WorldWideScience

Sample records for sanrimgyeongje including twelve

  1. Margalef revisited: A new phytoplankton mandala incorporating twelve dimensions, including nutritional physiology.

    Science.gov (United States)

    Glibert, Patricia M

    2016-05-01

    Building on the classic depiction of the progression from a diatom to a dinoflagellate bloom as a function of nutrients and turbulence, known as the "Margalef mandala", a new conceptual model or mandala is presented here. The new mandala maps twelve response or effects traits, or environmental characteristics, related to different phytoplankton functional types: (1) relative preference for chemically reduced vs chemically oxidized forms of nitrogen; (2) relative availability of inorganic nitrogen and phosphorus; (3) adaptation to high vs low light and the tendency to be autotrophic vs mixotrophic; (4) cell motility; (5) environmental turbulence; (6) pigmentation quality; (7) temperature; (8) cell size; (9) relative growth rate; (10) relative production of bioactive compounds such as toxins or reactive oxygen species (ROS); (11) r vs K strategy; and (12) fate of the production in terms of grazing. The new mandala serves to highlight the differences and trade-offs between traits and/or environmental conditions, and illustrates some traits tend to track each other, a concept that may be helpful in trait-based modeling approaches and in understanding environmental factors associated with harmful algal blooms. It is hoped that this new mandala captures some of our recent insight into phytoplankton physiology and functional traits, and has contemporary relevance in light of anthropogenic changes in nutrient form and ratio. Copyright © 2016 Elsevier B.V. All rights reserved.

  2. Margalef revisited: A new phytoplankton mandala incorporating twelve dimensions, including nutrient ratios and forms

    Science.gov (United States)

    Glibert, P. M.

    2016-02-01

    Building on the classic depiction of the progression from a diatom to a dinoflagellate bloom as a function of nutrients and turbulence, known as the "Margalef mandala", a new conceptual model or mandala is presented here. The new mandala maps twelve traits or environmental characteristics related to different phytoplankton functional types: (1) relative preference for chemically reduced vs chemically oxidized forms of nitrogen; (2) relative availability of inorganic nitrogen and phosphorus; (3) adaptation to high vs low light and the tendency to be autotrophic vs mixotrophic; (4) cell motility; (5) environmental turbulence; (6) pigmentation quality; (7) temperature; (8) cell size; (9) relative growth rate; (10) relative production of bioactive compounds such as toxins or reactive oxygen species (ROS); (11) r vs K strategy; and (12) fate of the production in terms of grazing. The new mandala serves to highlight the differences and trade-offs between traits and/or environmental conditions, and illustrates some traits tend to track each other, a concept that may be helpful in trait-based modeling approaches. It is hoped that this new mandala captures some of our recent insight into phytoplankton physiology and functional traits, and has contemporary relevance in light of anthropogenic changes in nutrient form and ratio.

  3. Review of the Spirobolida on Madagascar, with descriptions of twelve new genera, including three genera of 'fire millipedes' (Diplopoda

    Directory of Open Access Journals (Sweden)

    Thomas Wesener

    2009-09-01

    Full Text Available Twelve new genera and 37 new species of Spirobolida are described: Corallobolus cruentus gen. n., sp. n., Sanguinobolus maculosus gen. n., sp. n., Colossobolus semicyclus gen. n., sp. n., C. oblongopedus sp. n., C. giganteus sp. n., C. minor sp. n., C. litoralis sp. n., C. aculeatus sp. n., C. pseudoaculeatus sp. n., Zehntnerobolus gen. n., Flagellobolus pauliani gen. n., sp. n., Riotintobolus mandenensis gen. n., sp. n., R. minutus sp. n., R. aridus sp. n., R. anomalus sp. n., Pseudocentrobolus aureus gen. n., sp. n., P. vohibasiensis sp. n., Granitobolus endemicus gen. n., sp. n., G. andohahelensis sp. n., Caprobolus andringitra gen. n., sp. n., Alluviobolus laticlavius gen. n., sp. n., A. tsimelahy sp. n., A. antanosy sp. n., Ostinobolus rufus gen. n., sp. n., O. stellaris sp. n., O. montanus sp. n., O. subterraneus sp. n., and Hylekobolus brachiosauroides gen. n., sp. n., H. rufus sp. n., H. griseus sp. n., H. albicollaris sp. n., H. goodmani sp. n., H. montanus sp. n., H. analavelona sp. n., H. latifrons sp. n., H. andasibensis sp. n., H. marojejy sp. n., H. anjanaharibe sp. n. All genera and species are endemic to Madagascar. Hylekobolus belongs to the family Spirobolellidae, while all other Malagasy genera of Spirobolida belong to the Pachybolidae. Among them, only Zehntnerobolus gen. n. is based on a previously described species: Spirobolus rubripes de Saussure & Zehntner, 1897, whereas the remaining 11 new genera altogether contain (a total of 37 new species. Three of the new genera are large-bodied “fire millipedes” (>100 mm long with striking red/black colour patterns. The new discoveries increase the number of endemic Malagasy genera of Spirobolida more than fivefold (from 3 to 15. The number of endemic species recorded from Madagascar has more than doubled (to 61. Body length of the new species varies greatly (between 23 and 170 mm. Keys to all Malagasy Spirobolida families, genera, as well as the newly described species

  4. The Twelve Hotel, Barna : Video

    OpenAIRE

    Irish Food Channel

    2014-01-01

    Fergus O'Halloran, Managing Director of The Twelve Hotel in Barna in County Galway, talks about his philosophy in running this unique boutique hotel. Reproduced with kind permission from John & Sally McKenna. 3.35 mins

  5. Transanal rectopexy - twelve case studies

    Directory of Open Access Journals (Sweden)

    Rubens Henrique Oleques Fernandes

    2012-06-01

    Full Text Available OBJECTIVES: This study analyzed the results of transanal rectopexy and showed the benefits of this surgical technique. METHOD: Twelve patients were submitted to rectopexy between 1997 and 2011. The surgical technique used was transanal rectopexy, where the mesorectum was fixed to the sacrum with nonabsorbable suture. Three patients had been submitted to previous surgery, two by the Delorme technique and one by the Thiersch technique. RESULTS: Postoperative hospital stay ranged from 1 to 4 days. One patient (8.3% had intraoperative hematoma, which was treated with local compression and antibiotics. One patient (8.3% had residual mucosal prolapse, which was resected. Prolapse recurrence was seen in one case (8.3%. Improved incontinence occurred in 75% of patients and one patient reported obstructed evacuation in the first month after surgery. No death occurred. CONCLUSION: Transanal rectopexy is a simple, low cost technique, which has shown good efficacy in rectal prolapse control.OBJETIVO: O presente estudo analisou os resultados da retopexia pela via transanal e expôs os benefícios desta técnica cirúrgica. MÉTODO: Doze pacientes com prolapso foram operados no período de 1997 a 2011. A técnica cirúrgica usada foi a retopexia transanal, onde o mesorreto foi fixado ao sacro com fio inabsorvível. Três pacientes tinham cirurgia prévia, dois pela técnica de Delorme e um pela técnica de Thiersch. RESULTADOS: A permanência hospitalar pós-operatória variou de 1- 4 dias. Uma paciente (8,3% apresentou hematoma transoperatório que foi tratado com compressão local e antibioticoterapia. Um paciente apresentou prolapso mucoso residual (8,3%, que foi ressecado. Houve recidiva da procidência em um caso (8,3%. A melhora da incontinência ocorreu em 75% dos pacientes e uma paciente apresentou bloqueio evacuatório no primeiro mês após a cirurgia. Não houve mortalidade entre os pacientes operados. CONCLUSÃO: A retopexia transanal é uma t

  6. Combining ability of twelve maize populations

    Directory of Open Access Journals (Sweden)

    Vacaro Elton

    2002-01-01

    Full Text Available Genetic progress depends on germplasm quality and breeding methods. Twelve maize populations and their crosses were evaluated to estimate combining ability and potential to be included as source populations in breeding programs. Plant height, point of insertion of the first ear, number of ears per plant, number of grains per ear, root and stalk lodging and grain yield were studied in two locations in Brazil, during the 1997/98 season. Genotype sum of squares was divided into general (GCA and specific (SCA combining ability. Results indicated the existence of genetic divergence for all traits analyzed, where additive effects were predominant. The high heterosis levels observed, mainly in Xanxerê, suggested the environmental influence on the manifestation of this genetic phenomenon. Populations revealed potential to be used in breeding programs; however, those more intensively submitted to selection could provide larger genetic progress, showing the importance of population improvement for the increment of the heterosis in maize.

  7. The twelve dimensional super (2+2)-brane

    CERN Document Server

    Hewson, S F

    1996-01-01

    We discuss supersymmetry in twelve dimensions and present a covariant supersymmetric action for a brane with worldsheet signature (2,2), called a super (2+2)-brane, propagating in the osp(64,12) superspace. This superspace is explicitly constructed, and is trivial in the sense that the spinorial part is a trivial bundle over spacetime, unlike the twisted superspace of usual Poincare supersymmetry. For consistency, it is necessary to take a projection of the superspace. This is the same as the projection required for worldvolume supersymmetry. Upon compactification of this superspace, a torsion is naturally introduced and we produce the membrane and type IIB string actions in 11 and 10 dimensional Minkowski spacetimes. In addition, the compactification of the twelve dimensional supersymmetry algebra produces the correct algebras for these theories, including central charges. These considerations thus give the type IIB string and M-theory a single twelve dimensional origin.

  8. Family Textbooks Twelve Years Later

    Science.gov (United States)

    Glenn, Norval D.

    2009-01-01

    In 1996 the author conducted an intensive study of twenty current family textbooks published in the United States, the results of which appeared in an academic journal article and a nonacademic report in 1997. The study included practical "functionalist" marriage and family textbooks and more academic sociology of the family books; these…

  9. Twelve lectures on structural dynamics

    CERN Document Server

    Preumont, André

    2013-01-01

    This text addresses the modeling of vibrating systems with the perspective of finding the model of minimum complexity which accounts for the physics of the phenomena at play. The first half of the book (Ch.1-6) deals with the dynamics of discrete and continuous mechanical systems; the classical approach emphasizes the use of Lagrange's equations. The second half of the book (Ch.7-12) deals with more advanced topics, rarely encountered in the existing literature: seismic excitation, random vibration (including fatigue), rotor dynamics, vibration isolation and dynamic vibration absorbers; the final chapter is an introduction to active control of vibrations. The first part of this text may be used as a one semester course for 3rd year students in Mechanical, Aerospace or Civil Engineering. The second part of the text is intended for graduate classes. A set of problems is provided at the end of every chapter. The author has a 35 years experience in various aspects of Structural dynamics, both in industry (nuclea...

  10. Mythematics Solving the Twelve Labors of Hercules

    CERN Document Server

    Huber, Michael

    2009-01-01

    How might Hercules, the most famous of the Greek heroes, have used mathematics to complete his astonishing Twelve Labors? From conquering the Nemean Lion and cleaning out the Augean Stables, to capturing the Erymanthean Boar and entering the Underworld to defeat the three-headed dog Cerberus, Hercules and his legend are the inspiration for this book of fun and original math puzzles. While Hercules relied on superhuman strength to accomplish the Twelve Labors, Mythematics shows how math could have helped during his quest. How does Hercules defeat the Lernean Hydra and stop its heads from multip

  11. Comparative analysis of twelve Dothideomycete plant pathogens

    Energy Technology Data Exchange (ETDEWEB)

    Ohm, Robin; Aerts, Andrea; Salamov, Asaf; Goodwin, Stephen B.; Grigoriev, Igor

    2011-03-11

    The Dothideomycetes are one of the largest and most diverse groups of fungi. Many are plant pathogens and pose a serious threat to agricultural crops grown for biofuel, food or feed. Most Dothideomycetes have only a single host and related Dothideomycete species can have very diverse host plants. Twelve Dothideomycete genomes have currently been sequenced by the Joint Genome Institute and other sequencing centers. They can be accessed via Mycocosm which has tools for comparative analysis

  12. Twelve tips for peer observation of teaching.

    Science.gov (United States)

    Siddiqui, Zarrin Seema; Jonas-Dwyer, Diana; Carr, Sandra E

    2007-05-01

    This paper outlines twelve tips for undertaking peer observation of teaching in medical education, using the peer review model and the experiences of the authors. An accurate understanding of teaching effectiveness is required by individuals, medical schools, and universities to evaluate the learning environment and to substantiate academic and institutional performance. Peer Observation of Teaching is one tool that provides rich, qualitative evidence for teachers, quite different from closed-ended student evaluations. When Peer Observation of Teaching is incorporated into university practice and culture, and is conducted in a mutually respectful and supportive way, it has the potential to facilitate reflective change and growth for teachers.

  13. Twelve tips for getting your manuscript published.

    Science.gov (United States)

    Cook, David A

    2016-01-01

    The author shares twelve practical tips on how to navigate the process of getting a manuscript published. These tips, which apply to all fields of academic writing, advise that during the initial preparation phase authors should: (1) plan early to get it out the door; (2) address authorship and writing group expectations up front; (3) maintain control of the writing; (4) ensure complete reporting; (5) use electronic reference management software; (6) polish carefully before they submit; (7) select the right journal; and (8) follow journal instructions precisely. Rejection after the first submission is likely, and when this occurs authors should (9) get it back out the door quickly, but first (10) take seriously all reviewer and editor suggestions. Finally, when the invitation comes to revise and resubmit, authors should (11) respond carefully to every reviewer suggestion, even if they disagree, and (12) get input from others as they revise. The author also shares detailed suggestions on the creation of effective tables and figures, and on how to respond to reviewer critiques.

  14. Antifouling activity of twelve demosponges from Brazil

    Directory of Open Access Journals (Sweden)

    SM. Ribeiro

    Full Text Available Benthic marine organisms are constantly exposed to fouling, which is harmful to most host species. Thus, the production of secondary metabolites containing antifouling properties is an important ecological advantage for sessile organisms and may also provide leading compounds for the development of antifouling paints. High antifouling potential of sponges has been demonstrated in the Indian and Pacific oceans and in the Caribbean and Mediterranean seas. Brazilian sponges remain understudied concerning antifouling activities. Only two scientific articles reported this activity in sponges of Brazil. The objective of this study was to test crude extracts of twelve species of sponges from Brazil against the attachment of the mussel Perna perna through laboratorial assays, and highlight promising species for future studies. The species Petromica citrina, Amphimedon viridis, Desmapsamma anchorata, Chondrosia sp., Polymastia janeirensis, Tedania ignis, Aplysina fulva, Mycale angulosa, Hymeniacidon heliophila, Dysidea etheria, Tethya rubra, and Tethya maza were frozen and freeze-dried before extraction with acetone or dichloromethane. The crude extract of four species significantly inhibited the attachment of byssus: Tethya rubra (p = 0.0009, Tethya maza (p = 0.0039, Petromica citrina (p = 0.0277, and Hymeniacidon heliophila (p = 0.00003. These species, specially, should be the target of future studies to detail the substances involved in the ability antifouling well as to define its amplitude of action.

  15. Twelve Elastic Constants of Betula platyphylla Suk.

    Institute of Scientific and Technical Information of China (English)

    Wang Liyu; Lu Zhenyou

    2004-01-01

    Wood elastic constants are needed to describe the elastic behaviors of wood and be taken as an important design parameter for wood-based composite materials and structural materials. This paper clarified the relationships between compliance coefficients and engineering elastic constants combined with orthotropic properties of wood, and twelve elastic constants of Betula platyphylla Suk. were measured by electrical strain gauges. Spreading the adhesive quantity cannot be excessive or too little when the strain flakes were glued. If excessive, the glue layer was too thick which would influence the strain flakes' performance, and if too little, glues plastered were not firm, which could not accurately transmit the strain. Wood as an orthotropic material, its modulus of elasticity and poisson's ratios are related by two formulas:μij /Ei =μji /Ej and μij 0.95) between the reciprocal of elastic modulus MOE-1 and the square of the ratio of depth to length (h/l)2, which indicate that shear modulus values measured were reliable by three point bending experiment.

  16. Hepatic Angiosarcoma: a Review of Twelve Cases

    Institute of Scientific and Technical Information of China (English)

    Qiang Li; Xishan Hao

    2005-01-01

    OBJECTIVE Hepatic angiosarcoma (HAS), a lethal disease, is the most common sarcoma arising in the liver. Little information about the epidemiology, etiology, diagnosis and management of HAS has been reported. Increased familiarity with this disease will facilitate correct diagnosis and help to improve management of this condition in the future.The objective of this study was to describe cases of hepatic angiosarcoma and to discuss the etiologic, diagnostic, therapeutic features and prognosis of this tumor. This report not only serves to give more evidence of the relationship between hepatic angiosarcoma and carcinogenic exposure, but also demonstrates the key points in different methods of diagnosis and the optimal treatment of hepatic angiosarcoma.METHODS Twelve cases of hepatic angiosareoma were analyzed retrospectively, representing the different character in clinical presentations and laboratory computed tomographical scans; pathological data and treatment are described. Clinical and biologic follow-up was carried out for two years after surgical treatment.RESULTS There were nine men and three women varying in ages from 57 to 71 years with an average of 64.3 years. Ten patientshad a history of exposure to vinyl chloride or thorotrast. Mild or moderate abdominal pain and bloating, abdominal mass and fever were the common clinical presentations. Tumors were visualized by ultrasonography and CT scans in all patients. Biochemical profiles yielded variable results and proved to be of little value in detection or diagnosis. Surgical resection was feasible for each patient who was treated as follows: two wedge resections, six segementectomies and four bisegmentectomies. Five patients received Neoadjuvant chemotherapy postoperatively. The survival rate of those cases was poor. The maximum survival time was fourteen months. The mean survival time for this chemotherapeutic group was 11 months. The difference between the survival time of those treated with an operation

  17. Spectroscopy of twelve Type Ia supernovae at intermediate redshift

    CERN Document Server

    Balland, C; Pain, R; Walton, N A; Amanullah, R; Astier, Pierre; Ellis, Richard S; Fabbro, S; Goobar, A; Hardin, D; Hook, I M; Irwin, M J; McMahon, R M; Mendez, J M; Ruiz-Lapuente, P; Sainton, G; Schahmaneche, K; Stanishev, V

    2005-01-01

    We present spectra of twelve Type Ia supernovae obtained in 1999 at the William Herschel Telescope and the Nordic Optical Telescope during a search for Type Ia supernovae (SN Ia) at intermediate redshift. The spectra range from z=0.178 to z=0.493, including five high signal-to-noise ratio SN Ia spectra in the still largely unexplored range 0.15 < z < 0.3. Most of the spectra were obtained before or around restframe B-band maximum light. None of them shows the peculiar spectral features found in low-redshift over- or under-luminous SN Ia. Expansion velocities of characteristic spectral absorption features such as SiII at 6355 angs., SII at 5640 angs. and CaII at 3945 angs. are found consistent with their low-z SN Ia counterparts.

  18. Twelve Steps toward Revitalization for Teachers.

    Science.gov (United States)

    Newbrough, Art

    1983-01-01

    A dozen common sense ways to respond to and counter the teacher burnout syndrome are briefly discussed. Strategies include physical exercise, stress controls, recultivating special relationships, self-expressions, celebrations, enthusiasm maintenance, and professional support. The aticle is designed to help educators maintain a perspective on…

  19. Twelve new species of Triplocania Roesler (Psocodea: 'Psocoptera': Ptiloneuridae), from South America.

    Science.gov (United States)

    Silva Neto, Alberto Moreira Da; Aldrete, Alfonso N García; Rafael, José Albertino

    2016-05-09

    Twelve species of Triplocania, seven based on male and female specimens and five based on male specimens, are here described and illustrated; nine species are Brazilian, three are Ecuadorian, and one of the latter is shared with Peru. Comments on sexes known and distribution of the species are included.

  20. Twelve tips for facilitating Millennials' learning.

    Science.gov (United States)

    Roberts, David H; Newman, Lori R; Schwartzstein, Richard M

    2012-01-01

    The current, so-called "Millennial" generation of learners is frequently characterized as having deep understanding of, and appreciation for, technology and social connectedness. This generation of learners has also been molded by a unique set of cultural influences that are essential for medical educators to consider in all aspects of their teaching, including curriculum design, student assessment, and interactions between faculty and learners.  The following tips outline an approach to facilitating learning of our current generation of medical trainees.  The method is based on the available literature and the authors' experiences with Millennial Learners in medical training.  The 12 tips provide detailed approaches and specific strategies for understanding and engaging Millennial Learners and enhancing their learning.  With an increased understanding of the characteristics of the current generation of medical trainees, faculty will be better able to facilitate learning and optimize interactions with Millennial Learners.

  1. Twelve novel Atm mutations identified in Chinese ataxia telangiectasia patients.

    Science.gov (United States)

    Huang, Yu; Yang, Lu; Wang, Jianchun; Yang, Fan; Xiao, Ying; Xia, Rongjun; Yuan, Xianhou; Yan, Mingshan

    2013-09-01

    Ataxia telangiectasia (A-T) is an autosomal recessive disease characterized mainly by progressive cerebellar ataxia, oculocutaneous telangiectasia, and immunodeficiency. This disease is caused by mutations of the ataxia telangiectasia mutated (Atm) gene. More than 500 Atm mutations that are responsible for A-T have been identified so far. However, there have been very few A-T cases reported in China, and only two Chinese A-T patients have undergone Atm gene analysis. In order to systemically investigate A-T in China and map their Atm mutation spectrum, we recruited eight Chinese A-T patients from six unrelated families nationwide. Using direct sequencing of genomic DNA and the multiplex ligation-dependent probe amplification, we identified twelve pathogenic Atm mutations, including one missense, four nonsense, five frameshift, one splicing, and one large genomic deletion. All the Atm mutations we identified were novel, and no homozygous mutation and founder-effect mutation were found. These results suggest that Atm mutations in Chinese populations are diverse and distinct largely from those in other ethnic areas.

  2. Oral papillary squamous cell carcinoma in twelve dogs.

    Science.gov (United States)

    Nemec, A; Murphy, B G; Jordan, R C; Kass, P H; Verstraete, F J M

    2014-01-01

    Papillary squamous cell carcinoma (PSCC) is a distinct histological subtype of oral squamous cell carcinoma (SCC), described in both dogs and man. In dogs, PSCC has long been considered a malignant oral tumour of very young animals, but it has recently been reported to occur in adult dogs as well. The aim of this study was to describe the major clinicopathological characteristics of canine oral PSCC (COPSCC). Twelve dogs diagnosed with COPSCC were included in this retrospective study (1990-2012). The majority (75%) of the dogs were >6 years of age (median age 9 years). All tumours were derived from the gingiva of dentate jaws, with 66.7% affecting the rostral aspects of the jaws. The gross appearance of the lesions varied, with one having an intraosseous component only. The majority (91.7%) of the tumours were advanced lesions (T2 and T3), but no local or distant metastases were noted. Microscopically, two patterns were seen: (1) invasion of bone forming a cup-shaped indentation in the bone or a deeply cavitating cyst within the bone (cavitating pattern), (2) histologically malignant growth, but lack of apparent bone invasion (non-cavitating pattern). The microscopical appearance corresponded to imaging findings in a majority of cases, with cavitating forms presenting with a cyst-like pattern of bone loss or an expansile mass on imaging and non-cavitating forms showing an infiltrative pattern of bone destruction on imaging. These features suggest two distinct biological behaviours of COPSCC.

  3. Sensitivity and growth of twelve Elatior begonia cultivars to ozone

    Energy Technology Data Exchange (ETDEWEB)

    Reinert, R.A.; Nelson, P.V.

    1979-12-01

    Twelve cultivars of Elatior begonia (Begonia X hiemalis Fotsch.) were exposed to O/sub 3/ at 25 and 50 pphM. The 'Schwabenland' group, 'Whisper 'O' Pink', and 'Improved Krefeld Orange' were the most sensitive, whereas 'Ballerina', 'Mikkell Limelight', and 'Turo' were the least sensitive. 'Rennaisance', 'Heirloom' 'Nixe', and 'Fantasy' were intermediate in sensitivity. The dry weight of foliage (stems plus leaves) of 9 cultivars exposed to O/sub 3/ was significantly less than that of control plants. Ozone at 25 and 50 pphM inhibited flower growth (including peduncles) and development in 4 and 8 of the 12 cultivars, respectively. Differences in flower weight ranged from 43 to 105% of the control at 25 pphM and from 25 to 98% of the control at 50 pphM, depending on cultivar. 1 table.

  4. Alcoholics anonymous and other twelve-step programs in recovery.

    Science.gov (United States)

    Detar, D Todd

    2011-03-01

    Recovery is a new way of life for many patients; a life without substances to alter their moods but with a major change improving the physical, psychological, and emotional stability with improved overall health outcomes. The Twelve Steps of the Alcoholics Anonymous (AA) are the foundation of the AA, describing both the necessary actions and the spiritual basis for the recovery program of the AA. The Twelve Steps of the AA provide a structure for which a patient with alcoholism may turn for an answer to their problem of alcohol use, abuse, or dependence. Copyright © 2011 Elsevier Inc. All rights reserved.

  5. The strong coupling regime of twelve flavors QCD

    NARCIS (Netherlands)

    Silva, Tiago Nunes da; Pallante, Elisabetta

    2012-01-01

    We summarize the results recently reported in Ref.[1] [A. Deuzeman, M.P. Lombardo, T. Nunes da Silva and E. Pallante,"The bulk transition of QCD with twelve flavors and the role of improvement"] for the SU(3) gauge theory with Nf=12 fundamental flavors, and we add some numerical evidence and theoret

  6. EFFORTS Technical annex for the twelve month progress report

    DEFF Research Database (Denmark)

    Andreasen, Jan Lasson; Eriksen, Morten; Thomas christensen, Thomas Vennick;

    The present report is documentation for the work carried out at DTU during the second year of project activity. The report describes the work completed by DTU in general as well as on the active sub-tasks within materials properties, friction modelling and physical modelling, over the last twelve...

  7. Human Evolution in Science Textbooks from Twelve Different Countries

    Science.gov (United States)

    Quessada, Marie-Pierre; Clement, Pierre; Oerke, Britta; Valente, Adriana

    2008-01-01

    What kinds of images of human beings illustrate human evolution in school textbooks? A comparison between the textbooks of eighteen different countries (twelve European countries and six non-European countries) was attempted. In six countries (Algeria, Malta, Morocco, Mozambique, Portugal, and Tunisia), we did not find any chapter on the topic of…

  8. Bibliography of Spanish Materials for Students, Grades Seven through Twelve.

    Science.gov (United States)

    California State Dept. of Education, Sacramento.

    This annotated bibliography of Spanish materials for students in grades seven through twelve is divided into the following categories: (1) Art, Drama, Music, and Poetry; (2) Books in Series; (3) Culture; (4) Dictionaries and Encyclopedias; (5) Literature; (6) Mathematics; (7) Physical Education, Health, and Recreation; (8) Reading and Language…

  9. Twelve Theses on Reactive Rules for the Web

    OpenAIRE

    Bry, François; Eckert, Michael

    2007-01-01

    Reactivity, the ability to detect and react to events, is an essential functionality in many information systems. In particular, Web systems such as online marketplaces, adaptive (e.g., recommender) sys- tems, and Web services, react to events such as Web page updates or data posted to a server. This article investigates issues of relevance in designing high-level programming languages dedicated to reactivity on the Web. It presents twelve theses on features desira...

  10. Premarital Sex in the Last Twelve Months and Its Predictors among Students of Wollega University, Ethiopia.

    Science.gov (United States)

    Regassa, Tesfaye; Chala, Dereje; Adeba, Emiru

    2016-07-01

    Premarital sex increases the risk of unintended pregnancy and sexually transmitted infections including HIV if unprotected and contraception is not used. Thus, the objective of this study was to assess premarital sex in the last twelve months and its predictors among regular undergraduate students of Wollega University. A cross-sectional survey using pretested, structured questionnaire was conducted on a total of 704 regular undergraduate students of Wollega University from February to March, 2014. We used multistage sampling technique to recruit study participants. Binary and multivariable logistic regressions were performed using SPSS version 20 to assess predictors of premarital sex. Statistical significance was determined through a 95% confidence level. Wollega University youths who had premarital sex in the last twelve months were 28.4%; 55.5% of them did not use condom during last sex while 31.3% engaged in multiple sex. Being male [Adjusted Odds Ratio (AOR)(95% Confidence Interval(CI))=2.7(1.58-4.75)], age 20-24 years [AOR(95%CI)=2.8(1.13-7.20)], training on how to use condom [AOR(95%CI)=1.7(1.17-2.46)], being tested for HIV [AOR(95%CI)=2.3(1.48-3.53)], using social media frequently [AOR(95%CI)=1.8(1.14-2.88)], having comprehensive knowledge of HIV [AOR(95% CI)=1.5(1.01-2.10)], alcohol use [AOR (95%CI)=2.2(1.31-3.56)] were associated with increased odds of premarital sex in the last twelve months. Nearly one-third of regular undergraduate students of the university were engaged in premarital sex in the last twelve months. Being male, using social media frequently and alcohol use were associated with increased odds of premarital sex in the stated period. Thus, higher institutions have to deliver abstinence messages alongside information about self-protection.

  11. The twelve theses: a call to a new reformation

    Directory of Open Access Journals (Sweden)

    John Shelby Spong

    2015-03-01

    Full Text Available With every discovery emerging from the world of science over the last 500 years concerning the origins of the universe and of life itself, the traditional explanations offered by the Christian Church appeared to be more and more dated and irrelevant.  Christian leaders, unable to embrace the knowledge revolution seemed to believe  that the only way to save Christianity was not to disturb the old patterns either by listening to, much less by entertaining the new knowledge. I tried to articulate this challenge in a book entitled: Why Christianity Must Change or Die, published in 1998.  In that book I examined in detail the issues that I was convinced Christianity must address. Shortly after that book was published I reduced its content to twelve theses, which I attached in Luther-like fashion to the great doors on the Chapel of Mansfield College at Oxford University in the United Kingdom. I then mailed copies of those Twelve Theses to every acknowledged Christian leader of the world. It was an attempt to call them into a debate on the real issues that I was certain the Christian Church now faced.  I framed my twelve theses in the boldest, most provocative language possible, designed primarily to elicit response and debate. I welcome responses from Christians everywhere.  I claim no expertise or certainty in developing answers, but I am quite confident that I do understand the problems we are facing as Christians who are seeking to relate to the 21st century.

  12. New Eyes on the Universe Twelve Cosmic Mysteries and the Tools We Need to Solve Them

    CERN Document Server

    Webb, Stephen

    2012-01-01

    "New Eyes on the Universe -- Twelve Cosmic Mysteries and the Tools We Need to Solve Them" gives an up-to-date broad overview of some of the key issues in modern astronomy and cosmology. It describes the vast amount of observational data that the new generation of observatories and telescopes are currently producing, and how that data might solve some of the outstanding puzzles inherent in our emerging world view. Included are questions such as: What is causing the Universe to blow itself apart? What could be powering the luminous gamma-ray bursters? Where is all the matter in the Uni

  13. DETECTION OF CHROMOSOME ABERRATIONS IN TWELVE PRIMARY GASTRIC CANCERS BY DIRECT CHROMOSOME ANALYSIS AND FISH

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Direct chromosome analysis and FISH were performed on twelve primary gastric carcinomas. Two of them had simple chromosome changes: 48,XX, +8, +20, and 49, XY, +2, +8, +9, and the others had complicated chromosome changes, which includes much more numerical and structural chromosome aberrations. Frequent structural changes in the complicated types involved chromosome 7, 3, 1, 5 and 12 etc. The del 7q was noted in eight cases. The del (3p) and del (1p) were noted in six and five cases, respectively. The results provide some important clues for isolation of the genes related to gastric cancer.

  14. Twelve tips for teaching medical students with dyslexia.

    Science.gov (United States)

    Shaw, Sebastian Charles Keith; Anderson, John Leeds

    2017-07-01

    Dyslexia is a common learning difficulty. As a result of SS' own experiences as a medical student with dyslexia, we have been researching and teaching on this topic for the past two years. Here, we present twelve tips for teaching medical students with dyslexia. These are gathered from our personal experiences and research, discussions with other educators, and wider literature on the topic. This article aims to shed some light on dyslexia, and also to make practical suggestions. Teaching students with dyslexia should not be a daunting experience. Small changes to existing methods, at minor effort, can make a difference - for example, adding pastel colors to slide backgrounds or avoiding Serif fonts. These tips can help educators gain more insight into dyslexia and incorporate small, beneficial adaptations into their teaching.

  15. Antibacterial activities of extracts from twelve Centaurea species from Turkey

    Directory of Open Access Journals (Sweden)

    Tekeli Yener

    2011-01-01

    Full Text Available Members of the genus Centaurea (Asteraceae have been used in traditional plant-based medicine. The methanol extracts of twelve Centaurea species, of which five are endemic to Turkey flora, were screened for antibacterial activity against four bacteria (Escherichia coli, Bacillus cereus, Salmonella enteritidis, Staphylococcus aureus. The antibacterial activity was evaluated by the microdilution method and the minimum inhibition concentrations (MIC of the extracts were determined. C. cariensis subsp. microlepis exhibited an antimicrobial effect on all tested microorganisms. The extracts from eight Centaurea species (C. balsamita, C. calolepis, C. cariensis subsp. maculiceps, C. cariensis subsp. microlepis, C. kotschyi var. kotschyi, C. solstitialis subsp. solstitialis, C. urvillei subsp. urvillei and C. virgata possessed antibacterial activity against several of the tested microorganisms.

  16. Twelve tips on how to compile a medical educator's portfolio.

    Science.gov (United States)

    Dalton, Claudia Lucy; Wilson, Anthony; Agius, Steven

    2017-09-17

    Medical education is an expanding area of specialist interest for medical professionals. Whilst most doctors will be familiar with the compilation of clinical portfolios for scrutiny of their clinical practice and provision of public accountability, teaching portfolios used specifically to gather and demonstrate medical education activity remain uncommon in many non-academic settings. For aspiring and early career medical educators in particular, their value should not be underestimated. Such a medical educator's portfolio (MEP) is a unique compendium of evidence that is invaluable for appraisal, revalidation, and promotion. It can stimulate and provide direction for professional development, and is a rich source for personal reflection and learning. We recommend that all new and aspiring medical educators prepare an MEP, and suggest twelve tips on how to skillfully compile one.

