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Sample records for santa ines ewes

  1. Nursing regimens: effects on body condition, return to postpartum ovarian cyclicity in Santa Ines ewes, and performance of lambs.

    Science.gov (United States)

    Ascari, I J; Alves, A C; Pérez, J R O; Lima, R R; Garcia, I F F; Nogueira, G P; Junqueira, F B; Castro, T R; Aziani, W L B; Alves, N G

    2013-08-01

    The effects of nursing regimens on the body condition, onset of ovarian cyclicity postpartum and weaning weight of lambs were assessed in Santa Ines ewes. Thirty-two ewes were blocked according to parity, number of lambs, and body weight at lambing and within each block randomly allocated to treatments: continuous nursing (CN), controlled nursing (CN2) with two daily feedings for an hour after the 10th day postpartum, or early weaning (EW) with total separation from the lambs after the 10th day. The animals were evaluated from the 12th day postpartum until the first estrus or until 60th day. The dry matter and nutrients intake did not differ among treatments (P>0.05) but did differ over time (P0.05) among the treatments. The percentage of ovulation until 30th day was greater (PSanta Ines ewes, with the advantages of simpler management and higher lamb weaning weights.

  2. Single-port laparoscopic ovariectomy using a pre-tied loop ligature in Santa Ines ewes

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    Felipe Farias Pereira da Câmara Barros

    2015-11-01

    Full Text Available ABSTRACT: The aim of the study was to develop and assess the feasibility, postoperative pain and inflammatory response of the single-port laparoscopic ovariectomy in ewes, using a simple pre-tied loop ligature technique. Pre-tied Meltzer's knot was employed for prophylactic hemostasis of the ovarian pedicle. Slipknot was inserted within the abdominal cavity through a 14-gauge needle and tied surrounding the ovarian pedicle. Mean surgical time, manipulation, ligature and resection of each ovary and anesthesia time were 63±20, 20±10 and 91±26 minutes, respectively. No bleeding occurred during the surgeries. Ewes showed low scores pain (0.5±0.5 at all time-points. Postsurgical plasma fibrinogen was within the normal range for sheep specie at all time-points. The ewes showed a significant weight gain in comparison to the basal scaling (one day before the surgery. Single-port laparoscopic ovariectomy using a pre-tied loop ligature is feasible in the ovine specie and provided minimal postoperative distress and quick weight gain.

  3. Effect of pre and post-slaughter processes on meat characteristics of Santa Ines ewes discarded due to age

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    Luiz Eduardo dos Santos

    2012-09-01

    Full Text Available The effects of body condition recovery (BC, carcass electrical stimulation (ES, aging time (AT 7 - 14 days, and calcium chloride injection on the meat characteristics of Santa Inês ewes (±5 years old slaughtered immediately after weaning or after the body condition recovery period were studied. The carcass temperature, pH, shear force (SF, cooking loss (CL, meat color (L*, a*, b*, and meat tenderness were evaluated. A completely randomized design in a 2 × 2 × 2 × 3 (BC × ES × CaCl2 × AT factorial arrangement was used, and the sensory tenderness data were analyzed using the table of Minimum Number of Correct Answers for the Duo-Trio test. The body condition recovery reduces the shear force in 8%, increasing their tenderness. Electrical stimulation reduced the shear force (24% and did not change the other parameters. The aging time (7 or 14 days decreased the shear force (18-26%, effect that was enhanced by electrical stimulation, and it darkened the meat reducing lightness (L* and increasing yellowness (b*. The treatment with CaCl2 was the most effective in tenderizing meat by reducing the shear force ( 35%; increasing the cooking loss (4.5%; and increasing L* and b* lightening the meat. The sensory evaluation of tenderness corroborates the findings of the experimental evaluation regarding the effect of the treatment with CaCl2 on the meat quality improvement. It was concluded that the treatments improve meat characteristics achieving better results when applied together.

  4. Efeito da suplementação alimentar nas respostas fisiológicas, hormonais e sanguíneas de ovelhas Santa Inês, Ile de France e Texel = Effect of supplementary feeding on physiological, hormonal and blood responses of Santa Ines, Ile de France and Texel ewes

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    Fábio José Lourenço

    2009-10-01

    Full Text Available Avaliou-se a suplementação de proteína (12% de proteína bruta (PB (T1 e 16% de PB (T2 na temperatura retal (TR, frequências respiratória (FR e cardíaca (FC, glicose (Gl, albumina (Alb, proteínas totais (PT, triiodotironina (T3 e tiroxina (T4 de 16 ovelhas Santa Inês, 16 Texel e 15 Ile de France. A FR não diferiu no T1 e T2 na Santa Inês e Ile de France, sendo maior na Texel no T2. FR aumentou na primavera, na Texel, seguida da Ile de France e pela Santa Inês e caiu no outono para Santa Inês e Ile de France. FR foi maior à tarde, na Texel, na Ile de France e na Santa Inês. Maior FC na Santa Inês e Texel no T1 e menor na Ile de France. FC na Santa Inês foi superior nas estações do ano, e na primavera maior para todas as raças. Maior Gl, PT, Alb e T3 na Santa Inês, e iguais para Texel e Ile de France. T3 maior na Santa Inês no inverno; na Texel maior no inverno e primavera, sem diferenças para Ile de France. Gl, T3 e T4 iguais no T1 e T2, e a PT e Alb maiores no T2.We evaluated the supplemental protein (12% crude protein (CP (T1 and 16% CP (T2 in rectal temperature (RT, respiratory rate (RR and heart rate (HR, glucose (Gl, albumin (Alb, total protein (TP, triiodothyronine (T3 and thyroxine (T4 in 16 Santa Ines, 16 Texel and 15 Ile de France ewes. The RR was not differing in T1 and T2 in Santa Ines and Ile de France, being higher in Texel in T2. FR increased in the spring, in the Texel, followed by Ile de France and Santa Ines, and decreased in fall in Santa Ines and Ile de France. RR was higher in the afternoon, in the Texel, in Ile de France and Santa Ines. Higher HR in Santa Ines and Texel in T1, and smaller in Ile de France. HR in Santa Ines was higher in the seasons, and spring higher for all breeds. Greater Gl, TP, Alb and T3 in Santa Ines, and equal for Texel and Ile de France. T3 higher for the Santa Ines in the winter; in Texel higher in winter and spring; no differences for Ile de France. Gl, T3 and T4 were similar

  5. Efeito da suplementação alimentar nas respostas fisiológicas, hormonais e sanguíneas de ovelhas Santa Inês, Ile de France e Texel - DOI: 10.4025/actascianimsci.v31i4.4920 Effect of supplementary feeding on physiological, hormonal and blood responses of Santa Ines, Ile de France and Texel ewes - DOI: 10.4025/actascianimsci.v31i4.4920

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    Fábio José Lourenço

    2009-10-01

    Full Text Available Avaliou-se a suplementação de proteína (12% de proteína bruta (PB (T1 e 16% de PB (T2 na temperatura retal (TR, frequências respiratória (FR e cardíaca (FC, glicose (Gl, albumina (Alb, proteínas totais (PT, triiodotironina (T3 e tiroxina (T4 de 16 ovelhas Santa Inês, 16 Texel e 15 Ile de France. A FR não diferiu no T1 e T2 na Santa Inês e Ile de France, sendo maior na Texel no T2. FR aumentou na primavera, na Texel, seguida da Ile de France e pela Santa Inês e caiu no outono para Santa Inês e Ile de France. FR foi maior à tarde, na Texel, na Ile de France e na Santa Inês. Maior FC na Santa Inês e Texel no T1 e menor na Ile de France. FC na Santa Inês foi superior nas estações do ano, e na primavera maior para todas as raças. Maior Gl, PT, Alb e T3 na Santa Inês, e iguais para Texel e Ile de France. T3 maior na Santa Inês no inverno; na Texel maior no inverno e primavera, sem diferenças para Ile de France. Gl, T3 e T4 iguais no T1 e T2, e a PT e Alb maiores no T2.We evaluated the supplemental protein (12% crude protein (CP (T1 and 16% CP (T2 in rectal temperature (RT, respiratory rate (RR and heart rate (HR, glucose (Gl, albumin (Alb, total protein (TP, triiodothyronine (T3 and thyroxine (T4 in 16 Santa Ines, 16 Texel and 15 Ile de France ewes. The RR was not differing in T1 and T2 in Santa Ines and Ile de France, being higher in Texel in T2. FR increased in the spring, in the Texel, followed by Ile de France and Santa Ines, and decreased in fall in Santa Ines and Ile de France. RR was higher in the afternoon, in the Texel, in Ile de France and Santa Ines. Higher HR in Santa Ines and Texel in T1, and smaller in Ile de France. HR in Santa Ines was higher in the seasons, and spring higher for all breeds. Greater Gl, TP, Alb and T3 in Santa Ines, and equal for Texel and Ile de France. T3 higher for the Santa Ines in the winter; in Texel higher in winter and spring; no differences for Ile de France. Gl, T3 and T4 were similar

  6. Use of flunixin meglumine in Santa Inês ewes submitted to laparoscopic and transcervical insemination

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    Renato Travassos Beltrame

    2014-10-01

    Full Text Available The objective of this work was to evaluate the use of flunixim meglumine in Santa Ines ewes submitted to artificial insemination (AI. Forty-four Santa Inês ewes were synchronized and inseminated at fixed times, by the transcervical or laparoscopic route, between 52 and 58 hours after sponge removal. The ewes were split into two treatment groups, to receive intramuscular injections of 2 mL of saline (control treatment or 2.2 mg/kg flunixin meglumine (FM treatment, twice a day between days 9 and 19 after AI. The pregnancy diagnosis was performed by ultrasound 30 days after the AI. The chi-square test was used to compare the pregnancy rate between the control and flunixin meglumine treatment and between type of insemination, while the t-test, at 5% probability was used to compare the average weight and body condition, using the SAS statistical software. Flunixin meglumine was not effect in increasing the pregnancy rate in Santa Ines ewes undergoing laparoscopic and transcervical insemination.

  7. Ovariectomy by laparotomy, a video-assisted approach or a complete laparoscopic technique in Santa Ines sheep

    OpenAIRE

    Teixeira, P. P. M; Padilha, L. C.; Motheo,T.F.; M.A.M. Silva; Oliveira, M.e.f. [UNESP; Silva, A. S. L. DA; Barros,F.F.P.C; Coutinho, L. N. [UNESP; F.N. Flores; Lopes,M.C.S.; Rodrigues, L. F. S.; W.R.R. Vicente

    2011-01-01

    The aim of the study was to compare the use of open ovariectomy, to the video-assisted laparoscopic approach or total laparoscopic ovariectomy in Santa Ines ewes. Surgical time and body weight gain/loss were recorded and post-surgical pain assessed using a behavioral scale. Laparotomy involved a longer surgical time (75 +/- 29.5 min), than the video-assisted (37.5 +/- 13.04 min; p < 0.05) or total laparoscopic approach (27.5 +/- 2.89; p < 0.01). Behavioral pain recorded score was higher for t...

  8. Use of reduced doses of eCG applied by different routes in the TAI program in Santa Ines sheep

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    Karla Dias Antunes-Melo

    2015-06-01

    Full Text Available The aims of this study were to improve the cost-benefit ratio of the application of artificial insemination in fixed time (TAI by the transcervical route in sheep, to test the dosage reduction and the use of the vulvar submucosa (VSM route as an alternative for the application of equine chorionic gonadotropin (eCG on the efficiency of the synchronization protocol and fertility to artificial insemination (AI and to measure the level of cortisol in ewes as a result the application of this biotechnique. Blood samples were collected before AI, immediately after AI and seven days after AI. Six groups of twenty animals were used, and each group received doses of 200, 300 and 400 IU of eCG by the intramuscular route (IM and VSM. Estrus was detected, and 48 hours later, the inseminations were performed by the transcervical route. Among the 120 treated ewes, 87.5% came in estrus. The percentage of the intrauterine deposition of semen was 88.3%. The pregnancy rate ranged from 20 to 70% between treatments, with an average of 46.66%. The VSM route was viable for the application of eCG in doses of 300 and 400 IU. The reduction in the eCG dose to 200 IU by the IM route reduces costs while maintaining the efficiency of estrus synchronization protocols and TAI with frozen semen in Santa Ines ewes. The average levels of cortisol were significant, at 1.15, 2.86 and 0.52 ?g/dL according to the three collections, being higher after the animal was off the easel at the end of AI. The procedures for performing the transcervical AI technique indicate that stress in the animals produces satisfactory fertility results and a low cost in multiparous ewes of the Santa Ines breed.

  9. Random regression models for the estimation of genetic and environmental covariance functions for growth traits in Santa Ines sheep.

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    Sarmento, J L R; Torres, R A; Sousa, W H; Lôbo, R N B; Albuquerque, L G; Lopes, P S; Santos, N P S; Bignard, A B

    2016-06-20

    Polynomial functions of different orders were used to model random effects associated with weight of Santa Ines sheep from birth to 196 days. Fixed effects included in the models were contemporary groups, age of ewe at lambing, and fourth-order Legendre polynomials for age to represent the average growth curve. In the random part, functions of different orders were included to model variances associated with direct additive and maternal genetic effects and with permanent environmental effects of the animal and mother. Residual variance was fitted by a sixth-order ordinary polynomial for age. The higher the order of the functions, the better the model fit the data. According to the Akaike information criterion and likelihood ratio test, a continuous function of order, five, five, seven, and three for direct additive genetic, maternal genetic, animal permanent environmental, and maternal permanent environmental effects (k = 5573), respectively, was sufficient to model changes in (co)variances with age. However, a more parsimonious model of order three, three, five, and three (k = 3353) was suggested based on Schwarz's Bayesian information criterion for the same effects. Since it was a more flexible model, model k = 5573 provided inconsistent genetic parameter estimates when compared to the biologically expected result. Predicted breeding values obtained with models k = 3353 and k = 5573 differed, especially at young ages. Model k = 3353 adequately fit changes in variances and covariances with time, and may be used to describe changes in variances with age in the Santa Ines sheep studied.

  10. Does supplemental LH changes rate and time to ovulation and embryo yield in Santa Ines ewes treated for superovulation with FSH plus eCG? Suplementação com LH modifica a taxa e momento da ovulação e a produção de embriões em ovelhas Santa Inês superovuladas com FSH e eCG?

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    Maria Emilia Franco Oliveira

    2012-06-01

    Full Text Available The objective was to evaluate if supplemental LH given at the end of FSH treatment would synchronize the time of ovulation and increase the ovulation rate and embryo yield in Santa Ines ewes. Twenty superovulatory (SOV programs were accomplished in cross-over design (60d interval. On D0, a CIDR device was inserted, and the device was replaced with a new one 7 days later, when 37.5µg of d-cloprostenol was administered. On D12, we started the SOV treatment, administering 256mg of pFSH 8 times, 12h apart. On D14, the CIDR was removed, and 200IU of eCG and 37.5µg of d-cloprostenol were administered. On D15, the ewes were allocated into one of two groups, a Control group (n=10 that received no supplemental LH and a LH group (n=10 treated with 7.5mg of LH 24h after CIDR removal. Artificial inseminations (AI were performed 42 and 48h after CIDR removal. The ovarian structures were evaluated by laparoscopy immediately before each AI and 5 days later (D21 when the embryos were collected. The LH ewes ovulated more frequently (P=0.05 before 42h than between 42 and 48h. Treatment with LH tended to increase the frequency of CL and to decrease the anovulatory follicles (P=0.08. The supplemental LH increased the frequency of ewes with a high SOV response (≥11 CL; P=0.05. In conclusion, supplemental LH increased the frequency of ewes with high SOV response and ovulating prior to 42h, however, there was no synchrony between ovulations. The supplemental LH also decreased the frequency of anovulatory follicles, although the ovulation rate and embryo yield were unaffected.O objetivo deste trabalho foi avaliar se a suplementação com LH ao final do tratamento gonadotrófico sincroniza o tempo das ovulações e incrementa a taxa de ovulação e produção de embriões em ovelhas Santa Inês. Vinte programas de superovulação (SOV foram realizados em delineamento cross-over (intervalo de 60 dias. No D0, um CIDR foi inserido, sendo trocado por um novo sete dias

  11. HEMATOLOGICAL PROFILE OF SANTA INÊS EWES SUPPLEMENTED ON PASTURE AT THE LAST THIRD OF PREGNANCY AND POSTPARTUM

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    Leilson Rocha Bezerra

    2015-07-01

    Full Text Available The purpose of this study was to evaluate the influence of concentrate supplementation level on hematological profile of Santa Ines ewes, at the last third of pregnancy and postpartum, and of their lambs. We used eleven ewes at the last 75 days of pregnancy and the first 75 days of lactation and eight lambs born from these ewes, allotted in a completely randomized design and split-plot arrangement in time. Blood samples were collected every fourteen days. Neither the erythrocyte nor the leukocyte profile was affected by the different levels of supplementation (P>0.05 and the blood components evaluated were within the reference range for adult sheep. The animal category affected (P0.05. For the lymphocyte count, the values found in lambs (2858.8 /µL were similar to those in pregnant ewes (2,982.0/µL; lactating ewes (4119.8/µL showed the highest values. Concentrate supplementation (0.5% BW at pre and postpartum does not alter the erythrocyte and leukocyte profile of Santa Inês sheep, with the largest differences between the two sheep categories and lambs.

  12. Effect of pre and post-slaughter processes on meat characteristics of Santa Ines ewes discarded due to age Efeito de processos de pré e pós-abate sobre características da carne de ovelhas da raça Santa Inês, descartadas por idade

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    Luiz Eduardo dos Santos

    2012-09-01

    Full Text Available The effects of body condition recovery (BC, carcass electrical stimulation (ES, aging time (AT 7 - 14 days, and calcium chloride injection on the meat characteristics of Santa Inês ewes (±5 years old slaughtered immediately after weaning or after the body condition recovery period were studied. The carcass temperature, pH, shear force (SF, cooking loss (CL, meat color (L*, a*, b*, and meat tenderness were evaluated. A completely randomized design in a 2 × 2 × 2 × 3 (BC × ES × CaCl2 × AT factorial arrangement was used, and the sensory tenderness data were analyzed using the table of Minimum Number of Correct Answers for the Duo-Trio test. The body condition recovery reduces the shear force in 8%, increasing their tenderness. Electrical stimulation reduced the shear force (24% and did not change the other parameters. The aging time (7 or 14 days decreased the shear force (18-26%, effect that was enhanced by electrical stimulation, and it darkened the meat reducing lightness (L* and increasing yellowness (b*. The treatment with CaCl2 was the most effective in tenderizing meat by reducing the shear force ( 35%; increasing the cooking loss (4.5%; and increasing L* and b* lightening the meat. The sensory evaluation of tenderness corroborates the findings of the experimental evaluation regarding the effect of the treatment with CaCl2 on the meat quality improvement. It was concluded that the treatments improve meat characteristics achieving better results when applied together.Estudaram-se os efeitos da recuperação da condição corporal (CC, da estimulação elétrica (EE, da maturação (M 7-14 dias e da infusão de CaCl2 sobre as características da carne de ovelhas Santa Inês (cerca de 5 anos de idade, abatidas ao desmame ou após o período de recuperação pós-desmame. Avaliaram-se a temperatura e o pH de carcaça, e a força de cisalhamento (FC; a perda por cocção (PC; a cor (L*, a* e b*, e a maciez da carne. Utilizou

  13. Analysis of growth curve in Santa Ines females sheep

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    Elisa Junqueira Oliveira

    2013-12-01

    Full Text Available In a sheep production system, the growth-related characteristics have direct relationship to both, quantity and quality of meat. The objective of this study was to evaluate the application of non-linear models to report the growth curve of Santa Inês sheep. Weights of 140 females, born from2010 to 2012, from a single herd at Cravinhos- SP were used. The weights were measured from birth to about one year of age and the ages were grouped together in biweekly classes. The average weight observed at birth was of 3.77±0.92 kg. The non-linear models utilized in the data adjustment were the Brody, Gompertz, Logistic and Von Bertalanffy models, adjusted by the Gauss-Newton method by means of NLIN procedure, available in SAS software. The parameters which compose the functions, Wt (kg is the weight in time t (days; A (kg is the asymptotic weight when age tends to infinity; b is an integration constant, related to the initial weights of the animals and not well defined biological interpretation, and k is the maturity rate. The average estimates for A and k, are the most important from an zootechnical parameters point of view, mainly because heavier females tend to create faster growing sheep. All the models evaluated reached convergence. The quality of the models adjustment was done by error mean square (EMS means. From the EMS results , the Gompertz model showed the best adjustment, which indicates increased association between the observed and estimated weights, in spite of the EMS values being quite close in all models, pointing out that all were adequate to report the growth curve from birth to one year of age in females of Santa Inês breed.

  14. Meat quality of castrated and non-castrated Santa Ines lambs subjected to food restriction

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    Dayanne Lima de Sousa

    2016-06-01

    Full Text Available This study aimed to evaluate the quality of meat of castrated and non-castrated Santa Ines lambs submitted to food restriction. Were used 30 lambs, 15 castrated and 15 non-castrated, about two months of age and average initial body weight of 13.00 ± 1.49 kg. The lambs were distributed in a completely randomized design in a factorial arrangement 3 x 2 (restriction level x sex class, according to the amount of food provided. The duration of the experiment was determined by the time required for the animals in the one of the groups achieved 28 kg of body weight. There was interaction between food restriction levels and sex class to the variables intensity of yellow color and pH in the longissimus lumborum muscle and the shear force in the semimembranosus muscle. In non-castrated animals, the intensity of yellow color was higher in the longissimus lumborum muscle at the level of 30% of food restriction. There was no significant interaction between food restriction levels and sex class for the quality aspects related to color saturation, color tone, luminosity, red intensity, water holding capacity and cooking losses in longissimus lumborum and semimembranosus muscles. Although food restriction and sex class have influenced the variables related to the quality of meat of the animals evaluated, the mean values are considered acceptable by the literature. The feeding restriction levels and sex class influence some important features of quality of Santa Ines lamb meat.

  15. Body composition and energy and protein nutritional requirements for weight gain in Santa Ines crossbred sheep.

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    Cutrim, Darley Oliveira; Alves, Kaliandra Souza; dos Santos, Rozilda da Conceição; da Mata, Vanessa Jaqueline Veloso; Oliveira, Luis Rennan Sampaio; Gomes, Daiany Íris; Mezzomo, Rafael

    2016-03-01

    This study was conducted to evaluate the body composition and net energy and protein requirements for weight gain in Santa Ines crossbred sheep. Thirty woolless, 4-month-old, castrated male sheep with an initial body weight (BW) of 19.77 ± 1.99 kg were used. Six animals (reference group) were slaughtered after the adaptation period to estimate empty body weight (EBW) and initial body composition. The remaining 24 animals were randomly distributed among four treatments (experimental diets) and slaughtered when they reached 30.24 ± 0.78 kg BW. The body composition ranged from 162.88 to 160.4 g protein/kg EBW, from 59.49 to 164.23 g fat/kg EBW and from 1.54 to 2.46 Mcal energy/kg EBW for animals ranging between 20 and 30 kg BW. The net energy requirement for Santa Ines crossbred sheep linearly increased when BW increased from 20 to 30 kg. Within that same weight range, the net protein requirement for weight gain in sheep was constant, ranging from 12.61 to 12.42 g/day to 100 g daily weight gain.

  16. Ingestive Behavior and Nitrogen Balance of Confined Santa Ines Lambs Fed Diets Containing Soybean Hulls

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    Bastos, Milena Patrícia Viana; de Carvalho, Gleidson Giordano Pinto; Pires, Aureliano José Vieira; Silva, Robério Rodrigues; Filho, Antônio Eustáquio; dos Santos, Edileusa de Jesus; Chagas, Daiane Maria Trindade; Barroso, Daniele Soares; Filho, George Abreu

    2014-01-01

    The objective of this study was to assess the effect of substituting corn with soybean hulls on the ingestive behavior and nitrogen balance of Santa Ines lambs. A total of 25 lambs with an initial body weight of 20±2 kg at approximately six months of age, sheltered individually in stalls (1.10 m×1.0 m), considering an entirely casual experimental delineation. Soybean hulls were substituted for corn at 0, 250, 500, 750, and 1,000 g/kg of dry matter (DM). The time spent feeding, ruminating, masticating, and resting was not affected by the substitution of corn with soybean hulls. In fact, the feeding efficiency in g DM/h and the rumination efficiency in g DM/bolus increased linearly with soybean hull substitution in the feed. Although the nitrogen balance was not altered by the use of soybean hulls as a substitute for corn in the diets of Santa Ines lambs, the N ingested and N digested expressed in g/d, N retained as a percentage of that ingested, and N retained as a percentage of that digested displayed quadratic behavior. In conclusion, corn can be substituted with soybean hulls up to 1,000 g/kg of dry matter in the concentrate, without changing the ingestive behavior and nitrogen balance. PMID:25049922

  17. Evaluation of carcass and muscle traits in Santa Ines female lambs finished with different agricultural products

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    A.M. Menezes

    Full Text Available ABSTRACT The aim of this study was to evaluate the effect of different agricultural products on quantitative aspects of carcass, body constituents, cooking loss, shear force and colorimetry of the Longissimus lumborum and Triceps brachii muscles in Santa Ines lambs. 24 Santa Ines female lambs received one of four diets which were isoproteic and isoenergetic with fixed levels of forage (60% and concentrate (40% of corn and soybean meal during 45 days. The forages per diet differed: coast-cross hay (HAY, cassava hay (CASS, dehydrated by-product of pea crop (PEA and sugarcane (SC. The average weight of the lambs at the beginning of the experiment was 26.35kg. Animals were slaughtered in a federally certified abattoir. Initial and final pH, cooking losses, color using the CIELAB system, shear force and the quantity of sarcomeres per 100μm were measured. Hot carcass, cold and half carcass weights were affected by treatments (P<0.05. The sarcomere length of Triceps brachii muscle 24 hours after slaughter differed between diets and coast-cross hay had the lowest value. The sarcomere length differed significantly between diets and the dehydrated by-product of pea crop had the lowest number of sarcomeres immediately after slaughter compared to other diets. There was no influence of diet on colorimetry, cooking loss and shear force. The decrease in pH followed the development of the process of rigor mortis in the Longissimus lumborum and Triceps brachii muscles in the first hour and up to 24 hours after slaughter. Diets did not alter the pH, water holding capacity, colorimetry or shear force. The pea by-product and sugarcane can replace traditional sources of fodder without depreciation of meat characteristics.

  18. Carcass and meat traits of Morada Nova, Santa Ines and ½ Ile de France ½ Texel lambs finished in feedlot

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    Juliano Issakowicz

    2014-03-01

    Full Text Available The aim of this study was to evaluate the carcass and meat traits of Morada Nova, Santa Ines and ½ Ile de France ½ Texel lambs finished in feedlot. Weight and proportion of meatcuts, measures of carcass size and color, tenderness, cooking loss and ultimate pH of meat from 10 Morada Nova, 6 Santa Ines and 10 ½ Ile de France ½ Texel were evaluated. The lambs were finished in collective pens, fed ad libitum with 50% corn silage and 50% concentrate and slaughtered at about six months old. Analysis of variance was performed by the procedure PROC GLM of SAS (SAS Inst., Inc., Cary, NC and means were compared by Tukey test at 5% significance. The Morada Nova lambs had values of 14.1 kg, 13.9 kg, 0.240 kg/cm, 56.2 cm and 35.8 cm for hot and cold carcass weight, compactness index, hip and leg circumference respectively and these values were lower (P <0.05 to values observed in Santa Ines (19.4 kg, 18.8 kg, 0.283 cm/kg, 64.6 cm and 40.0 cm and in ½ Ile de France ½ Texel (18.6 kg, 18.2 kg, 0.305 cm/kg; 65.4 cm and 41.6 cm lambs. The hot and cold carcass yield did not differ (P> 0.05 among genetic groups. The scores for conformation and fat cover were higher (P <0.05 in ½ Ile de France ½ Texel lambs (2.4 and 3.0 and the carcass length was greater in Santa Ines lambs (66.3 cm. The ½ Ile de France ½ Texel lambs had smaller (P<0.05 proportion of neck and greater of leg (9.10% and 33.1% compared to Morada Nova lambs (10.3% and 30.4% and Santa Inês (10.9% and 31.6%. The weight of shoulder, leg, rack, ribs and flank was lower (P<0.05 in Morada Nova (1.306, 2.127 kg, 0.999 kg, 0.775 kg and 0.433 kg respectively compared to Santa Inês (1.820 kg, 2.972 kg, 1.355 kg, 0.959 and 0.509 kg and ½ Ile de France ½ Texel (1.791 kg, 3.007 kg, 1.212 kg, 1.016 kg and 0.563 kg. The neck was heavier in Santa Ines (1.038 kg which differed (P <0.05 from the other genetic groups (0.725 kg for Morada Nova and 0.830 kg for ½ Ile de France x ½ Texel lambs. The ½ Ile de

  19. Estudo da curva de crescimento de ovinos Santa Inês Analysis of the growth curve of Santa Ines sheep

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    José Lindenberg Rocha Sarmento

    2006-04-01

    Full Text Available Utilizaram-se 7.271 registros de pesos do nascimento aos 196 dias de idade de 952 crias de ovinos Santa Inês, controlados de 1983 a 2000, com os objetivos de verificar, entre os modelos Brody, Von Bertalanffy, Logístico, Gompertz e Richards, aquele que melhor descreve a curva média de crescimento e avaliar a influência de efeitos de ambiente sobre os parâmetros estimados. Os parâmetros foram estimados usando-se o procedimento NLIN do SAS. Para verificar se uma única curva seria adequada para descrever o crescimento de machos e fêmeas, nascidos de partos simples ou duplo, aplicou-se um teste de igualdade de parâmetros de modelos não-lineares. Os cinco modelos ajustaram bem os dados de crescimento, entretanto, maior variação dos resíduos foi verificada para os modelos Brody e Logístico. Com base nos desvios médios absolutos dos resíduos, constatou-se que o modelo Gompertz apresentou ajuste médio ligeiramente superior aos modelos Von Bertalanffy e Richards. Machos e fêmeas, nascidos de partos simples e duplo, apresentaram padrões de crescimento divergentes. Os efeitos de grupos contemporâneos, tipo de nascimento e sexo foram importantes fontes de variação para os parâmetros A e K. A correlação estimada entre os parâmetros A e K foi negativa. Melhorias no manejo alimentar devem ser incrementadas, principalmente quanto ao armazenamento de forragem, visando diminuir os efeitos indiretos do clima, o que poderá refletir em menor variação na forma da curva de crescimento.Records of 7,271 weights of 952 lambs measured from birth up to 196 days of age between 1983 and 2000, available from the Agricultural Research Corporation of Paraiba database, were used to model the average growth curve of Santa Ines sheep. The influence of environmental effects on the estimated parameters of the Brody, Von Bertalanffy, Logistic, Gompertz and Richards functions was evaluated using the NLIN procedure of SAS. The growth curve was well fitted

  20. Effects of birth type and family on the variation of carcass and meat traits in Santa Ines sheep.

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    Jucá, Adriana de Farias; Faveri, Juliana Cantos; Melo Filho, Geraldo Magalhães; Ribeiro Filho, Antônio de Lisboa; Azevedo, Hymerson Costa; Muniz, Evandro Neves; Pedrosa, Victor Breno; Pinto, Luís Fernando Batista

    2016-02-01

    This study aimed to evaluate the effects of birth type and family on quantitative and qualitative meat traits in Santa Ines lambs and to do a descriptive study of variation inside of breed. A total of 50 carcass and meat traits were evaluated in up to 101 lambs slaughtered at 424 days of age. Random effect of family, the fixed effect of birth type (single or double) and year, and the covariates of dam's weight at weaning and age (in days) at slaughter were inserted in the model. This study shows that some carcass and meat traits in Santa Ines raised on pasture has large variability, specially for meat cut yields, several carcass non-components yields, and rib eye area, subcutaneous fat thickness, shear force, cooking losses, and b* color parameter. The birth type effect influenced (P < 0.05) rump width; reticulum, leg, heart and kidney yields; and the carcass pH at 24 h after slaughter. The family effect was significant (P < 0.05) for cold carcass weight; hot, cold and true carcass yields; external carcass and leg lengths; perimeter and width of the rump; kidney, liver and tail yields; and carcass pH at slaughter.

  1. Impact of Brazilian red propolis extract on blood metabolites, milk production, and lamb performance of Santa Inês ewes.

    Science.gov (United States)

    Morsy, Amr S; Soltan, Yosra A; Sallam, Sobhy M A; Alencar, Severino M; Abdalla, Adibe L

    2016-06-01

    Twenty Santa Inês ewes used to evaluate effects of oral administration of Brazilian red propolis extract on blood metabolites, milk production, and lamb performance were randomly grouped (n = 10 ewes/group) to control without propolis administration and propolis treated (3 g red propolis extract/ewe/day) 21 days before expected lambing date. Blood samples were collected weekly, and daily milk yield was recorded twice weekly until 7 weeks postpartum. Propolis administration increased (P milk, fat, protein, and lactose. Propolis supplementation increased (P milk conversion ratio but had no effect on lamb birth and weaning weights. The prepartum administration of propolis extract supported positively the transition of ewes from pregnancy to lactation with health benefits achieved for both of ewes and lambs performances.

  2. Male effect associated with suckling interruption on the reproductive performance of Santa Inês ewes

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    Eduardo Luiz Cavalcante Caldas

    2015-07-01

    Full Text Available This study aimed to evaluate the effect of temporary suckling interruption associated with the male effect on reproductive performance of pluriparous Santa Inês ewes. The females were kept apart from the males for 60 days and then randomly distributed into three treatments associated with the male effect (DT0, DT24 and DT48; in DT0, there was no suckling interruption; in DT24, suckling was interrupted for 24 hours, and in DT48, sucking was interrupted for 48 hours. Estrous distribution was observed within 31 (DT0, 27 (DT24 and 38 (DT48 days of the breeding season. Estrous synchronization up to the 5th day of the mating season was observed in 15% (DT0, 30% (DT24 and 25% (DT48 of the females, with no difference among treatments. Estrous percentages were 90% (DT0, 100% (DT24 and 100% (DT48, with no difference among treatments. Pregnancy rates were 38.4% (DT0, 60.0% (DT24 and 45.0% (DT48 with no difference among treatments. Prolificacy was 1.43 (DT0, 1.17 (DT24 and 1.22 (DT48 and did not differ between treatments. In conclusion, temporary suckling interruption associated with the male effect is efficient to induce estrous but not to synchronize estrous or increase the pregnancy rates and prolificacy of Santa Inês ewes during a 45-day breeding season.

  3. Efeito da restrição alimentar durante o final da gestação sobre o peso ao nascer de cordeiros Santa Inês Effects of maternal undernutrition during final pregnancy on weight birth of Santa Ines lambs

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    Luciana Castro Geraseev

    2006-04-01

    Full Text Available O experimento foi conduzido no setor de Ovinocultura da Universidade Federal de Lavras, com o objetivo de avaliar o peso ao nascer de cordeiros da raça Santa Inês, machos e fêmeas, nascidos de ovelhas submetidas ou não a uma restrição alimentar durante o terço final da gestação. Para tanto, foram utilizadas 44 ovelhas Santa Inês gestando gêmeos, as quais com 100 dias de gestação, foram confinadas e divididas em dois grupos: um grupo recebeu alimentação à vontade para satisfazer suas necessidades energéticas, e o segundo grupo recebeu alimentação restrita para satisfazer 60% das suas necessidades energéticas. O cálculo das necessidades energéticas foi baseado nas recomendações do ARC (1980, levando-se em consideração o peso da ovelha, o tempo de gestação e o número de fetos que cada ovelha estava gestando. Com relação as ovelhas, foram avaliados o peso corporal no início do experimento e logo após a parição, a duração da gestação e a massa biológica produzida. Com relação aos cordeiros, foram avaliados o peso ao nascer dos mesmos, sendo que para tanto estes animais foram divididos de acordo com o sexo (machos e fêmeas. O peso ao nascer dos cordeiros machos e fêmeas foi afetado pela restrição pré-natal, sendo que a média do peso ao nascer dos cordeiros machos sem restrição foi 4,162 kg e com restrição 2,893 kg; e o peso ao nascer das cordeiras fêmeas sem restrição foi 3,474 kg e com restrição 2,855 kg. A grande redução observada neste trabalho no peso ao nascer dos cordeiros machos (30,5% e fêmeas (17,8% revela a importância da adoção de um nível nutricional adequado para as ovelhas gestantes, principalmente durante o terço final da gestação.An experiment was conducted in the Sheep Production Sector of the Animal Science Department at the Federal University of Lavras, Lavras MG to evaluate weight birth of Santa Ines lambs, males and females from ewes submitted or not to feed

  4. Colour Doppler Ultrasonography as a Tool to Assess Luteal Function in Santa Inês Ewes.

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    Figueira, L M; Fonseca, J F; Arashiro, Ekn; Souza-Fabjan, Jmg; Ribeiro, Acs; Oba, E; Viana, Jhm; Brandão, F Z

    2015-08-01

    The aim of this study was to evaluate luteal dynamics in the Santa Inês ewes using colour Doppler (CD) ultrasonography. Oestrus was synchronized in nulliparous females (n = 18), and subsequently, they were only teased (n = 6) or teased and mated (n = 12). Blood samples were collected daily for plasma progesterone (P4 ) concentrations. Ultrasonographic images of corpora lutea (CL) in CD mode were obtained for further analysis in its largest diameter. The CD mode allowed an early sequential monitoring of CL that was visualized by the first time 0.77 ± 0.62 days after ovulation, with luteal area 29.68 ± 13.21 mm(2) . During the luteogenesis, a progressive increase was observed, followed by a plateau of luteal area, vascularization area and plasma concentrations of P4 reaching maximum values in D11 (124.0 ± 38.0 mm(2) , 52.78 ± 24.08 mm(2) and 11.23 ± 4.89 ng/ml, respectively). In the luteolysis, the plasma concentrations of P4 decreased sharply, whereas luteal and vascularization area gradually. The vascularization area was positively correlated with plasma concentrations of P4 during the luteogenesis (r = 0.22) and luteolysis (r = 0.48). The luteal dynamics of Santa Inês ewes showed patterns similar to those observed in other sheep breeds studied. The CD ultrasonography has the potential to be used as a tool to assess luteal function in sheep.

  5. Metabolic profile of santa inês ewes whith low body condition score during peripartum

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    Nayara Resende Nasciutti

    2012-02-01

    Full Text Available The objective of this study was to analyse the variations in the metabolic profile of protein, energy enzyme and mineral of Santa Inês ewes with low body condition score (BCS during peripartum. Blood samples were collected from 12 animals by jugular venipuncture to determine the serum biochemical profiles of protein, energy, mineral and enzyme metabolisms. Samples were collected on the following days: days 28, 21, 14, and 7 before lambing, at birth and, at days 2, 4, 7, 14, 21, and 28 postpartum (dpp. The samples were centrifuged and the serum analysed by Automated-Analyser. There was no alteration of the BCS during the 28 dpp, between 0.6 and 2.1 ± 2.4 ± 0.5, and was considered, as lean. The values of the total serum protein, globulin, albumin, and albumin/globulin ratio were reduced effective from the period before birth until 28dpp. The values of beta-hydroxybutyrate, calcium, phosphorus and magnesium remained below those of reference values. The concentrations of alanin aminotransferase (ALT were decreased particularly during the weeks before delivery. It was concluded that Santa Inês sheep with low body condition score demonstrated a reduction in the metabolism of proteins, energy, mineral and enzyme during peripartum.

  6. The effects of palm kernel cake based diet on spermatogenesis in Malin x Santa-Ines rams.

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    Yaakub, H; Masnindah, M; Shanthi, G; Sukardi, S; Alimon, A R

    2009-10-01

    Testes from nine male Malin x Santa-Ines rams with an average body weight of 43.1+/-3.53 kg, were used to study the effects of palm kernel cake (PKC) based diet on spermatogenic cells and to assess copper (Cu) levels in liver, testis and plasma in sheep. Animals were divided into three groups and randomly assigned three dietary treatments using restricted randomization of body weight in completely randomized design. The dietary treatments were 60% palm kernel cake plus 40% oil palm frond (PKC), 60% palm kernel cake plus 40% oil palm frond supplemented with 23 mg/kg dry matter of molybdenum as ammonium molybdate [(NH(4))(6)Mo(7)O(24).4H(2)O] and 600 mg/kg dry matter of sulphate as sodium sulphate [Na(2)SO(4)] (PKC-MS) and 60% concentrate of corn-soybean mix+40% oil palm frond (Control), the concentrate was mixed in a ratio of 79% corn, 20% soybean meal and 1% standard mineral mix. The results obtained showed that the number of spermatogonia, spermatocytes, spermatids and Leydig cells were not significantly different among the three treatment groups. However, spermatozoa, Sertoli cells and degenerated cells showed significant changes, which, may be probably due to the Cu content in PKC. Liver and testis Cu levels in the rams under PKC diet was found to be significantly higher (P<0.05) than rams in Control and PKC-MS diets. Plasma Cu levels showed a significant increase (P<0.05) at the end of the experiment as compared to at the beginning of the experiment for PKC and Control. In conclusion, spermatogenesis is normal in rams fed the diet without PKC and PKC supplemented with Mo and S. However spermatogenesis was altered in the PKC based diet probably due to the toxic effects of Cu and the significant changes in organs and plasma. Thus, Mo and S play a major role in reducing the accumulation of Cu in organs.

  7. Qualidade da carne de cordeiros Santa Inês terminados com diferentes dietas Quality of Santa Ines lamb meat terminated with different diets

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    Marta Suely Madruga

    2005-02-01

    Full Text Available Foram avaliados os aspectos qualitativos da carne de cordeiros Santa Inês submetidos, na fase de terminação, a sistemas de alimentação diferenciados. Foram analisadas 24 pernas de cordeiros não-castrados, com idade de abate entre seis e dez meses, distribuídos eqüitativamente segundo as dietas recebidas: T1 = feno de capim-d'água + concentrado, T2 = feno de restolho de abacaxi + concentrado, T3 = palma + mistura, T4 = silagem de milho + concentrado. A utilização de quatro tipos de alimentos volumosos exerceu influência significativa sobre os teores de composição centesimal, cálcio, fósforo, colesterol, fosfolipídios, ácidos graxos saturados e poliinsaturados e nos parâmetros sensoriais da carne de ovinos Santa Inês. Os cordeiros alimentados com volumosos energéticos (T1, T2 e T4 apresentaram carnes com maiores concentrações lipídicas em (6,93; 8,09 e 8,38%, respectivamente, melhor qualidade sensorial e maiores percentuais de ácidos graxos monoinsaturados (C18:1, C16:1, com médias de 41,38; 46,40; 43,15 e 3,44; 3,34; e 2,76%, respectivamente. O uso de palma forrageira (T3 na alimentação dos cordeiros resultou em uma carne com teores de umidade, proteínas, fósforo, cálcio, colesterol e ácidos graxos saturados significativamente maiores em relação aos demais volumosos (T1, T2 e T4, porém com qualidade sensorial inferior.This study had the objective of evaluating the qualitative aspects of lamb meat from Santa Ines breed when submitted in the termination phase to different feeding systems. Twenty four legs from entire lambs with slaughter age from six to ten months were equally distributed among four different diets: T1 = capim-d'água hay + concentrate, T2 = pineapple hay + concentrate, T3 = forage palm + mixture, T4 = maize ensilage hay + concentrate. The utilization of four different forager feeds resulted in significant difference among the percentages of centesimal composition, calcium, phosphorus, cholesterol

  8. Zona de conforto térmico de ovinos da raça Santa Inês com base nas respostas fisiológicas Thermal comfort zone of Santa Ines sheep based on physiological responses

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    Antônio Eustáquio Filho

    2011-08-01

    Full Text Available Objetivou-se estabelecer a zona de conforto térmico para ovinos da raça Santa Inês por meio da comparação das respostas fisiológicas em diferentes opções de temperatura em câmara bioclimática. O experimento teve duração de 71 dias e foi conduzido utilizando-se sete borregas da raça Santa Inês por tratamento. Os tratamentos foram as faixas de temperatura de 10, 15, 20, 25, 30, 35 e 40°C, com três repetições (dias de exposição e cinco dias de intervalo. O delineamento experimental utilizado foi o inteiramente casualizado. Os dados meteorológicos coletados foram temperatura de bulbo seco, temperatura de bulbo úmido e temperatura de globo negro e os fisiológicos, frequência respiratória, frequência cardíaca, temperatura retal, temperatura timpânica, taxa de sudação e pressão arterial. Os mecanismos fisiológicos de dissipação de calor mostraram-se eficientes em manter a homeotermia dos animais em todas as temperaturas avaliadas. A temperatura de 25°C pode ser considerada a zona de conforto térmico para borregas da raça Santa Inês em ambiente com umidade relativa de 65%.The objective was to establish the thermal comfort zone for Santa Ines sheep by comparing the physiological responses at different options of temperatures in bioclimatic chamber. The experiment lasted 71 days and was conducted with the use of seven Santa Ines lambs per treatment. The treatments were temperature ranges of 10, 15, 20, 25, 30, 35 and 40ºC with tree replicates (exposure days and a five-day interval. The experimental design was completely randomized. Meteorological data collected were: dry bulb temperature; wet bulb temperature and black globe temperature. Physiological data analyzed were: respiratory rate, heart rate, rectal temperature, tympanic temperature, sweating rate and blood pressure. The physiological mechanisms of heat dissipation are shown to be effective in maintaining the homeothermy of the animals studied at all

  9. Productive traits of Santa Inês and Morada Nova ewes mated with Dorper rams in Southeastern Brazil

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    André Torres Geraldo

    2013-12-01

    Full Text Available Naturalized Brazilian hair breeds are adapted to tropical climate, however produce lambs for slaughter with lower performance and carcass traits. One way to increase productiveness comprises the use of adapted ewes crossed with specialized meat breeds, exploiting the complementarity between breeds and heterosis for sustainable lamb production. Dorper rams can be use to produce crossbred lambs with better performance traits. The aim of this study was to evaluate the weight at birth and at 30 days of Morada Nova lambs (MN and Santa Inês (SI straight breed or Dorper crossbred. The study was carried out at Instituto de Zootecnia, city of Nova Odessa, located in São Paulo State, Brazil. Forty-two adult Santa Inês (SI ewes with 51.8 ± 7.1 Kg of initial body weight, with 21 mated with SI rams and 21 mated with Dorper (DO rams and 38  Morada Nova (MN with 33.1 ± 4.98 with 19 mated with MN and  19 mated with DO rams were used. During pregnancy the ewes were reared on intensive grazing systems with rotational grazing on Aruana grass (Panicum maximum cv. Aruana, plus corn silage ad libitum and a concentrate mixture (400 g/day with 16% crude protein and 80% of total digestible nutrient (TDN on  final third of gestation. After lambing, the ewes were kept in collective pens and kept under the same diet used in late pregnancy. The weight at birth as well as at 30 day old were recorded and calculated the percentage of lamb weight in relation of ewe weights. Statistical analyses were performed using SPSS software version 12. Based on data is possible to observe that the SI X DO lambs had the highest birth weight followed by the straight breed SI and MN. At 30 day, the SI lambs had greater live weight than MN lambs. No difference was found for lamb´s weights in relation to ewe’s weight. We conclude that SI crossbred or straight breed lambs are heavier than MN ones.

  10. AVALIAÇÃO ULTRASSONOGRÁFICA DOS TESTÍCULOS E DAS GLÂNDULAS SEXUAIS ANEXAS DE CARNEIROS SANTA INÊS ULTRASONOGRAPHIC EVALUATION OF TESTICLES AND ANNEXES SEX GLANDS OF SANTA INES RAMS

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    Adriana de Farias Jucá

    2009-07-01

    Full Text Available No presente estudo, avaliaram-se 49 carneiros da raça Santa Inês por meio de exames andrológicos e de imagens ultrassonográficas dos testículos e das glândulas sexuais anexas, visando à utilização do ultrassom como recurso diagnóstico para avaliação morfofisiológica de reprodutores. Os animais foram divididos em três grupos: G1 com vinte animais de dezoito meses de idade, G2 com quinze animais de trinta meses e G3 com quatorze animais de quarenta e oito meses. Realizaram-se as seguintes mensurações: comprimento, largura, volume e forma testiculares e a circunferência escrotal. O sêmen foi colhido através de eletroejaculação e as avaliações realizadas segundo normas do CBRA (1998. Procedeu-se às análises ultrassonográficas antes e após a ejaculação, iniciando-se pelos testículos (estroma e mediastino. A calcificação testicular do tipo leve foi observada com maior frequência, independentemente, da idade. A ecotextura predominante das glândulas bulbouretrais e vesiculares foi a hipoecoica de baixa intensidade. Concluindo, a ultrassonografia mostrou-se eficiente para visualização e classificação do estroma e mediastino testiculares, assim como das glândulas sexuais anexas de carneiros Santa Inês.

    PALAVRAS-CHAVES: Carneiro, glândulas sexuais anexas, Santa Inês, testículos, ultra-sonografia. In the current study 49 rams of the Santa Ines breed were evaluated through andrologic examinations and ultrasonographic images of the testicles and annexes sexual glands, aiming the ultrasonography utilization as a diagnosis feature, for the morphophysiologic evaluation of future reproducers. The animals were divided into three groups G1 with 20 animals of 18 month-old, G2 with 15 animals of 30 month-old and G3 with 14 animals of 48 month-old. The following measurements were performed: length, width, volume and shape testicle, and also scrotal circumference. The semen was obtained through eletroejaculation

  11. Occurrence of caseous lymphadenitis in sheep breed Santa Ines with surface reactive lymph nodes at Uberlândia region, Minas Gerais

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    Vinícius de Morais Barbosa

    2012-02-01

    Full Text Available This work aimed to evaluate the occurrence of caseous lymphadenitis and tuberculosis in Santa Ines sheep, with the presence of reactive superficial lymph nodes on clinical examination, it was examined 650 adult animals, between one and four years of age from 11 farms in the region of Uberlândia, Minas Gerais, Brazil. Tuberculin cervical comparative test (CCT was performed, as well as microbiological culture and polymerase chain reaction technique (PCR for positive cultures and serum samples for Corynebacterium pseudotuberculosis identification. From the total of 650 sheep examined, 14.6% (96/650 had at least one presented swelling superficial lymph node, and the frequency was: pre-scapular reactive lymph nodes (41.9%, submandibular (38.1%, parotid (14 3% and pre-crural (5.7%. The microbiological culture punctured material showed growth of Corynebacterium pseudotuberculosis in 81.8% of the samples (18/22, Staphylococcus sp and Escherichia coli in 4.6% (1/22 and no growth in 13.6% (3/22. All 18 samples of the culture of C. pseudotuberculosis were positive by PCR and only (3/22 serum samples positive by PCR. The TCC made of 96 sheep, 93 negative tests and 3 inconclusive. It is concluded that in Santa Inês sheep with the presence of swelling in superficial lymph node, the incidence of caseous lymphadenitis was 81.8% (18/22 and 3.1% (3/96 of animals were inconclusive in the tuberculin cervical comparative test.

  12. Effect of multiple stress factors (thermal, nutritional and pregnancy type) on adaptive capability of native ewes under semi-arid environment.

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    Dias E Silva, Tairon Pannunzio; Costa Torreão, Jacira Neves da; Torreão Marques, Carlo Aldrovandi; de Araújo, Marcos Jácome; Bezerra, Leílson Rocha; Kumar Dhanasekaran, Dinesh; Sejian, Veerasamy

    2016-07-01

    This study was conducted to evaluate the effect of multiple stress factors (thermal, nutritional and pregnancy type) on two different native track breeds of ewes as reflected by their adaptive capability under semi-arid environment. The multiple stressor experiment was conducted in twenty-four ewes (12 Santa Inês and 12 Morada Nova ewes). Both heat stress and pregnancy stress was common to all four groups. However, the animals were divided into further two groups within each breed on the basis of nutrition regimen. According the groupings were: Group 1 (Six Santa Ines ewes; heat stress; nutrition at 0.5% of BW; single pregnancy); Group 2 (Six Santa Ines ewes; heat stress; nutrition at 1.5% BW; twin pregnancy); groups Group 3 (Six Morada Nova ewes; heat stress; nutrition at 0.5% of BW; single pregnancy); Group 4 (Six Morada Nova ewes; heat stress; nutrition at 1.5% BW; twin pregnancy). All the animals in the experiment were pregnant. Heat stress was induced by exposing all animals to summer heat stress in outside environment while the nutritional regimen followed was at 0.5% and 1.5% level of body weight (BW) respectively in each breed. The experiment was conducted in a completely randomized design with two breeds, two nutritional treatments and two pregnancy types, 10 repetitions for physiological parameters and six for blood parameters, with repeated measures over time. Physiological parameters (respiratory rate, pulse rate and rectal temperature) were measured with the animals at rest in the morning and afternoon, 0600-0700 and 1300-1400h, respectively, every seven days. Blood samples were collected every 14d for determination of serum glucose, triglycerides, cholesterol, urea and creatinine. We found interaction effect between breed and pregnancy type on respiratory rate and rectal temperature with greater values in Santa Inês ewes than Morada Nova ewes. However, there was no significant fixed effect of pregnancy type and supplementation level on physiological

  13. Effect of Brazilian red propolis administration on hematological, biochemical variables and parasitic response of Santa Inês ewes during and after flushing period.

    Science.gov (United States)

    Morsy, Amr S; Abdalla, Adibe L; Soltan, Yosra A; Sallam, Sobhy M A; El-Azrak, Kheir El-Din M; Louvandini, Helder; Alencar, Severino M

    2013-10-01

    Brazilian red propolis was administered orally to Santa Inês ewes, and evaluation was made of general health and hematological, biochemical, and parasitic responses during and after flushing. Thirty mature, nonlactating, nonpregnant Santa Inês ewes (40 ± 2 kg and 2.5 years old) were grazing tropical pasture (Brachiaria decumbens and Pennisetum purpureum) and, as flushing after synchronization, were supplemented with a concentrate-roughage mixture at a rate of 4 % body weight (BW). Ewes were divided according to BW and fecal egg count (FEC) into two groups (n = 15 each): control and propolis that received propolis ethanolic extract at rates of, respectively, 0 and 3 g/ewe/day. The treatments lasted 21 days until the end of flushing period. BW and body condition score (BCS) were recorded, and blood and fecal samples were taken weekly for 8 weeks. Mean values of BW and BCS were not (P > 0.05) affected by propolis administration. Propolis increased (P Propolis increased (P Propolis decreased (P Propolis administration had good impact on ewe health and may be a promising feed additive during critical periods such as flushing.

  14. Reproductive and productive performances of Santa Inês ewes submitted to breeding in different periods of the Amazonian humid tropical climate.

    Science.gov (United States)

    Soares, Felipe Nogueira; Oliveira, Maria Emilia Franco; Padilha-Nakaghi, Luciana Cristina; de Oliveira, Luís Guilherme; Feliciano, Marcus Antônio Rossi; de Oliveira, Felipe Brener Bezerra; Teixeira, Pedro Paulo Maia; Vicente, Wilter Ricardo Russiano; Faturi, Cristian; Rodrigues, Luiz Fernando de Souza

    2015-12-01

    The objective of this study was to evaluate the reproductive and productive performance of Santa Inês ewes bred at different times of the year in humid tropical climate. One hundred and forty-eight Santa Inês ewes were grouped according to the time of the year of their breeding season (i.e., mating period) (dry/wet, wet, wet/dry, and dry season). The service type was natural mating and the ewes and rams were kept together every night for 45 days. Reproductive efficiency was assessed by service, pregnancy, lambing, prolificacy, twinning, pregnancy loss, weaning, and lamb mortality rates. Ewes were weighed at the beginning and at the end of the breeding season and before and after parturition, and sequential weighing of the lambs was performed (at birth, 15, 30, 60, and 90 days). Reproductive efficiency index (number of lambs weaned/total of served ewes) and productive efficiency (kg of weaned lamb/kg of served or lambed ewes) were calculated. All ewes expressed estrus early in the breeding season; however, a higher percentage (53.5 and 7.1 % at 30 and 45 days, respectively) of ewes returned to estrus during the wet/dry period. The lower rates (13.9 %) of return to estrus at 30 days were during the wet season (P  0.05) effects of breeding seasons on the remaining reproductive rates. Ewes that lambed during the wet/dry transition period weighted less, before (40.5 ± 2.5 kg) and after (38.6 ± 1.6 kg) parturition, than those of other groups (P breeding season took place during the dry/wet period (P breeding seasons took place, allowing for four breeding seasons a year in the Amazon region. Variations between periods in return to estrus rates, weight of ewes close to parturition and lamb weight at weaning indicate that climate changes can also affect reproductive rates.

  15. Frequency of estrus in Santa Inês, Texel and Ile de France ewes in the northwest of Paraná State, Brazil

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    Gentil Vanini de Moraes

    2013-10-01

    Full Text Available The incidence of estrus in nulliparous Santa Inês (n = 16, Texel (n = 16 and Ile de France (n = 15 ewes fed two levels of crude protein (CP, 12 or 16% was monitored from July 2005 to December 2006, and seasonality in the Santa Inês breed in the south of Brazil was characterized. The solar radiation data were recorded daily, and samples of blood were collected biweekly for determination of the plasma concentration of progesterone in Santa Inês lambs at, on average, 11±1 months of age. The female Santa Inês lambs, in the experimental period, stayed among teaser rams with a powdered-dye-ink mixture placed on their chest to mark the females that accepted to be mounted. Santa Inês ewes did not manifest estrus in the first fortnight of November and in December 2005, nor in the last fortnight of December 2006. Estrus activity was not observed on any of the three breeds in October 2006. Breeds differed at the level of 12% CP. Santa Inês and Ile de France females did not differ as for the probability estrus manifestation and both presented higher probabilities then Texel. When the effect of 12 or 16% CP on each breed was evaluated separately, it was verified that levels of 12 or 16% of crude protein did not change the probability of estrus manifestation in any of the studied breeds. The concentration of plasma progesterone in Santa Inês ewes during the spring of 2005 and 2006 indicated that there is difference between 12% CP (0.68±1.32 ng/mL and 16% CP (1.28±1.99 ng/mL and between the years 2005 (0.39±0.78 ng/mL and 2006 (1.47±2.08 ng/mL, demonstrating the anestrous seasonality of Santa Inês in South Brazil.

  16. Influence of lactation stages and rain periods on subclinical mastitis in meat producing ewes

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    Luiz Francisco Zafalon

    Full Text Available ABSTRACT: Mastitis negatively influences the survival and weight gain of ovines for meat production. The purpose of this study was to investigate, in sheep for meat production, the occurrence of subclinical mastitis in ewes at the end of lactation and beginning of the consecutive lactation and to assess the composition and cellular characteristics of milk as a function of different rainfall indices. Mammary halves (821 of Santa Ines (479 and Morada Nova (342 ewes were examined. Milk samples were collected in two different moments of lactation: at weaning and postpartum of the consecutive lactation. Sample collection periods were called "dry" or "rainy" according to the rainfall index in the month immediately before the month of collection. The occurrence of subclinical mastitis at weaning in the Santa Ines and Morada Nova ewes were 16.4 and 12.6% in the dry period, and 17.7 and 23.5% in the rainy period, respectively. In the consecutive lactation period, the occurrences were 26.7 and 27.7% in the dry period and 41.8 and 39.1% in the rainy period, for the Santa Ines and Morada Nova ewes, respectively. Postpartum stage was critical for the occurrence of subclinical mastitis, as compared to that at the end of the previous lactation. Occurrence of the disease negatively influenced the SCC in the milk at the beginning of lactation and changed its composition, mainly in the rainiest periods, probably due to a difficulty in maintaining hygiene in the environment where the animals remained.

  17. Digestibilidade da dieta, parâmetros ruminais e desempenho de ovinos Santa Inês alimentados com polpa cítrica peletizada e resíduo úmido de cervejaria Diet digestibility, ruminal parameters and performance of Santa Ines sheep fed dried citrus pulp and wet brewer grain

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    Susana Gilaverte

    2011-03-01

    mixture of wet brewer grain and citrus pulp. In experiment 1, for evaluation of intake, apparent digestibility of nutrients and ruminal parameters, 12 Santa Ines ram lambs fitted with canulas in the rumen were assigned to a randomized complete block design with three diets and four replicates. In experiment two, for performance evaluation, 48 ewe lambs were confined and fed the same diets of experiment 1. Replacement of corn by dried citrus pulp did not affect intake or digestibility of nutrients in the diet. However, the inclusion of wet brewer grain reduced intake and apparent digestibility of nutrients, with exception of NDF. Apparent digestibility of NDF was similar among diets. Inclusion of wet brewer grain in the diet decreased ruminal concentration of acetate and propionate and increased acetate/propionate ratio and ruminal pH. In general, there is no difference between the diet containing corn and that containing citrus pulp in total replacement to corn. The use of wet brewer grain, however, reduces average daily gain, final body weight and feed efficiency.

  18. Desempenhos reprodutivo e produtivo de ovelhas Santa Inês suplementadas em diferentes fases da gestação Reproductive and productive development of Santa Inês ewes supplemented in different stages of pregnancy

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    Alexandre Agostinho Mexia

    2004-06-01

    Full Text Available Foram avaliados os comportamentos reprodutivo e produtivo de ovelhas Santa Inês, suplementadas em diferentes estádios de gestação, sendo NS = pastagem durante o dia e resíduo de fécula de mandioca no período noturno, durante a estação de monta e gestação, S46 = NS acrescido de suplementação (casca do grão de soja do 46º dia após o início da estação de monta até a parição e S100 = NS acrescido de suplementação (casca do grão de soja do 100º dia após o início da estação de monta até a parição. Foram utilizadas 94 ovelhas Santa Inês, acasaladas com cinco reprodutores Santa Inês e cinco Dorset. Os tratamentos não influenciaram o peso da ovelha aos 84 dias após início da suplementação (PO84, o peso da ovelha ao desmame (POD, a incidência de gestação (0 ou 1 no terço final (GEST, a taxa de parição (PAIÇÃO, taxa de natalidade (TN e prolificidade (PROLI, sendo os valores para tais características de 49,54 kg; 38,96 kg; 0,82; 0,71; 0,88 e 1,26, respectivamente. A suplementação materna, o sexo e o grupo genético do cordeiro não influenciaram o peso ao nascimento (PCN, aos 30 dias (PC30 e aos 60 dias de idade (PC60, apresentando valores médios de 3,47; 8,26 e 12,42 kg, respectivamente. O tipo de parto influenciou o PCN e o PC30. Não houve diferença para o peso total dos cordeiros ao nascimento (PTN, peso total dos cordeiros aos 30 dias (PT30 e peso total aos 60 dias de idade (PT60 entre os tratamentos dentro de cada tipo de parto e entre os grupos genéticos. As fases de suplementação da ovelha, o grupo genético dos cordeiros e o tipo de parto não influenciaram a mortalidade, do nascimento aos 30 e 60 dias de idade. O desempenho reprodutivo de ovelhas suplementadas no período de gestação, utilizando-se 0,5% do peso vivo, com casca do grão de soja, não foi alterado.The reproductive and productive behaviour of Santa Inês ewes were evaluated as a function of supplementation in different stages

  19. Morphometry of the ruminal mucosa of Santa Ines lambs fed with levels of palm kernel cake (Elaeis guineensis, from biodiesel productionMorfometria da mucosa ruminal de cordeiros Santa Inês alimentados com níveis de torta de dendê (Elaeis guineensis, oriunda da produção do biodiesel

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    Adriana Regina Bagaldo

    2011-08-01

    Full Text Available The work was carried out to determine the best level of inclusion of palm kernel cake in the concentrate-based morphometry evaluation of the ruminal mucosa in Santa Ines lambs. The experiment lasted 80 days, the Tifton-85 hay in a proportion 50 forage 50concentrado. The food was offered at 9:00 and 16:00. We used 32 sheep of Santa Ines, between 4 and 6 months and body weight of 22 ± 2.75 kg. The experiment was a completely randomized design with four treatments and eight repetitions. The treatments consisted in the inclusion levels of palm kernel cake (0.0, 6.5, 13.0 and 19.5% in the dry matter. Variables evaluated in the ruminal mucosa were: height, width, area, density and thickness of papillary muscular layer of the rumen in the regions of the dorsal and ventral sac. There were no significant differences in the region of the dorsal sac of the rumen for variables analyzed with the inclusion of palm kernel cake in the diet. The ventral surface papillary bag quadratic effect, whereas the thickness of muscular layer decreasing linear effect. The inclusion of up to 19.5% palm kernel cake had no significant effect on the morphology of the papillae may be included in the diet of Santa Ines lambs.O trabalho foi realizado com o objetivo de determinar o melhor nível de inclusão da torta de dendê no concentrado com base na avaliação da morfometria da mucosa ruminal em cordeiros Santa Inês. O período experimental foi de 80 dias, sendo o feno de tifton-85 utilizado na proporção 50 volumoso:50concentrado. O alimento foi ofertado às 9h00 e 16h00. Foram empregados 32 ovinos da raça Santa Inês, entre 4 e 6 meses e peso corporal de 22 ± 2,75kg. O delineamento experimental foi o inteiramente casualizado, com quatro tratamentos e oito repetições. Os tratamentos constituíram-se nos níveis de inclusão da torta de dendê (0,0; 6,5; 13,0 e 19,5 % na matéria seca da ração. As variáveis avaliadas na mucosa ruminal foram: altura, largura, superf

  20. PERFIL CITOLÓGICO VAGINAL DE OVELHAS DA RAÇA SANTA INÊS NO ACOMPANHAMENTO DO CICLO ESTRAL VAGINAL CYTOLOGY PROFILE FOR ACCOMPANIMENT TO ESTROUS CYCLE IN BREED SANTA INÊS EWES

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    José Adamir Torres de Souza

    2007-09-01

    Full Text Available

    O objetivo deste trabalho foi investigar o perfil citológico vaginal em ovelhas da raça Santa Inês, durante um ciclo estral completo. Selecionaram-se cinco fêmeas cíclicas criadas em sistema semi-intensivo, na Fazenda Pe-dras Santa em Araguaína, TO. Prepararam-se os esfregaços vaginais diariamente nas ovelhas cujo estro foi detectado por um rufião. Confeccionou-se um esfregaço vaginal por fêmea, em lâminas de vidro secas à temperatura ambiente e fixadas em álcool a 95%. Em seguida, foram coradas pelo método panótico rápido. As lâminas foram observadas ao microscópio óptico de luz com aumentos de 10 x e 40 x para contagem de 100 células por lâmina. Analisaram-se as características morfológicas e tintoriais das células epiteliais ao longo do ciclo estral, levando em consideração tanto as variáveis de cada fase do ciclo estral – proestro, estro, metaestro e diestro –, bem como os tipos celulares encon-trados – basal, parabasal, intermediária e anucleada. Os valores foram estudados por meio de ANOVA, ao nível de probabilidade de 5% pelo teste de Tukey. Na fase de estro, notou-se uma diferença do tipo celular superficial anucleada sobre os demais tipos (P<0,05. Concluiu-se que, através da citologia vaginal esfoliativa, podem-se diferenciar as fases do ciclo estral em ovelhas da raça Santa Inês.

    PALAVRAS-CHAVES: Ciclo estral, citologia vaginal, epitélio vaginal, ovelhas.

    The objective of this work was to establish a vaginal cytological profile in ewe of the Race Saint Inês, during a complete estrous cycle. Five created cyclical females in half-intensive system had been selected, in the Farm Rocks Saint, Araguaína, TO. The vaginal smears had been made daily during the estrous cycle, detected for a ruffian. One was confectioned vaginal smears for female, in dry glass slides to the ambient temperature and settled in alcohol 95% and in followed. They had been staining by the fast panótico method

  1. Plasma urea nitrogen and progesterone concentrations and follicular dynamics in ewes fed proteins of different degradability

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    Gustavo Bianchi Lazarin

    2012-07-01

    Full Text Available The effects of overfeeding with protein of different degradability on body condition, plasma urea nitrogen and progesterone concentrations, ovulation number and follicular dynamics were assessed in Santa Ines ewes. Twelve ewes were assigned to a randomized block design according to body weight and received overfeeding with soybean meal or with corn gluten meal or maintenance diet for 28 days before ovulation and during the next estrous cycle. Blood samples were taken on days 7, 14, 21, and 28 after the beginning of treatments for analysis of plasma urea nitrogen and on days 3, 6, 9, 12, and 15 into the estrous cycle for analysis of plasma urea nitrogen and progesterone. Follicular dynamics was monitored daily by ultrasound during one estrous cycle. Dry matter and crude protein intake, weight gain, plasma urea nitrogen concentration before ovulation, number of ovulations, diameter of the largest follicle of the 1st and of the 2nd waves and the growth rate of the largest follicle of the 1st wave were higher in the ewes that received overfeeding. The growth rate of the largest follicle of the 3rd wave was higher in the ewes fed maintenance diet. The back fat thickness, plasma urea nitrogen before ovulation and progesterone concentrations, diameter of the largest follicle of the 2nd wave and growth rate of the largest follicle of the 3rd wave were higher in ewes that received overfeeding with soybean meal. The growth rate of the largest follicle of the 1st wave was higher in ewes that received overfeeding with corn gluten meal. Overfeeding with protein-rich feeds may increase the ovulation number and with soybean meal, it may be effective in increasing plasma progesterone concentration in ewes.

  2. Ewing sarcoma

    Science.gov (United States)

    Bone cancer - Ewing sarcoma; Ewing family of tumors; Primitive neuroectodermal tumors (PNET); Bone neoplasm - Ewing sarcoma ... this tissue to help determine how aggressive the cancer is and what treatment may be best.

