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Sample records for sars virus n-protein

  1. Transient oligomerization of the SARS-CoV N protein--implication for virus ribonucleoprotein packaging.

    Science.gov (United States)

    Chang, Chung-ke; Chen, Chia-Min Michael; Chiang, Ming-hui; Hsu, Yen-lan; Huang, Tai-huang

    2013-01-01

    The nucleocapsid (N) phosphoprotein of the severe acute respiratory syndrome coronavirus (SARS-CoV) packages the viral genome into a helical ribonucleocapsid and plays a fundamental role during viral self-assembly. The N protein consists of two structural domains interspersed between intrinsically disordered regions and dimerizes through the C-terminal structural domain (CTD). A key activity of the protein is the ability to oligomerize during capsid formation by utilizing the dimer as a building block, but the structural and mechanistic bases of this activity are not well understood. By disulfide trapping technique we measured the amount of transient oligomers of N protein mutants with strategically located cysteine residues and showed that CTD acts as a primary transient oligomerization domain in solution. The data is consistent with the helical oligomer packing model of N protein observed in crystal. A systematic study of the oligomerization behavior revealed that altering the intermolecular electrostatic repulsion through changes in solution salt concentration or phosphorylation-mimicking mutations affects oligomerization propensity. We propose a biophysical mechanism where electrostatic repulsion acts as a switch to regulate N protein oligomerization.

  2. Transient oligomerization of the SARS-CoV N protein--implication for virus ribonucleoprotein packaging.

    Directory of Open Access Journals (Sweden)

    Chung-ke Chang

    Full Text Available The nucleocapsid (N phosphoprotein of the severe acute respiratory syndrome coronavirus (SARS-CoV packages the viral genome into a helical ribonucleocapsid and plays a fundamental role during viral self-assembly. The N protein consists of two structural domains interspersed between intrinsically disordered regions and dimerizes through the C-terminal structural domain (CTD. A key activity of the protein is the ability to oligomerize during capsid formation by utilizing the dimer as a building block, but the structural and mechanistic bases of this activity are not well understood. By disulfide trapping technique we measured the amount of transient oligomers of N protein mutants with strategically located cysteine residues and showed that CTD acts as a primary transient oligomerization domain in solution. The data is consistent with the helical oligomer packing model of N protein observed in crystal. A systematic study of the oligomerization behavior revealed that altering the intermolecular electrostatic repulsion through changes in solution salt concentration or phosphorylation-mimicking mutations affects oligomerization propensity. We propose a biophysical mechanism where electrostatic repulsion acts as a switch to regulate N protein oligomerization.

  3. SARS virus

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. SARS virus. Novel corona virus emerges in the new millenia. Genome sequences invariant- global isolates do not show differences of consequence.Protein spike similar. HE gene absent. 2787 nucleotides. Largest genome. Jumps species by genetic deletion.

  4. How infectious is SARS virus

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. How infectious is SARS virus. Influenza: 1 patient infects ten people. SARS: 1 patient infects 2-4 people. Incubation period 10 days. Are there `silent´ cases ? Is quarantine enough ? How will it behave if and when it returns ?

  5. SARSvirus jumps species

    Indian Academy of Sciences (India)

    SARSvirus jumps species. Coronavirus reshuffles genes; Rotteir et al, Rotterdam showed the virus to jump from cats to mouse cells after single gene mutation ? Human disease due to virus jumping from wild or domestic animals; Present favourite animal - the cat; - edible or domestic.

  6. Ribonucleocapsid Formation of SARS-COV Through Molecular Action of the N-Terminal Domain of N Protein

    Energy Technology Data Exchange (ETDEWEB)

    Saikatendu, K.S.; Joseph, J.S.; Subramanian, V.; Neuman, B.W.; Buchmeier, M.J.; Stevens, R.C.; Kuhn, P.; /Scripps Res. Inst.

    2007-07-12

    Conserved amongst all coronaviruses are four structural proteins, the matrix (M), small envelope (E) and spike (S) that are embedded in the viral membrane and the nucleocapsid phosphoprotein (N), which exists in a ribonucleoprotein complex in their lumen. The N terminal domain of coronaviral N proteins (N-NTD) provides a scaffold for RNA binding while the C-terminal domain (N-CTD) mainly acts as oligomerization modules during assembly. The C-terminus of N protein anchors it to the viral membrane by associating with M protein. We characterized the structures of N-NTD from severe acute respiratory syndrome coronavirus (SARS-CoV) in two crystal forms, at 1.17A (monoclinic) and 1.85 A (cubic) respectively, solved by molecular replacement using the homologous avian infectious bronchitis virus (IBV) structure. Flexible loops in the solution structure of SARS-CoV N-NTD are now shown to be well ordered around the beta-sheet core. The functionally important positively charged beta-hairpin protrudes out of the core and is oriented similar to that in the IBV N-NTD and is involved in crystal packing in the monoclinic form. In the cubic form, the monomers form trimeric units that stack in a helical array. Comparison of crystal packing of SARS-CoV and IBV N-NTDs suggest a common mode of RNA recognition, but probably associate differently in vivo during the formation of the ribonucleoprotein complex. Electrostatic potential distribution on the surface of homology models of related coronaviral N-NTDs hints that they employ different modes of both RNA recognition as well as oligomeric assembly, perhaps explaining why their nucleocapsids have different morphologies.

  7. Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus.

    Directory of Open Access Journals (Sweden)

    Chien-Te Tseng

    Full Text Available Severe acute respiratory syndrome (SARS emerged in China in 2002 and spread to other countries before brought under control. Because of a concern for reemergence or a deliberate release of the SARS coronavirus, vaccine development was initiated. Evaluations of an inactivated whole virus vaccine in ferrets and nonhuman primates and a virus-like-particle vaccine in mice induced protection against infection but challenged animals exhibited an immunopathologic-type lung disease.Four candidate vaccines for humans with or without alum adjuvant were evaluated in a mouse model of SARS, a VLP vaccine, the vaccine given to ferrets and NHP, another whole virus vaccine and an rDNA-produced S protein. Balb/c or C57BL/6 mice were vaccinated i.m. on day 0 and 28 and sacrificed for serum antibody measurements or challenged with live virus on day 56. On day 58, challenged mice were sacrificed and lungs obtained for virus and histopathology.All vaccines induced serum neutralizing antibody with increasing dosages and/or alum significantly increasing responses. Significant reductions of SARS-CoV two days after challenge was seen for all vaccines and prior live SARS-CoV. All mice exhibited histopathologic changes in lungs two days after challenge including all animals vaccinated (Balb/C and C57BL/6 or given live virus, influenza vaccine, or PBS suggesting infection occurred in all. Histopathology seen in animals given one of the SARS-CoV vaccines was uniformly a Th2-type immunopathology with prominent eosinophil infiltration, confirmed with special eosinophil stains. The pathologic changes seen in all control groups lacked the eosinophil prominence.These SARS-CoV vaccines all induced antibody and protection against infection with SARS-CoV. However, challenge of mice given any of the vaccines led to occurrence of Th2-type immunopathology suggesting hypersensitivity to SARS-CoV components was induced. Caution in proceeding to application of a SARS-CoV vaccine in

  8. Reverse genetics of SARS-related coronavirus using vaccinia virus-based recombination.

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    Sjoerd H E van den Worm

    Full Text Available Severe acute respiratory syndrome (SARS is a zoonotic disease caused by SARS-related coronavirus (SARS-CoV that emerged in 2002 to become a global health concern. Although the original outbreak was controlled by classical public health measures, there is a real risk that another SARS-CoV could re-emerge from its natural reservoir, either in its original form or as a more virulent or pathogenic strain; in which case, the virus would be difficult to control in the absence of any effective antiviral drugs or vaccines. Using the well-studied SARS-CoV isolate HKU-39849, we developed a vaccinia virus-based SARS-CoV reverse genetic system that is both robust and biosafe. The SARS-CoV genome was cloned in separate vaccinia virus vectors, (vSARS-CoV-5prime and vSARS-CoV-3prime as two cDNAs that were subsequently ligated to create a genome-length SARS-CoV cDNA template for in vitro transcription of SARS-CoV infectious RNA transcripts. Transfection of the RNA transcripts into permissive cells led to the recovery of infectious virus (recSARS-CoV. Characterization of the plaques produced by recSARS-CoV showed that they were similar in size to the parental SARS-CoV isolate HKU-39849 but smaller than the SARS-CoV isolate Frankfurt-1. Comparative analysis of replication kinetics showed that the kinetics of recSARS-CoV replication are similar to those of SARS-CoV Frankfurt-1, although the titers of virus released into the culture supernatant are approximately 10-fold less. The reverse genetic system was finally used to generate a recSARS-CoV reporter virus expressing Renilla luciferase in order to facilitate the analysis of SARS-CoV gene expression in human dendritic cells (hDCs. In parallel, a Renilla luciferase gene was also inserted into the genome of human coronavirus 229E (HCoV-229E. Using this approach, we demonstrate that, in contrast to HCoV-229E, SARS-CoV is not able to mediate efficient heterologous gene expression in hDCs.

  9. Immune responses against SARS-coronavirus nucleocapsid protein induced by DNA vaccine

    International Nuclear Information System (INIS)

    Zhao Ping; Cao Jie; Zhao Lanjuan; Qin Zhaolin; Ke Jinshan; Pan Wei; Ren Hao; Yu Jianguo; Qi Zhongtian

    2005-01-01

    The nucleocapsid (N) protein of SARS-coronavirus (SARS-CoV) is the key protein for the formation of the helical nucleocapsid during virion assembly. This protein is believed to be more conserved than other proteins of the virus, such as spike and membrane glycoprotein. In this study, the N protein of SARS-CoV was expressed in Escherichia coli DH5α and identified with pooled sera from patients in the convalescence phase of SARS. A plasmid pCI-N, encoding the full-length N gene of SARS-CoV, was constructed. Expression of the N protein was observed in COS1 cells following transfection with pCI-N. The immune responses induced by intramuscular immunization with pCI-N were evaluated in a murine model. Serum anti-N immunoglobulins and splenocytes proliferative responses against N protein were observed in immunized BALB/c mice. The major immunoglobulin G subclass recognizing N protein was immunoglobulin G2a, and stimulated splenocytes secreted high levels of gamma interferon and IL-2 in response to N protein. More importantly, the immunized mice produced strong delayed-type hypersensitivity (DTH) and CD8 + CTL responses to N protein. The study shows that N protein of SARS-CoV not only is an important B cell immunogen, but also can elicit broad-based cellular immune responses. The results indicate that the N protein may be of potential value in vaccine development for specific prophylaxis and treatment against SARS

  10. Identifying SARS-CoV membrane protein amino acid residues linked to virus-like particle assembly.

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    Ying-Tzu Tseng

    Full Text Available Severe acute respiratory syndrome coronavirus (SARS-CoV membrane (M proteins are capable of self-assembly and release in the form of membrane-enveloped vesicles, and of forming virus-like particles (VLPs when coexpressed with SARS-CoV nucleocapsid (N protein. According to previous deletion analyses, M self-assembly involves multiple M sequence regions. To identify important M amino acid residues for VLP assembly, we coexpressed N with multiple M mutants containing substitution mutations at the amino-terminal ectodomain, carboxyl-terminal endodomain, or transmembrane segments. Our results indicate that a dileucine motif in the endodomain tail (218LL219 is required for efficient N packaging into VLPs. Results from cross-linking VLP analyses suggest that the cysteine residues 63, 85 and 158 are not in close proximity to the M dimer interface. We noted a significant reduction in M secretion due to serine replacement for C158, but not for C63 or C85. Further analysis suggests that C158 is involved in M-N interaction. In addition to mutations of the highly conserved 107-SWWSFNPE-114 motif, substitutions at codons W19, W57, P58, W91, Y94 or F95 all resulted in significantly reduced VLP yields, largely due to defective M secretion. VLP production was not significantly affected by a tryptophan replacement of Y94 or F95 or a phenylalanine replacement of W19, W57 or W91. Combined, these results indicate the involvement of specific M amino acids during SARS-CoV virus assembly, and suggest that aromatic residue retention at specific positions is critical for M function in terms of directing virus assembly.

  11. How change of public transportation usage reveals fear of the SARS virus in a city.

    Directory of Open Access Journals (Sweden)

    Kuo-Ying Wang

    Full Text Available The outbreaks of the severe acute respiratory syndrome (SARS epidemic in 2003 resulted in unprecedented impacts on people's daily life. One of the most significant impacts to people is the fear of contacting the SARS virus while engaging daily routine activity. Here we use data from daily underground ridership in Taipei City and daily reported new SARS cases in Taiwan to model the dynamics of the public fear of the SARS virus during the wax and wane of the SARS period. We found that for each reported new SARS case there is an immediate loss of about 1200 underground ridership (the fresh fear. These daily loss rates dissipate to the following days with an e-folding time of about 28 days, reflecting the public perception on the risk of contacting SARS virus when traveling with the underground system (the residual fear. About 50% of daily ridership was lost during the peak of the 2003 SARS period, compared with the loss of 80% daily ridership during the closure of the underground system after Typhoon Nari, the loss of 50-70% ridership due to the closure of the governmental offices and schools during typhoon periods, and the loss of 60% daily ridership during Chinese New Year holidays.

  12. How change of public transportation usage reveals fear of the SARS virus in a city.

    Science.gov (United States)

    Wang, Kuo-Ying

    2014-01-01

    The outbreaks of the severe acute respiratory syndrome (SARS) epidemic in 2003 resulted in unprecedented impacts on people's daily life. One of the most significant impacts to people is the fear of contacting the SARS virus while engaging daily routine activity. Here we use data from daily underground ridership in Taipei City and daily reported new SARS cases in Taiwan to model the dynamics of the public fear of the SARS virus during the wax and wane of the SARS period. We found that for each reported new SARS case there is an immediate loss of about 1200 underground ridership (the fresh fear). These daily loss rates dissipate to the following days with an e-folding time of about 28 days, reflecting the public perception on the risk of contacting SARS virus when traveling with the underground system (the residual fear). About 50% of daily ridership was lost during the peak of the 2003 SARS period, compared with the loss of 80% daily ridership during the closure of the underground system after Typhoon Nari, the loss of 50-70% ridership due to the closure of the governmental offices and schools during typhoon periods, and the loss of 60% daily ridership during Chinese New Year holidays.

  13. A double-inactivated whole virus candidate SARS coronavirus vaccine stimulates neutralising and protective antibody responses.

    Science.gov (United States)

    Spruth, Martin; Kistner, Otfried; Savidis-Dacho, Helga; Hitter, Elisabeth; Crowe, Brian; Gerencer, Marijan; Brühl, Peter; Grillberger, Leopold; Reiter, Manfred; Tauer, Christa; Mundt, Wolfgang; Barrett, P Noel

    2006-01-30

    A double-inactivated, candidate whole virus vaccine against severe acute respiratory syndrome associated coronavirus (SARS-CoV) was developed and manufactured at large scale using fermenter cultures of serum protein free Vero cells. A two step inactivation procedure involving sequential formaldehyde and U.V. inactivation was utilised in order to ensure an extremely high safety margin with respect to residual infectivity. The immunogenicity of this double-inactivated vaccine was characterised in the mouse model. Mice that were immunised twice with the candidate SARS-CoV vaccine developed high antibody titres against the SARS-CoV spike protein and high levels of neutralising antibodies. The use of the adjuvant Al(OH)3 had only a minor effect on the immunogenicity of the vaccine. In addition, cell mediated immunity as measured by interferon-gamma and interleukin-4 stimulation, was elicited by vaccination. Moreover, the vaccine confers protective immunity as demonstrated by prevention of SARS-CoV replication in the respiratory tract of mice after intranasal challenge with SARS-CoV. Protection of mice was correlated to antibody titre against the SARS-CoV S protein and neutralising antibody titre.

  14. Coronavirus 3CL(pro) proteinase cleavage sites: Possible relevance to SARS virus pathology

    DEFF Research Database (Denmark)

    Kiemer, Lars; Lund, Ole; Brunak, Søren

    2004-01-01

    . Prompted by this, we set out to analyse and predict cleavage by the coronavirus main proteinase using computational methods. Results: We retrieved sequence data on seven fully sequenced coronaviruses and identified the main 3CL proteinase cleavage sites in polyproteins using alignments. A neural network...... which might be important to elucidate coronavirus pathology. Furthermore, the method might assist in design of proteinase inhibitors for treatment of SARS and possible future diseases caused by coronaviruses.......Background: Despite the passing of more than a year since the first outbreak of Severe Acute Respiratory Syndrome (SARS), efficient counter-measures are still few and many believe that reappearance of SARS, or a similar disease caused by a coronavirus, is not unlikely. For other virus families like...

  15. Reference gene selection for quantitative real-time PCR analysis in virus infected cells: SARS corona virus, Yellow fever virus, Human Herpesvirus-6, Camelpox virus and Cytomegalovirus infections

    Directory of Open Access Journals (Sweden)

    Müller Marcel A

    2005-02-01

    Full Text Available Abstract Ten potential reference genes were compared for their use in experiments investigating cellular mRNA expression of virus infected cells. Human cell lines were infected with Cytomegalovirus, Human Herpesvirus-6, Camelpox virus, SARS coronavirus or Yellow fever virus. The expression levels of these genes and the viral replication were determined by real-time PCR. Genes were ranked by the BestKeeper tool, the GeNorm tool and by criteria we reported previously. Ranking lists of the genes tested were tool dependent. However, over all, β-actin is an unsuitable as reference gene, whereas TATA-Box binding protein and peptidyl-prolyl-isomerase A are stable reference genes for expression studies in virus infected cells.

  16. Generation of human antibody fragments recognizing distinct epitopes of the nucleocapsid (N SARS-CoV protein using a phage display approach

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    Grasso Felicia

    2005-09-01

    Full Text Available Abstract Background Severe acute respiratory syndrome (SARS-CoV is a newly emerging virus that causes SARS with high mortality rate in infected people. Successful control of the global SARS epidemic will require rapid and sensitive diagnostic tests to monitor its spread, as well as, the development of vaccines and new antiviral compounds including neutralizing antibodies that effectively prevent or treat this disease. Methods The human synthetic single-chain fragment variable (scFv ETH-2 phage antibody library was used for the isolation of scFvs against the nucleocapsid (N protein of SARS-CoV using a bio panning-based strategy. The selected scFvs were characterized under genetics-molecular aspects and for SARS-CoV N protein detection in ELISA, western blotting and immunocytochemistry. Results Human scFv antibodies to N protein of SARS-CoV can be easily isolated by selecting the ETH-2 phage library on immunotubes coated with antigen. These in vitro selected human scFvs specifically recognize in ELISA and western blotting studies distinct epitopes in N protein domains and detect in immunohistochemistry investigations SARS-CoV particles in infected Vero cells. Conclusion The human scFv antibodies isolated and described in this study represent useful reagents for rapid detection of N SARS-CoV protein and SARS virus particles in infected target cells.

  17. Generation of human antibody fragments recognizing distinct epitopes of the nucleocapsid (N) SARS-CoV protein using a phage display approach

    Science.gov (United States)

    Flego, Michela; Di Bonito, Paola; Ascione, Alessandro; Zamboni, Silvia; Carattoli, Alessandra; Grasso, Felicia; Cassone, Antonio; Cianfriglia, Maurizio

    2005-01-01

    Background Severe acute respiratory syndrome (SARS)-CoV is a newly emerging virus that causes SARS with high mortality rate in infected people. Successful control of the global SARS epidemic will require rapid and sensitive diagnostic tests to monitor its spread, as well as, the development of vaccines and new antiviral compounds including neutralizing antibodies that effectively prevent or treat this disease. Methods The human synthetic single-chain fragment variable (scFv) ETH-2 phage antibody library was used for the isolation of scFvs against the nucleocapsid (N) protein of SARS-CoV using a bio panning-based strategy. The selected scFvs were characterized under genetics-molecular aspects and for SARS-CoV N protein detection in ELISA, western blotting and immunocytochemistry. Results Human scFv antibodies to N protein of SARS-CoV can be easily isolated by selecting the ETH-2 phage library on immunotubes coated with antigen. These in vitro selected human scFvs specifically recognize in ELISA and western blotting studies distinct epitopes in N protein domains and detect in immunohistochemistry investigations SARS-CoV particles in infected Vero cells. Conclusion The human scFv antibodies isolated and described in this study represent useful reagents for rapid detection of N SARS-CoV protein and SARS virus particles in infected target cells. PMID:16171519

  18. Potent Human Monoclonal Antibodies against SARS CoV, Nipah and Hendra Viruses

    Science.gov (United States)

    Prabakaran, Ponraj; Zhongyu, Zhu; Xiao, Xiaodong; Biragyn, Arya; Dimitrov, Antony S.; Broder, Christopher C.; Dimitrov, Dimiter S.

    2009-01-01

    Polyclonal antibodies have a century-old history of being effective against some viruses; recently, monoclonal antibodies (mAbs) have also shown success. The humanized mAb Synagis (palivizumab) remains still the only mAb against respiratory syncytial virus (RSV) infections approved by the U.S. Food and Drug Administration (FDA). Recently, several potent human monoclonal antibodies (hmAbs) targeting the Severe Acute Respiratory Syndrome-Associated coronavirus (SARS CoV) S glycoproteins were developed quickly after the virus was identified in 2003. Among these antibodies, m396 and S230.15 exhibit exceptional potency and cross-reactivity as they neutralize isolates from the first and second outbreaks and from palm civets both in vitroand in mice. Similarly, the first fully hmAbs against two other paramyxoviruses, Hendra virus (HeV) and Nipah virus (NiV), which can cause up to 75% mortality, were recently developed; one of them, m102.4, shows exceptional cross-reactive potency against both NiV and HeV. Three-dimensional molecular structures of envelope glycoproteins from these viruses in complexes with antibodies and/or receptors were recently determined. Structural analyses along with other experiments have provided insights into the molecular mechanisms of receptor recognition and antibody neutralization, and suggested that these antibodies alone or in combination could successfully fight the viruses’ heterogeneity and mutability which is a major problem in the development of effective therapeutic agents against viruses, including therapeutic antibodies. PMID:19216624

  19. Coordinate induction of IFN-α and -γ by SARS-CoV also in the absence of virus replication

    International Nuclear Information System (INIS)

    Castilletti, Concetta; Bordi, Licia; Lalle, Eleonora; Rozera, Gabriella; Poccia, Fabrizio; Agrati, Chiara; Abbate, Isabella; Capobianchi, Maria R.

    2005-01-01

    Background:: Severe acute respiratory syndrome (SARS) is an emerging infection caused by a novel coronavirus known as SARS-CoV, characterized by an over-exuberant immune response with lung lymphomononuclear cells infiltration and proliferation that may account for tissue damage more than the direct effect of viral replication. This study is aimed at investigating the capability of SARS-CoV to activate IFN-α and -γ expression in lymphomonocytes (PBMC) from healthy donors, evaluating whether viral replication is necessary for this activation. Results:: SARS-CoV virus is able to induce both IFN-α and -γ mRNA accumulation and protein release in a dose-dependent manner, MOI 10 being the most effective. The time course curve indicated that IFN-α mRNA induction peaked at 24 h.p.i,. whereas IFN-γ mRNA was still increasing at 48 h.p.i. Released IFN (both types) reached a plateau after 24-48 h.p.i. and remained rather stable over a 5-day period. A transient peak of negative strand viral RNA was detected after 1-2 days of infection, but neither infectious virus progeny yield nor newly produced viral genomic RNA could be evidenced in infected cultures, even after prolonged observation time (up to 13 days). Cocultivation of PBMC with fixed SARS-CoV-infected Vero cells was even more efficient than exposure to live virus in eliciting IFN-α and -γ induction. A combination of IFN-α and -γ strongly inhibited SARS-CoV replication in Vero cells, while the single cytokines were much less effective. Conclusions:: This study provides evidence that SARS-CoV is able to induce in normal PBMC a coordinate induction of IFN-α and -γ gene expression. Virus replication is not necessary for IFN induction since efficient IFN expression could be obtained also by the cocultivation of normal PBMC with fixed SARS-CoV-infected cells. Concomitant activation of IFN-α and -γ gene expression by SARS-CoV in vivo may be relevant for the pathogenesis of the disease, both for the possible

  20. Challenges and Strategies of Laboratory Diagnosis for Newly Emerging Influenza Viruses in Taiwan: A Decade after SARS

    Directory of Open Access Journals (Sweden)

    Jih-Hui Lin

    2015-01-01

    Full Text Available Since the first case of severe acute respiratory syndrome (SARS in Taiwan was identified in March 2003, viral respiratory infections, in particular the influenza virus, have become a national public health concern. Taiwan would face a serious threat of public health problems if another SARS epidemic overlapped with a flu outbreak. After SARS, the Taiwan Centers for Disease Control accelerated and strengthened domestic research on influenza and expanded the exchange of information with international counterparts. The capacity of influenza A to cross species barriers presents a potential threat to human health. Given the mutations of avian flu viruses such as H7N9, H6N1, and H10N8, all countries, including Taiwan, must equip themselves to face a possible epidemic or pandemic. Such preparedness requires global collaboration.

  1. A Network Integration Approach to Predict Conserved Regulators Related to Pathogenicity of Influenza and SARS-CoV Respiratory Viruses

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, Hugh D.; Eisfeld, Amie J.; Sims, Amy; McDermott, Jason E.; Matzke, Melissa M.; Webb-Robertson, Bobbie-Jo M.; Tilton, Susan C.; Tchitchek, Nicholas; Josset, Laurence; Li, Chengjun; Ellis, Amy L.; Chang, Jean H.; Heegel, Robert A.; Luna, Maria L.; Schepmoes, Athena A.; Shukla, Anil K.; Metz, Thomas O.; Neumann, Gabriele; Benecke, Arndt; Smith, Richard D.; Baric, Ralph; Kawaoka, Yoshihiro; Katze, Michael G.; Waters, Katrina M.

    2013-07-25

    Respiratory infections stemming from influenza viruses and the Severe Acute Respiratory Syndrome corona virus (SARS-CoV) represent a serious public health threat as emerging pandemics. Despite efforts to identify the critical interactions of these viruses with host machinery, the key regulatory events that lead to disease pathology remain poorly targeted with therapeutics. Here we implement an integrated network interrogation approach, in which proteome and transcriptome datasets from infection of both viruses in human lung epithelial cells are utilized to predict regulatory genes involved in the host response. We take advantage of a novel “crowd-based” approach to identify and combine ranking metrics that isolate genes/proteins likely related to the pathogenicity of SARS-CoV and influenza virus. Subsequently, a multivariate regression model is used to compare predicted lung epithelial regulatory influences with data derived from other respiratory virus infection models. We predicted a small set of regulatory factors with conserved behavior for consideration as important components of viral pathogenesis that might also serve as therapeutic targets for intervention. Our results demonstrate the utility of integrating diverse ‘omic datasets to predict and prioritize regulatory features conserved across multiple pathogen infection models.

  2. Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing

    Science.gov (United States)

    Eckerle, Lance D.; Becker, Michelle M.; Halpin, Rebecca A.; Li, Kelvin; Venter, Eli; Lu, Xiaotao; Scherbakova, Sana; Graham, Rachel L.; Baric, Ralph S.; Stockwell, Timothy B.; Spiro, David J.; Denison, Mark R.

    2010-01-01

    Most RNA viruses lack the mechanisms to recognize and correct mutations that arise during genome replication, resulting in quasispecies diversity that is required for pathogenesis and adaptation. However, it is not known how viruses encoding large viral RNA genomes such as the Coronaviridae (26 to 32 kb) balance the requirements for genome stability and quasispecies diversity. Further, the limits of replication infidelity during replication of large RNA genomes and how decreased fidelity impacts virus fitness over time are not known. Our previous work demonstrated that genetic inactivation of the coronavirus exoribonuclease (ExoN) in nonstructural protein 14 (nsp14) of murine hepatitis virus results in a 15-fold decrease in replication fidelity. However, it is not known whether nsp14-ExoN is required for replication fidelity of all coronaviruses, nor the impact of decreased fidelity on genome diversity and fitness during replication and passage. We report here the engineering and recovery of nsp14-ExoN mutant viruses of severe acute respiratory syndrome coronavirus (SARS-CoV) that have stable growth defects and demonstrate a 21-fold increase in mutation frequency during replication in culture. Analysis of complete genome sequences from SARS-ExoN mutant viral clones revealed unique mutation sets in every genome examined from the same round of replication and a total of 100 unique mutations across the genome. Using novel bioinformatic tools and deep sequencing across the full-length genome following 10 population passages in vitro, we demonstrate retention of ExoN mutations and continued increased diversity and mutational load compared to wild-type SARS-CoV. The results define a novel genetic and bioinformatics model for introduction and identification of multi-allelic mutations in replication competent viruses that will be powerful tools for testing the effects of decreased fidelity and increased quasispecies diversity on viral replication, pathogenesis, and

  3. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

    Energy Technology Data Exchange (ETDEWEB)

    Ratia, Kiira; Pegan, Scott; Takayama, Jun; Sleeman, Katrina; Coughlin, Melissa; Baliji, Surendranath; Chaudhuri, Rima; Fu, Wentao; Prabhakar, Bellur S.; Johnson, Michael E.; Baker, Susan C.; Ghosh, Arun K.; Mesecar, Andrew D. (Loyola); (Purdue); (UIC)

    2008-10-27

    We report the discovery and optimization of a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). This unique protease is not only responsible for processing the viral polyprotein into its functional units but is also capable of cleaving ubiquitin and ISG15 conjugates and plays a significant role in helping SARS-CoV evade the human immune system. We screened a structurally diverse library of 50,080 compounds for inhibitors of PLpro and discovered a noncovalent lead inhibitor with an IC{sub 50} value of 20 {mu}M, which was improved to 600 nM via synthetic optimization. The resulting compound, GRL0617, inhibited SARS-CoV viral replication in Vero E6 cells with an EC{sub 50} of 15 {mu}M and had no associated cytotoxicity. The X-ray structure of PLpro in complex with GRL0617 indicates that the compound has a unique mode of inhibition whereby it binds within the S4-S3 subsites of the enzyme and induces a loop closure that shuts down catalysis at the active site. These findings provide proof-of-principle that PLpro is a viable target for development of antivirals directed against SARS-CoV, and that potent noncovalent cysteine protease inhibitors can be developed with specificity directed toward pathogenic deubiquitinating enzymes without inhibiting host DUBs.

  4. SARS – Koch´Postulates proved.

    Indian Academy of Sciences (India)

    SARS – Koch´Postulates proved. Novel coronavirus identified from fluids of patients. Virus cultured in Vero cell line. Sera of patients have antibodies to virus. Cultured virus produces disease in Macaque monkeys. -produces specific immune response; -isolated virus is SARS CoV; -pathology similar to human.

  5. Antigen Production in Plant to Tackle Infectious Diseases Flare Up: the Case of SARS

    Directory of Open Access Journals (Sweden)

    Olivia C eDemurtas

    2016-02-01

    Full Text Available Severe Acute Respiratory Syndrome (SARS is a dangerous infection with pandemic potential. It emerged in 2002 and its aetiological agent, the SARS Coronavirus (SARS-CoV, crossed the species barrier to infect humans, showing high morbidity and mortality rates. No vaccines are currently licensed for SARS-CoV and important efforts have been performed during the first outbreak to develop diagnostic tools. Here we demonstrate the transient expression in Nicotiana benthamiana of two important antigenic determinants of the SARS-CoV, the nucleocapsid protein (N and the membrane protein (M using a virus-derived vector or agro-infiltration, respectively. For the M protein, this is the first description of production in plants, while for plant-derived N protein we demonstrate that it is recognized by sera of patients from the SARS outbreak in Hong Kong in 2003. The availability of recombinant N and M proteins from plants opens the way to further evaluation of their potential utility for the development of diagnostic and protection/therapy tools to be quickly manufactured, at low cost and with minimal risk, to face potential new highly infectious SARS-CoV outbreaks.

  6. Bats and SARS

    Centers for Disease Control (CDC) Podcasts

    2006-11-08

    Bats are a natural reservoir for emerging viruses, among them henipaviruses and rabies virus variants. Dr. Nina Marano, Chief, Geographic Medicine and Health Promotion Branch, Division of Global Migration and Quarantine, CDC, explains connection between horseshoe bats and SARS coronavirus transmission.  Created: 11/8/2006 by Emerging Infectious Diseases.   Date Released: 11/17/2006.

  7. Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses

    DEFF Research Database (Denmark)

    Schandock, Franziska; Riber, Camilla Frich; Röcker, Annika

    2017-01-01

    . This work performs selection of synthetic polymers as novel broadly active agents and demonstrates activity of these polymers against Zika, Ebola, Lassa, Lyssa, Rabies, Marburg, Ebola, influenza, herpes simplex, and human immunodeficiency viruses. Results presented herein offer structure...

  8. Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)*

    Science.gov (United States)

    Zhou, Nan; Pan, Ting; Zhang, Junsong; Li, Qianwen; Zhang, Xue; Bai, Chuan; Huang, Feng; Peng, Tao; Zhang, Jianhua; Liu, Chao; Tao, Liang; Zhang, Hui

    2016-01-01

    Ebola virus infection can cause severe hemorrhagic fever with a high mortality in humans. The outbreaks of Ebola viruses in 2014 represented the most serious Ebola epidemics in history and greatly threatened public health worldwide. The development of additional effective anti-Ebola therapeutic agents is therefore quite urgent. In this study, via high throughput screening of Food and Drug Administration-approved drugs, we identified that teicoplanin, a glycopeptide antibiotic, potently prevents the entry of Ebola envelope pseudotyped viruses into the cytoplasm. Furthermore, teicoplanin also has an inhibitory effect on transcription- and replication-competent virus-like particles, with an IC50 as low as 330 nm. Comparative analysis further demonstrated that teicoplanin is able to block the entry of Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS) envelope pseudotyped viruses as well. Teicoplanin derivatives such as dalbavancin, oritavancin, and telavancin can also inhibit the entry of Ebola, MERS, and SARS viruses. Mechanistic studies showed that teicoplanin blocks Ebola virus entry by specifically inhibiting the activity of cathepsin L, opening a novel avenue for the development of additional glycopeptides as potential inhibitors of cathepsin L-dependent viruses. Notably, given that teicoplanin has routinely been used in the clinic with low toxicity, our work provides a promising prospect for the prophylaxis and treatment of Ebola, MERS, and SARS virus infection. PMID:26953343

  9. Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants.

    Directory of Open Access Journals (Sweden)

    Damon Deming

    2006-12-01

    Full Text Available In 2003, severe acute respiratory syndrome coronavirus (SARS-CoV was identified as the etiological agent of severe acute respiratory syndrome, a disease characterized by severe pneumonia that sometimes results in death. SARS-CoV is a zoonotic virus that crossed the species barrier, most likely originating from bats or from other species including civets, raccoon dogs, domestic cats, swine, and rodents. A SARS-CoV vaccine should confer long-term protection, especially in vulnerable senescent populations, against both the 2003 epidemic strains and zoonotic strains that may yet emerge from animal reservoirs. We report the comprehensive investigation of SARS vaccine efficacy in young and senescent mice following homologous and heterologous challenge.Using Venezuelan equine encephalitis virus replicon particles (VRP expressing the 2003 epidemic Urbani SARS-CoV strain spike (S glycoprotein (VRP-S or the nucleocapsid (N protein from the same strain (VRP-N, we demonstrate that VRP-S, but not VRP-N vaccines provide complete short- and long-term protection against homologous strain challenge in young and senescent mice. To test VRP vaccine efficacy against a heterologous SARS-CoV, we used phylogenetic analyses, synthetic biology, and reverse genetics to construct a chimeric virus (icGDO3-S encoding a synthetic S glycoprotein gene of the most genetically divergent human strain, GDO3, which clusters among the zoonotic SARS-CoV. icGD03-S replicated efficiently in human airway epithelial cells and in the lungs of young and senescent mice, and was highly resistant to neutralization with antisera directed against the Urbani strain. Although VRP-S vaccines provided complete short-term protection against heterologous icGD03-S challenge in young mice, only limited protection was seen in vaccinated senescent animals. VRP-N vaccines not only failed to protect from homologous or heterologous challenge, but resulted in enhanced immunopathology with eosinophilic

  10. SARS - Diagnosis

    Indian Academy of Sciences (India)

    SARS - Diagnosis. Mainly by exclusion of known causes of atypical pneumonia; * X ray Chest; * PCR on body fluids- primers defined by WHO centres available from website.-ve result does not exclude SARS. * Sequencing of amplicons; * Viral Cultures – demanding; * Antibody tests.

  11. The nucleocapsid proteins of mouse hepatitis virus and severe acute respiratory syndrome coronavirus share the same IFN-β antagonizing mechanism: attenuation of PACT-mediated RIG-I/ MDA5 activation.

    Science.gov (United States)

    Ding, Zhen; Fang, Liurong; Yuan, Shuangling; Zhao, Ling; Wang, Xunlei; Long, Siwen; Wang, Mohan; Wang, Dang; Foda, Mohamed Frahat; Xiao, Shaobo

    2017-07-25

    Coronaviruses (CoVs) are a huge threat to both humans and animals and have evolved elaborate mechanisms to antagonize interferons (IFNs). Nucleocapsid (N) protein is the most abundant viral protein in CoV-infected cells, and has been identified as an innate immunity antagonist in several CoVs, including mouse hepatitis virus (MHV) and severe acute respiratory syndrome (SARS)-CoV. However, the underlying molecular mechanism(s) remain unclear. In this study, we found that MHV N protein inhibited Sendai virus and poly(I:C)-induced IFN-β production by targeting a molecule upstream of retinoic acid-induced gene I (RIG-I) and melanoma differentiation gene 5 (MDA5). Further studies showed that both MHV and SARS-CoV N proteins directly interacted with protein activator of protein kinase R (PACT), a cellular dsRNA-binding protein that can bind to RIG-I and MDA5 to activate IFN production. The N-PACT interaction sequestered the association of PACT and RIG-I/MDA5, which in turn inhibited IFN-β production. However, the N proteins from porcine epidemic diarrhea virus (PEDV) and porcine reproductive and respiratory syndrome virus (PRRSV), which are also classified in the order Nidovirales, did not interact and counteract with PACT. Taken together, our present study confirms that both MHV and SARS-CoV N proteins can perturb the function of cellular PACT to circumvent the innate antiviral response. However, this strategy does not appear to be used by all CoVs N proteins.

  12. The potential of targeted antibody prophylaxis in SARS outbreak control: a mathematic analysis

    NARCIS (Netherlands)

    Bogaards, Johannes Antonie; Putter, Hein; Jan Weverling, Gerrit; ter Meulen, Jan; Goudsmit, Jaap

    2007-01-01

    BACKGROUND: Severe acute respiratory syndrome (SARS) coronavirus-like viruses continue to circulate in animal reservoirs. If new mutants of SARS coronavirus do initiate another epidemic, administration of prophylactic antibodies to risk groups may supplement the stringent isolation procedures that

  13. Severe Acute Respiratory Syndrome- SARS

    Indian Academy of Sciences (India)

    SARS – clinical features · Radiological features of lungs-showing progression of disease · cT Scan of SARS lungs · Imaging type,cost,therapy · SARS – Lung Pathology · SARS Pathology · SARS - Diagnosis · How did SARS spread ? Economics of Epidemics -SARS · How was SARS contained so fast ? Slide 16 · Slide 17.

  14. Geodetic SAR Tomography

    NARCIS (Netherlands)

    Zhu, Xiao Xiang; Montazeri, Sina; Gisinger, Christoph; Hanssen, R.F.; Bamler, Richard

    2016-01-01

    In this paper, we propose a framework referred to as 'geodetic synthetic aperture radar (SAR) tomography' that fuses the SAR imaging geodesy and tomographic SAR inversion (TomoSAR) approaches to obtain absolute 3-D positions of a large amount of natural scatterers. The methodology is applied on

  15. Molecular mechanisms of severe acute respiratory syndrome (SARS

    Directory of Open Access Journals (Sweden)

    Zabel Peter

    2005-01-01

    Full Text Available Abstract Severe acute respiratory syndrome (SARS is a new infectious disease caused by a novel coronavirus that leads to deleterious pulmonary pathological features. Due to its high morbidity and mortality and widespread occurrence, SARS has evolved as an important respiratory disease which may be encountered everywhere in the world. The virus was identified as the causative agent of SARS due to the efforts of a WHO-led laboratory network. The potential mutability of the SARS-CoV genome may lead to new SARS outbreaks and several regions of the viral genomes open reading frames have been identified which may contribute to the severe virulence of the virus. With regard to the pathogenesis of SARS, several mechanisms involving both direct effects on target cells and indirect effects via the immune system may exist. Vaccination would offer the most attractive approach to prevent new epidemics of SARS, but the development of vaccines is difficult due to missing data on the role of immune system-virus interactions and the potential mutability of the virus. Even in a situation of no new infections, SARS remains a major health hazard, as new epidemics may arise. Therefore, further experimental and clinical research is required to control the disease.

  16. Simultaneous Genomic Detection of Multiple Enteric Bacterial and Viral Pathogens, Including Sars-CoV and RVFV

    National Research Council Canada - National Science Library

    Payne, S; Peters, C. J. (Clarence James), 1940; Makino, S; Oliver, K; Weiss, C; Kornguth, S; Carruthers, L; Chin, R

    2004-01-01

    ...) associated with the SARS-associated coronavirus (SARS-CoV) and Rift Valley Fever Virus (RVFV) has been developed. This system is based upon the Luminex xMAP" System, a multiplexed assay platform that combines high sample throughput...

  17. Expression of a hantavirus N protein and its efficacy as antigen in immune assays

    Directory of Open Access Journals (Sweden)

    L.T.M. Figueiredo

    2008-07-01

    Full Text Available Hantavirus cardiopulmonary syndrome (HCPS has been recognized as an important public heath problem. Five hantaviruses associated with HCPS are currently known in Brazil: Juquitiba, Araraquara, Laguna Negra-like, Castelo dos Sonhos, and Anajatuba viruses. The laboratory diagnosis of HCPS is routinely carried out by the detection of anti-hantavirus IgM and/or IgG antibodies. The present study describes the expression of the N protein of a hantavirus detected in the blood sample of an HCPS patient. The entire S segment of the virus was amplified and found to be 1858 nucleotides long, with an open reading frame of 1287 nucleotides that encodes a protein of 429 amino acids. The nucleotide sequence described here showed a high identity with the N protein gene of Araraquara virus. The entire N protein was expressed using the vector pET200D and the Escherichia coli BL21 strain. The expression of the recombinant protein was confirmed by the detection of a 52-kDa protein by Western blot using a pool of human sera obtained from HCPS patients, and by specific IgG detection in five serum samples of HCPS patients tested by ELISA. These results suggest that the recombinant N protein could be used as an antigen for the serological screening of hantavirus infection.

  18. Severe Acute Respiratory Syndrome- SARS

    Indian Academy of Sciences (India)

    Table of contents. Severe Acute Respiratory Syndrome- SARS · PowerPoint Presentation · Slide 3 · Global pattern of SARS epidemic · Slide 5 · SARS – clinical features · Radiological features of lungs-showing progression of disease · cT Scan of SARS lungs · Imaging type,cost,therapy · SARS – Lung Pathology.

  19. Studies on synthesis and structure-activity relationship (SAR) of derivatives of a new natural product from marine fungi as inhibitors of influenza virus neuraminidase.

    Science.gov (United States)

    Li, Jing; Zhang, Dingmei; Zhu, Xun; He, Zhenjian; Liu, Shu; Li, Mengfeng; Pang, Jiyan; Lin, Yongcheng

    2011-01-01

    Based on the natural isoprenyl phenyl ether from a mangrove-derived fungus, 32 analogues were synthesized and evaluated for inhibitory activity against influenza H1N1 neuraminidase. Compound 15 (3-(allyloxy)-4-hydroxybenzaldehyde) exhibited the most potent inhibitory activity, with IC(50) values of 26.96 μM for A/GuangdongSB/01/2009 (H1N1), 27.73 μM for A/Guangdong/03/2009 (H1N1), and 25.13 μM for A/Guangdong/ 05/2009 (H1N1), respectively, which is stronger than the benzoic acid derivatives (~mM level). These are a new kind of non-nitrogenous aromatic ether Neuraminidase (NA) inhibitors. Their structures are simple and the synthesis routes are not complex. The structure-activity relationship (SAR) analysis revealed that the aryl aldehyde and unsubstituted hydroxyl were important to NA inhibitory activities. Molecular docking studies were carried out to explain the SAR of the compounds, and provided valuable information for further structure modification.

  20. Studies on Synthesis and Structure-Activity Relationship (SAR of Derivatives of a New Natural Product from Marine Fungi as Inhibitors of Influenza Virus Neuraminidase

    Directory of Open Access Journals (Sweden)

    Yongcheng Lin

    2011-10-01

    Full Text Available Based on the natural isoprenyl phenyl ether from a mangrove-derived fungus, 32 analogues were synthesized and evaluated for inhibitory activity against influenza H1N1 neuraminidase. Compound 15 (3-(allyloxy-4-hydroxybenzaldehyde exhibited the most potent inhibitory activity, with IC50 values of 26.96 μM for A/GuangdongSB/01/2009 (H1N1, 27.73 μM for A/Guangdong/03/2009 (H1N1, and 25.13 μM for A/Guangdong/05/2009 (H1N1, respectively, which is stronger than the benzoic acid derivatives (~mM level. These are a new kind of non-nitrogenous aromatic ether Neuraminidase (NA inhibitors. Their structures are simple and the synthesis routes are not complex. The structure-activity relationship (SAR analysis revealed that the aryl aldehyde and unsubstituted hydroxyl were important to NA inhibitory activities. Molecular docking studies were carried out to explain the SAR of the compounds, and provided valuable information for further structure modification.

  1. Peptide Mimicrying Between SARS Coronavirus Spike Protein and Human Proteins Reacts with SARS Patient Serum

    Directory of Open Access Journals (Sweden)

    K.-Y. Hwa

    2008-01-01

    Full Text Available Molecular mimicry, defined as similar structures shared by molecules from dissimilar genes or proteins, is a general strategy used by pathogens to infect host cells. Severe acute respiratory syndrome (SARS is a new human respiratory infectious disease caused by SARS coronavirus (SARS-CoV. The spike (S protein of SARS-CoV plays an important role in the virus entry into a cell. In this study, eleven synthetic peptides from the S protein were selected based on its sequence homology with human proteins. Two of the peptides D07 (residues 927–937 and D08 (residues 942–951 were recognized by the sera of SARS patients. Murine hyperimmune sera against these peptides bound to proteins of human lung epithelial cells A549. Another peptide D10 (residues 490–502 stimulated A549 to proliferate and secrete IL-8. The present results suggest that the selected S protein regions, which share sequence homology with human proteins, may play important roles in SARS-CoV infection.

  2. SAR: Stroke Authorship Recognition

    KAUST Repository

    Shaheen, Sara

    2015-10-15

    Are simple strokes unique to the artist or designer who renders them? If so, can this idea be used to identify authorship or to classify artistic drawings? Also, could training methods be devised to develop particular styles? To answer these questions, we propose the Stroke Authorship Recognition (SAR) approach, a novel method that distinguishes the authorship of 2D digitized drawings. SAR converts a drawing into a histogram of stroke attributes that is discriminative of authorship. We provide extensive classification experiments on a large variety of data sets, which validate SAR\\'s ability to distinguish unique authorship of artists and designers. We also demonstrate the usefulness of SAR in several applications including the detection of fraudulent sketches, the training and monitoring of artists in learning a particular new style and the first quantitative way to measure the quality of automatic sketch synthesis tools. © 2015 The Eurographics Association and John Wiley & Sons Ltd.

  3. From genome to antivirals: SARS as a test tube.

    Science.gov (United States)

    Kliger, Yossef; Levanon, Erez Y; Gerber, Doron

    2005-03-01

    The severe acute respiratory syndrome (SARS) epidemic brought into the spotlight the need for rapid development of effective anti-viral drugs against newly emerging viruses. Researchers have leveraged the 20-year battle against AIDS into a variety of possible treatments for SARS. Most prominently, based solely on viral genome information, silencers of viral genes, viral-enzyme blockers and viral-entry inhibitors were suggested as potential therapeutic agents for SARS. In particular, inhibitors of viral entry, comprising therapeutic peptides, were based on the recently launched anti-HIV drug enfuvirtide. This could represent one of the most direct routes from genome sequencing to the discovery of antiviral drugs.

  4. Persistent infection of SARS coronavirus in colonic cells in vitro.

    Science.gov (United States)

    Chan, Paul K S; To, Ka-Fai; Lo, Anthony W I; Cheung, Jo L K; Chu, Ida; Au, Florence W L; Tong, Joanna H M; Tam, John S; Sung, Joseph J Y; Ng, Ho-Keung

    2004-09-01

    Severe acute respiratory syndrome coronavirus (SARS-CoV) can produce gastrointestinal symptoms. The intestinal tract is the only extrapulmonary site where viable viruses have been detected. This study examined seven established human intestinal cell lines, DLD-1, HCT-116, HT-29, LoVo, LS-180, SW-480 and SW-620, for their permissiveness to SARS-CoV infection. The results showed that only LoVo cells were permissive to SARS-CoV infection as evident by positive findings from indirect immunofluorescence staining for intracellular viral antigens, in situ hybridization for intracellular viral RNA, and electron microscopy for intracellular viral particles. In contrast to Vero cells, SARS-CoV did not produce cytopathic effects on LoVo cells. However, LoVo cells were found to be highly permissive for productive infection with a high viral titre (>3 x 10(7) viral copies/ml) produced in culture supernatant following a few days of incubation. SARS-CoV established a stable persistent chronic infection that could be maintained after multiple passages. Being a cell line of human origin, LoVo cells could be a useful in vitro model for studying the biology and persistent infection of SARS-CoV. Our results on the expression of angiotensin-converting enzyme 2 (ACE2), a recently identified cellular receptor for SARS-CoV, in these cell lines indicated that it might not be the sole determinant for cells to be susceptible to SARS-CoV infection.

  5. SARS – clinical features

    Indian Academy of Sciences (India)

    SARS – clinical features. Fever - > 38C; Respiratory symptoms, eg cough, difficulty in breathing; OR; Unexplained respiratory distress leading to death; AND; Close contact or travel to Asia within 10 days of onset of illness.

  6. Lack of innate interferon responses during SARS coronavirus infection in a vaccination and reinfection ferret model.

    Directory of Open Access Journals (Sweden)

    Mark J Cameron

    Full Text Available In terms of its highly pathogenic nature, there remains a significant need to further define the immune pathology of SARS-coronavirus (SARS-CoV infection, as well as identify correlates of immunity to help develop vaccines for severe coronaviral infections. Here we use a SARS-CoV infection-reinfection ferret model and a functional genomics approach to gain insight into SARS immunopathogenesis and to identify correlates of immune protection during SARS-CoV-challenge in ferrets previously infected with SARS-CoV or immunized with a SARS virus vaccine. We identified gene expression signatures in the lungs of ferrets associated with primary immune responses to SARS-CoV infection and in ferrets that received an identical second inoculum. Acute SARS-CoV infection prompted coordinated innate immune responses that were dominated by antiviral IFN response gene (IRG expression. Reinfected ferrets, however, lacked the integrated expression of IRGs that was prevalent during acute infection. The expression of specific IRGs was also absent upon challenge in ferrets immunized with an inactivated, Al(OH(3-adjuvanted whole virus SARS vaccine candidate that protected them against SARS-CoV infection in the lungs. Lack of IFN-mediated immune enhancement in infected ferrets that were previously inoculated with, or vaccinated against, SARS-CoV revealed 9 IRG correlates of protective immunity. This data provides insight into the molecular pathogenesis of SARS-CoV and SARS-like-CoV infections and is an important resource for the development of CoV antiviral therapeutics and vaccines.

  7. Modeling the structure of SARS 3a transmembrane protein using a ...

    Indian Academy of Sciences (India)

    The causative agent of this atypical form of pneu- monia has been identified as SARS-associated coron- avirus (SARS-CoV).4,5 Although this virus has a posi- tive stranded RNA genome that is characteristic of coro- naviruses, it has been shown to be phylogenetically different from other coronaviruses.6,7 The genome has.

  8. Improving the selection and development of influenza vaccine viruses - Report of a WHO informal consultation on improving influenza vaccine virus selection, Hong Kong SAR, China, 18-20 November 2015.

    Science.gov (United States)

    Hampson, Alan; Barr, Ian; Cox, Nancy; Donis, Ruben O; Siddhivinayak, Hirve; Jernigan, Daniel; Katz, Jacqueline; McCauley, John; Motta, Fernando; Odagiri, Takato; Tam, John S; Waddell, Anthony; Webby, Richard; Ziegler, Thedi; Zhang, Wenqing

    2017-02-22

    Since 2010 the WHO has held a series of informal consultations to explore ways of improving the currently highly complex and time-pressured influenza vaccine virus selection and development process. In November 2015 experts from around the world met to review the current status of efforts in this field. Discussion topics included strengthening influenza surveillance activities to increase the availability of candidate vaccine viruses and improve the extent, timeliness and quality of surveillance data. Consideration was also given to the development and potential application of newer laboratory assays to better characterize candidate vaccine viruses, the potential importance of antibodies directed against influenza virus neuraminidase, and the role of vaccine effectiveness studies. Advances in next generation sequencing and whole genome sequencing of influenza viruses were also discussed, along with associated developments in synthetic genomics technologies, evolutionary analysis and predictive mathematical modelling. Discussions were also held on the late emergence of an antigenic variant influenza A(H3N2) virus in mid-2014 that could not be incorporated in time into the 2014-15 northern hemisphere vaccine. There was broad recognition that given the current highly constrained influenza vaccine development and production timeline it would remain impossible to incorporate any variant virus which emerged significantly long after the relevant WHO biannual influenza vaccine composition meetings. Discussions were also held on the development of pandemic and broadly protective vaccines, and on associated regulatory and manufacturing requirements and constraints. With increasing awareness of the health and economic burdens caused by seasonal influenza, the ever-present threat posed by zoonotic influenza viruses, and the significant impact of the 2014-15 northern hemisphere seasonal influenza vaccine mismatch, this consultation provided a very timely opportunity to share

  9. Adventures in SAR processing

    Science.gov (United States)

    Fiedler, Ralph; Jansen, Robert

    2000-04-01

    The image formation process associated with coherent imaging sensor is particularly sensitive to and is often corrupted by non-stationary processes. In the case of SAR, non- stationary processes result from motion within the scene, variable radar cross section, multi-path, topographic variations, sensor anomalies, and deficiencies in the image formation processing chain. Conversely, stationary processes result in image signatures that appear literal to the eye, e.g., urban infrastructure, vegetation, and natural terrain. In analyzing SAR signal history two objectives unfold. One is to obtain a well-focused image devoid of distortions and non-literal artifacts. The second objective is the detection and value-added exploitation of the non-stationary signatures. Note that the roles of signal and clutter are reversed for these two objectives. The notion that joint time-frequency (JTF) techniques may prove useful in accomplishing these objectives has spurred limited investigations into the field of coherent radar imaging systems. This paper addresses SAR image formation processing, the complex response function for a point source, and SAR JTF image formation implementations. Each of these topics is described within the context of applying JTF processing to all aspects of SAR image formation and analysis.

  10. Severe acute respiratory syndrome (SARS)

    Science.gov (United States)

    ... their fever and other symptoms are gone. Hand hygiene is the most important part of SARS prevention. ... Coronaviruses, including severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). In: Bennett JE, Dolin ...

  11. The experience of SARS-related stigma at Amoy Gardens.

    Science.gov (United States)

    Lee, Sing; Chan, Lydia Y Y; Chau, Annie M Y; Kwok, Kathleen P S; Kleinman, Arthur

    2005-11-01

    Severe Acute Respiratory Syndrome (SARS) possesses characteristics that render it particularly prone to stigmatization. SARS-related stigma, despite its salience for public health and stigma research, has had little examination. This study combines survey and case study methods to examine subjective stigma among residents of Amoy Gardens (AG), the first officially recognized site of community outbreak of SARS in Hong Kong. A total of 903 residents of AG completed a self-report questionnaire derived from two focus groups conducted toward the end of the 3-month outbreak. Case studies of two residents who lived in Block E, the heart of the SARS epidemic at AG, complement the survey data. Findings show that stigma affected most residents and took various forms of being shunned, insulted, marginalized, and rejected in the domains of work, interpersonal relationships, use of services and schooling. Stigma was also associated with psychosomatic distress. Residents' strategies for diminishing stigma varied with gender, age, education, occupation, and proximity to perceived risk factors for SARS such as residential location, previous SARS infection and the presence of ex-SARS household members. Residents attributed stigma to government mismanagement, contagiousness of the mysterious SARS virus, and alarmist media reporting. Stigma clearly decreased, but never completely disappeared, after the outbreak. The findings confirm and add to existing knowledge on the varied origins, correlates, and impacts of stigma. They also highlight the synergistic roles of inconsistent health policy responses and risk miscommunication by the media in rapidly amplifying stigma toward an unfamiliar illness. While recognizing the intrinsically stigmatizing nature of public health measures to control SARS, we recommend that a consistent inter-sectoral approach is needed to minimize stigma and to make an effective health response to future outbreaks.

  12. Data Analytics for SAR

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, David Patrick [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Calef, Matthew Thomas [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-10-02

    We assess the ability of variants of anomalous change detection (ACD) to identify human activity associated with large outdoor music festivals as they are seen from synthetic aperture radar (SAR) imagery collected by the Sentinel-1 satellite constellation. We found that, with appropriate feature vectors, ACD using random-forest machine learning was most effective at identifying changes associated with the human activity.

  13. Multichannel FMCW SAR

    NARCIS (Netherlands)

    Rossum, W.L. van; Otten, M.P.G.; Dorp, Ph. van

    2012-01-01

    A light weight SAR, suitable for use on short range tactical UAV, has been designed and built. The system consists of a fully digital receive array, and a very compact active transmit antenna. The approximate weight of the complete system is 6 kg, with power consumption below 75 W, depending on the

  14. Bistatic SAR: Proof of Concept.

    Energy Technology Data Exchange (ETDEWEB)

    Yocky, David A.; Doren, Neall E.; Bacon, Terry A.; Wahl, Daniel E.; Eichel, Paul H.; Jakowatz, Charles V,; Delaplain, Gilbert G.; Dubbert, Dale F.; Tise, Bertice L.; White, Kyle R.

    2014-10-01

    Typical synthetic aperture RADAR (SAR) imaging employs a co-located RADAR transmitter and receiver. Bistatic SAR imaging separates the transmitter and receiver locations. A bistatic SAR configuration allows for the transmitter and receiver(s) to be in a variety of geometric alignments. Sandia National Laboratories (SNL) / New Mexico proposed the deployment of a ground-based RADAR receiver. This RADAR receiver was coupled with the capability of digitizing and recording the signal collected. SNL proposed the possibility of creating an image of targets the illuminating SAR observes. This document describes the developed hardware, software, bistatic SAR configuration, and its deployment to test the concept of a ground-based bistatic SAR. In the proof-of-concept experiments herein, the RADAR transmitter will be a commercial SAR satellite and the RADAR receiver will be deployed at ground level, observing and capturing RADAR ground/targets illuminated by the satellite system.

  15. Bistatic sAR data processing algorithms

    CERN Document Server

    Qiu, Xiaolan; Hu, Donghui

    2013-01-01

    Synthetic Aperture Radar (SAR) is critical for remote sensing. It works day and night, in good weather or bad. Bistatic SAR is a new kind of SAR system, where the transmitter and receiver are placed on two separate platforms. Bistatic SAR is one of the most important trends in SAR development, as the technology renders SAR more flexible and safer when used in military environments. Imaging is one of the most difficult and important aspects of bistatic SAR data processing. Although traditional SAR signal processing is fully developed, bistatic SAR has a more complex system structure, so sign

  16. SAR++: A Multi-Channel Scalable and Reconfigurable SAR System

    DEFF Research Database (Denmark)

    Høeg, Flemming; Christensen, Erik Lintz

    2002-01-01

    SAR++ is a technology program aiming at developing know-how and technology needed to design the next generation civilian SAR systems. Technology has reached a state, which allows major parts of the digital subsystem to be built using custom-off-the-shelf (COTS) components. A design goal is to des......SAR++ is a technology program aiming at developing know-how and technology needed to design the next generation civilian SAR systems. Technology has reached a state, which allows major parts of the digital subsystem to be built using custom-off-the-shelf (COTS) components. A design goal...... is to design a modular, scalable and reconfigurable SAR system using such components, in order to ensure maximum flexibility for the users of the actual system and for future system updates. Having these aspects in mind the SAR++ system is presented with focus on the digital subsystem architecture...... and the analog to digital interface....

