometric gravitational wave detectors. The only active feedback is relegated below 6 Hz and it is used to damp the rigid body resonances of the attenuation chain. Simulations, based on subsystem performance characterizations, indicate that the system can achieve rms mirror residual motion measured in a few tens of nanometres. We will give a brief overview of the subsystems and point out some of the characterization results, supporting our claims of achieved performance. SAS is a passive, UHV compatible and low cost system. It is likely that extremely sensitive experiments in other fields will also profit ...

  15. SAS/QC在统计质量管理中的功能与应用

    Institute of Scientific and Technical Information of China (English)

    钟英莲

    2008-01-01

    在统计教学与实践中,对SAS系统的开发应用较多的是SAS/BASE、SAS/STAT、SAS/ETS等软件,而对于SAS/QC软件的开发应用尚属少见。本文将概括性地介绍SAS/QC软件在质量管理中的功能和作用,通过案例介绍SAS/QC在质量控制中的具体应用。

  16. Genome sequencing and annotation of Proteus sp. SAS71

    Directory of Open Access Journals (Sweden)

    Samy Selim

    2015-12-01

    Full Text Available We report draft genome sequence of Proteus sp. strain SAS71, isolated from water spring in Aljouf region, Saudi Arabia. The draft genome size is 3,037,704 bp with a G + C content of 39.3% and contains 6 rRNA sequence (single copies of 5S, 16S & 23S rRNA. The genome sequence can be accessed at DDBJ/EMBL/GenBank under the accession no. LDIU00000000.

  17. Combination of functional MRI with SAS and MRA

    Energy Technology Data Exchange (ETDEWEB)

    Sumida, Masayuki; Takeshita, Shinichirou; Kutsuna, Munenori; Akimitsu, Tomohide; Arita, Kazunori; Kurisu, Kaoru [Hiroshima Univ. (Japan). School of Medicine

    1999-02-01

    For presurgical diagnosis of brain surface, combination of functional MRI (fMRI) with the MR angiography was examined. This method could visualize brain bay, convolution and vein as index of surface. Five normal adults (male, mean age: 28-year-old) and 7 patients with brain tumor on the main locus to surface (male: 4, female: 3, mean age: 52.3-year-old) were studied. fMRI was performed by SPGR method (TR 70, TE 40, flip angle 60, one slice, thickness 10 mm, FOV 20 cm, matrix 128 x 128). The brain surface was visualized by SAS (surface anatomy scanning). SAS was performed by FSE method (TR 6000, TE 200, echo train 16, thickness 20 mm, slice 3, NEX 2). Cortical veins near superior sagittal sinus were visualized by MRA with 2D-TOF method (TR 50, TE 20, flip angle 60, thickness 2 mm, slice 28, NEX 1). These images were superimposed and functional image of peripheral sensorimotor region was evaluated anatomically. In normal adults, high signal was visualized at another side of near sensorimotor region at 8 of 10 sides. All high signal area of fMRI agreed with cortical vein near sensorimotor region that was visualized by MRA. In patients with brain tumor, signal was visualized at another side of sensorimotor region of tumor without 2 cases with palsy. In another side of tumor, signal of fMRI was visualized in 5 of 7 cases. The tumor was visualized as opposite low signal field in SAS. Locational relation between tumor and brain surface and brain function was visualized distinctly by combination of MRA, SAS and MRA. This method could become useful for presurgical diagnosis. (K.H.)

  18. Quality assurance management plan (QAPP) special analytical support (SAS)

    Energy Technology Data Exchange (ETDEWEB)

    LOCKREM, L.L.

    1999-05-20

    It is the policy of Special Analytical Support (SAS) that the analytical aspects of all environmental data generated and processed in the laboratory, subject to the Environmental Protection Agency (EPA), U.S. Department of Energy or other project specific requirements, be of known and acceptable quality. It is the intention of this QAPP to establish and assure that an effective quality controlled management system is maintained in order to meet the quality requirements of the intended use(s) of the data.

  19. Implementing the Law of Sines to solve SAS triangles

    CERN Document Server

    Zelator, Konstantine

    2010-01-01

    By "solving a triangle", one refers to determining the three sidelengths and the three angles, based on given information.Depending on the specific information, one or more triangles may satisfy the requirements of the given information.In the SAS case, two of sidelengths are given, as well as the angle contained by the two sides.According to Euclidean Geometry, such a triangle must be unique. In reference [1], and pretty much in standard trigonometry and precalculus texts,the Law of Cosines is employed in solving a SAS triangle. In this work we use an alternative approach by using the Law of Cosines.In Section 2, we list some basic trigonometric identities and in Section 3 we prove a lemma which is used in Section4. In Section4, we demonstrate the use of the Law of Sines in solving an SAS triangle. In Section 5 we offer three examples in detail; the last one being more general in nature.

  20. SPSS and SAS programming for the testing of mediation models.

    Science.gov (United States)

    Dudley, William N; Benuzillo, Jose G; Carrico, Mineh S

    2004-01-01

    Mediation modeling can explain the nature of the relation among three or more variables. In addition, it can be used to show how a variable mediates the relation between levels of intervention and outcome. The Sobel test, developed in 1990, provides a statistical method for determining the influence of a mediator on an intervention or outcome. Although interactive Web-based and stand-alone methods exist for computing the Sobel test, SPSS and SAS programs that automatically run the required regression analyses and computations increase the accessibility of mediation modeling to nursing researchers. To illustrate the utility of the Sobel test and to make this programming available to the Nursing Research audience in both SAS and SPSS. The history, logic, and technical aspects of mediation testing are introduced. The syntax files sobel.sps and sobel.sas, created to automate the computation of the regression analysis and test statistic, are available from the corresponding author. The reported programming allows the user to complete mediation testing with the user's own data in a single-step fashion. A technical manual included with the programming provides instruction on program use and interpretation of the output. Mediation modeling is a useful tool for describing the relation between three or more variables. Programming and manuals for using this model are made available.

  1. Usual Dietary Intakes: SAS Macros for Fitting Multivariate Measurement Error Models & Estimating Multivariate Usual Intake Distributions

    Science.gov (United States)

    The following SAS macros can be used to create a multivariate usual intake distribution for multiple dietary components that are consumed nearly every day or episodically. A SAS macro for performing balanced repeated replication (BRR) variance estimation is also included.

  2. SAS-macros for estimation and prediction in an model of the electricity consumption

    DEFF Research Database (Denmark)

    1998-01-01

    SAS-macros for estimation and prediction in an model of the electricity consumption'' is a large collection of SAS-macros for handling a model of the electricity consumption in the Eastern Denmark. The macros are installed at Elkraft, Ballerup.......SAS-macros for estimation and prediction in an model of the electricity consumption'' is a large collection of SAS-macros for handling a model of the electricity consumption in the Eastern Denmark. The macros are installed at Elkraft, Ballerup....

  3. A Tool that Uses the SAS (registered trademark) PRX Functions to Fix Delimited Text Files

    Science.gov (United States)

    2015-07-07

    Article 3. DATES COVERED (From – To) Dec 2014 – Apr 2015 4. TITLE AND SUBTITLE A Tool that Uses the SAS® PRX Functions to Fix Delimited Text Files 5a...Guide® project that uses the SAS PRX functions to import, fix, and export a delimited text file. This fixed file can then be easily imported and...sas, perl, prx , prx functions, sas enterprise guide, sas eg, prxmatch, prxchange 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT SAR

  4. The SAS Education Value-Added Assessment System (SAS[R] EVAAS[R]) in the Houston Independent School District (HISD): Intended and Unintended Consequences

    Science.gov (United States)

    Amrein-Beardsley, Audrey; Collins, Clarin

    2012-01-01

    The SAS Educational Value-Added Assessment System (SAS[R] EVAAS[R]) is the most widely used value-added system in the country. It is also self-proclaimed as "the most robust and reliable" system available, with its greatest benefit to help educators improve their teaching practices. This study critically examined the effects of SAS[R] EVAAS[R] as…

  5. 面向对象的SAS/AF程序设计语言的研究%Research on Object-Oriented Programming with SAS/AF Language

    Institute of Scientific and Technical Information of China (English)

    陈宇术

    2001-01-01

    This paper aims at introducing object-oriented program language using SAS/AF with the concepts of OOA and OOD.And it also discusses how to achieve these concepts in SAS/AF language.%本文结合面向对象分析(OOA)与面向对象设计(OOD)介绍了面向对象的SAS/AF程序语言及探讨了面向对象的理念在SAS/AF中的实现。

  6. Olev Schults : SAS vajab Estonian Airi rahvusliku lennufirmana / Olev Schults ; interv. Andres Reimer

    Index Scriptorium Estoniae

    Schults, Olev

    2008-01-01

    Estonian Airi nõukogu esimees vastab küsimustele, kas SAS arendas Läti airBalticut Estonian SAS-i arvel, mis mõte on rahvuslikul lennukompaniil, kui riik ei tohi seda finantseerida, kuidas mõjutab investorite meeleolu SAS-i Eestis tabanud poliitikute kriitika tulv

  7. %HPGLIMMIX: A High-Performance SAS Macro for GLMM Estimation

    Directory of Open Access Journals (Sweden)

    Liang Xie

    2014-06-01

    Full Text Available Generalized linear mixed models (GLMMs comprise a class of widely used statistical tools for data analysis with fixed and random effects when the response variable has a conditional distribution in the exponential family. GLMM analysis also has a close relationship with actuarial credibility theory. While readily available programs such as the GLIMMIX procedure in SAS and the lme4 package in R are powerful tools for using this class of models, these progarms are not able to handle models with thousands of levels of fixed and random effects. By using sparse-matrix and other high performance techniques, procedures such as HPMIXED in SAS can easily fit models with thousands of factor levels, but only for normally distributed response variables. In this paper, we present the %HPGLIMMIX SAS macro that fits GLMMs with large number of sparsely populated design matrices using the doubly-iterative linearization (pseudo-likelihood method, in which the sparse-matrix-based HPMIXED is used for the inner iterations with the pseudo-variable constructed from the inverse-link function and the chosen model. Although the macro does not have the full functionality of the GLIMMIX procedure, time and memory savings can be large with the new macro. In applications in which design matrices contain many zeros and there are hundreds or thousands of factor levels, models can be fitted without exhausting computer memory, and 90% or better reduction in running time can be observed. Examples with a Poisson, binomial, and gamma conditional distribution are presented to demonstrate the usage and efficiency of this macro.

  8. SAS 3 survey of the soft X-ray background

    Science.gov (United States)

    Marshall, F. J.; Clark, G. W.

    1984-01-01

    The results of a survey of the soft X-ray sky in the C band (0.10-0.28keV) are reported. The observations were carried out using two independent flow proportional counters on board the SAS 3 X-ray satellite which had a total angular resolution of 2.9 deg FWHM, and a total exposure of 2.2 x 10 to the 4th per sq cm s sr. It is found that C band counting rates were generally inversely correlated with the column density of the neutral hydrogen on all angular scales down to the lowest angular resolution of the detectors. In the region 90-180 deg l and 0-10 deg b, the relation between C-band rates and the column densities of neutral hydrogen was fitted with a residual rms deviation of less than 13 percent by a two-component numerical model of the X-ray background. For the apparent attenuation column density a value of 2.7 x 10 to the 20th per sq cm was obtained. On the basis of a computer simulation of the SAS 3 data, it is shown that the observed clumping of interstellar matter was consistent with the magnitude of spatial fluctuations in the C-band map. When the background rates were subtracted from the survey map, the subsequent map showed foreground emission and absorption features with improved sensitivity and clarity. A series of computer-generated maps incorporating the SAS 3 data is given in an appendix.

  9. Categorical Data Analysis With Sas and Spss Applications

    CERN Document Server

    Lawal, H Bayo

    2003-01-01

    This book covers the fundamental aspects of categorical data analysis with an emphasis on how to implement the models used in the book using SAS and SPSS. This is accomplished through the frequent use of examples, with relevant codes and instructions, that are closely related to the problems in the text. Concepts are explained in detail so that students can reproduce similar results on their own. Beginning with chapter two, exercises at the end of each chapter further strengthen students' understanding of the concepts by requiring them to apply some of the ideas expressed in the text in a more

  10. Identify S.A.S. -Plan de empresa

    OpenAIRE

    2012-01-01

    IDENTIFY S.A.S. – Soluciones en Tecnología, tiene como objetivos desarrollar un plan de empresa para suplir una de las necesidades, que en la actualidad cobra importancia en los centros hospitalarios y que contribuye al control y detección automática de personas y activos y control de temperatura enn activos dedicados al almacenamiento de medicamentos e insumos, permitiendo el manejo de la información en tiempo real; teniendo presente la normatividad que las rige, la seguridad que les propor...

  11. Plan de empresa SZ Gastroconsulting S.A.S.

    OpenAIRE

    Zuloaga Galofre, David; Serrano Zuleta, Juanita

    2015-01-01

    SZ GastroConsulting S.A.S. es una empresa colombiana que prestará servicios de consultoría al sector de restaurantes. El core del negocio estará orientado a incrementar la rotación de clientes y la facturación de los restaurantes. De forma complementaria, se adoptarán prácticas tecnológicas, aprovechando el entorno actual donde los comensales inician su experiencia de consumo antes de ir al restaurante, y la finalizan días después de vivirla. La compañía será dirigida por los socios y consult...

  12. Plan de Negocios Qualitas S.A.S.

    OpenAIRE

    Verutti Bonilla, María Cecilia; Ávila González, Gloria Inés; Ortiz Alvarado, Francisco Javier

    2012-01-01

    Qualitas S.A.S. Health & Consulting (del latín: “calidad”), nace un equipo multidisciplinario de profesionales de crear una empresa de consultoría especializada en salud en Popayán, como apoyo a los Prestadores de Servicios de Salud, en aspectos relacionados con los requisitos que deben cumplir ante las normas del Sistema Obligatorio de Garantía de la Calidad en Salud que reglamentan la atención de calidad en los servicios de salud en Colombia, teniendo como meta la excelencia. Objetivos: R...

  13. Polymer encapsulation of amoxicillin microparticles by SAS process.

    Science.gov (United States)

    Montes, A; Baldauf, E; Gordillo, M D; Pereyra, C M; Martínez de la Ossa, E J

    2014-01-01

    Encapsulation of amoxicillin (AMC) with ethyl cellulose (EC) by a supercritical antisolvent process (SAS) was investigated. AMC microparticles obtained previously by an SAS process were used as host particles and EC, a biodegradable polymer used for the controlled release of drugs, was chosen as the coating material. In this work, a suspension of AMC microparticles in a solution of ethyl cellulose in dichloromethane (DCM) was sprayed through a nozzle into supercritical CO2. Scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) and HPLC analyses were carried out. The effects of AMC:EC ratio, the initial polymer concentration of the solution, temperature and pressure on the encapsulation process were investigated. Although all the experiments led to powder precipitation, the AMC encapsulation was achieved in only half of the cases, particularly when the lower drug:polymer ratios were assayed. In general, it was observed that the percentages of AMC present in the precipitates were higher on increasing the AMC:EC ratio. In these cases composites rather than encapsulates were obtained. The in vitro release profiles of the resulting materials were evaluated in order to ascertain whether composites can be used as encapsulated systems for drug delivery systems.

  14. Recent high energy gamma-ray results from SAS-2

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Hartman, R. C.; Kniffen, D. A.; Bignami, G. F.; Ogelman, H. B.; Ozel, M. E.; Tumer, T.; Lamb, R. C.

    1977-01-01

    Recent developments in gamma-ray astronomy due to the results from SAS-2 have focused on two areas. First, the emission from the plane of the Galaxy is the dominant feature in the gamma-ray sky. The galactic latitude and longitude distributions are consistent with the concept that the high-energy radiation originates from cosmic rays interacting with interstellar matter, and the measurements support a galactic origin for cosmic rays. Second, searches of the SAS-2 data for emission from localized sources have shown three strong discrete gamma-ray sources: the Crab nebula and PSR 0531 + 21, the Vela supernova remnant and PSR 0833-45, and a source near galactic coordinates 193 deg longitude, +3 deg latitude, which does not appear to be associated with other known celestial objects. Evidence has also been found for pulsed gamma-ray emission from two other radio pulsars, PSR 1818-04 and PSR 1747-46. A localized source near longitudes 76-80 deg may be associated with the X-ray source Cyg X-3.

  15. The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation.

    Science.gov (United States)

    Rogala, Kacper B; Dynes, Nicola J; Hatzopoulos, Georgios N; Yan, Jun; Pong, Sheng Kai; Robinson, Carol V; Deane, Charlotte M; Gönczy, Pierre; Vakonakis, Ioannis

    2015-05-29

    Centrioles are microtubule-based organelles crucial for cell division, sensing and motility. In Caenorhabditis elegans, the onset of centriole formation requires notably the proteins SAS-5 and SAS-6, which have functional equivalents across eukaryotic evolution. Whereas the molecular architecture of SAS-6 and its role in initiating centriole formation are well understood, the mechanisms by which SAS-5 and its relatives function is unclear. Here, we combine biophysical and structural analysis to uncover the architecture of SAS-5 and examine its functional implications in vivo. Our work reveals that two distinct self-associating domains are necessary to form higher-order oligomers of SAS-5: a trimeric coiled coil and a novel globular dimeric Implico domain. Disruption of either domain leads to centriole duplication failure in worm embryos, indicating that large SAS-5 assemblies are necessary for function in vivo.

  16. SPSS and SAS programs for generalizability theory analyses.

    Science.gov (United States)

    Mushquash, Christopher; O'Connor, Brian P

    2006-08-01

    The identification and reduction of measurement errors is a major challenge in psychological testing. Most investigators rely solely on classical test theory for assessing reliability, whereas most experts have long recommended using generalizability theory instead. One reason for the common neglect of generalizability theory is the absence of analytic facilities for this purpose in popular statistical software packages. This article provides a brief introduction to generalizability theory, describes easy to use SPSS, SAS, and MATLAB programs for conducting the recommended analyses, and provides an illustrative example, using data (N = 329) for the Rosenberg Self-Esteem Scale. Program output includes variance components, relative and absolute errors and generalizability coefficients, coefficients for D studies, and graphs of D study results.

  17. Modeling binary correlated responses using SAS, SPSS and R

    CERN Document Server

    Wilson, Jeffrey R

    2015-01-01

    Statistical tools to analyze correlated binary data are spread out in the existing literature. This book makes these tools accessible to practitioners in a single volume. Chapters cover recently developed statistical tools and statistical packages that are tailored to analyzing correlated binary data. The authors showcase both traditional and new methods for application to health-related research. Data and computer programs will be publicly available in order for readers to replicate model development, but learning a new statistical language is not necessary with this book. The inclusion of code for R, SAS, and SPSS allows for easy implementation by readers. For readers interested in learning more about the languages, though, there are short tutorials in the appendix. Accompanying data sets are available for download through the book s website. Data analysis presented in each chapter will provide step-by-step instructions so these new methods can be readily applied to projects.  Researchers and graduate stu...

  18. Non-linear Growth Models in Mplus and SAS.

    Science.gov (United States)

    Grimm, Kevin J; Ram, Nilam

    2009-10-01

    Non-linear growth curves or growth curves that follow a specified non-linear function in time enable researchers to model complex developmental patterns with parameters that are easily interpretable. In this paper we describe how a variety of sigmoid curves can be fit using the Mplus structural modeling program and the non-linear mixed-effects modeling procedure NLMIXED in SAS. Using longitudinal achievement data collected as part of a study examining the effects of preschool instruction on academic gain we illustrate the procedures for fitting growth models of logistic, Gompertz, and Richards functions. Brief notes regarding the practical benefits, limitations, and choices faced in the fitting and estimation of such models are included.

  19. %ERA: A SAS Macro for Extended Redundancy Analysis

    Directory of Open Access Journals (Sweden)

    Pietro Giorgio Lovaglio

    2016-10-01

    Full Text Available A new approach to structural equation modeling based on so-called extended redundancy analysis has been recently proposed in the literature, enhanced with the added characteristic of generalizing redundancy analysis and reduced-rank regression models for more than two blocks. In this approach, the relationships between the observed exogenous variables and the observed endogenous variables are moderated by the presence of unobservable composites that were estimated as linear combinations of exogenous variables, permitting a great flexibility to specify and fit a variety of structural relationships. In this paper, we propose the SAS macro %ERA to specify and fit structural relationships in the extended redundancy analysis (ERA framework. Two examples (simulation and real data are provided in order to reproduce results appearing in the original article where ERA was proposed.

  20. SAS-2 galactic gamma ray results. 2. Localized sources

    Science.gov (United States)

    Hartman, R. C.; Fichtel, C. E.; Kniffen, D. A.; Lamb, R. C.; Thompson, D. J.; Bignami, G. F.; Oegelman, H.; Oezel, M. E.; Tuemer, T.

    1976-01-01

    Gamma-ray emission was detected from the radio pulsars PSR1818-04 and PSR1747-46, in addition to the previously reported gamma-ray emission from the Crab and Vela pulsars. Since the Crab pulsar is the only one observed in the optical and X-ray bands, these gamma-ray observations suggest a uniquely gamma-ray phenomenon occurring in a fraction of the radio pulsars. Using distance estimates it is found that PSR1818-04 has a gamma-ray luminosity comparable to that of the Crab pulsar, while the luminosities of PSR1747-46 and the Vela pulsar are approximately an order of magnitude lower. This survey of SAS-2 data for pulsar correlations has also yielded upper limits to gamma-ray luminosity for 71 other radio pulsars.

  1. Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth.

    Science.gov (United States)

    Sharma, Ashwani; Aher, Amol; Dynes, Nicola J; Frey, Daniel; Katrukha, Eugene A; Jaussi, Rolf; Grigoriev, Ilya; Croisier, Marie; Kammerer, Richard A; Akhmanova, Anna; Gönczy, Pierre; Steinmetz, Michel O

    2016-05-23

    Centrioles are fundamental and evolutionarily conserved microtubule-based organelles whose assembly is characterized by microtubule growth rates that are orders of magnitude slower than those of cytoplasmic microtubules. Several centriolar proteins can interact with tubulin or microtubules, but how they ensure the exceptionally slow growth of centriolar microtubules has remained mysterious. Here, we bring together crystallographic, biophysical, and reconstitution assays to demonstrate that the human centriolar protein CPAP (SAS-4 in worms and flies) binds and "caps" microtubule plus ends by associating with a site of β-tubulin engaged in longitudinal tubulin-tubulin interactions. Strikingly, we uncover that CPAP activity dampens microtubule growth and stabilizes microtubules by inhibiting catastrophes and promoting rescues. We further establish that the capping function of CPAP is important to limit growth of centriolar microtubules in cells. Our results suggest that CPAP acts as a molecular lid that ensures slow assembly of centriolar microtubules and, thereby, contributes to organelle length control.

  2. SAS program for quantitative stratigraphic correlation by principal components

    Science.gov (United States)

    Hohn, M.E.

    1985-01-01

    A SAS program is presented which constructs a composite section of stratigraphic events through principal components analysis. The variables in the analysis are stratigraphic sections and the observational units are range limits of taxa. The program standardizes data in each section, extracts eigenvectors, estimates missing range limits, and computes the composite section from scores of events on the first principal component. Provided is an option of several types of diagnostic plots; these help one to determine conservative range limits or unrealistic estimates of missing values. Inspection of the graphs and eigenvalues allow one to evaluate goodness of fit between the composite and measured data. The program is extended easily to the creation of a rank-order composite. ?? 1985.

  3. Comparative M-H Characteristics of 1-5 and 2-17 Type Samarium-Cobalt Permanent Magnets to 300 C

    Science.gov (United States)

    Niedra, Janis M.

    1994-01-01

    Recent consideration of the use of permanent magnets in space power converters at heat rejection temperatures exceeding 250 C and in miniature high temperature actuators is supporting a search for permanent magnets resistant to demagnetizing forces at high temperature. The present paper investigates the short-term demagnetization resistance to applied bucking fields and at temperatures up to 300 C of SmCo5 type magnets, in the form of 1-cm cubes, from several commercial sources. Quasistatic, 2nd quadrant M-H data taken at selected temperatures are the source of derived plots which are then compared to similar data for previously tested Sm2Co17 type magnets. The 1-5 magnet remanence tends to be about 1.5 kG below that of the 2-17 magnets throughout the temperature range. However, the intrinsic coercivities and M-H curve 'knee-fields' seen in particular 1-5 magnets were considerably above those seen previously in the 2-17 magnets. This superior resistance to demagnetizing fields attainable in 1-5 magnets is also illustrated by safe operating area plots based on the knee-field, the magnetic induction swing and temperature. Comments are made on the possibility that a remanence versus knee-field tradeoff can make 1-5 material competitive with 2-17 in applications where a magnet has to withstand large bucking fields at high temperature.

  4. Research and development of KYRY YT300C HF electrosurgical unit%KYKY YT300C高频电刀的研制开发

    Institute of Scientific and Technical Information of China (English)

    田艳军; 武剑; 廖春林

    2000-01-01

    研制成功的KYKY YT300C高频电刀主要由高频电压输出部分、功率测量部分和安全检测部分组成。采用了先进的PWM、双CPU技术,用大功率VMOS场效应管作为功率器件,功耗小能量转换效率高,RF输出功率稳定,具有很好的切凝效果。%This paper introduces the KYRY YT300C electrosurgical unit composed of three parts of HF voltage output, power measurement and security examination. With the application of high-power VMOS FET as the power component and advanced technologies including PWM and Bi-CPU, it has low wasted work, high efficiency of energy transition, constant power of RF output and good effect of incision and coagulation. It has been proven by experiment that it is comparable with advanced foreign one.

  5. Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos.

    Science.gov (United States)

    Kitagawa, Daiju; Busso, Coralie; Flückiger, Isabelle; Gönczy, Pierre

    2009-12-01

    Despite being essential for proper cell division, the mechanisms governing centrosome duplication are incompletely understood and represent an important open question in cell biology. Formation of a new centriole next to each existing one is critical for centrosome duplication. In Caenorhabditis elegans embryos, the proteins SPD-2, ZYG-1, SAS-6, SAS-5, and SAS-4 are essential for centriole formation, but the mechanisms underlying their requirement remain unclear. Here, we demonstrate that the kinase ZYG-1 phosphorylates the coiled-coil protein SAS-6 at serine 123 in vitro. Importantly, we show that this phosphorylation event is crucial for centriole formation in vivo. Furthermore, we establish that such phosphorylation ensures the maintenance of SAS-6 at the emerging centriole. Overall, our findings establish that phosphorylation of the evolutionarily conserved protein SAS-6 is critical for centriole formation and thus for faithful cell division.

  6. LSI推出首批半高SAS RAID适配器

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    LSI Logic公司近日宣布推出首批半高(low—profile,LP)SAS RAID存储适配器。新的MegaRAID SAS 8308ELP和SAS8344ELP是具有8个SAS端口的PCI Express接口适配器,应用于需要使用3GbpsSAS和/或SATAⅡ驱动器的服务器和工作站环境。

  7. Validity of Simpson-Angus Scale (SAS in a naturalistic schizophrenia population

    Directory of Open Access Journals (Sweden)

    Tuisku Katinka

    2005-03-01

    Full Text Available Abstract Background Simpson-Angus Scale (SAS is an established instrument for neuroleptic-induced parkinsonism (NIP, but its statistical properties have been studied insufficiently. Some shortcomings concerning its content have been suggested as well. According to a recent report, the widely used SAS mean score cut-off value 0.3 of for NIP detection may be too low. Our aim was to evaluate SAS against DSM-IV diagnostic criteria for NIP and objective motor assessment (actometry. Methods Ninety-nine chronic institutionalised schizophrenia patients were evaluated during the same interview by standardised actometric recording and SAS. The diagnosis of NIP was based on DSM-IV criteria. Internal consistency measured by Cronbach's α, convergence to actometry and the capacity for NIP case detection were assessed. Results Cronbach's α for the scale was 0.79. SAS discriminated between DSM-IV NIP and non-NIP patients. The actometric findings did not correlate with SAS. ROC-analysis yielded a good case detection power for SAS mean score. The optimal threshold value of SAS mean score was between 0.65 and 0.95, i.e. clearly higher than previously suggested threshold value. Conclusion We conclude that SAS seems a reliable and valid instrument. The previously commonly used cut-off mean score of 0.3 has been too low resulting in low specificity, and we suggest a new cut-off value of 0.65, whereby specificity could be doubled without loosing sensitivity.

  8. 关于SAS-Weblogic的数据挖掘模型的应用分析

    Institute of Scientific and Technical Information of China (English)

    周清松

    2015-01-01

    本文在对SAS-Weblogic的数据挖掘模型和应用进行应用分析时,首先分析了SAS-Weblogic的数据挖掘模型,最后基于实例分析了SAS-Weblogic的数据挖掘模型的具体应用。SAS-Weblogic数据挖掘模型不仅仅解决了一般数据量的设计要求,结合ARIMA模型同样对于大数据量的设计要求也能得到有效的解决。

  9. Observations of low energy gamma-ray bursts with SAS-2

    Science.gov (United States)

    Oegelman, H.; Fichtel, C. E.; Kniffen, D. A.

    1975-01-01

    The present paper reports on the low-energy gamma-ray bursts observed by the plastic scintillator anticoincidence dome of the Small Astronomy Satellite-2 (SAS-2) gamma-ray telescope. SAS-2 detected two events observed by other satellites and discovered one which was subsequently confirmed by other satellite observations. Two events seen by other satellites were not detected by SAS-2, probably due to earth occultation. The event detection threshold for SAS-2 was almost two orders of magnitude lower than that of the Vela satellites.

  10. A SAS/IML program using the Kalman filter for estimating state space models.

    Science.gov (United States)

    Gu, Fei; Yung, Yiu-Fai

    2013-03-01

    To help disseminate the knowledge and software implementation of a state space model (SSM), this article provides a SAS/IML (SAS Institute, 2010) program for estimating the parameters of general linear Gaussian SSMs using the Kalman filter algorithm. In order to use this program, the user should have SAS installed on a computer and have a valid license for SAS/IML. Since the code is completely open, it is expected that this program can be used not only by applied researchers, but also by quantitative methodologists who are interested in improving their methods and promoting SSM as a research instrument.

  11. PP2A phosphatase acts upon SAS-5 to ensure centriole formation in C. elegans embryos.

    Science.gov (United States)

    Kitagawa, Daiju; Flückiger, Isabelle; Polanowska, Jolanta; Keller, Debora; Reboul, Jérôme; Gönczy, Pierre

    2011-04-19

    Centrosome duplication occurs once per cell cycle and ensures that the two resulting centrosomes assemble a bipolar mitotic spindle. Centriole formation is fundamental for centrosome duplication. In Caenorhabditis elegans, the evolutionarily conserved proteins SPD-2, ZYG-1, SAS-6, SAS-5, and SAS-4 are essential for centriole formation, but how they function is not fully understood. Here, we demonstrate that Protein Phosphatase 2A (PP2A) is also critical for centriole formation in C. elegans embryos. We find that PP2A subunits genetically and physically interact with the SAS-5/SAS-6 complex. Furthermore, we show that PP2A-mediated dephosphorylation promotes centriolar targeting of SAS-5 and ensures SAS-6 delivery to the site of centriole assembly. We find that PP2A is similarly needed for the presence of HsSAS-6 at centrioles and for centriole formation in human cells. These findings lead us to propose that PP2A-mediated loading of SAS-6 proteins is critical at the onset of centriole formation.

  12. SAS molecular tests Salmonella detection kit. Performance tested method 021202.

    Science.gov (United States)

    Bapanpally, Chandra; Montier, Laura; Khan, Shah; Kasra, Akif; Brunelle, Sharon L

    2014-01-01

    The SAS Molecular tests Salmonella Detection method, a Loop-mediated Isothermal Amplification method, performed as well as or better than the U.S. Department of Agriculture-Food Safety Inspection Service Microbiology Laboratory Guidebook and the U.S. Food and Drug Administration Bacteriological Analytical Manual reference methods for ground beef, beef trim, ground turkey, chicken carcass rinses, bagged mixed lettuce, and fresh spinach. The ground beef (30% fat, 25 g test portion), poultry matrixes and leafy greens were validated in a 6-7 h enrichment, and ground beef (30% fat, 375 g composite test portion) and beef trim (375 g composite test portion) were validated in a 16-20 h enrichment. The method performance for meat and leafy green matrixes was shown to be acceptable under conditions of co-enrichment with Escherichia coli 0157. Thus, after a short 6-7 h co-enrichment step, ground beef, beef trim, lettuce, and spinach can be tested for both Salmonella and E. coli O157. Inclusivity and exclusivity testing revealed no false negatives and no false positives among the 100 Salmonella serovars and 30 non-Salmonella species examined. The method was shown to be robust when enrichment time, DNA extract hold time, and DNA volume were varied.

  13. Circinus X-1 - X-ray observations with SAS 3

    Science.gov (United States)

    Dower, R. G.; Bradt, H. V.; Morgan, E. H.

    1982-01-01

    Eight observations of Cir X-1 with SAS 3, each lasting 1-6 days, have yielded a variety of new phenomena, viz., a luminous state of steady emission, rapid large-intensity dips, an extremely rapid X-ray transition, and bright flares. Through searches for periodic X-ray pulsations were carried out on data trains of duration up to 6 days; upper limits for pulsations with periods greater than 250 microsec range down to 0.3%. Aperiodic variability with characteristic times of 0.4-1.0 sec was observed but is not well characterized by a simple shot noise model. No millisecond bursts were observed during 40,000 sec in three separate observations. Spectral parameters derived before and after several X-ray transitions indicate that the transitions are not due to absorption of X-rays by intervening gas. Models previously proposed for the Cir X-1 system do not easily provide explanations for all the complex phenomena reported herein.

  14. SAS-2 galactic gamma-ray results. 2: Localized sources

    Science.gov (United States)

    Hartman, R. C.; Fichtel, C. E.; Kniffen, D. A.; Lamb, R. C.; Thompson, D. J.; Bignami, G. F.; Oegelman, H.; Oezel, M. E.; Tuemer, T.

    1977-01-01

    Gamma ray emission was detected from the radio pulsars PSR 1818-04 and PSR 1747-46, in addition to the previously reported gamma ray emission from the Crab and Vela pulsars. Because the Crab pulsar is the only one observed in the optical and X-ray bands, these gamma ray observations suggest a uniquely gamma ray phenomenon occurring in a fraction of the radio pulsars. PSR 1818-04 has a gamma ray luminosity comparable to that of the Crab pulsar, whereas the luminosities of PSR 1747-46 and the Vela pulsar are approximately an order of magnitude lower. SAS-2 data for pulsar correlations yielded upper limits to gamma ray luminosity for 71 other radio pulsars. For five of the closest pulsars, upper limits for gamma ray luminosity are found to be at least three orders of magnitude lower than that of the Crab pulsar. Gamma ray enhancement near the Milky Way satellite galaxy and the galactic plane in the Cygnus region is also discussed.

  15. Using SAS/IntrNet for Evaluating Web-Based Courses.

    Science.gov (United States)

    Yu, Chong-ho; Jannasch-Pennell, Angel; Digangi, Sam; Wasson, Barnaby

    1998-01-01

    Describes the use of SAS/IntrNet, a Web service rather than a Web server, to evaluate and enhance university level Web-based courses. IntrNet provides the ability to create both static and dynamic Web pages, using Web publishing tools to convert SAS output to hypertext markup language for the creation of static Web pages. (Author/LRW)

  16. Using SAS/IntrNet for Evaluating Web-Based Courses.

    Science.gov (United States)

    Yu, Chong-ho; Jannasch-Pennell, Angel; Digangi, Sam; Wasson, Barnaby

    1998-01-01

    Describes the use of SAS/IntrNet, a Web service rather than a Web server, to evaluate and enhance university level Web-based courses. IntrNet provides the ability to create both static and dynamic Web pages, using Web publishing tools to convert SAS output to hypertext markup language for the creation of static Web pages. (Author/LRW)

  17. SAS üritab panna riiki lennufirma aktsiaid müüma / Lemmi Kann

    Index Scriptorium Estoniae

    Kann, Lemmi

    2007-01-01

    SAS-i eesmärgiks on saada enamusosalus nii Estonian Airis kui ka airBalticus, et seeläbi oma positsioone Baltimaades kinnistada. Diagramm: Estonian Airi majandusnäitajad ja omanikud. Vt. samas: SAS on Estonian Airi jahtinud kaua. Kommenteerib Raivo Vare

  18. SAS tahab Estonian Airi liita lätlaste firmaga airBaltic / Andres Eilart

    Index Scriptorium Estoniae

    Eilart, Andres

    2007-01-01

    SAS plaanib Estonian Airi ja Läti firma airBalticu liitmisega luua uue lennufirma. Autori hinnangul viitavad Estonian Airi laienemisplaanidele kriipsu peale tõmbamine ja SAS-i investeeringud airBalticusse sellele, et ühendamise käigus "neelab" Läti firma Estonian Airi

  19. Social Anxiety Scale for Adolescents (SAS-A): Measuring Social Anxiety among Finnish Adolescents

    Science.gov (United States)

    Ranta, Klaus; Junttila, Niina; Laakkonen, Eero; Uhmavaara, Anni; La Greca, Annette M.; Niemi, Paivi M.

    2012-01-01

    The aim of this study was to investigate symptoms of social anxiety and the psychometric properties of the "Social Anxiety Scale for Adolescents" (SAS-A) among Finnish adolescents, 13-16 years of age. Study 1 (n = 867) examined the distribution of SAS-A scores according to gender and age, and the internal consistency and factor structure…

  20. [Standardization of the Greek version of Zung's Self-rating Anxiety Scale (SAS)].

    Science.gov (United States)

    Samakouri, M; Bouhos, G; Kadoglou, M; Giantzelidou, A; Tsolaki, K; Livaditis, M

    2012-01-01

    Self-rating Anxiety Scale (SAS), introduced by Zung, has been widely used in research and in clinical practice for the detection of anxiety. The present study aims at standardizing the Greek version of SAS. SAS consists of 20 items rated on a 1-4 likert type scale. The total SAS score may vary from 20 (no anxiety at all) to 80 (severe anxiety). Two hundred and fifty four participants (114 male and 140 female), psychiatric patients, physically ill and general population individuals, aged 45.40±11.35 years, completed the following: (a) a demographic characteristics' questionnaire, (b) the SAS Greek version, (c) the Spielberg's Modified Greek State-Trait Anxiety Scale (STAI-Gr.-X) and (d) the Zung Depression Rating Scale (ZDRS). Seventy six participants answered the SAS twice within a 12th-day median period of time. The following parameters were calculated: (a) internal consistency of the SAS in terms of Cronbach's α co-efficient, (b) its test-retest reliability in terms of the Intraclass Correlation Coefficient (ICC) and (c) its concurrent and convergent validities through its score's Spearman's rho correlations with both the state and trait subscales of STAI-Gr X and the ZDRS. In addition, in order to evaluate SAS' discriminant validity, the scale's scores of the three groups of participants (psychiatric patients, physically ill and general population individuals) were compared among each other, in terms of Kruskall Wallis and Mann Whitney U tests. SAS Cronbach's alpha equals 0.897 while ICC regarding its test-retest reliability equals 0.913. Spearman's rho concerning validity: (a) when SAS is compared to STAI-Gr.-X (state), equals it 0.767, (b) when SAS is compared to STAI-Gr. X (trait), it equals 0.802 and (c) when SAS is compared to ZDRS, it equals 0.835. The mentally ill scored significantly higher in SAS compared to both the healthy and the general population. In conclusion, the SAS Greek version presents very satisfactory psychometric properties regarding

  1. SAS-1 is a C2 domain protein critical for centriole integrity in C. elegans.

    Science.gov (United States)

    von Tobel, Lukas; Mikeladze-Dvali, Tamara; Delattre, Marie; Balestra, Fernando R; Blanchoud, Simon; Finger, Susanne; Knott, Graham; Müller-Reichert, Thomas; Gönczy, Pierre

    2014-11-01

    Centrioles are microtubule-based organelles important for the formation of cilia, flagella and centrosomes. Despite progress in understanding the underlying assembly mechanisms, how centriole integrity is ensured is incompletely understood, including in sperm cells, where such integrity is particularly critical. We identified C. elegans sas-1 in a genetic screen as a locus required for bipolar spindle assembly in the early embryo. Our analysis reveals that sperm-derived sas-1 mutant centrioles lose their integrity shortly after fertilization, and that a related defect occurs when maternal sas-1 function is lacking. We establish that sas-1 encodes a C2 domain containing protein that localizes to centrioles in C. elegans, and which can bind and stabilize microtubules when expressed in human cells. Moreover, we uncover that SAS-1 is related to C2CD3, a protein required for complete centriole formation in human cells and affected in a type of oral-facial-digital (OFD) syndrome.

  2. SAS-1 is a C2 domain protein critical for centriole integrity in C. elegans.

    Directory of Open Access Journals (Sweden)

    Lukas von Tobel

    2014-11-01

    Full Text Available Centrioles are microtubule-based organelles important for the formation of cilia, flagella and centrosomes. Despite progress in understanding the underlying assembly mechanisms, how centriole integrity is ensured is incompletely understood, including in sperm cells, where such integrity is particularly critical. We identified C. elegans sas-1 in a genetic screen as a locus required for bipolar spindle assembly in the early embryo. Our analysis reveals that sperm-derived sas-1 mutant centrioles lose their integrity shortly after fertilization, and that a related defect occurs when maternal sas-1 function is lacking. We establish that sas-1 encodes a C2 domain containing protein that localizes to centrioles in C. elegans, and which can bind and stabilize microtubules when expressed in human cells. Moreover, we uncover that SAS-1 is related to C2CD3, a protein required for complete centriole formation in human cells and affected in a type of oral-facial-digital (OFD syndrome.

  3. First report of sasX-positive methicillin-resistant Staphylococcus aureus in Japan.

    Science.gov (United States)

    Nakaminami, Hidemasa; Ito, Teruyo; Han, Xiao; Ito, Ayumu; Matsuo, Miki; Uehara, Yuki; Baba, Tadashi; Hiramatsu, Keiichi; Noguchi, Norihisa

    2017-09-01

    SasX is a known virulence factor of Staphylococcus aureus involved in colonisation and immune evasion of the bacterium. The sasX gene, which is located on the ϕSPβ prophage, is frequently found in the sequence type (ST) 239 S. aureus lineage, which is the predominant healthcare-associated clone in Asian countries. In Japan, ST239 clones have rarely been identified, and sasX-positive strains have not been reported to date. Here, we report the first identification of 18 sasX-positive methicillin-resistant S. aureus (MRSA) strains in Japanese hospitals between 2009 and 2011. All sasX-positive isolates belonged to an ST239-staphylococcal cassette chromosome mec type III (ST239-III) lineage. However, we were unable to identify additional sasX-positive MRSA strains from 2012 to 2016, indicating that the small epidemic of sasX-positive isolates observed in this study was temporary. The sequence surrounding sasX in the strain TOHH628 lacked 51 genes that encode phage packaging and structural proteins, and no bacteriophage was induced by mitomycin C. Additionally, in the TOHH628 strain, the region (64.6 kb) containing sasX showed high identity to the ϕSPβ-like element (71.3 kb) of the Taiwanese MRSA strain Z172. The data strongly suggest that the present sasX-positive isolates found in Japanese hospitals were transmitted incidentally from other countries. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  4. Zinc-dependent mechanical properties of Staphylococcus aureus biofilm-forming surface protein SasG.

    Science.gov (United States)

    Formosa-Dague, Cécile; Speziale, Pietro; Foster, Timothy J; Geoghegan, Joan A; Dufrêne, Yves F

    2016-01-12

    Staphylococcus aureus surface protein SasG promotes cell-cell adhesion during the accumulation phase of biofilm formation, but the molecular basis of this interaction remains poorly understood. Here, we unravel the mechanical properties of SasG on the surface of living bacteria, that is, in its native cellular environment. Nanoscale multiparametric imaging of living bacteria reveals that Zn(2+) strongly increases cell wall rigidity and activates the adhesive function of SasG. Single-cell force measurements show that SasG mediates cell-cell adhesion via specific Zn(2+)-dependent homophilic bonds between β-sheet-rich G5-E domains on neighboring cells. The force required to unfold individual domains is remarkably strong, up to ∼500 pN, thus explaining how SasG can withstand physiological shear forces. We also observe that SasG forms homophilic bonds with the structurally related accumulation-associated protein of Staphylococcus epidermidis, suggesting the possibility of multispecies biofilms during host colonization and infection. Collectively, our findings support a model in which zinc plays a dual role in activating cell-cell adhesion: adsorption of zinc ions to the bacterial cell surface increases cell wall cohesion and favors the projection of elongated SasG proteins away from the cell surface, thereby enabling zinc-dependent homophilic bonds between opposing cells. This work demonstrates an unexpected relationship between mechanics and adhesion in a staphylococcal surface protein, which may represent a general mechanism among bacterial pathogens for activating cell association.

  5. SAS-6 assembly templated by the lumen of cartwheel-less centrioles precedes centriole duplication.

    Science.gov (United States)

    Fong, Chii Shyang; Kim, Minhee; Yang, T Tony; Liao, Jung-Chi; Tsou, Meng-Fu Bryan

    2014-07-28

    Centrioles are 9-fold symmetric structures duplicating once per cell cycle. Duplication involves self-oligomerization of the centriolar protein SAS-6, but how the 9-fold symmetry is invariantly established remains unclear. Here, we found that SAS-6 assembly can be shaped by preexisting (or mother) centrioles. During S phase, SAS-6 molecules are first recruited to the proximal lumen of the mother centriole, adopting a cartwheel-like organization through interactions with the luminal wall, rather than via their self-oligomerization activity. The removal or release of luminal SAS-6 requires Plk4 and the cartwheel protein STIL. Abolishing either the recruitment or the removal of luminal SAS-6 hinders SAS-6 (or centriole) assembly at the outside wall of mother centrioles. After duplication, the lumen of engaged mother centrioles becomes inaccessible to SAS-6, correlating with a block for reduplication. These results lead to a proposed model that centrioles may duplicate via a template-based process to preserve their geometry and copy number.

  6. Self-assembling SAS-6 multimer is a core centriole building block.

    Science.gov (United States)

    Gopalakrishnan, Jayachandran; Guichard, Paul; Smith, Andrew H; Schwarz, Heinz; Agard, David A; Marco, Sergio; Avidor-Reiss, Tomer

    2010-03-19

    Centrioles are conserved microtubule-based organelles with 9-fold symmetry that are essential for cilia and mitotic spindle formation. A conserved structure at the onset of centriole assembly is a "cartwheel" with 9-fold radial symmetry and a central tubule in its core. It remains unclear how the cartwheel is formed. The conserved centriole protein, SAS-6, is a cartwheel component that functions early in centriole formation. Here, combining biochemistry and electron microscopy, we characterize SAS-6 and show that it self-assembles into stable tetramers, which serve as building blocks for the central tubule. These results suggest that SAS-6 self-assembly may be an initial step in the formation of the cartwheel that provides the 9-fold symmetry. Electron microscopy of centrosomes identified 25-nm central tubules with repeating subunits and show that SAS-6 concentrates at the core of the cartwheel. Recombinant and native SAS-6 self-oligomerizes into tetramers with approximately 6-nm subunits, and these tetramers are components of the centrosome, suggesting that tetramers are the building blocks of the central tubule. This is further supported by the observation that elevated levels of SAS-6 in Drosophila cells resulted in higher order structures resembling central tubule morphology. Finally, in the presence of embryonic extract, SAS-6 tetramers assembled into high density complexes, providing a starting point for the eventual in vitro reconstruction of centrioles.

  7. [Generating person-years and calculating SMR using SAS: a simple program for exact calculations].

    Science.gov (United States)

    Marchand, J-L

    2010-10-01

    The computation of standardized incidence/mortality ratios or Poisson regression requires the calculation of person-years generated in a cohort. Softwares can do that, but SAS users still need to program this step themselves. Various algorithms were published previously, but they do not perform exact calculations: the present paper describes a simple program, which creates exact person-years, and computes SMRs. This program provides a referenced tool to perform this analysis in a cohort, with SAS or another language (the algorithm used can be easily adapted). Copyright © 2010 Elsevier Masson SAS. All rights reserved.

  8. SAS paneb Estonian Airi kiirmüüki / Gert D. Hankewitz

    Index Scriptorium Estoniae

    Hankewitz, Gert D.

    2009-01-01

    Majandusraskustes lennufirma SAS kavatseb loobuda osalustest kõigis lennufirmades, mis ei sobi kokku nende uue tegevuskavaga. Majandus- ja kommunikatsiooniminister Juhan Parts arvab, et riik peaks leidma Estonian Airile kodumaised partnerid

  9. Physicochemical properties and oral bioavailability of ursolic acid nanoparticles using supercritical anti-solvent (SAS) process.

    Science.gov (United States)

    Yang, Lei; Sun, Zhen; Zu, Yuangang; Zhao, Chunjian; Sun, Xiaowei; Zhang, Zhonghua; Zhang, Lin

    2012-05-01

    The objective of the study was to prepare ursolic acid (UA) nanoparticles using the supercritical anti-solvent (SAS) process and evaluate its physicochemical properties and oral bioavailability. The effects of four process variables, pressure, temperature, drug concentration and drug solution flow rate, on drug particle formation during SAS process, were investigated. Particles with mean particle size ranging from 139.2±19.7 to 1039.8±65.2nm were obtained by varying the process parameters. The UA was characterised by scanning electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, thermal gravimetric analysis, specific surface area, dissolution test and bioavailability test. It was concluded that physicochemical properties and bioavailability of crystalline UA could be improved by physical modification, such as particle size reduction and generation of amorphous state using SAS process. Further, SAS process was a powerful methodology for improving the physicochemical properties and bioavailability of UA.

  10. SAS ihub hammast Estonian Airile / Lauri Linnamäe, Meeli Vilukas

    Index Scriptorium Estoniae

    Linnamäe, Lauri

    2007-01-01

    Skandinaavia lennukompanii SAS soovib suurendada osalust Estonian Airis ja Läti airBalticus, soovides luua Baltimaade tugevaima lennufirma. Peaminister Andrus Ansipi sõnul on Eesti kaalunud oma osaluse müüki Estonian Airis. Lisa: Omanikering

  11. Reactivity and fate of secondary alkane sulfonates (SAS) in marine sediments.

    Science.gov (United States)

    Baena-Nogueras, Rosa María; Rojas-Ojeda, Patricia; Sanz, José Luis; González-Mazo, Eduardo; Lara-Martín, Pablo A

    2014-06-01

    This research is focused on secondary alkane sulfonates (SAS), anionic surfactants widely used in household applications that access aquatic environments mainly via sewage discharges. We studied their sorption capacity and anaerobic degradation in marine sediments, providing the first data available on this topic. SAS partition coefficients increased towards those homologues having longer alkyl chains (from up to 141 L kg(-1) for C14 to up to 1753 L kg(-1) for C17), which were those less susceptible to undergo biodegradation. Overall, SAS removal percentages reached up to 98% after 166 days of incubation using anoxic sediments. The degradation pathway consisted on the formation of sulfocarboxylic acids after an initial fumarate attack of the alkyl chain and successive β-oxidations. This is the first study showing that SAS can be degraded in absence of oxygen, so this new information should be taken into account for future environmental risk assessments on these chemicals.

  12. SAS 2 observation of pulsed high-energy gamma radiation from Geminga

    Science.gov (United States)

    Mattox, J. R.; Bertsch, D. L.; Fichtel, C. E.; Hartman, R. C.; Kniffen, D. A.; Thompson, D. J.

    1992-01-01

    Following the detection of pulsed X-rays and gamma rays from Geminga, the 1972-1973 SAS 2 data which first revealed this source have been reanalyzed. The 237 ms periodicity is visible in those observations. The phase of the SAS 2 periodicity is consistent with that of COS B suggesting that the gamma-ray data allow an accounting for every revolution of the Geminga pulsar between 1972 and 1982.

  13. Comparative assessment of SAS and DES turbulence modeling for massively separated flows

    Science.gov (United States)

    Zheng, Weilin; Yan, Chao; Liu, Hongkang; Luo, Dahai

    2016-02-01

    Numerical studies of the flow past a circular cylinder at Reynolds number 1.4× 105 and NACA0021 airfoil at the angle of attack 60° have been carried out by scale-adaptive simulation (SAS) and detached eddy simulation (DES), in comparison with the existing experimental data. The new version of the model developed by Egorov and Menter is assessed, and advantages and disadvantages of the SAS simulation are analyzed in detail to provide guidance for industrial application in the future. Moreover, the mechanism of the scale-adaptive characteristics in separated regions is discussed, which is obscure in previous analyses. It is concluded that: the mean flow properties satisfactorily agree with the experimental results for the SAS simulation, although the prediction of the second order turbulent statistics in the near wake region is just reasonable. The SAS model can produce a larger magnitude of the turbulent kinetic energy in the recirculation bubble, and, consequently, a smaller recirculation region and a more rapid recovery of the mean velocity outside the recirculation region than the DES approach with the same grid resolution. The vortex shedding is slightly less irregular with the SAS model than with the DES approach, probably due to the higher dissipation of the SAS simulation under the condition of the coarse mesh.

  14. SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.

    Science.gov (United States)

    Hilbert, Manuel; Noga, Akira; Frey, Daniel; Hamel, Virginie; Guichard, Paul; Kraatz, Sebastian H W; Pfreundschuh, Moritz; Hosner, Sarah; Flückiger, Isabelle; Jaussi, Rolf; Wieser, Mara M; Thieltges, Katherine M; Deupi, Xavier; Müller, Daniel J; Kammerer, Richard A; Gönczy, Pierre; Hirono, Masafumi; Steinmetz, Michel O

    2016-04-01

    Centrioles are critical for the formation of centrosomes, cilia and flagella in eukaryotes. They are thought to assemble around a nine-fold symmetric cartwheel structure established by SAS-6 proteins. Here, we have engineered Chlamydomonas reinhardtii SAS-6-based oligomers with symmetries ranging from five- to ten-fold. Expression of a SAS-6 mutant that forms six-fold symmetric cartwheel structures in vitro resulted in cartwheels and centrioles with eight- or nine-fold symmetries in vivo. In combination with Bld10 mutants that weaken cartwheel-microtubule interactions, this SAS-6 mutant produced six- to eight-fold symmetric cartwheels. Concurrently, the microtubule wall maintained eight- and nine-fold symmetries. Expressing SAS-6 with analogous mutations in human cells resulted in nine-fold symmetric centrioles that exhibited impaired length and organization. Together, our data suggest that the self-assembly properties of SAS-6 instruct cartwheel symmetry, and lead us to propose a model in which the cartwheel and the microtubule wall assemble in an interdependent manner to establish the native architecture of centrioles.