  3. Susceptibility to nematodes of Santa Inês, Bergamácia and Texel ewes on northwest of ParanáSusceptibilidade a nematóides em ovelhas Santa Inês, Bergamácia e Texel no Noroeste do Paraná

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    Graziela Aparecida Santello

    2011-12-01

    Full Text Available Aiming to measure the resistance of ewes against gastrintestinal nematodes, an experiment was conducted at Centro de Pesquisa do Arenito, of the Universidade Estadual de Maringá, located in the city of Cidade Gaúcha, northwest of Paraná. Ninety- four Santa Inês, 14 Bergamácia and 25 Texel ewes were used. The flock remained on Tanzânia (Panicum maximum cv. Jaq pasture during the day, being withdrawn indoors, with suspended battened floor, during the night, when they were provided cassava bagasse. The ewes were monitored monthly and individually regarding the amount of endoparasites, through egg counting per gram of feces (EPG, and worms culture for identification of the species of those endoparasites. The Santa Inês ewes presented had lower (P ? 0,05 susceptibility comparing to the breeds Texel and Bergamácia, being the averages of EPG 838,58; 1240,31 and 1821,33 respectively. The highest percentage of endoparasites corresponded to the Haemonchus contortus, showing that this was the main type of endoparasites responsible for the EPG levels, followed by Trichostrongylus colubriformis. The counting of EPG of Santa Inês ewes showed a cubical behaviour over the year of observation, reaching the higher level in October, month in which the giving births happened. The Texel and Bergamácia ewes also showed cubical behaviour during the year, however, the higher EPG levels happened in the months of May, June and July. The Santa Inês ewes were the least prone to infection by endoparasites.Com o objetivo de verificar a susceptibilidade de ovelhas à infecção por nematóides gastrointestinais foi realizado experimento no Centro de Pesquisa do Arenito (UEM, no município de Cidade Gaúcha, noroeste do Paraná. Foram utilizadas 94 ovelhas Santa Inês, 14 Bergamácia e 25 Texel. Os rebanhos permaneceram em pastagem de Tanzânia (Panicum maximum cv. Jaq no período diurno, sendo recolhidos em instalações cobertas, com piso ripado suspenso, no per

  4. Crescimento alométrico dos tecidos ósseo, muscular e adiposo na carcaça de cordeiros Santa Inês e Bergamácia Allometric growth of bone, muscular and fat tissues in carcass of Santa Ines and Bergamacia lambs

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    Cristiane Leal dos Santos

    2001-04-01

    Full Text Available O trabalho foi realizado com objetivo de realizar um estudo alométrico dos tecidos ósseo, muscular e adiposo na meia carcaça esquerda de cordeiros em crescimento. Foram utilizados 36 cordeiros machos inteiros, sendo 24 Santa Inês e 12 Bergamácia. Os animais foram confinados em gaiolas individuais e alimentados ad libitum. O abate ocorreu quando os animais atingiram os pesos vivos de 15, 25, 35 e 45 kg. Após a carcaça ter sido limpa e resfriada, foram obtidos os cortes comerciais a partir da meia carcaça esquerda. A quantidade dos diferentes tecidos foi obtida a partir da dissecação da perna, do lombo, da costeleta, costela/fralda e paleta. A quantidade total dos tecidos ósseo, muscular e adiposo foi obtida pela adição das quantidades de cada corte comercial. O estudo do desenvolvimento relativo da composição tecidual foi feito por meio do modelo de HUXLEY (1932. Constatou-se crescimento heterogônico negativo (b 1 para a gordura, em relação ao peso da ½ carcaça.The work was conducted with the objective to study the allometric growth of the bone, muscular and fat tissues in the left side of growing lamb carcasses. Thirty-six, twenty-four Santa Ines and twelve Bergamacia lambs were used. The animals were kept in individual pens and fed ad libitum diets. The slaughtering was done when the animals reached the live weight of 15, 25, 35 and 45 kg. The amount of the different tissues was obtained through the dissection of the left half of the carcass. The amount of the different tissues was obtained through the dissection of the leg, longissimus muscle, rib, breast and shoulder. The total amount of bone, muscle and fat tissues were obtained by the sum of each amount of commercial cut. The study of the relative tissue composition development was carried out using the model developed by HUXLEY (1932. A negative heterogonic (b 1 for the fat tissue in relation to the half side of the carcass was observed.

  5. Há equivalência entre a temperatura da membrana timpânica e a temperatura retal em ovinos Santa Inês normotérmicos? Is there equivalence between the tympanic membrane temperature and the rectal temperature in normothermic Santa Ines sheep?

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    Claudia Del Campo

    2008-09-01

    Full Text Available A utilização do termômetro de raios infravermelhos para a aferição da temperatura timpânica em animais tem se tornado uma alternativa prática na clínica veterinária. Em ovinos, a mensuração da temperatura timpânica não foi suficientemente comparada com a aferição da temperatura retal. Este estudo avaliou a equivalência entre a temperatura timpânica e a temperatura retal em 16 ovinos da raça Santa Inês. Durante a coleta de dados, a temperatura e a umidade relativa do ar foram monitoradas e não houve correlação entre estas e a temperatura corporal. A análise da equivalência, pelo método da diferença entre as temperaturas, resultou em temperaturas timpânicas mais baixas (entre 35 e 36,9°C, para ambos os ouvidos que a temperatura retal (entre 39 e 38°C. Os limites de concordância das comparações entre a temperatura retal e as temperaturas timpânicas foram acima do valor pré-estabelecido. A localização anatômica dos locais aferidos e o tipo de termômetro contribuíram para as diferenças de temperatura. A temperatura retal e a temperatura timpânica foram independentes, sugerindo não haver equivalência entre ambas.The use of infrared thermometers to obtain the tympanic temperature in animals has become a convenient alternative in veterinarian medicine practice. In sheep, tympanic and rectal temperatures have not yet been compared enough. This study evaluated the equivalence between the tympanic and the rectal temperatures in sixteen Santa Ines sheep. During data collection, air temperature and humidity were monitored and there was no discernible correlation between these and the ovine body temperature. The analysis of the equivalence, as measured by the method of the difference amongst temperatures, resulted in lower tympanic temperature (between 35 and 36.9°C, for both ears than the rectal temperature (between 38 and 39°C. The agreement limit of the comparisons between the rectal and tympanic temperatures

  6. Rendimento de Carcaça, Mensurações e Peso de Cortes Comerciais de Cordeiros Santa Inês e Bergamácia Alimentados com Dejetos de Suínos em Confinamento Dressing Percentage, Measures of Carcass and Weight of Commercial Joint Santa Ines and Bergamacia Lambs Fed with Swine Wastes in Confinement

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    Marcus Vinicius Morais de Oliveira

    2002-06-01

    Full Text Available Foram utilizados 21 cordeiros das raças Santa Inês e Bergamácia, confinados por um período de 75 dias, sendo alimentados com dietas contendo 24% de dejetos de suínos, na forma de biju (dejeto obtido pela raspagem e varredura do piso das baias de crescimento e terminação ou dejeto peneirado seco - DPS (dejeto obtido através da peneiração da parte sólida do material contido na lâmina d'água e na água da lavagem das baias. Os animais foram abatidos aos 210 dias de idade, sendo determinados o peso e o rendimento das carcaças, suas mensurações e o peso dos cortes comerciais. As diferentes dietas não afetaram o peso ao abate (PA, peso de carcaça quente (PCQ, rendimento de carcaça quente (RCQ, peso de carcaça fria (PCF, rendimento de carcaça fria (RCF e percentual de perda ao resfriamento (PPR. Os cordeiros da raça Bergamácia apresentaram maior PA, PCQ e PCF. Não foram verificadas diferenças entre as dietas ou entre as raças para os parâmetros: comprimento total, comprimento da perna, comprimento total da perna, comprimento interno, perímetro da garupa e largura de garupa. No entanto, foi verificada maior profundidade de tórax e espessura de gordura subcutânea nos cordeiros da raça Bergamácia. Também não foi encontrado nenhum efeito das dietas e das raças para os cortes paleta, carré, peito/fralda, lombo, pernil, braço anterior e braço posterior.Twenty-one lambs of the Santa Ines and Bergamacia breeds were confined by a period of 75 days and fed diets containing 24% of swine wastes, in biju form (obtained by the scratching and sweeping of the floor of the growth stalls and termination or dry sifted wastes - DSW (obtained through the sifting of the solid part of the material contained in the sheet of water and in the water of the wash of the stalls. The animals were slaughtered at 210 days of age, being determined the weight and measures of carcass, dressing percentage and commercial joints. There was no diet

  7. Performance, carcass and meat quality of ewes supplemented with magnesium oxide

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    Camila Constantino

    2014-01-01

    Full Text Available The objective of this study was to evaluate the performance, the carcass and meat characteristics of ewes supplemented with magnesium oxide. Eighteen 6-year-old Santa Ines ewes were used in a completely randomized experimental design, where three levels of supplementation (0.0, 0.1 and 0.2% magnesium oxide in the concentrate were tested, with six replicates. Final weight, weight gain, feed intake and feed conversion were not affected by levels of magnesium supplementation. Hot and cold carcass weights showed linear increasing and quadratic responses, respectively, according to supplementation with magnesium. Carcass measurements such as length, depth, and measures of arm and leg were not affected by supplementation. Depth and width of the longissimus muscle and rib-eye area were not affected; however, marbling and ether extract increased linearly with supplementation. Water loss and color were not affected. Lipid oxidation and shear force were not affected by supplementation, while the myofibrillar fragmentation index showed a quadratic regression. There was a linear decrease in pH with magnesium supplementation. Supplementation with magnesium can improve carcass and meat pH, but can act negatively by increasing the amount of marbling and ether extract of meat.

  8. Clinical findings related to intramammary infections in meat-producing ewes.

    Science.gov (United States)

    Blagitz, Maiara G; Souza, Fernando N; Batista, Camila F; Diniz, Soraia A; Haddad, João Paulo A; Benites, Nilson R; Melville, Priscilla A; Della Libera, Alice M M P

    2014-01-01

    The aim of this study was to investigate the relationship between clinical findings and bacterial isolation in milk samples of meat-producing ewes. The study was conducted in 17 commercial flocks and 550 udder halves from suckling Santa Ines ewes. Initially, the clinical examination of the mammary glands and teats was performed by visual inspection and palpation of the teats and udder halves; then a scoring system was devised for all the findings. After that, the strip cup test and the California mastitis test (CMT) were performed. Then, milk samples for somatic cell counts (SCCs) and bacteriological analyses were collected. Staphylococci bacteria were the main etiological agent isolated in the present study. Upon investigation of the correlations between bacterial isolation and the clinical findings, only the presence of teat injury, pendulous udder, and alterations in the palpation of the teat were associated with bacterial isolation. A significant correlation between bacteriologically positive milk samples and CMT and SCC was also found. Thus, some clinical findings appeared as a risk factor for bacteriologically positive milk samples and can be used as a tool in mastitis control programs. However, a complete and extensive diagnosis, an appropriate therapy, and an efficient mastitis control program will require the combination of clinical examination, microbiological tests, and SCC.

  9. Características e rendimentos de carcaça e de cortes em ovinos Santa Inês, alimentados com diferentes concentrações de energia metabolizável - doi: 10.4025/actascianimsci.v32i4.9684 Characteristics and yields of carcass and cuts in Santa Ines sheep fed with different concentrations of metabolizable energy - doi: 10.4025/actascianimsci.v32i4.9684

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    José Gilson Louzada Regadas Filho

    2010-10-01

    Full Text Available O objetivo do estudo foi avaliar o ganho de peso (GMD, conversão alimentar (CA, eficiência alimentar (EA, características de carcaça e dos cortes comerciais de ovinos Santa Inês, alimentados com diferentes concentrações de energia metabolizável (2,08; 2,28; 2,47 e 2,69 Mcal de EM kg-1 de MS. Vinte cordeiros, com idade e peso corporal médio de 50 dias e 13,00 ± 0,56 kg, respectivamente, foram distribuídos em blocos casualizados, com cinco repetições. Verificou-se efeito linear crescente (p 0,05 pelos níveis energéticos das rações. No entanto, os pesos de carcaça quente e fria, e o peso do corpo vazio, expressos em kg, apresentaram efeito quadrático (p This study evaluated the weight gain (ADG, feed conversion (FC, feed efficiency (FE, characteristics of carcass and retail cuts of Santa Inês sheep fed different levels of metabolizable energy (2.08, 2.28, 2.47 and 2.69 Mcal kg-1 of DM. Twenty lambs, with age and mean body weight of 50 days and 13 ± 0.56 kg, respectively, were distributed in randomized block design with five replications. We verified a linear increase effect (p 0.05 by the energy levels of the rations. Nevertheless, the weights of hot and cold carcass and theempty body , expressed in kg, presented quadratic effect (p < 0.05, as we increase the levels of metabolizable energy in experimental diets. The energy levels influenced the yield of rib and shoulder, as the loin eye area (p < 0.05. In conclusion, the manipulation of the energy level of the ration changes the ADG, the hot and cold carcass weight, the shoulder yield, the rib weight and the loin eye area of Santa Ines sheep.

  10. Composição corporal de cálcio e fósforo do útero gestante e da glândula mamária de ovelhas Santa Inês Calcium and phosphorus content in gravidic uterus and mammary gland of Santa Inês breed ewes

    Directory of Open Access Journals (Sweden)

    F.A. Souza

    2013-02-01

    Full Text Available Ovelhas Santa Inês com gestação simples e múltipla foram alimentadas com dietas formuladas para atender a 100% - grupo não restrito - e 85% - grupo restrito - das suas necessidades de energia metabolizável (EM e proteína bruta (PB. Os animais foram abatidos aos 140 dias de gestação para a retirada do útero da glândula mamária e do útero gestante, os quais foram analisados para o conteúdo de cálcio e de fósforo em função dos tratamentos. A restrição nutricional não influenciou as concentrações de cálcio e fósforo no feto e no útero gestante. Foi observado um aumento de 11,68 gramas de cálcio e de 6,37 gramas de fósforo para cada quilograma de massa fetal produzido aos 140 dias de gestação. As concentrações de cálcio e de fósforo do útero e das membranas foram mais baixas nas ovelhas gestantes submetidas à restrição nutricional. O número de fetos e o manejo nutricional não resultaram em alterações na concentração nem no conteúdo de cálcio e fósforo nos fluidos fetais. O conteúdo de cálcio e de fósforo no útero gestante teve como principal fator de variação o tamanho da massa fetal produzida.Santa Inês breed ewes with single and multiple gestations were fed diets to meet 100% - Group ad libitum - and 85% - restricted group - of metabolizable energy (ME and crude protein (CP needs. The animals were slaughtered at 140 days of gestation for the removal of the gravidic uterus and mammary gland which were analyzed for calcium and phosphorus content. The nutritional restriction did not influence the calcium and phosphorus concentrations in the fetus and the pregnant uterus. The calcium and phosphorus content in the gravidic utero increased 11.68 grams and 6.37 grams for each kilogram of fetal mass produced at 140 days of gestation respectively. The calcium and phosphorus concentration in the uterus and membranes were lower in pregnant ewes subjected to nutritional restriction. The number of fetuses

  11. Ines Karu tantsis end raamatusse / Kais Allkivi

    Index Scriptorium Estoniae

    Allkivi, Kais

    2008-01-01

    USAs ilmus raamat kõhutantsust "Kõhutants tähistamas püha naiselikkust" ("Belly Dance Celebrating the Sacred Feminine"). Raamatu autor on Martha Elena Burns. Eestlannadest on raamatus Ines Karu ja tema trupikaaslane Janne Mõistus. Lisaks fakte Ines Karust "Pühendunud tantsule"

  12. Ines Karu tantsis end raamatusse / Kais Allkivi

    Index Scriptorium Estoniae

    Allkivi, Kais

    2008-01-01

    USAs ilmus raamat kõhutantsust "Kõhutants tähistamas püha naiselikkust" ("Belly Dance Celebrating the Sacred Feminine"). Raamatu autor on Martha Elena Burns. Eestlannadest on raamatus Ines Karu ja tema trupikaaslane Janne Mõistus. Lisaks fakte Ines Karust "Pühendunud tantsule"

  13. Efeito do nível de energia metabolizável na composição dos tecidos da carcaça de cordeiros da raça Santa Inês Effect of metabolizable energy level on the carcass tissues composition of Santa Ines lambs

    Directory of Open Access Journals (Sweden)

    T.R.V. Almeida

    2009-12-01

    Full Text Available Estudou-se a influência da energia metabolizável (EM, pela inclusão de percentuais crescentes de fibra em detergente neutro (FDNf, proveniente de forragem, sobre a composição dos tecidos da carcaça de 64 cordeiros Santa Inês. Os tratamentos (dietas foram: dieta A - com 8,7% de FDNf; dieta B - com 17,3%; dieta C - com 26,0% e dieta D - com 34,7% de FDNf na dieta. Quatro animais de cada tratamento foram abatidos aos 43, 83, 123 e 173 dias. Os cordeiros que receberam as dietas A e B apresentaram maiores pesos dos tecidos ósseo (TO, muscular (TM, adiposo (TA e outros (OT na carcaça fria, a partir dos 83 dias de idade. O rendimento de TO na carcaça fria dos animais que receberam as dietas A e B foi menor, enquanto as proporções de TA foram maiores a partir dos 83 dias de idade. A regressão de cada variável, em função do consumo de EM total (Mcal, para cada tratamento, mostrou que a deposição de TA em cordeiros alimentados com a dieta A foi mais intensa.The effect of metabolizable energy level (ME, due to increasing levels of forage nitrogen detergent fiber (fNGF, on the carcass tecidual composition of 64 Santa Inês lambs was evaluated. Four treatments (diets were: diet A- fNDF; diet B- 17.3%; of fNDF; diet C- 26.0% of fNDF; and diet D- 34.7% of 8.7% fNDF in the diet. Four animals of each treatment were slaughtered at 43, 83, 123, and 173 days. Lambs fed diets A and B, showed higher weight of bonne tissue (BT, muscular tissue (MT, fatty tissue (FT, and other tissues (OT in cold carcass at 83 days of age. The percentage of BT in cold carcass of the lambs fed diets A and B was lower, and percentage of FT was higher, after 83 days of age. The regression of each variable on ME total intake (Mcal, for each treatment, suggested higher intensity of deposition of FT for lambs fed diet A.

  14. Composição corporal e exigências nutricionais em cálcio e fósforo para ganho e mantença de cordeiros Santa Inês dos 15 kg aos 25 kg de peso vivo Body composition and requirements for calcium and phosphorus for gain and maintenance of Santa Ines lambs from 15 to 25 kg of body weight

    Directory of Open Access Journals (Sweden)

    Luciana Castro Geraseev

    2000-02-01

    Full Text Available RESUMO - Este trabalho foi conduzido para determinar a composição corporal e estimar as exigências de cálcio e fósforo de cordeiros da raça Santa Inês. Foram utilizados 18 cordeiros machos inteiros, com peso médio inicial de 15 kg, divididos em três grupos: seis animais abatidos no início do experimento, para avaliar o conteúdo de cálcio e fósforo corporal, servindo como animais referência para o método do abate comparativo; seis animais alimentados ad libitum; e seis com alimentação restrita (em nível de mantença + 20%. Os cordeiros que receberam dietas ad libitum e restritas entraram no experimento aos pares e foram abatidos concomitantemente, quando o primeiro atingiu 25 kg de peso vivo. A composição corporal foi estimada a partir de equações de regressão do logaritmo da quantidade de cálcio e fósforo presentes no corpo vazio, em função do logaritmo do peso corporal vazio. As exigências líquidas de mantença e o coeficiente de absorção destes minerais foram determinados a partir da correlação entre a quantidade de mineral ingerida e a quantidade retida no corpo, enquanto as exigências líquidas para o ganho em peso foram estimadas a partir da derivação de equações de predição da composição corporal. As exigências líquidas de mantença, para animais entre 15 e 25 kg de peso vivo, foram 305 mg de Ca/dia e 325 mg de P/dia e as exigências líquidas por kg de ganho de peso vivo, para animais com 15 e 25 kg de peso vivo, 11,41 e 10,33 g Ca e 5,72 e 4,94 g P, respectivamente. Os coeficientes de absorção encontrados neste trabalho foram 0,44 e 0,55 para Ca e P, respectivamente.ABSTRACT - The research was carried out to determine body composition and calcium and phosphorus requirements of Santa Ines lambs. Eighteen entire male lambs with average initial live weight of 15 kg were used. The animals were allotted to three groups: six animals were slaughtered at the beginning of the experiment, to access the

  15. Stages of Ewing Sarcoma

    Science.gov (United States)

    ... tumor that forms from a certain kind of cell in bone or soft tissue . Ewing sarcoma may be found in the bones of the legs, arms, feet, hands, chest , pelvis , spine , or skull . Ewing sarcoma also may be found in the soft tissue of the trunk, arms, legs, head and neck, abdominal cavity , or ...

  16. MORFOLOGIA DA CÉRVICE DE OVELHAS SANTA INÊS ADULTAS NAS FASES LUTEÍNICA E FOLICULAR

    Directory of Open Access Journals (Sweden)

    Matheus Castro Franco

    2014-12-01

    Full Text Available The ovine cervix is irregularly shaped, making it a challenge to pass through it during artificial insemination. Thus, the aim of this study was to describe the morphological characteristics of the cervix of Santa Ines breed, comparing the phases of the estrous cycle. A total of 112 uteri were collected from non-pregnant ewes and silicone was injected into the lumen of the cervix in order to obtain a cast of the cervical canal. Mean length of the cervix was 41.33 ± 16.38 mm and the most frequent cervical ostium type found was the duck-beak (46%. Two rings were the minimum and seven were the maximum found in the cervix, with means of 4.70 ± 1.05 rings. Morphometric data from each cervical ring indicates that the inner circumference tapers in the middle portion and then becomes to enlarge again. No significant difference (p> 0.05 was found when comparing the luteal and follicular phases, or the types of cervix regarding to the values of the diameter of the folds, height, inside circumference, midpoint between the folds and distance from the opening to the folds. Under the studied conditions, we concluded that the development of semen applicator should take into account the morphometric limits found, although the morphology and morphometry of the ovine cervix is quite varied, with no standard patterns for the species, even when comparing the luteal and follicular phases.

  17. Ines Aru : "Mõtlen surmale sagedamini kui peaks" / Jaanus Kulli

    Index Scriptorium Estoniae

    Kulli, Jaanus, 1955-

    2005-01-01

    Ines Aru lühimängufilmis "Koputus väravale". Autor Richard Roht, režissöör ja stsenarist Kalev Hiller. Lisad: "Ines Aru lahked silmad ei sobinud nõiale" ja "Tahan teada, kas suudan inimese nutma panna"

  18. Ines Aru : "Mõtlen surmale sagedamini kui peaks" / Jaanus Kulli

    Index Scriptorium Estoniae

    Kulli, Jaanus, 1955-

    2005-01-01

    Ines Aru lühimängufilmis "Koputus väravale". Autor Richard Roht, režissöör ja stsenarist Kalev Hiller. Lisad: "Ines Aru lahked silmad ei sobinud nõiale" ja "Tahan teada, kas suudan inimese nutma panna"

  19. Psihološki vidiki pooperativne bolečine

    OpenAIRE

    Marinović, Monika

    2014-01-01

    Za razumevanje in učinkovito lajšanje pooperativne bolečine je potrebno razumeti, kakšno vlogo imajo psihološki dejavniki, ki vplivajo na doživljanje bolečine. Glavni cilj pri lajšanju pooperativne bolečine je zmanjšati odmerek zdravila in posledično zmanjšati stranske učinke, a še vedno zagotoviti ustrezen terapevtski učinek. Multidisciplinaren timski pristop je osnova za načrtno in sistematično lajšanje bolečine. Kako se posameznik odziva na pojav bolečine, je odvisno od starosti, okolja, p...

  20. Horton and Ewing Medalists

    Science.gov (United States)

    AGU has announced the recipients of the 1988 Robert E. Horton and Maurice Ewing medals. The recipient of the Robert E. Horton Medal for outstanding contributions to the geophysical aspects of hydrology will be Peter S. Eagleson of the Massachusetts Institute of Technology. Eagleson is the immediate Past-President of AGU.The recipient of the Maurice Ewing Medal for significant original contributions to understanding physical, geophysical, and geological processes in the ocean; and/or significant original contributions to scientific ocean engineering, technology, and instrumentation; and/or outstanding service to marine sciences is Wolfgang H. Berger of the Scripps Institution of Oceanography. The medal is presented jointly by the U.S Navy and AGU.

  1. General Information about Ewing Sarcoma

    Science.gov (United States)

    ... tumor that forms from a certain kind of cell in bone or soft tissue . Ewing sarcoma may be found in the bones of the legs, arms, feet, hands, chest , pelvis , spine , or skull . Ewing sarcoma also may be found in the soft tissue of the trunk, arms, legs, head and neck, abdominal cavity , or ...

  2. Treatment Option Overview (Ewing Sarcoma)

    Science.gov (United States)

    ... tumor that forms from a certain kind of cell in bone or soft tissue . Ewing sarcoma may be found in the bones of the legs, arms, feet, hands, chest , pelvis , spine , or skull . Ewing sarcoma also may be found in the soft tissue of the trunk, arms, legs, head and neck, abdominal cavity , or ...

  3. Collecting and Storing Biological Samples From Patients With Ewing Sarcoma

    Science.gov (United States)

    2016-11-21

    Askin Tumor; Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

  4. Diagnostic Study of Tumor Characteristics in Patients With Ewing's Sarcoma

    Science.gov (United States)

    2013-06-20

    Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

  5. Fiber fractions intake and digestibility for pregnant ewes with nutritional restriction or not Consumo e digestibilidade aparente das frações fibrosas por ovelhas gestantes submetidas ou não à restrição nutricional

    Directory of Open Access Journals (Sweden)

    Veridiana Basoni da Silva

    2010-03-01

    Full Text Available The fibrous fractions intake and digestibility in pregnant ewes submitted or not to nutritional restriction. 73 ewes were used at different pregnancy stages, with different fetuses numbers and 10 non-pregnant ewes, all of Santa Ines breed. Animals were submitted or not to nutritional restriction in accordance with the treatments. Animal nutritional requirements were calculated according to recommendations for predicted dry matter intake, energy (total digestible nutrients, TDN and crude protein (CP. From the animals which received nutritional restriction were removed 15% of energy (TDN and crude protein requirements. Ewes diet was composed by maize meal (Zea mays, soybean meal (Glycine max, Tifton chopped hay (Cynodon spp. and limestone. Experiment was conducted in completely randomized design with 2 x 2 x 4 factorial arrangement. Fetuses number influenced on intake and apparent digestibility of dry matter, organic matter and acid detergent fiber. Nutritional restriction, as expected, reduced dry matter intake and, consequently, apparent digestibility of nutrients studied. Cellulose intake was influenced significantly during pregnancy by the number of fetuses and nutritional management. It was observed that body size, age and fetuses number influenced in the capacity of neutral detergent fiber intake. This fact shows that ewes which did not reach the full growth should receive special attention with quantity and especially with forage quality.Objetivou-se avaliar o consumo e a digestibilidade das frações fibrosas por ovelhas gestantes mantidas ou não sob restrição nutricional. Foram utilizadas 73 ovelhas em diferentes fases da gestação, com diferentes números de fetos, e 10 ovelhas não prenhes, todas da raça Santa Inês. Os animais foram submetidos ou não à restrição nutricional de acordo com os tratamentos. As exigências nutricionais dos animais foram calculadas segundo as recomendações para consumo de matéria seca, energia

  6. Santa Muerte

    OpenAIRE

    Fraser, A.; The Photographers' Gallery; Trolley Books; Bar-Tur Foundation; Arts Council England

    2015-01-01

    The origins of Santa Muerte - a religion/cult that has been denounced as satanic by the Mexican Catholic Church - can be dated back hundreds of years. It was developed through a syncretism between indigenous Mesoamerican and Spanish Catholic beliefs and practices. Only in the last decade however has it become more predominant in Mexican society, where many commentators have noted its rise with the killing and violence associated with the war between rival drug cartels and the Mexican Governme...

  7. INES scale: French application to radioactive material transport

    Energy Technology Data Exchange (ETDEWEB)

    Sowinski, S.; Strawa, S.; Aguilar, J. [Direction Generale de la Surete Nucleaire et de la Radioprotection, Fontenay-aux-Roses (France)

    2004-07-01

    After getting the control of radioactive material transport in June 1997, the French safety Authority (ASN) decided to apply the INES scale to transport events. DGSNR (Directorate General for Nuclear Safety and Radioprotection) requests that radioactive material package consignors declare any event occurring during transportation, and has introduced the use of the INES scale adapted to classify transport events in order to inform the public and to have feedback. This paper deals with DGSNR's feedback during the past seven years concerning the french application of the INES scale. Significant events that occurred during transportation are presented. The French experience was used by IAEA to develop a draft guide in 2002 and IAEA asked countries to use a new draft for a trial period in July 2004.

  8. NADZOR NAD FINANČNIM POSLOVANJEM OBČINE

    OpenAIRE

    2013-01-01

    Občina je temeljna samoupravna lokalna skupnost. Gre za organizirano skupino ljudi, ki preko predstavnikov sama odloča o svojih, lokalnih zadevah, torej zadevah ki se tičejo življenja in dela prebivalcev na tem ozemlju. Je samostojna gospodarska enota z lastnim premoženjem. Lokalne zadeve javnega pomena financira občina iz lastnih virov, sredstev države in zadolževanja. Prihodki in izdatki za financiranje javne porabe občine morajo biti zajeti v proračunu občine (57. člen ZLS). Občina j...

  9. 1017-IJBCS-Article-Ines Edna Deleke Koko

    African Journals Online (AJOL)

    DR GATSING

    2 Laboratoire de Pharmacognosie et des huiles essentielles, Faculté des Sciences Techniques (UAC). ... chimiques contenus dans les drogues végétales utilisées pour le traitement ...... capables de se combiner aux protéines de la peau pour ...

  10. Ines Aru vabaduse väljadel / Maris Balbat

    Index Scriptorium Estoniae

    Balbat, Maris, 1936-

    2004-01-01

    Vabakutseline näitleja Ines Aru kolmest teatrirollist - Fonsia D. L. Coburni "Dzhinnimängus", strippari ema Laine Taube F. Echrenbuschi "Täismängus" Rakvere Teatris ja endine näitleja Melusine Melita J. Anouilh "Lindudes" Vanalinnastuudios

  11. Ines Aru vabaduse väljadel / Maris Balbat

    Index Scriptorium Estoniae

    Balbat, Maris, 1936-

    2004-01-01

    Vabakutseline näitleja Ines Aru kolmest teatrirollist - Fonsia D. L. Coburni "Dzhinnimängus", strippari ema Laine Taube F. Echrenbuschi "Täismängus" Rakvere Teatris ja endine näitleja Melusine Melita J. Anouilh "Lindudes" Vanalinnastuudios

  12. Indoor nature exposure (INE): a health-promotion framework.

    Science.gov (United States)

    Mcsweeney, J; Rainham, D; Johnson, S A; Sherry, S B; Singleton, J

    2015-03-01

    Engaging in outdoor nature-based spaces has significant positive physiological and psychological health benefits. Although the integration of nature into indoor spaces is rarely considered a health-promoting tool, it may be an effective method for increasing nature engagement in a largely urbanized world. This paper presents an overview of indoor nature exposure (INE) by summarizing the current evidence of INE through the use of a scoping methodology. Results show that INE can be a health-promoting tool through the interaction of nature-based stimuli and individual characteristics (e.g. gender, age). Moreover, the results of the current literature need to be interpreted with consideration to methodological issues, such as the lack of participant characteristics, the issue of exposure realism and little qualitative data to highlight individual experiences. The scoping review process allowed for the summation of results and for a framework to be created in order to better understand how INE is facilitated. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  13. Timo Palo jäine väljakutse

    Index Scriptorium Estoniae

    2014-01-01

    Fotonäitusest "Jäine väljakutse". Näitus koosneb kahest osast: National Geographicu fotograafi Paul Nickleni fotodest "Polar Obsession" ja Eesti polaarränduri Timo Palo retke põhjapooluselt Teravmägede saarestikku kirjeldavast väljapanekust

  14. Characterization of a neutron imaging setup at the INES facility

    Energy Technology Data Exchange (ETDEWEB)

    Durisi, E.A., E-mail: elisabettaalessandra.durisi@unito.it [Università di Torino, Dipartimento di Fisica, Via Pietro Giuria 1, 10125 Torino (Italy); Istituto Nazionale di Fisica Nucleare—Sezione di Torino, Via Pietro Giuria 1, 10125 Torino (Italy); Visca, L. [Università di Torino, Dipartimento di Fisica, Via Pietro Giuria 1, 10125 Torino (Italy); Istituto Nazionale di Fisica Nucleare—Sezione di Torino, Via Pietro Giuria 1, 10125 Torino (Italy); Albertin, F.; Brancaccio, R. [Istituto Nazionale di Fisica Nucleare—Sezione di Torino, Via Pietro Giuria 1, 10125 Torino (Italy); Corsi, J. [Università di Torino, Dipartimento di Fisica, Via Pietro Giuria 1, 10125 Torino (Italy); Istituto Nazionale di Fisica Nucleare—Sezione di Torino, Via Pietro Giuria 1, 10125 Torino (Italy); Dughera, G. [Istituto Nazionale di Fisica Nucleare—Sezione di Torino, Via Pietro Giuria 1, 10125 Torino (Italy); Ferrarese, W. [Università di Torino, Dipartimento di Fisica, Via Pietro Giuria 1, 10125 Torino (Italy); Istituto Nazionale di Fisica Nucleare—Sezione di Torino, Via Pietro Giuria 1, 10125 Torino (Italy); Giovagnoli, A.; Grassi, N. [Fondazione Centro per la Conservazione ed il Restauro dei Beni Culturali “La Venaria Reale”, Piazza della Repubblica, 10078 Venaria Reale, Torino (Italy); Grazzi, F. [Consiglio Nazionale delle Ricerche, Istituto dei Sistemi Complessi, Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze (Italy); Lo Giudice, A.; Mila, G. [Università di Torino, Dipartimento di Fisica, Via Pietro Giuria 1, 10125 Torino (Italy); Istituto Nazionale di Fisica Nucleare—Sezione di Torino, Via Pietro Giuria 1, 10125 Torino (Italy); and others

    2013-10-21

    The Italian Neutron Experimental Station (INES) located at the ISIS pulsed neutron source (Didcot, United Kingdom) provides a thermal neutron beam mainly used for diffraction analysis. A neutron transmission imaging system was also developed for beam monitoring and for aligning the sample under investigation. Although the time-of-flight neutron diffraction is a consolidated technique, the neutron imaging setup is not yet completely characterized and optimized. In this paper the performance for neutron radiography and tomography at INES of two scintillator screens read out by two different commercial CCD cameras is compared in terms of linearity, signal-to-noise ratio, effective dynamic range and spatial resolution. In addition, the results of neutron radiographies and a tomography of metal alloy test structures are presented to better characterize the INES imaging capabilities of metal artifacts in the cultural heritage field. -- Highlights: A full characterization of the present INES imaging set-up was carried out. Two CCD cameras and two scintillators (ZnS/{sup 6}LiF) of different thicknesses were tested. Linearity, effective dynamic range and spatial resolution were determined. Radiographies of steep wedges were performed using the highest dynamic range setup. Tomography of a bronze cube was performed using the best spatial resolution setup.

  15. Plasma folic acid cutoff value, derived from its relationship with homocyst(e)ine

    NARCIS (Netherlands)

    Brouwer, D A; Welten, H T; Reijngoud, D J; van Doormaal, J J; Muskiet, F A

    1998-01-01

    We established the cutoff value for plasma folic acid, using plasma homocyst(e)ine as the functional marker. To do this, we investigated the relationship of the plasma folic acid of 103 apparently healthy adults with their fasting plasma homocyst(e)ine and with their plasma homocyst(e)ine 6 h after

  16. Serum profile of cytokines interferon gamma and interleukin-10 in ewes subjected to artificial insemination by cervical retraction.

    Science.gov (United States)

    Alvares, C T G; Cruz, J F; Romano, C C; Brandão, F Z

    2016-04-15

    This study evaluated the influence of artificial insemination (AI) by cervical retraction (CRI) on serum levels of interferon gamma (IFNγ) and interleukin-10 (IL-10) in ewes. Synchronized pluriparous Santa Inês ewes were subjected to natural mating (NM, n = 8) and AI, which was performed for a fixed time (55 ± 1 hour) by CRI (n = 8) or laparoscopy (n = 8). Ewes were classified as pregnant, with return to estrus (RE) or with embryonic loss (EL). Blood samples were collected on Day 0, Day 3, Day 5, Day 12, and Day 17 (Day 0 = AI/NM) for progesterone dosage and cytokines were quantified from Day 0 to Day 12. Progesterone levels were constant, except for a decrease in ewes with RE at Day 17 (P IL-10 levels at any time, with averages of 642.1, 713.2, and 741.2 pg/mL for IFNγ and 667.1, 616.8, and 721.1 pg/mL for IL-10 when using CRI, laproscopy, and NM, respectively. Regarding the physiological status, ewes with EL had lower serum levels of IFNγ and IL-10 than pregnant ewes and ewes with RE, regardless of the reproductive method used, with averages of 769.1, 714.9, and 555.7 pg/mL for IFNγ and 713.8, 699.3, and 578.7 pg/mL for IL-10 in pregnant ewes, ewes with RE and EL, respectively (P IL-10 and does not induce an inflammatory reaction that can compromise pregnancy.

  17. Analisis Semiotik Fashion Ines Ariani Sebagai Bentuk Presentasi Diri

    Directory of Open Access Journals (Sweden)

    Monica Stella Angelina

    2015-12-01

    Full Text Available Fashion can be seen from the side semoitikanya that denotation and connotation. Like the black color that has connotations mysterious, bold, independent, and stylish, yellow color that symbolizes joy and a sense of spirit. Tiger spotted pattern connotes bold. Clothes that show the shape of the body shape connotes the online, open-minded, and confident. Denotation and connotation of this it can be concluded that Ines presenting himself as someone who is brave, open, cheerful, and stylish. Fashion and clothing are included in it has a deeper function than as body armor and kesopan that as the way a person communicates where fashion clothing is non-verbal communication that is artifactual. It can be seen that one can judge others simply on appearances alone. Even generally someone will first see the appearance of others before making conversation. This conversation function to verify whether the accepted meaning when just looking at clothes only in accordance with the meaning of a conversation or when it is doing the opposite. Although a person can wear to present themselves as it is, but nonetheless in reality there is an element of performance in it. It is also likely to be experienced by Ines, where in addition wants to present himself, Ines also wants the fashion that he was wearing viewed and became the center of attention of the crowd. Fashion dapat dilihat secara semoitikanya yaitu dari sisi denotasi dan konotasinya. Seperti warna hitam yang memiliki konotasi misterius, berani, mandiri, dan stylish, warna kuning yang melambangkan keceriaan dan rasa semangat. Pattern totol harimau yang berkonotasi berani. Bentuk pakaian yang memperlihatkan bentuk tubuh berkonotasi daring, open-minded, dan percaya diri. Dari denotasi dan konotasi inilah dapat diambil kesimpulan bahwa Ines mempresentasikan dirinya sebagai seseorang yang berani, terbuka, ceria, dan stylish. Fashion dan pakaian yang termasuk di dalamnya memiliki fungsi yang lebih mendalam selain

  18. Effects of GnRH administration on ovulation and fertility in ewes subjected to estrous synchronization

    Directory of Open Access Journals (Sweden)

    Amanda dos Santos Cavalcanti

    2012-06-01

    Full Text Available The objective of this study was to verify the effects of GnRH on ovulation and pregnancy of ewes subjected to a short-term synchronization of estrus. Santa Inês and crossbred Santa Inês/Dorper ewes received 60 mg MAP sponges during 6 days plus 300 IU eCG and 30 µg d-cloprostenol 24 h prior to sponge withdrawal (SW. Ewes were assigned to receive 0.9% NaCl solution (Tcontrol; n = 32 or 25 µg GnRH (licerelin, T GnRH; n = 34 24 hours after SW. Each group was assigned to intrauterine insemination by laparoscopy (n = 25 or to natural mating (n = 41. Artificial insemination was performed with a single dose of fresh semen. For controlled mating, females were exposed to males 12, 24, 36 and 48 hours after SW. Ten females per treatment were subjected to transrectal ultrasound examination at 12-hour intervals (SW to 60 hours after. Estrous response (100.0% vs 95.2%, interval from SW to estrus (32.9±7.4 vs 29.8±6.9 hours, estrous length (37.4±9.0 vs 31.5±10.4 hours, pregnancy rates (57.0% vs 41.0%, ovulation rate (100.0% vs 90.0%, number of ovulations/ewe (1.1±0.3 vs 1.2±0.4, maximum follicular diameter (6.4±0.7 vs 6.1±0.6 mm, interval from SW to ovulation (59.1±3.5 vs 58.4±3.5 hours did not differ between Tcontrol and T GnRH, respectively. Administration of GnRH 24 hours after SW does not improve ovulation or pregnancy rate in estrous synchronization in ewes.

  19. Anatomical surgical arterial segments of the kidneys of Santa Inês ovines

    Directory of Open Access Journals (Sweden)

    Antônio Chaves de Assis Neto

    2007-03-01

    Full Text Available The main goal of the study was describe the distribution of the renal arteries of the renal parenchyma and the proportional area of the arterial vascular system. The renal arterial vascularization in Santa Ines ovines was analyzed in fifteen pairs of organs of male adult animal, after attainment of vascular models through the techniques of corrosion and arteriography. The renal artery always appeared single, and before reaching the renal hilus, it bifurcated into sectorial dorsal and ventral arteries, giving rise to the segmentary arteries which varied from 6 to 10 in number in the right kidney and 7 to 11 in the left kidney. These vessels vascularized independent areas in each renal sector, the renal arterial segments, separated by non-vascularized planes. Bilateral symmetry of the arterial segmentation was found in 13.33% of cases. In accordance with the arterial characterization, the realization of setoriectomy and segmentectomy on the kidneys of Santa Ines ovines is therefore deemed possible.

  20. Reproductive parameters on hair sheep (Morada Nova and Santa Inês reared in intensive systems in Southeastern Brazil

    Directory of Open Access Journals (Sweden)

    André Torres Geraldo

    2013-12-01

    Full Text Available In southeastern Brazil, the Santa Inês ewes is one of the most used to produce early slaughtering crossbred lambs. The Morada Nova breed is reared only in some regions of Brazil and has a very small number of animals and flocks, but ewes have potential to be used for lamb production in the southeast, due to their adaptability to tropical conditions. This experiment aims to evaluate the reproductive potential of Morada Nova ewes to produce early lambs for slaughter. The study was carried out at Instituto de Zootecnia, city of Nova Odessa, located in São Paulo State, Brazil. Forty-nine adult Santa Inês (SI ewes with 51.8 ± 7.07 kg of initial body weight and forty-nine Morada Nova (MN with 33.1 ± 4.98 were used. During pregnancy the ewes were reared on intensive grazing systems with rotational grazing on Aruana grass pasture (Panicum maximum cv.IZ-5, and in the final third of gestation received corn silage ad libitum and a concentrate mixture (400 g/day with 16% crude protein and 80% of total digestible nutrient (TDN. The length of pregnancy, calculated through the date of mating and date of birth; prolificacy rate obtained by the number of lambs born per ewes; percentage of multiple births (% and ewe’s weight at lambing (kg were calculated. Statistical analysis was carried using GLM procedure of SAS ®. The birth weight of MN ewes was lower than the SI ewes, which is a reflection of their smaller size, however, the other reproductive parameters were similar between genotypes. These results highlight the potential use of Morada Nova ewes, as smaller maternal breed, for lamb production, which is favorable for production system that seeks sustainable intensification and optimization of resources, especially food.

  1. Performance and nematode infection of ewe lambs on intensive rotational grazing with two different cultivars of Panicum maximum.

    Science.gov (United States)

    Costa, R L D; Bueno, M S; Veríssimo, C J; Cunha, E A; Santos, L E; Oliveira, S M; Spósito Filha, E; Otsuk, I P

    2007-05-01

    The daily live weight gain (DLWG), faecal nematode egg counts (FEC), and packed cell volume (PCV) of Suffolk, Ile de France and Santa Inês ewe lambs were evaluated fortnightly for 56 days in the dry season (winter) and 64 days in the rainy season (summer) of 2001-2002. The animals were distributed in two similar groups, one located on Aruana and the other on Tanzania grass (Panicum maximum), in rotational grazing system at the Instituto de Zootecnia, in Nova Odessa city (SP), Brazil. In the dry season, 24 one-year-old ewe lambs were used, eight of each breed, and there was no difference (p > 0.05) between grasses for DLWG (100 g/day), although the Suffolk had higher values (p < 0.05) than the other breeds. In the rainy season, with 33 six-month-old ewe lambs, nine Suffolk, eight Ile de France and 16 Santa Inês, the DLWG was not affected by breed, but it was twice as great (71 g/day, p < 0.05) on Aruana as on Tanzânia grass (30 g/day). The Santa Inês ewe lambs had the lowest FEC (p < 0.05) and the highest PCV (p < 0.05), confirming their higher resistance to Haemonchus contortus, the prevalent nematode in the rainy season. It was concluded that the best performance of ewe lambs on Aruana pastures in the rainy season is probably explained by their lower nematode infection owing to the better protein content of this grass (mean contents 11.2% crude protein in Aruana grass and 8.7% in Tanzania grass, p < 0.05) which may have improved the immunological system with the consequence that the highest PCV (p < 0.05) observed in those animals.

  2. Wastage of ova in young Merino ewes.

    Science.gov (United States)

    de Blockey, M A; Parr, R A; Restall, B J

    1975-06-01

    Eight sub-flocks each of 48 to 51 Merino ewes were mated for 18 days with 1 ram to each subflock. Four of the sub-flocks were of non-parous 1.5-year-old ewes and the other 4 were of parous 2.5-year-old ewes. Fertilisation rates for the subflocks of 1.5-year-old ewes varied from 83 to 94%, and the sub-flocks of 2.5-year-old ewes ranged from 81 to 94%. By day 29 post coitum 42% and 56% of 1.5-year-old ewes in sub-flocks 1 and 2 respectively were no longer pregnant. Embryonic mortality was low in other sub-flocks of 1.5- and 2.5-year-old ewes. Virtually all embryonic death occurred after day 12 post coitum. The sporadic occurrence of high ova wastage in maiden 1.5-year-old ewes in this experiment and in others is discussed in relation to the short duration of oestrus in young ewes and the great variation in service activity of rams.

  3. Studies of pituitary function in lactating ewes.

    Science.gov (United States)

    Restall, B J; Kearins, R D; Starr, B G

    1977-03-01

    The release of LH from the pituitary of lactating ewes was studied. In Exp. 1, ewes were injected with 50 microng oestradiol benzoate (OB), 2-0 mg testosterone propionate (TP) or oil only (control) on days 5, 10, or 20 after lambing. LH was measured in peripheral plasma samples obtained 20-38 h after treatment, and the ovulations were recorded. The number of ewes in which an LH release was detected, and the amount released, declined between Day 5 and 20 after OB treatment but increased after TP treatment. The releases of LH were not always accompanied by ovulation and the incidence of ovulation was higher in ewes treated with TP. In Exp. 2, lactating ewes were injected with 1 or 5 (at 2-h intervals) doses of 50 microng Gn-RH, on Days 12 or 25 after lambing. LH was measured in peripheral plasma samples collected every 2 h for 10 h and every 3 h for a further 70 h. Release of LH occurred in all ewes, the amount being greater in ewes receiving multiple injections and in ewes treated on Day 25. The incidence of ovulation was higher after treatment on Day 25. Multiple injections of Gn-RH appeared to reduce the incidence of abnormal corpora lutea.

  4. Ewing's Sarcoma and Second Malignancies

    Directory of Open Access Journals (Sweden)

    Joshua D. Schiffman

    2011-01-01

    Full Text Available Ewing's sarcoma (ES is a rare tumor that is most common in children and young adults. Late effects of ES therapy include second cancers, a tragic outcome for survivors of such a young age. This paper will explore the frequencies and types of malignancies that occur after ES. Additionally, it will review how second malignancies have changed with the shift in treatment from high-dose radiation to chemotherapy regimens including alkylators and epipodophyllotoxins. The risk of additional cancers in ES survivors will also be compared to survivors of other childhood cancers. Finally, the possible genetic contribution to ES and second malignancies will be discussed.

  5. Therapeutic Trial for Patients With Ewing Sarcoma Family of Tumor and Desmoplastic Small Round Cell Tumors

    Science.gov (United States)

    2016-08-25

    Desmoplastic Small Round Cell Tumor; Ewing Sarcoma of Bone or Soft Tissue; Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

  6. Improved data extraction procedures for IUE Low Resolution Spectra The INES System

    CERN Document Server

    Rodríguez-Pascual, P M; Schartel, N; Wamsteker, W

    1999-01-01

    We present the extraction and processing of the IUE Low Dispersion spectra within the framework of the ESA ``IUE Newly Extracted Spectra'' (INES) System. Weak points of SWET, the optimal extraction implementation to produce the NEWSIPS output products (extracted spectra) are discussed, and the procedures implemented in INES to solve these problems are outlined. The more relevant modifications are: 1) the use of a new noise model, 2) a more accurate representation of the spatial profile of the spectrum and 3) a more reliable determination of the background. The INES extraction also includes a correction for the contamination by solar light in long wavelength spectra. Examples showing the improvements obtained in INES with respect to SWET are described. Finally, the linearity and repeatability characteristics of INES data are evaluated and the validity of the errors provided in the extraction is discussed.

  7. Santa and the Moon

    NARCIS (Netherlands)

    Barthel, P.

    2012-01-01

    This article reflects on the use of illustrations of the Moon in images of Santa Claus, on Christmas gift-wrapping paper and in children's books, in two countries which have been important in shaping the image of Santa Claus and his predecessor Sinterklaas: the USA and the Netherlands. The appearanc

  8. Santa and the Moon

    NARCIS (Netherlands)

    Barthel, P.

    This article reflects on the use of illustrations of the Moon in images of Santa Claus, on Christmas gift-wrapping paper and in children's books, in two countries which have been important in shaping the image of Santa Claus and his predecessor Sinterklaas: the USA and the Netherlands. The

  9. Novel Combination Chemotherapy for Localized Ewing Sarcoma

    Science.gov (United States)

    In this clinical trial, researchers will test whether the addition of the drug combination vincristine, topotecan, and cyclophosphamide to a standard chemotherapy regimen improves overall survival in patients with extracranial Ewing

  10. Procholecystokinin as marker of human Ewing sarcomas

    DEFF Research Database (Denmark)

    Reubi, Jean Claude; Koefoed, Pernille; Hansen, Thomas von O

    2004-01-01

    PURPOSE: Ewing sarcoma is a rapidly growing mesenchymal tumor in young adults. Although it was shown previously to express the cholecystokinin (CCK) gene, it is unknown whether CCK gene expression is detectable at protein level in Ewing sarcoma tumor cell lines, in tumor tissue, and in plasma fro...... in human cancer; Ewing sarcomas synthesize and secrete proCCK that can be identified in plasma as circulating tumor marker....... Ewing sarcoma patients, and, if so, whether CCK peptides might play a role as tumor markers. EXPERIMENTAL DESIGN: CCK gene expression was evaluated with in situ hybridization or reverse transcription-PCR in tumor tissue. CCK precursors and bioactive CCK were measured with specific RIAs in tumor tissue...

  11. ewes

    Directory of Open Access Journals (Sweden)

    M. R. Dally

    2004-01-01

    Full Text Available Con el fin de determinar la tasa de ovulación, parición, tamaño de la camada y supervivencia embrionaria, 225 borregas de siete genotipos se examinaron mediante endoscopio 7-8 días después de su cruza. Como resultado se encontró que un mayor número de ovulaciones unilaterales sencillas y dobles procedieron del ovario derecho (P0.05. Por otra parte, no se encontró diferencia en la supervivencia embrionaria (P>0.01 al comparar entre ovulaciones sencillas, dobles y triples (69.8%, 76.0% y 63.0%, respectivamente ni entre las ovulaciones unilaterales y bilaterales. La línea cuatera Targhee seleccionada (TW produjo las camadas más numerosas (media = 2.0±1.4 mientras que el rebaño Targhee comercial produjo las menos numerosas. La línea ½ Targhee, ¼ Barbados, ¼ Dorset mostró la tasa de parición mayor (94%, seguida de la Polypay (87%, sin encontrarse diferencia (P>0.05 entre estas dos líneas. Se concluye que: el ovario derecho es más activo que el izquierdo en cuanto a la producción de óvulos, de entre los genotipos estudiados; las ovulaciones dobles fueron más frecuentes que las sencillas y triples, y la línea cuatera Targhee seleccionada produjo las camadas más numerosas en comparación con el hato comercial Targhee o sus cruzas.

  12. Osteosarcoma with apparent Ewing sarcoma gene rearrangement

    OpenAIRE

    Mathias, Melissa; Chou, Alexander J; Meyers, Paul; Shukla, Neerav; Hameed, Meera; Agaram, Narasimhan; Wang, Lulu; Berger, Michael F.; Walsh, Michael; Kentsis, Alex

    2016-01-01

    Poorly differentiated round cell sarcomas present diagnostic challenges due to their variable morphology and lack of specific immunophenotypic markers. We present a case of a 15-year-old female with a tibial tumor that exhibited features of Ewing-like sarcoma, including apparent rearrangement of the EWSR1 gene. Hybridization capture-based next-generation DNA sequencing showed evidence of complex genomic rearrangements, absence of known pathogenic Ewing-like chromosome translocations, and dele...

  13. Quality of aged ewe meat in vacuum-packaging system for different storage periodsQualidade da carne maturada de ovelhas em sistema de embalagem a vácuo durante diferentes períodos de acondicionamento

    Directory of Open Access Journals (Sweden)

    Elzânia Sales Pereira

    2012-02-01

    Full Text Available Consumers believe tenderness to be most important organoleptic characteristic of meat. However, there is great variability in the tenderness of meat available to consumers; one method to reduce the variability and improve tenderness would be to promote meat aging. The aim of this study was to evaluate the quality of aged ewe meat. The experiment was conducted at the State University of Londrina. It was used eighteen Santa Ines ewes. After slaughter, the Longissimus dorsi muscle were collected and subjected to treatment, three different aging times: zero, four and eight days at 5 ± 2°C. The increase in aging time caused a decrease in pH. The L*, a* and c* values increase linearly with the aging period. The b* and h* values showed a quadratic regression. The mesophilic and psychrotrophic count showed a linear increase. The myofibrillar fragmentation index showed a quadratic regression, and the shear force decreased linearly. In a sensory analysis, a difference in the odor intensity of the meat was observed. The microbiological count indicated that the meat was fit for consumption. The aging promoted improvements in the quality of sheep meat. Os consumidores acreditam que a maciez é a característica organoléptica mais importante da carne. No entanto, há grande variabilidade na maciez da carne disponível para os consumidores, um método de reduzir a variabilidade e melhorar a maciez seria promover a maturação da carne. O objetivo deste estudo foi avaliar a qualidade da carne maturada de ovelhas. O experimento foi conduzido na Universidade Estadual de Londrina. Foram utilizadas 18 ovelhas da raça Santa Inês. Após o abate, o músculo Longissimus dorsi foram coletados e submetidos ao tratamento, três diferentes tempos de maturação: zero, quatro e oito dias a 5 ± 2 ° C. O aumento do tempo de maturação provocou uma redução no pH. Os valores de L *, a * e c* aumentam de forma linear com o tempo de maturação. Os valores b * e h

  14. Relationships among ewe milk production and ewe and lamb forage intake in Suffolk and Targhee ewes nursing single or twin lambs.

    Science.gov (United States)

    Ramsey, W S; Hatfield, P G; Wallace, J D

    1998-05-01

    Suffolk and Targhee ewes (30 each) with single or twin lambs were used in four periods beginning in late gestation and continuing through weaning to evaluate breed differences in milk production, lamb BW, and DMI by ewes and lambs. In Periods 1 (late gestation) and 2 (early lactation), ewes (Period 1) and ewes with lambs (Period 2) were individually penned, fed .45 kg of barley x ewe(-1) x d(-1) and allowed ad libitum access to chopped alfalfa. Ewes and lambs grazed native range in Periods 3 and 4. Grazed forage DMI was estimated using chromic oxide. Estimates of milk production were obtained by handmilking. Average lamb age was 4, 45, and 73 d at the beginning of Periods 2, 3, and 4, respectively. Milk production tended (P = .20) to be greater for Suffolk than for Targhee ewes. Targhee ewes produced 85% more (P = .001) wool than Suffolk ewes. From 33 d prepartum to 89 d postpartum, Suffolk ewes consistently weighed more (P = .001) than Targhee ewes. Suffolk ewe BW loss (-.15 kg/d) was greater (P = .01) than Targhee ewe BW loss (-.02 kg/d) from 33 d prepartum to 6 d postpartum. From 6 to 89 d postpartum BW gain did not differ (P = .69; .05 kg/d) between breeds. From birth to 89 d postpartum, Suffolk lambs consistently weighed more than Targhee lambs (P = .003). From birth to 89 d postpartum, ADG was greater for Suffolk than for Targhee lambs (P = .006). Targhee ewes consumed 25% more (P = .01) feed over the course of the study than did Suffolk ewes. Grazed forage DMI by Targhee lambs was 26% greater (P = .01) than DMI by Suffolk lambs. When meat production is the primary income from sheep, one potential advantage of Suffolks compared with Targhees is more rapid gain with less feed intake.

  15. Comparison of energy rationing systems for late gestation ewes: Impacts on ewe and lamb performance.

    Science.gov (United States)

    Campion, F P; McGovern, F M; Lott, S; Fahey, A G; Creighton, P; Boland, T M

    2016-08-01

    The objectives of this study were 1) to compare the effects of a ME () or a NE () system for rationing ewes during late gestation on ewe and progeny performance and 2) to investigate incremental increases in NE allocation above 100% of recommendation during late gestation on ewe and progeny performance. Fifty-two twin-bearing ewes ( = 13 per treatment) were rationed to either 100% of recommended ME requirements (100% ME) or 100, 110, or 120% of recommended NE requirements (100% NE, 110% NE, and 120% NE) from d 112 of gestation to parturition. Mean energy intake, measured as ME and NE, from Day 112 of gestation to parturition was higher in all NE treatments compared with 100% ME ewes ( = 0.01). Ewes offered the 3 NE treatments had a higher live weight at parturition compared with 100% ME ewes ( = 0.02), with 100% NE and 120% NE ewes still being heavier than 100% ME ewes at 35 d postpartum ( = 0.02). Increasing NE allowance resulted in a linear decrease in the level of BCS loss prepartum ( = 0.01) and a linear increase in the level of BCS loss postpartum ( = 0.01). There was no difference observed between any of the treatments in total colostrum produced to 18 h postpartum ( = 0.29) or in total colostrum intake to 18 h postpartum ( = 0.27). Increasing maternal NE allowance led to a linear increase in lamb serum IgG concentration at 24 h postpartum ( = 0.03). The estimated milk production of 120% NE ewes tended to be higher than all other treatments at wk 6 of lactation ( = 0.08). Colostral SFA levels from 100% ME ewes was lower than that of all 3 NE treatments ( = 0.01), and unsaturated fatty acid (UFA) levels in colostrum of the 100% ME ewes were lower than those of the 100% NE ewes ( = 0.01). Cumulative levels of milk SFA, UFA, and MUFA did not differ between treatments ( = 0.19). Lamb growth rates during the first 5 wk postpartum were unaffected by treatment ( = 0.18) as were days to slaughter ( = 0.34). It can be concluded that both ME and NE systems used in this

  16. Compilation of INES (International Nuclear Event Scale) information. Japanese translation (Vol.2)

    Energy Technology Data Exchange (ETDEWEB)

    Watanabe, Norio [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2001-03-01

    The International Nuclear Event Scale (INES) is a means designed for providing prompt, clear and consistent information related to nuclear events, that occurred at nuclear power plants and at other nuclear facilities, and facilitating communication between the nuclear community, the media and the public on such events. The INES is jointly operated by the International Atomic Energy Agency (IAEA) and the Nuclear Energy Agency of the Organization for Economic Co-operation and Development (OECD/NEA). Nuclear events reported to the INES Information System from member countries of IAEA and/or OECD/NEA are rated by the 'Scale', a consistent safety significance indicator. The scale runs from level 0, for events with no safety significance, to level 7 for a major accident with widespread health and environmental effects. The INES was introduced in March 1990 for a trial and then formally adopted in March 1992. In Japan, the INES was formally introduced in August 1992. The Japan Atomic Energy Research Institute (JAERI) has been receiving the INES information through the Science and Technology Agency, promptly translating into Japanese and providing to the relevant sections inside and outside JAERI. As well, we published the report compiling the Japanese translation of individual INES reports until May 31, 1998. Since then, we have developed a world-wide-web database for the Japanese translation and made it available to the public through the internet. This report compiles the Japanese version of approximately 70 INES reports we received from June 1, 1998 to December 31, 2000. (author)

  17. Sex of littermate twin affects lifetime ewe productivity

    Science.gov (United States)

    Ewe productivity is synonymous with annual litter-weight weaned (LWW) per ewe exposed to rams for breeding, and LWW is largely a function of number of lambs born (NLB) and weaned (NLW). Selecting for LWW should increase litter size and numbers of ewe-ram co-twins. Thus, we used historical records to...

  18. Parasitosis gastrointestinal and hematocrit value in ewe fed with different levels of crude protein

    Directory of Open Access Journals (Sweden)

    Francisco de Assis Fonseca de Macedo

    2015-12-01

    Full Text Available We evaluated the parasitological behavior of sheep females fed with different levels of crude protein, by the value of hematocrit and egg counts per gram of feces (EPG in identifying severely infected animals. Were used 47 female sheep of Santa Ines, Texel and Ile de France, aged between eight and 12 months, wormed 30 days before the first data of crops, which were held every two weeks. Within each race, the animals were divided into two treatments, deferred by 12% or 16%, crude protein in the diet. It is obtained, laboratory, the value of hematocrit of each animal and the amount of EPG. The value of hematocrit showed a variation (28.5 a 34.0 throughout the experimental period, arising from changes (800 a 5400 of EPG values. No differences were identified for EPG and hematocrit levels between 12 and 16% of PB. Diet recommendation with 12% crude protein, by inferring lower commercial cost in feed.

  19. Dinâmica folicular ovariana em ovelhas Santa Inês portadoras do polimorfismo FecGe do gene GDF-9

    OpenAIRE

    2014-01-01

    Este trabalho teve por objetivo o estudo da dinamica folicular ovariana do periodo interovulatorio em ovelhas nuliparas da raca Santa Ines portadoras do polimorfismo FecGE. Foram utilizadas 21 ovelhas previamente genotipadas para o polimorfismo FecGE por PCR-RFLP. Os animais foram divididos em tres grupos (n=7/grupo) de acordo com o genotipo relacionado a mutacao como segue: WW - selvagem nao mutante; EW - heterozigoto e; EE - homozigoto. A dinamica folicular foi acompanhada por ultrassom den...

  20. Biomarkers of Osteosarcoma, Chondrosarcoma, and Ewing Sarcoma

    Science.gov (United States)

    Evola, Francesco R.; Costarella, Luciano; Pavone, Vito; Caff, Giuseppe; Cannavò, Luca; Sessa, Andrea; Avondo, Sergio; Sessa, Giuseppe

    2017-01-01

    Osteosarcoma is the most frequent malignant bone neoplasm, followed by chondrosarcoma and Ewing sarcoma. The diagnosis of bone neoplasms is generally made through histological evaluation of a biopsy. Clinical and radiological features are also important in aiding diagnosis and to complete the staging of bone cancer. In addition to these, there are several non-specific serological or specific molecular markers for bone neoplasms. In bone tumors, molecular markers increase the accuracy of the diagnosis and assist in subtyping bone tumors. Here, we review these markers and discuss their role in the diagnosis and prognosis of the three most frequent malignant bone neoplasms, namely osteosarcoma, chondrosarcoma, and Ewing sarcoma. PMID:28439237

  1. Efficiency of different hormonal treatments for estrus synchronization in tropical Santa Inês sheep.

    Science.gov (United States)

    Texeira, Tarcísio Alves; da Fonseca, Jeferson Ferreira; de Souza-Fabjan, Joanna Maria Gonçalves; de Rezende Carvalheira, Luciano; de Moura Fernandes, Daniel Andrews; Brandão, Felipe Zandonadi

    2016-03-01

    The aim of this study was to evaluate the effect of (i) the duration of hormone treatment with progestogen sponges during the seasonal anestrus and (ii) the administration of two doses of prostaglandin at 7 days apart during the breeding season on reproductive parameters of Santa Inês ewes. In experiment 1, 32 ewes received intravaginal MAP sponges for 6 (G6 days), 9 (G9 days), or 12 (G12days) days and 75 μg D-cloprostenol i.m. and 300 IU eCG i.m. 1 day before sponge removal. In experiment 2, 23 ewes received two doses of 0.48-mg sodium cloprostenol i.m. 7 days apart. Ovarian follicular dynamic was assessed through transrectal ultrasonography. Blood samples were collected daily to determine progesterone concentrations. In experiment 1, estrus and ovulation rates did not differ (P > 0.05) among protocols and between cyclic and acyclic ewes at the beginning of the experiment. The G9 days treatment showed a lower dispersion of ovulations in relation to onset of estrus when compared to G6 days and G12 days. In experiment 2, all ewes exhibit estrus and ovulated after the second dose of prostaglandin, although ewes that were in diestrus at D0 showed subluteal concentrations of progesterone during the follicle development stage of the treatment. In conclusion, the use of progestogen device during 9 days promotes lower dispersion of ovulation when compared to its use for 6 or 12 days, and the protocol of two doses of prostaglandin 7 days apart synchronizes estrus efficiently but results in follicular development under low progesterone concentrations.

  2. Ilha de Santa Catarina

    OpenAIRE

    Nopes, Adriano

    2007-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Filosofia E Ciências Humanas. Programa de Pós-Graduação em Sociologia Política Este trabalho tem como foco de análise o processo de modernização na Praia dos Ingleses, um bairro atual situado no extremo norte da Ilha de Santa Catarina. Como referencial teórico da modernidade, utilizamos pensadores contemporâneos como Berman, Giddens e Habermas; para estes autores a modernização é compreendida como um fenômeno comple...

  3. Les apports nutritionnels conseillés (ANC en protéines

    Directory of Open Access Journals (Sweden)

    Patureau mirand Philippe

    2003-01-01

    Full Text Available La définition d’apports conseillés en protéines repose sur l’analyse des besoins protéiques. Un ANC avec comme objectif mesuré le maintien de la masse des protéines corporelles, a été fixé à 0,8 g de protéines de bonne qualité par kg de poids et par jour. Toutefois le besoin protéique est beaucoup plus complexe en raison de la diversité de la nature des nutriments requis pour le satisfaire (azote, acides aminés, peptides, protéines et de la multiplicité de leurs fonctions. L’ANC en protéines intègre en grande partie cette diversité et constitue un repère simple qui permet de s’assurer globalement de la couverture des besoins protéiques d’une large population. Sa simplicité en limite cependant la pertinence pour des sous-populations ayant des besoins plus spécifiques.

  4. Review of therapeutic strategies for osteosarcoma, chondrosarcoma, and Ewing?s sarcoma

    OpenAIRE

    Dai, Xing; MA, Wei; He, Xijing; Jha, Rajiv Kumar

    2011-01-01

    Summary The most prevalent forms of bone cancer are osteosarcoma, chondrosarcoma, and Ewing?s sarcoma. Although chemotherapy and radiotherapy have replaced traditional surgical treatments, survival rates have undergone only marginal improvements. Current knowledge of the molecular pathways involved in each type of cancer has led to better approaches in cancer treatment. A number of cell signaling molecules are involved in tumorigenesis, and specific targets have been identified based on these...

  5. Extraosseus Ewing sarcoma: An uncommon periclavicular location

    Directory of Open Access Journals (Sweden)

    Fabrizio Albarello, MD

    2015-01-01

    Full Text Available A rapidly enlarging right sternoclavicular mass in a young male was labeled as a nonspecific mass. MRI played a crucial role in characterizing the lesion, helping to define the possible mesenchymal origin and the relative involvement of the surrounding structures. We also discuss the differential diagnosis of an extraosseus Ewing sarcoma (ES, with its imaging findings.

  6. Hypocalcemia in ewes after a drought

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, J.W.A.; Constable, P.D.; Napthine, D.V.

    1986-01-01

    A marked increase in the incidence of hypocalcemia of ewes 2 to 6 weeks before lambing was observed in the Western District of Victoria, following the break of the severe 1982/3 drought. A similar observation was made after the 1968 drought. In western Victoria, hypocalcemia is usually seen annually as sporadic cases or in sporadic outbreaks associated with some predisposing stress. After the drought broke in 1983, many farms reported cases of hypocalcemia in ewes. The incidence of hypocalcemia on the 9 farms the authors studied varied from 1 to 8% of all ewes, with some mobs having an incidence of over 10%. Detailed investigation of 9 farms that affected sheep were grazing pasture of unusually low calcium (Ca) content. Near record rains fell after the drought broke in late March 1983 resulting in luxuriant pasture growth with subterranean clover Trifolium subterraneum and capeweed Arctotheca calendula the dominant species. Cases of hypocalcemia commenced in May 1983 reaching a peak in June-July corresponding with flocks' lambing times, and continued into August. Most occurred spontaneously in mature ewes. A few farms experienced many cases during prelambing crutching.

  7. The Santa Ana Partnership

    Science.gov (United States)

    Cournoyer, David, Ed.

    2004-01-01

    One of the priority interests of the W.K. Kellogg Foundation is to connect the knowledge and resources of institutions with communities in order to improve the quality of life in community. Partnerships achieve uncommon results. In Santa Ana, California, an unusual partnership of public schools, community college, universities, community…

  8. From Nanostructure to Nano Biosensor: Institute of Nano Electronic Engineering (INEE, UniMAP Experience

    Directory of Open Access Journals (Sweden)

    U Hashim

    2012-02-01

    Full Text Available Nanostructure is defined as something that has a physical dimension smaller than 100 nanometers, ranging from clusters and/or to dimensional layers of atoms. There are three most important nanostructures that are extensively studied and researched in various organizations including Institute of Nano Electronic Engineering (INEE in UniMAP. These include quantum dot, nanowire, and nanogap, which have been successfully designed and fabricated using in-house facilities available. These are subsequently used as a main sensing component in nanostructures based biosensor. This fabrication, characterization and testing job were done within four main interlinked laboratories namely microfabrication cleanroom, nanofabrication cleanroom, failure analysis laboratory and nano biochip laboratory.  Currently, development of Nano Biosensor is the main research focus in INEE. In principle, biosensor is an analytical device which converts a biological response into an electrical signal.   Keywords: Nanostructure, INEE , nanowire , nanogap and Nano Biosensor

  9. Low pasture allowance until late gestation in ewes: behavioural and physiological changes in ewes and lambs from lambing to weaning.

    Science.gov (United States)

    Freitas-de-Melo, A; Ungerfeld, R; Hötzel, M J; Orihuela, A; Pérez-Clariget, R

    2017-02-01

    Low pasture allowance during gestation affects ewes' BW at parturition, the bond with their lamb, lamb development, and thus also may affect their responses to weaning. The objectives were to determine if native pasture allowance from before conception until late pregnancy affects ewe-lamb behaviours at lambing, ewes' milk yield, lambs' BW, and the behavioural and physiological changes of ewes and lambs at weaning. From 23 days before conception until 122 days of pregnancy, 24 ewes grazed on two different native pasture allowances: high (10 to 12 kg of dry matter (DM)/100 kg of BW per day; HPA treatment; n=12) or low (5 to 8 kg of DM/100 kg of BW per day; LPA treatment; n=12). Thereafter, all ewes grazed on Festuca arundinacea and received rice bran and crude glycerine. Ewes' body condition score (BCS) and BW were recorded during pregnancy and postpartum periods. Milk yield was determined on days 32, 41 and 54 after lambing. Lambs' BW was recorded from birth until 72 days after lambing. Latency from parturition until the ewe licked her lamb, maternal behaviour score (a test that evaluates maternal attachment to the lamb) and latency for lamb to stand up and suckle were determined. The behaviour of the lambs and ewes was recorded before and after weaning (at 65 days). The ewes' serum total protein, albumin and globulin concentrations were measured before and after weaning. The HPA ewes presented greater BW (Plate pregnancy, this did not affect the behaviours that lead to the establishment of the mother-young bond, nor the ewes' behavioural responses at weaning. Lambs reared by ewes that grazed on low pasture allowance during pregnancy presented fewer behavioural changes and a lower decrease of albumin concentration after weaning. Lambs' BW was not affected by the feeding received by their mothers.