  17. 3D SAR approach to IF SAR processing

    Science.gov (United States)

    Doerry, Armin W.; Bickel, Doug

    2000-08-01

    Interferometric SAR (IFSAR) can be shown to be a special case of 3-D SAR image formation. In fact, traditional IFSAR processing results in the equivalent of merely a super- resolved, under-sampled, 3-D SAR image. However, when approached as a 3-D SAR problem, a number of IFSAR properties and anomalies are easily explained. For example, IFSAR decorrelation with height is merely ordinary migration in 3-D SAR. Consequently, treating IFSAR as a 3-D SAR problem allows insight and development of proper motion compensation techniques and image formation operations to facilitate optimal height estimation. Furthermore, multiple antenna phase centers and baselines are easily incorporated into this formulation, providing essentially a sparse array in the elevation dimension. This paper shows the Polar Format image formation algorithm extended to 3 dimensions, and then proceeds to apply it to the IFSAR collection geometry. This suggests a more optimal reordering of the traditional IFSAR processing steps.

  18. Excretion and detection of SARS coronavirus and its nucleic acid from digestive system

    Science.gov (United States)

    Wang, Xin-Wei; Li, Jin-Song; Guo, Ting-Kai; Zhen, Bei; Kong, Qing-Xin; Yi, Bin; Li, Zhong; Song, Nong; Jin, Min; Wu, Xiao-Ming; Xiao, Wen-Jun; Zhu, Xiu-Mei; Gu, Chang-Qing; Yin, Jing; Wei, Wei; Yao, Wei; Liu, Chao; Li, Jian-Feng; Ou, Guo-Rong; Wang, Min-Nian; Fang, Tong-Yu; Wang, Gui-Jie; Qiu, Yao-Hui; Wu, Huai-Huan; Chao, Fu-Huan; Li, Jun-Wen

    2005-01-01

    AIM: To study whether severe acute respiratory syndrome coronavirus (SARS-CoV) could be excreted from digestive system. METHODS: Cell culture and semi-nested RT-PCR were used to detect SARS-CoV and its RNA from 21 stool and urine samples, and a kind of electropositive filter media particles was used to concentrate the virus in 10 sewage samples from two hospitals receiving SARS patients in Beijing in China. RESULTS: It was demonstrated that there was no live SARS-CoV in all samples collected, but the RNA of SARS-CoV could be detected in seven stool samples from SARS patients with any one of the symptoms of fever, malaise, cough, or dyspnea, in 10 sewage samples before disinfection and 3 samples after disinfection from the two hospitals. The RNA could not be detected in urine and stool samples from patients recovered from SARS. CONCLUSION: Nucleic acid of SARS-CoV can be excreted through the stool of patients into sewage system, and the possibility of SARS-CoV transmitting through digestive system cannot be excluded. PMID:16038039

  19. Wetland InSAR

    Science.gov (United States)

    Wdowinski, S.; Kim, S.; Amelung, F.; Dixon, T.

    2006-12-01

    Wetlands are transition zones where the flow of water, the nutrient cycling, and the sun energy meet to produce a unique and very productive ecosystem. They provide critical habitat for a wide variety of plant and animal species, including the larval stages of many ocean fish. Wetlands also have a valuable economical importance, as they filter nutrients and pollutants from fresh water used by human and provide aquatic habitats for outdoor recreation, tourism, and fishing. Globally, many such regions are under severe environmental stress, mainly from urban development, pollution, and rising sea level. However, there is increasing recognition of the importance of these habitats, and mitigation and restoration activities have begun in a few regions. A key element in wetlands conservation, management, and restoration involves monitoring its hydrologic system, as the entire ecosystem depends on its water supply. Heretofore, hydrologic monitoring of wetlands are conducted by stage (water level) stations, which provide good temporal resolution, but suffer from poor spatial resolution, as stage station are typically distributed several, or even tens of kilometers, from one another. Wetland application of InSAR provides the needed high spatial resolution hydrological observations, complementing the high temporal resolution terrestrial observations. Although conventional wisdom suggests that interferometry does not work in vegetated areas, several studies have shown that both L- and C-band interferograms with short acquisition intervals (1-105 days) can maintain excellent coherence over wetlands. In this study we explore the usage of InSAR for detecting water level changes in various wetland environments around the world, including the Everglades (south Florida), Louisiana Coast (southern US), Chesapeake Bay (eastern US), Pantanal (Brazil), Okavango Delta (Botswana), and Lena Delta (Siberia). Our main study area is the Everglades wetland (south Florida), which is covered by

  20. Novel Polarimetric SAR Interferometry Algorithms, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Polarimetric SAR interferometry (PolInSAR) is a recently developed synthetic aperture radar (SAR) imaging mode that combines the capabilities of radar polarimetry...

  1. [SARS, possible zoonosis in the area of conflict of pathogenic coronaviruses of animals].

    Science.gov (United States)

    Tobler, K; Ackermann, M; Griot, C

    2003-07-01

    Severe acute respiratory syndrome (SARS) is an emerging disease, which was first recognized in Guangdong Province, China, in November 2002. In the meantime, SARS has been recognized in patients on all five continents. A novel coronavirus, which is not related to the hitherto known coronaviruses, has been proven to be associated with the disease. Our genomic analyses strongly suggest that the new SARS-coronavirus did not emerge through mutation or recombination and that it has probably been transmitted from a so far not identified animal species to humans. Therefore, it is most likely that SARS virus is a zoonotic agent. A broad body of knowledge originating from research in veterinary medicine indicates that development of vaccines against the SARS-coronavirus may be problematic. The potential danger of such vaccines should not be neglected during the process of vaccine development.

  2. Demonstration MTI/SAR capability

    NARCIS (Netherlands)

    Vries, F.P.P. de; Broek, A.C. van den; Otten, M.P.G.; Groot, J.S.; Steeghs, T.P.H.; Dekker, R.J.; Rossum, W.L. van

    2001-01-01

    The aim of this project is to demonstrate to the Dutch armed forces the capability of MTI (Moving Target Indicator) and SAR (Synthetic Aperture Radar). This is done with the Dutch PHARUS sensor. The sensor is used to demonstrate how a phased array antenna can be used as an MTI/SAR sensor

  3. PHARUS : PHased ARray Universal SAR

    NARCIS (Netherlands)

    Paquay, M.H.A.; Vermeulen, B.C.B.; Koomen, P.J.; Hoogeboom, P.; Snoeij, P.; Pouwels, H.

    1996-01-01

    In the Netherlands, a polarimetric C-band aircraft SAR (Synthetic Aperture Radar) has been developed. The project is called PHARUS, an acronm for PHased ARray Universal SAR. This instrument serves remote sensing applications. The antenna system contains 48 active modules (expandable to 96). A module

  4. Bistatic SAR: Imagery & Image Products.

    Energy Technology Data Exchange (ETDEWEB)

    Yocky, David A.; Wahl, Daniel E.; Jakowatz, Charles V,

    2014-10-01

    While typical SAR imaging employs a co-located (monostatic) RADAR transmitter and receiver, bistatic SAR imaging separates the transmitter and receiver locations. The transmitter and receiver geometry determines if the scattered signal is back scatter, forward scatter, or side scatter. The monostatic SAR image is backscatter. Therefore, depending on the transmitter/receiver collection geometry, the captured imagery may be quite different that that sensed at the monostatic SAR. This document presents imagery and image products formed from captured signals during the validation stage of the bistatic SAR research. Image quality and image characteristics are discussed first. Then image products such as two-color multi-view (2CMV) and coherent change detection (CCD) are presented.

  5. High Resolution Processing with an Active Phased Array SAR

    NARCIS (Netherlands)

    Nijenboer, F.J.; Otten, M.P.G.

    1999-01-01

    The Dutch PHARUS system is a polarimetric active phased array SAR capable of performing advanced SAR modes. Advanced SAR modes that are being investigated are: spotlight SAR, sliding spotlight SAR, stepped frequency SAR and interferometric SAR. The flight experiments and automatic beam steering

  6. The SARS-unique domain (SUD of SARS coronavirus contains two macrodomains that bind G-quadruplexes.

    Directory of Open Access Journals (Sweden)

    Jinzhi Tan

    2009-05-01

    Full Text Available Since the outbreak of severe acute respiratory syndrome (SARS in 2003, the three-dimensional structures of several of the replicase/transcriptase components of SARS coronavirus (SARS-CoV, the non-structural proteins (Nsps, have been determined. However, within the large Nsp3 (1922 amino-acid residues, the structure and function of the so-called SARS-unique domain (SUD have remained elusive. SUD occurs only in SARS-CoV and the highly related viruses found in certain bats, but is absent from all other coronaviruses. Therefore, it has been speculated that it may be involved in the extreme pathogenicity of SARS-CoV, compared to other coronaviruses, most of which cause only mild infections in humans. In order to help elucidate the function of the SUD, we have determined crystal structures of fragment 389-652 ("SUD(core" of Nsp3, which comprises 264 of the 338 residues of the domain. Both the monoclinic and triclinic crystal forms (2.2 and 2.8 A resolution, respectively revealed that SUD(core forms a homodimer. Each monomer consists of two subdomains, SUD-N and SUD-M, with a macrodomain fold similar to the SARS-CoV X-domain. However, in contrast to the latter, SUD fails to bind ADP-ribose, as determined by zone-interference gel electrophoresis. Instead, the entire SUD(core as well as its individual subdomains interact with oligonucleotides known to form G-quadruplexes. This includes oligodeoxy- as well as oligoribonucleotides. Mutations of selected lysine residues on the surface of the SUD-N subdomain lead to reduction of G-quadruplex binding, whereas mutations in the SUD-M subdomain abolish it. As there is no evidence for Nsp3 entering the nucleus of the host cell, the SARS-CoV genomic RNA or host-cell mRNA containing long G-stretches may be targets of SUD. The SARS-CoV genome is devoid of G-stretches longer than 5-6 nucleotides, but more extended G-stretches are found in the 3'-nontranslated regions of mRNAs coding for certain host-cell proteins

  7. Palmitoylation of SARS-CoV S protein is necessary for partitioning into detergent-resistant membranes and cell-cell fusion but not interaction with M protein

    International Nuclear Information System (INIS)

    McBride, Corrin E.; Machamer, Carolyn E.

    2010-01-01

    Coronaviruses are enveloped RNA viruses that generally cause mild disease in humans. However, the recently emerged coronavirus that caused severe acute respiratory syndrome (SARS-CoV) is the most pathogenic human coronavirus discovered to date. The SARS-CoV spike (S) protein mediates virus entry by binding cellular receptors and inducing fusion between the viral envelope and the host cell membrane. Coronavirus S proteins are palmitoylated, which may affect function. Here, we created a non-palmitoylated SARS-CoV S protein by mutating all nine cytoplasmic cysteine residues. Palmitoylation of SARS-CoV S was required for partitioning into detergent-resistant membranes and for cell-cell fusion. Surprisingly, however, palmitoylation of S was not required for interaction with SARS-CoV M protein. This contrasts with the requirement for palmitoylation of mouse hepatitis virus S protein for interaction with M protein and may point to important differences in assembly and infectivity of these two coronaviruses.

  8. TerraSAR-X mission

    Science.gov (United States)

    Werninghaus, Rolf

    2004-01-01

    The TerraSAR-X is a German national SAR- satellite system for scientific and commercial applications. It is the continuation of the scientifically and technologically successful radar missions X-SAR (1994) and SRTM (2000) and will bring the national technology developments DESA and TOPAS into operational use. The space segment of TerraSAR-X is an advanced high-resolution X-Band radar satellite. The system design is based on a sound market analysis performed by Infoterra. The TerraSAR-X features an advanced high-resolution X-Band Synthetic Aperture Radar based on the active phased array technology which allows the operation in Spotlight-, Stripmap- and ScanSAR Mode with various polarizations. It combines the ability to acquire high resolution images for detailed analysis as well as wide swath images for overview applications. In addition, experimental modes like the Dual Receive Antenna Mode allow for full-polarimetric imaging as well as along track interferometry, i.e. moving target identification. The Ground Segment is optimized for flexible response to (scientific and commercial) User requests and fast image product turn-around times. The TerraSAR-X mission will serve two main goals. The first goal is to provide the strongly supportive scientific community with multi-mode X-Band SAR data. The broad spectrum of scientific application areas include Hydrology, Geology, Climatology, Oceanography, Environmental Monitoring and Disaster Monitoring as well as Cartography (DEM Generation) and Interferometry. The second goal is the establishment of a commercial EO-market in Europe which is driven by Infoterra. The commercial goal is the development of a sustainable EO-business so that the e.g. follow-on systems can be completely financed by industry from the profit. Due to its commercial potential, the TerraSAR-X project will be implemented based on a public-private partnership with the Astrium GmbH. This paper will describe first the mission objectives as well as the

  9. Siyah Sarımsak

    Directory of Open Access Journals (Sweden)

    Selen Akan

    2015-02-01

    Full Text Available Sarımsağın insan sağlığına yararları yüzyıllardır yaygın olarak bilinmektedir. Besin içeriği nedeniyle uzmanların şiddetle tavsiye etmelerine ve beslenme programlarına mutlaka eklenilmesine rağmen keskin kokusu nedeniyle birçok kişi tüketmekten kaçınmaktadır. Sarımsağın bu dezavantajı için alternatif olarak siyah sarımsak gündeme getirilmiştir. Siyah sarımsak, taze sarımsağın fermente edilip, tamamen siyah rengini alana kadar koyu renge dönüşümü ile oluşmakta ve bu süreçte besin içeriği de değişim göstermektedir. Fermantasyon işlemi ile sarımsak başlarının karakteristik kokusunu veren öncül maddeleri alliin ve allicin azalmakta böylelikle hem istenmeyen kokusunu kaybetmekte hem de tadındaki acılık kaybolmaktadır. Siyah sarımsak, taze sarımsağa oranla yüksek oranda antioksidan aktiviteye sahiptir. Bu özelliği, sadece koku ve lezzet olarak değil, besin içeriğiyle de beslenme takviyesinde kullanımını daha çekici hale getirmiştir. Siyah sarımsak Asya ve Avrupa ülkelerinde henüz yeni beğeni toplamaya başlamıştır. Japonya ve Kore’de siyah sarımsak, anti kanserojen özellikleri ve aroması ile yemeklerde aparatif olarak kullanılmaktadır. Amerika Birleşik Devletleri, Kanada ve İngiltere’de de yoğun şekilde ticareti başlamıştır. Bu çalışmada, siyah sarımsak konusunda yapılan araştırmaların sonuçları derlenmiştir.

  10. [Epidemiological perspectives on SARS and avian influenza].

    Science.gov (United States)

    del Rey Calero, Juan

    2004-01-01

    SARS is a respiratory infection caused by Coronavirus (Nidoviruses, RNA) from which 3 groups are known. Group 1 affects dogs, cats, pigs, and the human agent is 229 E. Group 2 affects bovines or rodents, and the human agent is OC43. And group 3 corresponds to the avian pathology.... The epidemics emerged on February 2003 in Guangdong, South China, due to consumption of exotic animals (Civeta, etc.), and it spread through interperson contagion to other regions in Asia, America and Europe. Incubation period is about 2-7 days. Transmission Of the virus is person-to person, but also by excretions and residual water. Basic reproductive rate is 2 to 4, and it is considered that 2.7 persons are infected from the initial case. In June 2003, SARS affected over 8,000 people and 774 were killed. Mortality approaches to 10%, and it is higher among older people rising up to 50% in those aged over 65 years. It is important to quickly establish action protocols regarding clinical, epidemiological and prevention aspects. Avian influenza is an infection caused by type A Influenza Orthomixovirus, in which migration birds and wild ducks are the main reservoir. Avian viruses correspond to H5, H7, H9. In 1997 it was observed that type AH5N1 jumped interspecies barrier and affected 18 humans, and 6 of them died. At the end of 2003 and in 2004 this type of poultry flu was described in Asia. FAO has emphasized that sacrifice of chicken in affected farms is the most effective measure to fight against the disease. It has also been established suppression of imports from these countries. There is no evidence on interperson contagion from chicken contagion, nor on food-borne contagion to humans.

  11. The effect of inhibition of PP1 and TNFα signaling on pathogenesis of SARS coronavirus

    Energy Technology Data Exchange (ETDEWEB)

    McDermott, Jason E.; Mitchell, Hugh D.; Gralinski, Lisa E.; Eisfeld, Amie J.; Josset, Laurence; Bankhead, Armand; Neumann, Gabriele; Tilton, Susan C.; Schäfer, Alexandra; Li, Chengjun; Fan, Shufang; McWeeney, Shannon; Baric, Ralph S.; Katze, Michael G.; Waters, Katrina M.

    2016-09-23

    The complex interplay between viral replication and host immune response during infection remains poorly understood. While many viruses are known to employ antiimmune strategies to facilitate their replication, highly pathogenic virus infections can also cause an excessive immune response that exacerbates, rather than reduces pathogenicity. To investigate this dichotomy in severe acute respiratory syndrome coronavirus (SARS-CoV), we developed a transcriptional network model of SARS-CoV infection in mice and used the model to prioritize candidate regulatory targets for further investigation. We validated our predictions in 18 different knockout (KO) mouse strains, showing that network topology provides significant predictive power to identify genes that are important for viral infection. We identified a novel player in the immune response to virus infection, Kepi, an inhibitory subunit of the protein phosphatase 1 (PP1) complex, which protects against SARS-CoV pathogenesis. We also found that receptors for the proinflammatory cytokine, tumor necrosis factor alpha (TNFα), promote pathogenesis through a parallel feed-forward circuit that promotes inflammation. These results are consistent with previous studies showing the role of over-stimulation of the inflammatory response to SARS-CoV in pathogenesis. We conclude that the critical balance between immune response and inflammation can be manipulated to improve the outcome of the infection. Further, our study provides two potential therapeutic strategies for mitigating the effects of SARS-CoV infection, and may provide insight into treatment strategies for Middle East Respiratory Syndrome Coronavirus (MERS-CoV).

  12. Inhibition of severe acute respiratory syndrome coronavirus replication in a lethal SARS-CoV BALB/c mouse model by stinging nettle lectin, Urtica dioica agglutinin

    Science.gov (United States)

    Kumaki, Yohichi; Wandersee, Miles K.; Smith, Aaron J.; Zhou, Yanchen; Simmons, Graham; Nelson, Nathan M.; Bailey, Kevin W.; Vest, Zachary G.; Li, Joseph K.-K.; Chan, Paul Kay-Sheung; Smee, Donald F.; Barnard, Dale L.

    2011-01-01

    Urtica dioica agglutinin (UDA) is a small plant monomeric lectin, 8.7 kDa in size, with an N-acetylglucosamine specificity that inhibits viruses from Nidovirales in vitro. In the current study, we first examined the efficacy of UDA on the replication of different SARS-CoV strains in Vero 76 cells. UDA inhibited virus replication in a dose-dependent manner and reduced virus yields of the Urbani strain by 90% at 1.1 ± 0.4 µg/ml in Vero 76 cells. Then, UDA was tested for efficacy in a lethal SARS-CoV-infected BALB/c mouse model. BALB/c mice were infected with two LD50 (575 PFU) of virus for 4 hours before the mice were treated intraperitoneally with UDA at 20, 10, 5 or 0 mg/kg/day for 4 days. Treatment with UDA at 5 mg/kg significantly protected the mice against a lethal infection with mouse-adapted SARS-CoV (p<0.001), but did not significantly reduce virus lung titers. All virus-infected mice receiving UDA treatments were also significantly protected against weight loss (p<0.001). UDA also effectively reduced lung pathology scores. At day 6 after virus exposure, all groups of mice receiving UDA had much lower lung weights than did the placebo-treated mice. Thus, our data suggest that UDA treatment of SARS infection in mice leads to a substantial therapeutic effect that protects mice against death and weight loss. Furthermore, the mode of action of UDA in vitro was further investigated using live SARS-CoV Urbani strain virus and retroviral particles pseudotyped with SARS-CoV spike (S). UDA specifically inhibited the replication of live SARS-CoV or SARS-CoV pseudotyped virus when added just before, but not after, adsorption. These data suggested that UDA likely inhibits SARS-CoV infection by targeting early stages of the replication cycle, namely, adsorption or penetration. In addition, we demonstrated that UDA neutralizes the virus infectivity, presumably by binding to the SARS-CoV spike (S) glycoprotein. Finally, the target molecule for inhibition of virus

  13. Novel Polarimetric SAR Interferometry Algorithms, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Polarimetric radar interferometry (PolInSAR) is a new SAR imaging mode that is rapidly becoming an important technique for bare earth topographic mapping, tree...

  14. SAR Image Enhancement using Particle Filters

    Data.gov (United States)

    National Aeronautics and Space Administration — In this paper, we propose a novel approach to reduce the noise in Synthetic Aperture Radar (SAR) images using particle filters. Interpretation of SAR images is a...

  15. Inhibition of cytokine gene expression and induction of chemokine genes in non-lymphatic cells infected with SARS coronavirus

    Directory of Open Access Journals (Sweden)

    Weber Friedemann

    2006-03-01

    Full Text Available Abstract Background SARS coronavirus (SARS-CoV is the etiologic agent of the severe acute respiratory syndrome. SARS-CoV mainly infects tissues of non-lymphatic origin, and the cytokine profile of those cells can determine the course of disease. Here, we investigated the cytokine response of two human non-lymphatic cell lines, Caco-2 and HEK 293, which are fully permissive for SARS-CoV. Results A comparison with established cytokine-inducing viruses revealed that SARS-CoV only weakly triggered a cytokine response. In particular, SARS-CoV did not activate significant transcription of the interferons IFN-α, IFN-β, IFN-λ1, IFN-λ2/3, as well as of the interferon-induced antiviral genes ISG56 and MxA, the chemokine RANTES and the interleukine IL-6. Interestingly, however, SARS-CoV strongly induced the chemokines IP-10 and IL-8 in the colon carcinoma cell line Caco-2, but not in the embryonic kidney cell line 293. Conclusion Our data indicate that SARS-CoV suppresses the antiviral cytokine system of non-immune cells to a large extent, thus buying time for dissemination in the host. However, synthesis of IP-10 and IL-8, which are established markers for acute-stage SARS, escapes the virus-induced silencing at least in some cell types. Therefore, the progressive infiltration of immune cells into the infected lungs observed in SARS patients could be due to the production of these chemokines by the infected tissue cells.

  16. High-Dose Mannose-Binding Lectin Therapy for Ebola Virus Infection

    Science.gov (United States)

    2010-06-01

    viruses . N-glycosylation of viral envelopes is an important such target shared between in- fluenza, HIV, HCV, West Nile virus , SARS-CoV, Hendra virus ...host cells. Therefore, MBL preferentially recognizes glycosylated viruses including influenza virus , human immunodeficiency virus , severe acute...are heavily glycosylated and contain high-mannose. As a result, MBL binds to Ebola and Marburg viruses and mediates com- plement-dependent virus

  17. Imaging in severe acute respiratory syndrome (SARS)

    International Nuclear Information System (INIS)

    Antonio, G.E.; Wong, K.T.; Chu, W.C.W.; Hui, D.S.C.; Cheng, F.W.T.; Yuen, E.H.Y.; Chung, S.S.C.; Fok, T.F.; Sung, J.J.Y.; Ahuja, A.T.

    2003-01-01

    Severe acute respiratory syndrome (SARS) is a highly infectious disease caused by a novel coronavirus, and has become pandemic within a short period of time. Imaging plays an important role in the diagnosis, management and follow-up of patients with SARS. The current status of imaging in SARS is presented in this review

  18. SAR Systems and Related Signal Processing

    NARCIS (Netherlands)

    Hoogeboom, P.; Dekker, R.J.; Otten, M.P.G.

    1996-01-01

    Synthetic Aperture Radar (SAR) is today a valuable source of remote sensing information. SAR is a side-looking imaging radar and operates from airborne and spacebome platforms. Coverage, resolution and image quality are strongly influenced by the platform. SAR processing can be performed on standard

  19. Convolutional Neural Networks for SAR Image Segmentation

    DEFF Research Database (Denmark)

    Malmgren-Hansen, David; Nobel-Jørgensen, Morten

    2015-01-01

    Segmentation of Synthetic Aperture Radar (SAR) images has several uses, but it is a difficult task due to a number of properties related to SAR images. In this article we show how Convolutional Neural Networks (CNNs) can easily be trained for SAR image segmentation with good results. Besides...

  20. Modeling the structure of SARS 3a transmembrane protein using a ...

    Indian Academy of Sciences (India)

    Abstract. 3a is an accessory protein from SARS coronavirus that is known to play a significant role in the proliferation of the virus by forming tetrameric ion channels. Although the monomeric units are known to consist of three transmembrane (TM) domains, there are no solved structures available for the complete monomer.

  1. Polarimetric scattering and SAR information retrieval

    CERN Document Server

    Jin, Ya-Qiu

    2013-01-01

    Taking an innovative look at Synthetic Aperture Radar (SAR), this practical reference fully covers new developments in SAR and its various methodologies and enables readers to interpret SAR imagery An essential reference on polarimetric Synthetic Aperture Radar (SAR), this book uses scattering theory and radiative transfer theory as a basis for its treatment of topics. It is organized to include theoretical scattering models and SAR data analysis techniques, and presents cutting-edge research on theoretical modelling of terrain surface. The book includes quantitative app

  2. Stalking SARS: CDC at Work

    Centers for Disease Control (CDC) Podcasts

    2014-05-22

    In this podcast for kids, the Kidtastics talk about the SARS outbreak and how CDC worked to solve the mystery.  Created: 5/22/2014 by National Center for Immunization and Respiratory Diseases (NCIRD).   Date Released: 5/22/2014.

  3. Light weight digital array SAR

    NARCIS (Netherlands)

    Otten, M.; Maas, N.; Bolt, R.; Anitori, L.

    2010-01-01

    A light weight SAR has been designed, suitable for short range tactical UAVs, consisting of a fully digital receive array, and a very compact active transmit antenna. The weight of the complete RF front is expected to be below 3 kg, with a power consumption below 30 W. This X-band system can provide

  4. Topography estimation using SAR image polarimetry

    Science.gov (United States)

    Sabry, Ramin; Mattar, Karim E.

    2014-10-01

    Polarization orientation angle (POA) correction to compensate for terrain effects on polarimetric SAR data has been investigated in the literature. POA rotation can be derived from digital elevation model (DEM) and/or from polarimetric SAR (PolSAR) data through covariance/coherency analysis. A robust analytic model connecting PolSAR data and products (e.g., POA) to target/scene terrain characteristics can serve two main objectives. First is to correct and calibrate PolSAR data acquired from different SARs when DEM is available. Second is to model terrain through inverse solution of POAs derived from PolSAR data analysis. This formalism has been developed and is presented here. Effectiveness of the technique in providing both forward (POAs from DEM) and inverse (DEM from POAs) solutions is explored through imagery product examples and simulations.

  5. A model for the dynamic nuclear/nucleolar/cytoplasmic trafficking of the porcine reproductive and respiratory syndrome virus (PRRSV) nucleocapsid protein based on live cell imaging

    International Nuclear Information System (INIS)

    You, Jae-Hwan; Howell, Gareth; Pattnaik, Asit K.; Osorio, Fernando A.; Hiscox, Julian A.

    2008-01-01

    Porcine reproductive and respiratory syndrome virus (PRRSV), an arterivirus, in common with many other positive strand RNA viruses, encodes a nucleocapsid (N) protein which can localise not only to the cytoplasm but also to the nucleolus in virus-infected cells and cells over-expressing N protein. The dynamic trafficking of positive strand RNA virus nucleocapsid proteins and PRRSV N protein in particular between the cytoplasm and nucleolus is unknown. In this study live imaging of permissive and non-permissive cell lines, in conjunction with photo-bleaching (FRAP and FLIP), was used to investigate the trafficking of fluorescent labeled (EGFP) PRRSV-N protein. The data indicated that EGFP-PRRSV-N protein was not permanently sequestered to the nucleolus and had equivalent mobility to cellular nucleolar proteins. Further the nuclear import of N protein appeared to occur faster than nuclear export, which may account for the observed relative distribution of N protein between the cytoplasm and the nucleolus

  6. Yeast based small molecule screen for inhibitors of SARS-CoV.

    Directory of Open Access Journals (Sweden)

    Matthew Frieman

    Full Text Available Severe acute respiratory coronavirus (SARS-CoV emerged in 2002, resulting in roughly 8000 cases worldwide and 10% mortality. The animal reservoirs for SARS-CoV precursors still exist and the likelihood of future outbreaks in the human population is high. The SARS-CoV papain-like protease (PLP is an attractive target for pharmaceutical development because it is essential for virus replication and is conserved among human coronaviruses. A yeast-based assay was established for PLP activity that relies on the ability of PLP to induce a pronounced slow-growth phenotype when expressed in S. cerevisiae. Induction of the slow-growth phenotype was shown to take place over a 60-hour time course, providing the basis for conducting a screen for small molecules that restore growth by inhibiting the function of PLP. Five chemical suppressors of the slow-growth phenotype were identified from the 2000 member NIH Diversity Set library. One of these, NSC158362, potently inhibited SARS-CoV replication in cell culture without toxic effects on cells, and it specifically inhibited SARS-CoV replication but not influenza virus replication. The effect of NSC158362 on PLP protease, deubiquitinase and anti-interferon activities was investigated but the compound did not alter these activities. Another suppressor, NSC158011, demonstrated the ability to inhibit PLP protease activity in a cell-based assay. The identification of these inhibitors demonstrated a strong functional connection between the PLP-based yeast assay, the inhibitory compounds, and SARS-CoV biology. Furthermore the data with NSC158362 suggest a novel mechanism for inhibition of SARS-CoV replication that may involve an unknown activity of PLP, or alternatively a direct effect on a cellular target that modifies or bypasses PLP function in yeast and mammalian cells.

  7. Synthetic SAR Image Generation using Sensor, Terrain and Target Models

    DEFF Research Database (Denmark)

    Kusk, Anders; Abulaitijiang, Adili; Dall, Jørgen

    2016-01-01

    of the object using a CAD-model. The raw measurements are input to a SAR system and terrain model, which models thermal noise, terrain clutter, and SAR focusing to produce synthetic SAR images. Examples of SAR images at 0.3m and 0.1m resolution, and a comparison with real SAR imagery from the MSTAR dataset...

  8. SAR Image Complex Pixel Representations

    Energy Technology Data Exchange (ETDEWEB)

    Doerry, Armin W. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-03-01

    Complex pixel values for Synthetic Aperture Radar (SAR) images of uniform distributed clutter can be represented as either real/imaginary (also known as I/Q) values, or as Magnitude/Phase values. Generally, these component values are integers with limited number of bits. For clutter energy well below full-scale, Magnitude/Phase offers lower quantization noise than I/Q representation. Further improvement can be had with companding of the Magnitude value.

  9. Building Detection in SAR Imagery

    Energy Technology Data Exchange (ETDEWEB)

    Steinbach, Ryan Matthew [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Koch, Mark William [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Moya, Mary M [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Goold, Jeremy [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2014-08-01

    Current techniques for building detection in Synthetic Aperture Radar (SAR) imagery can be computationally expensive and/or enforce stringent requirements for data acquisition. The desire is to present a technique that is effective and efficient at determining an approximate building location. This approximate location can be used to extract a portion of the SAR image to then perform a more robust detection. The proposed technique assumes that for the desired image, bright lines and shadows, SAR artifact effects, are approximately labeled. These labels are enhanced and utilized to locate buildings, only if the related bright lines and shadows can be grouped. In order to find which of the bright lines and shadows are related, all of the bright lines are connected to all of the shadows. This allows the problem to be solved from a connected graph viewpoint. Where the nodes are the bright lines and shadows and the arcs are the connections between bright lines and shadows. Constraints based on angle of depression and the relationship between connected bright lines and shadows are applied to remove unrelated arcs. Once the related bright lines and shadows are grouped, their locations are combined to provide an approximate building location. Experimental results are provided showing the outcome of the technique.

  10. Forest biomass estimation from polarimetric SAR interferometry

    Energy Technology Data Exchange (ETDEWEB)

    Mette, T.

    2007-07-01

    Polarimetric SAR interferometry (Pol-InSAR) is a radar remote sensing technique that allows extracting forest heights by means of model-based inversions. Forest biomass is closely related to forest height, and can be derived from it with allometric relations. This work investigates the combination of the two methods to estimate forest biomass from Pol-InSAR. It develops a concept for the use of height-biomass allometry, and outlines the Pol-InSAR height inversion. The methodology is validated against a set of forest inventory data and Pol-InSAR data at L-band of the test site Traunstein. The results allow drawing conclusions on the potential of Pol-InSAR forest biomass missions. (orig.)

  11. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor.

    Science.gov (United States)

    Ge, Xing-Yi; Li, Jia-Lu; Yang, Xing-Lou; Chmura, Aleksei A; Zhu, Guangjian; Epstein, Jonathan H; Mazet, Jonna K; Hu, Ben; Zhang, Wei; Peng, Cheng; Zhang, Yu-Ji; Luo, Chu-Ming; Tan, Bing; Wang, Ning; Zhu, Yan; Crameri, Gary; Zhang, Shu-Yi; Wang, Lin-Fa; Daszak, Peter; Shi, Zheng-Li

    2013-11-28

    The 2002-3 pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV) was one of the most significant public health events in recent history. An ongoing outbreak of Middle East respiratory syndrome coronavirus suggests that this group of viruses remains a key threat and that their distribution is wider than previously recognized. Although bats have been suggested to be the natural reservoirs of both viruses, attempts to isolate the progenitor virus of SARS-CoV from bats have been unsuccessful. Diverse SARS-like coronaviruses (SL-CoVs) have now been reported from bats in China, Europe and Africa, but none is considered a direct progenitor of SARS-CoV because of their phylogenetic disparity from this virus and the inability of their spike proteins to use the SARS-CoV cellular receptor molecule, the human angiotensin converting enzyme II (ACE2). Here we report whole-genome sequences of two novel bat coronaviruses from Chinese horseshoe bats (family: Rhinolophidae) in Yunnan, China: RsSHC014 and Rs3367. These viruses are far more closely related to SARS-CoV than any previously identified bat coronaviruses, particularly in the receptor binding domain of the spike protein. Most importantly, we report the first recorded isolation of a live SL-CoV (bat SL-CoV-WIV1) from bat faecal samples in Vero E6 cells, which has typical coronavirus morphology, 99.9% sequence identity to Rs3367 and uses ACE2 from humans, civets and Chinese horseshoe bats for cell entry. Preliminary in vitro testing indicates that WIV1 also has a broad species tropism. Our results provide the strongest evidence to date that Chinese horseshoe bats are natural reservoirs of SARS-CoV, and that intermediate hosts may not be necessary for direct human infection by some bat SL-CoVs. They also highlight the importance of pathogen-discovery programs targeting high-risk wildlife groups in emerging disease hotspots as a strategy for pandemic preparedness.

  12. Precision Rectification of Airborne SAR Image

    DEFF Research Database (Denmark)

    Dall, Jørgen; Liao, M.; Zhang, Zhe

    1997-01-01

    A simple and direct procedure for the rectification of a certain class of airborne SAR data is presented. The relief displacements of SAR data are effectively removed by means of a digital elevation model and the image is transformed to the ground coordinate system. SAR data from the Danish EMISAR......([7]) is used. The EMISAR produces data with a geometrical resolution of 2.0 meters. The corrected image is tested against photogrammetric control measurements and an accuracy better than 0.5 pixel corresponding to 0.75 meters is obtained. The results indicate promising possibilities...... for the application of SAR data in the difficult process of map revision and updating....

  13. Bistatic SAR: Signal Processing and Image Formation.

    Energy Technology Data Exchange (ETDEWEB)

    Wahl, Daniel E.; Yocky, David A.

    2014-10-01

    This report describes the significant processing steps that were used to take the raw recorded digitized signals from the bistatic synthetic aperture RADAR (SAR) hardware built for the NCNS Bistatic SAR project to a final bistatic SAR image. In general, the process steps herein are applicable to bistatic SAR signals that include the direct-path signal and the reflected signal. The steps include preprocessing steps, data extraction to for a phase history, and finally, image format. Various plots and values will be shown at most steps to illustrate the processing for a bistatic COSMO SkyMed collection gathered on June 10, 2013 on Kirtland Air Force Base, New Mexico.

  14. Geometric calibration of ERS satellite SAR images

    DEFF Research Database (Denmark)

    Mohr, Johan Jacob; Madsen, Søren Nørvang

    2001-01-01

    Geometric calibration of the European Remote Sensing (ERS) Satellite synthetic aperture radar (SAR) slant range images is important in relation to mapping areas without ground reference points and also in relation to automated processing. The relevant SAR system parameters are discussed and calib......Geometric calibration of the European Remote Sensing (ERS) Satellite synthetic aperture radar (SAR) slant range images is important in relation to mapping areas without ground reference points and also in relation to automated processing. The relevant SAR system parameters are discussed...

  15. InfoTerra/TerraSAR initiative

    Science.gov (United States)

    Wahl, Manfred W.

    2004-01-01

    The overarching goal of the InfoTerra/TerraSAR Initiative is to establish a self-sustaining operational/commercial business built on Europe"s know-how and experience in space-borne Synthetic Aperture Radar (SAR) technology, in SAR data processing as well as in SAR applications. InfoTerra stands for a new business concept based on supplying innovative geo-information products and services. TerraSAR is a space and ground system conceived to consist of an initial deployment and operation of 2 Radar satellites (one in X- and one in L-band) flying in a tandem configuration in the same orbit. The design of TerraSAR is driven by the market and is user-oriented. TerraSAR is key to capturing a significant proportion of the existing market and to opening new market opportunities, when it becomes operational. The InfoTerra/TerraSAR Initiative has evolved gradually. It started in 1997 as a joint venture between German (DSS) and British (MMS-UK) space industry, strongly supported by both space agencies, DLR and BNSC. In early 2001, DLR and BNSC submitted to ESA the Formal Programme Proposal for InfoTerra/TerraSAR to become an essential element of ESA"s Earth Watch Programme. In summer 2001, when it became evident that there was not yet sufficient support from the ESA Member States to allow immediate start entering into TerraSAR Phase C/D, it has been decided to implement first a TerraSAR consolidation phase. In early 2002, in order to avoid further delays, a contract was signed between DLR and Astrium GmbH on the development of one component of TerraSAR, the TerraSAR-X, in the frame of a national programme, governed by a Public Private Partnership Agreement. Even if now the different launch dates for TerraSAR-X and TerraSAR-L are narrowing down the window of common data acquisition, it is a reasonable starting point, but it should always be kept in mind that the utmost goal for the longterm is to achieve self sustainability by supplying geo-information products and services

  16. Sentinel-3 SAR Altimetry Toolbox

    Science.gov (United States)

    Benveniste, Jerome; Lucas, Bruno; DInardo, Salvatore

    2015-04-01

    The prime objective of the SEOM (Scientific Exploitation of Operational Missions) element is to federate, support and expand the large international research community that the ERS, ENVISAT and the Envelope programmes have build up over the last 20 years for the future European operational Earth Observation missions, the Sentinels. Sentinel-3 builds directly on a proven heritage of ERS-2 and Envisat, and CryoSat-2, with a dual-frequency (Ku and C band) advanced Synthetic Aperture Radar Altimeter (SRAL) that provides measurements at a resolution of ~300m in SAR mode along track. Sentinel-3 will provide exact measurements of sea-surface height along with accurate topography measurements over sea ice, ice sheets, rivers and lakes. The first of the two Sentinels is expected to be launched in early 2015. The current universal altimetry toolbox is BRAT (Basic Radar Altimetry Toolbox) which can read all previous and current altimetry mission's data, but it does not have the capabilities to read the upcoming Sentinel-3 L1 and L2 products. ESA will endeavour to develop and supply this capability to support the users of the future Sentinel-3 SAR Altimetry Mission. BRAT is a collection of tools and tutorial documents designed to facilitate the processing of radar altimetry data. This project started in 2005 from the joint efforts of ESA (European Space Agency) and CNES (Centre National d'Etudes Spatiales), and it is freely available at http://earth.esa.int/brat. The tools enable users to interact with the most common altimetry data formats, the BratGUI is the front-end for the powerful command line tools that are part of the BRAT suite. BRAT can also be used in conjunction with Matlab/IDL (via reading routines) or in C/C++/Fortran via a programming API, allowing the user to obtain desired data, bypassing the data-formatting hassle. BRAT can be used simply to visualise data quickly, or to translate the data into other formats such as netCDF, ASCII text files, KML (Google Earth

  17. SAR change detection techniques and applications

    NARCIS (Netherlands)

    Dekker, R.J.

    2005-01-01

    ABSTRACT: Change detection, the comparison of remote sensing images from different moments in time, is an important technique in environmental earth observation and security. SAR change detection is useful when weather and light conditions are unfavourable. Five methods of SAR change detection are

  18. PHARUS: A C-band Airborne SAR

    NARCIS (Netherlands)

    Hoogeboom, P.; Koomen, P.J.; Pouwels, H.; Snoeij, P.

    1990-01-01

    In The Netherlands a plan to design aircraft and build a polarimetric C-band SAR system of a novel design, called PHARUS (PHased Array Universal SAR) is carried out by three institutes. These institutes are the Physics and Electronics Laboratory TNO in The Hague (prime contractor and project

  19. Real-time brute force SAR processing

    NARCIS (Netherlands)

    Vlothuizen, W.J.; Ditzel, M.

    2009-01-01

    This paper presents a brute force method to perform real-time SAR processing. The method has several advantages over traditional so-called fast SAR implementations, as it does not make any approximations to alleviate the processing burden. However, the method does allow efficient implementation on

  20. SAR/MTI on small airborne platforms

    NARCIS (Netherlands)

    Rossum, W.L. van; Vermeulen, B.C.B.

    2006-01-01

    A small SAR-MTI system is being developed at TNO, aimed at deployment on tactical UAV. The system makes use of modern front-end technology, to provide flexible SAR imaging and MTI modes. Major design goals are 50 kg weight, 500 W power consumption and 50 cm resolution in order to comply with typical

  1. SAR processing using SHARC signal processing systems

    Science.gov (United States)

    Huxtable, Barton D.; Jackson, Christopher R.; Skaron, Steve A.

    1998-09-01

    Synthetic aperture radar (SAR) is uniquely suited to help solve the Search and Rescue problem since it can be utilized either day or night and through both dense fog or thick cloud cover. Other papers in this session, and in this session in 1997, describe the various SAR image processing algorithms that are being developed and evaluated within the Search and Rescue Program. All of these approaches to using SAR data require substantial amounts of digital signal processing: for the SAR image formation, and possibly for the subsequent image processing. In recognition of the demanding processing that will be required for an operational Search and Rescue Data Processing System (SARDPS), NASA/Goddard Space Flight Center and NASA/Stennis Space Center are conducting a technology demonstration utilizing SHARC multi-chip modules from Boeing to perform SAR image formation processing.

  2. SARS: systematic review of treatment effects.

    Directory of Open Access Journals (Sweden)

    Lauren J Stockman

    2006-09-01

    Full Text Available BACKGROUND: The SARS outbreak of 2002-2003 presented clinicians with a new, life-threatening disease for which they had no experience in treating and no research on the effectiveness of treatment options. The World Health Organization (WHO expert panel on SARS treatment requested a systematic review and comprehensive summary of treatments used for SARS-infected patients in order to guide future treatment and identify priorities for research. METHODS AND FINDINGS: In response to the WHO request we conducted a systematic review of the published literature on ribavirin, corticosteroids, lopinavir and ritonavir (LPV/r, type I interferon (IFN, intravenous immunoglobulin (IVIG, and SARS convalescent plasma from both in vitro studies and in SARS patients. We also searched for clinical trial evidence of treatment for acute respiratory distress syndrome. Sources of data were the literature databases MEDLINE, EMBASE, BIOSIS, and the Cochrane Central Register of Controlled Trials (CENTRAL up to February 2005. Data from publications were extracted and evidence within studies was classified using predefined criteria. In total, 54 SARS treatment studies, 15 in vitro studies, and three acute respiratory distress syndrome studies met our inclusion criteria. Within in vitro studies, ribavirin, lopinavir, and type I IFN showed inhibition of SARS-CoV in tissue culture. In SARS-infected patient reports on ribavirin, 26 studies were classified as inconclusive, and four showed possible harm. Seven studies of convalescent plasma or IVIG, three of IFN type I, and two of LPV/r were inconclusive. In 29 studies of steroid use, 25 were inconclusive and four were classified as causing possible harm. CONCLUSIONS: Despite an extensive literature reporting on SARS treatments, it was not possible to determine whether treatments benefited patients during the SARS outbreak. Some may have been harmful. Clinical trials should be designed to validate a standard protocol for dosage

  3. Multiple alignment analysis on phylogenetic tree of the spread of SARS epidemic using distance method

    Science.gov (United States)

    Amiroch, S.; Pradana, M. S.; Irawan, M. I.; Mukhlash, I.

    2017-09-01

    Multiple Alignment (MA) is a particularly important tool for studying the viral genome and determine the evolutionary process of the specific virus. Application of MA in the case of the spread of the Severe acute respiratory syndrome (SARS) epidemic is an interesting thing because this virus epidemic a few years ago spread so quickly that medical attention in many countries. Although there has been a lot of software to process multiple sequences, but the use of pairwise alignment to process MA is very important to consider. In previous research, the alignment between the sequences to process MA algorithm, Super Pairwise Alignment, but in this study used a dynamic programming algorithm Needleman wunchs simulated in Matlab. From the analysis of MA obtained and stable region and unstable which indicates the position where the mutation occurs, the system network topology that produced the phylogenetic tree of the SARS epidemic distance method, and system area networks mutation.

  4. Processing PHARUS Data with the Generic SAR Processor

    NARCIS (Netherlands)

    Otten, M.P.G.

    1996-01-01

    The Generic SAR Processor (GSP) is a SAR processing environment created to process airborne and spaceborne SAR data with a maximum amount of flexibility, while at the same time providing a user friendly and powerful environment for handling and analyzing SAR, including polarimetric calibiation.

  5. Certainties and Uncertainties Facing Emerging Respiratory Infectious Diseases: Lessons from SARS

    Directory of Open Access Journals (Sweden)

    Yee-Chun Chen

    2008-06-01

    Full Text Available Every emerging infectious disease is a challenge to the whole of mankind. There are uncertainties regarding whether there will be a pandemic, if it will be caused by the highly pathogenic H5N1 influenza virus, when or where it will occur, how imminent or how severe it will be. No one can accurately predict if and when a given virus will become a pandemic virus. Pandemic prevention strategies must be based on preparing for the unexpected and being capable of reacting accordingly. There is growing evidence that infection control measures were helpful in containment of severe acute respiratory syndrome (SARS as well as avian influenza. Compliance of standard infection control measures, intensive promotion of hand and respiratory hygiene, vigilance and triage of patients with febrile illness, and specific infection control measures are key components to contain a highly contagious disease in hospital and to protect healthcare workers, patients and visitors. The importance of standard precautions for any patient and cleaning and disinfection for the healthcare environment cannot be overemphasized. SARS illustrated dramatically the potential of air travel and globalization for the dissemination of an emerging infectious disease. To prevent the potential serious consequences of pandemic influenza, timely implementation of pharmaceutical and non-pharmaceutical interventions locally within the outbreak area is the key to minimizing global spread. Herein, we relate our perspective on useful lessons derived from a review of the SARS epidemic that may be useful to physicians, especially when looking ahead to the next epidemic.

  6. Functional genomics highlights differential induction of antiviral pathways in the lungs of SARS-CoV-infected macaques.

    Directory of Open Access Journals (Sweden)

    Anna de Lang

    2007-08-01

    Full Text Available The pathogenesis of severe acute respiratory syndrome coronavirus (SARS-CoV is likely mediated by disproportional immune responses and the ability of the virus to circumvent innate immunity. Using functional genomics, we analyzed early host responses to SARS-CoV infection in the lungs of adolescent cynomolgus macaques (Macaca fascicularis that show lung pathology similar to that observed in human adults with SARS. Analysis of gene signatures revealed induction of a strong innate immune response characterized by the stimulation of various cytokine and chemokine genes, including interleukin (IL-6, IL-8, and IP-10, which corresponds to the host response seen in acute respiratory distress syndrome. As opposed to many in vitro experiments, SARS-CoV induced a wide range of type I interferons (IFNs and nuclear translocation of phosphorylated signal transducer and activator of transcription 1 in the lungs of macaques. Using immunohistochemistry, we revealed that these antiviral signaling pathways were differentially regulated in distinctive subsets of cells. Our studies emphasize that the induction of early IFN signaling may be critical to confer protection against SARS-CoV infection and highlight the strength of combining functional genomics with immunohistochemistry to further unravel the pathogenesis of SARS.

  7. LAND SUBSIDENCE MONITORING USING PS-InSAR TECHNIQUE FOR L-BAND SAR DATA

    Directory of Open Access Journals (Sweden)

    S. Thapa

    2016-10-01

    Full Text Available Differential SAR-Interferometry (D-InSAR is one of the potential source to measure land surface motion induced due to underground coal mining. However, this technique has many limitation such as atmospheric in homogeneities, spatial de-correlation, and temporal decorrelation. Persistent Scatterer Interferometry synthetic aperture radar (PS-InSAR belongs to a family of time series InSAR technique, which utilizes the properties of some of the stable natural and anthropogenic targets which remain coherent over long time period. In this study PS-InSAR technique has been used to monitor land subsidence over selected location of Jharia Coal field which has been correlated with the ground levelling measurement. This time series deformation observed using PS InSAR helped us to understand the nature of the ground surface deformation due to underground mining activity.

  8. Offshore wind mapping Mediterranean area using SAR

    DEFF Research Database (Denmark)

    Calaudi, Rosamaria; Arena, Felice; Badger, Merete

    2013-01-01

    Satellite observations of the ocean surface, for example from Synthetic Aperture Radars (SAR), provide information about the spatial wind variability over large areas. This is of special interest in the Mediterranean Sea, where spatial wind information is only provided by sparse buoys, often...... with long periods of missing data. Here, we focus on evaluating the use of SAR for offshore wind mapping. Preliminary results from the analysis of SAR-based ocean winds in Mediterranean areas show interesting large scale wind flow features consistent with results from previous studies using numerical models...

  9. Primary studies of Chinese spaceborne SAR

    Science.gov (United States)

    Wang, Zhen-Song; Wu, Guo-Xiang; Guo, Hua-Dong; Wei, Zhong-Quan; Zhu, Min-Hui

    1993-01-01

    The primary studies on spaceborne synthetic aperture radar (SAR) in China are discussed. The SAR will be launched aboard a Chinese satellite and operated at L-band with HH polarization. The purpose of the mission in consideration is dedicated to resources and environment uses, especially to natural disaster monitoring. The ground resolution is designed as 25 m x 25 m for detailed mode and 100 m x 100 m for wide scan-SAR mode. The off-nadir angle can be varied from 20 to 40 deg. The key system concepts are introduced.

  10. Differential sensitivity of bat cells to infection by enveloped RNA viruses: coronaviruses, paramyxoviruses, filoviruses, and influenza viruses.

    Directory of Open Access Journals (Sweden)

    Markus Hoffmann

    Full Text Available Bats (Chiroptera host major human pathogenic viruses including corona-, paramyxo, rhabdo- and filoviruses. We analyzed six different cell lines from either Yinpterochiroptera (including African flying foxes and a rhinolophid bat or Yangochiroptera (genera Carollia and Tadarida for susceptibility to infection by different enveloped RNA viruses. None of the cells were sensitive to infection by transmissible gastroenteritis virus (TGEV, a porcine coronavirus, or to infection mediated by the Spike (S protein of SARS-coronavirus (SARS-CoV incorporated into pseudotypes based on vesicular stomatitis virus (VSV. The resistance to infection was overcome if cells were transfected to express the respective cellular receptor, porcine aminopeptidase N for TGEV or angiotensin-converting enzyme 2 for SARS-CoV. VSV pseudotypes containing the S proteins of two bat SARS-related CoV (Bg08 and Rp3 were unable to infect any of the six tested bat cell lines. By contrast, viral pseudotypes containing the surface protein GP of Marburg virus from the family Filoviridae infected all six cell lines though at different efficiency. Notably, all cells were sensitive to infection by two paramyxoviruses (Sendai virus and bovine respiratory syncytial virus and three influenza viruses from different subtypes. These results indicate that bat cells are more resistant to infection by coronaviruses than to infection by paramyxoviruses, filoviruses and influenza viruses. Furthermore, these results show a receptor-dependent restriction of the infection of bat cells by CoV. The implications for the isolation of coronaviruses from bats are discussed.

  11. A novel monoclonal antibody specific to the C-terminal tail of the gap envelope transmembrane protein of human immunodeficiency virus type 1 that preferentially neutralizes virus after it has attached to the target cell and inhibits the production of infectious progeny

    International Nuclear Information System (INIS)

    Reading, Steven A; Heap, Caroline J; Dimmock, Nigel J.

    2003-01-01

    SAR1 is a new IgG2a murine monoclonal antibody derived by immunization with a plant virus expressing the sequence GERDRDR from the C-terminal tail of the gp41 transmembrane glycoprotein of human immunodeficiency virus type 1 (HIV-1). SAR1 binds to peptides and proteins carrying the GERDRDR sequence, to some but not all preparations of purified virus, and to cells infected with all viruses tested. In a standard neutralization assay, SAR1 failed to neutralize, or neutralized poorly, a number of T cell line-adapted viruses. However, it was more effective at postattachment neutralization. This was measured by two assays, the inhibition of the syncytium production by input virus, and the inhibition of the production of infectious progeny virus. In general SAR1 was more effective at neutralizing progeny virus than inoculum virus. Fifty percent inhibition of progeny virus production by different HIV-1 strains was obtained with 2-26 μg/ml of SAR1. The SAR1 neutralizing epitope was mapped specifically to the gp41 C-terminal tail. SAR1 is an unusual, if not unique, antibody whose activity supports the view that part of the gp41 C-terminal tail is exposed on the outside of the virion

  12. Generation of Recombinant Schmallenberg Virus Nucleocapsid Protein in Yeast and Development of Virus-Specific Monoclonal Antibodies

    Directory of Open Access Journals (Sweden)

    Justas Lazutka

    2014-01-01

    Full Text Available Schmallenberg virus (SBV, discovered in continental Europe in late 2011, causes mild clinical signs in adult ruminants, including diarrhoea and reduced milk yield. However, fetal infection can lead to severe malformation in newborn offspring. To develop improved reagents for SBV serology, a high-level yeast expression system was employed to produce recombinant SBV nucleocapsid (N protein. Recombinant SBV N protein was investigated as an antigen in SBV-specific IgG enzyme immunoassay and used for generation of monoclonal antibodies (MAbs. Yeast-expressed SBV N protein was reactive with anti-SBV IgG-positive cow serum specimens collected from different farms of Lithuania. After immunization of mice with recombinant SBV N protein, four MAbs were generated. The MAbs raised against recombinant SBV N protein reacted with native viral nucleocapsids in SBV-infected BHK cells by immunofluorescence assay. The reactivity of recombinant N protein with SBV-positive cow serum specimens and the ability of the MAbs to recognize virus-infected cells confirm the antigenic similarity between yeast-expressed SBV N protein and native viral nucleocapsids. Our study demonstrates that yeast expression system is suitable for high-level production of recombinant SBV N protein and provides the first evidence on the presence of SBV-specific antibodies in cow serum specimens collected in Lithuania.

  13. AUTOMATIC INTERPRETATION OF HIGH RESOLUTION SAR IMAGES: FIRST RESULTS OF SAR IMAGE SIMULATION FOR SINGLE BUILDINGS

    Directory of Open Access Journals (Sweden)

    J. Tao

    2012-09-01

    Full Text Available Due to the all-weather data acquisition capabilities, high resolution space borne Synthetic Aperture Radar (SAR plays an important role in remote sensing applications like change detection. However, because of the complex geometric mapping of buildings in urban areas, SAR images are often hard to interpret. SAR simulation techniques ease the visual interpretation of SAR images, while fully automatic interpretation is still a challenge. This paper presents a method for supporting the interpretation of high resolution SAR images with simulated radar images using a LiDAR digital surface model (DSM. Line features are extracted from the simulated and real SAR images and used for matching. A single building model is generated from the DSM and used for building recognition in the SAR image. An application for the concept is presented for the city centre of Munich where the comparison of the simulation to the TerraSAR-X data shows a good similarity. Based on the result of simulation and matching, special features (e.g. like double bounce lines, shadow areas etc. can be automatically indicated in SAR image.

  14. Work session on the SAR. Pt. 2

    International Nuclear Information System (INIS)

    Burkart, K.

    1980-01-01

    The present paper contains the tables of the contribution of K. Burkart 'Work Session on the SAR' to the IAEA Interregional Training Course held in Sept/Oct. 1980 at the Kernforschungszentrum Karlsruhe. (RW)

  15. Image based SAR product simulation for analysis

    Science.gov (United States)

    Domik, G.; Leberl, F.

    1987-01-01

    SAR product simulation serves to predict SAR image gray values for various flight paths. Input typically consists of a digital elevation model and backscatter curves. A new method is described of product simulation that employs also a real SAR input image for image simulation. This can be denoted as 'image-based simulation'. Different methods to perform this SAR prediction are presented and advantages and disadvantages discussed. Ascending and descending orbit images from NASA's SIR-B experiment were used for verification of the concept: input images from ascending orbits were converted into images from a descending orbit; the results are compared to the available real imagery to verify that the prediction technique produces meaningful image data.

  16. SARS Patients and Their Close Contacts

    Science.gov (United States)

    ... Guidance for Airline Personnel Guidance on Air Medical Transport for SARS Patients Legal Authorities for Isolation and ... g., bus, taxi). Do not go to work, school, out-of-home child care, church, or activities ...

  17. Satellite sar detection of hurricane helene (2006)

    DEFF Research Database (Denmark)

    Ju, Lian; Cheng, Yongcun; Xu, Qing

    2013-01-01

    In this paper, the wind structure of hurricane Helene (2006) over the Atlantic Ocean is investigated from a C-band RADARSAT-1 synthetic aperture radar (SAR) image acquired on 20 September 2006. First, the characteristics, e.g., the center, scale and area of the hurricane eye (HE) are determined....... There is a good agreement between the SAR-estimated HE center location and the best track data from the National Hurricane Center. The wind speeds at 10 m above the ocean surface are also retrieved from the SAR data using the geophysical model function (GMF), CMOD5, and compared with in situ wind speed...... observations from the stepped frequency microwave radiometer (SFMR) on NOAA P3 aircraft. All the results show the capability of hurricane monitoring by satellite SAR. Copyright © 2013 by the International Society of Offshore and Polar Engineers (ISOPE)....

  18. Small Sar Satellite Using Small Standard Bus

    OpenAIRE

    Ono, Kiyonobu; Fujimura, Takashi; Ogawa, Toshiaki; Kimura, Tsunekazu

    2011-01-01

    This paper introduces a new small SAR (Synthetic Aperture Radar) satellite that follows the small optical sensor satellite, ASNARO. USEF, NEDO and NEC are developing ASNARO satellite, which is a small LEO satellite (total mass

  19. MiTAP for SARS Detection

    National Research Council Canada - National Science Library

    Damianos, Laurie E; Bayer, Samuel; Chisholm, Michael A; Henderson, John; Hirschman, Lynette; Morgan, William; Ubaldino, Marc; Zarrella, Guido; Wilson, V, James M; Polyak, Marat G

    2006-01-01

    The MiTAP prototype for SARS detection uses human language technology for detecting, monitoring, and analyzing potential indicators of infectious disease outbreaks and reasoning for issuing warnings and alerts...

  20. Attribute Learning for SAR Image Classification

    Directory of Open Access Journals (Sweden)

    Chu He

    2017-04-01

    Full Text Available This paper presents a classification approach based on attribute learning for high spatial resolution Synthetic Aperture Radar (SAR images. To explore the representative and discriminative attributes of SAR images, first, an iterative unsupervised algorithm is designed to cluster in the low-level feature space, where the maximum edge response and the ratio of mean-to-variance are included; a cross-validation step is applied to prevent overfitting. Second, the most discriminative clustering centers are sorted out to construct an attribute dictionary. By resorting to the attribute dictionary, a representation vector describing certain categories in the SAR image can be generated, which in turn is used to perform the classifying task. The experiments conducted on TerraSAR-X images indicate that those learned attributes have strong visual semantics, which are characterized by bright and dark spots, stripes, or their combinations. The classification method based on these learned attributes achieves better results.