  15. Preparation and pharmaceutical characterization of amorphous cefdinir using spray-drying and SAS-process.

    Science.gov (United States)

    Park, Junsung; Park, Hee Jun; Cho, Wonkyung; Cha, Kwang-Ho; Kang, Young-Shin; Hwang, Sung-Joo

    2010-08-30

    The aim of this study was to investigate the effects of micronization and amorphorization of cefdinir on solubility and dissolution rate. The amorphous samples were prepared by spray-drying (SD) and supercritical anti-solvent (SAS) process, respectively and their amorphous natures were confirmed by DSC, PXRD and FT-IR. Thermal gravimetric analysis was performed by TGA. SEM was used to investigate the morphology of particles and the processed particle had a spherical shape, while the unprocessed crystalline particle had a needle-like shape. The mean particle size and specific surface area were measured by dynamic light scattering (DLS) and BET, respectively. The DLS result showed that the SAS-processed particle was the smallest, followed by SD and the unprocessed cefdinir. The BET result was the same as DLS result in that the SAS-processed particle had the largest surface area. Therefore, the processed cefdinir, especially the SAS-processed particle, appeared to have enhanced apparent solubility, improved intrinsic dissolution rate and better drug release when compared with SD-processed and unprocessed crystalline cefdinir due not only to its amorphous nature, but also its reduced particle size. Conclusions were that the solubility and dissolution rate of crystalline cefdinir could be improved by physically modifying the particles using SD and SAS-process. Furthermore, SAS-process was a powerful methodology for improving the solubility and dissolution rate of cefdinir.

  16. Different Effects of Startling Acoustic Stimuli (SAS) on TMS-Induced Responses at Rest and during Sustained Voluntary Contraction.

    Science.gov (United States)

    Chen, Yen-Ting; Li, Shengai; Zhou, Ping; Li, Sheng

    2016-01-01

    Previous studies have shown that a habituated startling acoustic stimulus (SAS) can cause a transient suppression of motor evoked potentials (MEPs) induced by transcranial magnetic stimulation (TMS) during light muscle contraction. However, it is still unknown whether this phenomenon persists when at rest or during a sustained voluntary contraction task. Therefore, the purpose of this study was to determine whether a conditioning SAS has different effects. TMS was delivered to the hot spot for the left biceps on 11 subjects at rest both with and without a conditioning SAS. Of the 11subjects, 9 also had TMS delivered during isometric flexion of the left elbow, also with and without a conditioning SAS. TMS-induced MEPs, TMS-induced force, and silent periods were used to determine the effect of conditioning SAS. Consistent with previous findings, TMS-induced MEPs were smaller with a conditioning SAS (0.49 ± 0.37 mV) as compared without the SAS (0.69 ± 0.52 mV) at rest. However, a conditioning SAS during the voluntary contraction tasks resulted in a significant shortening of the MEP silent period (187.22 ± 22.99 ms with SAS vs. 200.56 ± 29.71 ms without SAS) without any changes in the amplitude of the MEP (1.37 ± 0.9 mV with SAS V.S. 1.32 ± 0.92 mV without SAS) or the TMS-induced force (3.11 ± 2.03 N-m with SAS V.S. 3.62 ± 1.33 N-m without SAS). Our results provide novel evidence that a conditioning SAS has different effects on the excitability of the motor cortex when at rest or during sustained voluntary contractions.

  17. Conserved TCP domain of Sas-4/CPAP is essential for pericentriolar material tethering during centrosome biogenesis.

    Science.gov (United States)

    Zheng, Xiangdong; Gooi, Li Ming; Wason, Arpit; Gabriel, Elke; Mehrjardi, Narges Zare; Yang, Qian; Zhang, Xingrun; Debec, Alain; Basiri, Marcus L; Avidor-Reiss, Tomer; Pozniakovsky, Andrei; Poser, Ina; Saric, Tomo; Hyman, Anthony A; Li, Haitao; Gopalakrishnan, Jay

    2014-01-21

    Pericentriolar material (PCM) recruitment to centrioles forms a key step in centrosome biogenesis. Deregulation of this process leads to centrosome aberrations causing disorders, one of which is autosomal recessive primary microcephaly (MCPH), a neurodevelopmental disorder where brain size is reduced. During PCM recruitment, the conserved centrosomal protein Sas-4/CPAP/MCPH6, known to play a role in centriole formation, acts as a scaffold for cytoplasmic PCM complexes to bind and then tethers them to centrioles to form functional centrosomes. To understand Sas-4's tethering role, we determined the crystal structure of its T complex protein 10 (TCP) domain displaying a solvent-exposed single-layer of β-sheets fold. This unique feature of the TCP domain suggests that it could provide an "extended surface-like" platform to tether the Sas-4-PCM scaffold to a centriole. Functional studies in Drosophila, human cells, and human induced pluripotent stem cell-derived neural progenitor cells were used to test this hypothesis, where point mutations within the 9-10th β-strands (β9-10 mutants including a MCPH-associated mutation) perturbed PCM tethering while allowing Sas-4/CPAP to scaffold cytoplasmic PCM complexes. Specifically, the Sas-4 β9-10 mutants displayed perturbed interactions with Ana2, a centrosome duplication factor, and Bld-10, a centriole microtubule-binding protein, suggesting a role for the β9-10 surface in mediating protein-protein interactions for efficient Sas-4-PCM scaffold centriole tethering. Hence, we provide possible insights into how centrosomal protein defects result in human MCPH and how Sas-4 proteins act as a vehicle to tether PCM complexes to centrioles independent of its well-known role in centriole duplication.

  18. New Shortwave Array Spectroradiometer-Hemispheric (SAS-He): Hyperspectral Design and Initial Applications

    Energy Technology Data Exchange (ETDEWEB)

    Kassianov, Evgueni I.; Flynn, Connor J M.; Barnard, James C.; Ermold, Brian D.; Berg, Larry K.

    2016-10-31

    Aerosol optical depth (AOD) derived from hyperspectral measurements can serve as an invaluable input for simultaneous retrievals of particle size distributions and major trace gases. The required hyperspectral measurements are provided by a new ground-based radiometer, the so-called Shortwave Array Spectroradiometer-Hemispheric (SAS-He), recently developed with support from the Department of Energy (DOE) Office Atmospheric Radiation Measurement (ARM) Program. The SAS-He has wide spectral coverage (350-1700nm) and high spectral resolution: about 2.4 nm and 6 nm within 350-1000 nm and 970-1700 nm spectral ranges, respectively. To illustrate an initial performance of the SAS-He, we take advantage of integrated dataset collected during the ARM-supported Two-Column Aerosol Project (TCAP) over the US coastal region (Cape Cod, Massachusetts). This dataset includes AODs derived using data from Aerosol Robotic Network (AERONET) sunphotometer and Multi-Filter Rotating Shadowband Radiometer (MFRSR). We demonstrate that, on average, the SAS-He AODs closely match the MFRSR and AERONET AODs in the ultraviolet and visible spectral ranges for this area with highly variable AOD. Also, we discuss corrections of SAS-He total optical depth for gas absorption in the near-infrared spectral range and their operational implementation.

  19. SAS/IntrNet功能简介及初步应用

    Institute of Scientific and Technical Information of China (English)

    杨舒静; 刘沛

    2014-01-01

    目的 介绍统计分析软件(statistical analysis system,SAS)网络化模块(SAS/IntrNet)的基本功能并应用于医学实际.方法 应用SAS/IntrNet远程调用SAS程序进行在线分析,从客户端获取参数通过网络传递给服务器端的SAS程序进行分析,并反馈结果给客户端.结果 利用SAS/IntrNet程序处理流程和相关配置文件,成功地实现了在线膳食暴露评估分析实例,使得用户可以在不安装SAS软件的情况下方便地通过网页进行在线SAS统计分析.结论 利用SAS/IntrNet模块实现SAS网络化应用,可使不甚了解SAS编程的使用者通过友好的访问界面即可实现SAS的在线统计分析,大大提高了SAS系统信息共享的能力.

  20. Centriolar SAS-7 acts upstream of SPD-2 to regulate centriole assembly and pericentriolar material formation.

    Science.gov (United States)

    Sugioka, Kenji; Hamill, Danielle R; Lowry, Joshua B; McNeely, Marie E; Enrick, Molly; Richter, Alyssa C; Kiebler, Lauren E; Priess, James R; Bowerman, Bruce

    2017-01-16

    The centriole/basal body is a eukaryotic organelle that plays essential roles in cell division and signaling. Among five known core centriole proteins, SPD-2/Cep192 is the first recruited to the site of daughter centriole formation and regulates the centriolar localization of the other components in C. elegans and in humans. However, the molecular basis for SPD-2 centriolar localization remains unknown. Here we describe a new centriole component, the coiled-coil protein SAS-7, as a regulator of centriole duplication, assembly and elongation. We also show that SAS-7 binds SPD-2 and regulates SPD-2 centriolar recruitment, while SAS-7 centriolar localization is SPD-2-independent. Furthermore, pericentriolar material (PCM) formation is abnormal in sas-7 mutants, and the PCM-dependent induction of cell polarity that defines the anterior-posterior body axis frequently fails. We conclude that SAS-7 functions at the earliest step in centriole duplication yet identified and plays important roles in the orchestration of centriole and PCM assembly.

  1. Determination and occurrence of secondary alkane sulfonates (SAS) in aquatic environments.

    Science.gov (United States)

    Baena-Nogueras, Rosa María; González-Mazo, Eduardo; Lara-Martín, Pablo A

    2013-05-01

    A new methodology has been developed for the determination of secondary alkane sulfonates (SAS), an anionic surfactant, in environmental matrices. Sediment and sludge samples were extracted using pressurized liquid extraction and sonication, whereas wastewater and surface water samples were processed using solid-phase extraction. Extraction recoveries were acceptable for both aqueous (78-120%) and solid samples (83-100%). Determination of SAS was carried out by high or ultra performance liquid chromatography - mass spectrometry using ion trap and time-of-flight detectors. The methodology was applied to samples from Guadalete River (SW Spain), where SAS concentrations below 1 μg L(-1) were measured in surface water, and from 72 to 9737 μg kg(-1) in sediments. Differential partitioning was observed for SAS homologues as those having a longer hydrocarbon chain which preferentially sorbed onto particulate matter. A preliminary environmental risk assessment also showed that SAS measured levels were not harmful to the aquatic community in the sampling area.

  2. Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome.

    Science.gov (United States)

    Gopalakrishnan, Jayachandran; Mennella, Vito; Blachon, Stephanie; Zhai, Bo; Smith, Andrew H; Megraw, Timothy L; Nicastro, Daniela; Gygi, Steven P; Agard, David A; Avidor-Reiss, Tomer

    2011-06-21

    Centrosomes are conserved organelles that are essential for accurate cell division and cilium formation. A centrosome consists of a pair of centrioles surrounded by a protein network of pericentriolar material (PCM) that is essential for the centrosome's function. In this study, we show that Sas-4 provides a scaffold for cytoplasmic complexes (named S-CAP), which include CNN, Asl and D-PLP, proteins that are all found in the centrosomes at the vicinity of the centriole. When Sas-4 is absent, nascent procentrioles are unstable and lack PCM, and functional centrosomes are not generated. When Sas-4 is mutated, so that it cannot form S-CAP complexes, centrosomes are present but with dramatically reduced levels of PCM. Finally, purified S-CAP complexes or recombinant Sas-4 can bind centrosomes stripped of PCM, whereas recombinant CNN or Asl cannot. In summary, PCM assembly begins in the cytosol where Sas-4 provides a scaffold for pre-assembled cytoplasmic complexes before tethering of the complexes in a centrosome.

  3. SAS-Pro: simultaneous residue assignment and structure superposition for protein structure alignment.

    Science.gov (United States)

    Shah, Shweta B; Sahinidis, Nikolaos V

    2012-01-01

    Protein structure alignment is the problem of determining an assignment between the amino-acid residues of two given proteins in a way that maximizes a measure of similarity between the two superimposed protein structures. By identifying geometric similarities, structure alignment algorithms provide critical insights into protein functional similarities. Existing structure alignment tools adopt a two-stage approach to structure alignment by decoupling and iterating between the assignment evaluation and structure superposition problems. We introduce a novel approach, SAS-Pro, which addresses the assignment evaluation and structure superposition simultaneously by formulating the alignment problem as a single bilevel optimization problem. The new formulation does not require the sequentiality constraints, thus generalizing the scope of the alignment methodology to include non-sequential protein alignments. We employ derivative-free optimization methodologies for searching for the global optimum of the highly nonlinear and non-differentiable RMSD function encountered in the proposed model. Alignments obtained with SAS-Pro have better RMSD values and larger lengths than those obtained from other alignment tools. For non-sequential alignment problems, SAS-Pro leads to alignments with high degree of similarity with known reference alignments. The source code of SAS-Pro is available for download at http://eudoxus.cheme.cmu.edu/saspro/SAS-Pro.html.

  4. New Shortwave Array Spectroradiometer-Hemispheric (SAS-He): hyperspectral design and initial applications

    Science.gov (United States)

    Kassianov, Evgueni; Flynn, Connor; Barnard, James; Ermold, Brian; Berg, Larry

    2016-10-01

    Aerosol optical depth (AOD) derived from hyperspectral measurements can serve as an invaluable input for simultaneous retrievals of particle size distributions and major trace gases. The required hyperspectral measurements are provided by a new ground-based radiometer, the so-called Shortwave Array Spectroradiometer-Hemispheric (SAS-He), recently developed with support from the Department of Energy (DOE) Office Atmospheric Radiation Measurement (ARM) Program. The SAS-He has wide spectral coverage (350-1700nm) and high spectral resolution: about 2.4 nm and 6 nm within 350-1000 nm and 970-1700 nm spectral ranges, respectively. To illustrate an initial performance of the SAS-He, we take advantage of integrated dataset collected during the ARM-supported Two-Column Aerosol Project (TCAP) over the US coastal region (Cape Cod, Massachusetts). This dataset includes AODs derived using data from Aerosol Robotic Network (AERONET) sunphotometer and Multi-Filter Rotating Shadowband Radiometer (MFRSR). We demonstrate that, on average, the SAS-He AODs closely match the MFRSR and AERONET AODs in the ultraviolet and visible spectral ranges for this area with highly variable AOD. Also, we discuss corrections of SAS-He total optical depth for gas absorption in the near-infrared spectral range and their operational implementation

  5. Spanish Validation of the School Anxiety Scale-Teacher Report (SAS-TR).

    Science.gov (United States)

    Orgilés, Mireia; Fernández-Martínez, Iván; Lera-Miguel, Sara; Marzo, Juan Carlos; Medrano, Laura; Espada, José Pedro

    2016-11-04

    This study aimed to examine the factorial structure and psychometric properties of the School Anxiety Scale-Teacher Report (SAS-TR) in a community sample of 315 Spanish children aged 5 to 12 years. Thirty-seven teachers from eleven schools completed the SAS-TR and the Strengths and Difficulties Questionnaire (SDQ) for each child. Confirmatory factor analysis supported the original two-factor structure, but a better fit model was obtained after removing four items. The scale was found to have high internal consistency (α = 0.91) and satisfactory test-retest reliability (ICC = 0.87) for the Spanish sample. Convergent validity was supported by positive significant correlations between the SAS-TR and the Emotional Symptoms subscale of the SDQ. Lower correlations between the SAS-TR and the SDQ Conduct Problems subscale supported the divergent validity. Overall, the findings suggest that the Spanish version of the SAS-TR is a reliable and valid instrument for teachers to assess anxiety in Spanish children.

  6. 基于SAS/IntrNet的预测系统实现%Implementation of Forecasting System Based on SAS/IntrNet

    Institute of Scientific and Technical Information of China (English)

    谢红

    2008-01-01

    SAS是一个使用广泛的大型模块化的应用软件系统,具有强大的数据分析和管理能力.文章以预测系统的实现为例,介绍如何使用SAS/IntrNet组件,实现SAS和J2EEWEB技术的结合.

  7. The SAS-5 N-terminal domain is a tetramer, with implications for centriole assembly in C. elegans.

    Science.gov (United States)

    Shimanovskaya, Ekaterina; Qiao, Renping; Lesigang, Johannes; Dong, Gang

    2013-07-01

    The centriole is a conserved microtubule-based organelle essential for both centrosome formation and cilium biogenesis. It has a unique 9-fold symmetry and its assembly is governed by at least five component proteins (SPD-2, ZYG-1, SAS-5, SAS-6 and SAS-4), which are recruited in a hierarchical order. Recently published structural studies of the SAS-6 N-terminal domain have greatly advanced our understanding of the mechanisms of centriole assembly. However, it remains unclear how the weak interaction between the SAS-6 N-terminal head groups could drive the assembly of a closed ring-like structure, and what determines the stacking of multiple rings on top one another in centriole duplication. We recently reported that SAS-5 binds specifically to a very narrow region of the SAS-6 central coiled coil through its C-terminal domain (CTD, residues 391-404). Here, we further demonstrate by both static light scattering and small angle X-ray scattering that the SAS-5 N-terminal domain (NTD, residues 1-260) forms a tetramer. Specifically, we found that the tetramer is formed by SAS-5 residues 82-260, whereas residues 1-81 are intrinsically disordered. Taking these results together, we propose a working model for SAS-5-mediated assembly of the multi-layered central tube structure.

  8. Smoothing point data into maps using SAS/GRAPH (trade name) software. Forest Service research note

    Energy Technology Data Exchange (ETDEWEB)

    Chojnacky, D.C.; Rubey, M.E.

    1996-01-01

    Point of plot data are commonly available for mapping forest landscapes. Because such data are sampled, mapping a complete coverage usually requires some type of interpolation between plots. SAS/GRAPH software includes the G3GRID procedure for interpolating or smoothing this type of data to map with G3D or GCONTOUR procedures. However, the smoothing process in G3GRID is not easily controlled, nor can it be used to display missing data within rectangular grid maps. These shortcomings motivated development of SAS code that prepares point data for display in mapping units. This code links well with the rest of the SAS system to allow for powerful, easily controlled data analysis within mapping units. Examples are given for mapping forest vegetation with the GMAP procedure.

  9. The Artful Use of SAS/OR Software for Solving Integer Linear Programming with Many Solutions%巧用SAS/OR软件求解多解整数线性规划

    Institute of Scientific and Technical Information of China (English)

    邹祥福

    2004-01-01

    通过实例讲解如何巧用SAS/OR软件求解多解整数线性规划问题的多个解,弥补了用SAS/OR软件仅能得出多解整数线性规划一个解的缺点,使SAS/OR软件有了更广阔的应用.

  10. Comparing fibre channel, serial attached SCSI (SAS) and serial ATA (SATA)

    OpenAIRE

    Lam, Hin Wing Allen

    2009-01-01

    Serial Attached SCSI (SAS), Serial ATA (SATA) and Fibre Channel (FC) are the main storage interconnect technologies at present. FC is the main interconnect in Storage Area Network (SAN) with a well-known high performance and strong foundation of SCSI. SATA is the most cost-effective and high capacity in the hard drive market. On the other hand, SAS is just picking-up the momentum in both storage and hard drive areas and positions itself as a potential player. All three of these technologies h...

  11. Univariate and multivariate general linear models theory and applications with SAS

    CERN Document Server

    Kim, Kevin

    2006-01-01

    Reviewing the theory of the general linear model (GLM) using a general framework, Univariate and Multivariate General Linear Models: Theory and Applications with SAS, Second Edition presents analyses of simple and complex models, both univariate and multivariate, that employ data sets from a variety of disciplines, such as the social and behavioral sciences.With revised examples that include options available using SAS 9.0, this expanded edition divides theory from applications within each chapter. Following an overview of the GLM, the book introduces unrestricted GLMs to analyze multiple regr

  12. Median and quantile tests under complex survey design using SAS and R.

    Science.gov (United States)

    Pan, Yi; Caudill, Samuel P; Li, Ruosha; Caldwell, Kathleen L

    2014-11-01

    Techniques for conducting hypothesis testing on the median and other quantiles of two or more subgroups under complex survey design are limited. In this paper, we introduce programs in both SAS and R to perform such a test. A detailed illustration of the computations, macro variable definitions, input and output for the SAS and R programs are also included in the text. Urinary iodine data from National Health and Nutrition Examination Survey (NHANES) are used as examples for comparing medians between females and males as well as comparing the 75th percentiles among three salt consumption groups.

  13. A SAS-macro for estimation of the cumulative incidence using Poisson regression

    DEFF Research Database (Denmark)

    Waltoft, Berit Lindum

    2009-01-01

    the hazard rates, and the hazard rates are often estimated by the Cox regression. This procedure may not be suitable for large studies due to limited computer resources. Instead one uses Poisson regression, which approximates the Cox regression. Rosthøj et al. presented a SAS-macro for the estimation...... of the cumulative incidences based on the Cox regression. I present the functional form of the probabilities and variances when using piecewise constant hazard rates and a SAS-macro for the estimation using Poisson regression. The use of the macro is demonstrated through examples and compared to the macro presented...

  14. Testing the Short and Screener versions of the Social Adjustment Scale-Self-report (SAS-SR).

    Science.gov (United States)

    Gameroff, Marc J; Wickramaratne, Priya; Weissman, Myrna M

    2012-03-01

    The 54-item Social Adjustment Scale-Self-report (SAS-SR) is a measure of social functioning used in research studies and clinical practice. Two shortened versions were recently developed: the 24-item SAS-SR: Short and the 14-item SAS-SR: Screener. We briefly describe the development of the shortened scales and then assess their reliability and validity in comparison to the full SAS-SR in new analyses from two separate samples of convenience from a family study and from a primary care clinic. Compared to the full SAS-SR, the shortened scales performed well, exhibiting high correlations with full SAS-SR scores (r values between 0.81 and 0.95); significant correlations with health-related quality of life as measured by the Short Form 36 Health Survey; the ability to distinguish subjects with major depression versus other psychiatric disorders versus no mental disorders; and sensitivity to change in clinical status as measured longitudinally with the Symptom Checklist-90 and Global Assessment Scale. The SAS-SR: Short and SAS-SR: Screener retained the areas assessed by the full SAS-SR with fewer items in each area, and appear to be promising replacements for the full scale when a shorter administration time is desired and detailed information on performance in different areas is not required. Further work is needed to test the validity of the shortened measures.

  15. SAS-4 Protein in Trypanosoma brucei Controls Life Cycle Transitions by Modulating the Length of the Flagellum Attachment Zone Filament.

    Science.gov (United States)

    Hu, Huiqing; Zhou, Qing; Li, Ziyin

    2015-12-18

    The evolutionarily conserved centriole/basal body protein SAS-4 regulates centriole duplication in metazoa and basal body duplication in flagellated and ciliated organisms. Here, we report that the SAS-4 homolog in the flagellated protozoan Trypanosoma brucei, TbSAS-4, plays an unusual role in controlling life cycle transitions by regulating the length of the flagellum attachment zone (FAZ) filament, a specialized cytoskeletal structure required for flagellum adhesion and cell morphogenesis. TbSAS-4 is concentrated at the distal tip of the FAZ filament, and depletion of TbSAS-4 in the trypomastigote form disrupts the elongation of the new FAZ filament, generating cells with a shorter FAZ associated with a longer unattached flagellum and repositioned kinetoplast and basal body, reminiscent of epimastigote-like morphology. Further, we show that TbSAS-4 associates with six additional FAZ tip proteins, and depletion of TbSAS-4 disrupts the enrichment of these FAZ tip proteins at the new FAZ tip, suggesting a role of TbSAS-4 in maintaining the integrity of this FAZ tip protein complex. Together, these results uncover a novel function of TbSAS-4 in regulating the length of the FAZ filament to control basal body positioning and life cycle transitions in T. brucei.

  16. The Centriole Cartwheel Protein SAS-6 in Trypanosoma brucei Is Required for Probasal Body Biogenesis and Flagellum Assembly.

    Science.gov (United States)

    Hu, Huiqing; Liu, Yi; Zhou, Qing; Siegel, Sara; Li, Ziyin

    2015-09-01

    The centriole in eukaryotes functions as the cell's microtubule-organizing center (MTOC) to nucleate spindle assembly, and its biogenesis requires an evolutionarily conserved protein, SAS-6, which assembles the centriole cartwheel. Trypanosoma brucei, an early branching protozoan, possesses the basal body as its MTOC to nucleate flagellum biogenesis. However, little is known about the components of the basal body and their roles in basal body biogenesis and flagellum assembly. Here, we report that the T. brucei SAS-6 homolog, TbSAS-6, is localized to the mature basal body and the probasal body throughout the cell cycle. RNA interference (RNAi) of TbSAS-6 inhibited probasal body biogenesis, compromised flagellum assembly, and caused cytokinesis arrest. Surprisingly, overexpression of TbSAS-6 in T. brucei also impaired probasal body duplication and flagellum assembly, contrary to SAS-6 overexpression in humans, which produces supernumerary centrioles. Furthermore, we showed that depletion of T. brucei Polo-like kinase, TbPLK, or inhibition of TbPLK activity did not abolish TbSAS-6 localization to the basal body, in contrast to the essential role of Polo-like kinase in recruiting SAS-6 to centrioles in animals. Altogether, these results identified the essential role of TbSAS-6 in probasal body biogenesis and flagellum assembly and suggest the presence of a TbPLK-independent pathway governing basal body duplication in T. brucei.

  17. SAS võib omapoolse panusena kustutada osa Estonian Airi laenust / Gert D. Hankewitz

    Index Scriptorium Estoniae

    Hankewitz, Gert D.

    2011-01-01

    Lennufirma SAS investorsuhete asepresidendi Sture Stoleni sõnul ei ole tõenäoline, et nende firma maksaks mingit raha Estonian Airi kapitali, küll aga ei saa välistada võimalust, et võidakse kustutada osa antud laenust

  18. Essentials of Excel, Excel VBA, SAS and Minitab for statistical and financial analyses

    CERN Document Server

    Lee, Cheng-Few; Chang, Jow-Ran; Tai, Tzu

    2016-01-01

    This introductory textbook for business statistics teaches statistical analysis and research methods via business case studies and financial data using Excel, MINITAB, and SAS. Every chapter in this textbook engages the reader with data of individual stock, stock indices, options, and futures. One studies and uses statistics to learn how to study, analyze, and understand a data set of particular interest. Some of the more popular statistical programs that have been developed to use statistical and computational methods to analyze data sets are SAS, SPSS, and MINITAB. Of those, we look at MINITAB and SAS in this textbook. One of the main reasons to use MINITAB is that it is the easiest to use among the popular statistical programs. We look at SAS because it is the leading statistical package used in industry. We also utilize the much less costly and ubiquitous Microsoft Excel to do statistical analysis, as the benefits of Excel have become widely recognized in the academic world and its analytical capabilities...

  19. A new SAS program for behavioral analysis of Electrical Penetration Graph (EPG) data

    Science.gov (United States)

    A new program is introduced that uses SAS software to duplicate output of descriptive statistics from the Sarria Excel workbook for EPG waveform analysis. Not only are publishable means and standard errors or deviations output, the user also is guided through four relatively simple sub-programs for ...

  20. Measuring Statistics Anxiety: Cross-Country Validity of the Statistical Anxiety Scale (SAS)

    Science.gov (United States)

    Chiesi, Francesca; Primi, Caterina; Carmona, Jose

    2011-01-01

    The aim of the research was to test the psychometric properties of the Italian version of the Vigil-Colet et al.'s Statistical Anxiety Scale (SAS), taking into account evidences based on (a) internal structure (factorial structure and cross-country invariance) and (b) relationships to other variables (the statistics anxiety's nomological network).…

  1. Kuue riigi tudengid mängivad Radisson SAS hotelli juhatust / Agne Narusk

    Index Scriptorium Estoniae

    Narusk, Agne

    2003-01-01

    90 soome, eesti, ungari, prantsusmaa, hollandi ja belgia tudengit kehastuvad Radisson SAS hotellide rahvusvahelise juhatuse liikmeteks ja esitavad kujuteldavale aktsionäride üldkoosolekule nägemuse uutest võimalikest hotellidest. Hotelliülesanded koostas Eesti Kõrgema Kommertskooli (EBS) ettevõtluse õppetooli lektor Elena Pruvli

  2. SAS pani Estonian Airi aktsiad müüki / Riina Kallas, Tuuli Aug

    Index Scriptorium Estoniae

    Kallas, Riina

    2009-01-01

    SAS müüb enamusosaluse Estonian Airis ja veel kuues tütarfirmas, majandus- ja kommunikatsiooniminister Juhan Parts näeb Estonian Airi uue osanikuna mõnda Eesti investorit. Endise Estonian Airi presidendi Erki Urva arvamus

  3. SAS-2 high-energy gamma-ray observations of the Vela pulsar. II

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Kniffen, D. A.; Ogelman, H. B.

    1977-01-01

    Analysis of additional data from SAS-2 experiment and improvements in the orbit-attitude data and analysis procedures have produced revised values for the flux from the Vela gamma-ray source. The pulsar phase plot shows two peaks, neither of which is in phase with the single radio pulse.

  4. Clinical SAS programming in India: A study of industry needs versus wants

    Directory of Open Access Journals (Sweden)

    Nithiyanandhan Ananthakrishnan

    2014-01-01

    Full Text Available Background: The clinical SAS (www.sas.com programming industry, in India, has seen a rapid growth in the last decade and the trend seems set to continue, for the next couple of years, due to cost advantage and the availability of skilled labor. On one side the industry needs are focused on less execution time, high margins, segmented tasks and the delivery of high quality output with minimal oversight. On the other side, due to the increased demand for skilled resources, the wants of the programmers have taken a different shift toward diversifying exposure, unsustainable wage inflation due to multiple opportunities and generally high expectations around career progression. If the industry needs are not going to match with programmers want, or vice versa, then there is the possibility that the current year on year growth may start to slow or even go into decline. Aim: This paper is intended to identify the gap between wants and need and puts forwards some suggestions, for both sides, in ways to change the equation to benefit all. Settings and Design: Questionnaire on similar themes created to survey managers and programmers working in clinical SAS programming industry and was surveyed online to collect their perspectives. Their views are compared for each theme and presented as results. Materials and Methods: Two surveys were created in www.surveymonkey.com. Management: https://www.surveymonkey.com/s/SAS_India_managment_needvswant_survey. Programmer: https://www.surveymonkey.com/s/SAS_India_programmer_needvswant_survey. Statistical Analysis Used: Bar chart and pie chart used on data collect to show segmentation of data. Results and Conclusions: In conclusion, it seeks to highlight the future industry direction and the skillset that existing programmers need to have, in order to sustain the momentum and remain competitive, to contribute to the future pipeline and the development of the profession in India.

  5. The SAS4A/SASSYS-1 Safety Analysis Code System, Version 5

    Energy Technology Data Exchange (ETDEWEB)

    Fanning, T. H. [Argonne National Lab. (ANL), Argonne, IL (United States); Brunett, A. J. [Argonne National Lab. (ANL), Argonne, IL (United States); Sumner, T. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-01-01

    The SAS4A/SASSYS-1 computer code is developed by Argonne National Laboratory for thermal, hydraulic, and neutronic analysis of power and flow transients in liquidmetal- cooled nuclear reactors (LMRs). SAS4A was developed to analyze severe core disruption accidents with coolant boiling and fuel melting and relocation, initiated by a very low probability coincidence of an accident precursor and failure of one or more safety systems. SASSYS-1, originally developed to address loss-of-decay-heat-removal accidents, has evolved into a tool for margin assessment in design basis accident (DBA) analysis and for consequence assessment in beyond-design-basis accident (BDBA) analysis. SAS4A contains detailed, mechanistic models of transient thermal, hydraulic, neutronic, and mechanical phenomena to describe the response of the reactor core, its coolant, fuel elements, and structural members to accident conditions. The core channel models in SAS4A provide the capability to analyze the initial phase of core disruptive accidents, through coolant heat-up and boiling, fuel element failure, and fuel melting and relocation. Originally developed to analyze oxide fuel clad with stainless steel, the models in SAS4A have been extended and specialized to metallic fuel with advanced alloy cladding. SASSYS-1 provides the capability to perform a detailed thermal/hydraulic simulation of the primary and secondary sodium coolant circuits and the balance-ofplant steam/water circuit. These sodium and steam circuit models include component models for heat exchangers, pumps, valves, turbines, and condensers, and thermal/hydraulic models of pipes and plena. SASSYS-1 also contains a plant protection and control system modeling capability, which provides digital representations of reactor, pump, and valve controllers and their response to input signal changes.

  6. Coupling the System Analysis Module with SAS4A/SASSYS-1

    Energy Technology Data Exchange (ETDEWEB)

    Fanning, T. H. [Argonne National Lab. (ANL), Argonne, IL (United States); Hu, R. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-09-30

    SAS4A/SASSYS-1 is a simulation tool used to perform deterministic analysis of anticipated events as well as design basis and beyond design basis accidents for advanced reactors, with an emphasis on sodium fast reactors. SAS4A/SASSYS-1 has been under development and in active use for nearly forty-five years, and is currently maintained by the U.S. Department of Energy under the Office of Advanced Reactor Technology. Although SAS4A/SASSYS-1 contains a very capable primary and intermediate system modeling component, PRIMAR-4, it also has some shortcomings: outdated data management and code structure makes extension of the PRIMAR-4 module somewhat difficult. The user input format for PRIMAR-4 also limits the number of volumes and segments that can be used to describe a given system. The System Analysis Module (SAM) is a fairly new code development effort being carried out under the U.S. DOE Nuclear Energy Advanced Modeling and Simulation (NEAMS) program. SAM is being developed with advanced physical models, numerical methods, and software engineering practices; however, it is currently somewhat limited in the system components and phenomena that can be represented. For example, component models for electromagnetic pumps and multi-layer stratified volumes have not yet been developed. Nor is there support for a balance of plant model. Similarly, system-level phenomena such as control-rod driveline expansion and vessel elongation are not represented. This report documents fiscal year 2016 work that was carried out to couple the transient safety analysis capabilities of SAS4A/SASSYS-1 with the system modeling capabilities of SAM under the joint support of the ART and NEAMS programs. The coupling effort was successful and is demonstrated by evaluating an unprotected loss of flow transient for the Advanced Burner Test Reactor (ABTR) design. There are differences between the stand-alone SAS4A/SASSYS-1 simulations and the coupled SAS/SAM simulations, but these are mainly

  7. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT-A AND A ENVIRONMENTAL SEALS, INC., SEAL ASSIST SYSTEM (SAS) PHASE II REPORT

    Science.gov (United States)

    The Environmental Technology Verification report discusses the technology and performance of Seal Assist System (SAS) for natural gas reciprocating compressor rod packing manufactured by A&A Environmental Seals, Inc. The SAS uses a secondary containment gland to collect natural g...

  8. Houston, We Have a Problem: Teachers Find No Value in the SAS Education Value-Added Assessment System (EVAAS®)

    Science.gov (United States)

    Collins, Clarin

    2014-01-01

    This study examined the SAS Education Value-Added Assessment System (EVAAS®) in practice, as perceived and experienced by teachers in the Southwest School District (SSD). To evaluate teacher effectiveness, SSD is using SAS EVAAS® for high-stakes consequences more than any other district or state in the country. A mixed-method design including a…

  9. Unsteady Simulations of the Flow in a Channel Flow and a Ventilated Room Using the SST-SAS Model

    DEFF Research Database (Denmark)

    Davidson, Lars; Nielsen, Peter V.

    -SAS model is evaluated for two flows: developing channel flow and the flow in a three-dimensional ventilated room. Unsteady inlet boundary conditions are prescribed in both cases by superimposing isotropic synthetic fluctuations on a steady inlet boundary velocity profile.......The SAS model (Scale Adapted Simulation) was invented by Menter and his co-workers. The idea behind the SST-SAS model is to add an additional production term - the SAS term - in the w equation which is sensitive to resolved (i.e. unsteady) fluctuations. In regions where the flow is on the limit...... of going unsteady, the object of the SAS term is to increase w. The result is that k and vt are reduced so that the dissipating (damping) effect of the turbulent viscosity on the resolved fluctuations is reduced, thereby promoting the momentum equations to switch from steady to unsteady mode. The SST...

  10. SAS macro programs for geographically weighted generalized linear modeling with spatial point data: applications to health research.

    Science.gov (United States)

    Chen, Vivian Yi-Ju; Yang, Tse-Chuan

    2012-08-01

    An increasing interest in exploring spatial non-stationarity has generated several specialized analytic software programs; however, few of these programs can be integrated natively into a well-developed statistical environment such as SAS. We not only developed a set of SAS macro programs to fill this gap, but also expanded the geographically weighted generalized linear modeling (GWGLM) by integrating the strengths of SAS into the GWGLM framework. Three features distinguish our work. First, the macro programs of this study provide more kernel weighting functions than the existing programs. Second, with our codes the users are able to better specify the bandwidth selection process compared to the capabilities of existing programs. Third, the development of the macro programs is fully embedded in the SAS environment, providing great potential for future exploration of complicated spatially varying coefficient models in other disciplines. We provided three empirical examples to illustrate the use of the SAS macro programs and demonstrated the advantages explained above.

  11. Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry.

    Science.gov (United States)

    Hilbert, Manuel; Erat, Michèle C; Hachet, Virginie; Guichard, Paul; Blank, Iris D; Flückiger, Isabelle; Slater, Leanne; Lowe, Edward D; Hatzopoulos, Georgios N; Steinmetz, Michel O; Gönczy, Pierre; Vakonakis, Ioannis

    2013-07-09

    Centrioles are evolutionary conserved organelles that give rise to cilia and flagella as well as centrosomes. Centrioles display a characteristic ninefold symmetry imposed by the spindle assembly abnormal protein 6 (SAS-6) family. SAS-6 from Chlamydomonas reinhardtii and Danio rerio was shown to form ninefold symmetric, ring-shaped oligomers in vitro that were similar to the cartwheels observed in vivo during early steps of centriole assembly in most species. Here, we report crystallographic and EM analyses showing that, instead, Caenorhabotis elegans SAS-6 self-assembles into a spiral arrangement. Remarkably, we find that this spiral arrangement is also consistent with ninefold symmetry, suggesting that two distinct SAS-6 oligomerization architectures can direct the same output symmetry. Sequence analysis suggests that SAS-6 spirals are restricted to specific nematodes. This oligomeric arrangement may provide a structural basis for the presence of a central tube instead of a cartwheel during centriole assembly in these species.

  12. Aerosol Optical Depth Value-Added Product for the SAS-He Instrument

    Energy Technology Data Exchange (ETDEWEB)

    Ermold, B [Pacific Northwest National Laboratory; Flynn, CJ [Pacific Northwest National Laboratory; Barnard, J [University of Nevada Reno

    2013-11-27

    The Shortwave Array Spectroradiometer – Hemispheric (SAS-He) is a ground-based, shadowband instrument that measures the direct and diffuse solar irradiance. In this regard, the instrument is similar to the Multi-Filter Rotating Shadowband Radiometer (MFRSR) – an instrument that has been in the ARM suite of instruments for more than 15 years. However, the two instruments differ significantly in wavelength resolution and range. In particular, the MFRSR only observes the spectrum in six discrete wavelength channels of about 10 nm width from 415 to 940 nm. The SAS-He, in contrast, incorporates two fiber-coupled grating spectrometers: a Si CCD spectrometer with over 2000 pixels covering the range from 325-1040 nm with ~ 2.5 nm resolution ,and an InGaAs array spectrometer with 256 pixels covering the wavelength range from 960-1700 nm with ~ 6 nm resolution.

  13. SPSS and SAS programs for comparing Pearson correlations and OLS regression coefficients.

    Science.gov (United States)

    Weaver, Bruce; Wuensch, Karl L

    2013-09-01

    Several procedures that use summary data to test hypotheses about Pearson correlations and ordinary least squares regression coefficients have been described in various books and articles. To our knowledge, however, no single resource describes all of the most common tests. Furthermore, many of these tests have not yet been implemented in popular statistical software packages such as SPSS and SAS. In this article, we describe all of the most common tests and provide SPSS and SAS programs to perform them. When they are applicable, our code also computes 100 × (1 - α)% confidence intervals corresponding to the tests. For testing hypotheses about independent regression coefficients, we demonstrate one method that uses summary data and another that uses raw data (i.e., Potthoff analysis). When the raw data are available, the latter method is preferred, because use of summary data entails some loss of precision due to rounding.

  14. POWERLIB: SAS/IML Software for Computing Power in Multivariate Linear Models

    Directory of Open Access Journals (Sweden)

    Jacqueline L. Johnson

    2009-04-01

    Full Text Available The POWERLIB SAS/IML software provides convenient power calculations for a widerange of multivariate linear models with Gaussian errors. The software includes the Box,Geisser-Greenhouse, Huynh-Feldt, and uncorrected tests in the univariate" approach torepeated measures (UNIREP, the Hotelling Lawley Trace, Pillai-Bartlett Trace, andWilks Lambda tests in multivariate" approach (MULTIREP, as well as a limited butuseful range of mixed models. The familiar univariate linear model with Gaussian errorsis an important special case. For estimated covariance, the software provides condencelimits for the resulting estimated power. All power and condence limits values canbe output to a SAS dataset, which can be used to easily produce plots and tables formanuscripts.

  15. PREFACE Proceedings of the XIV International Conference on Small-Angle Scattering, SAS-2009

    Science.gov (United States)

    King, Stephen; Terrill, Nicholas

    2010-10-01

    The XIV International Conference on Small-Angle Scattering, SAS-2009, was held in Oxford UK, 13-18 September 2009, and was jointly organised under the auspices of the International Union of Crystallography Commission on SAS by a team from the Diamond Light Source and the ISIS Pulsed Neutron Source - their first such joint venture - with help from the UK Science and Technology Facilities Council. It was the first time that this long running and successful series of conferences on the application, science and technology of small-angle scattering techniques had been staged in the UK. The UK has a proud heritage in small-angle scattering: as home to one of the world's first SANS instruments (at AERE Harwell), as the site of the world's first 2nd generation X-ray Synchrotron (the SRS at Daresbury with its suite of SAXS beamlines), and latterly as the location of the world's most successful pulsed source SANS instrument. Indeed, 2009 also marked the 25th Anniversary of neutron operations at ISIS and the opening of a Second Target Station. Whilst the SRS ceased operations in 2008, its mantle has been inherited by the Diamond synchrotron. Many delegates took the opportunity to visit both Diamond and ISIS during a conference excursion. Despite the prevailing global economic downturn, we were delighted that 434 delegates from 32 different countries were able to attend SAS-2009; two-thirds were drawn from the UK, Germany, Japan, the USA and France, but there were also sizeable contingents from Australia, Korea, Taiwan and South America. In many ways this geographical spread reflects the present and emerging distribution, respectively, of 3rd generation X-ray synchrotrons and high-flux neutron sources, although the scope of the conference was not solely limited to these probes. Financial support from the IUCr enabled us to grant bursaries to attend SAS-2009 to 12 delegates from emerging countries (Algeria, Argentina, Brazil, India, Nepal, Romania, Russia and the Ukraine). The

  16. SAS 2.0丰收期即将到来?

    Institute of Scientific and Technical Information of China (English)

    袁绍龙

    2009-01-01

    @@ SAS技术诞生8年以来经历了重重考验,现在SAS2.0走入产品化,也意味着苦熬多年的SAS技术即将迎来自己的丰收期. 2001年11月26号,Compaq、IBM、LSI、Maxtor和Seagate联合宣布成立SAS(Serial Attached SCSI,也称串行SCSI)工作组,标志着SAS正式走入存储的舞台.一晃近8年时间过去了,从刚开始的广泛质疑到现在的逐渐接受,SAS技术在这8年中经历了重重考验.

  17. SAS-2 observations of celestial diffuse gamma radiation above 30 MeV

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Kniffen, D. A.; Hartman, R. C.

    1974-01-01

    The small astronomy satellite, SAS-2, used a 32-deck magnetic core digitized spark chamber to study gamma rays with energies above 30 MeV. Data for four regions of the sky away from the galactic plane were analyzed. These regions show a finite, diffuse flux of gamma rays with a steep energy spectrum, and the flux is uniform over all the regions. Represented by a power law, the differential energy spectrum shows an index of 2.5 + or - 0.4. The steep SAS-2 spectrum and the lower energy data are reasonably consistent with a neutral pion gamma-ray spectrum which was red-shifted (such as that proposed by some cosmological theories). It is concluded that the diffuse celestial gamma ray spectrum observed presents the possibility of cosmological studies and possible evidence for a residual cosmic ray density, and supports the galactic superclusters of matter and antimatter remaining from baryon-symmetric big bang.

  18. The PLK4-STIL-SAS-6 module at the core of centriole duplication.

    Science.gov (United States)

    Arquint, Christian; Nigg, Erich A

    2016-10-15

    Centrioles are microtubule-based core components of centrosomes and cilia. They are duplicated exactly once during S-phase progression. Central to formation of each new (daughter) centriole is the formation of a nine-fold symmetrical cartwheel structure onto which microtubule triplets are deposited. In recent years, a module comprising the protein kinase polo-like kinase 4 (PLK4) and the two proteins STIL and SAS-6 have been shown to stay at the core of centriole duplication. Depletion of any one of these three proteins blocks centriole duplication and, conversely, overexpression causes centriole amplification. In this short review article, we summarize recent insights into how PLK4, STIL and SAS-6 co-operate in space and time to form a new centriole. These advances begin to shed light on the very first steps of centriole biogenesis.

  19. Síndrome de apnea del sueño (SAS Sleep apnea syndrome

    Directory of Open Access Journals (Sweden)

    Camilo José Borrego Abello

    1994-03-01

    Full Text Available Se describe el síndrome de apnea del sueño (SAS abarcando los aspectos históricos, signos y síntomas, las diversas modalidades (apneas obstructiva, central y mixta, complicaciones, principalmente cardiovasculares y cerebrovasculares y formas de tratamiento. Se hace énfasis en la ayuda diagnóstica del polisomnograma que ha permitido definir como SAS síntomas antes considerados inespecíficos y cuantificar su gravedad. Se describen las diversas medidas terapéuticas, locales y generales, recalcando los beneficios que se obtienen con la aplicación de los aparatos de respiración a presión positiva. Estos permiten tratamientos no invasivos que hacen desaparecer la totalidad de los síntomas y evitan los riesgos incrementados de trastornos cardiovasculares y accidentes laborales o de tránsito. Este grave síndrome afecta a un grupo grande de población por lo que su importancia es indudable.

    Different aspects of the sleep apnea síndrome (SAS are described, including history, clinical manifestations, clinical forms (obstructive, central and mixed, cardiovascular, cerebrovascular and other complications and treatment. With the use of the polysomnogram it has been possible to define non-specific symptoms as due to SAS and to quantitate their seriousness. Different therapeutic approaches are described, both local and systemic, with emphasis on the benefits obtained from the use of positive pressure breathing machines which control every manifestation of the syndrome and avoid the increased cardiovascular risks aswell as work and traffic accidents. This syndrome is important in terms of frequency and of increased death risk.

  20. Simple and flexible SAS and SPSS programs for analyzing lag-sequential categorical data.

    Science.gov (United States)

    O'Connor, B P

    1999-11-01

    This paper describes simple and flexible programs for analyzing lag-sequential categorical data, using SAS and SPSS. The programs read a stream of codes and produce a variety of lag-sequential statistics, including transitional frequencies, expected transitional frequencies, transitional probabilities, adjusted residuals, z values, Yule's Q values, likelihood ratio tests of stationarity across time and homogeneity across groups or segments, transformed kappas for unidirectional dependence, bidirectional dependence, parallel and nonparallel dominance, and significance levels based on both parametric and randomization tests.

  1. Immunomagnetic separation and visual fluorescence detection of Salmonella spp., using AOAC approved SAS Molecular Tests.

    Science.gov (United States)

    Bapanpally, Chandra; Maganty, Gayatri; Khan, Shah; Kasra, Akif; Morey, Amit

    2014-01-01

    The SAS Molecular Tests method for detection of Salmonella spp. in various food matrixes has been certified by the AOAC Research Institute and designated Performance Tested Method No. 021202. The current method modification includes the optional immunomagnetic separation (IMS) to enrich the bacteria as well as optional visual fluorescence readout without the use of a turbidimeter. The modifications were validated against the U.S. Department of Agriculture/ Food Safety and Inspection Service Microbiology Laboratory Guidebook (MLG) and the U.S. Food and Drug Administration Bacteriological Analytical Manual (BAM) reference methods. Food matrixes (chicken carcass rinse, beef trim, and spinach) were inoculated with low levels of Salmonella spp. (0.2-2 CFU/test portion) to generate fractional positives (5-15) in 20 inoculated samples. Samples were enriched with SAS Enrichment medium and incubated at 42 +/- 1 degree C. Enrichments were tested directly and subjected to anti-Salmonella IMS prior to the SAS Molecular Tests. Results were determined via visual fluorescence and via turbidity using a turbidimeter. All replicates were confirmed using the MLG or BAM reference method procedures, regardless of presumptive result. The SAS Molecular Tests Salmonella Detection modified methods were determined to be equivalent to the reference methods for the detection of Salmonella in chicken carcass rinse, beef trim, and fresh spinach. The inclusion of IMS in the modified method improved the detection rate of Salmonella in chicken carcass rinses and spinach. The optional use of visual fluorescent reagent and heat block either with IMS or without IMS produced results that were comparable to the results obtained from using a real-time turbidimeter.

  2. Learning SAS’s Perl Regular Expression Matching the Easy Way: By Doing

    Science.gov (United States)

    2015-01-12

    Regular Expression ( PRX ) functions were added in SAS9. The key to learning how to use them is learning PRX metacharacter behavior within a PRX match. The...more you practice PRX matching, the more proficient you become. Ideally, practice would involve a method for repeating the matching process so as to...regex_learning_tool allows both beginner and expert to efficiently practice PRX matching by selecting and processing only the match records that the user is interested

  3. Poisson回归模型的SAS GENMOD实现方法

    Institute of Scientific and Technical Information of China (English)

    孟小平

    2000-01-01

    通过实例演示了Poisson回归模型的SAS程序实现方法,采用SAS GENMOD过程进行Poisson回归分析,结果齐全、应用灵活,为服从Poisson分布的队列、随访等频数资料提供了有力的分析工具.

  4. Recent results of X-ray observations from OSO-7 and SAS-3

    Science.gov (United States)

    Clark, G. W.

    1978-01-01

    Recent observations bearing on the nature of compact X-ray sources obtained from the MIT instruments aboard OSO-7 and SAS-3 are discussed. Results on the X-ray sky survey, new ultralow-energy X-ray sources, X-ray sources in globular clusters, slow X-ray pulsars, and variability and position of compact X-ray sources in Cen A are discussed. Descriptions of the satellite-borne X-ray instruments are provided.

  5. SAS-3 observations of an X-ray flare from Cygnus X-1

    Science.gov (United States)

    Canizares, C. R.; Bradt, H.; Buff, J.; Laufer, B.

    1976-01-01

    Preliminary results are presented for the SAS-3 observation of an X-ray flare from Cygnus X-1. The 1.5 to 6 keV intensity rose by a factor of four and exhibited variability on several time scales from seconds to hours. The 6 to 15 keV intensity showed less activity. The event is similar to that observed by ANS and Ariel 5, but lasted less than two weeks.

  6. SAS统计分析软件模块揽要%Profiles on Modules of SAS

    Institute of Scientific and Technical Information of China (English)

    黄伟; 黄瑜

    2008-01-01

    SAS(Statistics Analysis System)是20世纪60年代初美国SAS公司研发的统计分析软件.SAS与SPSS及BMDP并称为国际上最有知名度的三大统计软件,如今,在我国社会科学乃至自然科学领域已得到了广泛应用.

  7. The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition.

    Science.gov (United States)

    Yamamoto, Masatoshi; Ohsawa, Shizue; Kunimasa, Kei; Igaki, Tatsushi

    2017-02-09

    Normal epithelial cells often exert anti-tumour effects against nearby oncogenic cells. In the Drosophila imaginal epithelium, clones of oncogenic cells with loss-of-function mutations in the apico-basal polarity genes scribble or discs large are actively eliminated by cell competition when surrounded by wild-type cells. Although c-Jun N-terminal kinase (JNK) signalling plays a crucial role in this cell elimination, the initial event, which occurs at the interface between normal cells and polarity-deficient cells, has not previously been identified. Here, through a genetic screen in Drosophila, we identify the ligand Sas and the receptor-type tyrosine phosphatase PTP10D as the cell-surface ligand-receptor system that drives tumour-suppressive cell competition. At the interface between the wild-type 'winner' and the polarity-deficient 'loser' clones, winner cells relocalize Sas to the lateral cell surface, whereas loser cells relocalize PTP10D there. This leads to the trans-activation of Sas-PTP10D signalling in loser cells, which restrains EGFR signalling and thereby enables elevated JNK signalling in loser cells, triggering cell elimination. In the absence of Sas-PTP10D, elevated EGFR signalling in loser cells switches the role of JNK from pro-apoptotic to pro-proliferative by inactivating the Hippo pathway, thereby driving the overgrowth of polarity-deficient cells. These findings uncover the mechanism by which normal epithelial cells recognize oncogenic polarity-deficient neighbours to drive cell competition.

  8. Solubilization of the poorly water soluble drug, telmisartan, using supercritical anti-solvent (SAS) process.

    Science.gov (United States)

    Park, Junsung; Cho, Wonkyung; Cha, Kwang-Ho; Ahn, Junhyun; Han, Kang; Hwang, Sung-Joo

    2013-01-30

    Telmisartan is a biopharmaceutical classification system (BCS) class II drug that has extremely low water solubility but is freely soluble in highly alkalized solutions. Few organic solvents can dissolve telmisartan. This solubility problem is the main obstacle achieving the desired bioavailability. Because of its unique characteristics, the supercritical anti-solvent (SAS) process was used to BCS class II drug in a variety of ways including micronization, amorphization and solid dispersion. Solid dispersions were prepared using hydroxypropylmethylcellulose/polyvinylpyrrolidone (HPMC/PVP) at 1:0.5, 1:1, and 1:2 weight ratios of drug to polymer, and pure telmisartan was also treated using the SAS process. Processed samples were characterized for morphology, particle size, crystallinity, solubility, dissolution rate and polymorphic stability. After the SAS process, all samples were converted to the amorphous form and were confirmed to be hundreds nm in size. Solubility and dissolution rate were increased compared to the raw material. Solubility tended to increase with increases in the amount of polymer used. However, unlike the solubility results, the dissolution rate decreased with increases in polymer concentration due to gel layer formation of the polymer. Processed pure telmisartan showed the best drug release even though it had lower solubility compared to other solid dispersions; however, because there were no stabilizers in processed pure telmisartan, it recrystallized after 1 month under severe conditions, while the other solid dispersion samples remained amorphous form. We conclude that after controlling the formulation of solid dispersion, the SAS process could be a promising approach for improving the solubility and dissolution rate of telmisartan.