  10. Cabozantinib-s-malate in Treating Patients With Relapsed Osteosarcoma or Ewing Sarcoma

    Science.gov (United States)

    2017-09-04

    Metastatic Ewing Sarcoma; Metastatic Osteosarcoma; Recurrent Ewing Sarcoma; Recurrent Osteosarcoma; Stage III Osteosarcoma AJCC v7; Stage IV Osteosarcoma AJCC v7; Stage IVA Osteosarcoma AJCC v7; Stage IVB Osteosarcoma AJCC v7; Unresectable Ewing Sarcoma; Unresectable Osteosarcoma

  11. Santa and the moon

    CERN Document Server

    Barthel, Peter

    2011-01-01

    Happy end-of-the-year evening and night events provide good opportunities to explain the phases of the moon. The need for such moon phase education is once again demonstrated, through an investigation of illustrations on Santa Claus and Christmas gift wrap and in children's books, in two countries which have been important in shaping the image of Santa Claus and his predecessor Sinterklaas: The Netherlands and the USA. The moon on Halloween illustrations is also considered. The lack of knowledge concerning the physical origin of the moon phases, or lack of interest in understanding, is found to be widespread in The Netherlands but is also clearly present in the USA, and is quite possibly global. Definitely incomplete, but surely representative lists compiling both scientifically correct and scientifically incorrect gift wrap and children's books are also presented.

  12. Energy and protein nutrition of ewes in late pregnancy

    OpenAIRE

    Hallfríður Ósk Ólafsdóttir 1978

    2012-01-01

    Feeding of the pregnant ewe affects its weight and condition and subsequently the ability to supply the lambs with adequate nutrition. Supplementing is commonly used to secure adequate birth weight and growth rate but for efficient use the condition of the ewes as well as total composition of the diet has to be considered thoroughly. In the experiment described here the effect of feeding different concentrates during the last month prepartum on ewe and lambs health and performa...

  13. INES 2000 ja Läänemere ülikool / Annika Tenno

    Index Scriptorium Estoniae

    Tenno, Annika

    2000-01-01

    Läänemere Ülikooli programmiga (The Baltic University Programme) seotud õppejõududel oli võimalus osaleda INES 2000 konverentsil Stockholmis 14.-18. juunil̀2000, peateemaks "Challenges for Science and Engineering in the 21st Century". Tallinna Pedagoogikaülikooli esindajaks oli Tiina Elvisto

  14. The De-Genderization of Knowledge Production: The Case of Sor Juana Ines de la Cruz.

    Science.gov (United States)

    Salazar, Norma

    1994-01-01

    All societies have official knowledge. Life of Sor Juana Ines de la Cruz, 17th-century nun and literary genius, illustrates who discovers knowledge is more important than what knowledge is promulgated. Real issue was not what Sor Juana wrote but whether nun or woman should engage in producing and publishing knowledge. Her efforts have inspired…

  15. INES 2000 ja Läänemere ülikool / Annika Tenno

    Index Scriptorium Estoniae

    Tenno, Annika

    2000-01-01

    Läänemere Ülikooli programmiga (The Baltic University Programme) seotud õppejõududel oli võimalus osaleda INES 2000 konverentsil Stockholmis 14.-18. juunil̀2000, peateemaks "Challenges for Science and Engineering in the 21st Century". Tallinna Pedagoogikaülikooli esindajaks oli Tiina Elvisto

  16. Ewing Sarcoma of the Posterior Fossa in an Adolescent Girl

    Directory of Open Access Journals (Sweden)

    Andreas M. Stark

    2014-01-01

    Full Text Available Medulloblastoma, astrocytoma, and ependymoma represent the most common infratentorial tumors in childhood, while Ewing sarcomas in that localization are extremely rare. A large left infratentorial space-occupying lesion was diagnosed in a 12-year-old girl with signs of increased intracranial pressure. Following total tumor resection, histological and molecular examination revealed Ewing sarcoma with rearranged EWSR-1 gene. The patient achieved complete remission following adjuvant chemotherapy and radiotherapy according to Euro-EWING 2008 treatment protocol. Intracranial Ewing sarcoma, although rare, should be an important differential diagnosis of intracranial tumors in childhood which requires aggressive multimodal treatment.

  17. Biomarkers of Osteosarcoma, Chondrosarcoma, and Ewing Sarcoma

    OpenAIRE

    Evola, Francesco R.; Costarella, Luciano; Pavone, Vito; Caff, Giuseppe; Cannavò, Luca; Sessa, Andrea; Avondo, Sergio; Sessa, Giuseppe

    2017-01-01

    Osteosarcoma is the most frequent malignant bone neoplasm, followed by chondrosarcoma and Ewing sarcoma. The diagnosis of bone neoplasms is generally made through histological evaluation of a biopsy. Clinical and radiological features are also important in aiding diagnosis and to complete the staging of bone cancer. In addition to these, there are several non-specific serological or specific molecular markers for bone neoplasms. In bone tumors, molecular markers increase the accuracy of the d...

  18. At slaughtering and post mortem characteristics on Traditional market ewes and Halal market ewes in Tuscany.

    Science.gov (United States)

    Sargentini, Clara; Tocci, Roberto; Campostrini, Matteo; Pippi, Eleonora; Iaconisi, Valeria

    2016-01-01

    The aim of this work was the comparison between the carcass and the meat ewes of the regional Traditional market and the Islamic religious (Halal) market. Thirty and 20 at the end of career traditional market and Halal market ewes were slaughtered following the EC (European Council, 2009) animal welfare guidelines. Live weight of ewes was taken and dressing percentage of carcasses was calculated. On every carcass zoometric measurement and the evaluation trough the EU grid rules were performed. On the Musculus longissimus thoracis of 12 Traditional market carcasses and 11 Halal market carcasses the physical-chemical and nutritional analysis were performed. Consumer tests for liking meat ewe were performed in order to find consumer's preference level for Traditional and Halal markets ewe meat. Considering as fixed factor the ewe meat market (Traditional and Halal), results were submitted to oneway Analysis of Variance (ANOVA) and to Principal Component Analysis (PCA). The Halal market ewes have shown lower dressing percentages (42.91 ± 0.82 vs 46.42 ± 0.69) and lower conformation score (4.5 ± 0.5 vs 7.8 ± 0.4). The Halal market meat showed higher cooking loss in oven (37.83 ± 1.20 vs 32.03 ± 1.15 %), lesser Chroma value (18.63 ± 0.70 vs 21.84 ± 0.67), and lesser Hue angle value (0.26 ± 0.02 vs 0.34 ± 0.02). This product had also lower fat percentage (4.2 ± 0.4 vs 7.09 ± 0.4). The traditional market meat had higher percentage in monounsatured fatty acids (MUFA) (43.84 ± 1.05 vs 38.22 ± 1.10), while the Halal market meat had higher percentage in ω3 poliunsatured fatty acids (PUFA) (5.04 ± 0.42 vs 3.60 ± 0.40). The consumer test showed as the ewe meat was appreciate by the consumers. Both meat typologies have shown good nutritional characteristics. The traditional market meat had higher MUFA composition, and a better MUFA/satured fatty acids (SFA) ratio, while the Halal market meat had

  19. Evaluation of operational incidents in the research reactor RP-10 according to scale INES; Evaluacion de incidentes operacionales en el reactor de investigacion RP-10 segun escala INES

    Energy Technology Data Exchange (ETDEWEB)

    Arrieta, Rolando W.B.; Vela Mora, Mariano, E-mail: rarrieta@ipen.gob.pe, E-mail: mvela@ipen.gob.pe [Instituto Peruano de energia Nuclear, Lima (Peru). Dept. de Operacion de Reactores

    2013-07-01

    This report presents the evaluation of the events in 2011 in the RP-10 Nuclear Reactor Nuclear Center Huarangal from the point of view of safety. To classify these events produced is used Scale International Nuclear and Radiological Event Scale (INES) to facilitate a common understanding between the technical community, the media and the general public. From the results we can say that in 2011 all related to security events that occurred in the RP -10 are classified as 'below scale' or no safety significance. (author)

  20. Colostrum composition of Santa Inês sheep and passive transfer of immunity to lambs.

    Science.gov (United States)

    Alves, A C; Alves, N G; Ascari, I J; Junqueira, F B; Coutinho, A S; Lima, R R; Pérez, J R O; De Paula, S O; Furusho-Garcia, I F; Abreu, L R

    2015-06-01

    This study aimed to analyze the chemical composition and the IgG concentration of the colostrum, transitional milk, and mature milk of Santa Inês ewes as well as the transfer of passive immunity to lambs. Thirty-two pregnant ewes and 38 lambs were used. Ewes were milked immediately after lambing and at 12, 24, 36 h and 10 d postpartum. Colostrum was provided to the lambs at 40±15 min (mean±SE) after birth and then at 30-min intervals for obtaining the intake closest to 10% of body weight, and transitional milk was provided ad libitum. Blood from the lambs was collected 36 h after birth for measuring the serum concentrations of IgG, total protein, albumin, and gamma-globulin. The production was lower in primiparous than in multiparous ewes with body condition score (BCS)colostrum was higher in ewes with BCScolostrum was not correlated with the ewe's weight or BCS at the time of lambing. Moreover, the parity, the BCS, the ewe's type of gestation, and the lamb's sex did not influence the serum concentrations of IgG, total protein, albumin, and gamma-globulin in lambs. Adequate passive immune transfer (PIT) was observed in lambs for which the IgG intake was higher than 30 g. Failure in PIT was observed in 39.5% of lambs when considering a serum IgG concentration lower than 15 mg/mL and in 21% when considering a serum total protein concentration lower than 45 mg/mL. The mean apparent efficiency of absorption was 38.10%, with values between 0.02% and 98.80%. The serum IgG concentration was correlated with the total protein concentration (according to the enzymatic colorimetric method), the gamma-globulin concentration, and the absorption efficiency. The extreme variation on apparent efficiency of absorption may have an effect on the success of PIT. Lambs should consume at least 30 g of IgG in the first 24 h of life to ensure adequate PIT.

  1. Is There a Predisposition Gene for Ewing's Sarcoma?

    Directory of Open Access Journals (Sweden)

    R. L. Randall

    2010-01-01

    Full Text Available Ewing's sarcoma is a highly malignant tumor of children and young adults. The molecular mechanisms that underlie Ewing's Sarcoma development are beginning to be understood. For example, most cases of this disease harbor somatic chromosomal translocations that fuse the EWSR1 gene on chromosome 22 with members of the ETS family. While some cooperative genetic events have been identified, such as mutations in TP53 or deletions of the CDKN2A locus, these appear to be absent in the vast majority of cases. It is therefore uncertain whether EWS/ETS translocations are the only consistently present alteration in this tumor, or whether there are other recurrent abnormalities yet to be discovered. One method to discover such mutations is to identify familial cases of Ewing's sarcoma and to then map the susceptibility locus using traditional genetic mapping techniques. Although cases of sibling pairs with Ewing's sarcoma exist, familial cases of Ewing's sarcoma have not been reported. While Ewing's sarcoma has been reported as a 2nd malignancy after retinoblastoma, significant associations of Ewing's sarcoma with classic tumor susceptibility syndromes have not been identified. We will review the current evidence, or lack thereof, regarding the potential of a heritable condition predisposing to Ewing's sarcoma.

  2. Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma

    Science.gov (United States)

    2017-02-08

    Adult Supratentorial Primitive Neuroectodermal Tumor (PNET); Childhood Supratentorial Primitive Neuroectodermal Tumor; Ewing Sarcoma of Bone; Extraosseous Ewing Sarcoma; Extraosseous Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Peripheral Primitive Neuroectodermal Tumor of the Kidney; Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor

  3. Effect of propolis on ruminal fermentation, reproductive and productive performance of Santa Inês ewes

    OpenAIRE

    Amr Salah Morsy Amine Selem

    2012-01-01

    Propolis as natural dietary additive can be used to manipulate rumen fermentation towards less methane (CH4) and it may affect animal reproductive and productive performance. To study the application of propolis, three studies were conducted. The first study aimed to evaluate the in vitro nutritive value of two types of propolis (Brazilian red propolis (BRP) and Egyptian brown propolis (EBP) for their anti-methanogenic activity, ruminal fermentation and degradability. Propolis extracts were p...

  4. Kulinaarne palverännak piki Telliskivi tänavat / Martin Hanson, Ines Haak

    Index Scriptorium Estoniae

    Hanson, Martin, 1984-

    2013-01-01

    Toidukriitik Martin Hanson ja sisearhitekt Ines Haak Tallinna Telliskivi tänavat palistavatest söögipaikadest: restoran Kolm Sibulat (sisearhitektuur: Aivar Mühlbach, omanikud, 2012-2013), bistroo Kukeke (Anni Arro, Riina Eerik, 2011-2012), kohvik Reval (Ville Lausmäe, Kadi Karmann, Peeter Klaas, 2013), restoran F-Hoone (Ville Jehe, Steve Heinlo, 2010), baar Pudel (Raul Tiitus, Tarmo Piirmets, 2012-2013)

  5. FOXM1 is an oncogenic mediator in Ewing Sarcoma.

    Directory of Open Access Journals (Sweden)

    Laura Christensen

    Full Text Available Ewing Family Tumors (Ewing Sarcoma and peripheral Primitive Neuroectodermal Tumor are common bone and soft tissue malignancies of childhood, adolescence and young adulthood. Chromosomal translocation in these tumors produces fusion oncogenes of the EWS/ETS class, with EWS/FLI1 being by far the most common. EWS/ETS chimera are the only well established driver mutations in these tumors and they function as aberrant transcription factors. Understanding the downstream genes whose expression is modified has been a central approach to the study of these tumors. FOXM1 is a proliferation associated transcription factor which has increasingly been found to play a role in the pathogenesis of a wide range of human cancers. Here we demonstrate that FOXM1 is expressed in Ewing primary tumors and cell lines. Reduction in FOXM1 expression in Ewing cell lines results in diminished potential for anchorage independent growth. FOXM1 expression is enhanced by EWS/FLI1, though, unlike other tumor systems, it is not driven by expression of the EWS/FLI1 target GLI1. Thiostrepton is a compound known to inhibit FOXM1 by direct binding. We show that Thiostrepton diminishes FOXM1 expression in Ewing cell lines and this reduction reduces cell viability through an apoptotic mechanism. FOXM1 is involved in Ewing tumor pathogenesis and may prove to be a useful therapeutic target in Ewing tumors.

  6. Ewing sarcoma versus osteomyelitis: differential diagnosis with magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Henninger, B.; Glodny, B.; Rudisch, A.; Trieb, T.; Loizides, A.; Judmaier, W.; Schocke, M.F. [Innsbruck Medical University, Department of Radiology, Innsbruck (Austria); Putzer, D. [Innsbruck Medical University, Department of Nuclear Medicine, Innsbruck (Austria)

    2013-08-15

    To find and evaluate characteristic magnetic resonance imaging (MRI) patterns for the differentiation between Ewing sarcoma and osteomyelitis. We identified 28 consecutive patients referred to our department for MRI (1.5 T) of an unclear bone lesion with clinical symptoms suggestive of Ewing sarcoma or osteomyelitis. MRI scans were re-evaluated by two experienced radiologists, typical MR imaging features were documented and a diagnostic decision between Ewing sarcoma and osteomyelitis was made. Statistical significance of the association between MRI features and the biopsy-based diagnosis was assessed using Fisher's exact test. The most clear-cut pattern for determining the correct diagnosis was the presence of a sharp and defined margin of the bone lesion, which was found in all patients with Ewing sarcoma, but in none of the patients with osteomyelitis (P < 0.0001). Contrast enhancing soft tissue was present in all cases with Ewing sarcoma and absent in 4 patients with osteomyelitis (P = 0.0103). Cortical destruction was found in all patients with Ewing sarcoma, 4 patients with osteomyelitis did not present any cortical reaction (P = 0.0103). Cystic or necrotic areas were identified in 13 patients with Ewing sarcoma and in 1 patient with osteomyelitis (P = 0.004). Interobserver reliability was very good (kappa = 1) in Ewing sarcoma and moderate (kappa = 0.6) in patients with osteomyelitis. A sharp and defined margin, optimally visualized on T1-weighted images in comparison to short tau inversion recovery (STIR) images, is the most significant feature of Ewing sarcoma in differentiating from osteomyelitis. (orig.)

  7. Sacral Ewing's Sarcoma and Challenges in it's Diagnosis on MRI

    Directory of Open Access Journals (Sweden)

    Albert D'Souza

    2009-01-01

    Full Text Available A 15-yr old boy presented with low backache for 4 months associated with weakness of left lower limb. MRI of lumbosacral spine showed a sacral lesion with intraspinal and presacral soft tissue extension with neural compression. A diagnosis of tuberculosis was considered in the view of high prevalence in this part of the world, however biopsy revealed Ewing's sarcoma. Ewing's tumor of sacrum is rare, but should be suspected in low backache in children. Differential diagnosis for a sacral lesion includes tuberculosis, pyogenic osteomyelitis, lymphoma, chordoma, osteosarcoma and Ewing's sarcoma. MRI is sensitive in detecting these lesions but is nonspecific requiring histopathological examination for confirmation.

  8. Primary Establishment of EWE Model in Caohai Nature Reserve

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    According to environmental data,Ecopath with Ecosim (EWE) model can quantitatively describe the energy flow in the production and consumption of function components of system by using trophodynamics,and accurately assess the biomass and stable state of aquatic ecosystem.In the paper,the basic principle and parameters of EWE model were introduced firstly,and the relationship between Q/B (the important parameter of EWE model) and basic life indices of fish was discussed,then the current study and typical r...

  9. Microbiological studies on genital infections in slaughtered ewes ...

    African Journals Online (AJOL)

    ADEYEYE

    2014-01-15

    Jan 15, 2014 ... Faculty of Veterinary Medicine, University of Maiduguri, Borno State-Nigeria. 2. Federal Medical .... clinical parameters with reproductive history of live animals would have .... on natural and experimental endometritis in ewes.

  10. Santa Maria Volcano, Guatemala

    Science.gov (United States)

    2002-01-01

    The eruption of Santa Maria volcano in 1902 was one of the largest eruptions of the 20th century, forming a large crater on the mountain's southwest flank. Since 1922, a lava-dome complex, Santiaguito, has been forming in the 1902 crater. Growth of the dome has produced pyroclastic flows as recently as the 2001-they can be identified in this image. The city of Quezaltenango (approximately 90,000 people in 1989) sits below the 3772 m summit. The volcano is considered dangerous because of the possibility of a dome collapse such as one that occurred in 1929, which killed about 5000 people. A second hazard results from the flow of volcanic debris into rivers south of Santiaguito, which can lead to catastrophic flooding and mud flows. More information on this volcano can be found at web sites maintained by the Smithsonian Institution, Volcano World, and Michigan Tech University. ISS004-ESC-7999 was taken 17 February 2002 from the International Space Station using a digital camera. The image is provided by the Earth Sciences and Image Analysis Laboratory at Johnson Space Center. Searching and viewing of additional images taken by astronauts and cosmonauts is available at the NASA-JSC Gateway to

  11. ciudad de Santa Marta

    Directory of Open Access Journals (Sweden)

    Javier Alfredo Ferreira Ospino

    2008-01-01

    Full Text Available Esta investigación evalúa los resultados de un programa de Formación en Derechos con madres comunitarias para la solución de conflictos en la Comuna Ocho de la ciudad de Santa Marta. El programa buscó el desarrollo de la capacidad de análisis y discernimiento para la toma de decisiones, que les permitan participar activamente en la solución de problemas de la comunidad, tendientes a mejorar las condiciones de vida de los miembros de la ésta. El proyecto se enmarca en un diseño de investigación cuasiexperimental con grupo control y medida pre y post, de forma que puedan medirse no sólo los resultados del programa, sino su efectividad para la resolución de conflictos en la comunidad. Se utilizó el cuestionario adaptado a la Teoría de Rahim y otros autores de la teoría del conflicto con el fin de determinar la manera como se resuelven los conflictos en la comunidad. Esta investigación se centró en demostrar objetivamente la efectividad del programa y las diferencias deliberativas y discursivas más relevantes entre los sujetos que recibieron formación en derechos.

  12. Primary extraosseous Ewing sarcoma of the orbit.

    Science.gov (United States)

    Alio, Jorge L; Sales-Sanz, Marco; Vaz, Maria A; Barrancos, Constanza; Reguero, Maria E; Diamantopoulus, Jorge; Poveda, Pedro

    2013-01-01

    A 40-year-old man presented with painless, progressive vision loss and mild proptosis of the OD. CT revealed a right intraconal mass with slight penetration of the optic canal not contiguous with any bony structure. Incisional biopsy through a transfrontal orbitotomy revealed a diffuse growth of homogeneous, small, round cells. Immunohistochemical stains were positive for vimentin and MIC2 (CD99), and the translocation at EWS gene (22q12) was detected. Metastatic workup and a full-body bone scan were negative, confirming primary orbital extraosseous Ewing sarcoma. The patient received neoadjuvant chemotherapy and an orbital exenteration with preservation of eyelids and conjunctiva. He also received adjuvant chemotherapy and local radiotherapy, and he has remained disease-free for almost 3 years.

  13. TEMA 2-2014: SARCOMA DE EWING

    OpenAIRE

    Jiménez Soto, Daniela; Soto Fallas, Javier; Garro Ortiz, Mario; Vega Ulate, Gustavo

    2014-01-01

    El grupo de tumores conocido como sarcoma de Ewing consiste en neoplasias de células redondas, morfológicamente similares y por la presencia de una translocación cromosómica común. Aunque poco frecuentes, estos tumores constituyen el tercer grupo de tumores primarios de hueso, después del osteosarcoma y el condrosarcoma. Afecta con mayor frecuencia a niños y adolescentes. Algunos casos presentan metástasis, con afección sistémica. El tratamiento se da con múltiples fármacos, así como el contr...

  14. Undernutrition affects embryo quality of superovulated ewes.

    Science.gov (United States)

    Abecia, J A; Forcada, F; Palacín, I; Sánchez-Prieto, L; Sosa, C; Fernández-Foren, A; Meikle, A

    2015-02-01

    To determine the effect of undernutrition on embryo production and quality in superovulated sheep, 45 ewes were allocated into two groups to be fed diets that provided 1.5 (control, C; n = 20) or 0.5 (low nutrition, L; n = 25) times daily requirements for maintenance, from oestrous synchronization with intravaginal sponges to embryo collection. Embryos were collected 7 days after the onset of oestrus (day 0). Low nutrition resulted in lower live weight and body condition at embryo collection (P < 0.05). Diet (P < 0.01) and day of sampling (P < 0.001) significantly affected plasma non-esterified fatty acid (NEFA) and insulin concentrations. Plasma leptin concentrations decreased on day 7 only in L ewes. A significant effect of dietary treatment (P < 0.05) and day (P < 0.0001) was observed on plasma insulin-like growth factor (IGF)-I concentrations. The number of recovered oocytes and embryos did not differ between the groups (L: 15.4 ± 0.4; C: 12.4 ± 0.4). Recovery rate was lower (P < 0.05) in the L (60%) than in the C group (73%). The total number of embryos and number of viable-transferable embryos (5.0 ± 0.3 and 3.4 ± 0.3 embryos, respectively) of the L group were lower (P < 0.1) when compared with controls (8.4 ± 0.4 and 6.2 ± 0.4 embryos, respectively). Undernutrition during the period of superovulation and early embryonic development reduced total and viable number of embryos. These effects might be mediated by disruption of endocrine homeostasis, oviduct environment and/or oocyte quality.

  15. Multiple trait genetic evaluation of ewe traits in Icelandic sheep.

    Science.gov (United States)

    Arnason, T; Jónmundsson, J V

    2008-12-01

    The prolificacy of the ewes was measured as the number of lambs born per ewe mated (NLB) when the ewes were 1-4 years of age. The ewe productivity related to the same age interval was measured by special ewe production indices (EPI). The genetic parameters for these traits were estimated by a series of bivariate REML analyses using animal models. The material used for the genetic analysis contained records on 193,213 ewes. The heritability estimates for NLB were h(2) = 0.17, 0.13, 0.11, 0.10 for the four respective age classes. Corresponding estimates for EPI were h(2) = 0.16, 0.17, 0.17, 0.15. The genetic correlations among NLB at different ages ranged from 0.63 to 0.98 and among EPI from 0.82 to 0.99. The genetic correlations between NLB and EPI were generally low. The material used for estimating the breeding values by the MT-BLUP Animal Model consisted of 1.5 million individuals in the pedigree file. In total 815,782 ewes had records for the NLB and 763,491 ewes had production index (at least 1 year). The records were registered in the years 1990-2006. All possible missing patterns were present in the data. In the iteration process expected values for missing traits were generated and solutions were obtained on canonical transformed scale. The genetic evaluations were run independently for NLB and EPI for computational convenience given the correlations between these traits were negligible.

  16. Lipid requirements in the nutrition of dairy ewes

    Directory of Open Access Journals (Sweden)

    Andrea Serra

    2010-01-01

    Full Text Available The aim of this review was to contribute to the knowledge of lipid requirements in dairy ewes, by reviewing experi- mental papers about lipid supplementation in dairy ewe feeding. The number of trials in ewe feeding is lower than that in dairy cow feeding and, leaving calcium soap of palm oil out of consideration, there is a lack of knowledge regarding the effects of protected and unprotected lipid sources on milk yield and quality from dairy ewes. On the basis of data reported in the literature, the optimal dose of calcium soap of palm oil resulted to be 100-120 g/d. Also, milk fatty acid composition may be improved by adding calcium soap of fatty acids to ewe diets. The general effect of calcium salt sup- plementation is an increase in milk unsaturated fatty acids and a decrease in saturated ones. However, more research is needed in order to explain the effect of different fat sources (protected and unprotected on milk yield and quality from dairy ewes.

  17. Effect of ewe prolificacy potential and stocking rate on ewe and lamb performance in a grass-based lamb production system.

    Science.gov (United States)

    Earle, E; McHugh, N; Boland, T M; Creighton, P

    2017-01-01

    The objective of the present study was to investigate the effect of ewe prolificacy potential (PP; predicted number of lambs born per ewe per year) as dictated by sire breed type, stocking rate (SR; ewes per ha), and their interaction on ewe and lamb performance in a temperate grass-based lamb production system. The study was a 2 × 3 factorial design, consisting of 2 differing ewe PP and 3 SR which included 180 medium prolificacy potential (MP- Suffolk-sired crossbred ewes) and 180 high prolificacy potential ewes (HP- Belclare-sired crossbred ewes) allocated to 1 of 3 ( = 60 ewes) SR: low (LSR; 10 ewes per ha), medium (MSR; 12 ewes per ha) or high (HSR: 14 ewes per ha). Each treatment was managed in a 5-paddock rotational grazing system for the duration of the study. Medium prolificacy ewes were consistently heavier ( < 0.001) compared to HP ewes, with HP ewes having a higher BCS at lambing and 6 wk post-lambing (PL; < 0.05). Low SR ewes had a higher BW ( < 0.05) and BCS ( < 0.05) at mating, 6 wk PL, and weaning relative to MSR and HSR ewes which did not differ from each other. Lambs born to MP ewes were heavier at birth and weaning ( < 0.001) and achieved a higher ADG from birth to weaning ( < 0.05). Ewe PP had no effect on lifetime ADG or d to slaughter (DTS) with HP lambs yielding a higher carcass weight ( < 0.001). Low SR and MSR lambs achieved higher ADG from birth to weaning ( < 0.001) and weaning weight ( < 0.001) relative to HSR lambs and did not differ from each other, while post-weaning and lifetime lamb ADG was highest at the LSR, intermediate at the MSR, and lowest at the HSR ( < 0.001). A ewe PP by SR interaction existed for DTS, with MP lambs at the LSR reaching slaughter weight earlier ( < 0.01) relative to HP lambs, while at the MSR and HSR, MP and HP lambs did not differ from each other. High PP ewes produced a higher average born ( < 0.001) and weaned litter size per ewe ( < 0.01), with live weight weaned per ha ( < 0.001) increasing as ewe PP

  18. Određivanje čistoće površine metalnih i keramičkih uzoraka

    OpenAIRE

    Štrakalj, Anita; Glavaš, Zoran; Sladojević, Milan

    2012-01-01

    U ovom radu određivana je čistoća površine metalnih i keramičkih uzoraka. Uzorci su pripremljeni mehaničkim i kemijskim čišćenjem. Čistoća površine određena je statičkom ekstrakcijskom metodom. Statička ekstrakcijska metoda pokazala se kao izuzetno dobra metoda za mjerenje čistoće površine. Dobiveni rezultati ukazuju da su oba korištena načina pripreme uzoraka u skladu s normom MIL-P-28809. Nešto bolji rezultati dobiveni su prilikom kemijskog čišćenja uzoraka.

  19. Sound speed in air-filled sand and 03ine shallow-layer sandy sediments

    Institute of Scientific and Technical Information of China (English)

    QIAN Zuwen

    2009-01-01

    Based on the author's theory for acoustic propagation in granular media and by employing the extinction theorem, the sound speed formulae in these media were derived. The numerical computations of sound speed in 03ine sediments and air-filled sand were carried out, and the results demonstrated that under the normal atmosphere the sound speed in air- filled sand is lower than the sound speed in the air. The numerical results also indicated that the influence of scattering interaction between the grains upon the sound speed in the 03ine shallow-layer sandy sediments has to be taken into account; however, the influence of the viscous-wave interaction can be neglected. The theoretical results obtained from the rigid-granular model seem to match the measured data better than from the elastic-granular model, even the latter model fits better for the real situation, indicating further measurements are necessary in order to gain an insight into this problem thoroughly. Through an analysis of experimental data published in journals a conclusion can be drawn that the theory of granular media is suited to deal with the problems of the sound propagation in air-filled sand better than the theory of porous media.

  20. Santa Claus ’Names

    Institute of Scientific and Technical Information of China (English)

    寒冰

    2005-01-01

    A ustria—Christkind Belgium and the N etherlands—N oel Saint Nicholas C hristkind and Black Pete Brazil—Papa;N oel D enm ark—Julinisse England—Father Christm as Finland—O ld M an C hristm asFrance—Pere N oel or le Petit Germ any—K riss Kringle Christkind or Saint N icholas Italy—B efana Japan—Santa K urohsu M exico—Three Kings Poland—Star M an or W ise M en Spain—Three Kings R ussia—B asbouschka ?Santa Claus ’Names@寒冰

  1. Dietary energy in late pregnancy and during lactation and performance of Santa Inês sheep in an accelerated mating system

    Directory of Open Access Journals (Sweden)

    Filipe Alexandre Boscaro Castro

    2014-02-01

    Full Text Available The objective of this study was to evaluate feed energy concentration in the last third of pregnancy and during lactation of ewe in an accelerated mating system. Three rations with different energy content were evaluated: 2.0; 2.2 and 2.4 Mcal of ME/kg DM, which were randomly distributed to the animals. Experimental rations were fed to animals in the last third of pregnancy and lactation for three consecutive productive cycles. Before start each period of provision of the rations, only females gestating one lamb were selected from a flock of 50 animals, being utilized 18; 19 and 18 ewes in the first, second and third cycle, respectively. At the beginning of each experimental period, ewes were at 105 days of gestation with an average body weight of 52.00 kg and average body condition score of 3.00. Newborn lambs remained with their mothers until weaning, at 60 days of age. After weaning, all ewes were managed on pasture, being supplemented daily with sorghum silage and concentrate based on corn and soybean meal. It was aimed the reduction of lambing interval through the reproductive management. From the beginning of the provision of the rations until weaning there was a linear increase in body weight and body condition of the ewes, as energy concentration increased. It was also verified a positive linear effect of energy content on weight of lambs from birth to weaning, and on average daily weight gain (0.125; 0.176 and 0.220 kg, for 2.0; 2.2 and 2.4, respectively. Females fed with 2.0 Mcal of ME/kg of DM presented the worst indices for lambing rate (66.7; 100.0 and 83.3%, birth rate (72.2; 105.3 and 88.9% and service period (131.1; 128.4 and 122.2 days, for 2.0, 2.2 and 2.4, respectively. The season of provision of rations did not affect any of the productive or reproductive parameters evaluated. Santa Inês ewes can be used for lamb production in an accelerated mating system, since the nutritional management of the herd is controlled in order

  2. Plasma Fatty Acid Profile of Gestating Ewes Supplemented with Fishmeal

    Directory of Open Access Journals (Sweden)

    Mamun M. Or-Rashid

    2012-01-01

    Full Text Available Problem statement: The very long chain n-3 polyunsaturated fatty acids (>18C cannot be adequately synthesized by ruminant tissues to meet their requirements; therefore, their concentration in body depends on the supply through feed. It may be possible to improve the essential fatty acid status of ruminant animals, during gestation by manipulating the maternal diet with Fishmeal (FM. The objectives of this research were to (1 determine the effect of fishmeal supplementation on the plasma fatty acid profile of ewes during late gestation and (2 determine the status of the plasma docosahexaenoic acid (22:6n3 of lambs born to these ewes. Approach: Eight gestating ewes [Rideau-Arcott, 97±5 kg initial body weight, 100 days of gestation] were used in a completely randomized design. Ewes were individually-housed and fed either a control diet (supplemented with soybean meal or a fishmeal supplemented diet. Blood samples were collected via jugular venipuncture for plasma fatty acids analysis on 100, 114, 128 and 142 days of “gestation”. Blood samples from the lambs were also collected via jugular venipuncture immediately after birth and before receiving their mothers’ colostrum. Plasma fatty acids were analyzed by gas-liquid chromatography. Results: The ewes from both groups, i.e., control and fishmeal supplemented, had a similar fatty acid profile prior to supplementation (at 100 days, p>0.05. Thereafter, there was an increase in eicosapentaenoic acid (20:5n3, docosahexaenoic acid, total n3-PUFA and total very long chain n3-PUFA (>C18 contents in plasma for the fishmeal supplemented ewes compared to the control (p0.05 in total saturated fatty acids, total monounsaturated fatty acids, total conjugated linoleic acid, total trans-18:1, total cis-18:1, or total n6-PUFA contents in ewe plasma between control and fishmeal supplemented groups. Lambs born to ewes fed the fishmeal supplemented diet had greater (pConclusion: The ewes supplemented

  3. Yeasts associated with Sardinian ewe's dairy products.

    Science.gov (United States)

    Cosentino, S; Fadda, M E; Deplano, M; Mulargia, A F; Palmas, F

    2001-09-19

    In the present work, the occurrence of yeasts in different types of typical Sardinian ewe's cheeses (32 samples of pecorino, 32 of caciotta, 40 of feta, 56 of ricotta) was determined. For the strains isolated the following properties were studied: proteolytic and lipolytic activities, the ability to grow at different temperatures, different concentrations of salt, and to assimilate and/or ferment compounds like lactate, citrate, lactose, glucose, galactose, lactic acid. Of 160 samples analysed, 76.2% yielded growth of yeasts. Yeast counts showed a certain variability among the samples. The highest levels were observed in caciotta and feta cheeses. A total of 281 strains belonging to 16 genera and 25 species were identified. In general, Debaryomyces hansenii was the dominant species, representing 28.8% of the total isolates. Other frequently appearing species were Geotrichum candidum, Kluyveromyces lactis and K. marxianus. Other genera encountered were Pichia, Candida, Dekkera, Yarrowia and Rhodotorula. With regard to the biochemical and technological properties of the yeasts, only K. lactis, K. marxianus and Dek. anomala assimilated and fermented lactose, whereas the majority of the species assimilated lactic acid. The assimilation of citrate was a characteristic of D. hansenii, R. rubra and Y. lipolytica. On the whole, the yeasts were weakly proteolytic while lipolytic activity was present in several species. A high percentage of strains showed a certain tolerance to low temperatures while only some strains of D. hansenii and K. lactis were able to grow at a 10% NaCl concentration.

  4. Ewing's sarcoma: an approach to radiological diagnosis.

    Science.gov (United States)

    Lombardi, F; Gasparini, M; Gianni, C; Petrillo, R; Tesoro-Tess, J D; Volterrani, F; Musumeci, R

    1979-06-30

    All the pertinent radiographs of 83 patients with histologically proven Ewing's sarcoma were reviewed. Forty-nine patients were in the pediatric age group, and 34 were adults. The mean age, the symptoms and time from symptoms to diagnosis were evaluated in the 2 groups. The site of primary involvement was in 54% the long bones, 35% the flat bones, 8% the small bones and 3% extraosseous. For the primary site we considered the diagnostic results of the standard radiographic investigations and in some cases the usefulness of angiography, xeroradiography and telethermography. At presentation we also evaluated the possible diffusion of the disease with standard radiographic surveys (chest and skeletal, including limbs) and with foot lymphography in selected cases. In this way, 57 patients (69%) were considered to have localized disease. In this group, we also considered the value of the periodic radiographic follow-up, which enabled us to disclose the appearance of metastases (chest 64%, bone 54%, lymph nodes 11%) in 28 cases (49%). Finally, we made a comparison of the different radiologic and epidemiologic findings between children and adults.

  5. Perigastric extraskeletal Ewing's sarcoma: A case report

    Institute of Scientific and Technical Information of China (English)

    Radoje B Colovic; Nikica M Grubor; Marjan T Micev; Slavko V Matic; Henry Dushan Edward Atkinson; Stojan M Latincic

    2009-01-01

    Ewing's sarcoma (ES) is a neoplasm of undifferentiated small round cells, which occurs in the bones and deep soft tissues of children and adolescents. We present a rare case of a 44-year-old woman with gastric ES presenting with epigastric pain and weight loss. Ultrasound and computed tomography scans indicated a solid/cystic mass in the pancreatic tail. At laparotomy, the tumor was found attached to the posterior surface of the stomach, completely free from the pancreas, with no lymphadenopathy or local metastases. The polynodal, partly pseudocystic, dark-red soft tumor was excised. Histopathology revealed an anaplastic small-round-cell tumor with strong membranous CD99 immunoexpression. Additionally, there was patchy immunostaining for S-100 protein, vimentin, protein gene product (PGP) 9.5 and neuron-specific enolase, and weak focal CD117 cytoplasmic immunoreactivity. The patient had no adjuvant chemotherapy; her postoperative recovery was uneventful, and she remains symptom-free, and without any sign of recurrence at 20 mo. To the best of our knowledge, this is only the third ever case of gastric ES.

  6. Copy Number Alterations and Methylation in Ewing's Sarcoma

    Directory of Open Access Journals (Sweden)

    Mona S. Jahromi

    2011-01-01

    Full Text Available Ewing's sarcoma is the second most common bone malignancy affecting children and young adults. The prognosis is especially poor in metastatic or relapsed disease. The cell of origin remains elusive, but the EWS-FLI1 fusion oncoprotein is present in the majority of cases. The understanding of the molecular basis of Ewing's sarcoma continues to progress slowly. EWS-FLI1 affects gene expression, but other factors must also be at work such as mutations, gene copy number alterations, and promoter methylation. This paper explores in depth two molecular aspects of Ewing's sarcoma: copy number alterations (CNAs and methylation. While CNAs consistently have been reported in Ewing's sarcoma, their clinical significance has been variable, most likely due to small sample size and tumor heterogeneity. Methylation is thought to be important in oncogenesis and balanced karyotype cancers such as Ewing's, yet it has received only minimal attention in prior studies. Future CNA and methylation studies will help to understand the molecular basis of this disease.

  7. Stress-induced changes in immune response of dairy ewes

    Directory of Open Access Journals (Sweden)

    Agostino Sevi

    2010-01-01

    Full Text Available two groups of 16 Comisana ewes were selected from a group of 30, and divided, according to their cortisol secretion after isolation in a novel environment, into HC ewes, having a cortisol secretion >90 ng/mL, and LC ewes having a cortisol secretion <80 ng/mL. Blood samples were collected immediately before and immediately after isolation, and 60, 120, 300min and then 24h and 48h after isolation, to evaluate the percentage of lymphocyte T-helper (CD4+ and lymphocyte T-cytotoxic (CD8+ by flow cytometry analysis, and IL-1β and IL-6 concentrations by ELISA. The day before the isolation test, the ewes were milked in the afternoon at 1500h (-19h from isolation, and then milked for the three days starting from the day of the isolation test (at 0, 5, 24, 29, 48 and 53h from isolation to evaluate milk cortisol secretion, and IL-1β and IL-6 concentrations. Results suggest that the levels of cortisol secretions can influence the immune competence of dairy ewes and cytokines concentrations. Milk cytokine concentrations, and not milk cortisol concentrations, can be considered indicators of the magnitude of the hypothalamic-pituitary-adrenal axis activation.

  8. Effects of lipopolysaccharide (LPS) induced inflammatory response on early embryo survival in ewes

    Science.gov (United States)

    Early pregnant ewes were used to determine the effects of endogenous (through LPS activation) and exogenous TNF-alpha tumor necrosis factor-alpha (TNF-alpha) on embryonic loss. Thirty-eight Dorset x Texel ewes were synchronized for estrus and bred to fertile rams (d0). On d5/6, ewes were assigned t...

  9. Do ewes born with a male co-twin have greater longevity with lambing over time?

    Science.gov (United States)

    Based on a recent analysis of historical records, ewes born co-twin to a ram had greater lifetime reproductive performance than ewes born co-twin to a ewe. We are interested in determining what component(s) of lifetime reproductive performance may be associated with a ewe’s co-twin sex. As an initi...

  10. Safety and efficacy of low-dose, subacute exposure of mature ewes to sodium chlorate

    Science.gov (United States)

    The objective was to determine the safety and efficacy of low-dose, subacute exposure of mature ewes to NaClO3 in the drinking water. Twenty-five ewes (BW = 62.5 ± 7.3 kg) were placed indoors in individual pens with ad libitum access to water and feed. After 7 d of adaptation, ewes were assigned ran...

  11. CNOOC Cooperates with Santa Fe

    Institute of Scientific and Technical Information of China (English)

    Cao Sanyong; Wang Keyu

    1997-01-01

    @@ China National Offshore Oil Corporatian (CNOOC) signed the Petroleum Contract for 15/34 Block in the Pearl River Mouth Basin of South China Sea and the Petroleum Contract for 23/28 Block in the Beibu Gulf of South China Sea with Santa Fe Resources Inc. of the United States in Beijing on January 16, 1997.

  12. Adult Intramedullary Ewing Sarcoma of the Proximal Hip

    Directory of Open Access Journals (Sweden)

    Preetam Gongidi

    2014-01-01

    Full Text Available Ewing sarcoma of bone is classically a permeative lesion in the diaphysis of long bones in children. While they occur primarily in children and adolescents, they can be seen in young adults in their 20s, but these are typically seen in flat bones. The permeative nature of the lesion can elicit new bone formation creating a partially sclerotic appearance, cortical expansion presenting as a “Codman triangle,” or have an “onion-skin” type of aggressive periosteal reaction/periostitis. Ewing sarcoma is rarely seen without an associated soft-tissue mass and is even rarer to just have benign-appearing periostitis (e.g., thick, uniform, or wavy cortex. We present such a case of Ewing sarcoma in a young adult confined to just the medullary metadiaphysis without cortical erosion or soft-tissue mass. To the best of our knowledge, this is the first case to be reported in the radiology literature.

  13. Genetic Parameters of Some Economic Traits in Arabi Ewes

    Directory of Open Access Journals (Sweden)

    S F. Al-Dabbagh

    2013-12-01

    Full Text Available Data were analyzed of Arabi ewes flock (153 within productive years 1990-1999 to estimate the overall mean and genetic parameters which are heritability, repeatability, genetic and phenotypic correlations for fertility, litter size, ewes weight, lambs birth weights, milk and wool yield for this breed. The overall mean for fertility, litter size, ewes weight, lambs birth weights, daily milk yield and greasy fleece weight were 70.07%, 1.14, 50.24 kg, 4.52 kg, 0.59 kg and 1.67 kg respectively. Heritability estimates were low- moderate ranged (0.09-0.45. Repeatability estimates were low-high ranged (0.10-0.56. Genetic and phenotypic values of correlation between the traits were all highly significant (p≤ 0.01 except for the genetic and phenotypic correlation between birth weight and both daily milk yield, fertility, phenotypic correlation between greasy fleece weight and both fertility, litter size were non significant.

  14. Transarticular spread of Ewing sarcoma mimicking septic arthritis

    Energy Technology Data Exchange (ETDEWEB)

    Jordanov, Martin I.; Block, John J. [Vanderbilt University Medical Center, Department of Radiology and Radiological Sciences, Nashville, TN (United States); Gonzalez, Adriana L. [Vanderbilt University Medical Center, Department of Pathology, Nashville, TN (United States); Green, Neil E. [Vanderbilt Children' s Hospital, Department of Pediatric Orthopaedics, Nashville, TN (United States)

    2009-04-15

    Transarticular spread of tumor is rare; it has only been reported in the sacroiliac joint, intervertebral disk spaces, and facet joints. The anatomic and kinetic characteristics of the sacroiliac joint, as well as the changes the joint undergoes during a lifetime, make it particularly vulnerable to transarticular tumor invasion. Although extremely rare, Ewing sarcoma can extend through the sacroiliac joint and be virtually indistinguishable radiologically from septic arthritis. Furthermore, the clinical presentation of a child with Ewing sarcoma can be similar to that of a child with osteomyelitis. Laboratory values are quite nonspecific and are not always helpful in differentiating between the entities. Therefore, the possibility of sacroiliac joint transarticular Ewing sarcoma should be considered in a child presenting with hip pain, despite clinical, radiological and laboratory findings suggesting an infectious process. (orig.)

  15. Psychometric properties of the Korean version of the incivility in nursing education-revised (INE-R) survey.

    Science.gov (United States)

    De Gagne, Jennie C; Kang, Hee Sun; Hyun, Myung Sun

    2016-12-01

    In this study, we developed and tested the psychometric properties of a translated and culturally adapted Korean version of the Incivility in Nursing Education-Revised (INE-R) survey. Using a cross-sectional design, the INE-R was administered to a convenience sample of 284 students enrolled in three Korean nursing colleges. Descriptive statistics were calculated for 24 student and 24 faculty incivility behavior items. Underlying factor structure was examined using exploratory and confirmatory factor analyses, and model fit was assessed using chi-square goodness-of-fit and other fit indices. For student incivility items, a four-factor model provided the best fit for the data, while a two-factor model provided the best fit for faculty incivility items. Overall reliability of the INE-R for student and faculty incivility behavior was estimated as α = 0.94 and 0.96, respectively. The Korean version of the INE-R is a reliable measure for assessing perceptions of student and faculty incivility among Korean nursing students.

  16. Protéines végétales et risque allergique

    OpenAIRE

    Larré, Colette; Brossard, Chantal; Denery, Sandra; Lollier, Virginie; Lupi, Roberta

    2016-01-01

    L'augmentation de la part des protéines végétales dans l'alimentation humaine est une des réponses aux enjeux économiques, nutritionnels et écologiques des prochaines décennies. La connaissance actuelle des mécanismes et des molécules impliquées dans l’allergie alimentaire suggère toutefois un risque d’augmenter simultanément la prévalence de cette pathologie. Les familles protéiques fréquemment consommées et dans lesquelles se répartissent la majorité des allergènes alimentaires ont une cons...

  17. Clinical mastitis in ewes; bacteriology, epidemiology and clinical features

    Directory of Open Access Journals (Sweden)

    Kvitle Bjørg

    2007-09-01

    Full Text Available Abstract Background Clinical mastitis is an important disease in sheep. The objective of this work was to identify causal bacteria and study certain epidemiological and clinical features of clinical mastitis in ewes kept for meat and wool production. Methods The study included 509 ewes with clinical mastitis from 353 flocks located in 14 of the 19 counties in Norway. Clinical examination and collection of udder secretions were carried out by veterinarians. Pulsed-field gel electrophoresis (PFGE was performed on 92 Staphylococcus aureus isolates from 64 ewes. Results and conclusion S. aureus was recovered from 65.3% of 547 clinically affected mammary glands, coagulase-negative staphylococci from 2.9%, enterobacteria, mainly Escherichia coli, from 7.3%, Streptococcus spp. from 4.6%, Mannheimia haemolytica from 1.8% and various other bacteria from 4.9%, while no bacteria were cultured from 13.2% of the samples. Forty percent of the ewes with unilateral clinical S. aureus mastitis also had a subclinical S. aureus infection in the other mammary gland. Twenty-four of 28 (86% pairs of S. aureus isolates obtained from clinically and subclinically affected mammary glands of the same ewe were indistinguishable by PFGE. The number of identical pairs was significantly greater than expected, based on the distribution of different S. aureus types within the flocks. One-third of the cases occurred during the first week after lambing, while a second peak was observed in the third week of lactation. Gangrene was present in 8.8% of the clinically affected glands; S. aureus was recovered from 72.9%, Clostridium perfringens from 6.3% and E. coli from 6.3% of the secretions from such glands. This study shows that S. aureus predominates as a cause of clinical ovine mastitis in Norway, also in very severe cases. Results also indicate that S. aureus is frequently spread between udder halves of infected ewes.

  18. Combinatorial Drug Screening Identifies Ewing Sarcoma-specific Sensitivities

    DEFF Research Database (Denmark)

    Radic-Sarikas, Branka; Tsafou, Kalliopi P; Emdal, Kristina B.;

    2017-01-01

    including approved drugs. We were able to retrieve highly synergistic drug combinations specific for Ewing sarcoma and identified signaling processes important for Ewing sarcoma cell proliferation determined by EWS-FLI1 We generated a molecular target profile of PKC412, a multikinase inhibitor with strong...... and IGF1R inhibitors. The mechanism of the drug synergy between these inhibitors is different from the sum of the mechanisms of the single agents. The combination effectively inhibited pathway crosstalk and averted feedback loop repression, in EWS-FLI1-dependent manner. Mol Cancer Ther; 16(1); 88...

  19. Ewing sarcoma in adolescents and young adults: diagnosis and treatment

    Directory of Open Access Journals (Sweden)

    Davis LE

    2014-09-01

    Full Text Available Lara E Davis,1,2 Suman Malempati2 1Department of Medicine, 2Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA Abstract: Ewing sarcoma (ES is a rare tumor that most often occurs in adolescents and young adults. This review discusses the diagnosis, prognosis, and treatment of localized and metastatic ES, with an emphasis on the care of adolescent and young adult patients. The pathobiology is reviewed. Particular attention is given to recent and current clinical trials, and an introduction to future directions for therapy of ES is provided. Keywords: Ewing, sarcoma, primitive neuroectodermal tumor, PNET

  20. Effects of experimental Trypanosoma evansi infection on pregnancy in Yankasa ewes.

    Science.gov (United States)

    Adeyeye, A A; Ate, I U; Lawal, A I; Adamu, S

    2016-03-15

    Twenty pregnant Yankasa ewes were assigned to three groups to determine the effect of Trypanosoma evansi infection on pregnancy. Groups A and B comprising seven ewes each were infected with approximately 1.0 × 10(6) cells of T evansi per ewe through venepuncture at the second and third trimesters of pregnancy, respectively. Group C comprising six ewes served as uninfected control. There was slight pyrexia in the infected groups (groups A and B) but was absent in group C. The mean body weight, glucose concentration, and packed cell volume of ewes in group A were not significantly different from those in group C throughout the study. There was also no significant difference in mean glucose concentration between groups B and C. However, in group B, mean body weight was significantly (P gestation length between ewes in the infected groups (groups A and B) compared with those in group C. However, there were significant (P < 0.05) decreases in lamb birth weights of ewes in group B compared with ewes in groups A and C. Mice inoculation with blood from infected ewes postpartum was parasitemic 18 to 25 days pi, for ewes in group B, whereas none of the mice in groups A and C were parasitemic. Lambs born from the infected groups (groups A and B) were also aparasitemic for 40 days postpartum. It was therefore concluded that the T evansi isolate used caused mild trypanosomosis when infected at third trimester, whereas ewes infected at second trimester were resistant.

  1. Santa Paulina, reconquista a territorialidade

    OpenAIRE

    Nascimento, José do

    2006-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas. Programa de Pós-Graduação em História Esta dissertação trata de um estudo sobre a relação entre turismo e religiosidade a partir do estudo de caso do Santuário de Santa Paulina do Coração Agonizante de Jesus, em Nova Trento, no período de 1991 a 2005. Foi adotado o método de História Oral com a participação de diferentes atores, destacando-se os peregrinos ou passantes mais comumente de...

  2. Sarcoma de Ewing en paciente masculino Ewing's sarcoma in a male patient

    Directory of Open Access Journals (Sweden)

    Eddy Millán Escalona

    2010-09-01

    Full Text Available El sarcoma de Ewing es un tumor óseo maligno de células redondas pequeñas. Es el segundo tumor óseo maligno más frecuente en la infancia, y se puede presentar en cualquier momento durante la niñez y comienzos de la edad adulta. El tumor puede originarse en cualquier parte del cuerpo, generalmente en los huesos largos de las extremidades, la pelvis o el tórax, al igual que en el cráneo o en los huesos planos del tronco. Se trata de un paciente masculino, mestizo, de 38 años de edad, que acude a consulta externa en el hospital de Nickerie, Suriname, por presentar aumento de volumen en la región lateral derecha del abdomen. Refiere que ha presentado pérdida de peso, decaimiento marcado y anorexia. Estos síntomas se iniciaron 3 meses antes, y se han incrementado paulatina y progresivamente. Tiene también dificultad para deambular y dolor en la pierna derecha.The Ewing's sarcoma is a malignant bone tumor of round cells. The second malignant bone tumor more frequent in childhood and may to appear in any moment during this life stage and at onset of adulthood. Tumor may to originate in any place of body, generally in limbs long bones, pelvis or thorax as well as in skull or in trunk flat bones. This case is a black male patient aged 38 seen in external consultation in the hospital of Nickerie, Surinam presenting with a volume increase in the right lateral region of abdomen. He refers a weight loss, a marked weakness and anorexia. These symptoms appeared three months before increasing in a gradual and progressively way. He has difficulty to walk and pain in the right leg.

  3. 2009 Santa Fe Bone symposium.

    Science.gov (United States)

    Lewiecki, E Michael; Bilezikian, John P; Laster, Andrew J; Miller, Paul D; Recker, Robert R; Russell, R Graham G; Whyte, Michael P

    2010-01-01

    Osteoporosis is a common skeletal disease with serious clinical consequences because of fractures. Despite the availability of clinical tools to diagnose osteoporosis and assess fracture risk, and drugs proven to reduce fracture risk, it remains a disease that is underdiagnosed and undertreated. When treatment is started, it is commonly not taken correctly or long enough to be effective. Recent advances in understanding of the regulators and mediators of bone remodeling have led to new therapeutic targets and the development of drugs that may offer advantages over current agents in reducing the burden of osteoporotic fractures. Many genetic factors that play a role in the pathogenesis of osteoporosis and metabolic bone disease have now been identified. At the 2009 Santa Fe Bone Symposium, held in Santa Fe, New Mexico, USA, the links between advances in genetics, basic bone science, recent clinical trials, and new and emerging therapeutic agents were presented and explored. Socioeconomic challenges and opportunities in the care of osteoporosis were discussed. This is a collection of medical essays based on key presentations at the 2009 Santa Fe Bone Symposium.

  4. Microsatellites with Macro-Influence in Ewing Sarcoma

    Directory of Open Access Journals (Sweden)

    Stephen L. Lessnick

    2012-07-01

    Full Text Available Numerous molecular abnormalities contribute to the genetic derangements involved in tumorigenesis. Chromosomal translocations are a frequent source of these derangements, producing unique fusion proteins with novel oncogenic properties. EWS/ETS fusions in Ewing sarcoma are a prime example of this, resulting in potent chimeric oncoproteins with novel biological properties and a unique transcriptional signature essential for oncogenesis. Recent evidence demonstrates that EWS/FLI, the most common EWS/ETS fusion in Ewing sarcoma, upregulates gene expression using a GGAA microsatellite response element dispersed throughout the human genome. These GGAA microsatellites function as enhancer elements, are sites of epigenetic regulation and are necessary for EWS/FLI DNA binding and upregulation of principal oncogenic targets. An increasing number of GGAA motifs appear to substantially enhance EWS/FLI-mediated gene expression, which has compelling biological implications as these GGAA microsatellites are highly polymorphic within and between ethnically distinct populations. Historically regarded as junk DNA, this emerging evidence clearly demonstrates that microsatellite DNA plays an instrumental role in EWS/FLI-mediated transcriptional regulation and oncogenesis in Ewing sarcoma. This unprecedented role of GGAA microsatellite DNA in Ewing sarcoma provides a unique opportunity to expand our mechanistic understanding of how EWS/ETS fusions influence cancer susceptibility, prognosis and transcriptional regulation.

  5. Efficacy of ATR inhibitors as single agents in Ewing sarcoma

    DEFF Research Database (Denmark)

    Nieto-Soler, Maria; Morgado-Palacin, Isabel; Lafarga, Vanesa

    2016-01-01

    Ewing sarcomas (ES) are pediatric bone tumors that arise from a driver translocation, most frequently EWS/FLI1. Current ES treatment involves DNA damaging agents, yet the basis for the sensitivity to these therapies remains unknown. Oncogene-induced replication stress (RS) is a known source of en...

  6. Estimation of udder cistern size in dairy ewes by ultrasonography

    Directory of Open Access Journals (Sweden)

    Pavol Makovick

    2015-07-01

    Full Text Available We studied the size of mammary cistern in ewes of 9 genotypes (purebred Improved Valachian (IV, purebred Tsigai (T, purebred Lacaune (LC and their crosses with genetic proportion of specialized dairy breeds Lacaune and East Friesian (EF - (25 %, 50 % and 75 % were evaluated. Dana were evaluated using REML methodology and MIXED procedure (SAS/STAT. The effect of genotype showed the highest influence (P<0.001 on the length and area of the left and right udder cisterns measurements. In purebred IV ewes, the average areas of the left and right udder cisterns sizes were obtained by using the side method were (1519.39±77.212 mm2 and 1558.45±74.480 mm2. In purebred T ewes, the average areas of the left and right udder cisterns were (1438.70±70.43 mm2 and 1418.68±67.952 mm2. These were significantly smaller than in purebred LC (2694.44±71.95 mm2 and 2693.48±69.340 mm2. The udder cistern areas were significantly higher in crosses with 25 %, 50 % and 75 % genetic proportion of specialized dairy breeds LC and EF, than in purebred IV and T ewes. The analyses showed that crossbreeding of IV with LC and EF and T with LC and EF considerably increases ewe‘s cistern size.

  7. Primary extraskeletal Ewing's sarcoma/primitive neuroectodermal tumor of breast

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    Smita Srivastava

    2016-01-01

    Full Text Available Extraskeletal Ewing's sarcoma (EES is a rare soft tissue tumor that is morphologically indistinguishable from skeletal ES. We report a case of a 25-year-old female with recurrent EES/primitive neuroectodermal tumor of right breast with imaging findings on mammogram, ultrasound, magnetic resonance imaging breast, and positron emission tomography–computed tomography.

  8. In vivo modelling of Ewing sarcoma in zebrafish

    NARCIS (Netherlands)

    Ent, Wietske van der

    2015-01-01

    Ewing sarcoma (EWS) is a disease with a high need for novel therapeutic strategies. To aid in investigating such compounds in an in vivo setting, we have developed several zebrafish model systems for EWS, which are presented in this thesis. The first is a manual xenograft model in 2-day-old

  9. South Fork of the Santa Clara River, Santa Clarita Valley, California. Supplement.

    Science.gov (United States)

    1985-01-01

    Santa Eriodictyon trichocalyx Eucrypta Eucrypta chrysanthemifolia LAMIACEAE Purple Sage Salvia leucophylla PAEONIACEAE Peony Paeonia californica...Bush Lupine Lupinus ex-cubitus HYDROPHYLLACEAE Yerba Santa Eriodictyon trichocaLx Eucrypta Eucrypta chrysanthemifolia LAMIACEAE Purple Sage Salvia

  10. Propriétés fonctionnelles - Modifications chimiques des protéines alimentaires et étude des relations structure/fonction

    Directory of Open Access Journals (Sweden)

    Vidal Véronique

    2003-01-01

    Full Text Available Les modifications chimiques des protéines alimentaires sont réalisées dans le but d’ améliorer leurs propriétés fonctionnelles. Elles sont également pratiquées pour des études fondamentales des relations structure/fonction des protéines. Les principales modifications chimiques des protéines alimentaires sont présentées ainsi que leurs incidences sur les propriétés fonctionnelles telles les propriétés émulsifiantes, moussantes, visqueuses, d’hydratation et de gélification.

  11. Povezanost veličine legla s proizvodnjom mlijeka, morfologijom i zdravljem vimena istočnofrizijskih ovaca

    OpenAIRE

    PRPIĆ, Zvonimir; Vnučec, Ivan; Benić, Miroslav; Mioč, Boro

    2016-01-01

    The aim of this study was to determine relationship between litter size and milk yield, udder morphology, and udder health of East Friesian ewes. For that purpose a total of 80 East Friesian ewes, from 2nd to 4th lactation, with symmetrical udders, without visible (clinical) signs of mastitis were involved in this study. Until weaning at average age of 60±5 days lambs suckled their mothers exclusively. During milking period regular milking controls (on a monthly basis) were carried out (AT me...

  12. Ewing sarcoma of the oral cavity. A review

    Science.gov (United States)

    Bagán, José; Poveda-Roda, Rafael

    2017-01-01

    Objectives A review is made of the clinical, diagnostic, therapeutic and survival characteristics of Ewing sarcoma (ES) of the oral cavity. Material and Methods A systematic literature search was carried out, with restrictions referred to time (1960-2014), language (English and Spanish) and type of study (case reports, letters, datasets, reviews). The following MeSH terms and boolean operators were used: Ewing AND Sarcoma AND [tongue, jaw, maxilla, cheek, condyle OR temporomandibular, floor AND mouth, gum OR gingiva, palate OR palatal, lip, uvula, head AND neck]. Results Seventy-one cases of ES of the oral cavity were documented from 53 articles. The main differences versus ES of other locations were a younger age at manifestation, a shorter time from symptoms onset to diagnosis, and swelling as the most frequent clinical manifestation versus swelling and pain in the rest of disease locations. The way in which ES manifests in the oral cavity is varied and comprises dental displacement (19.7%), dental mobility (7%), root reabsorption (5.6%), destruction of the dental follicle (4.2%), premature exfoliation (4.2%) and paresthesia of the chin (2.8%). Metastatic neck adenopathies appear in 11.3% of the cases. Significant differences in survival are observed between patients with a complete diagnosis of ES (hematoxylin-eosin staining, PAS positivity, CD99 positivity) and those with an incomplete diagnosis. Conclusions Ewing sarcoma of the oral cavity presents a series of specific features that distinguish it from ES of other locations. Key words:Primitive neuroectodermal tumor, PNET, Ewing sarcoma, Ewing tumor, sarcoma, oral cavity. PMID:28210452

  13. Progesterone administration reduces the behavioural and physiological responses of ewes to abrupt weaning of lambs.

    Science.gov (United States)

    Freitas-de-Melo, A; Banchero, G; Hötzel, M J; Damián, J P; Ungerfeld, R

    2013-08-01

    Abrupt weaning, a usual management in sheep productive systems, may provoke behavioural and physiological responses indicative of stress in ewes and lambs. Progesterone (P4) has anxiolytic and sedative effects through the union of its metabolites that contain 3α-hydroxyl group to the γ-aminobutyricacidA receptor. Our first aim was to determine whether P4 administration reduces the behavioural and physiological responses of ewes to abrupt weaning of lambs. A complementary aim was to determine whether P4 treatment affects the milk yield and composition of ewes, and the BW of their lambs. In experiment 1, seven ewes received P4 treatment for 32 days (group E1-P4), and eight ewes remained as an untreated control group (group E1-C). BW of the lambs was recorded during P4 treatment. Lambs were weaned at 59 days (Day 0 = weaning). The main behaviours of the ewes before and after weaning were recorded using 10 min scan sampling. The ewes' serum total protein, albumin and globulin concentrations were measured before and after weaning of the lambs. In experiment 2, milk yield and composition were determined in two different groups of six ewes treated with P4 (group E2-P4) for 16 days and in five untreated controls (group E2-C). The BW of lambs increased with time (P = 0.001) in both groups and did not differ. The percentage of observations in which the ewes were seen pacing on Day 0 was greater in the E1-C group than in the E1-P4 group (P = 0.0007). Similarly, the percentage of observations in which the ewes were recorded vocalizing on Day 0 was greater in the E1-C group than in the E1-P4 group (P = 0.04). The percentage of observations in which E1-C ewes were recorded lying did not change from Days 0 to 1; however, it increased in E1-P4 ewes. Total serum protein concentration did not change in E1-P4 ewes from Days 0 to 3, although a decrease was seen in E1-C ewes (P = 0.04). Serum globulin concentration was greater in E1-P4 ewes on Day 3 than in E1-C ewes (P = 0.0008). In

  14. Extraosseous Ewing's sarcoma: review of a case. Sarcoma de Ewing extraoseo: revision a proposito de un caso

    Energy Technology Data Exchange (ETDEWEB)

    Quevedo Moreno, P.; Hernandez Moreno, L.; Perez Diaz, M.; Lafuente Martinez, J.L.; Arozamena Laso, M.

    1994-01-01

    Extraosseous Ewing's sarcoma (EES) is an uncommon lesion included in the group of soft tissue tumors. We present a case in a 19-year-old woman in which the diagnosis was not initially suspected because of the absence of clinical and radiological evidence. (Author)

  15. Efficacy of repeated doses of levamisole, morantel, fenbendazole, and ivermectin against gastrointestinal nematodes in ewes.

    Science.gov (United States)

    Hembry, F G; Miller, J E; Sims, D; Rodriguez, S; Stagg, L C

    1986-08-01

    Levamisole, morantel, fenbendazole, or ivermectin was administered at 2-week intervals from May 1 through Sept 14, 1985, to breeding ewes (20 ewes/drug) infected with various gastrointestinal nematodes. All ewes had fewer gastrointestinal nematode eggs per gram of feces (epg) after 2 treatments, compared with pretreatment epg counts. Ewes administered ivermectin continued to have a low mean epg (0 to 3) throughout the study. The mean epg counts of ewes treated with levamisole increased from 3 to 483 during the study. This increase was similar to that of ewes treated with morantel (7 to 485 epg). The mean epg count of fenbendazole-treated ewes increased from 4 to 192 during the study. By the end of the study, the mean epg counts when expressed as a percentage of the pretreatment epg counts were 4% (ivermectin), 249% (fenbendazole), 627% (levamisole), and 630% (morantel). With the exception of the ivermectin-treated ewes, the epg count increased almost linearly in the ewes after the 2nd anthelmintic treatment. These data indicate that the gastrointestinal nematodes (including Haemonchus contortus) may have developed more resistance to levamisole and morantel than to fenbendazole. On the basis of the epg counts, resistance to ivermectin did not develop during the 4.5-month treatment period. The percentage of ewes shedding eggs after 2, 4, and 6 anthelmintic treatments was lowest for ewes treated with ivermectin (20%) and was similar (40%) for ewes treated with 1 of the other 3 anthelmintics. At the conclusion of the study, most of the ewes (90%) were shedding at least a small number of eggs, regardless of the anthelmintic treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

  16. 18F-FLT Positron Emission Tomography and Diffusion-Weighted Magnetic Resonance Imaging in Planning Surgery and Radiation Therapy and Measuring Response in Patients With Newly Diagnosed Ewing Sarcoma

    Science.gov (United States)

    2016-03-15

    Adult Supratentorial Primitive Neuroectodermal Tumor (PNET); Ewing Sarcoma of Bone; Extraosseous Ewing Sarcoma; Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor

  17. BCOR-CCNB3 (Ewing-like) sarcoma: a clinicopathologic analysis of 10 cases, in comparison with conventional Ewing sarcoma.

    Science.gov (United States)

    Puls, Florian; Niblett, Angela; Marland, Gillian; Gaston, Czar Louie L; Douis, Hassan; Mangham, D Chas; Sumathi, Vaiyapuri P; Kindblom, Lars-Gunnar

    2014-10-01

    BCOR-CCNB3 fusion transcripts resulting from an X-chromosomal paracentric inversion were recently identified in a series of unclassifiable soft tissue and bone sarcomas with Ewing sarcoma-like morphology. The morphologic and clinical features of these sarcomas are, as yet, not well characterized. Here we describe the clinicopathologic features of 10 cases of BCOR-CCNB3 sarcoma and compare their clinical course with typical Ewing sarcoma. Nine of 10 patients were male, and all were 11 to 18 years of age. Seven tumors were located in the bone and 3 in the deep soft tissues. The histomorphologic spectrum was quite wide, with 7 tumors predominately showing small primitive cell morphology with angulated nuclei simulating so-called atypical Ewing sarcoma and 3 predominately showing spindle cell morphology. Recurrent and metastatic lesions showed increased cellularity and marked pleomorphism. Immunohistochemistry showed expression of CCNB3 (100%), bcl2 (90%), CD99 (60%), and CD117 (60%). Reverse transcription polymerase chain reaction for BCOR-CCNB3 fusion transcripts was positive in all 9 cases, which yielded sufficient extracted RNA. Five- and 10-year survival rates were 75% and 56%, respectively. BCOR-CCNB3 sarcomas located in axial skeleton and soft tissues showed a significantly shorter survival. The Ewing sarcoma overall survival was not statistically different, although there was a trend for longer survival of patients with BCOR-CCNB3 sarcomas in the extremities. In conclusion, this study provides a detailed description of the histologic spectrum, immunohistochemical features, and clinical characteristic of BCOR-CCNB3 sarcoma justifying distinction from Ewing sarcoma with its typical EWS/FUS-ETS translocations. Ideally immunohistochemistry is used in combination with reverse transcription polymerase chain reaction for definitive diagnosis.

  18. EXPRESSION IN VIVO DU GÈNE GFP SOUS LA FORME D’UNE PROTÉINE DE FUSION

    Directory of Open Access Journals (Sweden)

    Lucian Negura

    2006-08-01

    Full Text Available La protéine GFP (Green Fluorescent Protein se caractérise par sa capacité à émettre sous l’action des rayons UV une lumière verte de basse énergie, ce qui la rend particulièrement utile en biotechnologies. Nous avons procédé à la production de la GFP in vivo par Eschericha coli sous forme d’une protéine chimère de fusion avec le peptide de la –Galactosidase. Pour ce, nous avons cloné un fragment d’ADN comportant la phase codante de la GFP à partir d’un vecteur dans lequel il ne peut être exprimé vers un autre vecteur permettant lui cette expression.