  1. Multiple Input - Multiple Output (MIMO) SAR

    Data.gov (United States)

    National Aeronautics and Space Administration — This effort will research and implement advanced Multiple-Input Multiple-Output (MIMO) Synthetic Aperture Radar (SAR) techniques which have the potential to improve...

  2. Simultaneous Navigation and SAR Auto-Focusing

    OpenAIRE

    Sjanic, Zoran; Gustafsson, Fredrik

    2010-01-01

    Synthetic Aperture Radar (SAR) equipment is an all-weather radar imaging system that can create high resolution images by means of utilising the movement of the flying platform. Accurate knowledge of the flown trajectory is essential in order to get focused images. Recently SAR systems are becoming more used on smaller and cheaper flying platforms like Unmanned Aerial Vehicles (UAV). Since UAVs in general have navigation systems with poorer performance than manned aircraft, the resulting images ...

  3. Wave directional spectrum from SAR imagery

    Digital Repository Service at National Institute of Oceanography (India)

    Fernandes, A.A.; Sarma, Y.V.B.; Menon, H.B.; Vethamony, P.

    with radar imagery. 1. SAR Measurements Digital ERS-1 image mode SAR scenes off Goa, Paradeep and Visakhapatnam were acquired from the National Remote Sensing Agency (NRSA), Hyderabad, India, with the intention of studying the spatial evolution... density and wave direction separately as a function of frequency using the digital band, pass filtering method, the buoy observation at 1050 IST showed (Table 1) that there were two main spectral peaks, both due to "swell" ( waves generated by distant...

  4. SARS: Key factors in crisis management.

    Science.gov (United States)

    Tseng, Hsin-Chao; Chen, Thai-Form; Chou, Shieu-Ming

    2005-03-01

    This study was conducted at a single hospital selected in Taipei during the SARS (Severe Acute Respiratory Syndrome) outbreak from March to July, 2003 in Taiwan. During this period of time, 104 SARS patients were admitted to the hospital. There were no negative reports related to the selected hospital despite its being located right in the center of an area struck by the epidemic. The purpose of this study was to identify the key factors enabling the hospital to survive SARS unscathed. Data were collected from in-depth interviews with the nursing directors and nursing managers of the SARS units, along with a review of relevant hospital documents. The five key elements identified as survival factors during this SARS crisis are as follows: 1. good control of timing for crisis management, 2. careful decision-making, 3. thorough implementation, 4. effective communication, and 5. trust between management and employees. The results of this study reconfirmed the selected hospital as a model for good crisis management during the SARS epidemic.

  5. SARS-coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulum.

    Directory of Open Access Journals (Sweden)

    Kèvin Knoops

    2008-09-01

    Full Text Available Positive-strand RNA viruses, a large group including human pathogens such as SARS-coronavirus (SARS-CoV, replicate in the cytoplasm of infected host cells. Their replication complexes are commonly associated with modified host cell membranes. Membrane structures supporting viral RNA synthesis range from distinct spherular membrane invaginations to more elaborate webs of packed membranes and vesicles. Generally, their ultrastructure, morphogenesis, and exact role in viral replication remain to be defined. Poorly characterized double-membrane vesicles (DMVs were previously implicated in SARS-CoV RNA synthesis. We have now applied electron tomography of cryofixed infected cells for the three-dimensional imaging of coronavirus-induced membrane alterations at high resolution. Our analysis defines a unique reticulovesicular network of modified endoplasmic reticulum that integrates convoluted membranes, numerous interconnected DMVs (diameter 200-300 nm, and "vesicle packets" apparently arising from DMV merger. The convoluted membranes were most abundantly immunolabeled for viral replicase subunits. However, double-stranded RNA, presumably revealing the site of viral RNA synthesis, mainly localized to the DMV interior. Since we could not discern a connection between DMV interior and cytosol, our analysis raises several questions about the mechanism of DMV formation and the actual site of SARS-CoV RNA synthesis. Our data document the extensive virus-induced reorganization of host cell membranes into a network that is used to organize viral replication and possibly hide replicating RNA from antiviral defense mechanisms. Together with biochemical studies of the viral enzyme complex, our ultrastructural description of this "replication network" will aid to further dissect the early stages of the coronavirus life cycle and its virus-host interactions.

  6. Synthetic SAR Image Generation using Sensor, Terrain and Target Models

    DEFF Research Database (Denmark)

    Kusk, Anders; Abulaitijiang, Adili; Dall, Jørgen

    2016-01-01

    A tool to generate synthetic SAR images of objects set on a clutter background is described. The purpose is to generate images for training Automatic Target Recognition and Identification algorithms. The tool employs a commercial electromagnetic simulation program to calculate radar cross sections...... of the object using a CAD-model. The raw measurements are input to a SAR system and terrain model, which models thermal noise, terrain clutter, and SAR focusing to produce synthetic SAR images. Examples of SAR images at 0.3m and 0.1m resolution, and a comparison with real SAR imagery from the MSTAR dataset...

  7. Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets

    NARCIS (Netherlands)

    ter Meulen, Jan; Bakker, Alexander B. H.; van den Brink, Edward N.; Weverling, Gerrit J.; Martina, Byron E. E.; Haagmans, Bart L.; Kuiken, Thijs; de Kruif, John; Preiser, Wolfgang; Spaan, Willy; Gelderblom, Hans R.; Goudsmit, Jaap; Osterhaus, Albert D. M. E.

    2004-01-01

    SARS coronavirus continues to cause sporadic cases of severe acute respiratory syndrome (SARS) in China. No active or passive immunoprophylaxis for disease induced by SARS coronavirus is available. We investigated prophylaxis of SARS coronavirus infection with a neutralising human monoclonal

  8. Use of SAR data for proliferation monitoring

    International Nuclear Information System (INIS)

    Lafitte, M.; Robin, J.P.

    2013-01-01

    Synthetic Aperture Radar (SAR) is an active and coherent system. SAR images are complex data which contain both amplitude and phase information. The analysis of single SAR data required a very good experience and a good understanding of SAR geometry regarding layover, shadowing, texture and speckle. Image analyst can depicts and describes most of the facilities related to nuclear proliferation and weapons of mass destruction (WMD). The Amplitude Change Detection (ACD) technique consists of a combination of two or three SAR amplitude data acquired with similar orbit and frequency parameters on different dates. That technique provides a very good overview of the changes and particularly regarding vehicles activity and constructions ongoing within the area of interest over the monitoring period. One of the particularities of the SAR systems is to be coherent. The phase of a single image is not exploitable. Thus when two or more SAR data have been acquired with identical orbit and frequency parameters, the phases shift are indicators of changes such as structural changes, terrain subsidence or motion. The Multi-Temporal Coherence (MTC) product merged the two type of information previously detailed: the ACD and coherence analysis. It consists of the combination of two amplitude images and the corresponding coherence computed image. The MTC image may highlights changes between two states of a target which on the ACD analysis appeared unchanged. EUSC uses the difference interferometry techniques in order to estimate volumes that have changed between two acquisition dates. The paper is followed by the slides of the presentation. (A.C.)

  9. Induction of Th1 type response by DNA vaccinations with N, M, and E genes against SARS-CoV in mice

    International Nuclear Information System (INIS)

    Jin Huali; Xiao Chong; Chen Ze; Kang Youmin; Ma Yijie; Zhu Kaichun; Xie Qifa; Tu Yixian; Yu Yang; Wang Bin

    2005-01-01

    Vaccination against the SARS-CoV infection is an attractive means to control the spread of viruses in public. In this study, we employed a DNA vaccine technology with the levamisole, our newly discovered chemical adjuvant, to generate Th1 type of response. To avoid the enhancement antibody issue, genes encoding the nucleocapsid, membrane, and envelope protein of SARS-CoV were cloned and their expressions in mammalian cells were determined. After the intramuscular introduction into animals, we observed that the constructs of the E, M, and N genes could induce high levels of specific antibodies, T cell proliferations, IFN-γ, DTH responses, and in vivo cytotoxic T cells activities specifically against SARS-CoV antigens. The highest immune responses were generated by the construct encoding the nucleocapsid protein. The results suggest that the N, M, and E genes could be used as the targets to prevent SARS-CoV infection in the DNA vaccine development

  10. Synthesis of human parainfluenza virus 4 nucleocapsid-like particles in yeast and their use for detection of virus-specific antibodies in human serum.

    Science.gov (United States)

    Bulavaitė, Aistė; Lasickienė, Rita; Tamošiūnas, Paulius Lukas; Simanavičius, Martynas; Sasnauskas, Kęstutis; Žvirblienė, Aurelija

    2017-04-01

    The aim of this study was to produce human parainfluenza virus type 4 (HPIV4) nucleocapsid (N) protein in yeast Saccharomyces cerevisiae expression system, to explore its structural and antigenic properties and to evaluate its applicability in serology. The use of an optimized gene encoding HPIV4 N protein amino acid (aa) sequence GenBank AGU90031.1 allowed high yield of recombinant N protein forming nucleocapsid-like particles (NLPs) in yeast. A substitution L332D disrupted self-assembly of NLPs, confirming the role of this position in the N proteins of Paramyxovirinae. Three monoclonal antibodies (MAbs) were generated against the NLP-forming HPIV4 N protein. They recognised HPIV4-infected cells, demonstrating the antigenic similarity between the recombinant and virus-derived N proteins. HPIV4 N protein was used as a coating antigen in an indirect IgG ELISA with serum specimens of 154 patients with respiratory tract infection. The same serum specimens were tested with previously generated N protein of a closely related HPIV2, another representative of genus Rubulavirus. Competitive ELISA was developed using related yeast-produced viral antigens to deplete the cross-reactive serum antibodies. In the ELISA either without or with competition using heterologous HPIV (2 or 4) N or mumps virus N proteins, the seroprevalence of HPIV4 N-specific IgG was, respectively, 46.8, 39.6 and 40.3% and the seroprevalence of HPIV2 N-specific IgG-47.4, 39.0 and 37.7%. In conclusion, yeast-produced HPIV4 N protein shares structural and antigenic properties of the native virus nucleocapsids. Yeast-produced HPIV4 and HPIV2 NLPs are prospective tools in serology.

  11. The nonstructural protein 8 (nsp8) of the SARS coronavirus interacts with its ORF6 accessory protein

    International Nuclear Information System (INIS)

    Kumar, Purnima; Gunalan, Vithiagaran; Liu Boping; Chow, Vincent T.K.; Druce, Julian; Birch, Chris; Catton, Mike; Fielding, Burtram C.; Tan, Yee-Joo; Lal, Sunil K.

    2007-01-01

    Severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) caused a severe outbreak in several regions of the world in 2003. The SARS-CoV genome is predicted to contain 14 functional open reading frames (ORFs). The first ORF (1a and 1b) encodes a large polyprotein that is cleaved into nonstructural proteins (nsp). The other ORFs encode for four structural proteins (spike, membrane, nucleocapsid and envelope) as well as eight SARS-CoV-specific accessory proteins (3a, 3b, 6, 7a, 7b, 8a, 8b and 9b). In this report we have cloned the predicted nsp8 gene and the ORF6 gene of the SARS-CoV and studied their abilities to interact with each other. We expressed the two proteins as fusion proteins in the yeast two-hybrid system to demonstrate protein-protein interactions and tested the same using a yeast genetic cross. Further the strength of the interaction was measured by challenging growth of the positive interaction clones on increasing gradients of 2-amino trizole. The interaction was then verified by expressing both proteins separately in-vitro in a coupled-transcription translation system and by coimmunoprecipitation in mammalian cells. Finally, colocalization experiments were performed in SARS-CoV infected Vero E6 mammalian cells to confirm the nsp8-ORF6 interaction. To the best of our knowledge, this is the first report of the interaction between a SARS-CoV accessory protein and nsp8 and our findings suggest that ORF6 protein may play a role in virus replication

  12. An improved MIMO-SAR simulator strategy with ray tracing

    Science.gov (United States)

    Xiang, Xingyu; Mo, Zijian; Wang, Zhonghai; Chen, Genshe; Pham, Khanh; Blasch, Erik

    2016-05-01

    High resolution and wide-swath imaging can be obtained by Multiple-Input Multiple-Output (MIMO) synthetic aperture radar (SAR) with the state of the art technologies. The time division multiple access (TDMA) MIMO SAR mimics the motion of the antenna of SAR systems by switching the array channels to transmit the radar signals at different time slots. In this paper, we develop a simulation tool with ray tracing techniques to retrieve high resolution and accurate SAR images for development of MIMO SAR imaging methods. Without loss of generality, in the proposed simulator, we apply a TDMA MIMO SAR system with 13 transmitting antennas and 8 receiving antennas, where all transmitting antennas share a single transmitter and the receiving antennas share a single receiver. By comparing with the normal simulation MIMO SAR strategies, the simulation image using ray tracing results validate that the proposed method provides more accurate and higher resolution SAR images.

  13. Accelerated Scientific InSAR Processing, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Neva Ridge Technologies proposes to develop a suite of software tools for the analysis of SAR and InSAR data, focused on having a robust and adopted capability well...

  14. Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research.

    Science.gov (United States)

    Simmons, Graham; Zmora, Pawel; Gierer, Stefanie; Heurich, Adeline; Pöhlmann, Stefan

    2013-12-01

    The severe acute respiratory syndrome (SARS) pandemic revealed that zoonotic transmission of animal coronaviruses (CoV) to humans poses a significant threat to public health and warrants surveillance and the development of countermeasures. The activity of host cell proteases, which cleave and activate the SARS-CoV spike (S) protein, is essential for viral infectivity and constitutes a target for intervention. However, the identities of the proteases involved have been unclear. Pioneer studies identified cathepsins and type II transmembrane serine proteases as cellular activators of SARS-CoV and demonstrated that several emerging viruses might exploit these enzymes to promote their spread. Here, we will review the proteolytic systems hijacked by SARS-CoV for S protein activation, we will discuss their contribution to viral spread in the host and we will outline antiviral strategies targeting these enzymes. This paper forms part of a series of invited articles in Antiviral Research on "From SARS to MERS: 10years of research on highly pathogenic human coronaviruses.'' Copyright © 2013 Elsevier B.V. All rights reserved.

  15. Stop outbreak of SARS with infrared cameras

    Science.gov (United States)

    Wu, Yigang M.

    2004-04-01

    SARS (Severe Acute Respiratory Syndrome, commonly known as Atypical Pneumonia in mainland China) caused 8422 people affected and resulting in 918 deaths worldwide in half year. This disease can be transmitted by respiratory droplets or by contact with a patient's respiratory secretions. This means it can be spread out very rapidly through the public transportations by the travelers with the syndrome. The challenge was to stop the SARS carriers traveling around by trains, airplanes, coaches and etc. It is impractical with traditional oral thermometers or spot infrared thermometers to screen the tens of travelers with elevated body temperature from thousands of normal travelers in hours. The thermal imager with temperature measurement function is a logical choice for this special application although there are some limitations and drawbacks. This paper discusses the real SARS applications of industrial infrared cameras in China from April to July 2003.

  16. Infrastructure monitoring with spaceborne SAR sensors

    CERN Document Server

    ANGHEL, ANDREI; CACOVEANU, REMUS

    2017-01-01

    This book presents a novel non-intrusive infrastructure monitoring technique based on the detection and tracking of scattering centers in spaceborne SAR images. The methodology essentially consists of refocusing each available SAR image on an imposed 3D point cloud associated to the envisaged infrastructure element and identifying the reliable scatterers to be monitored by means of four dimensional (4D) tomography. The methodology described in this book provides a new perspective on infrastructure monitoring with spaceborne SAR images, is based on a standalone processing chain, and brings innovative technical aspects relative to conventional approaches. The book is intended primarily for professionals and researchers working in the area of critical infrastructure monitoring by radar remote sensing.

  17. SARS-coronavirus replication/transcription complexes are membrane-protected and need a host factor for activity in vitro.

    Directory of Open Access Journals (Sweden)

    Martijn J van Hemert

    2008-05-01

    Full Text Available SARS-coronavirus (SARS-CoV replication and transcription are mediated by a replication/transcription complex (RTC of which virus-encoded, non-structural proteins (nsps are the primary constituents. The 16 SARS-CoV nsps are produced by autoprocessing of two large precursor polyproteins. The RTC is believed to be associated with characteristic virus-induced double-membrane structures in the cytoplasm of SARS-CoV-infected cells. To investigate the link between these structures and viral RNA synthesis, and to dissect RTC organization and function, we isolated active RTCs from infected cells and used them to develop the first robust assay for their in vitro activity. The synthesis of genomic RNA and all eight subgenomic mRNAs was faithfully reproduced by the RTC in this in vitro system. Mainly positive-strand RNAs were synthesized and protein synthesis was not required for RTC activity in vitro. All RTC activity, enzymatic and putative membrane-spanning nsps, and viral RNA cosedimented with heavy membrane structures. Furthermore, the pelleted RTC required the addition of a cytoplasmic host factor for reconstitution of its in vitro activity. Newly synthesized subgenomic RNA appeared to be released, while genomic RNA remained predominantly associated with the RTC-containing fraction. RTC activity was destroyed by detergent treatment, suggesting an important role for membranes. The RTC appeared to be protected by membranes, as newly synthesized viral RNA and several replicase/transcriptase subunits were protease- and nuclease-resistant and became susceptible to degradation only upon addition of a non-ionic detergent. Our data establish a vital functional dependence of SARS-CoV RNA synthesis on virus-induced membrane structures.

  18. Bistatic SAR: State of the Art and Development Trend

    OpenAIRE

    Zeng Tao

    2012-01-01

    Bistatic SAR (BiSAR) systems have attracted the interests from global researchers and become a hotspot in the international radar community due to the progress of radar technology and rapidly increased applications nowadays. Based on the BiSAR experiments and breakthrough of the key technology, the paper summarized the general progresses of BiSAR systems, especially in European radar community, from different aspects such as system design, processing idea and topology etc. Different bistatic ...

  19. Monitoring Building Deformation with InSAR: Experiments and Validation

    OpenAIRE

    Kui Yang; Li Yan; Guoman Huang; Chu Chen; Zhengpeng Wu

    2016-01-01

    Synthetic Aperture Radar Interferometry (InSAR) techniques are increasingly applied for monitoring land subsidence. The advantages of InSAR include high accuracy and the ability to cover large areas; nevertheless, research validating the use of InSAR on building deformation is limited. In this paper, we test the monitoring capability of the InSAR in experiments using two landmark buildings; the Bohai Building and the China Theater, located in Tianjin, China. They were selected as real example...

  20. Applications of SAR Interferometry in Earth and Environmental Science Research

    OpenAIRE

    Zhou, Xiaobing; Chang, Ni-Bin; Li, Shusun

    2009-01-01

    This paper provides a review of the progress in regard to the InSAR remote sensing technique and its applications in earth and environmental sciences, especially in the past decade. Basic principles, factors, limits, InSAR sensors, available software packages for the generation of InSAR interferograms were summarized to support future applications. Emphasis was placed on the applications of InSAR in seismology, volcanology, land subsidence/uplift, landslide, glaciology, hydrology, and forestr...

  1. SAR measurement in MRI: an improved method

    Science.gov (United States)

    Romano, Rocco; Acernese, Fausto; Indovina, Pietro Luigi; Barone, Fabrizio

    2009-03-01

    During an MR procedure, the patient absorbs a portion of the transmitted RF energy, which may result in tissue heating and other adverse effects, such as alterations in visual, auditory and neural functions. The Specific Absorption Rate (SAR), in W/kg, is the RF power absorbed per unit mass of tissue and is one of the most important parameters related with thermal effects and acts as a guideline for MRI safety. Strict limits to the SAR levels are imposed by patient safety international regulations (CEI - EN 60601 - 2 - 33) and SAR measurements are required in order to verify its respect. The recommended methods for mean SAR measurement are quite problematic and often require a maintenance man intervention and long stop machine. For example, in the CEI recommended pulse energy method, the presence of a maintenance man is required in order to correctly connect the required instrumentation; furthermore, the procedure is complex and requires remarkable processing and calculus. Simpler are the calorimetric methods, also if in this case long acquisition times are required in order to have significant temperature variations and accurate heat capacity knowledge (CEI - EN 60601 - 2- 33). The phase transition method is a new method to measure SAR in MRI which has the advantages to be very simple and to overcome all the typical calorimetric method problems. It does not require in gantry temperature measurements, any specific heat or heat capacity knowledge, but only mass and time measurement. Furthermore, in this method, it is possible to show that all deposited SAR power can be considered acquired and measured.

  2. The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors.

    Directory of Open Access Journals (Sweden)

    Susanne Pfefferle

    2011-10-01

    Full Text Available Coronaviruses (CoVs are important human and animal pathogens that induce fatal respiratory, gastrointestinal and neurological disease. The outbreak of the severe acute respiratory syndrome (SARS in 2002/2003 has demonstrated human vulnerability to (Coronavirus CoV epidemics. Neither vaccines nor therapeutics are available against human and animal CoVs. Knowledge of host cell proteins that take part in pivotal virus-host interactions could define broad-spectrum antiviral targets. In this study, we used a systems biology approach employing a genome-wide yeast-two hybrid interaction screen to identify immunopilins (PPIA, PPIB, PPIH, PPIG, FKBP1A, FKBP1B as interaction partners of the CoV non-structural protein 1 (Nsp1. These molecules modulate the Calcineurin/NFAT pathway that plays an important role in immune cell activation. Overexpression of NSP1 and infection with live SARS-CoV strongly increased signalling through the Calcineurin/NFAT pathway and enhanced the induction of interleukin 2, compatible with late-stage immunopathogenicity and long-term cytokine dysregulation as observed in severe SARS cases. Conversely, inhibition of cyclophilins by cyclosporine A (CspA blocked the replication of CoVs of all genera, including SARS-CoV, human CoV-229E and -NL-63, feline CoV, as well as avian infectious bronchitis virus. Non-immunosuppressive derivatives of CspA might serve as broad-range CoV inhibitors applicable against emerging CoVs as well as ubiquitous pathogens of humans and livestock.

  3. Enhancement of SAR images using fuzzy shrinkage technique in ...

    Indian Academy of Sciences (India)

    The synthetic aperture radar (SAR) images are mainly affected by speckle noise. Speckle degrades the features in the image and reduces the ability of a human observer to resolve fine detail, hence despeckling is very much required for SAR images. This paper presents speckle noise reduction in SAR images using a ...

  4. Satellite sar detection of hurricane helene (2006)

    DEFF Research Database (Denmark)

    Ju, Lian; Cheng, Yongcun; Xu, Qing

    2013-01-01

    In this paper, the wind structure of hurricane Helene (2006) over the Atlantic Ocean is investigated from a C-band RADARSAT-1 synthetic aperture radar (SAR) image acquired on 20 September 2006. First, the characteristics, e.g., the center, scale and area of the hurricane eye (HE) are determined. ...... observations from the stepped frequency microwave radiometer (SFMR) on NOAA P3 aircraft. All the results show the capability of hurricane monitoring by satellite SAR. Copyright © 2013 by the International Society of Offshore and Polar Engineers (ISOPE)....

  5. The planned Alaska SAR Facility - An overview

    Science.gov (United States)

    Carsey, Frank; Weeks, Wilford

    1987-01-01

    The Alaska SAR Facility (ASF) is described in an overview fashion. The facility consists of three major components, a Receiving Ground System, a SAR Processing System and an Analysis and Archiving System; the ASF Program also has a Science Working Team and the requisite management and operations systems. The ASF is now an approved and fully funded activity; detailed requirements and science background are presented for the facility to be implemented for data from the European ERS-1, the Japanese ERS-1 and Radarsat.

  6. Science data collection with polarimetric SAR

    DEFF Research Database (Denmark)

    Dall, Jørgen; Woelders, Kim; Madsen, Søren Nørvang

    1996-01-01

    Discusses examples on the use of polarimetric SAR in a number of Earth science studies. The studies are presently being conducted by the Danish Center for Remote Sensing. A few studies of the European Space Agency's EMAC programme are also discussed. The Earth science objectives are presented......, and the potential of polarimetric SAR is discussed and illustrated with data collected by the Danish airborne EMISAR system during a number of experiments in 1994 and 1995. The presentation will include samples of data acquired for the different studies...

  7. Estimating IMU heading error from SAR images.

    Energy Technology Data Exchange (ETDEWEB)

    Doerry, Armin Walter

    2009-03-01

    Angular orientation errors of the real antenna for Synthetic Aperture Radar (SAR) will manifest as undesired illumination gradients in SAR images. These gradients can be measured, and the pointing error can be calculated. This can be done for single images, but done more robustly using multi-image methods. Several methods are provided in this report. The pointing error can then be fed back to the navigation Kalman filter to correct for problematic heading (yaw) error drift. This can mitigate the need for uncomfortable and undesired IMU alignment maneuvers such as S-turns.

  8. Geologic mapping in Greenland with polarimetric SAR

    DEFF Research Database (Denmark)

    Dall, Jørgen; Madsen, Søren Nørvang; Brooks, C. K.

    1995-01-01

    mapping is complicated by an extreme topography leading to massive shadowing, foreshortening and layover. An artifact characterised by high cross-polarisation is observed behind many sharp mountain ridges. A multi-reflection hypothesis has been investigated without finding the ultimate proof......The application of synthetic aperture radar (SAR) for geologic mapping in Greenland is investigated by the Danish Center for Remote Sensing (DCRS) in co-operation with the Danish Lithosphere Centre (DLC). In 1994 a pilot project was conducted in East Greenland. The Danish airborne SAR, EMISAR...

  9. SARS knowledge, perceptions, and behaviors: a comparison between Finns and the Dutch during the SARS outbreak in 2003

    NARCIS (Netherlands)

    Vartti, A.M.; Oenema, A.; Schreck, M.; Uutela, A.; Zwart, de O.; Brug, J.; Aro, A.R.

    2009-01-01

    BACKGROUND: The SARS outbreak served to test both local and international outbreak management and risk communication practices. PURPOSE: The study compares SARS knowledge, perceptions, behaviors, and information between Finns and the Dutch during the SARS outbreak in 2003. METHOD: The participants

  10. Estimating the Doppler centroid of SAR data

    DEFF Research Database (Denmark)

    Madsen, Søren Nørvang

    1989-01-01

    After reviewing frequency-domain techniques for estimating the Doppler centroid of synthetic-aperture radar (SAR) data, the author describes a time-domain method and highlights its advantages. In particular, a nonlinear time-domain algorithm called the sign-Doppler estimator (SDE) is shown to hav...

  11. What is Gammarus campylops of Sars, 1894

    NARCIS (Netherlands)

    Stock, J.H.; Kant, P.

    1966-01-01

    A revision of the specimens described by Sars, 1894, as Gammarus campylops Leach, 1814, proved that they did not belong to that species, nor to Gammarus ochlos Reid, 1945 (= G. sarsi Reid, 1943), as Reid believed. Reid’s species, of which also original specimens have been reexamined, is identical

  12. Discovery and SAR of hydantoin TACE inhibitors

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Wensheng; Guo, Zhuyan; Orth, Peter; Madison, Vincent; Chen, Lei; Dai, Chaoyang; Feltz, Robert J.; Girijavallabhan, Vinay M.; Kim, Seong Heon; Kozlowski, Joseph A.; Lavey, Brian J.; Li, Dansu; Lundell, Daniel; Niu, Xiaoda; Piwinski, John J.; Popovici-Muller, Janeta; Rizvi, Razia; Rosner, Kristin E.; Shankar, Bandarpalle B.; Shih, Neng-Yang; Siddiqui, M.A.; Sun, J.; Tong, L.; Umland, S.; Wong, M.K.; Yang, D.Y.; Zhou, G. (Merck)

    2010-09-03

    We disclose inhibitors of TNF-{alpha} converting enzyme (TACE) designed around a hydantoin zinc binding moiety. Crystal structures of inhibitors bound to TACE revealed monodentate coordination of the hydantoin to the zinc. SAR, X-ray, and modeling designs are described. To our knowledge, these are the first reported X-ray structures of TACE with a hydantoin zinc ligand.

  13. Target detection and recognition with polarimetric SAR

    NARCIS (Netherlands)

    Dekker, R.J.; Broek, A.C. van den

    2000-01-01

    Target detection and recognition using polarimetric SAR data has been studied by using PHARUS and RAMSES data collected during the MIMEX campaign. Additionally very high-resolution ISAR data was used. A basic detection and recognition scheme has been developed, which includes polarimetric

  14. SAR Image Despeckling Via Structural Sparse Representation

    Science.gov (United States)

    Lu, Ting; Li, Shutao; Fang, Leyuan; Benediktsson, Jón Atli

    2016-12-01

    A novel synthetic aperture radar (SAR) image despeckling method based on structural sparse representation is introduced. The proposed method utilizes the fact that different regions in SAR images correspond to varying terrain reflectivity. Therefore, SAR images can be split into a heterogeneous class (with a varied terrain reflectivity) and a homogeneous class (with a constant terrain reflectivity). In the proposed method, different sparse representation based despeckling schemes are designed by combining the different region characteristics in SAR images. For heterogeneous regions with rich structure and texture information, structural dictionaries are learned to appropriately represent varied structural characteristics. Specifically, each patch in these regions is sparsely coded with the best fitted structural dictionary, thus good structure preservation can be obtained. For homogenous regions without rich structure and texture information, the highly redundant photometric self-similarity is exploited to suppress speckle noise without introducing artifacts. That is achieved by firstly learning the sub-dictionary, then simultaneously sparsely coding for each group of photometrically similar image patches. Visual and objective experimental results demonstrate the superiority of the proposed method over the-state-of-the-art methods.

  15. CFAR Edge Detector for Polarimetric SAR Images

    DEFF Research Database (Denmark)

    Schou, Jesper; Skriver, Henning; Nielsen, Allan Aasbjerg

    2003-01-01

    Finding the edges between different regions in an image is one of the fundamental steps of image analysis, and several edge detectors suitable for the special statistics of synthetic aperture radar (SAR) intensity images have previously been developed. In this paper, a new edge detector for polar...

  16. The Seamless SAR Archive (SSARA) Project and Other SAR Activities at UNAVCO

    Science.gov (United States)

    Baker, S.; Crosby, C. J.; Meertens, C. M.; Fielding, E. J.; Bryson, G.; Buechler, B.; Nicoll, J.; Baru, C.

    2014-12-01

    The seamless synthetic aperture radar archive (SSARA) implements a seamless distributed access system for SAR data and derived data products (i.e. interferograms). SSARA provides a unified application programming interface (API) for SAR data search and results at the Alaska Satellite Facility and UNAVCO (WInSAR and EarthScope data archives) through the use of simple web services. A federated query service was developed using the unified APIs, providing users a single search interface for both archives. Interest from the international community has prompted an effort to incorporate ESA's Virtual Archive 4 Geohazard Supersites and Natural Laboratories (GSNL) collections and other archives into the federated query service. SSARA also provides Digital Elevation Model access for topographic correction via a simple web service through OpenTopography and tropospheric correction products through JPL's OSCAR service. Additionally, UNAVCO provides data storage capabilities for WInSAR PIs with approved TerraSAR-X and ALOS-2 proposals which allows easier distribution to US collaborators on associated proposals and facilitates data access through the SSARA web services. Further work is underway to incorporate federated data discovery for GSNL across SAR, GPS, and seismic datasets provided by web services from SSARA, GSAC, and COOPEUS.

  17. SAR Raw Data Generation for Complex Airport Scenes

    Directory of Open Access Journals (Sweden)

    Jia Li

    2014-10-01

    Full Text Available The method of generating the SAR raw data of complex airport scenes is studied in this paper. A formulation of the SAR raw signal model of airport scenes is given. Via generating the echoes from the background, aircrafts and buildings, respectively, the SAR raw data of the unified SAR imaging geometry is obtained from their vector additions. The multipath scattering and the shadowing between the background and different ground covers of standing airplanes and buildings are analyzed. Based on the scattering characteristics, coupling scattering models and SAR raw data models of different targets are given, respectively. A procedure is given to generate the SAR raw data of airport scenes. The SAR images from the simulated raw data demonstrate the validity of the proposed method.

  18. New challenges for a SAR toolbox

    International Nuclear Information System (INIS)

    Loreaux, P.; Quin, G.

    2013-01-01

    High resolution multi-frequency synthetic aperture radar (SAR) imagery, available since early 2008, brings all weather capability and day/night operability in support of safeguards verification. Today, a combined approach of high resolution optical and radar imagery in monitoring exercise would enable looking at any area of interest on daily basis. One of the challenges is the co-registration of SAR images acquired with different acquisition mode and also with different optical images. We show in this paper the on-going research work to find a general co-register method and an automatic tool to detect changes. Before having an operational co-register tool, a method to find automatically tie points between SAR images acquired with different acquisition mode and with optical images has to be developed. Concerning an automatic change detection method we can conclude that the study of the Harmonic mean, Geometric mean and Arithmetic mean, enables several applications like change detection for SAR imagery. Thus, we developed the MAGMA (Method for Arithmetic and Geometric Means Analysis) change detection method. As shown in this paper, the MAGMA method improves the Maximum Likelihood techniques like GLRT, using Information-Theory concepts to detect changes between SAR amplitude images. The major improvement consists in a lower false detection rate, especially in low amplitude areas. The second improvement consists in a better location of the changes in clearly delimited areas, which enables precise interpretations. Results presented here reveal the potential of high resolution radar imagery for a baseline description of some sites, change detection based on repeat pass imagery acquisitions and site specific constraints in coherent change detection due to cover conditions. (A.C.)

  19. Broadening of neutralization activity to directly block a dominant antibody-driven SARS-coronavirus evolution pathway.

    Directory of Open Access Journals (Sweden)

    Jianhua Sui

    2008-11-01

    Full Text Available Phylogenetic analyses have provided strong evidence that amino acid changes in spike (S protein of animal and human SARS coronaviruses (SARS-CoVs during and between two zoonotic transfers (2002/03 and 2003/04 are the result of positive selection. While several studies support that some amino acid changes between animal and human viruses are the result of inter-species adaptation, the role of neutralizing antibodies (nAbs in driving SARS-CoV evolution, particularly during intra-species transmission, is unknown. A detailed examination of SARS-CoV infected animal and human convalescent sera could provide evidence of nAb pressure which, if found, may lead to strategies to effectively block virus evolution pathways by broadening the activity of nAbs. Here we show, by focusing on a dominant neutralization epitope, that contemporaneous- and cross-strain nAb responses against SARS-CoV spike protein exist during natural infection. In vitro immune pressure on this epitope using 2002/03 strain-specific nAb 80R recapitulated a dominant escape mutation that was present in all 2003/04 animal and human viruses. Strategies to block this nAb escape/naturally occurring evolution pathway by generating broad nAbs (BnAbs with activity against 80R escape mutants and both 2002/03 and 2003/04 strains were explored. Structure-based amino acid changes in an activation-induced cytidine deaminase (AID "hot spot" in a light chain CDR (complementarity determining region alone, introduced through shuffling of naturally occurring non-immune human VL chain repertoire or by targeted mutagenesis, were successful in generating these BnAbs. These results demonstrate that nAb-mediated immune pressure is likely a driving force for positive selection during intra-species transmission of SARS-CoV. Somatic hypermutation (SHM of a single VL CDR can markedly broaden the activity of a strain-specific nAb. The strategies investigated in this study, in particular the use of structural

  20. DInSAR/PSInSAR Observations of Kirishima, Shinmoe-dake Volcano, Japan

    Science.gov (United States)

    Miyagi, Yousuke; Ozawa, Taku; Kozono, Tomofumi; Shimada, Masanobu

    2013-04-01

    Shinmoe-dake in the Kirishima volcano group is located in southwestern part of Japan. In January 2011, eruptive activities started from the Shinmoe-dake crater and resulted in sub-Plinian and Vulcanian eruptions and a rapid accumulation of lava within the crater. GPS and DInSAR data acquired before and after the eruption revealed pre-eruptive inflation, co-eruptive deflation, and post-eruptive inflation centered on 5km west of the crater. The eruption phase ceased by the beginning of September, and the post-eruptive inflation also ceased by November 2011. After the 2011 eruption, monitoring by TerraSAR-X have continued. Surface change and surface deformation on the lava within the crater were detected by high-resolution amplitude images and DInSAR data. Especially, the surface deformation after September 2011 revealed a continual shortening of satellite-ground distance even after the end of the main activity. This LOS shortening means uplifts of the lava surface. We estimated the volume increase of the lava after November 2011, using DInSAR processing of TerraSAR-X data, and concluded that the volume increase still continued in December 2012. The volume change rate has decreased with a small fluctuation as an overall trend. PSInSAR and long-term DInSAR results helped us to know deformation around the crater. They show LOS elongation including a subsidence in the northeast flank of the crater. It is interpreted that the subsidence is caused by a deflation of shallow deformation source located just beneath the crater.

  1. Ebola Virus and Marburg Virus

    Science.gov (United States)

    Ebola virus and Marburg virus Overview Ebola virus and Marburg virus are related viruses that cause hemorrhagic fevers — illnesses marked by severe bleeding (hemorrhage), organ failure and, in many ...

  2. Identification of synthetic vaccine candidates against SARS CoV infection

    International Nuclear Information System (INIS)

    Lien, Shu-Pei; Shih, Yi-Ping; Chen, Hsin-Wei; Tsai, Jy-Ping; Leng, Chih-Hsiang; Lin, Min-Han; Lin, Li-Hsiu; Liu, Hsin-Yu; Chou, Ai-Hsiang; Chang, Yu-Wen; Chen, Yi-Ming A.; Chong, Pele; Liu, Shih-Jen

    2007-01-01

    Three peptides, D1 (amino acid residues 175-201), D2 (a.a. 434-467), and TM (a.a. 1128-1159), corresponding to the spike protein (S) of severe acute respiratory syndrome corona virus (SARS CoV) were synthesized and their immunological functions were investigated in three different animals models (mice, guinea pigs, and rabbits). The peptides mixture formulated either with Freund's adjuvant or synthetic adjuvant Montanide ISA-51/oligodeoxy nucleotide CpG (ISA/CpG) could elicit antisera in immunized animals which were capable of inhibiting SARS/HIV pseudovirus entry into HepG2 cells. The neutralizing epitopes were identified using peptides to block the neutralizing effect of guinea pig antisera. The major neutralizing epitope was located on the D2 peptide, and the amino acid residue was fine mapped to 434-453. In BALB/c mice T-cell proliferation assay revealed that only D2 peptide contained T-cell epitope, the sequence of which corresponded to amino acid residue 434-448. The ISA/CpG formulation generated anti-D2 IgG titer comparable to those obtained from Freund's adjuvant formulation, but generated fewer antibodies against D1 or TM peptides. The highly immunogenic D2 peptide contains both neutralizing and Th cell epitopes. These results suggest that synthetic peptide D2 would be useful as a component of SARS vaccine candidates

  3. Expression, purification and crystallization of the SARS-CoV macro domain

    Energy Technology Data Exchange (ETDEWEB)

    Malet, Hélène; Dalle, Karen; Brémond, Nicolas; Tocque, Fabienne; Blangy, Stéphanie; Campanacci, Valérie; Coutard, Bruno; Grisel, Sacha; Lichière, Julie; Lantez, Violaine; Cambillau, Christian; Canard, Bruno; Egloff, Marie-Pierre, E-mail: marie-pierre.egloff@afmb.univ-mrs.fr [Centre National de la Recherche Scientifique and Universités d’Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, UMR 6098-Case 932, 163 Avenue de Luminy, 13288 Marseille CEDEX 9 (France)

    2006-04-01

    The SARS-CoV macro domain was expressed, purified and crystallized. Selenomethionine-labelled crystals diffracted to 1.8 Å resolution. Macro domains or X domains are found as modules of multidomain proteins, but can also constitute a protein on their own. Recently, biochemical and structural studies of cellular macro domains have been performed, showing that they are active as ADP-ribose-1′′-phosphatases. Macro domains are also present in a number of positive-stranded RNA viruses, but their precise function in viral replication is still unknown. The major human pathogen severe acute respiratory syndrome coronavirus (SARS-CoV) encodes 16 non-structural proteins (nsps), one of which (nsp3) encompasses a macro domain. The SARS-CoV nsp3 gene region corresponding to amino acids 182–355 has been cloned, expressed in Escherichia coli, purified and crystallized. The crystals belong to space group P2{sub 1}, with unit-cell parameters a = 37.5, b = 55.6, c = 108.9 Å, β = 91.4°, and the asymmetric unit contains either two or three molecules. Both native and selenomethionine-labelled crystals diffract to 1.8 Å.

  4. Spaceborne Polarimetric SAR Interferometry: Performance Analysis and Mission Concepts

    Directory of Open Access Journals (Sweden)

    Shane R. Cloude

    2005-12-01

    Full Text Available We investigate multichannel imaging radar systems employing coherent combinations of polarimetry and interferometry (Pol-InSAR. Such systems are well suited for the extraction of bio- and geophysical parameters by evaluating the combined scattering from surfaces and volumes. This combination leads to several important differences between the design of Pol-InSAR sensors and conventional single polarisation SAR interferometers. We first highlight these differences and then investigate the Pol-InSAR performance of two proposed spaceborne SAR systems (ALOS/PalSAR and TerraSAR-L operating in repeat-pass mode. For this, we introduce the novel concept of a phase tube which enables (1 a quantitative assessment of the Pol-InSAR performance, (2 a comparison between different sensor configurations, and (3 an optimization of the instrument settings for different Pol-InSAR applications. The phase tube may hence serve as an interface between system engineers and application-oriented scientists. The performance analysis reveals major limitations for even moderate levels of temporal decorrelation. Such deteriorations may be avoided in single-pass sensor configurations and we demonstrate the potential benefits from the use of future bi- and multistatic SAR interferometers.

  5. Spaceborne Polarimetric SAR Interferometry: Performance Analysis and Mission Concepts

    Science.gov (United States)

    Krieger, Gerhard; Papathanassiou, Konstantinos Panagiotis; Cloude, Shane R.

    2005-12-01

    We investigate multichannel imaging radar systems employing coherent combinations of polarimetry and interferometry (Pol-InSAR). Such systems are well suited for the extraction of bio- and geophysical parameters by evaluating the combined scattering from surfaces and volumes. This combination leads to several important differences between the design of Pol-InSAR sensors and conventional single polarisation SAR interferometers. We first highlight these differences and then investigate the Pol-InSAR performance of two proposed spaceborne SAR systems (ALOS/PalSAR and TerraSAR-L) operating in repeat-pass mode. For this, we introduce the novel concept of a phase tube which enables (1) a quantitative assessment of the Pol-InSAR performance, (2) a comparison between different sensor configurations, and (3) an optimization of the instrument settings for different Pol-InSAR applications. The phase tube may hence serve as an interface between system engineers and application-oriented scientists. The performance analysis reveals major limitations for even moderate levels of temporal decorrelation. Such deteriorations may be avoided in single-pass sensor configurations and we demonstrate the potential benefits from the use of future bi- and multistatic SAR interferometers.

  6. Federated query services provided by the Seamless SAR Archive project

    Science.gov (United States)

    Baker, S.; Bryson, G.; Buechler, B.; Meertens, C. M.; Crosby, C. J.; Fielding, E. J.; Nicoll, J.; Youn, C.; Baru, C.

    2013-12-01

    The NASA Advancing Collaborative Connections for Earth System Science (ACCESS) seamless synthetic aperture radar (SAR) archive (SSARA) project is a 2-year collaboration between UNAVCO, the Alaska Satellite Facility (ASF), the Jet Propulsion Laboratory (JPL), and OpenTopography at the San Diego Supercomputer Center (SDSC) to design and implement a seamless distributed access system for SAR data and derived data products (i.e. interferograms). A major milestone for the first year of the SSARA project was a unified application programming interface (API) for SAR data search and results at ASF and UNAVCO (WInSAR and EarthScope data archives) through the use of simple web services. A federated query service was developed using the unified APIs, providing users a single search interface for both archives (http://www.unavco.org/ws/brokered/ssara/sar/search). A command line client that utilizes this new service is provided as an open source utility for the community on GitHub (https://github.com/bakerunavco/SSARA). Further API development and enhancements added more InSAR specific keywords and quality control parameters (Doppler centroid, faraday rotation, InSAR stack size, and perpendicular baselines). To facilitate InSAR processing, the federated query service incorporated URLs for DEM (from OpenTopography) and tropospheric corrections (from the JPL OSCAR service) in addition to the URLs for SAR data. This federated query service will provide relevant QC metadata for selecting pairs of SAR data for InSAR processing and all the URLs necessary for interferogram generation. Interest from the international community has prompted an effort to incorporate other SAR data archives (the ESA Virtual Archive 4 and the DLR TerraSAR-X_SSC Geohazard Supersites and Natural Laboratories collections) into the federated query service which provide data for researchers outside the US and North America.

  7. The nucleoprotein of Tomato spotted wilt virus as protein tag for easy purification and enhanced production of recombinant proteins in plants

    NARCIS (Netherlands)

    Lacorte, C.C.; Ribeiro, S.G.; Lohuis, H.; Goldbach, R.W.; Prins, M.W.

    2007-01-01

    Upon infection, Tomato spotted wilt virus (TSWV) forms ribonucleoprotein particles (RNPs) that consist of nucleoprotein (N) and viral RNA. These aggregates result from the homopolymerization of the N protein, and are highly stable in plant cells. These properties feature the N protein as a

  8. Digital demodulator for wide bandwidth SAR

    DEFF Research Database (Denmark)

    Jørgensen, Jørn Hjelm

    2000-01-01

    A novel approach to the design of efficient digital quadrature demodulators for wide bandwidth SAR systems is described. Efficiency is obtained by setting the intermediate frequency to 1/4 the ADC sampling frequency. One channel is made filter-free by synchronizing the local oscillator with the o......A novel approach to the design of efficient digital quadrature demodulators for wide bandwidth SAR systems is described. Efficiency is obtained by setting the intermediate frequency to 1/4 the ADC sampling frequency. One channel is made filter-free by synchronizing the local oscillator...... with the output decimator. The filter required by the other channel is optimized through global search using the system level performance metrics integrated sidelobe level ratio (ISLR) and peak sidelobe level ratio (PSLR)....

  9. Bovine respiratory syncytial virus: first serological evidence in Uruguay.

    Science.gov (United States)

    Costa, M; García, L; Yunus, A S; Rockemann, D D; Samal, S K; Cristina, J

    2000-01-01

    Bovine respiratory syncytial virus (BRSV) is a major cause of respiratory disease in calves resulting in a substantial economic loss for the cattle industry worldwide. In order to determine the presence of BRSV in Uruguay, an immunoenzymatic test was set up, using a recombinant BRSV nucleocapsid (N) protein as the antigen. The N protein was produced in Sf9 insect cells by a recombinant baculovirus expressing the N protein. Serum samples collected from one hundred cattle from four different geographic regions of Uruguay were analyzed. Antibodies against the N protein of BRSV were detected in 95% of the serum samples analyzed. These results show for the first time the presence of BRSV antibodies and suggest a widespread BRSV infection in the cattle population of Uruguay.

  10. SAR Target Recognition via Supervised Discriminative Dictionary Learning and Sparse Representation of the SAR-HOG Feature

    Directory of Open Access Journals (Sweden)

    Shengli Song

    2016-08-01

    Full Text Available Automatic target recognition (ATR in synthetic aperture radar (SAR images plays an important role in both national defense and civil applications. Although many methods have been proposed, SAR ATR is still very challenging due to the complex application environment. Feature extraction and classification are key points in SAR ATR. In this paper, we first design a novel feature, which is a histogram of oriented gradients (HOG-like feature for SAR ATR (called SAR-HOG. Then, we propose a supervised discriminative dictionary learning (SDDL method to learn a discriminative dictionary for SAR ATR and propose a strategy to simplify the optimization problem. Finally, we propose a SAR ATR classifier based on SDDL and sparse representation (called SDDLSR, in which both the reconstruction error and the classification error are considered. Extensive experiments are performed on the MSTAR database under standard operating conditions and extended operating conditions. The experimental results show that SAR-HOG can reliably capture the structures of targets in SAR images, and SDDL can further capture subtle differences among the different classes. By virtue of the SAR-HOG feature and SDDLSR, the proposed method achieves the state-of-the-art performance on MSTAR database. Especially for the extended operating conditions (EOC scenario “Training 17 ∘ —Testing 45 ∘ ”, the proposed method improves remarkably with respect to the previous works.

  11. Multiplier-free filters for wideband SAR

    DEFF Research Database (Denmark)

    Dall, Jørgen; Christensen, Erik Lintz

    2001-01-01

    This paper derives a set of parameters to be optimized when designing filters for digital demodulation and range prefiltering in SAR systems. Aiming at an implementation in field programmable gate arrays (FPGAs), an approach for the design of multiplier-free filters is outlined. Design results ar...... are presented in terms of filter complexity and performance. One filter has been coded in VHDL and preliminary results indicate that the filter can meet a 2 GHz input sample rate....

  12. Human Infection with Avian Influenza A(H7N9) Virus - China

    Science.gov (United States)

    ... response operations Diseases Biorisk reduction Disease outbreak news Human infection with avian influenza A(H7N9) virus – ... Region (SAR) notified WHO of a laboratory-confirmed human infection with avian influenza A(H7N9) virus and ...

  13. Mutation of Asn28 Disrupts the Dimerization and Enzymatic Activity of SARS 3CL

    Energy Technology Data Exchange (ETDEWEB)

    Barrila, J.; Gabelli, S; Bacha, U; Amzel, M; Freire, E

    2010-01-01

    Coronaviruses are responsible for a significant proportion of annual respiratory and enteric infections in humans and other mammals. The most prominent of these viruses is the severe acute respiratory syndrome coronavirus (SARS-CoV) which causes acute respiratory and gastrointestinal infection in humans. The coronavirus main protease, 3CL{sup pro}, is a key target for broad-spectrum antiviral development because of its critical role in viral maturation and high degree of structural conservation among coronaviruses. Dimerization is an indispensable requirement for the function of SARS 3CL{sup pro} and is regulated through mechanisms involving both direct and long-range interactions in the enzyme. While many of the binding interactions at the dimerization interface have been extensively studied, those that are important for long-range control are not well-understood. Characterization of these dimerization mechanisms is important for the structure-based design of new treatments targeting coronavirus-based infections. Here we report that Asn28, a residue 11 {angstrom} from the closest residue in the opposing monomer, is essential for the enzymatic activity and dimerization of SARS 3CLpro. Mutation of this residue to alanine almost completely inactivates the enzyme and results in a 19.2-fold decrease in the dimerization K{sub d}. The crystallographic structure of the N28A mutant determined at 2.35 {angstrom} resolution reveals the critical role of Asn28 in maintaining the structural integrity of the active site and in orienting key residues involved in binding at the dimer interface and substrate catalysis. These findings provide deeper insight into complex mechanisms regulating the activity and dimerization of SARS 3CL{sup pro}.

  14. Feature-Based Nonlocal Polarimetric SAR Filtering

    Directory of Open Access Journals (Sweden)

    Xiaoli Xing

    2017-10-01

    Full Text Available Polarimetric synthetic aperture radar (PolSAR images are inherently contaminated by multiplicative speckle noise, which complicates the image interpretation and image analyses. To reduce the speckle effect, several adaptive speckle filters have been developed based on the weighted average of the similarity measures commonly depending on the model or probability distribution, which are often affected by the distribution parameters and modeling texture components. In this paper, a novel filtering method introduces the coefficient of variance ( CV and Pauli basis (PB to measure the similarity, and the two features are combined with the framework of the nonlocal mean filtering. The CV is used to describe the complexity of various scenes and distinguish the scene heterogeneity; moreover, the Pauli basis is able to express the polarimetric information in PolSAR image processing. This proposed filtering combines the CV and Pauli basis to improve the estimation accuracy of the similarity weights. Then, the similarity of the features is deduced according to the test statistic. Subsequently, the filtering is proceeded by using the nonlocal weighted estimation. The performance of the proposed filter is tested with the simulated images and real PolSAR images, which are acquired by AIRSAR system and ESAR system. The qualitative and quantitative experiments indicate the validity of the proposed method by comparing with the widely-used despeckling methods.

  15. Mutational dynamics of the SARS coronavirus in cell culture and human populations isolated in 2003

    Directory of Open Access Journals (Sweden)

    Ooi Eng

    2004-09-01

    Full Text Available Abstract Background The SARS coronavirus is the etiologic agent for the epidemic of the Severe Acute Respiratory Syndrome. The recent emergence of this new pathogen, the careful tracing of its transmission patterns, and the ability to propagate in culture allows the exploration of the mutational dynamics of the SARS-CoV in human populations. Methods We sequenced complete SARS-CoV genomes taken from primary human tissues (SIN3408, SIN3725V, SIN3765V, cultured isolates (SIN848, SIN846, SIN842, SIN845, SIN847, SIN849, SIN850, SIN852, SIN3408L, and five consecutive Vero cell passages (SIN2774_P1, SIN2774_P2, SIN2774_P3, SIN2774_P4, SIN2774_P5 arising from SIN2774 isolate. These represented individual patient samples, serial in vitro passages in cell culture, and paired human and cell culture isolates. Employing a refined mutation filtering scheme and constant mutation rate model, the mutation rates were estimated and the possible date of emergence was calculated. Phylogenetic analysis was used to uncover molecular relationships between the isolates. Results Close examination of whole genome sequence of 54 SARS-CoV isolates identified before 14th October 2003, including 22 from patients in Singapore, revealed the mutations engendered during human-to-Vero and Vero-to-human transmission as well as in multiple Vero cell passages in order to refine our analysis of human-to-human transmission. Though co-infection by different quasipecies in individual tissue samples is observed, the in vitro mutation rate of the SARS-CoV in Vero cell passage is negligible. The in vivo mutation rate, however, is consistent with estimates of other RNA viruses at approximately 5.7 × 10-6 nucleotide substitutions per site per day (0.17 mutations per genome per day, or two mutations per human passage (adjusted R-square = 0.4014. Using the immediate Hotel M contact isolates as roots, we observed that the SARS epidemic has generated four major genetic groups that are

  16. Experiment of Azimuth-invariant Bistatic UHF UWB SAR

    Science.gov (United States)

    Xie, Hongtu; Shi, Shaoying; Mao, Junfa; Li, Fuhai; An, Daoxiang; Zhou, Zhimin; Wang, Guoqian

    2018-01-01

    Bistatic ultrahigh frequency ultrawideband synthetic aperture radar (UHF UWB SAR) has the well ability of the penetrating the foliage, high-resolution imaging and providing the increased information. In the paper, an imaging experiment of the azimuth-invariant bistatic UHF UWB SAR is described and the result is proposed. In August 2015, an along-track bistatic UHF UWB SAR experiment was conducted in China, and the raw data was collected. In this bistatic SAR system, the transmitter and receiver are both carried by a vehicle and separated by an invariable distance. The aim was to investigate the imaging property of the bistatic UHF UWB SAR system. Bistatic image was obtained using the subaperture spectrum-equilibrium method integrated with the fast factorized back projection algorithm (FFBPA). Experiment results prove the validity of the bistatic UHF UWB SAR experiment.

  17. Polarimetric SAR image classification based on discriminative dictionary learning model

    Science.gov (United States)

    Sang, Cheng Wei; Sun, Hong

    2018-03-01

    Polarimetric SAR (PolSAR) image classification is one of the important applications of PolSAR remote sensing. It is a difficult high-dimension nonlinear mapping problem, the sparse representations based on learning overcomplete dictionary have shown great potential to solve such problem. The overcomplete dictionary plays an important role in PolSAR image classification, however for PolSAR image complex scenes, features shared by different classes will weaken the discrimination of learned dictionary, so as to degrade classification performance. In this paper, we propose a novel overcomplete dictionary learning model to enhance the discrimination of dictionary. The learned overcomplete dictionary by the proposed model is more discriminative and very suitable for PolSAR classification.

  18. Ocean Surface Wind Speed of Hurricane Helene Observed by SAR

    DEFF Research Database (Denmark)

    Xu, Qing; Cheng, Yongcun; Li, Xiaofeng

    2011-01-01

    The hurricanes can be detected by many remote sensors, but synthetic aperture radar (SAR) can yield high-resolution (sub-kilometer) and low-level wind information that cannot be seen below the cloud by other sensors. In this paper, an assessment of SAR capability of monitoring high......-resolution hurricane was conducted. A case study was carried out to retrieve ocean surface wind field from C-band RADARSAT-1 SAR image which captured the structure of hurricane Helene over the Atlantic Ocean on 20 September, 2006. With wind direction from the outputs of U.S. Navy Operational Global Atmospheric...... CIWRAP models have been tested to extract wind speed from SAR data. The SAR retrieved ocean surface winds were compared to the aircraft wind speed observations from stepped frequency microwave radiometer (SFMR). The results show the capability of hurricane wind monitoring by SAR....

  19. SAR Subsets for Selected Field Sites, 2007-2010

    Data.gov (United States)

    National Aeronautics and Space Administration — ABSTRACT: This data set provides Synthetic Aperture Radar (SAR) images for 42 selected sites from various terrestrial ecology and meteorological monitoring networks...

  20. SAR Subsets for Selected Field Sites, 2007-2010

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set provides Synthetic Aperture Radar (SAR) images for 42 selected sites from various terrestrial ecology and meteorological monitoring networks including...

  1. Bistatic SAR: State of the Art and Development Trend

    Directory of Open Access Journals (Sweden)

    Zeng Tao

    2012-12-01

    Full Text Available Bistatic SAR (BiSAR systems have attracted the interests from global researchers and become a hotspot in the international radar community due to the progress of radar technology and rapidly increased applications nowadays. Based on the BiSAR experiments and breakthrough of the key technology, the paper summarized the general progresses of BiSAR systems, especially in European radar community, from different aspects such as system design, processing idea and topology etc. Different bistatic image formation algorithms have been analyzed and reviewed. Finally, the development trend is discussed in the paper.

  2. Evaluation of the Wishart test statistics for polarimetric SAR data

    DEFF Research Database (Denmark)

    Skriver, Henning; Nielsen, Allan Aasbjerg; Conradsen, Knut

    2003-01-01

    A test statistic for equality of two covariance matrices following the complex Wishart distribution has previously been used in new algorithms for change detection, edge detection and segmentation in polarimetric SAR images. Previously, the results for change detection and edge detection have been...... quantitatively evaluated. This paper deals with the evaluation of segmentation. A segmentation performance measure originally developed for single-channel SAR images has been extended to polarimetric SAR images, and used to evaluate segmentation for a merge-using-moment algorithm for polarimetric SAR data....

  3. Cloud storage and computing resources for the UNAVCO SAR Archive

    Science.gov (United States)

    Baker, S.; Crosby, C. J.; Meertens, C. M.

    2016-12-01

    UNAVCO is a non-profit university-governed consortium that operates the National Science Foundation (NSF) Geodesy Advancing Geosciences and EarthScope (GAGE) facility and provides operational support to the Western North America InSAR Consortium (WInSAR). The synthetic aperture radar (SAR) archive at UNAVCO currently provides access to over 70TB of unprocessed data for community geoscience research. Historically, users have downloaded data and performed InSAR processing on local machines. However, given the increasing volumes of SAR data available and the size of an individual scene, this model may be inefficient. As cloud computing has become more mainstream, UNAVCO has begun developing capabilities to provide data and processing resources in the same location. The test environment is using the Texas Advanced Computing Center (TACC), part of the NSF Extreme Science and Engineering Discovery Environment (XSEDE). The entire UNAVCO SAR archive is available at TACC along with virtual machines preconfigured with InSAR processing software. Users will be able to quickly access and process SAR data, providing a scalable computing environment for more efficient and larger scale analyzes by the UNAVCO WInSAR community.