  9. Cosmic radiation and airline pilots. Exposure patterns of Norwegian SAS-pilots 1960 to 1994

    Energy Technology Data Exchange (ETDEWEB)

    Tveten, U.

    1997-02-01

    The work which is presented in this report is part of a Norwegian epidemiological project, carried out in cooperation between Institutt for Energiteknikk (IFE), the Norwegian Cancer Registry (NCR) and the Norwegian Radiation Protection Authority (NRPA). The project has been partially financed by the Norwegian Research Council. Originating from the Norwegian project, a number of similar projects have been started or are in the planning stage in a number of European countries. The present report lays the ground for estimation of individual exposure histories to cosmic radiation of pilots employed by the Scandinavian Airline System (SAS). The results presented in this report (radiation doserates for the different types of aircraft in the different years) will, in a later stage of the project, be utilized to estimate the individual radiation exposure histories. The major sources of information used as basis for this work is the collection of old SAS time tables found in the SAS Museum at Fornebu Airport in Oslo, and information provided by members of the Pilots Associations.

  10. Adaptation and Validation of the Sexual Assertiveness Scale (SAS) in a Sample of Male Drug Users.

    Science.gov (United States)

    Vallejo-Medina, Pablo; Sierra, Juan Carlos

    2015-04-21

    The aim of the present study was to adapt and validate the Sexual Assertiveness Scale (SAS) in a sample of male drug users. A sample of 326 male drug users and 322 non-clinical males was selected by cluster sampling and convenience sampling, respectively. Results showed that the scale had good psychometric properties and adequate internal consistency reliability (Initiation = .66, Refusal = .74 and STD-P = .79). An evaluation of the invariance showed strong factor equivalence between both samples. A high and moderate effect of Differential Item Functioning was only found in items 1 and 14 (∆R 2 Nagelkerke = .076 and .037, respectively). We strongly recommend not using item 1 if the goal is to compare the scores of both groups, otherwise the comparison will be biased. Correlations obtained between the CSFQ-14 and the safe sex ratio and the SAS subscales were significant (CI = 95%) and indicated good concurrent validity. Scores of male drug users were similar to those of non-clinical males. Therefore, the adaptation of the SAS to drug users provides enough guarantees for reliable and valid use in both clinical practice and research, although care should be taken with item 1.

  11. Living Together v. Living Well Together: A Normative Examination of the SAS Case

    Directory of Open Access Journals (Sweden)

    Lori G. Beaman

    2016-04-01

    Full Text Available The European Court of Human Rights decision in SAS from France illustrates how a policy and national mantra that ostensibly aims to enhance inclusiveness, ‘living together’, is legally deployed in a manner that may have the opposite effect. In essence, despite acknowledging the sincerity of SAS’s religious practice of wearing the niqab, and her agency in making the decision to do so, the Court focuses on radicalism and women’s oppression amongst Muslims. Taking the notion of living together as the beginning point, the paper explores the normative assumptions underlying this notion as illustrated in the judgment of the Court. An alternative approach, drawing on the work of Derrida for the notion of ‘living well together’ will be proposed and its implications for social inclusion explicated. The paper’s aim is to move beyond the specific example of SAS and France to argue that the SAS pattern of identifying particular values as ‘national values’, the deployment of those values through law, policy and public discourse, and their exclusionary effects is playing out in a number of Western democracies, including Canada, the country with which the author is most familiar. Because of this widespread dissemination of values and their framing as representative of who ‘we’ are, there is a pressing need to consider the potentially alienating effects of a specific manifestation of ‘living together’ and an alternative model of ‘living well together’.

  12. Embedding SAS approach into conjugate gradient algorithms for asymmetric 3D elasticity problems

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Hsin-Chu; Warsi, N.A. [Clark Atlanta Univ., GA (United States); Sameh, A. [Univ. of Minnesota, Minneapolis, MN (United States)

    1996-12-31

    In this paper, we present two strategies to embed the SAS (symmetric-and-antisymmetric) scheme into conjugate gradient (CG) algorithms to make solving 3D elasticity problems, with or without global reflexive symmetry, more efficient. The SAS approach is physically a domain decomposition scheme that takes advantage of reflexive symmetry of discretized physical problems, and algebraically a matrix transformation method that exploits special reflexivity properties of the matrix resulting from discretization. In addition to offering large-grain parallelism, which is valuable in a multiprocessing environment, the SAS scheme also has the potential for reducing arithmetic operations in the numerical solution of a reasonably wide class of scientific and engineering problems. This approach can be applied directly to problems that have global reflexive symmetry, yielding smaller and independent subproblems to solve, or indirectly to problems with partial symmetry, resulting in loosely coupled subproblems. The decomposition is achieved by separating the reflexive subspace from the antireflexive one, possessed by a special class of matrices A, A {element_of} C{sup n x n} that satisfy the relation A = PAP where P is a reflection matrix (symmetric signed permutation matrix).

  13. [Perioperative management in children with sleep apnea syndrome (SAS) undergoing adenoidotonsillectomy].

    Science.gov (United States)

    Mizuno, Ju; Nemoto, Mikiko; Sato, Tomoko; Yokoyama, Takeshi; Hanaoka, Kazuo

    2013-02-01

    We should take care of the occurrences of apnea and hypopnea after emergence from general anesthesia in the children with sleep apnea syndrome (SAS) due to an increase in sensitivity to opioid agonists given for previous recurrent hypoxia. Preoperative assessment for SAS with apnea hypopnea index (AHI), oxygen desaturation index (ODI), and minimum artery oxygen saturation by pulse oxymetry (lowest SpO2) obtained from polysomnography (PSG) test could help to predict the postoperative respiratory depression. In perioperative management in the children with SAS who are candidates for adenotonsillectomy, the dose of opioid agonists during anesthesia maintenance for purpose of postoperative analgesia and sedation should be reduced; postoperative respiratory and circulatory management with monitoring of respiratory movement of the thoracoabdominal part, and electrographic (ECG) and SpO2 monitoring should be continued intensively under long-term oxygen administration; and airway management, nasal continuous positive airway pressure (nCPAP), and artificial ventilation should be prepared for the occurrence of postoperative respiratory depression.

  14. PSHREG: a SAS macro for proportional and nonproportional subdistribution hazards regression.

    Science.gov (United States)

    Kohl, Maria; Plischke, Max; Leffondré, Karen; Heinze, Georg

    2015-02-01

    We present a new SAS macro %pshreg that can be used to fit a proportional subdistribution hazards model for survival data subject to competing risks. Our macro first modifies the input data set appropriately and then applies SAS's standard Cox regression procedure, PROC PHREG, using weights and counting-process style of specifying survival times to the modified data set. The modified data set can also be used to estimate cumulative incidence curves for the event of interest. The application of PROC PHREG has several advantages, e.g., it directly enables the user to apply the Firth correction, which has been proposed as a solution to the problem of undefined (infinite) maximum likelihood estimates in Cox regression, frequently encountered in small sample analyses. Deviation from proportional subdistribution hazards can be detected by both inspecting Schoenfeld-type residuals and testing correlation of these residuals with time, or by including interactions of covariates with functions of time. We illustrate application of these extended methods for competing risk regression using our macro, which is freely available at: http://cemsiis.meduniwien.ac.at/en/kb/science-research/software/statistical-software/pshreg, by means of analysis of a real chronic kidney disease study. We discuss differences in features and capabilities of %pshreg and the recent (January 2014) SAS PROC PHREG implementation of proportional subdistribution hazards modelling.

  15. [Perioperative management of an obese patient complicated with sleep apnea syndrome (SAS) undergoing awake craniotomy].

    Science.gov (United States)

    Komayama, Noriaki; Kamata, Kotoe; Maruyama, Takashi; Nitta, Masayuki; Muragaki, Yoshihiro; Ozaki, Makoto

    2014-10-01

    Both obesity (BMI over 30) and SAS are risks for Supper airway maintenance. We report an obese patient (BMI 33.5) with SAS who underwent awake craniotomy. Weight reduction was instructed 1 month before the operation, and the patient lost enough weight to use intraoperative MRI. Under general anesthesia, surgical pads containing 2% lidocaine with adrenaline were inserted into the nasal cavities. The patient's airway S was secured by i-gel® until dura was opened. A nasal airway was then inserted to confirm the upper airway patency and anesthetics were terminated The patient regained consciousness and started respiration. The i-gel® was removed. The nasal airway was changed to an RAE tracheal tube ; the tube was fixed above the vocal cords under bronchofiberscopic observation. Continuous positive airway pressure (CPAP) via RAE tube was started. Neither coughing nor epistaxis was observed.The RAE tube prevented glossoptosis and did not disturb speech mapping. Emergent endotracheal intubation was easily managed because the tube was close to the glottis. The RAE tube was removed and nasal CP AP was applied overnight Carefully prepared CP AP support via nasal RAE tube was practical in keeping upper airway patency for an obese patient complicated with SAS undergoing awake craniotomy.

  16. 基于SAS-WEBLOGIC的数据挖掘模型及应用%Data mining model and application based on SAS-weblogic

    Institute of Scientific and Technical Information of China (English)

    宋丽红

    2009-01-01

    提出了一种基于SAS-Weblogic的数据挖掘模型,SAS作为数据挖掘语言处于模型的核心,Weblogic作为中间构件,负责SAS数据集联系前端浏览器和后台数据库,起着监控和管理作用.该模型适用于大中型数据挖掘应用,为现代企业提供了一种重要的决策支持系统模型.最后通过实验证明了模型的有效性.

  17. Usual Dietary Intakes: SAS Macros for Estimating Ratios of Two Dietary Components that are Consumed Nearly Every Day

    Science.gov (United States)

    The following SAS macros can be used to create a bivariate distribution of usual intake of two dietary components that are consumed nearly every day and to calculate percentiles of the population distribution of the ratio of usual intakes.

  18. Repositioning the substrate activity screening (SAS) approach as a fragment-based method for identification of weak binders.

    Science.gov (United States)

    Gladysz, Rafaela; Cleenewerck, Matthias; Joossens, Jurgen; Lambeir, Anne-Marie; Augustyns, Koen; Van der Veken, Pieter

    2014-10-13

    Fragment-based drug discovery (FBDD) has evolved into an established approach for "hit" identification. Typically, most applications of FBDD depend on specialised cost- and time-intensive biophysical techniques. The substrate activity screening (SAS) approach has been proposed as a relatively cheap and straightforward alternative for identification of fragments for enzyme inhibitors. We have investigated SAS for the discovery of inhibitors of oncology target urokinase (uPA). Although our results support the key hypotheses of SAS, we also encountered a number of unreported limitations. In response, we propose an efficient modified methodology: "MSAS" (modified substrate activity screening). MSAS circumvents the limitations of SAS and broadens its scope by providing additional fragments and more coherent SAR data. As well as presenting and validating MSAS, this study expands existing SAR knowledge for the S1 pocket of uPA and reports new reversible and irreversible uPA inhibitor scaffolds.

  19. De novo centriole formation in human cells is error-prone and does not require SAS-6 self-assembly.

    Science.gov (United States)

    Wang, Won-Jing; Acehan, Devrim; Kao, Chien-Han; Jane, Wann-Neng; Uryu, Kunihiro; Tsou, Meng-Fu Bryan

    2015-11-26

    Vertebrate centrioles normally propagate through duplication, but in the absence of preexisting centrioles, de novo synthesis can occur. Consistently, centriole formation is thought to strictly rely on self-assembly, involving self-oligomerization of the centriolar protein SAS-6. Here, through reconstitution of de novo synthesis in human cells, we surprisingly found that normal looking centrioles capable of duplication and ciliation can arise in the absence of SAS-6 self-oligomerization. Moreover, whereas canonically duplicated centrioles always form correctly, de novo centrioles are prone to structural errors, even in the presence of SAS-6 self-oligomerization. These results indicate that centriole biogenesis does not strictly depend on SAS-6 self-assembly, and may require preexisting centrioles to ensure structural accuracy, fundamentally deviating from the current paradigm.

  20. Validation of SCALE (SAS2H) Isotopic Predictions for BWR Spent Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Hermann, O.W.

    1998-01-01

    Thirty spent fuel samples obtained from boiling-water-reactor (BWR) fuel pins have been modeled at Oak Ridge National Laboratory using the SAS2H sequence of the SCALE code system. The SAS2H sequence uses transport methods combined with the depletion and decay capabilities of the ORIGEN-S code to estimate the isotopic composition of fuel as a function of its burnup history. Results of these calculations are compared with chemical assay measurements of spent fuel inventories for each sample. Results show reasonable agreement between measured and predicted isotopic concentrations for important actinides; however, little data are available for most fission products considered to be important for spent fuel concerns (e.g., burnup credit, shielding, source-term calculations, etc.). This work is a follow-up to earlier works that studied the ability to predict spent fuel compositions in pressurized-water-reactor (PWR) fuel pins. Biases and uncertainties associated with BWR isotopic predictions are found to be larger than those of PWR calculations. Such behavior is expected, as the operation of a BWR is significantly more complex than that of a PWR plant, and in general the design of a BWR has a more heterogeneous configuration than that of a PWR. Nevertheless, this work shows that the simple models employed using SAS2H to represent such complexities result in agreement to within 5% (and often less than 1%) or less for most nuclides important for spent fuel applications. On the other hand, however, the set of fuel samples analyzed represent a small subset of the BWR fuel population, and results reported herein may not be representative of the full population of BWR spent fuel.

  1. Validation of SCALE (SAS2H) isotopic predictions for BWR spent fuel

    Energy Technology Data Exchange (ETDEWEB)

    Hermann, O.W.; DeHart, M.D.

    1998-09-01

    Thirty spent fuel samples obtained from boiling-water-reactor (BWR) fuel pins have been modeled at Oak Ridge National Laboratory using the SAS2H sequence of the SCALE code system. The SAS2H sequence uses transport methods combined with the depletion and decay capabilities of the ORIGEN-S code to estimate the isotopic composition of fuel as a function of its burnup history. Results of these calculations are compared with chemical assay measurements of spent fuel inventories for each sample. Results show reasonable agreement between measured and predicted isotopic concentrations for important actinides; however, little data are available for most fission products considered to be important for spent fuel concerns (e.g., burnup credit, shielding, source-term calculations, etc.). This work is a follow-up to earlier works that studied the ability to predict spent fuel compositions in pressurized-water-reactor (PWR) fuel pins. Biases and uncertainties associated with BWR isotopic predictions are found to be larger than those of PWR calculations. Such behavior is expected, as the operation of a BWR is significantly more complex than that of a PWR plant, and in general the design of a BWR has a more heterogeneous configuration than that of a PWR. Nevertheless, this work shows that the simple models employed using SAS2H to represent such complexities result in agreement to within 5% (and often less than 1%) or less for most nuclides important for spent fuel applications. On the other hand, however, the set of fuel samples analyzed represent a small subset of the BWR fuel population, and results reported herein may not be representative of the full population of BWR spent fuel.

  2. Handling missing data in cluster randomized trials: A demonstration of multiple imputation with PAN through SAS

    Directory of Open Access Journals (Sweden)

    Jiangxiu Zhou

    2014-09-01

    Full Text Available The purpose of this study is to demonstrate a way of dealing with missing data in clustered randomized trials by doing multiple imputation (MI with the PAN package in R through SAS. The procedure for doing MI with PAN through SAS is demonstrated in detail in order for researchers to be able to use this procedure with their own data. An illustration of the technique with empirical data was also included. In this illustration thePAN results were compared with pairwise deletion and three types of MI: (1 Normal Model (NM-MI ignoring the cluster structure; (2 NM-MI with dummy-coded cluster variables (fixed cluster structure; and (3 a hybrid NM-MI which imputes half the time ignoring the cluster structure, and the other half including the dummy-coded cluster variables. The empirical analysis showed that using PAN and the other strategies produced comparable parameter estimates. However, the dummy-coded MI overestimated the intraclass correlation, whereas MI ignoring the cluster structure and the hybrid MI underestimated the intraclass correlation. When compared with PAN, the p-value and standard error for the treatment effect were higher with dummy-coded MI, and lower with MI ignoring the clusterstructure, the hybrid MI approach, and pairwise deletion. Previous studies have shown that NM-MI is not appropriate for handling missing data in clustered randomized trials. This approach, in addition to the pairwise deletion approach, leads to a biased intraclass correlation and faultystatistical conclusions. Imputation in clustered randomized trials should be performed with PAN. We have demonstrated an easy way for using PAN through SAS.

  3. SAS molecular tests Escherichia coli O157 detection kit. Performance tested method 031203.

    Science.gov (United States)

    Bapanpally, Chandra; Montier, Laura; Khan, Shah; Kasra, Akif; Brunelle, Sharon L

    2014-01-01

    The SAS Molecular tests Escherichia coli O157 Detection method, a loop-mediated isothermal amplification method, performed as well as or better than the U.S. Department of Agriculture, Food Safety Inspection Service Microbiology Laboratory Guidebook and the U.S. Food and Drug Administration Bacteriological Analytical Manual reference methods for ground beef, beef trim, bagged mixed lettuce, and fresh spinach. Ground beef (30% fat, 25 g test portion) was validated for 7-8 h enrichment, leafy greens were validated in a 6-7 h enrichment, and ground beef (30% fat, 375 g composite test portion) and beef trim (375 g composite test portion) were validated in a 16-20 h enrichment. The method performance for meat and leafy green matrixes was also shown to be acceptable under conditions of co-enrichment with Salmonella. Thus, after a short co-enrichment step, ground beef, beef trim, lettuce, and spinach can be tested for both Salmonella and E. coli O157. The SAS Molecular tests Salmonella Detection Kit was validated using the same test portions as for the SAS Molecular tests E. coli O157 Detection Kit and those results are presented in a separate report. Inclusivity and exclusivity testing revealed no false negatives and no false positives among the 50 E. coli 0157 strains, including H7 and non-motile strains, and 30 non-E. coli O157 strains examined. Finally, the method was shown to be robust when variations to DNA extract hold time and DNA volume were varied. The method comparison and robustness data suggest a full 7 h enrichment time should be used for 25 g ground beef test portions.

  4. Human SAS-6 C-Terminus Nucleates and Promotes Microtubule Assembly in Vitro by Binding to Microtubules.

    Science.gov (United States)

    Gupta, Hindol; Badarudeen, Binshad; George, Athira; Thomas, Geethu Emily; Gireesh, K K; Manna, Tapas K

    2015-10-20

    Centrioles are essential components of the animal centrosome and play crucial roles in the formation of cilia and flagella. They are cylindrical structures composed of nine triplet microtubules organized around a central cartwheel. Recent studies have identified spindle assembly abnormal protein SAS-6 as a critical component necessary for formation of the cartwheel. However, the molecular details of how the cartwheel participates in centriolar microtubule assembly have not been clearly understood. In this report, we show that the C-terminal tail (residues 470-657) of human SAS-6, HsSAS-6 C, the region that has been shown to extend toward the centriolar wall where the microtubule triplets are organized, nucleated and induced microtubule polymerization in vitro. The N-terminus (residues 1-166) of HsSAS-6, the domain known to be involved in formation of the central hub of the cartwheel, did not, however, exert any effect on microtubule polymerization. HsSAS-6 C bound to the microtubules and localized along the lengths of the microtubules in vitro. Microtubule pull-down and coimmunoprecipitation (Co-IP) experiments with S-phase synchronized HeLa cell lysates showed that the endogenous HsSAS-6 coprecipitated with the microtubules, and it mediated interaction with tubulin. Isothermal calorimetry titration and size exclusion chromatography showed that HsSAS-6 C bound to the αβ-tubulin dimer in vitro. The results demonstrate that HsSAS-6 possesses an intrinsic microtubule assembly promoting activity and further implicate that its outer exposed C-terminal tail may play critical roles in microtubule assembly and stabilizing microtubule attachment with the centriolar cartwheel.

  5. Modelo de franquicia "Wico y Dass Pasteleritos S.A.S"

    OpenAIRE

    2013-01-01

    El modelo de franquicia para la empresa Wico Y Dass Pasteleritos S.A.S. se realizó con base a la investigación en torno al modelo de desarrollo de las franquicias tanto a nivel nacional como internacional, evidenciando en los grandes logros que han obtenido algunas empresas internacionales al aplicar el modelo franquiciario. En Colombia, los tipos de negociación basados en franquicias aún no se encuentran reglamentados por la jurisprudencia colombiana, por lo tanto, fue necesario guia...

  6. Café de la Montaña S.A.S

    OpenAIRE

    2013-01-01

    Crear la empresa Café de la Montaña S.A.S, para la implementación y sostenimiento de 27.500 árboles de café variedad castillo y producir 27.500 Kg de café pergamino seco de alta calidad en la finca La Estrella, vereda Buena Vista, municipio de Campo alegre departamento del Huila. El concepto innovador en este proyecto se encuentra en la implementación de un sistema agroforestal asociado al cultivo de café, además la implementación del modelo becolsub como alternativa para descontaminar los su...

  7. Adaptive Tests of Significance Using Permutations of Residuals with R and SAS

    CERN Document Server

    O'Gorman, Thomas W

    2012-01-01

    Provides the tools needed to successfully perform adaptive tests across a broad range of datasets Adaptive Tests of Significance Using Permutations of Residuals with R and SAS illustrates the power of adaptive tests and showcases their ability to adjust the testing method to suit a particular set of data. The book utilizes state-of-the-art software to demonstrate the practicality and benefits for data analysis in various fields of study. Beginning with an introduction, the book moves on to explore the underlying concepts of adaptive tests, including:Smoothing methods and normalizing transforma

  8. Generation of Synthetic SAS Data for Targets near the Seafloor: Propagation Component

    Science.gov (United States)

    2012-09-30

    ωωϕθω ωω srcijij it imin ti tj jmjn ti ij PFrr BAe rr BAeP ij       −        − =  , (1) where Psrc(ω) is the frequency... application and consists of the source and receiver locations rs and rr and a single image source located at rsi and image receiver at rri. This...range (provide the range meets the far field requirement). IMPACT/ APPLICATIONS The current version of SAS-ST has been used in comparisons with data

  9. %lrasch_mml: A SAS Macro for Marginal Maximum Likelihood Estimation in Longitudinal Polytomous Rasch Models

    Directory of Open Access Journals (Sweden)

    Maja Olsbjerg

    2015-10-01

    Full Text Available Item response theory models are often applied when a number items are used to measure a unidimensional latent variable. Originally proposed and used within educational research, they are also used when focus is on physical functioning or psychological wellbeing. Modern applications often need more general models, typically models for multidimensional latent variables or longitudinal models for repeated measurements. This paper describes a SAS macro that fits two-dimensional polytomous Rasch models using a specification of the model that is sufficiently flexible to accommodate longitudinal Rasch models. The macro estimates item parameters using marginal maximum likelihood estimation. A graphical presentation of item characteristic curves is included.

  10. %lrasch_mml: A SAS Macro for Marginal Maximum Likelihood Estimation in Longitudinal Polytomous Rasch Models

    Directory of Open Access Journals (Sweden)

    Maja Olsbjerg

    2015-10-01

    Full Text Available Item response theory models are often applied when a number items are used to measure a unidimensional latent variable. Originally proposed and used within educational research, they are also used when focus is on physical functioning or psychological wellbeing. Modern applications often need more general models, typically models for multidimensional latent variables or longitudinal models for repeated measurements. This paper describes a SAS macro that fits two-dimensional polytomous Rasch models using a specification of the model that is sufficiently flexible to accommodate longitudinal Rasch models. The macro estimates item parameters using marginal maximum likelihood estimation. A graphical presentation of item characteristic curves is included.

  11. SAS-2 observations of high energy gamma rays from discrete sources

    Science.gov (United States)

    Kniffen, D. A.; Fichtel, C. E.; Hartman, R. C.; Lamb, R. C.; Thompson, D. J.

    1977-01-01

    The SAS-2 identified six localized high energy (greater than 35 MeV) gamma ray sources. Four of these are the radio pulsars, PSR 0531+21, PSR 0833-45, PSR 1818-04, and PSR 1717-46 discovered in a search of 75 radio pulsars. The fact that only one of these is observed in X-rays, and the significant differences in pulse profiles in the gamma ray and radio observations, leads to the speculation that different mechanisms are involved.

  12. Gypenosides causes DNA damage and inhibits expression of DNA repair genes of human oral cancer SAS cells.

    Science.gov (United States)

    Lu, Kung-Wen; Chen, Jung-Chou; Lai, Tung-Yuan; Yang, Jai-Sing; Weng, Shu-Wen; Ma, Yi-Shih; Tang, Nou-Ying; Lu, Pei-Jung; Weng, Jing-Ru; Chung, Jing-Gung

    2010-01-01

    Gypenosides (Gyp) are the major components of Gynostemma pentaphyllum Makino, a Chinese medical plant. Recently, Gyp has been shown to induce cell cycle arrest and apoptosis in many human cancer cell lines. However, there is no available information to address the effects of Gyp on DNA damage and DNA repair-associated gene expression in human oral cancer cells. Therefore, we investigated whether Gyp induced DNA damage and DNA repair gene expression in human oral cancer SAS cells. The results from flow cytometric assay indicated that Gyp-induced cytotoxic effects led to a decrease in the percentage of viable SAS cells. The results from comet assay revealed that the incubation of SAS cells with Gyp led to a longer DNA migration smear (comet tail) when compared with control and this effect was dose-dependent. The results from real-time PCR analysis indicated that treatment of SAS cells with 180 mug/ml of Gyp for 24 h led to a decrease in 14-3-3sigma, DNA-dependent serine/threonine protein kinase (DNAPK), p53, ataxia telangiectasia mutated (ATM), ataxia-telangiectasia and Rad3-related (ATR) and breast cancer gene 1 (BRCA1) mRNA expression. These observations may explain the cell death caused by Gyp in SAS cells. Taken together, Gyp induced DNA damage and inhibited DNA repair-associated gene expressions in human oral cancer SAS cells in vitro.

  13. Detection of sasX gene in Staphylococcus aureus and molecular epidemiological characteristics%金黄色葡萄球菌sasX基因的检测及其分子流行特征

    Institute of Scientific and Technical Information of China (English)

    钟一鸣; 丁健生; 刘文恩; 李虹玲; 晏群; 刘清霞

    2016-01-01

    目的:调查医院金黄色葡萄球菌 sasX 基因的携带情况并探究其分子流行特征,为揭示该基因在本地区的流行状况提供依据。方法收集中南大学湘雅医院2012年1-12月临床分离鉴定的金黄色葡萄球菌128株,采用 PCR 检测 sasX 基因,对该基因阳性的菌株采用多重 PCR 检测 SCCmec 分型、PCR 扩增 pvl 毒素基因,并进行多位点序列分型(MLST )和葡萄球菌 A 蛋白序列分析。结果128株金黄色葡萄球菌中共检测出2株 sasX 基因阳性菌株,检出率为1.6%,经头孢西丁鉴定这2株菌株均为耐甲氧西林金黄色葡萄球菌(MRSA),SCCmec Ⅲ分型均为 SCCmec Ⅲ型,pv l 基因均阴性,MLST 分型为 ST239,spa 分型为 t037型。结论首次在湖南地区临床分离的金黄色葡萄球菌中发现存在 sasX 基因,sasX 基因可能是导致医院持续感染的毒力因素之一,应密切关注其流行发展趋势。%OBJECTIVE To investigate the prevalence of sasX gene in Staphylococcus aureus (S .aureus) strains and explore the molecular epidemiological characteristics so as to reveal the prevalence of the gene in this area . METHODS A total of 128 clinical S .aureus isolates were collected from Xiangya Hospital ,Central South Universi-ty from Jan 2012 to Dec 2012 ,then the sasX gene was detected by using PCR ,the SCCmec Ⅲ genotypes were de-tected for the sasX-positive strains with the use of multiple PCR ,the pvl toxin gene was amplified by PCR ,the multilocus sequence typing (MLST) was conducted to determine the sequence types(STs) ,and the staphylococcal protein A sequence typing (spa) of the sasX-positive strains was performed .RESULTS Of the 128 strains of S .au-reus ,2 were detected positive for the sasX gene ,with the detection rate 1 .6% ;both of the 2 strains were identi-fied as methicillin-resistant S .aureus (MRSA) by cefoxitin ,all of the SCCmec Ⅲ genotypes were SCCmec Ⅲ ,and the pvl gene was detected

  14. Social Anxiety Scale for Adolescents (SAS-A: Psychometric properties in a Spanish-speaking population

    Directory of Open Access Journals (Sweden)

    José Olivares

    2005-01-01

    Full Text Available El objetivo de este estudio instrumental fue estudiar la estructura factorial y propiedades psicométricas de la Escala de Ansiedad Social para Adolescentes (SASA. Participaron 2407 adolescentes (1263 chicos y 1144 chicas, con una edad media de 15 años, alumnos de nueve institutos de la región de Murcia. Los resultados obtenidos apoyan la estructura tri-factorial propuesta por los autores de la escala (FNE, SAD-New, SAD-General. Se encontraron correlaciones interescalas significativas y niveles de consistencia interna elevados para las subescalas, así como respecto de los efectos del sexo en la puntuación SAS-A/Total y en sus subescalas, alcanzando las chicas las puntuaciones más elevadas. Sólo se hallaron diferencias significativas para la edad en la subescala FNE y no se constataron efectos de interacción entre los dos factores. Estos hallazgos parecen avalar el uso de la SAS-A en población adolescente de habla española.

  15. Preparation and Physicochemical Properties of 10-Hydroxycamptothecin (HCPT Nanoparticles by Supercritical Antisolvent (SAS Process

    Directory of Open Access Journals (Sweden)

    Baoyou Zhang

    2011-04-01

    Full Text Available The goal of the present work was to study the feasibility of 10-hydroxycamptothecin (HCPT nanoparticle preparation using supercritical antisolvent (SAS precipitation. The influences of various experimental factors on the mean particle size (MPS of HCPT nanoparticles were investigated. The optimum micronization conditions are determined as follows: HCPT solution concentration 0.5 mg/mL, the flow rate ratio of CO2 and HCPT solution 19.55, precipitation temperature 35 °C and precipitation pressure 20 MPa. Under the optimum conditions, HCPT nanoparticles with a MPS of 180 ± 20.3 nm were obtained. Moreover, the HCPT nanoparticles obtained were characterized by Scanning electron microscopy, Dynamic light scattering, Fourier-transform infrared spectroscopy, High performance liquid chromatography-mass spectrometry, X-ray diffraction and Differential scanning calorimetry analyses. The physicochemical characterization results showed that the SAS process had not induced degradation of HCPT. Finally, the dissolution rates of HCPT nanoparticles were investigated and the results proved that there is a significant increase in dissolution rate compared to unprocessed HCPT.

  16. Krāsas un atmosfēra Edgara Alana Po dzejā

    OpenAIRE

    Kļimova, Kristīna

    2009-01-01

    Bakalaura darba tēma ir krāsas un noskaņa Edgar Allana Po dzejā. Pētījuma uzdevums ir noteikt biežāk lietojamos tēlainās izteiksmes līdzekļus un krāsas Edgara Po dzejā, turklāt identificēt gaisotni un noskaņu šajos darbos. Darba autore ir veikusi pētījumu balstoties uz praktiskām un teorētiskām zināšanām. Teorētiskā daļa iztirzā tāda veida problēmas kā: tēlainās izteiksmes līdzekļu būtību, simbolu un simbolsisko krāsu izmantošana literatūrā, ka arī to nozīmi Edgara Allana Po dzejā, un cit...

  17. MLGA: A SAS Macro to Compute Maximum Likelihood Estimators via Genetic Algorithms

    Directory of Open Access Journals (Sweden)

    Francisco Juretig

    2015-08-01

    Full Text Available Nonlinear regression is usually implemented in SAS either by using PROC NLIN or PROC NLMIXED. Apart from the model structure, initial values need to be specified for each parameter. And after some convergence criteria are fulfilled, the second order conditions need to be analyzed. But numerical problems are expected to appear in case the likelihood is nearly discontinuous, has plateaus, multiple maxima, or the initial values are distant from the true parameter estimates. The usual solution consists of using a grid, and then choosing the set of parameters reporting the highest log-likelihood. However, if the amount of parameters or grid points is large, the computational burden will be excessive. Furthermore, there is no guarantee that, as the number of grid points increases, an equal or better set of points will be found. Genetic algorithms can overcome these problems by replicating how nature optimizes its processes. The MLGA macro is presented; it solves a maximum likelihood estimation problem under normality through PROC GA, and the resulting values can later be used as the starting values in SAS nonlinear procedures. As will be demonstrated, this macro can avoid the usual trial and error approach that is needed when convergence problems arise. Finally, it will be shown how this macro can deal with complicated restrictions involving multiple parameters.

  18. Efficiency prediction for a low head bulb turbine with SAS SST and zonal LES turbulence models

    Science.gov (United States)

    Jošt, D.; Škerlavaj, A.

    2014-03-01

    A comparison between results of numerical simulations and measurements for a 3-blade bulb turbine is presented in order to determine an appropriate numerical setup for accurate and reliable simulations of flow in low head turbines. Numerical analysis was done for three angles of runner blades at two values of head. For the smallest blade angle the efficiency was quite accurately predicted, but for the optimal and maximal blade angles steady state analysis entirely failed to predict the efficiency due to underestimated torque on the shaft and incorrect results in the draft tube. Transient simulation with SST did not give satisfactory results, but with SAS and zonal LES models the prediction of efficiency was significantly improved. From the results obtained by SAS and zonal LES the interdependence between turbulence models, vortex structures in the flow, values of eddy viscosity and flow energy losses in the draft tube can be seen. Also the effect of using the bounded central differential scheme instead of the high resolution scheme was evident. To test the effect of grid density, simulations were performed on four grids. While a difference between results obtained on the basic grid and on the fine grid was small, the results obtained on the coarse grids were not satisfactory.

  19. Comparing the importance of prognostic factors in Cox and logistic regression using SAS.

    Science.gov (United States)

    Heinze, Georg; Schemper, Michael

    2003-06-01

    Two SAS macro programs are presented that evaluate the relative importance of prognostic factors in the proportional hazards regression model and in the logistic regression model. The importance of a prognostic factor is quantified by the proportion of variation in the outcome attributable to this factor. For proportional hazards regression, the program %RELIMPCR uses the recently proposed measure V to calculate the proportion of explained variation (PEV). For the logistic model, the R(2) measure based on squared raw residuals is used by the program %RELIMPLR. Both programs are able to compute marginal and partial PEV, to compare PEVs of factors, of groups of factors, and even to compare PEVs of different models. The programs use a bootstrap resampling scheme to test differences of the PEVs of different factors. Confidence limits for P-values are provided. The programs further allow to base the computation of PEV on models with shrinked or bias-corrected parameter estimates. The SAS macros are freely available at www.akh-wien.ac.at/imc/biometrie/relimp

  20. Final SAS-2 gamma ray results on sources in the galactic anticenter region

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Hartman, R. C.; Kniffen, D. A.; Lamb, R. C.

    1976-01-01

    Analysis of SAS-2 high energy Gamma ray data from the direction of the galactic anticenter shows that this region is characterized by: a diffuse emission from the galactic plane which has a maximum along b=0 deg and an enhancement toward negative latitudes associated with Gould's Belt, a strong point source in the direction of the Crab nebula, and a second intense localized source near galactic coordinates 195 deg, +5 deg. Gamma ray emission from the Crab source is dominated by a pulsed flux from PSR 0531+21. The total flux above 100MeV is 3.7 + or - 0.8 million/sq cm s. The source near 195 deg, + 5 deg has a flux above 100 MeV of 4.3 + or - 0.9 million/sq cm s. Its spectrum appears flatter than that of the Crab. The diffuse galactic plane emission at negative lattitudes shows a general correlation with the local matter distribution associated with Gould's Belt. The calculated Gamma ray intensity agrees well with the SAS-2 observations.

  1. Effects of 2D and 3D Error Fields on the SAS Divertor Magnetic Topology

    Science.gov (United States)

    Trevisan, G. L.; Lao, L. L.; Strait, E. J.; Guo, H. Y.; Wu, W.; Evans, T. E.

    2016-10-01

    The successful design of plasma-facing components in fusion experiments is of paramount importance in both the operation of future reactors and in the modification of operating machines. Indeed, the Small Angle Slot (SAS) divertor concept, proposed for application on the DIII-D experiment, combines a small incident angle at the plasma strike point with a progressively opening slot, so as to better control heat flux and erosion in high-performance tokamak plasmas. Uncertainty quantification of the error fields expected around the striking point provides additional useful information in both the design and the modeling phases of the new divertor, in part due to the particular geometric requirement of the striking flux surfaces. The presented work involves both 2D and 3D magnetic error field analysis on the SAS strike point carried out using the EFIT code for 2D equilibrium reconstruction, V3POST for vacuum 3D computations and the OMFIT integrated modeling framework for data analysis. An uncertainty in the magnetic probes' signals is found to propagate non-linearly as an uncertainty in the striking point and angle, which can be quantified through statistical analysis to yield robust estimates. Work supported by contracts DE-FG02-95ER54309 and DE-FC02-04ER54698.

  2. Development and validation of logistic prognostic models by predefined SAS-macros

    Directory of Open Access Journals (Sweden)

    Ziegler, Christoph

    2006-02-01

    Full Text Available In medical decision making about therapies or diagnostic procedures in the treatment of patients the prognoses of the course or of the magnitude of diseases plays a relevant role. Beside of the subjective attitude of the clinician mathematical models can help in providing such prognoses. Such models are mostly multivariate regression models. In the case of a dichotomous outcome the logistic model will be applied as the standard model. In this paper we will describe SAS-macros for the development of such a model, for examination of the prognostic performance, and for model validation. The rational for this developmental approach of a prognostic modelling and the description of the macros can only given briefly in this paper. Much more details are given in. These 14 SAS-macros are a tool for setting up the whole process of deriving a prognostic model. Especially the possibility of validating the model by a standardized software tool gives an opportunity, which is not used in general in published prognostic models. Therefore, this can help to develop new models with good prognostic performance for use in medical applications.

  3. [Use of the anatomical cemented femoral stem SAS I: mid-term results].

    Science.gov (United States)

    Mikláš, M; Pink, M; Valoušek, T

    2015-01-01

    PURPOSE OF THE STUDY In view of increasing interest in a relationship between the surface of an implant and its behaviour and longevity in total hip arthroplasty (THA), the aim of this study is to present the clinical and radiographic results, as well as complications, of hip replacement surgery using the cemented femoral stem SAS I. MATERIAL AND METHODS A total of 298 cemented femoral stems SAS I were implanted in 275 patients at our department between 1996 and 2005. The patient average age was 72.1 years, with the range from 64 to 92 years. The pre-operative diagnoses were as follows: primary osteoarthritis in 179 (30.1%); post-dysplastic osteoarthritis in 41 (13.7%); femoral neck fracture in 44 (14.8%); avascular necrosis of the femoral head in 23 (7.7%); rheumatoid arthritis in nine (3%) and other causes in two (0.7%) patients. Of the 275 patients who had the surgery, 186 (204 THAs) underwent clinical and X-ray examination at an average follow-up of 11.5 years (range, 8 to 17 years). The clinical results were used to calculate the Harris hip score and radiographic evaluation was based on antero-posterior views. RESULTS The group of 186 assessed patients (204 THAs) comprised 106 women and 80 men, who were on average 85.4 years old on evaluation (range, 72 to 92 years). Of the remaining patients, 62 patients (64 THAs) died from causes unrelated to the surgery and 27 patients (30 THAs) were lost to follow-up. The functional outcome of surgery assessed by the Harris hip score was excellent in 61 (32.8%), good in 94 (50.5%), satisfactory in 26 (14%) and poor in five (2.7%) patients. The 93.1% SAS I stem longevity was recorded in relation to aseptic loosening; reimplantation for this indication was performed in 14 THAs. No revision surgery for failure due to valgus/varus deviations of the stem was carried out. Of the 204 hips, 188 had femoral stems aligned in neutral, 12 (5.9%) in valgus and four (2%) in varus positions. DISCUSSION The anatomical femoral stem SAS I

  4. The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies.

    Science.gov (United States)

    Cottee, Matthew A; Muschalik, Nadine; Johnson, Steven; Leveson, Joanna; Raff, Jordan W; Lea, Susan M

    2015-05-23

    Sas-6 and Ana2/STIL proteins are required for centriole duplication and the homo-oligomerisation properties of Sas-6 help establish the ninefold symmetry of the central cartwheel that initiates centriole assembly. Ana2/STIL proteins are poorly conserved, but they all contain a predicted Central Coiled-Coil Domain (CCCD). Here we show that the Drosophila Ana2 CCCD forms a tetramer, and we solve its structure to 0.8 Å, revealing that it adopts an unusual parallel-coil topology. We also solve the structure of the Drosophila Sas-6 N-terminal domain to 2.9 Å revealing that it forms higher-order oligomers through canonical interactions. Point mutations that perturb Sas-6 or Ana2 homo-oligomerisation in vitro strongly perturb centriole assembly in vivo. Thus, efficient centriole duplication in flies requires the homo-oligomerisation of both Sas-6 and Ana2, and the Ana2 CCCD tetramer structure provides important information on how these proteins might cooperate to form a cartwheel structure.

  5. Realization of data analysis system for Internet negotiation based on SAS/IntrNet%基于SAS/IntrNet的网上谈判数据分析系统的实现

    Institute of Scientific and Technical Information of China (English)

    冯玉强; 马兴辉

    2005-01-01

    针对SAS统计分析系统局限于单机应用的现状,提出了SAS与Web服务器相结合的方式来弥补SAS系统在Web环境下应用的不足,介绍了利用SAS/IntrNet实现SAS的Web应用的基本原理,给出了SAS/IntrNet程序处理的一般流程和相关配置文件的详细配置方法,解决了SAS/IntrNet系统实现中的几个关键问题.同时给出这一应用的具体实例--网上谈判数据分析系统的具体实现方法.

  6. GLUMIP 2.0: SAS/IML Software for Planning Internal Pilots

    Directory of Open Access Journals (Sweden)

    John A. Kairalla

    2008-09-01

    Full Text Available Internal pilot designs involve conducting interim power analysis (without interim data analysis to modify the final sample size. Recently developed techniques have been described to avoid the type~I error rate inflation inherent to unadjusted hypothesis tests, while still providing the advantages of an internal pilot design. We present GLUMIP 2.0, the latest version of our free SAS/IML software for planning internal pilot studies in the general linear univariate model (GLUM framework. The new analytic forms incorporated into the updated software solve many problems inherent to current internal pilot techniques for linear models with Gaussian errors. Hence, the GLUMIP 2.0 software makes it easy to perform exact power analysis for internal pilots under the GLUM framework with independent Gaussian errors and fixed predictors.

  7. Computational procedures for probing interactions in OLS and logistic regression: SPSS and SAS implementations.

    Science.gov (United States)

    Hayes, Andrew F; Matthes, Jörg

    2009-08-01

    Researchers often hypothesize moderated effects, in which the effect of an independent variable on an outcome variable depends on the value of a moderator variable. Such an effect reveals itself statistically as an interaction between the independent and moderator variables in a model of the outcome variable. When an interaction is found, it is important to probe the interaction, for theories and hypotheses often predict not just interaction but a specific pattern of effects of the focal independent variable as a function of the moderator. This article describes the familiar pick-a-point approach and the much less familiar Johnson-Neyman technique for probing interactions in linear models and introduces macros for SPSS and SAS to simplify the computations and facilitate the probing of interactions in ordinary least squares and logistic regression. A script version of the SPSS macro is also available for users who prefer a point-and-click user interface rather than command syntax.

  8. Estimation of the concordance correlation coefficient for repeated measures using SAS and R.

    Science.gov (United States)

    Carrasco, Josep L; Phillips, Brenda R; Puig-Martinez, Josep; King, Tonya S; Chinchilli, Vernon M

    2013-03-01

    The concordance correlation coefficient is one of the most common approaches used to assess agreement among different observers or instruments when the outcome of interest is a continuous variable. A SAS macro and R package are provided here to estimate the concordance correlation coefficient (CCC) where the design of the data involves repeated measurements by subject and observer. The CCC is estimated using U-statistics (UST) and variance components (VC) approaches. Confidence intervals and standard errors are reported along with the point estimate of the CCC. In the case of the VC approach, the linear mixed model output and variance components estimates are also provided. The performance of each function is shown by means of some examples with real data sets.

  9. Valoración de empresa Haceb Whirpool Industrial S.A.S.

    OpenAIRE

    Giraldo Cardona, Juan Camilo

    2015-01-01

    Este trabajo presenta la valoración de la empresa Haceb Whirlpool Industrial S.A.S. -- En la primera sección se describe la situación en estudio a través de la presentación de la empresa, una breve reseña histórica de cada uno de los accionistas, información del mercado de electrodomésticos en Colombia (especialmente la relacionada con el mercado de lavadoras), también se describe qué es un Joint Venture y por último la pertinencia de la valoración para los órganos de dirección -- En la segun...

  10. [Calculating Pearson residual in logistic regressions: a comparison between SPSS and SAS].

    Science.gov (United States)

    Xu, Hao; Zhang, Tao; Li, Xiao-song; Liu, Yuan-yuan

    2015-01-01

    To compare the results of Pearson residual calculations in logistic regression models using SPSS and SAS. We reviewed Pearson residual calculation methods, and used two sets of data to test logistic models constructed by SPSS and STATA. One model contained a small number of covariates compared to the number of observed. The other contained a similar number of covariates as the number of observed. The two software packages produced similar Pearson residual estimates when the models contained a similar number of covariates as the number of observed, but the results differed when the number of observed was much greater than the number of covariates. The two software packages produce different results of Pearson residuals, especially when the models contain a small number of covariates. Further studies are warranted.

  11. Plan estratégico para la empresa A.L Telecomunicaciones S.A.S

    OpenAIRE

    Martínez Ascencio, Nohra Alejandra; Fonseca Torrijos, Camila Andrea

    2016-01-01

    El presente trabajo está constituido por cinco capítulos en los que se desarrolla el plan estratégico para la empresa A.L Telecomunicaciones S.A.S. El primer capítulo expone los antecedentes de la compañía y por qué se hace necesaria la elaboración del plan estratégico para el nuevo negocio de la empresa. En el segundo capítulo se elabora la fundamentación teórica, donde se describe la importancia de la planeación estratégica y el direccionamiento estratégico y los conceptos fundamental...

  12. SAS-2 observations of the high energy gamma radiation from the Vela region

    Science.gov (United States)

    Thompson, D. J.; Bignami, G. F.; Fichtel, C. E.; Kniffen, D. A.

    1974-01-01

    Data from a scan of the galactic plane by the SAS-B high energy gamma ray experiment in the region 250 deg smaller than 12 smaller than 290 deg show a statistically significant excess over the general radiation from the galactic plane for gamma radiation of energy larger than 100 MeV. If the enhanced gamma radiation results from interactions of cosmic rays with galactic matter, as the energy spectrum suggests, it seems reasonable to associate the enhancement with large scale galactic features, such as spiral arm segments in that direction, or with the region surrounding the Vela supernova remnant with which PSR 0833-45 is associated. If the excess is attributed to cosmic rays released from the supernova interacting with the interstellar matter in that region, than on the order of 3 x 10 to the 50th power ergs would have been released by that supernova in the form of cosmic rays.

  13. McSAS: A package for extracting quantitative form-free distributions

    CERN Document Server

    Breßler, Ingo; Thünemann, Andreas

    2014-01-01

    A reliable and user-friendly characterisation of nano-objects in a target material is presented here in the form of a software data analysis package for interpreting small-angle X-ray scattering (SAXS) patterns. When provided with data on absolute scale with reasonable uncertainty estimates, the software outputs (size) distributions in absolute volume fractions complete with uncertainty estimates and minimum evidence limits, and outputs all distribution modes of a user definable range of one or more model parameters. A multitude of models are included, including prolate and oblate nanoparticles, core-shell objects, polymer models (Gaussian chain and Kholodenko worm) and a model for densely packed spheres (using the LMA-PY approximations). The McSAS software can furthermore be integrated as part of an automated reduction and analysis procedure in laboratory instruments or at synchrotron beamlines.

  14. The dental X-ray file of crew members in the Scandinavian Airlines System (SAS).

    Science.gov (United States)

    Keiser-Nielsen, S; Johanson, G; Solheim, T

    1981-11-01

    In 1977, the Scandinavian Airlines System (SAS) established a dental X-ray file of all crew members. Its aim was to have immediately available an adequate set of physical antemortem data useful for identification in case of a fatal crash. Recently, an investigation into the quality and suitability of this material was carried out. The radiographs of 100 Danish, 100 Norwegian, and 100 Swedish pilots were picked at random and evaluated for formal deficiences, technical deficiencies, treatment pattern as useful for identification purposes, and the presence of pathology. The major results of the investigation were that a number of formal and technical deficiencies were disclosed, that the treatment pattern would seem adequate for identification purposes, and that a number of pathological findings were made, several of which had to be considered possible safety risks in the form of barodontalgia.

  15. SAS-2 high-energy gamma-ray observations of the Vela pulsar

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Kniffen, D. A.; Ogelman, H. B.

    1975-01-01

    The Second Small Astronomy Satellite (SAS-2) high-energy (in excess of 35 MeV) gamma-ray telescope has detected pulsed gamma-ray emission at the radio period from PSR 0833-45, the Vela pulsar, as well as an unpulsed flux from the Vela region. The pulsed emission consists of two peaks following the single radio peak by about 13 ms and 48 ms. The luminosity of the pulsed emission above 100 MeV from Vela is about 0.1 that of the pulsar NP 0532 in the Crab nebula, whereas the pulsed emission from Vela at optical wavelengths is less than 0.0002 that from the Crab. The relatively high intensity of the pulsed gamma-ray emission, and the double peak structure, compared with the single pulse in the radio emission, suggest that the high-energy gamma-ray pulsar emission may be produced under different conditions from those at lower energies.

  16. SAS-2 observations of gamma rays from the galactic plane. [noting longitude and latitude observation

    Science.gov (United States)

    Thompson, D. J.; Bignami, G. F.; Fichtel, C. E.; Hartman, R. C.; Kniffen, D. A.

    1974-01-01

    Preliminary data are given for the SAS-2 high energy galactic gamma ray observation. These data include both latitude and longitude distributions. The longitude distribution shows a high density region. The latitude distributions toward the center and the anti-center are markedly different, the former showing a two-component structure of half-widths of approximately 3 and 6 deg. The energy spectrum in the range 35 to 200 MeV is hard, consistent with cosmic ray interactions with interstellar matter, including neutral pions decay and emission from energetic electron interactions. The data is consistent with an interpretation in terms of the confinement of the cosmic rays in the spiral arms.

  17. Final SAS-2 gamma-ray results on sources in the galactic anticenter region

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Hartman, R. C.; Kniffen, D. A.; Lamb, R. C.

    1977-01-01

    Final results are presented for SAS-2 observations of high-energy gamma-rays from the galactic anticenter region. Three main gamma-ray features are shown to characterize this region: a localized source associated with the Crab Nebula and its pulsar, another localized source near galactic coordinates 195 deg, +5 deg, and a general enhancement of the diffuse background 10 to 15 deg south of the galactic plane, which is associated with the Gould Belt. For the Crab, it is found that the radiation is mostly pulsed, the pulsed fraction increases with energy, and the intensity of the radiation in the main and interpulse peaks is approximately the same. The other localized source, provisionally designated as gamma 195+5, is found to have a harder spectrum than the Crab but no obvious radio counterpart; emission from an external galaxy is ruled out.

  18. SAS-2 gamma-ray observations of PSR 1747-46. [radio pulsar

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Kniffen, D. A.; Ogelman, H. B.; Lamb, R. C.

    1976-01-01

    Evidence is reported for the observation of gamma-ray emission from the radio pulsar PSR 1747-46 by the gamma-ray telescope aboard SAS 2. The evidence is based on the presence of both an approximately 3-sigma enhancement of gamma rays at the pulsar's location and an approximately 4-sigma peak in the phase plot of 79 gamma-ray events whose phase was calculated from the pulsar's known period. The gamma-ray pulsation is found to appear at a phase lag of about 0.16 from that predicted by the radio observations. The pulsed gamma-ray fluxes above 35 MeV and 100 MeV are estimated, and it is shown that the gamma-ray pulse width is similar to the radio pulse width. It is concluded that PSR 1747-46 is a most likely candidate for pulsed gamma-ray emission.

  19. Numerical Investigation of Pressure Fluctuation in Centrifugal Pump Volute Based on SAS Model and Experimental Validation

    Directory of Open Access Journals (Sweden)

    Qiaorui Si

    2014-02-01

    Full Text Available This paper presents an investigation of pressure fluctuation of a single-suction volute-type centrifugal pump, particularly volute casing, by using numerical and experimental methods. A new type of hybrid Reynolds-averaged Navier-Stokes/Large Eddy Simulation, referred to as the shear stress transport-scale-adaptive simulation (SAS model, is employed to study the unsteady flow. Statistical analysis method is adopted to show the pressure fluctuation intensity distribution in the volute channel. A test rig for pressure pulsation measurement is built to validate the numerical simulation results using eight transient pressure sensors in the middle section of the volute wall. Results show that the SAS model can accurately predict the inner flow field of centrifugal pumps. Radial force acting on the impeller presents a star distribution related to the blade number. Pressure fluctuation intensity is strongest near the tongue and shows irregular distribution in the pump casing. Pressure fluctuation is distributed symmetrically at the cross-section of the volute casing because the volute can eliminate the rotational movement of the liquid discharged from the impeller. Blade passing frequency and its multiples indicate the dominant frequency of the monitoring points within the volute, and the low-frequency pulsation, particularly in the shaft component, increases when it operates at off-design condition, particularly with a small flow rate. The reason is that the vortex wave is enhanced at the off-design condition, which has an effect on the axle and is presented in the shaft component in the frequency domain.