  17. Twelve tips for designing and running longitudinal integrated clerkships.

    Science.gov (United States)

    Ellaway, Rachel; Graves, Lisa; Berry, Sue; Myhre, Doug; Cummings, Beth-Ann; Konkin, Jill

    2013-12-01

    Longitudinal integrated clerkships (LICs) involve learners spending an extended time in a clinical setting (or a variety of interlinked clinical settings) where their clinical learning opportunities are interwoven through continuities of patient contact and care, continuities of assessment and supervision, and continuities of clinical and cultural learning. Our twelve tips are grounded in the lived experiences of designing, implementing, maintaining, and evaluating LICs, and in the extant literature on LICs. We consider: general issues (anticipated benefits and challenges associated with starting and running an LIC); logistical issues (how long each longitudinal experience should last, where it will take place, the number of learners who can be accommodated); and integration issues (how the LIC interfaces with the rest of the program, and the need for evaluation that aligns with the dynamics of the LIC model). Although this paper is primarily aimed at those who are considering setting up an LIC in their own institutions or who are already running an LIC we also offer our recommendations as a reflection on the broader dynamics of medical education and on the priorities and issues we all face in designing and running educational programs.

  18. Commercializing Government-sponsored Innovations: Twelve Successful Buildings Case Studies

    Science.gov (United States)

    Brown, M. A.; Berry, L. G.; Goel, R. K.

    1989-01-01

    This report examines the commercialization and use of R and D results funded by DOE's Office of Buildings and Community Systems (OBCS), an office that is dedicated to improving the energy efficiency of the nation's buildings. Three goals guided the research described in this report: to improve understanding of the factors that hinder or facilitate the transfer of OBCS R and D results, to determine which technology transfer strategies are most effective and under what circumstances each is appropriate, and to document the market penetration and energy savings achieved by successfully-commercialized innovations that have received OBCS support. Twelve successfully-commercialized innovations are discussed here. The methodology employed involved a review of the literature, interviews with innovation program managers and industry personnel, and data collection from secondary sources. Six generic technology transfer strategies are also described. Of these, contracting R and D to industrial partners is found to be the most commonly used strategy in our case studies. The market penetration achieved to date by the innovations studied ranges from less than 1% to 100%. For the three innovations with the highest predicted levels of energy savings (i.e., the flame retention head oil burner, low-E windows, and solid-state ballasts), combined cumulative savings by the year 2000 are likely to approach 2 quads. To date the energy savings for these three innovations have been about 0.2 quads. Our case studies illustrate the important role federal agencies can play in commercializing new technologies.

  19. The strong coupling regime of twelve flavors QCD

    CERN Document Server

    da Silva, Tiago Nunes

    2012-01-01

    We summarize the results recently reported in Ref.[1] [A. Deuzeman, M.P. Lombardo, T. Nunes da Silva and E. Pallante,"The bulk transition of QCD with twelve flavors and the role of improvement"] for the SU(3) gauge theory with Nf=12 fundamental flavors, and we add some numerical evidence and theoretical discussion. In particular, we study the nature of the bulk transition that separates a chirally broken phase at strong coupling from a chirally restored phase at weak coupling. When a non-improved action is used, a rapid crossover is observed at small bare quark masses. Our results confirm a first order nature for this transition, in agreement with previous results we obtained using an improved action. As shown in Ref.[1], when improvement of the action is used, the transition is preceded by a second rapid crossover at weaker coupling and an exotic phase emerges, where chiral symmetry is not yet broken. This can be explained [1] by the non hermiticity of the improved lattice Transfer matrix, arising from the c...

  20. Twelve Years of Education and Public Outreach with the Fermi Gamma-ray Space Telescope

    CERN Document Server

    Cominsky, Lynn; Simonnet, Aurore; Education, the Fermi

    2013-01-01

    During the past twelve years, NASA's Fermi Gamma-ray Space Telescope has supported a wide range of Education and Public Outreach (E/PO) activities, targeting K-14 students and the general public. The purpose of the Fermi E/PO program is to increase student and public understanding of the science of the high-energy Universe, through inspiring, engaging and educational activities linked to the mission's science objectives. The E/PO program has additional more general goals, including increasing the diversity of students in the Science, Technology, Engineering and Mathematics (STEM) pipeline, and increasing public awareness and understanding of Fermi science and technology. Fermi's multi-faceted E/PO program includes elements in each major outcome category: Higher Education; Elementary and Secondary Education; Informal Education and Public Outreach.

  1. The Synthesis and Antitumor Activity of Twelve Galloyl Glucosides

    Directory of Open Access Journals (Sweden)

    Chang-Wei Li

    2015-01-01

    Full Text Available Twelve galloyl glucosides 1–12, showing diverse substitution patterns with two or three galloyl groups, were synthesized using commercially available, low-cost D-glucose and gallic acid as starting materials. Among them, three compounds, methyl 3,6-di-O-galloyl-α-D-glucopyranoside (9, ethyl 2,3-di-O-galloyl-α-D-glucopyranoside (11 and ethyl 2,3-di-O-galloyl-β-D-glucopyranoside (12, are new compounds and other six, 1,6-di-O-galloyl-β-D-glucopyranose (1, 1,4,6-tri-O-galloyl-β-D-glucopyranose (2, 1,2-di-O-galloyl-β-D-glucopyranose (3, 1,3-di-O-galloyl-β-D-glucopyranose (4, 1,2,3-tri-O-galloyl-α-D-glucopyranose (6 and methyl 3,4,6-tri-O-galloyl-α-D-glucopyranoside (10, were synthesized for the first time in the present study. In in vitro MTT assay, 1–12 inhibited human cancer K562, HL-60 and HeLa cells with inhibition rates ranging from 64.2% to 92.9% at 100 μg/mL, and their IC50 values were determined to be varied in 17.2–124.7 μM on the tested three human cancer cell lines. In addition, compounds 1–12 inhibited murine sarcoma S180 cells with inhibition rates ranging from 38.7% to 52.8% at 100 μg/mL in the in vitro MTT assay, and in vivo antitumor activity of 1 and 2 was also detected in murine sarcoma S180 tumor-bearing Kunming mice using taxol as positive control.

  2. [Twelve years of working of Brazzaville cancer registry].

    Science.gov (United States)

    Nsondé Malanda, Judith; Nkoua Mbon, Jean Bernard; Bambara, Augustin Tozoula; Ibara, Gérard; Minga, Benoît; Nkoua Epala, Brice; Gombé Mbalawa, Charles

    2013-02-01

    The Brazzaville cancer registry was created in 1996 with the support of the International Agency Research against Cancer (IARC) which is located in Lyon, France. The Brazzaville cancer registry is a registry which is based on population which records new cancer cases occurring in Brazzaville by using Canreg 4.0 Software. Its aim is to supply useful information to fight against cancer to physicians and to decision makers. We conducted this study whose target was to determine the incidence of cancer in Brazzaville during twelve years, from January 1st, 1998 to December 31, 2009. During that period 6,048 new cancer cases were recorded: 3,377 women (55.8%), 2,384 men (39.4%), and 287 children (4.8%) from 0 to 14 years old with an annual average of 504 cases. Middle age to the patient's diagnosis was 49.5 years in female sex and 505.5 years old for male sex. The incidence rate of cancers in Brazzaville was 39.8 or 100.000 inhabitants per year and by sex we observed 49 to female sex and 35.2 for male sex. The first cancers localizations observed to women were in order of frequency: breast, cervix uterine, liver ovaries, hematopoietic system, to men : liver, prostate, hematopoietic system, colon and stomach; to children : retina, kidney, hematopoietic system, liver and bones. These rates are the basis to know the burden of cancer among all pathologies of Brazzaville and the achievement of a national cancer control program.

  3. Hyperinsulinism and hyperammonemia syndrome: report of twelve unrelated patients.

    Science.gov (United States)

    De Lonlay, P; Benelli, C; Fouque, F; Ganguly, A; Aral, B; Dionisi-Vici, C; Touati, G; Heinrichs, C; Rabier, D; Kamoun, P; Robert, J J; Stanley, C; Saudubray, J M

    2001-09-01

    Hyperinsulinism and hyperammonemia syndrome has been reported as a cause of moderately severe hyperinsulinism with diffuse involvement of the pancreas. The disorder is caused by gain of function mutations in the GLUD1 gene, resulting in a decreased inhibitory effect of guanosine triphosphate on the glutamate dehydrogenase (GDH) enzyme. Twelve unrelated patients (six males, six females) with hyperinsulinism and hyperammonemia syndrome have been investigated. The phenotypes were clinically heterogeneous, with neonatal and infancy-onset hypoglycemia and variable responsiveness to medical (diazoxide) and dietary (leucine-restricted diet) treatment. Hyperammonemia (90-200 micromol/L, normal carbamylglutamate administration. The patients had mean basal GDH activity (18.3 +/- 0.9 nmol/min/mg protein) not different from controls (17.9 +/- 1.8 nmol/min/mg protein) in cultured lymphoblasts. The sensitivity of GDH activity to inhibition by guanosine triphosphate was reduced in all patient lymphoblast cultures (IC(50), or concentrations required for 50% inhibition of GDH activity, ranging from 140 to 580 nM, compared with control IC(50) value of 83 +/- 1.0 nmol/L). The allosteric effect of ADP was within the normal range. The activating effect of leucine on GDH activity varied among the patients, with a significant decrease of sensitivity that was correlated with the negative clinical response to a leucine-restricted diet in plasma glucose levels in four patients. Molecular studies were performed in 11 patients. Heterozygous mutations were localized in the antenna region (four patients in exon 11, two patients in exon 12) as well as in the guanosine triphosphate binding site (two patients in exon 6, two patients in exon 7) of the GLUD1 gene. No mutation has been found in one patient after sequencing the exons 5-13 of the gene.

  4. Commercializing government-sponsored innovations: Twelve successful buildings case studies

    Energy Technology Data Exchange (ETDEWEB)

    Brown, M.A.; Berry, L.G.; Goel, R.K.

    1989-01-01

    This report examines the commercialization and use of R and D results funded by DOE's Office of Buildings and Community Systems (OBCS), an office that is dedicated to improving the energy efficiency of the nation's buildings. Three goals guided the research described in this report: to improve understanding of the factors that hinder or facilitate the transfer of OBCS R and D results, to determine which technology transfer strategies are most effective and under what circumstances each is appropriate, and to document the market penetration and energy savings achieved by successfully-commercialized innovations that have received OBCS support. Twelve successfully-commercialized innovations are discussed here. The methodology employed involved a review of the literature, interviews with innovation program managers and industry personnel, and data collection from secondary sources. Six generic technology transfer strategies are also described. Of these, contracting R and D to industrial partners is found to be the most commonly used strategy in our case studies. The market penetration achieved to date by the innovations studied ranges from less than 1% to 100%. For the three innovations with the highest predicted levels of energy savings (i.e., the flame retention head oil burner, low-E windows, and solid-state ballasts), combined cumulative savings by the year 2000 are likely to approach 2 quads. To date the energy savings for these three innovations have been about 0.2 quads. Our case studies illustrate the important role federal agencies can play in commercializing new technologies. 27 refs., 21 figs., 4 tabs.

  5. Development and characterization of twelve microsatellite markers for Porphyra linearis Greville.

    Science.gov (United States)

    Varela-Álvarez, Elena; Paulino, Cristina; Serrão, Ester A

    2017-02-01

    The genus Porphyra (and its sister genus Pyropia) contains important red algal species that are cultivated and/or harvested for human consumption, sustaining a billion-dollar aquaculture industry. A vast amount of research has been focused on species of this genus, including studies on genetics and genomics among other areas. Twelve novel microsatellite markers were developed here for Porphyra linearis. Markers were characterized using 32 individuals collected from four natural populations of P. linearis with total heterozygosity varying from 0.098 to 0.916. The number of alleles per locus ranged from 2 to 18. All markers showed cross amplification with Porphyra umbilicalis and/or Porphyra dioica. These polymorphic microsatellite markers are useful for investigating population genetic diversity and differentiation in P. linearis and may become useful for other genetic research on the reproductive biology of this important species.

  6. Twelve tips for developing and delivering a massive open online course in medical education.

    Science.gov (United States)

    Pickering, James D; Henningsohn, Lars; DeRuiter, Marco C; de Jong, Peter G M; Reinders, Marlies E J

    2017-07-01

    Massive open online courses (MOOCs) are a novel mode of online learning. They are typically based on higher education courses and can attract a high number of learners, often in the thousands. They are distinct from on-campus education and deliver the learning objectives through a series of short videos, recommended readings and discussion fora, alongside automated assessments. Within medical education the role of MOOCs remains unclear, with recent proposals including continuing professional development, interprofessional education or integration into campus-based blended learning curricula. In this twelve tips article, we aim to provide a framework for readers to use when developing, delivering and evaluating a MOOC within medical education based on the literature and our own experience. Practical advice is provided on how to design the appropriate curriculum, engage with learners on the platform, select suitable assessments, and comprehensively evaluate the impact of your course.

  7. Hepatoprotective activity of twelve novel 7'-hydroxy lignan glucosides from Arctii Fructus.

    Science.gov (United States)

    Yang, Ya-Nan; Huang, Xiao-Ying; Feng, Zi-Ming; Jiang, Jian-Shuang; Zhang, Pei-Cheng

    2014-09-17

    Twelve novel 7'-hydroxy lignan glucosides (1-12), including two benzofuran-type neolignans, two 8-O-4' neolignans, two dibenzylbutyrolactone lignans, and six tetrahydrofuranoid lignans, together with six known lignan glucosides (13-18), were isolated from the fruit of Arctium lappa L. (Asteraceae), commonly known as Arctii Fructus. Their structures were elucidated using spectroscopy (1D and 2D NMR, MS, IR, ORD, and UV) and on the basis of chemical evidence. The absolute configurations of compounds 1-12 were confirmed using rotating frame nuclear overhauser effect spectroscopy (ROESY), the circular dichroic (CD) exciton chirality method, and Rh2(OCOCF3)4-induced CD spectrum analysis. All of the isolated compounds were tested for hepatoprotective effects against D-galactosamine-induced cytotoxicity in HL-7702 hepatic cells. Compounds 1, 2, 7-12, and 17 showed significantly stronger hepatoprotective activity than the positive control bicyclol at a concentration of 1 × 10(-5) M.

  8. An Experiment in Humanistic Management within Community College District Twelve, Centralia/Olympia, Washington.

    Science.gov (United States)

    Miller, Dale A.; Hurley, John A.

    Community College District Twelve, a multi-college district serving a two-county area in southwestern Washington, has attempted to incorporate at administrative levels many of the humanistic, process-oriented principles of management discussed by Maslow and Maccoby. A concept of the ideal leadership style for District Twelve guides the selection…

  9. The impact of alcoholics anonymous on other substance abuse-related twelve-step programs.

    Science.gov (United States)

    Laudet, Alexandre B

    2008-01-01

    This chapter explores the influence of the AA model on self-help fellowships addressing problems of drug dependence. Fellowships that have adapted the twelve-step recovery model to other substances of abuse are reviewed; next similarities and differences between AA and drug-recovery twelve-step organizations are examined; finally, we present empirical findings on patterns of attendance and perceptions of AA and Narcotics Anonymous (NA) among polydrug-dependent populations, many of whom are cross-addicted to alcohol. Future directions in twelve-step research are noted in closing.

  10. Scarcity and Survival in El Salvador. Grades Six to Twelve.

    Science.gov (United States)

    Stanford Univ., CA. Stanford Program on International and Cross Cultural Education.

    This unit, designed for use with students in grades 6-12, has two purposes: (1) to inform teachers and students about social and economic conditions in rural El Salvador; and (2) to teach students how to analyze the indicators of such social and economic conditions. The six included lessons incorporate reading, graphing, and critical thinking…

  11. Twelve Years of Telecollaboration: What We Have Learnt

    Science.gov (United States)

    Sadler, Randall; Dooly, Melinda

    2016-01-01

    This article describes the evolution, over a 12-year period, of a telecollaborative project between two universities. The project focused on two teacher training courses that integrate in-class dialogic learning and flipped classroom materials. The authors begin by outlining the first years of the project, including an overview of the initial…

  12. Twelve tips for creating trigger images for problem-based learning cases.

    Science.gov (United States)

    Azer, Samy A

    2007-03-01

    A trigger is the starting point of problem-based learning (PBL) cases. It is usually in the form of 5-6 text lines that provide the key information about the main character (usually the patient), including 3-4 of patient's presenting problems. In addition to the trigger text, most programs using PBL include a visual trigger. This might be in the form of a single image, a series of images, a video clip, a cartoon, or even one of the patient's investigation results (e.g. chest X-ray, pathology report, or urine sample analysis). The main educational objectives of the trigger image are as follows: (1) to introduce the patient to the students; (2) to enhance students' observation skills; (3) to provide them with new information to add to the cues obtained from the trigger text; and (4) to stimulate students to ask questions as they develop their enquiry plan. When planned and delivered effectively, trigger images should be engaging and stimulate group discussion. Understanding the educational objectives of using trigger images and choosing appropriate images are the keys for constructing successful PBL cases. These twelve tips highlight the key steps in the successful creation of trigger images.

  13. CLINICAL APPLICATION OF “TWELVE WELL-POINTS” IN EMERGENCY TREATMENT

    Institute of Scientific and Technical Information of China (English)

    段功保

    2000-01-01

    In many years' clinical practice, I used blood-letting method of “Twelve Well-points” to treat emergencies as coma, syncope, acute infantile convulsion, wind-stroke syndrome, hysteria, epilepsy, etc. and have achieved immediate results.

  14. The myrmicine ant genus Metapone Forel (Hymenoptera: Formicidae): a global taxonomic review with descriptions of twelve new species.

    Science.gov (United States)

    Taylor, Robert W; Alpert, Gary D

    2016-04-26

    The 28 known species of Metapone are monographed and illustrated. Twelve are described as new: M. africana, Gabon; M. balinensis, Bali, Indonesia; M. enigmatica, northeast New Guinea; M. hoelldobleri, northeast Queensland, Australia; M. javana, Java, Indonesia; M. manni, Viti Levu, Fiji; M. mathinnae, Flinders Island, Tasmania, Australia; M. philwardi, northeast New Guinea; M. salomonis, Guadalcanal, Solomon Islands; M. tecklini, northeast Queensland; M. titan, New Ireland, Papua New Guinea; M. wallaceana, Lombok, Indonesia; spp.n. New synonymies include M. greeni Forel = M. johni Karavaiev (Sri Lanka) syn.n, and M. jacobsoni Crawley (Sumatra) = M. nicobarensis Tiwari & Jonathan (Great Nicobar Island) syn.n.

  15. Twelve tips for constructing problem-based learning cases.

    Science.gov (United States)

    Azer, Samy A; Peterson, Ray; Guerrero, Anthony P S; Edgren, Gudrun

    2012-01-01

    One of the key elements for introducing a problem-based learning (PBL) programme is constructing good PBL cases. Good cases should reflect the educational principles of PBL including (a) integration of basic and clinical sciences together with professionalism and psychosocial components, (b) encouragement of discussion of cognitive domains such as identification of problems, generation of hypotheses, construction of an enquiry plan, weighing evidence for and against each hypothesis, interpretation of findings, construction of mechanisms, using evidence to refine the hypothesis and construction of a management plan, (c) encouragement of discussion of cases in small groups with an emphasis on student-centred learning, (d) promotion of collaborative learning and contribution of students to the case discussion and (e) encouragement of teamwork and self-directed learning strategies. Despite the importance of construction of good PBL cases to the success of a PBL programme, the art of construction of these cases is understudied or described in the literature. Based on our experience in PBL and evidence from literature, we described 12 tips for constructing good PBL cases. Constructing good PBL cases is an art that necessitates teamwork and input from several different disciplines. Cases should be constructed using a template reflecting the educational objectives of the programme. This approach will ensure optimum learning outcomes and consistency in the design and delivery of cases.

  16. TRANSIT TIMING OBSERVATIONS FROM KEPLER. VIII. CATALOG OF TRANSIT TIMING MEASUREMENTS OF THE FIRST TWELVE QUARTERS

    Energy Technology Data Exchange (ETDEWEB)

    Mazeh, Tsevi; Nachmani, Gil; Holczer, Tomer; Sokol, Gil [School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978 (Israel); Fabrycky, Daniel C. [Department of Astronomy and Astrophysics, University of Chicago, 5640 Ellis Ave., Chicago, IL 60637 (United States); Ford, Eric B.; Ragozzine, Darin [Astronomy Department, University of Florida, Gainesville, FL 32111 (United States); Sanchis-Ojeda, Roberto [Department of Physics and Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Rowe, Jason F.; Lissauer, Jack J. [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Zucker, Shay [Department of Geophysical, Atmospheric and Planetary Sciences, Raymond and Beverly Sackler Faculty of Exact Sciences Tel Aviv University, 69978 Tel Aviv (Israel); Agol, Eric [Department of Astronomy, Box 351580, University of Washington, Seattle, WA 98195 (United States); Carter, Joshua A. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Quintana, Elisa V. [SETI Institute, 189 Bernardo Ave, Suite 100, Mountain View, CA 94043 (United States); Steffen, Jason H. [Fermilab Center for Particle Astrophysics, P.O. Box 500, MS 127, Batavia, IL 60510 (United States); Welsh, William [Astronomy Department, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 (United States)

    2013-10-01

    Following the works of Ford et al. and Steffen et al. we derived the transit timing of 1960 Kepler objects of interest (KOIs) using the pre-search data conditioning light curves of the first twelve quarters of the Kepler data. For 721 KOIs with large enough signal-to-noise ratios, we obtained also the duration and depth of each transit. The results are presented as a catalog for the community to use. We derived a few statistics of our results that could be used to indicate significant variations. Including systems found by previous works, we have found 130 KOIs that showed highly significant times of transit variations (TTVs) and 13 that had short-period TTV modulations with small amplitudes. We consider two effects that could cause apparent periodic TTV—the finite sampling of the observations and the interference with the stellar activity, stellar spots in particular. We briefly discuss some statistical aspects of our detected TTVs. We show that the TTV period is correlated with the orbital period of the planet and with the TTV amplitude.

  17. Peer teaching in medical education: twelve reasons to move from theory to practice.

    Science.gov (United States)

    Ten Cate, Olle; Durning, Steven

    2007-09-01

    To provide an estimation of how often peer teaching is applied in medical education, based on reports in the literature and to summarize reasons that support the use of this form of teaching. We surveyed the 2006 medical education literature and categorised reports of peer teaching according to educational distance between students teaching and students taught, group size, and level of formality of the teaching. Subsequently, we analysed the rationales for applying peer teaching. Most reports were published abstracts in either Medical Education's annual feature 'Really Good Stuff' or the AMEE's annual conference proceedings. We identified twelve distinct reasons to apply peer teaching, including 'alleviating faculty teaching burden', 'providing role models for junior students', 'enhancing intrinsic motivation' and 'preparing physicians for their future role as educators'. Peer teaching appears to be practiced often, but many peer teaching reports do not become full length journal articles. We conclude that specifically 'near-peer teaching' appears beneficial for student teachers and learners as well as for the organisation. The analogy of the 'journeyman', as intermediate between 'apprentice' and 'master', with both learning and teaching tasks, is a valuable but yet under-recognized source of education in the medical education continuum.

  18. Whole-Proteome Analysis of Twelve Species of Alphaproteobacteria Links Four Pathogens

    Directory of Open Access Journals (Sweden)

    Yunyun Zhou

    2013-11-01

    Full Text Available Thousands of whole-genome and whole-proteome sequences have been made available through advances in sequencing technology, and sequences of millions more organisms will become available in the coming years. This wealth of genetic information will provide numerous opportunities to enhance our understanding of these organisms including a greater understanding of relationships among species. Researchers have used 16S rRNA and other gene sequences to study the evolutionary origins of bacteria, but these strategies do not provide insight into the sharing of genes among bacteria via horizontal transfer. In this work we use an open source software program called pClust to cluster proteins from the complete proteomes of twelve species of Alphaproteobacteria and generate a dendrogram from the resulting orthologous protein clusters. We compare the results with dendrograms constructed using the 16S rRNA gene and multiple sequence alignment of seven housekeeping genes. Analysis of the whole proteomes of these pathogens grouped Rickettsia typhi with three other animal pathogens whereas conventional sequence analysis failed to group these pathogens together. We conclude that whole-proteome analysis can give insight into relationships among species beyond their phylogeny, perhaps reflecting the effects of horizontal gene transfer and potentially providing insight into the functions of shared genes by means of shared phenotypes.

  19. INCIDENCE AND SURVIVAL OF LIPOLYTIC ORGANISMS MONITORED FOR TWELVE MONTHS IN DOMESTIC WASTEWATER AND RECEIVING STREAM

    Directory of Open Access Journals (Sweden)

    Adebowale Odeyemi

    2013-10-01

    Full Text Available The incidence and survival of lipolytic organisms in domestic wastewater and receiving stream were monitored over 12 months. The average total bacterial count in the wastewater samples reduced in April and November by 24.2% and 41.6% respectively. There was also a reduction of 42.3% and 60.1% in the load in the receiving stream in August and July. Subsequently, at 5m downstream from the entry of the wastewater the microbial load reduced in March (19.2% and June (19.2%. However, the occurrence of coliforms was more affected in the months of May (53% to July (87.2%. At 5m and 10m downstream the coliform population reduced by 27.9% and 30.1% respectively. Of the twelve (12 bacterial isolates obtained at the exit of the wastewater into the receiving stream, only four (4 were found to possess lipolytic activity. These include the species of Enterococcus, Klebsiella, Pseudomonas and Staphylococcus. There was no significant difference in the amount of nutrients found in the domestic wastewater and receiving stream during the months. This paper also discusses the implication of disposing large amounts of wastewater effluents into the receiving water and the need to remedy and minimize the overall impact of such pollution on the environment.

  20. Differences in antimicrobial activity of chlorine against twelve most prevalent poultry-associated Salmonella serotypes.

    Science.gov (United States)

    Paul, Narayan C; Sullivan, Tarah S; Shah, Devendra H

    2017-06-01

    Chlorine is the most widely used carcass sanitizer in poultry processing in the USA. The objective of this study was to determine the effects of varying concentrations of organic matter on the susceptibility of twelve most prevalent poultry-associated Salmonella serotypes (MPPSTs) to chlorine. To mimic the microenvironment of the water used for immersion chilling, we manipulated organic matter contamination levels in pre-chilled (pH∼6, T∼4 °C) chlorinated (50 ppm) water using varying concentrations (0, 1, 2, 3, 4, and 5%) of chicken-meat-extract (CME) produced from frozen chicken carcasses. This CME-based in vitro model was challenged with ∼1 × 10(5) CFUs of each MPPST isolate and the bacterial survival was tested at 5, 30, 60 and 90 min post-challenge. In this model, the decimal reduction time (D90-values) of each MPPST was linearly correlated with the concentration of CME. Significant inter-serotype differences in the D90-values were observed. The results show that the pH, concentration of total- and free-chlorine were also linearly correlated with the presence of CME in a concentration-dependent manner. The findings of this study indicate that the serotype and the levels of organic matter contamination significantly influence Salmonella survival and that both variables should be included in models that predict effectiveness of chlorine treatment in immersion chilling.

  1. Electricity production from twelve monosaccharides using microbial fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Catal, Tunc [Department of Biological and Ecological Engineering, Oregon State University, 116 Gilmore Hall, Corvallis, OR 97331 (United States); Department of Wood Science and Engineering, Oregon State University, 102 Richardson Hall, Corvallis, OR 97331 (United States); Department of Molecular Biology and Genetics, Istanbul Technical University, 34469-Maslak, Istanbul (Turkey); Li, Kaichang [Department of Wood Science and Engineering, Oregon State University, 102 Richardson Hall, Corvallis, OR 97331 (United States); Bermek, Hakan [Department of Molecular Biology and Genetics, Istanbul Technical University, 34469-Maslak, Istanbul (Turkey); Liu, Hong [Department of Biological and Ecological Engineering, Oregon State University, 116 Gilmore Hall, Corvallis, OR 97331 (United States)

    2008-01-03

    Direct generation of electricity from monosaccharides of lignocellulosic biomass was examined using air cathode microbial fuel cells (MFCs). Electricity was generated from all carbon sources tested, including six hexoses (D-glucose, D-galactose, D(-)-levulose (fructose), L-fucose, L-rhamnose, and D-mannose), three pentoses (D-xylose, D(-)-arabinose, and D(-)-ribose), two uronic acids (D-galacturonic acid and D-glucuronic acid) and one aldonic acid (D-gluconic acid). The mixed bacterial culture, which was enriched using acetate as a carbon source, adapted well to all carbon sources tested, although the adaptation times varied from 1 to 70 h. The maximum power density obtained from these carbon sources ranged from 1240 {+-} 10 to 2770 {+-} 30 mW m{sup -2} at current density range of 0.76-1.18 mA cm{sup -2}. D-Mannose resulted in the lowest maximum power density, whereas D-glucuronic acid generated the highest one. Coulombic efficiency ranged from 21 to 37%. For all carbon sources tested, the relationship between the maximum voltage output and the substrate concentration appeared to follow saturation kinetics at 120 {omega} external resistance. The estimated maximum voltage output ranged between 0.26 and 0.44 V and half-saturation kinetic constants ranged from 111 to 725 mg L{sup -1}. Chemical oxygen demand (COD) removal was over 80% for all carbon sources tested. Results from this study indicated that lignocellulosic biomass-derived monosaccharides might be a suitable resource for electricity generation using MFC technology. (author)

  2. Electricity production from twelve monosaccharides using microbial fuel cells

    Science.gov (United States)

    Catal, Tunc; Li, Kaichang; Bermek, Hakan; Liu, Hong

    Direct generation of electricity from monosaccharides of lignocellulosic biomass was examined using air cathode microbial fuel cells (MFCs). Electricity was generated from all carbon sources tested, including six hexoses (D-glucose, D-galactose, D(-)-levulose (fructose), L-fucose, L-rhamnose, and D-mannose), three pentoses (D-xylose, D(-)-arabinose, and D(-)-ribose), two uronic acids (D-galacturonic acid and D-glucuronic acid) and one aldonic acid (D-gluconic acid). The mixed bacterial culture, which was enriched using acetate as a carbon source, adapted well to all carbon sources tested, although the adaptation times varied from 1 to 70 h. The maximum power density obtained from these carbon sources ranged from 1240 ± 10 to 2770 ± 30 mW m -2 at current density range of 0.76-1.18 mA cm -2. D-Mannose resulted in the lowest maximum power density, whereas D-glucuronic acid generated the highest one. Coulombic efficiency ranged from 21 to 37%. For all carbon sources tested, the relationship between the maximum voltage output and the substrate concentration appeared to follow saturation kinetics at 120 Ω external resistance. The estimated maximum voltage output ranged between 0.26 and 0.44 V and half-saturation kinetic constants ranged from 111 to 725 mg L -1. Chemical oxygen demand (COD) removal was over 80% for all carbon sources tested. Results from this study indicated that lignocellulosic biomass-derived monosaccharides might be a suitable resource for electricity generation using MFC technology.

  3. Twelve Years of Education and Public Outreach with the Fermi Gamma-ray Space Telescope

    Science.gov (United States)

    Cominsky, Lynn R.; McLin, K. M.; Simonnet, A.; Fermi E/PO Team

    2013-04-01

    During the past twelve years, NASA's Fermi Gamma-ray Space Telescope has supported a wide range of Education and Public Outreach (E/PO) activities, targeting K-14 students and the general public. The purpose of the Fermi E/PO program is to increase student and public understanding of the science of the high-energy Universe, through inspiring, engaging and educational activities linked to the mission’s science objectives. The E/PO program has additional more general goals, including increasing the diversity of students in the Science, Technology, Engineering and Mathematics (STEM) pipeline, and increasing public awareness and understanding of Fermi science and technology. Fermi's multi-faceted E/PO program includes elements in each major outcome category: ● Higher Education: Fermi E/PO promotes STEM careers through the use of NASA data including research experiences for students and teachers (Global Telescope Network), education through STEM curriculum development projects (Cosmology curriculum) and through enrichment activities (Large Area Telescope simulator). ● Elementary and Secondary education: Fermi E/PO links the science objectives of the Fermi mission to well-tested, customer-focused and NASA-approved standards-aligned classroom materials (Black Hole Resources, Active Galaxy Education Unit and Pop-up book, TOPS guides, Supernova Education Unit). These materials have been distributed through (Educator Ambassador and on-line) teacher training workshops and through programs involving under-represented students (after-school clubs and Astro 4 Girls). ● Informal education and public outreach: Fermi E/PO engages the public in sharing the experience of exploration and discovery through high-leverage multi-media experiences (Black Holes planetarium and PBS NOVA shows), through popular websites (Gamma-ray Burst Skymap, Epo's Chronicles), social media (Facebook, MySpace), interactive web-based activities (Space Mysteries, Einstein@Home) and activities by

  4. Ocular hypotensive effect, preservation of visual fields, and safety of adding dorzolamide to prostaglandin therapy for twelve months

    Directory of Open Access Journals (Sweden)

    Kenji Inoue

    2011-03-01

    Full Text Available Kenji Inoue1,3, Mieko Masumoto1,3, Masato Wakakura1, Goji Tomita2, On behalf of the Ochanomizu Ophthalmology Study Group31Inouye Eye Hospital, Tokyo, Japan; 2Department of Ophthalmology, Toho University School of Medicine, Tokyo, Japan; 3Ochanomizu Ophthalmology, Tokyo, JapanPurpose: To prospectively evaluate the safety, hypotensive effect, and preservation of visual fields of dorzolamide when added to latanoprost.Subjects and methods: This study included 46 patients (46 eyes with primary open-angle glaucoma who had been treated with latanoprost. Dorzolamide (1% was added to latanoprost, and the intraocular pressure (IOP was monitored before and after 3, 6, and 12 months. The mean deviation shown by Humphrey perimetry was compared before and after twelve months of treatment. Adverse reactions were monitored over the 12-month study period.Results: The mean baseline IOP was 17.2 ± 3.0 mmHg while those after 3, 6 and 12 months of treatment were 14.9 ± 3.0 mmHg, 14.5 ± 3.2 mmHg, and 14.6 ± 2.6 mmHg respectively (P < 0.0001, 1-ß(power = 0.9999571. The absolute reduction of IOP and the percent reduction were similar after 3, 6, and 12 months of treatment. The mean deviation on Humphrey perimetry was similar before and after twelve months of treatment. Three patients discontinued dorzolamide therapy due to elevation of IOP and one patient discontinued it because of adverse reactions.Conclusion: Dorzolamide is safe and effective when used for twelve months as add-on therapy to latanoprost for open-angle glaucoma.Keywords: dorzolamide, primary open-angle glaucoma, latanoprost 

  5. Do supervised weekly exercise programs maintain functional exercise capacity and quality of life, twelve months after pulmonary rehabilitation in COPD?