  4. Ezrin interacts with the SARS coronavirus Spike protein and restrains infection at the entry stage.

    Directory of Open Access Journals (Sweden)

    Jean Kaoru Millet

    Full Text Available BACKGROUND: Entry of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV and its envelope fusion with host cell membrane are controlled by a series of complex molecular mechanisms, largely dependent on the viral envelope glycoprotein Spike (S. There are still many unknowns on the implication of cellular factors that regulate the entry process. METHODOLOGY/PRINCIPAL FINDINGS: We performed a yeast two-hybrid screen using as bait the carboxy-terminal endodomain of S, which faces the cytosol during and after opening of the fusion pore at early stages of the virus life cycle. Here we show that the ezrin membrane-actin linker interacts with S endodomain through the F1 lobe of its FERM domain and that both the eight carboxy-terminal amino-acids and a membrane-proximal cysteine cluster of S endodomain are important for this interaction in vitro. Interestingly, we found that ezrin is present at the site of entry of S-pseudotyped lentiviral particles in Vero E6 cells. Targeting ezrin function by small interfering RNA increased S-mediated entry of pseudotyped particles in epithelial cells. Furthermore, deletion of the eight carboxy-terminal amino acids of S enhanced S-pseudotyped particles infection. Expression of the ezrin dominant negative FERM domain enhanced cell susceptibility to infection by SARS-CoV and S-pseudotyped particles and potentiated S-dependent membrane fusion. CONCLUSIONS/SIGNIFICANCE: Ezrin interacts with SARS-CoV S endodomain and limits virus entry and fusion. Our data present a novel mechanism involving a cellular factor in the regulation of S-dependent early events of infection.

  5. Viruses and interactomes in translation.

    Science.gov (United States)

    Meyniel-Schicklin, Laurène; de Chassey, Benoît; André, Patrice; Lotteau, Vincent

    2012-07-01

    A decade of high-throughput screenings for intraviral and virus-host protein-protein interactions led to the accumulation of data and to the development of theories on laws governing interactome organization for many viruses. We present here a computational analysis of intraviral protein networks (EBV, FLUAV, HCV, HSV-1, KSHV, SARS-CoV, VACV, and VZV) and virus-host protein networks (DENV, EBV, FLUAV, HCV, and VACV) from up-to-date interaction data, using various mathematical approaches. If intraviral networks seem to behave similarly, they are clearly different from the human interactome. Viral proteins target highly central human proteins, which are precisely the Achilles' heel of the human interactome. The intrinsic structural disorder is a distinctive feature of viral hubs in virus-host interactomes. Overlaps between virus-host data sets identify a core of human proteins involved in the cellular response to viral infection and in the viral capacity to hijack the cell machinery for viral replication. Host proteins that are strongly targeted by a virus seem to be particularly attractive for other viruses. Such protein-protein interaction networks and their analysis represent a powerful resource from a therapeutic perspective.

  6. Hydrodynamics of the groundwater-fed Sian Ka'an Wetlands, Mexico, From InSAR and SAR Data

    DEFF Research Database (Denmark)

    Gondwe, Bibi Ruth Neuman; Hong, S.; Wdowinski, S.

    2008-01-01

    of no hurricanes, maximum extent of flooding occurs in November-December, 1-2 months after the end of the rainy season (2640 to 2980 km2). The smallest degree of flooding occurs in May (1350 km2) at the end of the dry season. This information along with relative water level change maps may be used for improved...... to understand, quantify and predict the wetland dynamics. Remotely sensed Interferometric Synthetic Aperture Radar (InSAR) and Synthetic Aperture Radar (SAR) data offer new opportunities to get hydrodynamic information, which is useful for wetland management. InSAR data produces temporal phase......-changes of the backscattered radar signal, which can be related to the water level changes in vegetated wetlands. SAR data reveals information of surface properties such as the degree of flooding through the amplitude of the backscattered signal. We used RADARSAT-1 InSAR and SAR data to form 36 interferograms and 13 flooding...

  7. Analysis of summer subsidence in Barrow, Alaska, using InSAR and hyperspectral remote sensing

    OpenAIRE

    Mahmud Haghshenas Haghighi; M. Motagh; B. Heim; S. Chabrillat; D. Streletskiy; G. Grosse; T. Sachs; Katrin Kohnert

    2016-01-01

    In this study, gradual elevation change due to summer thawing of active layer in tundra permafrost landscape of Barrow, Alaska is investigated using SAR interferometry (InSAR) technique. We used a variety of SAR sensors including TerraSAR-X, ALOS, and Sentinel-1 images to assess elevation changes in summer season. Preliminary result, obtained by TerraSAR-X InSAR analysis, clearly delineates subsidence during the summer by identifying thousands of coherent pixels on ...

  8. SarA is a repressor of hla (alpha-hemolysin) transcription in Staphylococcus aureus: its apparent role as an activator of hla in the prototype strain NCTC 8325 depends on reduced expression of sarS.

    Science.gov (United States)

    Oscarsson, Jan; Kanth, Anna; Tegmark-Wisell, Karin; Arvidson, Staffan

    2006-12-01

    In most Staphylococcus aureus strains, inactivation of sarA increases hla transcription, indicating that sarA is a repressor. However, in S. aureus NCTC 8325 and its derivatives, used for most studies of hla regulation, inactivation of sarA resulted in decreased hla transcription. The disparate phenotype of strain NCTC 8325 seems to be associated with its rsbU mutation, which leads to sigma(B) deficiency. This has now been verified by the demonstration that sarA repressed hla transcription in an rsbU+ derivative of strain 8325-4 (SH1000). That sarA could act as a repressor of hla in an 8325-4 background was confirmed by the observation that inactivation of sarA in an agr sarS rot triple mutant dramatically increased hla transcription to wild-type levels. However, the apparent role of sarA as an activator of hla in 8325-4 was not a result of the rsbU mutation alone, as inactivation of sarA in another rsbU mutant, strain V8, led to increased hla transcription. Northern blot analysis revealed much higher levels of sarS mRNA in strain V8 than in 8325-4, which was likely due to the mutation in the sarS activator, tcaR, in 8325-4, which was not found in strain V8. On the other hand, the relative increase in sarS transcription upon the inactivation of sarA was 15-fold higher in 8325-4 than in strain V8. Because of this, inactivation of sarA in 8325-4 means a net increase in repressor activity, whereas in strain V8, inactivation of sarA means a net decrease in repressor activity and, therefore, enhanced hla transcription.

  9. Vaccinia virus Vaccinia complement control protein: Multi-functional ...

    Indian Academy of Sciences (India)

    Unknown

    Mysteries of the smallpox vaccine. 141. Viral mimicry. Viral mimicry of the complement system. 249. Viral molecules. Vaccinia complement control protein: Multi-functional pro- tein and a potential wonder drug. 265. Viral pneumonia. Severe acute respiratory syndrome (SARS): an old virus jumping into a new host or a new ...

  10. Satellite on-board real-time SAR processor prototype

    Science.gov (United States)

    Bergeron, Alain; Doucet, Michel; Harnisch, Bernd; Suess, Martin; Marchese, Linda; Bourqui, Pascal; Desnoyers, Nicholas; Legros, Mathieu; Guillot, Ludovic; Mercier, Luc; Châteauneuf, François

    2017-11-01

    A Compact Real-Time Optronic SAR Processor has been successfully developed and tested up to a Technology Readiness Level of 4 (TRL4), the breadboard validation in a laboratory environment. SAR, or Synthetic Aperture Radar, is an active system allowing day and night imaging independent of the cloud coverage of the planet. The SAR raw data is a set of complex data for range and azimuth, which cannot be compressed. Specifically, for planetary missions and unmanned aerial vehicle (UAV) systems with limited communication data rates this is a clear disadvantage. SAR images are typically processed electronically applying dedicated Fourier transformations. This, however, can also be performed optically in real-time. Originally the first SAR images were optically processed. The optical Fourier processor architecture provides inherent parallel computing capabilities allowing real-time SAR data processing and thus the ability for compression and strongly reduced communication bandwidth requirements for the satellite. SAR signal return data are in general complex data. Both amplitude and phase must be combined optically in the SAR processor for each range and azimuth pixel. Amplitude and phase are generated by dedicated spatial light modulators and superimposed by an optical relay set-up. The spatial light modulators display the full complex raw data information over a two-dimensional format, one for the azimuth and one for the range. Since the entire signal history is displayed at once, the processor operates in parallel yielding real-time performances, i.e. without resulting bottleneck. Processing of both azimuth and range information is performed in a single pass. This paper focuses on the onboard capabilities of the compact optical SAR processor prototype that allows in-orbit processing of SAR images. Examples of processed ENVISAT ASAR images are presented. Various SAR processor parameters such as processing capabilities, image quality (point target analysis), weight and

  11. Permanent scatterer InSAR processing: Forsmark

    International Nuclear Information System (INIS)

    Dehls, John F.

    2006-04-01

    It has been speculated that slow, aseismic movement may be occurring along some of the fracture zones crosscutting the Forsmark area. The purpose of this study is to determine if it is possible to measure such movement using dInSAR. Differential SAR Interferometry (DInSAR) is a technique that compares the phases of multiple radar images of an area to measure surface change. The method has the potential to detect millimetric surface deformation along the sensor - target line-of-sight. Differences in phase between two images are easily viewed by combining, or interfering, the two phase-images. In the resulting image, the waves will either reinforce or cancel one another, depending upon the relative phases. The resulting image is called an interferogram and contains concentric bands of colour, or fringes, that are related to topography and/or surface deformation. New algorithms use many images acquired over a long time period to determine the movement history of individual objects, referred to as permanent scatterers. In the current project, standard PSInSAR processing was performed on 40 ERS-1 and ERS-2 scenes. The total area processed is approximately 1,500 km 2 . Slightly less than 20,000 permanent scatterers were identified.The highest densities were obtained along the coast and on the islands, where natural outcrops are more abundant. Two main classes of objects act as permanent scatterers in this area. The first are natural reflectors, such as rocks. The second are man-made reflectors, such as parts of buildings. Numerous local movements were found in the study area, relating to building subsidence, or compaction of anthropogenic fill. The dataset was divided into three groups for analysis, based upon the location of regional lineaments provided by SKB. Both statistical and geostatistical techniques were used. The median velocity of the three blocks did not differ by more than 0.2 mm/yr. This is not considered significant, given the possible magnitude of errors

  12. The GF-3 SAR Data Processor.

    Science.gov (United States)

    Han, Bing; Ding, Chibiao; Zhong, Lihua; Liu, Jiayin; Qiu, Xiaolan; Hu, Yuxin; Lei, Bin

    2018-03-10

    The Gaofen-3 (GF-3) data processor was developed as a workstation-based GF-3 synthetic aperture radar (SAR) data processing system. The processor consists of two vital subsystems of the GF-3 ground segment, which are referred to as data ingesting subsystem (DIS) and product generation subsystem (PGS). The primary purpose of DIS is to record and catalogue GF-3 raw data with a transferring format, and PGS is to produce slant range or geocoded imagery from the signal data. This paper presents a brief introduction of the GF-3 data processor, including descriptions of the system architecture, the processing algorithms and its output format.

  13. Two dimensional estimates from ocean SAR images

    Directory of Open Access Journals (Sweden)

    J. M. Le Caillec

    1996-01-01

    Full Text Available Synthetic Aperture Radar (SAR images of the ocean yield a lot of information on the sea-state surface providing that the mapping process between the surface and the image is clearly defined. However it is well known that SAR images exhibit non-gaussian statistics and that the motion of the scatterers on the surface, while the image is being formed, may yield to nonlinearities. The detection and quantification of these nonlinearities are made possible by using Higher Order Spectra (HOS methods and more specifically, bispectrum estimation. The development of the latter method allowed us to find phase relations between different parts of the image and to recognise their level of coupling, i.e. if and how waves of different wavelengths interacted nonlinearly. This information is quite important as the usual models assume strong nonlinearities when the waves are propagating in the azimuthal direction (i.e. along the satellite track and almost no nonlinearities when propagating in the range direction. In this paper, the mapping of the ocean surface to the SAR image is reinterpreted and a specific model (i.e. a Second Order Volterra Model is introduced. The nonlinearities are thus explained as either produced by a nonlinear system or due to waves propagating into selected directions (azimuth or range and interacting during image formation. It is shown that quadratic nonlinearities occur for waves propagating near the range direction while for those travelling in the azimuthal direction the nonlinearities, when present, are mostly due to wave interactions but are almost completely removed by the filtering effect coming from the surface motion itself (azimuth cut-off. An inherent quadratic interaction filtering (azimuth high pass filter is also present. But some other effects, apparently nonlinear, are not detected with the methods described here, meaning that either the usual relation developed for the Ocean-to-SAR transform is somewhat incomplete

  14. Permanent scatterer InSAR processing: Forsmark

    Energy Technology Data Exchange (ETDEWEB)

    Dehls, John F. [Geological Survey of Norway, Trondheim (Norway)

    2006-04-15

    It has been speculated that slow, aseismic movement may be occurring along some of the fracture zones crosscutting the Forsmark area. The purpose of this study is to determine if it is possible to measure such movement using dInSAR. Differential SAR Interferometry (DInSAR) is a technique that compares the phases of multiple radar images of an area to measure surface change. The method has the potential to detect millimetric surface deformation along the sensor - target line-of-sight. Differences in phase between two images are easily viewed by combining, or interfering, the two phase-images. In the resulting image, the waves will either reinforce or cancel one another, depending upon the relative phases. The resulting image is called an interferogram and contains concentric bands of colour, or fringes, that are related to topography and/or surface deformation. New algorithms use many images acquired over a long time period to determine the movement history of individual objects, referred to as permanent scatterers. In the current project, standard PSInSAR processing was performed on 40 ERS-1 and ERS-2 scenes. The total area processed is approximately 1,500 km{sup 2}. Slightly less than 20,000 permanent scatterers were identified.The highest densities were obtained along the coast and on the islands, where natural outcrops are more abundant. Two main classes of objects act as permanent scatterers in this area. The first are natural reflectors, such as rocks. The second are man-made reflectors, such as parts of buildings. Numerous local movements were found in the study area, relating to building subsidence, or compaction of anthropogenic fill. The dataset was divided into three groups for analysis, based upon the location of regional lineaments provided by SKB. Both statistical and geostatistical techniques were used. The median velocity of the three blocks did not differ by more than 0.2 mm/yr. This is not considered significant, given the possible magnitude of

  15. Cloaked similarity between HIV-1 and SARS-CoV suggests an anti-SARS strategy

    Directory of Open Access Journals (Sweden)

    Kliger Yossef

    2003-09-01

    Full Text Available Abstract Background Severe acute respiratory syndrome (SARS is a febrile respiratory illness. The disease has been etiologically linked to a novel coronavirus that has been named the SARS-associated coronavirus (SARS-CoV, whose genome was recently sequenced. Since it is a member of the Coronaviridae, its spike protein (S2 is believed to play a central role in viral entry by facilitating fusion between the viral and host cell membranes. The protein responsible for viral-induced membrane fusion of HIV-1 (gp41 differs in length, and has no sequence homology with S2. Results Sequence analysis reveals that the two viral proteins share the sequence motifs that construct their active conformation. These include (1 an N-terminal leucine/isoleucine zipper-like sequence, and (2 a C-terminal heptad repeat located upstream of (3 an aromatic residue-rich region juxtaposed to the (4 transmembrane segment. Conclusions This study points to a similar mode of action for the two viral proteins, suggesting that anti-viral strategy that targets the viral-induced membrane fusion step can be adopted from HIV-1 to SARS-CoV. Recently the FDA approved Enfuvirtide, a synthetic peptide corresponding to the C-terminal heptad repeat of HIV-1 gp41, as an anti-AIDS agent. Enfuvirtide and C34, another anti HIV-1 peptide, exert their inhibitory activity by binding to a leucine/isoleucine zipper-like sequence in gp41, thus inhibiting a conformational change of gp41 required for its activation. We suggest that peptides corresponding to the C-terminal heptad repeat of the S2 protein may serve as inhibitors for SARS-CoV entry.

  16. Investigation of Polarimetric SAR Data Acquired at Multiple Incidence Angles

    DEFF Research Database (Denmark)

    Svendsen, Morten Thougaard; Skriver, Henning; Thomsen, A.

    1998-01-01

    The dependence of different polarimetric parameters on the incidence angles in the range of 30° to 60° is investigated for a number of different crops using airborne SAR data. The purpose of the investigation is to determine the effect of the variation of incidence angle within a SAR image when...

  17. The Recent Severe Acute Respiratory Syndrome (SARS) Epidemic ...

    African Journals Online (AJOL)

    Severe Acute Respiratory syndrome (SARS) took the world by storm in the later part of February 2003.It is a syndrome characterized by fever, cough, sore throat , shortness of breath and malaise which may deteriorate very rapidly to respiratory failure and death. The symptoms of SARS are quite similar to those of common ...

  18. Genome organization of the SARS-CoV

    DEFF Research Database (Denmark)

    Xu, Jing; Hu, Jianfei; Wang, Jing

    2003-01-01

    Annotation of the genome sequence of the SARS-CoV (severe acute respiratory syndrome-associated coronavirus) is indispensable to understand its evolution and pathogenesis. We have performed a full annotation of the SARS-CoV genome sequences by using annotation programs publicly available or devel...

  19. An Adaptive Ship Detection Scheme for Spaceborne SAR Imagery

    Directory of Open Access Journals (Sweden)

    Xiangguang Leng

    2016-08-01

    Full Text Available With the rapid development of spaceborne synthetic aperture radar (SAR and the increasing need of ship detection, research on adaptive ship detection in spaceborne SAR imagery is of great importance. Focusing on practical problems of ship detection, this paper presents a highly adaptive ship detection scheme for spaceborne SAR imagery. It is able to process a wide range of sensors, imaging modes and resolutions. Two main stages are identified in this paper, namely: ship candidate detection and ship discrimination. Firstly, this paper proposes an adaptive land masking method using ship size and pixel size. Secondly, taking into account the imaging mode, incidence angle, and polarization channel of SAR imagery, it implements adaptive ship candidate detection in spaceborne SAR imagery by applying different strategies to different resolution SAR images. Finally, aiming at different types of typical false alarms, this paper proposes a comprehensive ship discrimination method in spaceborne SAR imagery based on confidence level and complexity analysis. Experimental results based on RADARSAT-1, RADARSAT-2, TerraSAR-X, RS-1, and RS-3 images demonstrate that the adaptive scheme proposed in this paper is able to detect ship targets in a fast, efficient and robust way.

  20. Calibration of SAR probes in waveguide at 900 MHz

    International Nuclear Information System (INIS)

    Jokela, K.; Puranen, L.; Hyysalo, P.

    1998-01-01

    The radiation safety tests for hand-held mobile phones require precise calibration of the small electric field probes used for the measurement of SAR in phantoms simulating the human body. In this study a calibration based on a rectangular waveguide was developed for SAR calibrations at 900 MHz

  1. Demonstrator for Automatic Target Classification in SAR Imagery

    NARCIS (Netherlands)

    Wit, J.J.M. de; Broek, A.C. van den; Dekker, R.J.

    2006-01-01

    Due to the increasing use of unmanned aerial vehicles (UAV) for reconnaissance, surveillance, and target acquisition applications, the interest in synthetic aperture radar (SAR) systems is growing. In order to facilitate the processing of the enormous amount of SAR data on the ground, automatic

  2. Project PHARUS: Towards a polarimetric C-band airborne SAR

    NARCIS (Netherlands)

    Hoogeboom, P.; Koomen, P.J.; Otten, M.P.G.; Pouwels, H.; Snoeij, P.

    1989-01-01

    A few years ago three institutes in the Netherlands developed a plan to design and build a polarimetric C-band aircraft SAR system of a novel design, called PHARUS (PHased Array Universal SAR), meant as a replacement for our current digital SLAR system. These institutes are the Physics and

  3. The Danish polarimetric SAR for remote sensing applications

    DEFF Research Database (Denmark)

    Christensen, Erik Lintz; Madsen, Søren Nørvang; Dall, Jørgen

    1994-01-01

    Presents the Danish polarimetric SAR system, EMISAR, and the approach taken in the system design to achieve a reliable high performance system. The design and implementation of the antenna system as well as the analog and digital hardware are discussed. The SAR utilises a dual polarised microstri...

  4. Reliability of SAR ADCs and associated embedded instrument detection

    NARCIS (Netherlands)

    Wan, J.; Kerkhoff, Hans G.

    2015-01-01

    Successive-approximation-register (SAR) analog-to-digital converters (ADCs) represent the majority of the ADC market from medium to high resolution ADCs. Due to its low power, high-performance and small area in Mega-Hz range, SAR ADCs are increasingly attractive for todays safe-critical applications

  5. Assessing ScanSAR Interferometry for Deformation Studies

    Science.gov (United States)

    Buckley, S. M.; Gudipati, K.

    2007-12-01

    There is a trend in civil satellite SAR mission design to implement an imaging strategy that incorporates both stripmap mode and ScanSAR imaging. This represents a compromise between high resolution data collection and a desire for greater spatial coverage and more frequent revisit times. However, mixed mode imaging can greatly reduce the number of stripmap images available for measuring subtle ground deformation. Although ScanSAR-ScanSAR and ScanSAR-stripmap repeat-pass interferometry have been demonstrated, these approaches are infrequently used for single interferogram formation and nonexistent for InSAR time series analysis. For future mission design, e.g., a dedicated US InSAR mission, the effect of various ScanSAR system parameter choices on InSAR time series analysis also remains unexplored. Our objective is to determine the utility of ScanSAR differential interferometry. We will demonstrate the use of ScanSAR interferograms for several previous deformation studies: localized and broad-scale urban land subsidence, tunneling, volcanic surface movements and several examples associated with the seismic cycle. We also investigate the effect of various ScanSAR burst synchronization levels on our ability to detect and make quality measurements of deformation. To avoid the issues associated with Envisat ScanSAR burst alignment and to exploit a decade of InSAR measurements, we simulate ScanSAR data by bursting (throwing away range lines of) ERS-1/2 data. All the burst mode datasets are processed using a Modified SPECAN algorithm. To investigate the effects of burst misalignment, a number of cases with varying degrees of burst overlap are considered. In particular, we look at phase decorrelation as a function of percentage of burst overlap. Coherence clearly reduces as the percentage of overlap decreases and we find a useful threshold of 40-70% burst overlap depending on the study site. In order to get a more generalized understanding for different surface conditions

  6. INVENTORY OF IRRIGATED RICE ECOSYSTEM USING POLARIMETRIC SAR DATA

    Directory of Open Access Journals (Sweden)

    P. Srikanth

    2012-08-01

    Full Text Available An attempt has been made in the current study to assess the potential of polarimetric SAR data for inventory of kharif rice and the major competing crop like cotton. In the process, physical process of the scattering mechanisms occurring in rice and cotton crops at different phonological stages was studied through the use of temporal Radarsat 2 Fine quadpol SAR data. The temporal dynamics of the volume, double and odd bounce, entropy, anisotropy, alpha parameters and polarimertic signatures, classification through isodata clustering and Wishart techniques were assessed. The Wishart (H-a classification showed higher overall as well as rice and cotton crop accuracies compared to the isodata clustering from Freeman 3-component decomposition. The classification of temporal SAR data sets independently showed that the rice crop forecasting can be advanced with the use of appropriate single date polarimetric SAR data rather than using temporal SAR amplitude data sets with the single polarization in irrigated rice ecosystems

  7. MULTI-TEMPORAL SAR CHANGE DETECTION AND MONITORING

    Directory of Open Access Journals (Sweden)

    S. Hachicha

    2012-08-01

    Full Text Available Multitemporal SAR images are a very useful source of information for a large amount of applications, especially for change detection and monitoring. In this paper, a new SAR change detection and monitoring approach is proposed through the analysis of a time series of SAR images covering the same region. The first step of the method is the SAR filtering preprocessing step using an extension of the spatial NL-means filter to the temporal domain. Then, the Rayleigh Kullback Leibler and the Rayleigh Distribution Ratio measures are combined to detect the changes between a reference image and each SAR image of the time series at both local and global scale. These measures are combined using the Dezert-Smarandache theory which takes into account conflicts between sources and thus enhances the dual change detection results. Finally, a pixel based temporal classification is applied starting from the obtained change maps in order to describe the temporal behaviour of the covered regions.

  8. A new detection method of oil rigs in SAR imagery

    Science.gov (United States)

    Chen, Peng; Yang, Jingsong; Ren, Lin

    2013-10-01

    It's difficult for simple space-borne SAR to identify oil rigs effectively in single pass SAR image. One method of oil rig detection is using multi-temporal SAR images. Some papers had do some research on it. In this paper, we use interferometry SAR image to detect the oil rigs. We get the correlation coefficient image from the In-SAR data, and using the histogram of correlation coefficient image, A Constant False Alarm Rate (CFAR) algorithm is imported to detect the oil rigs. The Probabilistic Neural Network (PNN) is used to get the threshold of detection. The test result shows that sea coherent target detection in the coherent coefficient image is efficacious.

  9. Ship surveillance with Radarsat-2 ScanSAR

    Science.gov (United States)

    Wang, Ziwei; Zhang, Hong; Wang, Chao; Wu, Fan

    2014-10-01

    Ship detection is a significant application of maritime monitoring and security. To fully explore the potential of wide coverage of synthetic aperture radar (SAR) image, the ScanSAR Wide image for ship detection is investigated in this paper. The Radarsat-2 ScanSAR Wide mode image is used as the image source due to its huge coverage and constant false alarm rate (CFAR) with Gamma distribution is selected as the core detector. Two problems of ScanSAR ship detection, the unbalanced phenomenon and false alarms of islands, are investigated and solved by a compensation step and Hessian matrix respectively. For more aspects, the detector also concerns the polarization channel selection and distribution fitting. Finally, a whole flow chart of ScanSAR ship detection is presented. As test cases, the experimental image is used to show the efficiency of our method.

  10. Guided SAR image despeckling with probabilistic non local weights

    Science.gov (United States)

    Gokul, Jithin; Nair, Madhu S.; Rajan, Jeny

    2017-12-01

    SAR images are generally corrupted by granular disturbances called speckle, which makes visual analysis and detail extraction a difficult task. Non Local despeckling techniques with probabilistic similarity has been a recent trend in SAR despeckling. To achieve effective speckle suppression without compromising detail preservation, we propose an improvement for the existing Generalized Guided Filter with Bayesian Non-Local Means (GGF-BNLM) method. The proposed method (Guided SAR Image Despeckling with Probabilistic Non Local Weights) replaces parametric constants based on heuristics in GGF-BNLM method with dynamically derived values based on the image statistics for weight computation. Proposed changes make GGF-BNLM method adaptive and as a result, significant improvement is achieved in terms of performance. Experimental analysis on SAR images shows excellent speckle reduction without compromising feature preservation when compared to GGF-BNLM method. Results are also compared with other state-of-the-art and classic SAR depseckling techniques to demonstrate the effectiveness of the proposed method.

  11. Advanced Antenna Design for NASA's EcoSAR Instrument

    Science.gov (United States)

    Du Toit, Cornelis F.; Deshpande, Manohar; Rincon, Rafael F.

    2016-01-01

    Advanced antenna arrays were designed for NASA's EcoSAR airborne radar instrument. EcoSAR is a beamforming synthetic aperture radar instrument designed to make polarimetric and "single pass" interferometric measurements of Earth surface parameters. EcoSAR's operational requirements of a 435MHz center frequency with up to 200MHz bandwidth, dual polarization, high cross-polarization isolation (> 30 dB), +/- 45deg beam scan range and antenna form-factor constraints imposed stringent requirements on the antenna design. The EcoSAR project successfully developed, characterized, and tested two array antennas in an anechoic chamber. EcoSAR's first airborne campaign conducted in the spring of 2014 generated rich data sets of scientific and engineering value, demonstrating the successful operation of the antennas.

  12. Ice flow mapping with P-band SAR

    DEFF Research Database (Denmark)

    Dall, Jørgen; Nielsen, Ulrik; Kusk, Anders

    2013-01-01

    -band SAR data have been acquired in Greenland, and both offset tracking and DInSAR have been applied to the full resolution data as well as to data degraded to the resolution of Biomass. Generally, ice velocity maps are successfully generated, but in the ablation zone, DInSAR fails in the melt season......Glacier and ice sheet dynamics are currently mapped with X-, C-, and L-band SAR. With the prospect of a P-band SAR, Biomass, to be launched within the next decade it is interesting to look into the potential of P-band for ice velocity mapping. In this paper first results are presented. Airborne P...

  13. SARS-Coronavirus ancestor's foot-prints in South-East Asian bat colonies and the refuge theory.

    Science.gov (United States)

    Gouilh, Meriadeg Ar; Puechmaille, Sébastien J; Gonzalez, Jean-Paul; Teeling, Emma; Kittayapong, Pattamaporn; Manuguerra, Jean-Claude

    2011-10-01

    One of the great challenges in the ecology of infectious diseases is to understand what drives the emergence of new pathogens including the relationship between viruses and their hosts. In the case of the emergence of SevereAcute Respiratory Syndrome Coronavirus (SARS-CoV), several studies have shown coronavirus diversity in bats as well as the existence of SARS-CoV infection in apparently healthy bats, suggesting that bats may be a crucial host in the genesis of this disease. To elucidate the biogeographic origin of SARS-CoV and investigate the role that bats played in its emergence, we amplified coronavirus sequences from bat species captured throughout Thailand and assessed the phylogenetic relationships to each other and to other published coronavirus sequences. To this end, RdRp sequence of Coronavirinae was targeted by RT-PCR in non-invasive samples from bats collected in Thailand. Two new coronaviruses were detected in two bat species: one Betacoronavirus in Hipposideros larvatus and one Alphacoronavirus in Hipposiderosarmiger. Interestingly, these viruses from South-East Asia are related to those previously detected in Africa (Betacoronavirus-b) or in Europe (Alphacoronavirus & Betacoronavirus-b). These findings illuminate the origin and the evolutionary history of the SARS-CoV group found in bats by pushing forward the hypothesis of a Betacoronavirus spill-over from Hipposideridae to Rhinolophidae and then from Rhinolophidae to civets and Human. All reported Betacoronaviruses-b (SARS-CoV group) of Hipposideridae and Rhinolophidae respectively cluster in two groups despite their broad geographic distribution and the sympatry of their hosts, which is in favor of an ancient and genetically independent evolution of Betacoronavirus-b clusters in these families. Moreover, despite its probable pathogenicity, we found that a Betacoronavirus-b can persistently infect a medium-sized hipposiderid bat colony. These findings illustrate the importance of the host

  14. SarT, a Repressor of α-Hemolysin in Staphylococcus aureus

    Science.gov (United States)

    Schmidt, Katherine A.; Manna, Adhar C.; Gill, Steven; Cheung, Ambrose L.

    2001-01-01

    In searching the Staphylococcus aureus genome, we found several homologs to SarA. One of these genes, sarT, codes for a basic protein with 118 residues and a predicted molecular size of 16,096 Da. Northern blot analysis revealed that the expression of sarT was repressed by sarA and agr. An insertion sarT mutant generated in S. aureus RN6390 and 8325-4 backgrounds revealed minimal effect on the expression of sarR and sarA. The RNAIII level was notably increased in the sarT mutant, particularly in postexponential-phase cells, while the augmentative effect on RNAII was less. SarT repressed the expression of α-hemolysin, as determined by Northern blotting, Western blotting, and a rabbit erythrocyte hemolytic assay. This repression was relieved upon complementation. Similar to agr and sarA mutants, which predictably displayed a reduction in hla expression, the agr sarT mutant exhibited a lower level of hla transcription than the sarT mutant. In contrast, hla transcription was enhanced in the sarA sarT mutant compared with the single sarA mutant. Collectively, these results indicated that the sarA locus, contrary to the regulatory action of agr, induced α-hemolysin production by repressing sarT, a repressor of hla transcription. PMID:11447147

  15. SAR Image despeckling via sparse representation

    Science.gov (United States)

    Wang, Zhongmei; Yang, Xiaomei; Zheng, Liang

    2014-11-01

    SAR image despeckling is an active research area in image processing due to its importance in improving the quality of image for object detection and classification.In this paper, a new approach is proposed for multiplicative noise in SAR image removal based on nonlocal sparse representation by dictionary learning and collaborative filtering. First, a image is divided into many patches, and then a cluster is formed by clustering log-similar image patches using Fuzzy C-means (FCM). For each cluster, an over-complete dictionary is computed using the K-SVD method that iteratively updates the dictionary and the sparse coefficients. The patches belonging to the same cluster are then reconstructed by a sparse combination of the corresponding dictionary atoms. The reconstructed patches are finally collaboratively aggregated to build the denoised image. The experimental results show that the proposed method achieves much better results than many state-of-the-art algorithms in terms of both objective evaluation index (PSNR and ENL) and subjective visual perception.

  16. 3D Monitoring of Buildings Using TerraSAR-X InSAR, DInSAR and PolSAR Capacities

    Directory of Open Access Journals (Sweden)

    Flora Weissgerber

    2017-09-01

    Full Text Available The rapid expansion of cities increases the need of urban remote sensing for a large scale monitoring. This paper provides greater understanding of how TerraSAR-X (TSX high-resolution abilities enable to reach the spatial precision required to monitor individual buildings, through the use of a 4 year temporal stack of 100 images over Paris (France. Three different SAR modes are investigated for this purpose. First a method involving a whole time-series is proposed to measure realistic heights of buildings. Then, we show that the small wavelength of TSX makes the interferometric products very sensitive to the ordinary building-deformation, and that daily deformation can be measured over the entire building with a centimetric accuracy, and without any a priori on the deformation evolution, even when neglecting the impact of the atmosphere. Deformations up to 4 cm were estimated for the Eiffel Tower and up to 1 cm for other lower buildings. These deformations were analyzed and validated with weather and in situ local data. Finally, four TSX polarimetric images were used to investigate geometric and dielectric properties of buildings under the deterministic framework. Despite of the resolution loss of this mode, the possibility to estimate the structural elements of a building orientations and their relative complexity in the spatial organization are demonstrated.

  17. Modelling of potentially promising SARS protease inhibitors

    Energy Technology Data Exchange (ETDEWEB)

    Plewczynski, Dariusz [Interdisciplinary Centre for Mathematical and Computational Modelling, ICM, Warsaw University, Pawinskiego 5a Street, 02-106 Warsaw (Poland); Hoffmann, Marcin [BioInfoBank Institute, Limanowskiego 24A/16, 60-744 Poznan (Poland); Grotthuss, Marcin von [BioInfoBank Institute, Limanowskiego 24A/16, 60-744 Poznan (Poland); Knizewski, Lukasz [Interdisciplinary Centre for Mathematical and Computational Modelling, ICM, Warsaw University, Pawinskiego 5a Street, 02-106 Warsaw (Poland); Rychewski, Leszek [BioInfoBank Institute, Limanowskiego 24A/16, 60-744 Poznan (Poland); Eitner, Krystian [BioInfoBank Institute, Limanowskiego 24A/16, 60-744 Poznan (Poland); Ginalski, Krzysztof [Interdisciplinary Centre for Mathematical and Computational Modelling, ICM, Warsaw University, Pawinskiego 5a Street, 02-106 Warsaw (Poland)

    2007-07-18

    In many cases, at the beginning of a high throughput screening experiment some information about active molecules is already available. Active compounds (such as substrate analogues, natural products and inhibitors of related proteins) are often identified in low throughput validation studies on a biochemical target. Sometimes the additional structural information is also available from crystallographic studies on protein and ligand complexes. In addition, the structural or sequence similarity of various protein targets yields a novel possibility for drug discovery. Co-crystallized compounds from homologous proteins can be used to design leads for a new target without co-crystallized ligands. In this paper we evaluate how far such an approach can be used in a real drug campaign, with severe acute respiratory syndrome (SARS) coronavirus providing an example. Our method is able to construct small molecules as plausible inhibitors solely on the basis of the set of ligands from crystallized complexes of a protein target, and other proteins from its structurally homologous family. The accuracy and sensitivity of the method are estimated here by the subsequent use of an electronic high throughput screening flexible docking algorithm. The best performing ligands are then used for a very restrictive similarity search for potential inhibitors of the SARS protease within the million compounds from the Ligand.Info small molecule meta-database. The selected molecules can be passed on for further experimental validation.

  18. The Ecosystems SAR (EcoSAR) an Airborne P-band Polarimetric InSAR for the Measurement of Vegetation Structure, Biomass and Permafrost

    Science.gov (United States)

    Rincon, Rafael F.; Fatoyinbo, Temilola; Ranson, K. Jon; Osmanoglu, Batuhan; Sun, Guoqing; Deshpande, Manohar D.; Perrine, Martin L.; Du Toit, Cornelis F.; Bonds, Quenton; Beck, Jaclyn; hide

    2014-01-01

    EcoSAR is a new synthetic aperture radar (SAR) instrument being developed at the NASA/ Goddard Space Flight Center (GSFC) for the polarimetric and interferometric measurements of ecosystem structure and biomass. The instrument uses a phased-array beamforming architecture and supports full polarimetric measurements and single pass interferometry. This Instrument development is part of NASA's Earth Science Technology Office Instrument Incubator Program (ESTO IIP).

  19. Elucidating the Interacting Domains of Chandipura Virus Nucleocapsid Protein

    Directory of Open Access Journals (Sweden)

    Kapila Kumar

    2013-01-01

    Full Text Available The nucleocapsid (N protein of Chandipura virus (CHPV plays a crucial role in viral life cycle, besides being an important structural component of the virion through proper organization of its interactions with other viral proteins. In a recent study, the authors had mapped the associations among CHPV proteins and shown that N protein interacts with four of the viral proteins: N, phosphoprotein (P, matrix protein (M, and glycoprotein (G. The present study aimed to distinguish the regions of CHPV N protein responsible for its interactions with other viral proteins. In this direction, we have generated the structure of CHPV N protein by homology modeling using SWISS-MODEL workspace and Accelrys Discovery Studio client 2.55 and mapped the domains of N protein using PiSQRD. The interactions of N protein fragments with other proteins were determined by ZDOCK rigid-body docking method and validated by yeast two-hybrid and ELISA. The study revealed a unique binding site, comprising of amino acids 1–30 at the N terminus of the nucleocapsid protein (N1 that is instrumental in its interactions with N, P, M, and G proteins. It was also observed that N2 associates with N and G proteins while N3 interacts with N, P, and M proteins.

  20. 76 FR 35949 - Agency Information Collection Activity (Servicer's Staff Appraisal Reviewer (SAR) Application...

    Science.gov (United States)

    2011-06-20

    ... Collection Activity (Servicer's Staff Appraisal Reviewer (SAR) Application) Under OMB Review AGENCY: Veterans...: Servicer's Staff Appraisal Reviewer (SAR) Application, VA Form 26-0829. OMB Control Number: 2900-0715. Type... servicers to nominate employees for approval as Staff Appraisal Reviewer (SAR). Servicers SAR's will have...

  1. Spacial Variation in SAR Images of Different Resolution for Agricultural Fields

    DEFF Research Database (Denmark)

    Sandholt, Inge; Skriver, Henning

    1999-01-01

    The spatial variation in two types of Synthetic Aperture Radar (SAR) images covering agricultural fields is analysed. C-band polarimetric SAR data from the Danish airborne SAR, EMISAR, have been compared to space based ERS-1 C-band SAR with respect to scale and effect of polarization. The general...

  2. Pains and Gains from China’s Experiences with Emerging Epidemics: From SARS to H7N9

    Directory of Open Access Journals (Sweden)

    Pengfei Wei

    2016-01-01

    Full Text Available Over the recent decades, China experienced several emerging virus outbreaks including those caused by the severe acute respiratory syndrome- (SARS- coronavirus (Cov, H5N1 virus, and H7N9 virus. The SARS tragedy revealed faults in China’s infectious disease prevention system, propelling the Chinese government to enact reforms that enabled better combating of the subsequent H1N1 and H7N9 avian flu epidemics. The system is buttressed by three fundamental, mutually reinforcing components: (1 enduring government administration reforms, including legislation establishing a unified public health emergency management system; (2 prioritized funding for biotechnology and biomedicine industrialization, especially in the areas of pathogen identification, drug production, and the development of vaccines and diagnostics; and (3 increasing investment for public health and establishment of a rapid-response infectious diseases prevention and control system. China is now using its hard-gained experience to support the fight against Ebola in Africa and the Middle East Respiratory Syndrome in its own country.

  3. Research on Airborne SAR Imaging Based on Esc Algorithm

    Science.gov (United States)

    Dong, X. T.; Yue, X. J.; Zhao, Y. H.; Han, C. M.

    2017-09-01

    Due to the ability of flexible, accurate, and fast obtaining abundant information, airborne SAR is significant in the field of Earth Observation and many other applications. Optimally the flight paths are straight lines, but in reality it is not the case since some portion of deviation from the ideal path is impossible to avoid. A small disturbance from the ideal line will have a major effect on the signal phase, dramatically deteriorating the quality of SAR images and data. Therefore, to get accurate echo information and radar images, it is essential to measure and compensate for nonlinear motion of antenna trajectories. By means of compensating each flying trajectory to its reference track, MOCO method corrects linear phase error and quadratic phase error caused by nonlinear antenna trajectories. Position and Orientation System (POS) data is applied to acquiring accuracy motion attitudes and spatial positions of antenna phase centre (APC). In this paper, extend chirp scaling algorithm (ECS) is used to deal with echo data of airborne SAR. An experiment is done using VV-Polarization raw data of C-band airborne SAR. The quality evaluations of compensated SAR images and uncompensated SAR images are done in the experiment. The former always performs better than the latter. After MOCO processing, azimuth ambiguity is declined, peak side lobe ratio (PSLR) effectively improves and the resolution of images is improved obviously. The result shows the validity and operability of the imaging process for airborne SAR.

  4. RESEARCH ON AIRBORNE SAR IMAGING BASED ON ESC ALGORITHM

    Directory of Open Access Journals (Sweden)

    X. T. Dong

    2017-09-01

    Full Text Available Due to the ability of flexible, accurate, and fast obtaining abundant information, airborne SAR is significant in the field of Earth Observation and many other applications. Optimally the flight paths are straight lines, but in reality it is not the case since some portion of deviation from the ideal path is impossible to avoid. A small disturbance from the ideal line will have a major effect on the signal phase, dramatically deteriorating the quality of SAR images and data. Therefore, to get accurate echo information and radar images, it is essential to measure and compensate for nonlinear motion of antenna trajectories. By means of compensating each flying trajectory to its reference track, MOCO method corrects linear phase error and quadratic phase error caused by nonlinear antenna trajectories. Position and Orientation System (POS data is applied to acquiring accuracy motion attitudes and spatial positions of antenna phase centre (APC. In this paper, extend chirp scaling algorithm (ECS is used to deal with echo data of airborne SAR. An experiment is done using VV-Polarization raw data of C-band airborne SAR. The quality evaluations of compensated SAR images and uncompensated SAR images are done in the experiment. The former always performs better than the latter. After MOCO processing, azimuth ambiguity is declined, peak side lobe ratio (PSLR effectively improves and the resolution of images is improved obviously. The result shows the validity and operability of the imaging process for airborne SAR.

  5. Emerging Viruses in the Felidae: Shifting Paradigms

    Directory of Open Access Journals (Sweden)

    Meredith A. Brown

    2012-02-01

    Full Text Available The domestic cat is afflicted with multiple viruses that serve as powerful models for human disease including cancers, SARS and HIV/AIDS. Cat viruses that cause these diseases have been studied for decades revealing detailed insight concerning transmission, virulence, origins and pathogenesis. Here we review recent genetic advances that have questioned traditional wisdom regarding the origins of virulent Feline infectious peritonitis (FIP diseases, the pathogenic potential of Feline Immunodeficiency Virus (FIV in wild non-domestic Felidae species, and the restriction of Feline Leukemia Virus (FeLV mediated immune impairment to domestic cats rather than other Felidae species. The most recent interpretations indicate important new evolutionary conclusions implicating these deadly infectious agents in domestic and non-domestic felids.

  6. Emerging Viruses in the Felidae: Shifting Paradigms

    Science.gov (United States)

    O’Brien, Stephen J.; Troyer, Jennifer L.; Brown, Meredith A.; Johnson, Warren E.; Antunes, Agostinho; Roelke, Melody E.; Pecon-Slattery, Jill

    2012-01-01

    The domestic cat is afflicted with multiple viruses that serve as powerful models for human disease including cancers, SARS and HIV/AIDS. Cat viruses that cause these diseases have been studied for decades revealing detailed insight concerning transmission, virulence, origins and pathogenesis. Here we review recent genetic advances that have questioned traditional wisdom regarding the origins of virulent Feline infectious peritonitis (FIP) diseases, the pathogenic potential of Feline Immunodeficiency Virus (FIV) in wild non-domestic Felidae species, and the restriction of Feline Leukemia Virus (FeLV) mediated immune impairment to domestic cats rather than other Felidae species. The most recent interpretations indicate important new evolutionary conclusions implicating these deadly infectious agents in domestic and non-domestic felids. PMID:22470834

  7. Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?

    Science.gov (United States)

    Chan, Jasper F W; Li, Kenneth S M; To, Kelvin K W; Cheng, Vincent C C; Chen, Honglin; Yuen, Kwok-Yung

    2012-12-01

    Fouchier et al. reported the isolation and genome sequencing of a novel coronavirus tentatively named "human betacoronavirus 2c EMC/2012 (HCoV-EMC)" from a Saudi patient presenting with pneumonia and renal failure in June 2012. Genome sequencing showed that this virus belongs to the group C species of the genus betacoronavirus and phylogenetically related to the bat coronaviruses HKU4 and HKU5 previously found in lesser bamboo bat and Japanese Pipistrelle bat of Hong Kong respectively. Another patient from Qatar with similar clinical presentation and positive RT-PCR test was reported in September 2012. We compare and contrast the clinical presentation, laboratory diagnosis and management of infection due to this novel coronavirus and that of SARS coronavirus despite the paucity of published information on the former. Since 70% of all emerging infectious pathogens came from animals, the emergence of this novel virus may represent another instance of interspecies jumping of betacoronavirus from animals to human similar to the group A coronavirus OC43 possibly from a bovine source in the 1890s and the group B SARS coronavirus in 2003 from bat to civet and human. Despite the apparently low transmissibility of the virus at this stage, research preparedness against another SARS-like pandemic is an important precautionary strategy. Copyright © 2012 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

  8. Genetic variation of the human α-2-Heremans-Schmid glycoprotein (AHSG gene associated with the risk of SARS-CoV infection.

    Directory of Open Access Journals (Sweden)

    Xiaohui Zhu

    Full Text Available Genetic background may play an important role in the process of SARS-CoV infection and SARS development. We found several proteins that could interact with the nucleocapsid protein of the SARS coronavirus (SARS-CoV. α-2-Heremans-Schmid Glycoprotein (AHSG, which is required for macrophage deactivation by endogenous cations, is associated with inflammatory regulation. Cytochrome P450 Family 3A (CYP4F3A is an ω-oxidase that inactivates Leukotriene B4 (LTB4 in human neutrophils and the liver. We investigated the association between the polymorphisms of these two inflammation-associated genes and SARS development. The linkage disequilibrium (LD maps of these two genes were built with Haploview using data on CHB+JPT (version 2 from the HapMap. A total of ten tag SNPs were selected and genotyped. In the Guangzhou cohort study, after adjusting for age and sex, two AHSG SNPs and one CYP4F3 SNP were found to be associated with SARS susceptibility: rs2248690 (adjusted odds ratio [AOR] 2.42; 95% confidence interval [CI] 1.30-4.51; rs4917 (AOR 1.84; 95% CI 1.02-3.34; and rs3794987 (AOR 2.01; 95% CI 1.10-3.68. To further validate the association, the ten tag SNPs were genotyped in the Beijing cohort. After adjusting for age and sex, only rs2248690 (AOR, 1.63; 95% CI, 1.30-2.04 was found to be associated with SARS susceptibility. The combined analysis of the two studies confirmed tag SNP rs2248690 in AHSG as a susceptibility variant (AOR 1.70; 95% CI 1.37-2.09. The statistical analysis of the rs2248690 genotype data among the patients and healthy controls in the HCW cohort, who were all similarly exposed to the SARS virus, also supported the findings. Further, the SNP rs2248690 affected the transcriptional activity of the AHSG promoter and thus regulated the AHSG serum level. Therefore, our study has demonstrated that the AA genotype of rs2268690, which leads to a higher AHSG serum concentration, was significantly associated with protection against SARS

  9. FlexSAR, a high quality, flexible, cost effective, prototype SAR system

    Science.gov (United States)

    Jensen, Mark; Knight, Chad; Haslem, Brent

    2016-05-01

    The FlexSAR radar system was designed to be a high quality, low-cost, flexible research prototype instrument. Radar researchers and practitioners often desire the ability to prototype new or advanced configurations, yet the ability to enhance or upgrade existing radar systems can be cost prohibitive. FlexSAR answers the need for a flexible radar system that can be extended easily, with minimal cost and time expenditures. The design approach focuses on reducing the resources required for developing and validating new advanced radar modalities. Such an approach fosters innovation and provides risk reduction since actual radar data can be collected in the appropriate mode, processed, and analyzed early in the development process. This allows for an accurate, detailed understanding of the corresponding trade space. This paper is a follow-on to last years paper and discusses the advancements that have been made to the FlexSAR system. The overall system architecture is discussed and presented along with several examples illustrating the system utility.

  10. Wind mapping offshore in coastal Mediterranean area using SAR images

    DEFF Research Database (Denmark)

    Calaudi, Rosamaria; Arena, Felice; Badger, Merete

    Satellite observations of the ocean surface from Synthetic Aperture Radars (SAR) provide information about the spatial wind variability over large areas. This is of special interest in the Mediterranean, where spatial wind information is only provided by sparse buoys, often with long periods...... of missing data. Here, we focus on evaluating the use of SAR for offshore wind mapping. Preliminary results from the analysis of SAR-based ocean winds in Mediterranean areas show interesting large scale wind flow features consistent with results from previous studies using numerical models and space borne...

  11. Pre-Processes for Urban Areas Detection in SAR Images

    Science.gov (United States)

    Altay Açar, S.; Bayır, Ş.

    2017-11-01

    In this study, pre-processes for urban areas detection in synthetic aperture radar (SAR) images are examined. These pre-processes are image smoothing, thresholding and white coloured regions determination. Image smoothing is carried out to remove noises then thresholding is applied to obtain binary image. Finally, candidate urban areas are detected by using white coloured regions determination. All pre-processes are applied by utilizing the developed software. Two different SAR images which are acquired by TerraSAR-X are used in experimental study. Obtained results are shown visually.

  12. SAR image effects on coherence and coherence estimation.

    Energy Technology Data Exchange (ETDEWEB)

    Bickel, Douglas Lloyd

    2014-01-01

    Radar coherence is an important concept for imaging radar systems such as synthetic aperture radar (SAR). This document quantifies some of the effects in SAR which modify the coherence. Although these effects can disrupt the coherence within a single SAR image, this report will focus on the coherence between separate images, such as for coherent change detection (CCD) processing. There have been other presentations on aspects of this material in the past. The intent of this report is to bring various issues that affect the coherence together in a single report to support radar engineers in making decisions about these matters.

  13. Mapping and monitoring renewable resources with space SAR

    Science.gov (United States)

    Ulaby, F. T.; Brisco, B.; Dobson, M. C.; Moezzi, S.

    1983-01-01

    The SEASAT-A SAR and SIR-A imagery was examined to evaluate the quality and type of information that can be extracted and used to monitor renewable resources on Earth. Two tasks were carried out: (1) a land cover classification study which utilized two sets of imagery acquired by the SEASAT-A SAR, one set by SIR-A, and one LANDSAT set (4 bands); and (2) a change detection to examine differences between pairs of SEASAT-A SAR images and relates them to hydrologic and/or agronomic variations in the scene.

  14. InSAR processing for the recognition of landslides

    Directory of Open Access Journals (Sweden)

    B. Riedel

    2008-01-01

    Full Text Available Synthetic Aperture Radar Interferometry (InSAR is an established method for the detection and monitoring of earth surface processes. This approach has been most successful where the observed area fulfills specific requirements, such as sufficient backscattering, flat slope gradients or very slow changes of vegetation. We investigated the capability of two different InSAR techniques and achieved good results for the recognition of landslides in China and Greece that compared well with geodetic derived movement rates. This demonstrates the strong potential of SAR Interferometry for the detection of landslides and earth surface movements.

  15. Compact polarimetric SAR product and calibration considerations for target analysis

    Science.gov (United States)

    Sabry, Ramin

    2016-10-01

    Compact polarimetric (CP) data exploitation is currently of growing interest considering the new generation of such Synthetic Aperture Radar (SAR) systems. These systems offer target detection and classification capabilities comparable to those of polarimetric SARs (PolSAR) with less stringent requirements. A good example is the RADARSAT Constellation Mission (RCM). In this paper, some characteristic CP products are described and effects of CP mode deviation from ideal circular polarization transmit on classifications are modeled. The latter is important for operation of typical CP modes (e.g., RCM). The developed model can be used to estimate the ellipticity variation from CP measured data, and hence, calibrate the classification products.

  16. SAR antenna design for ambiguity and multipath suppression

    DEFF Research Database (Denmark)

    Christensen, Erik Lintz; Dich, Mikael

    1993-01-01

    A high resolution airborne synthetic aperture radar (SAR) has been developed at the Electromagnetics Institute (EMI) for remote sensing applications. The paper considers the radiation of antennas for a SAR system from a systems perspective. The basic specifications of an idealised antenna...... are obtained from the required swath and the azimuth footprint needed for the SAR processing. The radiation from a real antenna causes unwanted signal returns that lead to intensity variations (multipath) and ghost echoes (ambiguity). Additional specifications are deduced by considering these signals...

  17. A RAIL CENTRAL DISPLACEMENT METHOD ABOUT GB-SAR

    OpenAIRE

    J. Peng; J. Cai; H. Yang

    2016-01-01

    This paper presents a new method to correct rail errors of Ground Based Synthetic Aperture Radar (GB-SAR) in the discontinue mode. Generally, “light positioning” is performed to mark the GB-SAR position in the dis-continuous observation mode. Usually we assume there is no difference between the marked position and the real installation position. But in fact, it is hard to keep the GB-SAR positions of two campaigns the same, so repositioning errors can’t be neglected. In order to solve this pr...

  18. Program Merges SAR Data on Terrain and Vegetation Heights

    Science.gov (United States)

    Siqueira, Paul; Hensley, Scott; Rodriguez, Ernesto; Simard, Marc

    2007-01-01

    X/P Merge is a computer program that estimates ground-surface elevations and vegetation heights from multiple sets of data acquired by the GeoSAR instrument [a terrain-mapping synthetic-aperture radar (SAR) system that operates in the X and bands]. X/P Merge software combines data from X- and P-band digital elevation models, SAR backscatter magnitudes, and interferometric correlation magnitudes into a simplified set of output topographical maps of ground-surface elevation and tree height.

  19. Characterization of uncultivable bat influenza virus using a replicative synthetic virus.

    Directory of Open Access Journals (Sweden)

    Bin Zhou

    2014-10-01

    Full Text Available Bats harbor many viruses, which are periodically transmitted to humans resulting in outbreaks of disease (e.g., Ebola, SARS-CoV. Recently, influenza virus-like sequences were identified in bats; however, the viruses could not be cultured. This discovery aroused great interest in understanding the evolutionary history and pandemic potential of bat-influenza. Using synthetic genomics, we were unable to rescue the wild type bat virus, but could rescue a modified bat-influenza virus that had the HA and NA coding regions replaced with those of A/PR/8/1934 (H1N1. This modified bat-influenza virus replicated efficiently in vitro and in mice, resulting in severe disease. Additional studies using a bat-influenza virus that had the HA and NA of A/swine/Texas/4199-2/1998 (H3N2 showed that the PR8 HA and NA contributed to the pathogenicity in mice. Unlike other influenza viruses, engineering truncations hypothesized to reduce interferon antagonism into the NS1 protein didn't attenuate bat-influenza. In contrast, substitution of a putative virulence mutation from the bat-influenza PB2 significantly attenuated the virus in mice and introduction of a putative virulence mutation increased its pathogenicity. Mini-genome replication studies and virus reassortment experiments demonstrated that bat-influenza has very limited genetic and protein compatibility with Type A or Type B influenza viruses, yet it readily reassorts with another divergent bat-influenza virus, suggesting that the bat-influenza lineage may represent a new Genus/Species within the Orthomyxoviridae family. Collectively, our data indicate that the bat-influenza viruses recently identified are authentic viruses that pose little, if any, pandemic threat to humans; however, they provide new insights into the evolution and basic biology of influenza viruses.

  20. Characterization of uncultivable bat influenza virus using a replicative synthetic virus.

    Science.gov (United States)

    Zhou, Bin; Ma, Jingjiao; Liu, Qinfang; Bawa, Bhupinder; Wang, Wei; Shabman, Reed S; Duff, Michael; Lee, Jinhwa; Lang, Yuekun; Cao, Nan; Nagy, Abdou; Lin, Xudong; Stockwell, Timothy B; Richt, Juergen A; Wentworth, David E; Ma, Wenjun

    2014-10-01

    Bats harbor many viruses, which are periodically transmitted to humans resulting in outbreaks of disease (e.g., Ebola, SARS-CoV). Recently, influenza virus-like sequences were identified in bats; however, the viruses could not be cultured. This discovery aroused great interest in understanding the evolutionary history and pandemic potential of bat-influenza. Using synthetic genomics, we were unable to rescue the wild type bat virus, but could rescue a modified bat-influenza virus that had the HA and NA coding regions replaced with those of A/PR/8/1934 (H1N1). This modified bat-influenza virus replicated efficiently in vitro and in mice, resulting in severe disease. Additional studies using a bat-influenza virus that had the HA and NA of A/swine/Texas/4199-2/1998 (H3N2) showed that the PR8 HA and NA contributed to the pathogenicity in mice. Unlike other influenza viruses, engineering truncations hypothesized to reduce interferon antagonism into the NS1 protein didn't attenuate bat-influenza. In contrast, substitution of a putative virulence mutation from the bat-influenza PB2 significantly attenuated the virus in mice and introduction of a putative virulence mutation increased its pathogenicity. Mini-genome replication studies and virus reassortment experiments demonstrated that bat-influenza has very limited genetic and protein compatibility with Type A or Type B influenza viruses, yet it readily reassorts with another divergent bat-influenza virus, suggesting that the bat-influenza lineage may represent a new Genus/Species within the Orthomyxoviridae family. Collectively, our data indicate that the bat-influenza viruses recently identified are authentic viruses that pose little, if any, pandemic threat to humans; however, they provide new insights into the evolution and basic biology of influenza viruses.

  1. SAR polar format implementation with MATLAB.

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Grant D.; Doerry, Armin Walter

    2005-11-01

    Traditional polar format image formation for Synthetic Aperture Radar (SAR) requires a large amount of processing power and memory in order to accomplish in real-time. These requirements can thus eliminate the possible usage of interpreted language environments such as MATLAB. However, with trapezoidal aperture phase history collection and changes to the traditional polar format algorithm, certain optimizations make MATLAB a possible tool for image formation. Thus, this document's purpose is two-fold. The first outlines a change to the existing Polar Format MATLAB implementation utilizing the Chirp Z-Transform that improves performance and memory usage achieving near realtime results for smaller apertures. The second is the addition of two new possible image formation options that perform a more traditional interpolation style image formation. These options allow the continued exploration of possible interpolation methods for image formation and some preliminary results comparing image quality are given.

  2. Cross-calibration of interferometric SAR data

    DEFF Research Database (Denmark)

    Dall, Jørgen

    2003-01-01

    Generation of digital elevation models from interferometric synthetic aperture radar (SAR) data is a well established technique. Achieving a high geometric fidelity calls for a calibration accounting for inaccurate navigation data and system parameters as well as system imperfections. Fully......, but not necessarily from map to map. It is based on natural distributed targets for which no a priori knowledge is needed. In particular, no DEM is required as in calibration techniques based on dedicated calibration scenes. To achieve absolute calibration, i.e. elimination of a constant elevation offset, a single...... ground control point is often needed. The paper presents the principles and mathematics of the cross-calibration technique and illustrates its successful application to EMISAR data....

  3. ECHO virus

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/001340.htm ECHO virus To use the sharing features on this page, please enable JavaScript. Enteric cytopathic human orphan (ECHO) viruses are a group of viruses that can lead ...