  20. Integrative Biological Chemistry Program Includes The Use Of Informatics Tools, GIS And SAS Software Applications.

    Science.gov (United States)

    D'Souza, Malcolm J; Kashmar, Richard J; Hurst, Kent; Fiedler, Frank; Gross, Catherine E; Deol, Jasbir K; Wilson, Alora

    Wesley College is a private, primarily undergraduate minority-serving institution located in the historic district of Dover, Delaware (DE). The College recently revised its baccalaureate biological chemistry program requirements to include a one-semester Physical Chemistry for the Life Sciences course and project-based experiential learning courses using instrumentation, data-collection, data-storage, statistical-modeling analysis, visualization, and computational techniques. In this revised curriculum, students begin with a traditional set of biology, chemistry, physics, and mathematics major core-requirements, a geographic information systems (GIS) course, a choice of an instrumental analysis course or a statistical analysis systems (SAS) programming course, and then, students can add major-electives that further add depth and value to their future post-graduate specialty areas. Open-sourced georeferenced census, health and health disparity data were coupled with GIS and SAS tools, in a public health surveillance system project, based on US county zip-codes, to develop use-cases for chronic adult obesity where income, poverty status, health insurance coverage, education, and age were categorical variables. Across the 48 contiguous states, obesity rates are found to be directly proportional to high poverty and inversely proportional to median income and educational achievement. For the State of Delaware, age and educational attainment were found to be limiting obesity risk-factors in its adult population. Furthermore, the 2004-2010 obesity trends showed that for two of the less densely populated Delaware counties; Sussex and Kent, the rates of adult obesity were found to be progressing at much higher proportions when compared to the national average.

  1. Proteomic analysis of cellular response induced by boron neutron capture reaction in human squamous cell carcinoma SAS cells.

    Science.gov (United States)

    Sato, Akira; Itoh, Tasuku; Imamichi, Shoji; Kikuhara, Sota; Fujimori, Hiroaki; Hirai, Takahisa; Saito, Soichiro; Sakurai, Yoshinori; Tanaka, Hiroki; Nakamura, Hiroyuki; Suzuki, Minoru; Murakami, Yasufumi; Baiseitov, Diaz; Berikkhanova, Kulzhan; Zhumadilov, Zhaxybay; Imahori, Yoshio; Itami, Jun; Ono, Koji; Masunaga, Shinichiro; Masutani, Mitsuko

    2015-12-01

    To understand the mechanism of cell death induced by boron neutron capture reaction (BNCR), we performed proteome analyses of human squamous tumor SAS cells after BNCR. Cells were irradiated with thermal neutron beam at KUR after incubation under boronophenylalanine (BPA)(+) and BPA(-) conditions. BNCR mainly induced typical apoptosis in SAS cells 24h post-irradiation. Proteomic analysis in SAS cells suggested that proteins functioning in endoplasmic reticulum, DNA repair, and RNA processing showed dynamic changes at early phase after BNCR and could be involved in the regulation of cellular response to BNCR. We found that the BNCR induces fragments of endoplasmic reticulum-localized lymphoid-restricted protein (LRMP). The fragmentation of LRMP was also observed in the rat tumor graft model 20 hours after BNCT treatment carried out at the National Nuclear Center of the Republic of Kazakhstan. These data suggest that dynamic changes of LRMP could be involved during cellular response to BNCR.

  2. Physicochemical properties and oral bioavailability of amorphous atorvastatin hemi-calcium using spray-drying and SAS process.

    Science.gov (United States)

    Kim, Jeong-Soo; Kim, Min-Soo; Park, Hee Jun; Jin, Shun-Ji; Lee, Sibeum; Hwang, Sung-Joo

    2008-07-09

    The objective of the study was to prepare amorphous atorvastatin hemi-calcium using spray-drying and supercritical antisolvent (SAS) process and evaluate its physicochemical properties and oral bioavailability. Atorvastatin hemi-calcium trihydrate was transformed to anhydrous amorphous form by spray-drying and SAS process. With the SAS process, the mean particle size and the specific surface area of amorphous atorvastatin were drastically changed to 68.7+/-15.8nm, 120.35+/-1.40m2/g and 95.7+/-12.2nm, 79.78+/-0.93m2/g from an acetone solution and a tetrahydrofuran solution, respectively and appeared to be associated with better performance in apparent solubility, dissolution and pharmacokinetic studies, compared with unprocessed crystalline atorvastatin. Oral AUC0-8h values in SD rats for crystalline and amorphous atorvastatin were as follow: 1121.4+/-212.0ngh/mL for crystalline atorvastatin, 3249.5+/-406.4ngh/mL and 3016.1+/-200.3ngh/mL for amorphous atorvastatin from an acetone solution and a tetrahydrofuran solution with SAS process, 2227.8+/-274.5 and 2099.9+/-339.2ngh/mL for amorphous atorvastatin from acetone and tetrahydrofuran with spray-drying. The AUCs of all amorphous atorvastatin significantly increased (PSAS process exhibits better bioavailability than spray-drying because of particle size reduction with narrow particle size distribution. It was concluded that physicochemical properties and bioavailability of crystalline atorvastatin could be improved by physical modification such as particle size reduction and generation of amorphous state using spray-drying and SAS process. Further, SAS process was a powerful methodology for improving the physicochemical properties and bioavailability of atorvastatin.

  3. ARP: Automatic rapid processing for the generation of problem dependent SAS2H/ORIGEN-s cross section libraries

    Energy Technology Data Exchange (ETDEWEB)

    Leal, L.C.; Hermann, O.W.; Bowman, S.M.; Parks, C.V.

    1998-04-01

    In this report, a methodology is described which serves as an alternative to the SAS2H path of the SCALE system to generate cross sections for point-depletion calculations with the ORIGEN-S code. ARP, Automatic Rapid Processing, is an algorithm that allows the generation of cross-section libraries suitable to the ORIGEN-S code by interpolation over pregenerated SAS2H libraries. The interpolations are carried out on the following variables: burnup, enrichment, and water density. The adequacy of the methodology is evaluated by comparing measured and computed spent fuel isotopic compositions for PWR and BWR systems.

  4. A leave-one-out cross-validation SAS macro for the identification of markers associated with survival.

    Science.gov (United States)

    Rushing, Christel; Bulusu, Anuradha; Hurwitz, Herbert I; Nixon, Andrew B; Pang, Herbert

    2015-02-01

    A proper internal validation is necessary for the development of a reliable and reproducible prognostic model for external validation. Variable selection is an important step for building prognostic models. However, not many existing approaches couple the ability to specify the number of covariates in the model with a cross-validation algorithm. We describe a user-friendly SAS macro that implements a score selection method and a leave-one-out cross-validation approach. We discuss the method and applications behind this algorithm, as well as details of the SAS macro.

  5. SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules.

    Science.gov (United States)

    Dammermann, Alexander; Maddox, Paul S; Desai, Arshad; Oegema, Karen

    2008-02-25

    Centrioles are surrounded by pericentriolar material (PCM), which is proposed to promote new centriole assembly by concentrating gamma-tubulin. Here, we quantitatively monitor new centriole assembly in living Caenorhabditis elegans embryos, focusing on the conserved components SAS-4 and SAS-6. We show that SAS-4 and SAS-6 are coordinately recruited to the site of new centriole assembly and reach their maximum levels during S phase. Centriolar SAS-6 is subsequently reduced by a mechanism intrinsic to the early assembly pathway that does not require progression into mitosis. Centriolar SAS-4 remains in dynamic equilibrium with the cytoplasmic pool until late prophase, when it is stably incorporated in a step that requires gamma-tubulin and microtubule assembly. These results indicate that gamma-tubulin in the PCM stabilizes the nascent daughter centriole by promoting microtubule addition to its outer wall. Such a mechanism may help restrict new centriole assembly to the vicinity of preexisting parent centrioles that recruit PCM.

  6. Design of a Road Friendly SAS System for Heavy-Duty Vehicles Based on a Fuzzy-Hybrid-ADD and GH-Control Strategy

    OpenAIRE

    Jing Zhao; Pak Kin Wong; Zhengchao Xie; Xinbo Ma; Caiyang Wei

    2016-01-01

    Semiactive suspension (SAS) system has been widely used for its outstanding performance in offering competent ride quality, road holding, and handling capacity. However, the road friendliness is also one of the crucial factors that should be attached in the design of the SAS system for heavy-duty vehicles. In this study, a fuzzy controlled hybrid-acceleration driven damper (ADD) and ground hook- (GH-) control strategy is proposed for SAS system of heavy-duty vehicles. Firstly, a quarter-vehic...

  7. Monoclonal Antibody Targeting Staphylococcus aureus Surface Protein A (SasA) Protect Against Staphylococcus aureus Sepsis and Peritonitis in Mice.

    Science.gov (United States)

    Yang, Yilong; Qian, Mengying; Yi, Shaoqiong; Liu, Shuling; Li, Bing; Yu, Rui; Guo, Qiang; Zhang, Xiaopeng; Yu, Changming; Li, Jianmin; Xu, Junjie; Chen, Wei

    2016-01-01

    Epidemic methicillin-resistant Staphylococcus aureus (MRSA) imposes an increasing impact on public health. Due to multi-antibiotics resistance in MRSA strains, there is an urgent need to develop novel therapeutics such as effective monoclonal antibodies (mAbs) against MRSA infections. Staphylococcus aureus surface protein A (SasA), a large surface-located protein (~240 kDa), is one of MSCRAMMs (microbial surface components recognizing adhesive matrix molecules) and a potential target for immunotherapeutic approaches against S. aureus infections. In the present study, we analyzed the sequence of SasA with bioinformatics tools and generated a protective monoclonal antibody (2H7) targeting the conserved domain of SasA. 2H7 was shown to recognize wild-type S. aureus and promote opsonophagocytic killing of S. aureus. In both sepsis and peritoneal infection models, prophylactic administration of 2H7 improved the survival of BALB/c mice challenged by S. aureus strain USA300 and ST239 (prevalent MRSA clones in North America and Asian countries, respectively) and enhanced bacterial clearance in kidneys. Additionally, 2H7 prophylaxis prevented the formation of intraperitoneal abscess in a murine model of peritoneal infection and therapeutic administration of 2H7 showed protective efficacy in a murine sepsis model. Our results presented here provide supporting evidences that an anti-SasA mAb might be a potential component in an antibody-based immunotherapeutic treatment of MRSA infections.

  8. SAS Code for Calculating Intraclass Correlation Coefficients and Effect Size Benchmarks for Site-Randomized Education Experiments

    Science.gov (United States)

    Brandon, Paul R.; Harrison, George M.; Lawton, Brian E.

    2013-01-01

    When evaluators plan site-randomized experiments, they must conduct the appropriate statistical power analyses. These analyses are most likely to be valid when they are based on data from the jurisdictions in which the studies are to be conducted. In this method note, we provide software code, in the form of a SAS macro, for producing statistical…

  9. Development and validation of the self-acceptance scale for persons with early blindness: the SAS-EB.

    Science.gov (United States)

    Morgado, Fabiane Frota da Rocha; Campana, Angela Nogueira Neves Betanho; Tavares, Maria da Consolação Gomes Cunha Fernandes

    2014-01-01

    Investigations of self-acceptance are critical to understanding the development and maintenance of psychological health. However, valid and reliable instruments for measuring self-acceptance in persons with early blindness have yet to be developed. The current research describes three studies designed to develop and validate the Self-acceptance Scale for Persons with Early Blindness (SAS-EB). In Study 1, we developed the initial item pool. Thirty-three items were generated, based on data from specialized literature and from 2 focus groups. Items were organized in a three-factor structure, theoretically predicted for SAS-EB - (1) body acceptance, (2) self-protection from social stigmas, and (3) feeling and believing in one's capacities. In Study 2, information obtained from a panel of 9 experts and 22 persons with early blindness representing the target population was used to refine the initial item pool, generating a new pool of 27 items. In Study 3, 318 persons with early blindness (141 women and 177 men), between 18 and 60 years of age (M = 37.74 years, SD = 12.37) answered the new pool of 27 items. After the elimination of 9 items using confirmatory factor analysis, we confirmed the theoretical three-factor structure of the SAS-EB. Study 3 also provided support for the scale's internal consistency and construct validity. Finally, the psychometric properties of the SAS-EB, its utility, and its limitations are discussed along with considerations for future research.

  10. An essential role of the basal body protein SAS-6 in Plasmodium male gamete development and malaria transmission.

    Science.gov (United States)

    Marques, Sara R; Ramakrishnan, Chandra; Carzaniga, Raffaella; Blagborough, Andrew M; Delves, Michael J; Talman, Arthur M; Sinden, Robert E

    2015-02-01

    Gametocytes are the sole Plasmodium parasite stages that infect mosquitoes; therefore development of functional gametes is required for malaria transmission. Flagellum assembly of the Plasmodium male gamete differs from that of most other eukaryotes in that it is intracytoplasmic but retains a key conserved feature: axonemes assemble from basal bodies. The centriole/basal body protein SAS-6 normally regulates assembly and duplication of these organelles and its depletion causes severe flagellar/ciliary abnormalities in a diverse array of eukaryotes. Since basal body and flagellum assembly are intimately coupled to male gamete development in Plasmodium, we hypothesized that SAS-6 disruption may cause gametogenesis defects and perturb transmission. We show that Plasmodium berghei sas6 knockouts display severely abnormal male gametogenesis presenting reduced basal body numbers, axonemal assembly defects and abnormal nuclear allocation. The defects in gametogenesis reduce fertilization and render Pbsas6 knockouts less infectious to mosquitoes. Additionally, we show that lack of Pbsas6 blocks transmission from mosquito to vertebrate host, revealing an additional yet undefined role in ookinete to sporulating oocysts transition. These findings underscore the vulnerability of the basal body/SAS-6 to malaria transmission blocking interventions.

  11. Integrating SAS and GIS software to improve habitat-use estimates from radiotelemetry data

    Science.gov (United States)

    Kenow, K.P.; Wright, R.G.; Samuel, M.D.; Rasmussen, P.W.

    2001-01-01

    Radiotelemetry has been used commonly to remotely determine habitat use by a variety of wildlife species. However, habitat misclassification can occur because the true location of a radiomarked animal can only be estimated. Analytical methods that provide improved estimates of habitat use from radiotelemetry location data using a subsampling approach have been proposed previously. We developed software, based on these methods, to conduct improved habitat-use analyses. A Statistical Analysis System (SAS)-executable file generates a random subsample of points from the error distribution of an estimated animal location and formats the output into ARC/INFO-compatible coordinate and attribute files. An associated ARC/INFO Arc Macro Language (AML) creates a coverage of the random points, determines the habitat type at each random point from an existing habitat coverage, sums the number of subsample points by habitat type for each location, and outputs tile results in ASCII format. The proportion and precision of habitat types used is calculated from the subsample of points generated for each radiotelemetry location. We illustrate the method and software by analysis of radiotelemetry data for a female wild turkey (Meleagris gallopavo).

  12. Acetyltransferase SAS2 and sirtuin SIR2, respectively, control flocculation and biofilm formation in wine yeast.

    Science.gov (United States)

    Rodriguez, María E; Orozco, Helena; Cantoral, Jesús M; Matallana, Emilia; Aranda, Agustín

    2014-09-01

    Cell-to-cell and cell-to-environment interactions of microorganisms are of substantial relevance for their biotechnological use. In the yeast Saccharomyces cerevisiae, flocculation can be an advantage to clarify final liquid products after fermentation, and biofilm formation may be relevant for the encapsulation of strains of interest. The adhesion properties of wine yeast strains can be modified by the genetic manipulation of transcriptional regulatory proteins, such as histone deacetylases, and acetylases. Sirtuin SIR2 is essential for the formation of mat structures, a kind of biofilm that requires the expression of cell-wall protein FLO11 as its deletion reduces FLO11 expression, and adhesion of cells to themselves and to agar in a commercial wine strain. Deletion of acetyltransferase GCN5 leads to a similar phenotype. A naturally flocculant wine yeast strain called P2 was characterized. Its flocculation happens only during grape juice fermentation and is due to the presence of a highly transcribed version of flocculin FLO5, linked to the presence of a δ sequence in the promoter. Deletion of acetyltransferase SAS2 enhances this phenotype and maltose fermentation even more. Therefore, the manipulation of acetylation/deacetylation machinery members is a valid way to alter the interaction of industrial yeast to their environment.

  13. Design of experiment and data analysis by JMP (SAS institute) in analytical method validation.

    Science.gov (United States)

    Ye, C; Liu, J; Ren, F; Okafo, N

    2000-08-15

    Validation of an analytical method through a series of experiments demonstrates that the method is suitable for its intended purpose. Due to multi-parameters to be examined and a large number of experiments involved in validation, it is important to design the experiments scientifically so that appropriate validation parameters can be examined simultaneously to provide a sound, overall knowledge of the capabilities of the analytical method. A statistical method through design of experiment (DOE) was applied to the validation of a HPLC analytical method for the quantitation of a small molecule in drug product in terms of intermediate precision and robustness study. The data were analyzed in JMP (SAS institute) software using analyses of variance method. Confidence intervals for outcomes and control limits for individual parameters were determined. It was demonstrated that the experimental design and statistical analysis used in this study provided an efficient and systematic approach to evaluating intermediate precision and robustness for a HPLC analytical method for small molecule quantitation.

  14. The ZpiM algorithm: a method for interferometric image reconstruction in SAR/SAS.

    Science.gov (United States)

    Dias, José M B; Leitao, José M N

    2002-01-01

    This paper presents an effective algorithm for absolute phase (not simply modulo-2-pi) estimation from incomplete, noisy and modulo-2pi observations in interferometric aperture radar and sonar (InSAR/InSAS). The adopted framework is also representative of other applications such as optical interferometry, magnetic resonance imaging and diffraction tomography. The Bayesian viewpoint is adopted; the observation density is 2-pi-periodic and accounts for the interferometric pair decorrelation and system noise; the a priori probability of the absolute phase is modeled by a compound Gauss-Markov random field (CGMRF) tailored to piecewise smooth absolute phase images. We propose an iterative scheme for the computation of the maximum a posteriori probability (MAP) absolute phase estimate. Each iteration embodies a discrete optimization step (Z-step), implemented by network programming techniques and an iterative conditional modes (ICM) step (pi-step). Accordingly, the algorithm is termed ZpiM, where the letter M stands for maximization. An important contribution of the paper is the simultaneous implementation of phase unwrapping (inference of the 2pi-multiples) and smoothing (denoising of the observations). This improves considerably the accuracy of the absolute phase estimates compared to methods in which the data is low-pass filtered prior to unwrapping. A set of experimental results, comparing the proposed algorithm with alternative methods, illustrates the effectiveness of our approach.

  15. Evaluation of sleep apnea syndrome (SAS) with low field MR fluoroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Fukatsu, Hiroshi; Ando, Yoko; Ishigaki, Takeo [Nagoya Univ. (Japan). School of Medicine; Okada, Tamotsu

    1995-02-01

    Eight cases of clinically diagnosed sleep apnea syndrome (SAS) and two normal volunteers were studied with low field MR fluoroscopy in order to monitor the waking and sleeping status of the upper airway. MR fluoroscopy revealed that only the sleeping patients showed occlusions of the upper airway. This technique provided us with useful information about the level, frequency and duration of occlusion in each case. Four of the eight patients demonstrated simple retropalatal occlusion, whereas the other four demonstrated mixed retropalatal and retropalato-retroglossal occlusion. Thus long-time monitoring, which is only possible with MR fluoroscopy, is needed to appreciate the complex nature of the disease. In addition, the comfortable surroundings and low noise level provided by the low field enabled physiological study to be performed without any tranquilizers in most of the patients, which is again only possible with MR fluoroscopy. MR fluoroscopy may become a tool of great clinical value, providing much important information for disease evaluation and treatment selection. (author).

  16. SPSS and SAS procedures for estimating indirect effects in simple mediation models.

    Science.gov (United States)

    Preacher, Kristopher J; Hayes, Andrew F

    2004-11-01

    Researchers often conduct mediation analysis in order to indirectly assess the effect of a proposed cause on some outcome through a proposed mediator. The utility of mediation analysis stems from its ability to go beyond the merely descriptive to a more functional understanding of the relationships among variables. A necessary component of mediation is a statistically and practically significant indirect effect. Although mediation hypotheses are frequently explored in psychological research, formal significance tests of indirect effects are rarely conducted. After a brief overview of mediation, we argue the importance of directly testing the significance of indirect effects and provide SPSS and SAS macros that facilitate estimation of the indirect effect with a normal theory approach and a bootstrap approach to obtaining confidence intervals, as well as the traditional approach advocated by Baron and Kenny (1986). We hope that this discussion and the macros will enhance the frequency of formal mediation tests in the psychology literature. Electronic copies of these macros may be downloaded from the Psychonomic Society's Web archive at www.psychonomic.org/archive/.

  17. [Evaluation of the factorial and metric equivalence of the Sexual Assertiveness Scale (SAS) by sex].

    Science.gov (United States)

    Sierra, Juan Carlos; Santos-Iglesias, Pablo; Vallejo-Medina, Pablo

    2012-05-01

    Sexual assertiveness refers to the ability to initiate sexual activity, refuse unwanted sexual activity, and use contraceptive methods to avoid sexually transmitted diseases, developing healthy sexual behaviors. The Sexual Assertiveness Scale (SAS) assesses these three dimensions. The purpose of this study is to evaluate, using structural equation modeling and differential item functioning, the equivalence of the scale between men and women. Standard scores are also provided. A total of 4,034 participants from 21 Spanish provinces took part in the study. Quota sampling method was used. Results indicate a strict equivalent dimensionality of the Sexual Assertiveness Scale across sexes. One item was flagged by differential item functioning, although it does not affect the scale. Therefore, there is no significant bias in the scale when comparing across sexes. Standard scores show similar Initiation assertiveness scores for men and women, and higher scores on Refusal and Sexually Transmitted Disease Prevention for women. This scale can be used on men and women with sufficient psychometric guarantees.

  18. Cosmic radiation and airline pilots. Exposure patterns of Norwegian pilots flying aircraft not used by SAS

    Energy Technology Data Exchange (ETDEWEB)

    Tveten, U.

    1997-05-01

    The work which is presented in this report is part of a Norwegian epidemiological project, carried out in cooperation between Institutt for Energiteknikk (IFE), the Norwegian Cancer Registry (NCR) and the Norwegian Radiation Protection Authority (NRPA). The project has been partially financed by the Norwegian Research Council. Originating from the Norwegian project, a number of similar projects have been started or are in the planning stage in a number of European countries. The present report lays the ground for estimation of individual exposure histories to cosmic radiation of pilots flying a great diversity of different aircrafts. Aircrafts that appear in the time-tables of the Scandinavian Airline System (SAS) have been treated in an earlier report. The results presented in this report (radiation doserates for the different types of aircrafts in the different years) will, in a later stage of the project be utilized to estimate the individual radiation exposure histories. The major sources of information used as basis for the work in this report is information provided by several active pilots, members of the Pilots Associations, along with calculations performed using US Federal Aviation Administration`s computer code CARI-3N. 2 refs.

  19. SAS-2 observations of the galactic gamma radiation from the Vela region

    Science.gov (United States)

    Thompson, D. J.; Bignami, G. F.; Fichtel, C. E.; Kniffen, D. A.

    1974-01-01

    Data from a scan of the galactic plane by the SAS-2 high energy gamma ray experiment in the region 250 deg l2 290 deg show a statistically-significant excess over the general radiation from the galactic plane for gamma radiation of energy 100 MeV in the region 260 deg l2 270 deg and -7.5 deg b2 0 deg. If the enhanced gamma radiation results from interactions of cosmic rays with galactic matter, as the energy spectrum suggests, it seems reasonable to associate the enhancement with large scale galactic features, such as spiral arm segments in that direction, or with the region surrounding the Vela supernova remnant, with which PSR 0833-45 is associated. If the excess is attributed to cosmic rays released from this supernova interacting with the interstellar matter in that region, then on the order of 3.10 to the 50th power ergs would be released by that supernova in the form of cosmic rays.

  20. Age-related changes in the bone marrow and spleen of SAS/4 mice.

    Science.gov (United States)

    Coggle, J E; Gordon, M Y; Proukakis, C; Bogg, C E

    1975-01-01

    The total number of nucleated cells in the bone marrow of SAS/4 mice increase some twofold between 1 and 24 months of age but when related to body weight remains essentially constant over a wide range of ages. The concentration of CFU-S in femoral marrow is also constant with age and since other bones containing marrow appear, at least in young mice, to have the same CFU-S concentration as the femur it is concluded that the CFU-S compartment size of the whole bone marrow is independent of age when expressed on a body weight basis, In contrast, both the absolute number and the concentration of exogenous CFU-S in the spleen decline markedly in old mice. Smilary there is a decline in the number of endogenous colony-forming cells and the spleens of 24-month-old mice seem virtually devoid of such colonies. Not only were older mice less capable of supporting the growth of endogenous colonies, but their spleens also appear to provide a poorer environment for exogenous colony growth when compared with growth in younger recipient spleens.

  1. SAS 3 observations of two X-ray transient events with precursors

    Science.gov (United States)

    Hoffman, J. A.; Lewin, W. H. G.; Doty, J.; Jernigan, J. G.; Haney, M.; Richardson, J. A.

    1978-01-01

    SAS 3 has observed two unusual fast transient X-ray events from different sources, one lasting about 150 s and one, approximately 1500 s. Both events were preceded by precursor pulses which lasted a few seconds and which rose and fell in less than 0.4 s. The precursors were separated from the 'main' events by several seconds, during which no X-rays were detected. There are similarities between the two main events and X-ray bursts in both their temporal and spectral evolution. The spectra of the main events started out much softer than the spectra of the precursors, became harder as they approached maximum intensity, and softened as they decayed. In the 1500-s event, X-rays with energies greater than 10 keV were delayed by about 80 s compared with 1.5-6-keV X-rays. A blackbody fit to the spectral data of the main event of approximately 1500-s duration gives a maximum temperature of 29 million K and a radius for the emitting region of at least about 9 km (at a distance of 10 kpc); this is similar to the temperature and sizes found for several X-ray burst sources.

  2. Sulfuric acid speleogenesis (SAS) close to the water table: Examples from southern France, Austria, and Sicily

    Science.gov (United States)

    De Waele, Jo; Audra, Philippe; Madonia, Giuliana; Vattano, Marco; Plan, Lukas; D'Angeli, Ilenia M.; Bigot, Jean-Yves; Anoux, Catherine; Nobécourt, Jean-Claude

    2016-01-01

    Caves formed by rising sulfuric waters have been described from all over the world in a wide variety of climate settings, from arid regions to mid-latitude and alpine areas. H2S is generally formed at depth by reduction of sulfates in the presence of hydrocarbons and is transported in solution through the deep aquifers. In tectonically disturbed areas major fractures eventually allow these H2S-bearing fluids to rise to the surface where oxidation processes can become active producing sulfuric acid. This extremely strong acid reacts with the carbonate bedrock creating caves, some of which are among the largest and most spectacular in the world. Production of sulfuric acid mostly occurs at or close to the water table but also in subaerial conditions in moisture films and droplets in the cave environment. These caves are generated at or immediately above the water table, where condensation-corrosion processes are dominant, creating a set of characteristic meso- and micromorphologies. Due to their close connection to the base level, these caves can also precisely record past hydrological and geomorphological settings. Certain authigenic cave minerals, produced during the sulfuric acid speleogenesis (SAS) phase, allow determination of the exact timing of speleogenesis. This paper deals with the morphological, geochemical and mineralogical description of four very typical sulfuric acid water table caves in Europe: the Grotte du Chat in the southern French Alps, the Acqua Fitusa Cave in Sicily (Italy), and the Bad Deutsch Altenburg and Kraushöhle caves in Austria.

  3. SAS-2 gamma-ray observations of PSR 1747-46

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Kniffen, D. A.; Lamb, R. C.; Oegelman, H. B.

    1976-01-01

    Observations with the SAS-2 high energy ( 35 MeV) gamma-ray telescope show evidence of gamma-ray emission from the radio pulsar PSR 1747-46. When the arrival times of gamma-rays from the region of the pulsar were converted to pulsar phases using the radio period and period derivative, a single peak was found in the phase plot, with a Poisson probability of occurring by chance of .00008. Independently, the time-averaged data for the PSR 1747-46 region show an enhancement over the surrounding region of the sky at the same galactic latitude, with a Poisson probability of chance occurrence of less than .008. The probability that these results are chance is the product of these two probabilities times the number of radio pulsars examined (73). This overall probability is sufficiently small (.00005) to suggest an identification of a new gamma-ray pulsar. In the gamma-ray pulsar plot, the peak falls 0.16 + or - 0.03 period after the radio pulsar peak. This phase shift is, within uncertainties, the same as that observed between the single radio peak and the first of the two gamma-ray peaks seen in the phase plot for PSR-0833-45 (the Vela pulsar).

  4. The School Anxiety Scale-Teacher Report (SAS-TR: translation and psychometric properties of the Iranian version

    Directory of Open Access Journals (Sweden)

    Hajiamini Zahra

    2012-07-01

    Full Text Available Abstract Background The School Anxiety Scale-Teacher Report (SAS-TR was designed to assess anxiety in children at school. The SAS-TR is a proxy rated measure and could assess social anxiety, generalized anxiety and also gives a total anxiety score. This study aimed to translate and validate the SAS-TR in Iran. Methods The translation and cultural adaptation of the original questionnaire were carried out in accordance with the published guidelines. A sample of students participated in the study. Reliability was estimated using internal consistency and test-retest analysis. Validity was assessed using content validity. The factor structure of the questionnaire was extracted by performing both exploratory and confirmatory factor analyses. Results In all 200 elementary students aged 6 to 10 years were studied. Considering the recommended cut-off values, overall the prevalence of high anxiety condition in elementary students was found to be 21 %. Cronbach's alpha coefficient for the Iranian SAS-TR was 0.92 and intraclass correlation coefficient (ICC was found to be 0.81. The principal component analysis indicated a two-factor structure for the questionnaire (generalized and social anxiety that jointly accounted for 55.3 % of variances observed. The confirmatory factory analysis also indicated a good fit to the data for the two-latent structure of the questionnaire. Conclusion In general the findings suggest that the Iranian version of SAS-TR has satisfactory reliability, and validity for measuring anxiety in 6 to 10 years old children in Iran. It is simple and easy to use and now can be applied in future studies.

  5. Comparison of ArcGIS and SAS Geostatistical Analyst to Estimate Population-Weighted Monthly Temperature for US Counties.

    Science.gov (United States)

    Xiaopeng, Q I; Liang, Wei; Barker, Laurie; Lekiachvili, Akaki; Xingyou, Zhang

    Temperature changes are known to have significant impacts on human health. Accurate estimates of population-weighted average monthly air temperature for US counties are needed to evaluate temperature's association with health behaviours and disease, which are sampled or reported at the county level and measured on a monthly-or 30-day-basis. Most reported temperature estimates were calculated using ArcGIS, relatively few used SAS. We compared the performance of geostatistical models to estimate population-weighted average temperature in each month for counties in 48 states using ArcGIS v9.3 and SAS v 9.2 on a CITGO platform. Monthly average temperature for Jan-Dec 2007 and elevation from 5435 weather stations were used to estimate the temperature at county population centroids. County estimates were produced with elevation as a covariate. Performance of models was assessed by comparing adjusted R(2), mean squared error, root mean squared error, and processing time. Prediction accuracy for split validation was above 90% for 11 months in ArcGIS and all 12 months in SAS. Cokriging in SAS achieved higher prediction accuracy and lower estimation bias as compared to cokriging in ArcGIS. County-level estimates produced by both packages were positively correlated (adjusted R(2) range=0.95 to 0.99); accuracy and precision improved with elevation as a covariate. Both methods from ArcGIS and SAS are reliable for U.S. county-level temperature estimates; However, ArcGIS's merits in spatial data pre-processing and processing time may be important considerations for software selection, especially for multi-year or multi-state projects.

  6. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT, PERFORMANCE TEST RESULTS FOR THE A AND A ENVIRONMENTAL SEALS' SEAL ASSIST SYSTEM (SAS), PHASE I--TECHNOLOGY VERIFICATION REPORT

    Science.gov (United States)

    The report presents results of tests determining the efficacy of A&A Environmental Seals, Inc's Seal Assist System (SAS) in preventing natural gas compressor station's compressor rod packing leaks from escaping into the atmosphere. The SAS consists of an Emission Containment Glan...

  7. RHESSI/SAS Observations of the Optical Solar Limb Over More Than 14 Years

    Science.gov (United States)

    Fivian, Martin; Hudson, Hugh S.; Krucker, Sam

    2016-05-01

    The Solar Aspect System (SAS) of the RHESSI satellite measures the optical solar limb with a cadence typically set at 100 samples/s.RHESSI has observed the Sun continuously since its launch in early 2002, and we have acquired a unique data set ranging over more than a full 11-year solar cycle and consisting of about 4x10^10 single data points.The optics has a point spread of about 4.5 arcsec FWHM imaging the red continuum onto three linear CCD sensors with a pixel resolution of 1.7 arcsec.However, careful study of systematics, masking of contaminated data, and accumulation of data over appropriate time intervals has led to measurementswith sub-milli arcsec accuracy.Analyzing data for an initial period in 2004, these measurements have led to the most accurate oblateness measurement to date, 8.01+-0.14 milli arcsec (Fivian et al., 2008), a value consistent with models predicting an oblateness from surface rotation.An excess oblateness term can be attributed to magnetic elements possibly located in the enhanced network.We also study photometric properties of our data. Previous observations of latitude-dependent brightness variations at the limb had suggested the presence of a polar temperature excess as large as 1.5 K.The RHESSI observations, made with a rotating telescope in space, have great advantages in the rejection of systematic errors in the very precise photometry required for such an observation.Our measurements of latitude-dependent brightness variations at the limb lead to a quadrupolar term (a pole-to-equator temperature variation) of the order of 0.1 K, an order of magnitude smaller than previously reported.We present the analysis of these unique data, an overview of some results and we report on our progress as we apply our developed analysis method to the whole 14 years of data.

  8. Cdk1 Phosphorylates Drosophila Sas-4 to Recruit Polo to Daughter Centrioles and Convert Them to Centrosomes.

    Science.gov (United States)

    Novak, Zsofia A; Wainman, Alan; Gartenmann, Lisa; Raff, Jordan W

    2016-06-20

    Centrosomes and cilia are organized by a centriole pair comprising an older mother and a younger daughter. Centriole numbers are tightly regulated, and daughter centrioles (which assemble in S phase) cannot themselves duplicate or organize centrosomes until they have passed through mitosis. It is unclear how this mitotic "centriole conversion" is regulated, but it requires Plk1/Polo kinase. Here we show that in flies, Cdk1 phosphorylates the conserved centriole protein Sas-4 during mitosis. This creates a Polo-docking site that helps recruit Polo to daughter centrioles and is required for the subsequent recruitment of Asterless (Asl), a protein essential for centriole duplication and mitotic centrosome assembly. Point mutations in Sas-4 that prevent Cdk1 phosphorylation or Polo docking do not block centriole disengagement during mitosis, but block efficient centriole conversion and lead to embryonic lethality. These observations can explain why daughter centrioles have to pass through mitosis before they can duplicate and organize a centrosome.

  9. An essential role of the basal body protein SAS-6 in Plasmodium male gamete development and malaria transmission

    OpenAIRE

    Marques, SR; Ramakrishnan, C; Carzaniga, R.; Blagborough, AM; Delves, MJ; Talman, AM; Sinden, RE

    2014-01-01

    Gametocytes are the sole P lasmodium parasite stages that infect mosquitoes; therefore development of functional gametes is required for malaria transmission. Flagellum assembly of the P lasmodium male gamete differs from that of most other eukaryotes in that it is intracytoplasmic but retains a key conserved feature: axonemes assemble from basal bodies. The centriole/basal body protein SAS-6 normally regulates assembly and duplication of these organelles and its depletion causes severe flage...

  10. Annotated Computer Output for Illustrative Examples of Clustering Using the Mixture Method and Two Comparable Methods from SAS.

    Science.gov (United States)

    1987-06-26

    BUREAU OF STANDAR-S1963-A Nw BOM -ILE COPY -. 4eo .?3sa.9"-,,A WIN* MAT HEMATICAL SCIENCES _*INSTITUTE AD-A184 687 DTICS!ELECTE ANNOTATED COMPUTER OUTPUT...intoduction to the use of mixture models in clustering. Cornell University Biometrics Unit Technical Report BU-920-M and Mathematical Sciences Institute...mixture method and two comparable methods from SAS. Cornell University Biometrics Unit Technical Report BU-921-M and Mathematical Sciences Institute

  11. Plan de negocios para la creación de la empresa Agua Vida S.A.S.

    OpenAIRE

    Del Rio Caicedo, Sergio Antonio; Rosero Morán, Daniel Hernando

    2013-01-01

    El trabajo contiene el plan de negocios para crear la empresa Agua Vida SAS., donde sus productos son la purificación y comercialización de agua potable en universidades mediante dispensadores; el documento presenta el plan de mercadeo y a su vez pretende despertar en los estudiantes conciencia ambiental para que carguen un termo y paguen para que este sea llenado en los dispensadores de las instituciones educativas

  12. Cosmic radiation and airline pilots. Exposure patterns of Norwegian SAS-pilots 1960 to 1994. Revised Version

    Energy Technology Data Exchange (ETDEWEB)

    Tveten, U

    1999-02-01

    The present report is a revised version of an earlier report (IFE/KR/E-96/008). The revision has been carried out since a completely new version of the computational tool has recently been released. All calculations have been redone. The work which is presented in this report is part of a Norwegian epidemiological project, carried out in cooperation between Institute for Energy Technology (IFE), the Norwegian Cancer Registry (NCR) and the Norwegian Radiation Protection Authority (NRPA). Originating from the Norwegian project, a number of similar projects have been started in a number of European countries. The present report lays the ground for estimation of individual exposure histories to cosmic radiation of pilots employed by the the Scandinavian Airlines System (SAS). The result presented in this report (radiation dose rates for the different types of aircraft in the different years) were calculated with the most recent computer program for this purpose, the CARI-5E from the United States Civil Aviation Authority. The other major sources of information used as basis for this work is the collection of old SAS time tables found the the SAS Museum at Fornebu Airport in Oslo, and information provided by members of the Pilots Association in Norway.

  13. Tutorial: Survival Estimation for Cox Regression Models with Time-Varying Coe?cients Using SAS and R

    Directory of Open Access Journals (Sweden)

    Laine Thomas

    2014-10-01

    Full Text Available Survival estimates are an essential compliment to multivariable regression models for time-to-event data, both for prediction and illustration of covariate effects. They are easily obtained under the Cox proportional-hazards model. In populations defined by an initial, acute event, like myocardial infarction, or in studies with long-term followup, the proportional-hazards assumption of constant hazard ratios is frequently violated. One alternative is to fit an interaction between covariates and a prespecified function of time, implemented as a time-dependent covariate. This effectively creates a time-varying coefficient that is easily estimated in software such as SAS and R. However, the usual programming statements for survival estimation are not directly applicable. Unique data manipulation and syntax is required, but is not well documented for either software. This paper offers a tutorial in survival estimation for the time-varying coefficient model, implemented in SAS and R. We provide a macro coxtvc to facilitate estimation in SAS where the current functionality is more limited. The macro is validated in simulated data and illustrated in an application.

  14. Cucurbitacin E as inducer of cell death and apoptosis in human oral squamous cell carcinoma cell line SAS.

    Science.gov (United States)

    Hung, Chao-Ming; Chang, Chi-Chang; Lin, Chen-Wei; Ko, Shun-Yao; Hsu, Yi-Chiang

    2013-08-20

    Human oral squamous cell carcinoma (OSCC) is a common form of malignant cancer, for which radiotherapy or chemotherapy are the main treatment methods. Cucurbitacin E (CuE) is a natural compound previously shown to be an antifeedant as well as a potent chemopreventive agent against several types of cancer. The present study investigates anti-proliferation (using MTT assay, CuE demonstrated cytotoxic activity against SAS cell with IC50 values at 3.69 µM) and induced apoptosis of human oral squamous cell carcinoma SAS cells after 24 h treatment with CuE. Mitochondrial membrane potential (MMP) and caspase activity were studied and our results indicate that CuE inhibits cell proliferation as well as the activation of apoptois in SAS cells. Both effects increased in proportion to the dosage of CuE and apoptosis was induced via mitochondria- and caspase-dependent pathways. CuE can induce cell death by a mechanism that is not dependent on apoptosis induction, and thus represents a promising anticancer agent for prevention and treatment of OSCC.

  15. Mexican Seismic Alert System's SAS-I algorithm review considering strong earthquakes felt in Mexico City since 1985

    Science.gov (United States)

    Cuellar Martinez, A.; Espinosa Aranda, J.; Suarez, G.; Ibarrola Alvarez, G.; Ramos Perez, S.; Camarillo Barranco, L.

    2013-05-01

    The Seismic Alert System of Mexico (SASMEX) uses three algorithms for alert activation that involve the distance between the seismic sensing field station (FS) and the city to be alerted; and the forecast for earthquake early warning activation in the cities integrated to the system, for example in Mexico City, the earthquakes occurred with the highest accelerations, were originated in the Pacific Ocean coast, whose distance this seismic region and the city, favors the use of algorithm called Algorithm SAS-I. This algorithm, without significant changes since its beginning in 1991, employs the data that generate one or more FS during P wave detection until S wave detection plus a period equal to the time employed to detect these phases; that is the double S-P time, called 2*(S-P). In this interval, the algorithm performs an integration process of quadratic samples from FS which uses a triaxial accelerometer to get two parameters: amplitude and growth rate measured until 2*(S-P) time. The parameters in SAS-I are used in a Magnitude classifier model, which was made from Guerrero Coast earthquakes time series, with reference to Mb magnitude mainly. This algorithm activates a Public or Preventive Alert if the model predicts whether Strong or Moderate earthquake. The SAS-I algorithm has been operating for over 23 years in the subduction zone of the Pacific Coast of Mexico, initially in Guerrero and followed by Oaxaca; and since March 2012 in the seismic region of Pacific covering the coasts among Jalisco, Colima, Michoacan, Guerrero and Oaxaca, where this algorithm has issued 16 Public Alert and 62 Preventive Alerts to the Mexico City where its soil conditions increase damages by earthquake such as the occurred in September 1985. This work shows the review of the SAS-I algorithm and possible alerts that it could generate from major earthquakes recordings detected by FS or seismometers near the earthquakes, coming from Pacific Ocean Coast whose have been felt in Mexico

  16. Tetrandrine induces cell death in SAS human oral cancer cells through caspase activation-dependent apoptosis and LC3-I and LC3-II activation-dependent autophagy.

    Science.gov (United States)

    Huang, An-Cheng; Lien, Jin-Cherng; Lin, Meng-Wei; Yang, Jai-Sing; Wu, Ping-Ping; Chang, Shu-Jen; Lai, Tung-Yuan

    2013-08-01

    Numerous studies have demonstrated that autophagy is associated with cancer development. Thus, agents to induce autophagy could be employed in some cases for the treatment of cancer. Our results showed that tetrandrine significantly decreased the viability of SAS cells in a concentration- and time-dependent manner. Tetrandrine induced nuclear condensation, demonstrated by DAPI staining. The early events in apoptosis analysed by Annexin V/PI staining indicated that the percentage of cells staining positive for Annexin V was slightly increased in SAS cells with tetrandrine treatment but was much lower following bafilomycin A1 pre-treatment. Tetrandrine caused AVO and MDC induction in SAS cells in a concentration-dependent manner by fluorescence microscopy. Tetrandrine also caused LC-3 expression in SAS cells in a time-dependent manner. Our results show that tetrandrine treatment induced the levels of cleaved caspase-3 in a concentration- and time-dependent manner. Tetrandrine treatment induced the levels of LC-3 II, Atg-5, beclin-1, p-S6, p-ULK, p-mTOR, p-Akt (S473) and raptor. Tetrandrine decreased cell viability, but bafilomycin A1, 3-MA, chloroquine and NAC protected tetrandrine-treated SAS cells against decrease of cell viability. Atg-5, beclin-1 siRNA decreased tetrandrine-induced cleaved caspase-3 and cleaved PARP in SAS cells and protected tetrandrine-treated SAS cells against decrease in cell viability. Chloroquine, NAC and bafilomycin A1 also decreased tetrandrine-induced cleaved caspase-3 and cleaved PARP in SAS cells. Our results indicate the tetrandrine induces apoptosis and autophagy of SAS human cancer cells via caspase-dependent and LC3-I and LC3-II‑dependent pathways.

  17. LSI的半高SAS RAID适配器满足了DSA环境下成本和空间的需求

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    LSI Logic公司近日宣布推出业内首批半高(low-profile.LP)SAS RAID存储适配器。新的MegaRAID SAS 8308ELP和SAS 8344ELP是具有8个SAS端口的PCI Express接口适配器,应用于需要使用3Gb/sSAS和/或SATA Ⅱ驱动器的服务器和工作站环境。

  18. Riik võib lüüa SAS-i esmaspäevaks Estonian Airi omanikeringist välja / Erik Müürsepp, Mikk Salu

    Index Scriptorium Estoniae

    Müürsepp, Erik

    2008-01-01

    SAS osaleb Estonian Airþile lisakapitali eraldamises ainult juhul, kui Eesti riik müüb oma osaluses lennukompaniis SAS-ile. Peaminister Andrus Ansipi ning majandus- ja kommunikatsiooniminister Juhan Partsi seisukoht

  19. Novel acridine-based N-acyl-homoserine lactone analogs induce endoreduplication in the human oral squamous carcinoma cell line SAS.

    Science.gov (United States)

    Chai, Hongbo; Hazawa, Masaharu; Hosokawa, Yoichiro; Igarashi, Jun; Suga, Hiroaki; Kashiwakura, Ikuo

    2012-01-01

    The cytotoxicity of novel acridine-based N-acyl-homoserine lactone (AHL) analogs was investigated on the human oral squamous carcinoma cell line SAS. One analog induced G2/M phase arrest at 5.3-10.6 µM and induced polyploidy at a higher dose (21.2 µM). Importantly, treatment of SAS cells with a combination of the AHL analog and the Jun N-terminal kinase (JNK) inhibitor, SP600125, prevented mitosis and induced polyploidy. The AHL analog synergized with X-irradiation to inhibit clonogenic survival of SAS cells; however, its radiosensitizing effects were relative to not X-irradiation-induced apoptosis but mitotic failure following enhanced expression of Aurora A and B. These results suggest that the active AHL analog showed growth-suppressive and radiosensitizing effects, which involve polyploidy followed by G2/M accumulation and atypical cell death in the SAS cell line.

  20. TD-LTE Test System Anite SAS Based on Anite 9000%基于AniteSAS的TD-LTE IOT测试系统开发

    Institute of Scientific and Technical Information of China (English)

    康亮; 李传峰; 秦方民; 崔斌

    2012-01-01

    this article makes an all-around introduction to SAS, the TD-LTE Test system based on Anite 9000. Firstly, the necessity and the contents of SAS Test system is introduced. Then, how to realize TD-LTE test in SAS system is presented detailedly. Finally, the advantage of SAS system is analyzed.%对基于Anite9000的SAS测试系统进行了全面的介绍。首先介绍了SAS测试的必要陛和基本内容,接着阐述了如何使用SAS测试系统实现TD—LTE的测试。最后对SAS的优点进行飞龠舐。

  1. The Music Therapy Session Assessment Scale (MT-SAS): Validation of a new tool for music therapy process evaluation.

    Science.gov (United States)

    Raglio, Alfredo; Gnesi, Marco; Monti, Maria Cristina; Oasi, Osmano; Gianotti, Marta; Attardo, Lapo; Gontero, Giulia; Morotti, Lara; Boffelli, Sara; Imbriani, Chiara; Montomoli, Cristina; Imbriani, Marcello

    2017-08-25

    Music therapy (MT) interventions are aimed at creating and developing a relationship between patient and therapist. However, there is a lack of validated observational instruments to consistently evaluate the MT process. The purpose of this study was the validation of Music Therapy Session Assessment Scale (MT-SAS), designed to assess the relationship between therapist and patient during active MT sessions. Videotapes of a single 30-min session per patient were considered. A pilot study on the videotapes of 10 patients was carried out to help refine the items, define the scoring system and improve inter-rater reliability among the five raters. Then, a validation study on 100 patients with different clinical conditions was carried out. The Italian MT-SAS was used throughout the process, although we also provide an English translation. The final scale consisted of 7 binary items accounting for eye contact, countenance, and nonverbal and sound-music communication. In the pilot study, raters were found to share an acceptable level of agreement in their assessments. Explorative factorial analysis disclosed a single homogeneous factor including 6 items (thus supporting an ordinal total score), with only the item about eye contact being unrelated to the others. Moreover, the existence of 2 different archetypal profiles of attuned and disattuned behaviours was highlighted through multiple correspondence analysis. As suggested by the consistent results of 2 different analyses, MT-SAS is a reliable tool that globally evaluates sonorous-musical and nonverbal behaviours related to emotional attunement and empathetic relationship between patient and therapist during active MT sessions. Copyright © 2017 John Wiley & Sons, Ltd.

  2. Phenethyl isothiocyanate suppresses EGF-stimulated SAS human oral squamous carcinoma cell invasion by targeting EGF receptor signaling.

    Science.gov (United States)

    Chen, Hui-Jye; Lin, Chung-Ming; Lee, Chao-Ying; Shih, Nai-Chen; Amagaya, Sakae; Lin, Yung-Chang; Yang, Jai-Sing

    2013-08-01

    Phenethyl isothiocyanate (PEITC) is a natural compound that is involved in chemoprevention as well as inhibition of cell growth and induction of apoptosis in several types of cancer cells. Previous studies have revealed that PEITC suppresses the invasion of AGS gastric and HT-29 colorectal cancer cells. However, the effects of PEITC on the metastasis of SAS oral cancer cells remain to be determined. Our results showed that PEITC treatment inhibited the invasion of EGF-stimulated SAS cells in a concentration-dependent manner, but appeared not to affect the cell viability. The expression and enzymatic activities of matrix metalloprotease-2 (MMP-2) and matrix metalloprotease-9 (MMP-9) were suppressed by PEITC. Concomitantly, we observed an increase in the protein expression of both tissue inhibitor of metalloproteinase-1 (TIMP-1) and -2 (TIMP-2) in treated cells. Furthermore, PEITC treatments decreased the protein phosphorylation of epidermal growth factor receptor (EGFR) and downstream signaling proteins including PDK1, PI3K (p85), AKT, phosphorylated IKK and IκB to inactivate NF-κB for the suppression of MMP-2 and MMP-9 expression. In addition, PEITC can trigger the MAPK signaling pathway through the increase in phosphorylated p38, JNK and ERK in treated cells. Our data indicate that PEITC is able to inhibit the invasion of EGF-stimulated SAS oral cancer cells by targeting EGFR and its downstream signaling molecules and finally lead to the reduced expression and enzymatic activities of both MMP-2 and MMP-9. These results suggest that PEITC is promising for the therapy of oral cancer metastasis.

  3. Atomistic modelling of scattering data in the Collaborative Computational Project for Small Angle Scattering (CCP-SAS).

    Science.gov (United States)

    Perkins, Stephen J; Wright, David W; Zhang, Hailiang; Brookes, Emre H; Chen, Jianhan; Irving, Thomas C; Krueger, Susan; Barlow, David J; Edler, Karen J; Scott, David J; Terrill, Nicholas J; King, Stephen M; Butler, Paul D; Curtis, Joseph E

    2016-12-01

    The capabilities of current computer simulations provide a unique opportunity to model small-angle scattering (SAS) data at the atomistic level, and to include other structural constraints ranging from molecular and atomistic energetics to crystallography, electron microscopy and NMR. This extends the capabilities of solution scattering and provides deeper insights into the physics and chemistry of the systems studied. Realizing this potential, however, requires integrating the experimental data with a new generation of modelling software. To achieve this, the CCP-SAS collaboration (http://www.ccpsas.org/) is developing open-source, high-throughput and user-friendly software for the atomistic and coarse-grained molecular modelling of scattering data. Robust state-of-the-art molecular simulation engines and molecular dynamics and Monte Carlo force fields provide constraints to the solution structure inferred from the small-angle scattering data, which incorporates the known physical chemistry of the system. The implementation of this software suite involves a tiered approach in which GenApp provides the deployment infrastructure for running applications on both standard and high-performance computing hardware, and SASSIE provides a workflow framework into which modules can be plugged to prepare structures, carry out simulations, calculate theoretical scattering data and compare results with experimental data. GenApp produces the accessible web-based front end termed SASSIE-web, and GenApp and SASSIE also make community SAS codes available. Applications are illustrated by case studies: (i) inter-domain flexibility in two- to six-domain proteins as exemplified by HIV-1 Gag, MASP and ubiquitin; (ii) the hinge conformation in human IgG2 and IgA1 antibodies; (iii) the complex formed between a hexameric protein Hfq and mRNA; and (iv) synthetic 'bottlebrush' polymers.

  4. Analysis of Correlates in SAS.SDS and MMPI of Stutters%口吃患者MMPI与SAS、SDS的相关分析

    Institute of Scientific and Technical Information of China (English)

    刘盈; 丁宝坤; 肖可畏; 石文惠; 李晓东; 王晓武; 孙晓敏

    2001-01-01

    Objective:To investigate the personality feature of stuttering. Methods: SAS, SDS, MMPI were administered to 108 patients with stuttering, 110 normal controls, 103 patients with OCD, 137 patients with depression. Results: The scores of F, K, D, Mf, Pa, Pt, Sc, Si in stuttering group were significantly differen from OCD and depression groups. The scores of SAS were positively correlated with the score of F, D, Ht, Pd, Pt, Sc, Si. Conclusion: The personality feature of stuttering were depressive and compulsive personality.

  5. ¿Cuáles son las consecuencias jurídicas de constituir una Sociedad por Acciones Simplificada (SAS) para hacer fraude a la ley?

    OpenAIRE

    Pinchao, Edith

    2015-01-01

    Abstract: The Sociedades por Acciones Simplificadas, commonly known as SAS, offer to their stockholders a kind of company with multiple economic and juridical benefits. Nevertheless, this has caused that some of these SAS have been created with the aim to do fraud or to harm third parties, i.e. they are constituted with illicit purposes. As a result, the limited responsibility of partners becomes unlimited and shared; removing corporate image from juridical person, a legal phenomenon named di...

  6. Escala de sociotropía-autonomía (SAS: propiedades psicométricas de la adaptación a Colombia

    Directory of Open Access Journals (Sweden)

    Ronald Alberto Toro Tobar

    2014-07-01

    Full Text Available Este artículo presenta los resultados de una investigación cuyo objetivo fue adaptar y validar la Escala de Sociotropía-Autonomía (SAS de Clark & Beck, la cual evalúa dos dimensiones de personalidad cognitiva: la orientación interpersonal y actitudes de logro y metas personales. La muestra consistió en 460 participantes entre 15 y 71 años, escolarizados de distintos estratos socioeconómicos. Los resultados mostraron índices de consistencia interna en la Escala SAS: total (,85, SAS Sociotropía (,82 y menores para SAS autonomía (,61. Estos resultados guardan relación con investigaciones acerca de este instrumento; por lo tanto se considera confiable y válido para el contexto sociocultural; además podría apoyar la investigación en psicoterapia cognitiva y en procesos clínicos basados en el modelo diátesis estrés. Abstract This paper presents the results of a study whose aim was adapt and validate the Sociotropy-Autonomy Scale (SAS Clark & Beck. This scale assesses two dimensions of cognitive personality: interpersonal orientation and attitudes of achievement and personal goals. The sample consisted of 460 participants between 15 and 71 years enrolled from different socioeconomic levels. The results showed internal consistency in SAS Scale: Total (.85, SAS Sociotropy (.82 and lower for SAS Autonomy (.61. These results are relevant to research on this instrument. It is considered a reliable and valid instrument for socio-cultural context; could also support research in cognitive psychotherapy and clinical processes based on the diathesis stress model.