    Directory of Open Access Journals (Sweden)

    Alison Jennifer A

    2007-05-01

    Full Text Available Abstract Background Pulmonary rehabilitation programs have been shown to increase functional exercise capacity and quality of life in COPD patients. However, following the completion of pulmonary rehabilitation the benefits begin to decline unless the program is of longer duration or ongoing maintenance exercise is followed. Therefore, the aim of this study is to determine if supervised, weekly, hospital-based exercise compared to home exercise will maintain the benefits gained from an eight-week pulmonary rehabilitation program in COPD subjects to twelve months. Methods Following completion of an eight-week pulmonary rehabilitation program, COPD subjects will be recruited and randomised (using concealed allocation in numbered envelopes into either the maintenance exercise group (supervised, weekly, hospital-based exercise or the control group (unsupervised home exercise and followed for twelve months. Measurements will be taken at baseline (post an eight-week pulmonary rehabilitation program, three, six and twelve months. The exercise measurements will include two six-minute walk tests, two incremental shuttle walk tests, and two endurance shuttle walk tests. Oxygen saturation, heart rate and dyspnoea will be monitored during all these tests. Quality of life will be measured using the St George's Respiratory Questionnaire and the Hospital Anxiety and Depression Scale. Participants will be excluded if they require supplemental oxygen or have neurological or musculoskeletal co-morbidities that will prevent them from exercising independently. Discussion Pulmonary rehabilitation plays an important part in the management of COPD and the results from this study will help determine if supervised, weekly, hospital-based exercise can successfully maintain functional exercise capacity and quality of life following an eight-week pulmonary rehabilitation program in COPD subjects in Australia.

  6. Chapter Twelve

    African Journals Online (AJOL)

    User

    dissemination in Nigeria· Some local jingles from Radio Nigeria Purity F.M. .... Indigenous Language in Advertisement: Problems and Prospects – Thecla ... the rural newspapers from performing their role of rural development· The ..... Sharma Raman, M· and, S (2004), Technical Communication Principle and Practice· India:.

  7. Deathly silence and apocalyptic noise: Observations on the soundscape of the Book of the Twelve

    Directory of Open Access Journals (Sweden)

    Aaron Schart

    2010-03-01

    Full Text Available This paper proposes a reading of the Book of the Twelve (used interchangeably with �Twelve� and �Book� for convenience that concentrates on the sound that is included in the description of the world of the text. Three onomatopoeic devices are singled out. First, the mourning cry h�y is considered. This interjection is used differently in several of the writings: in Amos (5:18; 6:1 the prophet cries out in compassion with the addressees. By contrast, in Nahum 3:1 and Habakkuk 2:6�19, h�y is uttered in a mood of mockery. In Zechariah 2:10 a third, joyful h�y is used. It appears that the different usages cohere nicely with the overall structure of the Book of the Twelve. Secondly, the interjection has likewise shows different usages. In Amos 6:10 and 8:3, it simulates the last breath of Israelites dying when the land is devastated. By contrast, in Habakkuk 2:20, Zephaniah 1:7 and Zechariah 2:17, the addressees are directed to be silent before YHWH. This command should be perceived as an act of reverence. Again, the sequence of the occurrences coheres with the overall structure of the Book of the Twelve. Of special relevance is that the last three instances build a frame around the Babylonian exile, which lies between Zephaniah and Haggai. The third example is the phrase ham�n�m, ham�n�m in Joel 4:14. The author employs an irregular double plural to construe this place as the loudest spot (�apocalyptic noise� within the Twelve.Setu sa go tiba le modumo wa aphokhaliptiki: Ditemogo ka medumo ya Puku ya ba LesomepediPampiri ye e �i�inya go balwa ga Puku ya ba Lesomepedi (yeo e ka nogo bit�wa �Lesomepedi� goba �Puku� go bebofat�a ditaba ka go gatelela modumo wo o lego ka gare ga tlhaloso ya lefase la go tswala dingwalo t�e. Ditsela t�e tharo t�a onomathopoiki di bewa pepeneng. La mathomo, go �et�wa sello sa mahloko sa h?y. Lelahlelwa le le �omi�wa ka go fapana mo dingwalong t�e mmalwa: go Amosi

  8. Twelve new species and fifty-three new provincial distribution records of Aleocharinae rove beetles of Saskatchewan, Canada (Coleoptera, Staphylinidae).

    Science.gov (United States)

    Klimaszewski, Jan; Larson, David J; Labrecque, Myriam; Bourdon, Caroline

    2016-01-01

    One hundred twenty species of aleocharine beetles (Staphylinidae) are recognized in the province of Saskatchewan. Sixty-five new provincial records, including twelve new species and one new North American record, are presented. Oligota inflata (Mannerheim), a Palearctic species, is newly recorded for North America. The following twelve species are described as new to science: Acrotona pseudopygmaea Klimaszewski & Larson, sp. n., Agaricomorpha pulchra Klimaszewski & Larson, sp. n. (new genus record for Canadian fauna), Aleochara elisabethae Klimaszewski & Larson, sp. n., Atheta (Dimetrota) larsonae Klimaszewski & Larson, sp. n., Atheta (Microdota) pseudopittionii Klimaszewski & Larson, sp. n., Atheta (Microdota) spermathecorum Klimaszewski & Larson, sp. n., Atheta (sensu lato) richardsoni Klimaszewski & Larson, sp. n., Brachyusa saskatchewanae Klimaszewski & Larson, sp. n., Dochmonota langori Klimaszewski & Larson, sp. n., Dochmonota simulans Klimaszewski & Larson, sp. n., Dochmonota websteri Klimaszewski & Larson, sp. n., and Oxypoda domestica Klimaszewski & Larson, sp. n. Colour images of habitus and black and white images of the median lobe of the aedeagus, spermatheca, and tergite and sternite VIII are presented for all new species, Oligota inflata Mannerheim and Dochmonota rudiventris (Eppelsheim). A new synonymy is established: Tetralina filitarsus Casey, syn. n. = Tetralina helenae Casey, now placed in the genus Brachyusa Mulsant & Rey.

  9. A survey of innovation through duplication in the reduced genomes of twelve parasites.

    Directory of Open Access Journals (Sweden)

    Jeremy D DeBarry

    Full Text Available We characterize the prevalence, distribution, divergence, and putative functions of detectable two-copy paralogs and segmental duplications in the Apicomplexa, a phylum of parasitic protists. Apicomplexans are mostly obligate intracellular parasites responsible for human and animal diseases (e.g. malaria and toxoplasmosis. Gene loss is a major force in the phylum. Genomes are small and protein-encoding gene repertoires are reduced. Despite this genomic streamlining, duplications and gene family amplifications are present. The potential for innovation introduced by duplications is of particular interest. We compared genomes of twelve apicomplexans across four lineages and used orthology and genome cartography to map distributions of duplications against genome architectures. Segmental duplications appear limited to five species. Where present, they correspond to regions enriched for multi-copy and species-specific genes, pointing toward roles in adaptation and innovation. We found a phylum-wide association of duplications with dynamic chromosome regions and syntenic breakpoints. Trends in the distribution of duplicated genes indicate that recent, species-specific duplicates are often tandem while most others have been dispersed by genome rearrangements. These trends show a relationship between genome architecture and gene duplication. Functional analysis reveals: proteases, which are vital to a parasitic lifecycle, to be prominent in putative recent duplications; a pair of paralogous genes in Toxoplasma gondii previously shown to produce the rate-limiting step in dopamine synthesis in mammalian cells, a possible link to the modification of host behavior; and phylum-wide differences in expression and subcellular localization, indicative of modes of divergence. We have uncovered trends in multiple modes of duplicate divergence including sequence, intron content, expression, subcellular localization, and functions of putative recent duplicates that

  10. Isolation and characterization of twelve microsatellite loci for the Japanese Devilray (Mobula japanica)

    NARCIS (Netherlands)

    Poortvliet, Marloes; Galvan-Magana, Felipe; Bernardi, Giacomo; Croll, Donald A.; Olsen, Jeanine L.

    2011-01-01

    Twelve polymorphic microsatellites loci were characterized for Mobula japanica (Japanese Devilray) using an enrichment protocol. All but two loci were in Hardy-Weinberg equilibrium with no evidence of linkage disequilibrium or null-alleles for a sample of 40 individuals from two populations. The num

  11. 17 CFR 210.3-06 - Financial statements covering a period of nine to twelve months.

    Science.gov (United States)

    2010-04-01

    ... ACT OF 1933, SECURITIES EXCHANGE ACT OF 1934, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935, INVESTMENT COMPANY ACT OF 1940, INVESTMENT ADVISERS ACT OF 1940, AND ENERGY POLICY AND CONSERVATION ACT OF 1975... to twelve months. Except with respect to registered investment companies, the filing of...

  12. Portrayal of Life Form in Selected Biographies for Children Eight to Twelve Years of Age.

    Science.gov (United States)

    Koch, Shirley Lois

    This study describes and analyzes, in a critical literary manner, selected biographies for children eight to twelve years of age. Biographies of Jane Addams, Cesar Chavez, Mohandas Gandhi, Toyohiko Kagawa, Martin Luther King, Jr., and Albert Schweitzer are viewed from the perspective of a literary criterion based on the principles of design to…

  13. Premarital sex in the last twelve months and its predictors among ...

    African Journals Online (AJOL)

    Premarital sex in the last twelve months and its predictors among students of ... Statistical significance was determined through a 95% confidence level. ... having comprehensive knowledge of HIV [AOR(95% CI)=1.5(1.01-2.10)], alcohol use ...

  14. Portrayal of Life Form in Selected Biographies for Children Eight to Twelve Years of Age.

    Science.gov (United States)

    Koch, Shirley Lois

    This study describes and analyzes, in a critical literary manner, selected biographies for children eight to twelve years of age. Biographies of Jane Addams, Cesar Chavez, Mohandas Gandhi, Toyohiko Kagawa, Martin Luther King, Jr., and Albert Schweitzer are viewed from the perspective of a literary criterion based on the principles of design to…

  15. A novel double quad-inverter configuration for multilevel twelve-phase open-winding converter

    DEFF Research Database (Denmark)

    Padmanaban, Sanjeevi Kumar; Blaabjerg, Frede; Wheeler, Patrick William

    2016-01-01

    This paper describes a novel proposal of double quad-inverter configuration for multilevel twelve-phase open-winding ac converter. Modular power units are developed from reconfigured eight classical three-phase voltage source inverters (VSIs). Each VSI has one additional bi-directional switching ...

  16. Nutrient Contents per Serving of Twelve Varieties of Cooked Rice Marketed in Jordan

    Directory of Open Access Journals (Sweden)

    Jafar M. El-Qudah

    2008-01-01

    Full Text Available Jordan imports rice from different countries without any quality preferences. Twelve varieties of cooked rice marketed in Jordan were analyzed. The content per serving of these varieties were computed for energy, protein, carbohydrates, fat, calcium, sodium, potassium, magnesium, manganese, copper, iron and phosphorous. The protein content per serving found to range from 0.49 g for La Cigala rice to 6.2 g for Harvest rice. The fat content for all rice brands was less than 0.37 g per serving. The energy content ranged from 172.12 g/serving for Basmati rice to 212.25 g/serving for Sun White rice. Generally, all rice varieties contain significant amounts of minerals per serving. Ruzzana found to contain the highest level of calcium (38.2 mg/serving and Amber the lowest calcium content (6.7 mg/serving. Magnesium content found to range from 5.7 mg/serving for Royal Umberella rice to 16.3 mg/serving for Ruzzana rice. Consumption of one serving of Harvest cooked rice will cover 13.5% of the daily requirement of protein for females and 11.1% for males. Manganese content of one serving of Harvest, Sun White, Abu bent and La Cigala will cover 22.2% of the daily requirements for females and 14.7% for males, while consumption of one of Basmati, Sos rice or Amber will cover only 11.1% and 8.75 of requirement for females and males respectively. Planning a healthful diet is not a simple task. Dietary Reference Intake planning and assessing the diets of individuals or groups of healthy individuals according to their stage of life and sex. Food choice is a function of many factors, including personal preferences, habits, ethnic heritage and tradition. Dietary guidelines for Americans, consider whole grain products like rice are among the food groups that form the basis of a healthy diet. Including rice as part of a healthy, balanced diet can be linked to overall healthier eating patterns. Rice eaters are more likely to eat a diet consistent with the 2005 Dietary

  17. Experiencing a constructivist museum exhibit: A case study of twelve children and their families

    Science.gov (United States)

    Hill, Martha Anne Leech

    2002-04-01

    The American Association for the Advancement of Science and the National Research Council have called for the creation of a scientifically literate populace and introduced science standards and guidelines to direct this process. Science education in traditional school settings plays a key role in reaching this goal, but individuals over their lifetimes will have more exposure to science ideas through informal science experiences such as visits to museums and through diverse media sources. The purpose of this study was to explore the role museums play in this journey to science literacy. This qualitative collective case study examined the experience of 12 children and their families in a children's museum as they interacted with an exhibit designed along the tenets of constructivist theory to introduce children to ideas of science. Twelve children and their families were videotaped interacting with a model of a watershed that included the stream, surrounding land, gravel, and dam building and erosion abatement manipulatives. Children were interviewed to ascertain their stream-related ideas and conceptual understanding prior to and after using the exhibit. Parents completed demographic and post-exhibit experience questionnaires. Two museum staff members who played key roles in the development of the exhibit and surrounding gallery were also interviewed. Individual and cross-case analyses were done to describe the experience of each child and family, and to elucidate the commonalities of these experiences to describe the phenomenon of using a constructivist-based science exhibit. Results of the study indicate (1) the type of experience children and families had at the exhibit depended on child and parent interactions and roles each assumed, and (2) experience with the exhibit encouraged children to think more deeply about water topics, past experiences, and ideas they had previously constructed. Implications of this research include (1) parents should engage children

  18. Anatomical studies on twelve clones of Camellia species with reference to their taxonomic significance

    Directory of Open Access Journals (Sweden)

    Rajanna L

    2010-10-01

    Full Text Available Anatomical studies of leaf and stem of twelve clones of Camellia were investigated. Cross sections of the stem of all the clones exhibited a typical pattern of arrangement of tissues characteristics of woody plants. Two types of idioblastic sclereids were found in the medullary parenchyma of the taxa studied. While astrosclereids werepresent in 10 of the twelve clones, the vesciculose sclereids were found only in the four clones belonging to C. sinensis. Leaves of the clones show variations in the number of palisade layers. Astro sclereids, brachy sclereids, and dendritic forms were observed in the leaves, their distribution varying in the different clones. A few other micromorphological features are also recorded. Our study forms a basis for answering uncertainties in taxonomic revision in the genus Camellia.

  19. Risk factors for chronic noncontiguous diseases: Twelve-week prospective study

    Directory of Open Access Journals (Sweden)

    Lapčević Mirjana

    2004-01-01

    Full Text Available Risk factors (RF of chronic noncontiguous diseases (CND are mutual and cannot be observed individually since there is an inter-reaction (interaction of RF in various combinations, what makes so-called personality risk profile for development of particular disease. Almost all CND belong to the group of preventable diseases, because their course may be influenced and changed through RF modification and reduction. Bad habits also contribute to CND incidence. CND prevention is the first priority of primary health care physicians. The main objective of our study was to detect RF in patients during everyday activities of general practitioner, to estimate the risk of CND within the existing RF combination, to show the results of 12-week active monitoring of population with RF of CND, and with already present CND; while the secondary goal was to assess how much population is interested in active collaboration as well as to evaluate the qualification of general medicine teams for work based on defined methodology. The study was multicentric, prospective and interventional. The study included 2086 subjects, aged from 25-64 years, and it was carried out in 17 health centers throughout Serbia in the period January-April 2002. The subjects were selected by method of open clinical experiment. Thereafter, 12-week medical intervention was initiated involving non-pharmacological and pharmacological treatment. The first control was scheduled after 8, and the second after 12 months of intervention. Congruence χ2 test, ANOVA for repeated measurements and Logistic regression were used for statistical data processing. Out of a total of 2086 subjects, the following proportion of them reported specific diagnosis in their medical histories: 77% of them reported arterial hypertension (HTA, 68% - increased body mass (BMI>27Kg/m2, 66% - hyperlipoproteinemia (HLP, 34% - diabetes mellitus (DM, 56% - inadequate physical activity (PA, and 23% - cigarette smoking (CS. On the

  20. [Risk factors for chronic noncontiguous diseases: twelve-week prospective study].

    Science.gov (United States)

    Lapcević, Mirjana; Vuković, Mira

    2004-01-01

    Risk factors (RF) of chronic noncontiguous diseases (CND) are mutual and cannot be observed individually since there is an inter-reaction (interaction of RF in various combinations), what makes so-called personality risk profile for development of particular disease. Almost all CND belong to the group of preventable diseases, because their course may be influenced and changed through RF modification and reduction. Bad habits also contribute to CND incidence. CND prevention is the first priority of primary health care physicians. The main objective of our study was to detect RF in patients during everyday activities of general practitioner, to estimate the risk of CND within the existing RF combination, to show the results of 12-week active monitoring of population with RF of CND, and with already present CND; while the secondary goal was to assess how much population is interested in active collaboration as well as to evaluate the qualification of general medicine teams for work based on defined methodology. The study was multicentric, prospective and interventional. The study included 2086 subjects, aged from 25-64 years, and it was carried out in 17 health centers throughout Serbia in the period January-April 2002. The subjects were selected by method of open clinical experiment. Thereafter, 12-week medical intervention was initiated involving non-pharmacological and pharmacological treatment. The first control was scheduled after 8, and the second after 12 months of intervention. Congruence chi2 test, ANOVA for repeated measurements and Logistic regression were used for statistical data processing. Out of a total of 2086 subjects, the following proportion of them reported specific diagnosis in their medical histories: 77% of them reported arterial hypertension (HTA), 68%--increased body mass (BMI > or = 27Kg/m2), 66%--hyperlipoproteinemia (HLP), 34%--diabetes mellitus (DM), 56%--inadequate physical activity (PA), and 23%--cigarette smoking (CS). On the basis of

  1. Descriptions of twelve new species of ochyroceratids (Araneae, Ochyroceratidae) from mainland Ecuador.

    Science.gov (United States)

    Dupérré, Nadine

    2015-05-12

    Twelve new species in three different genera from the spider family Ochyroceratidae are described from mainland Ecuador: Speocera bioforestae sp. n., Speocera violacea sp. n., Speocera musgo sp. n., Ochyrocera rinocerotos sp. n., Ochyrocera callaina sp. n., Ochyrocera italoi sp. n., Ochyrocera minotaure sp. n., Ochyrocera losrios sp. n., Ochyrocera zabaleta sp. n., Ochyrocera otonga sp. n., Ochyrocera cashcatotoras sp. n. and Psiloochyrocera tortilis sp. n. Speocera machadoi Gertsch 1977 is transferred to Ochyrocera.

  2. A Hidden Twelve-Dimensional SuperPoincare Symmetry In Eleven Dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Bars, Itzhak; Deliduman, Cemsinan; Pasqua, Andrea; Zumino, Bruno

    2003-12-13

    First, we review a result in our previous paper, of how a ten-dimensional superparticle, taken off-shell, has a hidden eleven-dimensional superPoincare symmetry. Then, we show that the physical sector is defined by three first-class constraints which preserve the full eleven-dimensional symmetry. Applying the same concepts to the eleven dimensional superparticle, taken off-shell, we discover a hidden twelve dimensional superPoincare symmetry that governs the theory.

  3. Hidden twelve-dimensional super Poincaré symmetry in eleven dimensions

    CERN Document Server

    Bars, Itzhak; Pasqua, A; Zumino, B; Bars, Itzhak; Deliduman, Cemsinan; Pasqua, Andrea; Zumino, Bruno

    2004-01-01

    First, we review a result in our previous paper, of how a ten-dimensional superparticle, taken off-shell, has a hidden eleven-dimensional superPoincare symmetry. Then, we show that the physical sector is defined by three first-class constraints which preserve the full eleven-dimensional symmetry. Applying the same concepts to the eleven dimensional superparticle, taken off-shell, we discover a hidden twelve dimensional superPoincare symmetry that governs the theory.

  4. Optical modulator including grapene

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Ming; Yin, Xiaobo; Zhang, Xiang

    2016-06-07

    The present invention provides for a one or more layer graphene optical modulator. In a first exemplary embodiment the optical modulator includes an optical waveguide, a nanoscale oxide spacer adjacent to a working region of the waveguide, and a monolayer graphene sheet adjacent to the spacer. In a second exemplary embodiment, the optical modulator includes at least one pair of active media, where the pair includes an oxide spacer, a first monolayer graphene sheet adjacent to a first side of the spacer, and a second monolayer graphene sheet adjacent to a second side of the spacer, and at least one optical waveguide adjacent to the pair.

  5. Visual Impairment, Including Blindness

    Science.gov (United States)

    ... Who Knows What? Survey Item Bank Search for: Visual Impairment, Including Blindness Links updated, April 2017 En ... doesn’t wear his glasses. Back to top Visual Impairments in Children Vision is one of our ...

  6. Ultra pressure liquid chromatography-negative electrospray ionization mass spectrometry determination of twelve halobenzoquinones at ng/L levels in drinking water.

    Science.gov (United States)

    Huang, Rongfu; Wang, Wei; Qian, Yichao; Boyd, Jessica M; Zhao, Yuli; Li, Xing-Fang

    2013-05-01

    We report here the characterization of twelve halobenzoquinones (HBQs) using electrospray ionization (ESI) high resolution quadrupole time-of-flight mass spectrometry. The high resolution negative ESI spectra of the twelve HBQs formed two parent ions, [M + H(+) + 2e(-)], and the radical M(-•). The intensities of these two parent ions are dependent on their chemical structures and on instrumental parameters such as the source temperature and flow rate. The characteristic ions of the HBQs were used to develop an ultra pressure liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method. At the UPLC flow rate (400 μL/min) and under the optimized ESI conditions, eleven HBQs showed the stable and abundant transitions [M + H(+) + 2e(-)] → X(-) (X(-) representing Cl(-), Br(-), or I(-)), while dibromo-dimethyl-benzoquinone (DBDMBQ) showed only the transition of M(-•) → Br(-). The UPLC efficiently separates all HBQs including some HBQ isomers, while the MS/MS offers exquisite limits of detection (LODs) at subng/mL levels for all HBQs except DBDMBQ. Combined with solid phase extraction (SPE), the method LOD is down to ng/L. The results from analysis of authentic samples demonstrated that the SPE-UPLC-MS/MS method is reliable, fast, and sensitive for the identification and quantification of the twelve HBQs in drinking water.

  7. The Twelve Promises of Alcoholics Anonymous: psychometric measure validation and mediational testing as a 12-step specific mechanism of behavior change.

    Science.gov (United States)

    Kelly, John F; Greene, M Claire

    2013-12-01

    Empirical support for the recovery utility of 12-step mutual-help organizations (MHOs) has led to increased investigation of how such organizations confer benefit. The Twelve Promises of Alcoholics Anonymous (AA) feature prominently in 12-step philosophy and culture and are one of the few documented explications of the cognitive, affective, and behavioral benefits that members might accrue. This study investigated the psychometric properties of a measure of AA's Twelve Promises and examined whether it mediated the effect of 12-step participation on abstinence. Young adults (N=302, M age 20.4 [1.6], range 18-25; 27% female; 95% White) enrolled in an addiction treatment effectiveness study completed assessments at intake and 3-, 6-, and 12-months post treatment including a 26-item, Twelve Promises Scale (TPS). Factor analyses examined the TPS' psychometrics and lagged mediational analyses tested the TPS as a mechanism of behavior change. Robust principal axis factoring extraction with Varimax rotation revealed a 2-factor solution explaining 45-58% of the variance across three administrations ("Psychological Wellbeing"=26-39%; "Freedom from Craving=17-21%); internal consistency was high (alpha=.83-.93). Both factors were found to increase in relation to greater 12-step participation, but significant mediation was found only for the Freedom from Craving factor explaining 21-34% of the effect of 12-step participation in increasing abstinence. The TPS shows potential as a conceptually relevant, and psychometrically sound measure and may be useful in helping elucidate the extent to which the Twelve Promises emerge as an independent benefit of 12-step participation and/or explain SUD remission and recovery. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  8. Analytic device including nanostructures

    KAUST Repository

    Di Fabrizio, Enzo M.

    2015-07-02

    A device for detecting an analyte in a sample comprising: an array including a plurality of pixels, each pixel including a nanochain comprising: a first nanostructure, a second nanostructure, and a third nanostructure, wherein size of the first nanostructure is larger than that of the second nanostructure, and size of the second nanostructure is larger than that of the third nanostructure, and wherein the first nanostructure, the second nanostructure, and the third nanostructure are positioned on a substrate such that when the nanochain is excited by an energy, an optical field between the second nanostructure and the third nanostructure is stronger than an optical field between the first nanostructure and the second nanostructure, wherein the array is configured to receive a sample; and a detector arranged to collect spectral data from a plurality of pixels of the array.

  9. Investigations of body scales in twelve Heterocapsa species (Peridiniales, Dinophyceae), including a new species H. pseudotriquetra sp. nov

    DEFF Research Database (Denmark)

    Iwataki, M.; Hansen, Gert; Sawaguchi, T.;

    2004-01-01

    basal plate and a three-dimensional construction composed of vertically standing uprights or spines and horizontal bars. This basic scale structure is considered to be a generic characteristic. Finer scale details such as the shape and presence of a central hole in the basal plate, the numbers...... of uprights, bars and spines are considered to be species-specific. Two types of scales were found within clonal cultures of H. arctica and H. circularisquama and it is suggested that these represent ‘mature' and ‘immature' body scales. Intraspecific variation of the basal plate ‘reticulation' was also...... observed. This variation was particularly evident in prolonged cultures of H. horiguchii and H. rotundata. The body-scale structure of 11 described species can be distinguished. However, two species, namely H. triquetra and H. pseudotriquetra, have the same scale morphology and are distinguished...

  10. Definition of a Twelve-Point Polygonal SAA Boundaryfor the GLAST Mission

    Energy Technology Data Exchange (ETDEWEB)

    Djomehri, Sabra I.; /UC, Santa Cruz /SLAC

    2007-08-29

    The Gamma-Ray Large Area Space Telescope (GLAST), set to launch in early 2008, detects gamma rays within a huge energy range of 100 MeV - 300 GeV. Background cosmic radiation interferes with such detection resulting in confusion over distinguishing cosmic from gamma rays encountered. This quandary is resolved by encasing GLAST's Large Area Telescope (LAT) with an Anti-Coincidence Detector (ACD), a device which identifies and vetoes charged particles. The ACD accomplishes this through plastic scintillator tiles; when cosmic rays strike, photons produced induce currents in Photomultiplier Tubes (PMTs) attached to these tiles. However, as GLAST orbits Earth at altitudes {approx}550km and latitudes between -26 degree and 26 degree, it will confront the South Atlantic Anomaly (SAA), a region of high particle flux caused by trapped radiation in the geomagnetic field. Since the SAA flux would degrade the sensitivity of the ACD's PMTs over time, a determined boundary enclosing this region need be attained, signaling when to lower the voltage on the PMTs as a protective measure. The operational constraints on such a boundary require a convex SAA polygon with twelve edges, whose area is minimal ensuring GLAST has maximum observation time. The AP8 and PSB97 models describing the behavior of trapped radiation were used in analyzing the SAA and defining a convex SAA boundary of twelve sides. The smallest possible boundary was found to cover 14.58% of GLAST's observation time. Further analysis of defining a boundary safety margin to account for inaccuracies in the models reveals if the total SAA hull area is increased by {approx}20%, the loss of total observational area is < 5%. These twelve coordinates defining the SAA flux region are ready for implementation by the GLAST satellite.

  11. The correlation between reading and mathematics ability at age twelve has a substantial genetic component.

    Science.gov (United States)

    Davis, Oliver S P; Band, Gavin; Pirinen, Matti; Haworth, Claire M A; Meaburn, Emma L; Kovas, Yulia; Harlaar, Nicole; Docherty, Sophia J; Hanscombe, Ken B; Trzaskowski, Maciej; Curtis, Charles J C; Strange, Amy; Freeman, Colin; Bellenguez, Céline; Su, Zhan; Pearson, Richard; Vukcevic, Damjan; Langford, Cordelia; Deloukas, Panos; Hunt, Sarah; Gray, Emma; Dronov, Serge; Potter, Simon C; Tashakkori-Ghanbaria, Avazeh; Edkins, Sarah; Bumpstead, Suzannah J; Blackwell, Jenefer M; Bramon, Elvira; Brown, Matthew A; Casas, Juan P; Corvin, Aiden; Duncanson, Audrey; Jankowski, Janusz A Z; Markus, Hugh S; Mathew, Christopher G; Palmer, Colin N A; Rautanen, Anna; Sawcer, Stephen J; Trembath, Richard C; Viswanathan, Ananth C; Wood, Nicholas W; Barroso, Ines; Peltonen, Leena; Dale, Philip S; Petrill, Stephen A; Schalkwyk, Leonard S; Craig, Ian W; Lewis, Cathryn M; Price, Thomas S; Donnelly, Peter; Plomin, Robert; Spencer, Chris C A

    2014-07-08

    Dissecting how genetic and environmental influences impact on learning is helpful for maximizing numeracy and literacy. Here we show, using twin and genome-wide analysis, that there is a substantial genetic component to children's ability in reading and mathematics, and estimate that around one half of the observed correlation in these traits is due to shared genetic effects (so-called Generalist Genes). Thus, our results highlight the potential role of the learning environment in contributing to differences in a child's cognitive abilities at age twelve.

  12. Developing a learning culture: twelve tips for individuals, teams and organizations.

    Science.gov (United States)

    Stinson, Lynn; Pearson, David; Lucas, Beverley

    2006-06-01

    A culture of learning in providing health services and education for health professionals is a constant challenge for individuals, team and organizations. The importance of such a culture was highlighted by the findings of the Bristol Royal Infirmary Inquiry (2001). This was discussed in the context of the literature on the Learning Organization (Senge, 1990) at the 2004 Association of Medical Education in Europe (AMEE) conference, and reviewed a year later at the 2005 AMEE conference. This paper outlines twelve tips for educational and health service organizations in facilitating a culture of learning for their members and also offers specific advice to individual students and professionals.

  13. Work environment perceptions following relocation to open-plan offices: A twelve-month longitudinal study.

    Science.gov (United States)

    Bergström, Jessica; Miller, Michael; Horneij, Eva

    2015-01-01

    A workplace's design can have various positive or negative effects on the employees and since the 1970s the advantages and disadvantages of open-plan offices have been discussed. The aim of this study was to investigate perceived health, work environment and self-estimated productivity one month before and at three, six and twelve months after relocation from individual offices to an open-plan office environment. Employees from three departments within the same company group and who worked with relatively similar tasks and who were planned to be relocated from private offices to open-plan offices were invited to participate. Questionnaires comprising items from The Salutogenic Health Indicator Scale, The Work Experience Measurement Scale, the questionnaire by Brennan et al. about perceived performance and one question from the Work Ability Index were sent to participants one month before relocation (baseline) to open-plan offices and then at three, six and twelve months after relocation. At baseline, 82 questionnaires were sent out. The response rate was 85%. At the follow-ups 77-79 questionnaires were sent out and the response-rate was 70%-81%. At follow-ups, perceived health, job satisfaction and performance had generally deteriorated. The results of the study indicate that employees' perception of health, work environment and performance decreased during a 12 month period following relocation from individual offices to open-plan offices.

  14. Approximate analytic method for high-apogee twelve-hour orbits of artificial Earth's satellites

    Science.gov (United States)

    Vashkovyaka, M. A.; Zaslavskii, G. S.

    2016-09-01

    We propose an approach to the study of the evolution of high-apogee twelve-hour orbits of artificial Earth's satellites. We describe parameters of the motion model used for the artificial Earth's satellite such that the principal gravitational perturbations of the Moon and Sun, nonsphericity of the Earth, and perturbations from the light pressure force are approximately taken into account. To solve the system of averaged equations describing the evolution of the orbit parameters of an artificial satellite, we use both numeric and analytic methods. To select initial parameters of the twelve-hour orbit, we assume that the path of the satellite along the surface of the Earth is stable. Results obtained by the analytic method and by the numerical integration of the evolving system are compared. For intervals of several years, we obtain estimates of oscillation periods and amplitudes for orbital elements. To verify the results and estimate the precision of the method, we use the numerical integration of rigorous (not averaged) equations of motion of the artificial satellite: they take into account forces acting on the satellite substantially more completely and precisely. The described method can be applied not only to the investigation of orbit evolutions of artificial satellites of the Earth; it can be applied to the investigation of the orbit evolution for other planets of the Solar system provided that the corresponding research problem will arise in the future and the considered special class of resonance orbits of satellites will be used for that purpose.

  15. Global surface temperature change analysis based on MODIS data in recent twelve years

    Science.gov (United States)

    Mao, K. B.; Ma, Y.; Tan, X. L.; Shen, X. Y.; Liu, G.; Li, Z. L.; Chen, J. M.; Xia, L.

    2017-01-01

    Global surface temperature change is one of the most important aspects in global climate change research. In this study, in order to overcome shortcomings of traditional observation methods in meteorology, a new method is proposed to calculate global mean surface temperature based on remote sensing data. We found that (1) the global mean surface temperature was close to 14.35 °C from 2001 to 2012, and the warmest and coldest surface temperatures of the global in the recent twelve years occurred in 2005 and 2008, respectively; (2) the warmest and coldest surface temperatures on the global land surface occurred in 2005 and 2001, respectively, and on the global ocean surface in 2010 and 2008, respectively; and (3) in recent twelve years, although most regions (especially the Southern Hemisphere) are warming, global warming is yet controversial because it is cooling in the central and eastern regions of Pacific Ocean, northern regions of the Atlantic Ocean, northern regions of China, Mongolia, southern regions of Russia, western regions of Canada and America, the eastern and northern regions of Australia, and the southern tip of Africa. The analysis of daily and seasonal temperature change indicates that the temperature change is mainly caused by the variation of orbit of celestial body. A big data model based on orbit position and gravitational-magmatic change of celestial body with the solar or the galactic system should be built and taken into account for climate and ecosystems change at a large spatial-temporal scale.