  19. Effects of exogenous progesterone on gestation length, foetal survival and colostrum yield in ewes.

    Science.gov (United States)

    Crosby, T F; O'Donnell, A; O'Doherty, J V; Quinn, P J; Evans, A C O

    2005-09-15

    Twin bearing mature ewes (n=40) were treated with exogenous progesterone (100mg daily in oil) or vehicle (oil control) from Day 143 of gestation until lambing to investigate the effects on gestation length, foetal survival and colostrum yield and composition. Compared to control ewes, progesterone treated ewes had increased (Pgestation length (150.4+/-0.6 days versus 147.8+/-0.6 days, Pgestation length and reduced lamb survival but did not lower colostrum yield.

  20. Ovarian Follicular Atresia of Ewes during Spring Puerperium

    Directory of Open Access Journals (Sweden)

    Radoslava Vlčková

    2012-01-01

    Full Text Available The distribution of healthy and atretic follicles on the ovarian surface of improved Valachian ewes 17, 24, and 32 days postpartum is reported in this study. The number of healthy follicles was higher on day 24 postpartum and their mean diameter tended to increase to day 32 (P<0.05 with the greatest diameter of 5 mm. 78–81% of atretic follicles ≥3 mm in diameter was observed where apoptosis began in the follicular cells situated at the follicular cavity. The early atretic follicles are characterized by the presence of mitotic pictures. In one ewe 24 days postpartum, small regressive follicular cysts were observed. Contracting atresia is characterized by thickening of the theca interna even to 190 μm. Progesterone and oestradiol-17β concentrations were maintained at relatively low levels, but with no significant difference between the days postpartum.

  1. Primitive neuroectodermal tumor/Ewing sarcoma of the retina.

    Science.gov (United States)

    Grossniklaus, Hans E; Shehata, Bahig; Sorensen, Poul; Bergstrom, Chris; Hubbard, G Baker

    2012-07-01

    An 11-year-old boy underwent enucleation of his left eye for an intraocular tumor. Examination showed a small, round blue cell tumor arising in the peripheral retina near the ciliary body. Immunohistochemical stain results were positive for neuron-specific enolase, synaptophysin, cluster of differentiation 99 (CD99), Friend leukemia integration 1, and CD56. Ultrastructural findings included occasional intracytoplasmic dense core granules. Polymerase chain reaction of the tumor showed a Ewing sarcoma/Friend leukemia integration gene fusion product. The tumor was classified as a primitive neuroectodermal tumor/Ewing sarcoma of the retina and should be distinguished from retinoblastoma. To our knowledge, this is the first case of primary primitive neuroectodermal tumor of the retina.

  2. Ewing sarcoma mimicking a peripheral nerve sheath tumor.

    Science.gov (United States)

    Mitchell, B D; Fox, B D; Viswanathan, A; Mitchell, A H; Powell, S Z; Cech, D A

    2010-10-01

    We describe the first patient with an extradural, extramedullary Ewing's sarcoma tumor mimicking a nerve sheath tumor with no overt evidence of metastasis. A 28-year-old woman with no past medical history presented with a progressive 3-year history of low back pain and right-sided lower extremity radiculopathy after having failed conservative therapies. MRI of the lumbar spine revealed a right-sided enhancing, dumbbell-shaped lesion at the right neural foramen appearing to originate from the L4 nerve root, suspicious for a peripheral nerve sheath tumor or schwannoma. The patient and findings are discussed in the context of the literature, including an update on the relatively recent diagnostic redesignation of the Ewing's sarcoma family tumors.

  3. Phenotypic characterization of the population of creole wool ewes in the highlands of Puebla State, Mexico.

    Science.gov (United States)

    Vargas-López, Samuel; Guerrero-Rodríguez, Juan de Dios; Rojas-Álvarez, Joel; Bustamante-González, Angel

    2012-12-01

    This study characterized the population of wool ewes in the highlands of the State of Puebla, Mexico, considering traits such as fleece color, weight, and body measurements. In this region, dominated by a temperate climate, sheep are a traditional animal species for farming systems. To carry out the work, 2,082 ewes were randomly selected from 14 communities and 124 flocks belonging to the six municipalities that have the largest inventory of sheep in the state. For each ewe, live weight, breed, fleece color pattern, and 18 other body measurements were recorded. Descriptive statistics were estimated for weight and body traits and the morphotype was classified by multivariate analysis. Factor analysis identified the bulk, size, and breed standard as the attributes that best describe the population of ewes. These elements varied in importance among the groups (p < 0.05). Cluster analysis helped to classify the population into small black-faced ewes (28.5 %), small white ewes (11.9 %), black-faced medium-sized ewes (24.1 %), large ewes (12.3 %), and white medium-sized ewes (23.2 %). The groups identified were similar to creole sheep present in rural communities in other environments, but have lower morphostructural values than specialized breeds.

  4. Dystocia due to schistosomus reflexus (cojoined twins in a Yankassa ewe

    Directory of Open Access Journals (Sweden)

    Ambali Hauwa Motunrayo

    2015-04-01

    Full Text Available A two years' old, white and brown Yankassa ewe, weighing 20 kg was presented with dystocia of about 48 h duration at Mabs Veterinary Centre Ltd, Lagos. On thorough physical and vaginal examination, there were evidences of feotal parts and foul smelling discharges per vagina. A systematic and calculated traction and retropulsion revealed schistosomus reflexus cojoined twins. There was a complete recovery of the ewe 3 days post operative management. Finally, this case reported a true schistosomus reflexus cojoined twins in Yankassa ewe which was successfully relieved through traction and retropulsion despite the supposedly small birth canal which precluded the procedure in ewes except for caesarian section or fetotomy

  5. Recent advances in targeted therapy for Ewing sarcoma [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Kathleen I. Pishas

    2016-08-01

    Full Text Available Ewing sarcoma is an aggressive, poorly differentiated neoplasm of solid bone that disproportionally afflicts the young. Despite intensive multi-modal therapy and valiant efforts, 70% of patients with relapsed and metastatic Ewing sarcoma will succumb to their disease. The persistent failure to improve overall survival for this subset of patients highlights the urgent need for rapid translation of novel therapeutic strategies. As Ewing sarcoma is associated with a paucity of mutations in readily targetable signal transduction pathways, targeting the key genetic aberration and master regulator of Ewing sarcoma, the EWS/ETS fusion, remains an important goal.

  6. Targeting the p53 Pathway in Ewing Sarcoma

    OpenAIRE

    Neilsen, Paul M.; Pishas, Kathleen I.; Callen, David F; Thomas, David M.

    2011-01-01

    The p53 tumour suppressor plays a pivotal role in the prevention of oncogenic transformation. Cancers frequently evade the potent antitumour surveillance mechanisms of p53 through mutation of the TP53 gene, with approximately 50% of all human malignancies expressing dysfunctional, mutated p53 proteins. Interestingly, genetic lesions in the TP53 gene are only observed in 10% of Ewing Sarcomas, with the majority of these sarcomas expressing a functional wild-type p53. In addition, the p53 downs...

  7. Prions in milk from ewes incubating natural scrapie.

    Science.gov (United States)

    Lacroux, Caroline; Simon, Stéphanie; Benestad, Sylvie L; Maillet, Séverine; Mathey, Jacinthe; Lugan, Séverine; Corbière, Fabien; Cassard, Hervé; Costes, Pierrette; Bergonier, Dominique; Weisbecker, Jean-Louis; Moldal, Torffin; Simmons, Hugh; Lantier, Frederic; Feraudet-Tarisse, Cécile; Morel, Nathalie; Schelcher, François; Grassi, Jacques; Andréoletti, Olivier

    2008-12-01

    Since prion infectivity had never been reported in milk, dairy products originating from transmissible spongiform encephalopathy (TSE)-affected ruminant flocks currently enter unrestricted into the animal and human food chain. However, a recently published study brought the first evidence of the presence of prions in mammary secretions from scrapie-affected ewes. Here we report the detection of consistent levels of infectivity in colostrum and milk from sheep incubating natural scrapie, several months prior to clinical onset. Additionally, abnormal PrP was detected, by immunohistochemistry and PET blot, in lacteal ducts and mammary acini. This PrP(Sc) accumulation was detected only in ewes harbouring mammary ectopic lymphoid follicles that developed consequent to Maedi lentivirus infection. However, bioassay revealed that prion infectivity was present in milk and colostrum, not only from ewes with such lympho-proliferative chronic mastitis, but also from those displaying lesion-free mammary glands. In milk and colostrum, infectivity could be recovered in the cellular, cream, and casein-whey fractions. In our samples, using a Tg 338 mouse model, the highest per ml infectious titre measured was found to be equivalent to that contained in 6 microg of a posterior brain stem from a terminally scrapie-affected ewe. These findings indicate that both colostrum and milk from small ruminants incubating TSE could contribute to the animal TSE transmission process, either directly or through the presence of milk-derived material in animal feedstuffs. It also raises some concern with regard to the risk to humans of TSE exposure associated with milk products from ovine and other TSE-susceptible dairy species.

  8. Prions in milk from ewes incubating natural scrapie.

    Directory of Open Access Journals (Sweden)

    Caroline Lacroux

    2008-12-01

    Full Text Available Since prion infectivity had never been reported in milk, dairy products originating from transmissible spongiform encephalopathy (TSE-affected ruminant flocks currently enter unrestricted into the animal and human food chain. However, a recently published study brought the first evidence of the presence of prions in mammary secretions from scrapie-affected ewes. Here we report the detection of consistent levels of infectivity in colostrum and milk from sheep incubating natural scrapie, several months prior to clinical onset. Additionally, abnormal PrP was detected, by immunohistochemistry and PET blot, in lacteal ducts and mammary acini. This PrP(Sc accumulation was detected only in ewes harbouring mammary ectopic lymphoid follicles that developed consequent to Maedi lentivirus infection. However, bioassay revealed that prion infectivity was present in milk and colostrum, not only from ewes with such lympho-proliferative chronic mastitis, but also from those displaying lesion-free mammary glands. In milk and colostrum, infectivity could be recovered in the cellular, cream, and casein-whey fractions. In our samples, using a Tg 338 mouse model, the highest per ml infectious titre measured was found to be equivalent to that contained in 6 microg of a posterior brain stem from a terminally scrapie-affected ewe. These findings indicate that both colostrum and milk from small ruminants incubating TSE could contribute to the animal TSE transmission process, either directly or through the presence of milk-derived material in animal feedstuffs. It also raises some concern with regard to the risk to humans of TSE exposure associated with milk products from ovine and other TSE-susceptible dairy species.

  9. SINCRONIZAÇÃO DE ESTRO COM PROSTAGLANDINA F2α versus PROGESTÁGENO ASSOCIADO À GONADOTROFINA CORIÔNICA EQUINA (eCG EM OVELHAS SANTA INÊS NO DISTRITO FEDERAL, BRASIL

    Directory of Open Access Journals (Sweden)

    Bianca Damiani Marques Silva

    2010-06-01

    Full Text Available The aim of this study was to compare two protocols ofestrus synchronization in Santa Inês ewes. Thirty-eight ewes wererandomly divided into two groups of estrus synchronization: protocolPGF2α (two doses of 0.530 mg of PGF2α, nine days apartand protocol MAP+eCG (intravaginal sponge impregnated withmedroxyprogesterone acetate, for 12 days, and then an injectionof 250 IU of eCG. The experiment was in a cross-over design,two estrous cycles apart. On the final day of protocol, a transrectalultrasound examination was carried out to measure the size of thelargest and second largest ovarian follicles and on day 7 of estrouscycle blood was collected to measure serum P4 concentration.Laparoscopy was carried out on day 11 after the end of protocols to count corpora lutea. Synchronization rate, size of largest andsecond largest ovarian follicles, interval between the end of theprotocol to estrus and ovulation rate did not differ between protocols.Ewes synchronized with MAP+eCG had greater serumP4 concentrations than ewes synchronized with PGF2α (3.9 and2.8 ng/mL, respectively, P<0.05. Based on the results, it may beconcluded that, although the protocol MAP+eCG was superior ininducing higher serum concentration of P4, the protocol PGF2αwas equivalent regarding estrus synchronization.

  10. Targeting the p53 Pathway in Ewing Sarcoma

    Directory of Open Access Journals (Sweden)

    Paul M. Neilsen

    2011-01-01

    Full Text Available The p53 tumour suppressor plays a pivotal role in the prevention of oncogenic transformation. Cancers frequently evade the potent antitumour surveillance mechanisms of p53 through mutation of the TP53 gene, with approximately 50% of all human malignancies expressing dysfunctional, mutated p53 proteins. Interestingly, genetic lesions in the TP53 gene are only observed in 10% of Ewing Sarcomas, with the majority of these sarcomas expressing a functional wild-type p53. In addition, the p53 downstream signaling pathways and DNA-damage cell cycle checkpoints remain functionally intact in these sarcomas. This paper summarizes recent insights into the functional capabilities and regulation of p53 in Ewing Sarcoma, with a particular focus on the cross-talk between p53 and the EWS-FLI1 gene rearrangement frequently associated with this disease. The development of several activators of p53 is discussed, with recent evidence demonstrating the potential of small molecule p53 activators as a promising systemic therapeutic approach for the treatment of Ewing Sarcomas with wild-type p53.

  11. Resumption of cyclic ovarian activity in postpartum ewes: a review

    Directory of Open Access Journals (Sweden)

    Ivan Júnior Ascari

    2016-04-01

    Full Text Available The reproduction rate is considered a crucial factor that affects the ability of producers to meet the growing demand for ovines meat, and optimizing this factor will maximize the production rate and increase the efficiency of livestock. A reduction in the length of the postpartum anestrus period results in a shorter interval between lambing and conception and enables more lambs to be produced throughout the life of a ewe. This review discusses the current knowledge of several factors associated with the resumption of cyclic ovarian function in postpartum ewes and how the suckling management of ewes may affect this process. Factors that influence the resumption of cyclic ovarian activity include uterine involution, follicular development, occurrence of silent ovulation and short estrous cycles, breed, reproductive seasonality, nutrition and lactation. Controlled suckling and early weaning are management practices that may be used to obtain three lambings in a 24-month period. In the majority of the studies the interval between lambing and first estrus was reduced when a controlled suckling management strategy was used, therefore the controlled suckling appears to be the best alternative because it has produced good results and is easy to implement. Currently, however, this practice is still not widely used.

  12. Santa Barbara Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Hacker, Angela; Hansen, Sherman; Watkins, Ashley

    2013-11-30

    This report serves as the Final Report for Santa Barbara County’s Energy Efficiency and Conservation Block Grant (EECBG) BetterBuildings Neighborhood Program (BBNP) award from the U.S. Department of Energy (DOE). This report explains how DOE BBNP funding was invested to develop robust program infrastructure designed to help property owners complete energy improvements, thereby generating substantial outcomes for the local environment and economy. It provides an overview of program development and design within the grant period, program accomplishments and challenges to date, and a plan for the future sustainability of emPower, the County’s innovative clean energy and building efficiency program. During the grant period, Santa Barbara County’s emPower program primarily targeted 32,000 owner occupied, single family, detached residential homes over 25 years old within the County. In order to help these homeowners and their contractors overcome market barriers to completing residential energy improvements, the program developed and promoted six voluntary, market-based service areas: 1) low cost residential financing (loan loss reserve with two local credit unions), 2) residential rebates, 3) local customer service, 4) expert energy advising, 5) workforce development and training, and 6) marketing, education and outreach. The main goals of the program were to lower building energy use, create jobs and develop a lasting regional building performance market. These services have generated important early outcomes and lessons after the program’s first two years in service. The DOE BBNP funding was extended through October 2014 to enable Santa Barbara County to generate continued outcomes. In fact, funding related to residential financing remains wholly available for the foreseeable future to continue offering Home Upgrade Loans to approximately 1,300 homeowners. The County’s investment of DOE BBNP funding was used to build a lasting, effective, and innovative

  13. The SantaBot experiment

    DEFF Research Database (Denmark)

    Hansen, Søren Tranberg; Svenstrup, Mikael; Andersen, Hans Jørgen

    2009-01-01

    interactive mobile agents into public urban transit area. To investigate the hypothesis, an experiment was carried out using a robot capable of navigating autonomously based on the input of an onboard laser scanner. The robot would detect and follow random people, who afterwards were asked to fill out......The video shows how an autonomous mobile robot dressed as Santa Claus is interacting with people in a shopping mall. The underlying hypothesis is that it is possible to create interesting new living spaces and induce value in terms of experiences, information or economics, by putting socially...... a questionnaire for quantitative analysis of the experiment. The presented video is the corresponding video documentation of the experiment used in the evaluation. The results showed that people were generally positive towards having mobile robots in this type of environment where shopping is combined...

  14. The relationship between trace mineral concentrations of amniotic fluid with placenta traits in the pregnancy toxemia Ghezel ewes

    Directory of Open Access Journals (Sweden)

    Ali Olfati

    2016-07-01

    Conclusions: Overall, determinations of these trace minerals in the AF ewes could have been used to obtain information on nutritional and reproductive status for the diagnosis of pregnancy toxemia in Ghezel ewes.

  15. Effect of protein degradability on milk production of dairy ewes.

    Science.gov (United States)

    Mikolayunas-Sandrock, C; Armentano, L E; Thomas, D L; Berger, Y M

    2009-09-01

    The objective of this experiment was to determine the effect of protein degradability of dairy sheep diets on milk yield and protein utilization across 2 levels of milk production. Three diets were formulated to provide similar energy concentrations and varying concentrations of rumen-degradable protein (RDP) and rumen-undegradable protein (RUP): 12% RDP and 4% RUP (12-4) included basal levels of RDP and RUP, 12% RDP and 6% RUP (12-6) included additional RUP, and 14% RDP and 4% RUP (14-4) included additional RDP. Diets were composed of alfalfa-timothy cubes, whole and ground corn, whole oats, dehulled soybean meal, and expeller soybean meal (SoyPlus, West Central, Ralston, IA). Estimates of RDP and RUP were based on the Small Ruminant Nutrition System model (2008) and feed and orts were analyzed for Cornell N fractions. Eighteen multiparous dairy ewes in midlactation were divided by milk yield (low and high) into 2 blocks of 9 ewes each and were randomly assigned within block (low and high) to 3 pens of 3 ewes each. Dietary treatments were arranged in a 3 x 3 Latin square within each block and applied to pens for 14-d periods. We hypothesized that pens consuming high-RUP diets (12-6) would produce more milk and milk protein than the basal diet (12-4) and pens consuming high-RDP diets (14-4) would not produce more milk than the basal diet (12-4). Ewes in the high-milk-yield square consumed more dry matter and produced more milk, milk fat, and milk protein than ewes in the low-milk-yield square. There was no effect of dietary treatment on dry matter intake. Across both levels of milk production, the 12-6 diet increased milk yield by 14%, increased milk fat yield by 14%, and increased milk protein yield by 13% compared with the 14-4 and 12-4 diets. Gross N efficiency (milk protein N/intake protein N) was 11 and 15% greater in the 12-6 and 12-4 diets, respectively, compared with the 14-4 diet. Milk urea N concentration was greater in the 12-6 diet and tended to be

  16. Dietary -carbamylglutamate and rumen-protected -arginine supplementation ameliorate fetal growth restriction in undernourished ewes.

    Science.gov (United States)

    Zhang, H; Sun, L W; Wang, Z Y; Deng, M T; Zhang, G M; Guo, R H; Ma, T W; Wang, F

    2016-05-01

    This study was conducted with an ovine intrauterine growth restriction (IUGR) model to test the hypothesis that dietary -carbamylglutamate (NCG) and rumen-protected -Arg (RP-Arg) supplementation are effective in ameliorating fetal growth restriction in undernourished ewes. Beginning on d 35 of gestation, ewes were fed a diet providing 100% of NRC-recommended nutrient requirements, 50% of NRC recommendations (50% NRC), 50% of NRC recommendations supplemented with 20 g/d RP-Arg (providing 10 g/d of Arg), and 50% of NRC recommendations supplemented with 5 g/d NCG product (providing 2.5 g/d of NCG). On d 110, maternal, fetal, and placental tissues and fluids were collected and weighed. Ewe weights were lower ( < 0.05) in nutrient-restricted ewes compared with adequately fed ewes. Maternal RP-Arg or NCG supplementation did not alter ( = 0.26) maternal BW in nutrient-restricted ewes. Weights of most fetal organs were increased ( < 0.05) in RP-Arg-treated and NCG-treated underfed ewes compared with 50% NRC-fed ewes. Supplementation of RP-Arg or NCG reduced ( < 0.05) concentrations of β-hydroxybutyrate, triglycerides, and ammonia in serum of underfed ewes but had no effect on concentrations of lactate and GH. Maternal RP-Arg or NCG supplementation markedly improved ( < 0.05) concentrations of AA (particularly arginine-family AA and branched-chain AA) and polyamines in maternal and fetal plasma and in fetal allantoic and amniotic fluids within nutrient-restricted ewes. These novel results indicate that dietary NCG and RP-Arg supplementation to underfed ewes ameliorated fetal growth restriction, at least in part, by increasing the availability of AA in the conceptus and provide support for its clinical use to ameliorate IUGR in humans and sheep industry production.

  17. Tendance de marché en France sur la présence des protéines végétales dans les produits alimentaires

    Directory of Open Access Journals (Sweden)

    Estève-Saillard Morgane

    2016-07-01

    Full Text Available Le contexte actuel est favorable à l’utilisation croissante des protéines végétales dans les produits alimentaires : préoccupations sanitaires et environnementales, développement du flexitarisme et dans une moindre mesure du végétarisme, inscriptions des protéines végétales dans les secteurs de recherche stratégiques pour la France...Le bilan de référencement du GEPV, Groupe d’Étude et de Promotion des Protéines Végétales, fait le point tous les deux ans sur la présence des protéines végétales dans les produits alimentaires commercialisés en France. Les résultats du dernier bilan montrent la nette progression de l’utilisation de protéines végétales dans tous les rayons alimentaires, en progression constante depuis plusieurs années. Le blé reste la source largement majoritaire, suivi par le soja. Des spécificités se dégagent dans l’utilisation des ingrédients protéiques végétaux; par exemple les protéines de pois et de soja sont principalement utilisées pour les produits carnés alors que le gluten et la féverole sont surtout utilisés pour les produits de panification. De nouvelles utilisations des sources protéiques voient également le jour et feront l’objet d’un suivi du GEPV, comme les microalgues ou les mycoprotéines.

  18. Effects of Breed on Milk Fatty Acid Profile in Dairy Ewes, with ...

    African Journals Online (AJOL)

    In conclusion, breed has a strong effect on the FA composition of ewe milk fat, and ... Manipulation of the fatty acid profile of milk fat with the help of dietary and ... proved beneficial to human health, contributing to a better neurological function, prevention of ... Table 1 Main characteristics of the ewes used in the experiment.

  19. Impact of energy and protein restriction on energy expenditure of gestation in twin-bearing ewes

    DEFF Research Database (Denmark)

    Kiani, Alishir; Chwalibog, Andrzej; Tauson, Anne-Helene

    2008-01-01

    This study aimed to investigate the impact of energy and protein restriction on energy expenditure of gestation (EEgest) in twin-bearing ewes. Multiparous twin-bearing ewes were fed either adequate (A: n = 10) or restricted to 60% of energy and protein requirements (R: n = 10) during the last 6...

  20. Effect of zinc from zinc sulfate on trace mineral concentrations of milk in Varamini ewes

    NARCIS (Netherlands)

    Zali, A.; Ganjkhanlou, M.

    2009-01-01

    This study was conducted to evaluate the effect of feeding supplemental zinc (zinc sulfate) in different levels (15, 30, or 45 mg/kg) on trace mineral concentrations in milk of ewes. Thirty lactating Varaminni ewes were assigned to three experimental groups according to their live body weights, milk

  1. Genetic evaluation of the probability of lambing in yearling Targhee ewes

    Science.gov (United States)

    The objective of this study was to determine the additive genetic control of lambing percentage in yearling Targhee ewes. The records of 3,103 ewe lambs born from 1989 to 2011 and mated at approximately 7.5 mo of age were analyzed. Records included sire, dam, weaning weight, breeding pen, age of dam...

  2. Ewing Marion Kauffman School Evaluation Impact Report Year 4. Final Report

    Science.gov (United States)

    Johnson, Matthew; Demers, Alicia; Johnson, Cleo Jacobs; Gentile, Claudia

    2016-01-01

    As part of its ongoing efforts to raise the academic achievement of children from low-income families in Kansas City, Missouri, the Ewing Marion Kauffman Foundation founded the Ewing Marion Kauffman School in fall 2011. The Kauffman School's mission is "to prepare students to excel academically, graduate from college, and apply their unique…

  3. Contours--Offshore of Santa Barbara, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of SIM 3281 presents data for the bathymetric contours for several seafloor maps (see sheets 1, 2, 3, 7, 10, SIM 3281) of the Offshore of Santa Barbara...

  4. La Ex Hacienda de Santa Cruz

    Directory of Open Access Journals (Sweden)

    Berta Pinto de Estrada

    1975-06-01

    Full Text Available Ex hacienda Santa Cruz was chosen to show the differences in the geographic and economic structure, and the historic causes that originated them, as an example of ihe situation in the northem part of Campeche.

  5. Folds--Offshore Santa Cruz, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the folds for the geologic and geomorphic map of the Offshore Santa Cruz map area, California. The vector data file is...

  6. Faults--Offshore Santa Cruz, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the faults for the geologic and geomorphic map of the Offshore Santa Cruz map area, California. The vector data file is...

  7. Folds--Offshore Santa Cruz, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the folds for the geologic and geomorphic map of the Offshore Santa Cruz map area, California. The vector data file is included...

  8. Folds--Offshore Santa Cruz, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the folds for the geologic and geomorphic map of the Offshore Santa Cruz map area, California. The vector data file is included...

  9. Faults--Offshore Santa Cruz, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the faults for the geologic and geomorphic map of the Offshore Santa Cruz map area, California. The vector data file is...

  10. Habitat--Offshore of Santa Barbara, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of SIM 3281 presents data for the habitat map of the seafloor (see sheet 7, SIM 3281) of the Offshore of Santa Barbara map area, California. The vector...

  11. Bathymetry--Offshore Santa Cruz, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the bathymetry and shaded-relief maps of Offshore Santa Cruz, California. The raster data file is included in...

  12. Habitat--Offshore Santa Cruz, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the habitat map of the seafloor of the Offshore of Santa Cruz map area, California. The vector data file is included in...

  13. Folds--Offshore of Santa Barbara, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of SIM 3281 presents data for folds for the geologic and geomorphic map (see sheet 10, SIM 3281) of the Offshore of Santa Barbara map area, California. The...

  14. Habitat--Offshore Santa Cruz, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the habitat map of the seafloor of the Offshore of Santa Cruz map area, California. The vector data file is included in...

  15. Bathymetry Hillshade--Offshore Santa Cruz, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the bathymetry and shaded-relief maps of Offshore Santa Cruz, California. The raster data file is included in...

  16. Contours--Offshore Santa Cruz, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the bathymetric contours for several seafloor maps of the Offshore Santa Cruz map area, California. The vector data file is...

  17. Faults--Offshore of Santa Barbara, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of SIM 3281 presents data for folds for the geologic and geomorphic map (see sheet 10, SIM 3281) of the Offshore of Santa Barbara map area, California....

  18. Folds--Offshore of Santa Barbara, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of SIM 3281 presents data for folds for the geologic and geomorphic map (see sheet 10, SIM 3281) of the Offshore of Santa Barbara map area, California....

  19. Bathymetry--Offshore Santa Cruz, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the bathymetry and shaded-relief maps of Offshore Santa Cruz, California. The raster data file is included in...

  20. Backscatter [SWATH]--Offshore Santa Cruz, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the acoustic-backscatter map of Offshore of Santa Cruz map area, California. Backscatter data are provided as three separate...

  1. Backscatter [SWATH]--Offshore Santa Cruz, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the acoustic-backscatter map of Offshore of Santa Cruz map area, California. Backscatter data are provided as three separate...

  2. Faults--Offshore of Santa Barbara, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of SIM 3281 presents data for folds for the geologic and geomorphic map (see sheet 10, SIM 3281) of the Offshore of Santa Barbara map area, California. The...

  3. Faults--Offshore of Santa Barbara, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of SIM 3281 presents data for folds for the geologic and geomorphic map (see sheet 10, SIM 3281) of the Offshore of Santa Barbara map area, California. The...

  4. Folds--Offshore of Santa Barbara, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of SIM 3281 presents data for folds for the geologic and geomorphic map (see sheet 10, SIM 3281) of the Offshore of Santa Barbara map area, California. The...

  5. Bathymetry Hillshade--Offshore Santa Cruz, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the bathymetry and shaded-relief maps of Offshore Santa Cruz, California. The raster data file is included in...

  6. Contours--Offshore Santa Cruz, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the bathymetric contours for several seafloor maps of the Offshore Santa Cruz map area, California. The vector data file is...

  7. Geology of the Curimatau medium region (Paraiba State, Brazil) and the emplacement of the Dona Ines granite associated to the Brasiliano transcurrent shear zones; Geologia da Regiao do Medio Curimatau (PB) e o alojamento do granito de Dona Ines associado a zonas de cisalhamento transcorrentes brasilianas

    Energy Technology Data Exchange (ETDEWEB)

    Borges, Sergio Vieira Freire

    1996-12-31

    In an area of about 700 Km{sup 2} located in the northeast of Paraiba State and having as main point the town of Dona Ines, a geologic/structural mapping, a gravimetric survey and radiometric dating using the Rb/Sr method in whole rock and Sm.Nd model ages were undertaken in order to study and to understand the geology of this portion of terrain, the emplacement of the Dona Ines granitoids and its relationship with the enclosing rocks and the deformation acting at the time of the intrusion. The age of the pluton of Dona Ines was determined by the Rb/Sr whole rock method as 560 {+-} 20 Ma (end of Brasiliano Cycle in the region). Sm.Nd model ages in granitoids of Araras, Belem and Dona Ines have revealed paleoproterozoic ages for their crustal sources, as indicated by the negative {epsilon}{sub nd} of this rock 128 refs., 95 figs., 6 tabs., 7 maps

  8. Estimation of milk production in hair ewes by two methods of measurement

    Directory of Open Access Journals (Sweden)

    Irina Peniche G

    2015-05-01

    Full Text Available ABSTRACT Objective. The objective of the current study was to compare two methods to estimate daily milk production in crossbred hair ewes. Materials and methods. Eight multiparous, crossbred (Pelibuey x Katahdin lactating hair ewes were used in a completely randomized design with repeated measurements, for 56 days. Ewes were fed ad libitum with a diet based on concentrate. Milk production was estimated twice a week for each ewe by both methods, suckled-hand (SH and weigh-suckle-weigh (WSW method. Results. Milk production (p>0.05 means were 031.9±95.6 and 1119.0±95.6 g/day/ewe for SH and WSW method, respectively. Conclusions. No significant differences (p>0.05 were found between methods for milk yield.

  9. Faecal particle-size distribution from ewes fed grass silages harvested at different stages of maturity

    DEFF Research Database (Denmark)

    Jalali, Alireza; Nørgaard, Peder; Nadeau, E.

    2008-01-01

    The aim of this experiment was to study the effect of maturity stage of grass at harvest on particle size in faeces from ewes fed grass silage ad libitum. Eighteen pregnant Swedish ewes bearing two foetuses were given one of three treatments as their only feed. The treatments were early (ECS), me...... pore size. The proportions of particles in the B, C, D, S and O fractions were affected by cutting time of the silaage (P size in faeces from ewes fed grass silages.......The aim of this experiment was to study the effect of maturity stage of grass at harvest on particle size in faeces from ewes fed grass silage ad libitum. Eighteen pregnant Swedish ewes bearing two foetuses were given one of three treatments as their only feed. The treatments were early (ECS...

  10. Event classification related to overflow of solvent containing uranium according to the INES scale (International Nuclear and Radiological Event Scale); Classificacao do evento de transbordamento de solvente contendo uranio segundo a escala INES (International Nuclear and Radiological Event Scale)

    Energy Technology Data Exchange (ETDEWEB)

    Dourado, Eneida R.G.; Assis, Juliana T. de; Lage, Ricardo F., E-mail: cneida@inb.gov.br, E-mail: julianateixeira@inb.gov.br, E-mail: rlage@inb.gov.br [lndustrias Nucleares do Brasil S/A (CLISE.P/INB), Rio de Janeiro, RJ (Brazil). Coordenacao de Licenciamento Nuclear e Ambiental, Saude e Seguranca; Lopes, Karina B., E-mail: karina@inb.gov.br [lndustrias Nucleares do Brasil S/A (CPRAD/INB), Rio de Janeiro, RJ (Brazil). Coordenacao de Protecao Radiologica

    2013-11-01

    This paper aims to frame the event overflow organic solvent rich in uranium, from a decanter of ore beneficiation plant, caused by the fall in the supply of electricity, according to the criteria established by the International Nuclear Event Scale and radiological (INES), facilitating the understanding of the occurrence and communication with the public regarding the radiation safety aspects involved. With the fall of electricity, routine procedures in situations of installation stop were performed, however, due to operational failure, the valve on the transfer line liquor was not closed. Thus, the mixer continued being fed with liquor, that led the consequent leakage of solvent loaded with uranium. It reached the drainage system, and the box of rainwater harvesting of the plant. However, immediately after the detection of the event, corrective actions were initiated and the overflow was contained. Regulatory agencies followed the removal of the solvent and on the results of the analysis of environmental monitoring, found that the event did not provide exposure to workers or any other impact. Therefore, comparing the characteristics of the event and the guidelines proposed by the INES scale, it is concluded that the classification of the event is below scale/level 0, confirming the absence of risk to the local population, workers and the environment.

  11. Primary Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) of the penis: a report of an extraordinarily unusual site and a literature review of extraskeletal Ewing's sarcoma.

    Science.gov (United States)

    Ma, Zheng; Brimo, Fadi; Zeizafoun, Nebras

    2013-02-01

    Ewing's sarcomas/primitive neuroectodermal tumors (ES/PNETs) arise from a multipotent progenitor cell and are considered to be of neuroectodermal derivation. Most tumors commonly arise in the skeletal system, which are the classic ES/PNET and occasionally occur in the soft tissue of extraskeletal sites, which are named extraskeletal Ewing's sarcomas (EES/PNET). This study reports a case of a 28-year-old man with primary EES/PNET of the penis.

  12. Variable expression of PIK3R3 and PTEN in Ewing Sarcoma impacts oncogenic phenotypes.

    Directory of Open Access Journals (Sweden)

    Brian F Niemeyer

    Full Text Available Ewing Sarcoma is an aggressive malignancy of bone and soft tissue affecting children and young adults. Ewing Sarcoma is driven by EWS/Ets fusion oncoproteins, which cause widespread alterations in gene expression in the cell. Dysregulation of receptor tyrosine kinase signaling, particularly involving IGF-1R, also plays an important role in Ewing Sarcoma pathogenesis. However, the basis of this dysregulation, including the relative contribution of EWS/Ets-dependent and independent mechanisms, is not well understood. In the present study, we identify variable expression of two modifiers of PI3K signaling activity, PIK3R3 and PTEN, in Ewing Sarcoma, and examine the consequences of this on PI3K pathway regulation and oncogenic phenotypes. Our findings indicate that PIK3R3 plays a growth-promotional role in Ewing Sarcoma, but suggest that this role is not strictly dependent on regulation of PI3K pathway activity. We further show that expression of PTEN, a well-established, potent tumor suppressor, is lost in a subset of Ewing Sarcomas, and that this loss strongly correlates with high baseline PI3K pathway activity in cell lines. In support of functional importance of PTEN loss in Ewing Sarcoma, we show that re-introduction of PTEN into two different PTEN-negative Ewing Sarcoma cell lines results in downregulation of PI3K pathway activity, and sensitization to the IGF-1R small molecule inhibitor OSI-906. Our findings also suggest that PTEN levels may contribute to sensitivity of Ewing Sarcoma cells to the microtubule inhibitor vincristine, a relevant chemotherapeutic agent in this cancer. Our studies thus identify PIK3R3 and PTEN as modifiers of oncogenic phenotypes in Ewing Sarcoma, with potential clinical implications.

  13. Whole-Body Radiation Therapy, Systemic Chemotherapy, and High-Dose Chemotherapy Followed By Stem Cell Rescue in Treating Patients With Poor-Risk Ewing Sarcoma

    Science.gov (United States)

    2015-01-07

    Adult Supratentorial Primitive Neuroectodermal Tumor (PNET); Ewing Sarcoma of Bone; Extraosseous Ewing Sarcoma; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor

  14. Preoperative evaluation and monitoring chemotherapy in patients with high-grade osteogenic and Ewing`s sarcoma: review of current imaging modalities

    Energy Technology Data Exchange (ETDEWEB)

    Woude, H.-J. van der; Bloem, J.L. [Department of Radiology, Leiden University Medical Centre, C2-S, P.O. Box 9600, NL-2300 RC Leiden (Netherlands); Hogendoorn, P.C.W. [Department of Pathology, Leiden University Medical Centre, Leiden (Netherlands)

    1998-02-01

    Diagnostic imaging is pivotal in the initial detection, characterization, staging and post-treatment follow-up of patients with high-grade osteogenic and Ewing`s sarcoma. In the present review article, conventional and new imaging modalities are discussed with regard to the monitoring of the effect of neoadjuvant chemotherapy in such patients. Presurgical monitoring of response to chemotherapy may have an impact on modification of neoadjuvant treatment protocols, on patient selection for the performance and timing of limb-salvage surgery and on planning of radiation therapy (in non-operated Ewing`s sarcomas) and selection of postoperative chemotherapy regimens. Dynamic contrast-enhanced MR imaging, as part of a routine MR protocol, assists in the detection of the most viable parts of the tumour and serves as an initial standard for follow-up of the metabolic activity of the tumour during and after chemotherapy, both in small intraosseous tumours and in tumours with an associated soft tissue mass. In combination with selected morphological features, dynamic imaging parameters are therefore advocated for monitoring the effect of neoadjuvant chemotherapy in patients with osteogenic and Ewing`s sarcoma. (orig.) With 9 figs., 2 tabs., 62 refs.

  15. Analysis of the Lambing Process in Suffolk Ewes

    OpenAIRE

    ŠULCOVÁ, Veronika

    2015-01-01

    The Suffolk is the most well-known of the English lowland sheep breeds. A black-faced sheep with short-stapled wool, the breed is used primarily for meat production. The Suffolk is classified as one of the breeds with the best ability to fatten and its meat yield is approximately 60%. The breed is characterised by its good adaptability to different climate and breeding conditions and overall good health. The ewes are known for their high fertility rate, shorter oestrus cycle, excellent matern...

  16. Skull-base Ewing sarcoma with multifocal extracranial metastases

    Directory of Open Access Journals (Sweden)

    Sumit Thakar

    2012-01-01

    Full Text Available Intracranial occurrence of Ewing sarcoma (ES is unusual, with a skull-base location being anecdotal. We report a 29-year-old man who presented with rapidly progressive ophthalmoplegia, and was found to be harboring an infiltrative lesion involving the sphenoid sinus, sella, and clivus. He underwent trans-sphenoidal decompression of the lesion which was histologically suggestive of ES. He developed paraparesis 2 weeks after commencing adjuvant therapy. Imaging revealed two thoracic extradural lesions and florid vertebral and pulmonary metastases. This is the first report in indexed literature of a primary intracranial ES on the skull-base with disseminated extracranial disease.

  17. A Case of Enzootic Nasal Adenocarcinoma in a Ewe

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    Devorah Marks Stowe

    2012-01-01

    Full Text Available An approximately 2-year-old open Suffolk ewe presented to the North Carolina State University College of Veterinary Medicine Veterinary Health Complex for evaluation of a left nasal mass. An ultrasound-guided aspirate and core biopsies were performed. An epithelial neoplasia with mild mixed inflammation (neutrophils and plasma cells was diagnosed on cytology and confirmed on histopathology. Immunohistochemistry (IHC, reverse transcriptase polymerase chain reaction (RT-PCR, and transmission electron microscopy were also performed. IHC and RT-PCR identified the presence of enzootic nasal tumor virus and confirmed the final diagnosis of enzootic nasal adenocarcinoma.

  18. Synchronization of ovulation and fixed time intrauterine insemination in ewes.

    Science.gov (United States)

    Deligiannis, C; Valasi, I; Rekkas, C A; Goulas, P; Theodosiadou, E; Lainas, T; Amiridis, G S

    2005-02-01

    A novel method for oestrus-ovulation synchronization in sheep followed by fixed time insemination is presented herewith. Mature dry ewes (n = 28) of Karagouniko breed being at an unknown stage of the oestrous cycle, were used during the middle of breeding season. The treatment protocol consisted of an initial administration of a GnRH analogue followed 5 days later by a prostaglandin F2alpha injection. Thirty-six hours later a second GnRH injection was administered to synchronize ovulation, and laparoscopic intrauterine insemination was performed 12-14 h later. Three days after insemination, fertile rams were introduced into the flock twice daily and oestrus-mating detection was carried out. For progesterone (P(4)) determination, blood samples were collected on alternate days, starting 2 days before the first GnRH injection and continuing for 17 days after insemination. An additional sample was taken on the day of insemination. Pregnancy diagnosis was carried out by trans-abdominal ultrasonography. Fourteen ewes (50%) conceived at insemination and maintained pregnancy; from the remainder 14 ewes 10 became pregnant at natural service, while four, although they mated at least two to three times, failed to conceive. In response to the first GnRH, P(4) concentration increased at higher levels in ewes that conceived at AI compared with those that failed to conceive (47.54 and 22.44%, respectively; p < 0.05). Significant differences (p < 0.05) in mean P(4) concentration between pregnant and non-pregnant animals were detected 1 day before AI (0.17 +/- 0.06 and 0.26 +/- 0.14 ng/ml, respectively) on the day of AI (0.15 +/- 0.04 and 0.24 +/- 0.08 ng/ml, respectively) as well as 9 and 11 days thereafter (0.48 +/- 0.12 and 0.38 +/- 0.12 ng/ml; 0.68 +/- 0.14 and 0.50 +/- 0.18 ng/ml, respectively). These results indicate that using the proposed protocol, an acceptable conception rate can be achieved which could be further improved by modifying the time intervals between

  19. Diffusion incohérente des neutrons : modèles analytiques pour la dynamique interne des protéines

    Science.gov (United States)

    Bicout, D. J.

    2005-11-01

    La dynamique interne des protéines joue un rôle central dans la stabilité, la fonction et l'activité biologique de ces biomolécules. Il est maintenant établi que les fluctuations d'états conformationnels des protéines influencent fortement la plupart des réactions biochimiques et s'accompagnent d'une augmentation brutale des déplacements carrés moyens des atomes au dessus de la température de la transition dynamique. Dans cette contribution, nous présentons une revue critique de quelques modèles théoriques couramment utilisés dans la littérature pour l'analyse des mouvements internes des protéines et la description de la transition dynamique.

  20. Estrus synchronization and artificial insemination of hair sheep ewes in the tropics.

    Science.gov (United States)

    Godfrey, R W; Collins, J R; Hensley, E L; Wheaton, J E

    1999-04-01

    Hair sheep ewes (St. Croix White and Barbados Blackbelly) were used to evaluate 3 methods of estrus synchronization for use with transcervical artificial insemination (TAI). To synchronize estrus, ewes (n = 18) were treated with PGF2alpha (15 mg, im) 10 d apart, with controlled internal drug release (CIDR) devices containing 300 mg progesterone for 12 d (n = 18), or with intravaginal sponges containing 500 mg progesterone for 12 d (n = 18). On the day of the second PGF2alpha injection or at CIDR or sponge removal, sterile rams were placed with the ewes. Jugular blood samples were collected from the ewes at 6-h intervals until the time of ovulation, and daily for 16 d after estrus (Day 0). Plasma was harvested and stored at -20 degrees C until LH, and progesterone concentrations were determined by RIA. There was no difference (P>0.10) in time to estrus among the CIDR-, PGF2alpha- or sponge-treated ewes. All of the ewes in the CIDR group and 94.4% of the sponge treated ewes exhibited estrus by 36 h after ram introduction, while only 72.2% of PGF2alpha-treated ewes showed signs of estrus by this time (P0.10) among the CIDR-, PGF2alpha- or sponge-treated ewes. The time to the preovulatory LH surge was similar (P>0.10) among CIDR, PGF2alpha and sponge treated ewes. Progesterone levels through Day 16 after the synchronized estrus were not different (P>0.10) among treatment groups. Hair sheep ewes (n = 23) were synchronized using PGF2alpha and bred by TAI using frozen-thawed semen 48 h after the second injection. The conception rate to TAI was 2/23 (8.7%) and produced 3 ram lambs. In a subsequent trial, 17 ewes were synchronized with CIDR devices and bred by TAI using frozen-thawed semen 48 h after CIDR removal, resulting in a conception rate of 52.9% (9/17). It is possible to synchronize estrus in hair sheep using either CIDRs, sponges or PGF2alpha. Even though there were no significant differences in the timing of ovulation or the LH surge among the treatment groups, a

  1. 令人陶醉的Santa Fe

    Institute of Scientific and Technical Information of China (English)

    潘小松

    1999-01-01

    假如用汉字代替Santa Fe,这个名字就失去了许多诗意。四百多年来,Santa Fe市吸引了全世界的人们。人们惊叹她的新墨西哥式的自然美,享受那里宜人的气候,赞美那丰富的西班牙和印第安文化。Santa Fe是美国最早的行政首府,也是贸易和宗教的中枢,还是音乐、建筑、美术和休闲的胜地。Santa Fe蜿蜒的小路、长着当地花草的园子和四周的山景都叫人心旷神怡。在美国没有别的城市像Santa Fe这样保护自己的文化并为之感到骄傲。她的自然美和人文传统赢得了神圣的赞誉。Santa Fe坐落在落基山脚下,每晚日落时分,这里一片鲜红,人们称之为"基督的血"。远在清教徒登陆普利茅斯之前,西班牙人就在Santa Fe建立了政府。今天,这座城市是世界旅游胜地,是美国第三大美术作品

  2. The effect of dietary restriction, pregnancy, and fetal type in different ewe types on fetal weight, maternal body weight, and visceral organ mass in ewes.

    Science.gov (United States)

    Scheaffer, A N; Caton, J S; Redmer, D A; Reynolds, L P

    2004-06-01

    Our objectives were to evaluate maternal body changes in response to dietary restriction or the increased nutrient requirement of fetal growth. In Exp. 1, 28 mature crossbred ewes (61.6 +/- 1.8 kg initial BW) were fed a pelleted forage-based diet to evaluate effects of pregnancy and nutrient restriction on visceral organ mass. Treatments were arranged in 2 x 3 factorially, with dietary restriction (60% restriction vs. 100% maintenance) and reproductive status (nonpregnant [NP], d 90 or d 130 of gestation) as main effects. Dietary treatments were begun at d 50 of gestation, and restricted ewes remained at 60% of maintenance throughout the experiment. Nonpregnant and d-90 ewes were fed dietary treatments for 40 d and slaughtered. The d-130 ewes were fed dietary treatments for 80 d and then slaughtered. In Exp. 2, four Romanov ewes were naturally mated (Romanov fetus and Romanov dam; R/ R), and two Romanov embryos were transferred to each of four Columbia recipients (Romanov embryos and Columbia recipient; R/C). Three Columbia ewes were naturally mated (Columbia fetus and Columbia recipient; C/C). In both experiments, maternal organ weights were reported as fresh weight (grams), scaled to empty body weight (EBW; grams per kilogram) and maternal body weight (MBW; grams per kilogram). In Exp. 1, ewe EBW and fetal mass were decreased (P < 0.02) with restriction compared with maintenance. Dietary restriction decreased liver mass (16.7 vs. 14.5 g/kg EBW or 18.8 vs. 16.4 g/kg MBW; P < 0.01), but dietary restriction did not affect total digestive tract mass. In Exp. 2, ewe BW was less for the R/R compared with R/C and C/C (44.8 vs. 110.4 and 98.1 +/- 7.9 kg, respectively; P < 0.01). Fetal weight at d 130 was less for the R/R than for R/C and C/C (2.2 vs. 3.3 and 4.7 +/- 0.3 kg, respectively; P < 0.01) when measured as individual fetuses; however, when measured as total fetal mass carried in each ewe, there was no effect of ewe type. These data suggest that the

  3. Peripheral blood and milk leukocytes subsets of lactating Sarda ewes

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    Piero Bonelli

    2013-05-01

    Full Text Available Leukocytes subpopulations in blood and milk of lactating Sarda ewes were investigated. Animals characterized by a SSC level <500×103cells/mL and a negative bacteriological examination were sampled in early, mid and late lactation. Milk differential cell count evidenced that macrophage represented the main population (42.8%±3.5 followed by lymphocytes (40.2%±3.4 and neutrophils (8,6%±2.1. Flow cytometry analysis showed that lymphocytes subsets in milk were quite different from blood. High CD8+ and low CD4+ lymphocytes percentages determined a CD4/CD8 ratio inversion in milk compared to blood (0.3%±0.03 vs 1.8%±0.08. CD8+ decreased while, conversely, CD4+ increased in late lactation. γδ T cells were more represented in milk (12.6%±1.3 than in blood (6.8%±0.3 and their proportions appeared similar throughout lactation in both compartments. IL-2 receptor was mainly expressed in milk on T cytotoxic lymphocytes. Data obtained in uninfected mammary glands could allow an early discrimination between physiological and pathological changes occurring in ewe milk. Further phenotypical and functional studies on milk leukocytes subsets might help to understand defense mechanisms of the ovine mammary gland against IMI.

  4. Ewe welfare and ovine milk and cheese quality

    Directory of Open Access Journals (Sweden)

    A. Sevi

    2010-04-01

    Full Text Available Causes of welfare reduction in dairy sheep flocks are presented and their impact on ovine milk and cheese quality is discussed. Attention is focused on climatic extremes, poor housing and milking hygiene, and nutritional imbalance: mechanisms are outlined through which stress-induced reduction of immune function can result in poor milk composition, deteriorated renneting ability of milk and altered proteolysis in cheese during ripening. In particular, the impact is brought out of exposure to high ambient temperature on the nutritional properties of ewe milk, in terms of increased short-chain and saturated fatty acids, and decreased unsaturated to saturated fatty acid ratio. As well, the relationship is highlighted between ewe welfare and udder health. Especially under poor hygiene conditions the risk of mastitis markedly increases due to reduction of the natural defense mechanisms of the teat and mammary gland and increased number and pathogenicity of the micro-organisms in contact with the entrance of the teat canal. Evidence is provided that rise in milk somatic cell count, in response to bacteria penetration into the udder, can lead to decreased milk yield and altered composition of milk and cheese, due to extensive epithelium secretory cell damage.

  5. Ovarian responses to undernutrition in pregnant ewes, USA

    Directory of Open Access Journals (Sweden)

    Vonnahme Kimberly A

    2003-02-01

    Full Text Available Abstract In most mammals oogonia proliferate by mitosis and begin meiotic development during fetal life. Previous studies indicated that there is a delay in the progression to the first stage of meiotic arrest in germ cells of female fetuses of undernourished ewes. We report that underfeeding (50% NRC requirement beginning on Day 28 of pregnancy provokes an increase in oxidative base lesions within DNA of mid-gestational (Day 78 fetal oogonia; this condition was associated with up-regulation of the tumor suppressor/cell-cycle arrest modulator p53, antiapoptotic factor Bcl-2, and base-excision repair polymerase β. Fetal ovarian weights and germ cell concentrations were not altered by nutrient deprivation. Ovaries of ewes on control diets (100% NRC contained more tertiary follicles than their restricted counterparts; however, peripheral venous estradiol-17β was not different between groups. There was no effect of treatment on p53 accumulation in maternal oocytes. Luteal structure-function was not perturbed by undernutrition. No fetal losses were attributed to the dietary restriction. It is proposed that DNA of interphase fetal oogonia is vulnerable to oxidative insults perpetrated by a nutritional stress to the dam, and that multiple/integrated adaptive molecular response mechanisms of cell-cycle inhibition (providing the time required for base repairs and survival hence sustain the genomic integrity and population stability of the germline.

  6. The effect of maternal nutritional status during mid-gestation on placental characteristics in ewes.

    Science.gov (United States)

    Sen, U; Sirin, E; Kuran, M

    2013-02-01

    The aim of this study was to determine the effects of maternal nutritional status during mid-gestation on placental characteristics in ewes. Time of estrus of 3-5 years old Karayaka breed ewes was synchronized and mating was monitored to determine the day 0 of gestation. The ewes had similar body weights (47.8±0.7kg) and loin eye muscle values (thickness; 20.9±1.0mm and fat thickness; 4.7±0.5mm) at mating. The ewes were allocated into two treatment groups at day 30 of gestation; under-fed (UF; n=12) and well-fed (WF; n=13) groups. The ewes in UF group were fed with a diet to provide 50% of their daily requirement from day 30 to day 80 of gestation and 100% of their daily requirement during the rest of the gestation period. The ewes in WF group were fed at least 100% of their daily requirement throughout gestation. The singleton bearing ewes in the UF group had a lesser (Ppregnancies.

  7. Macroeconomia do Turismo Argentino em Santa Catarina

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    Roberto Meurer

    2010-07-01

    Full Text Available Resumo O Estado de Santa Catarina experimentou um considerável crescimento do setor de turismo nas últimas décadas. O fluxo turístico de origem argentina revelou-se um ingrediente importante dessa trajetória. Este artigo focaliza um aspecto pouco explorado, aparentemente, da participação argentina no turismo estadual: a relação entre a situação macroeconômica do país vizinho e a demanda turística por Santa Catarina lá originada. Começa-se abordando brevemente a problemática geral da macroeconomia do turismo. Depois, discorre-se sobre o crescimento desse setor em Santa Catarina, destacando a presença de argentinos. A terceira parte desenvolve uma análise baseada em tratamento estatístico de dados sobre demanda e receita geradas por esses turistas no estado, com exame das correlações envolvendo taxa de câmbio e taxa de crescimento do PIB da Argentina. Palavras-chave: turismo; Santa Catarina; turistas argentinos; economia argentina Abstract The State of Santa Catarina has witnessed a considerable development of its tourist sector in the last decades. The demand from Argentina has proved to be an important factor of that growth. This article deals with a feature of the presence of Argentinians in the state which seems to be scarcely studied: the relationship between the macroeconomic situation of Argentina and the tourist demand in Santa Catarina originated from that country. The first part of the article considers briefly the general issue of tourism macroeconomics. The second one looks upon tourism growth in Santa Catarina, stressing the presence of visitors from Argentine. The third section develops an analysis based on statistical treatment of data concerning demand and income generated by such tourists in Santa Catarina, involving correlations that consider aspects like exchange rate and the rate of GDP increase in Argentina. Keywords: tourism; Santa Catarina; tourists from Argentina; Argentina’s economy

  8. Ingestive behavior of crossbred Santa Inês sheep fed water with different salinity levels

    Directory of Open Access Journals (Sweden)

    José Helder Andrade de Moura

    2016-04-01

    Full Text Available The objective of the present study was to evaluate the effect of four water salinity levels on the ingestive behavior of non-castrated crossbred Santa Inês sheep. Thirty-two non-castrated crossbred Santa Inês sheep in feedlot, at seven months of age and initial average weight of 21.76±1.25 kg, were used in the experiment. The experimental design was completely randomized, with four treatments and eight replicates. Four concentrations of salts in the water fed to the animals were evaluated: low (640 mg/l; medium (3,188 mg/l; high (5,740 mg/l and very high (8,326 mg/l levels of total dissolved solids (TDS. For the ingestive behaviors, the animals were observed every ten minutes, for 24 hours, to determine the time spent feeding, ruminating and idle. Also, cud chewing and the average number of defecations and urinations and the frequency of water ingestion were determined. The time spent feeding, ruminating and idle were not changed by the salinity levels in the water. Dry matter intake, neutral detergent fiber intake, total chewing time, total cud chews per day, number of daily meals, average duration of each meal and number of defecations per day did not change either. However, feeding and rumination efficiency in grams of DM/h, water intake and number of urinations were linearly affected, whereas the variables rumination efficiency in grams of NDF/h, grams of dry matter per cud, grams of neutral detergent fiber per cud, number of cuds, number of chews per cud and chewing time per cud presented quadratic effect. The different levels of total dissolved solids (640; 3,188; 5,740; and 8.326 mg/l in the water fed to the sheep did not cause alterations in their ingestive behavior. In conclusion, water with up to 8,326 mg TDS/l can be an alternative strategic and seasonal method to water crossbred Santa Ines sheep.

  9. A typical case of hydrallantois accompanied by fetal monstrosity in a local ewe of Kashmir

    Directory of Open Access Journals (Sweden)

    Hiranya Kumar Bhattacharyya

    2012-09-01

    Full Text Available A full termed local ewe with the history of continuous straining with labored breathing for last 24 hours was presented. The animal was disinclined to move with tense and round abdomen which developed rapidly during last two weeks. Caesarean section revealed hydrallantois accompanied by multiple fetal congenital abnormalities. The ewe was under observation for four weeks. Metritis developed 12 days post-operation and was treated successfully. The ewe was found active on 25 days post-surgery with gain of extra 3 kg bodyweight.

  10. Effect of Map-vaccination in ewes on body condition score, weight and Map-shedding.

    Science.gov (United States)

    Hüttner, Klim; Krämer, Ulla; Kleist, Petra

    2012-01-01

    Vaccination against Mycobacterium avium subspecies paratuberculosis (Map) in sheep receives growing attention worldwide, particularly in countries with national Map control strategies. A field study was conducted, investigating the effect of GUDAIR on body condition, weight and Map-shedding in a professionally managed but largely Map-affected suffolk flock prior and after vaccination. For this, 80 ewes out of 1000 animals were randomly sampled. In the univariate analysis body condition scores of ewes twelve months after vaccination improved significantly compared to those sampled prior to vaccination. At the same time the rate of ewes shedding Map was reduced by 37%.

  11. Extensive primary Ewings' sarcoma in the greater wing of the sphenoid bone.

    Science.gov (United States)

    Apostolopoulos, Kostas; Ferekidis, Eleftherios

    2003-01-01

    We describe a rare case of an extensive primary cranial Ewing's sarcoma located in the greater wing of the sphenoid bone with extension to the orbit, the endocranium, the parapharyngeal and infratemporal space. The patient presented with diplopia, anosmia and prolapse of the left eye. He was given chemo- and radiotherapy and was free of symptoms on re-examination 1.5 years later. The prognosis of Ewing's sarcoma in the absence of surgery is uncertain, but prompt treatment appears to have a satisfactory therapeutic outcome. In the future, more cases should be studied in order to investigate the biological behaviour of a primary cranial Ewing's sarcoma.

  12. Effects of progesterone withdrawal on uterine secretion of prostaglandin F2 alpha in response to oxytocin in ewes.

    Science.gov (United States)

    Kaminski, M A; Hayes, S H; Silvia, W J

    1997-01-01

    Two experiments were conducted to determine if withdrawal of progesterone during the luteal phase of the oestrous cycle affected the ability of the ovine uterus to secrete prostaglandin F2 alpha (PGF2 alpha) in response to oxytocin. In Experiment 1, 18 ewes were ovariectomized on Day 9 and Day 12 after oestrus. Ewes were subdivided into three treatment groups (n = 6 per group): Group-1 ewes underwent sham surgery; Group-2 ewes received oestradiol (OVX + O); and Group-3 ewes received oestradiol + progesterone (OVX + O,P). Oxytocin was administered to each ewe on Days 10, 13 and 15 after oestrus. Concentrations of 13, 14-dihydro-15-keto-PGF2 alpha (PGFM) were determined in samples of jugular venous blood for 2 h after oxytocin challenge. The magnitude of the PGFM response 24 h after ovariectomy was greater (P Day 11 and assigned to 1 of 4 treatment groups (n = 6 per group): Group 1, no steroid replacement (OVX); Group 2, oestradiol replacement (OVX + O); Group 3, progesterone replacement (OVX + P); or Group 4, progesterone + oestradiol replacement (OVX + O,P). Ewes received oxytocin on Day 12 and Day 15. On Day 12, uterine secretory responsiveness to oxytocin was greatest in ewes in the OVX + O group (P < 0.1). Responsiveness was low in ewes in the OVX group, as it was in ewes in both groups that received progesterone replacement. Therefore, the increase in uterine secretory responsiveness to oxytocin following progesterone withdrawal is dependent on oestradiol replacement.

  13. Comportamento de ovinos da raça Santa Inês, de diferentes pelagens, em pastejo = Behavior of Santa Inês sheep, different colorations, grazing

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    Merilene Maria dos Santos

    2011-07-01

    Full Text Available O objetivo deste experimento foi avaliar o comportamento de ovinos da raça Santa Inês, de diferentes pelagens em condições de pastejo. O delineamento experimental foi o inteiramente casualizado, com três cores de pelame (branco, castanho e preto, representando os tratamentos e 7 repetições, em um arranjo de parcela subdividida com cor do pelame na parcela e período na sub-parcela. As observações das variáveis analisadas foram realizadas em quatro períodos experimentais, onde cada período conteve três dias de observações comportamentais. Sendo as variáveis analisadas: tempo de pastejo, tempo de ruminação, tempo em ócio, outras atividades e bebendo água. As observações foram realizadas a cada 10 min., das 6 às 17h. Não houve interação significativa (p > 0,05 entre período e cor do pelame para nenhuma das características comportamentais estudadas. Osperíodos influenciaram todas as atividades comportamentais. A cor do pelame influenciou na atividade ruminando em pé ao sol: animais brancos apresentaram maior tempo (p The objective of this experiment was to evaluate the behavior in Santa Ines sheep, different colorations, under conditions of grazing. The experimental design was completely randomized, with three coat colors (white, brown and black as treatments and 7 replications in a split plot arrangement with the coat color in the plot and period in the sub-plot. The observations of the variables analyzed were four experimental periods where each period contained three days of behavioral observations. Since the variables: grazing time, rumination time, leisure time, drinking water and other activities The observations were made every 10 minutes from 6 a.m. to 5 p.m. No significant interaction (p > 0.05 between period and color of the coat for any of the behavioral traits studied. The periods affected all behavioral activities. The hair coat color influenced the activity mulling standing at the Sun, the white animals

  14. Primary Ewing's sarcoma of the vertebral column

    Energy Technology Data Exchange (ETDEWEB)

    Ilaslan, Hakan; Sundaram, Murali [Department of Radiology, Mayo Clinic, Ch2-290 200 First Street, SW, Rochester, 55905, MN (United States); Unni, K.Krishnan [Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, 55905, Rochester, MN (United States); Dekutoski, Mark B. [Department of Orthopedic Surgery, Mayo Clinic, 200 First Street, SW, 55905, Rochester, MN (United States)

    2004-09-01

    To determine the demographics, imaging findings, clinical symptoms, and prognosis of primary vertebral Ewing's sarcoma (PVES). A retrospective review of medical records and radiological studies of patients diagnosed with PVES from 1936 through 2001 in our institution and Department of Pathology consultation files was undertaken. Metastatic and soft tissue Ewing's sarcoma cases were excluded. From a total of 1,277 cases of Ewing's sarcoma, 125 (9.8%) had a primary vertebral origin. There were 48 females and 76 males. Patient ages ranged from 4 to 54 (mean 19.3, standard deviation 10.7, median 16) years. Vertebral column distribution was four cervical (3.2%), 13 thoracic (10.5%), 31 lumbar (25%), and 67 sacrum (53.2%). More than one vertebral segment was involved in ten cases (8%). Satisfactory imaging studies were available in 51 patients: 49 radiographs, 27 computerized tomography (CT), and 23 magnetic resonance imaging (MRI) studies. The majority of tumors were lytic (93%). Three cases were mixed lytic and sclerotic (6%) and one sclerotic. In the nonsacral spine, the majority of lesions (12/20) involved the posterior elements with extension into the vertebral body. Five cases were centered in the vertebral body with extension into the posterior elements. Two cases were limited to the posterior elements, and one case solely involved the vertebral body. Ala was the most frequently affected site in the sacrum (18/26). Spinal canal invasion was frequent (91%). Detailed clinical information was available in 53 patients. Duration of symptoms ranged from 1 to 30 (mean 7) months. Local pain was the first symptom and seen in all cases. Neurological deficits were present in 21 (40%) cases. All patients received radiation in various dosages; 70% additionally received chemotherapy. Twenty-five patients had surgery, and two patients received bone marrow transplantation. Forty-five patients had follow-up; the five-year disease-free survival probability is 0

  15. Effect of season and mating system in Awassi ewes superovulated with FSH on fertilization rate and embryo recovery

    Directory of Open Access Journals (Sweden)

    M. K. M. A. Al-Mola

    2010-01-01

    Full Text Available The aim of the present study was to evaluate the contribution of laparoscopic intrauterine insemination to the improvement of fertilization and embryo recovery in Awassi ewes superovulated with FSH in breeding and non-breeding season. Twelve nonpregnant and cycling Awassi ewes of 3-4 years of age were randomly allocated in equal numbers (n = 6 to two groups. Each ewe was treated with a progesterone impregnated intravaginal sponge for 12 days. All ewes were superovulated with FSH in eight reducing doses for four days in the morning and evening from two days prior to sponge withdrawal. Ewes of group 1 were mated naturally at least two times with Awassi rams of proven fertility. Ewes of group 2 had intrauterine insemination and were conducted 44-46 h after sponge removal, under laparoscopic visualization of uterine horns, depositing 1 ml of semen in the distal portion of each uterine horn. Ovarian response was assessed by determining number of corpora lutea by laparoscopy on day 6 after mating. Embryo recovery was performed by hand assisted laparoscopy and by flushing both uterine horns. Ovarian response of the ewes superovulated with FSH was decreased to half in the non-breeding season. High number of unfertilized ova (P<0.05 was observed in ewes superovulated with FSH in the non-breeding season when naturally inseminated compared to ewes inseminated intrauterine using laparoscopic technique. Higher rates of embryo recovery (P<0.05 were achieved in superovulated ewes in the breeding season when ewes were inseminated by laparoscopic intrauterine insemination. The fertilization rates in ewes inseminated intrauterine using laparoscopic techniques in breeding season and non-breeding season were 88.1% and 37.98%, respectively. It could be concluded from the results of the present study that the use of FSH to induce superovulation in Awassi ewes combined with laparoscopic intrauterine insemination can increase the fertilization rate in the breeding

  16. Pyridox(am)ine-5-Phosphate Oxidase Deficiency Treatable Cause of Neonatal Epileptic Encephalopathy With Burst Suppression: Case Report and Review of the Literature.

    Science.gov (United States)

    Guerin, Andrea; Aziz, Aly S; Mutch, Carly; Lewis, Jillian; Go, Cristina Y; Mercimek-Mahmutoglu, Saadet

    2015-08-01

    Pyridox(am)ine-5-phosphate oxidase deficiency is an autosomal recessive disorder of pyridoxine metabolism. Intractable neonatal epileptic encephalopathy is the classical presentation. Pyridoxal-5-phosphate or pyridoxine supplementation improves symptoms. We report a patient with myoclonic and tonic seizures at the age of 1 hour. Pyridoxal-5-phosphate was started on the first day of life and seizures stopped at the age of 3 days, but encephalopathy persisted for 4 weeks. She had normal neurodevelopmental outcome at the age of 12 months on pyridoxal-5-phosphate monotherapy. She had novel homozygous pathogenic frameshift mutation (c.448_451del;p.Pro150Argfs*27) in the PNPO gene. Long-lasting encephalopathy despite well-controlled clinical seizures does neither confirm nor exclude pyridox(am)ine-5-phosphate oxidase deficiency. Normal neurodevelopmental outcome of our patient emphasizes the importance of pyridoxal-5-phosphate treatment. Pyridox(am)ine-5-phosphate oxidase deficiency should be included in the differential diagnosis of Ohtahara syndrome and neonatal myoclonic encephalopathy as a treatable underlying cause. In addition, we reviewed the literature for pyridox(am)ine-5-phosphate oxidase deficiency and summarized herein all confirmed cases.

  17. UTJECAJ DUŽINE TRANSPORTA I MIJEŠANJA GRUPA NA KAKVOĆU JUNEĆIH TRUPOVA SIMENTALSKIH BIKOVA

    OpenAIRE

    Marenčić, Dean; A. Ivanković, Ante; Pintić, Vinko; Horvat-Marković, R.; Horvat, M.; Konjačić, M.; Kelava, N.

    2010-01-01

    Proizvođači junećega mesa proteklih godina imaju značajne probleme u plasmanu junetine, prvenstveno zbog učestalije pojave tamnog suhog i tvrdog mesa (DFD). Potrošači takvo meso nerado kupuju i konzumiraju. Cilj ovog istraživanja je utvrditi značajnost utjecaja dužine transporta i miješanja grupa bikova tijekom odmora u stočnom depou na kakvoću junećih trupova. Istraživanje je uključilo 40 simentalske junadi u dobi od 18 do 20 mjeseci. Mjerenje konačne pH vrijednosti i boje mesa vršena su 24 ...

  18. 78 FR 66982 - Santa Clara Pueblo Disaster #NM-00039

    Science.gov (United States)

    2013-11-07

    ... ADMINISTRATION Santa Clara Pueblo Disaster NM-00039 AGENCY: U.S. Small Business Administration. ACTION: Notice... for the Santa Clara Pueblo (FEMA- 4151-DR), dated 10/29/2013. Incident: Severe Storms and Flooding... disaster: Primary Areas: Santa Clara Pueblo. The Interest Rates are: Percent For Physical Damage:...

  19. 27 CFR 9.126 - Santa Clara Valley.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Santa Clara Valley. 9.126... Santa Clara Valley. (a) Name. The name of the viticultural area described in this section is “Santa Clara Valley.” (b) Approved Maps. The appropriate maps for determining the boundaries of the...

  20. Primary Ewing's Sarcoma of the Kidney in a 73-Year-Old Man.

    Science.gov (United States)

    Wedde, T B; Lobmaier, I V K; Brennhovd, B; Lohne, F; Hall, K S

    2011-01-01

    Objective. Ewing's sarcoma of the kidney is rare and is usually found in young adults. We present here a single case study of Ewing's sarcoma found in an elderly man. Material and methods. A 73-year-old man underwent routine surgery for hydrocoele of the testis. He developed urinary obstruction symptoms, and radiological examinations revealed a tumour in the right kidney. Results. Microscopical, immunohistochemical, and molecular pathological analysis of the tumour was consistent with Ewing's sarcoma. FISH showed rearrangement of chromosomes 22q12 (EWSR1). The patient subsequently underwent nephrectomy followed by 6 adjuvant chemotherapy cycles. Follow-up after 7 months shows no recurrence. Conclusion. This case report presents not only the rare finding of Ewing's sarcoma in the kidney, but also the occurrence of this tumour entity in an elderly patient. Treatment options for the different types of renal tumours are vastly different and the need for a correct diagnosis is, therefore, vital.

  1. Influence of growth hormone on growth and onset of puberty of Rahmani ewe lamb

    Directory of Open Access Journals (Sweden)

    K.H. El-Shahat

    2014-09-01

    Conclusion: Somatotropin administration enhanced puberty in Rahmani ewe lambs. This is due to increased provision of trophic signals (represented by increased Serum IGF-1 secretions and/or blood-borne metabolites (glucose, cholesterol and lipid.