  4. A NEW SAR CLASSIFICATION SCHEME FOR SEDIMENTS ON INTERTIDAL FLATS BASED ON MULTI-FREQUENCY POLARIMETRIC SAR IMAGERY

    Directory of Open Access Journals (Sweden)

    W. Wang

    2017-11-01

    Full Text Available We present a new classification scheme for muddy and sandy sediments on exposed intertidal flats, which is based on synthetic aperture radar (SAR data, and use ALOS-2 (L-band, Radarsat-2 (C-band and TerraSAR-X (X-band fully polarimetric SAR imagery to demonstrate its effectiveness. Four test sites on the German North Sea coast were chosen, which represent typical surface compositions of different sediments, vegetation, and habitats, and of which a large amount of SAR is used for our analyses. Both Freeman-Durden and Cloude-Pottier polarimetric decomposition are utilized, and an additional descriptor called Double-Bounce Eigenvalue Relative Difference (DERD is introduced into the feature sets instead of the original polarimetric intensity channels. The classification is conducted following Random Forest theory, and the results are verified using ground truth data from field campaigns and an existing classification based on optical imagery. In addition, the use of Kennaugh elements for classification purposes is demonstrated using both fully and dual-polarization multi-frequency and multi-temporal SAR data. Our results show that the proposed classification scheme can be applied for the discrimination of muddy and sandy sediments using L-, C-, and X-band SAR images, while SAR imagery acquired at short wavelengths (C- and X-band can also be used to detect more detailed features such as bivalve beds on intertidal flats.

  5. Decreasing range resolution of a SAR image to permit correction of motion measurement errors beyond the SAR range resolution

    Science.gov (United States)

    Doerry, Armin W.; Heard, Freddie E.; Cordaro, J. Thomas

    2010-07-20

    Motion measurement errors that extend beyond the range resolution of a synthetic aperture radar (SAR) can be corrected by effectively decreasing the range resolution of the SAR in order to permit measurement of the error. Range profiles can be compared across the slow-time dimension of the input data in order to estimate the error. Once the error has been determined, appropriate frequency and phase correction can be applied to the uncompressed input data, after which range and azimuth compression can be performed to produce a desired SAR image.

  6. Genome-wide analysis of protein-protein interactions and involvement of viral proteins in SARS-CoV replication.

    Directory of Open Access Journals (Sweden)

    Ji'an Pan

    Full Text Available Analyses of viral protein-protein interactions are an important step to understand viral protein functions and their underlying molecular mechanisms. In this study, we adopted a mammalian two-hybrid system to screen the genome-wide intraviral protein-protein interactions of SARS coronavirus (SARS-CoV and therefrom revealed a number of novel interactions which could be partly confirmed by in vitro biochemical assays. Three pairs of the interactions identified were detected in both directions: non-structural protein (nsp 10 and nsp14, nsp10 and nsp16, and nsp7 and nsp8. The interactions between the multifunctional nsp10 and nsp14 or nsp16, which are the unique proteins found in the members of Nidovirales with large RNA genomes including coronaviruses and toroviruses, may have important implication for the mechanisms of replication/transcription complex assembly and functions of these viruses. Using a SARS-CoV replicon expressing a luciferase reporter under the control of a transcription regulating sequence, it has been shown that several viral proteins (N, X and SUD domains of nsp3, and nsp12 provided in trans stimulated the replicon reporter activity, indicating that these proteins may regulate coronavirus replication and transcription. Collectively, our findings provide a basis and platform for further characterization of the functions and mechanisms of coronavirus proteins.

  7. A RAIL CENTRAL DISPLACEMENT METHOD ABOUT GB-SAR

    Directory of Open Access Journals (Sweden)

    J. Peng

    2016-06-01

    Full Text Available This paper presents a new method to correct rail errors of Ground Based Synthetic Aperture Radar (GB-SAR in the discontinue mode. Generally, “light positioning” is performed to mark the GB-SAR position in the dis-continuous observation mode. Usually we assume there is no difference between the marked position and the real installation position. But in fact, it is hard to keep the GB-SAR positions of two campaigns the same, so repositioning errors can’t be neglected. In order to solve this problem, we propose an algorithm to correct the rail error after analyzing the GB-SAR rail error geometry. Results of the simulation experiment and the real experiment of a landslide in Lvliang, Shanxi, China, show the proposed method achieves an mm-level precision, enabling the D-GBSAR mode to be used in engineering projects.

  8. The economic impact of SARS in Beijing, China.

    Science.gov (United States)

    Beutels, Philippe; Jia, Na; Zhou, Qing-Yi; Smith, Richard; Cao, Wu-Chun; de Vlas, Sake J

    2009-11-01

    To document the impact of the severe acute respiratory syndrome (SARS) outbreak in Beijing on indicators of social and economic activity. Associations between time series of daily and monthly SARS cases and deaths and volume of public train, airplane and cargo transport, tourism, household consumption patterns and gross domestic product growth in Beijing were investigated using the cross-correlation function. Significant correlation coefficients were found for all indicators except wholesale accounts and expenditures on necessities, with the most significant correlations occurring with a delay of 1 day to 1 month. Especially leisure activities, local and international transport and tourism were affected by SARS particularly in May 2003. Much of this consumption was merely postponed; but irrecoverable losses to the tourist sector alone were estimated at about US$ 1.4 bn, or 300 times the cost of treatment for SARS cases in Beijing.

  9. New military uses for synthetic aperture radar (SAR)

    Science.gov (United States)

    Reamer, Richard E.; Stockton, Wayne; Stromfors, Richard D.

    1993-02-01

    Loral Defense Systems-Arizona, holder of the original patent for the invention of Synthetic Aperture Radar (SAR), developed SAR to meet the military's need for an all-weather, day/night sensor that could produce high quality reconnaissance imagery in adverse weather and restricted visibility conditions. These features, and the ability to image large areas with fine resolution in a relatively short period of time make this sensor useful for many military applications. To date, however, SARs for military use have been hampered by the fact that they've been large, complex, and expensive. Additionally, they have been mounted on special purpose, single mission aircraft which are costly to operate. That situation has changed. A small, modular SAR, called Miniature Synthetic Aperture Radar (MSAR) developed by Loral can be mounted with relative ease on Unmanned Aerial Vehicles (UAV) or on multi-mission aircraft such as the F-16, F/A-18, or on the F-14.

  10. Modeling amplitude SAR image with the Cauchy-Rayleigh mixture

    Science.gov (United States)

    Peng, Qiangqiang; Du, Qingyu; Yao, Yinwei; Huang, Huang

    2017-10-01

    In this paper, we introduce a novel mixture model of the SAR amplitude image, which is proposed as an approximation to the heavy-tailed Rayleigh model. The limitation of the heavy-tailed Rayleigh model in SAR image application is discussed. We also present an expectation-maximization (EM) algorithm based parameter estimation method for the Cauchy-Rayleigh mixture. We test the new model on some simulated data in order to confirm that is appropriate to the heavy-tailed Rayleigh model. The performance is evaluated by some statistic values (cumulative square errors (CSE) 0.99 and Kolmogorov-Smirnov distance (K-S) the performance of the proposed mixture model is tested on some real SAR images and compared with other models, including the heavy-tailed Rayleigh and Nakagami mixture models. The result indicates that the proposed model can be an optional statistical model for amplitude SAR images.

  11. Stellwagen Bank National Marine Sanctuary - Synthetic Aperture Radar (SAR) Imagery

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This geodatabase contains Synthetic Aperture Radar images (SAR), which consist of a fine resolution (12.5-50m), two-dimensional radar backscatter map of the...

  12. Change detection in polarimetric SAR data over several time points

    DEFF Research Database (Denmark)

    Conradsen, Knut; Nielsen, Allan Aasbjerg; Skriver, Henning

    2014-01-01

    A test statistic for the equality of several variance-covariance matrices following the complex Wishart distribution is introduced. The test statistic is applied successfully to detect change in C-band EMISAR polarimetric SAR data over four time points....

  13. RAMP AMM-1 SAR Image Mosaic of Antarctica

    Data.gov (United States)

    National Aeronautics and Space Administration — In 1997, the Canadian RADARSAT-1 satellite was rotated in orbit so that its Synthetic Aperture Radar (SAR) antenna looked south towards Antarctica. This permitted...

  14. Reconstruction of interrupted SAR imagery for persistent surveillance change detection

    Science.gov (United States)

    Stojanovic, Ivana; Karl, W. C.; Novak, Les

    2012-05-01

    In this paper we apply a sparse signal recovery technique for synthetic aperture radar (SAR) image formation from interrupted phase history data. Timeline constraints imposed on multi-function modern radars result in interrupted SAR data collection, which in turn leads to corrupted imagery that degrades reliable change detection. In this paper we extrapolate the missing data by applying the basis pursuit denoising algorithm (BPDN) in the image formation step, effectively, modeling the SAR scene as sparse. We investigate the effects of regular and random interruptions on the SAR point spread function (PSF), as well as on the quality of both coherent (CCD) and non-coherent (NCCD) change detection. We contrast the sparse reconstruction to the matched filter (MF) method, implemented via Fourier processing with missing data set to zero. To illustrate the capabilities of the gap-filling sparse reconstruction algorithm, we evaluate change detection performance using a pair of images from the GOTCHA data set.

  15. Learning a Dilated Residual Network for SAR Image Despeckling

    Science.gov (United States)

    Zhang, Qiang; Yuan, Qiangqiang; Li, Jie; Yang, Zhen; Ma, Xiaoshuang

    2018-01-01

    In this paper, to break the limit of the traditional linear models for synthetic aperture radar (SAR) image despeckling, we propose a novel deep learning approach by learning a non-linear end-to-end mapping between the noisy and clean SAR images with a dilated residual network (SAR-DRN). SAR-DRN is based on dilated convolutions, which can both enlarge the receptive field and maintain the filter size and layer depth with a lightweight structure. In addition, skip connections and residual learning strategy are added to the despeckling model to maintain the image details and reduce the vanishing gradient problem. Compared with the traditional despeckling methods, the proposed method shows superior performance over the state-of-the-art methods on both quantitative and visual assessments, especially for strong speckle noise.

  16. Sliding Spotlight Mode Imaging with GF-3 Spaceborne SAR Sensor

    Directory of Open Access Journals (Sweden)

    Qingjun Zhang

    2017-12-01

    Full Text Available Synthetic aperture radar (SAR sliding spotlight work mode can achieve high resolutions and wide swath (HRWS simultaneously by steering the radar antenna beam. This paper aims to obtain well focused images using sliding spotlight mode with the Chinese Gaofen-3 SAR sensor. We proposed an integrated imaging scheme with sliding spotlight echoes. In the imaging scheme, the two-step approach is applied to the spaceborne sliding spotlight SAR imaging algorithm, followed by the Doppler parameter estimation algorithm. The azimuth spectral folding phenomenon is overcome by the two-step approach. The results demonstrate a high Doppler parameter estimation accuracy. The proposed imaging process is accurate and highly efficient for sliding spotlight SAR mode.

  17. An Objective Evaluation of Four SAR Image Segmentation Algorithms

    National Research Council Canada - National Science Library

    Gregga, Jason

    2001-01-01

    .... A key step towards automated SAR image analysis is image segmentation. There are many segmentation algorithms, but they have not been tested on a common set of images, and there are no standard test methods...

  18. Learning a Dilated Residual Network for SAR Image Despeckling

    Directory of Open Access Journals (Sweden)

    Qiang Zhang

    2018-01-01

    Full Text Available In this paper, to break the limit of the traditional linear models for synthetic aperture radar (SAR image despeckling, we propose a novel deep learning approach by learning a non-linear end-to-end mapping between the noisy and clean SAR images with a dilated residual network (SAR-DRN. SAR-DRN is based on dilated convolutions, which can both enlarge the receptive field and maintain the filter size and layer depth with a lightweight structure. In addition, skip connections and a residual learning strategy are added to the despeckling model to maintain the image details and reduce the vanishing gradient problem. Compared with the traditional despeckling methods, the proposed method shows a superior performance over the state-of-the-art methods in both quantitative and visual assessments, especially for strong speckle noise.

  19. Wavelet Filter Banks for Super-Resolution SAR Imaging

    Science.gov (United States)

    Sheybani, Ehsan O.; Deshpande, Manohar; Memarsadeghi, Nargess

    2011-01-01

    This paper discusses Innovative wavelet-based filter banks designed to enhance the analysis of super resolution Synthetic Aperture Radar (SAR) images using parametric spectral methods and signal classification algorithms, SAR finds applications In many of NASA's earth science fields such as deformation, ecosystem structure, and dynamics of Ice, snow and cold land processes, and surface water and ocean topography. Traditionally, standard methods such as Fast-Fourier Transform (FFT) and Inverse Fast-Fourier Transform (IFFT) have been used to extract Images from SAR radar data, Due to non-parametric features of these methods and their resolution limitations and observation time dependence, use of spectral estimation and signal pre- and post-processing techniques based on wavelets to process SAR radar data has been proposed. Multi-resolution wavelet transforms and advanced spectral estimation techniques have proven to offer efficient solutions to this problem.

  20. A beamforming algorithm for bistatic SAR image formation

    Science.gov (United States)

    Jakowatz, Charles V., Jr.; Wahl, Daniel E.; Yocky, David A.

    2010-04-01

    Beamforming is a methodology for collection-mode-independent SAR image formation. It is essentially equivalent to backprojection. The authors have in previous papers developed this idea and discussed the advantages and disadvantages of the approach to monostatic SAR image formation vis-à-vis the more standard and time-tested polar formatting algorithm (PFA). In this paper we show that beamforming for bistatic SAR imaging leads again to a very simple image formation algorithm that requires a minimal number of lines of code and that allows the image to be directly formed onto a three-dimensional surface model, thus automatically creating an orthorectified image. The same disadvantage of beamforming applied to monostatic SAR imaging applies to the bistatic case, however, in that the execution time for the beamforming algorithm is quite long compared to that of PFA. Fast versions of beamforming do exist to help alleviate this issue. Results of image reconstructions from phase history data are presented.

  1. A Stepped Frequency CW SAR for Lightweight UAV Operation

    National Research Council Canada - National Science Library

    Morrison, Keith

    2005-01-01

    A stepped-frequency continuous wave (SF-CW) synthetic aperture radar (SAR), with frequency-agile waveforms and real-time intelligent signal processing algorithms, is proposed for operation from a lightweight UAV platform...

  2. Genome organization of the SARS-CoV

    DEFF Research Database (Denmark)

    Xu, Jing; Hu, Jianfei; Wang, Jing

    2003-01-01

    Annotation of the genome sequence of the SARS-CoV (severe acute respiratory syndrome-associated coronavirus) is indispensable to understand its evolution and pathogenesis. We have performed a full annotation of the SARS-CoV genome sequences by using annotation programs publicly available or devel......Annotation of the genome sequence of the SARS-CoV (severe acute respiratory syndrome-associated coronavirus) is indispensable to understand its evolution and pathogenesis. We have performed a full annotation of the SARS-CoV genome sequences by using annotation programs publicly available...... regions. The analysis of TRS supports the minus strand extending transcription mechanism of coronavirus. The SNP analysis of different isolates reveals that mutations of the sequences do not affect the prediction results of ORFs. Udgivelsesdato: 2003-Aug...

  3. Mining Land Subsidence Monitoring Using SENTINEL-1 SAR Data

    Science.gov (United States)

    Yuan, W.; Wang, Q.; Fan, J.; Li, H.

    2017-09-01

    In this paper, DInSAR technique was used to monitor land subsidence in mining area. The study area was selected in the coal mine area located in Yuanbaoshan District, Chifeng City, and Sentinel-1 data were used to carry out DInSAR techniqu. We analyzed the interferometric results by Sentinel-1 data from December 2015 to May 2016. Through the comparison of the results of DInSAR technique and the location of the mine on the optical images, it is shown that DInSAR technique can be used to effectively monitor the land subsidence caused by underground mining, and it is an effective tool for law enforcement of over-mining.

  4. Massachusetts Bay - Internal wave packets digitized from SAR imagery

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This feature class contains internal wave packets digitized from SAR imagery at 1:350,000 scale in Massachusetts Bay. Internal waves are nonsinusoidal waves that...

  5. Object Georeferencing in UAV-Based SAR Terrain Images

    OpenAIRE

    Łabowski Michał; Kaniewski Piotr; Serafin Piotr; Wajszczyk Bronisław

    2016-01-01

    Synthetic aperture radars (SAR) allow to obtain high resolution terrain images comparable with the resolution of optical methods. Radar imaging is independent on the weather conditions and the daylight. The process of analysis of the SAR images consists primarily of identifying of interesting objects. The ability to determine their geographical coordinates can increase usability of the solution from a user point of view. The paper presents a georeferencing method of the radar terrain images. ...

  6. Comparing satellite SAR and wind farm wake models

    DEFF Research Database (Denmark)

    Hasager, Charlotte Bay; Vincent, P.; Husson, R.

    2015-01-01

    . These extend several tens of kilometres downwind e.g. 70 km. Other SAR wind maps show near-field fine scale details of wake behind rows of turbines. The satellite SAR wind farm wake cases are modelled by different wind farm wake models including the PARK microscale model, the Weather Research and Forecasting...... (WRF) model in high resolution and WRF with coupled microscale parametrization....

  7. Statistical SAR studies of windfields near Unimak Island

    Energy Technology Data Exchange (ETDEWEB)

    Smith, R.B.; Pan, F. [Yale Univ., New Haven, CT (United States)

    1997-06-01

    The modification of wind patterns by coastlines and islands is outlined. The paper focuses on methods for observing the sheltering effect, in which windspeed downwind of high terrain is reduced. Three observational methods are described: in situ observation, sunglint imagery using specular reflection, and synthetic-aperture radar (SAR). A data archive of SAR images of Unimak Island in the Aleutian Islands chain which was analyzed for sheltering effects is described.

  8. One carbon metabolism in SAR11 pelagic marine bacteria.

    Directory of Open Access Journals (Sweden)

    Jing Sun

    Full Text Available The SAR11 Alphaproteobacteria are the most abundant heterotrophs in the oceans and are believed to play a major role in mineralizing marine dissolved organic carbon. Their genomes are among the smallest known for free-living heterotrophic cells, raising questions about how they successfully utilize complex organic matter with a limited metabolic repertoire. Here we show that conserved genes in SAR11 subgroup Ia (Candidatus Pelagibacter ubique genomes encode pathways for the oxidation of a variety of one-carbon compounds and methyl functional groups from methylated compounds. These pathways were predicted to produce energy by tetrahydrofolate (THF-mediated oxidation, but not to support the net assimilation of biomass from C1 compounds. Measurements of cellular ATP content and the oxidation of (14C-labeled compounds to (14CO(2 indicated that methanol, formaldehyde, methylamine, and methyl groups from glycine betaine (GBT, trimethylamine (TMA, trimethylamine N-oxide (TMAO, and dimethylsulfoniopropionate (DMSP were oxidized by axenic cultures of the SAR11 strain Ca. P. ubique HTCC1062. Analyses of metagenomic data showed that genes for C1 metabolism occur at a high frequency in natural SAR11 populations. In short term incubations, natural communities of Sargasso Sea microbial plankton expressed a potential for the oxidation of (14C-labeled formate, formaldehyde, methanol and TMAO that was similar to cultured SAR11 cells and, like cultured SAR11 cells, incorporated a much larger percentage of pyruvate and glucose (27-35% than of C1 compounds (2-6% into biomass. Collectively, these genomic, cellular and environmental data show a surprising capacity for demethylation and C1 oxidation in SAR11 cultures and in natural microbial communities dominated by SAR11, and support the conclusion that C1 oxidation might be a significant conduit by which dissolved organic carbon is recycled to CO(2 in the upper ocean.

  9. sar vallejo's poetry: the paradigm of the rebellion

    OpenAIRE

    Lipnevičiūtė, Rolanda

    2016-01-01

    "César Vallejo's Poetry: the Paradigm of the Rebellion". The object of bachelor work „ César Vallejo' Poetry: the Paradigm of the Rebellion “ is the poetry of Peruvian poet Cesar Vallejo. The study aims to reveal the paradigm of the rebellion that was observed in three following aspects: the social rebellion, internal oppositions and arguments with the Bible. In order to conduct a survey the hermeneutic poetry analysis and sociocultural perspectives were used. According to the hypothesis form...

  10. The Danish (Q)SAR Database Update Project

    DEFF Research Database (Denmark)

    Nikolov, Nikolai Georgiev; Dybdahl, Marianne; Abildgaard Rosenberg, Sine

    2013-01-01

    The Danish (Q)SAR Database is a collection of predictions from quantitative structure–activity relationship ((Q)SAR) models for over 70 environmental and human health-related endpoints (covering biodegradation, metabolism, allergy, irritation, endocrine disruption, teratogenicity, mutagenicity, c...... will contain more than 600,000 discrete organic structures and new, more precise predictions for all endpoints, derived by consensus algorithms from a number of state-of-the-art individual predictions. Copyright © 2013 Published by Elsevier Ireland Ltd....

  11. Nano(Q)SAR: Challenges, pitfalls and perspectives.

    Science.gov (United States)

    Tantra, Ratna; Oksel, Ceyda; Puzyn, Tomasz; Wang, Jian; Robinson, Kenneth N; Wang, Xue Z; Ma, Cai Y; Wilkins, Terry

    2015-01-01

    Regulation for nanomaterials is urgently needed, and the drive to adopt an intelligent testing strategy is evident. Such a strategy will not only provide economic benefits but will also reduce moral and ethical concerns arising from animal testing. For regulatory purposes, such an approach is promoted by REACH, particularly the use of quantitative structure-activity relationships [(Q)SAR] as a tool for the categorisation of compounds according to their physicochemical and toxicological properties. In addition to compounds, (Q)SAR has also been applied to nanomaterials in the form of nano(Q)SAR. Although (Q)SAR in chemicals is well established, nano(Q)SAR is still in early stages of development and its successful uptake is far from reality. This article aims to identify some of the pitfalls and challenges associated with nano-(Q)SARs in relation to the categorisation of nanomaterials. Our findings show clear gaps in the research framework that must be addressed if we are to have reliable predictions from such models. Three major barriers were identified: the need to improve quality of experimental data in which the models are developed from, the need to have practical guidelines for the development of the nano(Q)SAR models and the need to standardise and harmonise activities for the purpose of regulation. Of these three, the first, i.e. the need to improve data quality requires immediate attention, as it underpins activities associated with the latter two. It should be noted that the usefulness of data in the context of nano-(Q)SAR modelling is not only about the quantity of data but also about the quality, consistency and accessibility of those data.

  12. Pulse-based internal calibration of polarimetric SAR

    DEFF Research Database (Denmark)

    Dall, Jørgen; Skou, Niels; Christensen, Erik Lintz

    1994-01-01

    Internal calibration greatly diminishes the dependence on calibration target deployment compared to external calibration. Therefore the Electromagnetics Institute (EMI) at the Technical University of Denmark (TUD) has equipped its polarimetric SAR, EMISAR, with several calibration loops and devel......Internal calibration greatly diminishes the dependence on calibration target deployment compared to external calibration. Therefore the Electromagnetics Institute (EMI) at the Technical University of Denmark (TUD) has equipped its polarimetric SAR, EMISAR, with several calibration loops...

  13. [Factors of avascular necrosis of femoral head and osteoporosis in SARS patients' convalescence].

    Science.gov (United States)

    Li, Yu-ming; Wang, Shi-xin; Gao, Hong-sheng; Wang, Jing-gui; Wei, Chuan-she; Chen, Li-ming; Hui, Wu-li; Yuan, Shu-ling; Jiao, Zhen-shan; Yang, Zhen; Su, Bin

    2004-08-17

    head and osteoporosis. The incidence rates of avascular necrosis of femoral head and of osteoporosis were higher in convalescent SARS patients than in general population. The influencing factors of femoral necrosis included the degree of healing activity, the dosage summation of corticosteroids, and length of ictus therapy. The influencing factors of bone density included age, dosage summation, and length of ictus therapy. The influencing factors of the bone fabric and flexibility included the use and length of ictus therapy. Statistics showed that serum IgG was not related with avascular necrosis of femoral head and osteoporosis. SARS virus may not affect the pathogenesis of avascular necrosis of femoral head and osteoporosis.

  14. Evaluation of Polarimetric SAR Decomposition for Classifying Wetland Vegetation Types

    Directory of Open Access Journals (Sweden)

    Sang-Hoon Hong

    2015-07-01

    Full Text Available The Florida Everglades is the largest subtropical wetland system in the United States and, as with subtropical and tropical wetlands elsewhere, has been threatened by severe environmental stresses. It is very important to monitor such wetlands to inform management on the status of these fragile ecosystems. This study aims to examine the applicability of TerraSAR-X quadruple polarimetric (quad-pol synthetic aperture radar (PolSAR data for classifying wetland vegetation in the Everglades. We processed quad-pol data using the Hong & Wdowinski four-component decomposition, which accounts for double bounce scattering in the cross-polarization signal. The calculated decomposition images consist of four scattering mechanisms (single, co- and cross-pol double, and volume scattering. We applied an object-oriented image analysis approach to classify vegetation types with the decomposition results. We also used a high-resolution multispectral optical RapidEye image to compare statistics and classification results with Synthetic Aperture Radar (SAR observations. The calculated classification accuracy was higher than 85%, suggesting that the TerraSAR-X quad-pol SAR signal had a high potential for distinguishing different vegetation types. Scattering components from SAR acquisition were particularly advantageous for classifying mangroves along tidal channels. We conclude that the typical scattering behaviors from model-based decomposition are useful for discriminating among different wetland vegetation types.

  15. URBAN MODELLING PERFORMANCE OF NEXT GENERATION SAR MISSIONS

    Directory of Open Access Journals (Sweden)

    U. G. Sefercik

    2017-09-01

    Full Text Available In synthetic aperture radar (SAR technology, urban mapping and modelling have become possible with revolutionary missions TerraSAR-X (TSX and Cosmo-SkyMed (CSK since 2007. These satellites offer 1m spatial resolution in high-resolution spotlight imaging mode and capable for high quality digital surface model (DSM acquisition for urban areas utilizing interferometric SAR (InSAR technology. With the advantage of independent generation from seasonal weather conditions, TSX and CSK DSMs are much in demand by scientific users. The performance of SAR DSMs is influenced by the distortions such as layover, foreshortening, shadow and double-bounce depend up on imaging geometry. In this study, the potential of DSMs derived from convenient 1m high-resolution spotlight (HS InSAR pairs of CSK and TSX is validated by model-to-model absolute and relative accuracy estimations in an urban area. For the verification, an airborne laser scanning (ALS DSM of the study area was used as the reference model. Results demonstrated that TSX and CSK urban DSMs are compatible in open, built-up and forest land forms with the absolute accuracy of 8–10 m. The relative accuracies based on the coherence of neighbouring pixels are superior to absolute accuracies both for CSK and TSX.

  16. Using SAR satellite data time series for regional glacier mapping

    Directory of Open Access Journals (Sweden)

    S. H. Winsvold

    2018-03-01

    Full Text Available With dense SAR satellite data time series it is possible to map surface and subsurface glacier properties that vary in time. On Sentinel-1A and RADARSAT-2 backscatter time series images over mainland Norway and Svalbard, we outline how to map glaciers using descriptive methods. We present five application scenarios. The first shows potential for tracking transient snow lines with SAR backscatter time series and correlates with both optical satellite images (Sentinel-2A and Landsat 8 and equilibrium line altitudes derived from in situ surface mass balance data. In the second application scenario, time series representation of glacier facies corresponding to SAR glacier zones shows potential for a more accurate delineation of the zones and how they change in time. The third application scenario investigates the firn evolution using dense SAR backscatter time series together with a coupled energy balance and multilayer firn model. We find strong correlation between backscatter signals with both the modeled firn air content and modeled wetness in the firn. In the fourth application scenario, we highlight how winter rain events can be detected in SAR time series, revealing important information about the area extent of internal accumulation. In the last application scenario, averaged summer SAR images were found to have potential in assisting the process of mapping glaciers outlines, especially in the presence of seasonal snow. Altogether we present examples of how to map glaciers and to further understand glaciological processes using the existing and future massive amount of multi-sensor time series data.

  17. Using SAR satellite data time series for regional glacier mapping

    Science.gov (United States)

    Winsvold, Solveig H.; Kääb, Andreas; Nuth, Christopher; Andreassen, Liss M.; van Pelt, Ward J. J.; Schellenberger, Thomas

    2018-03-01

    With dense SAR satellite data time series it is possible to map surface and subsurface glacier properties that vary in time. On Sentinel-1A and RADARSAT-2 backscatter time series images over mainland Norway and Svalbard, we outline how to map glaciers using descriptive methods. We present five application scenarios. The first shows potential for tracking transient snow lines with SAR backscatter time series and correlates with both optical satellite images (Sentinel-2A and Landsat 8) and equilibrium line altitudes derived from in situ surface mass balance data. In the second application scenario, time series representation of glacier facies corresponding to SAR glacier zones shows potential for a more accurate delineation of the zones and how they change in time. The third application scenario investigates the firn evolution using dense SAR backscatter time series together with a coupled energy balance and multilayer firn model. We find strong correlation between backscatter signals with both the modeled firn air content and modeled wetness in the firn. In the fourth application scenario, we highlight how winter rain events can be detected in SAR time series, revealing important information about the area extent of internal accumulation. In the last application scenario, averaged summer SAR images were found to have potential in assisting the process of mapping glaciers outlines, especially in the presence of seasonal snow. Altogether we present examples of how to map glaciers and to further understand glaciological processes using the existing and future massive amount of multi-sensor time series data.

  18. Urban Modelling Performance of Next Generation SAR Missions

    Science.gov (United States)

    Sefercik, U. G.; Yastikli, N.; Atalay, C.

    2017-09-01

    In synthetic aperture radar (SAR) technology, urban mapping and modelling have become possible with revolutionary missions TerraSAR-X (TSX) and Cosmo-SkyMed (CSK) since 2007. These satellites offer 1m spatial resolution in high-resolution spotlight imaging mode and capable for high quality digital surface model (DSM) acquisition for urban areas utilizing interferometric SAR (InSAR) technology. With the advantage of independent generation from seasonal weather conditions, TSX and CSK DSMs are much in demand by scientific users. The performance of SAR DSMs is influenced by the distortions such as layover, foreshortening, shadow and double-bounce depend up on imaging geometry. In this study, the potential of DSMs derived from convenient 1m high-resolution spotlight (HS) InSAR pairs of CSK and TSX is validated by model-to-model absolute and relative accuracy estimations in an urban area. For the verification, an airborne laser scanning (ALS) DSM of the study area was used as the reference model. Results demonstrated that TSX and CSK urban DSMs are compatible in open, built-up and forest land forms with the absolute accuracy of 8-10 m. The relative accuracies based on the coherence of neighbouring pixels are superior to absolute accuracies both for CSK and TSX.

  19. InSAR deformation monitoring of high risk landslides

    Science.gov (United States)

    Singhroy, V.; Li, J.

    2013-05-01

    During the past year there were at least twenty five media reports of landslides and seismic activities some fatal, occurring in various areas in Canada. These high risk geohazards sites requires high resolution monitoring both spatially and temporally for mitigation purposes, since they are near populated areas and energy, transportation and communication corridors. High resolution air photos, lidar and satellite images are quite common in areas where the landslides can be fatal. Radar interferometry (InSAR) techniques using images from several radar satellites are increasingly being used in slope stability assessment. This presentation provides examples of using high-resolution (1-3m) frequent revisits InSAR techniques from RADARSAT 2 and TerraSAR X to monitor several types of high-risk landslides affecting transportation and energy corridors and populated areas. We have analyses over 200 high resolution InSAR images over a three year period on geologically different landslides. The high-resolution InSAR images are effective in characterizing differential motion within these low velocity landslides. The low velocity landslides become high risk during the active wet spring periods. The wet soils are poor coherent targets and corner reflectors provide an effective means of InSAR monitoring the slope activities.

  20. Improved SAR Image Coregistration Using Pixel-Offset Series

    KAUST Repository

    Wang, Teng

    2014-03-14

    Synthetic aperture radar (SAR) image coregistration is a key procedure before interferometric SAR (InSAR) time-series analysis can be started. However, many geophysical data sets suffer from severe decorrelation problems due to a variety of reasons, making precise coregistration a nontrivial task. Here, we present a new strategy that uses a pixel-offset series of detected subimage patches dominated by point-like targets (PTs) to improve SAR image coregistrations. First, all potentially coherent image pairs are coregistered in a conventional way. In this step, we propose a coregistration quality index for each image to rank its relative “significance” within the data set and to select a reference image for the SAR data set. Then, a pixel-offset series of detected PTs is made from amplitude maps to improve the geometrical mapping functions. Finally, all images are resampled depending on the pixel offsets calculated from the updated geometrical mapping functions. We used images from a rural region near the North Anatolian Fault in eastern Turkey to test the proposed method, and clear coregistration improvements were found based on amplitude stability. This enhanced the fact that the coregistration strategy should therefore lead to improved InSAR time-series analysis results.

  1. The utility of SAR to monitor ocean processes

    Science.gov (United States)

    Shuchman, R. A.; Kasischke, E. S.; Meadows, G. A.; Lyden, J. D.; Lyzenga, D. R.; Jackson, P. L.; Maffett, A. L.; Klooster, A., Jr.

    1981-11-01

    This report investigates the utility of using synthetic aperture radar (SAR) to monitor the Earth's oceans. The report consists of three parts which include: (1) a review on the present capability of SARs to monitor ocean processes, (2) a status report on the processing and preliminary analysis of UPD-4 and UPD-6 data collected during the MARSEN'79 Experiment, and (3) a collection of journal articles and symposia papers which resulted from this ONR-funded ERIM research. The review of the present status of SAR's utility to monitor the oceans includes the detection and measurement of gravity waves, currents, long-period waves, internal waves, frontal boundaries, bottom topographic features, surface winds, surf zone conditions, oil slicks, and sea ice. Results of this analysis indicate the UPD-4 X-band SAR imagery is not significantly improved, with regard to visibility of waves on the imagery when motion compensation adjustments are incorporated into the processing of the SAR signal histories. Selected passes of UPD-4 and UPD-6 X-band imagery have been digitized and comparisons between SAR generated wave spectra and surface measured spectra were made.

  2. Scattering property based contextual PolSAR speckle filter

    Science.gov (United States)

    Mullissa, Adugna G.; Tolpekin, Valentyn; Stein, Alfred

    2017-12-01

    Reliability of the scattering model based polarimetric SAR (PolSAR) speckle filter depends upon the accurate decomposition and classification of the scattering mechanisms. This paper presents an improved scattering property based contextual speckle filter based upon an iterative classification of the scattering mechanisms. It applies a Cloude-Pottier eigenvalue-eigenvector decomposition and a fuzzy H/α classification to determine the scattering mechanisms on a pre-estimate of the coherency matrix. The H/α classification identifies pixels with homogeneous scattering properties. A coarse pixel selection rule groups pixels that are either single bounce, double bounce or volume scatterers. A fine pixel selection rule is applied to pixels within each canonical scattering mechanism. We filter the PolSAR data and depending on the type of image scene (urban or rural) use either the coarse or fine pixel selection rule. Iterative refinement of the Wishart H/α classification reduces the speckle in the PolSAR data. Effectiveness of this new filter is demonstrated by using both simulated and real PolSAR data. It is compared with the refined Lee filter, the scattering model based filter and the non-local means filter. The study concludes that the proposed filter compares favorably with other polarimetric speckle filters in preserving polarimetric information, point scatterers and subtle features in PolSAR data.

  3. Importance of rabies virus nucleoprotein in viral evasion of interferon response in the brain.

    Science.gov (United States)

    Masatani, Tatsunori; Ito, Naoto; Ito, Yuki; Nakagawa, Keisuke; Abe, Masako; Yamaoka, Satoko; Okadera, Kota; Sugiyama, Makoto

    2013-07-01

    By using a cultured neuroblastoma cell line, the present authors recently showed that the N protein of virulent rabies virus fixed strain Nishigahara (Ni), but not that of the attenuated derivative Ni-CE, mediates evasion of induction of type I interferon (IFN). In this study, to determine whether Ni N protein indeed fulfills this function in vivo, the abilities to suppress IFN responses in the mouse brain of Ni-CE and the virulent chimeric virus CE(NiN), which has the N gene from Ni in the genetic background of Ni-CE, were compared. It was demonstrated that CE(NiN) propagates and spreads more efficiently than does Ni-CE in the brain and that IFN response in brains infected with CE(NiN) is weaker than in those infected with Ni-CE. It was also shown that amino acids at positions 273 and 394 in the N protein, which are known as pathogenic determinants, affect the ability of the viruses to suppress IFN response in the brain. These findings strongly suggest that, in the brain, rabies virus N protein plays important roles in evasion of innate immune responses and thereby in efficient propagation and spread of virus leading to lethal outcomes of infection. © 2013 The Societies and Wiley Publishing Asia Pty Ltd.

  4. Analysis of intraviral protein-protein interactions of the SARS coronavirus ORFeome.

    Directory of Open Access Journals (Sweden)

    Albrecht von Brunn

    2007-05-01

    Full Text Available The severe acute respiratory syndrome coronavirus (SARS-CoV genome is predicted to encode 14 functional open reading frames, leading to the expression of up to 30 structural and non-structural protein products. The functions of a large number of viral ORFs are poorly understood or unknown. In order to gain more insight into functions and modes of action and interaction of the different proteins, we cloned the viral ORFeome and performed a genome-wide analysis for intraviral protein interactions and for intracellular localization. 900 pairwise interactions were tested by yeast-two-hybrid matrix analysis, and more than 65 positive non-redundant interactions, including six self interactions, were identified. About 38% of interactions were subsequently confirmed by CoIP in mammalian cells. Nsp2, nsp8 and ORF9b showed a wide range of interactions with other viral proteins. Nsp8 interacts with replicase proteins nsp2, nsp5, nsp6, nsp7, nsp8, nsp9, nsp12, nsp13 and nsp14, indicating a crucial role as a major player within the replication complex machinery. It was shown by others that nsp8 is essential for viral replication in vitro, whereas nsp2 is not. We show that also accessory protein ORF9b does not play a pivotal role for viral replication, as it can be deleted from the virus displaying normal plaque sizes and growth characteristics in Vero cells. However, it can be expected to be important for the virus-host interplay and for pathogenicity, due to its large number of interactions, by enhancing the global stability of the SARS proteome network, or play some unrealized role in regulating protein-protein interactions. The interactions identified provide valuable material for future studies.

  5. G0/G1 arrest and apoptosis induced by SARS-CoV 3b protein in transfected cells

    Directory of Open Access Journals (Sweden)

    Chen Jiapei

    2005-08-01

    Full Text Available Abstract Severe Acute Respiratory Syndrome coronavirus (SARS-CoV, cause of the life-threatening atypical pneumonia, infects many organs, such as lung, liver and immune organ, and induces parenchyma cells apoptosis and necrosis. The genome of SARS-CoV, not closely related to any of the previously characterized coronavirus, encodes replicase and four major structural proteins and a number of non-structural proteins. Published studies suggest that some non-structural proteins may play important roles in the replication, virulence and pathogenesis of viruses. Among the potential SARS-CoV non-structural proteins, 3b protein (ORF4 is predicted encoding 154 amino acids, lacking significant similarities to any known proteins. Till now, there is no report about the function of 3b protein. In this study, 3b gene was linked with the EGFP tag at the C- terminus. Through cell cycle analysis, it was found that over-expression of 3b-EGFP protein in Vero, 293 and COS-7 cells could induce cell cycle arrest at G0/G1 phase, and that especially in COS-7 cells, expression of 3b-EGFP was able to induce the increase of sub-G1 phase from 24 h after transfection, which was most obvious at 48 h. The apoptosis induction of 3b fusion protein in COS-7 cells was further confirmed by double cell labeling with 7-AAD and Annexin V, the function of 3b protein inducing cell G0/G1 arrest and apoptosis may provide a new insight for further study on the mechanism of SARS pathogenesis.

  6. InSAR Scientific Computing Environment

    Science.gov (United States)

    Rosen, Paul A.; Sacco, Gian Franco; Gurrola, Eric M.; Zabker, Howard A.

    2011-01-01

    This computing environment is the next generation of geodetic image processing technology for repeat-pass Interferometric Synthetic Aperture (InSAR) sensors, identified by the community as a needed capability to provide flexibility and extensibility in reducing measurements from radar satellites and aircraft to new geophysical products. This software allows users of interferometric radar data the flexibility to process from Level 0 to Level 4 products using a variety of algorithms and for a range of available sensors. There are many radar satellites in orbit today delivering to the science community data of unprecedented quantity and quality, making possible large-scale studies in climate research, natural hazards, and the Earth's ecosystem. The proposed DESDynI mission, now under consideration by NASA for launch later in this decade, would provide time series and multiimage measurements that permit 4D models of Earth surface processes so that, for example, climate-induced changes over time would become apparent and quantifiable. This advanced data processing technology, applied to a global data set such as from the proposed DESDynI mission, enables a new class of analyses at time and spatial scales unavailable using current approaches. This software implements an accurate, extensible, and modular processing system designed to realize the full potential of InSAR data from future missions such as the proposed DESDynI, existing radar satellite data, as well as data from the NASA UAVSAR (Uninhabited Aerial Vehicle Synthetic Aperture Radar), and other airborne platforms. The processing approach has been re-thought in order to enable multi-scene analysis by adding new algorithms and data interfaces, to permit user-reconfigurable operation and extensibility, and to capitalize on codes already developed by NASA and the science community. The framework incorporates modern programming methods based on recent research, including object-oriented scripts controlling legacy and

  7. First Spaceborne SAR-GMTI Experimental Results for the Chinese Gaofen-3 Dual-Channel SAR Sensor.

    Science.gov (United States)

    Wang, Chenghao; Liao, Guisheng; Zhang, Qingjun

    2017-11-21

    In spaceborne synthetic aperture radar (SAR) sensors, it is a challenging task to detect ground slow-moving targets against strong clutter background with limited spatial channels and restricted pulse repetition frequency (PRF). In this paper, we evaluate the image-based dual-channel SAR-ground moving target indication (SAR-GMTI) workflow for the Gaofen-3 SAR sensor and analyze the impact of strong azimuth ambiguities on GMTI when the displaced phase center antenna (DPCA) condition is not fully satisfied, which has not been demonstrated yet. An effective sliding window design technique based on system parameters analysis is proposed to deal with azimuth ambiguities and reduce false alarm. In the SAR-GMTI experiments, co-registration, clutter suppression, constant false alarm rate (CFAR) detector, vector velocity estimation and moving target relocation are analyzed and discussed thoroughly. With the real measured data of the Gaofen-3 dual-channel SAR sensor, the GMTI capability of this sensor is demonstrated and the effectiveness of the proposed method is verified.

  8. First Spaceborne SAR-GMTI Experimental Results for the Chinese Gaofen-3 Dual-Channel SAR Sensor

    Directory of Open Access Journals (Sweden)

    Chenghao Wang

    2017-11-01

    Full Text Available In spaceborne synthetic aperture radar (SAR sensors, it is a challenging task to detect ground slow-moving targets against strong clutter background with limited spatial channels and restricted pulse repetition frequency (PRF. In this paper, we evaluate the image-based dual-channel SAR-ground moving target indication (SAR-GMTI workflow for the Gaofen-3 SAR sensor and analyze the impact of strong azimuth ambiguities on GMTI when the displaced phase center antenna (DPCA condition is not fully satisfied, which has not been demonstrated yet. An effective sliding window design technique based on system parameters analysis is proposed to deal with azimuth ambiguities and reduce false alarm. In the SAR-GMTI experiments, co-registration, clutter suppression, constant false alarm rate (CFAR detector, vector velocity estimation and moving target relocation are analyzed and discussed thoroughly. With the real measured data of the Gaofen-3 dual-channel SAR sensor, the GMTI capability of this sensor is demonstrated and the effectiveness of the proposed method is verified.

  9. Global Rapid Flood Mapping System with Spaceborne SAR Data

    Science.gov (United States)

    Yun, S. H.; Owen, S. E.; Hua, H.; Agram, P. S.; Fattahi, H.; Liang, C.; Manipon, G.; Fielding, E. J.; Rosen, P. A.; Webb, F.; Simons, M.

    2017-12-01

    As part of the Advanced Rapid Imaging and Analysis (ARIA) project for Natural Hazards, at NASA's Jet Propulsion Laboratory and California Institute of Technology, we have developed an automated system that produces derived products for flood extent map generation using spaceborne SAR data. The system takes user's input of area of interest polygons and time window for SAR data search (pre- and post-event). Then the system automatically searches and downloads SAR data, processes them to produce coregistered SAR image pairs, and generates log amplitude ratio images from each pair. Currently the system is automated to support SAR data from the European Space Agency's Sentinel-1A/B satellites. We have used the system to produce flood extent maps from Sentinel-1 SAR data for the May 2017 Sri Lanka floods, which killed more than 200 people and displaced about 600,000 people. Our flood extent maps were delivered to the Red Cross to support response efforts. Earlier we also responded to the historic August 2016 Louisiana floods in the United States, which claimed 13 people's lives and caused over $10 billion property damage. For this event, we made synchronized observations from space, air, and ground in close collaboration with USGS and NOAA. The USGS field crews acquired ground observation data, and NOAA acquired high-resolution airborne optical imagery within the time window of +/-2 hours of the SAR data acquisition by JAXA's ALOS-2 satellite. The USGS coordinates of flood water boundaries were used to calibrate our flood extent map derived from the ALOS-2 SAR data, and the map was delivered to FEMA for estimating the number of households affected. Based on the lessons learned from this response effort, we customized the ARIA system automation for rapid flood mapping and developed a mobile friendly web app that can easily be used in the field for data collection. Rapid automatic generation of SAR-based global flood maps calibrated with independent observations from

  10. Message concerning Severe Acute Respiratory Syndrome ("SARS")

    CERN Multimedia

    2003-01-01

    IMPORTANT REMINDER If you have just come back from one of the regions identified by the WHO as being infected with SARS, it is essential to monitor your state of health for ten days after your return. The syndrome manifests itself in the rapid onset of a high fever combined with respiratory problems (coughing, breathlessness, breathing difficulty). Should these signs appear, you must contact the CERN Medical Service as quickly as possible on number 73802 or 73186 during normal working hours, and the fire brigade at all other times on number 74444, indicating that you have just returned from one of the WHO-identified areas with recent local transmission.China: Beijing, Hong Kong (Special Administrative Region), Guangdong Province, Inner Mongolia, Shanxi Province, Tianjin ProvinceTaiwan:TaipeiMoreover, until further notice the CERN Management requests that all trips to these various regions of the world be reduced to a strict minimum and then only with the consent of the Division Leader concerned. Anyone comin...

  11. Mitigating illumination gradients in a SAR image based on the image data and antenna beam pattern

    Science.gov (United States)

    Doerry, Armin W.

    2013-04-30

    Illumination gradients in a synthetic aperture radar (SAR) image of a target can be mitigated by determining a correction for pixel values associated with the SAR image. This correction is determined based on information indicative of a beam pattern used by a SAR antenna apparatus to illuminate the target, and also based on the pixel values associated with the SAR image. The correction is applied to the pixel values associated with the SAR image to produce corrected pixel values that define a corrected SAR image.

  12. Generation of interferogram for D-InSAR based on contoured correlation interferometry

    Science.gov (United States)

    Long, Xuejun; Fu, Sihua; Yu, Qifeng; Yang, Xia

    2009-10-01

    Synthetic Aperture Radar interferometry (InSAR) is a rapidly developing technique for earth observation. Differential InSAR (D-InSAR) technique, based on InSAR, is a new method for earthquake deformation detection and land subsidence monitoring. In this paper, an innovative method of generation of interferogram for D-InSAR based on contoured correlation interferometry (CCI) is presented, which may directly generate interferogram with almost no speckle noise or blurring. The data processing results of the Mani earthquake indicate that D-InSAR CCI method can effectively reduce or even remove the decorrelation noise, even in the area with serious decorrelation.

  13. Tandem-L: Monitoring the Earth's Dynamics with InSAR and Pol-InSAR

    Science.gov (United States)

    Moriera, A.; Hajnsek, I.; Krieger, G.; Papathanassiou, K.; Eineder, M.; De Zan, F.; Younis, M.; Werner, M.

    2009-04-01

    Tandem-L is a German mission proposal for an innovative interferometric L-band radar mission that enables the systematic monitoring of dynamic Earth processes using advanced techniques and technologies. The mission is science driven aiming to provide a unique data set for climate and environmental research, geodynamics, hydrology and oceanography. Important application examples are global forest height and biomass inventories, measurements of Earth deformation due to tectonic processes and/or anthropogenic factors, observations of ice/glacier velocity field and 3-D structure changes, and the monitoring of ocean surface currents. The Tandem-L mission concept consists of two cooperating satellites flying in close formation. The Pol-InSAR and repeat-pass acquisition modes provide a unique data source to observe, analyse and quantify a wide range of mutually interacting processes in the bio-, litho-, hydro- and cryosphere. The systematic observation of these processes benefits from the high data acquisition capacity and the novel high-resolution wide-swath SAR imaging modes that combine digital beamforming with a large reflector antenna. This paper provides an overview of the Tandem-L mission concept and its main application areas.

  14. Flood extent and water level estimation from SAR using data-model integration

    Science.gov (United States)

    Ajadi, O. A.; Meyer, F. J.

    2017-12-01

    Synthetic Aperture Radar (SAR) images have long been recognized as a valuable data source for flood mapping. Compared to other sources, SAR's weather and illumination independence and large area coverage at high spatial resolution supports reliable, frequent, and detailed observations of developing flood events. Accordingly, SAR has the potential to greatly aid in the near real-time monitoring of natural hazards, such as flood detection, if combined with automated image processing. This research works towards increasing the reliability and temporal sampling of SAR-derived flood hazard information by integrating information from multiple SAR sensors and SAR modalities (images and Interferometric SAR (InSAR) coherence) and by combining SAR-derived change detection information with hydrologic and hydraulic flood forecast models. First, the combination of multi-temporal SAR intensity images and coherence information for generating flood extent maps is introduced. The application of least-squares estimation integrates flood information from multiple SAR sensors, thus increasing the temporal sampling. SAR-based flood extent information will be combined with a Digital Elevation Model (DEM) to reduce false alarms and to estimate water depth and flood volume. The SAR-based flood extent map is assimilated into the Hydrologic Engineering Center River Analysis System (Hec-RAS) model to aid in hydraulic model calibration. The developed technology is improving the accuracy of flood information by exploiting information from data and models. It also provides enhanced flood information to decision-makers supporting the response to flood extent and improving emergency relief efforts.

  15. Satellite SAR interferometric techniques applied to emergency mapping

    Science.gov (United States)

    Stefanova Vassileva, Magdalena; Riccardi, Paolo; Lecci, Daniele; Giulio Tonolo, Fabio; Boccardo Boccardo, Piero; Chiesa, Giuliana; Angeluccetti, Irene

    2017-04-01

    This paper aim to investigate the capabilities of the currently available SAR interferometric algorithms in the field of emergency mapping. Several tests have been performed exploiting the Copernicus Sentinel-1 data using the COTS software ENVI/SARscape 5.3. Emergency Mapping can be defined as "creation of maps, geo-information products and spatial analyses dedicated to providing situational awareness emergency management and immediate crisis information for response by means of extraction of reference (pre-event) and crisis (post-event) geographic information/data from satellite or aerial imagery". The conventional differential SAR interferometric technique (DInSAR) and the two currently available multi-temporal SAR interferometric approaches, i.e. Permanent Scatterer Interferometry (PSI) and Small BAseline Subset (SBAS), have been applied to provide crisis information useful for the emergency management activities. Depending on the considered Emergency Management phase, it may be distinguished between rapid mapping, i.e. fast provision of geospatial data regarding the area affected for the immediate emergency response, and monitoring mapping, i.e. detection of phenomena for risk prevention and mitigation activities. In order to evaluate the potential and limitations of the aforementioned SAR interferometric approaches for the specific rapid and monitoring mapping application, five main factors have been taken into account: crisis information extracted, input data required, processing time and expected accuracy. The results highlight that DInSAR has the capacity to delineate areas affected by large and sudden deformations and fulfills most of the immediate response requirements. The main limiting factor of interferometry is the availability of suitable SAR acquisition immediately after the event (e.g. Sentinel-1 mission characterized by 6-day revisiting time may not always satisfy the immediate emergency request). PSI and SBAS techniques are suitable to produce

  16. Seasonal Inundation Monitoring of Northern Pantanal Wetland, Brazil Using ALOS SAR/InSAR and Envisat Altimetry

    Science.gov (United States)

    Kim, J.; Calmant, S.; Lee, H.; Lu, Z.; Shum, C.

    2011-12-01

    The Pantanal is one of the most biologically diverse ecosystems and largest wetland in the world. It has been threatened by massive economic development, and anthropogenic climate change. At the current rate, the Brazilian Pantanal will disappear within 45 years, according to 2006 report by Conservation International. Here, we illustrate that the evolutions of the Pantanal can be characterized by using ALOS PALSAR Fine-Beam and ScanSAR mode images, and Envisat radar altimetry. Multi-mode of high resolution and large-scale SAR images were used to unveil temporal and spatial inundation patterns. The backscattering coefficient of multi-mode SAR images shows regular change pattern in response to periodic inundation. InSAR analysis allows us to recognize that the temporal variation is not spatially constant, which is distinct among other wetlands, e.g., Louisiana wetlands. In addition to SAR/InSAR data, radar Altimetry (Envisat) is critical for providing vertical datum and fine temporal resolution, towards characterization of the Pantanal wetland condition during inundation. The observed close correlation between inundation area from SAR images and hydraulic change from a river gauge implies that the Pantanal is vulnerable to external effects presumably by human activities, and abnormal hydraulic change can threaten the ecosystems and biological diversity. We conclude that radar remote sensing data can provide timely and high-resolution monitoring of hydraulic characteristics of the Pantanal, one of the least-known and most fragile wetlands, and they can potentially be used as an efficient tool for remote wetland monitoring and ecological studies.

  17. Detecting and monitoring UCG subsidence with InSAR

    Energy Technology Data Exchange (ETDEWEB)

    Mellors, R J; Foxall, W; Yang, X

    2012-03-23

    The use of interferometric synthetic aperture radar (InSAR) to measure surface subsidence caused by Underground Coal Gasification (UCG) is tested. InSAR is a remote sensing technique that uses Synthetic Aperture Radar images to make spatial images of surface deformation and may be deployed from satellite or an airplane. With current commercial satellite data, the technique works best in areas with little vegetation or farming activity. UCG subsidence is generally caused by roof collapse, which adversely affects UCG operations due to gas loss and is therefore important to monitor. Previous studies have demonstrated the usefulness of InSAR in measuring surface subsidence related to coal mining and surface deformation caused by a coal mining roof collapse in Crandall Canyon, Utah is imaged as a proof-of-concept. InSAR data is collected and processed over three known UCG operations including two pilot plants (Majuba, South Africa and Wulanchabu, China) and an operational plant (Angren, Uzbekistan). A clear f eature showing approximately 7 cm of subsidence is observed in the UCG field in Angren. Subsidence is not observed in the other two areas, which produce from deeper coal seams and processed a smaller volume. The results show that in some cases, InSAR is a useful tool to image UCG related subsidence. Data from newer satellites and improved algorithms will improve effectiveness.

  18. Fast Superpixel Segmentation Algorithm for PolSAR Images

    Directory of Open Access Journals (Sweden)

    Zhang Yue

    2017-10-01

    Full Text Available As a pre-processing technique, superpixel segmentation algorithms should be of high computational efficiency, accurate boundary adherence and regular shape in homogeneous regions. A fast superpixel segmentation algorithm based on Iterative Edge Refinement (IER has shown to be applicable on optical images. However, it is difficult to obtain the ideal results when IER is applied directly to PolSAR images due to the speckle noise and small or slim regions in PolSAR images. To address these problems, in this study, the unstable pixel set is initialized as all the pixels in the PolSAR image instead of the initial grid edge pixels. In the local relabeling of the unstable pixels, the fast revised Wishart distance is utilized instead of the Euclidean distance in CIELAB color space. Then, a post-processing procedure based on dissimilarity measure is empolyed to remove isolated small superpixels as well as to retain the strong point targets. Finally, extensive experiments based on a simulated image and a real-world PolSAR image from Airborne Synthetic Aperture Radar (AirSAR are conducted, showing that the proposed algorithm, compared with three state-of-the-art methods, performs better in terms of several commonly used evaluation criteria with high computational efficiency, accurate boundary adherence, and homogeneous regularity.

  19. Modified Polar-Format Software for Processing SAR Data

    Science.gov (United States)

    Chen, Curtis

    2003-01-01

    HMPF is a computer program that implements a modified polar-format algorithm for processing data from spaceborne synthetic-aperture radar (SAR) systems. Unlike prior polar-format processing algorithms, this algorithm is based on the assumption that the radar signal wavefronts are spherical rather than planar. The algorithm provides for resampling of SAR pulse data from slant range to radial distance from the center of a reference sphere that is nominally the local Earth surface. Then, invoking the projection-slice theorem, the resampled pulse data are Fourier-transformed over radial distance, arranged in the wavenumber domain according to the acquisition geometry, resampled to a Cartesian grid, and inverse-Fourier-transformed. The result of this process is the focused SAR image. HMPF, and perhaps other programs that implement variants of the algorithm, may give better accuracy than do prior algorithms for processing strip-map SAR data from high altitudes and may give better phase preservation relative to prior polar-format algorithms for processing spotlight-mode SAR data.

  20. G0-WISHART Distribution Based Classification from Polarimetric SAR Images

    Science.gov (United States)

    Hu, G. C.; Zhao, Q. H.

    2017-09-01

    Enormous scientific and technical developments have been carried out to further improve the remote sensing for decades, particularly Polarimetric Synthetic Aperture Radar(PolSAR) technique, so classification method based on PolSAR images has getted much more attention from scholars and related department around the world. The multilook polarmetric G0-Wishart model is a more flexible model which describe homogeneous, heterogeneous and extremely heterogeneous regions in the image. Moreover, the polarmetric G0-Wishart distribution dose not include the modified Bessel function of the second kind. It is a kind of simple statistical distribution model with less parameter. To prove its feasibility, a process of classification has been tested with the full-polarized Synthetic Aperture Radar (SAR) image by the method. First, apply multilook polarimetric SAR data process and speckle filter to reduce speckle influence for classification result. Initially classify the image into sixteen classes by H/A/α decomposition. Using the ICM algorithm to classify feature based on the G0-Wshart distance. Qualitative and quantitative results show that the proposed method can classify polaimetric SAR data effectively and efficiently.

  1. Coastline detection with time series of SAR images

    Science.gov (United States)

    Ao, Dongyang; Dumitru, Octavian; Schwarz, Gottfried; Datcu, Mihai

    2017-10-01

    For maritime remote sensing, coastline detection is a vital task. With continuous coastline detection results from satellite image time series, the actual shoreline, the sea level, and environmental parameters can be observed to support coastal management and disaster warning. Established coastline detection methods are often based on SAR images and wellknown image processing approaches. These methods involve a lot of complicated data processing, which is a big challenge for remote sensing time series. Additionally, a number of SAR satellites operating with polarimetric capabilities have been launched in recent years, and many investigations of target characteristics in radar polarization have been performed. In this paper, a fast and efficient coastline detection method is proposed which comprises three steps. First, we calculate a modified correlation coefficient of two SAR images of different polarization. This coefficient differs from the traditional computation where normalization is needed. Through this modified approach, the separation between sea and land becomes more prominent. Second, we set a histogram-based threshold to distinguish between sea and land within the given image. The histogram is derived from the statistical distribution of the polarized SAR image pixel amplitudes. Third, we extract continuous coastlines using a Canny image edge detector that is rather immune to speckle noise. Finally, the individual coastlines derived from time series of .SAR images can be checked for changes.

  2. Digital SAR Mosaic and Elevation Map of the Greenland Ice Sheet

    Data.gov (United States)

    National Aeronautics and Space Administration — The Digital SAR Mosaic and Elevation Map of the Greenland Ice Sheet CD-ROM combines the most detailed synthetic aperture radar (SAR) image mosaic available with the...

  3. Digital SAR Mosaic and Elevation Map of the Greenland Ice Sheet, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — The Digital SAR Mosaic and Elevation Map of the Greenland Ice Sheet CD-ROM combines the most detailed synthetic aperture radar (SAR) image mosaic available with the...

  4. Flexible T/R Modules for Large-Aperture, Space-Based SAR, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — There is a need for electronically-steerable, space-deployable SAR antenna arrays which impose minimal weight burden on the vehicles that place them into orbit. SAR...

  5. 76 FR 27387 - Agency Information Collection Activity (Lenders Staff Appraisal Reviewer (SAR) Application) Under...

    Science.gov (United States)

    2011-05-11

    ... Staff Appraisal Reviewer (SAR). Once approved, SARs will have the authority to review real estate appraisals and to issue notices of values on behalf of VA. VA uses the information collected to perform...

  6. 76 FR 20822 - Proposed Information Collection (Servicer's Staff Appraisal Reviewer (SAR) Application) Activity...