  16. Comparative assay of fluorescent antibody test results among twelve European National Reference Laboratories using various anti-rabies conjugates

    DEFF Research Database (Denmark)

    Robardet, E.; Andrieu, S.; Rasmussen, Thomas Bruun

    2013-01-01

    Twelve National Reference Laboratories (NRLs) for rabies have undertaken a comparative assay to assess the comparison of fluorescent antibody test (FAT) results using five coded commercial anti-rabies conjugates (Biorad, Bioveta, Fujirebio, Millipore, and SIFIN conjugates). Homogenized positive...

  17. Changes in lipids over twelve months after initiating protease inhibitor therapy among persons treated for HIV/AIDS

    Directory of Open Access Journals (Sweden)

    Hogg Robert S

    2005-02-01

    Full Text Available Abstract Background Protease inhibitors are known to alter the lipid profiles in subjects treated for HIV/AIDS. However, the magnitude of this effect on plasma lipoproteins and lipids has not been adequately quantified. Objective To estimate the changes in plasma lipoproteins and triglycerides occurring within 12 months of initiating PI-based antiretroviral therapy among HIV/AIDS afflicted subjects. Methods We included all antiretroviral naïve HIV-infected persons treated at St-Paul's Hospital, British Columbia, Canada, who initiated therapy with protease inhibitor antiretroviral (ARV drugs between August 1996 and January 2002 and who had at least one plasma lipid measurement. Longitudinal associations between medication use and plasma lipids were estimated using mixed effects models that accounted for repeated measures on the same subjects and were adjusted for age, sex, time dependent CD4+ T-cell count, and time dependent cumulative use of non-nucleoside reverse transcriptase inhibitors and adherence. The cumulative number of prescriptions filled for PIs was considered time dependent. We estimated the changes in the 12 months following any initiation of a PI based regimen. Results A total of 679 eligible subjects were dispensed nucleoside analogues and PI at the initiation of therapy. Over a median 47 months of follow-up (interquartile range (IQR: 29–62, subjects had a median of 3 (IQR: 1–6 blood lipid measurements. Twelve months after treatment initiation of PI use, there was an estimated 20% (95% confidence interval: 17% – 24% increase in total cholesterol and 22% (12% – 33% increase in triglycerides. Conclusions Twelve months after treatment initiation with PIs, statistically significant increases in total cholesterol and triglycerides levels were observed in HIV-infected patients under conditions of standard treatment. Our results contribute to the growing body of evidence implicating PIs in the development of blood lipid

  18. Measuring performance in off-patent drug markets: a methodological framework and empirical evidence from twelve EU Member States.

    Science.gov (United States)

    Kanavos, Panos

    2014-11-01

    This paper develops a methodological framework to help evaluate the performance of generic pharmaceutical policies post-patent expiry or after loss of exclusivity in non-tendering settings, comprising five indicators (generic availability, time delay to and speed of generic entry, number of generic competitors, price developments, and generic volume share evolution) and proposes a series of metrics to evaluate performance. The paper subsequently tests this framework across twelve EU Member States (MS) by using IMS data on 101 patent expired molecules over the 1998-2010 period. Results indicate that significant variation exists in generic market entry, price competition and generic penetration across the study countries. Size of a geographical market is not a predictor of generic market entry intensity or price decline. Regardless of geographic or product market size, many off patent molecules lack generic competitors two years after loss of exclusivity. The ranges in each of the five proposed indicators suggest, first, that there are numerous factors--including institutional ones--contributing to the success of generic entry, price decline and market penetration and, second, MS should seek a combination of supply and demand-side policies in order to maximise cost-savings from generics. Overall, there seems to be considerable potential for faster generic entry, uptake and greater generic competition, particularly for molecules at the lower end of the market.

  19. Exploring Content Schemata Influence on L2 Reading: The Hunted Fox and Twelve and Not Stupid

    Directory of Open Access Journals (Sweden)

    Amizura Hanadi Mohd Radzi

    2014-10-01

    Full Text Available This paper will discuss the aspects of content schemata in second language reading among diploma level students who were taking a reading course in Universiti Teknologi MARA Perlis. In this qualitative case study, the researcher had selected two short stories that are categorized as content-familiar texts, i.e. The Hunted Fox and Twelve and Not Stupid. Six participants were asked to write a 150-word entry response on the short story and a grading criteria was used to assess the participants’ level of comprehension. An in-depth interview was also conducted on each participant. The entry responses and the interview patterns were analyzed to determine whether content schemata had contributed to the learners’ understanding of the text. This study discovered that content schemata had contributed to the learners’ understanding of the text because the learners’ comprehension was facilitated by their background knowledge on the content-familiar texts.

  20. Proteomic characterization of human milk whey proteins during a twelve-month lactation period.

    Science.gov (United States)

    Liao, Yalin; Alvarado, Rudy; Phinney, Brett; Lönnerdal, Bo

    2011-04-01

    Human milk is a rich source of bioactive proteins that support the early growth and development of the newborn. Although the major components of the protein fraction in human milk have been studied, the expression and relative abundance of minor components have received limited attention. We examined the expression of low-abundance proteins in the whey fraction of human milk and their dynamic changes over a twelve-month lactation period. The low-abundance proteins were enriched by ProteoMiner beads, and protein identification was performed by liquid chromatography tandem mass spectrometry. One hundred and fifteen proteins were identified, thirty-eight of which have not been previously reported in human colostrum or milk. We also for the first time described differences in protein patterns among the low-abundance proteins during lactation. These results enhance our knowledge about the complexity of the human milk proteome, which constitutes part of the advantages to the breast-fed infant.

  1. Fate of the conformal fixed point with twelve massless fermions and SU(3) gauge group

    CERN Document Server

    Fodor, Zoltan; Kuti, Julius; Mondal, Santanu; Nogradi, Daniel; Wong, Chik Him

    2016-01-01

    We report new results on the conformal properties of an important strongly coupled gauge theory, a building block of composite Higgs models beyond the Standard Model. With twelve massless fermions in the fundamental representation of the SU(3) color gauge group, an infrared fixed point of the $\\beta$-function was recently reported in the theory (Cheng:2014jba) with uncertainty in the location of the critical gauge coupling inside the narrow $[ 6.0

  2. Twelve Tips for teaching medical professionalism at all levels of medical education.

    Science.gov (United States)

    Al-Eraky, Mohamed Mostafa

    2015-01-01

    Review of studies published in medical education journals over the last decade reveals that teaching medical professionalism is essential, yet challenging. According to a recent Best Evidence in Medical Education (BEME) guide, there is no consensus on a theoretical or practical model to integrate the teaching of professionalism into medical education. The aim of this article is to outline a practical manual for teaching professionalism at all levels of medical education. Drawing from research literature and author's experience, Twelve Tips are listed and organised in four clusters with relevance to (1) the context, (2) the teachers, (3) the curriculum, and (4) the networking. With a better understanding of the guiding educational principles for teaching medical professionalism, medical educators will be able to teach one of the most challenging constructs in medical education.

  3. Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolates

    Directory of Open Access Journals (Sweden)

    Hermans Peter WM

    2011-01-01

    Full Text Available Abstract Background M. catarrhalis is a gram-negative, gamma-proteobacterium and an opportunistic human pathogen associated with otitis media (OM and exacerbations of chronic obstructive pulmonary disease (COPD. With direct and indirect costs for treating these conditions annually exceeding $33 billion in the United States alone, and nearly ubiquitous resistance to beta-lactam antibiotics among M. catarrhalis clinical isolates, a greater understanding of this pathogen's genome and its variability among isolates is needed. Results The genomic sequences of ten geographically and phenotypically diverse clinical isolates of M. catarrhalis were determined and analyzed together with two publicly available genomes. These twelve genomes were subjected to detailed comparative and predictive analyses aimed at characterizing the supragenome and understanding the metabolic and pathogenic potential of this species. A total of 2383 gene clusters were identified, of which 1755 are core with the remaining 628 clusters unevenly distributed among the twelve isolates. These findings are consistent with the distributed genome hypothesis (DGH, which posits that the species genome possesses a far greater number of genes than any single isolate. Multiple and pair-wise whole genome alignments highlight limited chromosomal re-arrangement. Conclusions M. catarrhalis gene content and chromosomal organization data, although supportive of the DGH, show modest overall genic diversity. These findings are in stark contrast with the reported heterogeneity of the species as a whole, as wells as to other bacterial pathogens mediating OM and COPD, providing important insight into M. catarrhalis pathogenesis that will aid in the development of novel therapeutic regimens.

  4. Twelve-year cyclic surging episode at Donjek Glacier in Yukon, Canada

    Science.gov (United States)

    Furuya, M.; Abe, T.; Sakakibara, D.

    2015-12-01

    Surge-type glaciers exhibit several-fold to orders-of-magnitude speed-up during the short active phase, resulting in km-scale terminus advance. Although there are many surge-type glaciers near the border of Alaska and the Yukon, the generation mechanisms remain uncertain because of limited and few continuous observations. To better understand the surge dynamics and predict the next event, it is essential to examine the entire surge cycles. Here we use Landsat optical imageries to reveal the long-term evolutions, and report three surging episodes at Donjek Glacier in Yukon, Canada. Using the Landsat images, we found three surging events in 1989, 2001, and 2013. In the 2001 event, the surface speed significantly increased by up to 4.5 m/d; during the quiescent phases it was ~0.5 m/d at the terminus. While the duration of active phase is about 4~5 and 2~3 year in the 2001 and 2013 events, the period in the 1989 event is unclear because of the lack of high temporal resolution data. Remarkably, the surging area is limited to the ~20-km section from the terminus instead of the entire glacier. Moreover, we examined the terminus area changes from 1975 to 2014. Although the area has been secularly decreasing probably due to the tread of global warming, it has also revealed four significant fluctuations during the nearly forty years. Comparing the speed and the area changes, the three speed-up events correspond to the terminus area fluctuations with a few time lags. It turns out that the surge event has been quite regularly repeating every twelve years. Although the behavior is rather similar to that in Svalbard glaciers in terms of maximum speed and unclear initiation season, the recurrence interval is much shorter than other nearby surges. Considering that the surge events seem to have initiated around significantly narrower area than upstream, the strong valley constriction may control the regularity as well as the twelve-year recurrence time.

  5. Evolution and potential function of fibrinogen-like domains across twelve Drosophila species

    Directory of Open Access Journals (Sweden)

    Middha Sumit

    2008-05-01

    Full Text Available Abstract Background The fibrinogen-like (FBG domain consists of approximately 200 amino acid residues, which has high sequence similarity to the C-terminal halves of fibrinogen β and γ chains. Fibrinogen-related proteins (FREPs containing one or more FBG domains are found universally in vertebrates and invertebrates. In invertebrates, FREPs are involved in immune responses and other aspects of physiology. To understand the complexity of this gene family in Drosophila, we analyzed FREPs in twelve Drosophila species. Results Using the genome data from 12 Drosophila species, we identified FBG domains in each species. The results show that the gene numbers in each species vary from 14 genes up to 43 genes. Using sequence profile analysis, we found that FBG domains have high sequence similarity and are highly conserved throughout. By comparison of structure and sequence conservation, some of the FBG domains in Drosophila melanogaster are predicted to function in recognition of carbohydrates and their derivatives on the surface of microorganisms in innate immunity. Conclusion Sequence and structural analyses show that FREP family across 12 Drosophila species contains conserved FBG domains. Expansion of the FREP families in Drosophila is mainly accounted by a major expansion of FBG domains.

  6. Twelve-Year Trends of PM10 and Visibility in the Hefei Metropolitan Area of China

    Directory of Open Access Journals (Sweden)

    Lin Huang

    2016-01-01

    Full Text Available China has been experiencing severe air pollution and previous studies have mostly focused on megacities and a few hot spot regions. Hefei, the provincial capital city of Anhui province, has a population of near 5 million in its metropolitan area, but its air quality has not been reported in literature. In this study, daily PM10 and visibility data in 2001–2012 were analyzed to investigate the air quality status as well as the twelve-year pollution trends in Hefei. The results reveal that Hefei has been suffering high PM10 pollution and low visibility during the study period. The annual average PM10 concentrations are 2~3 times of the Chinese Ambient Air Quality Standard. PM10 shows fluctuating variation in 2001–2007 and has a slightly decreasing trend after 2008. The annual average visibility range is generally lower than 7 km and shows a worsening trend from 2001 to 2006 followed by an improving trend from 2007 to 2012. Wind speed, precipitation, and relative humidity have negative effects on PM10 concentrations in Hefei, while temperature could positively or negatively affect PM10. The results provide a general understanding of the status and long-term trends of PM10 pollution and visibility in a typical second-tier city in China.

  7. Validation of Twelve Small Kepler Transiting Planets in the Habitable Zone

    CERN Document Server

    Torres, Guillermo; Fressin, Francois; Caldwell, Douglas A; Twicken, Joseph D; Ballard, Sarah; Batalha, Natalie M; Bryson, Stephen T; Ciardi, David R; Henze, Christopher E; Howell, Steve B; Isaacson, Howard T; Jenkins, Jon M; Muirhead, Philip S; Newton, Elisabeth R; Petigura, Erik A; Barclay, Thomas; Borucki, William J; Crepp, Justin R; Everett, Mark E; Horch, Elliott P; Howard, Andrew W; Kolbl, Rea; Marcy, Geoffrey W; McCauliff, Sean; Quintana, Elisa V

    2015-01-01

    We present an investigation of twelve candidate transiting planets from Kepler with orbital periods ranging from 34 to 207 days, selected from initial indications that they are small and potentially in the habitable zone (HZ) of their parent stars. The expected Doppler signals are too small to confirm them by demonstrating that their masses are in the planetary regime. Here we verify their planetary nature by validating them statistically using the BLENDER technique, which simulates large numbers of false positives and compares the resulting light curves with the Kepler photometry. This analysis was supplemented with new follow-up observations (high-resolution optical and near-infrared spectroscopy, adaptive optics imaging, and speckle interferometry), as well as an analysis of the flux centroids. For eleven of them (KOI-0571.05, 1422.04, 1422.05, 2529.02, 3255.01, 3284.01, 4005.01, 4087.01, 4622.01, 4742.01, and 4745.01) we show that the likelihood they are true planets is far greater than that of a false po...

  8. Measurement and analysis of angular velocity variations of twelve-cylinder diesel engine crankshaft

    Science.gov (United States)

    Bulatović, Ž. M.; Štavljanin, M. S.; Tomić, M. V.; Knežević, D. M.; Biočanin, S. Lj.

    2011-11-01

    This paper presents the procedures for measuring and analyzing the angular velocity variation of twelve-cylinder diesel engine crankshaft on its free end and on the power-output end. In addition, the paper deals with important aspects of the measurement of crankshaft torsional oscillations. The method is based on digital encoders placed at two distances, and one of them is a sensor not inserted directly on the shaft, i.e. a non-contact method with a toothed disc is used. The principle based on toothed disc is also used to measure the actual camshaft angular velocity of in-line compact high-pressure pump the engine is equipped with, and this paper aims to demonstrate the possibility of measuring the actual angular velocity of any rotating shaft in the engine, on which it is physically possible to mount a toothed disc. The method was created completely independently during long-range development and research tests of V46 family engines. This method is specific for its particular adaptability for use on larger engines with extensive vibrations and torsional oscillations. The main purpose of this paper is a practical contribution to all the more interesting research of the use of engine crankshaft angular velocity as a diagnostic tool for identifying the engine irregular running.

  9. Access to oral health services in children under twelve years of age in Peru, 2014

    Directory of Open Access Journals (Sweden)

    Akram Hernández-Vásquez

    2016-10-01

    Full Text Available The aim of the study was to explore the patterns of dental health services access in children under twelve years of age in Peru. Data from 25,285 children under 12 years who participated in the Demographic and Family Health Survey of 2014 were reviewed. An exploratory spatial analysis was performed to project the proportions of children with access to dental health services, according to national regions, type of health service and urban or rural place of residence. The results show that of the total sample, 26.7% had access to dental health services in the last six months, 39.6% belonged to the age group 0-4 years, 40.6% lived in the Andean region and 58.3% lived in urban areas. The regions of Huancavelica, Apurimac, Ayacucho, Lima and Pasco had the highest percentages of access nationwide. In conclusion, there is low access to dental health services in the population under 12 years of age in Peru. The spatial distribution of access to dental health services allows regions to be identified and grouped according to similar access patterns, in order to better focus public health actions.

  10. Synergy between Seeking Safety and Twelve-Step Affiliation on Substance Use Outcomes for Women

    Science.gov (United States)

    Morgan-Lopez, Antonio A.; Saavedra, Lissette M.; Hien, Denise A.; Campbell, Aimee N.; Wu, Elwin; Ruglass, Lesia

    2014-01-01

    Objective The Recovery Management paradigm provides a conceptual framework for the examination of joint impact of a focal treatment and post-treatment service utilization on substance abuse treatment outcomes. We test this framework by examining the interactive effects of a treatment for comorbid PTSD and substance use, Seeking Safety, and post-treatment Twelve-Step Affiliation (TSA) on alcohol and cocaine use. Method Data from 353 women in a six-site, randomized controlled effectiveness trial within the NIDA Clinical Trials Network were analyzed under latent class pattern mixture modeling. LCPMM was used to model variation in Seeking Safety by TSA interaction effects on alcohol and cocaine use. Results Significant reductions in alcohol use among women in Seeking Safety (compared to Health Education) were observed; women in the Seeking Safety condition who followed up with TSA had the greatest reductions over time in alcohol use. Reductions in cocaine use over time were also observed but did not differ between treatment conditions nor were there interactions with post-treatment TSA. Conclusions Findings advance understanding of the complexities for treatment and continuing recovery processes for women with PTSD and SUDs, and further support the chronic disease model of addiction. PMID:23558158

  11. Coréia aguda na gravidez Acute chorea in pregnancy: comments on twelve consecutive cases

    Directory of Open Access Journals (Sweden)

    Walter C. Pereira

    1967-12-01

    Full Text Available São apresentados doze casos de coréia aguda observados entre 150.000 gestantes (1/12.500. A maioria dos surtos ocorreu no segundo trimestre da primeira gravidez. A duração média dos sintomas foi de três meses, não tendo sido registrado caso algum de óbito materno. Todos os partos foram espontâneos e normais. Houve apenas um óbito fetal conseqüente a choque hemorrágico. São tecidas considerações a propósito dos aspectos clínico, laboratorial e prognóstico da coréia gravídica, sendo focalizado mais pormenorizadamente o problema fisiopatogênico dessa afecção.Twelve consecutive cases of acute chorea occurring among 150.000 pregnant women (1/12.500 are reported. Most of the cases occurred from the fourth do the sixth month of the first pregnancy. The average duration of the symptoms was of three months and no one case of maternal death was verified in the group. The deliveries were spontaneous and normal in all the patients. Only one case of fetal death occurred in consequence of a hemorragic shock. Comments are made on the clinical, laboratorial and prognostic features of chorea gravidarum, being particulary focused the physiopathogenic problem of this condtion.

  12. Heterochromatic banding patterns on chromosomes of twelve weevil species (Insecta, Coleoptera, Curculionoidea: Apionidae, Curculionidae).

    Science.gov (United States)

    Holecová, Milada; Rozek, Maria; Lachowska, Dorota

    2002-01-01

    The C-banding patterns of twelve weevil species are presented. The obtained results confirm the existence of two groups of species: with a small or large amount of heterochromatin in the karyotype. The first group comprises seven species (Apionidae: Holotrichapion pisi; Curculionidae: Phyllobius urticae, Ph. pyri, Ph. maculicornis, Tanymecus palliatus, Larinodontes turbinatus, Cionus tuberculosus). In weevils with a small amount of heterochromatin, tiny grains on the nucleus in interphase are visible, afterwards in mitotic and meiotic prophase appearing as dark dots. The absence of C-bands does not indicate a lack of heterochromatin but heterochromatic regions are sometimes so small that the condensation is not visible during the cell cycle. The second group comprises five species (Otiorhynchus niger, O. morio, Polydrusus corruscus, Barypeithes chevrolati, Nedyus quadrimaculatus) which possess much larger heteropicnotic parts of chromosomes visible during all nuclear divisions. The species examined have paracentromeric C-bands on autosomes and the sex chromosome X, except for Otiorhynchus niger, which also has an intercalary bands on one pair of autososomes. All the species examined differ in the size of segments of constitutive heterochromatin. The y heterochromosome is dot-like and wholly euchromatic in all the studied species.

  13. In vitro antibacterial and antifungal activities of twelve sponges collected from the Anambas Islands, Indonesia

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    Masteria Yunovilsa Putra

    2016-09-01

    Full Text Available Objective: To evaluate antimicrobial activities in methanolic extracts of twelve sponges collected from the Anambas Islands, Indonesia. Methods: The antibacterial activity of methanolic extracts was tested against two Grampositive bacteria, viz. Bacillus subtilis (ATCC 6633 and Staphylococcus aureus (ATCC 25923, and two Gram-negative bacteria, viz. Eschericia coli (ATCC 25922 and Vibrio anguillarum (ATCC 19264 using the disk diffusion assay. The antifungal activity was similarly tested against Candida albicans (ATCC 10231 and Aspergillus niger (ATCC 16404. The minimum inhibitory concentrations of promising sponges extracts were determined by the microdilution technique. Results: All the sponge species in this study showed antimicrobial activities against at least one of the test strains. Antibacterial activities were observed in 66.7% of the sponges extracts, while 30.0% of the extracts exhibited antifungal activities. Among them, the extracts of the sponges Stylissa massa and Axinyssa sp. were the most active against four tested bacteria and the yeast Candida albicans. The sponge Theonella swinhoei and two species of Xestospongia also displayed significant activities against two fungal pathogens Candida albicans and Aspergillus niger. Conclusions: Antimicrobial activities were demonstrated in extracts from various marine sponges collected from the Anambas Islands, Indonesia. The most promising sponges among them were Stylissa massa and Axinyssa sp. This is the first report of antimicrobial activity in extracts of marine sponges from the Indonesian Anambas Islands.

  14. The SLUGGS Survey: Kinematics for over 2500 Globular Clusters in Twelve Early-type Galaxies

    CERN Document Server

    Pota, Vincenzo; Romanowsky, Aaron J; Brodie, Jean P; Spitler, Lee R; Strader, Jay; Foster, Caroline; Arnold, Jacob A; Benson, Andrew; Blom, Christina; Hargis, Jonathan R; Rhode, Katherine L; Usher, Christopher

    2012-01-01

    We present a spectro-photometric survey of 2522 extragalactic globular clusters (GCs) around twelve early-type galaxies, nine of which have not been published previously. Combining space-based and multi-colour wide field ground-based imaging, with spectra from the Keck DEIMOS instrument, we obtain an average of 160 GC radial velocities per galaxy, with a high velocity precision of 15 km/s per GC. After studying the photometric properties of the GC systems, such as their spatial and colour distributions, we focus on the kinematics of metal-poor (blue) and metal-rich (red) GC subpopulations to an average distance of ~8 effective radii from the galaxy centre. Our results show that for some systems the bimodality in GC colour is also present in GC kinematics. The kinematics of the red GC subpopulations are strongly coupled with the host galaxy stellar kinematics. The blue GC subpopulations are more dominated by random motions, especially in the outer regions, and decoupled from the red GCs. Peculiar GC kinematic ...

  15. Interaction and cooperative effort among scientific societies. Twelve years of COSCE.

    Science.gov (United States)

    Martín, Nazario; Andradas, Carlos

    2015-12-01

    The evolution of knowledge and technology in recent decades has brought profound changes in science policy, not only in the countries but also in the supranational organizations. It has been necessary, therefore, to adapt the scientific institutions to new models in order to achieve a greater and better communication between them and the political counterparts responsible for defining the general framework of relations between science and society. The Federationon of Scientific Societies of Spain (COSCE, Confederación de Sociedades Científicas de España) was founded in October 2003 to respond to the urgent need to interact with the political institutions and foster a better orientation in the process of making decisions about the science policy. Currently COSCE consists of over 70 Spanish scientific societies and more than 40,000 scientists. During its twelve years of active life, COSCE has developed an intense work of awareness of the real situation of science in Spain by launching several initiatives (some of which have joined other organizations) or by joining initiatives proposed from other groups related to science both at the Spanish level and at the European and non-European scenarios. [Int Microbiol 18(4): 245-251 (2015)].

  16. Ecological conversion efficiency and its influencers in twelve species of fish in the Yellow Sea Ecosystem

    Science.gov (United States)

    Tang, Qisheng; Guo, Xuewu; Sun, Yao; Zhang, Bo

    2007-09-01

    The ecological conversion efficiencies in twelve species of fish in the Yellow Sea Ecosystem, i.e., anchovy ( Engraulis japonicus), rednose anchovy ( Thrissa kammalensis), chub mackerel ( Scomber japonicus), halfbeak ( Hyporhamphus sajori), gizzard shad ( Konosirus punctatus), sand lance ( Ammodytes personatus), red seabream ( Pagrus major), black porgy ( Acanthopagrus schlegeli), black rockfish ( Sebastes schlegeli), finespot goby ( Chaeturichthys stigmatias), tiger puffer ( Takifugu rubripes), and fat greenling ( Hexagrammos otakii), were estimated through experiments conducted either in situ or in a laboratory. The ecological conversion efficiencies were significantly different among these species. As indicated, the food conversion efficiencies and the energy conversion efficiencies varied from 12.9% to 42.1% and from 12.7% to 43.0%, respectively. Water temperature and ration level are the main factors influencing the ecological conversion efficiencies of marine fish. The higher conversion efficiency of a given species in a natural ecosystem is acquired only under the moderate environment conditions. A negative relationship between ecological conversion efficiency and trophic level among ten species was observed. Such a relationship indicates that the ecological efficiency in the upper trophic levels would increase after fishing down marine food web in the Yellow Sea ecosystem.

  17. Alcoholics Anonymous and twelve-step recovery: a model based on social and cognitive neuroscience.

    Science.gov (United States)

    Galanter, Marc

    2014-01-01

    In the course of achieving abstinence from alcohol, longstanding members of Alcoholics Anonymous (AA) typically experience a change in their addiction-related attitudes and behaviors. These changes are reflective of physiologically grounded mechanisms which can be investigated within the disciplines of social and cognitive neuroscience. This article is designed to examine recent findings associated with these disciplines that may shed light on the mechanisms underlying this change. Literature review and hypothesis development. Pertinent aspects of the neural impact of drugs of abuse are summarized. After this, research regarding specific brain sites, elucidated primarily by imaging techniques, is reviewed relative to the following: Mirroring and mentalizing are described in relation to experimentally modeled studies on empathy and mutuality, which may parallel the experiences of social interaction and influence on AA members. Integration and retrieval of memories acquired in a setting like AA are described, and are related to studies on storytelling, models of self-schema development, and value formation. A model for ascription to a Higher Power is presented. The phenomena associated with AA reflect greater complexity than the empirical studies on which this article is based, and certainly require further elucidation. Despite this substantial limitation in currently available findings, there is heuristic value in considering the relationship between the brain-based and clinical phenomena described here. There are opportunities for the study of neuroscientific correlates of Twelve-Step-based recovery, and these can potentially enhance our understanding of related clinical phenomena. © American Academy of Addiction Psychiatry.

  18. Fate of the conformal fixed point with twelve massless fermions and SU(3) gauge group

    Science.gov (United States)

    Fodor, Zoltan; Holland, Kieran; Kuti, Julius; Mondal, Santanu; Nogradi, Daniel; Wong, Chik Him

    2016-11-01

    We report new results on the conformal properties of an important strongly coupled gauge theory, a building block of composite Higgs models beyond the Standard Model. With twelve massless fermions in the fundamental representation of the SU(3) color gauge group, an infrared fixed point (IRFP) of the β -function was recently reported in the theory [A. Cheng, A. Hasenfratz, Y. Liu, G. Petropoulos, and D. Schaich, J. High Energy Phys. 05 (2014) 137] with uncertainty in the location of the critical gauge coupling inside the narrow [6.0 fixed point and scale invariance in the theory with model-building implications. Using the exact same renormalization scheme as the previous study, we show that no fixed point of the β -function exists in the reported interval. Our findings eliminate the only seemingly credible evidence for conformal fixed point and scale invariance in the Nf=12 model whose infrared properties remain unresolved. The implications of the recently completed 5-loop QCD β -function for arbitrary flavor number are discussed with respect to our work.

  19. Improving Comparability Of Survey Results Through Ex-Post Harmonisation A Case Study With Twelve European National Travel Surveys

    DEFF Research Database (Denmark)

    Christensen, Linda; Hubert, Jean-Paul; Järvi, Tuuli

    that reflect behavioural differences rather than methodological ones, in the context of the COST Action SHANTI (Survey Harmonisation with New Technologies Improvement, TUD0804) an ex-post harmonisation approach was developed using microdata from twelve European NTS’s. The paper presents both concept and basic...

  20. Relative peripheral refraction in children: twelve-month changes in eyes with different ametropias.

    Science.gov (United States)

    Lee, Tsui-Tsui; Cho, Pauline

    2013-05-01

    To determine the peripheral refraction of children with different types of ametropias and to evaluate the relationship between central refractive changes, baseline relative peripheral refraction (RPR) and changes in RPR over a 12-month monitoring period. Cycloplegic central and peripheral refraction were performed biannually on the right eyes of children aged 6-9 for 12 months, using an open-view autorefractor. Peripheral refraction were measured along 10°, 20° and 30° from central fixation in both nasal and temporal fields. Refractive data were transposed into M, J0 and J45 vectors for analyses. RPR was determined by subtracting the central measurement from each peripheral measurement. Hyperopic eyes showed relative peripheral myopia while myopic eyes had relative hyperopia across the central 60° horizontal field at baseline. Emmetropic eyes had relative myopia within but showed relative hyperopia beyond the central 30° field. However, there was no significant correlation between central refractive changes and baseline RPR or between changes in central refraction and RPR over twelve months in any refractive groups. Correlations between changes in PR and central myopic shift were found mainly in the nasal field in different groups. In the subgroup analysis on the initially emmetropic and the initially myopic groups, the subgroups with faster myopic progression did not have significantly different RPR from the subgroups with slower progression. The RPR pattern of the initially emmetropic and the initially myopic groups became more asymmetric at the end of the study period with a larger increase in relative hyperopia in the temporal field. RPR patterns were different among hyperopic, emmetropic and myopic eyes. However, baseline RPR and changes in RPR cannot predict changes in central refraction over time. Our results did not provide evidence to support the hypothesis of RPR as a causative factor for myopic central refractive changes in children. Ophthalmic

  1. Computational study of the structural and vibrational properties of ten and twelve vertex closo-carboranes

    Energy Technology Data Exchange (ETDEWEB)

    Salam, A.; Deleuze, M.S.; Francois, J.-P

    2003-01-01

    Calculations using ab initio Hartree-Fock and Density Functional theories, the latter employing the B3LYP functional, in combination with a number of large standard basis sets ranging from 6-31G** to cc-pVDZ, have been performed on a series of ten and twelve vertex closo-carborane isomer species. Results obtained for optimized structural parameters and molecular properties are presented for 1,2-, 1,6- and 1,10-C{sub 2}B{sub 8}H{sub 10} and 1,2-, 1,7- and 1,12-C{sub 2}B{sub 10}H{sub 12} and compared, where possible, with both earlier theoretical data and experiment. Irrespective of the model chemistry chosen, the para-isomer in each class of carborane cluster is found to be the most stable species, corresponding to a structure in which the cage carbon atoms are positioned at diametrically opposed ends of the respective polyhedron. Boron-hydrogen and carbon-hydrogen bond lengths are found to change little on going from isomers of one particular cage size to another, supporting analogous conclusions previously established for small closo-carborane cages possessing five, six and seven vertices. The calculated vibrational spectra of the isomers of both decacarborane and dodecacarborane are seen to be similar to each other and reflect a high degree of rigidity within each cluster. Key polyhedral skeletal breathing modes along with characteristic boron-hydrogen and carbon-hydrogen stretching frequencies are identified in the spectra and compared with experiment. Thermochemical data relating to each species are also analyzed.

  2. Indifference to pain syndrome in a twelve-year-old boy (case report

    Directory of Open Access Journals (Sweden)

    Baghdadi T

    2007-08-01

    Full Text Available Background: People vary greatly in their response to painful stimuli, from those with a low pain threshold to those with indifference to pain. However, insensitivity to pain is a rare disorder, characterized by the lack of usual subjective and objective responses to noxious stimuli. Patients who have congenital indifference to pain sustain painless injuries beginning in infancy, but have sensory responses that are otherwise normal on examination. Perception of passive movement, joint position, and vibration is normal in these patients, as are tactile thresholds and light touch perception. Case report: A twelve-year-old boy was admitted to the hospital for a painless deformity, degeneration in both knees and a neglected femoral neck fracture that was inappropriately painless. Further examination revealed normal sensory responses, perception of passive movement, joint position, vibration tactile thresholds and light touch perception. Spinal cord and brain MRI were normal as was the electromyography and nerve conduction velocity (EMG/NCV examination. There was no positive family history for this disorder. Conclusion: The deficits present in the different pain insensitivity syndromes provide insight into the complex anatomical and physiological nature of pain perception. Reports on pain asymbolia, in which pain is perceived but does not cause suffering, and related cortical conditions illustrate that there can be losses that independently involve either the sensory-discriminative component or the affective-motivational component of pain perception, thus highlighting their different anatomical localization. The paucity of experience with this entity and the resultant diagnostic problems, the severity of the associated disabling arthropathy and underscore the importance of this case report of indifference to pain.