  2. Relationship between energy intake and chewing index of diets fed to pregnant ewes

    DEFF Research Database (Denmark)

    Nielsen, Mette Vestergaard; Nadeau, E.; Markussen, Bo

    2015-01-01

    The objective was to determine whether a linear relationship exists between the metabolizable energy (ME) intake of pregnant ewes and a dietary chewing index (CI). The relationship was studied using five feeding trials with intake data from 108 pregnant ewes, 4 to 1 weeks before lambing, giving...... a total of 324 observations. All ewes were fed grass silage ad libitum, supplemented with concentrates either separately or in a total mixed ration (TMR). The ewes were of different breeds, were between 2 and 7 years old, had a mean body weight (BW) in the 4th week before lambing of 95.1 kg (SD = 9...... × ME02 × CIcor, where MEI is the daily metabolizable energy intake, ME0 is considered the theoretical maximum intake capacity of the animal in a theoretical situation with no physical constraint on intake, and parameter k represents the decline in MEI with the increasing CIcor of the ration. The model...

  3. The importance of PET/CT in the evaluation of patients with Ewing tumors

    Energy Technology Data Exchange (ETDEWEB)

    Guimaraes, Julio Brandao; Rigo, Leticia; Lewin, Fabio; Emerick, Andre, E-mail: juliobrandaoguimaraes@hotmail.com [Hospital Sao Jose-Beneficincia Portuguesa de Sao Paulo, SP (Brazil)

    2015-05-15

    The effective evaluation for the treatment of patients with Ewing tumors depends on the accuracy in the determination of the primary tumor extent and the presence of metastatic disease. Currently, no universally accepted staging system is available to assess Ewing tumors. The present study aimed at discussing the use of PET/CT as a tool for staging, restaging and assessment of therapeutic response in patients with Ewing tumors. In spite of some limitations of PET/CT as compared with anatomical imaging methods, its relevance in the assessment of these patients is related to the capacity of the method to provide further physiological information, which often generates important clinical implications. Currently, the assessment of patients with Ewing tumor should comprise a study with PET/CT combined with other anatomical imaging modalities, such as radiography, computed tomography and magnetic resonance imaging. (author)

  4. Ten-Year Follow-Up of a Patient with Metastatic Ewing's Sarcoma of the Pelvis

    Directory of Open Access Journals (Sweden)

    Robert U. Ashford

    2002-01-01

    Full Text Available Patient: We report a 32-year-old women with a pelvic Ewing's sarcoma, who developed skeletal metastases within 20 months of diagnosis but following treatment remains disease-free at 10 years.

  5. Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma

    Science.gov (United States)

    2017-03-27

    Metastatic Ewing Sarcoma; Metastatic Malignant Neoplasm in the Bone; Metastatic Malignant Neoplasm in the Bone Marrow; Metastatic Malignant Neoplasm in the Lung; Metastatic Peripheral Primitive Neuroectodermal Tumor of Bone; Peripheral Primitive Neuroectodermal Tumor of Soft Tissues

  6. reducing the partum.to-mating period in autumn lactating ewes ...

    African Journals Online (AJOL)

    both progesterone and PMSG. Of the progestagens and ... In the lactating ewe progesterone therapy soon ... oestrogen to trigger the release of LH and induce oestrus is precluded in ... birth (singles or twins) into five groups (Fig. l) each of.

  7. HEALTH AND HYGIENIC CONDITIONS OF EWE'S MILK PROCESSING FROM THE ASPECT OF FOOD SAFETY

    Directory of Open Access Journals (Sweden)

    Jana Pukáčová

    2010-07-01

    Full Text Available Totally, 47 strains of S. aureus and 578 coagulase negative staphylococci were detected in samples from raw ewe milk. The 35 out 47 isolates of S. aureus from ewe milk were positive for the presence of staphylococcal enterotoxin genes: sea(4 %, sec (48 % a sed (48 %. Staphylococcus epidermis (33.04%, Staphylococcus caprae (21.28% were more prevalent. Staphylococcus chromogenes (7.44 %, Staphylococcus hominis (7.09%, Staphylococcus xylosus (6,92 %, a Staphylococcus warneri (6.40 % were isolated also in ewes milk. Staphylococcus haemolyticus (3.11 %, Staphylococcus capitis (2.94 %, Staphylococcus simulans (2.08 % and Staphylococcus saprophyticus (1.73 % were isolated very rarely from the taken individual milk ewe samples. Sporadically, only in few cases, the others coagulase negative staphylococci were isolated (Staphylococcus cohnii cohnii, Staphylococcus sciuri, Staphylococcus closii, Staphylococcus lugdunensis, Staphylococcus auricularis and Staphylococcus equorum.   doi:10.5219/24

  8. The importance of PET/CT in the evaluation of patients with Ewing tumors

    Directory of Open Access Journals (Sweden)

    Júlio Brandão Guimarães

    2015-06-01

    Full Text Available Abstract The effective evaluation for the treatment of patients with Ewing tumors depends on the accuracy in the determination of the primary tumor extent and the presence of metastatic disease. Currently, no universally accepted staging system is available to assess Ewing tumors. The present study aimed at discussing the use of PET/CT as a tool for staging, restaging and assessment of therapeutic response in patients with Ewing tumors. In spite of some limitations of PET/CT as compared with anatomical imaging methods, its relevance in the assessment of these patients is related to the capacity of the method to provide further physiological information, which often generates important clinical implications. Currently, the assessment of patients with Ewing tumor should comprise a study with PET/CT combined with other anatomical imaging modalities, such as radiography, computed tomography and magnetic resonance imaging.

  9. Targeting the DNA repair pathway in Ewing sarcoma.

    Science.gov (United States)

    Stewart, Elizabeth; Goshorn, Ross; Bradley, Cori; Griffiths, Lyra M; Benavente, Claudia; Twarog, Nathaniel R; Miller, Gregory M; Caufield, William; Freeman, Burgess B; Bahrami, Armita; Pappo, Alberto; Wu, Jianrong; Loh, Amos; Karlström, Åsa; Calabrese, Chris; Gordon, Brittney; Tsurkan, Lyudmila; Hatfield, M Jason; Potter, Philip M; Snyder, Scott E; Thiagarajan, Suresh; Shirinifard, Abbas; Sablauer, Andras; Shelat, Anang A; Dyer, Michael A

    2014-11-06

    Ewing sarcoma (EWS) is a tumor of the bone and soft tissue that primarily affects adolescents and young adults. With current therapies, 70% of patients with localized disease survive, but patients with metastatic or recurrent disease have a poor outcome. We found that EWS cell lines are defective in DNA break repair and are sensitive to PARP inhibitors (PARPis). PARPi-induced cytotoxicity in EWS cells was 10- to 1,000-fold higher after administration of the DNA-damaging agents irinotecan or temozolomide. We developed an orthotopic EWS mouse model and performed pharmacokinetic and pharmacodynamic studies using three different PARPis that are in clinical development for pediatric cancer. Irinotecan administered on a low-dose, protracted schedule previously optimized for pediatric patients was an effective DNA-damaging agent when combined with PARPis; it was also better tolerated than combinations with temozolomide. Combining PARPis with irinotecan and temozolomide gave complete and durable responses in more than 80% of the mice.

  10. Glutathione peroxidase (GPX activity in blood of ewes on farms in different scrapie categories in Iceland

    Directory of Open Access Journals (Sweden)

    Eiríksson Tryggvi

    2008-06-01

    Full Text Available Abstract Background Preliminary studies indicated decreased glutathione peroxidase (GPX activity in blood of ewes on scrapie-afflicted farms. Other studies have shown decreased GPX activity in brain of prion-infected mice and in prion-infected cells in vitro. The aim of this study was to examine the GPX activity in blood as well as the distribution of GPX-activity levels from ewes on farms in scrapie-afflicted areas in Iceland. Methods Blood samples were collected from 635 ewes (non-pregnant [n = 297] and pregnant [n = 338] on 40 farms in scrapie-afflicted areas during the years 2001–2005, for analysis of GPX activity. The farms were divided into three categories: 1. Scrapie-free farms (n = 14; 2. Scrapie-prone farms (earlier scrapie-afflicted, restocked farms (n = 12; 3. Scrapie-afflicted farms (n = 14. For comparison, 121 blood samples were also collected from non-pregnant ewes on one farm (farm A in a scrapie-free area (scrapie never registered. Chi-square test was used to test for normal distribution of GPX-results, and Kruskal-Wallis test to compare GPX-results between categories. Results The GPX-results appeared to be biphasically distributed in ewes in all three scrapie categories and on farm A. The presumptive breaking point was about 300 units g Hb-1. About 30–50% of the GPX-results from ewes in all three scrapie categories were below 300 units g Hb-1 but only about 13% of the GPX-results from ewes on farm A. The mean GPX activity was highest on farm A, and was significantly lower on scrapie-prone farms than on scrapie-free or scrapie-afflicted farms (non-pregnant and pregnant ewes: P Conclusions 1 the distribution of GPX-results in blood of Icelandic ewes apparently has a biphasic character; 2 the GPX-results were higher in ewes on one farm in a scrapie-free area than in ewes on farms in the scrapie-afflicted areas; 3 GPX-activity levels were significantly lowest on earlier scrapie-afflicted, restocked farms, which might have a

  11. Central and peripheral oxytocin profiles during milking in ewes

    Directory of Open Access Journals (Sweden)

    João Carlos Bochini

    2014-08-01

    Full Text Available The present work investigated the possible relationship between central and peripheral oxytocin (OT release during milking in experimental ewes. Ten multiparous ewes were divided into four groups according to milk ejection stimuli: exclusive machine milking (EM, mixed-management milking and suckling, lambs separated during the night and reunited with their mother after morning milking (MMS; mixed-management with manual milking (MMM, and exclusive suckling (ES lambs also separated during the night. Simultaneous sampling of cerebrospinal fluid (CSF and blood was performed during milking. The means, standard deviations, variation coefficients, and minimum and maximum CSF and plasma OT concentrations were the following, respectively: 257.88 ± 265.90 pg/ml, 103.11%, and 11.70 and 1000.00 pg/ml. No statistically significant correlations were found between OT concentrations in the CSF and plasma samples (EM: -0.26; ES: -0.19; MMM: 0.05; MMS: 0.04. The OT concentration in CSF was not influenced by milk ejection stimuli, although plasma OT was higher in the MMM (679.80 ± 25.63 and MMS (591.82 ± 30.56 groups compared with the EM and ES groups. Additionally, plasma OT concentrations were higher in the OME group (381.04 ± 22.09 compared with the AE group (218.82 ± 27.04. In conclusion, no positive correlations were found between central and peripheral OT concentrations during milking and suckling. Plasma OT concentrations differed as a function of milking management and had consequences for both milk ejection and production. Plasma but not CSF oxytocin concentrations were influenced by different milk ejection stimuli.

  12. Effect of ewe and lamb genotype on gestation length, lambing ease and neonatal behaviour of lambs.

    Science.gov (United States)

    Dwyer, C M; Lawrence, A B; Brown, H E; Simm, G

    1996-01-01

    To distinguish between ewe and lamb breed effects on prenatal growth, ease of parturition and early lamb behaviour, an embryo-transfer study was carried out using a hill breed (Scottish Blackface; liveweight: 54.25 +/- 1.03 kg, mean +/- s.e.m.) and a lowland breed (Suffolk; 80.33 +/- 1.52 kg) to obtain the four possible combinations of ewe and lamb. Data were collected from 38 Blackface ewes (18 with Blackface lambs and 20 with Suffolk lambs) and 41 Suffolk ewes (20 with Blackface lambs and 21 with Suffolk lambs); all ewes were given single embryos. Suffolk lambs had a significantly longer gestation than Blackface lambs (1.5 days, P < 0.01), regardless of ewe breed. Suffolk lambs also had a longer labour (20 min, P < 0.05) and were significantly more likely to require birth assistance (17/21, 81% of all assisted deliveries; P < 0.001), as were male lambs (19/21, 90%; P < 0.01). These variables were independent of ewe breed. Blackface lambs were significantly more active than Suffolk lambs in the first 2 h after birth; ewe breed had little effect on lamb behaviour. Blackface lambs stood twice as quickly as Suffolk lambs after birth (13 min v. 24 min; P < 0.001), and were significantly more likely to suckle within the first 2 h after birth (92% v. 66%; P < 0.05). The behavioural retardation of Suffolk lambs may be a consequence of their birth difficulty which increases their likelihood of suffering birth trauma and hypoxia at parturition. Together, these factors may increase the probability of neonatal death in these lambs.

  13. RNA helicase DDX3: a novel therapeutic target in Ewing sarcoma.

    Science.gov (United States)

    Wilky, B A; Kim, C; McCarty, G; Montgomery, E A; Kammers, K; DeVine, L R; Cole, R N; Raman, V; Loeb, D M

    2016-05-19

    RNA helicase DDX3 has oncogenic activity in breast and lung cancers and is required for translation of complex mRNA transcripts, including those encoding key cell-cycle regulatory proteins. We sought to determine the expression and function of DDX3 in sarcoma cells, and to investigate the antitumor activity of a novel small molecule DDX3 inhibitor, RK-33. Utilizing various sarcoma cell lines, xenografts and human tissue microarrays, we measured DDX3 expression at the mRNA and protein levels, and evaluated cytotoxicity of RK-33 in sarcoma cell lines. To study the role of DDX3 in Ewing sarcoma, we generated stable DDX3-knockdown Ewing sarcoma cell lines using DDX3-specific small hairpin RNA (shRNA), and assessed oncogenic activity. DDX3-knockdown and RK-33-treated Ewing sarcoma cells were compared with wild-type cells using an isobaric mass-tag quantitative proteomics approach to identify target proteins impacted by DDX3 inhibition. Overall, we found high expression of DDX3 in numerous human sarcoma subtypes compared with non-malignant mesenchymal cells, and knockdown of DDX3 by RNA interference inhibited oncogenic activity in Ewing sarcoma cells. Treatment with RK-33 was preferentially cytotoxic to sarcoma cells, including chemotherapy-resistant Ewing sarcoma stem cells, while sparing non-malignant cells. Sensitivity to RK-33 correlated with DDX3 protein expression. Growth of human Ewing sarcoma xenografts expressing high DDX3 was inhibited by RK-33 treatment in mice, without overt toxicity. DDX3 inhibition altered the Ewing sarcoma cellular proteome, especially proteins involved in DNA replication, mRNA translation and proteasome function. These data support further investigation of the role of DDX3 in sarcomas, advancement of RK-33 to Ewing sarcoma clinical trials and development of RNA helicase inhibition as a novel anti-neoplastic strategy.

  14. Stereotactic Body Radiotherapy for Metastatic and Recurrent Ewing Sarcoma and Osteosarcoma

    OpenAIRE

    Brown, Lindsay C.; Lester, Rachael A.; Grams, Michael P.; Haddock, Michael G.; Olivier, Kenneth R.; Arndt, Carola A S; Rose, Peter S.; Laack, Nadia N.

    2014-01-01

    Background. Radiotherapy has been utilized for metastatic and recurrent osteosarcoma and Ewing sarcoma (ES), in order to provide palliation and possibly prolong overall or progression-free survival. Stereotactic body radiotherapy (SBRT) is convenient for patients and offers the possibility of increased efficacy. We report our early institutional experience using SBRT for recurrent and metastatic osteosarcoma and Ewing sarcoma. Methods. We reviewed all cases of osteosarcoma or ES treated with ...

  15. MR findings of primary Ewing's sarcoma of greater wing of sphenoid.

    Science.gov (United States)

    Singh, Paramjeet; Jain, Manoj; Singh, D P; Kalra, Naveen; Khandelwal, N; Suri, S

    2002-12-01

    Primary Ewing's sarcoma of the skull is a very rare entity. We report MRI findings in a case of Ewing's sarcoma of the greater wing of sphenoid in a 4-year-old patient. Magnetic resonance imaging showed markedly heterogenous signal intensity with areas of haemorrhage and necrosis. It also demonstrated the exact extent of tumour due to its multiplanar capabilities and was, therefore, helpful in planning surgery.

  16. Effects of residual feed intake classification and method of alfalfa processing on ewe intake and growth.

    Science.gov (United States)

    Redden, R R; Surber, L M M; Grove, A V; Kott, R W

    2014-02-01

    The objective of this research was to evaluate the effects of residual feed intake (RFI) determined under ad libitum feeding conditions on DMI and performance of yearling ewes fed either chopped or pelleted alfalfa hay. In Exp. 1, 45 ewe-lambs had ad libitum access to a pelleted grower diet for 63 d and individual DMI was determined using an electronic feed delivery system. Residual feed intake values were assigned to each ewe-lamb as a measure of feed efficiency. Sixteen ewe-lambs with the most positive RFI values were classified as high RFI (inefficient) and 16 ewe-lambs with the most negative RFI values were classified as low RFI (efficient). In Exp. 2, half of the ewes from each efficiency group were placed into 1 of 2 pens and provided ad libitum access to either pelleted or chopped alfalfa hay. Individual DMI was again determined using an electronic feed delivery system. Body weight, LM area (LMA), and 12th-rib back fat thickness (BF) were measured at the beginning and end of both experiments. In Exp. 1, DMI by ewe-lambs in the low RFI group was 9% less (P = 0.01) than by ewe-lambs in the high RFI group (2.21 vs. 2.43 kg/d); however, ADG and initial and final BW, LMA, and BF did not differ (P > 0.27) among RFI groups. In Exp. 2, there were no feed processing × RFI group interactions (P > 0.14) for any trait. By design, RFI values were lower (P intake was 22% less (P 0.45) between RFI groups but were greater (P intake and efficiency were more apparent when alfalfa was pelleted.

  17. Effect of undernutrition in foetal life on energy expenditure during gestation in ewes

    DEFF Research Database (Denmark)

    Kiani, Alishir; Chwalibog, André; Tygesen, Malin P;

    2008-01-01

    The long-term effect of early life undernutrition on late gestation energy expenditure (EEgest) was investigated in sheep. Ewes were fed either adequate (100%) or restricted (60%) energy and protein during late foetal life as well as during last trimester of gestation later in life, resulting in ...... nutrient restriction in early life impairs the ability of ewes to respond to nutritional restriction in terms of energy expenditure of gestation....

  18. Diagnosis of subclinical mastitis in Santa Inês and Morada Nova sheep in southeastern Brazil.

    Science.gov (United States)

    Zafalon, Luiz Francisco; Santana, Raul Costa Mascarenhas; Pilon, Lucas Eduardo; Júnior, Guilherme Aparecido Fim

    2016-06-01

    The objective of this study was to evaluate different screening limits for the California mastitis test (CMT) and the somatic cell count (SCC) in previous diagnoses of subclinical mastitis in Santa Inês and Morada Nova ewes, which were reared under the same management conditions. Additionally, cutoff points were defined for SCC in accordance with the sensitivity and specificity of the test. A total of 907 mammary halves were subjected to CMT and SCC. The disease was confirmed by means of microbiological identification. Coagulase-negative staphylococci (CNS) were the microorganisms with highest occurrence. The CMT score of 1+ provided adequate sensitivity and specificity at all periods of lactation investigated. This score showed good agreement with SCC, >400,000 cells mL(-1). Higher cell counts favored higher diagnostic specificity. They can be used when producers have financial difficulties relating to treatment or culling of sheep with subclinical mastitis. However, producers should be warned about the risk of false-negative results in the flock.

  19. Contours--Offshore of Santa Barbara, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of SIM 3281 presents data for the bathymetric contours for several seafloor maps (see sheets 1, 2, 3, 7, 10, SIM 3281) of the Offshore of Santa Barbara map...

  20. Santa Legends From Around the World

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The tradition of children receiving gifts during the month of December is relatively the same no matter where you go in the world, but the character that brings the gifts can vary quite a bit from country to country. The following are the top five Santa legends from around the world.

  1. Ecotourism: The Santa Elena Rainforest Project.

    Science.gov (United States)

    Wearing, Stephen

    1993-01-01

    Describes an ecotourism project in which the community of Santa Elena, Costa Rica, are developing a rainforest reserve on government land leased permanently to the local high school. Discusses the impact of the project on the community's economy and environment. (Contains 30 references.) (MDH)

  2. Bathymetry--Offshore of Santa Barbara, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of SIM 3281 presents data for the bathymetry and shaded-relief maps (see sheets 1, 2, SIM 3281) of the Offshore of Santa Barbara map area, California. The...

  3. Santa Fe Junior College, Gainesville, Florida.

    Science.gov (United States)

    Caudill, Rowlett and Scott, Architects, Houston, TX.

    The design of Santa Fe Junior College is examined, beginning with the development of an educational philosophy. Subsequent design decisions are based largely upon this philosophy which emphasizes the development of the individual student and the fulfillment of his needs. Further, the need for flexibility is recognized and is an important aspect of…

  4. Hyperspectral Ocean Color Science: Santa Barbara Channel

    Science.gov (United States)

    2016-06-07

    goal of the PnB in situ sampling program is to develop state-of-the- art ocean color algorithms for Case II waters like those found in the Santa Barbara...S.Maritorena and W. Robinson, 1999: Atmospheric correction of satellite ocean color imagery: The black pixel assumption. Submitted to Applied Optics. Toole

  5. Production performance and plasma metabolites of dairy ewes in early lactation as affected by chitosan

    Energy Technology Data Exchange (ETDEWEB)

    Garcia-Rodriguez, A.; Arranz, J.; Mandaluniz, N.; Beltrán-de-Heredia, I.; Ruiz, R.; Goiri, I.

    2015-07-01

    The objective of this study was to evaluate the effects of chitosan (CHI) supplementation on production performance and blood parameters in dairy ewes. Twenty-four multiparous Latxa dairy ewes at d 16 of lactation were divided into two groups of 12 ewes each. Ewes were fed one of two experimental concentrates (0.840 kg dry matter/d), control or supplemented with 1.2% CHI, on a dry matter basis. Ewes also had free access to tall fescue hay, water, and mineral salts. The experimental period lasted for 25 d, of which the first 14 d were for treatment adaptation and the last 11 d for measurements and samplings. Supplementation with CHI decreased total (p=0.043) and fescue (p=0.035) dry matter intake (DMI), but did not affect concentrate DMI. Supplementation with CHI, moreover, increased plasma glucose (p=0.013) and BUN concentrations (p=0.035), but did not affect those of non-esterified fatty acids. Dietary supplementation with CHI, however, did not affect milk yield, 6.5% FCM, milk composition, or BW, but it improved dietary apparent efficiency by increasing the milk yield-to-DMI (p=0.055) and 6.5% FCM-to-DMI (p=0.045) ratios. In conclusion, dietary supplementation of chitosan maintained ewe performance while reducing feed intake and improving dietary apparent efficiency. (Author)

  6. EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma

    Science.gov (United States)

    Cidre-Aranaz, Florencia; Alonso, Javier

    2015-01-01

    Ewing sarcoma is an aggressive bone malignancy that affect children and young adults. Ewing sarcoma is the second most common primary bone malignancy in pediatric patients. Although significant progress has been made in the treatment of Ewing sarcoma since it was first described in the 1920s, in the last decade survival rates have remained unacceptably invariable, thus pointing to the need for new approaches centered in the molecular basis of the disease. Ewing sarcoma driving mutation, EWS–FLI1, which results from a chromosomal translocation, encodes an aberrant transcription factor. Since its first characterization in 1990s, many molecular targets have been described to be regulated by this chimeric transcription factor. Their contribution to orchestrate Ewing sarcoma phenotype has been reported over the last decades. In this work, we will focus on the description of a selection of EWS/FLI1 targets, their functional role, and their potential clinical relevance. We will also discuss their role in other types of cancer as well as the need for further studies to be performed in order to achieve a broader understanding of their particular contribution to Ewing sarcoma development. PMID:26258070

  7. Short-term nutritional treatments grazing legumes or feeding concentrates increase prolificacy in Corriedale ewes.

    Science.gov (United States)

    Viñoles, C; Meikle, A; Martin, G B

    2009-07-01

    We tested whether short periods of increased nutrition will improve ovulation rate and prolificacy, irrespective of the method used to synchronise the cycles of the ewes. In Experiment 1, we used 138 Corriedale ewes to evaluate two factors: synchronization treatment (sponges versus a single injection of prostaglandin) and type of pasture (native versus improved with Lotus corniculatus). Ewes were mated at the end of the grazing period and prolificacy was evaluated at lambing. Grazing Lotus corniculatus for 12 days tended to increase the number of twin lambs born (P=0.09). The percentage of ewes showing oestrus during a 9-day period was similar among synchronization treatments. Animals in Experiments 2 (n=282) and 3 (n=288) were allocated to a control group or a group fed a supplement of corn grain and soybean meal for 7 days. Ewes received 2 prostaglandin injections and the supplement was fed from Days 11 to 17 after the second prostaglandin. Ovulation rate was measured in 65 (Experiment 2) and 61 (Experiment 3) ewes that were confirmed to have consumed the supplement and showed oestrus in a 4-day period. The supplement increased ovulation rate by 14% in both experiments (PLotus corniculatus and in ovulation rate to 7 days feeding with a supplement rich in energy and protein. Moreover, in these studies, prostaglandin was as effective as sponges for synchronising oestrus, an important factor in future decisions about hormonal management of fertility.

  8. Management of fetal dystocia caused by carpal flexion in ewe: A case report

    Directory of Open Access Journals (Sweden)

    Faez Firdaus Jesse Abdullah

    2015-06-01

    Full Text Available Dystocia or difficulty in parturition in a ewe may need veterinary assistance for the successful parturition. An adult ewe weighing 30 kg was presented to the Hospital of Veterinary Medicine, Universiti Putra Malaysia with the history of difficulty in giving birth. Physical examination of the ewe revealed that the animal was weak and in recumbent position. Head of a dead fetus was observed as protruding out from the vulva region. Through physical evaluation of the ewe by per vaginal examination, the condition was diagnosed as fetal dystocia. Treatment and management plans given to the ewe were episiotomy and manipulative delivery of the dead fetus via mutation and traction method. Post-operative treatment was given with Flunixin meglumine (dosed at 2.2 mg/kg bwt for 3 days, and Norodine (dosed at 1 mL/16-kg bwt once intramuscularly. The case was completely cured after 2 weeks. The risk of losing the lamb as well as the ewe increases with delay in treatment of dystocia.

  9. A preliminary study of the effects of organic farming on oocyte quality in ewe lambs.

    Science.gov (United States)

    Casao, A; María, G A; Abecia, J A

    2017-02-01

    This study tested whether feeding Rasa Aragonesa ewes certified organic feed, from 15 days before mating until lamb weaning, improved oocyte quality and in vitro maturation (IVM) and fertilization (IVF) performances of the offspring. In a second experiment, ovaries from ewe lambs that were bred on an organic farm and were of the same breed were compared with those from conventionally bred animals. The number (± standard error of the mean) of healthy oocytes per ewe lamb did not differ significantly between organic (12.2 ± 3.3) and conventionally (13.6 ± 4.0) fed ewes. Ovaries from ewe lambs born on an organic farm had significantly (P farm (25.0 ± 4.2), and higher IVM (76.5% vs. 53.1%, P organic procedures on the sheep oocyte quality indicates that the total integration in the complete organic system improved the oocyte quality of ewe lambs, although organic feeding alone was insufficient to improve quality.

  10. MASTITE E SÍNDROME DA QUEDA DO LEITE / INFECÇÃO POR Leptospira interrogans EM OVELHAS DA RAÇA SANTA INÊS NO DISTRITO FEDERAL

    Directory of Open Access Journals (Sweden)

    Adriana Helena Rosa

    2012-06-01

    Full Text Available The aim of the present work was to determine the relationship between clinical mastitis and Leptospira interrogans / Milk Drop Syndrome in Santa Inês ewes. One thousand sheep were examined on 12 farms in the Distrito Federal, Brazil, as to their clinical condition, in order to identify animals with clinical mastitis. The animals were divided into two groups: animals which presented clinical mastitis symptoms (G1 and animals which did not have clinical mastitis symptoms (G2. Blood samples were collected from all ewes of the two groups. The microscopic agglutination test was performed in order to identify the seropositive animals to Leptospira spp. Four (4.08% animals of the first group were seropositives to Leptospira spp., of which three were positives to Hardjoprajitno (Norma and Hardjoprajitno (OMS sorovars and one to both Australis and Autumnalis sorovars. In the second group, two (5.26% animals were seropositives to both Hardjoprajitno (Norma and Hardjoprajitno (OMS sorovars. A relationship between Leptospira spp. infection / milk drop syndrome and the presence of clinical mastitis in ewes (p > 0.05 was not observed.

  11. Preliminary geologic map of the Santa Barbara coastal plain area, Santa Barbara County, California

    Science.gov (United States)

    Minor, Scott A.; Kellogg, Karl S.; Stanley, Richard G.; Stone, Paul; Powell, Charles L.; Gurrola, Larry D.; Selting, Amy J.; Brandt, Theodore R.

    2002-01-01

    This report presents a new geologic digital map of the Santa Barbara coastal plain area at a compilation scale of 1:24,000 (one inch on the map = 2,000 feet on the ground) and with a horizontal positional accuracy of at least 20 m. This preliminary map depicts the distribution of bedrock units and surficial deposits and associated deformation underlying and adjacent to the coastal plain within the contiguous Santa Barbara and Goleta 7.5' quadrangles. A planned second version will extend the mapping westward into the adjoining Dos Pueblos Canyon quadrangle and eastward into the Carpinteria quadrangle. The mapping presented here results from the collaborative efforts of geologists with the U.S. Geological Survey Southern California Areal Mapping Project (SCAMP) (Minor, Kellogg, Stanley, Stone, and Powell) and the tectonic geomorphology research group at the University of California at Santa Barbara (Gurrola and Selting). C.L. Powell, II, performed all new fossil identifications and interpretations reported herein. T.R. Brandt designed and edited the GIS database,performed GIS database integration and created the digital cartography for the map layout. The Santa Barbara coastal plain is located in the western Transverse Ranges physiographic province along a west-trending segment of the southern California coastline about 100 km (62 mi) northwest of Los Angeles. The coastal plain region, which extends from the Santa Ynez Mountains on the north to the Santa Barbara Channel on the south, is underlain by numerous active and potentially active folds and partly buried thrust faults of the Santa Barbara fold and fault belt. Strong earthquakes that occurred in the region in 1925 (6.8 magnitude) and 1978 (5.1 magnitude) are evidence that such structures pose a significant earthquake hazard to the approximately 200,000 people living within the major coastal population centers of Santa Barbara and Goleta. Also, young landslide deposits along the steep lower flank of the Santa

  12. Avaliação da Adaptabilidade de Ovinos Santa Inês ao Clima Amazônico - Evaluation of the adaptability of Santa Inês sheep to amazonian climate

    Directory of Open Access Journals (Sweden)

    Costa, Érique Pedro da Silva

    2010-03-01

    Full Text Available Resumo A produção de ovinos no Brasil tem aumentado consideravelmente nosúltimos anos, principalmente devido ao avanço de técnicas de manejo,nutrição e melhoramento genético. No Norte do Brasil essa realidade não é diferente. O presente experimento teve como objetivo avaliar aadaptabilidade de ovinos da raça Santa Inês no Estado de Rondônia,verificando a viabilidade da criação desses animais. As avaliações foram realizadas em um rebanho comercial na cidade de Porto Velho, a qual está inserida nas condições do clima amazônico. Os parâmetros fisiológicos avaliados foram temperatura retal (TR e frequência respiratória (FR, durante o mês de março de 2009. Os dados ambientais foram obtidos através de termômetro de bulbo seco (TBS, bulbo úmido (TBU e termômetros de máxima (Tmax e mínima (Tmin, na sombra e ao sol. O ambiente mostrou-se como severo (ITU = 84,85 e os animais apresentaram-se com alto estresse. Apesar das condições, os cordeiros da raça Santa Inês, nascidos e criados sob as condições climáticas da região amazônica apresentaram boa adaptação à região (ITC médio de 9,7. É necessário realizar este mesmo tipo de estudo em outras épocas do ano, assim como focalizar o estudo em outras categorias animais e também raças.SummaryThe sheep production in Brazil has increased considerably in recent years, mainly due to the advancement of management techniques, nutrition and genetic improvement. In North of Brazil, this reality is no different. The present study aimed to evaluate the adaptability of sheep Santa Ines in the State of Rondônia, checking the feasibility of these animals. The evaluations were conducted in a commercial flock in the city of Porto Velho, which is inserted in the Amazon weather conditions. The physiological parameters evaluated were rectal temperature (RT and respiratory rate (RR, during the month of March 2009. The environmental data were obtained with the dry bulb

  13. Activity of alkaline and acidic phosphatase in glandular cells of uterine endometrium of puerperal ewes after exposure to polychlorinated biphenyls

    OpenAIRE

    Valocky I.; Krajničakova Maria; Legath J.; Lenhardt L.; Ostro A.; Danko J.; Tkačikova L`udmila; Mojžišova Jana; Fialkovičova Maria; Mardzinova Silvia

    2005-01-01

    The study is focused on the observation of alkaline and acidic phosphatase activity in the glandular cells of uterine endometrium in puerperal ewes after exposure to polychlorinated biphenyls. Ewes of Slovak merino breed (n=25) divided into 2 groups were included in the experiment. The animals in the experimental group (n=14) and control group (n=11) were euthanised on day 17, 25 and 34 postpartum. The ewes in the experimental group were given per os capsules of the chemical preparation Delor...

  14. Effects of calcium salts of fatty acids (Megalac) on reproductive performance and blood parameters of Kalkohi ewes

    OpenAIRE

    2012-01-01

    To determine the effects of Megalac addition on Iranian ewes' reproductive parameters, a complete randomized design was used. Multiparous Kalkohi ewes (n = 32; 3 years old) were randomly assigned to 2 groups which consumed isoenergetic and isonitrogenous control (C) or Megalac (M; 5% Megalac in diet DM) diet. All ewes were synchronized by prostaglandin injection. Blood samples were collected from d 8, 10, and 12 of estrus cycle. Diets offered 4 wk prior to mating and up to 4 wk after mating a...

  15. Study of Blood Metabolites Changes of Purebred Ghezel and Crossbred Arkhar Merinos × Ghezel Ewes during Late Pregnancy

    OpenAIRE

    2016-01-01

    Introduction As pregnancy progresses, nutrient requirements of fetus and thereby ewe increases and some changes in the levels of blood metabolites including glucose, cholesterol and total protein may occur. During gestation, maternal tissues contribute to supplying energy that required for fetus resulting in changes of ewe blood metabolites; however other factors such as breed, age, feeding type of ewes during gestation and season may influence them. The study of blood metabolic changes in di...

  16. The effect of superovulation prior to mating on fetal growth in Iambs from Javanese thin-tail ewes

    Directory of Open Access Journals (Sweden)

    W Manalu

    1999-12-01

    Full Text Available Twenty-nine fetuses (11 fetuses from 9 non-superovulated ewes and 18 fetuses from 8 superovulated ewes were used to study the effect of superovulation of ewes prior to mating on fetal weight, fetal length, the length of the body and limbs, chest circumference, weights of the body, head, neck, limb, and viscera. Superovulated ewes, though with a higher litter size, had a greater fetal growth as was indicated by the greater fetal weight and length, the length and weight of the body and limb on day 49 of pregnancy. On day 105 of pregnancy, superovulated ewes with multiple fetuses (≥3 had similar fetal growth than nonsuperovulated ewes with single and twin fetuses. However, superovulated ewes with a single fetus had greater fetal growth as was shown by the greater fetal weight and length, the length of the body and limbs, chest circumference, and weight of the body, limb, and viscera when compared to those non-superovulated ewes with a single or twin fetuses. The results of the experiment suggested that superovulation of ewes prior to mating could be used to improve fetal prenatal growth during pregnancy

  17. Assessing the usefulness of prostaglandin E2 (Cervidil) for transcervical artificial insemination in ewes.

    Science.gov (United States)

    Bartlewski, Pawel M; Candappa, Ivanka B R

    2015-12-01

    The underlying theme of this study involved the evaluation of the dilatory effects of prostaglandin E2 on the ovine cervix and thus the assessment of its potential applicability to transcervical artificial insemination (TCAI) in ewes. A novel method of prostaglandin E2 administration (controlled slow-release vaginal inserts) was examined, and the practical implications of this approach including cervical penetrability and posttreatment pregnancy rates were evaluated. The Guelph method of TCAI was performed during the seasonal anestrus (n = 40) and the breeding season (n = 40) on multiparous Rideau Arcott × Polled Dorset ewes, with or without the pretreatment with Cervidil (for a duration of 12 hours or 24 hours before TCAI). Cervical penetration rates averaged 82.5% (66 of 80), and they varied neither (P > 0.05) between the two seasons nor between Cervidil-treated ewes and their respective controls. Cervidil priming significantly reduced the total time required for TCAI during the breeding season in comparison with controls (54 vs. 98 seconds), especially after the 24-hour exposure (38 vs. 108 seconds). The time taken to traverse the uterine cervix was negatively correlated (P < 0.05) with the breed (percentage of Rideau Arcott genotype) and lifetime lamb production in seasonally anestrous ewes. Four out of 36 (11%) successfully penetrated ewes in the breeding season (three ewes allocated to the 12-hour control group and one ewe that had received Cervidil for 12 hours) became pregnant and carried the lambs to term. Vaginal mucus impedance at TCAI was significantly and positively correlated with the total time required to complete the procedure in cyclic ewes, and the negative correlation between vaginal mucus impedance and total time values at the time of controlled intravaginal drug release device removal approached to significance in anestrous ewes. The present results indicate a moderate benefit of using Cervidil for inducing cervical dilation before

  18. Crise convulsive chez les abuseurs de Tramadol et caféine: à propos de 8 cas et revue de la littérature

    Science.gov (United States)

    Maiga, Djibo Douma; Seyni, Houdou; Sidikou, Amadou; Azouma, Alfazazi

    2012-01-01

    Nous rapportons Huit cas de crises convulsives diagnostiquées comme maladie épileptique après ingestion de Tramadol et d'autres substances psychotropes dont la Caféine dans une région ou maladie épileptique et addiction au café sont fréquentes. L'objectif de ce travail était d'informer les praticiens sur le risque de convulsion lié à la consommation du Tramadol seul ou en association avec d'autres psychotropes en s'appuyant sur les données de la littérature. Il s'agissait d'une étude rétrospective et exhaustive de patients vus en consultation ambulatoire pour crise convulsive et consommation de Tramadol et de caféine de janvier à mai 2012. Les données collectées étaient les caractéristiques sociodémographiques et de la consommation de Tramadol. Le diagnostic de crise convulsive a été posé sur les renseignements obtenus à l'anamnèse. Tous les patients ont été soumis à un examen neurologique et aux critères de dépendance du Diagnostic and Statistical Manual of Mental Disorders (DSMIV)-R par rapport à leur consommation de Tramadol. Nous n'avons pas trouvé dans la littérature médicale de cas de consommation concomitante de Tramadol et de Caféine. Les données expérimentales suggèrent une action synergique du Tramadol et de la Caféine sur la douleur et le seuil épileptogène. Nos observations plaident également en faveur d'une synergie d'action de ces deux molécules dans la survenue des crises convulsives. La fréquence des crises convulsives suite à une intoxication par le Tramadol et la caféine est susceptible d'augmenter en Afrique en raison du mésusage croissant de ces substances. Une étude comparative usagers de Tramadol associé à la Caféine et usagers du Tramadol seul devrait permettre d’évaluer le risque. PMID:23308329

  19. OCORRÊNCIA DE MASTITE SUBCLÍNICA OVINA DURANTE DUAS LACTAÇÕES CONSECUTIVAS EM REBANHO DA RAÇA SANTA INÊS

    Directory of Open Access Journals (Sweden)

    Luiz Francisco Zafalon

    2015-01-01

    Full Text Available The aim of this study was to evaluate the occurrence of ovine subclinical mastitis in two lactations, and the disease evolution in two consecutive lactations. Milk samples originated from a herd with 160 Santa Inês breed sheep. In the first lactation, milk samples were collected from ewes at 14 days post-partum and during the period near weaning. In the second lactation, milk samples were collected from the same animals at 14 days postpartum, at 52 days postpartum and at weaning. Screening of subclinical mastitis was carried out preliminarily by means of California Mastitis Test (CMT. Milk samples for microbiological culture were obtained from CMT-positive and CMT-negative mammary halves. Coagulase-negative Staphylococci were the most prevalent microorganisms isolated in two lactations. Ewes that remained with subclinical mastitis in lactation 1 were predominant. Spontaneous recoveries were significantly lower in the period between 52 days of lactation and weaning of lambs. No difference was observed regarding the progression of subclinical mastitis cases compared the two lactations (P>0.05.

  20. 论英语复合词ewe lamb的合成原理%How is the compound word ewe lamb coined?

    Institute of Scientific and Technical Information of China (English)

    吴小晶

    2006-01-01

    本文从语义复合的角度分析了ewe lamb一词的合成原理,以及ewe和lamb当选构件的条件,提出了相关的语义原则(或规则).语义复制和语义渗透在ewelamb的合成中发挥了重要作用.语义复制扩大了元素的分配范围,提高了构件选择的语义标准.这就解释了为什么ewe能入选,而female、bitch、hen、girl等词则被淘汰.语义渗透原则维护了lamb的义位在其下位词ewe lamb中的状态,使得ewe 和lamb之间的矛盾彻底消解.这也解释了为什么ewe没有因为包涵[ADULT]而落选.在整个复合过程中没有发现任意性的环节,ewe lamb的逻辑性丝毫不亚于定中词组femalelamb.

  1. Águas minerais de Santa Catarina

    OpenAIRE

    Coitinho, João Batista Lins

    2000-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Esta pesquisa representa uma análise hidrogeológica das águas minerais de Santa Catarina. Em função de suas características físico-químicas, modo de ocorrência e relações com o ambiente geológico, as águas minerais do Estado foram associadas à províncias hidrogeológicas, as quais foram subdividas em domínios/aqüíferos. Destaque especial foi dado à Província Cristalina, Domínio Meridional, por apresentar um...

  2. La subjetividad internacional de la Santa Sede

    OpenAIRE

    Mosquera Monelos, Susana

    2014-01-01

    Presentamos el caso de la subjetividad internacional de la Santa Sede como un ejemplo que nos permita afrontar un nuevo enfoque del concepto de sujeto para el derecho internacional. El cumplimiento de los requisitos clásicos de la subjetividad internacional se ha visto superado por la fuerza creadora del derecho que nuevos sujetos internacionales han impulsado: ONG, sociedad civil, transnacionales, sujetos atípicos. Analizando el mecanismo de atribución de personalidad internacional de la San...

  3. Effects of Using Melatonin Implants and Syncro-Part Pessaries + PMSG on Reproduction Performance in Transylvanian Merino Breed Ewes

    Directory of Open Access Journals (Sweden)

    Ioan Padeanu

    2013-10-01

    Full Text Available Investigations were carried out in a commercial farm from Sinnicolau Mare, western Romania, on a number of 70 yearling ewes of 17-18 months of age from the native Transylvanian Merino breed. Ewes included into study lambed for the first time as maiden-ewes at the age of 14-15 months, with their lambs being weaned at the age of two months. First group (V1, numbering 25 ewes received during out of season breeding (30.05.2011 a dose of 18 mg subcutaneous melatonin implants (Melovin®, while the second group (V2 consisting out of 25 ewes were treated with subcutaneous melatonin implants + 30 mg FGA (Syncro-Part pessaries + 500 IU PMSG. Control group was represented by 20 intact females. Ewes were put to ram in July 7th 2011. Researches shown that in ewes treated with melatonin, 30 mg FGA + 500 IU PMSG (V2 the conception rate was of 80%, with a prolificacy of 140%, with a weaning rate of 1 lamb/ewe. In V1 group, the weaning rate was of 0.84 lambs/ treated ewe, with significantly lower production costs. Ewes from the control group produced a weaning rate of 0.55 lambs/ewe, significantly less (p≤0.05 comparing to V1 and V2 experimental groups. It was concluded that in Transylvanian Merino breed, although the V2 group performed best (producing 28 lambs compared to V1 group (23 lambs, the difference of 5 lambs does not cover additional production costs, therefore the use of melatonin implants alone should be recommended.

  4. Santa Ana Winds Over Los Angeles

    Science.gov (United States)

    2003-01-01

    High-resolution ocean surface wind data from NASA's Quick Scatterometer (QuikScat) illustrate the strength of Santa Ana winds that pounded Southern California this week, causing damage and spreading brush fires. The colored arrows represent various ranges of wind speed, which were still well in excess of 30 knots (34 miles per hour), even after reaching the ocean and weakening. Santa Ana winds are offshore and down-slope winds unique to Southern California that are usually channeled through mountain gaps. These Santa Ana winds extend more than 500 kilometers (310 miles) offshore before changing direction to flow along the shore.The wind speeds and directions are retrieved from range-compressed backscatter data measured by QuikScat that has much higher spatial resolution than QuikScat's standard data products. Useful applications of high-resolution science-quality wind products derived from range-compressed backscatter have been demonstrated in two scientific papers: one on Hurricane Floyd and the other on Catalina Eddies. This is the first demonstration on near-real-time retrieval applications.

  5. Les sources de protéines dans l’alimentation du bétail en France : la place des oléoprotéagineux

    OpenAIRE

    Peyronnet Corinne; Lacampagne Jean-Paul; Le Cadre Patricia; Pressenda Frédéric

    2014-01-01

    En France, les aliments concentrés totalisent 30 millions de tonnes de matières premières parmi lesquelles 64 % sont des céréales et 22 % des tourteaux d’oléagineux. Le déficit français en matières riches en protéines (dosant plus de 15 % de protéines) qui était d’environ 70 % dans les années 1980 a baissé en dessous de 40 % successivement grâce au développement du pois dans les années 1990 puis du colza depuis les années 2000 avec des surfaces totales cultivées de 2,5 millions d’hectares env...

  6. Processus ultra-rapides associés à la dynamique d'émission de la protéine GFP

    Science.gov (United States)

    Didier, P.; Guidoni, L.; Schwalbach, G.; Bigot, J.-Y.

    2002-06-01

    La protéine GFP (Green Fluorescent Protein) est un marqueur très efficace, utilisable en milieu vivant. La spectroscopie femtoseconde est particulièrement bien adaptée pour comprendre les mécanismes d'émission de cette protéine, étant donné la rapidité des processus de transfert mis en jeu. Nous-présentons des résultats sur la dynamique spectro-temporelle d'émission du mutant GFPuv résolue à l'échelle de la centaine de femtosecondes. Une transition Raman à 3300 cm^{-1} ainsi que la dynamique d'etablissement du gain avec un temps caractéristique d'environ 1.5 ps ont été mis en évidence.

  7. The Neurological Compromised Spine Due to Ewing Sarcoma. What First: Surgery or Chemotherapy? Therapy, Survival, and Neurological Outcome of 15 Cases With Primary Ewing Sarcoma of the Vertebral Column

    NARCIS (Netherlands)

    Mirzaei, L.; Kaal, S.E.J.; Schreuder, H.W.B.; Bartels, R.H.M.A.

    2015-01-01

    BACKGROUND: The vertebral column is an infrequent site of primary involvement in Ewing sarcoma. Yet when Ewing sarcoma is found in the spine, the urge for decompression is high because of the often symptomatic compression of neural structures. It is unclear in alleviating a neurological deficit whet

  8. Estrus response and fertility of Menz and crossbred ewes to single prostaglandin injection protocol.

    Science.gov (United States)

    Mekuriaw, Zeleke; Assefa, Habtemariam; Tegegne, Azage; Muluneh, Dagne

    2016-01-01

    Natural lambing in sheep in Ethiopia occurs throughout the year in a scattered manner negatively affecting survival and growth rates of the lambs born during the unfavorable season of the year. Thus, controlling the time of mating artificially using exogenous source of hormones is considered as one of the ways to mitigated problems related to haphazard lambing. To this end, an experiment was conducted to evaluate efficacy of prostaglandin-based estrus synchronization protocol in local and crossbred ewes. A total of 160 ewes (80 local and 80 crossbreds) which lambed at least once and aged 3-5 years were used. Lutalyse® (dinoprost tromethamine sterile solution equivalent to 5 mg dinoprost per ml) and its analog, Synchromate® (cloprostenol sodium equivalent to 0.250 mg cloprostenol per ml), were tested at different doses. The treatments used were intramuscular injection of (1) 2.50 ml of Lutalyse® (12.5 mg dinoprost tromethamine), (2) 2 ml of Lutalyse® (10.0 mg dinoprost tromethamine), (3) 1 ml of Synchromate® (0.25 mg of cloprostenol Sodium), and (4) 0.8 ml of Synchromate® (0.20 mg of cloprostenol Sodium). Forty ewes (20 local and 20 crossbreds) were allocated per treatment. Following injection of the respective hormones, rams of known fertility were introduced into the flock for the duration of 96 h at the ratio of one ram to 10 ewes. All estrus synchronization protocols except treatment 4 (0.8 ml of Synchromate®) induced estrus (heat) in majority (55-65%) of local and crossbred ewes within 96 h post-hormone injection. The time interval from hormone administration to onset of estrus was also more or less similar for all treatment groups except for treatment group 4 which showed heat quicker. The highest lambing rate was recorded in local ewes (84.62% (11/13) treated with 2.5 ml of Lutalyse®, whereas the least was obtained in crossbreds (33.33% (3/9) treated with 0.8 ml Synchromate®. In conclusion, even though 2.5 ml and 2 ml of Lutalyse® or 1 ml of

  9. Contribution of macrophages to plasmin activity in ewe bulk milk

    Directory of Open Access Journals (Sweden)

    M. Albenzio

    2010-04-01

    Full Text Available A total of 225 bulk sheep milk samples were collected throughout lactation to assess the contribution of macrophages to the regulation of the plasmin/plasminogen system. Samples were analyzed for composition, milk renneting parameters, and for activities of plasmin (PL, plasminogen (PG and plasminogen activators (PA. Isolation of macrophages from milk was performed using a magnetic positive separation; separated cells were lysed and activity of urokinase-PA was determined. PL activity in milk decreased during lactation (P < 0.001. The reduction in plasmin activity recorded in the mid and late lactation milk matched with the increase in PG/PL ratio (P < 0.001. The activity of PA increased throughout lactation (P < 0.001, the highest value being recorded in the late lactation milk.The amount of isolated and concentrated macrophages was higher in early and mid lactation milk than in late lactation milk (P < 0.01. Stage of lactation did not influence the activity of u-PA detected in isolated macrophages. The activity of u-PA associated with macrophages was lower than total PA activity detected in milk. Our results lend support to the hypothesis that in ewe bulk milk from healthy flocks macrophages only slightly contributed to the activation of plasmin/plasminogen system.

  10. IDH Mutation Analysis in Ewing Sarcoma Family Tumors

    Directory of Open Access Journals (Sweden)

    Ki Yong Na

    2015-05-01

    Full Text Available Background: Isocitrate dehydrogenase (IDH catalyzes the oxidative decarboxylation of isocitrate to yield α-ketoglutarate (α-KG with production of reduced nicotinamide adenine dinucleotide (NADH. Dysfunctional IDH leads to reduced production of α-KG and NADH and increased production of 2-hydroxyglutarate, an oncometabolite. This results in increased oxidative damage and stabilization of hypoxia-inducible factor α, causing cells to be prone to tumorigenesis. Methods: This study investigated IDH mutations in 61 Ewing sarcoma family tumors (ESFTs, using a pentose nucleic acid clamping method and direct sequencing. Results: We identified four cases of ESFTs harboring IDH mutations. The number of IDH1 and IDH2 mutations was equal and the subtype of IDH mutations was variable. Clinicopathologic analysis according to IDH mutation status did not reveal significant results. Conclusions: This study is the first to report IDH mutations in ESFTs. The results indicate that ESFTs can harbor IDH mutations in previously known hot-spot regions, although their incidence is rare. Further validation with a larger case-based study would establish more reliable and significant data on prevalence rate and the biological significance of IDH mutations in ESFTs.

  11. Targeting the DNA Repair Pathway in Ewing Sarcoma

    Directory of Open Access Journals (Sweden)

    Elizabeth Stewart

    2014-11-01

    Full Text Available Ewing sarcoma (EWS is a tumor of the bone and soft tissue that primarily affects adolescents and young adults. With current therapies, 70% of patients with localized disease survive, but patients with metastatic or recurrent disease have a poor outcome. We found that EWS cell lines are defective in DNA break repair and are sensitive to PARP inhibitors (PARPis. PARPi-induced cytotoxicity in EWS cells was 10- to 1,000-fold higher after administration of the DNA-damaging agents irinotecan or temozolomide. We developed an orthotopic EWS mouse model and performed pharmacokinetic and pharmacodynamic studies using three different PARPis that are in clinical development for pediatric cancer. Irinotecan administered on a low-dose, protracted schedule previously optimized for pediatric patients was an effective DNA-damaging agent when combined with PARPis; it was also better tolerated than combinations with temozolomide. Combining PARPis with irinotecan and temozolomide gave complete and durable responses in more than 80% of the mice.

  12. Electromagnetic Dissociation Cross Sections using Weisskopf-Ewing Theory

    Science.gov (United States)

    Adamczyk, Anne M.; Norbury, John W.

    2011-01-01

    It is important that accurate estimates of crew exposure to radiation are obtained for future long-term space missions. Presently, several space radiation transport codes exist to predict the radiation environment, all of which take as input particle interaction cross sections that describe the nuclear interactions between the particles and the shielding material. The space radiation transport code HZETRN uses the nuclear fragmentation model NUCFRG2 to calculate Electromagnetic Dissociation (EMD) cross sections. Currently, NUCFRG2 employs energy independent branching ratios to calculate these cross sections. Using Weisskopf-Ewing (WE) theory to calculate branching ratios, however, is more advantageous than the method currently employed in NUCFRG2. The WE theory can calculate not only neutron and proton emission, as in the energy independent branching ratio formalism used in NUCFRG2, but also deuteron, triton, helion, and alpha particle emission. These particles can contribute significantly to total exposure estimates. In this work, photonuclear cross sections are calculated using WE theory and the energy independent branching ratios used in NUCFRG2 and then compared to experimental data. It is found that the WE theory gives comparable, but mainly better agreement with data than the energy independent branching ratio. Furthermore, EMD cross sections for single neutron, proton, and alpha particle removal are calculated using WE theory and an energy independent branching ratio used in NUCFRG2 and compared to experimental data.

  13. Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Stomach

    Directory of Open Access Journals (Sweden)

    Safi Khuri

    2016-11-01

    Full Text Available Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET is a tumor of small round cells arising in skeletal tissues. These tumors rarely arise in the stomach. We present a 31-year-old healthy female patient who was admitted to our surgical ward due to upper gastrointestinal hemorrhage. Upper endoscopy revealed a large ulcerated bleeding mass originating from the lesser curvature. Biopsy revealed tumor cell immunoreactivity positive for CD99, vimentin, and Ki67 (an index of proliferation. These findings were compatible with gastric ES/PNET. The fluorescence in situ hybridization analysis result for the EWSR1 gene rearrangement (11: 22 translocation was positive. The patient refused neoadjuvant treatment and thus underwent an operation during which a mass at the lesser curvature of the stomach was found. The mass was adhering to the pancreatic tail and to the mesentery of the transverse and descending colon. Total gastrectomy, distal pancreatectomy, splenectomy, and left adrenalectomy were done. The patient refused adjuvant treatment. She is free of disease 3 years after surgery.

  14. Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Stomach

    Science.gov (United States)

    Khuri, Safi; Gilshtein, Hayim; Sayidaa, Sa'd; Bishara, Bishara; Kluger, Yoram

    2016-01-01

    Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) is a tumor of small round cells arising in skeletal tissues. These tumors rarely arise in the stomach. We present a 31-year-old healthy female patient who was admitted to our surgical ward due to upper gastrointestinal hemorrhage. Upper endoscopy revealed a large ulcerated bleeding mass originating from the lesser curvature. Biopsy revealed tumor cell immunoreactivity positive for CD99, vimentin, and Ki67 (an index of proliferation). These findings were compatible with gastric ES/PNET. The fluorescence in situ hybridization analysis result for the EWSR1 gene rearrangement (11: 22 translocation) was positive. The patient refused neoadjuvant treatment and thus underwent an operation during which a mass at the lesser curvature of the stomach was found. The mass was adhering to the pancreatic tail and to the mesentery of the transverse and descending colon. Total gastrectomy, distal pancreatectomy, splenectomy, and left adrenalectomy were done. The patient refused adjuvant treatment. She is free of disease 3 years after surgery. PMID:27920700

  15. Epidemiology and effects of gastrointestinal nematode infection on milk productions of dairy ewes

    Directory of Open Access Journals (Sweden)

    Suarez V.H.

    2009-06-01

    Full Text Available 66 Pampinta breed ewes were studied during milking to evaluate the infection and the effect of gastrointestinal nematode on milk production sheep system. Naturally infected ewes on pasture were randomly allocated to two groups: TG, suppressively treated group every four weeks with levamisole and UG, untreated group. Faecal nematode egg counts and larval differentiation were conducted monthly. Successive groups of worm free tracer lambs were grazed with ewes and then slaughtered for worm counts. Test-day milk yield of individual ewes was recorded and ewe machine-milking period length (MPL were estimated. Faecal egg counts and tracer nematode numbers increased towards midsummer and declined sharply toward the end of the study. TG (188.0 ± 60 liters produced more (p < 0.066 milk liters than UG (171.9 ± 52.2 and TG had significantly more extended (p < 0.041 MPL than those of UG. The present study showed that dairy sheep were negatively affected by worms, even when exposed to short periods of high acute nematode (mainly Haemonchus contortus infection.

  16. Exploring the surfaceome of Ewing sarcoma identifies a new and unique therapeutic target

    Science.gov (United States)

    Town, Jennifer; Pais, Helio; Harrison, Sally; Bataille, Carole; Bunjobpol, Wilawan; Zhang, Jing; Rabbitts, Terence H.

    2016-01-01

    The cell surface proteome of tumors mediates the interface between the transformed cells and the general microenvironment, including interactions with stromal cells in the tumor niche and immune cells such as T cells. In addition, the cell surface proteome of individual cancers defines biomarkers for that tumor type and potential proteins that can be the target of antibody-mediated therapy. We have used next-generation deep RNA sequencing (RNA-seq) coupled to an in-house database of genes encoding cell surface proteins (herein referred to as the surfaceome) as a tool to define a cell surface proteome of Ewing sarcoma compared with progenitor mesenchymal stem cells. This subtractive RNA-seq analysis revealed a specific surfaceome of Ewing and showed unexpectedly that the leucine-rich repeat and Ig domain protein 1 (LINGO1) is expressed in over 90% of Ewing sarcoma tumors, but not expressed in any other somatic tissue apart from the brain. We found that the LINGO1 protein acts as a gateway protein internalizing into the tumor cells when engaged by antibody and can carry antibody conjugated with drugs to kill Ewing sarcoma cells. Therefore, LINGO1 is a new, unique, and specific biomarker and drug target for the treatment of Ewing sarcoma. PMID:26979953

  17. Induction of ovulation in anestrus ewes using a dopamine receptor antagonist.

    Science.gov (United States)

    Saxena, Vijay Kumar; De, Kalyan; Kumar, Davendra; Naqvi, Syed Mohammad Khursheed; Krishnaswamy, Narayanan; Tiwari, Ashok Kumar

    2015-11-01

    Estradiol decreases the pulse frequency of LH during the nonbreeding season through dopaminergic neurons that results in anestrus in the ewe. Long-term administration of sulpiride, a dopamine antagonist, induced ovulation in seasonally anestrus mares. Accordingly, we tested whether sulpiride would induce ovulatory estrus in seasonally anestrus Malpura ewes. A total of 12 Malpura ewes were divided into sulpiride (at 0.6 mg/kg b.i.d.) or control groups. Anestrus was defined on the basis of the absence of heat signs for 2 months through twice-a-day heat detection during the nonbreeding season (October-November) and progesterone level of less than 1 ng/mL. Rates of estrus induction, ovulation, multiple ovulations, and lambing in the sulpiride-treated ewes were 83.3%, 100%, 16.6%, and 66.7%, respectively. The mean interval from treatment to estrus was 5.25 ± 1.49 days. Progesterone levels were elevated after ovulation significantly on Days 5 and 7 after estrus as compared to Day 0 after sulpiride treatment (P sulpiride treatment and estrus induction rate as well as ovulation rate (P < 0.05). It is concluded that the result provides proof of concept that the dopamine antagonist can induce ovulation in seasonally anestrus ewes.

  18. The Relationship between Selenium and T3 in Selenium Supplemented and Nonsupplemented Ewes and Their Lambs

    Directory of Open Access Journals (Sweden)

    Abd Elghany Hefnawy

    2014-01-01

    Full Text Available Twenty pregnant ewes were selected and classified into two groups. The first group received subcutaneous selenium supplementation (0.1 mg of sodium selenite/kg BW at the 8th and 5th weeks before birth and 1st week after birth while the other was control group without selenium injection. Maternal plasma and serum samples were collected weekly from the 8th week before birth until the 8th week after birth and milk samples were taken from ewes weekly, while plasma and serum samples were collected at 48 hours, 1st, 2nd, 3rd, 5th, and 8th weeks after birth from the newborn lambs. Results demonstrated significant positive relationship between maternal plasma selenium and serum T3 in supplemented and control ewes (r=0.69 to 0.72, P<0.05. There was significant (P<0.001 increase in T3 in supplemented ewes and their lambs until the 8th week after birth. There was positive relationship between milk, selenium concentration, and serum T3 in the newborn lambs of the supplemented group (r=0.84, P<0.01, while the relationship was negative in the control one (r=-0.89, P<0.01. Muscular and thyroid pathological changes were independent of selenium supplementation. Selenium supplementation was important for maintaining T3 in ewes and newborn lambs until the 8th week after birth.

  19. Ewe maternal behavior score to estimate lamb survival and performance during lactation

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    Andreia Barros de Moraes

    2016-08-01

    Full Text Available Mortality of perinatal lambs and low weight at weaning cause huge liabilities to farmers. Current study describes maternal-filial behavior and evaluates the use of maternal behavior score (MBS to estimate the behavior of ewes and lambs soon after birth, and correlate it with lamb mortality and performance during lactation. Thirty-seven Corriedale ewes were used in a completely randomized design. MBS was assessed up to 24 hours after birth, taking into consideration the distance of the ewe from the lamb at the approach of a person. Maternal behavior, placental weight, weight gain of the lambs until weaning and their survival rate were also evaluated until two hours after lambing. More than 90% of the ewes had adequate maternal behavior, with parental care, even though ewes were very sensitive to the presence of people. There was no significant correlation between MBS and maternal behavior, lamb mortality rate and live weight gain. Under these conditions, MBS was not a useful tool to estimate maternal behavior and performance of lambs.

  20. Reproductive performance of Ile de France ewes under dietary supplementation before and during the breeding season

    Directory of Open Access Journals (Sweden)

    Luis Gabriel Alves Cirne

    2016-02-01

    Full Text Available The aim of this study was to evaluate the reproductive performance of Ile de France ewes undergoing dietary supplementation before and during the breeding season, with and without association with management conditions (pre-mating shearing. Thirty-six ewes with an average body weight of 66 kg were used in the experiment. Treatments involved ewes receiving or not receiving concentrate supplementation (flushing, with groups subdivided according to the management condition to which animals were subjected: shearing or lack of it. Thus, ewes were divided into four treatments: flushed and shorn; flushed and unshorn; unflushed and shorn; and unflushed and unshorn. Flushing increased weight gain and body condition score, and when associated with shearing, it promoted anticipation of estrus. Fertility rate (86.05%, calving rate (77.77%, birth rate (113.83%, and type of birth (single: 82.29% and twin: 17.71% were not influenced. Birth weight (3.96 kg and prolificacy (1.25% also were not affected. Despite the lack of changes in reproductive traits, flushing adopted during the breeding season associated with shearing anticipated estrus in ewes.

  1. Reproductive characteristics of Awassi ewes under Cornell alternate month accelerated lambing system

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    Sabri Gül

    2010-04-01

    Full Text Available We investigated the reproductive responses of Awassi ewes under Cornell alternate month accelerated lambing (CAMAL system. Ewes were randomly allocated to two experimental groups. The first group (control group consists of 20 ewes exposed to rams in September under conventional management system while the second group (CAMAL were divided into four sub-flocks contain 20 head of ewes each one were exposed to rams to obtain three lambing in two years with different breeding and lambing months. In CAMAL ewes, oestrus was synchronized using intra-vaginal sponges with progesterone and PMSG administration. Results revealed that within CAMAL group, the percentage of animals in heat, onset of oestrus, litter size, birth weight and weaning weight were affected by mating months. September and November were the most appropriate months for oestrus ratio (97.5 % and litter size (1.18 and 0.98, respectively. Lambs of control group were heavier at birth and weaning than those of CAMAL group. On the other hand lamb yield was not affected statistically by the CAMAL administration.

  2. Gene Expression Music Algorithm-Based Characterization of the Ewing Sarcoma Stem Cell Signature

    Science.gov (United States)

    2016-01-01

    Gene Expression Music Algorithm (GEMusicA) is a method for the transformation of DNA microarray data into melodies that can be used for the characterization of differentially expressed genes. Using this method we compared gene expression profiles from endothelial cells (EC), hematopoietic stem cells, neuronal stem cells, embryonic stem cells (ESC), and mesenchymal stem cells (MSC) and defined a set of genes that can discriminate between the different stem cell types. We analyzed the behavior of public microarray data sets from Ewing sarcoma (“Ewing family tumors,” EFT) cell lines and biopsies in GEMusicA after prefiltering DNA microarray data for the probe sets from the stem cell signature. Our results demonstrate that individual Ewing sarcoma cell lines have a high similarity to ESC or EC. Ewing sarcoma cell lines with inhibited Ewing sarcoma breakpoint region 1-Friend leukemia virus integration 1 (EWSR1-FLI1) oncogene retained the similarity to ESC and EC. However, correlation coefficients between GEMusicA-processed expression data between EFT and ESC decreased whereas correlation coefficients between EFT and EC as well as between EFT and MSC increased after knockdown of EWSR1-FLI1. Our data support the concept of EFT being derived from cells with features of embryonic and endothelial cells. PMID:27446218

  3. Strategic study on energy-protein requirements for local sheep: 5. Ewes during lactation phase

    Directory of Open Access Journals (Sweden)

    I-W Mathius

    2004-03-01

    Full Text Available Thirty-six Javanese thin-tail ewes in the end of late pregnancy phase were set out to study the energy and crude protein requirements during the first eight-week of lactation phase. The ewes were penned individually in doors and randomly assigned to a 3 x 3 factorial arrangement, consisting of three levels of energy (low, medium and high and three levels of crude protein (low, medium and high diets with four ewes per treatment. The diets were pelleted and offered four times daily in approximately equal amount. Feed intake, nutrient digestibility, body weight and milk production were recorded. Results showed that, total lamb birth weights was not affected, but protein content on the ration treatments significantly altered (P0.05, while crude protein content on the ration highly significantly affected (P<0.01. Based on data recorded, the energy and protein requirements for ewes during lactation phase are highly significantly depended on ewes’ live weight, milk production and the ratio of energy metabolism and crude protein of the ration. It was concluded that in order to fulfil the crude protein and energy needs of the ewes during lactation phase, the ration given should contain crude protein and energy as much as 16% (based on dry matter and 13.4 MJ/kg dry matter respectively.

  4. Reproductive Response of Ewes Fed with Taiwan Grass Hay ( Schum. Supplemented with Duckweed ( sp. and sp.

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    P. Zetina-Córdoba

    2012-08-01

    Full Text Available The effect of duckweed (DW supplementation was evaluated on dry matter intake (DMI, presence and duration of estrus, percentage of ewes repeating estrus and pregnancy rate, as well as the concentration of progesterone (P4 in multiparous crossbred ewes from Pelibuey, Dorper, and Katahdin breeds, fed with Taiwan grass hay (TWH. Eighteen ewes with 39.7±4 kg mean body weight, kept in individual pens, were randomly assigned to one of the following treatments: T1: TWH, T2: TWH plus 200 g DW, T3: TWH plus 300 g DW. The ewes were synchronized with 40 mg fluorogestone acetate (FGA and 400 UI equine chorionic gonadotropin (eCG. Data were analyzed as a completely randomized design using the GLM procedure. DW supplementation had no effect on dry matter intake (p>0.05; however, a slight decrease of TWH intake was observed as DW supplementation increased. No differences (p>0.05 were found in the beginning of estrus, percentage of ewes presenting it, its duration, or pregnancy rate. There were no differences (p>0.05 on P4 concentration among treatments, or treatmentxperiod interaction (p>0.05. However the period was significant (p<0.01, since the P4 levels increased as time increased after the removal of the FGA device and eCG application.

  5. Intracranial Dural Metastasis of Ewing's Sarcoma: a Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Eung Yeop; Lee, Seung Koo; Kim, Dong Joon; Kim, Jin Na; Lee, Kyu Sung; Jung, Woo Hee; Kim, Dong Ik [Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2008-02-15

    Ewing's sarcoma is a malignant bone tumor that can occur anywhere in the body, but it is most commonly observed in the long bones of the arms and legs, the pelvis and in the chest. The predominant sites of metastasis include the lung (38%), bone (including the spine; 31%), and the bone marrow (11%). Metastasis of Ewing's sarcoma to the central nervous system (CNS) is relatively rare, and most of the previous reports have demonstrated involvement of the bony calvarium or brain parenchyma. We describe here the imaging findings of dural metastasis of Ewing's sarcoma, and these imaging findings have not been previously reported on in the medical literature. In conclusion, dural metastasis of Ewing's sarcoma is very rare and its imaging characteristics are similar to those of a primary tumor, which mimic the findings of a schwannoma or meningioma. Despite its rarity, secondary Ewing's sarcoma may be included in the differential diagnosis of extra-axial dural masses.

  6. Gene Expression Music Algorithm-Based Characterization of the Ewing Sarcoma Stem Cell Signature

    Directory of Open Access Journals (Sweden)

    Martin Sebastian Staege

    2016-01-01

    Full Text Available Gene Expression Music Algorithm (GEMusicA is a method for the transformation of DNA microarray data into melodies that can be used for the characterization of differentially expressed genes. Using this method we compared gene expression profiles from endothelial cells (EC, hematopoietic stem cells, neuronal stem cells, embryonic stem cells (ESC, and mesenchymal stem cells (MSC and defined a set of genes that can discriminate between the different stem cell types. We analyzed the behavior of public microarray data sets from Ewing sarcoma (“Ewing family tumors,” EFT cell lines and biopsies in GEMusicA after prefiltering DNA microarray data for the probe sets from the stem cell signature. Our results demonstrate that individual Ewing sarcoma cell lines have a high similarity to ESC or EC. Ewing sarcoma cell lines with inhibited Ewing sarcoma breakpoint region 1-Friend leukemia virus integration 1 (EWSR1-FLI1 oncogene retained the similarity to ESC and EC. However, correlation coefficients between GEMusicA-processed expression data between EFT and ESC decreased whereas correlation coefficients between EFT and EC as well as between EFT and MSC increased after knockdown of EWSR1-FLI1. Our data support the concept of EFT being derived from cells with features of embryonic and endothelial cells.