  7. SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test.

    Science.gov (United States)

    O'Connor, B P

    2000-08-01

    Popular statistical software packages do not have the proper procedures for determining the number of components in factor and principal components analyses. Parallel analysis and Velicer's minimum average partial (MAP) test are validated procedures, recommended widely by statisticians. However, many researchers continue to use alternative, simpler, but flawed procedures, such as the eigenvalues-greater-than-one rule. Use of the proper procedures might be increased if these procedures could be conducted within familiar software environments. This paper describes brief and efficient programs for using SPSS and SAS to conduct parallel analyses and the MAP test.

  8. Exploring item and higher order factor structure with the Schmid-Leiman solution: syntax codes for SPSS and SAS.

    Science.gov (United States)

    Wolff, Hans-Georg; Preising, Katja

    2005-02-01

    To ease the interpretation of higher order factor analysis, the direct relationships between variables and higher order factors may be calculated by the Schmid-Leiman solution (SLS; Schmid & Leiman, 1957). This simple transformation of higher order factor analysis orthogonalizes first-order and higher order factors and thereby allows the interpretation of the relative impact of factor levels on variables. The Schmid-Leiman solution may also be used to facilitate theorizing and scale development. The rationale for the procedure is presented, supplemented by syntax codes for SPSS and SAS, since the transformation is not part of most statistical programs. Syntax codes may also be downloaded from www.psychonomic.org/archive/.

  9. SAS Enterprise Data Integration Server - A Complete Solution Designed To Meet the Full Spectrum of Enterprise Data Integration Needs

    Directory of Open Access Journals (Sweden)

    Silvia BOLOHAN

    2012-05-01

    Full Text Available This paper is about why is Data Integration important for organisations around the world. Organizations struggle daily with the challenges of large distributed data volumes, inconsistently defined data across disparate systems and the high expectations of data consumers who depend on information to be correct, complete and available when they need it. SAS Enterprise Data Integration Server provides a comprehensive solution that enables organizations to solve these challenges in a timely, cost-effective manner with the ability to efficiently manage data integration projects on an enterprise scale, increasing overall productivity and reducing the total cost of ownership.

  10. Estructuración de un modelo de gestión eficiente para AJ Colombia SAS

    OpenAIRE

    Vargas Gallego, Daniel Felipe; Morales Chavez, Daniela; Ortega Diaz, Melissa

    2016-01-01

    En la mayoría de los países, los negocios familiares representan un alto porcentaje de todas las empresas constituidas. Colombia no es la excepción a este comportamiento, donde las empresas familiares representan el 70% de todas las compañías, según la Superintendencia de Sociedades, en las que se incluyen PYMES y grandes grupos económicos. Este trabajo de grado tiene como objetivo estructurar un modelo de gestión eficiente para la empresa AJ Colombia S.A.S. una empresa mediana que se ha v...

  11. 基于 SAS 机床行业发展的数量化研究%Quantification Study of the Development of the Machine Tool Industry Based on SAS

    Institute of Scientific and Technical Information of China (English)

    翟芳婷

    2014-01-01

    Obtained large historical data of 11 typical industry and six machine tool companies from the stock market by using SAS software ,we get a mathematical formula about the development of machine tool industry by SAS programming , principal component analysis method and multivariate linear regression analysis method .This formula reflects the relationship between the development of machine tool industry and the national economy ,infrastructure ,the real estate .The study pro-vide a reference for the future development and investment of machine tool industry .%利用SAS软件从证券市场上获取11个典型行业和6家机床公司2008~2013年的庞大经济数据,通过SAS编程借助主成份分析法和多元线性回归分析法建立了影响机床行业发展的模型方程,数量化阐述了机床行业发展指数与国民经济、基础设施和房地产三者发展的关系,为机床行业的未来发展及投资提供借鉴。

  12. The High Throughput Sequence Annotation Service (HT-SAS – the shortcut from sequence to true Medline words

    Directory of Open Access Journals (Sweden)

    Siedlecki Pawel

    2009-05-01

    Full Text Available Abstract Background Advances in high-throughput technologies available to modern biology have created an increasing flood of experimentally determined facts. Ordering, managing and describing these raw results is the first step which allows facts to become knowledge. Currently there are limited ways to automatically annotate such data, especially utilizing information deposited in published literature. Results To aid researchers in describing results from high-throughput experiments we developed HT-SAS, a web service for automatic annotation of proteins using general English words. For each protein a poll of Medline abstracts connected to homologous proteins is gathered using the UniProt-Medline link. Overrepresented words are detected using binomial statistics approximation. We tested our automatic approach with a protein test set from SGD to determine the accuracy and usefulness of our approach. We also applied the automatic annotation service to improve annotations of proteins from Plasmodium bergei expressed exclusively during the blood stage. Conclusion Using HT-SAS we created new, or enriched already established annotations for over 20% of proteins from Plasmodium bergei expressed in the blood stage, deposited in PlasmoDB. Our tests show this approach to information extraction provides highly specific keywords, often also when the number of abstracts is limited. Our service should be useful for manual curators, as a complement to manually curated information sources and for researchers working with protein datasets, especially from poorly characterized organisms.

  13. Benchmark of SCALE (SAS2H) isotopic predictions of depletion analyses for San Onofre PWR MOX fuel

    Energy Technology Data Exchange (ETDEWEB)

    Hermann, O.W.

    2000-02-01

    The isotopic composition of mixed-oxide (MOX) fuel, fabricated with both uranium and plutonium, after discharge from reactors is of significant interest to the Fissile Materials Disposition Program. The validation of the SCALE (SAS2H) depletion code for use in the prediction of isotopic compositions of MOX fuel, similar to previous validation studies on uranium-only fueled reactors, has corresponding significance. The EEI-Westinghouse Plutonium Recycle Demonstration Program examined the use of MOX fuel in the San Onofre PWR, Unit 1, during cycles 2 and 3. Isotopic analyses of the MOX spent fuel were conducted on 13 actinides and {sup 148}Nd by either mass or alpha spectrometry. Six fuel pellet samples were taken from four different fuel pins of an irradiated MOX assembly. The measured actinide inventories from those samples has been used to benchmark SAS2H for MOX fuel applications. The average percentage differences in the code results compared with the measurement were {minus}0.9% for {sup 235}U and 5.2% for {sup 239}Pu. The differences for most of the isotopes were significantly larger than in the cases for uranium-only fueled reactors. In general, comparisons of code results with alpha spectrometer data had extreme differences, although the differences in the calculations compared with mass spectrometer analyses were not extremely larger than that of uranium-only fueled reactors. This benchmark study should be useful in estimating uncertainties of inventory, criticality and dose calculations of MOX spent fuel.

  14. EDITORIAL Proceedings of the XIV International Conference on Small-Angle Scattering, SAS-2009

    Science.gov (United States)

    Ungar, Goran; Heenan, Richard

    2010-10-01

    particles based on the radial pair distance distribution function. The model takes account of different types of disorder, i.e. of both 1st ('thermal') and 2nd ('paracrystalline') kind, as well as finite size, stacking and orientational disorder. In paper 012014 Salvino Ciccariello works out the 3D correlation function of plane objects, specifically a triangle of a general shape. This paves the way to analysing morphologies that can be approximated by cylinders of different cross-sections. Papers 012051 (Polte et al.) and 012047 (Bras et al.) report the use of SAS in combination with X-ray spectroscopy. Ristic et al. describe a real-time study of crystal nucleation induced by ultrasound (012049), while Marianne Imperor-Clerc et al. present an investigation of lyotropic liquid crystals under shear (012052). In the Polymers section Geoff Mitchell describes modelling of SANS data on electrospun fibres (012042), while Cabral et al. describes a study of nanoparticle aggregation in bulk and thin polymer films (012046). Work on phospholipid membranes was reported by Spinozzi et al. and by Onai et al. in papers 012019 and 012018, respectively. The latter deals with the effect of osmotic pressure on model 'lipid rafts', these being considered as having an important role in the function of the mammalian cell membrane. Readers interested in biological systems will find a number of other interesting papers describing the use of either SAXS or SANS in the Biological Systems and Membranes section. A number of descriptions of recent designs of SAXS (synchrotron) and SANS beamlines, as well as detector developments can be found in the section on Beamlines and Instrumentation. Goran Ungar, Editor-in-Chief Richard Heenan, Deputy Editor-in-Chief

  15. POSO-MA-SAS 三元共聚物的制备及脱墨应用%Synthesis of terpolymer surfactant POSO-MA-SAS and its deinking performance

    Institute of Scientific and Technical Information of China (English)

    张昌辉; 李强; 李丹; 崔丽萍

    2014-01-01

    The terpolymer anionic surfactant POSO-MA-SAS was synthesized by copolymeri-zation reaction of potassium sorbate (POSO) ,methyl acrylate (MA) and sodium allyl sulfon-ate (SAS) .The better synthesis process and the application to waste paper deinking used washing method was studied ,and terpolymer compounded performance was compared with commercial deinking agent .It was found that the better synthesis condition was determined as follow s :the molar ratio of potassium sorbate (POSO ) to methyl acrylate (M A ) to sodi-um allyl sulfonate (SAS) was 1∶3∶1 at 90 ℃ for 5 h ,dosage of initiator is 6% of monomer mass fraction .The terpolymer has good deinking effect ;the deinking effect was further im-prove when terpolymer compound with AES as the ratio 1∶1 .Compound dosage was 0 .2% , the whiteness of the paper deinked can be increased by 3 .8% ISO compared with commercial-ly available deinking agent and the residual ink concentration was 49 .53 mm2 · m -2 .%以山梨酸钾(POSO)、丙烯酸甲酯(MA)和烯丙基磺酸钠(SAS)为单体通过共聚反应制得POSO-M A-SAS三元共聚物阴离子表面活性剂.研究了最佳合成工艺,考察了共聚物在洗涤法废纸脱墨中的应用,复配后与市售脱墨剂进行了对比.结果表明,当 n(POSO )∶ n (MA)∶ n(SAS)=1∶3∶1,聚合反应温度为90℃,聚合反应时间5 h ,引发剂用量为单体总质量6%时,共聚物具有较好洗涤脱墨效果;共聚物与A ES复配使用时洗涤脱墨效果进一步提高,当m(POSO-MA-SAS)∶ m(AES)=1∶1,用量为0.2%时,脱墨后成纸白度相比市售脱墨剂提高3.8% ISO ,残余油墨量仅为49.53 mm2· m -2.

  16. Comprehensive analysis of interacting proteins and genome-wide location studies of the Sas3-dependent NuA3 histone acetyltransferase complex.

    Science.gov (United States)

    Vicente-Muñoz, Sara; Romero, Paco; Magraner-Pardo, Lorena; Martinez-Jimenez, Celia P; Tordera, Vicente; Pamblanco, Mercè

    2014-01-01

    Histone acetylation affects several aspects of gene regulation, from chromatin remodelling to gene expression, by modulating the interplay between chromatin and key transcriptional regulators. The exact molecular mechanism underlying acetylation patterns and crosstalk with other epigenetic modifications requires further investigation. In budding yeast, these epigenetic markers are produced partly by histone acetyltransferase enzymes, which act as multi-protein complexes. The Sas3-dependent NuA3 complex has received less attention than other histone acetyltransferases (HAT), such as Gcn5-dependent complexes. Here, we report our analysis of Sas3p-interacting proteins using tandem affinity purification (TAP), coupled with mass spectrometry. This analysis revealed Pdp3p, a recently described component of NuA3, to be one of the most abundant Sas3p-interacting proteins. The PDP3 gene, was TAP-tagged and protein complex purification confirmed that Pdp3p co-purified with the NuA3 protein complex, histones, and several transcription-related and chromatin remodelling proteins. Our results also revealed that the protein complexes associated with Sas3p presented HAT activity even in the absence of Gcn5p and vice versa. We also provide evidence that Sas3p cannot substitute Gcn5p in acetylation of lysine 9 in histone H3 in vivo. Genome-wide occupancy of Sas3p using ChIP-on-chip tiled microarrays showed that Sas3p was located preferentially within the 5'-half of the coding regions of target genes, indicating its probable involvement in the transcriptional elongation process. Hence, this work further characterises the function and regulation of the NuA3 complex by identifying novel post-translational modifications in Pdp3p, additional Pdp3p-co-purifying chromatin regulatory proteins involved in chromatin-modifying complex dynamics and gene regulation, and a subset of genes whose transcriptional elongation is controlled by this complex.

  17. Immunomagnetic separation and visual fluorescence detection of E. coli O157 using AOAC approved SAS Molecular Tests.

    Science.gov (United States)

    Bapanpally, Chandra; Maganty, Gayatri; Khan, Shah; Kasra, Akif; Morey, Amit

    2014-01-01

    The SAS Molecular Tests method for the detection of E. coli O157 in various food matrixes has been certified by the AOAC Research Institute and designated Performance Tested Method No. 031203. The current method modification includes the optional immunomagnetic separation (IMS) to enrich the bacteria as well as optional visual fluorescence readout without the use of a turbidimeter. The following study was conducted to validate the proposed modifications against the U.S. Department of Agriculture/Food Safety and Inspection Service Microbiology Laboratory Guidebook (MLG) and the U.S. Food and Drug Administration Bacteriological Analytical Manual (BAM) reference methods. E. coli O157:H7 ATCC 35150 and NM (non-motile) 700377 strains were used to inoculate the ground beef, beef trim, and spinach to obtain 20 low (0.23-2 CFU/test portion) and five high levels (3-5 CFU/test portion) of inoculations. Enriched samples were tested directly and subjected to anti-E. coli IMS prior to the SAS Molecular Tests. Results were determined via visual fluorescence and via turbidity using a turbidimeter. All the replicates, irrespective of the results, were confirmed using MLG 5.05 or BAM Chapter 4A methods. Results indicated that there were no significant differences in the detection of fractional positives (5-15 positives out of 20 replicates) with any of the methods tested above as compared to the reference methods. No false positives or negatives were detected except for two in the ground beef with IMS+Turbidity method. No false-negative samples were detected. Statistical analysis indicated that the modified methods were equivalent to the reference methods in detecting E. coli O157:H7 in the food matrixes tested. SAS Molecular Tests E. coli O157 Detection Kit can be used to detect E. coli O157:H7 in ground beef, beef trim, and spinach. The inclusion of IMS in the modified method improved the detection rate of E. coli O157:H7 in spinach and showed comparable detection rate in ground

  18. Design of a Road Friendly SAS System for Heavy-Duty Vehicles Based on a Fuzzy-Hybrid-ADD and GH-Control Strategy

    Directory of Open Access Journals (Sweden)

    Jing Zhao

    2016-01-01

    Full Text Available Semiactive suspension (SAS system has been widely used for its outstanding performance in offering competent ride quality, road holding, and handling capacity. However, the road friendliness is also one of the crucial factors that should be attached in the design of the SAS system for heavy-duty vehicles. In this study, a fuzzy controlled hybrid-acceleration driven damper (ADD and ground hook- (GH- control strategy is proposed for SAS system of heavy-duty vehicles. Firstly, a quarter-vehicle model with SAS system is constructed. Then, aiming to improve the ride quality and road friendliness, a hybrid-ADD and GH-control strategy is proposed under the coordination of the fuzzy controller. Numerical results show that the ride quality and road friendliness of the SAS system with the proposed control strategy outperform those with traditional hybrid-sky hook and ground hook-control strategy. It is also verified that the proposed strategy is superior to the sole ADD approach and sole ground hook approach in improving the vehicle overall performance.

  19. SPSS and SAS programs for addressing interdependence and basic levels-of-analysis issues in psychological data.

    Science.gov (United States)

    O'Connor, Brian P

    2004-02-01

    Levels-of-analysis issues arise whenever individual-level data are collected from more than one person from the same dyad, family, classroom, work group, or other interaction unit. Interdependence in data from individuals in the same interaction units also violates the independence-of-observations assumption that underlies commonly used statistical tests. This article describes the data analysis challenges that are presented by these issues and presents SPSS and SAS programs for conducting appropriate analyses. The programs conduct the within-and-between-analyses described by Dansereau, Alutto, and Yammarino (1984) and the dyad-level analyses described by Gonzalez and Griffin (1999) and Griffin and Gonzalez (1995). Contrasts with general multilevel modeling procedures are then discussed.

  20. SAS and SPSS macros to calculate standardized Cronbach's alpha using the upper bound of the phi coefficient for dichotomous items.

    Science.gov (United States)

    Sun, Wei; Chou, Chih-Ping; Stacy, Alan W; Ma, Huiyan; Unger, Jennifer; Gallaher, Peggy

    2007-02-01

    Cronbach's a is widely used in social science research to estimate the internal consistency of reliability of a measurement scale. However, when items are not strictly parallel, the Cronbach's a coefficient provides a lower-bound estimate of true reliability, and this estimate may be further biased downward when items are dichotomous. The estimation of standardized Cronbach's a for a scale with dichotomous items can be improved by using the upper bound of coefficient phi. SAS and SPSS macros have been developed in this article to obtain standardized Cronbach's a via this method. The simulation analysis showed that Cronbach's a from upper-bound phi might be appropriate for estimating the real reliability when standardized Cronbach's a is problematic.

  1. Mediation analysis allowing for exposure-mediator interactions and causal interpretation: theoretical assumptions and implementation with SAS and SPSS macros.

    Science.gov (United States)

    Valeri, Linda; Vanderweele, Tyler J

    2013-06-01

    Mediation analysis is a useful and widely employed approach to studies in the field of psychology and in the social and biomedical sciences. The contributions of this article are several-fold. First we seek to bring the developments in mediation analysis for nonlinear models within the counterfactual framework to the psychology audience in an accessible format and compare the sorts of inferences about mediation that are possible in the presence of exposure-mediator interaction when using a counterfactual versus the standard statistical approach. Second, the work by VanderWeele and Vansteelandt (2009, 2010) is extended here to allow for dichotomous mediators and count outcomes. Third, we provide SAS and SPSS macros to implement all of these mediation analysis techniques automatically, and we compare the types of inferences about mediation that are allowed by a variety of software macros.

  2. VecDec4SAS program for analyzing the dynamic processes observed by the small-angle scattering technique

    Science.gov (United States)

    Molodenskii, D. S.

    2017-01-01

    A VecDec4SAS program has been developed to provide a fast and easy description of the dynamics of any process occurring in a nanoparticle solution observed by the small-angle scattering technique. The process should be characterized by the some conditional initial and final stages, in fractions of which all intermediate data are expanded. The program makes it possible to estimate the adequacy of two-basis approximation and indicate the presence of an additional process introducing a systematic error into the initial data. Scattering curves for human serum albumin protein in solutions with pH 7.4 and 3.0 and a concentration of 20 mg/mL, obtained on the DICSY station at the National Research Centre "Kurchatov Institute" in the solution temperature range from 25 to 70°C, were taken to be initial data to illustrate the potential of the program.

  3. Modification of the SAS4A Safety Analysis Code for Integration with the ADAPT Discrete Dynamic Event Tree Framework.

    Energy Technology Data Exchange (ETDEWEB)

    Jankovsky, Zachary Kyle [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Denman, Matthew R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-05-01

    It is difficult to assess the consequences of a transient in a sodium-cooled fast reactor (SFR) using traditional probabilistic risk assessment (PRA) methods, as numerous safety-related sys- tems have passive characteristics. Often there is significant dependence on the value of con- tinuous stochastic parameters rather than binary success/failure determinations. One form of dynamic PRA uses a system simulator to represent the progression of a transient, tracking events through time in a discrete dynamic event tree (DDET). In order to function in a DDET environment, a simulator must have characteristics that make it amenable to changing physical parameters midway through the analysis. The SAS4A SFR system analysis code did not have these characteristics as received. This report describes the code modifications made to allow dynamic operation as well as the linking to a Sandia DDET driver code. A test case is briefly described to demonstrate the utility of the changes.

  4. Homology modeling and validation of SAS2271 transcriptional regulator of AraC family in Staphylococcus aureus

    Directory of Open Access Journals (Sweden)

    Money Gupta

    2013-02-01

    Full Text Available Objective: To predict three dimensional structure of AraC Family transcription regulator protein in staphylococcus aureus involved in causing virulence. Methods: Evolutionary dynamics of S. aureus reveled that several mutations preceding virulence lead to truncated proteins that plays an important role in virulence. The Structural templates are identified using homology search and then homology modelling is used to get the 3-D structure of the protein. Results: The 3-D structure of SAS2271 transcriptional factor of AraC family in MSSA476 strain of S. aureus was modelled and validated using the Ramachandran plot. Conclusions: The knowledge of 3-D structure of the protein will be helpful in identifying its biochemical function along with its regulatory mechanism in causing virulence.

  5. Data Ellipses, HE Plots and Reduced-Rank Displays for Multivariate Linear Models: SAS Software and Examples

    Directory of Open Access Journals (Sweden)

    Michael Friendly

    2006-11-01

    Full Text Available This paper describes graphical methods for multiple-response data within the framework of the multivariate linear model (MLM, aimed at understanding what is being tested in a multivariate test, and how factor/predictor effects are expressed across multiple response measures. In particular, we describe and illustrate a collection of SAS macro programs for: (a Data ellipses and low-rank biplots for multivariate data, (b HE plots, showing the hypothesis and error covariance matrices for a given pair of responses, and a given effect, (c HE plot matrices, showing all pairwise HE plots, and (d low-rank analogs of HE plots, showing all observations, group means, and their relations to the response variables.

  6. Battlefield Utility of Antipersonnel Landmines and Proposed Alternatives (Analysis in Support of the NATO SAS-023 APM Study)

    Energy Technology Data Exchange (ETDEWEB)

    Crandley, J F; Greenwalt, R J; Magnoli, D E; Randazzo, A S

    2002-02-05

    This study consists of work done in support of the U.S. delegation to the NATO SAS-023 Antipersonnel Landmine Study Group, supplemented by additional work done for the U.S. Office of the Secretary of Defense Antipersonnel Landmine Alternative Concept Exploration Program (Track III). It explores the battlefield utility of current antipersonnel landmines (APL) in both pure and mixed APL/antitank minefields and evaluates the value of military suggested non-materiel alternatives. The historical record is full of examples where the presence (or absence) of antipersonnel landmines made a critical difference in battle. The current generation of military thinkers and writers lack any significant combat experience employing either mixed or antipersonnel minefields, which leaves a critical gap in available expert advice for policy and decision-makers. Because of this lack of experienced-based professional military knowledge, Lawrence Livermore National Laboratory analyzed the employment of antipersonnel landmines in tactical mixed minefields and in protective antipersonnel minefields. The scientific method was employed where hypotheses were generated from the tactics and doctrine of the antipersonnel landmine era and tested in a simulation laboratory. A high-resolution, U.S. Joint Forces Command combat simulation model (the Joint Conflict and Tactical Simulation--JCATS) was used as the laboratory instrument. A realistic European scenario was obtained from a multi-national USAREUR exercise and was approved by the SAS-023 panel members. Additional scenarios were provided by U.S. CINC conferences and were based on Southwest Asia and Northeast Asia. Weapons data was obtained from the U.S. family of Joint Munitions Effectiveness Manuals. The U.S. Army Materiel Systems Analysis Agency conducted a limited verification and validation assessment of JCATS for purposes of this study.

  7. The Spectral Analysis of X-Ray Binaries from the XMM-Newton Space Craft Data using SAS Software

    Science.gov (United States)

    Baki, P.; Mito, C. O.

    2009-10-01

    A spectral data analysis on a luminous object of sky-coordinates 12h52m24.28s-29d115'02.3'12.6arcsec using Science Analysis Software (SAS) is presented. The analysis, based on data acquired by the Reflection Grating Spectrometer (RGS) camera aboard the XMM-Newton Space satellite, shows that the primary constituents of the X-ray source are Fe (Iron) and O (oxygen). This suggests that the source may be a magnetized plasma in a binary system and as this magnetic field accelerates the cooling of a star, one may speculate that this may be a compact star in its last stages of a thermonuclear fusion process. Nous présentons une analyse du spectre d'une source a rayons X située -- en coordonnées sidérales - à 12h52m24.28s - 29d115'02.312.6 arcsec. Science Analysis Software (SAS) est le programme informatique utilisé pour l'analyse des données. Cette analyse est basée sur les données provenant du spectromètre à haute résolution (RGS) à bord du satellite spatiale XMM-Newton. Nous montrons que ladite source est principalement constituée de Fer (Fe) et d'oxygene (O). Ce résultat suggère que la source pourrait être un plasma magnétisé au sein d'un système binaire. Et du fait que ce champ magnétique accélère le refroidissement de l'étoile, nous supposons que cette étoile pourrait ètre un objet compact en phase terminale d'un processus de fusion thermonucléaire.

  8. 新的细胞壁锚定蛋白SasX对金黄葡萄球菌生物膜形成和毒力的影响%The novel surface-anchored protein SasX promotes biofilm formation and is a virulence factor of Staphylococcus aureus

    Institute of Scientific and Technical Information of China (English)

    杜昕; 宋燕; 胡锦辉; 阮斐怡; 吕元; 李敏

    2011-01-01

    Objective To determine whether the novel surface-anchored protein SasX mediates biofilm formation of Staphylococcus aureus and to investigate the function of SasX in the virulence of S.aureus.Methods Methicillin-resistant Staphylococcus aureus(MRSA) ST-239 HS sasX gene mutant (HS770 △ sasX) and complement [ HS770 △sasX(pRBsasX) ] were gotten by gene knock out and complement methods.Semiquantitative biofilm assay was used for detection of the biofilm formation of wild type and mutant.By using abscess model in mice,we investigate the function of SasX in the virulence of S.aureus.Results The sasX gene mutant strain was gotten successfully by using pKOR1 plasmid.HS770 △sasX with a very clear reduction of biofilm formation compared to wild type and complement(P<0.05),there was no significant difference of biofilm formation between wild type and complement(P>0.05).Primary attachment assays demonstrated that comparing to wild type,there was significant reduction of initial accumulative phases of biofilm development in HS770△sasX(P<0.05),but there was no difference between wild type and complement(P>0.05).Both sasX wild type and mutant could cause abscess in the skin of mice,no abscess were forming in the PBS control group.The biggest abscess size was found on the second day after injection.The size of abscess was smaller with extension of the time.But on the same time,the wild type group produced significantly larger abscesses compared to mutant group( P<0.05 ).Conclusion It could improve the effect of gene knocking out by using pKOR1 plasmid.SasX promotes biofilm formation by influencing on the initial accumulative phases of biofilm development,SasX is a marker of invasive infection of S.aureus,it is very important for S.aureus persistence in the hospital setting.%目的 研究新的细胞壁锚定蛋白SasX对金黄葡萄球菌生物膜形成及毒力的影响.方法 采用基因敲除及基因互补技术获得耐甲

  9. Distribution of the novel cell wall anchored protein-encoding gene sasX in Staphylococcus aureus strains%新的细胞壁锚定蛋白编码基因sasX在金黄色葡萄球菌中的分布

    Institute of Scientific and Technical Information of China (English)

    杜昕; 宋燕; 田月如; 阮斐怡; 吕元; 李敏

    2011-01-01

    Objective To investigate the distribution and effect on antibiotic resistance of the novel cell wall anchored protein-encoding gene sasX.Methods A total of 300 S.aureus isolates were randomly collected from inpatients with S.aureus infection in Shanghai Huashan hospital in 2004, 2007 and 2010.Meanwhile,170 S.aureus isolates from the nasal swabs of healthy people were collected as part of a population-based community prevalence study.Typing of S.aureus isolates were identified by using multilocus sequence typing (MLST) and S.aureus-specific staphylococcal protein A typing (spa typing).Determination of oxacillin MICs was used to screen MRSA.PCR and sequencing were used to analyze sasX gene.The effect on antibiotic resistance of sasX gene was detect by disc agar diffusion drug sensitive test.Results The major clonal types of the 300 S.aureus isolates collected from inpatients with S.aureus infection were ST239 ( 110,36.7%) and ST5 (122,40.7%).From 2004 to 2010,the percentage of isolates from inpatients with S.aureus infection was increased from 17% to 39%,but sasX was only found in 0.59% of the S.aureus isolates from the nasal swabs of healthy people.The percentage of sasX positive was increased from 47.2% to 83.8% in ST239.The percentage of sasX positive MRSA was increased from 26.4% to 50.8%,but the percentage of sasX positive MSSA was about 10%.Antibiotic resistance of sasX positive strains were higher than that of sasX negative strains.Conclusions SasX gene is mainly detected in nosocomial pathogenic S.aureus and it is a possible virulence factor of S.aureus in hosptal setting.The presence of sasX gene is related to antibiotic resistance.For better understanding the real function of this novel gene,further studies such as expression of the encoded protein should be carried out.%目的 研究细胞壁锚定蛋白编码基因sasX在金黄色葡萄球菌中的分布及对细菌耐药性的影响.方法 随机收集上海华山医院2004、2007

  10. Combined SAXS/EM Based Models of the S. elongatus Post-Translational Circadian Oscillator and its Interactions with the Output His-Kinase SasA

    Energy Technology Data Exchange (ETDEWEB)

    Pattanayek, Rekha; Williams, Dewight R.; Rossi, Gian; Weigand, Steven; Mori, Tetsuya; Johnson, Carl H.; Stewart, Phoebe L.; Egli, Martin (Vanderbilt); (NWU)

    2012-03-15

    The circadian clock in the cyanobacterium Synechococcus elongatus is composed of a post-translational oscillator (PTO) that can be reconstituted in vitro from three different proteins in the presence of ATP and a transcription-translation feedback loop (TTFL). The homo-hexameric KaiC kinase, phosphatase and ATPase alternates between hypo- and hyper-phosphorylated states over the 24-h cycle, with KaiA enhancing phosphorylation, and KaiB antagonizing KaiA and promoting KaiC subunit exchange. SasA is a His kinase that relays output signals from the PTO formed by the three Kai proteins to the TTFL. Although the crystal structures for all three Kai proteins are known, atomic resolution structures of Kai and Kai/SasA protein complexes have remained elusive. Here, we present models of the KaiAC and KaiBC complexes derived from solution small angle X-ray scattering (SAXS), which are consistent with previous EM based models. We also present a combined SAXS/EM model of the KaiC/SasA complex, which has two N-terminal SasA sensory domains occupying positions on the C-terminal KaiC ring reminiscent of the orientations adopted by KaiB dimers. Using EM we demonstrate that KaiB and SasA compete for similar binding sites on KaiC. We also propose an EM based model of the ternary KaiABC complex that is consistent with the sequestering of KaiA by KaiB on KaiC during the PTO dephosphorylation phase. This work provides the first 3D-catalogue of protein-protein interactions in the KaiABC PTO and the output pathway mediated by SasA.

  11. Developing a 300C Analog Tool for EGS

    Energy Technology Data Exchange (ETDEWEB)

    Normann, Randy

    2015-03-23

    This paper covers the development of a 300°C geothermal well monitoring tool for supporting future EGS (enhanced geothermal systems) power production. This is the first of 3 tools planed. This is an analog tool designed for monitoring well pressure and temperature. There is discussion on 3 different circuit topologies and the development of the supporting surface electronics and software. There is information on testing electronic circuits and component. One of the major components is the cable used to connect the analog tool to the surface.

  12. 索尼爱立信W300c

    Institute of Scientific and Technical Information of China (English)

    王嘉

    2006-01-01

    作为索尼爱立信Walkman手机家族的新成员,W300c是第一款采用翻盖设计的Walkman机型,同时也是今年攻占中端娱乐手机市场的主力机型。因此,W300c在白、黑两种出厂颜色的基础上还采用了受年轻人欢迎的Style-up可换彩壳设计,

  13. 21 CFR 520.300c - Cambendazole paste.

    Science.gov (United States)

    2010-04-01

    ...) of this chapter. (c) Conditions of use. (1) It is used in horses for the control of large strongyles... kilograms)) by depositing the paste on the back of the tongue using a dosing gun. (3) For animals maintained... in the diagnosis, treatment, and control of parasitism....

  14. Diseño de una Oficina de Gestión de Proyectos (PMO) para la empresa RINCCO S.A.S.

    OpenAIRE

    Arias Sánchez, Néstor Jaime

    2015-01-01

    La Reforestadora industrial y comercial de Colombia S.A.S. (RINCCO S.A.S.) empresa del sector forestal, mueble y madera ha definido como visión organizacional ser una empresa líder en producción, transformación y comercialización de productos maderables -- Es un momento clave para empresa, ya que de las decisiones que se tomen hoy, dependerá si esta visión se vuelve una realidad -- Como base para poder emprender este camino deberá establecer en su estructura organizacional procesos que le per...

  15. PERBANDINGAN PEMBELAJARANMEMBACA PERMULAAN DENGAN MENGGUNAKAN METODE SAS DANMETODE KATA LEMBAGA BERDASARKAN PERBEDAAN GAYA BELAJAR PADA PESERTA DIDIK TAMAN KANAK-KANAK

    Directory of Open Access Journals (Sweden)

    Wiwik Kus Endah

    2014-08-01

    Full Text Available Penelitian ini bertujuan untuk membuktikan (1 perbedaan kemampuan membaca permulaan antara peserta didik taman kanak-kanak bergaya belajar auditori dan visual yang dibimbing dengan metode SAS, (2 perbedaan kemampuan membaca permulaan antara peserta didik taman kanak-kanak bergaya belajar auditori dan visual yang dibimbing dengan metode  kata lembaga, (3 interaksi antara penggunaan metode SAS dan metode kata lembaga untuk meningkatkan kemampuan membaca permulaan peserta didik taman kanak-kanak bergaya belajar auditori dan visual. Metode penelitian ini exsperimental design. Teknik pengumpulan data penelitian menggunakan instrumen tes kemampuan membaca permulaan, modality assessment test, wawancara, lembar observasi, dan dokumentasi. Untuk menganalisis data penelitian digunakan one sample kolmogorov-smirnov test pada program SPSS 16, uji homogenitas levene test, dan uji hipotesis dengan analisis varian 2x2. Simpulan hasil penelitian ini yaitu (1 terdapat perbedaan kemampuan membaca permulaan antara peserta didik TK Islam Pangeran Diponegoro yang memiliki gaya belajar auditori dan visual yang dibimbing dengan metode SAS, (2 terdapat perbedaan kemampuan membaca permulaan antara peserta didik TK Islam Pangeran Diponegoro yang memiliki gaya belajar auditori dan visual yang dibimbing dengan metode kata lembaga dan (3 terdapat interaksi antara penggunaan metode pembelajaran (SAS dan kata lembaga dengan gaya belajar (auditori dan visual  pada kemampuan membaca permulaan peserta didik taman kanak-kanak.This study aimed to describe (1 the difference between the beginning reading skills of students kindergarten auditory and visual learning style that is guided by the SAS method; (2 the difference between the beginning reading skills of students kindergarten style learning auditory and visual guided the “kata lembaga”method;and (3 the interaction between the use of SAS methods and methods of ‘kata lembaga”to improve literacy learners beginning

  16. CVD silicon carbide monofilament reinforced SrO-Al2O3-2SiO2 (SAS) glass-ceramic composites

    Science.gov (United States)

    Bansal, Narottam P.

    1995-01-01

    Unidirectional CVD SiC fiber-reinforced SrO.Al2O3.2SiO2 (SAS) glass-ceramic matrix composites have been fabricated by hot pressing at various combinations of temperature, pressure and time. Both carbon-rich surface coated SCS-6 and uncoated SCS-0 fibers were used as reinforcements. Almost fully dense composites have been obtained. Monoclinic celsian, SrAl2Si2O8, was the only crystalline phase observed in the matrix from x-ray diffraction. During three point flexure testing of composites, a test span to thickness ratio of approximately 25 or greater was necessary to avoid sample delamination. Strong and tough SCS-6/SAS composites having a first matrix crack stress of approximately 300 MPa and an ultimate bend strength of approximately 825 MPa were fabricated. No chemical reaction between the SCS-6 fibers and the SAS matrix was observed after high temperature processing. The uncoated SCS-0 fiber-reinforced SAS composites showed only limited improvement in strength over SAS monolithic. The SCS-0/SAS composite having a fiber volume fraction of 0.24 and hot pressed at 1400 deg C exhibited a first matrix cracking stress of approximately 231 +/- 20 MPa and ultimate strength of 265 +/- 17 MPa. From fiber push-out tests, the fiber/matrix interfacial debonding strength (tau(sub debond)) and frictional sliding stress (tau(sub friction)) in the SCS-6/SAS system were evaluated to be approximately 6.7 +/- 2.3 MPa and 4.3 +/- 0.6 MPa, respectively, indicating a weak interface. However, for the SCS-0/SAS composite, much higher values of approximately 17.5 +/- 2.7 MPa for tau(sub debond) and 11.3 +/- 1.6 MPa for tau(sub friction) respectively, were observed; some of the fibers were so strongly bonded to the matrix that they could not be pushed out. Examination of fracture surfaces revealed limited short pull-out length of SCS-0 fibers. The applicability of various micromechanical models for predicting the values of first matrix cracking stress and ultimate strength of these

  17. Stratospheric Air Sub-sampler (SAS) and its application to analysis of Δ17O(CO2) from small air samples collected with an AirCore

    Science.gov (United States)

    Janina Mrozek, Dorota; van der Veen, Carina; Hofmann, Magdalena E. G.; Chen, Huilin; Kivi, Rigel; Heikkinen, Pauli; Röckmann, Thomas

    2016-11-01

    We present the set-up and a scientific application of the Stratospheric Air Sub-sampler (SAS), a device to collect and to store the vertical profile of air collected with an AirCore (Karion et al., 2010) in numerous sub-samples for later analysis in the laboratory. The SAS described here is a 20 m long 1/4 inch stainless steel tubing that is separated by eleven valves to divide the tubing into 10 identical segments, but it can be easily adapted to collect smaller or larger samples. In the collection phase the SAS is directly connected to the outlet of an optical analyzer that measures the mole fractions of CO2, CH4 and CO from an AirCore sampler. The stratospheric part (or if desired any part of the AirCore air) is then directed through the SAS. When the SAS is filled with the selected air, the valves are closed and the vertical profile is maintained in the different segments of the SAS. The segments can later be analysed to retrieve vertical profiles of other trace gas signatures that require slower instrumentation. As an application, we describe the coupling of the SAS to an analytical system to determine the 17O excess of CO2, which is a tracer for photochemical processing of stratospheric air. For this purpose the analytical system described by Mrozek et al. (2015) was adapted for analysis of air directly from the SAS. The performance of the coupled system is demonstrated for a set of air samples from an AirCore flight in November 2014 near Sodankylä, Finland. The standard error for a 25 mL air sample at stratospheric CO2 mole fraction is 0.56 ‰ (1σ) for δ17O and 0.03 ‰ (1σ) for both δ18O and δ13C. Measured Δ17O(CO2) values show a clear correlation with N2O in agreement with already published data.

  18. Preparation of HA/P(AM-SAS) blend and their inhibition performance of scale and corrosion%改性腐植酸新型阻垢缓蚀剂的制备及应用

    Institute of Scientific and Technical Information of China (English)

    邱广明; 邱广亮

    2001-01-01

    The blends [HA/P(AM-SAS)]of humic acids(HA)and copolymer P(AM-SAS) of acrylamide(AM) and sodium allylsulfonate(SAS) have been prepared by solution blend. Their inhibition performance of scale and corrosion and dispersion performance have been studied and compared with HA and P(AM-SAS). Experimental results indicates that their scale and corrosion inhibition rates and dispersing Fe2O3 capability increase with the increasing of their concentration. Compared with HA and P(AM-SAS),HA/P(AM-SAS)blends have better scale and corrosion inhibition performance and dispersion capability. During the blending of HA and P(AM-SAS),HA and P(AM-SAS)have synergistic effects for CaCO3 and Ca3(PO4)2 scale inhibition when HA/P(AM-SAS)mass ratio is above 1 and 2.Under the condition:ρ(Ca2+)=250 mg/L、ρ(HCO3-)=250 mg/L、ρ(CO32-)=85 mg/L、ρ(PO43-)=5 mg/L、pH=8.5、T=80 ℃、t=10 h,the inhibition rates of HA/P(AM-SAS)blends on the CaCO3 and Ca3(PO4)2 scale are up to 98.9%and 97.2%respectively. When the dosage ofHA/P(AM-SAS)blends is beyond 20 mg/L,the corrosion inhibition rate on mild steel reaches 95.0%.%采用溶液共混技术,制备了腐植酸钠(HA)和丙烯酰胺—烯丙基磺酸钠(SAS)共聚物[P(AM-SAS)]的共混物[HA/P(AM-SAS)],研究了共混物[HA/P(AM-SAS)]的阻垢、缓蚀和分散性能,并与HA和P(AM-SAS)做了对比分析。实验表明,HA/P(AM-SAS)共混物、HA和P(AM-SAS)的阻垢、缓蚀和分散能力随着使用浓度的增加而提高。与HA和P(AM-SAS)相比,HA/P(AM-SAS)共混物具有更好的阻垢、缓蚀和分散能力。当HA/P(AM-SAS)质量比超过1或2时,HA和P(AM-SAS)的共混对于CaCO3和Ca3(PO4)2的阻垢作用表现出了明显的协同效应。当ρ(Ca2+)=250 mg/L、ρ(HCO3-)=250 mg/L、ρ(CO32-)=85 mg/L、ρ(PO43-)=5 mg/L、pH=8.5、T=80 ℃、t=10 h时,HA/P(AM-SAS)共混物对CaCO3和Ca3(PO4)2的阻垢率分别达到了98.9%和97.2%。当HA/P(AM-SAS)共混物的使用浓度超过20 mg/L,共混物

  19. Development of PCR protocols for specific identification of Clostridium spiroforme and detection of sas and sbs genes.

    Science.gov (United States)

    Drigo, Ilenia; Bacchin, Cosetta; Cocchi, Monia; Bano, Luca; Agnoletti, Fabrizio

    2008-10-15

    Rabbit diarrhoea caused by toxigenic Clostridium spiroforme is responsible for significant losses in commercial rabbitries but the accurate identification of this micro-organism is difficult due to the absence of both a commercial biochemical panel and biomolecular methods. The aim of this study was therefore to develop PCR protocols for specific detection of C. spiroforme and its binary toxin encoding genes. The C. spiroforme specie-specific primers were designed based on its 16S rDNA published sequences and the specificity of these primers was tested with DNA extracted from closely related Clostridium species. The sa/bs_F and sa/bs _R C. spiroforme binary toxin specific primers were designed to be complementary, respectively, to a sequence of 21 bases on the 3' and of sas gene and on the 5' of the sbs gene. The detection limits of in house developed PCR protocols were 25CFU/ml of bacterial suspension and 1.38x10(4)CFU/g of caecal content for specie-specific primers and 80CFU/ml of bacterial suspension and 2.8x10(4)CFU/g of caecal content in case of sa/bs primers. These results indicated that the described PCR assays enable specific identification of C. spiroforme and its binary toxin genes and can therefore be considered a rapid, reliable tool for the diagnosis of C. spiroforme-related enterotoxaemia.

  20. NParCov3: A SAS/IML Macro for Nonparametric Randomization-Based Analysis of Covariance

    Directory of Open Access Journals (Sweden)

    Richard C. Zink

    2012-07-01

    Full Text Available Analysis of covariance serves two important purposes in a randomized clinical trial. First, there is a reduction of variance for the treatment effect which provides more powerful statistical tests and more precise confidence intervals. Second, it provides estimates of the treatment effect which are adjusted for random imbalances of covariates between the treatment groups. The nonparametric analysis of covariance method of Koch, Tangen, Jung, and Amara (1998 defines a very general methodology using weighted least-squares to generate covariate-adjusted treatment effects with minimal assumptions. This methodology is general in its applicability to a variety of outcomes, whether continuous, binary, ordinal, incidence density or time-to-event. Further, its use has been illustrated in many clinical trial settings, such as multi-center, dose-response and non-inferiority trials.NParCov3 is a SAS/IML macro written to conduct the nonparametric randomization-based covariance analyses of Koch et al. (1998. The software can analyze a variety of outcomes and can account for stratification. Data from multiple clinical trials will be used for illustration.

  1. SNP_NLMM: A SAS Macro to Implement a Flexible Random Effects Density for Generalized Linear and Nonlinear Mixed Models.

    Science.gov (United States)

    Vock, David M; Davidian, Marie; Tsiatis, Anastasios A

    2014-01-01

    Generalized linear and nonlinear mixed models (GMMMs and NLMMs) are commonly used to represent non-Gaussian or nonlinear longitudinal or clustered data. A common assumption is that the random effects are Gaussian. However, this assumption may be unrealistic in some applications, and misspecification of the random effects density may lead to maximum likelihood parameter estimators that are inconsistent, biased, and inefficient. Because testing if the random effects are Gaussian is difficult, previous research has recommended using a flexible random effects density. However, computational limitations have precluded widespread use of flexible random effects densities for GLMMs and NLMMs. We develop a SAS macro, SNP_NLMM, that overcomes the computational challenges to fit GLMMs and NLMMs where the random effects are assumed to follow a smooth density that can be represented by the seminonparametric formulation proposed by Gallant and Nychka (1987). The macro is flexible enough to allow for any density of the response conditional on the random effects and any nonlinear mean trajectory. We demonstrate the SNP_NLMM macro on a GLMM of the disease progression of toenail infection and on a NLMM of intravenous drug concentration over time.

  2. Supplier Assessment System (SAS)

    Science.gov (United States)

    Dietrich, Kristen

    2016-01-01

    Background: Sponsored by NASA Headquarters; Charter - provide information to assist the quality assurance community in evaluating and determining supplier risk; Comprehensive on-line repository of supplier information; Available to approved civil service personnel from all NASA Centers, other U.S. Government Agencies, Prime Contractors, and NASA direct support contractors; User access to specific data types or documents is controlled as needed.

  3. Sustainable Ammunition Safety (SAS)

    NARCIS (Netherlands)

    Klerk, W.P.C. de; Hooijmeijer, P.; Harmelen, P. van

    2014-01-01

    In the Netherlands, no national industry in the field of energetic materials / ammunition for military applications is available. The knowledge of explosives, ammunition and ammunition on the vulnerability of platforms is limited, first to Defence regarding the logistical and operational practice an

  4. From Uhuru at CfA to SAS-3 at MIT: Looking for X-Ray Binaries in all the Right Places

    Science.gov (United States)

    Cominsky, Lynn R.

    2013-01-01

    My career in X-ray astronomy started almost accidentally, when in 1975 I was hired fresh out of college as a “data aide” for the Uhuru satellite, in Riccardo Giacconi’s group at the Harvard-Smithsonian Center for Astrophysics. Working first for Mel Ulmer, and later for Bill Forman and Christine Jones, I learned the fundamentals of data analysis, and helped produce the Fourth Uhuru catalog of X-ray sources (Forman et al. 1978), as well as studying transient X-ray sources (Cominsky et al. 1978). Christine was the first woman scientist I had ever met, and with her encouragement, I applied to graduate school to continue on in X-ray astronomy. Lured down the street to MIT by the chance to work on SAS-3, I eagerly learned how to operate the satellite from a control room in the Center for Space Research. The SAS-3 group was led by Prof. George Clark, and it was my good luck that he was around during the holiday break in January 1978 when everyone else in the group was at an AAS meeting in Hawaii. A source I recognized from my Uhuru work, 4U0115+63, had reappeared, and I knew that it was likely to be a pulsar. With the help of George and Project Scientist Bill Mayer, I managed to send the commands to stop SAS-3 and point at the source. The 3.6 second pulsations were so strong that they could be seen in the raw data! This discovery made the New York Times, as 4U0115+63 was the first transient x-ray source shown to be in a binary system (Cominsky et al. 1978, Rappaport et al. 1978). Another personal SAS-3 highlight included working on Prof. Walter Lewin’s “World-wide Burst Watch” - coordinated multi-wavelength observations of x-ray burst sources which led to the discoveries of slightly delayed but coincident optical bursts (Grindlay et al. 1978, McClintock et al. 1979). Although live operations of SAS-3 ended when it re-entered on April 9, 1979, many years of additional data analysis remained. And later, as a continuation of work I began in my Ph.D. Thesis on X

  5. SAS implementation of the multi index panel data clustering%多指标面板数据聚类的 SAS实现

    Institute of Scientific and Technical Information of China (English)

    姜超

    2013-01-01

    基于多指标面板数据聚类的理论,以全国31个省市的城市化水平为例,介绍利用SAS编程实现此聚类方法的过程,结果表明,该SAS程序显示了良好的应用性,为多指标面板数据聚类的实现提供了参考和依据。%Multi index panel data clustering based on the theory of the city,the 31 provinces and municipalities level as an example,intro-duces the process,the clustering method by using SAS program shows that,the SAS program shows good application,provides the reference and the basis for the realization of multi index panel data clustering.

  6. Meta-Analysis of Ordinal Data and Its Solution by SAS%有序数据的Meta分析方法及SAS实现

    Institute of Scientific and Technical Information of China (English)

    张天嵩; 熊茜

    2012-01-01

    目的 介绍有序数据的Meta分析方法及其在SAS软件的实现.方法 以实例说明,采用两步法:第一步,基于累积比数模型,采用SAS中的GENMOD过程计算产生每个研究的效应量及其标准误;第二步,采用固定效应模型和随机效应模型以SAS中的MIXED过程进行经典Meta分析.结果 固定效应和随机效应模型Meta分析结果显示,汇总比值比及95%可信区间均为2.853 9(2.106 4,3.864 8).结论 对于有序数据,可以应用SAS中的GENMOD过程和MIXED过程进行Meta分析.%Objective To introduce methodology for undertaking a meta-analysis on ordinal data and its realization in SAS. Methods It was illustrated on an example data by using two-step method. In the first step, it was calculated treatment effect and its standard error for an individual study by using PROC GENMOD in SAS based on cumulative odds models; in the second step, a classical meta-analysis was proposed for fixed and random effect model by using PROC MIXED in SAS. Results Results from the traditional meta-analysis of summary odds ratio and its 95% CI were same 2.853 9(2.106 4,3.864 8) for fixed and random effect model. Conclusions The procedure SAS PROC GENMOD and MIXED were utilized to undertake a meta-analysis on ordinal data.

  7. The Application of the SAS Software in Chemical Education%SAS统计软件在化学教育上的应用

    Institute of Scientific and Technical Information of China (English)

    王琴

    2007-01-01

    报道了SAS(统计分析系统)软件的特点.列举了一些在化学教育研究中使用SAS软件应用的实例.这一软件可实现化学、数学和计算机技术的良好结合,SAS软件已在化学教育和科研中获得了广泛应用.

  8. Small-angle scattering computed tomography (SAS-CT) using a Talbot-Lau interferometerand a rotating anode x-ray tube:theory and experiments.

    Science.gov (United States)

    Chen, Guang-Hong; Bevins, Nicholas; Zambelli, Joseph; Qi, Zhihua

    2010-06-01

    X-ray differential phase contrast imaging methods, including projection imaging and the corresponding computed tomography (CT), have been implemented using a Talbot interferometer and either a synchrotron beam line or a low brilliance x-ray source generated by a stationary-anode x-ray tube. From small-angle scattering events which occur as an x-ray propagates through a medium, a signal intensity loss can be recorded and analyzed for an understanding of the micro-structures in an image object. This has been demonstrated using a Talbot-Lau interferometer and a stationary-anode x-ray tube. In this paper, theoretical principles and an experimental implementation of the corresponding CT imaging method are presented. First, a line integral is derived from analyzing the cross section of the small-angle scattering events. This method is referred to as small-angle scattering computed tomography (SAS-CT). Next, a Talbot-Lau interferometer and a rotating-anode x-ray tube were used to implement SAS-CT. A physical phantom and human breast tissue sample were used to demonstrate the reconstructed SAS-CT image volumes.

  9. Studies on prevalence of biofilm associated genes and primary observation on sasX gene in clinical isolates of coagulase negative staphylococci (CoNS).

    Science.gov (United States)

    Soumya, Kandammuriyil Radhakrishnan; Mathew, Shiji; Sugathan, Sheela; Mathew, Jyothis; Radhakrishnan, Edayileveettil Krishnankutty

    2016-04-01

    Coagulase negative staphylococci (CoNS) are nosocomial pathogens that cause indwelling medical device associated infections due to its biofilm forming potential and multiple antibiotic resistance. The current study focused on species identification, antibiotic resistance profile and molecular basis of biofilm formation and attachment of CoNS isolated from clinical samples. Along with this, molecular screening for mecA and newly identified surface colonization protein encoded by sasX gene was also conducted. S. epidermidis (n = 19, 47%) was identified as the most prevalent CoNS species and very interestingly two biofilm forming, mecA positive S. epidermidis isolates were found to carry all the biofilm associated genes screened in this study, which indicates its potential to form the strong biofilm. Another novel observation of the study is the detection of sasX gene in one biofilm positive S. epidermidis isolate. The study also identified one doxycycline resistant mecA positive, multidrug resistant S. haemolyticus isolate. In conclusion, the study signifies the existence of multiple biofilm related genes, multidrug resistance and the presence of sasX gene among clinical isolates of CoNS.

  10. On Teaching Problems about Medical Statistics SAS Experimental Courses%医学统计学SAS实验课程相关教学问题探讨

    Institute of Scientific and Technical Information of China (English)

    汤在祥

    2012-01-01

    SAS软件实验课是医学统计学的重要课程,上好SAS软件实验课对于学生掌握和应用统计学方法具有重要实践意义。针对医学统计学SAS软件实验课特点,以及当前教学过程中存在的问题,对SAS软件实验课了提出了几点探讨,为提高医学院校SAS软件实验课的教学效果提供参考。%SAS software experimental course is an important course about medical statistics, which is of great significance for students to master and apply the statistical method. According to characteristics of medical statistics SAS software, as well as problems in the educational process, the paper discusses the experimental course and hopes to improve the teach-ing effect of the SAS software.

  11. Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways.