  3. Removal of trace level amounts of twelve sulfonamides from drinking water by UV-activated peroxymonosulfate.

    Science.gov (United States)

    Cui, Changzheng; Jin, Lei; Jiang, Lei; Han, Qi; Lin, Kuangfei; Lu, Shuguang; Zhang, Dong; Cao, Guomin

    2016-12-01

    Trace levels of residual antibiotics in drinking water may threaten public health and become a serious problem in modern society. In this work, we investigated the degradation of twelve sulfonamides (SAs) at environmentally relevant trace level concentrations by three different methods: ultraviolet (UV) photolysis, peroxymonosulfate (PMS) oxidation, and UV-activated PMS (UV/PMS). Sulfaguanidine, sulfadiazine, sulfamerazine, sulfamethazine, sulfathiazole, sulfamethoxydiazine, and sulfadimethoxine were be effectively removed by direct UV photolysis and PMS oxidation. However, sulfanilamide, sulfamethizole, sulfamethoxazole, sulfisoxazole, and sulfachloropyridazine were not completely degraded, despite prolonging the UV irradiation time to 30min or increasing the PMS concentration to 5.0mg·L(-1). UV/PMS provided more thorough elimination of SAs, as demonstrated by the complete removal of 200ng·L(-1) of all SAs within 5min at an initial PMS concentration of 1.0mg·L(-1). UV/PMS promoted SA decomposition more efficiently than UV photolysis or PMS oxidation alone. Bicarbonate concentration and pH had a negligible effect on SA degradation by UV/PMS. However, humic acid retarded the process. Removal of 200ng·L(-1) of each SA from a sample of sand-filtered effluent from a drinking water treatment plant (DWTPs) was quickly and completely achieved by UV/PMS. Meanwhile, about 41% of the total organic carbon (TOC) was eliminated. Scavenging experiments showed that sulfate radical (SO4(-)) was the predominant species involved in the degradation. It is concluded that UV/PMS is a rapid and efficient method for removing trace-level SAs from drinking water. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Characterizing gene-gene interactions in a statistical epistasis network of twelve candidate genes for obesity.

    Science.gov (United States)

    De, Rishika; Hu, Ting; Moore, Jason H; Gilbert-Diamond, Diane

    2015-01-01

    Recent findings have reemphasized the importance of epistasis, or gene-gene interactions, as a contributing factor to the unexplained heritability of obesity. Network-based methods such as statistical epistasis networks (SEN), present an intuitive framework to address the computational challenge of studying pairwise interactions between thousands of genetic variants. In this study, we aimed to analyze pairwise interactions that are associated with Body Mass Index (BMI) between SNPs from twelve genes robustly associated with obesity (BDNF, ETV5, FAIM2, FTO, GNPDA2, KCTD15, MC4R, MTCH2, NEGR1, SEC16B, SH2B1, and TMEM18). We used information gain measures to identify all SNP-SNP interactions among and between these genes that were related to obesity (BMI > 30 kg/m(2)) within the Framingham Heart Study Cohort; interactions exceeding a certain threshold were used to build an SEN. We also quantified whether interactions tend to occur more between SNPs from the same gene (dyadicity) or between SNPs from different genes (heterophilicity). We identified a highly connected SEN of 709 SNPs and 1241 SNP-SNP interactions. Combining the SEN framework with dyadicity and heterophilicity analyses, we found 1 dyadic gene (TMEM18, P-value = 0.047) and 3 heterophilic genes (KCTD15, P-value = 0.045; SH2B1, P-value = 0.003; and TMEM18, P-value = 0.001). We also identified a lncRNA SNP (rs4358154) as a key node within the SEN using multiple network measures. This study presents an analytical framework to characterize the global landscape of genetic interactions from genome-wide arrays and also to discover nodes of potential biological significance within the identified network.

  5. Thermal environment in eight low-energy and twelve conventional Finnish houses.

    Science.gov (United States)

    Kähkönen, Erkki; Salmi, Kari; Holopainen, Rauno; Pasanen, Pertti; Reijula, Kari

    2015-11-01

    We assessed the thermal environment of eight recently built low-energy houses and twelve conventional Finnish houses. We monitored living room, bedroom and outdoor air temperatures and room air relative humidity from June 2012 to September 2013. Perceived thermal environment was evaluated using a questionnaire survey during the heating, cooling and interim seasons. We compared the measured and perceived thermal environments of the low-energy and conventional houses. The mean air temperature was 22.8 °C (21.9-23.8 °C) in the low-energy houses, and 23.3 °C (21.4-26.5 °C) in the conventional houses during the summer (1. June 2013-31. August 2013). In the winter (1. December 2012-28. February 2013), the mean air temperature was 21.3 °C (19.8-22.5 °C) in the low-energy houses, and 21.6 °C (18.1-26.4 °C) in the conventional houses. The variation of the air temperature was less in the low-energy houses than that in the conventional houses. In addition, the occupants were on average slightly more satisfied with the indoor environment in the low-energy houses. However, there was no statistically significant difference between the mean air temperature and relative humidity of the low-energy and conventional houses. Our measurements and surveys showed that a good thermal environment can be achieved in both types of houses.

  6. Phytochemical screening of twelve species of phytoplankton isolated from Arabian Sea coast

    Directory of Open Access Journals (Sweden)

    Sushanth Vishwanath Rai

    2015-11-01

    Full Text Available Objective: To analyze the phytochemicals in twelve species of marine phytoplankton. Methods: Total phenolic content of methanol extract was estimated by the Folin-Ciocalteu method. Total flavonoid content of the methanol extarct was determined by aluminium chloride method. Chlorophylls, β-carotene and astaxanthin were estimated by acetone extraction method. Vitamin C was determined by dinitrophenyl-hydrazine method. Phycobiliproteins such as allophycocyanin, phycocyanin and phycoerythrin in the aqueous extracts were determined. Results: Total phenolics varied from 5.41 mg gallic acid equivalents/g dry weight (DW in Phormidium corium (P. corium to 17.37 mg gallic acid equivalents/g DW in Oscillatoria fremyii (O. fremyii. Total flavonoids ranged between 0.74 mg quercetin equivalent/g DW in P. corium and 9.87 mg quercetin equivalent/g DW in Nannochloropsis oceanica. Chlorophyll-a pigment was high in Chaetoceros calcitrans (C. calcitrans (15.51 mg/g DW and low in P. corium (1.08 mg/g DW. Chlorophyll-c ranged between 0.07 mg/g DW in Nannochloropsis oceanica and 4.62 mg/g DW in C. calcitrans. High contents of β-carotene and astaxanthin were found in C. calcitrans and low in P. corium which ranged from 0.33 to 10.03 mg/g DW and 0.18 to 3.85 mg/g DW, respectively. Vitamin C content varied from 0.50 mg/g DW in C. calcitrans to 1.51 mg/g DW in Phormidium tenue. O. fremyii showed highest total phycobiliproteins of 317.05 mg/g DW. High contents of allophycocyanin and phycocyanin were found in O. fremyii, whereas high contents of phycoerythrin were found in Oscillatoria sancta. All the three phycobiliproteins were low in Chroococcus turgidus. Conclusions: Marine phytoplankton are one of the natural sources providing novel biologically active compounds with potential for pharmaceutical applications.

  7. Phytochemical screening of twelve species of phytoplankton isolated from Arabian Sea coast

    Institute of Scientific and Technical Information of China (English)

    Sushanth Vishwanath Rai; Madaiah Rajashekhar

    2015-01-01

    Objective:To analyze the phytochemicals in twelve species of marine phytoplankton. Methods: Total phenolic content of methanol extract was estimated by the Folin-Ciocalteu method. Total flavonoid content of the methanol extarct was determined by aluminium chloride method. Chlorophylls,β-carotene and astaxanthin were estimated by acetone extraction method. Vitamin C was determined by dinitrophenyl-hydrazine method. Phycobiliproteins such as allophycocyanin, phycocyanin and phycoerythrin in the aqueous extracts were determined. Results: Total phenolics varied from 5.41 mg gallic acid equivalents/g dry weight (DW) in Phormidium corium (P. corium) to 17.37 mg gallic acid equivalents/g DW inOscillatoria fremyii(O. fremyii). Total flavonoids ranged between 0.74 mg quercetin equivalent/g DW inP. corium and 9.87 mg quercetin equivalent/g DW inNannochloropsis oceanica. Chlorophyll-a pigment was high inChaetoceros calcitrans(C. calcitrans)(15.51 mg/g DW) and low inP. corium (1.08 mg/g DW). Chlorophyll-c ranged between 0.07 mg/g DW inNannochloropsis oceanica and 4.62 mg/g DW inC. calcitrans. High contents ofβ-carotene and astaxanthin were found inC. calcitrans and low inP. corium which ranged from 0.33 to 10.03 mg/g DW and 0.18 to 3.85 mg/g DW, respectively. Vitamin C content varied from 0.50 mg/g DW inC. calcitrans to 1.51 mg/g DW inPhormidium tenue.O. fremyii showed highest total phycobiliproteins of 317.05 mg/g DW. High contents of allophycocyanin and phycocyanin were found inO. fremyii, whereas high contents of phycoerythrin were found inOscillatoria sancta. All the three phycobiliproteins were low inChroococcus turgidus. Conclusions: Marine phytoplankton are one of the natural sources providing novel biologically active compounds with potential for pharmaceutical applications.

  8. Molecular phylogenetic systematics of twelve species of Acipenseriformes based on mtDNA ND4L -ND4 gene sequence analysis

    Institute of Scientific and Technical Information of China (English)

    张四明; 张亚平; 郑向忠; 陈永久; 邓怀; 汪登强; 危起伟; 张云武; 聂龙; 吴清江

    2000-01-01

    Acipenseriformes is an endangered primitive fish group, which occupies a special place in the history of ideas concerning fish evolution, even in vertebrate evolution. However, the classification and evolution of the fishes have been debated. The mitochondrial DMA (mtDNA) ND4L and partial A7D4 genes were first sequenced in twelve species of the order Acipenseriformes, including endemic Chinese species. The following points were drawn from DNA sequences analysis: (i) the two species of Huso can be ascribed to Acipenser; (ii) A. dabryanus is the mostly closely related to A. sinensis, and most likely the landlocked form of A. sinensis; (iii) genus Acipenser in trans-Pacific region might have a common origin; (iv) mtDNA ND4L and ND4 genes are the ideal genetic markers for phylogenetic analysis of the order Acipenseriformes.

  9. Molecular phylogenetic systematics of twelve species of Acipenseriformes based on mtDNA ND4L -ND4 gene sequence analysis

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Acipenseriformes is an endangered primitive fish group, which occupies a special place in the history of ideas concerning fish evolution, even in vertebrate evolution. However, the classification and evolution of the fishes have been debated. The mitochondrial DNA (mtDNA) ND4L and partial ND4 genes were first sequenced in twelve species of the order Acipenseriformes, including endemic Chinese species. The following points were drawn from DNA sequences analysis: (i) the two species of Huso can be ascribed to Acipenser; (ii) A. dabryanus is the mostly closely related to A. sinensis, and most likely the landlocked form of A. sinensis; (iii) genus Acipenser in trans-Pacific region might have a common origin; (iv) mtDNA ND4L and ND4 genes are the ideal genetic markers for phylogenetic analysis of the order Acipenseriformes.

  10. Analyses of Twelve New Whole Genome Sequences of Cassava Brown Streak Viruses and Ugandan Cassava Brown Streak Viruses from East Africa: Diversity, Supercomputing and Evidence for Further Speciation.

    Directory of Open Access Journals (Sweden)

    Joseph Ndunguru

    Full Text Available Cassava brown streak disease is caused by two devastating viruses, Cassava brown streak virus (CBSV and Ugandan cassava brown streak virus (UCBSV which are frequently found infecting cassava, one of sub-Saharan Africa's most important staple food crops. Each year these viruses cause losses of up to $100 million USD and can leave entire families without their primary food source, for an entire year. Twelve new whole genomes, including seven of CBSV and five of UCBSV were uncovered in this research, doubling the genomic sequences available in the public domain for these viruses. These new sequences disprove the assumption that the viruses are limited by agro-ecological zones, show that current diagnostic primers are insufficient to provide confident diagnosis of these viruses and give rise to the possibility that there may be as many as four distinct species of virus. Utilizing NGS sequencing technologies and proper phylogenetic practices will rapidly increase the solution to sustainable cassava production.

  11. Age Distribution of Influenza Like Illness Cases during Post-Pandemic A(H3N2): Comparison with the Twelve Previous Seasons, in France

    Science.gov (United States)

    Turbelin, Clément; Souty, Cécile; Pelat, Camille; Hanslik, Thomas; Sarazin, Marianne; Blanchon, Thierry; Falchi, Alessandra

    2013-01-01

    In France, the 2011–2012 influenza epidemic was characterized by the circulation of antigenically drifted influenza A(H3N2) viruses and by an increased disease severity and mortality among the elderly, with respect to the A(H1N1)pdm09 pandemic and post-pandemic outbreaks. Whether the epidemiology of influenza in France differed between the 2011–2012 epidemic and the previous outbreaks is unclear. Here, we analyse the age distribution of influenza like illness (ILI) cases attended in general practice during the 2011–2012 epidemic, and compare it with that of the twelve previous epidemic seasons. Influenza like illness data were obtained through a nationwide surveillance system based on sentinel general practitioners. Vaccine effectiveness was also estimated. The estimated number of ILI cases attended in general practice during the 2011–2012 was lower than that of the past twelve epidemics. The age distribution was characteristic of previous A(H3N2)-dominated outbreaks: school-age children were relatively spared compared to epidemics (co-)dominated by A(H1N1) and/or B viruses (including the 2009 pandemic and post-pandemic outbreaks), while the proportion of adults over 30 year-old was higher. The estimated vaccine effectiveness (54%, 95% CI (48, 60)) was in the lower range for A(H3N2) epidemics. In conclusion, the age distribution of ILI cases attended in general practice seems to be not different between the A(H3N2) pre-pandemic and post-pandemic epidemics. Future researches including a more important number of ILI epidemics and confirmed virological data of influenza and other respiratory pathogens are necessary to confirm these results. PMID:23755294

  12. The Impact of the Financial Crisis on the Content of Twelve Bestselling US Principles of Economics Textbooks

    DEFF Research Database (Denmark)

    Madsen, Poul Thøis

    2013-01-01

    How have authors of twelve bestselling introductory US textbooks in economics responded to the traumatizing financial crisis? In general the financial crisis is described with a couple of lines here and there or it is dealt with in boxes, separate sections, or specific isolated chapters. Some...... of the textbooks distinguish themselves by also having made some modest qualitative changes of content as a reaction to the financial crisis (especially Colander 2010 and Krugman and Wells 2013). Applying my general analysis of the changes being made already in the twelve textbooks seen as a whole, I discuss how...... any introductory textbook could integrate the financial crisis more adequately into the general presentation, thereby hopefully contributing to enhancing the interest of the students....

  13. A retrospective evaluation of the quality of malaria case management at twelve health facilities in four districts in Zambia

    Institute of Scientific and Technical Information of China (English)

    Pascalina Chanda-Kapata; Emmanuel Chanda; Freddie Masaninga; Annette Habluetzel; Felix Masiye; Ibrahima Soce Fall

    2014-01-01

    Objective: To establish the appropriateness of malaria case management at health facility level in four districts in Zambia. Methods: This study was a retrospective evaluation of the quality of malaria case management at health facilities in four districts conveniently sampled to represent both urban and rural settings in different epidemiological zones and health facility coverage. The review period was from January to December 2008. The sample included twelve lower level health facilities from four districts. The Pearson Chi-square test was used to identify characteristics which affected the quality of case management.Results:Out of 4891 suspected malaria cases recorded at the 12 health facilities, more than 80% of the patients had a temperature taken to establish their fever status. About 67% (CI95 66.1-68.7) were tested for parasitemia by either rapid diagnostic test or microscopy, whereas the remaining 22.5% (CI95 21.3.1-23.7) were not subjected to any malaria test. Of the 2247 malaria cases reported (complicated and uncomplicated), 71% were parasitologically confirmed while 29% were clinically diagnosed (unconfirmed). About 56% (CI95 53.9-58.1) of the malaria cases reported were treated with artemether-lumefantrine (AL), 35% (CI95 33.1-37.0) with sulphadoxine-pyrimethamine, 8% (CI95 6.9-9.2) with quinine and 1% did not receive any anti-malarial. Approximately 30% of patients WHO were found negative for malaria parasites were still prescribed an anti-malarial, contrary to the guidelines. There were marked inter-district variations in the proportion of patients in WHOm a diagnostic tool was used, and in the choice of anti-malarials for the treatment of malaria confirmed cases. Association between health worker characteristics and quality of case malaria management showed that nurses performed better than environmental health technicians and clinical officers on the decision whether to use the rapid diagnostic test or not. Gender, in service training on malaria

  14. RUGBY GAME-RELATED STATISTICS THAT DISCRIMINATE BETWEEN WINNING AND LOSING TEAMS IN IRB AND SUPER TWELVE CLOSE GAMES

    Directory of Open Access Journals (Sweden)

    Luis Vaz

    2010-03-01

    Full Text Available The aim of the current study was to identify the Rugby game- related statistics that discriminated between winning and losing teams in IRB and S12 close games. Archival data reported to game-related statistics from 120 IRB games and 204 Super Twelve games played between 2003 and 2006. Afterwards, a cluster analysis was conducted to establish, according to game final score differences, three different match groups. Only the close games group was selected for further analysis (IRB n = 64 under 15 points difference and Super Twelve n = 95 under 11 points difference. An analysis to the structure coefficients (SC obtained through a discriminant analysis allowed to identify the most powerful game-related statistics in discriminating between winning and losing teams. The discriminant functions were statistically significant for Super Twelve games (Chi-square = 33.8, p < 0.01, but not for IRB games (Chi- square = 9.4, p = n.s.. In the first case, winners and losers were discriminated by possessions kicked (SC = 0.48, tackles made (SC = 0.45, rucks and pass (SC = -0.40, passes completed (SC = 0. 39, mauls won (SC = -0.36, turnovers won (SC = -0.33, kicks to touch (SC = 0.32 and errors made (SC = -0.32. The minus sign denotes higher values in losing teams. Rugby game-related statistics were able to discriminate between winners and losers in Super Twelve close games and suggest that a kicking based game supported by an effective defensive structure is more likely to win matches than a possession based one

  15. Radicular anatomy of twelve representatives of the Catasetinae subtribe (Orchidaceae: Cymbidieae

    Directory of Open Access Journals (Sweden)

    Cristiano Pedroso-de-Moraes

    2012-06-01

    Full Text Available Considering that the root structure of the Brazilian genera belonging to the Catasetinae subtribe is poorly known, we describe the roots of twelve representatives from this subtribe. For anatomical analysis, the roots were fixed in FAA 50, preserved in ethanol 70% and sectioned at its medium region using razor blades. The sections were stained with 0.05% astra blue and safranin and mounted in glycerin. For the identification of starch we used Lugol's solution; for lignin, floroglucin chloridric; for lipids, Sudan III, and for flavanoids, potassium hydroxide. The relevant aspects were registered using a digital camera joined with an Olympus microspope (BX51 model. The structural similarities of all roots support the placement of the subtribe Catasetinae into the monophyletic tribe Cymbidieae. Some root features are restricted to one or two taxa and can be useful in the systematics of the subtribe. For example, the occurrence of flavonoidic crystals characterizes the genera Catasetum and Cychnodes, and the number of the velamen layers and the shape of the epivelamen cells are useful to confirm the taxonomic position of Clowesia amazonica. The presence of velamen and flavonoidic crystals was interpreted as an adaptation to the epiphytic habit.Considerando que a estrutura das raízes de gêneros brasileiros pertencentes à subtribo Catasetinae é pouco conhecida, descrevemos as raízes de doze representantes desta subtribo. Para análise anatômica, as raízes foram fixadas em FAA 50, preservadas em álcool 70% e seccionadas na sua região média usando lâminas de barbear. Os cortes foram corados com astra blue e Safrablau 0,05% e montados em glicerina. Para a identificação do amido, utilizou-se a solução de Lugol; da lignina, floroglucina clorídrica, dos lipídios, Sudan III e dos flavonóides, hidróxido de potássio. Os aspectos relevantes foram registrados usando câmera digital acoplada a um microscópio Olympus (modelo BX51. As semelhan

  16. Guidelines for Professional Referral to Alcoholics Anonymous and Other Twelve Step Groups.

    Science.gov (United States)

    Riordan, Richard J.; Walsh, Lani

    1994-01-01

    Reviews 12-step programs, focusing on Alcoholics Anonymous (AA), the oldest and largest 12-step group. Explores criticisms of AA, describes its components and mechanics, and provides guidelines for client referral. Includes 28 citations. (Author/CRR)

  17. Twelve invasive plant taxa in U.S. western riparian ecosystems

    Science.gov (United States)

    Assessments of stream ecosystems often include an evaluation of riparian condition; a key stressor in riparian ecosystems is the presence of invasive plants. We analyzed the distribution of 12 invasive taxa (common burdock [Arctium minus], giant reed [Arundo donax], cheatgrass [B...

  18. Twelve Activities for Teaching the Pragmatics of Complaining to L2 Learners

    Science.gov (United States)

    Hilliard, Amanda

    2017-01-01

    Pragmatic competence, or the ability to use language appropriately in a variety of contexts, is a critical skill for communication in a second language (L2). Thus, teaching that focuses on developing students' abilities to communicate effectively in an L2 must also include a focus on developing students' pragmatic competence. This article…

  19. Twelve Commandments of Human Relations for the Diverse Academic Environment of Colleges and Universities

    Science.gov (United States)

    Davis, William Young; Swartz, Caroline

    2008-01-01

    This paper focuses on applying proven industrial relations approaches and sound management practice to address a range of diversity issues in higher education. Issues addressed include the need to set a clear and consistent direction, the importance of effective policy setting and enforcement, the value of positive reinforcement, and the…

  20. Theory including future not excluded

    DEFF Research Database (Denmark)

    Nagao, K.; Nielsen, H.B.

    2013-01-01

    We study a complex action theory (CAT) whose path runs over not only past but also future. We show that, if we regard a matrix element defined in terms of the future state at time T and the past state at time TA as an expectation value in the CAT, then we are allowed to have the Heisenberg equation......, Ehrenfest's theorem, and the conserved probability current density. In addition,we showthat the expectation value at the present time t of a future-included theory for large T - t and large t - T corresponds to that of a future-not-included theory with a proper inner product for large t - T. Hence, the CAT...

  1. The Effect o f Twelve - Week Recreation Act i v ities on the Anxiety Level of Female Pri soners

    Directory of Open Access Journals (Sweden)

    Zekiye B AŞARAN

    2015-07-01

    Full Text Available T h e a i m o f t h e s t u d y w a s to examine the effect of twelve - weeks recreation activities on the trait anxiety level of female prisoners in the prisons. The sampling of this study consists of 45 female prisoners who are in the Open Prison in Kandira, 22 of whom are in the experimental group and 23 of whom are in the control group. Different activities, such as music, dance, meditatio n, sportive activities, movies and videos, fun and entertainment activities and competitions, were performed one and half hours a day and two days a week. This lasted for twelve weeks. The data were collected by pre - tests and post - tests that were given bo th at the beginning and at the end of this program. Personal information form and Spielberger anxiety inventory were used as the data collecting tool. The reliability coefficient (Cronbach Alpha was calculated as ,873. The data were analysed with SPSS Win dows 18 programme. Descriptive statistics and Wilcoxon test were conducted. A si gnificant statistical correlation was determined between the prisoners’ pre - tests and post - tests scores in the experimental group (p <0.05. A s c o n c l u s i o n , a positive impact on trait anxiety levels of prisoners w a s f o u n d a f t e r 12 weeks o f recreational activities.

  2. Risk assessment of K basin twelve-inch drain valve failure from a postulated seismic initiating event

    Energy Technology Data Exchange (ETDEWEB)

    MORGAN, R.G.

    1999-04-06

    The Spent Nuclear Fuel (SNF) Project will transfer metallic SNF from the Hanford 105 K-East and 105 K-West Basins to safe interim storage in the Canister Storage Building in the 200 Area. The initial basis for design, fabrication, installation, and operation of the fuel removal systems was that the basin leak rates which could result from a postulated accident condition would not be excessive relative to reasonable recovery operations. However, an additional potential K Basin water leak path is through the K Basin drain valves. Three twelve-inch drain valves are located in the main basin bays along the north wall. The sumps containing the valves are filled with concrete which covers the drain valve body. Visual observations suggest that only the valve's bonnet and stem are exposed above the basin concrete floor. It was recognized, however, that damage of the drain valve bonnet or stem during a seismic initiating event could provide a potential K Basin water leak path. The objectives of this activity are to: (1) evaluate the risk of damaging the three twelve-inch drain valves located along the north wall of the main basin from a seismic initiating event, and (2) determine the associated potential leak rate from a damaged valve.

  3. Risk assessment of K basin twelve-inch drain valve failure from a postulated seismic initiating event

    Energy Technology Data Exchange (ETDEWEB)

    MORGAN, R.G.

    1999-04-06

    The Spent Nuclear Fuel (SNF) Project will transfer metallic SNF from the Hanford 105 K-East and 105 K-West Basins to safe interim storage in the Canister Storage Building in the 200 Area. The initial basis for design, fabrication, installation, and operation of the fuel removal systems was that the basin leak rates which could result from a postulated accident condition would not be excessive relative to reasonable recovery operations. However, an additional potential K Basin water leak path is through the K Basin drain valves. Three twelve-inch drain valves are located in the main basin bays along the north wall. The sumps containing the valves are filled with concrete which covers the drain valve body. Visual observations suggest that only the valve's bonnet and stem are exposed above the basin concrete floor. It was recognized, however, that damage of the drain valve bonnet or stem during a seismic initiating event could provide a potential K Basin water leak path. The objectives of this activity are to: (1) evaluate the risk of damaging the three twelve-inch drain valves located along the north wall of the main basin from a seismic initiating event, and (2) determine the associated potential leak rate from a damaged valve.

  4. Twelve tips to support the development of clinical reasoning skills using virtual patient cases.

    Science.gov (United States)

    Posel, Nancy; Mcgee, James B; Fleiszer, David M

    2015-01-01

    Clinical reasoning is a critical core competency in medical education. Strategies to support the development of clinical reasoning skills have focused on methodologies used in traditional settings, including lectures, small groups, activities within Simulation Centers and the clinical arena. However, the evolving role and growing utilization of virtual patients (VPs) in undergraduate medical education; as well as an increased emphasis on blended learning, multi-modal models that include VPs in core curricula; suggest a growing requirement for strategies or guidelines that directly focus on VPs. The authors have developed 12 practical tips that can be used in VP cases to support the development of clinical reasoning. These are based on teaching strategies and principles of instructional design and pedagogy, already used to teach and assess clinical reasoning in other settings. Their application within VPs will support educators who author or use VP cases that promote the development of clinical reasoning.

  5. Twelve tips for teaching in a provincially distributed medical education program.

    Science.gov (United States)

    Wong, Roger Y; Chen, Luke; Dhadwal, Gurbir; Fok, Mark C; Harder, Ken; Huynh, Hanh; Lunge, Ryan; Mackenzie, Mark; Mckinney, James; Ovalle, William; Rauniyar, Pooja; Tse, Luke; Villanyi, Diane

    2012-01-01

    As distributed undergraduate and postgraduate medical education becomes more common, the challenges with the teaching and learning process also increase. To collaboratively engage front line teachers in improving teaching in a distributed medical program. We recently conducted a contest on teaching tips in a provincially distributed medical education program and received entries from faculty and resident teachers. Tips that are helpful for teaching around clinical cases at distributed teaching sites include: ask "what if" questions to maximize clinical teaching opportunities, try the 5-min short snapper, multitask to allow direct observation, create dedicated time for feedback, there are really no stupid questions, and work with heterogeneous group of learners. Tips that are helpful for multi-site classroom teaching include: promote teacher-learner connectivity, optimize the long distance working relationship, use the reality television show model to maximize retention and captivate learners, include less teaching content if possible, tell learners what you are teaching and make it relevant and turn on the technology tap to fill the knowledge gap. Overall, the above-mentioned tips offered by front line teachers can be helpful in distributed medical education.

  6. Stress, burnout and doctors' attitudes to work are determined by personality and learning style: a twelve year longitudinal study of UK medical graduates.

    Science.gov (United States)

    McManus, I C; Keeling, A; Paice, E

    2004-08-18

    The study investigated the extent to which approaches to work, workplace climate, stress, burnout and satisfaction with medicine as a career in doctors aged about thirty are predicted by measures of learning style and personality measured five to twelve years earlier when the doctors were applicants to medical school or were medical students. Prospective study of a large cohort of doctors. The participants were first studied when they applied to any of five UK medical schools in 1990. Postal questionnaires were sent to all doctors with a traceable address on the current or a previous Medical Register. The current questionnaire included measures of Approaches to Work, Workplace Climate, stress (General Health Questionnaire), burnout (Maslach Burnout Inventory), and satisfaction with medicine as a career and personality (Big Five). Previous questionnaires had included measures of learning style (Study Process Questionnaire) and personality. Doctors' approaches to work were predicted by study habits and learning styles, both at application to medical school and in the final year. How doctors perceive their workplace climate and workload is predicted both by approaches to work and by measures of stress, burnout and satisfaction with medicine. These characteristics are partially predicted by trait measures of personality taken five years earlier. Stress, burnout and satisfaction also correlate with trait measures of personality taken five years earlier. Differences in approach to work and perceived workplace climate seem mainly to reflect stable, long-term individual differences in doctors themselves, reflected in measures of personality and learning style.

  7. A class III archaeological survey of twelve region wide fencing upgrade locations in Eagle, Grand, Gunnison, Jackson, Moffat, Pitkin, and Routt counties, Colorado

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Colorado Department of Transportation proposes to upgrade existing right-of-way fencing along roadways at twelve separate locations in northwestern Colorado. To...

  8. Biodiversity conservation including uncharismatic species

    DEFF Research Database (Denmark)

    Muñoz, Joaquin

    2007-01-01

    Recent papers mention ideas on the topics of biodiversity conservation strategies and priorities (Redford et al. 2003; Lamoreux et al. 2006; Rodrı´guez et al. 2006), the current status of biodiversity (Loreau et al. 2006), the obligations of conservation biologists regarding management policies...... (Chapron 2006; Schwartz 2006), and the main threats to biodiversity (including invasive species) (Bawa 2006). I suggest, however, that these articles do not really deal with biodiversity. Rather, they all focus on a few obviously charismatic groups (mammals, birds, some plants, fishes, human culture...

  9. FLUXNET2015 Dataset: Batteries included

    Science.gov (United States)

    Pastorello, G.; Papale, D.; Agarwal, D.; Trotta, C.; Chu, H.; Canfora, E.; Torn, M. S.; Baldocchi, D. D.

    2016-12-01

    The synthesis datasets have become one of the signature products of the FLUXNET global network. They are composed from contributions of individual site teams to regional networks, being then compiled into uniform data products - now used in a wide variety of research efforts: from plant-scale microbiology to global-scale climate change. The FLUXNET Marconi Dataset in 2000 was the first in the series, followed by the FLUXNET LaThuile Dataset in 2007, with significant additions of data products and coverage, solidifying the adoption of the datasets as a research tool. The FLUXNET2015 Dataset counts with another round of substantial improvements, including extended quality control processes and checks, use of downscaled reanalysis data for filling long gaps in micrometeorological variables, multiple methods for USTAR threshold estimation and flux partitioning, and uncertainty estimates - all of which accompanied by auxiliary flags. This "batteries included" approach provides a lot of information for someone who wants to explore the data (and the processing methods) in detail. This inevitably leads to a large number of data variables. Although dealing with all these variables might seem overwhelming at first, especially to someone looking at eddy covariance data for the first time, there is method to our madness. In this work we describe the data products and variables that are part of the FLUXNET2015 Dataset, and the rationale behind the organization of the dataset, covering the simplified version (labeled SUBSET), the complete version (labeled FULLSET), and the auxiliary products in the dataset.

  10. Twelve months follow-up after retrograde recanalization of superficial femoral artery chronic total occlusion

    Directory of Open Access Journals (Sweden)

    Joanna Wojtasik-Bakalarz

    2017-03-01

    Full Text Available Introduction : Fifty percent of cases of peripheral artery disease are caused by chronic total occlusion (CTO of the superficial femoral artery (SFA. Ten–fifteen percent of percutaneous SFA recanalization procedures are unsuccessful. In those cases the retrograde technique can increase the success rate of the procedure, but the long-term follow-up of such procedures is still unknown. Aim : To assess the efficacy and clinical outcomes during long-term follow-up after retrograde recanalization of the SFA. Material and methods: We included patients after at least one unsuccessful percutaneous antegrade recanalization of the SFA. Patients were evaluated for the procedural and clinical follow-up of mean time 13.9 months. Results: The study included 17 patients (7 females, 10 males who underwent percutaneous retrograde recanalization of the SFA from June 2011 to June 2015. The mean age of patients was 63 ±7 years. Retrograde puncture of the distal SFA was successful in all cases. A retrograde procedure was performed immediately after antegrade failure in 4 (23.5% patients and after a previously failed attempt in 13 (76.5% patients. The procedure was successful in 15 (88.2% patients, and unsuccessful in 2 (11.8% patients. Periprocedural complications included 1 peripheral distal embolization (successfully treated with aspiration thrombectomy, 1 bleeding event from the puncture site and 7 puncture site hematomas. During follow-up the all-cause mortality rate was 5.8% (1 patient, non-cardiac death. The primary patency rate at 12 months was 88.2% and secondary patency 100%. Conclusions : The retrograde SFA puncture seems to be a safe and successful technique for CTO recanalization and is associated with a low rate of perioperative and long-term follow-up complications.

  11. Twelve tips for getting started using mixed methods in medical education research.

    Science.gov (United States)

    Lavelle, Ellen; Vuk, Jasna; Barber, Carolyn

    2013-04-01

    Mixed methods research, which is gaining popularity in medical education, provides a new and comprehensive approach for addressing teaching, learning, and evaluation issues in the field. The aim of this article is to provide medical education researchers with 12 tips, based on consideration of current literature in the health professions and in educational research, for conducting and disseminating mixed methods research. Engaging in mixed methods research requires consideration of several major components: the mixed methods paradigm, types of problems, mixed method designs, collaboration, and developing or extending theory. Mixed methods is an ideal tool for addressing a full range of problems in medical education to include development of theory and improving practice.