  7. Vaginal mucus from ewes treated with progestogen sponges affects quality of ram spermatozoa.

    Science.gov (United States)

    Manes, Jorgelina; Ríos, Glenda; Fiorentino, María Andrea; Ungerfeld, Rodolfo

    2016-03-15

    The use of intravaginal sponges (IS) to synchronize estrous onset in ewes provokes vaginitis, an increase in the vaginal bacterial load, and growth of bacterial species that are not present during spontaneous estrous behavior. The objective of the study was to compare the functional sperm parameters after incubating it with mucus collected from the vagina of ewes during spontaneous estrus or estrous synchronized with IS. Pooled spermatozoa were co-incubated with: (1) vaginal mucus collected from ewes in spontaneous estrus; (2) vaginal mucus collected from ewes in estrus pretreated with progestogen-impregnated IS; (3) synthetic mucus; and (4) medium without mucus as a control group. Sperm samples were evaluated after incubating it for 30 and 90 minutes. The number of colony-forming units (CFUs/mL), pH, and osmolality were greater in the mucus collected from ewes treated with IS than from those untreated (P = 0.046; P sheep in spontaneous estrus for 30 and 90 minutes (P synchronization treatments. This may partially explain the decrease in conception rate obtained with treatments with IS.

  8. I awake, she slept. Sor Juana Ines and Juan Rulfo or the new Latin American poetic condition

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    Hoover Delgado

    2015-12-01

    Full Text Available The article examines how Sor Juana Ines de la Cruz and Juan Rulfo, in dialogue with the literary tradition –especially with the work of Dante, Gongorism and the modern tradition– build a Latin American poetic condition. To that end, it studies the long oneiric ascent of Sor Juana, in First Dream; and Susana San Juan’s story, in Pedro Paramo. For the analysis, it goes to the concepts of resistance when suffering and the signals to transcendence provided by Maria Zambrano in her reflections on the essential condition of the human. It explains how Sor Juana and Susana San Juan offer such resistance: Sor Juana through the journey of knowledge, the sovereignty of the body, the exposure of the precariousness of life and the metaphor of the ascent; Susana, through the fall, madness and eroticism. Finally, it interprets in both characters, the appropriation of the signs of transcendence: the revaluation of the moment, of dreams and the creation-destruction of the divine. It concludes by showing how Sor Juana takes the momentum that starts in Europe with Montaigne, Bacon, the Renaissance and the Golden Age and proposes significant transformations that allow speaking of a different poetic condition. And how Rulfo, starting from the American mythic-religious condition, the non-place, the ontological indefiniteness, stops at the image of Purgatory: showing there the luminous consciousness, the unleashed eroticism and the sacralized madness of Susana as a relief, a possibility of leakage and human of redemption of the sentence.

  9. Coloração da gordura e qualidade da carne de ovelhas de descarte abatidas em distintos estágios fisiológicos Fat coloring and meat quality of culling ewes slaughtered at distinct physiological stages

    Directory of Open Access Journals (Sweden)

    R.S.B. Pinheiro

    2010-04-01

    Full Text Available Avaliaram-se a qualidade física do músculo Longissimus lumborum de ovelhas de descarte da raça Santa Inês, abatidas em diferentes estágios fisiológicos, a cor da gordura subcutânea desse músculo e as possíveis correlações entre as variáveis de qualidade da carne. Utilizaram-se 21 ovelhas, distribuídas nos seguintes tratamentos: T1= ovelhas que permaneceram por 60 dias em lactação com seus respectivos cordeiros e abatidas um dia após o desmame das crias; T2= ovelhas que permaneceram por 60 dias em lactação com seus respectivos cordeiros e mais um período aproximado de 30 dias sem os cordeiros e posteriormente abatidas; e T3= ovelhas que não pariram durante o ano. A cor da carne e da gordura subcutânea não foram influenciadas pelo estágios fisiológico dos animais no momento do abate, com exceção da luminosidade da carne (T1= 41,13; T2= 37,56 e T3= 38,12 L*. A qualidade física da carne apresentou pouca variação entre os tratamentos, porém a força de cisalhamento (T1= 4,08; T2=2,86 e T3=2,35 kgf/cm² e as perdas por cocção (T1=31,97; T2=35,70 e T3= 31,91 % da carne diferiram entre os tratamentos. Não se observou alta correlação entre a maioria das características avaliadas.The physical quality of the Longissimus lumborum muscle of Santa Inês culled ewes slaughtered at different physiological stages was evaluated as well as the color of the subcutaneous fat of the same muscle, and the correlations between meat quality traits. Twenty-one ewes were randomly allotted in the following treatments: T1= ewes which remained in lactation for 60 days with their respective lambs and slaughtered one day after weaning of the lambs; T2= ewes which remained in lactation for 60 days with their respective lambs, followed by an additional period of 30 days without the lambs and slaughtered afterwards; and T3= non pregnant ewes. The colors of meat and subcutaneous fat were not influenced by the physiological stage of the animals at

  10. Updates on the genus Euphorbia (Euphorbiaceae) in Santa Catarina, Brazil

    DEFF Research Database (Denmark)

    Hassemer, Gustavo; Marques Da Silva, Otávio Luis; Funez, Luís Adriano

    2017-01-01

    This contribution presents updates to the knowledge of the species of Euphorbia that occur in Santa Catarina state, southern Brazil. More specifically, we here typify the names E. cyathophora, E. hirtella, E. paranensis and E. stenophylla, and present the first records of E. cyathophora, E. grami....... graminea, E. ophthalmica and E. thymifolia for Santa Catarina. Finally, we provide an updated identification key to all 30 species of Euphorbia that occur in Santa Catarina, including native, naturalised and cultivated species....

  11. Effects of the TLR4 transgene on reproductive traits and DNA methylation pattern of oocytes in ewes

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    Yi FANG,Xiangwei FU,Junjie LI,Ming DU,Baoyu JIA,Jinlong ZHANG,Xiaosheng ZHANG,Shien ZHU

    2014-12-01

    Full Text Available This study was conducted to systematically assess the reproductive performance of transgenic TLR4 ewes. In the TLR4 transgenic founders (F0 and their positive offspring (F1, hematological and reproductive parameters and the global DNA methylation level in oocytes at various stages were analyzed. The values of the physiological and biochemical parameters determined from the blood samples did not differ significantly between the transgenic and wild-type ewes. Moreover, the transgenic ewes showed reproductive traits similar to the wild-type ewes. These traits included characteristics of puberty, the estrus cycle, estrus duration, gestation, the pregnancy rate and the superovulation response. Additionally, no significant differences were found between transgenic and wild-type ewes in the DNA methylation level of the oocytes at various stages. In summary, the preliminary evidence presented in this paper demonstrates that the presence of the TLR4 transgene did not affect the reproductive performance in sheep.

  12. Melatonin Cytotoxicity Is Associated to Warburg Effect Inhibition in Ewing Sarcoma Cells.

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    Ana M Sanchez-Sanchez

    Full Text Available Melatonin kills or inhibits the proliferation of different cancer cell types, and this is associated with an increase or a decrease in reactive oxygen species, respectively. Intracellular oxidants originate mainly from oxidative metabolism, and cancer cells frequently show alterations in this metabolic pathway, such as the Warburg effect (aerobic glycolysis. Thus, we hypothesized that melatonin could also regulate differentially oxidative metabolism in cells where it is cytotoxic (Ewing sarcoma cells and in cells where it inhibits proliferation (chondrosarcoma cells. Ewing sarcoma cells but not chondrosarcoma cells showed a metabolic profile consistent with aerobic glycolysis, i.e. increased glucose uptake, LDH activity, lactate production and HIF-1α activation. Melatonin reversed Ewing sarcoma metabolic profile and this effect was associated with its cytotoxicity. The differential regulation of metabolism by melatonin could explain why the hormone is harmless for a wide spectrum of normal and only a few tumoral cells, while it kills specific tumor cell types.

  13. Ewing's sarcoma with metachronous pulmonary metastasis after successful treatment of osteosarcoma in a child.

    Science.gov (United States)

    Stebnicky, Milan; Belak, Jozef; Bohus, Peter; Gmitter, Frantisek; Jenco, Igor; Tkacova, Ruzena

    2009-01-01

    A rare case of duplicate tumor, osteosarcoma and Ewing's sarcoma, complicated by metachronous pulmonary metastasis in a child is reported. A nine-year-old girl's osteosarcoma was treated by neoadjuvant chemotherapy followed by surgery and adjuvant chemotherapy. Four years later, resection of the chest wall to remove an Ewing's sarcoma had to be performed, followed by chemotherapy and radiotherapy. At the age of 17, the girl underwent a metastasectomy of Ewing's sarcoma metastasis to the lung. Five years later, the patient is free from any recognizable malignant disease. We conclude that after the complete surgical removal of two primary tumors, metastasectomy is an optimal treatment procedure in case of a solitary pulmonary metastasis.

  14. EFFECTS OF FEEDING AND MANAGEMENT SYSTEMS ON BODY WEIGHT AND REPRODUCTIVE PERFORMANCE OF BALOCHI EWES

    Directory of Open Access Journals (Sweden)

    M. MUNIR, A. W. JASRA1 AND M. A. MIRZA

    2007-07-01

    Full Text Available This study was conducted to assess the performance of Balochi ewes under three management systems i.e. T1-Extensive (grazing only, T2-Semi-extensive (grazing plus daily feed supplementation for nine months @ 0.625 kg/ewe/day and T3-Intensive (experimental ration only @ 1.5625 kg/ewe/day. Animals under T1 lost as high as 7.9 kg body weight during winter. T2 flock maintained their body weights and T3 achieved significantly higher body weight (i.e. 15.1 kg. Highest conception and lambing percentages (93.8% were attained under T3 group, followed by T2 (87.5% and T1 (75%. These results strongly recommend appropriate feed supplementation to small ruminants on Balochistan ranges for sustainable pastoral livelihood.

  15. Nonmetastatic Ewing's Sarcoma of the Lumbar Spine in an Adult Patient

    Science.gov (United States)

    Iacoangeli, Maurizio; Dobran, Mauro; Di Rienzo, Alessandro; di Somma, Lucia Giovanna Maria; Alvaro, Lorenzo; Moriconi, Elisa; Nocchi, Niccolò; Gladi, Maurizio; Scerrati, Massimo

    2012-01-01

    Although the spine is frequently involved in metastatic Ewing's sarcoma, primary involvement of the spine, beside sacrum, is much less frequent, especially in adult patients. Because of the low incidence of these tumors, there are currently no clinical guidelines outlining their management and a multitude of therapeutic strategies have been employed with varying success. The definitive management of Ewing's sarcoma of the spine, as in other locations, could include the combination of three main modalities: aggressive surgery, radiotherapy, and combined chemotherapy. Whenever possible, en bloc spondylectomy or extralesional resection is preferable, providing a better oncological result with a longer survival and a better preservation of the spine biomechanics. This is the lesson we learned about the case, we present here, of nonmetastatic lumbar localization by Ewing's sarcoma in as adult patient. PMID:23133768

  16. Primary Ewing's sarcoma of the greater wing of the sphenoid bone.

    Science.gov (United States)

    Sharma, R R; Netalkar, A; Lad, S D

    2000-02-01

    Primary Ewing's sarcoma is an uncommon lethal tumour of the long bones and pelvic girdle mainly affecting children and young adults. An origin in the cranial bones is extremely rare. We report a unique case of primary involvement of the greater wing of sphenoid bone in a 16-year-old patient. Aggressive management using microsurgical resection, radiotherapy and chemotherapy was curative. Localized, primary Ewing's sarcoma of the cranial bones should be considered as a distinct clinicopathological entity with an extremely low rate of dural penetration and metastases, and with a relatively better prognosis as compared with those of long bones and pelvic girdle. In neurosurgical practice, primary Ewing's sarcoma of the cranial bones requires early aggressive management to achieve adequate long-term prognosis and cure.

  17. Interferon-γ expression in trophoblast cells in pregnant ewes challenged with Chlamydophila abortus.

    Science.gov (United States)

    Worrall, S; Sammin, D J; Bassett, H F; Reid, C R; Gutierrez, J; Marques, P X; Nally, J E; O'Donovan, J; Williams, E J; Proctor, A; Markey, B K

    2011-08-01

    Pregnant ewes were challenged with Chlamydia abortus at 91-98 days of gestation and euthanised at 14, 21 and 28 days post-challenge. IFNγ mRNA labelling appeared to be co-localised with Chlamydial lipopolysaccharide within trophoblast cells in discrete areas lining the primary villi in the limbus and hilar zone of the placentomes from challenged sheep on days 21 and 28 post-infection. The presence of IFNγ was also demonstrated by immunohistochemistry. No labelling was seen in tissues from the non-infected ewes. The presence of IFNγ in trophoblast cells from infected ewes may indicate an attempt to restrict the replication of the organism and be an important trigger for the inflammatory responses that develop on the fetal side of the placenta in enzootic abortion.

  18. Effect of available space and previous contact in the social integration of Saint Croix and Suffolk ewes.

    Science.gov (United States)

    Orihuela, A; Averós, X; Solano, J; Clemente, N; Estevez, I

    2016-03-01

    Reproduction in tropical sheep is not affected by season, whereas the reproductive cycle of temperate-climate breeds such as Suffolk depends on the photoperiod. Close contact with tropical ewes during the anestrous period might induce Suffolk ewes to cycle, making the use of artificial light or hormonal treatments unnecessary. However, the integration of both breeds within the social group would be necessary to trigger this effect, and so the aim of the experiment was to determine the speed of integration of 2 groups of Saint Croix and Suffolk ewes into a single flock, according to space allowance and previous experience. For this, 6 groups of 10 ewes (half from each breed) from both breeds, housed at 2 or 4 m/ewe (3 groups/treatment) and with or without previous contact with the other breed, were monitored for 3 d. Each observation day, the behavior, movement, and use of space of ewes were collected during 10 min at 1-h intervals between 0900 and 1400 h. Generalized linear mixed models were used to test the effects of breed, space allowance, and previous experience on behavior, movement, and use of space. Net distances, interbreed farthest neighbor distance, mean interbreed distance, and walking frequencies were greater at 4 m/ewe ( movement activity ( < 0.05). Experienced ewes walked longer total distances during Day 1 and 2 ( < 0.05). Lying down frequency was greater for Day 3 than Day 1 ( < 0.05), and Suffolk ewes kept longer interindividual distances during Day 1 ( < 0.05). After 3 d of cohabitation, Suffolk and Saint Croix ewes did not fully integrate into a cohesive flock, with each breed displaying specific behavioral patterns. Decreasing space allowance and previous experience resulted in limited benefits for the successful group cohesion. Longer cohabitation periods might result in complete integration, although practical implementation might be difficult.

  19. Effect of weaning age on hair sheep lamb and ewe production traits in an accelerated lambing system in the tropics.

    Science.gov (United States)

    Godfrey, R W; Weis, A J

    2016-03-01

    This study was designed to evaluate the impact of weaning age on lamb and ewe productivity in an accelerated lambing system. St. Croix White (STX) and Dorper × St. Croix White (DRPX) lambs were assigned at birth based on breed, gender, and litter size to be weaned at 63 (Early-1; 106 lambs and 68 ewes) or 90 d of age (Late-1; 99 lambs and 60 ewes) in Exp.1 or at 63 (Early-2; 77 lambs and 57 ewes) or 120 d of age (Late-2; 75 lambs and 56 ewes) in Exp. 2. After weaning, lambs were weighed weekly and fed a concentrate ration (2% BW·lamb·d) while grazing guinea grass pastures. In Exp. 1, weaning weight was greater ( 0.06) between Early-2 and Late-2 lambs (5.1 ± 0.2 vs. 5.6 ± 0.3 kg, respectively). In Exp. 1 and 2, ewe BW at breeding and lambing and weaning and lambing rate were not different among weaning ages of lambs ( > 0.17). The Early-1 ewes exhibited estrus earlier than Late-1 ewes (10.9 ± 0.9 vs. 13.9 ± 1.0 d, respectively) but there was no difference ( > 0.63) between Early-2 and Late-2 ewes. Weaning hair lambs at 90 or 120 d of age can be done in an accelerated lambing system with no detrimental effect on lamb or ewe productivity. Late weaning resulted in a decreased number of days that lambs received high-cost, imported feed without a reduction in growth, resulting in savings of US$6 to $15 per lamb.

  20. The influence of season of lambing and lactation on reproductive activity and plasma LH concentrations in Merino ewes.

    Science.gov (United States)

    Restall, B J; Starr, B G

    1977-03-01

    Groups of Merino ewes which were lactating for 40 days (Group I) or had had their lambs removed at birth (Group II) after lambing in the winter (June) or spring (November) were fed on a high plane of nutrition. Ovarian inspections were carried out at 15 and 30 days after lambing and plasma LH levels were measured at 6-h intervals for 20-30 days. First ovulation was earlier in ewes lambing in the winter (16-6 days, range 11-26) than in the spring (24-7 days, range 15-30) but there was no difference in the number of ewes ovulating. LH levels were higher in winter-lambing ewes (2-79 +/- 3-4 ng/ml) than in those lambing in the spring (1-78 +/- 0-23 ng/ml). LH peaks were usually associated with an ovulation in spring lambing ewes but were not consistently so in the others. More ewes ovulated in Group II (72%) than in Group I (40%) but the mean time of first ovulation was similar. In the winter-lambing ewes the mean daily LH concentration was 2-40 +/- 0-32 ng/ml in Group I and 3-18 +/- 0-31 ng/ml in Group II but there were no differences between the spring-lambing ewes, (I, 1-75 +/- 0-20 ng/ml; II, 1-80 +/- 0-26 ng/ml). There were more elevations in LH levels in Group II ewes (64%) than in Group I ewes (43-8%). After lambing the LH levels increased slowly, indicating a gradual recovery of pituitary function.

  1. EFFECT OF SHEARING DURING PREGNANCY ON PRODUCTIVE PERFORMANCE IN THE POST-PARTUM PERIOD OF EWES ON EXTENSIVE HUSBANDRY

    Directory of Open Access Journals (Sweden)

    Viviane Marques Guyoti

    2015-04-01

    Full Text Available The use of shearing during pregnancy has been described as a tool for improving productivity in sheep and for minimizing perinatal mortality in lambs through the increase of fetal development. This study assessed the effect of shearing around 74 days of gestation on the productive performance of ewes and lambs during the first month of life. Forty Corriedale ewes were inseminated in autumn in Southern Brazil. All ewes were kept together at the same pasture under extensive husbandry conditions. The ewes were randomly separated into two treatment groups: twenty animals were completely sheared at 74 ± 6 days of pregnancy, and twenty were kept without sheared during pregnancy, composing the control group. Ewes and their lambs were evaluated at three different times during the experiment: at birth, between 15 and 21 days post-partum and between 22 and 45 days post-partum. Ewes had their body condition score, body weight, placental weight, milk production and serum concentrations of beta-hydroxybutyrate measured, while lambs had hematocrit, hemoglobin, and plasma lactate and glucose, as well as body weight at birth and until wean determined. Values of hematocrit and hemoglobin were lower and body weight at birth and at wean was higher in the group of lambs born from sheared ewes. Placenta weight was higher in sheared ewes. Body condition score and beta-hydroxybutyrate showed no differences between groups. Milk production of sheared ewes (1.26 L/day was higher than in control group (0.93 L/day. Shearing ewes at 74 days of pregnancy was efficient for the better development of lambs at post-birth, reducing perinatal mortality rates.

  2. Reproductive responses and productive characteristics in ewes supplemented with detoxified castor meal for a long period

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    Liliane Moreira Silva

    2014-08-01

    Full Text Available The objective of the present study was to evaluate the effects of supplementation with detoxified castor meal (DCM in the diet of ewes during pregnancy, partum, and post-partum on the weight development of their offspring and at slaughter. The study included 56 ewes with synchronized estrus that were naturally mated. At the beginning of pregnancy and in post-partum, hepatic and renal function-related parameters and progesterone levels were measured. At slaughter, the proximate composition and fatty acid profile were determined in the loin of ewes. There was no effect of diet on reproductive response after estrus synchronization. At the beginning of pregnancy, albumin and creatinine levels were lower in the DCM group. Supplementation with DCM did not alter the weight or body condition of ewes at partum. However, at weaning, the DCM group showed a higher loin-eye area (LEA in relation to the group fed diets without detoxified castor meal (WDCM. At partum, as well as at weaning, the offspring of the ewes supplemented with DCM had a larger LEA than the WDCM group. In post-partum, levels of glucose, urea, protein, and cholesterol were lower in the DCM group. The return to cyclicity was similar in both groups, with an average of 47 days after partum. At slaughter, neither anatomical and carcass components nor the results of the proximate analysis were affected by the type of diet, except for an increase in heptadecanoic acid in the DCM group. Supplementation with detoxified castor meal in the diet of ewes does not affect lambing, pregnancy, prolificacy, return to cyclicity, milk production, blood biochemical parameters, or carcass characteristics.

  3. Uterine involution and progesterone level during the postpartum period in Barbary ewes in north Libya

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    M.S. Medan

    2015-02-01

    Full Text Available The objectives of the present study were to determine the time of uterine involution and ovarian activity using ultrasound examination and progesterone assay. Weekly progesterone levels were measured starting one week postpartum until two weeks after the 1st postpartum estrus in Barbary ewes lambed during winter in AL-Bayda city, north of Libya. A total of 15 Barbary ewes were used in the present study distributed in three groups according to the month of lambing as group 1 (lambed in January, group 2 (lambed in February and group 3 (lambed in March. Ewes were examined weekly by trans-rectal ultrasound to check involution of the uterus starting one week after lambing until complete uterine involution. Blood samples were collected from the jugular vein, and serum was separated and stored at ˗20 ºC until measuring progesterone using ELISA. Results showed that uterine involution completed at day 35 postpartum in groups 1 and 2, while it occurred at day 28 in group 3. The mean progesterone level was basal (less than 1 ng/ml for a long period and started to increase at days 119, 99 and 77 postpartum in group 1, 2 and 3, respectively. One ewe did not show estrus at all during the period of study in group 2 and there were no growing follicles on their ovaries. The obtained results indicate that, uterine involution as determined by ultrasound completed earlier in ewes lambed in March than those lambed in February or January. Also, progesterone level and ultrasound examination showed that there was no ovarian activity for a longtime after parturition indicating that reproduction in Barbary ewes tends to be seasonal in AL-Bayda city, north Libya.

  4. Uterine involution and progesterone level during the postpartum period in Barbary ewes in north Libya.

    Science.gov (United States)

    Medan, M S; El-Daek, T

    2015-01-01

    The objectives of the present study were to determine the time of uterine involution and ovarian activity using ultrasound examination and progesterone assay. Weekly progesterone levels were measured starting one week postpartum until two weeks after the 1(st) postpartum estrus in Barbary ewes lambed during winter in AL-Bayda city, north of Libya. A total of 15 Barbary ewes were used in the present study distributed in three groups according to the month of lambing as group 1 (lambed in January), group 2 (lambed in February) and group 3 (lambed in March). Ewes were examined weekly by trans-rectal ultrasound to check involution of the uterus starting one week after lambing until complete uterine involution. Blood samples were collected from the jugular vein, and serum was separated and stored at -20 °C until measuring progesterone using ELISA. Results showed that uterine involution completed at day 35 postpartum in groups 1 and 2, while it occurred at day 28 in group 3. The mean progesterone level was basal (less than 1 ng/ml) for a long period and started to increase at days 119, 99 and 77 postpartum in group 1, 2 and 3, respectively. One ewe did not show estrus at all during the period of study in group 2 and there were no growing follicles on their ovaries. The obtained results indicate that, uterine involution as determined by ultrasound completed earlier in ewes lambed in March than those lambed in February or January. Also, progesterone level and ultrasound examination showed that there was no ovarian activity for a longtime after parturition indicating that reproduction in Barbary ewes tends to be seasonal in AL-Bayda city, north Libya.

  5. Salmonella Indiana as a cause of abortion in ewes: Genetic diversity and resistance patterns.

    Science.gov (United States)

    Luque, I; Echeita, A; León, J; Herrera-León, S; Tarradas, C; González-Sanz, R; Huerta, B; Astorga, R J

    2009-03-02

    Salmonella enterica subspecies enterica Indiana, a food-borne serovar uncommon in most countries, was responsible for an outbreak of abortion in a flock of Lacaune dairy ewes in southern Spain. Drinking water and feedstuff samples were analysed in an attempt to determine the source of the infection. Pigeons (Columba livia) and turtledoves (Streptopelia turtur) in close contact with the ewes were captured and examined for the bacterium. Seventeen S. Indiana strains were isolated from the ewes and wild birds and the genetic similarity among them analysed by Pulsed Field Gel Electrophoresis (PFGE) after the digestion of their genomic DNA with the restriction enzyme XbaI. The results suggest the wild birds might be responsible for the outbreak in the ewes. The strains recovered were fully susceptible to 15 out of the 16 antimicrobial agents tested: ampicillin, amoxycillin clavulanate, cephalothin, ceftriaxone, gentamicin, neomycin, streptomycin, tetracycline, ciprofloxacin, enrofloxacin, sulphonamides, trimethoprim-sulphamethoxazole, apramycin, colistin and chloramphenicol. Differences in the resistance pattern to nalidixic acid were observed; 11 strains (64.7%) were nalidixic acid resistant (R-Nx) and 6 (35.3%) sensitive (S-Nx). Among the R-Nx strains, a substitution of Gly to Cys at position 81 (Gly81àCys) of the gyrA gene in 10 strains isolated from wild birds and ovine foetuses, and of Asp to Tyr at position 87 (Asp87àTyr) in one strain isolated from ewe faeces, were revealed by sequencing the gene. To control the outbreak, enrofloxacin treatment was administered for 5 days. The same therapy was used to prevent infection during following gestation cycles, administering the antimicrobial agent at presentation and over 4 weeks before birth. Anti-bird meshes and closed drinking and feeding troughs were also installed to prevent further contact of the ewes with wild birds.

  6. [Immune response and reproductive consequences in experimentally infected ewes with Brucella ovis during late pregnancy].

    Science.gov (United States)

    Paolicchi, Fernando A; Nuñez, Marta; Fiorentino, María A; Malena, Rosana C; Trangoni, Marcos; Cravero, Silvio; Estein, Silvia M

    2013-01-01

    Ovine brucellosis by Brucella ovis is a highly prevalent disease in Argentina. This study aimed to evaluate the pathogenicity of B. ovis and the serological response in ewes during late pregnancy and in their offspring. Six adult ewes were distributed in two groupsG1 (pregnant females, n = 4) and G2 (nonpregnant females, n = 2). Three pregnant ewes at 15 days prepartum and one nonpregnant eve were inoculated with B. ovis. Sera of sheep and their offspring were analyzed by different serological tests. Samples of cervicovaginal mucus, placenta and milk were studied by bacteriology. A Brucella genus-specific PCR assay was carried out in placenta and milk samples. Placenta samples were hystopathologically processed. g1 females gave birth to live lambs, but one died hours postpartum. Serological techniques employed detected antibodies in serum of inoculated pregnant animal 5 days postchallenge. sera of female controls G1 and G2 remained negative throughout the study. Cervicovaginal mucus of infected ewes in G1 and G2 yielded negative results to bacteriology, but B. ovis was isolated from milk. The PCR assay was positive for the placenta and milk from inoculated pregnant ewes. Histopathology revealed necrotic suppurative placentitis in one placenta. However, although results demonstrated that B. ovis can invade the placenta and mammary gland, this bacterium did not cause abortion when it was inoculated intravenously at 15 days prepartum. B. ovis infection induced an early humoral response in pregnant ewes, but their lambs remained seronegative, indicating that there was no transfer of antibodies in infancy. Placenta colonization and milk excretion of B. ovis involves a potential source of infection for lambs, which could play a role as latent carriers of infection.

  7. Efficacy of anti-microbial agents on vaginal microorganisms and reproductive performance of synchronized estrus ewes

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    K.M. Mohammed

    2017-05-01

    Full Text Available Objective: To isolate and identify microflora and fungal species at different phases during estrus synchronization of ewes and estimate their prevalence; compare the effectiveness of antimicrobial administration to intravaginal sponge on the changes in the vaginal microorganisms and reproductive performance. Methods: Sixty Egyptian ewes were allocated into three equal groups (G: 1, 2 and 3. G1 was inserted with vaginal sponge containing medroxyprogesterone acetate and served as control; without antimicrobial additive. The other two groups were treated as G1, but sponges were previously injected with ciprofloxacin (G2, while sponges of G3 were injected with ciprofloxacin and clotrimazole. Vaginal swabs were collected from each treated ewe, prior sponge insertion, at sponge withdrawal and 48 h later for microbiological investigation and bacterial count. On the day of sponge removal, 300 IU/eCG was administered for each treated ewe. The identified bacterial strains before sponge insertion were tested for sensitivity with antimicrobial disks. Results: Bacterial isolates before sponge insertion were more sensitive to ciprofloxacin. Frequencies of ewes in estrus; the interval from sponge withdrawal to onset estrus and the duration of estrus were statistically similar among treated groups. The pregnancy rate in G2 (100% was higher than G1 (66.7% and G3 (82.4%. The total bacterial count before sponge insertion was similar between all treatments and increased significantly in all groups on the day of sponge withdraw. The prevailing bacteria on D0, D14 and 48 h after sponge removal for all treated groups were Staphylococcus spp. followed by Escherichia coli. Regarding to fungus species, percentages of isolation increased from 5% (before sponge insertion to 100.00% and 88.89% at sponge withdraw for G1 and G2, respectively. In G3, the fungus was declined from 10% (before sponge insertion to 5% (at sponge removal. Conclusions: The concomitant treatments by

  8. The comparison of ewe udder morphology traits of Improved Valachian, Tsigai, Lacaune breeds and their crosses

    Directory of Open Access Journals (Sweden)

    Pavol Makovický

    2014-05-01

    Full Text Available Morphological udder traits are very important for dairy animals. During this experiment, mor¬phological udder traits were subjectively assessed with the use of linear scores from selected ewes (381 ewes belonging to nine genotypes based on the basis of Improved Valachian, Tsigai and Lacaune breeds (7 udder traits; using a scale of 9 points; 1275 statements for each trait during the milking period from 2002 to 2008. Linear udder traits were: udder depth, cistern depth, teat position, teat size, udder cleft, udder attachment and udder shape. Collected data were processed with restricted methodology and maximal probability using a MIXED procedure from the SAS statistical package. During the research, all traits were influenced by the ewe genotype (P<0.001, furthermore, parity and stage of lactation had its effect as well. In most cases, crosses with 25 to 75 % share of dairy breeds, such as Lacaune and East Friesian, had larger udder cisterns than purebred Tsigai ewes and Improved Valachian breed. In¬convenient teat placement was found in the purebred Lacaune ewes, which, also, had the largest udders and cisterns among studied genotypes. Tsigai crossbreds and Improved Valachian breed, together with specialized dairy breeds had larger udders than purebred ewes (Tsigai and Improved Valachian breeds, but with negative placement of teat for milking. Compliances were statistically significant (P<0.001 due to influences on parameters for determining the size of udder (udder depth, cistern depth, teat size and udder attachment. In conclusion, udder depth, teat position and teat size may be used as suitable characteristics for marker selection, to improve milking ability of listed breeds.

  9. Chocho de Santa Catarina Ocotlan, Oaxaca (Chocho of Santa Catarina Ocotlan, Oaxaca).

    Science.gov (United States)

    Mexico Coll. (Mexico City)

    This document is one of 17 volumes on indigenous Mexican languages and is the result of a project undertaken by the Archivo de Lenguas Indigenas de Mexico. This volume contains information on Chocho, an indigenous language of Mexico spoken in Santa Catarina Ocotlan, in the state of Oaxaca. The objective of collecting such a representative sampling…

  10. Mixteco de Santa Maria Penoles, Oaxaca (Mixtec of Santa Maria Penoles, Oaxaca).

    Science.gov (United States)

    Mexico Coll. (Mexico City)

    This document is one of 17 volumes on indigenous Mexican languages and is the result of a project undertaken Archivo de Lenguas Indigenas de Mexico. This volume contains information on Mixtec, an indigenous language of Mexico spoken in Santa Maria Penoles in the state of Oaxaca. The objective of collecting such a representative sampling of the…

  11. 77 FR 36955 - Security Zone; Cruise Ships, Santa Barbara Harbor, Santa Barbara, CA

    Science.gov (United States)

    2012-06-20

    ... cruise ship located within 3 nautical miles of the Santa Barbara Harbor Breakwater Light (Light List... impact a terrorist attack against a cruise ship would have on the public interest, the Coast Guard... sea floor within a 100-yard radius of any cruise ship which is located within 3 nautical miles...

  12. Growth-promoting role of the miR-106a~363 cluster in Ewing sarcoma.

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    Layne Dylla

    Full Text Available MicroRNAs (miRs have been identified as potent regulators of both normal development and the hallmarks of cancer. Targeting of microRNAs has been shown to have preclinical promise, and select miR-based therapies are now in clinical trials. Ewing Sarcoma is a biologically aggressive pediatric cancer with little change in clinical outcomes despite improved chemotherapeutic regimens. There is a substantial need for new therapies to improve Ewing Sarcoma outcomes and to prevent chemotherapy-related secondary sequelae. Most Ewing Sarcoma tumors are driven by the EWS/Fli-1 fusion oncoprotein, acting as a gain-of-function transcription factor causing dysregulation of a variety of targets, including microRNAs. Our previous studies, and those of others, have identified upregulation of miRs belonging to the related miR-17~92a, miR-106b~25, and miR-106a~363 clusters in Ewing Sarcoma. However, the functional consequences of this have not been characterized, nor has miR blockade been explored as an anti-cancer strategy in Ewing Sarcoma. To simulate a potential therapeutic approach, we examined the effects of blockade of these clusters, and their component miRs. Using colony formation as a read-out, we find that blockade of selected individual cluster component miRs, using specific inhibitors, has little or no effect. Combinatorial inhibition using miR "sponge" methodology, on the other hand, is inhibitory to colony formation, with blockade of whole clusters generally more effective than blockade of miR families. We show that a miR-blocking sponge directed against the poorly characterized miR-106a~363 cluster is a particularly potent inhibitor of clonogenic growth in a subset of Ewing Sarcoma cell lines. We further identify upregulation of miR-15a as a downstream mechanism contributing to the miR-106a~363 sponge growth-inhibitory effect. Taken together, our studies provide support for a pro-oncogenic role of the miR-106a~363 cluster in Ewing Sarcoma, and

  13. Some dairy traits of Istrian ewes kept in semi-intensive farming conditions

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    Marina Pliško

    2016-02-01

    Full Text Available Istrian sheep has the highest milk yield among indigenous Croatian sheep breeds though originally belongs to a group of sheep of combined production traits. Since milk of Istrian sheep is traditionally processed into cheese and that processing possibilities of milk, among other things, are defined by its chemical composition and hygienic quality, the aim of this study was to determine the influence of some environmental factors (year, parity, stage of lactation, season (month of lambing on daily and lactation milk yield, lactation length, milk chemical composition and the somatic cell count (SCC in the milk of Istrian ewes. A total of 83 purebred, dairy Istrian sheep, during three consecutive lactations (from 2012 to 2014, were involved in this research. Due to conditions of feeding, care and housing, all ewes were kept in identical (semi-intensive farming conditions throughout the whole study period. During milking period of lactation regular milking controls were carried out (AT method and, on these occasions, individual milk samples for chemical composition analysis and determination of somatic cell count were taken. During average lactation length of 206 days Istrian ewes produced on average 190.77 kg of milk, or 1.1 kg of milk per day. Milk of Istrian ewes on average contained 6.81% fat, 5.90% protein, 4.32% lactose, 18.08% total solids and 11.31% non-fat solids. The geometric mean of SCC was 316*103*mL-1 of milk (log 5.50±0.02. A significant (P < 0.001 effect of the year is determined on the milk yield and the lactation length, as well as the chemical composition of milk (with the exception of protein and SCC. Ewes in the fourth lactation achieved the highest average daily (P < 0.001 and lactation milk yield (P < 0.05, while the first-lambing ewes produced milk with the highest content of total solids, milk fat and proteins. Stage of lactation significantly (P < 0.001 affected the daily milk yield, milk chemical composition, as well as

  14. Evaluation of udder cisterns and effects on milk yield of dairy ewes.

    Science.gov (United States)

    Rovai, M; Caja, G; Such, X

    2008-12-01

    Nine Manchega (0.94 L/d) and 10 Lacaune (2.07 L/d) ewes at the same stage of lactation (90 d in milk) were used to study the interbreed differences in milk yield, mammary morphological traits, and machine-milking ability. Udder traits were measured after 6 h of udder filling before the start of the experiment. Cisternal area (by ultrasonography), cisternal milk (by teat cannula drainage), and alveolar milk (by machine milking after an intravenous oxytocin injection) were randomly measured 8 h after milking for 2 wk consecutively either with an intravenous injection of an oxytocin receptor blocking agent (atosiban, AT) or without (control, C) to avoid the occurrence of milk letdown before milking. Lacaune ewes had greater udder depth (22.5 +/- 0.9 vs. 19.6 +/- 0.9 cm) and cistern height (27.1 +/- 3.8 vs. 15.6 +/- 3.5 mm), whereas Manchega ewes had longer (42.7 +/- 1.5 vs. 32.7 +/- 1.5 mm) and wider teats (17.4 +/- 0.5 vs. 13.9 +/- 0.5 mm). Values per half udder for Manchega and Lacaune ewes differed in cisternal area (12.8 +/- 0.7 and 23.7 +/- 0.6 cm(2)) and cisternal milk (120 +/- 0.6 and 269 +/- 0.5 mL), but not in alveolar milk (95 +/- 0.5 and 102 +/- 0.4 mL), respectively. Cisternal area and cisternal milk were positively correlated (r = 0.79). Ratios between cisternal and alveolar milk were 56:44 and 73:27 for Manchega and Lacaune ewes, respectively. Cisternal milk volumes obtained with the AT or C treatment were similar in Manchega (111 +/- 10 vs. 122 +/- 8 mL) but differed in Lacaune ewes (239 +/- 8 vs. 299 +/- 8 mL), respectively. Consequently, alveolar milk with AT vs. C was similar in Manchega (104 +/- 8 vs. 86 +/- 7 mL) but different in Lacaune ewes (115 +/- 7 vs. 89 +/- 7 mL). Results of this experiment confirm the need for the use of an oxytocin-blocking agent for accurate evaluation of milk contained in the udder of dairy ewes. Moreover, despite the differences in daily milk yield, alveolar milk did not vary between breeds, emphasizing the role of the

  15. Parturition induction in ewes by a progesterone receptor blocker, aglepristone, and subsequent neonatal survival: Preliminary results.

    Science.gov (United States)

    Özalp, R G; Yavuz, A; Orman, A; Seker, I; Udum Küçükşen, D; Rişvanlı, A; Demiral, Ö O; Wehrend, A

    2017-01-01

    The clinical effects of aglepristone treatment to induce parturition in ewes and their newborns were reported. Three experimental groups were defined: group AG5 (n = 5), group AG10 (n = 5), and group CG (n = 5) in which ewes were injected twice with 5, 10 mg/kg of aglepristone, and saline solution of ewes, respectively. Different parameters associated with parturition in ewes and their newborns were investigated. Serum progesterone, oxytocin, and free and conjugated total estrogens were measured after treatments until parturition. No statistical difference was found from first aglepristone administration to onset of lambing between AG5 and AG10 (23.90 ± 6.20, 40.00 ± 6.71 hours). Parturition induction in two groups shortened the gestational length significantly compared with the control group (P = 0.003). Dystocia was observed in two ewes in group AG10. The placental weight showed statistically significant difference only between the AG10 and CG (P = 0.039), but no difference was observed in the placental expulsion period between the groups. Decrease in food consumption 24 to 36 hours after parturition in all ewes and skin necrosis in an ewe in group AG5 were observed. Progesterone concentration was significantly lower in AG5 than that in ewes in group AG10 and CG (P birth weight (4.29 ± 0.28 kg), which was significantly different from the induced groups. No significant difference of blood pH and blood gases values between groups was identified both at birth and 12 hours after parturition for lambs. Significant differences could clearly be observed in total protein and blood urea nitrogen and total protein findings 12 hours after parturition (P control lambing time without any side effects in either mothers or lambs. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. Camptothecin-Based Regimens for Treatment of Ewing Sarcoma: sPast Studies and Future Directions

    Directory of Open Access Journals (Sweden)

    Lars Wagner

    2011-01-01

    Full Text Available New therapies are needed to improve survival for patients with Ewing sarcoma. Over the past decade, camptothecin agents such as topotecan and irinotecan have demonstrated activity against Ewing sarcoma, especially in combination with alkylating agents. Previous studies have shown camptothecin-based combinations to be tolerable outpatient strategies that are attractive for salvage therapy. This paper highlights important issues related to drug dosing, schedule of administration, pharmacokinetics, toxicity, and activity of commonly used camptothecin-based regimens. Also discussed are strategies for incorporating these regimens into therapy for newly diagnosed patients, including several potential possibilities for combination with targeted agents.

  17. Anti-Leptospira sp. agglutinins in ewes in the Federal District, Brazil.

    Science.gov (United States)

    Seixas, Luiza de S; de Melo, Cristiano Barros; Leite, Rômulo C; Moreira, Elvio C; McManus, Concepta M; de Castro, Márcio B

    2011-01-01

    To define the prevalence of anti-Leptospira sp. agglutinins in ewes in the Federal District, Brazil, serum samples from 157 ewes were tested for antibodies against serovars of Leptospira sp. by the microscopic agglutination test. Antibodies were detected in three flocks in a prevalence of 3% (95% CI = 0.4%-5.7%). Considering that sheep and cattle were raised together, the lack of sanitary control could represent a risk to cattle production, which is the most important activity in the Centre-West region of Brazil.

  18. Geologic Map of the Santa Barbara Coastal Plain Area, Santa Barbara County, California

    Science.gov (United States)

    Minor, Scott A.; Kellogg, Karl S.; Stanley, Richard G.; Gurrola, Larry D.; Keller, Edward A.; Brandt, Theodore R.

    2009-01-01

    This report presents a newly revised and expanded digital geologic map of the Santa Barbara coastal plain area at a compilation scale of 1:24,000 (one inch on the map to 2,000 feet on the ground)1 and with a horizontal positional accuracy of at least 20 m. The map depicts the distribution of bedrock units and surficial deposits and associated deformation underlying and adjacent to the coastal plain within the contiguous Dos Pueblos Canyon, Goleta, Santa Barbara, and Carpinteria 7.5' quadrangles. The new map supersedes an earlier preliminary geologic map of the central part of the coastal plain (Minor and others, 2002; revised 2006) that provided coastal coverage only within the Goleta and Santa Barbara quadrangles. In addition to new mapping to the west and east, geologic mapping in parts of the central map area has been significantly revised from the preliminary map compilation - especially north of downtown Santa Barbara in the Mission Ridge area - based on new structural interpretations supplemented by new biostratigraphic data. All surficial and bedrock map units, including several new units recognized in the areas of expanded mapping, are described in detail in the accompanying pamphlet. Abundant new biostratigraphic and biochronologic data based on microfossil identifications are presented in expanded unit descriptions of the marine Neogene Monterey and Sisquoc Formations. Site-specific fault kinematic observations embedded in the digital map database are more complete owing to the addition of slip-sense determinations. Finally, the pamphlet accompanying the present report includes an expanded and refined summary of stratigraphic and structural observations and interpretations that are based on the composite geologic data contained in the new map compilation. The Santa Barbara coastal plain is located in the western Transverse Ranges physiographic province along an east-west-trending segment of the southern California coastline about 100 km (62 mi) northwest

  19. PRECENCIA DE LOS NEGROS EN SANTA MARTA

    Directory of Open Access Journals (Sweden)

    Edgar Rey Sinning

    2002-08-01

    Full Text Available Partimos de señalar que las investigaciones sobre los negros en la Provincia de Santa Marta, son escasas; sin embargo, podemos afirmar que dos trabajos dan cuenta de su presencia en la ciudad y en todo su territorio. El primero, de ellos es la reciente publicación sobre la esclavitud entre los años 1791- 1851, de Dolcey Romero Jaramillo que revisa el papel de los negros en dicha provincia y ciudad. El otro es nuestro estudio sobre 10s negros llegados a Santa Marta desde el Departamento de Bolívar, en la década de los 80 del siglo pasado, titulado "Cristo Rey: Un Espacio para permanecer en el Tiempo". El presente artículo elabora una cronología de la presencia de los negros esclavos que llegaron a Santa Marta desde 1525, año de su fundación. Se señala cómo durante los primeros años se fueron autorizando dos (2 esclavos negros para algunas personas importantes, destinados a1 servicio doméstico. Política que se comienza a modificar a partir de 1535, cuando se le autorizan cien (100 esclavos al Gobernador Pedro Fernández de Lugo, y desde entonces, es importante su presencia en oficios varios, sobre todo en las actividades de las haciendas cercanas a Santa Marta, hasta el siglo XIX. A finales de ese siglo y comienzos del XX, es significativa su vinculación a] muelle -más tarde puerto-, como "muelleros" o "portuarios", asumiendo la responsabilidad de garantizar las actividades de carga y descarga del puerto samario. Igualmente se muestra su papel determinante en la construcción de las líneas férreas que unirían a la ciudad-puerto con la "Zona Bananera". Es para esta última actividad, que se traen negros desde Jamaica conocidos como "yumecas", llamados "yumecas" por los samarios.

  20. 2007款现代Santa Fe

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    现代为了开发新款Santa Fe(圣达菲)投入了1.55亿美元的资金,整个研发过程历时26个月,仅从车身长度看,新车增加了175mm。达到4675mm,同时轴距增加到2700mm。而车宽也增加了45mm,达到1890mm。

  1. INFLUENCE OF DIETARY SELENIUM SUPPLEMENTATION OF EWES ON PRODUCTION TRAITS, ANTIOXIDANT STATUS AND METABOLIC PROFILE OF LAMBS

    Directory of Open Access Journals (Sweden)

    Josip Novoselec

    2013-12-01

    Full Text Available The aim of this study was to determine the effect of dietary selenium supplementation (organic, inorganic of high pregnant ewes on the production traits of lambs, the concentration of selenium in the blood of ewes and their lambs, indicators of antioxidant status in the blood of ewes and their lambs, the metabolic profile of ewes and their lambs and concentrations of thyroid hormones. Ewes were in the last third of pregnancy, the average age of four years, healthy and in good condition, divided into three groups of 10 animals. The research lasted 4 months respectively, 2 months with ewes during high pregnancy, 2 months with ewes during lactation and on their lambs during suckling period. Ewes ration from control group one was composed from 300 g/day/animal feed mixture without addition of selenium and 150 g/day/animal barley and alfalfa hay that they had ad libitum. Feed mixture from second group of ewes was supplemented with 0.3 mg/kg organic form of selenium (Sel-Plex®, and feed mixture from third group with the same amount inorganic form of selenium (sodium selenite. Selenium supplementation of ewes feed mixture did not significantly influence on the production traits of their lambs postpartum. Selenium supplementation of ewes and their lambs had influence on a significant (P<0.01; P<0.05 increase in the concentration of selenium, GSH-Px and SOD in whole blood compared to control group of ewes. Organic selenium supplement had a more significant impact on the increase in concentration of selenium and GSH-Px in the blood. In the ewes and lambs blood was determined decrease of MDA with increasing concentrations of selenium in the blood. Generally, the selenium supplementation led to an increase (P<0.05 in the number of WBC and lymphocytes in the blood of ewes and lambs. Also, the increase in the number of RBC, HGB content and MCV in lambs and MCH as well as MCHC in ewes that had a selenium supplement in feed mixture were determined

  2. The effect of treatment with a slow-releasing oxytocin preparation at the onset of oestrus on the ovulation rate of Merino ewes : research note

    Directory of Open Access Journals (Sweden)

    P.R. King

    1997-07-01

    Full Text Available The effect of a slow-releasing oxytocin preparation on the ovulation rate of Merino ewes was investigated. Synchronised Merino ewes were subcutaneously injected with a slow-re-leasing preparation containing 10 IU oxytocin, 48 hours after sponge withdrawal. Laparo-scopic examination of the ovaries of all ewes was performed 10 d after the oxytocin treatment in order to determine the number of corpora lutea per ewe. The ovulation rate of the adult ewes of the treated and control groups was 179.1 % and 159.1 % respectively (p < 0.05 while that of the 2-tooth ewes was 108.3 % and 112.8 % respectively (p > 0.05. It would appear that a higher ovulation rate can be obtained by a single injection of a slow-releasing oxytocin preparation at the onset of oestrus. The lack of response in the 2-tooth ewes was probably due to their relatively low body weight.

  3. 33 CFR 80.1102 - Santa Catalina Island, CA.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Santa Catalina Island, CA. 80.1102 Section 80.1102 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1102 Santa Catalina Island, CA....

  4. 46 CFR 7.115 - Santa Catalina Island, CA.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Santa Catalina Island, CA. 7.115 Section 7.115 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Pacific Coast § 7.115 Santa Catalina Island, CA. (a) A line drawn from the northernmost point of Lion Head...

  5. 33 CFR 80.1138 - Santa Cruz Harbor, CA.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Santa Cruz Harbor, CA. 80.1138 Section 80.1138 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1138 Santa Cruz Harbor, CA. A line drawn...

  6. 33 CFR 80.1126 - Santa Barbara Harbor, CA.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Santa Barbara Harbor, CA. 80.1126 Section 80.1126 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1126 Santa Barbara Harbor, CA. A line...

  7. Free inside: The Music Class at Santa Ana Jail

    Science.gov (United States)

    Fierro, Joe

    2010-01-01

    This article examines the workings of the music class at the Santa Ana Jail in Santa Ana, California. It gives us insight into a jail system and a music class focused on helping inmates position themselves to become productive members of society. In this article I examine how the facility encourages inmates' good behaviour and why the music class…

  8. 27 CFR 9.31 - Santa Cruz Mountains.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Santa Cruz Mountains. 9.31... Cruz Mountains. (a) Name. The name of the viticultural area described in this section is “Santa Cruz Mountains.” (b) Approved maps. The 24 approved U.S.G.S. maps for determining the boundaries are 23...

  9. "Santa Maria" forever : Eesti ja Portugali kirjandussuhetest / Toomas Haug

    Index Scriptorium Estoniae

    Haug, Toomas, 1956-

    2012-01-01

    Jaanuaris 1961 Portugali diktaatorlikule režiimile protestiks kaaperdatud laevast "Santa Maria", mis sai omamoodi vabaduse ja vastuhaku sümboliks ka okupeeritud Eestis. Artiklis käsitletakse sellest sündmusest mõjutatud teoseid, täpsemalt Aleksander Suumanni maali "Santa Maria" ja Paul-Eerik Rummo samanimelist luuletust

  10. "Santa Maria" forever : Eesti ja Portugali kirjandussuhetest / Toomas Haug

    Index Scriptorium Estoniae

    Haug, Toomas, 1956-

    2015-01-01

    Jaanuaris 1961 Portugali diktaatorlikule režiimile protestiks kaaperdatud laevast "Santa Maria", mis sai omamoodi vabaduse ja vastuhaku sümboliks ka okupeeritud Eestis. Artiklis käsitletakse sellest sündmusest mõjutatud teoseid, täpsemalt Aleksander Suumanni maali "Santa Maria" ja Paul-Eerik Rummo samanimelist luuletust

  11. 77 FR 39726 - Land Acquisitions: Pueblo of Santa Clara

    Science.gov (United States)

    2012-07-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Land Acquisitions: Pueblo of Santa Clara AGENCY: Bureau of Indian Affairs... into trust for the Pueblo of Santa Clara on January 27, 2012. FOR FURTHER INFORMATION CONTACT:...

  12. "Santa Maria" forever : Eesti ja Portugali kirjandussuhetest / Toomas Haug

    Index Scriptorium Estoniae

    Haug, Toomas, 1956-

    2012-01-01

    Jaanuaris 1961 Portugali diktaatorlikule režiimile protestiks kaaperdatud laevast "Santa Maria", mis sai omamoodi vabaduse ja vastuhaku sümboliks ka okupeeritud Eestis. Artiklis käsitletakse sellest sündmusest mõjutatud teoseid, täpsemalt Aleksander Suumanni maali "Santa Maria" ja Paul-Eerik Rummo samanimelist luuletust

  13. "Santa Maria" forever : Eesti ja Portugali kirjandussuhetest / Toomas Haug

    Index Scriptorium Estoniae

    Haug, Toomas, 1956-

    2015-01-01

    Jaanuaris 1961 Portugali diktaatorlikule režiimile protestiks kaaperdatud laevast "Santa Maria", mis sai omamoodi vabaduse ja vastuhaku sümboliks ka okupeeritud Eestis. Artiklis käsitletakse sellest sündmusest mõjutatud teoseid, täpsemalt Aleksander Suumanni maali "Santa Maria" ja Paul-Eerik Rummo samanimelist luuletust

  14. Renal artery stenosis after radiotherapy for Ewing's sarcoma; Radiotherapieinduzierte Nierenarterienstenose nach Behandlung eines Ewing-Sarkoms

    Energy Technology Data Exchange (ETDEWEB)

    Tacconi, S.; Bieri, S. [Abt. fuer Radioonkologie, Centre Hospitalier du Centre du Valais (CHCVs), Hopital de Sion (Switzerland)

    2008-09-15

    Background: the fact that therapeutic irradiation can induce significant stenosis in the arteries of the head, neck, and chest, as welt as in the aorta and the iliac arteries, is familiar in daily practice and well documented in the literature. By contrast, radiation-induced renal artery stenosis seems to be a less widely known complication. Patients and methods: the sudden onset of medically refractory arterial hypertension and coma in a 27-year-old man is reported, who had been treated at age 20 with chemotherapy and radiotherapy for Ewing's sarcoma in the lumbar region. This treatment had been performed at the hospital of Sion, Switzerland in 2001. Also, the relevant literature from 1965 to 2007 is reviewed to underscore various aspects of this problem and to demonstrate the clinical relevance of renal artery stenosis as a potential long-term sequela of radiotherapy. Conclusion: radiation-induced renal artery stenosis has only rarely been described in the literature, but arterial hypertension due to radiation-induced renal artery stenosis is a serious long-term sequela that can appear at a latency of up to 20 years after treatment. The paucity of reports presumably reflects the lesser frequency of radiotherapy for retroperitoneal tumors as compared to head-and-neck cancers, as well as lower awareness of the problem due to diagnostic bias in the era before CT and MRI were in routine use: at that time, carotid artery stenosis was easy to diagnose by ultrasonography, while radiation-induced renal artery stenosis, whose real incidence may well be higher, probably often went undetected. Thus, when a patient with a history of abdominal or retroperitoneal radiotherapy unexpectedly develops intractable hypertension, radiation-induced renal artery stenosis must be included in the differential diagnosis. (orig.)

  15. Heavy rainfall equations for Santa Catarina, Brazil

    Directory of Open Access Journals (Sweden)

    Álvaro José Back

    2011-12-01

    Full Text Available Knowledge of intensity-duration-frequency (IDF relationships of rainfall events is extremely important to determine the dimensions of surface drainage structures and soil erosion control. The purpose of this study was to obtain IDF equations of 13 rain gauge stations in the state of Santa Catarina in Brazil: Chapecó, Urussanga, Campos Novos, Florianópolis, Lages, Caçador, Itajaí, Itá, Ponte Serrada, Porto União, Videira, Laguna and São Joaquim. The daily rainfall data charts of each station were digitized and then the annual maximum rainfall series were determined for durations ranging from 5 to 1440 min. Based on these, with the Gumbel-Chow distribution, the maximum rainfall was estimated for durations ranging from 5 min to 24 h, considering return periods of 2, 5, 10, 20, 25, 50, and 100 years,. Data agreement with the Gumbel-Chow model was verified by the Kolmogorov-Smirnov test, at 5 % significance level. For each rain gauge station, two IDF equations of rainfall events were adjusted, one for durations from 5 to 120 min and the other from 120 to 1440 min. The results show a high variability in maximum intensity of rainfall events among the studied stations. Highest values of coefficients of variation in the annual maximum series of rainfall were observed for durations of over 600 min at the stations of the coastal region of Santa Catarina.

  16. Milk production and physiological traits of ewes and goats housed indoor or grazing at different daily timing in summer

    Directory of Open Access Journals (Sweden)

    Massimo Todaro

    2010-01-01

    Full Text Available During a 6 week trial in summer, 3 homogeneous groups, each consisting of 5 Comisana ewes and 5 Rossa Mediterranea goats, grazed watered forage resources during day (D or night (N, or were housed indoor and supplied with mowed herbage(H. Maximum THI peaked at 94 at the end of July, and was almost constantly higher of 80. Milk yield was higher in N than in D and H goats, whereas N ewes produced more milk than H group, but their milk yield was higher than D ewes only in the period with the highest THI values. The lower urea in N goat milk, and the higher casein in N ewe milk, seem to indicate a better efficiency in dietary nitrogen utilization of night grazing animals. N ewes showed lower SCC in milk, and higher incidence of clotting milk samples, in comparison to other ewes. N goats and ewes showed lower rectal temperature and pulse rate in the afternoon and, among metabolic parameters, higher hematic level of sodium. Night grazing was confirmed to be a management practice for increasing heat tolerance, to which goats appeared to be more sensitive in terms of milk yield.

  17. Effect of omission of machine stripping on milk production and parlor throughput in East Friesian dairy ewes.

    Science.gov (United States)

    McKusick, B C; Thomas, D L; Berger, Y M

    2003-02-01

    Due to the large cisternal storage capacity and non-vertical teat placement in most dairy ewes, machine stripping is commonly performed to remove milk not obtained by the machine. However, stripping requires individual manual intervention, lengthens the milking routine, and could inadvertently lead to overmilking of other ewes in the parlor. The objective of the present experiment was to estimate the effect of omission of machine stripping on milk production and parlor throughput. East Friesian crossbred dairy ewes that had been machine milked and stripped twice daily from d 0 to 79 postpartum, were randomly assigned to two stripping treatments for the remainder of lactation: normal stripping (S, n = 24), or no stripping (NS, n = 24). The NS ewes yielded 14% less commercial milk during the experiment, but had similar lactation length, milk composition, and somatic cell count compared to S ewes. Average machine milk yield (amount of milk obtained without manual intervention) tended to be greater for NS compared to S ewes. Average machine-on time for S ewes was longer than for NS ewes because of stripping, which may have resulted in over-milking of many ewes in the S group. Results from a milking simulation indicated that parlor throughput would increase by 33%, and overmilking would not occur when stripping was omitted from the milking routine. These results collectively suggest that residual milk left in the udder as a result of omission of machine stripping does not negatively influence milk quality and the loss in commercial milk yield could be compensated for by improved parlor throughput.

  18. Motivation to obtain a food reward of pregnant ewes in negative energy balance: behavioural, metabolic and endocrine considerations.

    Science.gov (United States)

    Verbeek, E; Waas, J R; Oliver, M H; McLeay, L M; Ferguson, D M; Matthews, L R

    2012-07-01

    Low food availability often coincides with pregnancy in grazing animals. This study investigated how chronic reductions in food intake affected feeding motivation, and metabolic and endocrine parameters in pregnant sheep, which might be indicative of compromised welfare. Ewes with an initial Body Condition Score of 2.7±0.3 (BCS; 0 indicates emaciation and 5 obesity) were fed to attain low (LBC 2.0±0.0,), medium (MBC 2.9±0.1) or high BCS (HBC 3.7±0.1) in the first trimester of pregnancy. A feeding motivation test in which sheep were required to walk a set distance for a palatable food reward was conducted in the second trimester. LBC and MBC ewes consumed more rewards (P=0.001) and displayed a higher expenditure (P=0.02) than HBC ewes, LBC ewes also tended to consume more rewards than MBC ewes (P=0.09). Plasma leptin and glucose concentrations were inversely correlated to expenditure (both Pnegative energy balance, with lower muscle dimensions, plasma glucose, leptin, insulin, cortisol, and insulin-like growth factor-1 concentrations and higher free fatty acids concentrations compared to HBC ewes; metabolic and endocrine parameters of the MBC ewes were intermediate. The high feeding motivation and negative energy balance of low BCS ewes suggested an increased risk of compromised welfare. Imposing even a small cost on a food reward reduced motivation substantially in high BCS ewes (despite high intake when food was freely available). Assessment of a willingness to work for rewards, combined with measures of key metabolic and endocrine parameters, may provide sensitive barometers of welfare in energetically-taxed animals.

  19. Effect of Bacillus licheniformis and Bacillus subtilis supplementation of ewe's feed on sheep milk production and young lamb mortality.

    Science.gov (United States)

    Kritas, S K; Govaris, A; Christodoulopoulos, G; Burriel, A R

    2006-05-01

    The purpose of this pilot study was to evaluate under field conditions the effect of a probiotic containing Bacillus licheniformis and Bacillus subtilis on young lamb mortality and sheep milk production when administered in the late pregnancy and lactation feed of ewes. In a sheep farm, two groups of milking ewes with identical genetic material, management, nutrition, health status and similar production characteristics were formed. One group (46 ewes) served as control, while the other one (48 ewes) served as a probiotic-treated group. Both groups of ewes received a similar feeding regiment, but the ewes of the second group were additionally offered a probiotic product containing B. licheniformis and B. subtilis (BioPlus 2B, Chr. Hansen, Denmark) at the approximate dose of 2.56 x 10(9) viable spores per ewe per day. Lamb mortality during the 1.5 months suckling period, and milk yield during the 2 months of milk collection for commercial purposes have been recorded. In the non-treated control group, 13.1% mortality was observed versus 7.8% in the probiotic-treated group (P = 0.33), with mortality being mainly due to diarrhoea. Microbiological examination of diarrhoeic faeces from some of the dead lambs in both groups revealed the presence of Escherichia coli. The average daily milk yield per ewe was significantly lower in the control group (0.80 l) than that in the probiotic-treated group (0.93 l) (P milk in ewes that received probiotics was significantly (P milk yields, fat and protein content.

  20. Ewings sarcoma of 4th metacarpal bone of right hand, a rare case report

    Directory of Open Access Journals (Sweden)

    Basharat Mubeen

    2014-05-01

    Full Text Available Ewings sarcoma of the hand is relatively rare. Ewings sarcoma can present with minimal pain and swelling of the affected digit. The Erythrocyte sedimentation rate and C-reactive protein may be high. Because of these features, this can be confused with an inflammatory lesion. This leads to starting of inappropriate treatment and delay in diagnosis. Radiologically, Ewings sarcoma can present with a plethora of features from permeative bone destruction to expansile lesions with or without periosteal reaction. We present a case of 10 year old male, with complaints of pain and swelling in right hand, which on X-ray showed periosteal reaction, giving a sun burst appearance. So the provisional diagnosis of osteosarcoma was made. The diagnosis of ewings sarcoma was made on FNAC [fine needle aspiration cytology] which was later on confirmed on histopathology. We intend to report this case, because it is very rare location and the radiological features can mimic other lesions which commonly occur in this location like chronic osteomyelitis, osteosarcoma so it can be easily missed especially at preliminary evaluations.

  1. Effects of non-structural carbohydrate levels of diet on milk yield of primiparous Sarda ewes

    Directory of Open Access Journals (Sweden)

    T. Di Lella

    2011-03-01

    Full Text Available In recent decades Sarda sheep have spread almost throughout Italy due to their high milk yield aptitude. Genetic improvement has contributed greatly to increase production that in 1999 was 137 litres in 110 days of milking in primiparous ewes (Sanna et al., 2000. Knowledge of dairy sheep rationing has also improved apace, with benefits for performance of bred animals...

  2. Partitioning of late gestation energy expenditure in ewes using indirect calorimetry and a linear regression approach

    DEFF Research Database (Denmark)

    Kiani, Alishir; Chwalibog, André; Nielsen, Mette O

    2007-01-01

    study metabolizable energy (ME) intake ranges for twin-bearing ewes were 220-440, 350- 700, 350-900 kJ per metabolic body weight (W0.75) at week seven, five, two pre-partum respectively. Indirect calorimetry and a linear regression approach were used to quantify EE(gest) and then partition to EE...

  3. Trematode infections in pregnant ewes can predispose to mastitis during the subsequent lactation period.

    Science.gov (United States)

    Mavrogianni, V S; Papadopoulos, E; Spanos, S A; Mitsoura, A; Ptochos, S; Gougoulis, D A; Barbagianni, M S; Kyriazakis, I; Fthenakis, G C

    2014-02-01

    Objective was to investigate if trematode infections predispose ewes to mastitis and/or metritis. We used 80 trematode-infected ewes: primigravidae in group P-A and multigravidae in M-A remained untreated, primigravidae in P-B and multigravidae in M-B were drenched with netobimin and multigravidae in M-C were given rafoxanide. We collected faecal samples for parasitological examination, blood samples for β-hydroxybutyrate concentration measurement and uterine content, teat duct material and milk samples for bacteriological examination. We found significant differences in blood β-hydroxybutyrate concentrations between M-A, M-B and M-C during pregnancy (P ⩽ 0.002). We did not observe significant differences between groups regarding development of metritis (P>0.83). We found that for M-A, M-B and M-C ewes, respectively, median time to first case of mastitis was 5.75, 21 and 6.75 days after lambing (P = 0.003) and incidence risk of mastitis was 0.308, 0.069 and 0.222 (P = 0.047). We postulate that trematode infections predispose ewes to mastitis; perhaps, increased β-hydroxybutyrate blood concentrations adversely affect mammary cellular defences. This is the first report associating parasitic infections with mastitis in sheep. Copyright © 2013 Elsevier Ltd. All rights reserved.

  4. Cadmium chronic administration to lactating ewes. Reproductive performance, cadmium tissue accumulation and placental transfer

    Energy Technology Data Exchange (ETDEWEB)

    Floris, B.; Bomboi, G.; Sechi, P.; Marongiu, M. L. [Sassari Univ., Sassari (Italy). Dipt. di Biologia Animale; Pirino, S. [Sassari Univ., Sassari (Italy). Ist. di Patologia Generale, Anatomia Patologica e Clinica Ostetrico-chirurgica Veterinaria

    2000-12-01

    20 lactating ewes were allotted to two groups: 10 subjects received orally 100 mg/day of CdCl{sub 2} for 108 consecutive days, and the remaining 10 acted as control. Reproductive performance in ewes and cadmium tissue accumulation, both in ewes and their lambs, were investigated. The results showed that in ewes: 1) the regular cadmium intestinal intake negatively influences all reproductive parameters; 2) cadmium is particularly accumulated in kidney and liver, bur also in mammary gland, although at distinctly lower level; 3) chronic administration does not increase cadmium placental transfer in lactating pregnant subjects. [Italian] 20 pecore in lattazione sono state suddivise in 2 gruppi: 10 soggetti ricevettero per os 100 mg/giorno di CdCl{sub 2} per 108 giorni consecutivi, e i restanti 10 funsero da controllo. Sono stati studiati i parametri riproduttivi delle pecore e l'accumulo di cadmio nei tessuti, sia delle pecore che dei loro agnelli. I risultati hanno mostrato che negli ovini: 1) il regolare assorbimento intestinale di cadmio influenza negativamente tutti i parametri riproduttivi; 2) il cadmio viene accumulato principalmente nei reni e nel fegato, ma anche dalla ghiandola mammaria, sebbene in misura nettamente inferiore; 3) la somministrazione cronica di cadmio nei soggetti gravidi non incrementa il suo passaggio transplacentare.

  5. Individual mineral supplement intake by ewes swath grazing or confinement fed pea-barley forage

    Science.gov (United States)

    Previous research has reported high variation in intake of self-fed protein and/or energy supplements by individual animals, however little is known about variation in consumption of mineral supplements. Sixty mature range ewes (non-pregnant, non-lactating) were used in a completely randomized desig...

  6. N-carbamylglutamate and L-arginine improved maternal and placental development in underfed ewes.

    Science.gov (United States)

    Zhang, Hao; Sun, Lingwei; Wang, Ziyu; Deng, Mingtian; Nie, Haitao; Zhang, Guomin; Ma, Tiewei; Wang, Feng

    2016-06-01

    The objectives of this study were to determine how dietary supplementation of N-carbamylglutamate (NCG) and rumen-protected L-arginine (RP-Arg) in nutrient-restricted pregnant Hu sheep would affect (1) maternal endocrine status; (2) maternal, fetal, and placental antioxidation capability; and (3) placental development. From day 35 to day 110 of gestation, 32 Hu ewes carrying twin fetuses were allocated randomly into four groups: 100% of NRC-recommended nutrient requirements, 50% of NRC recommendations, 50% of NRC recommendations supplemented with 20g/day RP-Arg, and 50% of NRC recommendations supplemented with 5g/day NCG product. The results showed that in maternal and fetal plasma and placentomes, the activities of total antioxidant capacity and superoxide dismutase were increased (P0.05) in both NCG- and RP-Arg-treated underfed ewes. A supplement of RP-Arg and NCG reduced (P<0.05) the concentrations of progesterone, cortisol, and estradiol-17β; had no effect on T4/T3; and improved (P<0.05) the concentrations of leptin, insulin-like growth factor 1, tri-iodothyronine (T3), and thyroxine (T4) in serum from underfed ewes. These results indicate that dietary supplementation of NCG and RP-Arg in underfed ewes could influence maternal endocrine status, improve the maternal-fetal-placental antioxidation capability, and promote fetal and placental development during early-to-late gestation.

  7. The estrous cycle of the ewe is resistant to disruption by repeated, acute psychosocial stress.

    Science.gov (United States)

    Wagenmaker, Elizabeth R; Breen, Kellie M; Oakley, Amy E; Tilbrook, Alan J; Karsch, Fred J

    2010-06-01

    Five experiments were conducted to test the hypothesis that psychosocial stress interferes with the estrous cycle of sheep. In experiment 1, ewes were repeatedly isolated during the follicular phase. Timing, amplitude, and duration of the preovulatory luteinizing hormone (LH) surge were not affected. In experiment 2, follicular-phase ewes were subjected twice to a "layered stress" paradigm consisting of sequential, hourly application of isolation, restraint, blindfold, and predator cues. This reduced the LH pulse amplitude but did not affect the LH surge. In experiment 3, different acute stressors were given sequentially within the follicular phase: food denial plus unfamiliar noises and forced exercise, layered stress, exercise around midnight, and transportation. This, too, did not affect the LH surge. In experiment 4, variable acute psychosocial stress was given every 1-2 days for two entire estrous cycles; this did not disrupt any parameter of the cycle monitored. Lastly, experiment 5 examined whether the psychosocial stress paradigms of experiment 4 would disrupt the cycle and estrous behavior if sheep were metabolically stressed by chronic food restriction. Thirty percent of the food-restricted ewes exhibited deterioration of estrous cycle parameters followed by cessation of cycles and failure to express estrous behavior. However, disruption was not more evident in ewes that also encountered psychosocial stress. Collectively, these findings indicate the estrous cycle of sheep is remarkably resistant to disruption by acute bouts of psychosocial stress applied intermittently during either a single follicular phase or repeatedly over two estrous cycles.