    Science.gov (United States)

    Lai, Wan-Wen; Hsu, Shu-Chun; Chueh, Fu-Shih; Chen, Ya-Yin; Yang, Jai-Sing; Lin, Jing-Pin; Lien, Jin-Cherng; Tsai, Chung-Hung; Chung, Jing-Gung

    2013-05-01

    Quercetin, a principal flavanoid compound in onions, has been shown to possess a wide spectrum of pharmacological properties, including anticancer activities. Our earlier study showed that quercetin induced cytotoxic effects on SAS human oral cancer cells. In this study, we found that quercetin significantly reduced wound closure of SAS cells in culture plates after 12- and 24-h treatments. Results indicated that quercetin inhibited the expression and activity of matrix metalloproteinase (MMP)-2 and MMP-9, as measured by western blotting and gelatin zymography. The results from western blotting also showed that quercetin reduced the protein levels of MMP-2, -7, -9 and -10, vascular endothelial growth factor (VEGF), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) p65, inductible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), urokinase-type plasminogen activator (uPA), phosphatidylinositide-3 kinases (PI3K), nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IKBα), IKB-α/β, phosphorylated nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor kinase, alpha/beta (p-IKKα/β), focal adhesion kinase (FAK), son of sevenless homolog-1 (SOS1), growth factor receptor-bound protein-2 (GRB2), mitogen-activated protein kinase kinase kinase-3 (MEKK3), MEKK7, extracellular-signal-regulated kinase 1/2 (ERK1/2), p-ERK1/2, c-Jun N-terminal kinase 1/2 (JNK1/2), p38, p-p38, Jun proto-oncogene (c-JUN) and p-c-JUN but it did not affect Ras homolog gene family, member A (RhoA), Protein kinase C (PKC) and rat sarcoma viral oncogene homolog (RAS) in SAS cells. Confocal laser microscopy also showed that quercetin promoted the expressions of RhoA and Rho-associated, coiled-coil containing protein kinase-1 (ROCK1), but inhibited the expression of NF-κB p65 in SAS cells. It is concluded from these data that inhibition of migration and invasion of SAS cells by quercetin is associated with the down

  12. SAS продаёт свою долю Estonian Air / Герт Д. Ханкевиц

    Index Scriptorium Estoniae

    Ханкевиц, Герт Д.

    2009-01-01

    Majandusraskustes lennufirma SAS kavatseb loobuda osalustest kõigis lennufirmades, mis ei sobi kokku nende uue tegevuskavaga. Majandus- ja kommunikatsiooniminister Juhan Parts arvab, et riik peaks leidma Estonian Airile kodumaised partnerid

  13. Assessment of SFR reactor safety issues: Part II: Analysis results of ULOF transients imposed on a variety of different innovative core designs with SAS-SFR

    Energy Technology Data Exchange (ETDEWEB)

    Kruessmann, R., E-mail: regina.kruessmann@kit.edu [Karlsruhe Institute of Technology, Institute of Neutron Physics and Reactor Technology INR, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Ponomarev, A.; Pfrang, W.; Struwe, D. [Karlsruhe Institute of Technology, Institute of Neutron Physics and Reactor Technology INR, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Champigny, J.; Carluec, B. [AREVA, 10, rue J. Récamier, 69456 Lyon Cedex 06 (France); Schmitt, D.; Verwaerde, D. [EDF R& D, 1 avenue du général de Gaulle, 92140 Clamart (France)

    2015-04-15

    Highlights: • Comparison of different core designs for a sodium-cooled fast reactor. • Safety assessment with the code system SAS-SFR. • Unprotected Loss of Flow (ULOF) scenario. • Sodium boiling and core melting cannot be avoided. • A net negative Na void effect provides more grace time prior to local SA destruction. - Abstract: In the framework of cooperation agreements between KIT-INR and AREVA SAS NP as well as between KIT-INR and EDF R&D in the years 2008–2013, the evaluation of severe transient behavior in sodium-cooled fast reactors (SFRs) was investigated. In Part I of this contribution, the efficiency of newly conceived prevention and mitigation measures was investigated for unprotected loss-of-flow (ULOF), unprotected loss-of-heat-sink (ULOHS) and the unprotected transient-overpower (UTOP) transients. In this second part, consequence analyses were performed for the initiation phase of different unprotected loss-of-flow (ULOF) scenarios imposed on a variety of different core design options of SFRs. The code system SAS-SFR was used for this purpose. Results of analyses for cases postulating unavailability of prevention measures as shut-down systems, passive and/or active additional devices show that entering into an energetic power excursion as a consequence of the initiation phase of a ULOF cannot be avoided for those core designs with a cumulative void reactivity feedback larger than zero. However, even for core designs aiming at values of the void reactivity less than zero it is difficult to find system design characteristics which prevent the transient entering into partial core destruction. Further studies of the transient core and system behavior would require codes dedicated to specific aspects of transition phase analyses and of in-vessel material relocation analyses.

  14. Los efectivos del último ejército de la Persia Sasánida (572-642. Una solución desde las fuentes

    Directory of Open Access Journals (Sweden)

    Soto Chica, José

    2015-12-01

    Full Text Available The question of the number of troops that existed in the Sassanids’ armies during the 6th and 7th century has received various answers. Answers that, paradoxically, have not taken into account the specific and multiple information that provide the sources of this period. From our side in this paper, we address this question taking into account all the sources, whether these are Byzantine, Oriental, Persian or Perso-Islamic, and we try to show that the careful study of the data and the critical comparison permits us to evaluate with extreme precision the military power of the Sassanian Persia and to establish a comparative basis to shed new light on the late conflicts between Sassanid Persia and the Justinian’s or Heraclius’ Byzantium as well as those with the Arab armies of early Islam.La cuestión del número de efectivos con que contaron los ejércitos sasánidas de los siglos VI y VII ha recibido diferentes respuestas. Respuestas que, paradójicamente, no han tenido en cuenta las precisas y múltiples informaciones que al respecto proporcionan las fuentes del periodo. Por nuestra parte y en este trabajo, abordamos dicha cuestión teniendo en cuenta la totalidad de las fuentes, ya sean estas bizantinas, orientales, persas o persoislámicas y tratamos de mostrar que el atento estudio de los datos y su confrontación crítica, permite evaluar con suma precisión el poderío militar de la Persia sasánida y establecer así una base comparativa que arroje nueva luz sobre los últimos conflictos de la Persia sasánida con el Bizancio Justinianeo y Heraclida y con los ejércitos árabes del primer Islam.

  15. Smart substation is the further objective of SAS%智能变电站是变电站综合自动化的发展目标

    Institute of Scientific and Technical Information of China (English)

    黄益庄

    2013-01-01

    The main principle and idea of determining a development goal is proposed. Based on the development tendency of power network at home and abroad, the concept of “Smart Substation” is considered as the higher stage and further objective of technological development of SAS. The key point for “Smart Substation” lies in “intelligence”, i.e., to intelligentize different kinds of equipments in the substation. It should be a qualitative leap based on the realized functions of SAS. In smart substation, more attention should be paid on the technologies of switching on the distributed generation and realizing two-way interaction. The safety strategy of information management and storage is specially noticed. Many complicated key technologies need to be studied. Anyway,“Smart Substation” is a comprehensive system engineering. It is necessary to set a long term construction goal and planning.%  提出了确定建设目标需要考虑的主要原则和理念。根据国内外电网技术发展的趋势,论述了“智能变电站”是 SAS 技术发展的高级阶段和进一步发展的目标。“智能变电站”需要立足于一次和二次设备都实现智能化,必须在 SAS 已实现的功能的基础上有质的飞跃和扩展。对目前关于“智能变电站”建设过程中流传的一些模糊认识进行澄清。指出建设“智能变电站”有许多复杂的关键技术尚待解决,要充分重视分布式电源接入电网的相关技术的研究、要注意电力信息的科学管理和存储的安全策略等问题,是一项综合性、多学科的系统工程,需要制定长期发展的建设目标和规划。

  16. La SAS unipersonal y la empresa unipersonal de responsabilidad limitada-similitudes, diferencias, ventajas y proyección de ambas figuras dentro del ordenamiento mercantil colombiano

    OpenAIRE

    Adriana López

    2012-01-01

    La investigación consta de dos partes. La primera describe el marco regulatorio general de la Empresa Unipersonal y de la Sociedad por Acciones Simplificada (SAS) Unipersonal dentro del ordenamiento jurídico colombiano, haciendo énfasis en las similitudes, diferencias y ventajas de una figura sobre la otra, y la segunda parte hace una proyección de ambas figuras dentro del ordenamiento colombiano con base en las características, similitudes, diferencias y ventajas de la una sobre la otra, par...

  17. Planteamiento estratégico de Pronalfo S.A.S. y Reingeniería del Proceso de Producción

    OpenAIRE

    Fajardo Castillo, Erika Esperanza; Quiroga Arguello, Luz Andrea

    2012-01-01

    Pronalfo S.A.S es una empresa dedicada a la elaboración de núcleos balanceados como materia prima para la alimentación animal, fue creada hace 7 años y se encuentra en la etapa de crecimiento y posicionamiento en el mercado. Es necesario establecer el planeamiento estratégico mediante la definición de misión, visión, objetivos y estrategias, para tener clara su razón de ser y proyectándose al futuro estableciendo una ventaja competitiva mediante estrategias que le permitan mantenerse en ...

  18. Estudio de factibilidad para la prestación de asistencia técnica integral a motos en el Diagnosticentro S.A.S.

    OpenAIRE

    Acosta Chamorro, Darío Fernando

    2015-01-01

    El objetivo del presente trabajo es realizar una evaluación sobre la factibilidad de crear una nueva línea de negocio de asistencia técnica integral para motos en la empresa Diagnosticentro S.A.S., ubicada en la ciudad de Pereira -- Para ello se utiliza la metodología del modelo ONUDI, estableciendo una guía detallada acerca del proceso de planeación, que incluye: estudio del entorno mundial, nacional y local, estudio de mercado, técnico y administrativo, estudio legal y ambiental y evaluació...

  19. STUDIES ON HIBISCUS CANNABINUS, HIBISCUS SABDARIFFA, AND CANNABINUS SATIVA PULP TO BE A SUBSTITUTE FOR SOFTWOOD PULP- PART 2: SAS-AQ AND NSSC-AQ DELIGNIFICATION PROCESSES

    Directory of Open Access Journals (Sweden)

    Dharm Dutt

    2010-08-01

    Full Text Available Hibiscus cannabinus, Cannabis sativa, and Hibiscus sabdariffa, fast growing productive annual plants, could provide fiber necessary to partially alleviate the world’s fiber deficit. The present study aimed at producing high yield pulp and the best mechanical strength properties with minimum impact on environment by SAS-AQ, and NSSC-AQ pulping processes. A total alkali of 13% (as Na2O, an alkali ratio of 0.80, and a Na2SO3 charge 11.70% (as Na2O were found optimum to reduce maximum kappa number. A lower kappa number and good strength properties were achieved by increasing total alkali and Na2SO3 charge. SAS-AQ pulps showed good response towards CEHH bleaching. The NSSC-AQ pulping was conducted at a total alkali charge of 8% (as Na2O by varying the ratio of sulphite-to-carbonate (100:0-0:100, and cooking time (60-120 min at 1600C. A ratio of sulphite-to-carbonate 60:40 was suitable for corrugating medium (cooking time 60 min, while a ratio of sulphite-to-carbonate 70:30 showed better strength properties (longer cooking time.

  20. La SAS unipersonal y la empresa unipersonal de responsabilidad limitada-similitudes, diferencias, ventajas y proyección de ambas figuras dentro del ordenamiento mercantil colombiano

    Directory of Open Access Journals (Sweden)

    Adriana López

    2012-07-01

    Full Text Available La investigación consta de dos partes. La primera describe el marco regulatorio general de la Empresa Unipersonal y de la Sociedad por Acciones Simplificada (SAS Unipersonal dentro del ordenamiento jurídico colombiano, haciendo énfasis en las similitudes, diferencias y ventajas de una figura sobre la otra, y la segunda parte hace una proyección de ambas figuras dentro del ordenamiento colombiano con base en las características, similitudes, diferencias y ventajas de la una sobre la otra, para llegar a la conclusión de que la utilización de la empresa unipersonal disminuirá progresivamente hasta desaparecer de la práctica jurídica colombiana, para ser remplazada por la utilización de la SAS unipersonal la cual detenta las características principales de la empresa unipersonal pero la supera al tener todas las ventajas implícitas de la sociedad por acciones simplificada.

  1. La SAS unipersonal y la empresa unipersonal de responsabilidad limitada-similitudes, diferencias, ventajas y proyección de ambas figuras dentro del ordenamiento mercantil colombiano

    Directory of Open Access Journals (Sweden)

    Adriana López

    2012-06-01

    Full Text Available La investigación consta de dos partes. La primera describe el marco regulatorio general de la Empresa Unipersonal y de la Sociedad por Acciones Simplificada (SAS Unipersonal dentro del ordenamiento jurídico colombiano, haciendo énfasis en las similitudes, diferencias y ventajas de una figura sobre la otra, y la segunda parte hace una proyección de ambas figuras dentro del ordenamiento colombiano con base en las características, similitudes, diferencias y ventajas de la una sobre la otra, para llegar a la conclusión de que la utilización de la empresa unipersonal disminuirá progresivamente hasta desaparecer de la práctica jurídica colombiana, para ser remplazada por la utilización de la SAS unipersonal la cual detenta las características principales de la empresa unipersonal pero la supera al tener todas las ventajas implícitas de la sociedad por acciones simplificada.

  2. sas profesionālās lomas pacientu baiļu mazināšanā

    OpenAIRE

    Ivanova, Laura

    2016-01-01

    Bakalaura darba tēma: “Māsas profesionālās lomas pacientu baiļu mazināšanā”. Tēmas aktualitāti nosaka fakts, ka mūsdienās sabiedrība ļoti bieži izjūt bailes un stresu, tāpēc ir svarīgi noskaidrot māsu lomas gan māsu, gan pacientu skatījumā, lai turpmāk māsu sniegtā aprūpe tiktu orientēta uz katra konkrēta pacienta vajadzībām un baiļu mazināšanu. Darba mērķis ir noskaidrot māsas profesionālās lomas pacientu baiļu mazināšanā māsu un pacientu skatījumā. Pētniecības uzdevumi ir: 1.Analizēt lit...

  3. 基于SAS的Web使用日志用户聚类分析%User Cluster Analysis of Web Usages Logs Based on SAS

    Institute of Scientific and Technical Information of China (English)

    欧阳烽

    2013-01-01

    The user cluster Analysis of Web Usages Logs based on SAS is the data of Web Usages Logs for data conversion, get-ting the user transaction table which is pre-formed after the handling of the corresponding data, then making the user cluster anal-ysis through the SAS data mining tools. Digital resources are reasonably procured and managed according to the demands of dif-ferent users on digital resources. Personalized services can be provided for different users.%基于SAS的Web使用日志用户聚类分析,即通过SAS数据挖掘工具将由Web使用日志数据经过数据转换和数据预处理后形成的用户事务表数据运用不同的方法进行聚类分析,以达到根据不同类别用户的需求对数字资源进行合理的采购和管理,为用户提供个性化服务的目的。

  4. Re-examining the role of Drosophila Sas-4 in centrosome assembly using two-colour-3D-SIM FRAP.

    Science.gov (United States)

    Conduit, Paul T; Wainman, Alan; Novak, Zsofia A; Weil, Timothy T; Raff, Jordan W

    2015-11-04

    Centrosomes have many important functions and comprise a 'mother' and 'daughter' centriole surrounded by pericentriolar material (PCM). The mother centriole recruits and organises the PCM and templates the formation of the daughter centriole. It has been reported that several important Drosophila PCM-organising proteins are recruited to centrioles from the cytosol as part of large cytoplasmic 'S-CAP' complexes that contain the centriole protein Sas-4. In a previous paper (Conduit et al., 2014b) we showed that one of these proteins, Cnn, and another key PCM-organising protein, Spd-2, are recruited around the mother centriole before spreading outwards to form a scaffold that supports mitotic PCM assembly; the recruitment of Cnn and Spd-2 is dependent on another S-CAP protein, Asl. We show here, however, that Cnn, Spd-2 and Asl are not recruited to the mother centriole as part of a complex with Sas-4. Thus, PCM recruitment in fly embryos does not appear to require cytosolic S-CAP complexes.

  5. Cerebral scintigraphy by {sup 99m}Tc-HMPAO in sleep apnea syndromes (SAS) during the wakeful state; Scintigraphie cerebrale au Tc99m-HMPAO dans les syndromes d`apnees du sommeil (SAS) pendant l`etat de veille

    Energy Technology Data Exchange (ETDEWEB)

    Tainturier, C.; Benamor, M.; Hausser-Hauw, C.; Rakotonanahary, D.; Fleury, B. [CMC FOCH 92150 SURESNES (France)

    1997-12-31

    The SAS is associated to cerebral hemodynamic modifications and to a high frequency of cerebro-vascular accidents. The aim of this study was to verify, during wakeful state, the cerebral hemodynamic in 14 patients afflicted with SAS of various intensity (Apnea Index = 5-120/h). 555 MBq of {sup 99m}Tc-HMPAO were injected in patients maintained awake. The images were obtained 20 minutes after injection by mean of a double-head chamber equipped with fan-beam collimators. They were interpreted visually by two independent readers. Anomalies of cerebral fixation were observed in 12/14 patients. They were small sores of diffuse hypo-fixations, with a `riddly` aspect (4 cases), sores of bi-temporal hypo-fixation with a right- or left- hemispheric predominance (6 cases), or right fronto-temporal hypo-fixations (2 cases). The cerebral fixation anomalies were reported in the SASs. Ficker et al (1997) have shown in-sleep frontal hypo-perfusions in 5/14 apneic patients, reversible under continuous positive airing pressure (CPAP). In conclusion, anomalies of cerebral fixation exist in SAS-carrying patients, even in the wakeful state. Questions about hypoperfusion, pre-lacunar syndrome, atrophy still remain. A check of this study is planned after the CPAP treatment to determine the hemodynamic or anatomic origin and the anomaly reversibility

  6. Efficacy of Phase 3 Trial of RTS, S/AS01 Malaria Vaccine in infants: a systematic review and meta-analysis.

    Science.gov (United States)

    Mahmoudi, Shima; Keshavarz, Hossein

    2017-01-06

    Although vaccines would be the ideal tool for control, prevention, elimination, and eradication of many infectious diseases, developing of parasites vaccines such as malaria vaccine is very complex. The most advanced malaria vaccine candidate is RTS,S, a pre-erythrocytic vaccine for which pivotal phase III trial design is underway. Few recent malaria vaccine review articles have attempted to outline of all clinical trials that have occurred globally and no meta-analysis was performed on efficacy of Phase 3 Trial of RTS, S/AS01 Malaria vaccine up to now in infants. Therefore, a systematic review and meta-analysis was carried out to review new and existing data on efficacy of Phase 3 Trial of RTS, S/AS01 Malaria Vaccine in infants. The electronic databases searched were Pubmed (1965-present) and Web of Science (1970-present) (Search date: May, 2016). After full-text review of the papers evaluating clinical/severe malaria in several well-designed phase III field efficacy trials, 5 were determined to meet the eligibility criteria for inclusion in the systematic review. Four out of the 5 publications dealing with efficacy of Phase 3 Trial of RTS, S/AS01 malaria vaccine were included in the qualitative analysis. Pooled estimate of vaccine efficacy in clinical and severe malaria in children aged 5-17 mo was 29% (95% CL: 19%-46%) and 39% (95% CI 20%-74%), while this estimate vaccine in clinical and severe malaria in children aged 6-12 mo was 19% (95% CI 14%-24%) and 21 (95% CI 19%-37%), respectively. On the other hand, higher VE was seen in both per- protocol and intention-to-treat population in children aged 5-17 than the children aged 6-12 mo. The results of this meta-analysis suggest that this candidate malaria vaccine has relatively little efficacy, and the vaccine apparently will not meet the goal of malaria eradication by itself.

  7. Groundwater contamination in the basement-complex area of Ile-Ife, southwestern Nigeria: A case study using the electrical-resistivity geophysical method

    Science.gov (United States)

    Adepelumi, A. A.; Ako, B. D.; Ajayi, T. R.

    2001-11-01

    Hydrogeoenvironmental studies were carried out at the sewage-disposal site of Obafemi Awolowo University campus, Ile-Ife, Nigeria. The objective of the survey was to determine the reliability of the electrical-resistivity method in mapping pollution plumes in a bedrock environment. Fifty stations were occupied with the ABEM SAS 300C Terrameter using the Wenner array. The electrical-resistivity data were interpreted by a computer-iteration technique. Water samples were collected at a depth of 5.0 m in 20 test pits and analyzed for quality. The concentrations of Cr, Cd, Pb, Zn, and Cu are moderately above the World Health Organization recommended guidelines. Plumes of contaminated water issuing from the sewage ponds were delineated. The geoelectric sections reveal four subsurface layers, with increasing depth, lateritic clay, clayey sand/sand, and weathered/fractured bedrock, and fresh bedrock. The deepest layers, 3 and 4, constitute the main aquifer, which has a thickness of 3.1-67.1 m. The distribution of the elements in the sewage effluent confirms a hydrological communication between the disposal ponds and groundwater. The groundwater is contaminated, as shown by sampling and the geophysical results. Thus, the results demonstrate the reliability of the direct-current electrical-resistivity geophysical method in sensing and mapping pollution plumes in a crystalline bedrock environment. Résumé. Des études géo-environnementales ont été réalisées sur le site d'épandages du campus universitaire d'Obafemi Awolowo, à Ile-Ife (Nigeria). L'objectif de ce travail était de déterminer la fiabilité de la méthode des résistivités électriques pour cartographier les panaches de pollution dans un environnement de socle. Cinquante stations ont été soumises à mesures au moyen d'un ABEM SAS 300C Terrameter en utilisant le dispositif de Wenner. Les données de résistivité électrique ont été interprétées au moyen d'une technique de calcul itérative. Des

  8. 变电站通信标准向IEC 61850的过渡%Transfering of SAS Communication to IEC 61850 Standard

    Institute of Scientific and Technical Information of China (English)

    肖丽萍; 房同忠

    2006-01-01

    IEC 61850是"变电站通信网络和系统"的系列国际标准,代表了变电站自动化系统(SAS)的最新发展方向.目前广泛应用的变电站通信协议主要是IEC 60870-5-103,因此如何从该协议逐步过渡到IEC 61850是一个现实的课题.本文简要分析了IEC 61850和原有协议之间的异同,并以IEC 60870-5-103规约向IEC 61850标准过渡的一个实例,提出了一种过渡期的解决方法.

  9. SAS-2 gamma-ray results from the galactic plane and their implications for galactic structure and galactic cosmic-ray dynamics

    Science.gov (United States)

    Fichtel, C. E.; Kniffen, D. A.; Thompson, D. J.

    1977-01-01

    The final SAS-2 results related to high energy galactic gamma-ray emission show a strong correlation with galactic structural features seen at other wavelenghts, when the known gamma-ray sources are subtracted. Theoretical considerations and analysis of the gamma-ray data suggest that the galactic cosmic rays are dynamically coupled to the interstellar matter through the magnetic fields, and hence the cosmic ray density is enhanced where the matter density is greatest on the scale of the galactic arms. This concept has been explored in a galactic model that assumes: (1) cosmic rays are galactic and not universal; (2)on the scale of the galactic arms, the cosmic ray column (surface) density is proportional to the total interstellar gas column density; (3)the cosmic ray scale height is significantly larger than the scale height to the matter; and (4) ours is a spiral galaxy characterized by an arm to interarm density ratio of over 2:1.

  10. SAS在辐射剂量-效应研究中的应用%Application of SAS in the study on radiation dose-effect

    Institute of Scientific and Technical Information of China (English)

    刘长安

    2001-01-01

    简述辐射剂量-效应研究中常用的13种数学模型。应用SAS 6.12 for windows统计软件包编写的程序可以方便、快捷地实现辐射剂量-效应曲线的拟合并筛选出最佳的数学模型。%Thirteen mathematical models usually used in study on radiation dose-effect are described in this paper.Radiation dose-effect curve can be fitted conveniently and quickly and an optimal mathematical model for it can be selected with computer programs programmed with Statistical Analysis System(SAS)software package,version 6.12 for windows.

  11. Fibrinogen species as resolved by HPLC-SAXS data processing within the UltraScan Solution Modeler (US-SOMO) enhanced SAS module.

    Science.gov (United States)

    Brookes, Emre; Pérez, Javier; Cardinali, Barbara; Profumo, Aldo; Vachette, Patrice; Rocco, Mattia

    2013-12-01

    Fibrinogen is a large heterogeneous aggregation/degradation-prone protein playing a central role in blood coagulation and associated pathologies, whose structure is not completely resolved. When a high-molecular-weight fraction was analyzed by size-exclusion high-performance liquid chromatography/small-angle X-ray scattering (HPLC-SAXS), several composite peaks were apparent and because of the stickiness of fibrinogen the analysis was complicated by severe capillary fouling. Novel SAS analysis tools developed as a part of the UltraScan Solution Modeler (US-SOMO; http://somo.uthscsa.edu/), an open-source suite of utilities with advanced graphical user interfaces whose initial goal was the hydrodynamic modeling of biomacromolecules, were implemented and applied to this problem. They include the correction of baseline drift due to the accumulation of material on the SAXS capillary walls, and the Gaussian decomposition of non-baseline-resolved HPLC-SAXS elution peaks. It was thus possible to resolve at least two species co-eluting under the fibrinogen main monomer peak, probably resulting from in-column degradation, and two others under an oligomers peak. The overall and cross-sectional radii of gyration, molecular mass and mass/length ratio of all species were determined using the manual or semi-automated procedures available within the US-SOMO SAS module. Differences between monomeric species and linear and sideways oligomers were thus identified and rationalized. This new US-SOMO version additionally contains several computational and graphical tools, implementing functionalities such as the mapping of residues contributing to particular regions of P(r), and an advanced module for the comparison of primary I(q) versus q data with model curves computed from atomic level structures or bead models. It should be of great help in multi-resolution studies involving hydrodynamics, solution scattering and crystallographic/NMR data.

  12. Process optimization studies of 10-Hydroxycamptothecin (HCPT)-loaded folate-conjugated chitosan nanoparticles by SAS-ionic crosslink combination using response surface methodology (RSM)

    Science.gov (United States)

    Zhao, Xiuhua; Jiang, Ru; Zu, Yuangang; Wang, Ying; Zhao, Qi; Zu, Baishi; Zhao, Dongmei; Wang, Meixiang; Sun, Zhiqiang

    2012-01-01

    10-Hydroxycamptothecin (HCPT) is a well-established topoisomerase I inhibitor of a broad spectrum of cancers. However, poor aqueous solubility, low instability, and toxicity to normal tissues have limited its clinical development. A novel HCPT-containing drug carrier system was developed to overcome these disadvantages. The response surface methodology was used to optimize the process of preparing HCPT-chitosan nanoparticles (HCPT-CSNPs) by the SAS-ionic crosslink (supercritical antisolvent SAS) combination method; the resulting HCPT-CSNPs were then conjugated with folate for specific targeting. A central composite design, composed of four independent variables, namely, chitosan concentration, TPP concentration, HCPT nanoparticle concentration, and crosslink time, was applied in the modeling process. The mean particle size and drug entrapment efficiency (DEE) of HCPT-CSNPs were chosen as response variables. The interactive effects of the four independent variables on the response variables were also studied. Nanoparticle characteristics such as morphology, DEE, and mean particle size were investigated. The optimum conditions for preparing HCPT-CSNPs were determined as follows: folate-coupled chitosan concentration 2.46 mg/ml, TPP concentration 7.73 mg/ml, HCPT nanoparticle concentration 0.48 mg/ml, and crosslinking time 47.4 min. Optimum conditions for preparing desired HCPT-CSNPs with a mean particle size of 173.5 nm and entrapment efficiency of 77.3% were obtained. The resulting folate-conjugated HCPT-CSNPs (FA-HCPT-CSNPs) reveal that the amount of folate conjugation was 197.64 mg/g CS. FA-HCPT-CSNPs used in drug carrier systems could have potential value in HCPT-sensitive tumors.

  13. Effect of cell cycle phase on the sensitivity of SAS cells to sonodynamic therapy using low-intensity ultrasound combined with 5-aminolevulinic acid in vitro.

    Science.gov (United States)

    Li, Nan; Sun, Miao; Wang, Yao; Lv, Yanhong; Hu, Zheng; Cao, Wenwu; Zheng, Jinhua; Jiao, Xiaohui

    2015-08-01

    Sonodynamic therapy (SDT) with 5-aminolevulinic acid (5-ALA) can effectively inhibit various types of tumor in vitro and in vivo. However, the association between the efficacy of SDT and the phase of the cell cycle remains to be elucidated. 5-ALA may generate different quantities of sonosensitizer, protoporphyrin IX (PpIX), in different phases of the cell cycle, which may result in differences in sensitivity to 5-ALA-induced SDT. The present study aimed to investigate the effect of the cell cycle on the susceptibility of SAS cells to SDT following synchronization to different cell cycle phases. These results indicates that the rates of cell death and apoptosis of the SAS cells in the S and G2/M phases were significantly higher following SDT, compared with those in the G1-phase cells and unsynchronized cells, with a corresponding increase in PpIX in the S and G2/M cells. In addition, the expression of caspase-3 increased, while that of B-cell lymphoma (Bcl)-2 decreased markedly in theS and G2/M cells following SDT. Cyclin A was also expressed at higher levels in the S and G2/M cells, compared with the G1-phase cells. SDT also caused a significant upregulation of cyclin A in all phases of the cell cycle, however this was most marked in the S and G2/M cells. It was hypothesized that high expression levels of cyclin A in the S and G2/M cells may promote the induction of caspase-3 and reduce the induction of Bcl-2 by SDT and, therefore, enhance apoptosis. Taken together, these data demonstrated that cells in The S and G2/M phases generate more intracellular PpIX, have higher levels of cyclin A and are, therefore, more sensitive to SDT-induced cytotoxicity. These findings indicate the potential novel approach to preventing the onset of cancer by combining cell-cycle regulators with SDT. This sequential combination therapy may be a simple and cost-effective way of enhancing the effects of SDT in clinical settings.

  14. Hotell Radisson SAS = Radisson SAS Hotel / Inga Raukas

    Index Scriptorium Estoniae

    Raukas, Inga, 1967-

    2001-01-01

    Projekteerija Arhitektuuribüroo Künnapu & Padrik. Arhitektid Vilen Künnapu, Ain Padrik, Eero Palm, Tarmo Maiste. Sisekujundajad Christian Lundwall, Jan Öberg. Konstruktsioonid: Teuvo Meriläinen, Jyrki Rautamäki. Projekt ja hotell valmis 2000. 12 ill.: korruste plaanid, sise- ja välisvaated

  15. Hotell Radisson SAS = Radisson SAS Hotel / Inga Raukas

    Index Scriptorium Estoniae

    Raukas, Inga, 1967-

    2001-01-01

    Projekteerija Arhitektuuribüroo Künnapu & Padrik. Arhitektid Vilen Künnapu, Ain Padrik, Eero Palm, Tarmo Maiste. Sisekujundajad Christian Lundwall, Jan Öberg. Konstruktsioonid: Teuvo Meriläinen, Jyrki Rautamäki. Projekt ja hotell valmis 2000. 12 ill.: korruste plaanid, sise- ja välisvaated

  16. Study on SAS image segmentation using SVM based on statistical and texture features%基于统计和纹理特征的SAS图像SVM分割研究

    Institute of Scientific and Technical Information of China (English)

    陈强; 田杰; 黄海宁; 张春华

    2013-01-01

    Synthetic aperture sonar (SAS) images can effectively describe the topography,geomorphology and substrate of seabed;however,one single SAS image usually corresponds to a larger area ;so it is necessary to segment the SAS image into different regions according to certain property,which benefits further analyzing the image,and detecting and identifying the target.Study found that SAS images of different substrates have different statistical and texture features;in this paper,the statistical properties,such as the mean,standard deviation and kurtosis of the grey level histogram,as well as the texture features,such as the energy,correlation,contrast and entropy of the grey level co-occurrence matrix are selected and used to describe different regions of the SAS image.These selected features are used as the support vector machine (SVM) training characteristics and the classifier is obtained for the SAS image segmentation.The experiment results show that the proposed SVM algorithm is a good segmentation method for the region segmentation of SAS image.%合成孔径声呐图像可以有效反映海底的地形、地貌和底质等情况,但是单幅SAS图像通常对应一片较大的区域,需要按照某种性质将不同性质的区域分割开来,以有利于下一步的图像分析以及目标检测和识别.研究发现,不同底质区域的SAS图像具有不同的统计和纹理特征,选取灰度直方图的均值、标准差、峰度等统计特性和灰度共生矩阵的能量、相关性、对比度、熵值等纹理特性用以描述SAS图像的不同区域.将选取的特征作为SVM的训练特征,进而得到SVM分类器,用于SAS图像分割.实验结果表明,SVM算法可以很好地对SAS图像进行区域分割.

  17. 采用Vernier阵技术的SAS图像重建%Image Reconstruction for Synthetic Aperture Sonar (SAS) System with Vernier Array Technique

    Institute of Scientific and Technical Information of China (English)

    蒋小奎; 孙超; 冯杰

    2005-01-01

    在采用Vernier阵技术时,为了避免由于等效相位中心(DPC)近似而引起的合成孔径声纳(SAS)图像模糊,提出一种新的数据处理方法,该方法根据收发分置成像的几何特性,采用修正的距离-多普勒算法对单个接收元信号独立进行合成孔径处理,并将独立处理产生的所有图像相干叠加,得到SAS系统的高分辨图像.对DPC近似处理、单个接收元合成孔径处理以及相干叠加处理的计算机仿真结果进行了比较,结果验证了该处理方法的可行性和有效性,并且进一步验证了Vernier阵技术的高分辨特性.

  18. SAS-2 observations of the diffuse gamma radiation in the galactic latitude interval from 10 to 90 deg in both hemispheres

    Science.gov (United States)

    Fichtel, C. E.; Hartman, R. C.; Kniffen, D. A.; Thompson, D. J.; Ogelman, H. B.; Ozel, M. E.; Tumer, T.

    1977-01-01

    An analysis of all the second Small Astronomy Satellite (SAS-2) gamma-ray data for galactic latitudes higher than 10 deg in both hemispheres has shown that the intensity varies with galactic latitude, being larger near 10 deg than 90 deg. For energies above 100 MeV the gamma-ray data are consistent with a latitude distribution of the form I(b) = C1 + C2/sin b, with the second term being dominant. This result suggests that the radiation above 100 MeV is coming largely from local regions of the galactic disk. Between 35 and 100 MeV, a similar equation is also a good representation of the data, but here the two terms are comparable. These results indicate that the diffuse radiation above 35 MeV consists of two parts, one with a relatively hard galactic component and the other an isotropic steep spectral component which extrapolates back well to the low-energy (less than 10 MeV) diffuse radiation. The steepness of the diffuse isotropic component places significant constraints on possible theoretical models of this radiation.

  19. Gypenosides inhibits migration and invasion of human oral cancer SAS cells through the inhibition of matrix metalloproteinase-2 -9 and urokinase-plasminogen by ERK1/2 and NF-kappa B signaling pathways.

    Science.gov (United States)

    Lu, Kung-Wen; Chen, Jung-Chou; Lai, Tung-Yuan; Yang, Jai-Sing; Weng, Shu-Wen; Ma, Yi-Shih; Lu, Pei-Jung; Weng, Jing-Ru; Chueh, Fu-Shin; Wood, W Gibson; Chung, Jing-Gung

    2011-05-01

    Gypenosides (Gyp), found in Gynostemma pentaphyllum Makino, has been used as a folk medicine in the Chinese population for centuries and is known to have diverse pharmacologic effects, including anti-proliferative and anti-cancer actions. However, the effects of Gyp on prevention from invasion and migration of oral cancer cells are still unsatisfactory. The purpose of this study was to investigate effects of Gyp treatment on migration and invasion of SAS human oral cancer cells. SAS cells were cultured in the presence of 90 and 180 μg/mL Gyp for 24 and 48 hours. Gyp induced cytotoxic effects and inhibited SAS cells migration and invasion in dose- and time-dependent response. Wound-healing assay and boyden chamber assay were carried out to investigate Gyp-inhibited migration and invasion of SAS cells. Gyp decreased the abundance of several proteins, including nuclear factor-kappa B (NF-κB), cyclooxygenase-2 (COX-2), extracellular signal-regulated kinase 1/2 (ERK1/ 2), matrix metalloproteinase-9, -2 (MMP-9, -2), sevenless homolog (SOS), Ras, urokinase-type plasminogen activator (uPA), focal adhesion kinase (FAK) and RAC-alpha serine/threonine-protein kinase (Akt), in a time-dependent manner. In addition, Gyp decreased mRNA levels of MMP-2, MMP-7, MMP-9 but did not affect FAK and Rho A mRNA levels in SAS cells. These results provide evidences for the role of Gyp as a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of oral cancer cells. The inhibition of NF-κB and MMP-2, -7 and -9 signaling may be one of the mechanisms that is present in Gyp-inhibited cancer cell invasion and migration.

  20. Multilevel models applications using SAS

    CERN Document Server

    Wang, Jichuan; Fisher, James F

    2011-01-01

    This book covers a broad range of topics about multilevel modeling. The goal is to help readers to understand the basic concepts, theoretical frameworks, and application methods of multilevel modeling. It is at a level also accessible to non-mathematicians, focusing on the methods and applications of various multilevel models and using the widely used statistical software SAS®. Examples are drawn from analysis of real-world research data.

  1. Multilevel Models Applications Using SAS

    CERN Document Server

    Wang, Jichuan; Fisher, James

    2011-01-01

    This book covers a broad range of topics about multilevel modeling. The goal is to help readersto understand the basic concepts, theoretical frameworks, and application methods of multilevel modeling. Itis at a level also accessible to non-mathematicians, focusing on the methods and applications of various multilevel models and using the widely used statistical software SAS®.Examples are drawn from analysis of real-world research data.

  2. Laborsalud S.A.S.

    OpenAIRE

    2013-01-01

    Crear una empresa prestadora de servicios integrales en salud ocupacional basados en la legislación vigente y enfocada a la satisfacción de las necesidades de los clientes, que brinde un valor agregado como expertos con un sistema de resultados en línea a través de su página web y amplio portafolio que integre los requerimientos en materia de salud ocupacional y seguridad industrial de las empresas.

  3. Radisson SAS tutvustab noori kunstnikke

    Index Scriptorium Estoniae

    2006-01-01

    Näitusest hotelli konverentsikeskuses, millega tähistatakse noorte eesti kunstnike loomingut eksponeeriva internetikunstigalerii Globeart loomist. Eksponeeritakse Paul Sontagi, Rauno Thomas Mossi jt. kunstnike töid

  4. Development of standardized laboratory methods and quality processes for a phase III study of the RTS, S/AS01 candidate malaria vaccine

    Directory of Open Access Journals (Sweden)

    Carter Terrell

    2011-08-01

    Full Text Available Abstract Background A pivotal phase III study of the RTS,S/AS01 malaria candidate vaccine is ongoing in several research centres across Africa. The development and establishment of quality systems was a requirement for trial conduct to meet international regulatory standards, as well as providing an important capacity strengthening opportunity for study centres. Methods Standardized laboratory methods and quality assurance processes were implemented at each of the study centres, facilitated by funding partners. Results A robust protocol for determination of parasite density based on actual blood cell counts was set up in accordance with World Health Organization recommendations. Automated equipment including haematology and biochemistry analyzers were put in place with standard methods for bedside testing of glycaemia, base excess and lactacidaemia. Facilities for X-rays and basic microbiology testing were also provided or upgraded alongside health care infrastructure in some centres. External quality assurance assessment of all major laboratory methods was established and method qualification by each laboratory demonstrated. The resulting capacity strengthening has ensured laboratory evaluations are conducted locally to the high standards required in clinical trials. Conclusion Major efforts by study centres, together with support from collaborating parties, have allowed standardized methods and robust quality assurance processes to be put in place for the phase III evaluation of the RTS, S/AS01 malaria candidate vaccine. Extensive training programmes, coupled with continuous commitment from research centre staff, have been the key elements behind the successful implementation of quality processes. It is expected these activities will culminate in healthcare benefits for the subjects and communities participating in these trials. Trial registration Clinicaltrials.gov NCT00866619

  5. Synthesis and Evaluation of Water Soluble MA/SAS Polymer Scale Inhibitor%MA/SAS水溶性聚合物阻垢剂的合成与评价

    Institute of Scientific and Technical Information of China (English)

    王忠辉; 刘庆旺

    2005-01-01

    以马来酸酐(MA)和烯丙基磺酸钠(SAS)为原料,制得MA/SAS水溶性聚合物阻垢剂.确定了最佳工艺条件:n(MA):n(SAS)=1:1,体系pH值4.0~4.5,反应温度75~80℃,反应时间4~5 h.MA/SAS水溶性聚合物阻垢性能优于现在常用的阻垢剂HEDP,并与其他油田常用药剂具有良好的配伍性.在现场试验中,MA/SAS聚合物阻垢剂阻垢率可达90%,效果明显.

  6. Sleep-disordered breathing in acute ischemic stroke and transient ischemic attack: effects on short- and long-term outcome and efficacy of treatment with continuous positive airways pressure--rationale and design of the SAS CARE study.

    Science.gov (United States)

    Cereda, Carlo W; Petrini, Liliane; Azzola, Andrea; Ciccone, Alfonso; Fischer, Urs; Gallino, Augusto; Györik, Sandor; Gugger, Matthias; Mattis, Johannes; Lavie, Lena; Limoni, Costanzo; Nobili, Lino; Manconi, Mauro; Ott, Sebastian; Pons, Marco; Bassetti, Claudio L

    2012-10-01

    Sleep-disordered breathing represents a risk factor for cardiovascular morbidity and mortality and negatively affects short-term and long-term outcome after an ischemic stroke or transient ischemic attack. The effect of continuous positive airways pressure in patients with sleep-disordered breathing and acute cerebrovascular event is poorly known. The SAS CARE 1 study assesses the effects of sleep-disordered breathing on clinical evolution, vascular functions, and markers within the first three-months after an acute cerebrovascular event. The SAS CARE 2 assesses the effect of continuous positive airways pressure on clinical evolution, cardiovascular events, and mortality as well as vascular functions and markers at 12 and 24 months after acute cerebrovascular event. SAS CARE 1 is an open, observational multicenter study in patients with acute cerebrovascular event acutely admitted in a stroke unit: a sample of 200 acute cerebrovascular event patients will be included. Vascular functions and markers (blood pressure, heart rate variability, endothelial function by peripheral arterial tonometry and specific humoral factors) will be assessed in the acute phase and at three-months follow-up. SAS CARE 2 will include a sample of patients with acute cerebrovascular event in the previous 60-90 days. After baseline assessments, the patients will be classified according to their apnea hypopnea index in four arms: non-sleep-disordered breathing patients (apnea hypopnea index acute cerebrovascular event and the feasibility/efficacy of continuous positive airways pressure treatment in selected patients with acute cerebrovascular event and sleep-disordered breathing. © 2012 The Authors. International Journal of Stroke © 2012 World Stroke Organization.

  7. The Risk Factors Affecting and the Influence on the QOL of Patients with SAS%老年SAS患者生存质量及其影响因素分析

    Institute of Scientific and Technical Information of China (English)

    鲁丹

    2011-01-01

    Objective:To explore the risk factors affecting the quality of life(QOL)of patients with obstructive sleep apnea (SAS).Methods:Measuring the quality of life of 150 patients suffered from SAS with WHO QOL-BREF and analyzing the influences of the sleepiness, quality of sleep.Results:The scores on physical domain and psychological domain of patients were less than that of normal person.Conclusions: The sleepiness quality of sleep can affect the QOL of patients with SAS.%目的:探讨老年睡眠呼吸暂停综合征(SAS)患者生存质量及其影响因素.方法:采用WHOQOL-BREF生存质量量表对150例SAS患者进行生存质量测评,并进一步比较嗜睡、睡眠质量对患者生存质量的影响.结果:SAS患者质量评分较低,生理领域评分最低.社会因素、医学因素、自我评价对生存质量影响有显著性意义.SAS组生存质量生理领域、心理领域得分低于健康对照,SAS组内嗜睡组低于不嗜睡组、睡眠质量差组低于睡眠质量好组(P均<0.05).结论:SAS患者的嗜睡、低睡眠质量及慢性病是影响生活质量的因素.

  8. Behavior of an heterogeneous annular FBR core during an unprotected loss of flow accident: Analysis of the primary phase with SAS-SFR

    Energy Technology Data Exchange (ETDEWEB)

    Massara, S.; Schmitt, D.; Bretault, A.; Lemasson, D.; Darmet, G.; Verwaerde, D. [EDF R and D, 1, Avenue du General de Gaulle, 92141 Clamart (France); Struwe, D.; Pfrang, W.; Ponomarev, A. [Karlsruher Institut fuer Technologie KIT, Institut fuer Neutronenphysik und Reaktortechnik INR, Hermann-von-Helmholtz-Platz 1, Gebaude 521, 76344 Eggenstein-Leopoldshafen (Germany)

    2012-07-01

    In the framework of a substantial improvement on FBR core safety connected to the development of a new Gen IV reactor type, heterogeneous core with innovative features are being carefully analyzed in France since 2009. At EDF R and D, the main goal is to understand whether a strong reduction of the Na-void worth - possibly attempting a negative value - allows a significant improvement of the core behavior during an unprotected loss of flow accident. Also, the physical behavior of such a core is of interest, before and beyond the (possible) onset of Na boiling. Hence, a cutting-edge heterogeneous design, featuring an annular shape, a Na-plena with a B{sub 4}C plate and a stepwise modulation of fissile core heights, was developed at EDF by means of the SDDS methodology, with a total Na-void worth of -1 $. The behavior of such a core during the primary phase of a severe accident, initiated by an unprotected loss of flow, is analyzed by means of the SAS-SFR code. This study is carried-out at KIT and EDF, in the framework of a scientific collaboration on innovative FBR severe accident analyses. The results show that the reduction of the Na-void worth is very effective, but is not sufficient alone to avoid Na-boiling and, hence, to prevent the core from entering into the primary phase of a severe accident. Nevertheless, the grace time up to boiling onset is greatly enhanced in comparison to a more traditional homogeneous core design, and only an extremely low fraction of the fuel (<0.1%) enters into melting at the end of this phase. A sensitivity analysis shows that, due to the inherent neutronic characteristics of such a core, the gagging scheme plays a major role on the core behavior: indeed, an improved 4-zones gagging scheme, associated with an enhanced control rod drive line expansion feed-back effect, finally prevents the core from entering into sodium boiling. This major conclusion highlights both the progress already accomplished and the need for more detailed

  9. 应用SAS软件宏命令实现二分类数据的Meta分析%Application of SAS software macros for realizing Meta-analysis of two-category data

    Institute of Scientific and Technical Information of China (English)

    鄢金柱; 李胜; 翁鸿; 曾宪涛

    2014-01-01

    SAS system is considered as one of international standard software systems in the field of data processing and statistics, however, it required the user has higher capability due to its complex and difficult programming. For well applying SAS for conducting a Meta-analysis, Stephen Senna and his colleagues developed a suite of macros for the Meta-analysis of binary data. These macros will realize the Meta-analysis of binary data conveniently and can generate the forest plot, funnel plot, Galbraith plot, Q-Q plot and other graphs. The authors introduced in the paper how to use these SAS macros for conducting the Meta-analysis of binary data.%SAS被誉为国际上数据处理和统计分析领域的标准软件系统,但其程序编写复杂且难度较大,对使用者的要求较高。为了更好的使用SAS软件实现Meta分析,Stephen Senna等人编写了一套专用于二分类资料的Meta分析的宏命令。这套宏语言可以方便的实现Meta分析,绘制森林图、漏斗图、加尔布雷斯图、Q-Q正态分布图等图形。本文结合实例对应用SAS宏语言实现二分类数据Meta分析的方法进行详细介绍。

  10. Carbon Fibers: Reexamination of the Critical Low-Temperature (200-300C) Stabilization of Polyacrylonitrile,

    Science.gov (United States)

    CARBON FIBERS , SYNTHESIS(CHEMISTRY)), (*ACRYLONITRILE POLYMERS, CARBON FIBERS ), SHEETS, CARBON, FILMS, OXIDATION, THERMAL ANALYSIS, CHEMICAL BONDS, INFRARED SPECTRA, MOLECULAR STRUCTURE, HEAT TREATMENT

  11. Calidad de atención percibida y calidad de vida relacionada con la salud en pacientes participantes de estudios clínicos de la ips idearg sas.

    OpenAIRE

    González Gamboa, Carolina Stella

    2015-01-01

    La presente investigación surge en el programa de Bienestar y Calidad de Vida suscrito a la Línea de Liderazgo en la Escuela de Administración de la Universidad del Rosario, con el objetivo de describir si las subdimensiones de la calidad de la atención percibida guardan relación con la calidad de vida relacionada con la salud en los pacientes participantes en Estudios Clínicos en la Institución Prestadora de Servicios de Salud IDEARG SAS, considerando si los factores sociodemográficos se con...

  12. Evaluación de la gestión de residuos derivados del proceso de impresión en Datapoint de Colombia S.A.S, y propuesta de mejora

    OpenAIRE

    Fino Gallego, Sandra Patricia; Gómez Gianine, Carol Ruchina; Ruano Reyes, Sandra Milena

    2015-01-01

    Este trabajo se centra en el análisis de las actividades desarrolladas en torno a los servicios de procesos de impresión que ofrece la organización DATAPOINT de Colombia SAS para identificar los puntos críticos en la gestión de los residuos de impresión y las decisiones tomadas por parte de los involucrados durante todo el proceso (proveedores, clientes y la empresa), con el fin de revisar medidas y estrategias que permitan fortalecer la gestión integral de residuos de impresión a partir d...

  13. Diseño del sistema de gestión integrado de calidad NTC ISO 9001:2008 y medio ambiente NTC ISO 14001:2004 en Aerologistics S.A.S.

    OpenAIRE

    2012-01-01

    Con el fin de encontrar mejores oportunidades para la empresa Aerologistics S.A.S., se busca diseñar el Sistema de Gestión Integrado que proporcione mayor orden y mejor perspectiva por parte del cliente de lo que es el negocio y los servicios de la empresa. Se busca diseñar un Sistema de gestión con base en las normas NTC ISO 9001: 2008 y NTC ISO 14001: 2004 con el fin de mejorar la gestión de la calidad y ambiental de la actividad de la empresa.

  14. Diseño del plan integrado de gestión basado en las normas ISO 14001:2004 y OHSAS 18001:2007 en Ingeniería del Valle de Mares, Vallmar S.A.S

    OpenAIRE

    Vera Rodríguez, Aura Milena

    2013-01-01

    Evalúa la situación actual de los sistemas de riesgos laborales y medio ambiente en la empresa Vallmar S.A.S., por medio de matrices de riesgos e impactos ambientales. Acorde al resultado de dicho análisis se realiza el diseño del plan integral de gestión, tanto para el contexto administrativo como el operativo de la empresa bajo la norma ISO 14001:2004 y OHSAS 18001:2007. Esta investigación permitirá analizar el funcionamiento de la empresa, evaluando los diferentes procesos, y realizand...

  15. Plan de mejoramiento para el área de logística a nivel local de la compañía RotamAgrochemical Colombia S.A.S.

    OpenAIRE

    Gómez Susa, Martha Jannett; Morales Valero, Nadine Stella; Mosquera López, Diana Milena

    2013-01-01

    El trabajo pretende diseñar un plan de mejoramiento en el área logística que agregue valor, aumente la eficiencia y mejore los procesos de almacenamiento y distribución, gestión de inventarios y control de los productos agroquímicos de la Compañía RotamAgrochemical Colombia S.A.S., se formulan algunas recomendaciones para el mejoramiento de los procesos en las Áreas de almacenamiento, inventarios y seguridad industrial

  16. SAS、PASS、Stata三种常用软件样本量计算方法及结果差异的比较%Comparing the differences between SAS, PASS and Stata for sample size calculation

    Institute of Scientific and Technical Information of China (English)

    林洁; 孙志明

    2015-01-01

    Objective To analyze the differences between SAS, PASS and Stata for sample size calculation in a test of two means (rates) and recommend the appropriate software for sample size calculation. Methods By setting different pa-rameters, sample sizes were calculated using three kinds of software respectively and compared with the formula results. Results In two sample means test, Stata and PASS had the most accurate results, the results in SAS were affected by different parameters. In two sample rates test, the SAS results were the best of three, the accuracy of PASS was related with the sample size, the results in Stata were larger than others and affected by different parameters. Conclusion The results are not consistent using different software, SAS is recommended for two sample mean (rate) of sample size calcu-lation.%目的:分析和探讨运用SAS、PASS、Stata 3种软件在两均数(率)比较中进行样本量估计的结果差异,推荐合适的样本量估计软件。方法通过设定不同的参数情况,分别运用3种软件计算各自样本量,并且与公式计算结果进行比较。结果在两均数比较时,Stata和PASS的样本量估计结果最准确,不同的参数会影响SAS的结果;在两个率比较时,SAS最准确,PASS的准确性与样本量大小有关系,Stata结果偏大且受不同参数的影响。结论不同软件计算结果并不一致,综合考虑推荐用SAS软件进行两样本均数(率)比较的样本量估计。

  17. Research of Linear Programming Problem on SAS/or and LINGO Mathematics Softwear%应用SAS/OR与LINGO求解优化问题的比较研究

    Institute of Scientific and Technical Information of China (English)

    滕飞

    2011-01-01

    本文对一给定的线性规划问题,分别利用统计分析软件SAS的0R模块和LINGO优化软件进行求解和分析,并对这两种数学软件在求解规划问题上的差异上的比较,得出了LINGO优化软件比较适合求解线性规划问题的结论.%In this paper, the writer adopts the statistical analysis software SAS/OR module and the LINGO optimization software to solve linear programming problems, and compares the differences.

  18. Scafom International BV v. Lorraine Tubes S.A.S.: a case review of changing circumstances under the United Nations Convention on International Sale of Goods (CISG of 1980

    Directory of Open Access Journals (Sweden)

    Amalina AHMAD TAJUDIN

    2014-12-01

    Full Text Available This paper analyses the Belgium Supreme Court decision of Scafom International BV v. Lorraine Tubes S.A.S. The case involved a contract of sale of volatile goods ie steel tubes whereby a fixed-price contract caused it to be unenforceable because of the 70% market price increase just before the goods were delivered to the buyer. While the seller requested for renegotiation, for a higher contract price, the buyer refused to come to terms with the former. The court, by virtue of the United Nations sales law, held that renegotiation was the appropriate remedy in such a situation. In addition, the paper tests the different possible outcomes of this decision under the English Sale of Goods Act 1979, as well as the US Uniform Commercial Code. The finding of this test proves that these two sales laws would have tackled the issue of volatile market differently from that of the United Nations’.