    Science.gov (United States)

    2011-04-13

    ... Appraisal Reviewer (SAR). Servicers SAR's will have the authority to review real estate appraisals and to issue liquidation notices of value on behalf of VA. VA will also use the data collected to track the...

  7. Genetic and serological typing of European infectious haematopoietic necrosis virus (IHNV) isolates

    DEFF Research Database (Denmark)

    Johansson, Tove; Einer-Jensen, Katja; Batts, William

    2009-01-01

    Infectious haematopoietic necrosis virus (IHNV) causes the lethal disease infectious haematopoietic necrosis (IHN) in juvenile salmon and trout. The nucleocapsid (N) protein gene and partial glycoprotein (G) gene (nucleotides 457 to 1061) of the European isolates IT-217A, FR-32/87, DE-DF 13/98 11...

  8. Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains.

    Science.gov (United States)

    Yuan, Yuan; Cao, Duanfang; Zhang, Yanfang; Ma, Jun; Qi, Jianxun; Wang, Qihui; Lu, Guangwen; Wu, Ying; Yan, Jinghua; Shi, Yi; Zhang, Xinzheng; Gao, George F

    2017-04-10

    The envelope spike (S) proteins of MERS-CoV and SARS-CoV determine the virus host tropism and entry into host cells, and constitute a promising target for the development of prophylactics and therapeutics. Here, we present high-resolution structures of the trimeric MERS-CoV and SARS-CoV S proteins in its pre-fusion conformation by single particle cryo-electron microscopy. The overall structures resemble that from other coronaviruses including HKU1, MHV and NL63 reported recently, with the exception of the receptor binding domain (RBD). We captured two states of the RBD with receptor binding region either buried (lying state) or exposed (standing state), demonstrating an inherently flexible RBD readily recognized by the receptor. Further sequence conservation analysis of six human-infecting coronaviruses revealed that the fusion peptide, HR1 region and the central helix are potential targets for eliciting broadly neutralizing antibodies.

  9. Zika Virus

    Science.gov (United States)

    ... through blood transfusions. There have been outbreaks of Zika virus in the United States, Africa, Southeast Asia, the ... not travel to areas where there is a Zika virus outbreak. If you do decide to travel, first ...

  10. Zika Virus

    Science.gov (United States)

    ... which is responsible for transmitting Zika virus. Photo Courtesy of: James Gathany, Centers for Disease Control and ... National Institute of Allergy and Infectious Diseases. Photo Courtesy of NIH "You could have a Zika virus ...

  11. Chikungunya Virus

    Science.gov (United States)

    ... Gaines, PhD, MPH, MA, CHES Differentiating Chikungunya From Dengue: A Clinical Challenge For Travelers CDC Travelers' Health Chikungunya Virus Home Prevention Transmission Symptoms & Treatment Geographic Distribution Chikungunya virus in the United States ...

  12. Il monitoraggio degli spostamenti con Interferometria SAR Terrestre

    Directory of Open Access Journals (Sweden)

    Paolo Mazzanti

    2012-04-01

    Full Text Available Circa un anno fa l’autore del presente articolo è stato invitato a scrivere una nota sull’Interferometria SARTerrestre per una rivista internazionale specializzata sul monitoraggio geotecnico. A un anno di distanza ha ritenuto di interesse tradurre e aggiornare quel lavoro al fine di renderlo più facilmente fruibile alla comunità geomatica italiana.   Displacement monitoring by Terrestrial SAR Interferometry Remote sensing techniques are one of the main innovation in the field  of geotechnical and structural monitoring, since they are changing the philosophy from “contact” to “non-contact” monitoring. Over the last years Terrestrial SAR Interferometry (TInSAR has proven to be one of the most effective solutions for the fully remote and accurate monitoring of mm displacement.

  13. 3-D Target Location from Stereoscopic SAR Images

    Energy Technology Data Exchange (ETDEWEB)

    DOERRY,ARMIN W.

    1999-10-01

    SAR range-Doppler images are inherently 2-dimensional. Targets with a height offset lay over onto offset range and azimuth locations. Just which image locations are laid upon depends on the imaging geometry, including depression angle, squint angle, and target bearing. This is the well known layover phenomenon. Images formed with different aperture geometries will exhibit different layover characteristics. These differences can be exploited to ascertain target height information, in a stereoscopic manner. Depending on the imaging geometries, height accuracy can be on the order of horizontal position accuracies, thereby rivaling the best IFSAR capabilities in fine resolution SAR images. All that is required for this to work are two distinct passes with suitably different geometries from any plain old SAR.

  14. High Efficient Universal Buck Boost Solar Array Regulator SAR Module

    Science.gov (United States)

    Kimmelmann, Stefan; Knorr, Wolfgang

    2014-08-01

    The high efficient universal Buck Boost Solar Array Regulator (SAR) module concept is applicable for a wide range of input and output voltages. The single point failure tolerant SAR module contains 3 power converters for the transfer of the SAR power to the battery dominated power bus. The converters are operating parallel in a 2 out of 3 redundancy and are driven by two different controllers. The output power of one module can be adjusted up to 1KW depending on the requirements. The maximum power point tracker (MPPT) is placed on a separate small printed circuit board and can be used if no external tracker signal is delivered. Depending on the mode and load conditions an efficiency of more than 97% is achievable. The stable control performance is achieved by implementing the magnetic current sense detection. The sensed power coil current is used in Buck and Boost control mode.

  15. SAR Imagery Segmentation by Statistical Region Growing and Hierarchical Merging

    Energy Technology Data Exchange (ETDEWEB)

    Ushizima, Daniela Mayumi; Carvalho, E.A.; Medeiros, F.N.S.; Martins, C.I.O.; Marques, R.C.P.; Oliveira, I.N.S.

    2010-05-22

    This paper presents an approach to accomplish synthetic aperture radar (SAR) image segmentation, which are corrupted by speckle noise. Some ordinary segmentation techniques may require speckle filtering previously. Our approach performs radar image segmentation using the original noisy pixels as input data, eliminating preprocessing steps, an advantage over most of the current methods. The algorithm comprises a statistical region growing procedure combined with hierarchical region merging to extract regions of interest from SAR images. The region growing step over-segments the input image to enable region aggregation by employing a combination of the Kolmogorov-Smirnov (KS) test with a hierarchical stepwise optimization (HSWO) algorithm for the process coordination. We have tested and assessed the proposed technique on artificially speckled image and real SAR data containing different types of targets.

  16. UNSUPERVISED CHANGE DETECTION IN SAR IMAGES USING GAUSSIAN MIXTURE MODELS

    Directory of Open Access Journals (Sweden)

    E. Kiana

    2015-12-01

    Full Text Available In this paper, we propose a method for unsupervised change detection in Remote Sensing Synthetic Aperture Radar (SAR images. This method is based on the mixture modelling of the histogram of difference image. In this process, the difference image is classified into three classes; negative change class, positive change class and no change class. However the SAR images suffer from speckle noise, the proposed method is able to map the changes without speckle filtering. To evaluate the performance of this method, two dates of SAR data acquired by Uninhabited Aerial Vehicle Synthetic from an agriculture area are used. Change detection results show better efficiency when compared to the state-of-the-art methods.

  17. THz-SAR Vibrating Target Imaging via the Bayesian Method

    Directory of Open Access Journals (Sweden)

    Bin Deng

    2017-01-01

    Full Text Available Target vibration bears important information for target recognition, and terahertz, due to significant micro-Doppler effects, has strong advantages for remotely sensing vibrations. In this paper, the imaging characteristics of vibrating targets with THz-SAR are at first analyzed. An improved algorithm based on an excellent Bayesian approach, that is, the expansion-compression variance-component (ExCoV method, has been proposed for reconstructing scattering coefficients of vibrating targets, which provides more robust and efficient initialization and overcomes the deficiencies of sidelobes as well as artifacts arising from the traditional correlation method. A real vibration measurement experiment of idle cars was performed to validate the range model. Simulated SAR data of vibrating targets and a tank model in a real background in 220 GHz show good performance at low SNR. Rapidly evolving high-power terahertz devices will offer viable THz-SAR application at a distance of several kilometers.

  18. Il monitoraggio degli spostamenti con Interferometria SAR Terrestre

    Directory of Open Access Journals (Sweden)

    Paolo Mazzanti

    2012-04-01

    Full Text Available Circa un anno fa l’autore del presente articolo è stato invitato a scrivere una nota sull’Interferometria SARTerrestre per una rivista internazionale specializzata sul monitoraggio geotecnico. A un anno di distanza ha ritenuto di interesse tradurre e aggiornare quel lavoro al fine di renderlo più facilmente fruibile alla comunità geomatica italiana. Displacement monitoring by Terrestrial SAR InterferometryRemote sensing techniques are one of the main innovation in the field  of geotechnical and structural monitoring, since they are changing the philosophy from “contact” to “non-contact” monitoring. Over the last years Terrestrial SAR Interferometry (TInSAR has proven to be one of the most effective solutions for the fully remote and accurate monitoring of mm displacement.  

  19. Polar format algorithm for SAR imaging with Matlab

    Science.gov (United States)

    Deming, Ross; Best, Matthew; Farrell, Sean

    2014-06-01

    Due to its computational efficiency, the polar format algorithm (PFA) is considered by many to be the workhorse for airborne synthetic aperture radar (SAR) imaging. PFA is implemented in spatial Fourier space, also known as "K-space", which is a convenient domain for understanding SAR performance metrics, sampling requirements, etc. In this paper the mathematics behind PFA are explained and computed examples are presented, both using simulated data, and experimental airborne radar data from the Air Force Research Laboratory (AFRL) Gotcha Challenge collect. In addition, a simple graphical method is described that can be used to model and predict wavefront curvature artifacts in PFA imagery, which are due to the limited validity of the underlying far-field approximation. The appendix includes Matlab code for computing SAR images using PFA.

  20. Polarimetric SAR interferometry applied to land ice: modeling

    DEFF Research Database (Denmark)

    Dall, Jørgen; Papathanassiou, Konstantinos; Skriver, Henning

    2004-01-01

    depths. The validity of the scattering models is examined using L-band polarimetric interferometric SAR data acquired with the EMISAR system over an ice cap located in the percolation zone of the Greenland ice sheet. Radar reflectors were deployed on the ice surface prior to the data acquisition in order......This paper introduces a few simple scattering models intended for the application of polarimetric SAR interfer-ometry to land ice. The principal aim is to eliminate the penetration bias hampering ice sheet elevation maps generated with single-channel SAR interferometry. The polarimetric coherent...... scattering models are similar to the oriented-volume model and the random-volume-over-ground model used in vegetation studies, but the ice models are adapted to the different geometry of land ice. Also, due to compaction, land ice is not uniform; a fact that must be taken into account for large penetration...

  1. Segment-based change detection for polarimetric SAR data

    DEFF Research Database (Denmark)

    Skriver, Henning; Nielsen, Allan Aasbjerg; Conradsen, Knut

    2006-01-01

    single-channel SAR images but multi-channel algorithms have also been described. Different approaches have been used for image segmentation. Edge detection combined with region growing is one approach, where segments are created by growing regions from a previously edge detected and edge thinned image....... This method relies primarily on a robust edge detector, which preferably provides a constant false alarm rate. For single-channel SAR images this is fulfilled by the ratio edge detector, and for polarimetric SAR data, an edge detector based on the above mentioned test statistic fulfils this. Another approach......, wetlands, lakes, and urban areas. Also, other test sites over for instance urban areas have been used to assess the improvement by the segment-based change detection method. In the paper, results from pixel-based change detection, i.e. without segmentation, and from segment-based change detection, where...

  2. Physiological and molecular triggers for SARS-CoV membrane fusion and entry into host cells.

    Science.gov (United States)

    Millet, Jean Kaoru; Whittaker, Gary R

    2018-04-01

    During viral entry, enveloped viruses require the fusion of their lipid envelope with host cell membranes. For coronaviruses, this critical step is governed by the virally-encoded spike (S) protein, a class I viral fusion protein that has several unique features. Coronavirus entry is unusual in that it is often biphasic in nature, and can occur at or near the cell surface or in late endosomes. Recent advances in structural, biochemical and molecular biology of the coronavirus S protein has shed light on the intricacies of coronavirus entry, in particular the molecular triggers of coronavirus S-mediated membrane fusion. Furthermore, characterization of the coronavirus fusion peptide (FP), the segment of the fusion protein that inserts to a target lipid bilayer during membrane fusion, has revealed its particular attributes which imparts some of the unusual properties of the S protein, such as Ca 2+ -dependency. These unusual characteristics can explain at least in part the biphasic nature of coronavirus entry. In this review, using severe acute respiratory syndrome coronavirus (SARS-CoV) as model virus, we give an overview of advances in research on the coronavirus fusion peptide with an emphasis on its role and properties within the biological context of host cell entry. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Hepadna viruses

    Energy Technology Data Exchange (ETDEWEB)

    Robinson, W.; Koike, K.; Will, H.

    1987-01-01

    This book examines the molecular biology, disease pathogenesis, epidemiology, and clinical features of hepadna and other viruses with hepatic tropism and outlines future directions and approaches for their management. The volume's six sections provide a review of the various features, mechanisms, and functions of these viruses, ranging from hepadna virus replication and regulation of gene expression to the structure and function of hepadna-virus gene products.

  4. A no-calorimetric method for measuring SAR in MRI

    Science.gov (United States)

    Romano, Rocco; Acernese, Fausto; Barone, Fabrizio

    2011-04-01

    During an MR procedure, the patient absorbs a portion of the transmitted RF energy, which may result in tissue heating and other adverse effects, such as alterations in visual, auditory and neural functions. The Specific Absorption Rate (SAR), in W/kg, is the RF power absorbed per unit mass of tissue and is one of the most important parameters related with thermal effects and acts as a guideline for MRI safety. Strict limits to the SAR levels are imposed by patient safety international regulations (CEI - EN 60601 - 2 - 33) and SAR measurements are required in order to verify its respect. The recommended methods for mean SAR measurement are quite problematic and often require a maintenance man intervention and long stop machine. For example, in the CEI recommended pulse energy method, the presence of a maintenance man is required in order to correctly connect the required instrumentation; furthermore, the procedure is complex and requires remarkable processing and calculus. Simpler are the calorimetric methods, also if in this case long acquisition times are required in order to have significant temperature variations and accurate heat capacity knowledge (CEI - EN 60601 - 2 - 33). The phase transition method is a new no-calorimetric method to measure SAR in MRI which has the advantages to be very simple and to overcome all the typical calorimetric method problems. It does not require in gantry temperature measurements, any specific heat or heat capacity knowledge, but only mass and time measurement. On the other hand, it is necessary to establish if all deposited power SAR can be considered acquired and measured. In this paper, that will be shown.

  5. The phase transition method for SAR measurement in MRI

    Science.gov (United States)

    Romano, R.; Canonico, R.; Acernese, F.; Giordano, G.; Barone, F.

    2014-03-01

    During an MR procedure, the patient absorbs a portion of the transmitted RF energy, which may result in tissue heating and other adverse effects, such as alterations in visual, auditory and neural functions. The Specific Absorption Rate (SAR), in W/kg, is the RF power absorbed per unit mass of tissue and is one of the most important parameters related with thermal effects and acts as a guideline for MRI safety. Strict limits to the SAR levels are imposed by patient safety international regulations (CEI - EN 60601 - 2 - 33) and SAR measurements are required in order to verify its respect. The recommended methods for mean SAR measurement are quite problematic and often require a maintenance man intervention and long stop machine. For example, in the CEI recommended pulse energy method, the presence of a maintenance man is required in order to correctly connect the required instrumentation; furthermore, the procedure is complex and requires remarkable processing and calculus. Simpler are the calorimetric methods, also if in this case long acquisition times are required in order to have significant temperature variations and accurate heat capacity knowledge (CEI - EN 60601 - 2 - 33). The phase transition method is a new method to measure SAR in MRI which has the advantages to be very simple and to overcome all the typical calorimetric method problems. It does not require in gantry temperature measurements, any specific heat or heat capacity knowledge, but only mass and time measurement. Nevertheless, in order to consider this method it is necessary to verify that all deposited SAR power can be considered acquired and measured. In this paper considerations about this aspect are conducted.

  6. Capability of geometric features to classify ships in SAR imagery

    Science.gov (United States)

    Lang, Haitao; Wu, Siwen; Lai, Quan; Ma, Li

    2016-10-01

    Ship classification in synthetic aperture radar (SAR) imagery has become a new hotspot in remote sensing community for its valuable potential in many maritime applications. Several kinds of ship features, such as geometric features, polarimetric features, and scattering features have been widely applied on ship classification tasks. Compared with polarimetric features and scattering features, which are subject to SAR parameters (e.g., sensor type, incidence angle, polarization, etc.) and environment factors (e.g., sea state, wind, wave, current, etc.), geometric features are relatively independent of SAR and environment factors, and easy to be extracted stably from SAR imagery. In this paper, the capability of geometric features to classify ships in SAR imagery with various resolution has been investigated. Firstly, the relationship between the geometric feature extraction accuracy and the SAR imagery resolution is analyzed. It shows that the minimum bounding rectangle (MBR) of ship can be extracted exactly in terms of absolute precision by the proposed automatic ship-sea segmentation method. Next, six simple but effective geometric features are extracted to build a ship representation for the subsequent classification task. These six geometric features are composed of length (f1), width (f2), area (f3), perimeter (f4), elongatedness (f5) and compactness (f6). Among them, two basic features, length (f1) and width (f2), are directly extracted based on the MBR of ship, the other four are derived from those two basic features. The capability of the utilized geometric features to classify ships are validated on two data set with different image resolutions. The results show that the performance of ship classification solely by geometric features is close to that obtained by the state-of-the-art methods, which obtained by a combination of multiple kinds of features, including scattering features and geometric features after a complex feature selection process.

  7. Surface deformation of Taipei basin detected by Differential SAR Interferometry

    Science.gov (United States)

    Chen, Y.; Chang, C.; Yen, J.; Lin, M.

    2006-12-01

    Taiwan island is located between the southeastern periphery of the Eurasian plate and the Philippine Sea plate. The two converging plates produced very active tectonics, and can be seen by the high seismicity and deformation rate. Taipei, the highest populated area, center of politics, and economics in Taiwan, is in Taipei basin at the northern part of the island. There are several faults in and surrounding the basin, and the city is threatened with a high geological hazard potential that we should keep monitoring the crustal deformation to prevent and mitigate the disaster effect. The aims of our study is to apply the DInSAR technique to determine the surface deformation of Taipei basin area, and discussing the relation between the manifestation of deformation and the tectonically active region, Shanjiao fault. In the past few years, Differential SAR Interferometry (DInSAR) has been proved to be a powerful technique for monitoring the neotectonic activities and natural hazards. High spatial sampling rate of DInSAR technique allows studies of surface deformations with centimeter accuracy. In this area, we used ERS-1/2 SAR images acquired from 1993 to 2005 to generate 10 differential interferograms and processed the data using DIAPASON developed by CNES and SRTM global DEM.From our results, the deformation rate in Taipei is generally high in the western end of the basin along the Shanjiao fault and decrease eastward, while the subsidence center often appeared in the center of the Taipei basin. The neotectonic activity of the Shanjiao fault appeared to be insignificant by itself but it seemed to separate the subsiding basin from the surrounding areas. Further comparison between our DInSAR results and isopach of the Taipei basin revealed that the subsidence centers appeared in the interferograms did not coincide with the location where the sediments are thickest. Our results from differential interferometry will be compared to other geodetic measurements such as the

  8. Palmitoylation of the cysteine-rich endodomain of the SARS-coronavirus spike glycoprotein is important for spike-mediated cell fusion

    International Nuclear Information System (INIS)

    Petit, Chad M.; Chouljenko, Vladimir N.; Iyer, Arun; Colgrove, Robin; Farzan, Michael; Knipe, David M.; Kousoulas, K.G.

    2007-01-01

    The SARS-coronavirus (SARS-CoV) is the etiological agent of the severe acute respiratory syndrome (SARS). The SARS-CoV spike (S) glycoprotein mediates membrane fusion events during virus entry and virus-induced cell-to-cell fusion. The cytoplasmic portion of the S glycoprotein contains four cysteine-rich amino acid clusters. Individual cysteine clusters were altered via cysteine-to-alanine amino acid replacement and the modified S glycoproteins were tested for their transport to cell-surfaces and ability to cause cell fusion in transient transfection assays. Mutagenesis of the cysteine cluster I, located immediately proximal to the predicted transmembrane, domain did not appreciably reduce cell-surface expression, although S-mediated cell fusion was reduced by more than 50% in comparison to the wild-type S. Similarly, mutagenesis of the cysteine cluster II located adjacent to cluster I reduced S-mediated cell fusion by more than 60% compared to the wild-type S, while cell-surface expression was reduced by less than 20%. Mutagenesis of cysteine clusters III and IV did not appreciably affect S cell-surface expression or S-mediated cell fusion. The wild-type S was palmitoylated as evidenced by the efficient incorporation of 3 H-palmitic acid in wild-type S molecules. S glycoprotein palmitoylation was significantly reduced for mutant glycoproteins having cluster I and II cysteine changes, but was largely unaffected for cysteine cluster III and IV mutants. These results show that the S cytoplasmic domain is palmitoylated and that palmitoylation of the membrane proximal cysteine clusters I and II may be important for S-mediated cell fusion

  9. Scattering Mechanism Extraction by a Modified Cloude-Pottier Decomposition for Dual Polarization SAR

    Directory of Open Access Journals (Sweden)

    Kefeng Ji

    2015-06-01

    Full Text Available Dual polarization is a typical operational mode of polarimetric synthetic aperture radar (SAR. However, few studies have considered the scattering mechanism extraction of dual-polarization SARs. A modified Cloude-Pottier decomposition is proposed to investigate the performance of the scattering mechanism extraction of dual-polarization SARs. It is theoretically demonstrated that only HH-VV SAR can discriminate the three canonical scattering mechanisms from an isotropic surface, horizontal dipole, and isotropic dihedral. Various experiments are conducted using 21 scenes from real datasets acquired by AIRSAR, Convair-580 SAR, EMISAR, E-SAR, Pi-SAR, and RADARSAT-2. Division of the dual-polarization H-α plane is experimentally obtained. The lack of cross-polarization induces the diffusion of scattering mechanisms and their overlap in the HH-VV H-α plane. However, the performance of HH-VV SAR for extracting scattering mechanisms is acceptable. Thus, HH-VV SAR is a suitable alternative to full-polarization SAR in certain cases. Meanwhile, the extraction performance of the other two dual-polarization SARs is badly degraded due to the lack of co-polarization. Therefore, HH-HV and HV-VV SARs cannot effectively extract the scattering mechanisms in the H-α plane.

  10. Impact of Severe Acute Respiratory Syndrome (SARS Outbreaks on the Use of Emergency Department Medical Resources

    Directory of Open Access Journals (Sweden)

    Chien-Cheng Huang

    2005-06-01

    Conclusion: The SARS outbreak did not eliminate the need of critically ill patients for advanced medical support. However, besides an overall decrease in patient numbers, the SARS epidemic markedly altered demographic information, clinical characteristics, and the use of medical services by adult patients in the ED of a SARS-dedicated hospital.

  11. Integrating interferometric SAR data with levelling measurements of land subsidence using geostatistics

    NARCIS (Netherlands)

    Zhou, Y.; Stein, A.; Molenaar, M.

    2003-01-01

    Differential Synthetic Aperture Radar (SAR) interferometric (D-InSAR) data of ground surface deformation are affected by several error sources associated with image acquisitions and data processing. In this paper, we study the use of D-InSAR for quantifying land subsidence due to groundwater

  12. Single and Multipolarimetric P-Band SAR Tomography of Subsurface Ice Structure

    DEFF Research Database (Denmark)

    Banda, Francesco; Dall, Jørgen; Tebaldini, Stefano

    2016-01-01

    Agency IceSAR 2012 campaign is discussed. IceSAR 2012 was conceived so as to support the secondary objectives of the future Earth Explorer mission BIOMASS, which will be a SAR instrument with media penetration capabilities due to the use of the P-band frequency. In this regard, a tomographic study of ice...

  13. Pyrimidine and nucleoside gamma-esters of L-Glu-Sar

    DEFF Research Database (Denmark)

    Eriksson, André H; Elm, Peter L; Begtrup, Mikael

    2005-01-01

    -tetrahydrofuran-3-yl ester)-Sar (I), l-Glu(thymine-1-yl-methyl ester)-Sar (II) and l-Glu(acyclothymidine)-Sar (III) were synthesised and in vitro stability was studied in various aqueous and biological media. Affinity to and translocation via hPEPT1 was investigated in mature Caco-2 cell monolayers, grown...

  14. SAR image enhancement via post-correlation signal processing

    Science.gov (United States)

    Matthews, N. D.; Kaupp, V. H.; Waite, W. P.; Macdonald, H. C.

    1984-01-01

    Seventeen interpreters ranked sets of computer-generated radar imagery to assess the value of post-correlation processing on the interpretability of SAR (synthetic aperture radar) imagery. The post-correlation processing evaluated amounts to a nonlinear mapping of the signal exiting a digital correlator and allows full use of signal bandwidth for improving the spatial resolution or for noise reduction. The results indicate that it is reasonable to hypothesize an optimal SAR presentation format for specific applications even though this study was too limited to be specific.

  15. Crop Classification Using Short-Revisit Multitemporal SAR Data

    DEFF Research Database (Denmark)

    Skriver, Henning; Mattia, Francesco; Satalino, Giuseppe

    2011-01-01

    Classification of crops and other land cover types is an important application of both optical/infrared and SAR satellite data. It is already an import application of present satellite systems, as it will be for planned missions, such as the Sentinels. An airborne SAR data set with a short revisit......, and that cross-polarized backscatter produces the best results, with errors down to 3%–6% at the two frequencies. There is a trade-off between the polarimetric information and the multitemporal information, where the best overall results are obtained using the multitemporal information. If only a few...

  16. Marine Targets Classification in PolInSAR Data

    Science.gov (United States)

    Chen, Peng; Yang, Jingsong; Ren, Lin

    2014-11-01

    In this paper, marine stationary targets and moving targets are studied by Pol-In-SAR data of Radarsat-2. A new method of stationary targets detection is proposed. The method get the correlation coefficient image of the In-SAR data, and using the histogram of correlation coefficient image. Then, A Constant False Alarm Rate (CFAR) algorithm and The Probabilistic Neural Network model are imported to detect stationary targets. To find the moving targets, Azimuth Ambiguity is show as an important feature. We use the length of azimuth ambiguity to get the target's moving direction and speed. Make further efforts, Targets classification is studied by rebuild the surface elevation of marine targets.

  17. Airborne Multi-Band SAR in the Arctic

    Science.gov (United States)

    Gardner, J. M.; Brozena, J. M.; Liang, R.; Ball, D.; Holt, B.; Thomson, J.

    2016-12-01

    As one component of the Office of Naval Research supported Sea State Departmental Research Initiative during October of 2015 the Naval Research Laboratory flew an ultrawide-band, low-frequency, polarimetric SAR over the southward advancing sea ice in Beaufort Sea. The flights were coordinated with the research team aboard the R/V Sikuliaq working near and in the advancing pack ice. The majority of the SAR data were collected with the L-Band sensor (1000-1500 MHz) from an altitude of 10,000', providing a useful swath 6 km wide with 75o and 25 o angles of incidence at the inner and outer edge of the swath respectively. Some data were also collected with the P-Band SAR (215-915 MHz). The extremely large bandwidths allowed for formation of image pixels as small as 30 cm, however, we selected 60 cm pixel size to reduce image speckle. The separate polarimetric images are calibrated to one pixel to allow for calculations such as polarimetric decompositions that require the images to be well aligned. Both frequencies are useful particularly for the detection of ridges and areas of deformed ice. There are advantages and disadvantages to airborne SAR imagery compared to satellites. The chief advantages being the enormous allowable bandwidth leading to very fine range resolution, and the ability to fly arbitrary trajectories on demand. The latter permits specific areas to be imaged at a given time with a specified illumination direction. An area can even be illuminated from all directions by flying a circular trajectory around the target area. This captures ice features that are sensitive to illumination direction such as cracks, sastrugi orientation, and ridges. The disadvantages include variation of intensity across the swath with range and incidence angle. In addition to the SAR data, we collected photogrammetric imagery from a DSS-439, scanning lidar from a Riegl Q560 and surface brightness temperatures from a KT-19. However, since all of these sensors are nadir pointing

  18. The Danish real-time SAR processor: first results

    DEFF Research Database (Denmark)

    Dall, Jørgen; Jørgensen, Jørn Hjelm; Netterstrøm, Anders

    1993-01-01

    . The processor is capable of focusing the entire swath of the raw SAR data into full resolution, and depending on the choice made by the on-board operator, either a high resolution one-look zoom image or a spatially multilooked overview image is displayed. After a brief design review, the paper addresses various......A real-time processor (RTP) for the Danish airborne Synthetic Aperture Radar (SAR) has been designed and constructed at the Electromagnetics Institute. The implementation was completed in mid 1992, and since then the RTP has been operated successfully on several test and demonstration flights...

  19. Structure and inhibition of the SARS coronavirus envelope protein ion channel.

    Directory of Open Access Journals (Sweden)

    Konstantin Pervushin

    2009-07-01

    Full Text Available The envelope (E protein from coronaviruses is a small polypeptide that contains at least one alpha-helical transmembrane domain. Absence, or inactivation, of E protein results in attenuated viruses, due to alterations in either virion morphology or tropism. Apart from its morphogenetic properties, protein E has been reported to have membrane permeabilizing activity. Further, the drug hexamethylene amiloride (HMA, but not amiloride, inhibited in vitro ion channel activity of some synthetic coronavirus E proteins, and also viral replication. We have previously shown for the coronavirus species responsible for severe acute respiratory syndrome (SARS-CoV that the transmembrane domain of E protein (ETM forms pentameric alpha-helical bundles that are likely responsible for the observed channel activity. Herein, using solution NMR in dodecylphosphatidylcholine micelles and energy minimization, we have obtained a model of this channel which features regular alpha-helices that form a pentameric left-handed parallel bundle. The drug HMA was found to bind inside the lumen of the channel, at both the C-terminal and the N-terminal openings, and, in contrast to amiloride, induced additional chemical shifts in ETM. Full length SARS-CoV E displayed channel activity when transiently expressed in human embryonic kidney 293 (HEK-293 cells in a whole-cell patch clamp set-up. This activity was significantly reduced by hexamethylene amiloride (HMA, but not by amiloride. The channel structure presented herein provides a possible rationale for inhibition, and a platform for future structure-based drug design of this potential pharmacological target.

  20. Visualizing and interpreting surface displacement patterns on unstable slopes using multi-geometry satellite SAR interferometry (2D InSAR)

    OpenAIRE

    Eriksen, Harald Øverli; Lauknes, Tom Rune; Larsen, Yngvar; Corner, Geoffrey D.; Bergh, Steffen G; Dehls, John; Kierulf, Halfdan Pascal

    2017-01-01

    It is well known that satellite radar interferometry (InSAR) is capable of measuring surface displacement with a typical accuracy on the order of millimeters to centimeters. However, when the true deformation vector differs from the satellite line-of-sight (LOS), the sensitivity decreases and interpretation of InSAR deformationmeasurements becomes challenging. By combining displacement data fromextensive ascending and descending TerraSAR-X datasets collected during the summer seasons...

  1. SAR: A novel application for FM-CW radars

    NARCIS (Netherlands)

    Wit, J.J.M. de; Hoogeboom, P.

    2001-01-01

    For small-scale earth observation applications, there ia a special interest in low-cost, high-resolution imaging radars small, enough to be operated from small, possibly unmanned aircraft. The combination of FM-CW technology and the high resolution of SAR systems should result in such a small,

  2. The TerraSAR-X Traffic Monitoring System

    OpenAIRE

    Runge, Hartmut; Suchandt, Steffen; Palubinskas, Gintautas; Meyer, Franz; Reinartz, Peter; Müller, Rupert

    2005-01-01

    The presentation gives an overview about the TerraSAR-X traffic monitoring project at DLR. The tasks of the "traffic processor" and the overall ground segment are described. Results from first airborne campaigns are presented including the monitoring of a traffic jam on a motorway near Munich / Germany. Furthermore radar cross sections of passenger cars are presented.

  3. Offshore Wind Resource Estimation in Mediterranean Area Using SAR Images

    DEFF Research Database (Denmark)

    Calaudi, Rosamaria; Arena, Felice; Badger, Merete

    Satellite observations of the ocean surface from Synthetic Aperture Radars (SAR) provide information about the spatial wind variability over large areas. This is of special interest in the Mediterranean, where spatial wind information is only provided by sparse buoys, often with long periods...

  4. SAR Target Recognition with Feature Fusion Based on Stacked Autoencoder

    Directory of Open Access Journals (Sweden)

    Kang Miao

    2017-04-01

    Full Text Available A feature fusion algorithm based on a Stacked AutoEncoder (SAE for Synthetic Aperture Rader (SAR imagery is proposed in this paper. Firstly, 25 baseline features and Three-Patch Local Binary Patterns (TPLBP features are extracted. Then, the features are combined in series and fed into the SAE network, which is trained by a greedy layer-wise method. Finally, the softmax classifier is employed to fine tune the SAE network for better fusion performance. Additionally, the Gabor texture features of SAR images are extracted, and the fusion experiments between different features are carried out. The results show that the baseline features and TPLBP features have low redundancy and high complementarity, which makes the fused feature more discriminative. Compared with the SAR target recognition algorithm based on SAE or CNN (Convolutional Neural Network, the proposed method simplifies the network structure and increases the recognition accuracy and efficiency. 10-classes SAR targets based on an MSTAR dataset got a classification accuracy up to 95.88%, which verifies the effectiveness of the presented algorithm.

  5. Unsupervised Classification of SAR Images using Hierarchical Agglomeration and EM

    NARCIS (Netherlands)

    K. Kayabol (Koray); V. Krylov; J. Zerubia; E. Salerno; A.E. Cetin; O. Salvetti

    2012-01-01

    htmlabstractWe implement an unsupervised classification algorithm for high resolution Synthetic Aperture Radar (SAR) images. The foundation of algorithm is based on Classification Expectation-Maximization (CEM). To get rid of two drawbacks of EM type algorithms, namely the initialization and the

  6. Quartz red TL SAR equivalent dose overestimation for Chinese loess

    DEFF Research Database (Denmark)

    Lai, Z.P.; Murray, A.S.; Bailey, R.M.

    2006-01-01

    For the red TL of quartz extracted from Chinese loess, the single-aliquot regenerative-dose (SAR) procedure overestimates the known laboratory doses in dose recovery test. The overestimation is the result of the first heating during the measurement of natural TL signal causing a sensitivity...

  7. Dual Polarized Waveguide Phased Array for SAR Application

    NARCIS (Netherlands)

    Chan, K.K.; Visser, H.J.; Keizer, W.P.M.N.; Turner, R.M.

    1994-01-01

    A modal technique is employed to evaluate the suitability of a square waveguide element for use in a dual polarized phased array. The element is found to possess low active reflection coefficient and high cross-polar isolation over the bandwith and scan volume that are typically required for SAR

  8. UWB front-end for SAR-based imaging system

    NARCIS (Netherlands)

    Monni, S.; Grooters, R.; Neto, A.; Nennie, F.A.

    2010-01-01

    A planarly fed UWB leaky lens antenna is presented integrated with wide band transmit and receive front-end electronics, to be used in a SAR-based imaging system. The unique non-dispersive characteristics of this antenna over a very wide bandwidth, together with the dual band front-end electronics

  9. Subsurface ice structure analysis with longer wavelength sar tomography

    DEFF Research Database (Denmark)

    Banda, Francesco; Dall, Jørgen; Tebaldini, Stefano

    2013-01-01

    Given the extreme importance of monitoring ice sheets with remote sensing instruments in order to predict their interactions with the environment, the ESA IceSAR 2012 campaign was performed in south-west Greenland in the framework of BIOMASS activities. The objective was to assess the capability...

  10. The Utility of SAR to Monitor Ocean Processes.

    Science.gov (United States)

    1981-11-01

    radar backscatter occurs. This phenomenon has been seen on Seasat SAR imagery of North Rona Rock, Bermuda , and Isle de Gonave (Haiti). The exact cause...deployed at the ver- Waverider buoy and to examine the variability of the direc- tices and center of an equilateral triangle with 3 m sides. The tional

  11. A Collection of SAR Methodologies for Monitoring Wetlands

    Directory of Open Access Journals (Sweden)

    Lori White

    2015-06-01

    Full Text Available Wetlands are an important natural resource that requires monitoring. A key step in environmental monitoring is to map the locations and characteristics of the resource to better enable assessment of change over time. Synthetic Aperture Radar (SAR systems are helpful in this way for wetland resources because their data can be used to map and monitor changes in surface water extent, saturated soils, flooded vegetation, and changes in wetland vegetation cover. We review a few techniques to demonstrate SAR capabilities for wetland monitoring, including the commonly used method of grey-level thresholding for mapping surface water and highlighting changes in extent, and approaches for polarimetric decompositions to map flooded vegetation and changes from one class of land cover to another. We use the Curvelet-based change detection and the Wishart-Chernoff Distance approaches to show how they substantially improve mapping of flooded vegetation and flagging areas of change, respectively. We recommend that the increasing availability SAR data and the proven ability of these data to map various components of wetlands mean SAR should be considered as a critical component of a wetland monitoring system.

  12. Target detection with polarimetric C-band SAR

    NARCIS (Netherlands)

    Broek, A.C. van den; Dekker, R.J.; Smith, A.J.E.; Vries, F.P.P. de

    1999-01-01

    We have studied an optimal target detection procedure for polarimetric SAR data by using PHARUS data collected during the MIMEX campaign. The detection method is especially suitable when no a priory knowledge of the target is available. We have found that polarimetric whitening filtering preceding

  13. Mobile phone types and SAR characteristics of the human brain

    Science.gov (United States)

    Lee, Ae-Kyoung; Hong, Seon-Eui; Kwon, Jong-Hwa; Choi, Hyung-Do; Cardis, Elisabeth

    2017-04-01

    Mobile phones differ in terms of their operating frequency, outer shape, and form and location of the antennae, all of which affect the spatial distributions of their electromagnetic field and the level of electromagnetic absorption in the human head or brain. For this paper, the specific absorption rate (SAR) was calculated for four anatomical head models at different ages using 11 numerical phone models of different shapes and antenna configurations. The 11 models represent phone types accounting for around 86% of the approximately 1400 commercial phone models released into the Korean market since 2002. Seven of the phone models selected have an internal dual-band antenna, and the remaining four possess an external antenna. Each model was intended to generate an average absorption level equivalent to that of the same type of commercial phone model operating at the maximum available output power. The 1 g peak spatial SAR and ipsilateral and contralateral brain-averaged SARs were reported for all 11 phone models. The effects of the phone type, phone position, operating frequency, and age of head models on the brain SAR were comprehensively determined.

  14. LTE modem power consumption, SAR and RF signal strength emulation

    DEFF Research Database (Denmark)

    Musiige, Deogratius; Vincent, Laulagnet; Anton, François

    2012-01-01

    This paper presents a new methodology for emulating the LTE modem power consumption, emitted SAR and RF signal strength when transmitting an LTE signal. The inputs of the methodology are: modem logical/protocol commands, time advance, near-field specifier, and antenna characteristics. The power...

  15. An Advanced Rotation Invariant Descriptor for SAR Image Registration

    Directory of Open Access Journals (Sweden)

    Yuming Xiang

    2017-07-01

    Full Text Available The Scale-Invariant Feature Transform (SIFT algorithm and its many variants have been widely used in Synthetic Aperture Radar (SAR image registration. The SIFT-like algorithms maintain rotation invariance by assigning a dominant orientation for each keypoint, while the calculation of dominant orientation is not robust due to the effect of speckle noise in SAR imagery. In this paper, we propose an advanced local descriptor for SAR image registration to achieve rotation invariance without assigning a dominant orientation. Based on the improved intensity orders, we first divide a circular neighborhood into several sub-regions. Second, rotation-invariant ratio orientation histograms of each sub-region are proposed by accumulating the ratio values of different directions in a rotation-invariant coordinate system. The proposed descriptor is composed of the concatenation of the histograms of each sub-region. In order to increase the distinctiveness of the proposed descriptor, multiple image neighborhoods are aggregated. Experimental results on several satellite SAR images have shown an improvement in the matching performance over other state-of-the-art algorithms.

  16. Evaluation of Sentinel-3 SAR Performance over Arctic Sea Ice

    Science.gov (United States)

    Di Bella, A.; Simonsen, S.; Skourup, H.; Sandberg Sorensen, L.; Forsberg, R.

    2016-12-01

    Sea ice is a fundamental component of the Earth climate system since it influences directly the albedo of our planet and regulates the heat exchange between the atmosphere and the ocean. Global weather patterns and climate are therefore strictly connected to the presence and properties of sea ice which represents an important element in short- and long-term climate modelling. The launch of the EC/ESA's Sentinel-3 mission offers the opportunity to prolong the observation of sea ice topography and dynamics as well as it provides essential near real-time information for ocean and weather forecasting. In particular, the SAR radar altimeter (SRAL) carried on board of this satellite enables to estimate sea ice thickness in ice-covered areas by measuring directly the sea ice freeboard. This work evaluates Sentinel-3 SAR performance over Arctic sea ice using laser altimetry data collected during a Sentinel-3 underflight - the first with the SRAL instrument operating in SAR mode - performed as a part of the CryoVEx 2016 campaign. Snow freeboard heights derived from airborne laser scanner measurements are used to validate the sea ice freeboard obtained by processing Sentinel-3 SAR level 1b waveforms. We present the results of the freeboard comparison from a statistical point of view.

  17. Bilge dump detection from SAR imagery using local binary patterns

    CSIR Research Space (South Africa)

    Mdakane, LW

    2015-07-01

    Full Text Available 2015: Remote Sensing: Understanding the Earth for a Safer World, Milan, Italy, 26-31 July 2015 Bilge dump detection from SAR imagery using local binary patterns yz L.W. Mdakane,yz W. Kleynhans,yz C.P. Schwegmann yDepartment of Electrical...

  18. Statistical Analysis of High Resolution SAR Ground Clutter Data

    Science.gov (United States)

    2005-11-01

    forest zones. 166 Acknowledgments Thanks to Prof. Joachim Ender from FGAN for providing the AER-II data set, to Dr. Alberto Moreira from DLR...for providing the E-SAR data set, to Dr. Joao Moreira for providing the Aes-1 data set when at Aerosensing Radarsysteme, and to Dr. David Imel for

  19. Subsurface ice structure analysis with longer wavelength sar tomography

    DEFF Research Database (Denmark)

    Banda, Francesco; Dall, Jørgen; Tebaldini, Stefano

    2013-01-01

    of longer wavelength SAR to retrieve information about ice flow and structure. In the present paper first results from processing of tomographic data for subsurface ice structure mapping are presented. The extent of signal penetration has been found to be of about 20-60 m, conditional on the different...

  20. Insight to Global Change: EOS/SAR Mission

    Science.gov (United States)

    1990-01-01

    This video presentation describes the methods and instrumentation used to help in determining future climate changes on Earth and explains the benefits of experimentation with synthetic aperture radar (SAR). It also gives a better understanding of the burning of fossil fuels, deterioration of the biosphere and deforestation of the rain forest which causes the greenhouse effect.

  1. Design and Calibration of the PHARUS Polarimetric Airborne SAR

    NARCIS (Netherlands)

    Snoeij, P.; Hoogeboom, P.; Koomen, P.J.; Vermeulen, B.C.B.; Pouwels, H.

    1996-01-01

    The PHARUS system uses a phased array antenna with solid state amplifiers. The project consisted of two phases, a definition phase and a realization phase. The definition phase consisted of the actual realization of a SAR research system called PHARS, which made its first successful testflight in

  2. Mobile phone types and SAR characteristics of the human brain.

    Science.gov (United States)

    Lee, Ae-Kyoung; Hong, Seon-Eui; Kwon, Jong-Hwa; Choi, Hyung-Do; Cardis, Elisabeth

    2017-04-07

    Mobile phones differ in terms of their operating frequency, outer shape, and form and location of the antennae, all of which affect the spatial distributions of their electromagnetic field and the level of electromagnetic absorption in the human head or brain. For this paper, the specific absorption rate (SAR) was calculated for four anatomical head models at different ages using 11 numerical phone models of different shapes and antenna configurations. The 11 models represent phone types accounting for around 86% of the approximately 1400 commercial phone models released into the Korean market since 2002. Seven of the phone models selected have an internal dual-band antenna, and the remaining four possess an external antenna. Each model was intended to generate an average absorption level equivalent to that of the same type of commercial phone model operating at the maximum available output power. The 1 g peak spatial SAR and ipsilateral and contralateral brain-averaged SARs were reported for all 11 phone models. The effects of the phone type, phone position, operating frequency, and age of head models on the brain SAR were comprehensively determined.

  3. Agricultural Land Cover from Multitemporal C-Band SAR Data

    Science.gov (United States)

    Skriver, H.

    2013-12-01

    Henning Skriver DTU Space, Technical University of Denmark Ørsteds Plads, Building 348, DK-2800 Lyngby e-mail: hs@space.dtu.dk Problem description This paper focuses on land cover type from SAR data using high revisit acquisitions, including single and dual polarisation and fully polarimetric data, at C-band. The data set were acquired during an ESA-supported campaign, AgriSAR09, with the Radarsat-2 system. Ground surveys to obtain detailed land cover maps were performed during the campaign. Classification methods using single- and dual-polarisation data, and fully polarimetric data are used with multitemporal data with short revisit time. Results for airborne campaigns have previously been reported in Skriver et al. (2011) and Skriver (2012). In this paper, the short revisit satellite SAR data will be used to assess the trade-off between polarimetric SAR data and data as single or dual polarisation SAR data. This is particularly important in relation to the future GMES Sentinel-1 SAR satellites, where two satellites with a relatively wide swath will ensure a short revisit time globally. Questions dealt with are: which accuracy can we expect from a mission like the Sentinel-1, what is the improvement of using polarimetric SAR compared to single or dual polarisation SAR, and what is the optimum number of acquisitions needed. Methodology The data have sufficient number of looks for the Gaussian assumption to be valid for the backscatter coefficients for the individual polarizations. The classification method used for these data is therefore the standard Bayesian classification method for multivariate Gaussian statistics. For the full-polarimetric cases two classification methods have been applied, the standard ML Wishart classifier, and a method based on a reversible transform of the covariance matrix into backscatter intensities. The following pre-processing steps were performed on both data sets: The scattering matrix data in the form of SLC products were

  4. Immunology of Bats and Their Viruses: Challenges and Opportunities

    Science.gov (United States)

    Schountz, Tony

    2014-01-01

    Bats are reservoir hosts of several high-impact viruses that cause significant human diseases, including Nipah virus, Marburg virus and rabies virus. They also harbor many other viruses that are thought to have caused disease in humans after spillover into intermediate hosts, including SARS and MERS coronaviruses. As is usual with reservoir hosts, these viruses apparently cause little or no pathology in bats. Despite the importance of bats as reservoir hosts of zoonotic and potentially zoonotic agents, virtually nothing is known about the host/virus relationships; principally because few colonies of bats are available for experimental infections, a lack of reagents, methods and expertise for studying bat antiviral responses and immunology, and the difficulty of conducting meaningful field work. These challenges can be addressed, in part, with new technologies that are species-independent that can provide insight into the interactions of bats and viruses, which should clarify how the viruses persist in nature, and what risk factors might facilitate transmission to humans and livestock. PMID:25494448

  5. Immunology of Bats and Their Viruses: Challenges and Opportunities

    Directory of Open Access Journals (Sweden)

    Tony Schountz

    2014-12-01

    Full Text Available Bats are reservoir hosts of several high-impact viruses that cause significant human diseases, including Nipah virus, Marburg virus and rabies virus. They also harbor many other viruses that are thought to have caused disease in humans after spillover into intermediate hosts, including SARS and MERS coronaviruses. As is usual with reservoir hosts, these viruses apparently cause little or no pathology in bats. Despite the importance of bats as reservoir hosts of zoonotic and potentially zoonotic agents, virtually nothing is known about the host/virus relationships; principally because few colonies of bats are available for experimental infections, a lack of reagents, methods and expertise for studying bat antiviral responses and immunology, and the difficulty of conducting meaningful field work. These challenges can be addressed, in part, with new technologies that are species-independent that can provide insight into the interactions of bats and viruses, which should clarify how the viruses persist in nature, and what risk factors might facilitate transmission to humans and livestock.

  6. Immunology of bats and their viruses: challenges and opportunities.

    Science.gov (United States)

    Schountz, Tony

    2014-12-01

    Bats are reservoir hosts of several high-impact viruses that cause significant human diseases, including Nipah virus, Marburg virus and rabies virus. They also harbor many other viruses that are thought to have caused disease in humans after spillover into intermediate hosts, including SARS and MERS coronaviruses. As is usual with reservoir hosts, these viruses apparently cause little or no pathology in bats. Despite the importance of bats as reservoir hosts of zoonotic and potentially zoonotic agents, virtually nothing is known about the host/virus relationships; principally because few colonies of bats are available for experimental infections, a lack of reagents, methods and expertise for studying bat antiviral responses and immunology, and the difficulty of conducting meaningful field work. These challenges can be addressed, in part, with new technologies that are species-independent that can provide insight into the interactions of bats and viruses, which should clarify how the viruses persist in nature, and what risk factors might facilitate transmission to humans and livestock.

  7. Mechanisms for SAR imaging of ocean surface phenomena: Theory and experiment

    Science.gov (United States)

    Vesecky, J. F.

    1983-01-01

    Understanding the SAR response to surface wave is a central issue in the analysis of SAR ocean images. The imaging mechanism for gravity waves and the practical question of just which characteristics of the ocean wave field can be measured remotely using SAR were examined. Assessments of wave imaging theory are based primarily on comparisons of the directional wave height variance spectrum psi (K) measured by in situ buoys with estimates from SAR images. Other criteria are also recommended, e.g., the effects of focus adjustments. It is assumed that fluctuations in SAR image intensity are proportional to fluctuations in ocean surface height. If this were true, the Fourier power spectrum of a SAR image and corresponding surface measurements of psi would coincide. Differences between SAR estimates based on this hypothesis and buoy measurements of psi are then used to begin the assessment of rival wave imaging theories.

  8. A New SAR Image Segmentation Algorithm for the Detection of Target and Shadow Regions

    Science.gov (United States)

    Huang, Shiqi; Huang, Wenzhun; Zhang, Ting

    2016-01-01

    The most distinctive characteristic of synthetic aperture radar (SAR) is that it can acquire data under all weather conditions and at all times. However, its coherent imaging mechanism introduces a great deal of speckle noise into SAR images, which makes the segmentation of target and shadow regions in SAR images very difficult. This paper proposes a new SAR image segmentation method based on wavelet decomposition and a constant false alarm rate (WD-CFAR). The WD-CFAR algorithm not only is insensitive to the speckle noise in SAR images but also can segment target and shadow regions simultaneously, and it is also able to effectively segment SAR images with a low signal-to-clutter ratio (SCR). Experiments were performed to assess the performance of the new algorithm on various SAR images. The experimental results show that the proposed method is effective and feasible and possesses good characteristics for general application. PMID:27924935

  9. UTILIZING SAR AND MULTISPECTRAL INTEGRATED DATA FOR EMERGENCY RESPONSE

    Directory of Open Access Journals (Sweden)

    S. Havivi

    2016-06-01

    Full Text Available Satellite images are used widely in the risk cycle to understand the exposure, refine hazard maps and quickly provide an assessment after a natural or man-made disaster. Though there are different types of satellite images (e.g. optical, radar these have not been combined for risk assessments. The characteristics of different remote sensing data type may be extremely valuable for monitoring and evaluating the impacts of disaster events, to extract additional information thus making it available for emergency situations. To base this approach, two different change detection methods, for two different sensor's data were used: Coherence Change Detection (CCD for SAR data and Covariance Equalization (CE for multispectral imagery. The CCD provides an identification of the stability of an area, and shows where changes have occurred. CCD shows subtle changes with an accuracy of several millimetres to centimetres. The CE method overcomes the atmospheric effects differences between two multispectral images, taken at different times. Therefore, areas that had undergone a major change can be detected. To achieve our goals, we focused on the urban areas affected by the tsunami event in Sendai, Japan that occurred on March 11, 2011 which affected the surrounding area, coastline and inland. High resolution TerraSAR-X (TSX and Landsat 7 images, covering the research area, were acquired for the period before and after the event. All pre-processed and processed according to each sensor. Both results, of the optical and SAR algorithms, were combined by resampling the spatial resolution of the Multispectral data to the SAR resolution. This was applied by spatial linear interpolation. A score representing the damage level in both products was assigned. The results of both algorithms, high level of damage is shown in the areas closer to the sea and shoreline. Our approach, combining SAR and multispectral images, leads to more reliable information and provides a

  10. Novel Alphacoronaviruses and Paramyxoviruses Cocirculate with Type 1 and Severe Acute Respiratory System (SARS)-Related Betacoronaviruses in Synanthropic Bats of Luxembourg.

    Science.gov (United States)

    Pauly, Maude; Pir, Jacques B; Loesch, Catherine; Sausy, Aurélie; Snoeck, Chantal J; Hübschen, Judith M; Muller, Claude P

    2017-09-15

    Several infectious disease outbreaks with high mortality in humans have been attributed to viruses that are thought to have evolved from bat viruses. In this study from Luxembourg, the genetic diversity and epidemiology of paramyxoviruses and coronaviruses shed by the bat species Rhinolophus ferrumequinum and Myotis emarginatus were evaluated. Feces collection ( n = 624) was performed longitudinally in a mixed-species colony in 2015 and 2016. In addition, feces ( n = 254) were collected cross-sectionally from six Myotis emarginatus colonies in 2016. By use of degenerate primers in a nested format, overall prevalences of 1.1% (10/878) and 4.9% (43/878) were determined for paramyxoviruses and coronaviruses. Sequences of the partial RNA-dependent RNA polymerase and spike glycoprotein genes of coronaviruses, as well as sequences of the partial L gene of paramyxoviruses, were obtained. Novel paramyxovirus and Alphacoronavirus strains were identified in different Myotis emarginatus colonies, and severe acute respiratory syndrome (SARS)-related Betacoronavirus strains were shed by Rhinolophus ferrumequinum Logistic regression revealed that the level of Alphacoronavirus shedding was highest in July (odds ratio, 2.8; P bats also host Betacoronavirus 1 strains. The high similarity of the spike gene sequences of these viruses with mammalian Betacoronavirus 1 strains may be of concern. Both the SARS-related and Betacoronavirus 1 strains detected in bats in Luxembourg may cross the species barrier after a host adaptation process. IMPORTANCE Bats are a natural reservoir of a number of zoonotic pathogens. Several severe outbreaks in humans (e.g., a Nipah virus outbreak in Malaysia in 1998, and the almost global spread of severe acute respiratory syndrome in 2003) have been caused by bat-borne viruses that were transmitted to humans mostly after virus adaptation (e.g., in intermediate animal hosts). Despite the indigenousness of bat species that host viruses with suspected

  11. Expression and diagnostic use of recombinant M protein of the porcine reproductive and respiratory syndrome virus

    Directory of Open Access Journals (Sweden)

    Jitka Frölichová

    2017-01-01

    Full Text Available Matrix M protein combined with nucleocapsid N protein could be a promising combination of virus antigens for diagnosing the porcine reproductive and respiratory syndrome. The goal of this work was to express the recombinant M protein of the porcine reproductive and respiratory syndrome virus in Escherichia coli cells and compare its serological reactivity with the N protein of the virus. The gene coding for the M protein was cloned into the pDest17 vector. The resulting protein was purified by metalochelating affinity chromatography. Recombinant M protein was applied as an antigen in immunoblot test and compared on a panel of porcine sera with N protein based IDEXX test. Of 120 examined samples, the majority (78.3% gave identical results using both compared tests. From the group of discrepant results, IDEXX test identified considerably more positive sera (17.5% than M protein based test (4.2%. The main contribution of the work is finding that although IDEXX test proved to be more sensitive than M protein based test, 4.2% of sera would escape detection by serological test based on N protein. Further development and purification of the M protein for the use in Enzyme Linked Immunosorbent Assay format test could increase the performance of serological testing.

  12. The eukaryotic elongation factor 1A is critical for genome replication of the paramyxovirus respiratory syncytial virus.

    Directory of Open Access Journals (Sweden)

    Ting Wei

    Full Text Available The eukaryotic translation factor eEF1A assists replication of many RNA viruses by various mechanisms. Here we show that down-regulation of eEF1A restricts the expression of viral genomic RNA and the release of infectious virus, demonstrating a biological requirement for eEF1A in the respiratory syncytial virus (RSV life cycle. The key proteins in the replicase/transcriptase complex of RSV; the nucleocapsid (N protein, phosphoprotein (P and matrix (M protein, all associate with eEF1A in RSV infected cells, although N is the strongest binding partner. Using individually expressed proteins, N, but not P or M bound to eEF1A. This study demonstrates a novel interaction between eEF1A and the RSV replication complex, through binding to N protein, to facilitate genomic RNA synthesis and virus production.

  13. The eukaryotic elongation factor 1A is critical for genome replication of the paramyxovirus respiratory syncytial virus.

    Science.gov (United States)

    Wei, Ting; Li, Dongsheng; Marcial, Daneth; Khan, Moshin; Lin, Min-Hsuan; Snape, Natale; Ghildyal, Reena; Harrich, David; Spann, Kirsten

    2014-01-01

    The eukaryotic translation factor eEF1A assists replication of many RNA viruses by various mechanisms. Here we show that down-regulation of eEF1A restricts the expression of viral genomic RNA and the release of infectious virus, demonstrating a biological requirement for eEF1A in the respiratory syncytial virus (RSV) life cycle. The key proteins in the replicase/transcriptase complex of RSV; the nucleocapsid (N) protein, phosphoprotein (P) and matrix (M) protein, all associate with eEF1A in RSV infected cells, although N is the strongest binding partner. Using individually expressed proteins, N, but not P or M bound to eEF1A. This study demonstrates a novel interaction between eEF1A and the RSV replication complex, through binding to N protein, to facilitate genomic RNA synthesis and virus production.

  14. CHLORELLA VIRUSES

    Science.gov (United States)

    Yamada, Takashi; Onimatsu, Hideki; Van Etten, James L.

    2007-01-01

    Chlorella viruses or chloroviruses are large, icosahedral, plaque‐forming, double‐stranded‐DNA—containing viruses that replicate in certain strains of the unicellular green alga Chlorella. DNA sequence analysis of the 330‐kbp genome of Paramecium bursaria chlorella virus 1 (PBCV‐1), the prototype of this virus family (Phycodnaviridae), predict ∼366 protein‐encoding genes and 11 tRNA genes. The predicted gene products of ∼50% of these genes resemble proteins of known function, including many that are completely unexpected for a virus. In addition, the chlorella viruses have several features and encode many gene products that distinguish them from most viruses. These products include: (1) multiple DNA methyltransferases and DNA site‐specific endonucleases, (2) the enzymes required to glycosylate their proteins and synthesize polysaccharides such as hyaluronan and chitin, (3) a virus‐encoded K+ channel (called Kcv) located in the internal membrane of the virions, (4) a SET domain containing protein (referred to as vSET) that dimethylates Lys27 in histone 3, and (5) PBCV‐1 has three types of introns; a self‐splicing intron, a spliceosomal processed intron, and a small tRNA intron. Accumulating evidence indicates that the chlorella viruses have a very long evolutionary history. This review mainly deals with research on the virion structure, genome rearrangements, gene expression, cell wall degradation, polysaccharide synthesis, and evolution of PBCV‐1 as well as other related viruses. PMID:16877063

  15. Ebola virus and severe acute respiratory syndrome coronavirus display late cell entry kinetics: evidence that transport to NPC1+ endolysosomes is a rate-defining step.