  8. Impedometric properties of the vulvar and vaginal tissues of ewes during the oestrous cycle.

    Science.gov (United States)

    Adam, L; Aizinbud, E; Tadmor, A; Schindler, H

    1981-01-01

    Tissue electrical conductance (G) and capacitance (C) were measured in vulvar and vaginal tissues of ewes by a spectroimpedographic method at frequencies from 10 Hz to 100 kHz. The calculated specific conductance (mumho/cm) at 100 kHz was 3082 +/- 20 (s.e.m.) in oestrus and 2153 +/- 16 in dioestrus (n = 8) (P standing heat.

  9. Selection for superior growth advances the onset of puberty and increases reproductive performance in ewe lambs.

    Science.gov (United States)

    Rosales Nieto, C A; Ferguson, M B; Macleay, C A; Briegel, J R; Martin, G B; Thompson, A N

    2013-06-01

    The reproductive efficiency of the entire sheep flock could be improved if ewe lambs go through puberty early and produce their first lamb at 1 year of age. The onset of puberty is linked to the attainment of critical body mass, and therefore we tested whether it would be influenced by genetic selection for growth rate or for rate of accumulation of muscle or fat. We studied 136 Merino ewe lambs with phenotypic values for depth of eye muscle (EMD) and fat (FAT) and Australian Sheep Breeding Values at post-weaning age (200 days) for live weight (PWT), eye muscle depth (PEMD) and fat depth (PFAT). First oestrus was detected with testosterone-treated wethers and then entire rams as the ewes progressed from 6 to 10 months of age. Blood concentrations of leptin and IGF-I were measured to test whether they were related to production traits and reproductive performance (puberty, fertility and reproductive rate). In total, 97% of the lambs reached first oestrus at average weight 39.4 ± 0.4 kg (mean ± s.e.m.) and age 219 days (range 163 to 301). Age at first oestrus decreased with increases in values for PWT (P growth can accelerate the onset of puberty and increase fertility and reproductive rate of Merino ewe lambs. The metabolic hormones, IGF-I and leptin, might act as a physiological link between the growing tissues and the reproductive axis.

  10. Pregnancy rates after ewes were treated with estradiol-17beta and oxytocin.

    Science.gov (United States)

    Cervical dilation may improve transcervical sheep embryo-transfer procedures, if the cervical dilation method does not reduce pregnancy rates. This experiment was conducted to determine whether estradiol-17beta-oxytocin treatment, which dilates the cervix in luteal-phase ewes, affects pregnancy rat...

  11. The ability of ewes with lambs to learn a virtual fencing system.

    Science.gov (United States)

    Brunberg, E I; Bergslid, I K; Bøe, K E; Sørheim, K M

    2017-05-11

    The Nofence technology is a GPS-based virtual fencing system designed to keep sheep within predefined borders, without using physical fences. Sheep wearing a Nofence collar receive a sound signal when crossing the virtual border and a weak electric shock if continuing to walk out from the virtual enclosure. Two experiments testing the functionality of the Nofence system and a new learning protocol is described. In Experiment 1, nine ewes with their lambs were divided into groups of three and placed in an experimental enclosure with one Nofence border. During 2 days, there was a physical fence outside the border, during Day 3 the physical fence was removed and on Day 4, the border was moved to the other end of the enclosure. The sheep received between 6 and 20 shocks with an average of 10.9±2.0 (mean±SE) per ewe during all 4 days. The number of shocks decreased from 4.38±0.63 on Day 3 (when the physical fence was removed) to 1.5±0.71 on Day 4 (when the border was moved). The ewes spent on average 3%, 6%, 46% and 9% of their time outside the border on Days 1, 2, 3 and 4, respectively. In Experiment 2, 32 ewes, with and without lambs, were divided into groups of eight and placed in an experimental enclosure. On Day 1, the enclosure was fenced with three physical fences and one virtual border, which was then increased to two virtual borders on Day 2. To continue to Day 3, when there was supposed to be three virtual borders on the enclosure, at least 50% of the ewes in a group should have received a maximum of four shocks on Day 2. None of the groups reached this learning criterion and the experiment ended after Day 2. The sheep received 4.1±0.32 shocks on Day 1 and 4.7±0.28 shocks on Day 2. In total, 71% of the ewes received the maximum number of five shocks on Day 1 and 77% on Day 2. The individual ewes spent between 0% and 69.5% of Day 1 in the exclusion zone and between 0% and 64% on Day 2. In conclusion, it is too challenging to ensure an efficient learning

  12. Thermogenesis, blood metabolites and hormones, and growth of lambs born to ewes supplemented with algae-derived docosahexaenoic acid.

    Science.gov (United States)

    Keithly, J I; Kott, R W; Berardinelli, J G; Moreaux, S; Hatfield, P G

    2011-12-01

    Neonatal lamb mortality is a major factor affecting profitability in the sheep industry, and lamb thermogenesis is a key element in neonatal lamb survival. Increased lamb vigor has been reported when ewes were supplemented during late gestation with algae-derived docosahexaenoic acid (DHA); however, the effects of DHA on lamb thermogenesis and immunocompetence have not been investigated. Eighty twin-bearing Targhee ewes (ages 2 to 5 yr; 68.5 ± 3 kg) were assigned randomly to 1 of 2 supplement treatments to determine the effects of feeding DHA to ewes during late gestation and early lactation on lamb thermogenesis, serum metabolites and hormones, and lamb growth. Supplement treatments were 12 g·ewe(-1)·d(-1) of algae-derived DHA (DHA Gold Advanced Bionutrition Corp., Columbia, MD; algae-derived DHA); and no algae-derived DHA (control). Supplements were individually fed daily during the last 30 d (±7 d) of gestation and pen fed (6 pens/treatment with 6 or 7 ewes/pen) during the first 38 d (±7 d) of lactation. One hour after lambing and before nursing, twin-born lambs were weighed, blood sampled via jugular puncture, and placed in a dry cold chamber for 30 min (0°C), and rectal temperatures were recorded every minute for 30 min. Lambs were removed from the cold chamber, blood sampled, warmed for 15 min, and returned to their dam. Ewes were blood sampled, and colostrum samples were collected 1 h postpartum. Ewe and lamb sera were assayed for glucose, NEFA, cortisol, and leptin. Lamb rectal temperature, glucose, NEFA, cortisol, leptin, and birth weights did not differ between treatments. The BW at 38 d was greater (P = 0.03) for lambs born to control ewes than for lambs born to algae-derived DHA-supplemented ewes; however, the colostrum of algae-derived DHA-supplemented ewes had a greater specific gravity (P = 0.05) than for control ewes. Overall, despite a potentially positive effect on ewe colostral IgG concentrations, supplementation of algae-derived DHA during

  13. Very Late Local Relapse of Ewing's Sarcoma of the Head and Neck treated with Aggressive Multimodal Therapy

    Directory of Open Access Journals (Sweden)

    J. Thariat

    2008-01-01

    Full Text Available Ewing's sarcoma's relapse rarely occurs more than two years after the initial diagnosis. We report the case of a 26-year-old man with a history of Ewing's sarcoma of the left maxillary sinus at the age of 10 who presented with a very late local relapse, 16 years after the first occurrence of disease. Ultimate control was achieved after multimodal therapy including surgery, high-dose chemotherapy, and radiotherapy. This report indicates that local relapses of Ewing's sarcoma can be treated with curative intent in selected cases.

  14. Pristup uzurpacijama zemljišta na teritoriji općine Maglaj : Approach of land usurpation of municipality of Maglaj theritory

    Directory of Open Access Journals (Sweden)

    Faris Habibović

    2012-12-01

    Full Text Available Rad na temu „Pristup uzurpacijama zemljišta na teritoriji općine Maglaj“obrađuje postupak raspravljanja uzurpacija na teritoriji općine Maglaj uz korištenje odgovarajućih softverskih aplikacija. U okviru rada je opisan postupak povlačenja granične linije između šuma i šumskog zemljišta sa jedne strane i poljoprivrednog zemljišta sa druge strane, a potom su date karakteristike uzurpiranog zemljišta-parcela. Granična linija je na planovima povučena u AutoCAD programskom paketu, a baza podataka kao i pregledna skica za sve šumske komplekse izrađena koristeći softversku aplikaciju ArcGIS. U radu su obrađene tri katastarske općine (k.o. Ošve, k.o. Moševac i k.o. Ravna. : This paper deals with the process of discussing land usurpation in the territory of Maglaj municipality using appropriate software applications. Drawing procedure of the boundary line between the forest (forest land and farmland is described. Later are given characteristics of usurped land - lots. Boundary line is drawn on the plans in AutoCAD software, and the database and review drafts of all forest complexes have been made using ArcGIS software application. In this paper three cadastral municipalities are processed (cadastral municipality Ošve, cadastral municipality Moševac and cadastral municipality Ravna.

  15. EFFECT OF FEEDING SEASON ON REPRODUCTIVE AND PRODUCTIVE TRAITS OF EWES AND SUCKLING LAMBS

    Directory of Open Access Journals (Sweden)

    Zvonko Antunović

    2003-12-01

    Full Text Available This paper aims to investigate feeding season effect (winter and summer on reproductive and productive traits of the ewes and suckling lambs. Biological investigations were conducted on 60 Merinolandschaf breed ewes aged 4 years on the average and their lambs (123 in the suckling-ablactation period. In the winter feeding season ewes were fed grain mixture (300 g daily containing 60% oats, 30% maize and 10% soybean meal as well as hay (ad libitum. The lambs were suckling and they received forage mixture, quality hay and fresh water ad libitum. During the summer feeding season ewes grazed on the pastures. The lambs were suckling and received forage mixture, quality hay ad libitum and pasture green mass in smaller portions. While comparing winter to summer feeding season the ewes had longer gravidity period (150.76 and 150.40 days, more lambs at parturition (1.21 and 1.11 and ablactation (1.10 and 1.07, more twins (12 and 8, higher body weight during gravidity (65.52 kg and 61.86 kg and increased body weight losses after lambing (7.72 kg and 6.44 kg. As for the body weight losses after lactation (7.94 kg and 7.78 kg no statistically significant differences were determined between the feeding seasons. Birth weight of lambs was higher by 26.91% (4.15 kg and 3.27 kg and at 60 days of age it was higher by 11.40% in winter compared to summer feeding season. Faster daily gains of lambs (by 7.21% was determined during the winter feeding season. However, it was noticed that lambs aged from 40th to 60th and 20th to 60th day obtained higher daily gains (by 6.25% and 1.74% in summer feeding season.

  16. Genetic parameters for ewe productivity traits in the Columbia, Suffolk and Targhee breeds.

    Science.gov (United States)

    Abdulkhaliq, A M; Harvey, W R; Parker, C F

    1989-12-01

    Estimates of repeatability and heritability were obtained for the following productivity traits of ewes: litter weight at birth (LWB) and weaning (LWW), litter size at birth (LSB), litter size alive at birth (NBA), litter size at weaning (LSW), neonatal survival rate (SRB) and preweaning survival rate (SRW). Phenotypic and genetic correlations were estimated for litter traits. The data set contained 6,394 ewe breeding records from three state stations over 10 yr on 1,731 ewes that were the progeny of 488 sires among three breeds (Columbia, Suffolk and Targhee). Pooled intra-station estimates of repeatability ranged from .11 to .22 for LWB and LWW among the three breeds. For litter size at birth, number born alive and litter size at weaning these estimates varied from .09 to .17 and for the survival traits (SRB and SRW) the variation was from .11 to .20. Intra-station estimates of heritability for the three breeds varied from .12 to .28 for LWB and LWW, and for LSB, NBA and LSW estimates varied from .05 to .35. Heritability estimates for survival traits (SRB and SRW) were low, ranging from .00 to .14. Phenotypic correlations among LWB, LWW, NBA and LSW ranged from .35 to .92 among the breed-station subclasses, with higher correlations occurring where a part-whole relationship existed. The study suggests that selection of ewes with high litter size at birth or at weaning and(or) litter weight at birth or at weaning will genetically improve total litter weight at weaning per ewe lambing.

  17. Ewing sarcoma EWS protein regulates midzone formation by recruiting Aurora B kinase to the midzone.

    Science.gov (United States)

    Park, Hyewon; Turkalo, Timothy K; Nelson, Kayla; Folmsbee, Stephen Sai; Robb, Caroline; Roper, Brittany; Azuma, Mizuki

    2014-01-01

    Ewing sarcoma is a malignant bone cancer that primarily occurs in children and adolescents. Eighty-five percent of Ewing sarcoma is characterized by the presence of the aberrant chimeric EWS/FLI1 fusion gene. Previously, we demonstrated that an interaction between EWS/FLI1 and wild-type EWS led to the inhibition of EWS activity and mitotic dysfunction. Although defective mitosis is considered to be a critical step in cancer initiation, it is unknown how interference with EWS contributes to Ewing sarcoma formation. Here, we demonstrate that EWS/FLI1- and EWS-knockdown cells display a high incidence of defects in the midzone, a midline structure located between segregating chromatids during anaphase. Defects in the midzone can lead to the failure of cytokinesis and can result in the induction of aneuploidy. The similarity among the phenotypes of EWS/FLI1- and EWS siRNA-transfected HeLa cells points to the inhibition of EWS as the key mechanism for the induction of midzone defects. Supporting this observation, the ectopic expression of EWS rescues the high incidence of midzone defects observed in Ewing sarcoma A673 cells. We discovered that EWS interacts with Aurora B kinase, and that EWS is also required for recruiting Aurora B to the midzone. A domain analysis revealed that the R565 in the RGG3 domain of EWS is essential for both Aurora B interaction and the recruitment of Aurora B to the midzone. Here, we propose that the impairment of EWS-dependent midzone formation via the recruitment of Aurora B is a potential mechanism of Ewing sarcoma development.

  18. Promoter Methylation Analysis Reveals that KCNA5 Ion Channel Silencing Supports Ewing Sarcoma Cell Proliferation

    Science.gov (United States)

    Ryland, Katherine E; Hawkins, Allegra G.; Weisenberger, Daniel J.; Punj, Vasu; Borinstein, Scott C.; Laird, Peter W.; Martens, Jeffrey R.; Lawlor, Elizabeth R.

    2015-01-01

    Polycomb proteins are essential regulators of gene expression in stem cells and development. They function to reversibly repress gene transcription via post-translational modification of histones and chromatin compaction. In many human cancers, genes that are repressed by polycomb in stem cells are subject to more stable silencing via DNA methylation of promoter CpG islands. Ewing sarcoma is an aggressive bone and soft tissue tumor that is characterized by over-expression of polycomb proteins. This study investigates the DNA methylation status of polycomb target gene promoters in Ewing sarcoma tumors and cell lines and observes that the promoters of differentiation genes are frequent targets of CpG-island DNA methylation. In addition, the promoters of ion channel genes are highly differentially methylated in Ewing sarcoma compared to non-malignant adult tissues. Ion channels regulate a variety of biological processes, including proliferation, and dysfunction of these channels contributes to tumor pathogenesis. In particular, reduced expression of the voltage-gated Kv1.5 channel has been implicated in tumor progression. These data show that DNA methylation of the KCNA5 promoter contributes to stable epigenetic silencing of Kv1.5 channel. This epigenetic repression is reversed by exposure to the DNA methylation inhibitor decitabine, which inhibits Ewing sarcoma cell proliferation through mechanisms that include restoration of Kv1.5 channel function. Implications This study demonstrates that promoters of ion channels are aberrantly methylated in Ewing sarcoma and that epigenetic silencing of KCNA5 contributes to tumor cell proliferation, thus providing further evidence of the importance of ion channel dyregulation to tumorigenesis. PMID:26573141

  19. Ewes Direct Most Maternal Attention towards Lambs that Show the Greatest Pain-Related Behavioural Responses

    Science.gov (United States)

    Futro, Agnieszka; Masłowska, Katarzyna; Dwyer, Cathy M.

    2015-01-01

    Although neonatal farm animals are frequently subjected to painful management procedures, the role of maternal behaviour in pain coping, has not been much studied. We investigated whether ewes were able to distinguish between lambs in pain and those that were not, and whether their behaviour altered depending on the severity of lamb pain. Eighty male lambs were allocated to one of 4 pain treatments within 24 hours of birth. Lambs were either handled only (C), bilaterally castrated with tight rubber rings (RR), as for RR but with the application of a Burdizzo clamp immediately proximal to the ring (Combined) or subjected to short scrotum castration (SSC) where the testicles were retained within the abdomen and only the scrotum removed. The behaviour of the ewe, treated lamb and untreated sibling where present (n = 54) were recorded for 30 minutes after treatment. Castration treatment increased the expression of abnormal standing and lying postures, specific pain-related behaviours (head-turning, stamping/kicking, easing quarters, tail wagging) and composite pain scores (P<0.001 for all). The greatest expression of pain-related behaviours was shown by lambs in the RR group, which were the only group to show rolling responses indicative of severe pain, followed by the SSC group. Ewes expressed more licking/sniffing responses to the RR and SSC lambs than towards the Combined and C lambs (P<0.05), and oriented most to RR lambs and least to C lambs (P<0.001). Ewes with two lambs also directed more attention towards the treated than the untreated lamb (P<0.001). The quantity of maternal care directed towards the lamb was positively correlated with the expression of active pain behaviours. The data demonstrate that ewes are able to discriminate between lambs in pain and those that are not, and that their response is increased with a greater severity of pain. PMID:26217942

  20. Influence of growth hormone on growth and onset of puberty ofRahmani ewe lamb

    Institute of Scientific and Technical Information of China (English)

    K H El-Shahat; N F Khaled; F I El-Far

    2014-01-01

    Objective:To study the effect of somatotropin administration on growth and puberty attainment of Rahmani ewes -lamb.Methods:TwelveRahmani ewes–lamb of6-7 months of age and average body weight(24.75±0.16) kg were randomly allotted into two equal groups.The first group served as control and the second group was somatotropin-treated.The ewe-lambs were weighed at the start and at the end of the experiment.In addition, the body condition score, withers height and heart girth were determined at the end of the study.Blood samples were collected weekly till the end of experiment(Twelve weeks).Sera samples were assayed for progesterone, insulin-like growth factor-1(IGF-1) glucose, total cholesterol, high density lipoprotein and urea.Results:It indicated that the somatotropin-treated group attained puberty2.5 weeks(18 days) earlier than control one.Somatotropin-treatedRahmani ewe lambs had higher body weight, and body condition score than those of the control one.A similar tendency was observed in average daily gain, withers height and heart girth.Somatotropin administration had a beneficial effect on blood born metabolites as indicated by increased serum glucose, total lipids, cholesterol,IGF-1 and decreased urea ofRahmani ewes- lamb as compared to control one.Conclusion:Somatotropin administration enhanced puberty inRahmani ewe lambs.This is due to increased provision of trophic signals(represented by increasedSerumIGF-1 secretions) and/or blood-borne metabolites(glucose, cholesterol and lipid).

  1. Ewes Direct Most Maternal Attention towards Lambs that Show the Greatest Pain-Related Behavioural Responses.

    Directory of Open Access Journals (Sweden)

    Agnieszka Futro

    Full Text Available Although neonatal farm animals are frequently subjected to painful management procedures, the role of maternal behaviour in pain coping, has not been much studied. We investigated whether ewes were able to distinguish between lambs in pain and those that were not, and whether their behaviour altered depending on the severity of lamb pain. Eighty male lambs were allocated to one of 4 pain treatments within 24 hours of birth. Lambs were either handled only (C, bilaterally castrated with tight rubber rings (RR, as for RR but with the application of a Burdizzo clamp immediately proximal to the ring (Combined or subjected to short scrotum castration (SSC where the testicles were retained within the abdomen and only the scrotum removed. The behaviour of the ewe, treated lamb and untreated sibling where present (n = 54 were recorded for 30 minutes after treatment. Castration treatment increased the expression of abnormal standing and lying postures, specific pain-related behaviours (head-turning, stamping/kicking, easing quarters, tail wagging and composite pain scores (P<0.001 for all. The greatest expression of pain-related behaviours was shown by lambs in the RR group, which were the only group to show rolling responses indicative of severe pain, followed by the SSC group. Ewes expressed more licking/sniffing responses to the RR and SSC lambs than towards the Combined and C lambs (P<0.05, and oriented most to RR lambs and least to C lambs (P<0.001. Ewes with two lambs also directed more attention towards the treated than the untreated lamb (P<0.001. The quantity of maternal care directed towards the lamb was positively correlated with the expression of active pain behaviours. The data demonstrate that ewes are able to discriminate between lambs in pain and those that are not, and that their response is increased with a greater severity of pain.

  2. Pregnancy stage and number of fetuses may influence maternal plasma leptin in ewes.

    Science.gov (United States)

    Kulcsár, Margit; Dankó, Gabriella; Magdy, H G I; Reiczigel, J; Forgach, T; Proháczik, Angella; Delavaud, Carole; Magyar, K; Chilliard, Y; Solti, L; Huszenicza, Gy

    2006-06-01

    Maternal plasma leptin is elevated in ewes during pregnancy. The authors studied whether there was any relation between maternal plasma leptin and insulin concentrations, the number of fetuses and the circulating and faecal levels of gestagens. At the end of the breeding season in January the ovarian activity of Prolific Merino ewes was induced/synchronised with gestagen + eCG treatment. Ewes were inseminated artificially (AI) by laparoscopy. Blood and faecal samples were collected before AI (day 0) and again 41, 81 and 101 days later. The plasma levels of leptin (pL), insulin and progesterone (pP4), and the faecal P4 metabolite (P4-met) content were determined. The day 0 level of pL was significantly higher in pregnant (n = 24) than in non-pregnant ewes (n = 32). By day 41 the pL of pregnant animals had doubled, it showed a further moderate increase on day 81, and decreased slightly thereafter. During pregnancy pP4 and faecal P4-met rose continuously and were positively correlated at all stages. The mean levels of pL and pP4 and the faecal content of P4-met were lower in ewes bearing single (n = 12) than in those with 2 (n = 6) or 3-5 fetuses (n = 6). Analysis of variance demonstrated significant differences according to the number of fetuses in the pL and pP4, but not in P4-met (p = 0.042, 0.044, and 0.051, respectively). Leptin showed positive correlation with insulin before the AI but not during pregnancy. On days 41 and 81 pL showed a slight positive correlation with P4 and P4-met, which decreased slightly by day 101. This study shows that although leptinaemia is affected by the number of fetuses and the level of P4, pregnancy stage is a more important regulator than these additional factors.

  3. Prevention of suckling improves postpartum reproductive responses to hormone treatments in Pelibuey ewes.

    Science.gov (United States)

    Ronquillo, Julio César Camacho; Martínez, Arturo Pró; Pérez, Carlos Miguel Becerril; Sandoval, Benjamín Figueroa; Martin, Graeme B; Valencia, Javier; Gallegos Sánchez, Jaime

    2008-08-01

    To determine the effects of suckling on postpartum (pp) reproductive efficiency in Pelibuey ewes, two experiments were performed. In Experiment 1, 112 ewes were randomly assigned to one of two groups at parturition: Without restriction of suckling (WRS) 24 h day(-1) for 60 days (n=56), and Weaned Ewes (WE), weaned at 40 days pp (n=56). On Day 30 pp, all ewes were given Prostaglandin (PGF2alpha) and one of four treatments (n=14): T1, intravaginal progestagen (FGA; 40 mg) for 12 days from day 30 pp+equine chorionic gonadotropin (eCG; 300 UI) until 2 days before removing FGA; T2, FGA was applied for 12 days; T3, a second application of PGF2alpha was given on day 40 pp+eCG on the same day; T4, a second injection of PGF2alpha was applied on day 40 pp only. In all the analyzed characteristics, the best results were obtained in WE. Within the WE group, the best treatment (P0.05) between RS and EW for the presentation of oestrus (96% vs. 92%), pregnancy (72% vs. 76%) or prolificacy (1.9 vs. 1.9), although group WRS did not perform (P<0.05) as well as groups RS and EW for any measure of performance. In conclusion, the combination of hormonal treatment (FGA plus eCG) with weaning at 7 or 40 days pp, or restricted suckling, improves postpartum reproductive efficiency in Pelibuey ewes, demonstrating the inhibitory role of suckling on postpartum reproduction in this breed.

  4. Protection by imidazol(ine) drugs and agmatine of glutamate-induced neurotoxicity in cultured cerebellar granule cells through blockade of NMDA receptor

    Science.gov (United States)

    Olmos, Gabriel; DeGregorio-Rocasolano, Nuria; Regalado, M Paz; Gasull, Teresa; Boronat, M Assumpció; Trullas, Ramón; Villarroel, Alvaro; Lerma, Juan; García-Sevilla, Jesús A

    1999-01-01

    This study was designed to assess the potential neuroprotective effect of several imidazol(ine) drugs and agmatine on glutamate-induced necrosis and on apoptosis induced by low extracellular K+ in cultured cerebellar granule cells.Exposure (30 min) of energy deprived cells to L-glutamate (1–100 μM) caused a concentration-dependent neurotoxicity, as determined 24 h later by a decrease in the ability of the cells to metabolize 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) into a reduced formazan product. L-glutamate-induced neurotoxicity (EC50=5 μM) was blocked by the specific NMDA receptor antagonist MK-801 (dizocilpine).Imidazol(ine) drugs and agmatine fully prevented neurotoxicity induced by 20 μM (EC100) L-glutamate with the rank order (EC50 in μM): antazoline (13)>cirazoline (44)>LSL 61122 [2-styryl-2-imidazoline] (54)>LSL 60101 [2-(2-benzofuranyl) imidazole] (75)>idazoxan (90)>LSL 60129 [2-(1,4-benzodioxan-6-yl)-4,5-dihydroimidazole] (101)>RX821002 (2-methoxy idazoxan) (106)>agmatine (196). No neuroprotective effect of these drugs was observed in a model of apoptotic neuronal cell death (reduction of extracellular K+) which does not involve stimulation of NMDA receptors.Imidazol(ine) drugs and agmatine fully inhibited [3H]-(+)-MK-801 binding to the phencyclidine site of NMDA receptors in rat brain. The profile of drug potency protecting against L-glutamate neurotoxicity correlated well (r=0.90) with the potency of the same compounds competing against [3H]-(+)-MK-801 binding.In HEK-293 cells transfected to express the NR1-1a and NR2C subunits of the NMDA receptor, antazoline and agmatine produced a voltage- and concentration-dependent block of glutamate-induced currents. Analysis of the voltage dependence of the block was consistent with the presence of a binding site for antazoline located within the NMDA channel pore with an IC50 of 10–12 μM at 0 mV.It is concluded that imidazol(ine) drugs and agmatine are

  5. Les sources de protéines dans l’alimentation du bétail en France : la place des oléoprotéagineux

    Directory of Open Access Journals (Sweden)

    Peyronnet Corinne

    2014-07-01

    Full Text Available En France, les aliments concentrés totalisent 30 millions de tonnes de matières premières parmi lesquelles 64 % sont des céréales et 22 % des tourteaux d’oléagineux. Le déficit français en matières riches en protéines (dosant plus de 15 % de protéines qui était d’environ 70 % dans les années 1980 a baissé en dessous de 40 % successivement grâce au développement du pois dans les années 1990 puis du colza depuis les années 2000 avec des surfaces totales cultivées de 2,5 millions d’hectares environ. Le tourteau de soja reste le premier tourteau utilisé en France mais ses importations baissent, notamment depuis 2009, et il n’a représenté que 3,3 millions de tonnes sur la campagne 2012/2013. L’utilisation du tourteau de soja non OGM diminue également avec 0,6 million de tonnes en 2012 contre 1,2 en 2002. Les tourteaux de colza et tournesol ont quant à eux atteint respectivement 2,3 et 1,4 millions de tonnes en 2012/2013 parmi lesquels 700 000 tonnes de tourteau de tournesol High pro (à 36 % de protéines importées de la zone Mer noire et 600 000 tonnes de différentes qualités produites en France. Depuis 2013, des tourteaux de tournesol High pro sont également produits en France à Bassens. Les prix des MRP suivent le marché mondial du tourteau de soja mais la demande française pour des matières premières non OGM permet une meilleure valorisation des sources de protéines locales.

  6. Ispitivanja uticaja srednjeg masenog udela azota u nitrocelulozii veličine čestica modifikatora na brzine sagorevanja dvobaznih raketnih goriva

    OpenAIRE

    Maslak Panto; Tot Lajoš

    2002-01-01

    Istraživana je katalitička aktivnost balističkih modifikatora: baznog olovo-stearata, kalcijum-karbonata, kobalt (IH)-oksida i čadi, za različite masene udele azota u nitrocelulozi, kao komponenti dvobaznog raketnog goriva, kao i uticaj veličine čestica balističkih modifikatora na brzinu sagorevanja dvobaznih raketnih goriva. Kao mera katalitičke aktivnosti korišćen je koeficijent katalitičke aktivnosti, koji predstavlja odnos brzine sagorevanja referentnog modela dvobaznog raketnog goriva sa...

  7. Modernization projects in Santa Maria e Garona; Proyectos de modernizacion en Santa Maria de Garona

    Energy Technology Data Exchange (ETDEWEB)

    Marcos, R.; Alutiz, J. I.; Garcia Sanchez, M.

    2011-07-01

    This article shows a vision of the Santa Maria de Garona power Plant modernization guidelines and it also presents the most significant projects deployed in the last decade at the power plant grouped in mechanics projects, electrical projects, instrumentations projects and IT projects. At the same time three projects are explained in more detail: the change of one of the main transformers, the evolution from paper recorders to paperless video graphic recorders and the new plant data information system. (Author)

  8. Risky Bu$ine$$

    Science.gov (United States)

    Galuszka, Peter

    2006-01-01

    Hedge funds are the rock stars of today's financial world. These slightly regulated pools of equity, which are open only to rich players, are managed through secretive and sophisticated investment strategies. Although the risks are high, so are the potential benefits. Despite the risks, many colleges and universities have chosen to invest heavily…

  9. Imag(ining Sardinia

    Directory of Open Access Journals (Sweden)

    Giorgia Alù

    2014-12-01

    Full Text Available Review of: Maria Bonaria Urban, Sardinia on Screen. The Construction of the Sardinian Character in Italian Cinema, Amsterdam–New York, Rodopi, 579 p., 2013, ISBN: 9789042037502, € 120 / US$ 168; eBook: 9789401210010, € 108 / US$ 151.

  10. Santa Barbara Cluster Comparison Test with DISPH

    CERN Document Server

    Saitoh, Takayuki

    2016-01-01

    The Santa Barbara cluster comparison project (Frenk et al. Frenk+1999) revealed that there is a systematic difference between entropy profiles of clusters of galaxies obtained by Eulerian mesh and Lagrangian smoothed particle hydrodynamics (SPH) codes: Mesh codes gave a core with a constant entropy whereas SPH codes did not. One possible reason for this difference is that mesh codes are not Galilean invariant. Another possible reason is the problem of the SPH method, which might give too much "protection" to cold clumps because of the unphysical surface tension induced at contact discontinuities. In this paper, we apply the density independent formulation of SPH (DISPH), which can handle contact discontinuities accurately, to simulations of a cluster of galaxies, and compare the results with those with the standard SPH. We obtained the entropy core when we adopt DISPH. The size of the core is, however, significantly smaller than those obtained with mesh simulations, and is comparable to those obtained with qu...

  11. Computer Security: a plea to Santa Claus

    CERN Multimedia

    Stefan Lueders, Computer Security Team

    2015-01-01

    Running pirated software or illegal licences, using cracking tools to bypass software activation measures, sharing music and films – these are problems that academic environments unfortunately have to deal with. All violate the copyright of the software/music/film owners, and copyright owners are not Santa Claus...    CERN, like other research organisations and universities, regularly receives allegations from external companies complaining about laptops or PCs running illegal software or sharing their films, videos or music with peers – and thus violating copyright.  Usually, we then contact the owners of the corresponding devices in order to understand whether these allegations are true. Very often such allegations boil down to a laptop whose owner replies “I confirm that a torrent client was left up and running on my device by mistake” or “This is a file that is stored on my personal hard disk.” As if those allegatio...

  12. Hyundai Santa Fe 2.7

    Institute of Scientific and Technical Information of China (English)

    田永梁

    2005-01-01

    Santa Fe无疑现代最强壮结实的汽车,它的自信与果断,让它成为现代汽车当之无愧的大哥。桀骜不驯的造型、怪异的线条、自信果断。虽然颇受争议,但依然是一副毁誉由人的态度。不过,无论你是喜欢还是不喜欢,你都只需要看它一眼就知道:这是现代汽车。

  13. Use of cactus pear (Opuntia ficus indica Mill replacing corn on carcass characteristics and non-carcass components in Santa Inês lambs Utilização da palma forrageira (Opuntia fícus-indica Mill em substituição ao milho sobre as características de carcaça e componentes não constituintes da carcaça de cordeiros da raça Santa Inês

    Directory of Open Access Journals (Sweden)

    Tiago Ferreira Pinto

    2011-06-01

    Full Text Available The objective of this study was to evaluate the biometric and morphometric measures, regional composition, carcass characteristics and non-carcass components of Santa Inês lambs submitted to levels of corn replaced by cactus pear in the diet. It was used 45 Santa Ines non-castrated male lambs, with average initial live weight of 25.50 ± 0.48 kg as a completely randomized block design with five treatments (0; 25; 50; 70 and 100% and nine replicates. There was an effect of the diet on slaughter weight, empty body weight, hot and cold carcass, cold carcass weight, shoulder weight and loin weight. Cactus pear can replace up to 75% of corn in diets for feedlot Santa Inês lambs, without compromising production, carcass characteristics and production of non-carcass components.O objetivo neste trabalho foi avaliar as medidas biométricas e morfométricas, a composição regional, as características de carcaça e os componentes não constituintes da carcaça de cordeiros Santa Inês, submetidos a níveis de substituição do milho por palma forrageira na dieta. Foram utilizados 45 cordeiros não-castrados da raça Santa Inês com peso vivo inicial de 25,0 ± 0,48 kg, distribuídos em delineamento de blocos ao acaso com cinco tratamentos (0; 25; 50; 75 e 100% e nove repetições. Houve efeito da dieta sobre o peso ao abate, peso do corpo vazio, peso de carcaça quente e fria, peso da paleta e peso do lombo. A palma forrageira pode substituir até 75% do milho em dietas para cordeiros da raça santa Inês em confinamento, sem comprometer a produção, as características da carcaça e a produção de componentes não constituintes da carcaça.

  14. Early Neogene unroofing of the Sierra Nevada de Santa Marta along the Bucaramanga -Santa Marta Fault

    Science.gov (United States)

    Piraquive Bermúdez, Alejandro; Pinzón, Edna; Bernet, Matthias; Kammer, Andreas; Von Quadt, Albrecht; Sarmiento, Gustavo

    2016-04-01

    Plate interaction between Caribbean and Nazca plates with Southamerica gave rise to an intricate pattern of tectonic blocks in the Northandean realm. Among these microblocks the Sierra Nevada de Santa Marta (SNSM) represents a fault-bounded triangular massif composed of a representative crustal section of the Northandean margin, in which a Precambrian to Late Paleozoic metamorphic belt is overlain by a Triassic to Jurassic magmatic arc and collateral volcanic suites. Its western border fault belongs to the composite Bucaramanga - Santa Marta fault with a combined left lateral-normal displacement. SE of Santa Marta it exposes remnants of an Oligocene marginal basin, which attests to a first Cenoizoic activation of this crustal-scale lineament. The basin fill consists of a sequence of coarse-grained cobble-pebble conglomerates > 1000 m thick that unconformably overlay the Triassic-Jurassic magmatic arc. Its lower sequence is composed of interbedded siltstones; topwards the sequence becomes dominated by coarser fractions. These sedimentary sequences yields valuable information about exhumation and coeval sedimentation processes that affected the massif's western border since the Upper Eocene. In order to analyse uplifting processes associated with tectonics during early Neogene we performed detrital zircon U-Pb geochronology, detrital thermochronology of zircon and apatites coupled with the description of a stratigraphic section and its facies composition. We compared samples from the Aracataca basin with analog sequences found at an equivalent basin at the Oca Fault at the northern margin of the SNSM. Our results show that sediments of both basins were sourced from Precambrian gneisses, along with Mesozoic acid to intermediate plutons; sedimentation started in the Upper Eocene-Oligocene according to palynomorphs, subsequently in the Upper Oligocene a completion of Jurassic to Cretaceous sources was followed by an increase of Precambrian input that became the dominant

  15. Actuarial risk of isolated CNS involvement in Ewing's sarcoma following prophylactic cranial irradiation and intrathecal methotrexate

    Energy Technology Data Exchange (ETDEWEB)

    Trigg, M.E.; Makuch, R.; Glaubiger, D.

    1985-04-01

    Records of 154 patients with Ewing's sarcoma treated at the National Cancer Institute were reviewed to assess the incidence and risk of developing isolated central nervous system (CNS) Ewing's sarcoma. Sixty-two of the 154 patients had received CNS irradiation and intrathecal (i.t.) methotrexate as part of their initial therapy to prevent the occurrence of isolated CNS Ewing's sarcoma. The risk of developing isolate CNS Ewing's sarcoma was greatest within the first two years after diagnosis and was approximately 10%. The overall risk of CNS recurrence in the group of patients receiving DNS treatment was similar to the group receiving no therapy directed to the CNS. The occurrence of isolated CNS involvement was not prevented by the use of CNS irradiation and i.t. methotrexate. Because of a lack of efficacy to the CNS irradiation regimen, current treatment regimens do not include therapy directed to CNS.

  16. Immunological effects of feeding macroalgae and various vitamin E supplements in Norwegian white sheep-ewes and their offspring

    DEFF Research Database (Denmark)

    Novoa-Garrido, M; Aanensen, L; Lind, V

    2014-01-01

    It is assumed that ewes raised in areas with long indoor winter feeding periods need to be supplemented with vitamins or other substances that help to maintain the health status of the animals. Various supplements are available on the market, but the most widely used supplemental antioxidant...... for small ruminants. Sources tested were meal of the seaweed Ascophylum nodosum and natural RRR-α-tocopheryl acetate. Forty pregnant ewes were randomly allocated to four treatment group with two replicates (5 ewes in each replicate). The treatments were supplements containing seaweed (SW: 546 g Ascophylum...... nodosum/kg), natural vitamin E (NatE: 562.5 mg RRR-α-tocopheryl acetate/kg), synthetic vitamin E (SyntE: 1125 mg all-rac-α-tocopheryl acetate/kg), or no extra seaweed or vitamin E (control). The supplements were fed at an isoenergetic daily rate, on average 144 g DM/ewe for SW and 114 g DM...

  17. Poisoning by Ipomoea asarifolia in lambs by the ingestion of milk from ewes that ingest the plant.

    Science.gov (United States)

    Carvalho de Lucena, Kleber F; Rodrigues, Jussara M N; Campos, Édipo M; Dantas, Antônio F M; Pfister, James A; Cook, Daniel; Medeiros, Rosane M T; Riet-Correa, Franklin

    2014-12-15

    Two experiments, each with 10 pregnant ewes (8 treated and 2 controls) were performed to determine if nursing lambs of lactating ewes become intoxicated when the ewes ingest Ipomoea asarifolia but do not show clinical signs themselves. In the first experiment the sheep grazed I. asarifolia in the field while in the second, sheep were maintained in individual bays consuming dry I. asarifolia at 10% and 20% into their ration. In both experiments the lambs remained confined, consuming only their mother's milk. Four of 8 lambs in the grazing experiment and the 4 nursing lambs from the ewes given 20% I. asarifolia showed signs of I. asarifolia poisoning. These results confirm that the tremorgenic compound of I. asarifolia or its toxic metabolites are eliminated in milk and can intoxicate nursing lambs.

  18. Aggressive Ewing's sarcoma appearing as a cold lesion on bone scan; Sarcome d'Ewing agressif apparaissant comme une lesion froide sur la scintigraphie osseuse

    Energy Technology Data Exchange (ETDEWEB)

    Chatti, K.; Guezguez, M.; Maha Ben Fredj, M.; Sfar, R.; Essabbah, H. [Hopital Universitaire de Sahloul, Dept. de Medecine Nucleaire, Sahloul (Tunisia); Mtaoumi, M. [Hopital Universitaire de Sahloul, Dept. d' Orthopedie, Sousse (Tunisia); Chatti, K. [Faculte de Medecine de Monastir, Lab. de Biophysique, Monastir (Tunisia)

    2009-10-15

    Ewing's sarcoma classically presents as a hot spot on bone scan as a result of increased vascularity of the tumor and new bone formation. Purpose We report and analyze an uncommon pattern of a 'cold' lesion in Ewing's sarcoma on bone scan and its pathophysiologic significance. Case report A 15-year-old boy complaining of thigh pain. CT scan evoked Ewing's sarcoma or osteitis. MRI evoked chronic osteitis. Scintigraphy showed a fairly intense and heterogeneous uptake on the femoral lesion and no abnormal uptake elsewhere. Biopsy showed none pathologic pattern. Three months later, a second biopsy concluded to Ewing's sarcoma. Bone scan showed a larger lesion with peripheral intense uptake centered by enlarged 'cold' area in the left femoral diaphysis and no evident bone metastasis. The patient underwent chemotherapy and surgery. Three months later, bone scan showed extensive skeletal metastasis. Conclusion Ewing's sarcoma appears usually as an intense lesion on bone scan. Nevertheless, decreased radiopharmaceutical uptake or 'cold' lesion may be seen in aggressive Ewing's sarcoma with lytic tumor, growth of which is very rapid and bony reaction is minimal. (authors)

  19. Effect of balanced concentrate ration on the performance and hematobiochemical profile of lactating native ewes and lambs in coastal Odisha

    Directory of Open Access Journals (Sweden)

    Sasanka Sekhar Beura

    2014-12-01

    Full Text Available Aim: The present study was conducted to evaluate the effect of supplementation of balanced concentrate ration during lactation on the growth performance, blood and metabolic profiles of native ewes and lambs in coastal Odisha. Materials and Methods: A total of 40 numbers of lactating ewes of the same parity comprised the experimental animals. The selected ewes were randomly assigned to two groups of twenty each, maintaining uniformity in body weight (13.36±0.33 kg for Group 1 and 13.48±0.37 kg for Group 2. Group 1 was maintained on grazing only while Group 2 was supplemented with a balanced concentrate mixture @ 200 g/head/day during the first 2 months of lactation. The concentrate was fed individually in separate containers in the morning hours before the animals were taken out for grazing. Results: The ewes in Group 2 registered higher body weights at every fortnight. The differences were found to be highly significant (p<0.01 from 2nd to 5th fortnight and significant (p<0.05 for the remaining fortnights. The ewes in Group 2 showed significantly (p<0.01 higher daily gains than those in Group 1 at every fortnight. The hemoglobin (Hb concentration, mean cell hemoglobin (MCH and total leukocyte count (TLC values were significant (p<0.05 between groups at the end of 4th fortnight after lambing and the mean cell hemoglobin concentration (MCHC values is significantly (p<0.05 higher in Group 2 over Group 1. Conclusion: It was concluded that supplementation of a balanced concentrate mixture (crude protein 18.21% @ 200 g/ewe/day along with grazing during the first 2 months of lactation resulted in higher ewe body weight gain. It improved their hematological and metabolic profiles and also resulted in higher body weight gain in lambs born to these supplemented ewes.

  20. Sodium chlorate reduces presence of Escherichia coli in feces of lambs and ewes managed in shed-lambing systems

    Science.gov (United States)

    Our objective was to establish doses of orally-administered NaClO3 that reduced presence of generic Escherichia coli in intestines of ewes and neonatal lambs managed in a shed-lambing system. Neonatal lambs (n = 32; age = 7.1 ± 1.2 d; BW = 6.8 ± 1.0 kg) and yearling ewes (n = 44; BW = 74.8 ± 5.6 kg)...

  1. Endocrine and Ovarian Changes in Response to the Ram Effect in Medroxyprogesterone Acetate-primed Corriedale Ewes During the Breeding and Nonbreeding Season

    Directory of Open Access Journals (Sweden)

    Rubianes E

    2005-03-01

    Full Text Available Two experiments were performed to determine the endocrine and ovarian changes in medroxyprogesterone acetate (MAP-primed ewes after ram introduction. Experiment 1 was performed during the mid-breeding season with 71 ewes primed with an intravaginal MAP sponge for 12 days. While the control (C ewes (n = 35 were in permanent contact with rams, the ram effect (RE ewes (n = 36 were isolated for 34 days prior to contact with rams. At sponge withdrawal, all ewes were joined with eight sexually experienced marking Corriedale rams and estrus was recorded over the next 4 days. The ovaries were observed by laparoscopy 4–6 days after estrus. Four weeks later, pregnancy was determined by transrectal ultrasonography. In eight ewes from each group, ovaries were ultrasonographically scanned; FSH, LH, and estradiol-17β were measured every 12 hours until ovulation or 96 hours after estrus. The response to the rams was not affected by the fact that ewes had been kept or not in close contact with males before teasing. No differences were found in FSH, LH, estradiol-17β concentrations, growth of the ovulatory follicle, onset of estrus, ovulation rate, or pregnancy rate. Experiment 2 was performed with 14 ewes during the nonbreeding season. Ewes were isolated from rams for 1 month, and received a 6-day MAP priming. Ovaries were ultrasonographically scanned every 12 hours, and FSH, LH, estradiol-17β, and progesterone were measured. Ewes that ovulated and came into estrus had higher FSH and estradiol-17β levels before introduction of the rams than did ewes that had a silent ovulation. The endocrine pattern of the induced follicular phase of ewes that came into estrus was more similar to a normal follicular phase, than in ewes that had a silent ovulation. The follicle that finally ovulated tended to emerge earlier and in a more synchronized fashion in those ewes that did come into estrus. All ewes that ovulated had an LH surge and reached higher maximum FSH

  2. Design, synthesis and anticancer activity of diam(m)ine platinum(II) complexes bearing a small-molecular cell apoptosis inducer dichloroacetate.

    Science.gov (United States)

    Liu, Weiping; Jiang, Jing; Xu, Yongping; Hou, Shuqian; Sun, Liping; Ye, Qingsong; Lou, Liguang

    2015-05-01

    Four new diam(m)ine platinum complexes containing the dichloroacetate moiety in 3-dichoroacetoxylcyclobutane-1,1-dicarboxylate as the leaving group were synthesized, characterized by elemental analysis as well as by ESI(+)-MS (electrospray ionization mass spectrometry in positive mode), FT-IR, (1)H- and (13)C-NMR, and evaluated for their in vitro anticancer activity against human lung cancer cell line (A549) and ovarian cancer cell lines (SK-OV-3, SK-OV-3/DDP). Diam(m)ines used in the present study belong to the carriers of six clinically approved platinum drugs. Among the complexes synthesized, complex 2, cis-[Pt(II)(1R,2R-diaminocyclohexane)·(3-dichoroacetoxylcyclobutane-1,1-dicarboxylate)] is the most promising in terms of water solubility and potential of being totally devoid of cross-drug resistance with cisplatin. Therefore, complex 2 was selected for the dichloroacetate release test. The test shows dichloroacetate can be efficiently released from complex 2 under physiological conditions via the hydrolysis of an ester bond bridging the dichloroacetate moiety and platinum pharmacophores together. Our study supports the further evaluation of this complex as a drug candidate.

  3. Extrapolated withdrawal-interval estimator (EWE) algorithm: a quantitative approach to establishing extralabel withdrawal times.

    Science.gov (United States)

    Martín-Jiménez, Tomás; Baynes, Ronald E; Craigmill, Arthur; Riviere, Jim E

    2002-08-01

    The extralabel use of drugs can be defined as the use of drugs in a manner inconsistent with their FDA-approved labeling. The passage of the Animal Medicinal Drug Use Clarification Act (AMDUCA) in 1994 and its implementation by the FDA-Center for Veterinary Medicine in 1996 has allowed food animal veterinarians to use drugs legally in an extralabel manner, as long as an appropriate withdrawal period is established. The present study introduces and validates with simulated and experimental data the Extrapolated Withdrawal-Period Estimator (EWE) Algorithm, a procedure aimed at predicting extralabel withdrawal intervals (WDIs) based on the label and pharmacokinetic literature data contained in the Food Animal Residue Avoidance Databank (FARAD). This is the initial and first attempt at consistently obtaining WDI estimates that encompass a reasonable degree of statistical soundness. Data on the determination of withdrawal times after the extralabel use of the antibiotic oxytetracycline were obtained both with simulated disposition data and from the literature. A withdrawal interval was computed using the EWE Algorithm for an extralabel dose of 25 mg/kg (simulation study) and for a dose of 40 mg/kg (literature data). These estimates were compared with the withdrawal times computed with the simulated data and with the literature data, respectively. The EWE estimates of WDP for a simulated extralabel dose of 25 mg/kg was 39 days. The withdrawal time (WDT) obtained for this dose on a tissue depletion study was 39 days. The EWE estimate of WDP for an extralabel intramuscular dose of 40 mg/kg in cattle, based on the kinetic data contained in the FARAD database, was 48 days. The withdrawal time experimentally obtained for similar use of this drug was 49 days. The EWE Algorithm can obtain WDI estimates that encompass the same degree of statistical soundness as the WDT estimates, provided that the assumptions of the approved dosage regimen hold for the extralabel dosage regimen

  4. Effect of Moxidectin Treatment at Peripartum on Gastrointestinal Parasite Infections in Ewes Raised under Tropical Andes High Altitude Conditions

    Directory of Open Access Journals (Sweden)

    J. J. Vargas-Duarte

    2015-01-01

    Full Text Available This study tested the impact of moxidectin at peripartum on nematode fecal egg count (FEC and clinical parameters on ewes in the high altitude tropical Andes of Colombia. FEC and clinical evaluations were performed on 9 occasions in 43 naturally infected ewes before and during gestation and after lambing. Moxidectin (Mox, 200 µg kg−1 was applied at late pregnancy (T1, n=15 or 48 hours after parturition (T2, n=14. 14 untreated ewes served as controls (C. Suckling lambs (n=58 remained untreated and underwent four clinical and parasitological evaluations until 8 weeks after birth. Mox efficacy equaled 99.3% (T1 and 96.9% (T2. Highest mean FEC value reflecting periparturient nematode egg rise (PPER was recorded in C ewes at 4–6 weeks after lambing. Significant FEC reductions were found in T1 (94.8% and T2 (96.7% ewes (p<0.05. All lambs showed a significant and ewes-group independent increase in FEC before weaning (p<0.05. Clinical parameters (anemia and diarrhea showed time- and treatment-related differences (p<0.05. Monitoring of FEC and clinical parameters linked to gastrointestinal parasite infections allowed demonstrating that postpartum or preweaning are two critical periods to nematode infection for sheep raised under tropical Andes high altitude conditions. Use of Mox as anthelmintic treatment prevented PPER.

  5. The Macrophage Inhibitor CNI-1493 Blocks Metastasis in a Mouse Model of Ewing Sarcoma through Inhibition of Extravasation.

    Directory of Open Access Journals (Sweden)

    Anthony J Hesketh

    Full Text Available Metastatic Ewing Sarcoma carries a poor prognosis, and novel therapeutics to prevent and treat metastatic disease are greatly needed. Recent evidence demonstrates that tumor-associated macrophages in Ewing Sarcoma are associated with more advanced disease. While some macrophage phenotypes (M1 exhibit anti-tumor activity, distinct phenotypes (M2 may contribute to malignant progression and metastasis. In this study, we show that M2 macrophages promote Ewing Sarcoma invasion and extravasation, pointing to a potential target of anti-metastatic therapy. CNI-1493 is a selective inhibitor of macrophage function and has shown to be safe in clinical trials as an anti-inflammatory agent. In a xenograft mouse model of metastatic Ewing Sarcoma, CNI-1493 treatment dramatically reduces metastatic tumor burden. Furthermore, metastases in treated animals have a less invasive morphology. We show in vitro that CNI-1493 decreases M2-stimulated Ewing Sarcoma tumor cell invasion and extravasation, offering a functional mechanism through which CNI-1493 attenuates metastasis. These data indicate that CNI-1493 may be a safe and effective adjuvant agent for the prevention and treatment of metastatic Ewing Sarcoma.

  6. Fertility Rates of Ewes Treated with Medroxyprogesterone and Injected with Equine Chorionic Gonadotropin plus Human Chorionic Gonadotropin in Anoestrous Season

    Directory of Open Access Journals (Sweden)

    I. W. Santos

    2010-01-01

    Full Text Available The aim of the present paper was to investigate the efficiency of the equine chorionic gonadotropin (eCG plus human chorionic gonadotropin (hCG associated with medroxyprogesterone acetate (MAP to estrous ewes synchronization. Ninety Texel ewes were investigated during seasonal anoestrous. The ewes received intravaginal sponges containing MAP (60 mg for nine days. At the time of sponges' withdrawal, the ewes were divided into three groups (G: (1 receiving 2 mL of saline i.m. (n=30, (2 receiving eCG 400 IU i.m. (n=30, and (3 receiving eCG 400 IU plus hCG 200 IU i.m. (n=30. Twelve h after sponges' removal, teaser rams were used to estrus check and remained with the ewes for 96 h. The artificial insemination was made with fresh semen 10 h after estrus detection. The effect of the treatment was not significant for the estrous rates among the groups: 73%, 90%, and 86%, respectively. The main effect was observed in the pregnancy and lambing rates among the groups: 70%, 86%, 56%, and 80%, 120%, 56%, respectively. Based on these results from our study, the use of the MAP—eCG is the best choice to improve the fertility rate on ewes.

  7. Effect of Moxidectin Treatment at Peripartum on Gastrointestinal Parasite Infections in Ewes Raised under Tropical Andes High Altitude Conditions

    Science.gov (United States)

    Vargas-Duarte, J. J.; Lozano-Márquez, H.; Grajales-Lombana, H. A.; Manrique-Perdomo, C.; Martínez-Bello, D. A.; Saegerman, C.; Raes, M.; Kirschvink, N.

    2015-01-01

    This study tested the impact of moxidectin at peripartum on nematode fecal egg count (FEC) and clinical parameters on ewes in the high altitude tropical Andes of Colombia. FEC and clinical evaluations were performed on 9 occasions in 43 naturally infected ewes before and during gestation and after lambing. Moxidectin (Mox, 200 µg kg−1) was applied at late pregnancy (T1, n = 15) or 48 hours after parturition (T2, n = 14). 14 untreated ewes served as controls (C). Suckling lambs (n = 58) remained untreated and underwent four clinical and parasitological evaluations until 8 weeks after birth. Mox efficacy equaled 99.3% (T1) and 96.9% (T2). Highest mean FEC value reflecting periparturient nematode egg rise (PPER) was recorded in C ewes at 4–6 weeks after lambing. Significant FEC reductions were found in T1 (94.8%) and T2 (96.7%) ewes (p < 0.05). All lambs showed a significant and ewes-group independent increase in FEC before weaning (p < 0.05). Clinical parameters (anemia and diarrhea) showed time- and treatment-related differences (p < 0.05). Monitoring of FEC and clinical parameters linked to gastrointestinal parasite infections allowed demonstrating that postpartum or preweaning are two critical periods to nematode infection for sheep raised under tropical Andes high altitude conditions. Use of Mox as anthelmintic treatment prevented PPER. PMID:26078913

  8. Safety and efficacy of reduced doses of Brucella melitensis strain Rev. 1 vaccine in pregnant Iranian fat-tailed ewes.

    Science.gov (United States)

    Ebrahimi, Mohammad; Nejad, Ramin Bagheri; Alamian, Saeed; Mokhberalsafa, Ladan; Abedini, Fatemeh; Ghaderi, Rainak; Jalali, Hamid Reza

    2012-01-01

    Brucellosis is one of the most important zoonotic diseases and is a significant cause of abortion in animals. Brucella melitensis strain Rev. 1 is recommended as the most effective vaccine for small ruminants but the application of full doses in adult animals is restricted. This study was conducted to determine a proper reduced dose of vaccine which confers protection but which is not abortifacient in Iranian fat-tailed sheep. A total of 51 non-vaccinated pregnant ewes were divided into three main groups and several subgroups. Ewes in different groups were vaccinated at different stages of pregnancy and various subgroups were subcutaneously immunised with different quantities of the micro-organism (7.5 × 10(6), 10(6), 5 × 10(5)). Ewes again became pregnant a year later and were challenged with the wild-type strain to evaluate the protection conferred. Results revealed that the proportion of vaccination-induced abortions was significantly higher in ewes immunised with 7.5 × 10(6) Rev. 1 organisms than in those which received 10(6) or 5 × 10(5) bacteria. While 80% of non-vaccinated ewes aborted after challenge, none of the vaccinated ewes aborted post-challenge. This study indicated that a reduced dose of Rev. 1 vaccine containing 10(6) or 5 × 10(5) live cells could be safely used to induce protection in Iranian fat-tailed sheep at various stages of pregnancy.

  9. The relationship between trace mineral concentrations of amniotic fluid with placentatraits in the pregnancy toxemia Ghezel ewes

    Institute of Scientific and Technical Information of China (English)

    Ali Olfati; Gholamali Moghaddam; Nasroallah Moradi Kor; Behzad Baradaran

    2016-01-01

    Objective: This study was conducted to investigate the trace mineral concentrations (Mg, Se, Zn, Cu and Fe) in amniotic fluid (AF) in 40 pregnancy toxemia Ghezel ewes at the time of parturition phase and its association with placental traits. Methods: Animals were treated with controlled internal drug release for 14 d and injected 400 IU pregnant mare serum gonadotropin at the time of controlled internal drug release removal. After the detection of estrus by use of teaser rams, ewes were hand-mated. Ewes were classified as having subclinical pregnancy toxemia on the basis of beta-hydroxy butyrate (BHBA) results (BHBA >0.86 mmol/L). Results: The overall mean AF traces of mineral concentrations were 3.13 ng/mL, 22.1 μg/dL, 134.7 μg/dL, 122.5 μg/dL and 166.6 μg/dL, respectively. There was a significant positive correlation between placental efficiency and Zn concentration in AF ewes (r = 0.633, P 0.01), except for placental weight (r = 0.808, P < 0.01). Also, no significant correlation was detected between BHBA with the above trace minerals. Conclusions:Overall, determinations of these trace minerals in the AF ewes could have been used to obtain information on nutritional and reproductive status for the diagnosis of pregnancy toxemia in Ghezel ewes.

  10. Interactions between metabolic status, pre-breeding protein supplementation, uterine pH, and embrionic mortality in ewes: preliminary observations.

    Science.gov (United States)

    Meza-Herrera, C A; Ross, T; Hawkins, D; Hallford, D

    2006-07-01

    The effect of prebreeding short-term protein supplementation level (PL) and body condition (BC) on fertility rate (FERT,%), uterine pH and embryonic mortality (EMORT,%) in sheep, was evaluated. Multiparous Rambouillet ewes at low BC (LC; n = 6, 62.7+/-1.7 kg) or high BC (HC; n = 6, 71.9 +/-1.7 kg), received, within BC, one of two levels of ruminally undegradable protein: low (LP, 14 g/ewe per day) and high (HP, 30 g/ewe per day). Once the animals were euthanized, corpus luteum number (CLN), as an indicator of ovulation rate, was registered and uterine horns were irrigated to recover embryonic tissue plus associated membranes as well as to measure uterine pH (UpH). While EMORT- 1 considered a nonadjusted relationship between the number of embryos and CLN, EMORT-2 considered an analysis of covariance using CLN as the covariate. The HP-supplemented ewes had the lowest FERT (p = 0.06; 100% vs 50%) and the highest EMORT (EMORT-1, 16.6% vs 53.8%, p = 0.08; EMORT-2, 52.0% vs 14.5%, p = 0.07) when compared to the LP-supplemented ewes. Neither BC nor PL affected CLN, CL weight or P4 release (p > 0.10). While the lowest UpH (p = 0.04) was observed in the HP-supplemented ewes, this group also showed the lowest fertility and the highest embryonic mortality.

  11. Safety and efficacy of reduced doses of Brucella melitensis strain Rev. 1 vaccine in pregnant Iranian fat-tailed ewes

    Directory of Open Access Journals (Sweden)

    Mohammad Ebrahimi

    2012-12-01

    Full Text Available Brucellosis is one of the most important zoonotic diseases and is a significant cause of abortion in animals. Brucella melitensis strain Rev. 1 is recommended as the most effective vaccine for small ruminants but the application of full doses in adult animals is restricted. This study was conducted to determine a proper reduced dose of vaccine which confers protection but which is not abortifacient in Iranian fat-tailed sheep. A total of 51 non-vaccinated pregnant ewes were divided into three main groups and several subgroups. Ewes in different groups were vaccinated at different stages of pregnancy and various subgroups were subcutaneously immunised with different quantities of the micro-organism (7.5 × 106, 106, 5 × 105. Ewes again became pregnant a year later and were challenged with the wild-type strain to evaluate the protection conferred. Results revealed that the proportion of vaccination-induced abortions was significantly higher in ewes immunised with 7.5 × 106 Rev. 1 organisms than in those which received 106 or 5 × 105 bacteria. While 80% of non-vaccinated ewes aborted after challenge, none of the vaccinated ewes aborted post-challenge. This study indicated that a reduced dose of Rev. 1 vaccine containing 106 or 5 × 105 live cells could be safely used to induce protection in Iranian fat-tailed sheep at various stages of pregnancy.

  12. Backscatter B [USGS]--Offshore of Santa Barbara, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of SIM 3281 presents data for part of the acoustic-backscatter map (see sheet 3, SIM 3281) of the Offshore of Santa Barbara map area, California. The...

  13. Bathymetry and Acoustic Backscatter: Northern Santa Barbara Channel, Southern California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This report presents bathymetry and acoustic backscatter data collected in July 2008 in the northern Santa Barbara Channel, California, using a bathymetric sidescan...

  14. Geology and geomorphology--Offshore Santa Cruz, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the geologic and geomorphic map of the Offshore Santa Cruz map area, California. The vector data file is included in...

  15. Backscatter B [USGS]--Offshore of Santa Barbara, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of SIM 3281 presents data for part of the acoustic-backscatter map (see sheet 3, SIM 3281) of the Offshore of Santa Barbara map area, California. The...

  16. Backscatter A [CSUMB]--Offshore of Santa Barbara, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of SIM 3281 presents data for part of the acoustic-backscatter map (see sheet 3, SIM 3281) of the Offshore of Santa Barbara map area, California. The...

  17. Seafloor character--Offshore of Santa Barbara, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of SIM 3281 presents data for the seafloor-character map (see sheet 5, SIM 3281) of the Offshore of Santa Barbara map area, California. The raster data...

  18. Geology and geomorphology--Offshore of Santa Barbara, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of SIM 3281 presents data for the geologic and geomorphic map (see sheet 10, SIM 3281) of the Offshore of Santa Barbara map area, California. The vector...

  19. Backscatter A [CSUMB]--Offshore of Santa Barbara, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of SIM 3281 presents data for part of the acoustic-backscatter map (see sheet 3, SIM 3281) of the Offshore of Santa Barbara map area, California. The...

  20. Santa Barbara, California Tsunami Forecast Grids for MOST Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Santa Barbara, California Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST)...

  1. Santa Monica, California Tsunami Forecast Grids for MOST Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Santa Monica, California Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST)...

  2. Bathymetry and Acoustic Backscatter: Northern Santa Barbara Channel, Southern California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This report presents bathymetry and acoustic backscatter data collected in July 2008 in the northern Santa Barbara Channel, California, using a bathymetric sidescan...

  3. Geology and geomorphology--Offshore Santa Cruz, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents data for the geologic and geomorphic map of the Offshore Santa Cruz map area, California. The vector data file is included in...

  4. The Trail Inventory of Santa Ana NWR [Cycle 2

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of this report is to create a baseline inventory of all non-motorized trails on Santa Ana National Wildlife Refuge. Trails in this inventory are eligible...

  5. Estuarine ecology : A report on Santa Clara County Wetlands

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report on the Santa Clara County wetlands was written just prior to the establishment of the San Francisco Bay National Wildlife Refuge. The report summarizes...

  6. Geology and geomorphology--Offshore of Santa Barbara, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of SIM 3281 presents data for the geologic and geomorphic map (see sheet 10, SIM 3281) of the Offshore of Santa Barbara map area, California. The vector...

  7. Seafloor character--Offshore of Santa Barbara, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of SIM 3281 presents data for the seafloor-character map (see sheet 5, SIM 3281) of the Offshore of Santa Barbara map area, California. The raster data...

  8. SANTA CRUZ, GUANACASTE: LOCAL CULTURE, TOURISM AND GLOBALIZATION

    OpenAIRE

    2013-01-01

    The article analyzes the relationship between local culture of the canton of Santa Cruz, Guanacaste, and the development of tourism in the canton. In a first section explores the origin and development of popular culture in the canton, linking it to traditional farming activities, and then describes the deployment of tourism in Santa Cruz, in order to analyze the popular culture of the canton in a framework of productive activities ranging from farming to tourism, in a context of econo...

  9. Evaluation of the physiological variables in Santa Inês sheep influence by the Piauí semi-arid environment

    Directory of Open Access Journals (Sweden)

    Ângela Lopes da Silva

    2015-04-01

    Full Text Available In this study we aimed to evaluate the physiological variables of sheep under the influence of Piauí semiarid environment. We used ten Santa Ines rams with black coat. The study was conducted at the small ruminants sector of the Federal University of Piauí, Campus Professora Cinobelina Elvas. Respiratory and cardiac frequencies, rectal temperature and sweating rate were measured.  Temperature, air relative humidity and globe temperature and humidity index were recorded at the Campus weather station. There was a significant difference for all the meteorological variables so that the highest values were observed for the afternoon shift, except for air relative humidity (33.52%. For physiological variables significant effect was observed for respiratory and cardiac frequencies and higher values of these variables were found in the morning shift, with 49,50 breath/min and 89,52 beats/min, respectively. For rectal temperature, significant effect was observed, with the highest values for the afternoon shift (39,92°C. We can notice that the animals needed to activate their physiological variables to keep their bodies in thermoneutral zone.

  10. Evaluation of a Salmonella Enteritidis vaccine and related ELISA for respective induction and assessment of acquired immunity to the vaccine and/or Echinacea purpurea in Awassi Ewes.

    Science.gov (United States)

    Barbour, Elie K; Assi, Chibli A Abou; Shaib, Houssam; Hamadeh, Shadi; Murtada, Muhammad; Mahmoud, Ghassan; Yaghmoor, Soonham; Iyer, Archana; Harakeh, Steve; Kumosani, Taha

    2015-05-05

    The aim of this study was to evaluate an experimental Salmonella Enteritidis (SE) bacterin and an indirect ELISA system to assess quantitatively the acquired immunity in Awassi ewes to the vaccine and/or Echinacea purpurea (EP) dried roots. Four treatments of the ewes were included in the experimental design, with 6 ewes/treatment. The first treatment (T1) had the controls that were non-vaccinated and non-treated with EP. The T2 ewes were only treated with EP. The T3 and T4 ewes were vaccinated at D1 (initiation of trial) and D10, while the T4 ewes were additionally administered the EP dried roots. Blood was collected from the jugular vein of all ewes at D1, D10, D21 and D45. The construction of the vaccine and the ELISA are detailed within the manuscript. The ELISA was able to detect quantitatively the significant acquired primary and secondary immunity to the vaccine in T3 and T4 ewes, compared to their low level of background immunities at initiation of the experiment (p0.05) in T1 control ewes, and in the T2 ewes that were given only the (EP) (p>0.05). Moreover, the ELISA was able to uncover the significant seroconversion of secondary immune response in T4 ewes at D21 compared to that at D10 (p<0.05), and the absence of significant seroconversion of secondary response in T3 ewes. This is the first work in literature that reports the need to supplement the vaccination by the experimental SE bacterin with daily oral intake of 250mg of EP-dried roots, effective the first vaccination day and up to 21 days, for obtaining a statistically significant seroconversion.

  11. Study of Blood Metabolites Changes of Purebred Ghezel and Crossbred Arkhar Merinos × Ghezel Ewes during Late Pregnancy

    Directory of Open Access Journals (Sweden)

    Leila Ahmadzadeh

    2016-11-01

    Full Text Available Introduction As pregnancy progresses, nutrient requirements of fetus and thereby ewe increases and some changes in the levels of blood metabolites including glucose, cholesterol and total protein may occur. During gestation, maternal tissues contribute to supplying energy that required for fetus resulting in changes of ewe blood metabolites; however other factors such as breed, age, feeding type of ewes during gestation and season may influence them. The study of blood metabolic changes in different phases of reproductive cycle can be helpful in detecting abnormal situations of ewes and preventing of metabolic disorders such as pregnancy toxemia and fatty liver syndrome. There is little information about the effect of different genotypes on blood metabolites and the occurrence of metabolic disorders in late pregnancy. Therefore the aim of the present study was to determine changes in blood metabolites of purebred Ghezel and ArkharMerino× Ghezel crossbred ewes during late pregnancy and effect of crossbreeding of Iranian purebred sheep with Merino sheep on metabolite level changes in these two groups of sheep and study of susceptibility to metabolic disease in late pregnancy. Materials and Methods In the present study, fifty five pregnant Ghezel ewes (36 singles and 15 twins and 34 pregnant crossbred ewes (20 singles and 14 twins were used. Estrus synchronization of all ewes was done using CIDR. CIDR were removed 14 days later and all ewes were injected PMSG intramuscularly and then mated with rams. All of the ewes were grazing in the pasture during pregnancy, but in the last two months of pregnancy, feeding of ewes was manually. Blood samples were collected by vacuum tubes during four hours after feeding from the jugular vein of ewes on 15 days prior to mating period and on days 90, 120 and 140 of the pregnancy. Blood samples were centrifuged with 4000 rpm for 12 minutes to extract blood serum and then sera were frozen in -20oC until further

  12. Nutrient contributions to the Santa Barbara Channel, California, from the ephemeral Santa Clara River

    Science.gov (United States)

    Warrick, J.A.; Washburn, L.; Brzezinski, Mark A.; Siegel, D.A.

    2005-01-01

    The Santa Clara River delivers nutrient rich runoff to the eastern Santa Barbara Channel during brief (???1-3 day) episodic events. Using both river and oceanographic measurements, we evaluate river loading and dispersal of dissolved macronutrients (silicate, inorganic N and P) and comment on the biological implications of these nutrient contributions. Both river and ocean observations suggest that river nutrient concentrations are inversely related to river flow rates. Land use is suggested to influence these concentrations, since runoff from a subwatershed with substantial agriculture and urban areas had much higher nitrate than runoff from a wooded subwatershed. During runoff events, river nutrients were observed to conservatively mix into the buoyant, surface plume immediately seaward of the Santa Clara River mouth. Dispersal of these river nutrients extended 10s of km into the channel. Growth of phytoplankton and nutrient uptake was low during our observations (1-3 days following runoff), presumably due to the very low light levels resulting from high turbidity. However, nutrient quality of runoff (Si:N:P = 16:5:1) was found to be significantly different than upwelling inputs (13:10:1), which may influence different algal responses once sediments settle. Evaluation of total river nitrate loads suggests that most of the annual river nutrient fluxes to the ocean occur during the brief winter flooding events. Wet winters (such as El Nin??o) contribute nutrients at rates approximately an order-of-magnitude greater than "average" winters. Although total river nitrate delivery is considerably less than that supplied by upwelling, the timing and location of these types of events are very different, with river discharge (upwelling) occurring predominantly in the winter (summer) and in the eastern (western) channel. ?? 2004 Elsevier Ltd. All rights reserved.