  19. 框架的五种重要运算方法及其SAS源代码%Five Important Operation Methods and the SAS Codes of These Methods for Frame

    Institute of Scientific and Technical Information of China (English)

    王萌; 罗纯; 纪忠杰; 张应山

    2012-01-01

    多边矩阵的定义主要基于框架,设计框架是应用多边矩阵理论最基础的部分。为了方便设计出各种复杂框架,现拓展了矩阵理论的相关运算方法,归纳了框架的五种重要运算方法,并提供了这些运算方法的SAS源代码。%The definition of the multilateral matrix is mainly based on the frames. So designing the frames is the basic part of applying multilateral matrix theory. To design complex frames conveniently, the correlative operation methods in the matrix theory are expanded and five important operation methods for frame are generalized. Finally, for other scholars to apply the methods conveniently, the SAS codes of these methods are provided.

  20. Reflexões sobre as transformações contemporâneas no trabalho do Assistente Social: estudo sobre a Superintendência de Assistência Social da Universidade de São Paulo SAS-USP

    OpenAIRE

    Negrão, Adriana Ribeiro

    2015-01-01

    Este estudo teve como objetivos problematizar e aprofundar a reflexão sobre os fenômenos contemporâneos da intensificação, precarização e informatização dos processos de trabalho no cotidiano das assistentes sociais da SAS-USP. O primeiro capítulo retrata a trajetória histórica da Universidade de São Paulo e da Superintendência de Assistência Social, bem como traz à cena do debate a assistência estudantil na perspectiva da viabilização do direito ao ensino superior público e...

  1. Application of SAS macro to evaluated multiplicative and additive interaction in logistic and Cox regression in clinical practices%实现logistic与Cox回归相乘相加交互作用的临床实践宏程序

    Institute of Scientific and Technical Information of China (English)

    聂志强; 欧艳秋; 庄建; 曲艳吉; 麦劲壮; 陈寄梅; 刘小清

    2016-01-01

    病例对照研究常采用条件或非条件logistic分析,生存资料分析常采用Cox比例模型,但多数文献仅纳入主效应模型,然而广义线性模型不同于一般线性模型,其交互作用分为相乘交互与相加交互作用,前者只有统计学意义而后者更符合生物学意义.笔者以SAS 9.4软件编写宏,在计算logistic与Cox相乘交互项同时计算交互对比度、归因比、交互作用指数指标及利用Wald、Delta、PL(profile likelihood)3种方法的可信区间评价相加交互作用,便于临床流行病学与遗传学大数据分析相乘相加交互作用时参考.%Conditional logistic regression analysis and unconditional logistic regression analysis are commonly used in case control study,but Cox proportional hazard model is often used in survival data analysis.Most literature only refer to main effect model,however,generalized linear model differs from general linear model,and the interaction was composed of multiplicative interaction and additive interaction.The former is only statistical significant,but the latter has biological significance.In this paper,macros was written by using SAS 9.4 and the contrast ratio,attributable proportion due to interaction and synergy index were calculated while calculating the items of logistic and Cox regression interactions,and the confidence intervals of Wald,delta and profile likelihood were used to evaluate additive interaction for the reference in big data analysis in clinical epidemiology and in analysis of genetic multiplicative and additive interactions.

  2. 计量资料非劣效临床试验样本量及把握度的计算与SAS程序实现%SAS programming for sample size and power calculation of measurement data in non-inferior trials

    Institute of Scientific and Technical Information of China (English)

    文世梅; 陈云飞; 刘华

    2013-01-01

    AIM: To calculate sample size and power of measurement data in non-inferior trials using SAS programming. METHODS;Two cal culation method, formula and SAS program ming, were compared based on examples and the SAS macro for power was given as well. RE SULTS: The calculation results of SAS program ming was consistent with the formula, and SAS programming can directly give the result was more convenient without looking-up table to ob tain the relevant parameters. CONCLUSION: It is helpful for investigator to have a better under standing at this programming to calculate sample size and power provided in this paper.%目的:利用SAS简易快速对计量资料非劣效临床试验进行样本量及把握度的计算.方法:比较公式及SAS编程两种计算方法,同时给出反推把握度的SAS宏程序.结果:公式和SAS程序两种计算方法的结果一致,利用SAS程序可以直接给出结果,无需要再进行查表获得相关参数,更简单、快捷.结论:利用本文提供的程序可以更好地帮助研究者理解与运用此程序进行样本量和把握度的估算,为此类新药临床试验服务.

  3. Statistical analysis of medical data using SAS

    CERN Document Server

    Der, Geoff

    2005-01-01

    An Introduction to SASDescribing and Summarizing DataBasic InferenceScatterplots Correlation: Simple Regression and SmoothingAnalysis of Variance and CovarianceMultiple RegressionLogistic RegressionThe Generalized Linear ModelGeneralized Additive ModelsNonlinear Regression ModelsThe Analysis of Longitudinal Data IThe Analysis of Longitudinal Data II: Models for Normal Response VariablesThe Analysis of Longitudinal Data III: Non-Normal ResponseSurvival AnalysisAnalysis Multivariate Date: Principal Components and Cluster AnalysisReferences

  4. SAS 3 observations of GX 1 + 4

    Science.gov (United States)

    Doty, J. P.; Lewin, W. H. G.; Hoffman, J. A.

    1981-01-01

    GX 1 + 4 is one of the brightest celestial sources of high-energy X-rays. It is a pulsar with a period of approximately 2 min (perhaps a multiple of 2 min), decreasing at a variable rate which, since 1971, has averaged approximately 2% per year, but which can be larger than 5% per year. This is the largest rate of decrease observed for any pulsar. The rate of decrease appears to be correlated with the luminosity, in support of the idea that the period decrease is produced by accretion torques acting upon a neutron star. No evidence is seen for a Doppler shift due to motion of the pulsar in a binary orbit; this is consistent with the results of optical observations which suggest that any orbital period is fairly long (months to years). The spectrum of GX 1 + 4 is measured as a function of pulse phase, as well as the phase-averaged total spectrum, and the average spectrum of the pulses alone. The shape of the average pulsed spectrum suggests that the pulsations may be produced by 'hot spots' which are a few hundred meters in extent, with temperatures of approximately 10 to the 8th K (kT being approximately equal to 8 keV).

  5. 基于SAS的全球外来医学媒介生物截获统计地图绘制%Drawing of a global statistical map of captured exotic medical vectors based on SAS system

    Institute of Scientific and Technical Information of China (English)

    裘炯良; 郑剑宁; 林军; 马立新

    2012-01-01

    目的 探索基于SAS的统计地图绘制方法,及其在出入境检验检疫系统卫生检疫外来媒介生物监测工作中的应用.方法 应用统计地图法并采用国际权威的统计分析标准软件SAS分析平台进行编程,实现外来媒介生物截获信息的分类统计、数据分析,以及在世界地图上的实时、动态、全自动标注.结果 计算机自动绘制世界地图,根据20个国家首都的经纬度数据在图中用星号(★)标注出相应的国家位置,并用蓝、黄、橙、红4种颜色分别代表截获的媒介生物数量等级.来自巴拿马、巴西、泰国等国家的外来媒介生物量均以蓝星标注,表明截获量相对较少;来自韩国、南非等国家的外来媒介生物量均以红星标注,提示来自这些国家的外来医学媒介生物截获量相对较多.结论 统计地图可以直观、简便、动态地呈现外来媒介生物截获量在不同国家的分布情况,有助于检验检疫部门及时、准确、合理地分配力量,重点加强媒介截获量较大的来源国卫生检疫监管工作.%Objective To explore the drawing method of a statistical map based on statistics analysis system (SAS) and its application in the surveillance of exotic medical vectors and risk analysis in entry - exit inspection and quarantine system. Methods The statistical map method based on SAS program was applied for the classification statistics and data analysis of exotic medical vectors, with real-time, dynamic and automatic marking on the world map actualized. Results A world map was automatically drawn by computer and the related data and messages were labelled real-timely, dynamically and automatically on the world map in different colours. The locations of the twenty countries covered in this study were marked as asterisk in the map based on the longitude and latitude degree values of the capitals in those countries. Blue, yellow, orange and red colours were used to represent the

  6. 高敏C反应蛋白水平与2型糖尿病患者亚临床动脉粥样硬化关系研究%Research on correlation between Hs-CRP levels and T2D patients' SAS

    Institute of Scientific and Technical Information of China (English)

    张邻川

    2012-01-01

    Objective To discuss the correlation between hs-CRP levels and T2D patients'atheroma.Methods 140 T2D patients were visited for follow-up,tested and divided into groups and the hs-CRP levels were compared as T2D patients with and without SAS and the healthy control group.Results The depths of CCA-TMT and FA-TMT and hs-CRP levels of T2DM with and without SAS were both higher than those of the control group(P < 0.05).The depths of CCA-TMT and FA-TMT and hs-CRP levels of T2DM with SAS were all higher than those of the T2DM without SAS(P < 0.05).Conclusion T2DM patients with SAS all go through sub-clinical inflammation condition of different degrees.Constant and chronic increase of hs-CRP levels is an independent risk factor for SAS occurrence.%目的 探讨高敏C反应蛋白水平与2型糖尿病患者亚临床动脉粥样硬化的关系.方法 通过对140例T2DM患者进行随访、检测、分组,比较T2DM患者伴SAS、不伴SAS与健康对照组的hs-CRP水平.结果 T2DM伴SAS组与无SAS组CCA-IMT、FA-IMT厚度及hs-CRP水平均明显高于对照组(P< 0.05); T2DM伴SAS组CCA-IMT、FA-IMT厚度及hs-CRP水平均高于无SAS组(P<0.05).结论 T2DM及伴有SAS患者和均有不同程度的亚临床炎症状态,持续、慢性的hs-CRP升高是T2DM患者发生SAS的独立危险因素.

  7. Anastrozole versus tamoxifen as adjuvant therapy for Japanese postmenopausal patients with hormone-responsive breast cancer: efficacy results of long-term follow-up data from the N-SAS BC 03 trial.

    Science.gov (United States)

    Aihara, Tomohiko; Yokota, Isao; Hozumi, Yasuo; Aogi, Kenjiro; Iwata, Hiroji; Tamura, Motoshi; Fukuuchi, Atsushi; Makino, Haruhiko; Kim, Ryungsa; Andoh, Masashi; Tsugawa, Koichiro; Ohno, Shinji; Yamaguchi, Takuhiro; Ohashi, Yasuo; Watanabe, Toru; Takatsuka, Yuichi; Mukai, Hirofumi

    2014-11-01

    Aromatase inhibitors are superior to tamoxifen as adjuvant therapy in postmenopausal patients with hormone-responsive breast cancer. We report the follow-up efficacy results from the N-SAS BC 03 trial (UMIN CTRID: C000000056) where anastrozole was compared with tamoxifen as adjuvant therapy in postmenopausal Japanese patients with hormone-responsive early breast cancer. The full analysis set contained 696 patients (anastrozole arm, n = 345; tamoxifen arm, n = 351). The log-rank test was used to compare the two groups in terms of disease-free survival (DFS) and relapse-free survival (RFS); Kaplan-Meier estimates were calculated. The treatment effects were estimated by Cox's proportional hazards model. To examine time-varying effect of hazard ratios, we estimated time-varying hazard ratios at time t [HR(t)] using data from time t up to 12 months. After a median follow-up of 98.5 months, hazard ratios (95% CIs) were 0.90 (0.65-1.24; log-rank p = 0.526) for DFS and 0.83 (0.56-1.23; log-rank p = 0.344) for RFS. Hazard ratios (95% CIs) for DFS and RFS up to 36 months were 0.69 (0.40-1.17) and 0.54 (0.27-1.06) and those after 36 months were 1.06 (0.70-1.59) and 1.05 (0.64-1.73), respectively. Time-varying hazard ratios for both DFS and RFS showed that hazard ratios were initially in favor of anastrozole and approached 1.0 at around 36 months. Superior efficacy of anastrozole to tamoxifen suggested by the initial analysis was not confirmed in the present analysis after a long-term follow-up period. Advantage of anastrozole was the greatest immediately after switching from tamoxifen and then decreased thereafter.

  8. PAI- 1 4G/5G Polymorphism in patients with SAS%睡眠呼吸暂停综合征患者PAI-1 4G/5G基因多态性分析

    Institute of Scientific and Technical Information of China (English)

    徐霞; 王言森; 高辉

    2001-01-01

    目的研究睡眠呼吸暂停综合症(SAS)患者纤溶酶原激活物抑制物-1(PAI-1)活性(PAI-1:A)及含量(PAI-1:Ag)与PAI-1 4G/5G基因多态性的关系.方法依据睡眠呼吸监测的结果,将实验对象分为2组,正常对照组与SAS组,分别测定其血浆PAI-1:A和PA1-1:Ag、PA1-1 4G/5G基因多态性(RFLP),并用SPSS软件包进行统计学分析.结果SAS患者4G/4G+4G/5G基因型出现频率显著高于对照组.4G/4G基因型PA1-1:A和PAI-1:Ag的水平最高,其次为4G/5G基因型,5G/5G基因型PAI-1:A和PAI-1:Ag的水平最低,经统计学检验差异显著.结论 PAI-1的基因型与PA1-1:A及PAI-1:Ag水平之间关系密切.SAS患者具有较高的4G/4G、4G/5G基因频率,血浆PAI-1:A及PAI-1:Ag水平亦较高,所以我们认为SAS患者罹患心血管疾病的危险性更高,但SAS与心血管疾病的相互关系尚待进一步研究.

  9. 75 FR 78596 - Airworthiness Directives; Hawker Beechcraft Corporation Models B200, B200GT, B300, and B300C...

    Science.gov (United States)

    2010-12-16

    ... in any category: Table 1--Affected Airplane Models and Serial Numbers Model Serial numbers B200 BB... Transport Association (ATA) of America Code 30, Ice and Rain Protection. Unsafe Condition (e) This AD was...

  10. Performance Evaluation of Mineral Additive-free Perfluoropolymer Nanocomposite O-ring in Simulated Geothermal Environments of 300C

    Energy Technology Data Exchange (ETDEWEB)

    Sugama, Toshifumi [Brookhaven National Lab. (BNL), Upton, NY (United States); Pyatina, Tatiana [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-12-31

    The objective of this research was to evaluate the performance of O-rings made with a mineral additive-free perfluoropolymer (FFKM) nanocomposite in mitigating irremovable silica- and silicate-scaling, inhibiting oxidative reactions, minimizing the changes in mechanical behaviors, and maintaining the integrity of O-rings after their exposure to the five different simulated geothermal environments at 300°C: 1) 0.01N sodium metasilicate (SMS)-laden non-aerated (NR2R R(g) Rsaturated) steam-cooling cycles; 2) 0.01N SMS-laden aerated steam-cooling cycles; 3) water-based drilling fluid; 4) COR2R-rich geo-brine fluid; and, 5) heat-cool water quenching cycles (thermal shock). All the thermochemical environments 1 to 4 were carried out under a pressure of 8.3 MPs.

  11. The Prospects of SAS Interferometry for Detection and Classification (SAS Interferometrie voor Detectie en Classificatie)

    Science.gov (United States)

    2008-10-01

    2001. [ 16] Chen, C. W., and Zebker, H.A., "Phase unwrapping for large SAR Interferograms: Statistical segmentation and generalized network models...Defensie en Veiligheid, Directie Directeur Markt , G.D. Klein Baltink 1 ex. TNO Defensie en Veiligheid, vestiging Den Haag, Manager

  12. 药物Ⅰ期临床试验计量资料统计分析自动报表的SAS实现%Statistical analysis process by SAS software to realize automatically statements of measurement data in phase Ⅰ clinical trials

    Institute of Scientific and Technical Information of China (English)

    段锋; 魏振满; 陈大为; 朱珍真; 屠舒; 毕京峰; 李文淑; 孙斌

    2013-01-01

    Objective To realize automatically statements of measurement data in phase I clinical trials by SAS software. Methods Based on the SAS software, we used its functions, such as spliting table, statistical analysis, choosing results, transposing table, mergering tables horizontally or lengthways, to built statements of measurement data step by step. Results The statistical analysis results were imported to EXELE form automaticlly as report requirement. Conclusion The process is accurate and reliable, and saves time and effort. It is suitable for the non-professional statistical researchers to realize automatically statements of measurement data.%目的 借助SAS软件实现Ⅰ期临床试验计量资料统计分析的自动报表.方法 基于SAS软件,应用其拆分表格、统计分析、结果选择、表格转置、横向合并表格、纵向合并表格等程序逐步导出报表.结果 借助EXELE表格成功实现药物Ⅰ期临床试验计量资料统计分析结果的自动报表.结论 该过程省时省力,准确可靠,为非统计专业医学研究人员提供了一种简便、可靠的自动报表方法.

  13. The Use Of Electromagnetic And Electrical Resistivity Methods In Assessing Groundwater Resource Potentials In Adoe Sunyani Ghana.

    Directory of Open Access Journals (Sweden)

    Alfred K. Bienibuor

    2015-08-01

    Full Text Available Electromagnetic and electrical resistivity geophysical methods were used to map out potential groundwater sites for boreholes drilling in the Adoe community in the Sunyani west district of Ghana. The electromagnetic data was taken with the Geonics EM-34 conductivity meter while the electrical resistivity data was taken with the ABEM SAS 1000 C Terrameter using the Schlumberger electrode configuration. Results from the measurements revealed four subsurface geological layers of the following resistivity and thickness ranges quartzitic sandstone with clay 42-118 amp937m 1-2.2 m sandy clay with silt 27-487 amp937m 9-12 m lateritic sandstone 13-728 amp937m 6-14 m and clayey shale 20-29 amp937m 6-14 m The overburden ranged in thickness from 14 m to 24 m. Sites selected for borehole drilling had a groundwater yield range of 0.94 -12 m3h.

  14. 基于SAS的出入境交通工具食源性疾病暴发流行快速溯源调查研究%Tracing survey based on SAS on food-borne disease outbreaks on entry-exit transport

    Institute of Scientific and Technical Information of China (English)

    裘炯良; 郑剑宁; 施惠祥; 张锜

    2012-01-01

    Objective To explore the tracing survey of food-bome disease outbreaks on entry-exit conveyances. Methods Four kind of chi square tests were employed for the analysis of food-bome disease outbreaks on the passenger liner after using relative epidemical survey tables. All of the procedures were executed by computer based on SAS program. Results The latent period was 28.94 h and exposure date was estimated as 9:33 on Sep. 5, 2009. Fresh milk was recognized as contaminated food, the value of OR was 9.03(93% CI = 2.2-33.63). Conclusion The tracing survey of food-borne disease outbreaks and relative SAS programs can provide a convenient, quick and effective tool for the prevention and control of food-bome diseases.%[目的]建立基于数据统计分析系统(SAS)的出入境交通工具食源性疾病暴发流行快速溯源调查方法.[方法]应用4种x2检验法,结合食源性疾病暴发流行调查样表,分析某口岸国际大型豪华邮轮上暴发的食源性疾病.并采用国际权威的统计分析标准软件SAS分析平台进行编程实现.[结果]经流行病学快速溯源调查,潜伏期为28.94h,暴露日期估计为2009年9月5日9时33分,鲜奶作为污染食品列为高风险因素,其OR值为9.03 (95% Cl=2.2~33.63).[结论]食源性疾病暴发流行快速溯源调查方法及SAS程序为口岸食源性疾病的防控提供了一种简便、快捷且客观有效的工具.

  15. El Administrador de Hecho -SAS- frente al Director Oculto

    Directory of Open Access Journals (Sweden)

    María Mónica Pino Sonalo

    2010-06-01

    Full Text Available Con el fin de generar una postura crítica en torno a la consagración del administrador de hecho en la ley 1258 de 2008 como figura novedosa del Ordenamiento Jurídico colombiano, los autores en esta ocasión han hecho un recorrido sobre la noción del administrador de hecho y del administrador oculto alrededor del Derecho Comparado, para determinar su aplicación y consecuencias jurídicas en nuestro ordenamiento jurídico, como unas figuras tendientes a la extensión de la responsabilidad de los administradores de sociedades.

  16. Provider Specific Data for Public Use in SAS Format

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Fiscal Intermediary maintains the Provider Specific File (PSF). The file contains information about the facts specific to the provider that affects computations...

  17. PROC LCA: A SAS Procedure for Latent Class Analysis

    Science.gov (United States)

    Lanza, Stephanie T.; Collins, Linda M.; Lemmon, David R.; Schafer, Joseph L.

    2007-01-01

    Latent class analysis (LCA) is a statistical method used to identify a set of discrete, mutually exclusive latent classes of individuals based on their responses to a set of observed categorical variables. In multiple-group LCA, both the measurement part and structural part of the model can vary across groups, and measurement invariance across…

  18. PROC LCA: A SAS Procedure for Latent Class Analysis

    Science.gov (United States)

    Lanza, Stephanie T.; Collins, Linda M.; Lemmon, David R.; Schafer, Joseph L.

    2007-01-01

    Latent class analysis (LCA) is a statistical method used to identify a set of discrete, mutually exclusive latent classes of individuals based on their responses to a set of observed categorical variables. In multiple-group LCA, both the measurement part and structural part of the model can vary across groups, and measurement invariance across…

  19. SAS Launches Biometric Identification at Airports All Over Sweden

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Scandinavian Airlines is to launch a new biometric identification system throughout Sweden.When traveling, your fingerprint will be matched to your check-in baggage. This makes the check-in process easier and improves security. The new technology will be launched during November and December at almost all airports served by Scandinavian Airlines in Sweden.

  20. A handbook of statistical graphics using SAS ODS

    CERN Document Server

    Der, Geoff

    2014-01-01

    An Introduction to Graphics: Good Graphics, Bad Graphics, Catastrophic Graphics and Statistical GraphicsThe Challenger DisasterGraphical DisplaysA Little History and Some Early Graphical DisplaysGraphical DeceptionAn Introduction to ODS GraphicsGenerating ODS GraphsODS DestinationsStatistical Graphics ProceduresODS Graphs from Statistical ProceduresControlling ODS GraphicsControlling Labelling in GraphsODS Graphics EditorGraphs for Displaying the Characteristics of Univariate Data: Horse Racing, Mortality Rates, Forearm Lengths, Survival Times and Geyser EruptionsIntroductionPie Chart, Bar Cha

  1. Marginal maximum likelihood estimation in polytomous Rasch models using SAS

    DEFF Research Database (Denmark)

    Christensen, Karl Bang; Olsbjerg, Maja

    2013-01-01

    Dansk radiohistorie er på mange måder et uskrevet kapitel. Selvom der findes flere udgivelser fra Statsradiofonien selv og en dansk mediehistorie i fire bind, henligger mange centrale problemstillinger endnu i historiens mørke. Det vil nærværende afhandling søge at råde bod på med et fokus på tid...

  2. Nueva evidencia sobre la Statistical Anxiety Scale (SAS

    Directory of Open Access Journals (Sweden)

    Amparo Oliver

    2014-01-01

    Full Text Available Las asignaturas relacionadas con la estadística suelen tener problemas de rendimiento académico. La ansiedad se relaciona de forma negativa con el rendimiento y en particular, la ansiedad estadística puede ser un constructo clave en la mejora de la enseñanza de esta materia y afines. La Statistical Anxiety Scale (Vigil-Colet, Lorenzo-Seva y Condon, 2008 se creó con la pretensión de ser útil para predecir el rendimiento académico en estadística. Se fundamenta en tres dimensiones de ansiedad referidas a tres aspectos específicos: respecto al examen, cuando se pide ayuda en la comprensión de estadística y en el proceso de interpretación de resultados. Esta estructura de tres factores fue hallada en un primer momento por los autores de la escala y en una primera validación corroborada en estudiantes italianos y españoles. El presente estudio pretende añadir nueva evidencia sobre la fiabilidad y validez de la escala, empleando en el estudio de fiabilidad técnicas estadísticas robustas, y ampliando el estudio de la validez respecto a su principal criterio, el rendimiento académico, ya que no puede ser considerado sinónimo de autoeficacia.

  3. Plan de negocio para Tamarindo Seco S.A.S

    OpenAIRE

    Salazar Briceño, Julián Danilo; Vargas Gallego, Daniel Felipe; Lotta Gamba, Sebastián Rodrigo

    2017-01-01

    El planteamiento inicial del plan de negocios para Tamarindo Seco tiene como objetivo encontrar oportunidades de negocio con los productos actuales para involucrase y aportar al sector de consumo masivo en lo que se refiere a la alimentación saludable, con el único fin de cumplir un propósito superior, promover una cultura medio ambiental sostenible a través de la modificación en el manejo que se le da a los desperdicios que genera el consumo masivo de alimentos en Colombia y la región. Tenie...

  4. Spa Rituales Ancestrales AüA S.A.S.

    OpenAIRE

    Lozano Socarrás, Rosa Marina

    2013-01-01

    Las practicas ancestrales de las culturas precolombinas cada día son mas validas en su aplicación actual para la medicina alternativa, orientada al bienestar y la salud, es un hecho que en los últimos años se observa un gran crecimiento de endemias de estrés que se presentan bajo determinadas circunstancias propias del sistema actual de vida urbana y actividades cotidianas, ocasionando recargas de tensión como respuesta a la supervivencia en un mundo agitado. La somatizacion del estrés se tra...

  5. Symposium on atomic spectroscopy (SAS-83): abstracts and program

    Energy Technology Data Exchange (ETDEWEB)

    1983-09-01

    Abstracts of papers given at the symposium are presented. Session topics include: Rydbergs, optical radiators, and planetary atoms; highly ionized atoms; ultraviolet radiation; theory, ion traps, and laser cooling; beam foil; and astronomy. (GHT)

  6. Strategic Directions in Software at Scale (SaS)

    Science.gov (United States)

    2010-11-01

    Goodenough , Fellow, Carnegie Mellon University Software Engineering Institute Engineering Processes that Engineer Scalable Systems Lee Osterweil...Minimal investment required: mainly theoretical investigation, a few good minds. Best Case Significant brain power. Plus test tools...computing hours, and lab space. Middle Case Major research infrastructure: specialized hardware and software, specialized test ware Worst Case

  7. SAS procedures for designing and analyzing sample surveys

    Science.gov (United States)

    Stafford, Joshua D.; Reinecke, Kenneth J.; Kaminski, Richard M.

    2003-01-01

    Complex surveys often are necessary to estimate occurrence (or distribution), density, and abundance of plants and animals for purposes of re-search and conservation. Most scientists are familiar with simple random sampling, where sample units are selected from a population of interest (sampling frame) with equal probability. However, the goal of ecological surveys often is to make inferences about populations over large or complex spatial areas where organisms are not homogeneously distributed or sampling frames are in-convenient or impossible to construct. Candidate sampling strategies for such complex surveys include stratified,multistage, and adaptive sampling (Thompson 1992, Buckland 1994).

  8. SAS 3 observations of Cygnus X-1 - The intensity dips

    Science.gov (United States)

    Remillard, R. A.; Canizares, C. R.

    1984-01-01

    In general, the dips are observed to occur near superior conjunctions of the X-ray source, but one pair of 2-minute dips occurs when the X-ray source is closer to the observer than is the supergiant companion. The dips are analyzed spectrally with the aid of seven energy channels in the range 1.2-50 keV. Essentially, there is no change in the spectral index during the dips. Reductions in the count rates are observed at energies exceeding 6 keV for some of the dips, but the dip amplitude is always significantly greater in the 1.2-3 keV band. It is believed that absorption by partially ionized gas may best explain these results, since the observations of Pravdo et al. (1980) rule out absorption by unionized material. Estimates for the intervening gas density, extent, and distance from the X-ray source are presented. Attention is also given to the problems confronting the models for the injection of gas through the line of sight, believed to be inclined by approximately 30 deg from the binary pole.

  9. SAS 3 and related observations of Abell 2029

    Science.gov (United States)

    Johnson, H. M.; Schnopper, H. W.; Delvaille, J. P.

    1980-01-01

    X-ray and radio observations of the cluster of galaxies show that the central cD galaxy dominates the emissions. Resolution of the X-ray source shows that its extent is significantly greater than that of the profile of surface brightness of the cD galaxy. Dressler's model of most of the cluster mass with very high M/L(v) is similarly extended. The optically dark mass may provide low-energy X-ray emission of the coronae of 5 x 10 to the 16th stars with very high M/L(v), but in the 2-10 keV range the data are consistent with current theoretical predictions for hot intracluster gas.

  10. GENERATING PARTICIPANT SPECIFIC FIGURES USING SAS GRAPHIC PROCEDURES

    Science.gov (United States)

    An important part of our research at the U.S. Environmental Protection Agency (EPA) is to effectively communicate the results from observational studies to the study participants. This can be particularly challenging where participants are from different socio-economic background...

  11. Electrochemistry in Near-Critical and Supercritical Fluids. 6. The Electrochemistry of Ferrocene and Phenazine in Acetonitrile between 25C and 300C.

    Science.gov (United States)

    1987-07-01

    Prepared for Publication SD in Journal of Electroanalytical Chemistry The University of Texas at Austin Department of Chemistry Austin, Texas 78712...IS S,.PPLEMEINTARY NCTES Prepared for publication in the Journal of Electroanalytical Chemistry IS. K LY WORDS (Continue on reverse side if neceeesar...Journal of Electroanalytical Chemistry July 1987 2 I NTRODUCTI ON Previous reports from this laboratory have demonstrated that inorganic supercritical

  12. 300C/15 kW power converter with AlGaN/GaN-Si MOS-HFETs for electric propulsion systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Capitalizing on a strong expertise in III-Nitride epitaxy, GaN-Si power device designs, and wide-bandgap power electronics, researchers at GeneSiC Semiconductor...

  13. Delineating The Subsurface Structures Using Electrical Resistivity Sounding In Some Part Of Willeton Perth Western Australia

    Directory of Open Access Journals (Sweden)

    Okan Evans Onojasun

    2015-08-01

    Full Text Available Abstract Geophysical survey using electrical resistivity methods has been carried out within the industrial area of Willeton Perth Western Australia with the view to delineate the geoelectric characteristics of the basement complex and evaluate the groundwater potential in the area. Vertical electrical sounding with ABEM SAS 3000 Terrameter and Schlumberger electrode configuration were employed for data acquisition. Apparent resistivity values obtained from the field measurements were plotted against half current electrodes spacing on a log-log graph while a model was suggested to fit the resistivity distribution presented in the sounding. The results from the modelling were finally iterated to the lowest Root Mean Square RMS percentage error using computer software A 7 point filter derived by Guptasarma to calculate a forward model. Analysis of the results showed that the study area has fairly homogenous subsurface stratification with four distinct subsurface layers above the depth of 37m. The four subsurface layers comprises top soil mainly of unconsolidated and sand containing organic matter unsaturated sand layer with consolidated and highly resistive water saturated sand layer with highly water saturated soil and the sub-stratum layer consisting of clay material. The aquifer performance is best at about 32m hence it is suggested that boreholes for sustainable water supply in this area should be drilled to about 32 m to hit prolific aquifer.

  14. Evaluation of sub-soil geo-electric properties in a proposed power sub-station site at Ebubu, Rivers State, Nigeria

    Directory of Open Access Journals (Sweden)

    T.K.S. Abam

    2014-09-01

    Full Text Available Electrical resistivity survey was carried out in a site proposed for the construction and installation of a Power sub-station. The project will involve subsurface installation of cables and other objects that easily conduct electricity. Extant laws including EIA also require knowledge of subsurface distribution of resistivity in construction projects that would involve burial of steel pipes and cables. The imperative of this is emphasized by the location of the project in an area of shallow groundwater conditions. Field resistivity measurements were undertaken using ABEM Terrameter SAS 1000, adopting Schlumberger configuration in vertical electric sounding at 12 locations within the study site. The results were used to generate geo-electric log models. Three geo-electric profile models (pseudo- profiles were also taken NE-SW of the site. Interpretation of the models shows that the area is characterized by two geo-electric layers to the depth of 30m. The upper layer of lower resistivity occurs to a depth of 2-3m. This layer consists of lateritic to silty sands. The lower layer has a resistivity of between 900 - >2000 Ωm and represents fine to coarse sands and gravels. On the Soil Electrical Resistivity Classification (BS 1377, the subsoil falls within non-corrosive class. Objects installed in the soil are not likely to suffer corrosion soon. Similarly, subsurface electrical installations will pose minimal hazards and would require basic precautions to avoid electrical accidents.

  15. Geological and geophysical investigation of water leakage from two micro-dam reservoirs: Implications for future site selection, northern Ethiopia

    Science.gov (United States)

    Berhane, Gebremedhin; Amare, Mogos; Gebreyohannes, Tesfamichael; Walraevens, Kristine

    2017-05-01

    Water resources are essential to human development activities and to eradicate extreme poverty and hunger. Geological problems of two water harvesting Micro-Dam Reservoirs (MDRs) were evaluated from leakage perspectives in the northern part of Ethiopia, East Africa. Conventional geological mapping, discontinuity and weathering descriptions, test pits and geophysical methods were used to characterize the hydrogeological features of the MDRs. Vertical Electrical Sounding (VES) and Electrical Profiling (EP), were executed using Terrameter SAS (signal averaging system) 1000 manufactured by ABEM, Sweden, with Schlumberger and Wenner array configuration respectively. It was concluded that the foundations of both MDRs, except the right abutment for Adishuhu which is partly composed of dolerite, are pervious due to the presence of thin bedding planes, joints, weathered materials and fault. The presence of water in the downstream toe of the MDRs, at depressions, existing test pits and test pits excavated during the present study which lie within the seepage zone demarcated during surface geological mapping, correspond with the electrical resistivity study. The results of the electrical resistivity survey (EP and VES) were merged with the geological and structural mapping and the observation of seepage zones, for the delineation of weak zones responsible for leakage. Monitoring of the leakage (reservoir water and groundwater levels), both manually and using automatic divers, is recommended, along with monitoring of the stability of the embankments and the discharge or flow downstream of the MDRs.

  16. Implications Of Soil Resistivity Measurements Using The Electrical Resistivity Method A Case Study Of A Maize Farm Under Different Soil Preparation Modes At KNUST Agricultural Research Station Kumasi

    Directory of Open Access Journals (Sweden)

    Jakalia

    2015-01-01

    Full Text Available Abstract Continuous vertical electrical sounding CVES technique was used to investigate the soil moisture content of a maize farm at the Kwame Nkrumah University of Science and Technology KNUST Agricultural Research Station ARS Kumasi Ghana. The soils of the maize farm were categorized into four different land preparation modes ploughed-harrowed ploughed hoed and no-till plot. Time-lapse measurements with CVES was carried out using the multi-electrode Wenner array to investigate soil moisture variation with the help of the ABEM Terrameter SAS 4000 resistivity meter. The results showed a heterogeneous distribution of soil moisture content both spatially and temporally. Most of the water available for plants uptake was within a depth of 0.20 0.40 m which coincided with the root zones of the maize crops. In addition the no-till plot was found to conserve more moisture during dry weather conditions than the rest of the plots. The research shows that CVES technique is applicable in monitoring shallow soil water content in the field and the results obtained could be used to optimize irrigation scheduling and to assess the potential for variable-rate irrigation.

  17. Integrated geological and multi-electrode resistivity surveys for groundwater investigation in Kampung Rahmat village and its vicinity, Jeli district, Kelantan, Malaysia

    Science.gov (United States)

    Nazaruddin, Dony Adriansyah; Amiruzan, Zafirah Sakinah; Hussin, Hamzah; Jafar, Mohamad Taufiq Mohd

    2017-03-01

    The integration of geological and multi-electrode resistivity surveys has been carried out in Kampung Rahmat village and its vicinity, in Jeli district, Kelantan, Malaysia as part of the groundwater resources exploration for rural water supply. A geological survey in the study area has shown that the area consists of some topographic units: mountainous area, hilly area, and low-lying to undulating area. The study area is lithologically composed of granitic rocks (megacrystic biotite granite porphyry) overlain by Quaternary alluvial deposits (with weathered granite). For the multi-electrode resistivity survey, the Schlumberger array with a maximum electrode spread of 200 m was conducted by employing three resistivity survey lines, where data were collected by using the ABEM Terrameter SAS 4000 and ABEM LUND ES464 electrode selector system, and processed by using RES2DINV software. The images were presented in the form of two-dimensional (2D) resistivity profiles providing a clear view of the distribution of granitic rock basement and alluvial deposits (with the weathered granite) as well as potential groundwater zones. The results show that the study area has potential groundwater resources existing in the alluvium which become the unconfined aquifers. The combination between these two methods is reliable and successful in identifying potentially favorable zones for obtaining groundwater in the study area.

  18. IOT Test System——Anite SAS Based on Agilent 8960%基于Agilent 8960的IOT测试系统——Anite SAS

    Institute of Scientific and Technical Information of China (English)

    宋崇汶; 孙向前; 买望

    2009-01-01

    文章对基于Agilent 8960的IOT测试系统--SAS进行了全面的介绍.首先介绍了互操作性测试即IOT测试的必要性和基本内容,接着详细阐述了如何应用SAS系统实现IOT测试,最后对SAS系统的优点进行了分析.

  19. Weighted Poisson analyses à la Goodman using SAS-GENMOD. [Paper presented at 15th SAS European Users Group International SEUGI Conference, Madrid, 12-16 May 1997].

    NARCIS (Netherlands)

    Vogelesang, A.W.

    2010-01-01

    In traffic safety analysis, weight factors are often applied, to correct for road length, traffic volume, numbers of kilometers driven, etc. Also, many data are subdivided into classes (road type: freeway, 80 km/hr, two lanes, rural area, etc); combining factors often leads to a cross-classification

  20. An Extension of the Validation of SCALE (SAS2H) Isotopic Predictions for PWR Spent Fuel

    Energy Technology Data Exchange (ETDEWEB)

    DeHart, M.D.

    1993-01-01

    Isotopic characterization of spent fuel via depletion and decay calculations is necessary for determination of source terms for subsequent system analyses involving heat transfer, radiation shielding, isotopic migration, etc. Unlike fresh fuel assumptions typically employed in the criticality safety analysis of spent fuel configurations, burnup credit applications also rely on depletion and decay calculations to predict the isotopic composition of spent fuel. These isotopics are used in subsequent criticality calculations to assess the reduced worth of spent fuel. To validate the codes and data used in depletion approaches, experimental measurements are compared with numerical predictions for relevant spent fuel samples. Such comparisons have been performed in earlier work at the Oak Ridge National Laboratory (ORNL). This report describes additional independent measurements and corresponding calculations, which supplement the results of the earlier work. The current work includes measured isotopic data from 19 spent fuel samples obtained from the Italian Trino Vercelles pressurized-water reactor (PWR) and the U.S. Turkey Point Unit 3 PWR. In addition, an approach to determine biases and uncertainties between calculated and measured isotopic concentrations is discussed, together with a method to statistically combine these terms to obtain a conservative estimate of spent fuel isotopic concentrations. Results are presented based on the combination of measured-to-calculated ratios for earlier work and the current analyses. The results described herein represent an extension to a new reactor design not included in the earlier work, and spent fuel samples with enrichment as high as 3.9 wt % {sup 235}U. Results for the current work are found to be, for the most part, consistent with the findings of the earlier work. This consistency was observed for results obtained from each of two different cross-section libraries and suggests that the estimated biases determined for each of the isotopes in the earlier work are reasonably good estimates, as the additional measurement/calculated ratios resulting from the current work tend to confirm these estimates.

  1. A guide to generalized additive models in crop science using SAS and R

    Directory of Open Access Journals (Sweden)

    Josefine Liew

    2015-06-01

    Full Text Available Linear models and generalized linear models are well known and are used extensively in crop science. Generalized additive models (GAMs are less well known. GAMs extend generalized linear models through inclusion of smoothing functions of explanatory variables, e.g., spline functions, allowing the curves to bend to better describe the observed data. This article provides an introduction to GAMs in the context of crop science experiments. This is exemplified using a dataset consisting of four populations of perennial sow-thistle (Sonchus arvensis L., originating from two regions, for which emergence of shoots over time was compared.

  2. From Big Data to Meaningful Information with SAS High-Performance Analytics

    Directory of Open Access Journals (Sweden)

    Silvia BOLOHAN

    2013-10-01

    Full Text Available This paper is about the importance of Big Data and What You Can Accomplish with the data that counts. Until recently, organizations have been limited to using subsets of their data, or they were constrained to simplistic analyses because the sheer volumes of data overwhelmed their processing platforms. But, what is the point of collecting and storing terabytes of data if you can't analyze it in full context, or if you have to wait hours or days to get results? On the other hand, not all business questions are better answered by bigger data. How can you make the most of all that data, now and in the future? It is a twofold proposition. You can only optimize your success if you weave analytics into your solution. But you also need analytics to help you manage the data itself. There are several key technologies that can help you get a handle on your big data, and more importantly, extract meaningful value from it.

  3. Propuesta de diseño del Balanced Scorecard para AIP S.A.S.

    OpenAIRE

    Prieto Hernández, Jorge Iván; Estrada Salazar, Edwin Camilo; Cuadrado Salazar, Alex José

    2014-01-01

    Tesis (Maestria en Administración de Empresas ).--Universidad de La Salle. Facultad de Ciencas Administrativas y Contables. Maestria en Administración de Empresas, 2014 Bogotá : Universidad de la Salle. División de Formación Avanzada. Maestria en Administración

  4. A New SAS program for behavioral analysis of electrical penetration graph data

    Science.gov (United States)

    Monitoring feeding behaviors of insects whose piercing-sucking mouthparts are inserted into plant tissue is done by making the insect part of an electronic circuit, using electropenetrography (EPG). Fluctuating voltage signals in the circuit are graphed, and resulting waveforms are interpreted as sp...

  5. SAS ABM 助力浙江移动降低成本

    Institute of Scientific and Technical Information of China (English)

    乐宁

    2006-01-01

    今天,有效降低成本成为企业的必然选择。国际上在成本核算和成本控制上主要采用作业成本法(ABC),因此,基于作业成本法的作业成本管理(ABM)成为企业降低成本的全新手段。在应用ABM之前,企业都是采用传统的成本账务系统对成本进行管理。以电信企业为例,一直以来,我国大部份电信企业仍然用着传统的成本核算体系,致使产品的成本和盈利性无从得知,产品定价和决策没有得到有效支撑。这其中,浙江移动就是一个典型的例子,尽管浙江移动一直在努力进行业务创新,但面对激烈竞争的市场,他们一直面对提高企业利润的压力。

  6. Design and analysis of experiments classical and regression approaches with SAS

    CERN Document Server

    Onyiah, Leonard C

    2008-01-01

    Introductory Statistical Inference and Regression Analysis Elementary Statistical Inference Regression Analysis Experiments, the Completely Randomized Design (CRD)-Classical and Regression Approaches Experiments Experiments to Compare Treatments Some Basic Ideas Requirements of a Good Experiment One-Way Experimental Layout or the CRD: Design and Analysis Analysis of Experimental Data (Fixed Effects Model) Expected Values for the Sums of Squares The Analysis of Variance (ANOVA) Table Follow-Up Analysis to Check fo

  7. Actívate - Cuerpo y Mente S.A.S.

    OpenAIRE

    Posso Blandón, Luis Fernando; Isaza Silva, Paola Andrea

    2012-01-01

    El evidente aumento en la disposición del gasto promedio familiar hacia actividades de esparcimiento en Colombia y la carencia de una oferta integral y formal de servicios de entretenimiento en Santiago de Cali con una promesa de entrega en el lugar de domicilio de los clientes, dan origen al plan de empresa Actívate - Cuerpo y Mente (ACM), un proyecto que responde a esta necesidad, con una inversión inicial de $40.000.000 aportada por el grupo gestor y que busca contribuir a la calidad de vi...

  8. Caracterización de la Cultura Organizacional de Informatica Documental SAS

    OpenAIRE

    2014-01-01

    Actualmente, el estudio de la cultura organizacional se ha convertido en un tema de gran importancia para las empresas ya que, de acuerdo a que tan satisfecho este el empleado, esta tiene un impacto en el desempeño de la compañía, además se vuelve en un factor clave para el fracaso o el éxito de cada uno de los proyectos o tecnologías de gestión que implemente la organización. La cultura organizacional según el autor Carlos Eduardo Méndez Álvarez (2006) es: La conciencia colectiva q...

  9. Sasón y sabor en el suroriente colombiano: Amazonas y Orinoco

    OpenAIRE

    Prieto, Astrid Quintero

    2016-01-01

    RESUMENEsta investigación, presenta las costumbres y tradiciones culinarias y alimenticias de las regiones del Amazonas y el Orinoco en el suroriente colombiano, dos regiones hermanas unidas por territorio y geografía, que se complementan de manera perfecta para dar cabida a una de las cocinas más variadas y singulares del mundo. Pretende mostrar, así mismo, la cocina como patrimonio cultural inmaterial de los pueblos y como un arte, en el que cada plata, fruto, animal o semilla llevan impres...

  10. Proyecto de mejoramiento para la estacion de servicio "La Americana S.A.S"

    OpenAIRE

    Ortega Cepeda, Miguel Santiago; Ramírez Hernández, Javier Andrés

    2016-01-01

    La estación de servicio “La Americana S.A.S” ha sido una de las primeras estaciones de servicio ubicada en Bucaramanga, dedicada a la comercialización y distribución tanto de gasolina como de los diferentes repuestos y accesorios para los vehículos, razón por la cual desde su fundación y hasta nuestros días, ha venido prestando un servicio destacado, efectivo y cumpliendo siempre con la demanda del mercado proporcionalmente a su consumo. Del mismo modo dicha experiencia dentro de este sect...

  11. Integrative Biological Chemistry Program Includes The Use Of Informatics Tools, GIS And SAS Software Applications

    OpenAIRE

    D’Souza, Malcolm J.; Kashmar, Richard J.; Hurst, Kent; Fiedler, Frank; Gross, Catherine E.; Deol, Jasbir K.; Wilson, Alora

    2015-01-01

    Wesley College is a private, primarily undergraduate minority-serving institution located in the historic district of Dover, Delaware (DE). The College recently revised its baccalaureate biological chemistry program requirements to include a one-semester Physical Chemistry for the Life Sciences course and project-based experiential learning courses using instrumentation, data-collection, data-storage, statistical-modeling analysis, visualization, and computational techniques...

  12. An extension of the validation of SCALE (SAS2H) isotopic predictions for PWR spent fuel

    Energy Technology Data Exchange (ETDEWEB)

    DeHart, M.D.; Hermann, O.W.

    1996-09-01

    Isotopic characterization of spent fuel via depletion and decay calculations is necessary for determination of source terms. Unlike fresh fuel assumptions typically used in criticality safety analysis of spent fuel configurations, burnup credit applications also rely on depletion and decay calculations to predict spent fuel composition; these isotopics are used in subsequent criticality calculations to assess the reduced worth of spent fuel. To validate the depletion codes and data, experiment is compared with predictions; such comparisons have been done in earlier ORNL work. This report describes additional independent measurements and corresponding calculations as a supplement. The current work includes measured isotopic data from 19 spent fuel samples from the Italian Trino Vercelles PWR and the US Turkey Point-3 PWR. In addition, an approach to determine biases and uncertainties between calculated and measured isotopic concentrations is discussed, together with a method to statistically combine these terms to obtain a conservative estimate of spent fuel isotopic concentrations. Results on combination of measured-to-calculated ratios are presented. The results described herein represent an extension to a new reactor design and spent fuel samples with enrichment as high as 3.9 wt% {sup 235}U. Consistency with the earlier work for each of two different cross-section libraries suggests that the estimated biases for each of the isotopes in the earlier work are reasonably good estimates.

  13. Fitting Proportional Odds Models to Educational Data in Ordinal Logistic Regression Using Stata, SAS and SPSS

    Science.gov (United States)

    Liu, Xing

    2008-01-01

    The proportional odds (PO) model, which is also called cumulative odds model (Agresti, 1996, 2002 ; Armstrong & Sloan, 1989; Long, 1997, Long & Freese, 2006; McCullagh, 1980; McCullagh & Nelder, 1989; Powers & Xie, 2000; O'Connell, 2006), is one of the most commonly used models for the analysis of ordinal categorical data and comes from the class…

  14. Maximum Likelihood Estimation and Inference With Examples in R, SAS and ADMB

    CERN Document Server

    Millar, Russell B

    2011-01-01

    This book takes a fresh look at the popular and well-established method of maximum likelihood for statistical estimation and inference. It begins with an intuitive introduction to the concepts and background of likelihood, and moves through to the latest developments in maximum likelihood methodology, including general latent variable models and new material for the practical implementation of integrated likelihood using the free ADMB software. Fundamental issues of statistical inference are also examined, with a presentation of some of the philosophical debates underlying the choice of statis

  15. User’s Guide for the SAS (Stand-Off Attack Simulation) Computer Model.

    Science.gov (United States)

    1982-01-15

    69 7f, 71 7? so 81 * 1he firsr target qrouv corresponds to all weapon targets. * * , otice ttqt t~e final tarjet numbers are used when specifling the...NTrwiE Sroup ornzaciities fir all times of interest nave been foune (for :!?)FST -estroyed tarjets ). Write tne-p and find - ,irojo orotanillries for...corner of the fixed * tariet area rejAtive to tne oriitn in the target reference plane. If a * rando tarJet area 4as destred, vmljes for XTCTR and YTCTR

  16. SAS-2 High energy gamma-ray observations of the Vela pulsar

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Kniffen, D. A.; Oegelman, H. B.

    1975-01-01

    The second Small Astronomy Satellite high-energy (35 MeV) gamma-ray telescope detected pulsed gamma-ray emission at the radio period from PSR 0833-45, the Vela pulsar, as well as an unpulsed flux from the Vela region. The pulsed emission consists of two peaks, one following the radio peak by about 13 msec, and the other 0.4 period after the first. The luminosity of the pulsed emission above 100 MeV from Vela is about 0.1 that of the pulsar NP0532 in the Crab nebula, whereas the pulsed emission from Vela at optical wavelengths is less than 0.0004 that from the Crab. The relatively high intensity of the pulsed gamma-ray emission and the double peak structure, compared to the single pulse in the radio emission, suggests that the high energy gamma-ray pulsar emission may be produced under different conditions from those found at lower energies.

  17. METHODS OF DEALING WITH VALUES BELOW THE LIMIT OF DETECTION USING SAS

    Science.gov (United States)

    Due to limitations of chemical analysis procedures, small concentrations cannot be precisely measured. These concentrations are said to be below the limit of detection (LOD). In statistical analyses, these values are often censored and substituted with a constant value, such ...

  18. Radisson SAS-i hotellis avatakse kunstinäitus "Kujund"

    Index Scriptorium Estoniae

    2006-01-01

    Kuuelt eri põlvkonna kunstnikult aastatest 1996-2006 pärit maalide, joonistuste ja fotode näitus hotelli II korruse konverentsikeskuses 17. maist kuni 3. juulini 2006. Näituse koostas August Künnapu

  19. SAS 2 observations of the earth albedo gamma radiation above 35 MeV

    Science.gov (United States)

    Thompson, D. J.; Simpson, G. A.; Ozel, M. E.

    1981-01-01

    The earth albedo gamma radiation above 35 MeV in the equatorial region is investigated using observations from the second Small Astronomy Satellite. The zenith angle distribution of the gamma radiation has a peak toward the horizon which is about an order of magnitude more intense than the radiation coming from the nadir, and nearly two orders of magnitude more intense than the gamma radiation from most parts of the sky. The gamma radiation originating from the western horizon is a factor of four more intense than the radiation from the eastern horizon and a factor of three more intense than that from the northern and southern directions. This reflects the geomagnetic effects on the incident cosmic rays whose interactions produce the albedo gamma rays. The variation of the upcoming gamma ray intensity with vertical cutoff rigidity is consistent with the empirical relationship found by Gur'yan et al. (1979).

  20. Delineating Bukit Bunuh impact crater boundary by geophysical and geotechnical investigation

    Science.gov (United States)

    Azwin, I. N.; Rosli, S.; Mokhtar, S.; Nordiana, M. M.; Ragu, R. R.; Mark, J.

    2015-03-01

    Evidences of crater morphology and shock metamorphism in Bukit Bunuh, Lenggong, Malaysia were found during the archaeological research conducted by the Centre for Global Archaeological Research Malaysia, Universiti Sains Malaysia. In order to register Bukit Bunuh as one of the world meteorite impact site, detailed studies are needed to verify the boundary of the crater accordingly. Geophysical study was conducted utilising the seismic refraction and 2-D electrical resistivity method. Seismic refraction survey was done using ABEM MK8 24 channel seismograph with 14Hz geophones and 40kg weight drop while 2-D electrical resistivity survey was performed using ABEM SAS4000 Terrameter and ES10-64C electrode selector with pole-dipole array. Bedrock depths were digitized from the sections obtained. The produced bedrock topography map shows that there is low bedrock level circulated by high elevated bedrock and interpreted as crater and rim respectively with diameter approximately 8km. There are also few spots of high elevated bedrock appear at the centre of the crater which interpreted as rebounds zone. Generally, the research area is divided into two layers where the first layer with velocity 400-1100 m/s and resistivity value of 10-800 Om predominantly consists of alluvium mix with gravel and boulders. Second layer represents granitic bedrock with depth of 5-50m having velocity >2100 m/s and resistivity value of >1500 Om. This research is strengthen by good correlation between geophysical data and geotechnical borehole records executed inside and outside of the crater, on the rim, as well as at the rebound area.

  1. Chronicle of Bukit Bunuh for possible complex impact crater by 2-D resistivity imaging (2-DERI) with geotechnical borehole records

    Science.gov (United States)

    Jinmin, M.; Saad, R.; Saidin, M.; Ismail, N. A.

    2015-03-01

    A 2-D resistivity imaging (2-DERI) study was conducted at Bukit Bunuh, Lenggong, Perak. Archaeological Global Research Centre, Universiti Sains Malaysia shows the field evidence of shock metamorphisms (suevite breccia) and crater morphology at Bukit Bunuh. A regional 2-DERI study focusing at Bukit Bunuh to identify the features of subsurface and detail study was then executed to verify boundary of the crater with the rebound effects at Bukit Bunuh which covered approximately 132.25 km2. 2-DERI survey used resistivity equipment by ABEM SAS4000 Terrameter and ES10-64C electrode slector with pole-dipole array. The survey lines were carried out using `roll-along' technique. The data were processed and analysed using RES2DINV, Excel and Surfer software to obtain resistivity results for qualitative interpretations. Bedrock depths were digitized from section by sections obtained. 2-DERI results gives both regional and detail study shows that the study area was divided into two main zones, overburden consists of alluvium mix with boulders embedded with resistivity value of 10-800 Ωm and granitic bedrock with resistivity value of >1500 Ωm and depth 5-50 m. The low level bedrock was circulated by high level bedrock (crater rim) was formed at the same area with few spots of high level bedrock which appeared at the centre of the rim which suspected as rebound zones (R). Assimilations of 2-DERI with boreholes are successful give valid and reliable results. The results of the study indicates geophysical method are capable to retrieve evidence of meteorite impact subsurface of the studied area.