    Science.gov (United States)

    Mingo, Rebecca M; Simmons, James A; Shoemaker, Charles J; Nelson, Elizabeth A; Schornberg, Kathryn L; D'Souza, Ryan S; Casanova, James E; White, Judith M

    2015-03-01

    Ebola virus (EBOV) causes hemorrhagic fevers with high mortality rates. During cellular entry, the virus is internalized by macropinocytosis and trafficked through endosomes until fusion between the viral and an endosomal membrane is triggered, releasing the RNA genome into the cytoplasm. We found that while macropinocytotic uptake of filamentous EBOV viruslike particles (VLPs) expressing the EBOV glycoprotein (GP) occurs relatively quickly, VLPs only begin to enter the cytoplasm after a 30-min lag, considerably later than particles bearing the influenza hemagglutinin or GP from lymphocytic choriomeningitis virus, which enter through late endosomes (LE). For EBOV, the long lag is not due to the large size or unusual shape of EBOV filaments, the need to prime EBOV GP to the 19-kDa receptor-binding species, or a need for unusually low endosomal pH. In contrast, since we observed that EBOV entry occurs upon arrival in Niemann-Pick C1 (NPC1)-positive endolysosomes (LE/Lys), we propose that trafficking to LE/Lys is a key rate-defining step. Additional experiments revealed, unexpectedly, that severe acute respiratory syndrome (SARS) S-mediated entry also begins only after a 30-min lag. Furthermore, although SARS does not require NPC1 for entry, SARS entry also begins after colocalization with NPC1. Since the only endosomal requirement for SARS entry is cathepsin L activity, we tested and provide evidence that NPC1(+) LE/Lys have higher cathepsin L activity than LE, with no detectable activity in earlier endosomes. Our findings suggest that both EBOV and SARS traffic deep into the endocytic pathway for entry and that they do so to access higher cathepsin activity. Ebola virus is a hemorrhagic fever virus that causes high fatality rates when it spreads from zoonotic vectors into the human population. Infection by severe acute respiratory syndrome coronavirus (SARS-CoV) causes severe respiratory distress in infected patients. A devastating outbreak of EBOV occurred in West

  16. The Medicinal Chemistry of Dengue Virus.

    Science.gov (United States)

    Behnam, Mira A M; Nitsche, Christoph; Boldescu, Veaceslav; Klein, Christian D

    2016-06-23

    The dengue virus and related flaviviruses are an increasing global health threat. In this perspective, we comment on and review medicinal chemistry efforts aimed at the prevention or treatment of dengue infections. We include target-based approaches aimed at viral or host factors and results from phenotypic screenings in cellular assay systems for viral replication. This perspective is limited to the discussion of results that provide explicit chemistry or structure-activity relationship (SAR), or appear to be of particular interest to the medicinal chemist for other reasons. The discovery and development efforts discussed here may at least partially be extrapolated toward other emerging flaviviral infections, such as West Nile virus. Therefore, this perspective, although not aimed at flaviviruses in general, should also be able to provide an overview of the medicinal chemistry of these closely related infectious agents.

  17. The use of fluorescence microscopy to visualise homotypic interactions of tomato spotted wilt virus nucleocapsid protein in living cells

    NARCIS (Netherlands)

    Snippe, M.; Borst, J.W.; Goldbach, R.W.; Kormelink, R.J.M.

    2005-01-01

    Fluorescence resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM) were employed to study homotypic protein¿protein interactions in living cells. To this end, the nucleocapsid (N) protein of tomato spotted wilt virus (TSWV) was expressed as a fusion protein with either

  18. Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine

    International Nuclear Information System (INIS)

    He Yuxian; Zhou Yusen; Liu Shuwen; Kou Zhihua; Li Wenhui; Farzan, Michael; Jiang Shibo

    2004-01-01

    The spike (S) protein of severe acute respiratory syndrome (SARS) coronavirus (CoV), a type I transmembrane envelope glycoprotein, consists of S1 and S2 domains responsible for virus binding and fusion, respectively. The S1 contains a receptor-binding domain (RBD) that can specifically bind to angiotensin-converting enzyme 2 (ACE2), the receptor on target cells. Here we show that a recombinant fusion protein (designated RBD-Fc) containing 193-amino acid RBD (residues 318-510) and a human IgG1 Fc fragment can induce highly potent antibody responses in the immunized rabbits. The antibodies recognized RBD on S1 domain and completely inhibited SARS-CoV infection at a serum dilution of 1:10,240. Rabbit antisera effectively blocked binding of S1, which contains RBD, to ACE2. This suggests that RBD can induce highly potent neutralizing antibody responses and has potential to be developed as an effective and safe subunit vaccine for prevention of SARS

  19. Severe acute respiratory syndrome (SARS): chest radiographic features in children

    Energy Technology Data Exchange (ETDEWEB)

    Babyn, Paul S.; Gahunia, Harpal K.; Manson, David [Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario (Canada); Chu, Winnie C.W.; Metreweli, Constantine [Prince of Wales Hospital, Shatin (China); Department of Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong (China); Tsou, Ian Y.Y.; Wansaicheong, Gervais K.L.; Chee, Thomas S.G.; Kaw, Gregory J.L. [Department of Diagnostic Radiology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng (Singapore); Allen, Upton; Bitnun, Ari; Read, Stanley [Division of Infectious Diseases, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario (Canada); Cheng, Frankie W.T.; Fok, Tai-Fai; Hon, Ellis K.L.; Li, Albert M.; Ng, Pak-Cheung [Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, Hong Kong, SAR (China); Chiu, Man-Chun; Leung, Chi-Wai [Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Lai King Hill Road, Lai Chi Kok, Hong Kong, SAR (China); Khong, Pek L. [Department of Diagnostic Radiology, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, SAR (China); Stringer, David A.

    2004-01-01

    We abstracted data (n=62) on the radiologic appearance and course of SARS in pediatric patients with suspect (n=25) or probable (n=37) SARS, diagnosed in five hospital sites located in three cities: Toronto, Singapore, and Hong Kong. Available chest radiographs and thoracic CTs were reviewed for the presence of the following radiographic findings: airspace disease, air bronchograms, airways inflammation and peribronchial thickening, interstitial disease, pleural effusion, and hilar adenopathy. A total of 62 patients (suspect=25, probable=37) were evaluated for SARS. Patient ages ranged from 5.5 months to 17 years and 11.5 months (average, 6 years and 10 months) with a female-to-male ratio of 32:30. Forty-one patients (66.1%) were in close contact with other probable, suspect, or quarantined cases; 10 patients (16.1%) had recently traveled to WHO-designated affected areas within 10 days; and 7 patients (11.2%) were transferred from other hospitals that had SARS patients. Three patients, who did not have close/hospital contact or travel history to affected areas, were classified as SARS cases based on their clinical signs and symptoms and on the fact that they were living in an endemic area. The most prominent clinical presentations were fever, with a temperature over 38 C (100%), cough (62.9%), rhinorrhea (22.6%), myalgia (17.7%), chills (14.5%), and headache (11.3%). Other findings included sore throat (9.7%), gastrointestinal symptoms (9.7%), rigor (8.1%), and lethargy (6.5%). In general, fever and cough were the most common clinical presentations amongst younger pediatric SARS cases (age<10 years), whereas, in addition to these symptoms, headache, myalgia, sore throat, chills, and/or rigor were common in older patients (age{>=}10 years). The chest radiographs of 35.5% of patients were normal. The most prominent radiological findings that were observed in the remaining patients were areas of consolidation (45.2%), often peripheral with multifocal lesions in 22

  20. Rapid Flood Map Generation from Spaceborne SAR Observations

    Science.gov (United States)

    Yun, S. H.; Liang, C.; Manipon, G.; Jung, J.; Gurrola, E. M.; Owen, S. E.; Hua, H.; Agram, P. S.; Webb, F.; Sacco, G. F.; Rosen, P. A.; Simons, M.

    2016-12-01

    The Advanced Rapid Imaging and Analysis (ARIA) team has responded to the January 2016 US Midwest Floods along the Mississippi River. Daily teleconferences with FEMA, NOAA, NGA, and USGS, provided information on precipitation and flood crest migration, based on which we coordinated with the Japanese Aerospace Exploration Agency (JAXA) through NASA headquarters for JAXA's ALOS-2 timely tasking over two paths. We produced flood extent maps using ALOS-2 SM3 mode Level 1.5 data that were provided through the International Charter and stored at the US Geological Survey's Hazards Data Distribution System (HDDS) archive. On January 6, the first four frames (70 km x 240 km) were acquired, which included the City of Memphis. We registered post-event SAR images to pre-event images, applied radiometric calibration, took a logarithm of the ratio of the two images. Two thresholds were applied to represent flooded areas that became open water (colored in blue) and flooded areas with tall vegetation (colored in red). The second path was acquired on January 11 further down along the Mississippi River. Seven frames (70 km x 420 km) were acquired and flood maps were created in the similar fashion. The maps were delivered to the FEMA as well as posted on ARIA's public website. The FEMA stated that SAR provides inspection priority for optical imagery and ground response. The ALOS-2 data and the products have been a very important source of information during this response as the flood crest has moved down stream. The SAR data continue to be an important resource during times when optical observations are often not useful. In close collaboration with FEMA and USGS, we also work on other flood events including June 2016 China Floods using European Space Agency's (ESA's) Sentienl-1 data, to produce flood extent maps and identify algorithmic needs and ARIA system's requirements to automate and rapidly produce and deliver flood maps for future events. With the addition of Sentinel-1B

  1. Severe acute respiratory syndrome (SARS): chest radiographic features in children

    International Nuclear Information System (INIS)

    Babyn, Paul S.; Gahunia, Harpal K.; Manson, David; Chu, Winnie C.W.; Metreweli, Constantine; Tsou, Ian Y.Y.; Wansaicheong, Gervais K.L.; Chee, Thomas S.G.; Kaw, Gregory J.L.; Allen, Upton; Bitnun, Ari; Read, Stanley; Cheng, Frankie W.T.; Fok, Tai-Fai; Hon, Ellis K.L.; Li, Albert M.; Ng, Pak-Cheung; Chiu, Man-Chun; Leung, Chi-Wai; Khong, Pek L.; Stringer, David A.

    2004-01-01

    We abstracted data (n=62) on the radiologic appearance and course of SARS in pediatric patients with suspect (n=25) or probable (n=37) SARS, diagnosed in five hospital sites located in three cities: Toronto, Singapore, and Hong Kong. Available chest radiographs and thoracic CTs were reviewed for the presence of the following radiographic findings: airspace disease, air bronchograms, airways inflammation and peribronchial thickening, interstitial disease, pleural effusion, and hilar adenopathy. A total of 62 patients (suspect=25, probable=37) were evaluated for SARS. Patient ages ranged from 5.5 months to 17 years and 11.5 months (average, 6 years and 10 months) with a female-to-male ratio of 32:30. Forty-one patients (66.1%) were in close contact with other probable, suspect, or quarantined cases; 10 patients (16.1%) had recently traveled to WHO-designated affected areas within 10 days; and 7 patients (11.2%) were transferred from other hospitals that had SARS patients. Three patients, who did not have close/hospital contact or travel history to affected areas, were classified as SARS cases based on their clinical signs and symptoms and on the fact that they were living in an endemic area. The most prominent clinical presentations were fever, with a temperature over 38 C (100%), cough (62.9%), rhinorrhea (22.6%), myalgia (17.7%), chills (14.5%), and headache (11.3%). Other findings included sore throat (9.7%), gastrointestinal symptoms (9.7%), rigor (8.1%), and lethargy (6.5%). In general, fever and cough were the most common clinical presentations amongst younger pediatric SARS cases (age<10 years), whereas, in addition to these symptoms, headache, myalgia, sore throat, chills, and/or rigor were common in older patients (age≥10 years). The chest radiographs of 35.5% of patients were normal. The most prominent radiological findings that were observed in the remaining patients were areas of consolidation (45.2%), often peripheral with multifocal lesions in 22

  2. [Bats and Viruses: complex relationships].

    Science.gov (United States)

    Rodhain, F

    2015-10-01

    With more than 1 200 species, bats and flying foxes (Order Chiroptera) constitute the most important and diverse order of Mammals after Rodents. Many species of bats are insectivorous while others are frugivorous and few of them are hematophagous. Some of these animals fly during the night, others are crepuscular or diurnal. Some fly long distances during seasonal migrations. Many species are colonial cave-dwelling, living in a rather small home range while others are relatively solitary. However, in spite of the importance of bats for terrestrial biotic communities and ecosystem ecology, the diversity in their biology and lifestyles remain poorly known and underappreciated. More than sixty viruses have been detected or isolated in bats; these animals are therefore involved in the natural cycles of many of them. This is the case, for instance, of rabies virus and other Lyssavirus (Family Rhabdoviridae), Nipah and Hendra viruses (Paramyxoviridae), Ebola and Marburg viruses (Filoviridae), SARS-CoV and MERS-CoV (Coronaviridae). For these zoonotic viruses, a number of bat species are considered as important reservoir hosts, efficient disseminators or even directly responsible of the transmission. Some of these bat-borne viruses cause highly pathogenic diseases while others are of potential significance for humans and domestic or wild animals; so, bats are an important risk in human and animal public health. Moreover, some groups of viruses developed through different phylogenetic mechanisms of coevolution between viruses and bats. The fact that most of these viral infections are asymptomatic in bats has been observed since a long time but the mechanisms of the viral persistence are not clearly understood. The various bioecology of the different bat populations allows exchange of virus between migrating and non-migrating conspecific species. For a better understanding of the role of bats in the circulation of these viral zoonoses, epidemiologists must pay attention to

  3. Sar1 localizes at the rims of COPII-coated membranes in vivo.

    Science.gov (United States)

    Kurokawa, Kazuo; Suda, Yasuyuki; Nakano, Akihiko

    2016-09-01

    The Sar1 GTPase controls coat assembly on coat protein complex II (COPII)-coated vesicles, which mediate protein transport from the endoplasmic reticulum (ER) to the Golgi. The GTP-bound form of Sar1, activated by the ER-localized guanine nucleotide exchange factor (GEF) Sec12, associates with the ER membrane. GTP hydrolysis by Sar1, stimulated by the COPII-vesicle-localized GTPase-activating protein (GAP) Sec23, in turn causes Sar1 to dissociate from the membrane. Thus, Sar1 is cycled between active and inactive states, and on and off vesicle membranes, but its precise spatiotemporal regulation remains unknown. Here, we examined Sar1 localization on COPII-coated membranes in living Saccharomyces cerevisiae cells. Two-dimensional (2D) observation demonstrated that Sar1 showed modest accumulation around the ER exit sites (ERES) in a manner that was dependent on Sec16 function. Detailed three-dimensional (3D) observation further demonstrated that Sar1 localized at the rims of the COPII-coated membranes, but was excluded from the rest of the COPII membranes. Additionally, a GTP-locked form of Sar1 induced abnormally enlarged COPII-coated structures and covered the entirety of these structures. These results suggested that the reversible membrane association of Sar1 GTPase leads to its localization being restricted to the rims of COPII-coated membranes in vivo. © 2016. Published by The Company of Biologists Ltd.

  4. Modified Multilook Cross Correlation technique for Doppler centroid estimation in SAR image signal processing

    Science.gov (United States)

    Bee Cheng, Sew

    Synthetic Aperture Radar (SAR) is one of the widely used remote sensing sensors which produces high resolution image by using advance signal processing technique. SAR managed to operate in all sorts of weather and cover wide range of area. To produce a high-quality image, accurate parameters such as Doppler centroid are required for precise SAR signal processing. In the azimuth matched filtering of SAR signal processing, Doppler centroid is an important azimuth parameter that helps to focus the image pixels. Doppler centroid has always been overlooked during SAR signal processing. It is due to the fact that estimation of Doppler centroid involved complicated calculation and increased computational load. Therefore, researcher used to apply only the approximate Doppler value which is not precise and cause defocus effort in the generated SAR image. In this study, several conventional Doppler centroid estimation algorithms are reviewed and developed using Matlab software program to extract the Doppler parameter from received SAR data, namely Spectrum Fit Algorithm, Wavelength Diversity Algorithm (WDA), Multilook Cross Correlation Algorithm (MLCC), and Multilook Beat Frequency Algorithm (MLBF). Two sets of SAR data are employed to evaluate the performance of each estimator, i.e. simulated point target data and RADARSAT-1 Vancouver scene raw data. These experiments gave a sense of accuracy for the estimated results together with computational time consumption. Point target is simulated to generate ideal case SAR data with pre-defined SAR system parameters.

  5. Air pollution and case fatality of SARS in the People's Republic of China: an ecologic study

    Directory of Open Access Journals (Sweden)

    Yu Shun-Zhang

    2003-11-01

    Full Text Available Abstract Background Severe acute respiratory syndrome (SARS has claimed 349 lives with 5,327 probable cases reported in mainland China since November 2002. SARS case fatality has varied across geographical areas, which might be partially explained by air pollution level. Methods Publicly accessible data on SARS morbidity and mortality were utilized in the data analysis. Air pollution was evaluated by air pollution index (API derived from the concentrations of particulate matter, sulfur dioxide, nitrogen dioxide, carbon monoxide and ground-level ozone. Ecologic analysis was conducted to explore the association and correlation between air pollution and SARS case fatality via model fitting. Partially ecologic studies were performed to assess the effects of long-term and short-term exposures on the risk of dying from SARS. Results Ecologic analysis conducted among 5 regions with 100 or more SARS cases showed that case fatality rate increased with the increment of API (case fatality = - 0.063 + 0.001 * API. Partially ecologic study based on short-term exposure demonstrated that SARS patients from regions with moderate APIs had an 84% increased risk of dying from SARS compared to those from regions with low APIs (RR = 1.84, 95% CI: 1.41–2.40. Similarly, SARS patients from regions with high APIs were twice as likely to die from SARS compared to those from regions with low APIs. (RR = 2.18, 95% CI: 1.31–3.65. Partially ecologic analysis based on long-term exposure to ambient air pollution showed the similar association. Conclusion Our studies demonstrated a positive association between air pollution and SARS case fatality in Chinese population by utilizing publicly accessible data on SARS statistics and air pollution indices. Although ecologic fallacy and uncontrolled confounding effect might have biased the results, the possibility of a detrimental effect of air pollution on the prognosis of SARS patients deserves further investigation.

  6. CHANDIPURA VIRUS

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. CHANDIPURA VIRUS. First isolated from a village called Chandipura near Nagpur in 1965 in India. Belongs to rhabdoviridae family. Used as a Model System to study RNA virus multiplication in the infected cell at molecular level. Notes:

  7. Schmallenberg Virus

    Indian Academy of Sciences (India)

    IAS Admin

    challenged with emerging and re-emerging infections that pose a constant threat to human and animal health. Indeed, researchers around the globe are still fighting deadly diseases like malaria, trypanosomosis and AIDS. In this article, we focus on a recently identified virus, namely, Schmallenberg virus as an example of a.

  8. Phytophthora viruses.

    Science.gov (United States)

    Cai, Guohong; Hillman, Bradley I

    2013-01-01

    Phytophthora sp. is a genus in the oomycetes, which are similar to filamentous fungi in morphology and habitat, but phylogenetically more closely related to brown algae and diatoms and fall in the kingdom Stramenopila. In the past few years, several viruses have been characterized in Phytophthora species, including four viruses from Phytophthora infestans, the late blight pathogen, and an endornavirus from an unnamed Phytophthora species from Douglas fir. Studies on Phytophthora viruses have revealed several interesting systems. Phytophthora infestans RNA virus 1 (PiRV-1) and PiRV-2 are likely the first members of two new virus families; studies on PiRV-3 support the establishment of a new virus genus that is not affiliated with established virus families; PiRV-4 is a member of Narnaviridae, most likely in the genus Narnavirus; and Phytophthora endornavirus 1 (PEV1) was the first nonplant endornavirus at the time of reporting. Viral capsids have not been found in any of the above-mentioned viruses. PiRV-1 demonstrated a unique genome organization that requires further examination, and PiRV-2 may have played a role in late blight resurgence in 1980s-1990s. Copyright © 2013 Elsevier Inc. All rights reserved.

  9. Seasat SAR identification of dry climate urban land cover

    Science.gov (United States)

    Henderson, F. M.; Wharton, S. W.

    1980-01-01

    Digitally processed Seasat synthetic aperture radar (SAR) imagery of the Denver, Colorado area was examined to assess its potential for mapping urban land cover and the compatibility of SAR derived classes with those described in the U.S. Geological Survey classification system. The entire scene was interpreted to generate a small-scale land cover map. In addition, six subscene enlargements representative of urban land cover categories extant in the area were used as test sites for detailed analysis of land cover types. Two distinct approaches were employed and compared in examining the imagery - a visual interpretation of black-and-white positive transparencies and an automated-machine/visual interpretation. The latter used the Image 100 interactive image analysis system to generate land cover classes by density level slicing of the image frequency histogram.

  10. Initial assessment of an airborne Ku-band polarimetric SAR.

    Energy Technology Data Exchange (ETDEWEB)

    Raynal, Ann Marie; Doerry, Armin Walter

    2013-02-01

    Polarimetric synthetic aperture radar (SAR) has been used for a variety of dual-use research applications since the 1940s. By measuring the direction of the electric field vector from radar echoes, polarimetry may enhance an analysts understanding of scattering effects for both earth monitoring and tactical surveillance missions. Polarimetry may provide insight into surface types, materials, or orientations for natural and man-made targets. Polarimetric measurements may also be used to enhance the contrast between scattering surfaces such as man-made objects and their surroundings. This report represents an initial assessment of the utility of, and applications for, polarimetric SAR at Ku-band for airborne or unmanned aerial systems.

  11. Channel Phase Error Compensation for MIMO-SAR

    Directory of Open Access Journals (Sweden)

    Lei Zhang

    2014-01-01

    Full Text Available Multi-input multioutput (MIMO is a novel technique to achieve high-resolution as well as wide swath in synthetic aperture radar (SAR systems. Channel imbalance is inevitable in multichannel systems that it declines the imaging quality. Generally, the imbalance cannot be fully compensated by simple internal calibration in a MIMO-SAR system. In this paper, a new algorithm based on raw data is presented to remove the channel phase error. Based on the error source, this approach models the phase error as two parts: the transmit phase error and the receive phase error. The receive phase error is removed using cost function at the azimuth processing stage, whereas the transmit phase error is estimated with correlation. Point target simulations confirm the influence of channel phase error and the validation of the proposed approach. Besides, the performance is also investigated.

  12. The Danish SAR system - Design and initial tests

    Science.gov (United States)

    Madsen, Soren N.; Christensen, Erik L.; Skou, Niels; Dall, Jorgen

    1991-01-01

    In January 1986, the design of a high-resolution airborne C-band SAR started at the Electromagnetics Institute of the Technical University of Denmark. The initial system test flights took place in November and December 1989. The authors describe the design of the system, its implementation, and its performance. They show how digital technology has been utilized to realize a very flexible radar with variable resolution, swath-width, and imaging geometry. The motion-compensation algorithms implemented to obtain the high resolution and the special features built into the system to ensure proper internal calibration are outlined. The data processing system, developed for image generation and quality assurance, is sketched, with special emphasis on the flexibility of the system. Sample images and a preliminary performance evaluation are presented, demonstrating that the design goals have been met. The ongoing system upgrades and the planned scientific utilization of the C-band SAR are described.

  13. Estimating soil moisture using the Danish polarimetric SAR

    DEFF Research Database (Denmark)

    Jiankang, Ji; Thomsen, A.; Skriver, Henning

    1995-01-01

    The results of applying data from the Danish polarimetric SAR (EMISAR) to estimate soil moisture for bare fields are presented. Fully calibrated C-band SAR images for hh, vv and cross polarizations have been used in this study. The measured surface roughness data showed that classical roughness...... autocorrelation functions (Gaussian and Exponential) were not able to fit natural surfaces well. A Gauss-Exp hybrid model which agreed better with the measured data has been proposed. Theoretical surface scattering models (POM, IEM), as well as an empirical model for retrieval of soil moisture and surface rms...... height from coand cross-polarized ratio, have been examined, but the results are less satisfactory. As soil moisture response to backscattering coefficient σo is mainly coupled to surface roughness effect for bare fields, a bilinear model coupling volumetric soil moisture mv and surface rms height σ...

  14. PIXEL: Japanese InSAR community for crustal deformation research

    Science.gov (United States)

    Furuya, M.; Shimada, M.; Ozawa, T.; Fukushima, Y.; Aoki, Y.; Miyagi, Y.; Kitagawa, S.

    2007-12-01

    In anticipation of the launch of ALOS (Advanced Land Observation Satellite) by JAXA (Japan Aerospace eXploration Agency), and in order to expand and bolster the InSAR community for crustal deformation research in Japan, a couple of scientists established a consortium, PIXEL, in November 2005 in a completely bottom-up fashion. PIXEL stands for Palsar Interferometry Consortium to Study our Evolving Land. Formally, it is a research contract between JAXA and Earthquake Research Institute (ERI), University of Tokyo. As ERI is a shared institute of the Japanese universities and research institutes, every scientist at all Japanese universities and institutes can participate in this consortium. The activity of PIXEL includes information exchange by mailing list, tutorial workshop for InSAR software, research workshop, and PALSAR data sharing. After the launch of ALOS, we have already witnessed several earthquakes and volcanic activities using PALSAR interferometry. We will briefly show and digest some of those observation results.

  15. Feature Fusion Based on Convolutional Neural Network for SAR ATR

    Directory of Open Access Journals (Sweden)

    Chen Shi-Qi

    2017-01-01

    Full Text Available Recent breakthroughs in algorithms related to deep convolutional neural networks (DCNN have stimulated the development of various of signal processing approaches, where the specific application of Automatic Target Recognition (ATR using Synthetic Aperture Radar (SAR data has spurred widely attention. Inspired by the more efficient distributed training such as inception architecture and residual network, a new feature fusion structure which jointly exploits all the merits of each version is proposed to reduce the data dimensions and the complexity of computation. The detailed procedure presented in this paper consists of the fused features, which make the representation of SAR images more distinguishable after the extraction of a set of features from DCNN, followed by a trainable classifier. In particular, the obtained results on the 10-class benchmark data set demonstrate that the presented architecture can achieve remarkable classification performance to the current state-of-the-art methods.

  16. Rapid subsidence over oil fields measured by SAR

    Science.gov (United States)

    Fielding, E. J.; Blom, R. G.; Goldstein, R. M.

    1998-01-01

    The Lost Hills and Belridge oil felds are in the San Joaquin Valley, California. The major oil reservoir is high porosity and low permeability diatomite. Extraction of large volumes from shallow depths causes reduction in pore pressure and subsequent compaction, forming a surface subsidence bowl. We measure this subsidence from space using interferometric analysis of SAR (Synthetic Aperture Radar) data collected by the European Space Agency Remote Sensing Satellites (ERS-1 and ERS-2). Maximum subsidence rates are as high as 40 mm in 35 days or > 400 mm/yr, measured from interferograms with time separations ranging from one day to 26 months. The 8- and 26-month interferograms contain areas where the subsidence gradient exceeds the measurement possible with ERS SAR, but shows increased detail in areas of less rapid subsidence. Synoptic mapping of subsidence distribution from satellite data powerfully complements ground-based techniques, permits measurements where access is difficult, and aids identification of underlying causes.

  17. EMISAR: A Dual-frequency, Polarimetric Airborne SAR

    DEFF Research Database (Denmark)

    Dall, Jørgen; Christensen, Erik Lintz

    2002-01-01

    . The SAR is operated at high altitudes on a Gulfstream G-3 jet aircraft. The system is very well calibrated and has low sidelobes and low cross-polar contamination. Digital technology has been utilized to realize a flexible and highly stable radar with variable resolution, swath width, and imaging geometry....... Thermal control and several calibration loops have been built into the system to ensure system stability and absolute calibration. Accurately measured antenna gains and radiation patterns are included in the calibration. The processing system is developed to support data calibration, which is the key......EMISAR is a fully polarimetric, dual frequency (L- and C-band) SAR system designed for remote sensing applications. The data are usually processed to 2×2 m resolution. The system has the capability of C-band cross-track single-pass interferometry and fully polarimetric repeat-pass interferometry...

  18. The synchronization method for distributed small satellite SAR

    Science.gov (United States)

    Xing, Lei; Gong, Xiaochun; Qiu, Wenxun; Sun, Zhaowei

    2007-11-01

    One of critical requirement for distributed small satellite SAR is the trigger time precision when all satellites turning on radar loads. This trigger operation is controlled by a dedicated communication tool or GPS system. In this paper a hardware platform is proposed which has integrated navigation, attitude control, and data handling system together. Based on it, a probabilistic synchronization method is proposed for SAR time precision requirement with ring architecture. To simplify design of transceiver, half-duplex communication way is used in this method. Research shows that time precision is relevant to relative frequency drift rate, satellite number, retry times, read error and round delay length. Installed with crystal oscillator short-term stability 10 -11 magnitude, this platform can achieve and maintain nanosecond order time error with a typical three satellites formation experiment during whole operating process.

  19. Parametric estimation of time varying baselines in airborne interferometric SAR

    DEFF Research Database (Denmark)

    Mohr, Johan Jacob; Madsen, Søren Nørvang

    1996-01-01

    A method for estimation of time varying spatial baselines in airborne interferometric synthetic aperture radar (SAR) is described. The range and azimuth distortions between two images acquired with a non-linear baseline are derived. A parametric model of the baseline is then, in a least square...... sense, estimated from image shifts obtained by cross correlation of numerous small patches throughout the image. The method has been applied to airborne EMISAR imagery from the 1995 campaign over the Storstrommen Glacier in North East Greenland conducted by the Danish Center for Remote Sensing. This has...... reduced the baseline uncertainties from several meters to the centimeter level in a 36 km scene. Though developed for airborne SAR the method can easily be adopted to satellite data...

  20. THE MOLECULAR EVOLUTION OF THE MOST DANGEROUS EMERGING VIRUS INFECTIONS

    Directory of Open Access Journals (Sweden)

    Popov NN

    2016-03-01

    Full Text Available In this paper we reviewed what is known about the emerging viruses, the hosts that they originate in, and the molecular events that drive their emergence. When a pathogen crosses over from animals to humans, or an existing human disease suddenly increases in incidence, the infectious disease is said to be ‘emerging’. Most of the emerging pathogens originate from nonhuman animal species which has been termed natural reservoirs. The number of emerging infectious diseases has increased over the last few decades, driven by both anthropogenic and environmental factors such as population growth, urbanization, global travel and trade, intensification of livestock production. Now it has been believed that the emergence process may include four steps. On the first step the exposure of the humans to a novel virus occures. On the second step the subset of the viruses overcome the cross-species barrier. Host shifts have resulted in multiple human pandemics, such as HIV from chimps the H1N1, ‘‘spanish flu’’ from birds, SARS-CoV and virus Ebola from bats. Then some viruses enables to transmit from one human to another. And on the last step the viruses that are sufficiently transmissible between humans cause outbreaks and become endemic in human populations without the requirement of a natural reservoir. This review aims to discuss the molecular mechanisms that govern virus cross-species transmission and following stage, using the emergence of HIV, SARS-CoV, virus Ebola and influenza virus A as the models.Populations of many viruses harbour abundant genetic variability due to a combination of high mutation, recombination or reassortation rates and large population sizes. Mutations and recombinations has been associated with the increases in virulence, the evasion of host immunity and the evolution of resistance to antivirals. Genetic alterations in one species may results in the acquisition of variations that allow them to overcome cross species

  1. Separated Component-Based Restoration of Speckled SAR Images

    Science.gov (United States)

    2013-01-01

    TYPE New Reprint 17. LIMITATION OF ABSTRACT UU 15. NUMBER OF PAGES 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 5c. PROGRAM ELEMENT...radar. I. INTRODUCTION COHERENT imaging systems such as synthetic aper -ture radar (SAR), holography, ultrasound, and synthetic aperture sonar suffer...noise variance by a factor of L. However, this often results in the reduction of the spatial resolution. Other types of speckle reduction methods are

  2. Performance Prediction and Verification for Bistatic SAR Synchronization Link

    OpenAIRE

    Younis, Marwan; Metzig, Robert; Krieger, Gerhard; Klein, Rainer

    2006-01-01

    Bistatic SAR systems have a high potential for scientific, commercial and security applications. One of the benefits is the possibility to generate highly accurate digital elevation models using bistatic interferometry. Examples for proposed bi- and multi-static satellite missions with interferometric capabilities are TanDEM-X and Cartwheel. Both are based on radar instruments placed on different spacecrafts, which gives rise to several technical challenges for the system realization. A f...

  3. Separated Component-Based Restoration of Speckled SAR Images

    Science.gov (United States)

    2014-01-01

    systems such as SAR, holography , ultra- sound, and synthetic aperture sonar suffer from a multiplicative noise known as speckle [1]. Speckle appears when...Award from the Office of Technology Commercialization, and an Outstanding GEMSTONE Mentor Award from the Honors College. He received the Outstanding...and Technology (University of London), London, England, in 1980 and 1984, respectively. From October 1984 to December 1984 he worked for IBM (UK) as a

  4. Reflectors for SAR performance testing-second edition

    Energy Technology Data Exchange (ETDEWEB)

    Doerry, Armin Walter

    2014-02-01

    Synthetic Aperture Radar (SAR) performance testing and estimation is facilitated by observing the system response to known target scene elements. Trihedral corner reflectors and other canonical targets play an important role because their Radar Cross Section (RCS) can be calculated analytically. However, reflector orientation and the proximity of the ground and mounting structures can significantly impact the accuracy and precision with which measurements can be made. These issues are examined in this report.

  5. Basic to Advanced InSAR Processing: GMTSAR

    Science.gov (United States)

    Sandwell, D. T.; Xu, X.; Baker, S.; Hogrelius, A.; Mellors, R. J.; Tong, X.; Wei, M.; Wessel, P.

    2017-12-01

    Monitoring crustal deformation using InSAR is becoming a standard technique for the science and application communities. Optimal use of the new data streams from Sentinel-1 and NISAR will require open software tools as well as education on the strengths and limitations of the InSAR methods. Over the past decade we have developed freely available, open-source software for processing InSAR data. The software relies on the Generic Mapping Tools (GMT) for the back-end data analysis and display and is thus called GMTSAR. With startup funding from NSF, we accelerated the development of GMTSAR to include more satellite data sources and provide better integration and distribution with GMT. In addition, with support from UNAVCO we have offered 6 GMTSAR short courses to educate mostly novice InSAR users. Currently, the software is used by hundreds of scientists and engineers around the world to study deformation at more than 4300 different sites. The most challenging aspect of the recent software development was the transition from image alignment using the cross-correlation method to a completely new alignment algorithm that uses only the precise orbital information to geometrically align images to an accuracy of better than 7 cm. This development was needed to process a new data type that is being acquired by the Sentinel-1A/B satellites. This combination of software and open data is transforming radar interferometry from a research tool into a fully operational time series analysis tool. Over the next 5 years we are planning to continue to broaden the user base through: improved software delivery methods; code hardening; better integration with data archives; support for high level products being developed for NISAR; and continued education and outreach.

  6. Magnetic moment test report for the model SAR 8108 battery

    Science.gov (United States)

    Ludwig, G. O.; Delbosco, E.; Montes, A.

    1988-05-01

    The procedures are described for determining the magnetic moment of the Eagle-Picher Model SAR 8108 Battery. The results of a test performed with this battery is presented. The experimental method used was to map the flux density field around the battery. The value of the magnetic moment was evaluated from the experimental data by a numerical procedure based on a spherical harmonic analysis and was found to be 0.050 + or - 0.005 A sq m.

  7. Efficient sliding spotlight SAR raw signal simulation of extended scenes

    Directory of Open Access Journals (Sweden)

    Huang Pingping

    2011-01-01

    Full Text Available Abstract Sliding spotlight mode is a novel synthetic aperture radar (SAR imaging scheme with an achieved azimuth resolution better than stripmap mode and ground coverage larger than spotlight configuration. However, its raw signal simulation of extended scenes may not be efficiently implemented in the two-dimensional (2D Fourier transformed domain. This article presents a novel sliding spotlight raw signal simulation approach from the wide-beam SAR imaging modes. This approach can generate sliding spotlight raw signal not only from raw data evaluated by the simulators, but also from real data in the stripmap/spotlight mode. In order to obtain the desired raw data from conventional stripmap/spotlight mode, the azimuth time-varying filtering, which is implemented by de-rotation and low-pass filtering, is adopted. As raw signal of extended scenes in the stripmap/spotlight mode can efficiently be evaluated in the 2D Fourier domain, the proposed approach provides an efficient sliding spotlight SAR simulator of extended scenes. Simulation results validate this efficient simulator.

  8. LAND COVER MAPPING USING SENTINEL-1 SAR DATA

    Directory of Open Access Journals (Sweden)

    S. Abdikan

    2016-06-01

    Full Text Available In this paper, the potential of using free-of-charge Sentinel-1 Synthetic Aperture Radar (SAR imagery for land cover mapping in urban areas is investigated. To this aim, we use dual-pol (VV+VH Interferometric Wide swath mode (IW data collected on September 16th 2015 along descending orbit over Istanbul megacity, Turkey. Data have been calibrated, terrain corrected, and filtered by a 5x5 kernel using gamma map approach. During terrain correction by using a 25m resolution SRTM DEM, SAR data has been resampled resulting into a pixel spacing of 20m. Support Vector Machines (SVM method has been implemented as a supervised pixel based image classification to classify the dataset. During the classification, different scenarios have been applied to find out the performance of Sentinel-1 data. The training and test data have been collected from high resolution image of Google Earth. Different combinations of VV and VH polarizations have been analysed and the resulting classified images have been assessed using overall classification accuracy and Kappa coefficient. Results demonstrate that, combining opportunely dual polarization data, the overall accuracy increases up to 93.28% against 73.85% and 70.74% of using individual polarization VV and VH, respectively. Our preliminary analysis points out that dual polarimetric Sentinel-1SAR data can be effectively exploited for producing accurate land cover maps, with relevant advantages for urban planning and management of large cities.

  9. SAR moving object imaging using sparsity imposing priors

    Science.gov (United States)

    Önhon, N. Özben; Çetin, Müjdat

    2017-12-01

    Synthetic aperture radar (SAR) returns from a scene with motion can be viewed as data from a stationary scene, but with phase errors due to motion. Based on this perspective, we formulate the problem of SAR imaging of motion-containing scenes as one of joint imaging and phase error compensation. The proposed method is based on the minimization of a cost function which involves sparsity-imposing regularization terms on the reflectivity field to be imaged, considering that it admits a sparse representation as well as on the spatial structure of the motion-related phase errors, reflecting the assumption that only a small percentage of the entire scene contains moving objects. To incorporate the spatial structure of the phase errors into the problem, we provide three different sparsity-enforcing prior terms. In order to achieve computational gains, we also present a two-step version of our approach, which first determines regions of interest that are likely to contain the moving objects and then applies our sparsity-driven approach for joint image reconstruction and autofocusing in such a spatially constrained setting. Our preliminary experiments demonstrate the effectiveness of this new moving target SAR imaging approach.

  10. Ocean Wave Parameters Retrieval from Sentinel-1 SAR Imagery

    Directory of Open Access Journals (Sweden)

    Weizeng Shao

    2016-08-01

    Full Text Available In this paper, a semi-empirical algorithm for significant wave height (Hs and mean wave period (Tmw retrieval from C-band VV-polarization Sentinel-1 synthetic aperture radar (SAR imagery is presented. We develop a semi-empirical function for Hs retrieval, which describes the relation between Hs and cutoff wavelength, radar incidence angle, and wave propagation direction relative to radar look direction. Additionally, Tmw can be also calculated through Hs and cutoff wavelength by using another empirical function. We collected 106 C-band stripmap mode Sentinel-1 SAR images in VV-polarization and wave measurements from in situ buoys. There are a total of 150 matchup points. We used 93 matchups to tune the coefficients of the semi-empirical algorithm and the rest 57 matchups for validation. The comparison shows a 0.69 m root mean square error (RMSE of Hs with a 18.6% of scatter index (SI and 1.98 s RMSE of Tmw with a 24.8% of SI. Results indicate that the algorithm is suitable for wave parameters retrieval from Sentinel-1 SAR data.

  11. Sample Extraction Bsaed on Helix Scattering for Polarimetric SAR Calibratio

    Science.gov (United States)

    Chang, Y.; Yang, J.; Li, P.; Zhao, L.; Shi, L.

    2017-09-01

    Polarimetric calibration (PolCAL) of Synthetic Aperture Radar (SAR) images is a significant preprocessing for further applications. Since the reflection symmetry property of distributed objects can provide stable constraints for PolCAL. It is reasonable to extract these reference samples before calibration. The helix scattering generally appears in complex urban area and disappears for a natural scatterer, making it a good measure to extract distributed objects. In this paper, a novel technique that extracts reflecting symmetry samples is proposed by using helix scattering. The helix scattering information is calculated by Yamaguchi four-component decomposition algorithm. An adaptive threshold selection algorithm based on generalized Gaussian distribution is also utilized to scale the helix scattering components automatically, getting rid of the problem of various numerical range. The extracting results will be taken as PolCAL reference samples and the Quegan method are utilized to calibrate these PolSAR images. A C-band airborne PolSAR data was taken as examples to evaluate its ability in improving calibration precision. Traditional method i.e. extracting samples with span power was also evaluated as contrast experiment. The results showed that the samples extracting method based on helix scattering can improve the Polcal precision preferably.

  12. 4G antennas for wireless eyewear devices and related SAR

    Science.gov (United States)

    Cihangir, Aykut; Whittow, Will; Panagamuwa, Chinthana; Jacquemod, Gilles; Gianesello, Frédéric; Luxey, Cyril

    2015-11-01

    In this paper, we first present a feasibility study to design 4G antennas (700-960 MHz and 1.7-2.7 GHz) for eyewear devices. Those eyewear devices should be connected to the last generation cellular networks, Wireless Local Area Networks or wireless hotspots. Three coupling element type antennas with their matching networks are evaluated in terms of reflection coefficient and total radiation efficiency when the eyewear is placed on the user's head. We also present Specific Absorption Rate (SAR) simulations when the eyewear is positioned over a homogeneous SAM phantom and over a heterogeneous VH (Visible Human) phantom: the SAR levels are compared to international limit values. In a second step, we present experimental results obtained with 3D printed eyewear and coupling elements etched on a classical PCB substrate where the matching circuits are optimized close to the feeding point of the coupling element. Simulated and measured values are in very good agreement: 7 to 16% and 9 to 35% total efficiency are respectively obtained for the low- and high-frequency bands. However, simulated SAR values are somewhat higher than authorized levels with preoccupant high electromagnetic field distribution close to the eye of the user.

  13. Multifrequency OFDM SAR in Presence of Deception Jamming

    Directory of Open Access Journals (Sweden)

    Schuerger Jonathan

    2010-01-01

    Full Text Available Orthogonal frequency division multiplexing (OFDM is considered in this paper from the perspective of usage in imaging radar scenarios with deception jamming. OFDM radar signals are inherently multifrequency waveforms, composed of a number of subbands which are orthogonal to each other. While being employed extensively in communications, OFDM has not found comparatively wide use in radar, and, particularly, in synthetic aperture radar (SAR applications. In this paper, we aim to show the advantages of OFDM-coded radar signals with random subband composition when used in deception jamming scenarios. Two approaches to create a radar signal by the jammer are considered: instantaneous frequency (IF estimator and digital-RF-memory- (DRFM- based reproducer. In both cases, the jammer aims to create a copy of a valid target image via resending the radar signal at prescribed time intervals. Jammer signals are derived and used in SAR simulations with three types of signal models: OFDM, linear frequency modulated (LFM, and frequency-hopped (FH. Presented results include simulated peak side lobe (PSL and peak cross-correlation values for random OFDM signals, as well as simulated SAR imagery with IF and DRFM jammers'-induced false targets.

  14. SAR wind retrieval: from Singlecore to Multicore and GPU computing

    Science.gov (United States)

    Myasoedov, Alexander; Monzikova, Anna

    The large spatial coverage and high resolution of spaceborne synthetic aperture radars (SAR) offers a unique opportunity to derive mesoscale wind fields over the ocean surface, providing high resolution wind fields near the shore. On the other hand, due to the large size of SAR images their processing might be a headache when dealing with operational tasks or doing long-period statistical analysis. Algorithms for satellite image processing often offer many possibilities for parallelism (e.g., pixel-by-pixel processing) which makes them good candidates for execution on high-performance parallel computing hardware such as Multicore CPUs and modern graphic processing units (GPUs). In this study we implement different SAR wind speed retrieval algorithms (e.g. CMOD4, CMOD5) for Singlecore and Multicore systems, including GPUs. For this purpose both serial and parallelized versions of CMOD algorithms were written in Matlab, Python, CPython and PyOpenCL. We apply these algorithms to an Envisat ASAR image, compare the results received with different versions of the algorithms executed on both Intel CPU and a Tesla GPU. As a result of our experiments we not only show the up to 400 times speedup of GPU comparing to CPU but also try to give some advises on how much time we have spent and efforts were made for writing the same algorithm using different programming languages. We hope that our experience will help other scientist to achieve all the goodness from the GPU/Multicore computing.

  15. Object Georeferencing in UAV-Based SAR Terrain Images

    Directory of Open Access Journals (Sweden)

    Łabowski Michał

    2016-12-01

    Full Text Available Synthetic aperture radars (SAR allow to obtain high resolution terrain images comparable with the resolution of optical methods. Radar imaging is independent on the weather conditions and the daylight. The process of analysis of the SAR images consists primarily of identifying of interesting objects. The ability to determine their geographical coordinates can increase usability of the solution from a user point of view. The paper presents a georeferencing method of the radar terrain images. The presented images were obtained from the SAR system installed on board an Unmanned Aerial Vehicle (UAV. The system was developed within a project under acronym WATSAR realized by the Military University of Technology and WB Electronics S.A. The source of the navigation data was an INS/GNSS system integrated by the Kalman filter with a feed-backward correction loop. The paper presents the terrain images obtained during flight tests and results of selected objects georeferencing with an assessment of the accuracy of the method.

  16. Snowpack permittivity profile retrieval from tomographic SAR data

    Science.gov (United States)

    Rekioua, Badreddine; Davy, Matthieu; Ferro-Famil, Laurent; Tebaldini, Stefano

    2017-01-01

    This work deals with 3D structure characterization and permittivity profile retrieval of snowpacks by tomographic SAR data processing. The acquisition system is a very high resolution ground based SAR system, developed and operated by the SAPHIR team, of IETR, University of Rennes-1 (France). It consists mainly of a vector network analyser and a multi-static antenna system, moving along two orthogonal directions, so as to obtain a two-dimensional synthetic array. Data were acquired during the AlpSAR campaign carried by the European Space Agency and led by ENVEO. In this study, tomographic imaging is performed using Time Domain Back Projection and consists in coherently combining the different recorded backscatter contributions. The assumption of free-space propagation during the focusing process is discussed and illustrated by focusing experimental data. An iterative method for estimating true refractive indices of the snow layers is presented. The antenna pattern is also compensated for. The obtained tomograms after refractive index correction are compared to the stratigraphy of the observed snowpack.

  17. An integrated hyperspectral and SAR satellite constellation for environment monitoring

    Science.gov (United States)

    Wang, Jinnian; Ren, Fuhu; Xie, Chou; An, Jun; Tong, Zhanbo

    2017-09-01

    A fully-integrated, Hyperspectral optical and SAR (Synthetic Aperture Radar) constellation of small earth observation satellites will be deployed over multiple launches from last December to next five years. The Constellation is expected to comprise a minimum of 16 satellites (8 SAR and 8 optical ) flying in two orbital planes, with each plane consisting of four satellite pairs, equally-spaced around the orbit plane. Each pair of satellites will consist of a hyperspectral/mutispectral optical satellite and a high-resolution SAR satellite (X-band) flying in tandem. The constellation is expected to offer a number of innovative capabilities for environment monitoring. As a pre-launch experiment, two hyperspectral earth observation minisatellites, Spark 01 and 02 were launched as secondary payloads together with Tansat in December 2016 on a CZ-2D rocket. The satellites feature a wide-range hyperspectral imager. The ground resolution is 50 m, covering spectral range from visible to near infrared (420 nm - 1000 nm) and a swath width of 100km. The imager has an average spectral resolution of 5 nm with 148 channels, and a single satellite could obtain hyperspectral imagery with 2.5 million km2 per day, for global coverage every 16 days. This paper describes the potential applications of constellation image in environment monitoring.

  18. MRI investigation on steroid induced osteo-ischemia of SARS

    International Nuclear Information System (INIS)

    Wang Wu; Zhang Xuezhe; Lu Yan; Li Zirong; Lin Peng; Huang Zhenguo; Hong Wen; Ren An; Shang Yanning

    2004-01-01

    Objective: To investigate the steroid induced osteo-ischemia of recovered SARS with MRI. Methods: 38 studies of MRI were performed on hips, lower limbs, shoulders, and lumbar vertebrae in 23 SARS patients treated with steroid. Hip X-ray was conducted in 7 of the 23 cases. Results: MRI: (1) Avascular osteonecrosis was found in 31 places, including 28 femoral heads (stage I 16, stage II 8, stage III 4 ), 1 tibial plateau, and 2 humerus capita; (2) Osteo-infarction was detected in multiple sites (bilateral femora, tibiae, calcaneus, and tali) in a severe case (also had osteonecrosis of bilateral femoral heads and left humerus capita). (3) Bone marrow edema was seen in 48 places, including 43 hips, 3 tibial plateaus, and 2 humerus capita. (4) Joint fluid was found in 16 hips and 9 knees. No positive finding was detected in X-ray. Conclusion: The steroid induced osteo-ischemia is frequent in SARS. The image follow-up is needed

  19. Human factors engineering checklists for application in the SAR process

    International Nuclear Information System (INIS)

    Overlin, T.K.; Romero, H.A.; Ryan, T.G.

    1995-03-01

    This technical report was produced to assist the preparers and reviewers of the human factors portions of the SAR in completing their assigned tasks regarding analysis and/or review of completed analyses. The checklists, which are the main body of the report, and the subsequent tables, were developed to assist analysts in generating the needed analysis data to complete the human engineering analysis for the SAR. The technical report provides a series of 19 human factors engineering (HFE) checklists which support the safety analyses of the US Department of Energy's (DOE) reactor and nonreactor facilities and activities. The results generated using these checklists and in the preparation of the concluding analyses provide the technical basis for preparing the human factors chapter, and subsequent inputs to other chapters, required by DOE as a part of the safety analysis reports (SARs). This document is divided into four main sections. The first part explains the origin of the checklists, the sources utilized, and other information pertaining to the purpose and scope of the report. The second part, subdivided into 19 sections, is the checklists themselves. The third section is the glossary which defines terms that could either be unfamiliar or have specific meanings within the context of these checklists. The final section is the subject index in which the glossary terms are referenced back to the specific checklist and page the term is encountered

  20. SAMPLE EXTRACTION BSAED ON HELIX SCATTERING FOR POLARIMETRIC SAR CALIBRATIO

    Directory of Open Access Journals (Sweden)

    Y. Chang

    2017-09-01

    Full Text Available Polarimetric calibration (PolCAL of Synthetic Aperture Radar (SAR images is a significant preprocessing for further applications. Since the reflection symmetry property of distributed objects can provide stable constraints for PolCAL. It is reasonable to extract these reference samples before calibration. The helix scattering generally appears in complex urban area and disappears for a natural scatterer, making it a good measure to extract distributed objects. In this paper, a novel technique that extracts reflecting symmetry samples is proposed by using helix scattering. The helix scattering information is calculated by Yamaguchi four-component decomposition algorithm. An adaptive threshold selection algorithm based on generalized Gaussian distribution is also utilized to scale the helix scattering components automatically, getting rid of the problem of various numerical range. The extracting results will be taken as PolCAL reference samples and the Quegan method are utilized to calibrate these PolSAR images. A C-band airborne PolSAR data was taken as examples to evaluate its ability in improving calibration precision. Traditional method i.e. extracting samples with span power was also evaluated as contrast experiment. The results showed that the samples extracting method based on helix scattering can improve the Polcal precision preferably.

  1. SAR11 marine bacteria require exogenous reduced sulphur for growth.

    Science.gov (United States)

    Tripp, H James; Kitner, Joshua B; Schwalbach, Michael S; Dacey, John W H; Wilhelm, Larry J; Giovannoni, Stephen J

    2008-04-10

    Sulphur is a universally required cell nutrient found in two amino acids and other small organic molecules. All aerobic marine bacteria are known to use assimilatory sulphate reduction to supply sulphur for biosynthesis, although many can assimilate sulphur from organic compounds that contain reduced sulphur atoms. An analysis of three complete 'Candidatus Pelagibacter ubique' genomes, and public ocean metagenomic data sets, suggested that members of the ubiquitous and abundant SAR11 alphaproteobacterial clade are deficient in assimilatory sulphate reduction genes. Here we show that SAR11 requires exogenous sources of reduced sulphur, such as methionine or 3-dimethylsulphoniopropionate (DMSP) for growth. Titrations of the algal osmolyte DMSP in seawater medium containing all other macronutrients in excess showed that 1.5 x 10(8) SAR11 cells are produced per nanomole of DMSP. Although it has been shown that other marine alphaproteobacteria use sulphur from DMSP in preference to sulphate, our results indicate that 'Cand. P. ubique' relies exclusively on reduced sulphur compounds that originate from other plankton.

  2. Imaging manifestations of the cavitation in pulmonary parenchyma of SARS

    International Nuclear Information System (INIS)

    Yuan Chunwang; Zhao Dawei; Wang Wei; Jia Cuiyu; Bai Chunsheng

    2004-01-01

    Objective: To investigate the imaging appearances of cavitation in pulmonary parenchyma and the clinical features of the cases of SARS. Methods: Chest imaging films and clinical data of 180 patients with clinically confirmed SARS were analyzed retrospectively. The imaging manifestations of cavitation and the clinical features of the patients were observed and evaluated. Results: Of 180 patients, cavitations were showed in 5 (2.8%), which were all found through X-ray or CT scanning. Most of them were round or irregular, and had thick wall. The 5 patients all had been in hospital and treated with more dosage antibiotics, antivirus medicines and glucocorticoid for long time, the glucocorticoid was used for 25-65 d, and in the first 10-15 days the dosage was 160-240 mg per day. In hospitalization, one of them had been diagnosed diabetes mellitus, four had increased fasting blood sugar, the counts of white blood cells [(14.1-20.4) x 10 9 /L] increased significantly, the percent of neutrophils might increased also. Meanwhile, there was a continue increase of lactate dehydrogenase (228.00-475.00 U/L), glutamic dehydrogenase (10.08-60.00 U/L) and hydroxybutyrate dehydrogenase (190.00-444.00 U/L) in lab examination. Conclusion: SARS can cause cavitation in pulmonary parenchyma in posterior process of the disease. CT scanning can find the cavitation earlier and accurately, catching the imaging features of them is helpful in differential diagnosis, guiding therapy and estimating prognosis

  3. Human factors engineering checklists for application in the SAR process

    Energy Technology Data Exchange (ETDEWEB)

    Overlin, T.K.; Romero, H.A.; Ryan, T.G.

    1995-03-01

    This technical report was produced to assist the preparers and reviewers of the human factors portions of the SAR in completing their assigned tasks regarding analysis and/or review of completed analyses. The checklists, which are the main body of the report, and the subsequent tables, were developed to assist analysts in generating the needed analysis data to complete the human engineering analysis for the SAR. The technical report provides a series of 19 human factors engineering (HFE) checklists which support the safety analyses of the US Department of Energy`s (DOE) reactor and nonreactor facilities and activities. The results generated using these checklists and in the preparation of the concluding analyses provide the technical basis for preparing the human factors chapter, and subsequent inputs to other chapters, required by DOE as a part of the safety analysis reports (SARs). This document is divided into four main sections. The first part explains the origin of the checklists, the sources utilized, and other information pertaining to the purpose and scope of the report. The second part, subdivided into 19 sections, is the checklists themselves. The third section is the glossary which defines terms that could either be unfamiliar or have specific meanings within the context of these checklists. The final section is the subject index in which the glossary terms are referenced back to the specific checklist and page the term is encountered.

  4. Surface properties of SAR11 bacteria facilitate grazing avoidance.

    Science.gov (United States)

    Dadon-Pilosof, Ayelet; Conley, Keats R; Jacobi, Yuval; Haber, Markus; Lombard, Fabien; Sutherland, Kelly R; Steindler, Laura; Tikochinski, Yaron; Richter, Michael; Glöckner, Frank Oliver; Suzuki, Marcelino T; West, Nyree J; Genin, Amatzia; Yahel, Gitai

    2017-12-01

    Oceanic ecosystems are dominated by minute microorganisms that play a major role in food webs and biogeochemical cycles 1 . Many microorganisms thrive in the dilute environment due to their capacity to locate, attach to, and use patches of nutrients and organic matter 2,3 . We propose that some free-living planktonic bacteria have traded their ability to stick to nutrient-rich organic particles for a non-stick cell surface that helps them evade predation by mucous filter feeders. We used a combination of in situ sampling techniques and next-generation sequencing to study the biological filtration of microorganisms at the phylotype level. Our data indicate that some marine bacteria, most notably the highly abundant Pelagibacter ubique and most other members of the SAR 11 clade of the Alphaproteobacteria, can evade filtration by slipping through the mucous nets of both pelagic and benthic tunicates. While 0.3 µm polystyrene beads and other similarly-sized bacteria were efficiently filtered, SAR11 members were not captured. Reversed-phase chromatography revealed that most SAR11 bacteria have a much less hydrophobic cell surface than that of other planktonic bacteria. Our data call for a reconsideration of the role of surface properties in biological filtration and predator-prey interactions in aquatic systems.

  5. A surface plasmon resonance biosensor for direct detection of the rabies virus

    Directory of Open Access Journals (Sweden)

    Jing Xu

    2012-01-01

    Full Text Available A surface plasmon resonance biosensor chip was constructed for detection of rabies virus. For the construction of the biosensor chip, N protein specific antibody and N protein specific antibody combined with G protein specific antibody of rabies virus were linked on two different flow cells on one CM5 chip, respectively. The chip was tested for the detection of rabies virus antigens using the crude extract of rabies virus from infected BHK cell strain culture. Tenfold serial dilutions of SRV9 strain virus-infected cell cultures were tested by the biosensor chip to establish the detection limit. The limit detection was approximately 70 pg/ml of nucleoprotein and glycoprotein. The biosensor chip developed in this study was employed for the detection of rabies virus in five suspect infectious specimens of brain tissue from guinea pigs; the results were compared by fluorescent antibody test. Surface plasmon resonance biosensor chip could be a useful automatic tool for prompt detection of rabies virus infection.

  6. SARS CTL vaccine candidates; HLA supertype-, genome-wide scanning and biochemical validation

    DEFF Research Database (Denmark)

    Sylvester-Hvid, C.; Nielsen, Morten; Lamberth, K.

    2004-01-01

    An effective Severe Acute Respiratory Syndrome (SARS) vaccine is likely to include components that can induce specific cytotoxic T-lymphocyte (CTL) responses. The specificities of such responses are governed by human leukocyte antigen (HLA)-restricted presentation of SARS-derived peptide epitopes...... of the HLA supertypes and identified almost 100 potential vaccine candidates. These should be further validated in SARS survivors and used for vaccine formulation. We suggest that immunobioinformatics may become a fast and valuable tool in rational vaccine design....

  7. Draft Genome Sequence of Uncultured SAR324 Bacterium lautmerah10, Binned from a Red Sea Metagenome

    KAUST Repository

    Haroon, Mohamed

    2016-02-11

    A draft genome of SAR324 bacterium lautmerah10 was assembled from a metagenome of a surface water sample from the Red Sea, Saudi Arabia. The genome is more complete and has a higher G+C content than that of previously sequenced SAR324 representatives. Its genomic information shows a versatile metabolism that confers an advantage to SAR324, which is reflected in its distribution throughout different depths of the marine water column.

  8. Airborne Downward Looking Sparse Linear Array 3-D SAR Heterogeneous Parallel Simulation

    OpenAIRE

    Yirong Wu; Weixian Tan; Xueming Peng; Wen Hong; Yanping Wang

    2013-01-01

    The airborne downward looking sparse linear array three dimensional synthetic aperture radar (DLSLA 3-D SAR) operates nadir observation with the along-track synthetic aperture formulated by platform movement and the cross-track synthetic aperture formulated by physical sparse linear array. Considering the lack of DLSLA 3-D SAR data in the current preliminary study stage, it is very important and essential to develop DLSLA 3-D SAR simulation (echo generation simulation and image reconstruction...

  9. Multi-Pixel Simultaneous Classification of PolSAR Image Using Convolutional Neural Networks

    OpenAIRE

    Lei Wang; Xin Xu; Hao Dong; Rong Gui; Fangling Pu

    2018-01-01

    Convolutional neural networks (CNN) have achieved great success in the optical image processing field. Because of the excellent performance of CNN, more and more methods based on CNN are applied to polarimetric synthetic aperture radar (PolSAR) image classification. Most CNN-based PolSAR image classification methods can only classify one pixel each time. Because all the pixels of a PolSAR image are classified independently, the inherent interrelation of different land covers is ignored. We us...