  13. STAT3 Regulates Proliferation and Immunogenicity of the Ewing Family of Tumors In Vitro

    Directory of Open Access Journals (Sweden)

    Sam Behjati

    2012-01-01

    Full Text Available The Ewing sarcoma family of tumors (ESFT represents an aggressive spectrum of malignant tumour types with common defining histological and cytogenetic features. To evaluate the functional activation of signal transducer and activator of transcription 3 (STAT3 in ESFT, we evaluated its activation in primary tissue sections and observed the functional consequences of its inhibition in ESFT cell lines. STAT3 was activated (tyrosine 705-phosphorylated in 18 out of 31 primary tumours (58%, either diffusely (35% or focally (23%. STAT3 was constitutively activated in 3 out of 3 ESFT cell lines tested, and its specific chemical inhibition resulted in complete loss of cell viability. STAT3 inhibition in ESFT cell lines was associated with several consistent changes in chemokine profile suggesting a role of STAT3 in ESFT in both cell survival and modification of the cellular immune environment. Together these data support the investigation of STAT3 inhibitors for the Ewing family of tumors.

  14. Effect of autochthonous starter cultures on the biogenic amine content of ewe's milk cheese throughout ripening.

    Science.gov (United States)

    Renes, E; Diezhandino, I; Fernández, D; Ferrazza, R E; Tornadijo, M E; Fresno, J M

    2014-12-01

    Cheese is among the most commonly implicated foods associated with biogenic amines poisoning. The aim of this study was to evaluate the effects of the type of autochthonous starter culture and ripening time on the concentration of biogenic amines (histamine, tyramine, putrescine, cadaverine, tryptamine, β-phenylethylamine, spermine and spermidine) in cheeses made from pasteurized ewe's milk. 4 cheese batches were made, in duplicate, and ripened for 7 months. The biogenic amines of 40 cheeses were analysed by high performance liquid chromatography. The predominant biogenic amines determined at the end of the ripening time were phenylethylamine, spermine and tryptamine. Together, these accounted for 81% of the total of biogenic amines studied. The type of starter culture used to make the ewe's cheese had a significant effect (p culture made up entirely of Lactococcus lactis subsp. lactis and L. lactis subsp. cremoris or of the same in combination with Lactobacillus plantarum.

  15. Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Kidney: A Rare and Lethal Entity.

    Science.gov (United States)

    Celli, Romulo; Cai, Guoping

    2016-03-01

    Ewing sarcoma/primitive neuroectodermal tumor represents a spectrum of undifferentiated tumors with similar biology that together represent the second most common sarcoma in the pediatric-young adult age range. Very rarely, this tumor presents as a primary neoplasm of the kidney. The clinical presentation of this tumor is not specific, and other renal tumors may present with a similar histologic appearance. Establishing the correct diagnosis is critical because renal Ewing sarcoma/primitive neuroectodermal tumor carries a strikingly dismal prognosis and thus dictates a specific treatment strategy. A low threshold for the use of ancillary molecular tests is recommended, particularly in diagnostically problematic cases. Important considerations with regards to morphology, immunohistochemistry, and molecular alterations will be reviewed here and should be taken into account before rendering this rare and lethal diagnosis.

  16. The effects of anthelmintic treatments against gastrointestinal nematodes on the performance of breeding ewes and lambs on pasture in semi-arid Kenya.

    Science.gov (United States)

    Ng'ang'a, C J; Maingi, N; Kanyari, P W N; Munyua, W K

    2009-08-01

    The effects of anthelmintics treatments in controlling gastrointestinal nematodes in breeding ewes in a semi-arid area of Kenya were determined. The study carried out during two breeding seasons, between June 2000 and December 2001 where albendazole was administered to groups of ewes, 2 weeks before mating, 3 weeks to lambing and mid lactation indicated significantly lower nematode egg counts in treated than untreated groups of ewes. In the first breeding season, reduced rainfall resulted in pasture scarcity and weight loss in both groups of ewes through out the gestation period, but losses were higher for the untreated group. In the second season, both groups of ewes showed a steady increase in weight gain during the gestation period and post-partum, but weight gains were higher in the treated group. In lambs, weight gains at 6 weeks were higher for treated ewes than control groups, in both breeding seasons. The results of this trial indicate that anthelmintic treatments in breeding ewes in the study area are beneficial in reducing gastrointestinal nematode infections and improving performance of the ewes and their lambs. In addition to the treatments, breeding ewes should be given feed supplementation particularly during periods of pasture scarcity.

  17. A pre-partum lift in ewe nutrition from a high-energy lick or maize or by grazing Lotus uliginosus pasture, increases colostrum production and lamb survival.

    Science.gov (United States)

    Banchero, G E; Quintans, G; Lindsay, D R; Milton, J T B

    2009-08-01

    This experiment tested the hypothesis that a lift in the nutrition of ewes, before lambing, to increase colostrum production would enhance lamb survival. In all, 261 mature Corriedale ewes, each with a single fetus from a synchronised mating, grazed native pasture to day 130 after mating; at which point they were weighed, condition scored and allocated to graze either native pasture or a pasture dominant with Lotus uliginosus. Five days later (14 days before the expected start of lambing) the ewes were allocated to one of four treatments and fed: (i) native pasture alone, (ii) native pasture plus a commercial high-energy lick, (iii) L. uliginosus pasture alone or (iv) L. uliginosus pasture plus whole maize. The weight, viscosity and concentration of components and immunoglobulin G in the colostrum that had accumulated at parturition, were measured for 10 ewes in each treatment. The lambs that survived to 20 days of age from the 221 ewes that were not milked, were recorded. The ewes supplemented with the lick or maize grain and those that grazed the L. uliginosus pasture alone accumulated two to three times more colostrum at birth than the ewes that grazed native pasture alone (396, 635 and 662 g v. 206 g; P < 0.01). The colostrum from the ewes that grazed only native pasture was more viscous (lower score) than that from the ewes supplemented with the lick or maize grain or the ewes that grazed the L. uliginosus pasture alone (scores of 4.1 v. 6.2, 6.5 and 6.4, P < 0.001) and, not surprisingly, the concentration of lactose in the colostrum of the ewes fed only native pasture was also much lower (1.1% v. 3.0%, 2.8% and 2.6%; P < 0.001)he survival of lambs from the ewes fed only native pasture was less than that of the lambs from ewes fed native pasture plus the commercial lick (81.8% v. 95.5%; P < 0.05) or the L. uliginosus pasture alone (92.4%, P < 0.05), and also tended to be lower than that for lambs born to ewes fed L. uliginosus pasture plus maize (91.8%, P = 0

  18. Effect of dietary restriction, pregnancy, and fetal type on intestinal cellularity and vascularity in Columbia and Romanov ewes.

    Science.gov (United States)

    Scheaffer, A N; Caton, J S; Redmer, D A; Arnold, D R; Reynolds, L P

    2004-10-01

    The objectives of this study were to evaluate intestinal cellularity and vascularity in mature ewes in response to dietary restriction and pregnancy status and to quantify the response of these variables to increased nutrient demand of fetal growth. In Exp. 1, 28 mature Dorset x crossbred white-faced ewes (61.6+/-1.8 kg initial BW) were fed a pelleted, forage-based diet. Treatments were arranged in a 2 x 3 factorial, with dietary restriction (60% restriction vs. 100% maintenance for respective states of pregnancy) and pregnancy status (nonpregnant, NP; d 90 and 130) as main effects. Dietary treatments were initiated on d 50 of gestation and remained at 60 or 100% maintenance throughout the experiment. Nonpregnant ewes were fed dietary treatments for 40 d. In Exp. 2, four Romanov ewes were naturally serviced (Romanov fetus and Romanov dam; R/R); two Romanov embryos per recipient were transferred to four Columbia recipients (Romanov fetus and Columbia recipient; R/C), and three Columbia ewes were naturally serviced (Columbia fetus and Columbia dam; C/C). In Exp. 1, dietary restriction and pregnancy status interacted with regard to maternal jejunal DNA concentration (P < 0.01), with restricted ewes having a greater DNA concentration (mg/g; fresh basis) at d 130. Vascularity (percentage of total tissue area) in the jejunum was increased (P < 0.06) as a result of dietary restriction and pregnancy status. Total microvascular volume ofjejunal tissue was not altered by dietary restriction and increased (P < 0.01) at d 130 of pregnancy. In Exp. 2, R/R ewes had less (P < 0.09) DNA (g) in the jejunum compared with R/C and C/C ewes. Jejunal vascularity (%) was increased (P < 0.05) in R/R ewes compared with R/C or C/C ewes, whereas total jejunal microvascular volume remained unchanged. These data demonstrate intestinal vascular density responds to changes in diet and physiological state. In addition, pregnancy increased total jejunal microvascular volume.

  19. Pathogenicity and Immunogenicity of a Mutagen-Attenuated Rift Valley Fever Virus Immunogen in Pregnant Ewes

    Science.gov (United States)

    1987-07-01

    RVFV antibody titers of < 1:10 at birth, increasing to > animals to produce attenuated virus vaccines."’ Prop- 1:80 after ingestion of colostrum ...immunogenicity of the mutagenized ZH- Culex pipiens that fed on the MV P12-inoculated ewes 548 strain RVFV (MV P12) in pregnant sheep and to as- failed to...reduction neutralization assay. viral disease of sheep , cattle, and goats.’ 2 Infected ani- mals develop high viremia titers, virtually all pregnant

  20. A Decade in Banking Ewing Sarcoma: A Report from the Children's Oncology Group.

    Science.gov (United States)

    Borinstein, Scott C; Beeler, Natalie; Block, John J; Gorlick, Richard; Grohar, Patrick; Jedlicka, Paul; Krailo, Mark; Morris, Carol; Phillips, Sharon; Siegal, Gene P; Lawlor, Elizabeth R; Lessnick, Stephen L

    2013-01-01

    Outcomes for patients with metastatic and recurrent Ewing sarcoma remain poor and a better understanding of the biology of this malignancy is critical to the development of prognostic biomarkers and novel therapies. Therefore, the Children's Oncology Group (COG) has created tissue banking protocols designed to collect high quality, clinically annotated, tumor specimens that can be distributed to researchers to perform basic science and correlative investigation. Data from the COG Ewing sarcoma tissue banking protocols AEWS02B1 and its successor study AEWS07B1 were reviewed in this study. Six-hundred and thirty five patients were enrolled on AEWS02B1 and 396 patients have had tissue submitted to AEWS07B1. The average age of participation was 13.2 years. About 86% were less than 19 years old and only 6% were greater than 21 years of age at diagnosis. When compared to SEER data, approximately 18% of all cases and only 8% of all patients >20 years old diagnosed with Ewing sarcoma annually in the United States have had tumor banked. The majority of participants submitted formalin fixed, paraffin embedded, primary tumor and blood samples. In total, fresh frozen tissue was submitted for only 29% of cases. Only seven metastatic tumor samples have been collected. Although the COG has been successful in collecting tumor samples from patients newly diagnosed with Ewing sarcoma, fresh frozen tumor specimens from primary and metastatic disease are critically needed, especially from young adult patients, in order to conduct high quality basic science and translational research investigation with a goal of developing better treatments.

  1. A Decade in Banking Ewing Sarcoma: A Report from the Children’s Oncology Group

    Science.gov (United States)

    Borinstein, Scott C.; Beeler, Natalie; Block, John J.; Gorlick, Richard; Grohar, Patrick; Jedlicka, Paul; Krailo, Mark; Morris, Carol; Phillips, Sharon; Siegal, Gene P.; Lawlor, Elizabeth R.; Lessnick, Stephen L.

    2013-01-01

    Outcomes for patients with metastatic and recurrent Ewing sarcoma remain poor and a better understanding of the biology of this malignancy is critical to the development of prognostic biomarkers and novel therapies. Therefore, the Children’s Oncology Group (COG) has created tissue banking protocols designed to collect high quality, clinically annotated, tumor specimens that can be distributed to researchers to perform basic science and correlative investigation. Data from the COG Ewing sarcoma tissue banking protocols AEWS02B1 and its successor study AEWS07B1 were reviewed in this study. Six-hundred and thirty five patients were enrolled on AEWS02B1 and 396 patients have had tissue submitted to AEWS07B1. The average age of participation was 13.2 years. About 86% were less than 19 years old and only 6% were greater than 21 years of age at diagnosis. When compared to SEER data, approximately 18% of all cases and only 8% of all patients >20 years old diagnosed with Ewing sarcoma annually in the United States have had tumor banked. The majority of participants submitted formalin fixed, paraffin embedded, primary tumor and blood samples. In total, fresh frozen tissue was submitted for only 29% of cases. Only seven metastatic tumor samples have been collected. Although the COG has been successful in collecting tumor samples from patients newly diagnosed with Ewing sarcoma, fresh frozen tumor specimens from primary and metastatic disease are critically needed, especially from young adult patients, in order to conduct high quality basic science and translational research investigation with a goal of developing better treatments. PMID:23519678

  2. Bacterial species and their associations with acute and chronic mastitis in suckler ewes.

    Science.gov (United States)

    Smith, E M; Willis, Z N; Blakeley, M; Lovatt, F; Purdy, K J; Green, L E

    2015-10-01

    Acute mastitis in suckler ewes is often detected because of systemic signs such as anorexia or lameness, whereas chronic mastitis, characterized by intramammary abscesses with no systemic disease, is typically detected when ewes are inspected before mating. The aims of the current study were to identify the species and strains of culturable bacteria associated with acutely diseased, chronically diseased, and unaffected mammary glands to investigate whether species and strains vary by state. To investigate acute mastitis, 28 milk samples were obtained from both glands of 14 ewes with acute mastitis in one gland only. To investigate chronic mastitis, 16 ovine udders were obtained from 2 abattoirs; milk was aspirated from the 32 glands where possible, and the udders were sectioned to expose intramammary abscesses, which were swab sampled. All milk and swab samples were cultured aerobically. In total, 37 bacterial species were identified, 4 from acute mastitis, 26 from chronic mastitis, and 8 from apparently healthy glands. In chronic mastitis, the overall coincidence index of overlap of species detected in intramammary abscesses and milk was 0.60, reducing to 0.36 within individual glands, indicating a high degree of species overlap in milk and abscesses overall, but less overlap within specific glands. Staphylococcus aureus was detected frequently in all sample types; it was isolated from 10/14 glands with acute mastitis. In 5 ewes, closely related strains were present in both affected and unaffected glands. In chronic mastitis, closely related Staphylococcus aureus strains were detected in milk and abscesses from the same gland. Copyright © 2015 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  3. Cytopathological findings of primary pulmonary Ewing family of tumors with EWSR1 translocation: A case report

    OpenAIRE

    Mizuguchi, Keishi; Minato, Hiroshi; Onishi, Hitomi; Mitani, Yuki; Kawai, Jun

    2016-01-01

    Primary pulmonary neoplasms of the Ewing family of tumors (EFT) are extremely rare and usually occur in adolescents or young adults. Only about 40 cases of pulmonary EFT have been reported in English literature, and no cytological studies have been documented. In this report, we describe the cytopathological findings of a primary pulmonary EFT in an elderly patient. A 70‐year‐old man sought care because of a progressing cough and dyspnea. Chest computed tomography revealed a circumscribed mas...

  4. Transcript profiling in the milk of dairy ewes fed extruded linseed

    OpenAIRE

    Giordani, Tommaso; Vangelisti, Alberto; Conte, Giuseppe; SERRA, ANDREA; Natali, Lucia; Ranieri, Annamaria; Mele, Marcello; Cavallini, Andrea

    2016-01-01

    The identification of genes regulating milk secretion by mammary glands is a key-step for exploiting changes in milk composition induced by different diet regimens. Linseed supplementation is a reliable feeding strategy to enhance polyunsaturated fatty acid content in milk fat from sheep, increasing milk quality and nutraceutical value. To investigate the molecular bases of diet induced differences in milk composition, we collected milk from dairy ewes at 90 day of lactation and after 3 weeks...

  5. A field study of reproductive performance and productivity of Pelibuey ewes in Southeastern Mexico.

    Science.gov (United States)

    Magaña-Monforte, Juan Gabriel; Huchin-Cab, Miguel; Ake-López, Ricardo Jesus; Segura-Correa, Jose Candelario

    2013-11-01

    The objective was to evaluate the reproductive performance and productivity of Pelibuey ewes in two flocks in Southeastern Mexico. Animals grazed on irrigated star grass (Cynodon plectostachyus). In flock 1, lambs grazed with their mothers from 7 to 70 days of age (weaning age), whereas in flock 2, they were confined and offered chopped grass, a commercial concentrated and managed under restricted suckling until weaning at 60 days of age.. The statistical model included the fixed effects of flock, year and season of lambing, parity number, litter size at weaning, first order interactions and the random effects of ewe and the error term. The means ± SD for age at first lambing, prolificacy, lambing interval (LI), weaning weight, and productivity were 477 ± 85.5 days, 1.41 ± 0.51 lambs, 255.9 ± 51.8 days, 16.5 ± 4 kg, and 18.1 ± 4.42 kg of lamb weaned, respectively. Repeatability estimates for the latter four traits were 0.09, 0.07, 0.11, and 0.13, respectively. All main effects in the models were significant (P season. Ewes with two or three lambs produced 8 and 14 kg of lamb more at weaning than single lamb ewes. In conclusion, reproductive performance and productivity could be improved, and the low repeatability estimates suggest that management should be used in a short term rather than genetic approaches.

  6. Santa Barbara Cluster Comparison Test with DISPH

    Science.gov (United States)

    Saitoh, Takayuki R.; Makino, Junichiro

    2016-06-01

    The Santa Barbara cluster comparison project revealed that there is a systematic difference between entropy profiles of clusters of galaxies obtained by Eulerian mesh and Lagrangian smoothed particle hydrodynamics (SPH) codes: mesh codes gave a core with a constant entropy, whereas SPH codes did not. One possible reason for this difference is that mesh codes are not Galilean invariant. Another possible reason is the problem of the SPH method, which might give too much “protection” to cold clumps because of the unphysical surface tension induced at contact discontinuities. In this paper, we apply the density-independent formulation of SPH (DISPH), which can handle contact discontinuities accurately, to simulations of a cluster of galaxies and compare the results with those with the standard SPH. We obtained the entropy core when we adopt DISPH. The size of the core is, however, significantly smaller than those obtained with mesh simulations and is comparable to those obtained with quasi-Lagrangian schemes such as “moving mesh” and “mesh free” schemes. We conclude that both the standard SPH without artificial conductivity and Eulerian mesh codes have serious problems even with such an idealized simulation, while DISPH, SPH with artificial conductivity, and quasi-Lagrangian schemes have sufficient capability to deal with it.

  7. Santa Claus Schedules Jobs on Unrelated Machines

    CERN Document Server

    Svensson, Ola

    2010-01-01

    One of the classic results in scheduling theory is the 2-approximation algorithm by Lenstra, Shmoys, and Tardos for the problem of scheduling jobs to minimize makespan on unrelated machines, i.e., job j requires time p_{ij} if processed on machine i. More than two decades after its introduction it is still the algorithm of choice even in the restricted model where processing times are of the form p_{ij} in {p_j, \\infty}. This problem, also known as the restricted assignment problem, is NP-hard to approximate within a factor less than 1.5 which is also the best known lower bound for the general version. Our main result is a polynomial time algorithm that estimates the optimal makespan of the restricted assignment problem within a factor 33/17 + \\epsilon \\approx 1.9412 + \\epsilon, where \\epsilon > 0 is an arbitrary small constant. The result is obtained by upper bounding the integrality gap of a certain strong linear program, known as configuration LP, that was previously successfully used for the related Santa...

  8. Correlation of Ezrin Expression Pattern and Clinical Outcomes in Ewing Sarcoma

    Directory of Open Access Journals (Sweden)

    Thomas Cash

    2017-01-01

    Full Text Available Background. Ezrin is a membrane-cytoskeleton linker protein that has been associated with metastasis and poor outcomes in osteosarcoma and high-grade soft tissue sarcomas. The prognostic value of ezrin expression in Ewing sarcoma is unknown. Methods. The relationship between ezrin expression and outcome was analyzed in a cohort of 53 newly diagnosed Ewing sarcoma patients treated between 2000 and 2011. The intensity and proportion of cells with ezrin immunoreactivity were assessed in diagnostic tumor tissue using a semiquantitative scoring system to yield intensity and positivity scores for each tumor. Results. Ezrin expression was detected in 72% (38/53 of tumor samples. The proportion of patients with metastatic disease was equal in the positive and negative ezrin expression groups. There was no significant difference in the 5-year event-free survival (EFS between patients with positive versus negative ezrin expression. Patients whose tumor sample showed high ezrin intensity had significantly better 5-year EFS when compared to patients with low/no ezrin intensity (78% versus 55%; P=0.03. Conclusions. Ezrin expression can be detected in the majority of Ewing sarcoma tumor samples. Intense ezrin expression may be correlated with a favorable outcome; however further investigation with a larger cohort is needed to validate this finding.

  9. Factors Affecting Milk Yield, Composition and Udder Health of Najdi Ewes

    Directory of Open Access Journals (Sweden)

    M. Ayadi

    2014-02-01

    Full Text Available Although Najdi milk has been historically utilized by bedouins to process traditional dairy products, no published studies have been focused on their milk productivity and quality traits. This study was planned to investigate the effects of litter size, sex of lamb and lamb’s birth weight on milk yield, compositions and udder health during suckling and milking periods. A total of 30 multiparous ewes were utilized in this study. Litter size and sex of lambs did not produce any effects (p>0.05 on milk yield, fat, protein, lactose, total solids and Somatic Cell Counts (SCC; whereas, lamb’s birth weight significantly (p0.05 to attain 1.88±0.18 L in the 9th week of lactation. Average milk yield were 2.17 and 1.71 L.d-1, for ewes that gave birth to lambs weighing >5 and 0.05 and had a mean value of 9.95×105 cells/mL. It is concluded that the indigenous Najdi ewes have a noticeable potential for milk production, but milk compositions were lower in comparison to other international dairy sheep.

  10. Ewing sarcoma cells secrete EWS/Fli-1 fusion mRNA via microvesicles.

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    Masanori Tsugita

    Full Text Available Tumours defined as Ewing sarcoma (ES constitute a group of highly malignant neoplasms that most often affect children and young adults in the first 2 decades of life. The EWS/Fli-1 fusion gene, a product of the translocation t(11;22 (q24; 12, is detected in 95% of ES patients. Recently, it was validated that cells emit a heterogeneous mixture of vesicular, organelle-like structures (microvesicles, MVs into their surroundings including blood and body fluids, and that these MVs contain a selected set of tumor-related proteins and high levels of mRNAs and miRNAs. In this present study, we detected the Ewing sarcoma-specific EWS/Fli-1 mRNA in MVs from the culture medium of ES cell lines carrying t(11;22 (q24; 12. Also, we detected this fusion gene in approximately 40% of the blood samples from mice inoculated with xenografts of TC135 or A673 cells. These findings indicate the EWS/Fli-1 mRNA in MVs might be a new non-invasive diagnostic marker for specific cases of Ewing sarcoma.

  11. Prediction of fatty acid profiles in cow, ewe, and goat milk by mid-infrared spectrometry.

    Science.gov (United States)

    Ferrand-Calmels, M; Palhière, I; Brochard, M; Leray, O; Astruc, J M; Aurel, M R; Barbey, S; Bouvier, F; Brunschwig, P; Caillat, H; Douguet, M; Faucon-Lahalle, F; Gelé, M; Thomas, G; Trommenschlager, J M; Larroque, H

    2014-01-01

    Mid-infrared (MIR) spectrometry was used to estimate the fatty acid (FA) composition in cow, ewe, and goat milk. The objectives were to compare different statistical approaches with wavelength selection to predict the milk FA composition from MIR spectra, and to develop equations for FA in cow, goat, and ewe milk. In total, a set of 349 cow milk samples, 200 ewe milk samples, and 332 goat milk samples were both analyzed by MIR and by gas chromatography, the reference method. A broad FA variability was ensured by using milk from different breeds and feeding systems. The methods studied were partial least squares regression (PLS), first-derivative pretreatment + PLS, genetic algorithm + PLS, wavelets + PLS, least absolute shrinkage and selection operator method (LASSO), and elastic net. The best results were obtained with PLS, genetic algorithm + PLS and first derivative + PLS. The residual standard deviation and the coefficient of determination in external validation were used to characterize the equations and to retain the best for each FA in each species. In all cases, the predictions were of better quality for FA found at medium to high concentrations (i.e., for saturated FA and some monounsaturated FA with a coefficient of determination in external validation >0.90). The conversion of the FA expressed in grams per 100mL of milk to grams per 100g of FA was possible with a small loss of accuracy for some FA.

  12. Responses of Early Lactating Ewes to Cold Stress Exposure Preliminary Results

    Directory of Open Access Journals (Sweden)

    Dinu Gavojdian

    2012-10-01

    Full Text Available The aim of this study was to measure cold stress of ewes during post lambing period. The trial was undertaken at theExperimental Farm of Banat’s University of Agricultural Sciences and Veterinary Medicine Timisoara, duringFebruary 2012. Six secundiparous Turcana breed ewes were housed in two collective pens of 3.5 m x 2 m each, withdeep straw bedding, in shed where the average temperature was of -1.2°C. Cortisol levels from milk samples weredetermined as indicators of cold stress. Samples were collected at 14 hours after lambing, and at 7, 14 and 21 daysfollowing parturition. At 14 hours after lambing, mean cortisol levels were 7.78±0.47 μg/dl, and decreased asfollows: 5.08±0.72 μg/dl in the 7th of the trial, 2.75±0.50 μg/dl in day 14 and 1.61±0.43 μg/dl in day 21 of theobservations. Differences were significant between the 7 day sampling intervals (p≤0.01 during the first 14 daysafter lambing, while non-significant differences (p≥0.05 have been found between the 14 and 21 days samplings. Ithas been concluded that cortisol levels in milk samples could prove an indicator of sheep adrenal-cortex activity thatmay be applied to measure cold stress in lactating ewes.

  13. The effect of angiotensin-converting enzyme inhibition throughout a superovulation protocol in ewes.

    Science.gov (United States)

    Pereira, Alécio Matos; de Souza Júnior, Antônio; Machado, Fernanda Brandão; Gonçalves, Gleisy Kelly Neves; Feitosa, Lauro César Soares; Reis, Adelina Martha; Santos, Robson Augusto Souza; Honorato-Sampaio, Kinulpe; Costa, Amilton Raposo

    2015-12-01

    Many studies identified new components of the renin–angiotensin system (RAS), such as Angiotensin-(1-7) [Ang-(1–7)] and Angiotensin-converting enzyme type 2 (ACE2), in mammalian ovaries.We previously showed Angiotensin-Converting Enzyme (ACE) inhibition, which increases the level of Ang-(1–7), stimulated ovarian estradiol output in ewe after estrous synchronization. Considering that Ang-(1–7) stimulates ovarian function and elevated estradiol before ovulation is associated with increased chance of achieving pregnancy, the present study investigated whether ACE inhibition throughout a superovulation protocol in ewe might improve ovulation outcome. At first, immunohistochemistry in ovaries of nonpregnant ewes revealed localization of Angiotensin II (Ang II), Ang-(1–7) and ACE2 in theca cells of antral follicles and in corpus luteum. Ang II and Ang-(1–7)were also detected in follicular fluid (FF) by Radioimmunoassay (RIA). Enalapril treatment throughout the superovulation protocol decreased 17β-estradiol (E2) output and raised progesterone:estradiol (P4:E2) ratio without a direct influence on ovulation and quality of embryos.

  14. Massive Pleural Effusion in an 18-Year-Old Girl with Ewing Sarcoma

    Directory of Open Access Journals (Sweden)

    Cengiz Özge

    2004-01-01

    Full Text Available Ewing sarcoma is a bone tumour that commonly appears between ages five and 10 in the diaphysis of the long bones and predominantly presents with pain and swelling. The case of an 18-year-old girl who presented with back pain, cough, dyspnea, weakness and fever is described. Chest radiograph showed a homogenous density in the middle and inferior zones of the right hemithorax. Thoracic computed tomography revealed a diffuse pleural effusion and a 6.99 cmx4.45 cm solid mass composed of lobulated, small cystic lesions and calcifications in the right hemithorax. Biochemical analysis of pleural fluid showed hemorrhagic effusion and exudate. A pleural needle biopsy demonstrated solid uniform tumour cells with narrowed cytoplasm, round nuclei and uncertain nucleoli. All of the tumour cell cytoplasms stained with CD99. The pathological examination supported Ewing sarcoma. Three-phase Tc-99m methylene diphosphonate scintigraphy of the whole body showed pathological tracer uptake in a broad area of the eighth costal bone and in smaller areas of the ninth and 10th costal bones. This case is reported because Ewing sarcoma is a rare cause of pleural effusion in clinical practice among younger adults.

  15. Fatty acid composition of ewe milk as affected by solar radiation and high ambient temperature.

    Science.gov (United States)

    Sevi, Agostino; Rotunno, Taddeo; Di Roberto, Caterina; Muscio, Antonio

    2002-05-01

    Forty lactating Comisana ewes were either exposed to or protected from solar radiation and fed either in the morning or afternoon during summer in a Mediterranean climate. Individual milk samples were taken on days 7, 21 and 42 of the study period to determine fatty acid composition by gas chromatography. Exposure to solar radiation resulted in higher proportions of short-chain and saturated fatty acids in milk, primarily because of increased contents of caproic, capric, lauric, myristic and stearic acids (by 3-18%), and decreased contents of oleic, linoleic and linolenic acids (by 2-9%). As a consequence, the long to short chain and the unsaturated to saturated fatty acid ratios were significantly higher by 4 and 13% respectively in the milk of the protected ewes compared with that of the exposed animals. Provision of shade also led to an increase in the 18:0+18:1 to 16:0 ratio, and to a decrease in the 12:0 + 14:0 + 16:0 fatty acid group, which are regarded as reliable indexes of the nutritional property of dietary fat in reducing cholesterol levels in human plasma. Feeding time had little impact on milk fat. Our findings suggest that high ambient temperature may markedly modify the lipid composition of ewe milk and that provision of shade, but not feeding management, can improve the milk fatty acid profile in dairy sheep raised in hot climates.

  16. Increase of energy balance significantly alters major lipogenic gene expression in lactation ewes.

    Science.gov (United States)

    Laliotis, George P; Bizelis, Iosif; Vitsa, Alkistis; Rogdakis, Emmanuel

    2012-01-01

    The objective of the present study was to examine changes observed in the expression of cytosolic NADP isocitrate dehydrogenase (ICDH) and glucose 6-phosphate dehydrogenase (G6PD) genes, the major implicated genes in ruminant lipogenesis in terms of produce NADPH, during the early post-weaning period in dairy ewes in respect to energy intake, and to further correlate the noted changes with their respective enzymatic activities. A total of 21 subcutaneous adipose tissue samples were obtained from seven lactating (2nd lactation period) dairy ewes of the Chios breed. Adipose tissue samples were taken from the tail head region at weeks 1, 2, and 4 after weaning (45 days after parturition). Dairy ewes were in negative energy balance during weeks 1 and 2 after weaning and they moved into a strong positive energy balance at week 4 after weaning. Expression of ICDH and G6PD genes and their respective enzymatic activity was determined. Results showed that both genes' expression and enzymatic activities were significantly minimal at week 1 after weaning, reaching a maximum level at week 4 after weaning (P gene expression (P energy intake changes. Almost similar changes were observed for enzymatic activities, rendering these enzymes as potential biochemical markers of ovine lipogenesis. Copyright © Taylor & Francis Group, LLC

  17. Identification of immunologically relevant proteins of Chlamydophila abortus using sera from experimentally infected pregnant ewes.

    Science.gov (United States)

    Marques, P X; Souda, Puneet; O'Donovan, J; Gutierrez, J; Gutierrez, E J; Worrall, S; McElroy, M; Proctor, A; Brady, C; Sammin, D; Basset, H F; Whitelegge, Julian P; Markey, B E; Nally, J E

    2010-08-01

    Chlamydophila abortus is an intracellular pathogen and the etiological agent of enzootic abortion of ewes (EAE). C. abortus has a biphasic development cycle; extracellular infectious elementary bodies (EB) attach and penetrate host cells, where they give rise to intracellular, metabolically active reticulate bodies (RB). RB divide by binary fission and subsequently mature to EB, which, on rupture of infected cells, are released to infect new host cells. Pregnant ewes were challenged with 2 x 10(6) inclusion forming units (IFU) of C. abortus cultured in yolk sac (comprising both EB and RB). Serum samples were collected at 0, 7, 14, 21, 27, 30, 35, 40, and 43 days postinfection (dpi) and used to identify antigens of C. abortus expressed during disease. Additionally, sera from fetal lambs were collected at 30, 35, 40, and 43 dpi. All serum samples collected from experimentally infected pregnant ewes reacted specifically with several antigens of EB as determined by one-dimensional (1-D) and 2-D gel electrophoresis; reactive antigens identified by mass spectrometry included the major outer membrane protein (MOMP), polymorphic outer membrane protein (POMP), and macrophage infectivity potentiator (MIP) lipoprotein.

  18. Relationship Between Gastrointestinal Parasite Infection and Faecal Protein Excretion in Moghani ewes

    Directory of Open Access Journals (Sweden)

    S. Hassanpour

    2011-06-01

    Full Text Available The aim of this study was to investigate relationship between Faecal Egg Counts (FECs and protein excretion in naturally acquired nematode infected Moghani ewes. Thirty-five Moghani ewes (aged from 6 to 12 months and average of body weight 32±3 kg were selected among the naturally acquired nematode infected animals which their infection had confirmed by McMaster flotation method. The animals were divided into 5 groups according to the FECs (470. Faecal samples were taken directly from the rectum of each animal in early morning and kept in individual sampling containers under 4ºC. Faecal parameters such as Crude Protein (CP, Dry Matter (DM, Organic Matter (OM and ash were determined using the Kjeldahl method following the standard procedures. Data were processed in excel and statistical analysis was performed using SPSS/ver. 17 software. Our data indicates that there was a significant difference among groups for the faecal ash and OM values (p0.1, r = - 0.290 in the naturally acquired nematode infected Moghani ewes. In conclusion, the FECs was not a good indication for interpretation of faecal protein excretion in nematode infected sheep.

  19. Serum hormone profiles, pregnancy rates, and offspring performance of Rambouillet ewes treated with recombinant bovine somatotropin before breeding.

    Science.gov (United States)

    Camacho, L E; Benavidez, J M; Hallford, D M

    2012-08-01

    An experiment was conducted to examine effects of bovine ST (bST) on serum hormone concentrations, pregnancy rates, and offspring performance. Before initiation of a fall breeding period, 75 Rambouillet ewes (68.8 ± 1.5 kg) received an intravaginal insert containing 0.3 g of progesterone (P4) to synchronize onset of estrus. After 12 d, inserts were removed (d 0), and ewes (stratified by BW and age) received either 0 (control, n = 37) or 250 (n = 38) mg of recombinant bST (Posilac, Monsanto, St. Louis, MO, subcutaneously). Ewes were joined with fertile rams 24 h after insert removal. Blood samples were collected from 12 ewes in each treatment group daily from d 0 to 20 after insert removal. Serum IGF-I concentrations were 315 and 437 (± 58) ng/mL in control and bST-treated ewes 2 d after receiving bST (P = 0.02) and remained increased (P 0.10) and estradiol (P = 0.65) were similar between treatments. Serum triiodothyronine (T3) and thyroxine (T4) concentrations were similar (P > 0.20) between treatments from d 0 through 8. Controls had greater (P 0.10) in control and bST-treated ewes from d 0 through 3 but was increased (P 0.10) between treatments from d 9 to 20. Serum insulin concentrations were 0.44 and 1.74 (± 0.19) ng/mL in control and bST-treated ewes, respectively, 1 d after receiving bST (P Pregnancy rates and offspring adjusted weaning weights were decreased by bST treatment immediately before breeding.

  20. Feed intake and competition in ewes on ad libitum or semi-restricted feeding of grass silage and hay.

    Science.gov (United States)

    Bøe, K E; Ottosen, A M; Andersen, I L

    2012-11-01

    The aim of the present experiment was to investigate the effect of feeding level and type of roughage on feed intake, feeding behavior and competition of ewes. A 2 × 2 factorial experiment was conducted with amount of roughage available (ad libitum or semi restricted) and type of roughage (grass silage or hay) as main factors. Forty-eight ewes were randomly assigned to 8 groups of 6 ewes. All groups were subjected to all 4 treatments, each treatment period lasted 7 d, and the order of treatments was rotated systematically. The ewes were video recorded for the 2 last days of each treatment period and feeding and general activity were scored every 10 min. All aggressive interactions and displacement at the feed barrier were scored continuously the first 3 h after feeding. Daily feed intake (P less time feeding (P < 0.0001), had a greater individual variation in feeding time (P < 0.05) and spent more time queuing for feed (standing maximum 1.5 m from the feeding barrier with the head towards the feed; P < 0.0001). Individual data showed that 5 ewes fed hay and 3 ewes fed silage reduced their time spent feeding more than 50% when the feeding level was reduced. When fed hay, the level of feeding did not affect number of aggressive interactions or displacements, but when fed silage the number of aggressive interactions (P < 0.01) and the number of displacements (P < 0.05) were much greater in the semi-restricted than in the ad libitum treatment. We conclude that even a minor restriction in the level of feeding will decrease time spent feeding and increase queuing and number of aggressive interactions when feeding space is also restricted, and that the increase in aggressive interactions is mainly for ewes fed grass silage.

  1. Anofelinos de Santa Catarina (Diptera: Culicidae, Brasil Anophelines of Santa Catarina (Diptera: Culicidae, Brazil

    Directory of Open Access Journals (Sweden)

    Maria da Graça Teixeira Portes

    2010-04-01

    Full Text Available INTRODUÇÃO: No Brasil, a Região Amazônica é endêmica em malária. Em Santa Catarina, a malária foi eliminada na década de 80. A partir daí, ocorreram poucos casos autóctones isolados, e esporádicos. No entanto, em função da existência do vetor em seu território, da existência de extensa área endêmica no Brasil e da grande mobilidade de pessoas em áreas turísticas no estado, existe a probabilidade de reintrodução da doença. MÉTODOS: Utilizou-se os seguintes dados: Banco de Dados do Núcleo de Entomologia da Fundação Nacional de Saúde, Santa Catarina (ACCES,1997-2000; Sistema de Informação de Vigilância Epidemiológica, Secretaria de Vigilância em Saúde (Malária/SC e Sistema de Informação de Notificação e Agravo(SINAN/SC. Os mesmos foram transportados e analisados, no programa Microsoft Office Excel 2007. RESULTADOS: As coletas foram realizadas em 48 municípios, 159 localidades, sendo identificados 12.310 Culicídeos, 11.546 (93,7% Anopheles e 764 (6,2% como outros. Foram identificados três subgêneros e 13 espécies de anofelinos. CONCLUSÕES: Considerando que nos municípios pesquisados, foi identificada a presença de importantes vetores como Anopheles cruzii e Anopheles albitasis e há circulação de pessoas infectadas provenientes de áreas endêmicas, pode-se considerar que os mesmos são áreas receptivas e vulneráveis à malária. Essas espécies são suspeitas de serem responsáveis pela transmissão de malária na região, principalmente nos municípios de Gaspar, Indaial e Rodeio.INTRODUCTION: The Amazon region of Brazil is endemic for malaria. In the State of Santa Catarina, malaria was eliminated in the 1980s. Since then, a few sporadic isolated autochthonous cases have occurred. However, because malaria vectors are present within Brazilian territory and extensive endemic areas exist in this country, along with the great mobility of people in tourist areas of Santa Catarina, there is the

  2. Evaluation of the laser methane detector to estimate methane emissions from ewes and steers.

    Science.gov (United States)

    Ricci, P; Chagunda, M G G; Rooke, J; M Houdijk, J G; Duthie, C-A; Hyslop, J; Roehe, R; Waterhouse, A

    2014-11-01

    The laser methane detector (LMD) has been proposed as a method to characterize enteric methane (CH4) emissions from animals in a natural environment. To validate LMD use, its CH4 outputs (LMD-CH4), were compared against CH4 measured with respiration chambers (chamber-CH4). The LMD was used to measure CH4 concentration (µL/L) in the exhaled air of 24 lactating ewes and 72 finishing steers. In ewes, LMD was used on 1 d for each ewe, for 2-min periods at 5 hourly observation periods (P1 to P5, respectively) after feeding. In steers fed either low- or high-concentrate diets, LMD was used once daily for a 4-min period for 3 d. The week after LMD-CH4 measurement, ewes or steers entered respiration chambers to quantify daily CH4 output (g/d). The LMD outputs consisted of periodic events of high CH4 concentrations superimposed on a background of oscillating lower CH4 concentrations. The high CH4 events were attributed to eructation and the lower background CH4 to respiration. After fitting a double normal distribution to the data set, a threshold of 99% of probability of the lower distribution was used to separate respiration from eructation events. The correlation between mean LMD-CH4 and chamber-CH4 was not high, and only improved correlations were observed after data were separated in 2 levels. In ewes, a model with LMD and DMI (adjusted R(2) = 0.92) improved the relationship between DMI and chamber-CH4 alone (adjusted R(2) = 0.79) and between LMD and chamber-CH4 alone (adjusted R(2) = 0.86). In both experiments, chamber-CH4 was best explained by models with length of eructation events (time) and maximum values of CH4 concentration during respiration events (µL/L; P LMD were observed from 3 to 5 h after feeding. Given the short time and ease of use of LMD, there is potential for its commercial application and field-based studies. Although good indicators of quantity of CH4 were obtained with respiration and eructation CH4, the method needed to separate the data into

  3. [Treatment of pelvic Ewing's sarcoma in children and the effect on the skeletal growth and development].

    Science.gov (United States)

    Fu, Jun; Guo, Zheng; Wang, Zhen; Li, Xiang-dong; Li, Jing; Chen, Guo-jing; Wu, Zhi-gang

    2012-12-01

    To explore the effect of neo-adjuvant chemotherapy and computer-assisted surgery on children and adolescents with primary pelvic Ewing's sarcoma, and assess the therapeutic effect on the pelvic skeletal growth and development. This is a retrospective analysis of 10 children with primary pelvic Ewing's sarcoma treated between Jan 2001 and Oct 2010 at the Department of Oncologic Orthopaedics at Xijing Hospital. There were 3 girls and 7 boys in the age of 7 to 16 years (average 12.7 years). All patients were pathologically diagnosed as Ewing's sarcoma. There were two cases in the sacroiliac joint, one in the ilium, one in the pubic bone, and 6 cases in peri-acetabular area including 5 below the triradiate cartilage and one above the triradiate cartilage, without cartilage invasion. All patients underwent neo-adjuvant chemotherapy, resection and reconstruction surgery and postoperative chemotherapy. CDP, ADM and IFO regimen chemotherapy were given as the main treatment. Five cases were treated by traditional resection and reconstruction, and after 2008, five cases were treated by computer-assisted surgery. During the reconstruction, the hip rotation center was put at a depressed location. All of the 10 cases underwent postoperative radiotherapy in a dose of 45-55 Gy. All patients were followed-up for 12-72 months (mean: 37.8 months). One child had tumor recurrence and lung metastasis and 9 patients had no evidence of disease (NED). After neo-adjuvant chemotherapy, the oncologic statuses (RECIST) were: 1 CR, 8 PR and 1 SD. The functional recoveries after surgery (Enneking's) were: 4 cases excellent, 4 good, 1 fair and 1 poor. Five cases who underwent computer-assisted surgery achieved a good reconstruction without local recurrence. There were no effects on skeletal growth in 8 cases. An unbalanced hip rotational center occurred in one case, and a compemsatory scoliosis was found in another case. There were no serious complications in all patients. The comprehensive

  4. Nutrition et santé : lipides et protéines d’origine végétale - De nouvelles données pour juger de la qualité des protéines végétales chez l’homme - Implications et perspectives

    Directory of Open Access Journals (Sweden)

    Mariotti François

    2003-01-01

    Full Text Available La qualité des protéines pour l’alimentation de l’homme est un sujet très ancien mais les différentes méthodes proposées jusqu’ici pour évaluer la qualité protéique ont été largement critiquées, pour des problèmes conceptuels et méthodologiques. Depuis quelques années des avancées ont pu être faites grâce à l’emploi d’isotopes stables dans la phase postprandiale chez l’homme. Ces techniques proposent des mesures fines et conceptuellement adaptées pour évaluer la qualité des protéines et explorer le concept de qualité protéique. Ces approches ont montré que les différences globales de qualités entre sources protéiques chez l’homme au bon statut nutritionnel sont bien plus faibles que cela n’était attendu. Parallèlement, la nature des protéines alimentaires pourrait avoir des effets métaboliques plus subtils, au niveau de certains tissus ou au niveau des voies métaboliques secondaires de certains acides aminés, dont il faudra mesurer l’étendue et évaluer les conséquences physiologiques et fonctionnelles.

  5. Effects of supplementing with calcium salts of palm oil fatty acids or hydrogenated tallow on ewe milk production and twin lamb growth.

    Science.gov (United States)

    Appeddu, L A; Ely, D G; Aaron, D K; Deweese, W P; Fink, E

    2004-09-01

    Two experiments were conducted with Polypay ewes nursing twin lambs to evaluate the effects of supplementing fat (calcium salts of palm oil fatty acids or hydrogenated tallow) on ewe lactation. In Exp. 1, ewes were fed a 52% concentrate:48% hay-based diet (as-fed basis) consisting of alfalfa hay (n = 4), endophyte-free fescue hay (n = 4), or fescue hay with 3.7% fatty acids (n = 4) from d 4 to 56 of lactation. In Exp. 2, ewes were fed similar diets that had endophyte-free fescue hay (n = 6), fescue hay with 3.7% fatty acids (n = 5), or fescue hay with 3.1% tallow (n = 6) from d 14 before lambing until d 57 of lactation. Diet formulations with supplemental fat were more nutrient dense, and treatments were fed to meet ewe nutrient requirements; this caused diets with added fat to be offered at 10 and 17% lower rates than unsupplemented diets in Exp. 1 and 2, respectively. Lambs were maintained to consume only ewe milk. Ewe milk production and composition were determined using a portable milking machine following a 3-h separation from lambs. In Exp. 1, milk fat content was increased (P tallow (290 vs. 210 g/d). The proportion of synthesized milk fat 14:0 was decreased (P tallow was added. Although ewe weight measures were not changed in Exp. 2, twin lamb gain per ewe organic matter intake was most efficient (P tallow decreased nutrient availability for ewe milk fat production. A complete diet based on endophyte-free fescue hay can replace a traditional alfalfa hay diet, whereas supplementing with the calcium salts of palm oil fatty acids may be more feasible when energy is limiting during ewe lactation.

  6. Incidence of infection in 39-month-old ewes with TMEM154 diplotypes "1 1," "1 3," and "3 3" after natural exposure to ovine progressive pneumonia virus.

    Science.gov (United States)

    Leymaster, K A; Chitko-McKown, C G; Heaton, M P

    2015-01-01

    Production and well-being of sheep and goats in many countries are harmfully impacted by small ruminant lentiviruses (SRLV) that cause incurable, progressive diseases. Susceptibility to ovine progressive pneumonia virus (OPPV), the North American form of SRLV, is influenced by variants of the ovine transmembrane protein 154 gene (TMEM154). The experimental objective was to estimate additive and dominance effects of TMEM154 haplotypes 1 and 3 on susceptibility of breeding ewes to infection after natural exposure to OPPV from birth to 39 mo of age. Sires and dams were heterozygous for TMEM154 haplotypes 1 and 3, producing ewe lambs with diplotypes "1 1," "1 3," and "3 3." These lambs were raised by mature, infected dams to ensure natural, maternal exposure to OPPV. Ewe lambs (n = 108) were kept for breeding and joined an infected flock of ewes to guarantee natural, nonmaternal exposure to OPPV. Ewes were bred to lamb at 1, 2, and 3 yr of age. Serum samples were collected at breeding, 1 mo before lambing and shortly after weaning each year to monitor infection status to 39 mo of age. During the experiment, 9 of the 108 ewes died while uninfected and data collected on these ewes were not analyzed. Infection status of the remaining 99 ewes at 39 mo of age was analyzed using logistic regression procedures. Effects of ewe type of birth, ewe type of rearing, and breed type of dam were not detected (P > 0.10), and the estimated sire variance component was nil. Ewe diplotype affected infection status (P sheep that are genetically less susceptible to OPPV infection.

  7. Utjecaj mjerila karte na određivanje duljine obalne crte i površine otoka u Jadranskom moru - primjer otoka Raba

    OpenAIRE

    2006-01-01

    Opisan je postupak određivanja duljine obalne crte i površine otoka Raba s karata mjerila 1:25 000, 1:50 000, 1:100 000, 1:200 000, 1:300 000, 1:500 000, 1:1 000 000 i 1:2 000 000. Listovi karata u mjerilu 1:25 000, 1:100 000 i 1:200 000 dobiveni su u georeferenciranom rasterskom formatu, a ostali su skenirani i georeferencirani. Izvršena je potom ručna vektorizacija obalne crte i transformacija svih koordinata u 5. zonu Gauss-Krügerove projekcije. Duljina obalne crte i površina otoka izračun...

  8. Améliorer l’évaluation de l’allergénicité de nouvelles protéines alimentaires : quels outils pour le futur ?

    OpenAIRE

    Denery-Papini, Sandra; Larré, Colette; Lollier, Virginie

    2016-01-01

    De nouveaux ingrédients protéiques vont être mis sur le marché et nécessiteront une évaluation du risque d’allergie alimentaire. L’article mentionne les limites des méthodes actuelles pour prédire ce risque et présente des méthodes in vitro et des modèles cellulaires en cours de développement choisis sur la base des étapes clés de l’allergie. Une approche pertinente doit prendre en compte à la fois la propriété des protéines à déclencher des réactions allergiques chez les personnes déjà aller...

  9. Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: A systematic review.

    Science.gov (United States)

    Ray, J G; Laskin, C A

    1999-09-01

    Placental infarction or abruption, recurrent pregnancy loss and pre-eclampsia are thought to arise due to defects within the placental vascular bed. Deficiencies of vitamin B12 and folate, or other abnormalities within the methionine-homocyst(e)ine pathway have been implicated in the development of such placental diseases. We conducted a systematic literature review to quantify the risk of placental disease in the presence of these metabolic defects. Studies were identified through OVID Medline between 1966 and February 1999. Terms relating to the measurement of vitamin B12, folic acid, methylenetetrahydrofolate reductase or homocyst(e)ine were combined with those of pre-eclampsia, placental abruption/infarction or spontaneous and habitual abortion. Human studies comprising both cases and controls and published in the English language were accepted. Their references were explored for other publications. Data were abstracted on the matching of cases with controls, the mean levels of folate, B12 or homocyst(e)ine in each group or the frequency of the homozygous state for the thermolabile variant of methylenetetrahydrofolate reductase. The definition of 'abnormal' for each exposure was noted and the presence or absence of the exposure of interest for each outcome was calculated as an absolute rate with a 95 per cent confidence interval. The crude odds ratios were calculated for each study and then pooled using a random effects model. Eighteen studies were finally included. Eight studies examined the risk of placental abruption/infarction in the presence of vitamin B12 or folate deficiency, or hyperhomocyst(e)inaemia. Folate deficiency was a prominent risk factor for placental abruption/infarction among four studies, though not statistically significant (pooled odds ratio 25.9, 95 per cent CI 0.9-736.3). Hyperhomocyst(e)inaemia was also associated with placental abruption/infarction both without (pooled odds ratio 5.3, 95 per cent CI 1.8-15.9) and with methionine

  10. La granitula de la Santa du Niolu

    Directory of Open Access Journals (Sweden)

    Davia Benedetti

    2012-01-01

    Full Text Available Abstract – IT   Quale modalità sociale fonda la pratica di una danza rituale pre-cristiana, la granitula, in occasione della festa annuale della Santa nel Niolo, in Corsica? Questa danza vi perdura nel quadro di un pellegrinaggio istituito sulla base di un racconto leggendario, in commemorazione della natività della Vergine. Essa è associata a una cerimonia religiosa e a una fiera. Consiste in una marcia a spirale a doppio senso, scandita da canti e condotta dai membri delle confraternite. La granitula ha rilievo nel campo etno-scenologico con la trasposizione corporea di immagini del labirinto, dell'origine e del sé. Simboleggia il corpo sociale corso e il suo senso d'appartenenza regionale e paesana. Coloro che la eseguono entrano in coesione con la comunità corsa. Fanno corpo con essa per proiettare nel vivere comune della società la loro assicurazione di uscita da ogni labirinto grazie a una prassi solidare, al rinserrare dei legami comunitari e a un adattamento identitario ai cambiamenti. Abstract – FR Quelle sociabilité fonde la pratique d’une danse rituelle antechrétienne, la granitula, lors de la fête annuelle de la Santa dans le Niolu, en Corse? Cette danse y perdure dans le cadre d’un pèlerinage établi sur un récit légendaire, en commémoration de la nativité de la Vierge. Elle est associée à une cérémonie religieuse catholique et à une foire. Elle consiste en une marche spiralée à double sens, scandée par des chants et exécutée par les membres des confréries. La granitula relève du champ de l’ethnoscénologie avec une mise en corps des figures du labyrinthe, de l’origine et du même. Elle symbolise le corps social corse et ses sentiments d’appartenance régionale et villageoise. Ses exécutants entrent en cohésion avec la communauté corse. Ils font corps avec elle pour projeter dans le vivre ensemble sociétal leur assurance de la sortie de tout labyrinthe par une pratique des solidarit

  11. The 2 MW Santa Clara Project

    Science.gov (United States)

    Eichenberger, Paul H.

    The City of Santa Clara, CA, USA, has hosted the world's first field demonstration of a molten carbonate fuel cell power plant. This US$46 million, 2 MW generator was a joint effort of five US utilities, the federal government, and two US research organizations. The demonstration used sixteen 125 kW stacks placed in four modules. The balance of plant (BOP) is the equipment that prepares and supplies the fuel to the stacks and converts the d.c. current to a.c. BOP construction started in April 1994, and was completed in June 1995. The BOP configuration allowed testing and development before installation of the four modules. The final full-temperature test was completed in February 1996. The four fuel cell modules were installed and cured, and power delivery began in April 1996. The plant operated for approximately 720 h at design output before electrical anomalies occurred and the plant was shut down for repairs. The plant restarted in August, but it soon became obvious that other problems had been caused by the electrical anomalies. The plant shut down and was reconfigured to a 1 MW plant. The restarted plant was ramped to 1 MW, but additional problems began to occur and the plant demonstration ended. The plant produced 2500 MWh, and operated at 1000°F, or higher, for over 5290 h. The plant set operational records, and demonstrated multistack, automatic control, and stable-field operation. Power quality met all standards with no measurable NOx or SOx output. The plant isolated itself from the grid during two major California, USA grid outages. The plant also experienced a shutdown of the automatic control system, and placed itself on hot standby using the mechanical field systems. The plant then restarted without incident.

  12. Radiotherapy and high-dose chemotherapy in advanced Ewing's tumors

    Energy Technology Data Exchange (ETDEWEB)

    Pape, H.; Glag, M.; Gripp, S.; Wittkamp, M.; Schmitt, G. [Duesseldorf Univ. (Germany). Klinik und Poliklinik fuer Strahlentherapie und Radiologische Onkologie; Laws, H.J.; Kaik, B. van; Goebel, U. [Duesseldorf Univ. (Germany). Abt. Paediatrische Haematologie und Onkologie; Burdach, S. [Halle Univ. (Germany). Abt. Paediatrie; Juergens, H. [Muenster Univ. (Germany). Abt. Paediatrische Hematologie und Onkologie

    1999-10-01

    Background: Ewing's tumors are sensitive to radio- and chemotherapy. Patients with multifocal disease suffer a poor prognosis. Patients presenting primary bone marrow involvement or bone metastases at diagnosis herald a 3-year disease-free survival below 15%. The European Intergroup Cooperative Ewing's Sarcoma Study (EICESS) has established the following indications for high-dose therapy in advanced Ewing's tumors: Patients with primary multifocal bone disease, patients with early (<2 years after diagnosis) or multifocal relapse. Patients and Method: As of 1987, 83 patients have been treated in the EICESS group, 39 of them at the transplant center in Duesseldorf, who have been analyzed here. All individuals received 4 courses of induction chemotherapy with EVAJA and stem cell collection after course 3 and 4. Consolidation radiotherapy of the involved bone compartments was administered in a hyperfractionated regimen 2 times 1.6 Gy per day, up to 22.4 Gy simultaneously to course 5 and 22.4 Gy to course 6 of chemotherapy. The myeloablative chemotherapy consisted of melphalan and etoposide (ME) in combination with 12 Gy TBI (Hyper-ME) oder Double-ME with whole lung irradiation up to 18 Gy (without TBI). Results: The survival probability at 40 months was 31% (44% DOD; 15% DOC). Pelvic infiltration did not reach prognostic relevance in this cohort. Radiotherapy encompassed 75% of the bone marrow at maximum (average 20%). Engraftment was not affected by radiotherapy. Conclusion: High-dose chemotherapy can improve outcome in poor prognostic advanced Ewing's tumors. The disease itself remains the main problem. The expected engraftment problems after intensive radiotherapy in large volumes of bone marrow can be overcome by stem cell reinfusion. (orig.) [German] Hintergrund: Ewing-Tumoren sind radio- und chemosensibel. Im metastasierten Stadium ist die Prognose schlecht. Patienten mit Knochen- oder Knochenmarkinfiltration haben nach drei Jahren eine

  13. Santa Elena. Ready to reshape its transport energy matrix

    Energy Technology Data Exchange (ETDEWEB)

    Moreano, Hernan [Universidad Estatal Peninsula de Santa Elena (Ecuador). Inst. de Investigacion Cientifica y Desarrollo Tecnologico (INCYT)

    2012-07-01

    The renewable energy issue opens the door to an ambient of opportunities. Santa Elena, one of the coastal provinces of Ecuador has the chance to go from a fossil fuel energy culture to a new energy scheme based on the use of environmental friendly fuels like natural gas and other renewable energy carriers like hydrogen. The marginal production of oil and natural gas from the Gustavo Galindo Velasco field and the updated gas reserves from the Gulf of Guayaquil make it possible. Infrastructure for natural gas production and distribution for vehicles is almost ready and any of the three refineries can generate hydrogen from natural gas. This provides the opportunity to reshape the Santa Elena transport energy matrix, where vehicles can burn natural gas and inter country buses can work with hydrogen. Traditional Fishing boats can be fitted with hydrogen storage and fuel systems later on. Santa Elena should face this challenge through a joint effort of public and private parties. Santa Elena State University and its partners as a focus point to create: The Campus of Energy Knowledge, where research, science and technology will serve companies that work in the energy business with a strong synergy, which will create jobs for the Santa Elena people. (orig.)

  14. Santa Fe Alliance for Science: The First Eight Years

    Science.gov (United States)

    Eisenstein, Robert A.

    2013-04-01

    The Santa Fe Alliance for Science (SFAFS) was founded in May, 2005. SFAFS exists to provide assistance in K-14 math and science education in the greater Santa Fe area. It does this via extensive programs (1) in math and science tutoring at Santa Fe High School, Santa Fe Community College and to a lesser degree at other schools, (2) science fair advising and judging, (3) its ``Santa Fe Science Cafe for Young Thinkers'' series, (4) a program of professional enrichment for K-12 math and science teachers, and (5) a fledging math intervention program in middle school math. Well over 150 STEM professionals, working mostly as volunteers, have contributed since our beginning. Participation by students, parents and teachers has increased dramatically over the years, leading to much more positive views of math and science, especially among elementary school students and teachers. Support from the community and from local school districts has been very strong. I will present a brief status report on SFAFS activities, discuss some of the lessons learned along the way and describe briefly some ideas for the future. More information can be found at the SFAFS website, www.sfafs.org.

  15. Influence of ventilation regimen on micro-environment and on ewe welfare and milk yield in summer

    Directory of Open Access Journals (Sweden)

    Mariangela Caroprese

    2010-01-01

    Full Text Available The effects of ventilation regimen on air quality, and on the welfare and production performance of thirty-six Comisanaewes were assessed in a 6-week trial conducted during the summer of 2002. Animals were divided into three groups of12, and subjected to the following treatments: low ventilation regimen providing a mean ventilation rate (VR of 35 m3/hper ewe, split in 30 min ventilation cycles at an air speed of 2 m/s (LOV-30; moderate ventilation regimen (VR = 70m3/h per ewe split in 30 min ventilation cycles at an air speed of 4 m/s (MOV-30; moderate ventilation regimen (VR =70 m3/h per ewe split in 60 min ventilation cycles at an air speed of 2 m/s (MOV-60. Air concentrations of microorganisms,dust, and gaseous pollutants were measured twice weekly. Respiration rate (RR and rectal temperature (RTwere monitored throughout the trial at 0830 and at 1400. Behavioral traits of ewes were recorded twice per week from0900 to 1200 and from 1500 to 1800. Cell-mediated immune response to phytohemagglutinin (PHA and humoralimmune response to chicken egg albumin were determined. At d 37 ewes were injected with porcine ACTH, and subjectedto blood sampling for evaluation of cortisol concentrations immediately before and 1, 2 and 4 h after ACTH injection.Milk yield was recorded daily. Individual milk samples were analyzed for composition, renneting parameters, somaticcell count (SCC, and bacteriological characteristics. Averages of maximum THI were about 3 points higher in the LOV-30 and the MOV-30 than in the MOV-60 room, whereas no differences emerged in the air concentrations of dust, gaseouspollutants and microorganisms. Significant interactions of treatment x time (P and for the time the ewes spent lying, idling and eating in the afternoon during weeks 2 and 3 of the study period.Significant effects of ventilation regimen x time (P the LOV-30 ewes giving smaller volumes of milk with a deteriorated coagulating behavior than those of the MOV-60 group

  16. Eficiência bioeconômica de cordeiros F1 Dorper x Santa Inês para produção de carne Bioeconomic efficiency of F1 Dorper x Santa Inês lambs for meet production

    Directory of Open Access Journals (Sweden)

    Nelson Nogueira Barros

    2005-08-01

    Full Text Available O objetivo deste trabalho foi avaliar a eficiência bioeconômica de cordeiros F1 Dorper x Santa Inês para produção de carne. Analisou-se o desempenho de ovinos ½ sangue Dorper x ½ sangue Santa Inês, nas fases de cria e de acabamento. A fase de produção das crias foi realizada em caatinga nativa e a fase de acabamento em confinamento. As matrizes foram suplementadas nos últimos 50 dias de prenhez e nos primeiros 30 dias de lactação. As crias foram desmamadas aos 70 dias de idade, divididas em três lotes e confinadas, alimentadas com capim-elefante (Pennisetum purpureum ad libitum e concentrado na proporção de 1,5%, 2,5% e 3,5% do peso vivo, respectivamente. O sexo não exerceu influência sobre os pesos no nascimento, no desmame, nem sobre o ganho em peso até o desmame. Não foi observada influência do sexo sobre os pesos e os ganhos em peso aos 30 e 50 dias de confinamento. Nas fases de produção e acabamento em confinamento, os animais de nascimento simples foram superiores aos de nascimento duplo quanto a essas variáveis. Houve efeito linear significativo para peso e ganho em peso aos 30 e 50 dias de confinamento. Os três níveis de uso de concentrado foram economicamente viáveis. As margens brutas de peso vivo, por kg de cordeiro produzido, foram de R$ 0,26 kg-1, R$ 0,30 kg-1 e R$ 0,36 kg-1 para concentrados a 1,5%, 2,5% e 3,5% do peso vivo, respectivamente. Os melhores resultados econômicos foram obtidos quando o nível de concentrado foi de 3,5% do peso vivo.The objective of this work was to evaluate bioeconomic efficiency of F1 Dorper x Santa Inês lambs for meet production. Performance of F1 Dorper x Santa Inês lambs in raising and fattening phases was analyzed. The production phase of lambs was realized in native pastures ("caatinga" and the finishing phase was in confinement. The ewes were supplemented during the last 50 days of pregnancy and the first 30 days of lactation. Lambs were weaned at 70 days of age

  17. SRTM Perspective View with Landsat Overlay: Santa Paula, and Santa Clara River Valley, California

    Science.gov (United States)

    2000-01-01

    Rectangular fields of the agriculturally rich Santa Clara River Valley are visible in this perspective view generated using data from the Shuttle Radar Topography Mission and an enhanced Landsat image. The Santa Clara River, which lends its name to this valley, flows from headwaters near Acton, California, 160 km (100 miles) to the Pacific Ocean, and is one of only two natural river systems remaining in southern California. In the foreground of this image, the largely dry riverbed can be seen as a bright feature as it winds its way along the base of South Mountain. The bright region at the right end of this portion of the valley is the city of Santa Paula, California. Founded in 1902, this small, picturesque town at the geographic center of Ventura County is referred to as the 'Citrus Capital of the World.' The city is surrounded by orange, lemon, and avocado groves and is a major distribution point for citrus fruits in the United States. The bright, linear feature in the center of the valley is State Highway 126, the valley's 'main drag.' For visualization purposes, topographic heights displayed in this image are exaggerated two times. Colors, from Landsat data, approximate natural color.The elevation data used in this image was acquired by SRTM aboard the Space Shuttle Endeavour, launched on February 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on Endeavour in 1994. SRTM was designed to collect three-dimensional measurements of Earth's land surface. To collect the 3-D SRTM data, engineers added a mast 60 meters (about 200 feet)long, installed additional C-band and X-band antennas, and improved tracking and navigation devices. The mission is a cooperative project between the NASA, the National Imagery and Mapping Agency (NIMA) of the U.S. Department of Defense, and the German and Italian space agencies. It is managed by NASA's Jet Propulsion Laboratory

  18. Reproductive Response of Ewes Fed with Taiwan Grass Hay (Pennisetum purpureum Schum.) Supplemented with Duckweed (Lemna sp. and Spirodela sp.)

    Science.gov (United States)

    Zetina-Córdoba, P.; Ortega-Cerrilla, M. E.; Sánchez Torres-Esqueda, M. T.; Herrera-Haro, J. G.; Ortega-Jiménez, E.; Reta-Mendiola, J. L.; Vilaboa-Arroniz, J.

    2012-01-01

    The effect of duckweed (DW) supplementation was evaluated on dry matter intake (DMI), presence and duration of estrus, percentage of ewes repeating estrus and pregnancy rate, as well as the concentration of progesterone (P4) in multiparous crossbred ewes from Pelibuey, Dorper, and Katahdin breeds, fed with Taiwan grass hay (TWH). Eighteen ewes with 39.7±4 kg mean body weight, kept in individual pens, were randomly assigned to one of the following treatments: T1: TWH, T2: TWH plus 200 g DW, T3: TWH plus 300 g DW. The ewes were synchronized with 40 mg fluorogestone acetate (FGA) and 400 UI equine chorionic gonadotropin (eCG). Data were analyzed as a completely randomized design using the GLM procedure. DW supplementation had no effect on dry matter intake (p>0.05); however, a slight decrease of TWH intake was observed as DW supplementation increased. No differences (p>0.05) were found in the beginning of estrus, percentage of ewes presenting it, its duration, or pregnancy rate. There were no differences (p>0.05) on P4 concentration among treatments, or treatmentxperiod interaction (p>0.05). However the period was significant (p<0.01), since the P4 levels increased as time increased after the removal of the FGA device and eCG application. PMID:25049670

  19. Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Mérino ewes

    Science.gov (United States)

    Mulsant, Philippe; Lecerf, Frédéric; Fabre, Stéphane; Schibler, Laurent; Monget, Philippe; Lanneluc, Isabelle; Pisselet, Claudine; Riquet, Juliette; Monniaux, Danielle; Callebaut, Isabelle; Cribiu, Edmond; Thimonier, Jacques; Teyssier, Jacques; Bodin, Loys; Cognié, Yves; Chitour, Nour; Elsen, Jean-Michel

    2001-01-01

    Ewes from the Booroola strain of Australian Mérino sheep are characterized by high ovulation rate and litter size. This phenotype is due to the action of the FecBB allele of a major gene named FecB, as determined by statistical analysis of phenotypic data. By genetic analysis of 31 informative half-sib families from heterozygous sires, we showed that the FecB locus is situated in the region of ovine chromosome 6 corresponding to the human chromosome 4q22–23 that contains the bone morphogenetic protein receptor IB (BMPR-IB) gene encoding a member of the transforming growth factor-β (TGF-β) receptor family. A nonconservative substitution (Q249R) in the BMPR-IB coding sequence was found to be associated fully with the hyperprolificacy phenotype of Booroola ewes. In vitro, ovarian granulosa cells from FecBB/FecBB ewes were less responsive than granulosa cells from FecB+/FecB+ ewes to the inhibitory effect on steroidogenesis of GDF-5 and BMP-4, natural ligands of BMPR-IB. It is suggested that in FecBB/FecBB ewes, BMPR-IB would be inactivated partially, leading to an advanced differentiation of granulosa cells and an advanced maturation of ovulatory follicles. PMID:11320249

  20. Primary vaginal Ewing's sarcoma or primitive neuroectodermal tumor in a 17-year-old woman: a case report

    Directory of Open Access Journals (Sweden)

    Kurkure Purna

    2010-03-01

    Full Text Available Abstract Introduction Primary Ewing's sarcoma or primitive neuroectodermal tumor of the genital tract of women is uncommon. Rarer still is its occurrence in the vagina, with only five cases described so far. Out of these, only one case was confirmed using molecular analysis. Case presentation We present an extremely rare case of Ewing's sarcoma or primitive neuroectodermal tumor in a 17-year-old Indian girl. She presented with a vaginal mass that was initially diagnosed as a malignant round cell tumor. Immunohistochemistry showed diffuse positivity for vimentin, membranous positivity for MIC2, and positivity for BCL2 and FLI-1. On the other hand, she was negative for cytokeratin, epithelial membrane antigen, desmin, Myo D-1, myogenin and smooth muscle actin. A diagnosis of primitive neuroectodermal tumor was thus offered. Furthermore, a molecular analysis of our patient using reverse transcription-polymerase chain reaction technique showed positivity for t(11; 22 (q24; q12 (EWSR1-FLI1, thus confirming the diagnosis of a Ewing's sarcoma/primitive neuroectodermal tumor. Our patient was offered chemotherapy on Institutional protocol EFT 2001. Conclusion This is a rare case of primary vaginal Ewing's sarcoma or primitive neuroectodermal tumor, which was confirmed with molecular analysis, in the youngest patient known so far. This study reinforces the value of integrating morphological features with membranous MIC2 positivity, along with application of molecular techniques in objective identification of an Ewing's sarcoma or primitive neuroectodermal tumor at uncommon sites.