  2. Electrical imaging of the groundwater aquifer at Banting, Selangor, Malaysia

    Science.gov (United States)

    Hamzah, Umar; Yaacup, Rahman; Samsudin, Abdul Rahim; Ayub, Mohd Shahid

    2006-04-01

    A geophysical study was carried out in the Banting area of Malaysia to delineate groundwater aquifer and marine clay layer of the alluvial Quaternary deposits of Beruas and Gula Formations. The Beruas Formation is formed by peat and clayey materials as well as silt and sands, whereas the Gula Formation consists of clay, silt, sand and gravels. Both Formations were deposited on top of the Carboniferous shale of the Kenny Hill Formation. A 2-D geoelectrical resistivity technique was used. Resistivity measurement was carried out using an ABEM SAS 4000 Terrameter. The 2-D resistivity data of subsurface material for each survey line was calculated through inverse modelling and then compared with borehole data. The resistivity images of all the subsurface material below the survey lines show similar pattern of continuous structure of layering or layers with some lenses with resistivity ranging from 0.1 to 50 Ωm. The upper layer shows resistivity values ranging from 0.1 to 10 Ωm, representing a clay horizon with a thickness up to 45 m. The second layer with depth varies from 45 to 70 m below surface and has resistivity values ranging from 10 to 30 Ωm. Borehole data indicate coarse sand with some gravels for this layer, which is also the groundwater aquifer in the study area. The lowermost layer at a depth of 70 m below ground level shows resistivity values ranging from 30-50 Ωm and can be correlated with metasedimentary rocks consisting of shale and metaquartzite.

  3. Effects of Soil Moisture Content on Groundwater Electrical Resistivity Values in Irrigation Paddy Scheme, Tanjong Karang, Malaysia

    Directory of Open Access Journals (Sweden)

    Nurmala Sari

    2014-01-01

    Full Text Available Electrical Resistivity Tomography (ERT analyses have been conducted in Irrigation Paddy Scheme, Tanjong Karang, Malaysia as part of investigation on groundwater potential aquifer to provide an alternative water resource for paddy irrigation. Based on recent studies on groundwater resistivity in paddy field, irrigation system mentioned as soil moisture content was observed to affect the value of electrical resistivity and subsurface geological profile resulted from ERT analysis. The objective of this study was to proof any correlation between soil moisture content and electrical resistivity values and to determine at what level of soil moisture content which will be the best condition to conduct ERT survey. ERT analysis was conducted by using ABEM Terrameter SAS 4000 of Wenner-Schlumberger array with 5.0 meter and 10.0 meter for minimum and maximum electrode spacing. Visually, based on subsurface geological profile resulted from ERT analysis soil moisture content affected (changed electrical resistivity values. With all different treatments of soil moisture ranged from 16.96% to 27.50%, electrical resistivity values decreased in certain points and in certain depth along with the increase of soil moisture content. This was proofed by ANOVA and Duncan’s multiple range tests showing that Pr > F value was less than 0.0001. Further on Chi-square test showed that at soil moisture level of 22.54%, it was the best condition which gave more correct counts of electrical resistivity values compared to well lithology. This was assumed to be the best condition to conduct ERT survey.

  4. Investigation of groundwater in parts of Ndokwa District in Nigeria using geophysical logging and electrical resistivity methods: Implications for groundwater exploration

    Science.gov (United States)

    Anomohanran, Ochuko; Ofomola, Merrious Oviri; Okocha, Fredrick Ogochukwu

    2017-05-01

    Groundwater study involving the application of geophysical logging and vertical electrical sounding (VES) methods was carried out in parts of Ndokwa area of Delta State, Nigeria. The objective was to delineate the geological situation and the groundwater condition of the area. The geophysical logging of a drilled well and thirty VESs of the Schlumberger configuration were executed in this study using the Abem SAS 1000/4000 Terrameter. The result of the lithological study from the drilled well showed that the subsurface formation consist of lateritic topsoil, very fine sand, clayey fine sand, fine and medium grain sand, coarse sand, medium coarse sand and very coarse sand. The interpretation of the vertical electrical sounding data using a combination of curve matching and Win Resist computer iteration showed a close correlation with the well record. The result revealed the presence of four geoelectric layers with the aquifer identified to be in the fourth layer and having resistivity which ranged from 480 to 11,904 Ωm, while the depth ranged between 17.8 and 38.8 m. The analysis of the geophysical logging revealed that the average value of the electrical conductivity and the total dissolved solid of the groundwater in the aquifer were obtained as 229 μS/cm and 149 mg/cm3 respectively. These results indicate that the groundwater is within the permissible limit set by the Standard Organization of Nigeria for potable water which is 1000 μS/cm for electrical conductivity and 500 mg/cm3 for total dissolved solid. The fourth layer was therefore identified as the potential non conductive zone suitable for groundwater development in the study area.

  5. Delineating Bukit Bunuh impact crater boundary by geophysical and geotechnical investigation

    Energy Technology Data Exchange (ETDEWEB)

    Azwin, I. N., E-mail: nurazwinismail@yahoo.com; Rosli, S.; Nordiana, M. M.; Ragu, R. R.; Mark, J. [Geophysics Section, School of Physics, Universiti Sains Malaysia, 11800 USM, Penang (Malaysia); Mokhtar, S. [Centre for Global Archaeological Research Malaysia, 11800 USM, Penang (Malaysia)

    2015-03-30

    Evidences of crater morphology and shock metamorphism in Bukit Bunuh, Lenggong, Malaysia were found during the archaeological research conducted by the Centre for Global Archaeological Research Malaysia, Universiti Sains Malaysia. In order to register Bukit Bunuh as one of the world meteorite impact site, detailed studies are needed to verify the boundary of the crater accordingly. Geophysical study was conducted utilising the seismic refraction and 2-D electrical resistivity method. Seismic refraction survey was done using ABEM MK8 24 channel seismograph with 14Hz geophones and 40kg weight drop while 2-D electrical resistivity survey was performed using ABEM SAS4000 Terrameter and ES10-64C electrode selector with pole-dipole array. Bedrock depths were digitized from the sections obtained. The produced bedrock topography map shows that there is low bedrock level circulated by high elevated bedrock and interpreted as crater and rim respectively with diameter approximately 8km. There are also few spots of high elevated bedrock appear at the centre of the crater which interpreted as rebounds zone. Generally, the research area is divided into two layers where the first layer with velocity 400-1100 m/s and resistivity value of 10-800 Om predominantly consists of alluvium mix with gravel and boulders. Second layer represents granitic bedrock with depth of 5-50m having velocity >2100 m/s and resistivity value of >1500 Om. This research is strengthen by good correlation between geophysical data and geotechnical borehole records executed inside and outside of the crater, on the rim, as well as at the rebound area.

  6. SAS 优化紫外诱变菌发酵产酶培养基及酶性质探讨%Study on optimization of UV-induced mutation fermentation medium for cellulase by SAS and its crude properties

    Institute of Scientific and Technical Information of China (English)

    米芳; 马英辉; 高锦明

    2010-01-01

    利用SAS中的Plackett-Burman二水平设计法成功地选取了对宇佐美曲霉固态发酵小麦秸秆产纤维素酶影响显著的4个因素(初始pH、尿素浓度、含水量和C源比例),并依据Box-Benhnken设计原则进行响应面回归模型分析(RSA),得出最佳的水平为:培养基初始pH为6.2、尿素浓度为1.54%、含水量为1.25:1、秸秆与麸皮的比例为4.6:5.4,在此务件下CMC酶和FPU酶的酶活分别达到1224.7u/g和254.5u/g;对粗酶液的酶学性质研究发现,CMC酶和FPU酶的最适作用pH分别为4.5和6.0,最适温度为65℃和50℃.

  7. Algunos elementos de la metodología Six sigma aplicados a la empresa Indalar S.A.S.

    OpenAIRE

    Aristizabal Salazar, Vanessa; Zuluaga Muñoz, William

    2013-01-01

    Este artículo explica y argumenta una propuesta de algunos elementos de la metodología Six Sigma: su historia y herramientas para la implementación y el desarrollo de la misma en una pequeña empresa y su viabilidad para mejorar los procesos de entrega a los proveedores. Artículo de investigación de la Facultad de Ciencias Administrativas Económicas y Contables, Julio 26 de 2013.

  8. SAS2H Generated Isotopic Concentrations For B&W 15X15 PWR Assembly (SCPB:N/A)

    Energy Technology Data Exchange (ETDEWEB)

    J.W. Davis

    1996-08-29

    This analysis is prepared by the Mined Geologic Disposal System (MGDS) Waste Package Development Department (WPDD) to provide pressurized water reactor (PWR) isotopic composition data as a function of time for use in criticality analyses. The objectives of this evaluation are to generate burnup and decay dependant isotopic inventories and to provide these inventories in a form which can easily be utilized in subsequent criticality calculations.

  9. Decentralized models of agricultural marketing as a strategy for social inclusion in Colombia: the case Exofruit SAS

    Directory of Open Access Journals (Sweden)

    Francisco Javier Arias Vargas

    2015-09-01

    Full Text Available This paper analyzes a model of decentralized marketing cape gooseberry (Physalis peruviana as an alternative to traditional wholesale channels; where brokers obtain higher profits; while farmers receive little profit for their product and the customer receives an expensive product. The investigative process development for nine months under a descriptive exploratory approach to data collection and triangulation of it to build the case. The project currently benefits 40 farmers; victims of armed conflict in the village of Mesopotamia Antioquia Union have joined the project, which has particularities like organic production of 1.2 tons per month of product, recovery of abandoned land; and equitable distribution of profits and the way for negotiations between farmers and the seller as a new proposal of peasant association.

  10. Exact logistic regression and its performance to SAS system%精确logistic回归及其SAS应用程序

    Institute of Scientific and Technical Information of China (English)

    刘启军; 曾庆; 周燕荣

    2003-01-01

    目的精确logistic回归在最大似然法估计结果不可靠或者不存在情况下,作为传统logistic回归的一种补充方法可适用于小样本资料、资料结构不平衡及高度分层资料.方法对37例乳腺癌患者术后预后资料采用SAS进行精确logistic回归分析.结果发现组织学分级、淋巴结转移两因素对乳腺癌的术后预后具有统计学意义.结论在样本量很小,最大似然法估计无效的情况下,精确logistic回归是一种极好的分析手段.

  11. Plan de negocios Centro de Entretenimiento de Alta Tecnología Realgame S.A.S

    OpenAIRE

    2012-01-01

    El proyecto pretende realizar un plan de negocio que garantice la viabilidad de la puesta en marcha de Realgame, donde contextualiza y estructura los estudios necesarios para la conformación de la empresa como un centro de entretenimiento de alta tecnología en la ciudad de Bogotá, que inicialmente ofrezca video juegos en 3D y posteriormente se pueda incursionar en la tecnología 4D y la realidad virtual

  12. Increasing the Number of Replications in Item Response Theory Simulations: Automation through SAS and Disk Operating System

    Science.gov (United States)

    Gagne, Phill; Furlow, Carolyn; Ross, Terris

    2009-01-01

    In item response theory (IRT) simulation research, it is often necessary to use one software package for data generation and a second software package to conduct the IRT analysis. Because this can substantially slow down the simulation process, it is sometimes offered as a justification for using very few replications. This article provides…

  13. 香荚兰种苗繁殖试验的SAS分析%SAS Analysis of Vanilla Seedling Propagation Experiments

    Institute of Scientific and Technical Information of China (English)

    陈文贤

    2003-01-01

    采用国际通用统计软件SAS对香荚兰种苗繁殖在土壤pH值一定及母蔓长度一定时,母蔓在育苗后不同时间的出根、出芽率试验结果进行统计分析.结果表明:当土壤pH值为7.0、母蔓长度为30 cm时,母蔓在育苗后不同时间的出根、出芽率较高.

  14. [Intermediate-term follow-up of surgically managed tendinosis calcarea (calcifying subacromion syndrome--SAS) of the shoulder joint].

    Science.gov (United States)

    Rubenthaler, F; Wittenberg, R H

    1997-01-01

    Investigation of clinical und ultrasonographical results after operatively treated calcifying tendinitis. 131 patients with calcifying tendinitis were treated by surgical decompression and, if necessary and possible, calcific deposit removal. 93% of these patients were clinically and ultrasonographically examined after an average time of 4 years and 5 months. Pain rating on a visual analogue scale 0-no pain to 10-maximum pain was 8.7 before surgery and 1.4 at follow-up. 88% of the patients rated the operation excellent or good. The Constant Score results corresponded to the average results of a normal population (100.3). At the time of examination in 16.4% of the cases new calcific deposits could be discovered. According to the clinical results operative treatment shows good and excellent results in a high degree even after unsuccessful non-operative therapy.

  15. 基于SAS的web文本分类模型研究%WEB TEXT CLASSIFICATION MODEL STUDY BASED ON SAS

    Institute of Scientific and Technical Information of China (English)

    向来生; 孙威; 刘希玉

    2016-01-01

    通过建立模型对电商企业的客户查询信息进行文本分类分析,帮助企业掌握用户的消费习惯,同时帮助用户及时找到需要的商品。本文首先获取客户查询数据并对该文本数据进行预处理,利用改进的TF-IDF方法获得文本特征向量,最后结合朴素贝叶斯文本分类及半监督的EM迭代算法建立分类模型,并应用各种标准对模型进行评估,验证模型的有效性。多类别文本集选取文本特征时,关键词权值容易产生波动,本研究改进关键词权值计算公式来改善分类结果。实验结果表明分类器具有良好的分类效果。%In this paper,we establish a model to analysis business enterprise customer query information for text classification to help e-commerce companies control the userˊs spending habits,and help users to find their needed goods. This study accesses to customer inquiry data and preprocesses these text data firstly. And then,the improved TF - IDF principle is applied to obtain the text feature vectors. Finally,this study establishes the classification model combining the Naive Bayes text classification and the semi-supervised EM iterative algorithm, and uses various criteria to evaluate the model. When facing multi - class text classification feature selection, keyword weights prone to great volatility. This study improves the keyword weight calculation formula to perfect the classification results. The experimental results show that classification has good classification effect.

  16. Facilitating Configural Processing Within the Audit Team: An Additional Benefit of the SAS 99 Fraud Brainstorming Session

    OpenAIRE

    Fay, Rebecca G

    2011-01-01

    This study considers the ability of the audit team to configurally process information, that is, to piece together information cues held by individual team members and recognize the underlying pattern in the information. It also examines how the hierarchical structure of the audit team impacts the teamâ s ability to process information and affects the quality of decisions made by the team. The study also considers the ability of a specific audit procedure, the fraud brainstorming session req...

  17. Plan de Mejoramiento Para la Empresa AAA PH SAS Asistencia y Administración A Propiedad Horizontal

    OpenAIRE

    Quintana Tamayo, Johan Sebastian

    2012-01-01

    La oportunidad del mercado se define como la necesidad de abarcar el mercado de la administración de propiedad horizontal y la venta de copropiedades. Mercado que se encuentra en crecimiento en Bogotá. Enfocándonos en los estratos 5 y 6 de las localidades de Usaquén, Suba y Chapinero. En la actualidad son muy pocas las empresas especializadas en la administración de propiedad horizontal. Existen muchas empresas que intentan abarcar este mercado, pero no hay estrategias de fondo que permitan l...

  18. 海量存储新丁——Seagate Barracuda ES2 7.2K SAS 1TB

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    在服务器中,SAS硬盘几乎已经成为了标准配置。对于服务器数据存储来说,硬盘在很大程度上决定了文件服务器、数据库服务器的性能。在我们所测试的中高端服务器里,Seagatete司的Cheetah系列硬盘是最为常见的。在SCSI硬盘中,Cheetah系列产品就素以高性能而著称,无论是其10000rpm还是15000rpm产品,这一系列产品较其他竞争对手都有着不小的性能优势。不过在海量数据存储应用方面,高速硬盘却有着不小的劣势。

  19. Montelukast as Add-On Therapy to Inhaled Corticosteroids in the Management of Asthma (The SAS Trial

    Directory of Open Access Journals (Sweden)

    J Mark FitzGerald

    2009-01-01

    Full Text Available AIM: To evaluate the effectiveness of montelukast as add-on therapy for asthmatic patients who remain uncontrolled with low, moderate or high doses of inhaled corticosteroid monotherapy.

  20. STOCHASTIC HUMAN EXPOSURE AND DOSE SIMULATION MODEL FOR THE WOOD PRESERVATIVE SCENARIO (SHEDS-WOOD), VERSION 2 MODEL SAS CODE

    Science.gov (United States)

    Concerns have been raised regarding the safety of young children contacting arsenic and chromium residues while playing on and around Chromated Copper Arsenate (CCA) treated wood playground structures and decks. Although CCA registrants voluntarily canceled treated wood for resi...

  1. AnovArray: a set of SAS macros for the analysis of variance of gene expression data

    Directory of Open Access Journals (Sweden)

    Renard Jean-Paul

    2005-06-01

    Full Text Available Abstract Background Analysis of variance is a powerful approach to identify differentially expressed genes in a complex experimental design for microarray and macroarray data. The advantage of the anova model is the possibility to evaluate multiple sources of variation in an experiment. Results AnovArray is a package implementing ANOVA for gene expression data using SAS® statistical software. The originality of the package is 1 to quantify the different sources of variation on all genes together, 2 to provide a quality control of the model, 3 to propose two models for a gene's variance estimation and to perform a correction for multiple comparisons. Conclusion AnovArray is freely available at http://www-mig.jouy.inra.fr/stat/AnovArray and requires only SAS® statistical software.

  2. Increasing the Number of Replications in Item Response Theory Simulations: Automation through SAS and Disk Operating System

    Science.gov (United States)

    Gagne, Phill; Furlow, Carolyn; Ross, Terris

    2009-01-01

    In item response theory (IRT) simulation research, it is often necessary to use one software package for data generation and a second software package to conduct the IRT analysis. Because this can substantially slow down the simulation process, it is sometimes offered as a justification for using very few replications. This article provides…

  3. Geoelectrical investigation and hydrochemical analysis of ...

    African Journals Online (AJOL)

    hope&shola

    2011-10-04

    Oct 4, 2011 ... with an abundant surface and groundwater resources, but the later is about .... For every measurement taken, the terrameter took three readings since a ... A Philip analog pH meter was used to monitor the pH of all water samples, while the .... it could lead to skin infection, domestic cholera and dysentery.

  4. Underground water and pollution vulnerability assessment of lower Imo sedimentary basin of South-eastern Nigeria: A case study of Nwangele Local Government Area of Imo state, Nigeria

    Directory of Open Access Journals (Sweden)

    Onunkwo – A, A

    2012-06-01

    Full Text Available Water exploitation and population explosion are two major problems facing Nwangele Local Government. This study was therefore predicated on these problems to assess the underground water and pollution vulnerability of the study area. The method of study involves literature survey of previous work done in Imo River sedimentary basin and other works considered necessary for the study. A total of ten (10 vertical electricity soundings (VES was conducted for data generation using terrameter 300 SAS employing Schlumberger configuration. Aquifer (sands from boreholes within three (3 communities and ten (10 water samples were collected and used for statistical and geochemical analysis. The result shows that the lithology is made of sand, silt sand, clay and shale. Three (3 aquifer systems exits in the area confined, semi confined and unconfined aquifers, these occur as upper (33.5m, middle (82m and lower (102 to 115m aquifers. The lithology comprises 4 to 6 layers with water bearing bed occurring at the fifth layer. Average aquifer thickness measured 38 metres. Multiaquifer system exists in some localities. Hydraulic conductivity values range from 25.6m/day to 28.9m/day, transmissivity ranges from 450.842/day to 111.7m2/day while the storativity values ranges from 0.468 x 10-5 to 1.13 x 10-5, all indicate aquifer of good yield. Aquifer thickness ranges from 12.5 to 45m. The water chemistry is neutral, mildly acidic to mildly alkaline. The underground water is of calcium by carbonate type (CaHCO3 fresh and ideal for consumption, irrigation and laundry industry. None of the constituents fell short of WHO (1984 standard . Environmental pollution is only confined to upper aquifer. It is recommended that the three aquifer horizons can be tapped at the depth range of 18 to 102 metres. Multiple screen should be employed where there are more than one aquifer horizon. It is advisable that down the hole electric logging be conducted prior to the installation of

  5. Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care

    Directory of Open Access Journals (Sweden)

    Vekemans Johan

    2011-08-01

    Full Text Available Abstract Background An effective malaria vaccine, deployed in conjunction with other malaria interventions, is likely to substantially reduce the malaria burden. Efficacy against severe malaria will be a key driver for decisions on implementation. An initial study of an RTS, S vaccine candidate showed promising efficacy against severe malaria in children in Mozambique. Further evidence of its protective efficacy will be gained in a pivotal, multi-centre, phase III study. This paper describes the case definitions of severe malaria used in this study and the programme for standardized assessment of severe malaria according to the case definition. Methods Case definitions of severe malaria were developed from a literature review and a consensus meeting of expert consultants and the RTS, S Clinical Trial Partnership Committee, in collaboration with the World Health Organization and the Malaria Clinical Trials Alliance. The same groups, with input from an Independent Data Monitoring Committee, developed and implemented a programme for standardized data collection. The case definitions developed reflect the typical presentations of severe malaria in African hospitals. Markers of disease severity were chosen on the basis of their association with poor outcome, occurrence in a significant proportion of cases and on an ability to standardize their measurement across research centres. For the primary case definition, one or more clinical and/or laboratory markers of disease severity have to be present, four major co-morbidities (pneumonia, meningitis, bacteraemia or gastroenteritis with severe dehydration are excluded, and a Plasmodium falciparum parasite density threshold is introduced, in order to maximize the specificity of the case definition. Secondary case definitions allow inclusion of co-morbidities and/or allow for the presence of parasitaemia at any density. The programmatic implementation of standardized case assessment included a clinical algorithm for evaluating seriously sick children, improvements to care delivery and a robust training and evaluation programme for clinicians. Conclusions The case definition developed for the pivotal phase III RTS, S vaccine study is consistent with WHO recommendations, is locally applicable and appropriately balances sensitivity and specificity in the diagnosis of severe malaria. Processes set up to standardize severe malaria data collection will allow robust assessment of the efficacy of the RTS, S vaccine against severe malaria, strengthen local capacity and benefit patient care for subjects in the trial. Trial registration Clinicaltrials.gov NCT00866619

  6. SAS的IML过程在Markov链预测中的应用%A application of the IML process in the SAS system on Markov chain forecasting

    Institute of Scientific and Technical Information of China (English)

    张睿玲; 周怡; 沈逸雄

    2004-01-01

    本文以医学实例分析介绍了Markov链的SAS程序实现方法,应用SAS的IML过程进行Markov链的预测,结果齐全,过程简单,使用方便,为Markov链的预测提供了有力的分析工具.

  7. Development and psychometric properties of the Suicidality : Treatment Occurring in Paediatrics (STOP) Suicidality Assessment Scale (STOP-SAS) in children and adolescents

    NARCIS (Netherlands)

    Flamarique, I.; Santosh, P.; Zuddas, A.; Arango, C.; Purper-Ouakil, D.; Hoekstra, P. J.; Coghill, D.; Schulze, U.; Dittmann, R. W.; Buitelaar, J. K.; Lievesley, K.; Frongia, R.; Llorente, C.; Mendez, I.; Sala, R.; Fiori, F.; Castro-Fornieles, J.

    2016-01-01

    Background: To create a self-reported, internet-based questionnaire for the assessment of suicide risk in children and adolescents. Methods: As part of the EU project `Suicidality: Treatment Occurring in Paediatrics' (STOP project), we developed web-based Patient Reported Outcome Measures (PROMs) fo

  8. Development and psychometric properties of the Suicidality: Treatment Occurring in Paediatrics (STOP) Suicidality Assessment Scale (STOP-SAS) in children and adolescents

    NARCIS (Netherlands)

    Flamarique, I.; Santosh, P.; Zuddas, A.; Arango, C.; Purper-Ouakil, D.; Hoekstra, P.J.; Coghill, D.; Schulze, U.; Dittmann, R.W.; Buitelaar, J.K.; Lievesley, K.; Frongia, R.; Llorente, C.; Mendez, I.; Sala, R.; Fiori, F.; Castro-Fornieles, J.

    2016-01-01

    BACKGROUND: To create a self-reported, internet-based questionnaire for the assessment of suicide risk in children and adolescents. METHODS: As part of the EU project 'Suicidality: Treatment Occurring in Paediatrics' (STOP project), we developed web-based Patient Reported Outcome Measures (PROMs)

  9. Development and psychometric properties of the Suicidality : Treatment Occurring in Paediatrics (STOP) Suicidality Assessment Scale (STOP-SAS) in children and adolescents

    NARCIS (Netherlands)

    Flamarique, I.; Santosh, P.; Zuddas, A.; Arango, C.; Purper-Ouakil, D.; Hoekstra, P. J.; Coghill, D.; Schulze, U.; Dittmann, R. W.; Buitelaar, J. K.; Lievesley, K.; Frongia, R.; Llorente, C.; Mendez, I.; Sala, R.; Fiori, F.; Castro-Fornieles, J.

    2016-01-01

    Background: To create a self-reported, internet-based questionnaire for the assessment of suicide risk in children and adolescents. Methods: As part of the EU project `Suicidality: Treatment Occurring in Paediatrics' (STOP project), we developed web-based Patient Reported Outcome Measures (PROMs)

  10. 基于Pearson相关系数Meta分析在SAS程序中的实现%Meta-Analysis of Correlation Coefficient and Its Realization with SAS

    Institute of Scientific and Technical Information of China (English)

    祁娟; 张丕德; 李河

    2013-01-01

    目的 介绍Pearson相关系数的Meta分析方法及其在SAS软件中的实现.方法 以实例数据为例,编写SAS程序,运行出结果;将SAS运行结果和实例中应用软件结果进行比较.结果 SAS软件运行结果和实例中应用软件结果无差异.结论 本研究编写的SAS程序可以实现相关系数的Meta分析.

  11. Desarrollo de un modelo de negocio para la empresa Agroindustrias Villalonso S.A.S. y su proyecto de reforestación comercial de caucho natural

    OpenAIRE

    Quesada Orejarena, Oscar Javier

    2016-01-01

    El caucho natural y su proceso de transformación industrial es una cadena que presenta grandes potencialidades agroecológicas en el país, genera empleo rural productivo, construye capital y contribuye con el medio ambiente, razones que motivaron al autor a investigar los aspectos técnicos que el inversionista debe tener presente al momento de emprender un proyecto de reforestación comercial de caucho -- El caso de estudio se desarrolló para la microempresa Agroindustrias Villalonso, ubicada e...

  12. Un modelo de gestión de la creatividad que promueva la innovación en las organizaciones: caso Griffith Foods S.A.S.

    OpenAIRE

    Mejía Tamayo, Erika Milena; Sierra Sáenz, Martha Cecilia

    2016-01-01

    En la actualidad las organizaciones se encuentran inmersas en un ambiente en extremo cambiante y competitivo que las obliga a estar siempre a la vanguardia y hacer de la innovación un proceso sistemático, que se alimenta no solo de las prospectivas científico-tecnológicas y la inteligencia competitiva, sino también del potencial creativo de su gente -- Pero ¿cómo se potencializa, entonces, la innovación en las organizaciones a partir de la gestión de la creatividad con sus colaboradores? Ése ...

  13. Escala de actitud sexual de R.F. Valois (S.A.S., 1980): estudio factorial de la adaptación castellana

    OpenAIRE

    Jiménez Gómez, Fernando; Sánchez Crespo, Guadalupe; Merino Barragán, Vicente

    1999-01-01

    Se analiza la adaptación que la Unidad de Investigación en Evaluación Psicológica de la Facultad de Psicología dela Universidad de Salamanca ha realizado de la escala de actitud sexual de R.F. Valois.

  14. SAS solution structures of the apo and Mg2+/BeF3(-)-bound receiver domain of DctD from Sinorhizobium meliloti.

    Science.gov (United States)

    Nixon, B Tracy; Yennawar, Hemant P; Doucleff, Michaeleen; Pelton, Jeffrey G; Wemmer, David E; Krueger, Susan; Kondrashkina, Elena

    2005-10-25

    Two-component signal transduction is the predominant information processing mechanism in prokaryotes and is also present in single-cell eukaryotes and higher plants. A phosphorylation-based switch is commonly used to activate as many as 40 different types of output domains in more than 6000 two-component response regulators that can be identified in the sequence databases. Previous biochemical and crystallographic studies showed that phosphorylation of the two-component receiver domain of DctD causes a switch between alternative dimeric forms, but it was unclear from the crystal lattice of the activated protein precisely which of four possible dimeric configurations is the biologically relevant one [Park, S., et al. (2002) FASEB J. 16, 1964-1966]. Here we report solution structures of the apo and activated DctD receiver domain derived from small angle scattering data. The apo dimer closely resembles that seen in the crystal structure, and the solution data for the activated protein eliminate two of the possible four dimeric conformations seen in the crystal lattice and strongly implicate one as the biologically relevant structure. These results corroborate the previously proposed model for how receiver domains regulate their downstream AAA+ ATPase domains.

  15. Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care.

    Science.gov (United States)

    Vekemans, Johan; Marsh, Kevin; Greenwood, Brian; Leach, Amanda; Kabore, William; Soulanoudjingar, Solange; Asante, Kwaku Poku; Ansong, Daniel; Evans, Jennifer; Sacarlal, Jahit; Bejon, Philip; Kamthunzi, Portia; Salim, Nahya; Njuguna, Patricia; Hamel, Mary J; Otieno, Walter; Gesase, Samwel; Schellenberg, David

    2011-08-04

    An effective malaria vaccine, deployed in conjunction with other malaria interventions, is likely to substantially reduce the malaria burden. Efficacy against severe malaria will be a key driver for decisions on implementation. An initial study of an RTS, S vaccine candidate showed promising efficacy against severe malaria in children in Mozambique. Further evidence of its protective efficacy will be gained in a pivotal, multi-centre, phase III study. This paper describes the case definitions of severe malaria used in this study and the programme for standardized assessment of severe malaria according to the case definition. Case definitions of severe malaria were developed from a literature review and a consensus meeting of expert consultants and the RTS, S Clinical Trial Partnership Committee, in collaboration with the World Health Organization and the Malaria Clinical Trials Alliance. The same groups, with input from an Independent Data Monitoring Committee, developed and implemented a programme for standardized data collection.The case definitions developed reflect the typical presentations of severe malaria in African hospitals. Markers of disease severity were chosen on the basis of their association with poor outcome, occurrence in a significant proportion of cases and on an ability to standardize their measurement across research centres. For the primary case definition, one or more clinical and/or laboratory markers of disease severity have to be present, four major co-morbidities (pneumonia, meningitis, bacteraemia or gastroenteritis with severe dehydration) are excluded, and a Plasmodium falciparum parasite density threshold is introduced, in order to maximize the specificity of the case definition. Secondary case definitions allow inclusion of co-morbidities and/or allow for the presence of parasitaemia at any density. The programmatic implementation of standardized case assessment included a clinical algorithm for evaluating seriously sick children, improvements to care delivery and a robust training and evaluation programme for clinicians. The case definition developed for the pivotal phase III RTS, S vaccine study is consistent with WHO recommendations, is locally applicable and appropriately balances sensitivity and specificity in the diagnosis of severe malaria. Processes set up to standardize severe malaria data collection will allow robust assessment of the efficacy of the RTS, S vaccine against severe malaria, strengthen local capacity and benefit patient care for subjects in the trial. Clinicaltrials.gov NCT00866619.

  16. Plan de negocios para la creación de una discoteca multicultural Exchange Cultural Meeting Point S.A.S.

    OpenAIRE

    Rivera Muñoz, Luis Orlando

    2013-01-01

    El documento contiene el plan de negocio para la creación de una discoteca multicultural, dirigida tanto a locales como extranjeros en la ciudad de Bogotá, orientada a la lucha contra la xenofobia y en aras al respeto por la diversidad cultural, la práctica de lenguas extranjeras y la globalización

  17. Conceptualización de una unidad de inteligencia de negocios en una empresa de tercerización de servicios : Caso IQ Outsourcing S.A.S.

    OpenAIRE

    Villamarín Gil, William Ancízar

    2015-01-01

    "Existen procesos en diferentes entidades privadas y públicas que implican un gran esfuerzo e inversión en levantamiento de información, implementación de soluciones, mantenimientos y gestión de recursos operativos, que al compararse con la misión de estas entidades no están muy relacionados con su negocio. Por otra parte, el tiempo requerido para llevar a cabo una iniciativa, depende de estos procesos en la medida en que se les presta atención y asignación de recursos. Algunos de estos pr...

  18. 利用SAS软件优化桑黄发酵培养基%SAS Application in Studies on Medium Optimization of Phellinus Linteus

    Institute of Scientific and Technical Information of China (English)

    林百全; 余晓斌

    2006-01-01

    利用SAS软件对桑黄菌的发酵培养基进行研究.首先,运用Plackett-Burman设计法筛选出影响粗多糖产量的主要因素,继而采用中心组合设计及响应面分析确定主要影响因子的最佳浓度.通过试验发现,当豆饼粉3.7%、玉米浆0.6%、CaCl20.27%时,胞外粗多糖产量达到最大值6.78 g/L,较优化前的5.24 g/L提高了29.4%.另外还对其胞外多糖含量、分子质量进行了测定.

  19. Vuong检验在临床研究中的应用及SAS实现%Clinical application and SAS implementation of Vuong test

    Institute of Scientific and Technical Information of China (English)

    唐欣然; 黄耀华; 王杨; 李卫

    2013-01-01

    目的 探讨用于传统回归与零膨胀回归模型选择的Vuong检验(简称V检验)SAS实现方法及应用.方法 介绍V检验的原理及方法并给出实现V检验的SAS宏程序,结合实例,将SAS宏的检验结果与Stata软件进行核对,证明宏程序的正确性.结果 应用实例中ZINB模型-2Log Likelihood为44 623,回归模型选择标准(Akaike Information Criterion)为44 665,BIC(Bayesian Information Criterion)为44 819,相比其他模型拟合效果最好;SAS宏程序对ZINB与负二项回归模型V检验结果为30.326 9,>1.96,数据分析应采用ZINB模型;Stata软件的输出V值为30.33,和宏程序检验结果一致.结论 V检验用于判断传统回归和零膨胀回归模型拟合的优劣;SAS宏程序可以实现V检验.

  20. Montaje de la gerencia de ventas para la firma AndiService Solutions R.L. S.A.S. para el año 2013

    OpenAIRE

    2012-01-01

    El informe define el montaje de la Gerencia de Ventas para la empresa AndiService Solutions R.L. para el año 2013, el cual esta diseñado en cuatro fases: planeación, organización, desarrollo y dirección de la fuerza de ventas. Posteriormente se incluye los sistemas de análisis que permiten la evaluación de ventas, costos y los niveles de rentabilidad, al igual que los mecanismos de evaluación de desempeño de la fuerza de ventas. Por último se presenta las conclusiones y recomendaciones que se...

  1. Definición de indicadores de desempeño de los ejecutivos de ventas de la empresa MABE Colombia SAS

    OpenAIRE

    Tobón Mesa, María Paulina; López Bedoya, Alejandro; Magíster en Administración de Empresas

    2011-01-01

    Este trabajo es una propuesta para la medición integral de la gestión comercial enfocada a la profesionalización de su fuerza de ventas. El objetivo es definir una alternativa para medir el desempeño de los ejecutivos de ventas basados en las competencias, de acuerdo a su cargo. Tradicionalmente la compañía ha enfocado sus esfuerzos en medir la gestión comercial a través de indicadores de output, es decir, ventas en unidades, ventas en pesos, recaudo y cobranza, entre otros, dejando a un lado...

  2. Definición de indicadores de desempeño de los ejecutivos de ventas de la empresa MABE Colombia SAS

    OpenAIRE

    Tobón Mesa, María Paulina; López Bedoya, Alejandro; Magíster en Administración de Empresas

    2011-01-01

    Este trabajo es una propuesta para la medición integral de la gestión comercial enfocada a la profesionalización de su fuerza de ventas. El objetivo es definir una alternativa para medir el desempeño de los ejecutivos de ventas basados en las competencias, de acuerdo a su cargo. Tradicionalmente la compañía ha enfocado sus esfuerzos en medir la gestión comercial a través de indicadores de output, es decir, ventas en unidades, ventas en pesos, recaudo y cobranza, entre otros, dejando a un lado...

  3. Development and psychometric properties of the Suicidality : Treatment Occurring in Paediatrics (STOP) Suicidality Assessment Scale (STOP-SAS) in children and adolescents

    NARCIS (Netherlands)

    Flamarique, I.; Santosh, P.; Zuddas, A.; Arango, C.; Purper-Ouakil, D.; Hoekstra, P. J.; Coghill, D.; Schulze, U.; Dittmann, R. W.; Buitelaar, J. K.; Lievesley, K.; Frongia, R.; Llorente, C.; Mendez, I.; Sala, R.; Fiori, F.; Castro-Fornieles, J.

    2016-01-01

    Background: To create a self-reported, internet-based questionnaire for the assessment of suicide risk in children and adolescents. Methods: As part of the EU project `Suicidality: Treatment Occurring in Paediatrics' (STOP project), we developed web-based Patient Reported Outcome Measures (PROMs) fo

  4. Development and psychometric properties of the Suicidality: Treatment Occurring in Paediatrics (STOP) Suicidality Assessment Scale (STOP-SAS) in children and adolescents

    NARCIS (Netherlands)

    Flamarique, I.; Santosh, P.; Zuddas, A.; Arango, C.; Purper-Ouakil, D.; Hoekstra, P.J.; Coghill, D.; Schulze, U.; Dittmann, R.W.; Buitelaar, J.K.; Lievesley, K.; Frongia, R.; Llorente, C.; Mendez, I.; Sala, R.; Fiori, F.; Castro-Fornieles, J.

    2016-01-01

    BACKGROUND: To create a self-reported, internet-based questionnaire for the assessment of suicide risk in children and adolescents. METHODS: As part of the EU project 'Suicidality: Treatment Occurring in Paediatrics' (STOP project), we developed web-based Patient Reported Outcome Measures (PROMs) fo

  5. Desarrollo de una nueva línea de negocio para Aromáticos de Occidente S.A.S

    OpenAIRE

    Alvarez Escobar, María Fernanda

    2011-01-01

    Este proyecto plantea una nueva línea de negocio para la empresa Aromáticos de Occidente (Aroc), con la cual se busca diversificar el mercado de esta empresa por medio de la elaboración de propuestas comerciales orientadas a desarrollar fragancias que aromatizarán locales comerciales y/o oficinas, y dulces saborizados que identifiquen la marca. Se espera que estas fragancias y sabores generen experiencias sensoriales estimulantes para el sentido del olfato y del gusto, y asociaciones que cont...

  6. Modelos descentralizados de comercialización agropecuaria como estrategia para la inclusión social en Colombia: el caso Exofruit SAS

    Directory of Open Access Journals (Sweden)

    Francisco Javier Arias Vargas

    2015-01-01

    Full Text Available El presente trabajo analiza un modelo de comercialización descentralizada de uchuva (Physalis peruviana como una alternativa a los esquemas tradicionales mayoristas, dónde los intermediarios se llevan la mayor parte de la ganancias y dónde la ineficiencia del proceso termina trasladándose a los productores que reciben muy poco por su producción y al consumidor que termina adquiriendo el producto a unos costos elevados. El proceso investigativo se desarrolló durante nueve meses bajo un enfoque exploratorio descriptivo en la recolección de la información y triangulación de la misma para la construcción del caso. El proyecto beneficia actualmente a 40 productores agropecuarios, víctimas del conflicto armado de la vereda Mesopotamia del Municipio de la Unión Antioquia se han incorporado al proyecto, el cual presenta particularidades como la producción orgánica de 1,2 toneladas mensuales de producto, recuperación de terrenos abandonados, además de abordar la distribución equitativa de las ganancias y la forma de negociación entre productores y comercializador como una nueva propuesta para lograr asociatividad campesina.

  7. Diseño de un Modelo de Auditoría Postventa para la empresa Almacenes Hogar y Moda S.A.S

    OpenAIRE

    Flórez Pérez, Diego Fernando; Arboleda Marín, Johana María

    2016-01-01

    El servicio al cliente constituye un elemento primordial del cual depende el éxito y la permanencia de la organización en el mercado; siendo importante el papel realizado después de la venta, ya que al hacer seguimiento al cliente se puede generar una nueva compra, incluso fidelizarlo por años. Actualmente enla empresa Almacenes Hogar y Moda el área de servicio al cliente no cuenta con estructura definida y el nivel de comunicación con los procesos que intervienen en el servicio son deficient...

  8. SAS-2 observations of the diffuse gamma radiation in the galactic latitude interval 10 deg absolute b or equal to 90 deg

    Science.gov (United States)

    Fichtel, C. E.; Hartman, R. C.; Kniffen, D. A.; Thompson, D. J.; Oegelman, H. B.; Oezel, M. E.; Tuemer, T.

    1977-01-01

    An analysis of all of the second small astronomy satellite gamma-ray data for galactic latitudes with the absolute value of b 10 deg has shown that the intensity varies with galactic latitude, being larger near 10 deg than 90 deg. For energies above 100 MeV the gamma-ray data are consistent with a latitude distribution of the form I(b) = C sub 1 + C sub 2/sin b, with the second term being dominant. This result suggests that the radiation above 100 MeV is coming largely from local regions of the galactic disk. Between 35 and 100 MeV, a similar equation is also a good representation of the data, but here the two terms are comparable. These results indicate that the diffuse radiation above 35 MeV consists of two parts, one with a relatively hard galactic component and the other an isotropic, steep spectral component which extrapolates back well to the low energy diffuse radiation. The steepness of the diffuse isotropic component places significant constraints on possible theoretical models of this radiation.

  9. How to learn the usage of SAS software quickly%快速学会使用SAS软件的方法

    Institute of Scientific and Technical Information of China (English)

    郭春雪; 胡良平

    2016-01-01

    为了使读者能快速了解和学习到有关SAS软件的基础知识和用法,本文简明扼要地介绍了SAS软件的历史和结构,以及SAS软件有关的基础知识.包括SAS过程与SAS程序、运行SAS的两种常用方式、SAS程序结构、SAS语言、SAS用法,还有SASPAL软件.基于所介绍的内容,借助SASPAL软件,读者可以花较少的时间学会如何使用SAS软件解决约90%以上的生物医学和临床科研数据的统计分析问题.

  10. SHEDS-Multimedia Model Version 3 (a) Technical Manual; (b) User Guide; and (c) Executable File to Launch SAS Program and Install Model

    Science.gov (United States)

    Reliable models for assessing human exposures are important for understanding health risks from chemicals. The Stochastic Human Exposure and Dose Simulation model for multimedia, multi-route/pathway chemicals (SHEDS-Multimedia), developed by EPA’s Office of Research and Developm...

  11. 基于SAS软件实现随机抽样及应用%How to implement random sampling and application based on SAS software

    Institute of Scientific and Technical Information of China (English)

    胡完; 胡良平

    2016-01-01

    本文的目的是帮助读者方便快捷地运用SAS软件中的SURVEYSELECT过程实现随机抽样.首先,对SURVEYSELECT过程及SAS数据集Customers进行了简单介绍.接着,结合简单随机抽样、分层随机抽样和控制排序分层随机抽样,介绍了随机抽样的SAS实现方法.读者只需要修改本文中所呈现的SAS程序中的少量参数,就可很方便地使用SAS软件实现随机抽样任务.事实说明,尽管SAS软件非常难学难用,但借助现成的SAS程序,可以轻松自如地解决很多具体问题.

  12. Effect of ingested human antibodies induced by RTS, S/AS01 malaria vaccination in children on Plasmodium falciparum oocyst formation and sporogony in mosquitoes

    DEFF Research Database (Denmark)

    Miura, Kazutoyo; Jongert, Erik; Deng, Bingbing

    2014-01-01

    BACKGROUND: The circumsporozoite protein (CS protein) on the malaria parasites in mosquitoes plays an important role in sporogony in mosquitoes. The RTS,S/AS01 malaria vaccine candidate, which has shown significant efficacy against clinical malaria in a large Phase 3 trial, targets the Plasmodium...... falciparum CS protein, but the ability of serum from vaccinated individuals to inhibit sporogony in mosquitoes has not been evaluated. METHODS: Previously a double-blind, randomized trial of RTS,S/AS01 vaccine, as compared with rabies vaccine, in five- to 17-month old children in Tanzania was conducted...... of antibodies to inhibit P. falciparum oocyst formation and/or sporogony in the mosquito host was evaluated by a standard membrane-feeding assay. The test antibodies were fed on day 0 (at the same time as the gametocyte feed), or on days 3 or 6 (serial-feed experiments). The oocyst and sporozoite counts were...

  13. Plan de negocio para la creación de una empresa de servicios de mantenimiento a equipos de bombeo: Mantenimiento Integrado S.A.S.

    OpenAIRE

    2012-01-01

    En toda construcción comercial tal como edificios de apartamentos, edificios de oficinas, conjuntos residenciales, centros comerciales, hospitales, bibliotecas, colegios, universidades, es indispensable tener sistemas de bombeo para el abastecimiento de agua a los servicios generales, para el manejo de las aguas residuales y para la red de protección contra incendio. El sistema encargado de abastecer agua a los servicios generales es denominado “equipo de presión constante”,...

  14. Hidden gully erosion - detection and characterization of piping systems using geomorphological and geophysical methods (GPR, ERT)

    Science.gov (United States)

    Bernatek-Jakiel, Anita; Kondracka, Marta

    2016-04-01

    The significance of piping in gully formation and hillslope hydrology has been discussed for many years. However, piping as a subsurface erosion caused by water flowing through the soil is still considered as one of the most difficult erosion processes to study, because it occurs below the soil surface and traces of piping become visible on the surface only when a pipe roof collapses, or a pipe inlet or a pipe outlet has been located. Detection of pipes and their complex characterization is still a methodological challenge. Therefore, this study aims at a better detection and characterization of piping systems in a mountainous area under a temperate climate using geomorphological mapping and geophysical methods (ground penetrating radar and electrical resistivity tomography). The survey was carried out in the Bereźnica Wyżna catchment, in the Bieszczady Mts. (Eastern Carpathians, Poland), where pipes develop in Cambisols at a depth ranging from ca 0.70 to 1.00 m. The geomorphological mapping was carried out in the in the whole catchment (2.96 km2), whereas the geophysical survey was limited to two zones (zone A - ca 32 x 82 m, zone B - ca 58 x 115 m). In this study a standard RAMAC GPR system (Malå GeoScience) with shielded 500 MHz antenna was used. The electrical resistivity tomography (ERT) was performed using electrical imaging system LUND with Terrameter SAS 4000 produced by company ABEM. The ERT and GPR data were interpreted in the RES2DINV (Geotomo Software) and RadExplorer software (DECO Geophysical Ltd) respectively. In total, 3 longitudinal and 26 transverse GPR profiles and five ERTs were performed. The used geophysical techniques are shown to be successful in identifying pipes tested in the pilot catchment. Pipes identified by GPR and ERT were verified by the surface indicators (i.e. lowering of surface above pipes). The GPR and ERT applications suggest that piping systems density is much greater than could be detected from surface observation alone

  15. Geoelectrical Resistivity Imaging and Refraction Seismic Investigations at Sg.Udang, Melaka

    Directory of Open Access Journals (Sweden)

    Zeinab Asry

    2012-01-01

    Full Text Available Problem statement: A Reconnaissance geophysical survey of an area near Sg.Udang, Melaka was conducted using geoelectrical resistivity and seismic refraction methods. The main objective of this study is to determine the depth of bedrock in the study area. The resistivity imaging measurement employing Wenner electrode configuration was carried out using an ABEM SAS 1000 terrameter and electrode selector system ES464. Electrodes were arranged in a straight line with constant spacing and connected to a multicore cable. The refraction seismic was conducted using 24 channel ABEM Mark6 signal enhancement seismograph with 5 m geophone spacing. The resistivity layer is associated with the residual soil with thickness of about 0.5-3 m. The high velocity layer is an average depth of about 9.4 m. The intermediate velocity zone is associated with weathered schist with thickness of about 2.5 m. The low velocity zone is with thickness of about 6 m. The thickness of residual soil obtained by seismic refraction survey appears to agree very well with the borehole data. Resistivity and the seismic refraction data have been successfully used to determine the thickness of residual soil layer and depth of bedrock. Approach: In this survey, electrodes were arranged in a straight line with constant spacing and connected to a multicore cable. The refraction seismic was conducted using 24 channel ABEM Mark6 signal enhancement seismograph with 5 m geophone spacing. The seismic data have been interpreted using SeisOpt@2D which automatically produced 2-D seismic velocity sections of the subsurface. Results: The resistivity results showed that the subsurface layers are associated with variable resistivity (296-2600Ω. m. The resistivity layer is associated with the residual soil with thickness of about 0.5-3 m. The interpreted 2-D seismic sections showed three different velocity layers. The high velocity layer (1600-2000 m sec-1 is interpreted to be associated with bedrock

  16. Optimization of (R)-α-hydroxyphenylacetic acid fermentation medium by using response surface methodology%基于SAS9.1的芽孢杆菌发酵条件优化

    Institute of Scientific and Technical Information of China (English)

    陈秉梅; 侯志国; 李忠琴; 许小平

    2011-01-01

    为了提高菌株Bacillus sp.ULi-11生物合成(R)-α-羟基苯乙酸的产率,本文采用响应面法对其发酵条件进行优化.首先采用Plackett-Burman试验设计对影响产率的7个初始发酵条件进行评价,筛选出3个主要因素:温度、装液量和接种量.再用最陡爬坡方法逼近最大响应区域后,用Box-Behnken试验设计及响应面分析法进行回归分析,确定出最佳发酵条件分别为:温度35℃、装液量21.6 mL、接种量0.55%、种龄16 h、pH7.2、底物加入时间19 h、转速200 r/min.在此条件下,进行3批次的摇瓶实验,得到的(R)-α-羟基苯乙酸产率达81.71%,比优化前提高了12.7%.结果表明采用响应面试验设计优化方法有效提高了(R)-α-羟基苯乙酸的产率,为(R)-α-羟基苯乙酸的工业化应用提供了依据.%Response surface methodology was applied to optimize the fermentation conditions to improve the yield of (R)-a-hydroxyphenylacetic acid by Bacillus sp. ULi-11. By the initial screening, Plackett-Burman design was used for the evaluation of seven factors, and three factors. Temperature, fermentation volume and inoculating amount were found to be the important factors affecting (R)-a-hydroxyphenylacetic acid production significantly. Path of steepest ascent was undertaken to approach the optimal region of the fermentation conditions subsequently. Finally, the conditions of those three main factors were further optimized by using Box-Behnken and response surface methodology. By solving the quadratic regression model equation, the optimal fermentation conditions of Bacillus sp.ULi-11 were determined as: fermentation temperature 35'C, liquid volume 21.6 ml, inoculating amount 0.55%, seed age 16 h, pH 7.2, addtime of PGA 19 h and rotate speed 200 rpm. The yield of (R)-a-hydroxyphenylacetic acid (81.71%) was promoted by 12.7%, compared to which obtained from initial fermentation conditions. It can be concluded that using response surface methodology to find the optimal fermentation conditions for (R)-a-hydroxyphenylacetic acid is available, and the increase of (R)-a-hydroxyphenylacetic acid yield is remarkable. It affords an experimental basis for the industrial application of (R)-a-hydroxyphenylacetic.

  17. Análisis de viabilidad de la creación de una unidad estratégica de negocio en la organización FERKATÍO S.A.S.

    OpenAIRE

    Urrego Álvarez, Mauricio

    2016-01-01

    El presente trabajo de grado analiza la viabilidad de crear una unidad estratégica de negocios dedicada a atender el segmento de mercado compuesto por los cerrajeros en Urabá de manera independiente y especializada con su respectivo portafolio de productos -- Dicho portafolio comprende no solo los mercados que se atienden actualmente sino también otros nuevos en los que se incursionaría, permitiendo así aumentar la oferta para este segmento sobre la base de algunas limitaciones que se han ...

  18. Three-dimensional Multi-UAV Cooperative Path Planning Based on Improved SAS Algorithm%基于SAS算法的三维多UAV协同航迹规划方法

    Institute of Scientific and Technical Information of China (English)

    王奎民

    2013-01-01

    在实际应用中航迹规划着重考虑的是规划出的航迹应具有良好的可靠性能,针对多UAV协同航迹规划有多个约束条件且环境复杂、规划耗时长等问题,使用智能算法解决多UAV协同航迹规划问题无法确保规划航迹的可靠性能.因此,提出了一种启发式SAS算法,用以解决此问题.仿真结果证明,使用该算法规划出的航迹具有较高的可靠性.

  19. Plan de internacionalización de AMGEN biotecnológica SAS selección país objetivo para la expansión en Latinoamérica [recurso electrónico

    OpenAIRE

    Saldarriaga Morales , Jose Fernando

    2014-01-01

    En los últimos 10 años, el mercado farmacéutico internacional se ha caracterizado por las fusiones y adquisiciones entre las grandes casas farmacéuticas. Este ambiente competitivo ha hecho que los laboratorios farmacéuticos que no han experimentado este tipo de fusiones o adquisiciones, amplíen su presencia en los diferentes mercados emergentes, buscando desarrollar sus negocios y obtener crecimientos en ventas superiores a los mercados maduros de Estados Unidos y Europa. El entorno compet...

  20. 睡眠呼吸暂停综合征对睡眠结构和脑功能的影响%Effect of Sleep Apnea Syndrome (SAS) of Different Severity on Sleep Architecture and Cerebral Function of Patients

    Institute of Scientific and Technical Information of China (English)

    毛毅敏; 刘红梅; 孙瑜霞

    2003-01-01

    目的探讨不同程度睡眠呼吸暂停综合症对患者睡眠结构及脑功能的影响.方法应用多导睡眠图对130例打鼾患者进行监测,同时分析其临床表现.结果轻度睡眠呼吸暂停综合症患者与中、重度患者睡眠结构比较有显著差异,中度与重度患者比较仅Ⅲ+Ⅳ期睡眠/睡眠时间有统计学意义.结论睡眠呼吸暂停综合症患者随病情的加重,反复睡眠中断可能是造成患者脑功能损害的重要原因.