  12. The Extension of The Twelve-Point Sphere Theorem for a Tetrahedron%四面体的十二点二次曲面

    Institute of Scientific and Technical Information of China (English)

    王奇志; 王东生

    2012-01-01

    垂心四面体中四条高的垂足,四个面的重心及从各顶点与四面体的垂心连线的三等分点,共十二个点共球.试图把垂心改为四面体内的任意点,相应地把四条高线改换为过该点与每个顶点连线的共点直线组时,则将把垂心四面体的十二点球有趣地推广为四面体的十二点二次曲面.%The four feet of four altitudes for an orthocenter tetrahedron, the centers of gravity of the four faces, the trisection of the line segments from the orthocenter to four summits, total twelve points lie on same sphere, which is known as twelve-point sphere. If the orthocenter can be changed into any point within a tetrahedron in this paper, and corresponding the four perpendiculars also can be changed into the four lines segment passing through the given point to the summits of the tetrahedron, the twelve-point sphere can be changed into twelve-point quadric surface. Twelve point sphere of an orthocenter tetrahedron can be generalized to the twelve-point quadratic surface of a tetrahedron.

  13. Families classification including multiopposition asteroids

    Science.gov (United States)

    Milani, Andrea; Spoto, Federica; Knežević, Zoran; Novaković, Bojan; Tsirvoulis, Georgios

    2016-01-01

    In this paper we present the results of our new classification of asteroid families, upgraded by using catalog with > 500,000 asteroids. We discuss the outcome of the most recent update of the family list and of their membership. We found enough evidence to perform 9 mergers of the previously independent families. By introducing an improved method of estimation of the expected family growth in the less populous regions (e.g. at high inclination) we were able to reliably decide on rejection of one tiny group as a probable statistical fluke. Thus we reduced our current list to 115 families. We also present newly determined ages for 6 families, including complex 135 and 221, improving also our understanding of the dynamical vs. collisional families relationship. We conclude with some recommendations for the future work and for the family name problem.

  14. Twelve tips for the construction of ethical dilemma case-based assessment.

    Science.gov (United States)

    Tsai, Tsuen-Chiuan

    2017-04-01

    Ethical dilemma case-based examination (ethics Script Concordance Test, eSCT) is a written examination that can be delivered to a large group of examinees for the purpose of measuring high-level thinking. As it accommodates for diverse responses from experts, ethics SCT allows partial credits. The framework of ethics SCT includes a vignette with an ethical dilemma and a leading question, which asks the examinee to "agree" or "disagree", plus the shifts of prior decision by adding new information. In this article, the following tips for constructing this type of examination are provided: use "true" dilemmas, select an appropriate ethical issue, target high-level cognitive tasks, list key components, keep a single central theme, device quality scoring system, be important and plausible, be clear, select quality experts, validate, know the limitation, and be familiar with test materials. The use of eSCT to measure ethical reasoning ability appears to be both viable and desirable.

  15. Twelve tips for applying the science of learning to health professions education.

    Science.gov (United States)

    Gooding, H C; Mann, K; Armstrong, E

    2017-01-01

    Findings from the science of learning have clear implications for those responsible for teaching and curricular design. However, this data has been historically siloed from educators in practice, including those in health professions education. In this article, we aim to bring practical tips from the science of learning to health professions educators. We have chosen to organize the tips into six themes, highlighting strategies for 1) improving the processing of information, 2) promoting effortful learning for greater retention of knowledge over time, 3) applying learned information to new and varied contexts, 4) promoting the development of expertise, 5) harnessing the power of emotion for learning, and 6) teaching and learning in social contexts. We conclude with the importance of attending to metacognition in our learners and ourselves. Health professions education can be strengthened by incorporating these evidence-based techniques.

  16. The OCCASO survey: Presentation and radial velocities of twelve Milky Way Open Clusters

    CERN Document Server

    Casamiquela, L; Jordi, C; Balaguer-Núñez, L; Pancino, E; Hidalgo, S L; Martínez-Vázquez, C E; Murabito, S; del Pino, A; Aparicio, A; Blanco-Cuaresma, S; Gallart, C

    2016-01-01

    Open clusters (OCs) are crucial for studying the formation and evolution of the Galactic disc. However, the lack of a large number of OCs analyzed homogeneously hampers the investigations about chemical patterns and the existence of Galactocentric radial and vertical gradients, or an age-metallicity relation. To overcome this, we have designed the Open Cluster Chemical Abundances from Spanish Observatories survey (OCCASO). We aim to provide homogeneous radial velocities, physical parameters and individual chemical abundances of six or more Red Clump stars for a sample of 25 old and intermediate-age OCs visible from the Northern hemisphere. To do so, we use high resolution spectroscopic facilities (R> 62,000) available at Spanish observatories. We present the motivation, design and current status of the survey, together with the first data release of radial velocities for 77 stars in 12 OCs, which represents about 50% of the survey. We include clusters never studied with high-resolution spectroscopy before (NG...

  17. Twelve thousand laser-AO observations: first results from the Robo-AO large surveys

    Science.gov (United States)

    Law, Nicholas M.; Baranec, Christoph; Riddle, Reed L.

    2014-07-01

    Robo-AO is the first AO system which can feasibly perform surveys of thousands of targets. The system has been operating in a fully robotic mode on the Palomar 1.5m telescope for almost two years. Robo-AO has completed nearly 12,000 high-angular-resolution observations in almost 20 separate science programs including exoplanet characterization, field star binarity, young star binarity and solar system observations. We summarize the Robo-AO surveys and the observations completed to date. We also describe the data-reduction pipeline we developed for Robo-AO—the first fully-automated AO data-reduction, point-spread-function subtraction and companion-search pipeline.

  18. Predictors of the change in bilirubin levels over twelve weeks of treatment with atazanavir

    LENUS (Irish Health Repository)

    Cotter, Aoife G

    2013-05-16

    AbstractObjectiveTo determine the factors associated with change in bilirubin concentration 12 weeks after the initiation of an atazanavir (ATV)-containing antiretroviral regimen.MethodsWe performed a retrospective case note review of all patients prescribed ATV between January 2004 and October 2007 in a cohort of HIV infected subjects. Data collected included baseline demographics, hepatitis B and C serology, current antiretroviral therapy, baseline and week 12 routine bloods. The primary endpoint was the change in bilirubin concentration at 12 weeks after start of ATV. Multvariable linear regression was performed to assess the relationships between the change in bilirubin and variables of interest. Results: Eighty-three ATV-treated patients were included in the analysis of whom 46 (60.5%) were hepatitis C antibody positive. The median (interquartile range) change in bilirubin by week 12 was 16 (4, 22) umol\\/L; only 1 patient developed grade 4 hyperbilirubinaemia at week 12. After controlling for baseline bilirubin levels, HCV seropositivity and baseline ALP were associated with a smaller change in bilirubin over the 12 weeks with a trend towards lower increases in those receiving tenofovir. Sensitivity analyses reported similar associations with methadone use and injection drug use, when these variables replaced HCV sero-positivity in the model. Conclusion: Patients with hepatitis C co-infection experience smaller changes in bilirubin upon exposure to ATV. Although the underlying mechanism for this association remains unclear, these data support the safe use of this drug in this patient setting. Further research into the clinical predictors of ATV-related hyperbilirubinaemia is warranted.

  19. Including Magnetostriction in Micromagnetic Models

    Science.gov (United States)

    Conbhuí, Pádraig Ó.; Williams, Wyn; Fabian, Karl; Nagy, Lesleis

    2016-04-01

    The magnetic anomalies that identify crustal spreading are predominantly recorded by basalts formed at the mid-ocean ridges, whose magnetic signals are dominated by iron-titanium-oxides (Fe3-xTixO4), so called "titanomagnetites", of which the Fe2.4Ti0.6O4 (TM60) phase is the most common. With sufficient quantities of titanium present, these minerals exhibit strong magnetostriction. To date, models of these grains in the pseudo-single domain (PSD) range have failed to accurately account for this effect. In particular, a popular analytic treatment provided by Kittel (1949) for describing the magnetostrictive energy as an effective increase of the anisotropy constant can produce unphysical strains for non-uniform magnetizations. I will present a rigorous approach based on work by Brown (1966) and by Kroner (1958) for including magnetostriction in micromagnetic codes which is suitable for modelling hysteresis loops and finding remanent states in the PSD regime. Preliminary results suggest the more rigorously defined micromagnetic models exhibit higher coercivities and extended single domain ranges when compared to more simplistic approaches.

  20. Birth, growth and progresses through the last twelve years of a regional scale landslide warning system

    Science.gov (United States)

    Fanti, Riccardo; Segoni, Samuele; Rosi, Ascanio; Lagomarsino, Daniela; Catani, Filippo

    2017-04-01

    recordings and landslides occurred) and to use them to define more robust relationships between rainfalls and landslide triggering, with the final aim to increase the forecasting effectiveness of the warning system. The updated rainfall and landslide database were used to periodically perform a quantitative validation and to analyze the errors affecting the system forecasts. The errors characterization was used to implement a continuous process of updating and modification of SIGMA, that included: - Main model upgrades (generalization from a pilot test site to the whole Emilia Romagna region; calibration against well documented landslide events to define specific σ levels for each territorial units; definition of different alert levels according to the number of expected - Ordinary updates (periodically, the new landslide and rainfall data were used to re-calibrate the thresholds, taking into account a more robust sample). - Model tuning (set up of the optimal version of the decisional algorithm, including different definitions of "long" and "short" periods; selection of the optimal reference rain gauge for each Territorial Unit; modification of the boundaries of some territorial - Additional features (definition of a module that takes into account the effect of snow melt and snow accumulation; coupling with a landslide susceptibility model to improve the spatial accuracy of the model). - Various performance tests (including the comparison with alternate versions of SIGMA or with thresholds based on rainfall intensity and duration). This process has led to an evolution of the warning system and to a documented improvement of its forecasting effectiveness. Landslide forecasting at regional scale is a very complex task, but as time passes by and with the systematic gathering of new substantial data and the continuous progresses of research, uncertainties can be progressively reduced and a warning system can be set that increases its performances and reliability with time.

  1. Total Water Vapor Transport Observed in Twelve Atmospheric Rivers over the Northeastern Pacific Ocean Using Dropsondes

    Science.gov (United States)

    Ralph, F. M.; Iacobellis, S.; Neiman, P. J.; Cordeira, J. M.; Spackman, J. R.; Waliser, D. E.; Wick, G. A.; White, A. B.; Fairall, C. W.

    2014-12-01

    Demory et al (2013) recently showed that the global water cycle in climate models, including the magnitude of water vapor transport, is strongly influenced by the model's spatial resolution. The lack of offshore observations is noted as a serious limitation in determining the correct amount of transport. Due to the key role of atmospheric rivers (ARs) in determining the global distribution of water vapor, quantifying transport from ARs is a high priority. This forms a foundation of the CalWater-2 experiment aimed at sampling many ARs during 2014-2018. In February 2014, an "early-start" deployment of the NOAA G-IV research aircraft sampled 10 ARs over the northeast Pacific Ocean. On six of these flights, dropsondes were deployed in a line crossing the AR so as to robustly sample the total water vapor transport (TVT). The TVT is defined here as the sum of the vertically integrated horizontal water vapor transport (IVT) in the AR using a baseline that stretches from its warm southern (or eastern) edge to its cool northern (or western) edge. TVT includes both AR-parallel and AR-perpendicular transport. These data double the overall number of such cross-AR airborne samples suitable for calculating TVT. Analysis of TVT for these six new samples, in combination with the six previous samples from the preceding 16 years (from CalJet, WISPAR, and a Hawaii-based campaign), will be shown. A comparison will be made of the AR width and TVT determined using the well-established integrated water vapor (IWV) threshold of 2 cm, versus an IVT threshold of 250 kg m-1 s-1. Finally, the data from a well sampled case on 13 February 2014 (23 sondes with 75-100 km spacing) will be used to assess the sensitivity of TVT to dropsonde horizontal spacing and vertical resolution. This sensitivity analysis is of practical importance for the upcoming CalWater-2 field campaign where the G-IV will be used to sample many additional AR events, due to the relatively high cost of the dropsondes.

  2. Review of Pasteurella Multocida Infections over a Twelve-Year Period in a Tertiary Care Hospital

    Directory of Open Access Journals (Sweden)

    Athanasia Christidou

    2005-01-01

    Full Text Available The aim of this study was to present the epidemiological, clinical and microbiological data, as well as the management and the outcome of 13 patients with documented Pasteurella multocida infections, diagnosed in the University hospital of Crete, Greece, between 1993 and 2004. Most patients (62% were >70 years of age. Respiratory tract infections were most commonly encountered (61.5%, followed by soft-tissue infections (30.8% and septicemia (7.7 %. Underlying diseases included malignancies, bullous pemphigoid, mitral valve stenosis, coronary disease, chronic obstructive pulmonary disease and intracranial hemorrhage. Antibiotic sensitivity testing showed that all P. multocida isolates were susceptible to beta-lactams, quinolones, chloramphenicol, tetracycline and trimethoprim/sulfamethoxazole. Antibiotics were administered to all 13 patients and a clinical response was observed in 77% of them. The overall mortality rate was 23% (3/13 but only 15.4% (2/13 died from the infection. Although rare, P. multocida infections should be suspected in patients reporting animal exposure, particularly in those with chronic underlying diseases.

  3. Mechanical analysis of twelve toggle suture constructs for stabilization of coxofemoral luxations.

    Science.gov (United States)

    Jha, Shantibhushan; Kowaleski, Michael P

    2012-11-01

    To compare the mechanical performance of 12 commonly used toggle suture constructs (TSCs). In vitro biomechanical study. Toggle suture constructs (n = 136). TSC evaluated included #5 OrthoFiber, double strand of 5 Ethibond sutures (polyethylene terephthalate suture), 80 lb monofilament nylon, or #5 FiberWire, combined with Piermattei toggle (3/32" Steinmann pin), modified Piermattei toggle (0.045" Kirschner wire), and 1/8" Securos toggle rod for a total of 12 test groups. Acute and cyclic testing were performed using a servohydraulic testing machine and load at failure and cycles to failure were determined. In acute testing, modified Piermattei TSCs failed by toggle deformation and Piermattei and Securos TSCs failed by suture breakage at the eyelet. Mean failure load of Piermattei-#5 OrthoFiber TSC (1416 ± 74 N) was significantly greater than that of Piermattei-#5 Ethibond (883 ± 38 N); both were significantly greater than all other TSCs. Only the Piermattei TSC with #5 OrthoFiber, #5 Ethibond, and 80 lb monofilament nylon did not fail during cyclic testing. A combination of the Piermattei toggle and #5 OrthoFiber or #5 Ethibond achieved a higher load at failure than all other groups, and resisted the greatest number of cycles to failure. Long-term mechanical testing of these TSCs are warranted to further define their durability. © Copyright 2012 by The American College of Veterinary Surgeons.

  4. Weight growth of triplet infants from birth to twelve years of age.

    Science.gov (United States)

    Yokoyama, Yoshie; Pitkäniemi, Janne; Kaprio, Jaakko; Silventoinen, Karri

    2012-10-01

    We analyzed the characteristics associated with the growth in weight of Japanese triplets from birth to 12 years of age. The study included 376 mothers and their 1,128 triplet children, who were born between 1978 and 2006. Data were collected through a mailed questionnaire sent to the mothers asking for information recorded in medical records. For these births, data on triplets' weight growth, gestational age, sex, parity, maternal age at delivery, maternal height, and maternal body mass index were obtained from records in the Maternal and Child Health Handbooks and records in the school where children receive health check-ups. The weight deficit of the triplets compared to the general population of Japan remained between 10% and 17% until 12 years of age. Moreover, at 12 years of age, the differences of weight between the general population and triplets were approximately -4.75 kg for boys and -6.00 kg for girls. Very low birth weight had the strongest contribution to body weight until 8 years of age. After 8 years of age, maternal body mass index was a significant factor affecting the weight of triplets until 12 years of age.

  5. Nonperturbative beta function of twelve-flavor SU(3) gauge theory

    CERN Document Server

    Hasenfratz, Anna

    2016-01-01

    We study the discrete beta function of SU(3) gauge theory with Nf=12 massless fermions in the fundamental representation. Using an nHYP-smeared staggered lattice action and an improved gradient flow running coupling $\\tilde g_c^2(L)$ we determine the continuum-extrapolated discrete beta function up to $g_c^2 \\approx 8.2$. We observe an IR fixed point at $g_{\\star}^2 = 7.3\\left(_{-2}^{+3}\\right)$ in the $c = \\sqrt{8t} / L = 0.25$ scheme, and $g_{\\star}^2 = 7.3\\left(_{-3}^{+5}\\right)$ with c=0.3, combining statistical and systematic uncertainties in quadrature. The systematic effects we investigate include the stability of the $(a / L) \\to 0$ extrapolations, the interpolation of $\\tilde g_c^2(L)$ as a function of the bare coupling, the improvement of the gradient flow running coupling, and the discretization of the energy density. We observe that the resulting systematic errors increase dramatically upon combining smaller $c \\lesssim 0.2$ with smaller $L \\leq 12$. At the IR fixed point we measure the leading ir...

  6. Nanosurgery of cells and chromosomes using near-infrared twelve-femtosecond laser pulses.

    Science.gov (United States)

    Uchugonova, Aisada; Lessel, Matthias; Nietzsche, Sander; Zeitz, Christian; Jacobs, Karin; Lemke, Cornelius; König, Karsten

    2012-10-01

    ABSTRACT. Laser-assisted surgery based on multiphoton absorption of near-infrared laser light has great potential for high precision surgery at various depths within the cells and tissues. Clinical applications include refractive surgery (fs-LASIK). The non-contact laser method also supports contamination-free cell nanosurgery. In this paper we describe usage of an ultrashort femtosecond laser scanning microscope for sub-100 nm surgery of human cells and metaphase chromosomes. A mode-locked 85 MHz Ti:Sapphire laser with an M-shaped ultrabroad band spectrum (maxima: 770  nm/830  nm) and an in situ pulse duration at the target ranging from 12 fs up to 3 ps was employed. The effects of laser nanoprocessing in cells and chromosomes have been quantified by atomic force microscopy. These studies demonstrate the potential of extreme ultrashort femtosecond laser pulses at low mean milliwatt powers for sub-100 nm surgery of cells and cellular organelles.

  7. Community Energy Systems and the Law of Public Utilities. Volume Twelve. Georgia

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L

    1981-01-01

    A detailed description of the laws and programs of the State of Georgia governing the regulation of public energy utilities, the siting of energy generating and transmission facilities, the municipal franchising of public energy utilities, and the prescription of rates to be charged by utilities including attendant problems of cost allocations, rate base and operating expense determinations, and rate of return allowances. These laws and programs are analyzed to identify impediments which they may present to the implementation of Integrated Community Energy Systems (ICES). This report is one of fifty-one separate volumes which describe such regulatory programs at the Federal level and in each state as background to the report entitled Community Energy Systems and the Law of Public Utilities - Volume One: An Overview. This report also contains a summary of a strategy described in Volume One - An Overview for overcoming these impediments by working within the existing regulatory framework and by making changes in the regulatory programs to enhance the likelihood of ICES implementation.

  8. Twelve years of the Brazilian External Quality Assessment Program in Immunohematology: benefits of the program.

    Science.gov (United States)

    Melo, Laércio; Pellegrino, Jordão; Bianco, Celso; Castilho, Lilian

    2005-01-01

    The Brazilian External Quality Assessment Program in Immunohematology (BEQAPI) was introduced with the objective of evaluating the quality of diagnosis in immunohematology. From 1992 to 2003, proficiency tests for ABO grouping, Rh (D, C, c, E, e), K phenotyping, direct antiglobulin testing (DAT), antibody screening (AS), and antibody identification (AI) were performed. A total of 41 evaluations were carried out in 223 institutions. Over the period of 12 years, the program included 8,014 ABO typing, 8,000 RhD typing, 5,193 Rh typing (C, c, E, e), 5,101 K phenotyping, 7,939 AS, 4,533 AI, and 7,912 DATs. Erroneous responses were classified as clerical, technical, or undetermined. A substantial proportion of erroneous responses due to clerical errors occurred in ABO typing (76/76 errors), RhD typing (34/58 errors), and Rh phenotyping (50/73 errors). Technical errors occurred predominantly for weak D (91/95 errors), AS (252/301 errors), and AI (321/335 errors). Based on these results, since 1996, participants have received "Questions and Case Studies" in Immunohematology as an incentive for training and education. The results of the present study show an improvement in the performance of participants in the course of the program. We found that a well-organized external proficiency program can contribute to the improvement of quality of testing in Immunohematology.

  9. Twelve years of global observation of formaldehyde in the troposphere using GOME and SCIAMACHY sensors

    Directory of Open Access Journals (Sweden)

    I. De Smedt

    2008-04-01

    Full Text Available This work presents global tropospheric formaldehyde columns retrieved from near-UV radiance measurements performed by the GOME instrument onboard ERS-2 since 1995, and by SCIAMACHY, in operation on ENVISAT since the end of 2002. A special effort has been made to ensure the coherence and quality of the CH2O dataset covering the period 1996–2007. Optimised DOAS settings are proposed in order to reduce the impact of two important sources of error in the derivation of slant columns, namely, the polarisation anomaly affecting the SCIAMACHY spectra around 350 nm, and a major absorption band of the O4 collision complex centred near 360 nm. The air mass factors are determined from scattering weights generated using radiative transfer calculation taking into account the cloud fraction, the cloud height and the ground albedo. Vertical profile shapes of CH2O are provided by the global CTM IMAGES based on an up-to-date representation of emissions, atmospheric transport and photochemistry. A comprehensive error analysis is presented. This includes errors on the slant columns retrieval and errors on the air mass factors which are mainly due to uncertainties in the a priori profile and in the cloud properties. The major features of the retrieved formaldehyde column distribution are discussed and compared with previous CH2O datasets over the major emission regions.

  10. Detection of Potential Transit Signals in the First Twelve Quarters of Kepler Mission Data

    CERN Document Server

    Tenenbaum, Peter; Seader, Shawn; Burke, Christopher J; Christiansen, Jessie L; Rowe, Jason F; Caldwell, Douglas A; Clarke, Bruce D; Li, Jie; Quintana, Elisa V; Smith, Jeffrey C; Thompson, Susan E; Twicken, Joseph D; Borucki, William J; Batalha, Natalie M; Cote, Miles T; Haas, Michael R; Sanderfer, Dwight T; Girouard, Forrest R; Hall, Jennifer R; Ibrahim, Khadeejah; Klaus, Todd C; McCauliff, Sean D; Middour, Christopher K; Sabale, Anima; Uddin, Akm Kamal; Wohler, Bill; Barclay, Thomas; Still, Martin

    2012-01-01

    We present the results of a search for potential transit signals in the first three years of photometry data acquired by the Kepler Mission. The targets of the search include 112,321 targets which were observed over the full interval and an additional 79,992 targets which were observed for a subset of the full interval. From this set of targets we find a total of 11,087 targets which contain at least one signal which meets the Kepler detection criteria: those criteria are periodicity of the signal, an acceptable signal-to-noise ratio, and three tests which reject false positives. Each target containing at least one detected signal is then searched repeatedly for additional signals, which represent multi-planet systems of transiting planets. When targets with multiple detections are considered, a total of 18,406 potential transiting planet signals are found in the Kepler Mission dataset. The detected signals are dominated by events with relatively low signal-to-noise ratios and by events with relatively short ...

  11. Twelve tips for academic role and institutional change in distance learning.

    Science.gov (United States)

    Delgaty, Laura

    2015-01-01

    With the uptake of distance learning (DL), which has been marginal for most clinical academics, teaching contexts, traditional power structures and relationships have changed, leaving lecturers potentially disenfranchised. DL has caused a distinct change in academic roles, but academic and institutional routines have remained unchanged. Information surrounding the changes is confusing and lacks clear guidance. To provide a pragmatic outline of roles, responsibilities, obstacles and solutions for clinical academics involved in DL. A two-year action research project was carried out examining the academic role when developing and delivering a 20 credit post graduate DL module in Clinical Education at Newcastle University. It entailed three strands which were "active" for two weeks at a time in which all activities had to be completed. Sixteen students participated in the module consisting of independent activities, facilitated discussion forums, wikis, required reading, individual and group tasks. Pedagogically, it was based on heavily on Garrison's (2012) and Salmon's (2008) work on constructivism and online communities. Institutions need a clear plan and a change of culture. Roles have emerged including: administrator, manager, team leader knowledge expert, moderator and facilitator. Universities struggle to engage staff with DL due to its unrecognised and (many academics believe) unsustainable workload. These 12 tips provide academics and managers involved in clinical education with clear guidance surrounding strategies that inform practice. New roles have emerged, work habits must be revolutionised and changes in routine must be addressed.

  12. Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection.

    Science.gov (United States)

    Wu, Qi; Zhou, Lina; Sun, Xin; Yan, Zhongfang; Hu, Chunxiu; Wu, Junping; Xu, Long; Li, Xue; Liu, Huiling; Yin, Peiyuan; Li, Kuan; Zhao, Jieyu; Li, Yanli; Wang, Xiaolin; Li, Yu; Zhang, Qiuyang; Xu, Guowang; Chen, Huaiyong

    2017-08-22

    Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term effects of clinical treatments in SARS patients are lacking. Here a total of 25 recovered SARS patients were recruited 12 years after infection. Clinical questionnaire responses and examination findings indicated that the patients had experienced various diseases, including lung susceptibility to infections, tumors, cardiovascular disorders, and abnormal glucose metabolism. As compared to healthy controls, metabolomic analyses identified significant differences in the serum metabolomes of SARS survivors. The most significant metabolic disruptions were the comprehensive increase of phosphatidylinositol and lysophospha tidylinositol levels in recovered SARS patients, which coincided with the effect of methylprednisolone administration investigated further in the steroid treated non-SARS patients with severe pneumonia. These results suggested that high-dose pulses of methylprednisolone might cause long-term systemic damage associated with serum metabolic alterations. The present study provided information for an improved understanding of coronavirus-associated pathologies, which might permit further optimization of clinical treatments.

  13. Twelve Years Since Importance of Cross-Cultural Competency Recognized: Where Are We Now?

    Science.gov (United States)

    Kessler, Remi A.; Coates, Wendy C.; Chanmugam, Arjun

    2017-01-01

    Introduction The objective of this study was to analyze the content and volume of literature that has been written on cultural competency in emergency medicine (EM) since its educational imperative was first described by the Institute of Medicine in 2002. Methods We conducted a comprehensive literature search through the PubMed portal in January 2015 to identify all articles and reviews that addressed cultural competency in EM. Articles were included in the review if cultural competency was described or if its impact on healthcare disparities or curriculum development was described. Two reviewers independently investigated all relevant articles. These articles were then summarized. Results Of the 73 abstracts identified in the initial search, only 10 met criteria for inclusion. A common theme found among these 10 articles is that cultural competency in EM is essential to reducing healthcare disparities and improving patient care. These articles were consistent in their support for cross-cultural educational advancements in the EM curriculum. Conclusion Despite the documented importance of cultural competency education in medicine, there appears to be only 10 articles over the past 12 years regarding its development and implementation in EM. This comprehensive literature review underscores the relative dearth of publications related to cultural competency in EM. The limited number of articles found is striking when compared to the growth of EM research over the same time period and can serve as a stimulus for further research in this significant area of EM education.

  14. Phenolic Composition and Antioxidant and Antiproliferative Activities of the Extracts of Twelve Common Bean (Phaseolus vulgaris L. Endemic Ecotypes of Southern Italy before and after Cooking

    Directory of Open Access Journals (Sweden)

    Maria Neve Ombra

    2016-01-01

    Full Text Available Beans are important dietary components with versatile health benefits. We analysed the extracts of twelve ecotypes of Phaseolus vulgaris in order to determine their phenolic profiles, antioxidant activity, and the in vitro antiproliferative activity. Ultra-performance liquid chromatography with diode array detector (UPLC-DAD admitted us to detect and quantify some known polyphenols, such as gallic acid, chlorogenic acid, epicatechin, myricetin, formononetin, caffeic acid, and kaempferol. The antioxidant activity (AA ranged from 1.568 ± 0.041 to 66.572 ± 3.197 mg necessary to inhibit the activity of the 2,2-diphenyl-1-picrylhydrazyl (DPPH radical by 50% (EC50. The extracts, except those obtained from the nonpigmented samples, were capable of inhibiting the proliferation of the human epithelial colorectal adenocarcinoma (Caco-2 cells, human breast cancer cells MCF-7, and A549 NSCLC cell line. Cultivars differed in composition and concentration of polyphenols including anthocyanins; cooking affected the antioxidant activity only marginally. Qualitative and quantitative differences in phenolic composition between the groups of beans influenced the biological activities; on the other hand, we did not find significant differences on the biological activities within the same variety, before and after cooking.

  15. Transfer of eleven species of the genus Burkholderia to the genus Paraburkholderia and proposal of Caballeronia gen. nov. to accommodate twelve species of the genera Burkholderia and Paraburkholderia.

    Science.gov (United States)

    Dobritsa, Anatoly P; Samadpour, Mansour

    2016-08-01

    It has been proposed to split the genus Burkholderia into two genera according to phylogenetic clustering: (1) a genus retaining this name and consisting mainly of animal and plant pathogens and (2) the genus Paraburkholderia including so-called environmental bacteria. The latter genus name has been validly published recently. During the period between the effective and valid publications of the genus name Paraburkholderia, 16 novel species of the genus Burkholderiawere described, but only two of them can be classified as members of this genus based on the emended genus description. Analysis of traits and phylogenetic positions of the other 11 species shows that they belong to the genus Paraburkholderia, and we propose to transfer them to this genus. The reclassified species names are proposed as Paraburkholderia dipogonis comb. nov., Paraburkholderia ginsengiterrae comb. nov., Paraburkholderia humisilvae comb. nov., Paraburkholderia insulsa comb. nov., Paraburkholderia kirstenboschensis comb. nov., Paraburkholderia metalliresistens comb. nov., Paraburkholderia monticola comb. nov., Paraburkholderia panaciterrae comb. nov., Paraburkholderia rhizosphaerae comb. nov., Paraburkholderia solisilvae comb. nov. and Paraburkholderia susongensis comb. nov. The remaining three species are transferred to the new genus Caballeronia gen. nov. proposed to accommodate twelve species of the genera Burkholderia and Paraburkholderia forming a distinctive clade in phylogenetic trees. The new genus members are Caballeronia choica comb. nov., Caballeronia cordobensis comb. nov., Caballeronia glathei comb. nov., Caballeronia grimmiae comb. nov., Caballeronia humi comb. nov., Caballeronia megalochromosomata comb. nov., Caballeronia jiangsuensis comb. nov., Caballeronia sordidicola comb. nov., Caballeronia telluris comb. nov., Caballeronia terrestris comb. nov., Caballeronia udeis comb. nov., and Caballeronia zhejiangensis comb. nov.

  16. Phenolic Composition and Antioxidant and Antiproliferative Activities of the Extracts of Twelve Common Bean (Phaseolus vulgaris L.) Endemic Ecotypes of Southern Italy before and after Cooking.

    Science.gov (United States)

    Ombra, Maria Neve; d'Acierno, Antonio; Nazzaro, Filomena; Riccardi, Riccardo; Spigno, Patrizia; Zaccardelli, Massimo; Pane, Catello; Maione, Mena; Fratianni, Florinda

    2016-01-01

    Beans are important dietary components with versatile health benefits. We analysed the extracts of twelve ecotypes of Phaseolus vulgaris in order to determine their phenolic profiles, antioxidant activity, and the in vitro antiproliferative activity. Ultra-performance liquid chromatography with diode array detector (UPLC-DAD) admitted us to detect and quantify some known polyphenols, such as gallic acid, chlorogenic acid, epicatechin, myricetin, formononetin, caffeic acid, and kaempferol. The antioxidant activity (AA) ranged from 1.568 ± 0.041 to 66.572 ± 3.197 mg necessary to inhibit the activity of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical by 50% (EC50). The extracts, except those obtained from the nonpigmented samples, were capable of inhibiting the proliferation of the human epithelial colorectal adenocarcinoma (Caco-2) cells, human breast cancer cells MCF-7, and A549 NSCLC cell line. Cultivars differed in composition and concentration of polyphenols including anthocyanins; cooking affected the antioxidant activity only marginally. Qualitative and quantitative differences in phenolic composition between the groups of beans influenced the biological activities; on the other hand, we did not find significant differences on the biological activities within the same variety, before and after cooking.

  17. Challenge of goodness: twelve humanitarian proposals based on the experience of 1991-1995 wars in Croatia and Bosnia and Herzegovina.

    Science.gov (United States)

    Lang, S

    1998-03-01

    Based on the 1991-1995 war experience of peoples of Croatia and Bosnia and Herzegovina, I made twelve proposals regarding the following aspects of health, humanitarian work, and human rights: 1. Broadening of the WHO definition of health by including spiritual well-being (absence of hatred) in it, 2. Inclusion of the term genocide into the Index Medicus (MeSH), 3. Establishment of concepts of prevention of hate, 4. Right to a home, 5. Right of civilians to participate in defense and renewal, 6. Right to deliberation from enslavement and right to find out the fate of missing persons, 7. Global hospital, 8. Monitoring of prisoner-of-war camps, 9. Refugee camps, 10. Providing of care for the abandoned - a new category of people suffering in war, 11. Introduction of the Helping Hand concept, 12. Organization of the Red Cross Forum after the cessation of hostilities. The fundamental objective was to establish the legitimacy of honesty in practice, regulative social mechanisms, and science.

  18. Vital Signs Predict Rapid-Response Team Activation within Twelve Hours of Emergency Department Admission

    Directory of Open Access Journals (Sweden)

    James M. Walston

    2016-05-01

    Full Text Available Introduction: Rapid-response teams (RRTs are interdisciplinary groups created to rapidly assess and treat patients with unexpected clinical deterioration marked by decline in vital signs. Traditionally emergency department (ED disposition is partially based on the patients’ vital signs (VS at the time of hospital admission. We aimed to identify which patients will have RRT activation within 12 hours of admission based on their ED VS, and if their outcomes differed. Methods: We conducted a case-control study of patients presenting from January 2009 to December 2012 to a tertiary ED who subsequently had RRT activations within 12 hours of admission (early RRT activations. The medical records of patients 18 years and older admitted to a non-intensive care unit (ICU setting were reviewed to obtain VS at the time of ED arrival and departure, age, gender and diagnoses. Controls were matched 1:1 on age, gender, and diagnosis. We evaluated VS using cut points (lowest 10%, middle 80% and highest 10% based on the distribution of VS for all patients. Our study adheres to the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology guidelines for reporting observational studies. Results: A total of 948 patients were included (474 cases and 474 controls. Patients who had RRT activations were more likely to be tachycardic (odds ratio [OR] 2.02, 95% CI [1.25-3.27], tachypneic (OR 2.92, 95% CI [1.73-4.92], and had lower oxygen saturations (OR 2.25, 95% CI [1.42-3.56] upon arrival to the ED. Patients who had RRT activations were more likely to be tachycardic at the time of disposition from the ED (OR 2.76, 95% CI [1.65-4.60], more likely to have extremes of systolic blood pressure (BP (OR 1.72, 95% CI [1.08-2.72] for low BP and OR 1.82, 95% CI [1.19-2.80] for high BP, higher respiratory rate (OR 4.15, 95% CI [2.44-7.07] and lower oxygen saturation (OR 2.29, 95% CI [1.43-3.67]. Early RRT activation was associated with increased healthcare

  19. Geothermal elastomeric materials. Twelve-months progress report, October 1, 1976--September 30, 1977

    Energy Technology Data Exchange (ETDEWEB)

    Hirasuna, A.R.; Bilyeu, G.D.; Davis, D.L.; Stephens, C.A.; Veal, G.R.