  10. Critical epitopes in the nucleocapsid protein of SFTS virus recognized by a panel of SFTS patients derived human monoclonal antibodies.

    Directory of Open Access Journals (Sweden)

    Li Yu

    Full Text Available BACKGROUND: SFTS virus (SFTSV is a newly discovered pathogen to cause severe fever with thrombocytopenia syndrome (SFTS in human. Successful control of SFTSV epidemic requires better understanding of the antigen target in humoral immune responses to the new bunyavirus infection. METHODOLOGY/PRINCIPAL FINDINGS: We have generated a combinatorial Fab antibody phage library from two SFTS patients recovered from SFTSV infection. To date, 94 unique human antibodies have been generated and characterized from over 1200 Fab antibody clones obtained by screening the library with SFTS purified virions. All those monoclonal antibodies (MAbs recognized the nucleocapsid (N protein of SFTSV while none of them were reactive to the viral glycoproteins Gn or Gc. Furthermore, over screening 1000 mouse monoclonal antibody clones derived from SFTSV virions immunization, 462 clones reacted with N protein, while only 16 clones were reactive to glycoprotein. Furthermore, epitope mapping of SFTSV N protein was performed through molecular simulation, site mutation and competitive ELISA, and we found that at least 4 distinct antigenic epitopes within N protein were recognized by those human and mouse MAbs, in particular mutation of Glu10 to Ala10 abolished or significantly reduced the binding activity of nearly most SFTS patients derived MAbs. CONCLUSIONS/SIGNIFICANCE: The large number of human recombinant MAbs derived from SFTS patients recognized the viral N protein indicated the important role of the N protein in humoral responses to SFTSV infection, and the critical epitopes we defined in this study provided molecular basis for detection and diagnosis of SFTSV infection.

  11. Advanced L-Band SAR System Concepts for High-Resolution Ultra-Wide-Swath SAR Imaging

    OpenAIRE

    Krieger, Gerhard; Queiroz de Almeida, Felipe; Huber, Sigurd; Villano, Michelangelo; Younis, Marwan; Moreira, Alberto; del Castillo, Javier; Rodriguez-Cassola, Marc; Prats, Pau; Petrolati, Daniele; Ludwig, Michael; Buck, C.; Suess, Martin; Gebert, Nicolas

    2017-01-01

    This paper reviews multichannel SAR instrument architectures, modes and processing techniques for the imaging of ultra-wide swaths with high azimuth resolution. The review includes both direct radiating arrays and reflector-based system architectures that are operated in either a single-transmit multiple-receive (SIMO) or in a multiple-transmit multiple-receive (MIMO) mode. The work has been conducted by DLR under the ESA contract -Advanced Processing Techniques for Next Generation Multichann...

  12. A strategy for Local Surface Stability Monitoring Using SAR Imagery

    Science.gov (United States)

    Kim, J.; Lan, C. W.; Lin, S. Y.; vanGasselt, S.; Yun, H.

    2017-12-01

    In order to provide sufficient facilities to satisfy a growing number of residents, nowadays there are many constructions and maintenance of infrastructures or buildings undergoing above and below the surface of urban area. In some cases we have learned that disasters might happen if the developments were conducted on unknown or geologically unstable ground or in over-developed areas. To avoid damages caused by such settings, it is essential to perform a regular monitoring scheme to understand the ground stability over the whole urban area. Through long-term monitoring, we firstly aim to observe surface stability over the construction sites. Secondly, we propose to implement an automatic extraction and tracking of suspicious unstable area. To achieve this, we used 12-days-interval C-band Sentinel-1A Synthetic Aperture Radar (SAR) images as the main source to perform regular monitoring. Differential Interferometric SAR (D-InSAR) technique was applied to generate interferograms. Together with the accumulation of updated Sentinel-1A SAR images, time series interferograms were formed accordingly. For the purpose of observing surface stability over known construction sites, the interferograms and the unwrapped products could be used to identify the surface displacement occurring before and after specific events. In addition, Small Baseline Subset (SBAS) and Permanent Scatterers (PS) approaches combining a set of unwrapped D-InSAR interferograms were also applied to derive displacement velocities over long-term periods. For some cases, we conducted the ascending and descending mode time series analysis to decompose three surface migration vectors and to precisely identify the risk pattern. Regarding the extraction of suspicious unstable areas, we propose to develop an automatic pattern recognition algorithm for the identification of specific fringe patterns involving various potential risks. The detected fringes were tracked in the time series interferograms and

  13. Mars Mission Concepts: SAR and Solar Electric Propulsion

    Science.gov (United States)

    Elsperman, M.; Klaus, K.; Smith, D. B.; Clifford, S. M.; Lawrence, S. J.

    2012-12-01

    Introduction: The time has come to leverage technology advances (including advances in autonomous operation and propulsion technology) to reduce the cost and increase the flight rate of planetary missions, while actively developing a scientific and engineering workforce to achieve national space objectives. Mission Science at Mars: A SAR imaging radar offers an ability to conduct high resolution investigations of the shallow (system would enable the generation of false color images, resulting in useful science results, and the stereo data could be reduced into high-resolution Digital Elevation Models uniquely useful for exploration planning and science purposes. Since the SAR and the notional high-resolution stereo imaging system would be huge data volume producers - to maximize the science return we are currently considering the usage of laser communications systems; this notional spacecraft represents one pathway to evaluate the utility of laser communications in planetary exploration while providing useful science return.. Mission Concept: Using a common space craft for multiple missions reduces costs. Solar electric propulsion (SEP) provides the flexibility required for multiple mission objectives. SEP provides the greatest payload advantage albeit at the sacrifice of mission time. Our concept involves using a SEP enabled space craft (Boeing 702SP) with a highly capable SAR imager that also conducts autonomous rendezvous and docking experiments accomplished from Mars orbit. Our concept of operations is to launch on May 5, 2018 using a launch vehicle with 2000kg launch capacity with a C3 of 7.4. After reaching Mars it takes 145 days to spiral down to a 250 km orbit above the surface of Mars when Mars SAR operations begin. Summary/Conclusions: A robust and compelling Mars mission can be designed to meet the 2018 Mars launch window opportunity. Using advanced in-space power and propulsion technologies like High Power Solar Electric Propulsion provides enormous

  14. Computer viruses

    Science.gov (United States)

    Denning, Peter J.

    1988-01-01

    The worm, Trojan horse, bacterium, and virus are destructive programs that attack information stored in a computer's memory. Virus programs, which propagate by incorporating copies of themselves into other programs, are a growing menace in the late-1980s world of unprotected, networked workstations and personal computers. Limited immunity is offered by memory protection hardware, digitally authenticated object programs,and antibody programs that kill specific viruses. Additional immunity can be gained from the practice of digital hygiene, primarily the refusal to use software from untrusted sources. Full immunity requires attention in a social dimension, the accountability of programmers.

  15. Optimizing deep hyperthermia treatments: are locations of patient pain complaints correlated with modelled SAR peak locations?

    Science.gov (United States)

    Canters, R. A. M.; Franckena, M.; van der Zee, J.; van Rhoon, G. C.

    2011-01-01

    During deep hyperthermia treatment, patient pain complaints due to heating are common when maximizing power. Hence, there exists a good rationale to investigate whether the locations of predicted SAR peaks by hyperthermia treatment planning (HTP) are correlated with the locations of patient pain during treatment. A retrospective analysis was performed, using the treatment reports of 35 patients treated with deep hyperthermia controlled by extensive treatment planning. For various SAR indicators, the average distance from a SAR peak to a patient discomfort location was calculated, for each complaint. The investigated V0.1 closest (i.e. the part of the 0.1th SAR percentile closest to the patient complaint) performed the best, and leads to an average distance between the SAR peak and the complaint location of 3.9 cm. Other SAR indicators produced average distances that were all above 10 cm. Further, the predicted SAR peak location with V0.1 provides a 77% match with the region of complaint. The current study demonstrates that HTP is able to provide a global indication of the regions where hotspots during treatment will most likely occur. Further development of this technology is necessary in order to use HTP as a valuable toll for objective and advanced SAR steering. The latter is especially valid for applications that enable 3D SAR steering.

  16. Mining collapse monitoring with SAR imagery data: a case study of Datong mine, China

    Science.gov (United States)

    Zhao, Chaoying; Lu, Zhong; Zhang, Qin; Yang, Chengsheng; Zhu, Wu

    2014-01-01

    A mining-induced collapse is often characterized by large deformation gradient, spatial discontinuity, and temporal nonlinearity, resulting in the loss of interferometric SAR (InSAR) coherence and consequently subsidence information in areas of steep deformation gradients. In this study, we present different SAR deformation monitoring schemes to map the mining-induced subsidence and collapse. First, SAR data with different wavelengths, including C-band ERS-1, C-band Envisat ASAR, and X-band TerraSAR-X data, are used to highlight three mining subsidence stages and their temporal evolutions over Datong mine (China) in the past 20 years. Mining-induced subsidence over a region can be delimited from InSAR deformation maps, where InSAR coherence is lost over the area of peak subsidence. Second, in order to monitor the large-gradient surface deformation caused by underground mining activities, three SAR deformation monitoring schemes are proposed, including a full-resolution interferogram method, a "remove-restore" phase unwrapping method, and a fusion of phase and offset measurements. Then, taking the Datong coalfield as an example, we demonstrate the capabilities of these methods on mapping large-gradient deformation. Finally, we have found that over 80% of coalfields have deformed during the past 20 years. We conclude that the fusion of the InSAR phase and offset measurements can provide a reliable estimate of large-gradient mining-induced deformation.

  17. Spaceborne Synthetic Aperture Radar (SAR)Systems: State of the Art and Future Developments

    OpenAIRE

    Moreira, Alberto; Krieger, Gerhard

    2003-01-01

    This paper first summarizes the state of the art in spaceborne SAR systems and applications.The second part of this paper gives an overview of new concepts,techniques and technologies for future SAR systems,allowing an increase of flexibility in the SAR operation mode as well as a reduction in the overall system costs.Several innovative concepts and technologies as bi- and multi-static configurations,parasitic SAR,sparse aperture systems and digital beamforming will play an important role for...

  18. Structural Modeling and Analysis on Dynamic Characteristics of Antenna Pedestal in Airborne SAR

    Directory of Open Access Journals (Sweden)

    He Li-ping

    2012-06-01

    Full Text Available Finite element modeling and structural dynamic characteristics of antenna pedestal in airborne SAR were studied in this paper. The Finite element model of antenna pedestal in airborne SAR was set up on the basis of structural dynamic theory, then, the key technologies of dynamic simulation were pointed out, and the modal analysis and transient analysis were carried out. Simulation results show that the dynamic characteristics of antenna pedestal in airborne SAR can meet the requirements of servo bandwidth and structural strength. The fast finite element modeling and simulation method proposed in this paper are of great significance to the weight reducing design of antenna pedestal in airborne SAR.

  19. Improved Oceanographic Measurements with CryoSat SAR Altimetry

    Science.gov (United States)

    Cotton, David; Benveniste, Jérôme; Cipollini, Paolo; Andersen, Ole; Cancet, Mathilde; Ambrózio, Américo; Restano, Marco; Nilo Garcia, Pablo; Martin, Francisco

    2016-07-01

    The ESA CryoSat mission is the first space mission to carry a radar altimeter that can operate in Synthetic Aperture Radar "SAR" (or delay-Doppler) and interferometric SAR (SARin) modes. Studies on CryoSat data have analysed and confirmed the improved ocean measuring capability offered by SAR mode altimetry, through increased resolution and precision in sea surface height and wave height measurements, and have also added significantly to our understanding of the issues around the processing and interpretation of SAR altimeter echoes. We present work in four themes, building on work initiated in the CryoSat Plus for Oceans project (CP4O), each investigating different aspects of the opportunities offered by this new technology. The first two studies address the coastal zone, a critical region for providing a link between open-ocean and shelf sea measurements with those from coastal in-situ measurements, in particular tide gauges. Although much has been achieved in recent years through the Coastal Altimetry community, (http://www.coastalt.eu/community) there is a limit to the capabilities of pulse-limited altimetry, which often leaves an un-measured "white strip" right at the coastline. Firstly, a thorough analysis was made of the performance of "SAR" altimeter data (delay-Doppler processed) in the coastal zone. This quantified the performance, confirming the significant improvement over "conventional" pulse-limited altimetry. In the second study a processing scheme was developed with CryoSat SARin mode data to enable the retrieval of valid oceanographic measurements in coastal areas with complex topography. Thanks to further development of the algorithms, a new approach was achieved that can also be applied to SAR and conventional altimetry data (e.g., Sentinel-3, Jason series, Envisat). The third part of the project developed and evaluated improvements to the SAMOSA altimeter re-tracker that is implemented in the Sentinel-3 processing chain. The modifications to the

  20. SARS-CoV replicates in primary human alveolar type II cell cultures but not in type I-like cells

    Science.gov (United States)

    Mossel, Eric C.; Wang, Jieru; Jeffers, Scott; Edeen, Karen E.; Wang, Shuanglin; Cosgrove, Gregory P.; Funk, C. Joel; Manzer, Rizwan; Miura, Tanya A.; Pearson, Leonard D.; Holmes, Kathryn V.; Mason, Robert J.

    2008-01-01

    Severe acute respiratory syndrome (SARS) is a disease characterized by diffuse alveolar damage. We isolated alveolar type II cells and maintained them in a highly differentiated state. Type II cell cultures supported SARS-CoV replication as evidenced by RT-PCR detection of viral subgenomic RNA and an increase in virus titer. Virus titers were maximal by 24 hours and peaked at approximately 105 pfu/mL. Two cell types within the cultures were infected. One cell type was type II cells, which were positive for SP-A, SP-C, cytokeratin, a type II cell-specific monoclonal antibody, and Ep-CAM. The other cell type was composed of spindle-shaped cells that were positive for vimentin and collagen III and likely fibroblasts. Viral replication was not detected in type I-like cells or macrophages. Hence, differentiated adult human alveolar type II cells were infectible but alveolar type I-like cells and alveolar macrophages did not support productive infection. PMID:18022664

  1. Dynamic changes of serum SARS-Coronavirus IgG, pulmonary function and radiography in patients recovering from SARS after hospital discharge

    Directory of Open Access Journals (Sweden)

    Chen Liangan

    2005-01-01

    Full Text Available Abstract Objective The intent of this study was to examine the recovery of individuals who had been hospitalized for severe acute respiratory syndrome (SARS in the year following their discharge from the hospital. Parameters studied included serum levels of SARS coronavirus (SARS-CoV IgG antibody, tests of lung function, and imaging data to evaluate changes in lung fibrosis. In addition, we explored the incidence of femoral head necrosis in some of the individuals recovering from SARS. Methods The subjects of this study were 383 clinically diagnosed SARS patients in Beijing, China. They were tested regularly for serum levels of SARS-CoV IgG antibody and lung function and were given chest X-rays and/or high resolution computerized tomography (HRCT examinations at the Chinese PLA General Hospital during the 12 months that followed their release from the hospital. Those individuals who were found to have lung diffusion abnormities (transfer coefficient for carbon monoxide [DLCO] Findings Of all the subjects, 81.2% (311 of 383 patients tested positive for serum SARS-CoV IgG. Of those testing positive, 27.3% (85 of 311 patients were suffering from lung diffusion abnormities (DLCO Interpretation The lack of sero-positive SARS-CoV in some individuals suggests that there may have been some misdiagnosed cases among the subjects included in this study. Of those testing positive, the serum levels of SARS-CoV IgG antibody decreased significantly during the 12 months after hospital discharge. Additionally, we found that the individuals who had lung fibrosis showed some spontaneous recovery. Finally, some of the subjects developed femoral head necrosis.

  2. Genetic characterization of Measles Viruses in China, 2004

    Directory of Open Access Journals (Sweden)

    Yang Xuelei

    2008-10-01

    Full Text Available Abstract Genetic characterization of wild-type measles virus was studied using nucleotide sequencing of the C-terminal region of the N protein gene and phylogenetic analysis on 59 isolates from 16 provinces of China in 2004. The results showed that all of the isolates belonged to genotype H1. 51 isolates were belonged to cluster 1 and 8 isolates were cluster 2 and Viruses from both clusters were distributed throughout China without distinct geographic pattern. The nucleotide sequence and predicted amino acid homologies of the 59 H1 strains were 96.5%–100% and 95.7%–100%, respectively. The report showed that the transmission pattern of genotype H1 viruses in China in 2004 was consistent with ongoing endemic transmission of multiple lineages of a single, endemic genotype. Multiple transmission pathways leaded to multiple lineages within endemic genotype.

  3. The integration of Human Factors (HF) in the SAR process training course text

    Energy Technology Data Exchange (ETDEWEB)

    Ryan, T.G.

    1995-03-01

    This text provides the technical basis for a two-day course on human factors (HF), as applied to the Safety Analysis Report (SAR) process. The overall objective of this text and course is to: provide the participant with a working knowledge of human factors-related requirements, suggestions for doing a human safety analysis applying a graded approach, and an ability to demonstrate using the results of the human safety analysis, that human factors elements as defined by DOE (human factors engineering, procedures, training, oversight, staffing, qualifications), can support wherever necessary, nuclear safety commitments in the SAR. More specifically, the objectives of the text and course are: (1) To provide the SAR preparer with general guidelines for doing HE within the context of a graded approach for the SAR; (2) To sensitize DOE facility managers and staff, safety analysts and SAR preparers, independent reviewers, and DOE reviewers and regulators, to DOE Order 5480.23 requirements for HE in the SAR; (3) To provide managers, analysts, reviewers and regulators with a working knowledge of HE concepts and techniques within the context of a graded approach for the SAR, and (4) To provide SAR managers and DOE reviewers and regulators with general guidelines for monitoring and coordinating the work of preparers of HE inputs throughout the SAR process, and for making decisions regarding the safety relevance of HE inputs to the SAR. As a ready reference for implementing the human factors requirements of DOE Order 5480.22 and DOE Standard 3009-94, this course text and accompanying two-day course are intended for all persons who are involved in the SAR.

  4. Signal subspace change detection in averaged multi-look SAR imagery

    Science.gov (United States)

    Ranney, Kenneth; Soumekh, Mehrdad

    2005-05-01

    Modern Synthetic Aperture Radar (SAR) signal processing algorithms could retrieve accurate and subtle information regarding a scene that is being interrogated by an airborne radar system. An important reconnaissance problem that is being studied via the use of SAR systems and their sophisticated signal processing methods involves detecting changes in an imaged scene. In these problems, the user interrogates a scene with a SAR system at two different time points (e.g. different days); the resultant two SAR databases that we refer to as reference and test data, are used to determine where targets have entered or left the imaged scene between the two data acquisitions. For instance, X band SAR systems have the potential to become a potent tool to determine whether mines have been recently placed in an area. This paper describes an algorithm for detecting changes in averaged multi-look SAR imagery. Averaged multi-look SAR images are preferable to full aperture SAR reconstructions when the imaging algorithm is approximation based (e.g. polar format processing), or motion data are not accurate over a long full aperture. We study the application of a SAR detection method, known as Signal Subspace Processing, that is based on the principles of 2D adaptive filtering. We identify the change detection problem as a binary hypothesis-testing problem, and identify an error signal and its normalized version to determine whether i) there is no change in the imaged scene; or ii) a target has been added to the imaged scene. A statistical analysis of the error signal is provided to show its properties and merits. Results are provided for data collected by an X band SAR platform and processed to form non-coherently look-averaged SAR images.

  5. The integration of Human Factors (HF) in the SAR process training course text

    International Nuclear Information System (INIS)

    Ryan, T.G.

    1995-03-01

    This text provides the technical basis for a two-day course on human factors (HF), as applied to the Safety Analysis Report (SAR) process. The overall objective of this text and course is to: provide the participant with a working knowledge of human factors-related requirements, suggestions for doing a human safety analysis applying a graded approach, and an ability to demonstrate using the results of the human safety analysis, that human factors elements as defined by DOE (human factors engineering, procedures, training, oversight, staffing, qualifications), can support wherever necessary, nuclear safety commitments in the SAR. More specifically, the objectives of the text and course are: (1) To provide the SAR preparer with general guidelines for doing HE within the context of a graded approach for the SAR; (2) To sensitize DOE facility managers and staff, safety analysts and SAR preparers, independent reviewers, and DOE reviewers and regulators, to DOE Order 5480.23 requirements for HE in the SAR; (3) To provide managers, analysts, reviewers and regulators with a working knowledge of HE concepts and techniques within the context of a graded approach for the SAR, and (4) To provide SAR managers and DOE reviewers and regulators with general guidelines for monitoring and coordinating the work of preparers of HE inputs throughout the SAR process, and for making decisions regarding the safety relevance of HE inputs to the SAR. As a ready reference for implementing the human factors requirements of DOE Order 5480.22 and DOE Standard 3009-94, this course text and accompanying two-day course are intended for all persons who are involved in the SAR

  6. Virophages or satellite viruses?

    Science.gov (United States)

    Krupovic, Mart; Cvirkaite-Krupovic, Virginija

    2011-11-01

    It has been argued that the smaller viruses associated with giant DNA viruses are a new biological entity. However, Mart Krupovic and Virginija Cvirkaite-Krupovic argue here that these smaller viruses should be classified with the satellite viruses.

  7. NOAA high resolution sea surface winds data from Synthetic Aperture Radar (SAR) on the RADARSAT-2 satellite

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Synthetic Aperture Radar (SAR)-derived high resolution wind products are calculated from high resolution SAR images of normalized radar cross section (NRCS) of the...

  8. Hospice utilization during the SARS outbreak in Taiwan

    Directory of Open Access Journals (Sweden)

    Lin Ming-Hwai

    2006-08-01

    Full Text Available Abstract Background The severe acute respiratory syndrome (SARS epidemic threw the world into turmoil during the first half of 2003. Many subsequent papers have addressed its impact on health service utilization, but few have considered palliative (hospice care. The aim of the present study was to describe changes in hospice inpatient utilization during and after the SARS epidemic in 2003 in Taiwan. Methods The data sources were the complete datasets of inpatient admissions during 2002 and 2003 from the National Health Insurance Research Database. Before-and-after comparisons of daily and monthly utilizations were made. Hospice analyses were limited to those wards that offered inpatient services throughout these two years. The comparisons were extended to total hospital bed utilization and to patients who were still admitted to hospice wards during the peak period of the SARS epidemic. Results Only 15 hospice wards operated throughout the whole of 2002 and 2003. In 2003, hospice utilization began to decrease in the middle of April, reached a minimum on 25 May, and gradually recovered to the level of the previous November. Hospices showed a more marked reduction in utilization than all hospital beds (e.g. -52.5% vs. -19.9% in May 2003 and a slower recovery with a three-month lag. In total, 566 patients were admitted to hospice wards in May/June 2003, in contrast to 818 in May/June 2002. Gender, age and diagnosis distributions did not differ. Conclusion Hospice inpatient utilization in Taiwan was indeed more sensitive to the emerging epidemic than general inpatient utilization. A well-balanced network with seamless continuity of care should be ensured.

  9. GPU efficient SAR image despeckling using mixed norms

    Science.gov (United States)

    Özcan, Caner; Şen, Baha; Nar, Fatih

    2014-10-01

    Speckle noise which is inherent to Synthetic Aperture Radar (SAR) imaging obstructs various image exploitation tasks such as edge detection, segmentation, change detection, and target recognition. Therefore, speckle reduction is generally used as a first step which has to smooth out homogeneous regions while preserving edges and point scatterers. Traditional speckle reduction methods are fast and their memory consumption is insignificant. However, they are either good at smoothing homogeneous regions or preserving edges and point scatterers. State of the art despeckling methods are proposed to overcome this trade-off. However, they introduce another trade-off between denoising quality and resource consumption, thereby higher denoising quality requires higher computational load and/or memory consumption. In this paper, a local pixel-based total variation (TV) approach is proposed, which combines l2-norm and l1-norm in order to improve despeckling quality while keeping execution times reasonably short. Pixel-based approach allows efficient computation model with relatively low memory consumption. Their parallel implementations are also more efficient comparing to global TV approaches which generally require numerical solution of sparse linear systems. However, pixel-based approaches are trapped to local minima frequently hence despeckling quality is worse comparing to global TV approaches. Proposed method, namely mixed norm despeckling (MND), combines l2-norm and l1-norm in order to improve despeckling performance by alleviating local minima problem. All steps of the MND are parallelized using OpenMP on CPU and CUDA on GPU. Speckle reduction performance, execution time and memory consumption of the proposed method are shown using synthetic images and TerraSAR-X spot mode SAR images.

  10. One step closer to an experimental infection system for Hepatitis B Virus? --- the identification of sodium taurocholate cotransporting peptide as a viral receptor

    Directory of Open Access Journals (Sweden)

    Chen Pei-Jer

    2013-01-01

    Full Text Available Abstract Following the successful cloning of receptor for SARS coronavirus a few years ago, Dr. Wenhui Li and colleagues raised attention again by publishing a possible receptor for hepatitis B virus in eLife. We will briefly review the significance of this finding and the future prospects of hepatitis B research.

  11. a SAR Image Registration Method Based on Sift Algorithm

    Science.gov (United States)

    Lu, W.; Yue, X.; Zhao, Y.; Han, C.

    2017-09-01

    In order to improve the stability and rapidity of synthetic aperture radar (SAR) images matching, an effective method was presented. Firstly, the adaptive smoothing filtering was employed for image denoising in image processing based on Wallis filtering to avoid the follow-up noise is amplified. Secondly, feature points were extracted by a simplified SIFT algorithm. Finally, the exact matching of the images was achieved with these points. Compared with the existing methods, it not only maintains the richness of features, but a-lso reduces the noise of the image. The simulation results show that the proposed algorithm can achieve better matching effect.

  12. Robustness of Spann-Wilson segmentation on SAR imagery

    Science.gov (United States)

    Daida, Jason M.; Vesecky, John F.

    1992-01-01

    The performances of the Spann-Wilson algorithm on simulated synthetic aperture radar (SAR) images with varying degrees of speckle (one to four looks and varying amounts of white noise) is described. One hundred forty-eight test images are considered, of which the algorithm segmented most without any adjustment to the algorithm's parameters. The effect of speckle on fractal boundaries is studied. The effect of varying multiplicative and additive noise distributions for a fixed set of segmentation parameters is examined. The modified Spann-Wilson algorithm on four-look imagery is evaluated.

  13. Change detection in a series of Sentinel-1 SAR data

    DEFF Research Database (Denmark)

    Nielsen, Allan Aasbjerg; Conradsen, Knut; Skriver, Henning

    2017-01-01

    Based on an omnibus likelihood ratio test statistic for the equality of several variance-covariance matrices following the complex Wishart distribution with an associated p-value and a factorization of this test statistic, change analysis in a time series of seven multilook, dual polarization Sen...... Sentinel-1 SAR data in the covariance matrix representation (with diagonal elements only) is carried out. The omnibus test statistic and its factorization detect if and when change occurs. http://www.imm.dtu.dk/pubdb/p.php?6982....

  14. Application of SIR-C SAR to Hydrology

    Science.gov (United States)

    Engman, Edwin T.; ONeill, Peggy; Wood, Eric; Pauwels, Valentine; Hsu, Ann; Jackson, Tom; Shi, J. C.; Prietzsch, Corinna

    1996-01-01

    The progress, results and future plans regarding the following objectives are presented: (1) Determine and compare soil moisture patterns within one or more humid watersheds using SAR data, ground-based measurements, and hydrologic modeling; (2) Use radar data to characterize the hydrologic regime within a catchment and to identify the runoff producing characteristics of humid zone watersheds; and (3) Use radar data as the basis for scaling up from small scale, near-point process models to larger scale water balance models necessary to define and quantify the land phase of GCM's (Global Circulation Models).

  15. A new C-band SAR for ERS-1 underflights

    DEFF Research Database (Denmark)

    Madsen, Søren Nørvang; Skou, Niels; Christensen, Erik Lintz

    1990-01-01

    A high-resolution airborne C-band synthetic aperture radar (SAR) has been designed, built, and tested. The radar design based on digital technology to the largest possible extent, to make the system as adaptable as possible. This has resulted in a very flexible radar with variable resolution, swath...... width, and imaging geometry. Special attention was paid to system calibration when the system was designed. Design considerations are outlined, selected features are discussed in relation to the implementation (for example, the digital system, the aircraft, the antenna and its installation......, and the calibration system), and the first test results are given. The ongoing system developments and project plans are briefly described...

  16. Ship Detection in GF-3 NSC Mode SAR Images

    Directory of Open Access Journals (Sweden)

    Liu Zeyu

    2017-10-01

    Full Text Available GF-3, the first C-band full-polarimetric Synthetic Aperture Radar (SAR satellite with a space resolution up to 1 m, has multiple strip and scan imaging modes. In this paper, we propose a maritime ship detection algorithm that detects ship targets via pixel classification in a Bayesian framework and employ effective enhancement methods to improve detection performance based on the data characteristics. We compare and analyze the results of detection experiments using the proposed algorithm with those of several Constant False Alarm Rate (CFAR algorithms. The experimental results verify the effectiveness of the proposed algorithm.

  17. Object recognition of real targets using modelled SAR images

    Science.gov (United States)

    Zherdev, D. A.

    2017-12-01

    In this work the problem of recognition is studied using SAR images. The algorithm of recognition is based on the computation of conjugation indices with vectors of class. The support subspaces for each class are constructed by exception of the most and the less correlated vectors in a class. In the study we examine the ability of a significant feature vector size reduce that leads to recognition time decrease. The images of targets form the feature vectors that are transformed using pre-trained convolutional neural network (CNN).

  18. The impact of curved satellite tracks on SAR focusing

    DEFF Research Database (Denmark)

    Mohr, Johan Jacob; Madsen, Søren Nørvang

    2000-01-01

    This paper addresses the geometric effect of processing single look complex synthetic aperture radar (SAR) data to a reference squint angle different from that given by the center of the real antenna beam. For data acquired on a straight flight line, the required transformation of radar coordinat...... from one Doppler reference to another is independent of the target elevation but for data acquired from a satellite orbit over a rotating Earth that is not true. Also the effect of ignoring Earth rotation is addressed....

  19. Satellite SAR data assessment for Silk Road archaeological prospection

    Science.gov (United States)

    Chen, Fulong; Lasaponara, Rosa; Masini, Nicola; Yang, Ruixia

    2015-04-01

    The development of Synthetic Aperture Radar (SAR) in terms of multi-band, multi-polarization and high-resolution data, favored the application of this technology also in archaeology [1]. Different approaches based on both single and multitemporal data analysis, exploiting the backscattering and the penetration of radar data, have been used for a number of archaeological sites and landscapes [2-5]. Nevertheless, the capability of this technology in archaeological applications has so far not been fully assessed. It lacks a contribution aimed at evaluating the potential of SAR technology for the same study area by using different bands, spatial resolutions and data processing solutions. In the framework of the Chinese-Italian bilateral project "Smart management of cultural heritage sites in Italy and China: Earth Observation and pilot projects", we addressed some pioneering investigations to assess multi-mode (multi-band, temporal, resolution) satellite SAR data (including X-band TerraSAR, C-band Envisat and L-band ALOS PALSAR) in archaeological prospection of the Silk road [6]. The Silk Road, a series of trade and cultural transmission routes connecting China to Europe, is the witness of civilization and friendship between the East and West dated back to 2000 years ago, that left us various relics (e.g. lost cities) to be uncovered and investigated.. In particular, the assessment has been performed in the Xinjiang and Gansu section pf the Silk Road focusing on : i) the subsurface penetration capability of SAR data in the arid and semi-arid region ii) and sensitivity of SAR imaging geometry for the detection of relics As regards the point i) , apart from the soil moisture, the penetration is seriously restricted by the soil porosity. For instance, negligible penetration signs were detected in Yumen Frontier Pass either using X- or L-band SAR data due to the occurrence of Yardang landscape. As regards the point ii), the flight path of SAR images in parallel with the

  20. Phase History Decomposition for efficient Scatterer Classification in SAR Imagery

    Science.gov (United States)

    2011-09-15

    96] Liu, Qi, Yun Lin , Weixian Tan, Yanping Wang, Wen Hong, and Yirong Wu. “Study on SAR image formation for aspect-dependent scatterers”. Asian Pacific...Antennas and Prop., 55(9):2610–2617, 2007. [28] Chen, V.C. and H. Ling . Time-frequency transforms for radar imaging and signal analysis. Artech House...Sens., 45(12):4043 –4058, Dec. 2007. [118] Perlovsky, L., R. Ilin, R. Deming, R. Linnehan, and F. Lin . “Moving target detection and characterization with

  1. Matkapuhelinsäteily ja SAR-mittaukset

    OpenAIRE

    Malmberg, Mikko

    2009-01-01

    Tämän opinnäytetyöraportin tarkoituksena on toimia tietopankkina matkapuhelinsäteilystä ja sen vaikutuksista kiinnostuneille. Matkapuhelimien yleistymisen myötä on myös huoli matkapuhelinten turvallisuudesta kasvanut. Tämän työn tarkoituksena onkin koota yhteen matkapuhelinsäteilyyn liittyvää teoriaa, tietoa mahdollisista säteilyn aiheuttamista terveysvaikutuksista sekä kuvata altistumista tutkivien SAR-mittausten periaatteita. Matkapuhelinjärjestelmässä sekä tukiasema että matkapuhelime...

  2. Detection and strain differentiation of infectious bronchitis virus in tracheal tissues from experimentally infected chickens by reverse transcription-polymerase chain reaction. Comparison with an immunohistochemical technique

    DEFF Research Database (Denmark)

    Handberg, Kurt; Nielsen, O.L.; Pedersen, M.W.

    1999-01-01

    Oligonucleotide pairs were constructed for priming the amplification of fragments of nucleocapsid (N) protein and spike glycoprotein (S) genes of avian infectious bronchitis virus (IBV) by reverse transcription-polymerase chain reaction (RT-PCR). One oligonucleotide pair amplified a common segment...

  3. Validation of Forested Inundation Extent Revealed by L-Band Polarimetric and Interferometric SAR Data

    Science.gov (United States)

    Chapman, Bruce; Celi, Jorge; Hamilton, Steve; McDonald, Kyle

    2013-01-01

    UAVSAR, NASA's airborne Synthetic Aperture Radar (SAR), conducted an extended observational campaign in Central and South America in March 2013, primarily related to volcanic deformations along the Andean Mountain Range but also including a large number of flights studying other scientific phenomena. During this campaign, the L-Band SAR collected data over the Napo River in Ecuador. The objectives of this experiment were to acquire polarimetric and interferometric L-Band SAR data over an inundated tropical forest in Ecuador simultaneously with on-the-ground field work ascertaining the extent of inundation, and to then derive from this data a quantitative estimate for the error in the SAR-derived inundation extent. In this paper, we will first describe the processing and preliminary analysis of the SAR data. The polarimetric SAR data will be classified by land cover and inundation state. The interferometric SAR data will be used to identify those areas where change in inundation extent occurred, and to measure the change in water level between two observations separated by a week. Second, we will describe the collection of the field estimates of inundation, and have preliminary comparisons of inundation extent measured in the field field versus that estimated from the SAR data.

  4. SAR focusing of P-band ice sounding data using back-projection

    DEFF Research Database (Denmark)

    Kusk, Anders; Dall, Jørgen

    2010-01-01

    SAR processing can be applied to ice sounder data to improve along-track resolution and clutter suppression. This paper presents a time-domain back-projection technique for SAR focusing of ice sounder data. With this technique, variations in flight track and ice surface slope can be accurately ac...

  5. Airborne FM-CW SAR and Integrated Navigation System Data Fusion

    NARCIS (Netherlands)

    Lorga, J.F.M.; Meta, A.; Wit, J.J.M. de; Mulder, J.A.

    2005-01-01

    The combination of compact FM-CW radar technology and high resolution SAR pro- cessing techniques should pave the way for the development of a small and cost e®ective imaging radar with high resolution. However, airborne SAR is a very novel application for FM-CW radars. In order to investigate the

  6. Motion Compensation for a High Resolution Ka-Band Airborne FM-CW SAR

    NARCIS (Netherlands)

    Meta, A; Lorga, J.F.M.; Wit, J.J.M. de; Hoogeboom, P.

    2005-01-01

    Airborne synthetic aperture radar is a promising new application for FM-CW radars. At the IRCTR, an operational demonstrator system has been developed in order to investigate the practicability of FM-CW SAR and to prove that an FM-CW SAR system can be operated in an efficient manner from a small

  7. Development of a High Resolution Airborne Millimeter Wave FM-CW SAR

    NARCIS (Netherlands)

    Meta, A.; Wit, J.J.M. de; Hoogeboom, P.

    2004-01-01

    The combination of compact FM-CW radar technology and high resolution SAR processing techniques should pave the way for the development of a small, lightweight and cost effective imaging radar. In the field of airborne earth observation, SAR is however a novel application for FM-CW radars. At IRCTR

  8. Monitoring of Land-Surface Deformation in the Karamay Oilfield, Xinjiang, China, Using SAR Interferometry

    Directory of Open Access Journals (Sweden)

    Yusupujiang Aimaiti

    2017-07-01

    Full Text Available Synthetic Aperture Radar (SAR interferometry is a technique that provides high-resolution measurements of the ground displacement associated with various geophysical processes. To investigate the land-surface deformation in Karamay, a typical oil-producing city in the Xinjiang Uyghur Autonomous Region, China, Advanced Land Observing Satellite (ALOS Phased Array L-band Synthetic Aperture Radar (PALSAR data were acquired for the period from 2007 to 2009, and a two-pass differential SAR interferometry (D-InSAR process was applied. The experimental results showed that two sites in the north-eastern part of the city exhibit a clear indication of land deformation. For a further evaluation of the D-InSAR result, the Persistent Scatterer (PS and Small Baseline Subset (SBAS-InSAR techniques were applied for 21 time series Environmental Satellite (ENVISAT C-band Advanced Synthetic Aperture Radar (ASAR data from 2003 to 2010. The comparison between the D-InSAR and SBAS-InSAR measurements had better agreement than that from the PS-InSAR measurement. The maximum deformation rate attributed to subsurface water injection for the period from 2003 to 2010 was up to approximately 33 mm/year in the line of sight (LOS direction. The interferometric phase change from November 2007 to June 2010 showed a clear deformation pattern, and the rebound center has been expanding in scale and increasing in quantity.

  9. Airborne SAR Real-time Imaging Algorithm Design and Implementation with CUDA on NVIDIA GPU

    Directory of Open Access Journals (Sweden)

    Meng Da-di

    2013-12-01

    Full Text Available Synthetic Aperture Radar (SAR image processing requires huge computation amount. Traditionally, this task runs on the workstation or server based on Central Processing Unit (CPU and is rather time-consuming, hence real-time processing of SAR data is impossible. Based on Compute Unified Device Architecture (CUDA technology, a new plan of SAR imaging algorithm operated on NVIDIA Graphic Processing Unit (GPU is proposed. The new proposal makes it possible that the data processing procedure and CPU/GPU data exchanging execute concurrently, especially when SAR data size exceeds total GPU global memory size. Multi-GPU is suitably supported by the new proposal and all of computational resources are fully exploited. It is shown by experiment on NVIDIA K20C and INTEL E5645 that the proposed solution accelerates SAR data processing by tens of times. Consequently, the GPU based SAR processing system with the proposed solution embedded is much more power saving and portable, which makes it qualified to be a real-time SAR data processing system. Experiment shows that SAR data of 36 Mega points can be processed in real-time per second by K20C with the new solution equipped.

  10. Offshore wind resource mapping for Europe by Synthetic Aperture Radar (SAR) satellite data

    DEFF Research Database (Denmark)

    Hasager, Charlotte Bay; Badger, Merete

    2015-01-01

    of satellite remote sensing observations and atmospheric modelling. The satellite data include Synthetic Aperture Radar (SAR) from the European Space Agency from Envisat and the Copernicus mission Sentinel-1. SAR has the advantage of high spatial resolution such that we can cover near-coastal areas where many...

  11. Perceived Threat, Risk Perception, and Efficacy Beliefs Related to SARS and Other (Emerging) Infectious Diseases

    DEFF Research Database (Denmark)

    de Zwart, Onno; Veldhuijzen, Irene; Elam, Gillian

    2009-01-01

    -efficacy for SARS were higher in Asia compared to Europe. In multiple linear regression analyses, country was strongly associated with perceived threat. CONCLUSIONS: The relatively high perceived threat for SARS indicates that it is seen as a public health risk and offers a basis for communication in case...

  12. Focusing resonance signatures in ultra-wideband SAR images by allpass filtering.

    Science.gov (United States)

    Rau, R; McClellan, J H

    2000-01-01

    This correspondence shows that resonance signatures in ultra-wideband synthetic aperture radar (SAR) images, which are smeared out due to their late arrival time, can be focused and extracted by postfiltering the SAR images with special two-dimensional (2-D) allpass filters. A design algorithm for FIR approximations to the desired allpass filters based on radial slice approximations (RSA) is presented.

  13. PS-InSAR Monitoring of Landslide Activity in the Black Sea Coast of the Caucasus

    NARCIS (Netherlands)

    Kiseleva, E.; Mikhailov, V.; Smolyaninova, E.; Dmitriev, P.; Golubev, V.; Timoshkina, E.; Hooper, A.; Samiei-Esfahany, S.; Hanssen, R.F.

    2014-01-01

    The landslide activity in the area of Bolshoy Sochi (Big Sochi) situated at the Black Sea coast of the Great Caucasus has been studied using the StaMPS PS-InSAR method. We incorporated three sets of radar images from the satellites with different wavelengths ALOS, Envisat and Terra-SAR-X from both

  14. Evaluation of SAMOSA3 adapted retracker using Cryosat-2 SAR altimetry data over the Arctic ocean

    DEFF Research Database (Denmark)

    Jain, Maulik; Martin-Puig, Cristina; Andersen, Ole Baltazar

    2014-01-01

    European Space Agency's Cryosat-2 comes with the first ever SAR (Synthetic Aperture Radar) altimeter onboard a satellite. In this work precise sea surface heights and gravity fields are determined using Cryosat-2 SAR data. These determinations through satellite altimetry are difficult in the Arct...

  15. Modeling the structure of SARS 3a transmembrane protein using a ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences; Volume 127; Issue 12. Modeling the structure of SARS 3a transmembrane protein using a minimum unfavorable contact approach. S Ramakrishna ... Keywords. Membrane protein modeling; ion channel; transmembrane helices; viroporin; molecular dynamics; SARS 3a.

  16. Evaluation of high resolution space borne SAR for man-made target characterisation

    NARCIS (Netherlands)

    Broek, A.C. van den; Dekker, R.J.

    2008-01-01

    Due to its all-weather feature SAR is a very suitable sensor for monitoring at regular time intervals and therefore for monitoring changes on the Earth’s surface. Radar satellites with resolutions down to 1 meter, such as TerraSAR- X are becoming operational implying that detailed changes can now be

  17. An econometric analysis of SARS and Avian flu on international tourist arrivals to Asia

    NARCIS (Netherlands)

    M.J. McAleer (Michael); B-W. Huang (Bing-Wen); H-I. Kuo (Hsiao-I); C-C. Chen (Chi-Chung); C-L. Chang (Chia-Lin)

    2008-01-01

    textabstractThis paper compares the impacts of SARS and human deaths arising from Avian Flu on international tourist arrivals to Asia. The effects of SARS and human deaths from Avian Flu will be compared directly according to human deaths. The nature of the short run and long run relationship is

  18. SarA is a negative regulator of Staphylococcus epidermidis biofilm formation

    DEFF Research Database (Denmark)

    Martin, Christer; Heinze, C.; Busch, M.

    2012-01-01

    to biofilm formation in mutant 1585ΔsarA. Increased eDNA amounts indirectly resulted from up-regulation of metalloprotease SepA, leading to boosted processing of major autolysin AtlE, in turn inducing augmented autolysis and release of chromosomal DNA. Hence, this study identifies sarA as a negative...

  19. B1-based SAR reconstruction using contrast source inversion-electric properties tomography (CSI-EPT)

    NARCIS (Netherlands)

    Balidemaj, Edmond; van den Berg, Cornelis A T; van Lier, A.L.H.M.W.; Nederveen, Aart J; Stalpers, Lukas J A; Crezee, Hans; Remis, Rob F

    Specific absorption rate (SAR) assessment is essential for safety purposes during MR acquisition. Online SAR assessment is not trivial and requires, in addition, knowledge of the electric tissue properties and the electric fields in the human anatomy. In this study, the potential of the recently

  20. B1-based SAR reconstruction using contrast source inversion-electric properties tomography (CSI-EPT)

    NARCIS (Netherlands)

    Balidemaj, Edmond; van den Berg, Cornelis A. T.; van Lier, Astrid L. H. M. W.; Nederveen, Aart J.; Stalpers, Lukas J. A.; Crezee, Hans; Remis, Rob F.

    2017-01-01

    Specific absorption rate (SAR) assessment is essential for safety purposes during MR acquisition. Online SAR assessment is not trivial and requires, in addition, knowledge of the electric tissue properties and the electric fields in the human anatomy. In this study, the potential of the recently

  1. B1-based SAR reconstruction using contrast source inversion–electric properties tomography (CSI-EPT)

    NARCIS (Netherlands)

    Balidemaj, E.; van den Berg, CAT; van Lier, ALHMW; Nederveen, AJ; Stalpers, LJA; Crezee, H; Remis, R.F.

    2016-01-01

    Specific absorption rate (SAR) assessment is essential for safety purposes during MR acquisition. Online SAR assessment is not trivial and requires, in addition, knowledge of the electric tissue properties and the electric fields in the human anatomy. In this study, the potential of the recently

  2. SAR Study of Mobile Phones as a function of Antenna Q

    DEFF Research Database (Denmark)

    Bahramzy, Pevand; Svendsen, Simon; Jagielski, Ole

    2015-01-01

    High-Q tunable antennas are good alternatives to low-Q passive antennas because the antenna size can be smaller while covering the required long-term evolution (LTE) frequency bands. However, among other things, specific absorption rate (SAR) can become a challenge due to the relative high curren...... SAR values depend on total losses of the mock-up (MU)....

  3. 76 FR 8847 - Proposed Information Collection (Lenders Staff Appraisal Reviewer (SAR) Application) Activity...

    Science.gov (United States)

    2011-02-15

    ... AFFAIRS Proposed Information Collection (Lenders Staff Appraisal Reviewer (SAR) Application) Activity... solicits comments information needed to certify a lender's nominee as a VA Staff Appraisal Reviewer. DATES...: Lenders Staff Appraisal Reviewer (SAR) Application, VA Form 26-0785. OMB Control Number: 2900-0658. Type...

  4. Improving peak local SAR prediction in parallel transmit using in situ S-matrix measurements

    NARCIS (Netherlands)

    Restivo, Matthew; Raaijmakers, AJE; van den Berg, CAT; Luijten, Peter; Hoogduin, Hans

    PURPOSE: Peak local specific absorption rate (pSAR10g) is an important parameter used to determine patient safety during radiofrequency transmission. pSAR10g predictions for parallel transmit MRI are affected by the level of coupling exhibited by a modeled array in the simulation environment.

  5. Segmentation of Polarimetric SAR Images Usig Wavelet Transformation and Texture Features

    Science.gov (United States)

    Rezaeian, A.; Homayouni, S.; Safari, A.

    2015-12-01

    Polarimetric Synthetic Aperture Radar (PolSAR) sensors can collect useful observations from earth's surfaces and phenomena for various remote sensing applications, such as land cover mapping, change and target detection. These data can be acquired without the limitations of weather conditions, sun illumination and dust particles. As result, SAR images, and in particular Polarimetric SAR (PolSAR) are powerful tools for various environmental applications. Unlike the optical images, SAR images suffer from the unavoidable speckle, which causes the segmentation of this data difficult. In this paper, we use the wavelet transformation for segmentation of PolSAR images. Our proposed method is based on the multi-resolution analysis of texture features is based on wavelet transformation. Here, we use the information of gray level value and the information of texture. First, we produce coherency or covariance matrices and then generate span image from them. In the next step of proposed method is texture feature extraction from sub-bands is generated from discrete wavelet transform (DWT). Finally, PolSAR image are segmented using clustering methods as fuzzy c-means (FCM) and k-means clustering. We have applied the proposed methodology to full polarimetric SAR images acquired by the Uninhabited Aerial Vehicle Synthetic Aperture Radar (UAVSAR) L-band system, during July, in 2012 over an agricultural area in Winnipeg, Canada.

  6. The SARS coronavirus spike glycoprotein is selectively recognized by lung surfactant protein D and activates macrophages

    DEFF Research Database (Denmark)

    Leth-Larsen, Rikke; Zhong, Fei; Chow, Vincent T K

    2007-01-01

    The severe acute respiratory syndrome coronavirus (SARS-CoV) infects host cells with its surface glycosylated spike-protein (S-protein). Here we expressed the SARS-CoV S-protein to investigate its interactions with innate immune mechanisms in the lung. The purified S-protein was detected as a 210 k...

  7. InSAR elevation bias caused by penetration into uniform volumes

    DEFF Research Database (Denmark)

    Dall, Jørgen

    2007-01-01

    Natural media like cold-land ice, vegetation, and dry sand are subject to a substantial penetration at microwave frequencies. For such media, the synthetic aperture radar (SAR) ase center is located below the surface, and consequently, the surface elevation determined with SAR interferometry (In...

  8. SEGMENTATION OF POLARIMETRIC SAR IMAGES USIG WAVELET TRANSFORMATION AND TEXTURE FEATURES

    Directory of Open Access Journals (Sweden)

    A. Rezaeian

    2015-12-01

    Full Text Available Polarimetric Synthetic Aperture Radar (PolSAR sensors can collect useful observations from earth’s surfaces and phenomena for various remote sensing applications, such as land cover mapping, change and target detection. These data can be acquired without the limitations of weather conditions, sun illumination and dust particles. As result, SAR images, and in particular Polarimetric SAR (PolSAR are powerful tools for various environmental applications. Unlike the optical images, SAR images suffer from the unavoidable speckle, which causes the segmentation of this data difficult. In this paper, we use the wavelet transformation for segmentation of PolSAR images. Our proposed method is based on the multi-resolution analysis of texture features is based on wavelet transformation. Here, we use the information of gray level value and the information of texture. First, we produce coherency or covariance matrices and then generate span image from them. In the next step of proposed method is texture feature extraction from sub-bands is generated from discrete wavelet transform (DWT. Finally, PolSAR image are segmented using clustering methods as fuzzy c-means (FCM and k-means clustering. We have applied the proposed methodology to full polarimetric SAR images acquired by the Uninhabited Aerial Vehicle Synthetic Aperture Radar (UAVSAR L-band system, during July, in 2012 over an agricultural area in Winnipeg, Canada.

  9. C-band solid state dual polarization T/R modules for airborne SAR systems

    NARCIS (Netherlands)

    Vermeulen, B.C.B.; Koomen, P.J.; Hoogeboom, P.; Snoeij, P.; Pouwels, H.

    1996-01-01

    The use of distributed power in a, on a phased array antenna based, SAR system offers new possibilities for the system operation. As a preparation for future spaceborne SAR systems using solid state transmitters with electronically steerable phased array antenna, the PHARUS system has been

  10. Development of a Small Phased Array SAR-MTI System for Tactical UAV

    NARCIS (Netherlands)

    Rossum, W.L. van; Grooters, R.; Halsema, D. van; Lorga, J.F.M.; Otten, M.P.G.; Vermeulen, B.C.B.; Vlothuizen, W.J.

    2005-01-01

    A small SAR-MTI system is being developed at TNO, aimed at deployment on tactical UAV, such as the SPERWER, in use with the Royal Netherlands Army. The system makes use of modern front-end technology, to provide flexible SAR imaging and MTI modes. Major design goals are 40 kg weight, 500 W power

  11. The Design and Development of a Polarimetric Phased Array Airborne SAR Sensor

    NARCIS (Netherlands)

    Snoeij, P.; Pouwels, H.; Koomen, P.J.; Vermeulen, B.C.B.; Hoogeboom, P.

    1996-01-01

    A polarimetric C-band airborne SAR has been developed in the Netherlands. The system makes use of a phased array antenna with solid state amplifiers. The project consists of two phases, a definition phase and a realization phase. The definition phase consisted of the actual realization of a SAR

  12. Reflection on SARS Precautions in a Severe Intellectual Disabilities Hospital in Hong Kong

    Science.gov (United States)

    Wong, S. Y.; Lim, W. W. C.; Que, T. L.; Au, D. M. Y.

    2005-01-01

    Hong Kong went through a battle with a new respiratory disease, severe acute respiratory syndrome (SARS), from March to June 2003. All clinical settings, including rehabilitative and infirmary setting, have actively involved in fighting against the infection. The intent of this paper was to reflect on the SARS precautionary measures that had been…

  13. InSAR datum connection using GNSS-augmented radar transponders

    NARCIS (Netherlands)

    Mahapatra, P.S.; van der Marel, H.; van Leijen, F.J.; Samiei Esfahany, S.; Klees, R.; Hanssen, R.F.

    2017-01-01

    Deformation estimates from Interferometric Synthetic
    Aperture Radar (InSAR) are relative: they form a ‘free’
    network referred to an arbitrary datum, e.g. by assuming a reference
    point in the image to be stable. However, some applications
    require ‘absolute’ InSAR estimates, i.e.

  14. Computer Viruses. Technology Update.

    Science.gov (United States)

    Ponder, Tim, Comp.; Ropog, Marty, Comp.; Keating, Joseph, Comp.

    This document provides general information on computer viruses, how to help protect a computer network from them, measures to take if a computer becomes infected. Highlights include the origins of computer viruses; virus contraction; a description of some common virus types (File Virus, Boot Sector/Partition Table Viruses, Trojan Horses, and…

  15. Risk factors for SARS transmission from patients requiring intubation: a multicentre investigation in Toronto, Canada.

    Directory of Open Access Journals (Sweden)

    Janet Raboud

    Full Text Available BACKGROUND: In the 2003 Toronto SARS outbreak, SARS-CoV was transmitted in hospitals despite adherence to infection control procedures. Considerable controversy resulted regarding which procedures and behaviours were associated with the greatest risk of SARS-CoV transmission. METHODS: A retrospective cohort study was conducted to identify risk factors for transmission of SARS-CoV during intubation from laboratory confirmed SARS patients to HCWs involved in their care. All SARS patients requiring intubation during the Toronto outbreak were identified. All HCWs who provided care to intubated SARS patients during treatment or transportation and who entered a patient room or had direct patient contact from 24 hours before to 4 hours after intubation were eligible for this study. Data was collected on patients by chart review and on HCWs by interviewer-administered questionnaire. Generalized estimating equation (GEE logistic regression models and classification and regression trees (CART were used to identify risk factors for SARS transmission. RESULTS: 45 laboratory-confirmed intubated SARS patients were identified. Of the 697 HCWs involved in their care, 624 (90% participated in the study. SARS-CoV was transmitted to 26 HCWs from 7 patients; 21 HCWs were infected by 3 patients. In multivariate GEE logistic regression models, presence in the room during fiberoptic intubation (OR = 2.79, p = .004 or ECG (OR = 3.52, p = .002, unprotected eye contact with secretions (OR = 7.34, p = .001, patient APACHE II score > or = 20 (OR = 17.05, p = .009 and patient Pa0(2/Fi0(2 ratio < or = 59 (OR = 8.65, p = .001 were associated with increased risk of transmission of SARS-CoV. In CART analyses, the four covariates which explained the greatest amount of variation in SARS-CoV transmission were covariates representing individual patients. CONCLUSION: Close contact with the airway of severely ill patients and failure of infection control practices to prevent exposure

  16. Performance Analysis for Airborne Interferometric SAR Affected by Flexible Baseline Oscillation

    Directory of Open Access Journals (Sweden)

    Liu Zhong-sheng

    2014-04-01

    Full Text Available The airborne interferometric SAR platform suffers from instability factors, such as air turbulence and mechanical vibrations during flight. Such factors cause the oscillation of the flexible baseline, which leads to significant degradation of the performance of the interferometric SAR system. This study is concerned with the baseline oscillation. First, the error of the slant range model under baseline oscillation conditions is formulated. Then, the SAR complex image signal and dual-channel correlation coefficient are modeled based on the first-order, second-order, and generic slant range error. Subsequently, the impact of the baseline oscillation on the imaging and interferometric performance of the SAR system is analyzed. Finally, simulations of the echo data are used to validate the theoretical analysis of the baseline oscillation in the airborne interferometric SAR.

  17. Investigation of the Capability of Compact Polarimetric SAR Interferometry to Estimate Forest Height

    Science.gov (United States)

    Zhang, Hong; Xie, Lei; Wang, Chao; Chen, Jiehong

    2013-08-01

    The main objective of this paper is to investigate the capability of compact Polarimetric SAR Interferometry (C-PolInSAR) on forest height estimation. For this, the pseudo fully polarimetric interferomteric (F-PolInSAR) covariance matrix is firstly reconstructed, then the three- stage inversion algorithm, hybrid algorithm, Music and Capon algorithm are applied to both C-PolInSAR covariance matrix and pseudo F-PolInSAR covariance matrix. The availability of forest height estimation is demonstrated using L-band data generated by simulator PolSARProSim and X-band airborne data acquired by East China Research Institute of Electronic Engineering, China Electronics Technology Group Corporation.

  18. A Refined Algorithm On The Estimation Of Residual Motion Errors In Airborne SAR Images

    Science.gov (United States)

    Zhong, Xuelian; Xiang, Maosheng; Yue, Huanyin; Guo, Huadong

    2010-10-01

    Due to the lack of accuracy in the navigation system, residual motion errors (RMEs) frequently appear in the airborne SAR image. For very high resolution SAR imaging and repeat-pass SAR interferometry, the residual motion errors must be estimated and compensated. We have proposed a new algorithm before to estimate the residual motion errors for an individual SAR image. It exploits point-like targets distributed along the azimuth direction, and not only corrects the phase, but also improves the azimuth focusing. But the required point targets are selected by hand, which is time- and labor-consuming. In addition, the algorithm is sensitive to noises. In this paper, a refined algorithm is proposed aiming at these two shortcomings. With real X-band airborne SAR data, the feasibility and accuracy of the refined algorithm are demonstrated.

  19. Methods of InSAR atmosphere correction for volcano activity monitoring

    Science.gov (United States)

    Gong, W.; Meyer, F.; Webley, P.W.; Lu, Z.

    2011-01-01

    When a Synthetic Aperture Radar (SAR) signal propagates through the atmosphere on its path to and from the sensor, it is inevitably affected by atmospheric effects. In particular, the applicability and accuracy of Interferometric SAR (InSAR) techniques for volcano monitoring is limited by atmospheric path delays. Therefore, atmospheric correction of interferograms is required to improve the performance of InSAR for detecting volcanic activity, especially in order to advance its ability to detect subtle pre-eruptive changes in deformation dynamics. In this paper, we focus on InSAR tropospheric mitigation methods and their performance in volcano deformation monitoring. Our study areas include Okmok volcano and Unimak Island located in the eastern Aleutians, AK. We explore two methods to mitigate atmospheric artifacts, namely the numerical weather model simulation and the atmospheric filtering using Persistent Scatterer processing. We investigate the capability of the proposed methods, and investigate their limitations and advantages when applied to determine volcanic processes. ?? 2011 IEEE.

  20. OPTICAL-TO-SAR IMAGE REGISTRATION BASED ON GAUSSIAN MIXTURE MODEL

    Directory of Open Access Journals (Sweden)

    H. Wang

    2012-07-01

    Full Text Available Image registration is a fundamental in remote sensing applications such as inter-calibration and image fusion. Compared to other multi sensor image registration problems such as optical-to-IR, the registration for SAR and optical images has its specials. Firstly, the radiometric and geometric characteristics are different between SAR and optical images. Secondly, the feature extraction methods are heavily suffered with the speckle in SAR images. Thirdly, the structural information is more useful than the point features such as corners. In this work, we proposed a novel Gaussian Mixture Model (GMM based Optical-to-SAR image registration algorithm. The feature of line support region (LSR is used to describe the structural information and the orientation attributes are added into the GMM to avoid Expectation Maximization (EM algorithm falling into local extremum in feature sets matching phase. Through the experiments it proves that our algorithm is very robust for optical-to- SAR image registration problem.