    1977-12-01

    Progress is reported on efforts to develop elastomers for packer seal element applications which will survive downhole geothermal well chemistry at 260/sup 0/C (500/sup 0/F) for 24 hours. To achieve this development, a three level elastomer testing and evaluation program was established. The first level Screening Tests is a broad screening of potential candidates and with the end objective to filter out the more promising candidates for more expensive subsequent testing. The battery of tests include standard ASTM tests and a special test developed to test extrusion resistance using specimens all made from sheet stock. The second level or Simulation Tests provide a laboratory equivalent of downhole conditions using synthetic geothermal fluid. Full scale packer seals are tested under simulated operational conditions by a test fixture. The third level or In-Situ Tests which are currently in the planning, provide for testing the most favored materials in-situ in the geothermal well. A test module provides for testing of the specimen without interfacing with the well casing. A test module freely hanging on a wireline has much lower probability of causing a problem, such as becoming lodged in the well, as compared to an operational casing packer. This maximizes the number of wells (hence geothermal environments) where access can be gained and In-Situ Testing performed. During this period commercially available polymers were investigated. Most of the work centered around formulating peroxide cured Vitons and some on EPDMs, butyls, and resin cured Vitons. Of the formulations tested to date the EPDMs appear most promising and the peroxide cured Vitons next most promising. However, data is too sparse to make any firm conclusions at this time. Minor tasks were performed evaluating current commercially available elastomers used in oil tools and conceptualization of casing packer for the geothermal application.

  20. Retention and Effectiveness of Dental Sealant After Twelve Months in Iranian Children

    Directory of Open Access Journals (Sweden)

    Rafatjou

    2013-12-01

    Full Text Available Background Pit-and-fissure sealants are safe and effective ways to prevent dental caries and are considered as a part of an overall caries-preventive strategy. Dental caries are a public health problem and the most common intraoral disease affecting mankind. It is an infectious transmissible disease, with the child patient being at the highest risk. Objectives The purpose of this study was to evaluate the retention rates and effectiveness of occlusal sealants in children in Hamadan, Iran. Materials and Methods A total of 118 sealed first permanent molar teeth in 52 students (mean age, 8 years;male, 48% were evaluated for fissure sealant retention and occlusal caries status. All teeth were examined 12 months after application of sealants. Data were collected and evaluated by survival analyses methods for age at placement, patient sex, decayed/missing/filled teeth (DMFT index, fluoride history, toothbrush, tooth position in arch, and refer to dentistry. Results The overall success rate with pit-and-fissure sealant was 68.6%; in addition, 38.9% of the seals were completely retained, 38.9% partially lost, and 10.2% completely lost. There were no signs of carious lesions in 69.6% of the teeth. The factors associated with an increased risk of failure included female sex (P = 0.001 and no history of fluoride use (P < 0.01. There were no significant association between the results and patient age, tooth position in the arch, DMFT index, toothbrush, and refer to dentistry. Conclusions Although pit-and-fissure sealants are effective methods for preventing tooth caries, the low success rate of fissure sealants in current study indicated that dental sealant need to be implemented more carefully and follow-up programs are advisable.

  1. Twelve reasons to refuse the nuclear in the MDP; Douze raisons pour refuser le nucleaire dans le MDP

    Energy Technology Data Exchange (ETDEWEB)

    Bonduelle, A

    2000-07-01

    The author presents twelve reasons which show that the nuclear energy has not a place in the MDP Mechanism of Clean Development: a main loophole for the developed countries, the doubtful ''additionality'' of the nuclear, the treaty ratification is more difficult with the nuclear, the domestic energy conservation is more efficient in Europe than the nuclear development, the nuclear white elephants facing the South debts, the technology transfers are doubtful, the developing countries and the sustainable development policies are evicted from the MDP, some options are more powerful in the South, the reactors and transport networks size are unsuited, the absence of democratic control, the nuclear proliferation, the nuclear safety and the wastes. (A.L.B.)

  2. Twelve positions in a β-lactamase that can expand its substrate spectrum with a single amino acid substitution.

    Directory of Open Access Journals (Sweden)

    Hyojeong Yi

    Full Text Available The continuous evolution of β-lactamases resulting in bacterial resistance to β-lactam antibiotics is a major concern in public health, and yet the underlying molecular basis or the pattern of such evolution is largely unknown. We investigated the mechanics of the substrate fspectrum expansion of the class A β-lactamase using PenA of Burkholderia thailandensis as a model. By analyzing 516 mutated enzymes that acquired the ceftazidime-hydrolyzing activity, we found twelve positions with single amino acid substitutions (altogether twenty-nine different substitutions, co-localized at the active-site pocket area. The ceftazidime MIC (minimum inhibitory concentration levels and the relative frequency in the occurrence of substitutions did not correlate well with each other, and the latter appeared be largely influenced by the intrinsic mutational biases present in bacteria. Simulation studies suggested that all substitutions caused a congruent effect, expanding the space in a conserved structure called the omega loop, which in turn increased flexibility at the active site. A second phase of selection, in which the mutants were placed under increased antibiotic pressure, did not result in a second mutation in the coding region, but a mutation that increased gene expression arose in the promoter. This result suggests that the twelve amino acid positions and their specific substitutions in PenA may represent a comprehensive repertoire of the enzyme's adaptability to a new substrate. These mapped substitutions represent a comprehensive set of general mechanical paths to substrate spectrum expansion in class A β-lactamases that all share a functional evolutionary mechanism using common conserved residues.

  3. Twelve years of clinical practice guideline development, dissemination and evaluation in Canada (1994 to 2005

    Directory of Open Access Journals (Sweden)

    Bai Nan

    2009-08-01

    Full Text Available Abstract Background Despite the growing availability of clinical practice guidelines since the early 1990's, little is known about how guideline development and dissemination may have changed over time in Canada. This study compares Canadian guideline development, dissemination, and evaluation in two six year periods from 1994–1999 and 2000–2005. Methods Survey of guideline developers who submitted their clinical practice guidelines to the Canadian Medical Association Infobase (a Canadian guideline repository between 1994 and 2005. Survey items included information about the developers, aspects of guideline development, and dissemination and evaluation activities. Results Surveys were sent to the developers of 2341 guidelines in the CMA Infobase over the 12 year period, 1664 surveys were returned (response rate 71%. Of these, 730 unique guidelines were released from 1994–1999, and 630 were released from 2000–2005. Compared to the earlier period, more recent guidelines were being produced in English only. There has been little change in the type of organizations developing guidelines with most developed by provincial and national organizations. In the recent period, developers were more likely to report using computerized search strategies (94% versus 88%, publishing the search strategy (42% versus 34%, reaching consensus using open discussion (95% versus 78%, and evaluating effectiveness of the dissemination strategies (12% versus 6% and the impact of the CPGs on health outcomes (24% versus 5%. Recent guidelines were less likely to be based on literature reviews (94% versus 99.6% and were disseminated using fewer strategies (mean 4.78 versus 4.12. Conclusion Given that guideline development processes have improved in some areas over the past 12 years yet not in others, ongoing monitoring of guideline quality is required. Guidelines produced more recently in Canada are less likely to be based on a review of the evidence and only about

  4. Twelve thousand years of dust: the Holocene global dust cycle constrained by natural archives

    Directory of Open Access Journals (Sweden)

    S. Albani

    2014-11-01

    Full Text Available Mineral dust plays an important role in the climate system by interacting with radiation, clouds, and biogeochemical cycles. In addition, natural archives show that the dust cycle experienced variability in the past in response to global and local climate change. The compilation of the DIRTMAP paleodust datasets in the last two decades provided a target for paleoclimate models that include the dust cycle, following a time slice approach. We propose an innovative framework to organize a paleodust dataset that moves on from the positive experience of DIRTMAP and takes into account new scientific challenges, by providing a concise and accessible dataset of temporally resolved records of dust mass accumulation rates and particle grain-size distributions. We consider data from ice cores, marine sediments, loess/paleosol sequences, lake sediments, and peat bogs for this compilation, with a temporal focus on the Holocene period. This global compilation allows investigation of the potential, uncertainties and confidence level of dust mass accumulation rates reconstructions, and highlights the importance of dust particle size information for accurate and quantitative reconstructions of the dust cycle. After applying criteria that help to establish that the data considered represent changes in dust deposition, 43 paleodust records have been identified, with the highest density of dust deposition data occurring in the North Atlantic region. Although the temporal evolution of dust in the North Atlantic appears consistent across several cores and suggest that minimum dust fluxes are likely observed during the Early to mid-Holocene period (6000–8000 years ago, the magnitude of dust fluxes in these observations is not fully consistent, suggesting that more work needs to be done to synthesize datasets for the Holocene. Based on the data compilation, we used the Community Earth System Model to estimate the mass balance and variability of the global dust cycle

  5. 5S rDNA characterization in twelve Sciaenidae fish species (Teleostei, Perciformes: depicting gene diversity and molecular markers

    Directory of Open Access Journals (Sweden)

    Fernanda A. Alves-Costa

    2008-01-01

    Full Text Available In order to extend the genetic data on the Sciaenidae fish family, the present study had the purpose to characterize PCR-generated 5S rDNA repeats of twelve species of this group through PAGE (Polyacrylamide Gel Electrophoresis analysis. The results showed the occurrence of at least two different 5S rDNA size classes in all the species. Moreover, 5S rDNA repeats of one of the studied species - Isopisthus parvipinnis - were cloned and subjected to nucleotide sequencing and Southern blot membrane hybridization analyses, which permitted to confirm the existence of two major 5S rDNA classes. Phylogenetic analysis based on the nucleotide sequences of different 5S rDNA repeats of I. parvipinnis lead to their separation into two major clusters. These results may reflect the high dynamism that rules the evolution rate of 5S rDNA repeats. The obtained data suggest that 5S rDNA can be useful in genetic analyses to identify species-specific markers and determine relationships among species of the Sciaenidae group.

  6. Uptake of radionuclide thorium by twelve native plants grown in uranium mill tailings soils from south part of China

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Xun, E-mail: m13836295186@163.com

    2016-08-01

    Highlights: • Screen dominant plants grown in uranium mill tailings soils. • Quantify the content of {sup 232}Th of soil samples from uranium mill tailings. • Quantify the transfer factor, bioconcentration factor and phytoremediation factor. • Screen out the plant species capable of remediating radionuclide contaminated soils. • Guide the reuse of study area in future. - Abstract: The concentrations of thorium ({sup 232}Th) in soil from a uranium mill tailings repository in South China were analyzed. The results showed that all the soil samples were acidic and the concentrations of {sup 232}Th in all the soil samples were more than the natural radionuclide content in soil of China. Through the field investigation, twelve kinds of dominant plants were discovered. The total quantity of {sup 232}Th in the whole plant is highest in rice flat sedge. We also found that Miscanthus floridulus has the greatest transfer factor (TF) for {sup 232}Th, rice flat sedge has the greatest bioconcentration factor (BF) for {sup 232}Th. At the mean time, M. floridulus has the greatest phytoremediation factor (PF) for {sup 232}Th. On the basis of the above conclusions and the definition for hyperaccumulator, rice flat sedge and M. floridulus could be the candidates of phytoremediation for radionuclide {sup 232}Th in the soil.

  7. Videofluoroscopy of the oral phase of swallowing in eight to twelve years old children with dental malocclusion.

    Science.gov (United States)

    Junqueira, Patricia; Costa, Milton Melciades

    2013-11-01

    The objective of this study was to describe the oral phase of swallowing in individuals with dental malocclusion and to generate data that would contribute to the rehabilitation of those patients. The study was based on the evaluation of the swallowing system through videofluoroscopy on thirty-four children of both genders, aged eight to twelve years old who present with Angle Class II and III dental malocclusions. Thirteen children of similar age and gender presenting normal dental occlusion formed the control group. The results indicated that the oral phase of swallowing is different between individuals with normal occlusion and malocclusion. Dental occlusion types Angle Class II and III did not present a swallowing pattern, independently of the amount of liquid ingested. The swallowing appeared effective in the oral phase of individuals with dental malocclusion, even though adaptations were identified. The outcome, in the absence of a single pattern and the efficiency of the adapted swallowing demonstrates, first a need for additional research investigating orofacial myofunctional treatment for patients with malocclusion and second how such analyses should focus on contributing positively to the rehabilitation of these patients.

  8. Advanced LIGO Two-Stage Twelve-Axis Vibration Isolation and Positioning Platform. Part 2: Experimental Investigation and Tests Results

    CERN Document Server

    Matichard, Fabrice; Mason, Kenneth; Mittleman, Richard; Abbott, Benjamin; Abbott, Samuel; Allwine, Eric; Barnum, Samuel; Birch, Jeremy; Biscans, Sebastien; Clark, Daniel; Coyne, Dennis; DeBra, Dan; DeRosa, Ryan; Foley, Stephany; Fritschel, Peter; Giaime, Joseph A; Gray, Corey; Grabeel, Gregory; Hanson, Joe; Hillard, Michael; Kissel, Jeffrey; Kucharczyk, Christopher; Roux, Adrien Le; Lhuillier, Vincent; Macinnis, Myron; OReilly, Brian; Ottaway, David; Paris, Hugo; Puma, Michael; Radkins, Hugh; Ramet, Celine; Robinson, Mitchell; Ruet, Laurent; Sareen, Pradeep; Shoemaker, Daivid; Stein, Andy; Thomas, Jeremy; Vargas, Michael; Warner, Jimmy

    2014-01-01

    This paper presents the results of the past seven years of experimental investigation and testing done on the two-stage twelve-axis vibration isolation platform for Advanced LIGO gravity waves observatories. This five-ton two-and-half-meter wide system supports more than a 1000 kg of very sensitive equipment. It provides positioning capability and seismic isolation in all directions of translation and rotation. To meet the very stringent requirements of Advanced LIGO, the system must provide more than three orders of magnitude of isolation over a very large bandwidth. It must bring the motion below 10^(-11) m/(Hz)^0.5 at 1 Hz and 10^(-12) m/(Hz)^0.5 at 10 Hz. A prototype of this system has been built in 2006. It has been extensively tested and analyzed during the following two years. This paper shows how the experimental results obtained with the prototype were used to engineer the final design. It highlights how the engineering solutions implemented not only improved the isolation performance but also greatl...

  9. Twelve-month safety and efficacy of inhaled fluticasone propionate in children aged 1 to 3 years with recurrent wheezing

    DEFF Research Database (Denmark)

    Bisgaard, Hans; Allen, David; Milanowski, Janusz;

    2004-01-01

    : There was no significant difference in mean adjusted growth rates between the 2 groups: 84.0 mm/year in the FP group versus 86.4 mm/year in the SCG group (difference FP-SCG: -2.4 mm/year; 95% confidence interval: -6.6 to 1.8). Growth comparisons were independent of age, gender, previous use of steroid, or whether measured......, exacerbations, and requirements for oral steroid treatment and more symptom-free days and days without use of rescue treatment. CONCLUSIONS: Twelve months of treatment with inhaled FP (100 microg twice daily) in preschool children aged 1 to 3 years with recurrent wheeze has no effect on growth and no other......OBJECTIVE: Our aim was to compare the 12-month safety and efficacy of fluticasone propionate (FP) and sodium cromoglycate (SCG) in children aged 1 to 3 years with mild to moderate recurrent wheeze. METHODS: The study was a randomized, parallel-group, open-label multicenter study of 625 children...

  10. A First Assessment of Mycobacterium tuberculosis Genetic Diversity and Drug-Resistance Patterns in Twelve Caribbean Territories

    Directory of Open Access Journals (Sweden)

    Julie Millet

    2014-01-01

    Full Text Available With the exception of some French-speaking islands, data on tuberculosis (TB in the Caribbean are scarce. In this study, we report a first assessment of genetic diversity of a convenience sample of Mycobacterium tuberculosis strains received from twelve Caribbean territories by spoligotyping and describe their drug-resistance patterns. Of the 480 isolates, 40 (8.3% isolates showed resistance to at least one anti-TB drug. The proportion of drug-resistant strains was significantly higher in The Bahamas (21.4%; P=0.02, and Guyana (27.5%; P<0.0001, while it was significantly lower in Jamaica (2.4%; P=0.03 than in other countries of the present study. Regarding genetic diversity, 104 distinct spoligotype patterns were observed: 49 corresponded to clustered strains (2 to 93 strains per cluster, while 55 remained unclustered among which 16 patterns were not reported previously. Combining the study results with regional data retrieved from the international SITVIT2 database underlined a connection between frequency of certain M. tuberculosis phylogenetic lineages and the language spoken, suggesting historical (colonial and ongoing links (trade, tourism, and migratory flows with European countries with which they shared a common past.

  11. Chemical Abundances in Twelve Red Giants of the Large Magellanic Cloud from High-Resolution Infrared Spectroscopy

    CERN Document Server

    Smith, V V; Cunha, K; Plez, B; Lambert, D L; Pilachowski, C A; Barbuy, B; Melendez, J; Balachandran, S C; Bessell, M S; Geisler, D; Hesser, J E; Winge, C

    2002-01-01

    High-resolution infrared spectra (R=50,000) have been obtained for twelve red-giant members of the LMC with the Gemini South 8.3-meter telescope plus Phoenix spectrometer. Quantitative chemical abundances of carbon-12, carbon-13, nitrogen-14, and oxygen-16 were derived from molecular lines of CO, CN, and OH, while sodium, scandium, titanium, and iron abundances were derived from neutral atomic lines. The LMC giants have masses from about 1 to 4 solar masses and span a metallicity range from [Fe/H]= -1.1 to -0.3. The program red giants all show evidence of first dredge-up mixing, with low 12C/13C ratios, and low 12C correlated with high 14N abundances. Comparisons of the oxygen-to-iron ratios in the LMC and the Galaxy indicate that the trend of [O/Fe] versus [Fe/H] in the LMC falls about 0.2 dex below the Galactic trend. Such an offset can be modeled as due to an overall lower rate of supernovae per unit mass in the LMC relative to the Galaxy, as well as a slightly lower ratio of supernovae of type II to super...

  12. HLA compatibility assessment and management of highly sensitized patients under the new kidney allocation system (KAS): A 2016 status report from twelve HLA laboratories across the U.S.

    Science.gov (United States)

    Kamoun, M; Phelan, D; Noreen, H; Marcus, N; Klingman, L; Gebel, H M

    2017-01-01

    Twelve HLA laboratories were surveyed to assess the methods and operational issues involved to define highly sensitized patients and to assess HLA compatibility under the new kidney allocation system (KAS) in the U.S. All laboratories used single antigen bead assays both pre- and post-KAS to define both broad and allele-specific HLA antibodies. The methods and threshold used to list HLA unacceptable antigens in UNet for virtual crossmatch (vXM) and the criteria used for determining HLA compatibility varied among laboratories. Laboratories reported several limitations of the current assays including the accuracy of quantifiable antibody fluorescence values, inadequate coverage of common alleles on the bead panels, and challenges in calibrating the vXM. The new KAS has resulted in a significant surge of deceased donor organ offers requiring vXM evaluation under tight time constraints. In the post-KAS period, eight of twelve laboratories (67%) indicated that their center did not proceed to transplant based on vXM without a prospective lymphocyte crossmatch. In conclusion, HLA laboratories play a critical role in deceased donor allocation for highly sensitized patients under the new KAS. Significant opportunities exist to improve the methods used in the assessment of HLA compatibility to safely transplant highly sensitized patients.

  13. 基于ADAMS的12自由度动力总成悬置系统怠速隔振分析%Idle Vibration Isolation Analysis of Twelve Degrees of Freedom Power-train Mounting System Based on ADAMS

    Institute of Scientific and Technical Information of China (English)

    张健; 杨啟梁; 胡溧; 杨胜; 杨培刚

    2013-01-01

    This paper takes a light duty bus as study object to establish ADAMS dynamic model which includes twelve degrees of freedom powertrain mounting system of two rigid bodies of powertrain and body, and presents a method to determine engine idle excitation which combines test and theoretical calculation. The paper uses this model to carry out simulation calculation and analysis of idle vibration isolation performance of powertrain mounting system. The comparison between simulation results and test results shows that these two results agree well, indicating that the established twelve degrees of freedom ADAMS model and the engine excitation are correct.%以某轻型客车为研究对象,建立了包括动力总成和车身两个刚体的12自由度动力总成悬置系统的ADAMS动力学模型,提出了一种试验与理论计算相结合确定发动机怠速激励的方法.采用该模型对动力总成悬置系统怠速隔振性能进行了仿真计算与分析.仿真结果与试验结果对比表明二者吻合较好,说明所建立的12自由度ADAMS模型和确定的发动机激励是准确的.

  14. 12 Daghem: Beskrivning av uppfostringsklimat och sociala relationer (Twelve Day Care Centers: A Multisite Comparison of Day-Care Climate and Social Relations).

    Science.gov (United States)

    Ekholm, Bodil; Hedin, Anna

    Twelve day care centers in a Swedish commune were systematically observed. Centers were selected on the basis of responses to a questionnaire on attitudes about upbringing which was answered by all the personnel at the 104 day care centers in the commune. Four of the selected centers represented a so-called "present-focused" upbringing…

  15. Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on 'black bone disease' in Italy.

    Science.gov (United States)

    Nemethova, Martina; Radvanszky, Jan; Kadasi, Ludevit; Ascher, David B; Pires, Douglas E V; Blundell, Tom L; Porfirio, Berardino; Mannoni, Alessandro; Santucci, Annalisa; Milucci, Lia; Sestini, Silvia; Biolcati, Gianfranco; Sorge, Fiammetta; Aurizi, Caterina; Aquaron, Robert; Alsbou, Mohammed; Lourenço, Charles Marques; Ramadevi, Kanakasabapathi; Ranganath, Lakshminarayan R; Gallagher, James A; van Kan, Christa; Hall, Anthony K; Olsson, Birgitta; Sireau, Nicolas; Ayoob, Hana; Timmis, Oliver G; Sang, Kim-Hanh Le Quan; Genovese, Federica; Imrich, Richard; Rovensky, Jozef; Srinivasaraghavan, Rangan; Bharadwaj, Shruthi K; Spiegel, Ronen; Zatkova, Andrea

    2016-01-01

    Alkaptonuria (AKU) is an autosomal recessive disorder caused by mutations in homogentisate-1,2-dioxygenase (HGD) gene leading to the deficiency of HGD enzyme activity. The DevelopAKUre project is underway to test nitisinone as a specific treatment to counteract this derangement of the phenylalanine-tyrosine catabolic pathway. We analysed DNA of 40 AKU patients enrolled for SONIA1, the first study in DevelopAKUre, and of 59 other AKU patients sent to our laboratory for molecular diagnostics. We identified 12 novel DNA variants: one was identified in patients from Brazil (c.557T>A), Slovakia (c.500C>T) and France (c.440T>C), three in patients from India (c.469+6T>C, c.650-85A>G, c.158G>A), and six in patients from Italy (c.742A>G, c.614G>A, c.1057A>C, c.752G>A, c.119A>C, c.926G>T). Thus, the total number of potential AKU-causing variants found in 380 patients reported in the HGD mutation database is now 129. Using mCSM and DUET, computational approaches based on the protein 3D structure, the novel missense variants are predicted to affect the activity of the enzyme by three mechanisms: decrease of stability of individual protomers, disruption of protomer-protomer interactions or modification of residues in the region of the active site. We also present an overview of AKU in Italy, where so far about 60 AKU cases are known and DNA analysis has been reported for 34 of them. In this rather small group, 26 different HGD variants affecting function were described, indicating rather high heterogeneity. Twelve of these variants seem to be specific for Italy.

  16. Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on ‘black bone disease' in Italy

    Science.gov (United States)

    Nemethova, Martina; Radvanszky, Jan; Kadasi, Ludevit; Ascher, David B; Pires, Douglas E V; Blundell, Tom L; Porfirio, Berardino; Mannoni, Alessandro; Santucci, Annalisa; Milucci, Lia; Sestini, Silvia; Biolcati, Gianfranco; Sorge, Fiammetta; Aurizi, Caterina; Aquaron, Robert; Alsbou, Mohammed; Marques Lourenço, Charles; Ramadevi, Kanakasabapathi; Ranganath, Lakshminarayan R; Gallagher, James A; van Kan, Christa; Hall, Anthony K; Olsson, Birgitta; Sireau, Nicolas; Ayoob, Hana; Timmis, Oliver G; Le Quan Sang, Kim-Hanh; Genovese, Federica; Imrich, Richard; Rovensky, Jozef; Srinivasaraghavan, Rangan; Bharadwaj, Shruthi K; Spiegel, Ronen; Zatkova, Andrea

    2016-01-01

    Alkaptonuria (AKU) is an autosomal recessive disorder caused by mutations in homogentisate-1,2-dioxygenase (HGD) gene leading to the deficiency of HGD enzyme activity. The DevelopAKUre project is underway to test nitisinone as a specific treatment to counteract this derangement of the phenylalanine-tyrosine catabolic pathway. We analysed DNA of 40 AKU patients enrolled for SONIA1, the first study in DevelopAKUre, and of 59 other AKU patients sent to our laboratory for molecular diagnostics. We identified 12 novel DNA variants: one was identified in patients from Brazil (c.557T>A), Slovakia (c.500C>T) and France (c.440T>C), three in patients from India (c.469+6T>C, c.650–85A>G, c.158G>A), and six in patients from Italy (c.742A>G, c.614G>A, c.1057A>C, c.752G>A, c.119A>C, c.926G>T). Thus, the total number of potential AKU-causing variants found in 380 patients reported in the HGD mutation database is now 129. Using mCSM and DUET, computational approaches based on the protein 3D structure, the novel missense variants are predicted to affect the activity of the enzyme by three mechanisms: decrease of stability of individual protomers, disruption of protomer-protomer interactions or modification of residues in the region of the active site. We also present an overview of AKU in Italy, where so far about 60 AKU cases are known and DNA analysis has been reported for 34 of them. In this rather small group, 26 different HGD variants affecting function were described, indicating rather high heterogeneity. Twelve of these variants seem to be specific for Italy. PMID:25804398

  17. Dual-resolution Raman spectroscopy for measurements of temperature and twelve species in hydrocarbon–air flames

    Energy Technology Data Exchange (ETDEWEB)

    Magnotti, Gaetano; Barlow, Robert S.

    2016-07-12

    This study introduces dual-resolution Raman spectroscopy as a novel diagnostics approach for measurements of temperature and species in flames where multiple hydrocarbons are present. Simultaneous measurement of multiple hydrocarbons is challenging because their vibrational Raman spectra in the C–H stretch region are closely overlapped and are not well known over the range of temperature encountered in flames. Overlap between the hydrocarbon spectra is mitigated by adding a second spectrometer, with a higher dispersion grating, to collect the Raman spectra in the C–H stretch region. A dual-resolution Raman spectroscopy instrument has been developed and optimized for measurements of major species (N2, O2, H2O, CO2, CO, H2, DME) and major combustion intermediates (CH4, CH2O, C2H2, C2H4 and C2H6) in DME–air flames. The temperature dependences of the hydrocarbon Raman spectra over fixed spectral regions have been determined through a series of measurements in laminar Bunsen-burner flames, and have been used to extend a library of previously acquired Raman spectra up to flame temperature. The paper presents the first Raman measurements of up to twelve species in hydrocarbon flames, and the first quantitative Raman measurements of formaldehyde in flames. Lastly, the accuracy and precision of the instrument are determined from measurements in laminar flames and the applicability of the instrument to turbulent DME–air flames is discussed.

  18. [Effect of broken black tea on the formation of dental enamel and the contents of twelve kinds of chemical elements].

    Science.gov (United States)

    Cao, Jin; Yao, Zhigang; Yi, Juan; Zhao, Yan; Zhong, Jie; Yuan, Huabing

    2009-11-01

    The aim of this study was to investigate the effect of broken black tea with slightly hyper-normal fluoride content which was near the level of people tea-drinking habits on enamel morphological structure and its content of chemical elements. Thirty six rats were divided randomly into 3 groups: one was control group and another two groups fed with broken black tea infusion with F- content of 8.2 mg/l and 16.4 mg/l, respectively. After 360 days, collected 144 teeth, observed their morphological structure by electron micrograph, Scanning electron micrographs (SEM) and also analyzed concentrations of several chemical elements in tooth by x-ray fluorescence spectrometry (XRF). Chronic dental fluorosis in rats was induced by treatment with broken black tea with slightly hyper-normal fluoride content. Hyper-calcification and hypo-calcification appeared in enamel of those teeth from both broken black tea treated groups in dose-dependent manner. Twelve kinds of chemical elements, such as Ca, Mg, P, Al, Cl were examined. The contents of Ca, P, Mg were reduced and that of Al and Cl were increased significantly. Compared with control group, the levels of Si, S, Fe were lower in those teeth from treated group (broken black tea with the F- content of 8.2 mg/l), while higher in those teeth from treated group (broken black tea with the F- content of 16.4 mg/l). Long-term drinking broken black tea with hyper-normal fluoride content could cause chronic dental fluorosis, and its injury in enamel was related with Hyper-calcification and hypo-calcification mainly. Those changes of several chemical elements level in enamel, such as Ca, P, Al, Cl, were suggested that these chemical elements have influences on the development and mineralization of enamel.

  19. Monitoring field susceptibility to imidacloprid in the cat flea: a world-first initiative twelve years on.

    Science.gov (United States)

    Kopp, Steven; Blagburn, Byron; Coleman, Glen; Davis, Wendell; Denholm, Ian; Field, Chris; Hostetler, Joe; Mencke, Norbert; Rees, Robert; Rust, Michael; Schroeder, Iris; Tetzner, Kathrin; Williamson, Martin

    2013-08-01

    In 2001, an international surveillance initiative was established, utilising a validated larval development inhibition assay to track the susceptibility of cat flea isolates to imidacloprid. In 2009, an Australian node was incorporated into the programme, joining laboratories in the United States and Europe. Field isolates of Ctenocephalides felis eggs were submitted to participating laboratories and, where egg quantity and quality was sufficient, were placed in the imidacloprid discriminating dose bioassay for evaluation. Between 2002 and 2012, a total of 2,307 cat flea isolates were received across all sites; 1,685 submissions (73 %) were suitable for placement into the bioassay. In the Northern Hemisphere, isolate submission rate was influenced by season, with highest numbers submitted between June and October. In Australia, pets with flea infestations could be sourced year-round, and submission rate was largely influenced by programme factors and not climate. A total of 1,367 valid assays were performed between 2002 and 2012 (assay validity data was not recorded in 2001); adult flea emergence 5 % or greater at 3 ppm imidacloprid was observed in 38 of these assays (2.8 %). For these isolates that reached the threshold for further investigation, re-conduct of the assay using either a repeat challenge dose of 3 ppm of imidacloprid or a dose response probit analysis confirmed their susceptibility to imidacloprid. From 2009 to 2012, the Australian node performed valid assays on 97 field isolates from a total of 136 submissions, with no adult emergence observed at the 3-ppm imidacloprid discriminating dose. In addition to reviewing the data generated by this twelve-year initiative, this paper discusses lessons learned from the coordination and evolution of a complex project across geographically dispersed laboratories on three continents.

  20. Functional roles and substrate specificities of twelve cytochromes P450 belonging to CYP52 family in n-alkane assimilating yeast Yarrowia lipolytica.

    Science.gov (United States)

    Iwama, Ryo; Kobayashi, Satoshi; Ishimaru, Chiaki; Ohta, Akinori; Horiuchi, Hiroyuki; Fukuda, Ryouichi

    2016-06-01

    Yarrowia lipolytica possesses twelve ALK genes, which encode cytochromes P450 in the CYP52 family. In this study, using a Y. lipolytica strain from which all twelve ALK genes had been deleted, strains individually expressing each of the ALK genes were constructed and their roles and substrate specificities were determined by observing their growth on n-alkanes and analyzing fatty acid metabolism. The results suggested that the twelve Alk proteins can be categorized into four groups based on their substrate specificity: Alk1p, Alk2p, Alk9p, and Alk10p, which have significant activities to hydroxylate n-alkanes; Alk4p, Alk5p, and Alk7p, which have significant activities to hydroxylate the ω-terminal end of dodecanoic acid; Alk3p and Alk6p, which have significant activities to hydroxylate both n-alkanes and dodecanoic acid; and Alk8p, Alk11p, and Alk12p, which showed faint or no activities to oxidize these substrates. The involvement of Alk proteins in the oxidation of fatty alcohols and fatty aldehydes was also analyzed by measuring viability of the mutant deleted for twelve ALK genes in medium containing dodecanol and by observing growth on dodecanal of a mutant strain, in which twelve ALK genes were deleted along with four fatty aldehyde dehydrogenase genes. It was suggested that ALK gene(s) is/are involved in the detoxification of dodecanol and the assimilation of dodecanal. These results imply that genes encoding CYP52-family P450s have undergone multiplication and diversification in Y. lipolytica for assimilation of various hydrophobic compounds.

  1. Internet interventions for chronic pain including headache: A systematic review

    Directory of Open Access Journals (Sweden)

    Monica Buhrman

    2016-05-01

    Full Text Available Chronic pain is a major health problem and behavioral based treatments have been shown to be effective. However, the availability of these kinds of treatments is scarce and internet-based treatments have been shown to be promising in this area. The objective of the present systematic review is to evaluate internet-based interventions for persons with chronic pain. The specific aims are to do an updated review with a broad inclusion of different chronic pain diagnoses and to assess disability and pain and also measures of catastrophizing, depression and anxiety. A systematic search identified 891 studies and 22 trials were selected as eligible for review. Two of the selected trials included children/youth and five included individuals with chronic headache and/or migraine. The most frequently measured domain reflected in the primary outcomes was interference/disability, followed by catastrophizing. Result across the studies showed a number of beneficial effects. Twelve trials reported significant effects on disability/interference outcomes and pain intensity. Positive effects were also found on psychological variable such as catastrophizing, depression and anxiety. Several studies (n = 12 were assessed to have an unclear level of risk bias. The attrition levels ranged from 4% to 54% where the headache trials had the highest drop-out levels. However, findings suggest that internet-based treatments based on cognitive behavioural therapy (CBT are efficacious measured with different outcome variables. Results are in line with trials in clinical settings. Meta-analytic statistics were calculated for interference/disability, pain intensity, catastrophizing and mood ratings. Results showed that the effect size for interference/disability was Hedge's g = −0.39, for pain intensity Hedge's g = −0.33, for catastrophizing Hedge's g = −0.49 and for mood variables (depression Hedge's g = −0.26.

  2. Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: report of twelve cases and discussion of mechanism of action.

    Science.gov (United States)

    Lee, Bok Y; Al-Waili, Noori; Stubbs, Dean; Wendell, Keith; Butler, Glenn; Al-Waili, Thia; Al-Waili, Ali

    2009-12-06

    Oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus and cardiovascular diseases including hypertension. The low levels of antioxidants accompanied by raised levels of markers of free radical damage play a major role in delaying wound healing. Ultra-low microcurrent presumably has an antioxidant effect, and it was shown to accelerate wound healing. The purpose of the study is to investigate the efficacy of ultra-low microcurrent delivered by the Electro Pressure Regeneration Therapy (EPRT) device (EPRT Technologies-USA, Simi Valley, CA) in the management of diabetes, hypertension and chronic wounds. The EPRT device is an electrical device that sends a pulsating stream of electrons in a relatively low concentration throughout the body. The device is noninvasive and delivers electrical currents that mimic the endogenous electric energy of the human body. It is a rechargeable battery-operated device that delivers a direct current (maximum of 3 milliAmperes) of one polarity for 11.5 minutes, which then switched to the opposite polarity for another 11.5 minutes. The resulting cycle time is approximately 23min or 0.000732 Hz and delivers a square wave bipolar current with a voltage ranging from 5V up to a maximum of 40 V. The device produces a current range of 3 mA down to 100 nA. Twelve patients with long standing diabetes, hypertension and unhealed wounds were treated with EPRT. The patients were treated approximately for 3.5 h/day/5 days a week. Assessment of ulcer was based on scale used by National Pressure Ulcer Advisory Panel Consensus Development Conference. Patients were followed-up with daily measurement of blood pressure and blood glucose level, and their requirement for medications was recorded. Treatment continued from 2-4 months according to their response. Results showed that diabetes mellitus and hypertension were well controlled after using this device, and their wounds were markedly healed (30-100%). The patients

  3. Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action

    Directory of Open Access Journals (Sweden)

    Bok Y. Lee, Noori AL-Waili, Dean Stubbs, Keith Wendell, Glenn Butler, Thia AL-Waili, Ali AL-Waili

    2010-01-01

    Full Text Available Oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus and cardiovascular diseases including hypertension. The low levels of antioxidants accompanied by raised levels of markers of free radical damage play a major role in delaying wound healing. Ultra-low microcurrent presumably has an antioxidant effect, and it was shown to accelerate wound healing. The purpose of the study is to investigate the efficacy of ultra-low microcurrent delivered by the Electro Pressure Regeneration Therapy (EPRT device (EPRT Technologies-USA, Simi Valley, CA in the management of diabetes, hypertension and chronic wounds. The EPRT device is an electrical device that sends a pulsating stream of electrons in a relatively low concentration throughout the body. The device is noninvasive and delivers electrical currents that mimic the endogenous electric energy of the human body. It is a rechargeable battery-operated device that delivers a direct current (maximum of 3 milliAmperes of one polarity for 11.5 minutes, which then switched to the opposite polarity for another 11.5 minutes. The resulting cycle time is approximately 23min or 0.000732 Hz and delivers a square wave bipolar current with a voltage ranging from 5V up to a maximum of 40 V. The device produces a current range of 3 mA down to 100 nA. Twelve patients with long standing diabetes, hypertension and unhealed wounds were treated with EPRT. The patients were treated approximately for 3.5 h/day/5 days a week. Assessment of ulcer was based on scale used by National Pressure Ulcer Advisory Panel Consensus Development Conference. Patients were followed-up with daily measurement of blood pressure and blood glucose level, and their requirement for medications was recorded. Treatment continued from 2-4 months according to their response. Results showed that diabetes mellitus and hypertension were well controlled after using this device, and their wounds were markedly healed (30

  4. GeXP多重PCR技术同时检测12种常见呼吸道病毒%A GeXP based Multiplex RT-PCR Assay for Simultaneous Detection of Twelve Human Respiratory Viruses

    Institute of Scientific and Technical Information of China (English)

    李瑾; 毛乃颖; 秦萌; 胡秀梅; 杨梦婕; 王淼; 张晨; 许文波; 马学军

    2011-01-01

    本研究建立了一种基于GeXP多重基因表达遗传分析系统的多重RT-PCR检测方法,该方法可以同时检测12种呼吸道病毒,包括流感病毒A型和B型、季节性H1N1、副流感病毒1~3型、人鼻病毒、人偏肺病毒、腺病毒、呼吸道合胞病毒A型和B型、人博卡病毒.针对病原体保守区序列设计12种病毒的特异性引物,分别用已验证的阳性标本为模板检验多重体系的特异性.多重检测体系在103拷贝/μL水平可同时检测到12种病毒.另检测24份临床标本,以real-time RT-PCR为参考标准,进一步验证检测体系.结果表明,这种基于GeXP系统的新方法灵敏度高、特异性强,可以快速同时检测12种常见呼吸道病毒.%A GeXP based multiplex RT-PCR assay was developed to simultaneously detect twelve different respiratory viruses types/subtypes including influenza A virus, influenza B virus, influenza A virus sHlNl, parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3 , human rhinovi-rus, human metapneumovirus, adenovirus, respiratory syncytial virus A, respiratory syncytial virus B and human bocavirus. Twelve sets of specific primers were designed based on the conserved sequences of available respiratory-virus sequence database The specificity of the multiplex system was examined by positive specimens confirmed previously. The sensitivity to detect twelve respiratory viruses simultaneously was 103 copies/μL. Twenty four clinical specimens were further detected by this novel assay and the results were compared with that of the real-time RT-PCR. These results showed that this novel assay based on GeXP is a fast, sensitive, and high throughput test for the detection of respiratory virus infections.

  5. Discussion the Theory of "Shi's Twelve Word Life Cultivation Skill"%“施氏十二字养生功”的基础理论探讨

    Institute of Scientific and Technical Information of China (English)

    胡志俊; 王世伟; 施杞; 叶秀兰; 唐占英

    2011-01-01

    目的:探讨施氏十二字养生功理论渊源及作用原理.方法:通过发掘古代医学文献对导引的论述并结合现代医学理论来探讨施氏十二字养生功的作用机理.结果:施氏十二字养生功是在中医传统导引理论指导下通过长期的临床实践创建的养生功,对以颈椎病为主的骨退行性病变引起的疼痛不适等有良好疗效.结论:施氏十二字养生功是防治颈椎病有效方法之一.%Objective: Discussion the origin of "Shi's twelve word life cultivation skill " theory and principle. Methods: To explore the ancient medical literature through the discussion on the guidance and combined with modern medical theory of health work Discussion the theory of "Shi's twelve word life cultivation skill" and it's mechanism. Results: "Shi's twelve word life cultivation skill" is guided in the theory of traditional Chinese medicine under the guidance of clinical practice through long-term work to create the health of the cervical degenerative bone disease mainly caused such pain and discomfort have a good effect. Conclusion: "Shi's twelve-word life-cultivation skill" is an effective method for prevention and treatment of cervical spondylosis.

  6. Flies from L.A., The Sequel: A further twelve new species of Megaselia (Diptera: Phoridae) from the BioSCAN Project in Los Angeles (California, USA)

    OpenAIRE

    Hartop, Emily; Brown, Brian; Disney,R. Henry

    2016-01-01

    Presented are continued results from the BioSCAN Project, an urban biodiversity study sampling primarily from private backyards in Los Angeles, California (USA). Presented are continued results from the BioSCAN Project, an urban biodiversity study sampling primarily from private backyards in Los Angeles, California (USA). Twelve new species of Megaselia (Diptera: Phoridae) are described: M. baileyae, M. friedrichae, M. gonzalezorum, M. joanneae, M. losangelensis, M. phyllissunae, M. p...

  7. Blood-letting punctures at twelve Jing-Well points of the hand can treat cerebral ischemia in a similar manner to mannitol

    Institute of Scientific and Technical Information of China (English)

    Xuan Lu; Zelin Chen; Yi Guo; Liang Gao; Liyuan Jiang; Zhongzheng Li; Jianqiao Fang

    2013-01-01

    A rat model of middle cerebral artery permanent occlusion was established using the modified Longa method. Successfully established model animals were treated by blood-letting puncture at twelve Jing-Well points of the hand, and/or by injecting mannitol into the caudal vein twice daily. Brain tissue was collected at 24, 48 and 72 hours after modeling, and blood was collected through the retinal vein before Evans blue was injected, approximately 1 hour prior to harvesting of brain tissue. Results showed that Evans blue leakage into brain tissue and serum nitric oxide synthase activity were significantly increased in model rats. Treatment with blood-letting punctures at twelve Jing-Well points of the hand and/or injection of mannitol into the caudal vein reduced the amount of Evans blue leakage into the brain tissue and serum nitric oxide synthase activity to varying degrees. There was no significant difference between single treatment and combined treatment. Experimental findings indicate that blood-letting punctures at twelve Jing-Well points of the hand can decrease blood-brain barrier permeability and serum nitric oxide synthase activity in rats following middle cerebral artery occlusion, and its effect is similar to that of mannitol injection alone and Jing-Well points plus mannitol injection.

  8. Effect of Blood-letting Puncture at Twelve Well-Points of Hand on Consciousness and Heart Rate in Patients with Apoplexy

    Institute of Scientific and Technical Information of China (English)

    Guo Yi; Wang Xiuyun; Xu Tangping; Dai Zhihua; Li Yunchen

    2005-01-01

    Objective: To observe the effect of blood-letting puncture at Twelve Well-Points of Hand on consciousness and heart rate in patients with early apoplexy. Method: Under observation were patients with disturbance of consciousness within 3 days after the apoplectic seizure. The patients were divided into a large injury team, a moderate injury team and a mild injury team. Each team was again randomly divided into a puncture group and a control group, with routine treatment in both groups but bloodletting puncture only in the puncture group. Quantitative changes in consciousness, blood pressure and heart rate of the patients were observed. Result: Blood-letting puncture at Twelve Well-Points of Hand can improve the consciousness and raise the systolic pressure in patients of the mild injury team, and accelerate the heart rate in all the patients in the puncture group. Conclusion: Blood-letting puncture at Twelve Well-Points of Hand can improve the consciousness of patients with brain injury in small area.

  9. A Comparison of the Twelve Core Values of Thai People Defined by the Head of the National Council for Peace and Order (NCPO) Found in Thai Private and Public University Students

    Science.gov (United States)

    Ngammuk, Patariya

    2016-01-01

    This study aims to examine the twelve core values of Thai people found in Thai university students. The twelve values consist of the following attributes: 1.Upholding the nation, the religions and the Monarchy 2. Being honest, sacrificial and patient with positive attitude for the common good of the public 3. Being grateful to the parents,…

  10. Haemophilus influenzae Disease (Including Hib) Symptoms

    Science.gov (United States)

    ... Search The CDC Cancel Submit Search The CDC Haemophilus influenzae Disease (Including Hib) Note: Javascript is disabled or ... and Symptoms Recommend on Facebook Tweet Share Compartir Haemophilus influenzae , including Hib, disease causes different symptoms depending on ...

  11. Article Including Environmental Barrier Coating System

    Science.gov (United States)

    Lee, Kang N. (Inventor)

    2015-01-01

    An enhanced environmental barrier coating for a silicon containing substrate. The enhanced barrier coating may include a bond coat doped with at least one of an alkali metal oxide and an alkali earth metal oxide. The enhanced barrier coating may include a composite mullite bond coat including BSAS and another distinct second phase oxide applied over said surface.

  12. Static, Lightweight Includes Resolution for PHP

    NARCIS (Netherlands)

    Hills, M.A.; Klint, P.; Vinju, J.J.

    2014-01-01

    Dynamic languages include a number of features that are challenging to model properly in static analysis tools. In PHP, one of these features is the include expression, where an arbitrary expression provides the path of the file to include at runtime. In this paper we present two complementary analy

  13. Increased strength of the scapular stabilizer and lumbar muscles after twelve weeks of Pilates training using the Reformer machine: A pilot study.

    Science.gov (United States)

    Dos Santos, Núbia Tomain Otoni; Raimundo, Karoline Cipriano; da Silva, Sheila Aparecida; Souza, Lara Andrade; Ferreira, Karoline Carregal; Borges Santo Urbano, Zuleika Ferreira; Gasparini, Andréa Licre Pessina; Bertoncello, Dernival

    2017-01-01

    The aim of this work was to analyze muscle strength in Pilates novices who used the Reformer equipment during twelve training sessions. Twenty-four healthy young female volunteers, who were non-smokers and did not exercise regularly, were split into a control group (mean age 28 ± 4 years and BMI 24.55 ± 3.21 kg/m(2)) and a training group (mean age 29 ± 4 years and BMI 22.69 ± 2.87 kgm(2)). The data were checked for normality using the Kolmogorov-Smirnov test, and were then analyzed using the t-test (p Pilates group). The corresponding values for the lumbar muscles were 53.83 ± 11.66/53.28 ± 11.14 (control group) and 54.75 ± 10.27/64.80 ± 10.20 (Pilates group). After twelve sessions of Pilates with the Reformer equipment, there were improvements in lumbar extensor and scapular stabilizer strength. Several benefits are reported by practitioners of Pilates, but until now, there has been limited scientific evidence of the improvement of strength in the trunk and limbs after application of the technique. Published by Elsevier Ltd.

  14. Mechanisms of action in integrated cognitive-behavioral treatment versus twelve-step facilitation for substance-dependent adults with comorbid major depression.

    Science.gov (United States)

    Glasner-Edwards, Suzette; Tate, Susan R; McQuaid, John R; Cummins, Kevin; Granholm, Eric; Brown, Sandra A

    2007-09-01

    In a population of veterans with co-occurring substance use disorders and concomitant major depressive disorder, the current study compared mechanisms of change and therapeutic effects relevant to both disorders between integrated, dual disorder-specific cognitive behavioral therapy (ICBT) and twelve-step facilitation (TSF). Veterans (N = 148) were given standard pharmacotherapy for depression and were randomly assigned to receive 24 weeks of either TSF or ICBT. Process measures were selected to quantify (1) changes in self-efficacy in ICBT, (2) changes in ability to terminate negative affect in ICBT, (3) twelve-step affiliation (TSA) in TSF, and (4) changes in social support in both conditions. Measures of depression and substance use were administered to all participants before treatment, during treatment, and at the end of treatment. Self-efficacy increased among both TSF and ICBT participants during treatment, whereas self-reported ability to regulate negative affect did not change. Consistent with predictions, TSF participants increased community TSA during treatment, whereas those receiving ICBT reduced TSA. Changes in self-efficacy and TSA were associated with improvement in substance use outcomes at the end of treatment. Hypothesized changes in social support were not supported. Both ICBT and TSF produce improvements in self-efficacy, and these changes are related to substance use outcomes for depressed substance abusers. In TSF, intervention-specific changes in TSA occur during the course of treatment and are related to substance use outcomes.

  15. Effects of dietary crude protein on the growth performance, carcass characteristics and serum biochemical indexes of Lueyang black-boned chickens from seven to twelve weeks of age

    Directory of Open Access Journals (Sweden)

    SK Liu

    2015-03-01

    Full Text Available This study was undertaken to assess dietary crude protein (CP concentration for optimum growth performance and carcass characteristics of Lueyang black-boned chicken. In total, six hundred 42-day-old Lueyang black-boned chicks were randomly assigned to five treatments, each with six replicate pens with ten males and ten females. The birds fed experimental diets with different levels of protein concentration of 120, 140, 160, 180 and 200 g kg-1 from seven to twelve weeks of age respectively. On day of 84, weight gain, feed intake, and feed:gain ratio were measured, and two chickens (one male and one female close to the average weight of all birds in each treatment were selected from each pen and sacrificed to evaluate carcass traits and selected serum biochemical indexes. Dietary CP concentration did not have any significant influence on feed intake (p>0.05. The birds fed the diet with 180 or 160 g kg-1 CP concentration exhibited greater (p<0.05 growth rate, better feed conversion ratio, relative breast weight and albumin concentration in serum than that of those fed other dietary CP concentrations. According to the results of regression analysis, the CP requirements of Lueyang black-boned chicken from seven to twelve weeks of age for optimal weight gain and feed:gain ratio were 174 and 170 g kg-1, respectively.

  16. Lung Disease Including Asthma and Adult Vaccination

    Science.gov (United States)

    ... Healthcare Professionals Lung Disease including Asthma and Adult Vaccination Language: English Español (Spanish) Recommend on Facebook Tweet ... more about health insurance options. Learn about adult vaccination and other health conditions Asplenia Diabetes Heart Disease, ...

  17. Births and deaths including fetal deaths

    Data.gov (United States)

    U.S. Department of Health & Human Services — Access to a variety of United States birth and death files including fetal deaths: Birth Files, 1968-2009; 1995-2005; Fetal death file, 1982-2005; Mortality files,...

  18. 28 CFR 20.32 - Includable offenses.

    Science.gov (United States)

    2010-07-01

    ...., drunkenness, vagrancy, disturbing the peace, curfew violation, loitering, false fire alarm, non-specific charges of suspicion or investigation, and traffic violations (except data will be included on arrests...

  19. Including risk in the balanced scorecard

    African Journals Online (AJOL)

    kirstam

    iiSouthern African Business Review Special Edition Accounting Research 2015. Including risk in the .... customer, internal business process and learning and growth perspectives comprise ...... Boston: Harvard Business School Press. Kaplan ...

  20. Including Indigenous Minorities in Decision-Making

    DEFF Research Database (Denmark)

    Pristed Nielsen, Helene

    Based on theories of public sphere participation and deliberative democracy, this book presents empirical results from a study of experiences with including Aboriginal and Maori groups in political decision-making in respectively Western Australia and New Zealand......Based on theories of public sphere participation and deliberative democracy, this book presents empirical results from a study of experiences with including Aboriginal and Maori groups in political decision-making in respectively Western Australia and New Zealand...

  1. Seroprevalence of Hepatitis A Twelve Years After the Implementation of Toddlers' Vaccination: A Population-Based Study in Israel.

    Science.gov (United States)

    Bassal, Ravit; Weil, Merav; Cohen, Daniel; Sofer, Danit; Mendelson, Ella; Shohat, Tamy

    2017-10-01

    In 1999, Israel became the first country to introduce an inactivated hepatitis A vaccine into its national childhood vaccination program. The objective of the present study was to evaluate the seroprevalence of hepatitis A virus antibodies in the Israeli population before and after the introduction of the program. A cross-sectional serosurvey using the National Serum Bank was conducted on 1883 and 2027 serum samples collected before and after introduction of the vaccine, respectively. Serologic tests for the presence of hepatitis A IgG antibodies were performed using an automated enzyme-linked fluorescent assay. The age-adjusted seroprevalence rates of hepatitis A virus antibodies before implementation of hepatitis A vaccination program were 47.1% [95% confidence interval (CI): 44.7%-49.5%] among Jews and 82.8% (95% CI: 79.6%-85.9%) among Arabs, increasing 12 years after to 67.4% (95% CI: 64.7%-70.0%) and 88.2% (95% CI: 86.1%-90.2%), respectively. The seropositivity rate among Jews and Arabs increased significantly among the cohorts included in the program. However, among Jews, a significant increase in seropositivity was also detected among age groups not included in the vaccination program. The decrease in the incidence of hepatitis A in Israel is a consequence of high vaccine uptake, persistent seropositivity rates after vaccination and the considerable number of people vaccinated beyond the program.

  2. Recent developments in superconducting materials including ceramics

    Energy Technology Data Exchange (ETDEWEB)

    Tachikawa, Kyoji

    1987-06-01

    This report describes the history of superconduction starting in 1911, when the superconducting phenomenon was first observed in murcury, until the recent discovery of superconducting materials with high critical temperatures. After outlining the BCS theory, basic characteristics are discussed including the critical temperature, magnetic field and current density to be reached for realizing the superconducting state. Various techniques for practical superconducting materials are discussed, including methods for producing extra fine multiconductor wires from such superconducting alloys as Nb-Ti, intermetallic Nb/sub 3/Sn compound and V/sub 3/Ga, as well as methods for producing wires of Nb/sub 3/Al, Nb/sub 3/(Al, Ge) and Nb/sub 3/Ge such as continuous melt quenching, electron beam irradiation, laser beam irradiation and chemical evaporation. Characteristics of superconducting ceramics are described, along with their applications including superconducting magnets and superconducting elements. (15 figs, 1 tab, 19 refs)

  3. Electric Power Monthly, August 1990. [Glossary included

    Energy Technology Data Exchange (ETDEWEB)

    1990-11-29

    The Electric Power Monthly (EPM) presents monthly summaries of electric utility statistics at the national, Census division, and State level. The purpose of this publication is to provide energy decisionmakers with accurate and timely information that may be used in forming various perspectives on electric issues that lie ahead. Data includes generation by energy source (coal, oil, gas, hydroelectric, and nuclear); generation by region; consumption of fossil fuels for power generation; sales of electric power, cost data; and unusual occurrences. A glossary is included.

  4. Electrochemical cell structure including an ionomeric barrier

    Energy Technology Data Exchange (ETDEWEB)

    Lambert, Timothy N.; Hibbs, Michael

    2017-06-20

    An apparatus includes an electrochemical half-cell comprising: an electrolyte, an anode; and an ionomeric barrier positioned between the electrolyte and the anode. The anode may comprise a multi-electron vanadium phosphorous alloy, such as VP.sub.x, wherein x is 1-5. The electrochemical half-cell is configured to oxidize the vanadium and phosphorous alloy to release electrons. A method of mitigating corrosion in an electrochemical cell includes disposing an ionomeric barrier in a path of electrolyte or ion flow to an anode and mitigating anion accumulation on the surface of the anode.

  5. Photoirradiation of representative polycyclic aromatic hydrocarbons and twelve isomeric methylbenz[a]anthracene with UVA light: formation of lipid peroxidation.

    Science.gov (United States)

    Xia, Qingsu; Chou, Ming W; Yin, Jun J; Howard, Paul C; Yu, Hongtao; Fu, Peter P

    2006-05-01

    Polycyclic aromatic hydrocarbons (PAHs) are widespread genotoxic environmental pollutants, which require metabolic activation in order to exert biological activities, including mutagenicity and carcinogenicity. Photoactivation is another activation pathway that can lead to PAH genotoxicity. In this paper, we demonstrate that photoirradiation of a series of representative PAHs, with and without bearing a methyl substituent, with UVA light in the presence of methyl linoleate resulted in the formation of methyl linoleate hydroperoxides (a lipid peroxide). The lipid peroxide formation was inhibited by dithiothreitol (DTT) (free radical scavenger), NaN3 (singlet oxygen and free radical scavenger), and superoxide dismutase (SOD) (superoxide scavenger), but was enhanced by the presence of deuterium oxide (D2O) (extends singlet oxygen lifetime). These results suggest that photoirradiation of PAHs by UVA light generates reactive oxygen species (ROS), which induce lipid peroxidation.

  6. The Case for Strategies that Include Men

    African Journals Online (AJOL)

    The Case for Strategies that Include Men. Denise M Roth and .... one set of approaches advocated using medical cri- teria to identify and ... planning, offering services for the prevention and ..... are equipped with the basic minimum needed to respond to ..... Lane SD Television minidramas: social marketing and evaluation in ...

  7. Musculoskeletal ultrasound including definitions for ultrasonographic pathology

    DEFF Research Database (Denmark)

    Wakefield, RJ; Balint, PV; Szkudlarek, Marcin

    2005-01-01

    Ultrasound (US) has great potential as an outcome in rheumatoid arthritis trials for detecting bone erosions, synovitis, tendon disease, and enthesopathy. It has a number of distinct advantages over magnetic resonance imaging, including good patient tolerability and ability to scan multiple joint...

  8. An acoustic finite element including viscothermal effects

    NARCIS (Netherlands)

    Nijhof, M.J.J.; Wijnant, Y.H.; Boer, de A.

    2007-01-01

    In acoustics it is generally assumed that viscous- en thermal boundary layer effects play a minor role in the propagation of sound waves. Hence, these effects are neglected in the basic set of equations describing the sound field. However, for geometries that include small confinements of air or thi

  9. 47 CFR 65.820 - Included items.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Included items. 65.820 Section 65.820 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) INTERSTATE RATE...) Cash working capital. The average amount of investor-supplied capital needed to provide funds for...

  10. Nuclear Chemistry: Include It in Your Curriculum.

    Science.gov (United States)

    Atwood, Charles H.; Sheline, R. K.

    1989-01-01

    Some of the topics that might be included in a nuclear chemistry section are explored. Offers radioactivity, closed shells in nuclei, energy of nuclear processes, nuclear reactions, and fission and fusion as topics of interest. Provided are ideas and examples for each. (MVL)

  11. Including the Excluded: One School for All.

    Science.gov (United States)

    EFA 2000 Bulletin, 1998

    1998-01-01

    This issue of "EFA 2000" focuses on the theme of inclusive education, i.e., including children with disabilities in general education classrooms. The cover story discusses a 1995 UNESCO survey of 63 countries that showed that integration of children with disabilities in regular schools is a declared policy in almost every country.…

  12. Improving Physical Health in Patients With Chronic Mental Disorders: Twelve-Month Results From a Randomized Controlled Collaborative Care Trial.

    Science.gov (United States)

    Kilbourne, Amy M; Barbaresso, Michelle M; Lai, Zongshan; Nord, Kristina M; Bramlet, Margretta; Goodrich, David E; Post, Edward P; Almirall, Daniel; Bauer, Mark S

    2017-01-01

    Persons with chronic mental disorders are disproportionately burdened with physical health conditions. We determined whether Life Goals Collaborative Care compared to usual care improves physical health in patients with mental disorders within 12 months. This single-blind randomized controlled effectiveness study of a collaborative care model was conducted at a midwestern Veterans Affairs urban outpatient mental health clinic. Patients (N = 293 out of 474 eligible approached) with an ICD-9-CM diagnosis of schizophrenia, bipolar disorder, or major depressive disorder and at least 1 cardiovascular disease risk factor provided informed consent and were randomized (February 24, 2010, to April 29, 2015) to Life Goals (n = 146) or usual care (n = 147). A total of 287 completed baseline assessments, and 245 completed 12-month follow-up assessments. Life Goals included 5 weekly sessions that provided semistructured guidance on managing physical and mental health symptoms through healthy behavior changes, augmented by ongoing care coordination. The primary outcome was change in physical health-related quality of life score (Veterans RAND 12-item Short Form Health Survey [VR-12] physical health component score). Secondary outcomes included control of cardiovascular risk factors from baseline to 12 months (blood pressure, lipids, weight), mental health-related quality of life, and mental health symptoms. Among patients completing baseline and 12-month outcomes assessments (N = 245), the mean age was 55.3 years (SD = 10.8; range, 25-78 years), and 15.4% were female. Intent-to-treat analysis revealed that compared to those in usual care, patients randomized to Life Goals had slightly increased VR-12 physical health scores (coefficient = 3.21; P = .01). Patients with chronic mental disorders and cardiovascular disease risk who received Life Goals had improved physical health-related quality of life. ClinicalTrials.gov identifiers: NCT01487668 and NCT01244854.

  13. Risk assessment of K Basin twelve-inch and four-inch drain valve failure from a postulated seismic initiating event

    Energy Technology Data Exchange (ETDEWEB)

    MORGAN, R.G.

    1999-06-23

    The Spent Nuclear Fuel (SNF) Project will transfer metallic SNF from the Hanford 105 K-East and 105 K-West Basins to safe interim storage in the Canister Storage Building in the 200 Area. The initial basis for design, fabrication, installation, and operation of the fuel removal systems was that the basin leak rate which could result from a postulated accident condition would not be excessive relative to reasonable recovery operations. However, an additional potential K Basin water leak path is through the K Basin drain valves. Three twelve-inch drain valves are located in the main basin bays along the north wall. Five four-inch drain valves are located in the north and south loadout pits (NLOP and SLOP), the weasel pit, the technical viewing pit, and the discharge chute pit. The sumps containing the valves are filled with concrete which covers the drain valve body. Visual observations indicate that only the valve's bonnet and stem are exposed above the basin concrete floor for the twelve-inch drain valve and that much less of the valve's bonnet and stem are exposed above the basin concrete floor for the five four-inch drain valves. It was recognized, however, that damage of the drain valve bonnet or stem during a seismic initiating event could provide a potential K Basin water leak path. The objectives of this analysis are to: (1) evaluate the likelihood of damaging the three twelve-inch drain valves located along the north wall of the main basin and the five four-inch drain valves located in the pits from a seismic initiating event, and (2) determine the likelihood of exceeding a specific consequence (initial leak rate) from a damaged valve. The analysis process is a risk-based uncertainty analysis where each variable is modeled using available information and engineering judgement. The uncertainty associated with each variable is represented by a probability distribution (probability density function). Uncertainty exists because of the inherent

  14. Rheumatoid Arthritis and Incidence of Twelve Initial Presentations of Cardiovascular Disease: A Population Record-Linkage Cohort Study in England.

    Directory of Open Access Journals (Sweden)

    Mar Pujades-Rodriguez

    Full Text Available While rheumatoid arthritis is an established risk factor for cardiovascular disease (CVD, our knowledge of how the pattern of risk varies for different cardiovascular phenotypes is incomplete. The association between rheumatoid arthritis and the initial presentation of 12 types of CVDs were examined in a contemporary population of men and women of a wide age range.CALIBER data, which links primary care, hospital and mortality data in England, was analysed. A cohort of people aged ≥18 years and without history of CVD was assembled and included all patients with prospectively recorded rheumatoid arthritis from January 1997, until March 2010, matched with up to ten people without rheumatoid arthritis by age, sex and general practice. The associations between rheumatoid arthritis and the initial presentation of 12 types of CVDs were estimated using multivariable random effects Poisson regression models.The analysis included 12,120 individuals with rheumatoid arthritis and 121,191 comparators. Of these, 2,525 patients with and 18,146 without rheumatoid arthritis developed CVDs during a median of 4.2 years of follow-up. Patients with rheumatoid arthritis had higher rates of myocardial infarction (adjusted incidence ratio [IRR] = 1.43, 95%CI 1.21-1.70, unheralded coronary death (IRR = 1.60, 95%CI 1.18-2.18, heart failure (IRR = 1.61, 95%CI 1.43-1.83, cardiac arrest (HR = 2.26, 95%CI 1.69-3.02 and peripheral arterial disease (HR = 1.36, 95%CI 1.14-1.62; and lower rates of stable angina (HR = 0.83, 95%CI 0.73-0.95. There was no evidence of association with cerebrovascular diseases, abdominal aortic aneurysm or unstable angina, or of interactions with sex or age.The observed associations with some but not all types of CVDs inform both clinical practice and the selection of cardiovascular endpoints for trials and for the development of prognostic models for patients with rheumatoid arthritis.

  15. SKIRT: Stellar Kinematics Including Radiative Transfer

    Science.gov (United States)

    Baes, Maarten; Dejonghe, Herwig; Davies, Jonathan

    2011-09-01

    SKIRT is a radiative transfer code based on the Monte Carlo technique. The name SKIRT, acronym for Stellar Kinematics Including Radiative Transfer, reflects the original motivation for its creation: it has been developed to study the effects of dust absorption and scattering on the observed kinematics of dusty galaxies. In a second stage, the SKIRT code was extended with a module to self-consistently calculate the dust emission spectrum under the assumption of local thermal equilibrium. This LTE version of SKIRT has been used to model the dust extinction and emission of various types of galaxies, as well as circumstellar discs and clumpy tori around active galactic nuclei. A new, extended version of SKIRT code can perform efficient 3D radiative transfer calculations including a self-consistent calculation of the dust temperature distribution and the associated FIR/submm emission with a full incorporation of the emission of transiently heated grains and PAH molecules.

  16. Genetic variation in LINGO-1 (rs9652490) and risk of Parkinson's disease: twelve studies and a meta-analysis.

    Science.gov (United States)

    Wu, Yiwen; Wang, Xinyi; Xu, Wei; Liu, Wenyan; Fang, Fang; Ding, Jianqing; Song, Yanyan; Chen, Shengdi

    2012-07-26

    Studies of the relationship between Parkinson's disease (PD) and rs9652490 SNP in LINGO1 gene have reported inconsistent results. To assess the association between the variant and PD risk, a meta-analysis from 12 case-control studies was performed. A total of 6053 PD cases and 5997 controls in 4 studies among Asians and 8 studies among non-Asians were included. The overall and geographic subgroups analysis was conducted, and odds ratios (OR) and 95% confidence intervals (95%CI) were calculated in the fixed-effects or random-effects model. The combined results of overall analysis showed a lack of association of rs9652490 and PD (fixed-effects model, OR 1.00, 95%CI 0.94-1.06), no matter what genetic model of rs9652490. The separate analysis in patients of Asian origin or non-Asian origin also failed to show any ethnic-dependent association. In conclusion, the present meta-analysis does not support the notion that LINGO1 rs9652490 SNP is a major genetic risk factor for PD.

  17. Periapical cemento-osseous dysplasia: a case report with twelve-year follow-up and review of literature.

    Science.gov (United States)

    Senia, E S; Sarao, M S

    2015-11-01

    To present a case report describing the long-term behaviour of periapical cemento-osseous dysplasia by observing the radiographic changes that took place over a period of 12 years. A review of the pertinent literature is also presented. A healthy 26-year-old white female was referred to the Wilford Hall USAF Medical Center Endodontic Department for evaluation of an asymptomatic radiolucency at the apex of the right mandibular lateral incisor. Following a clinical evaluation that included pulp testing, a diagnosis of periapical cemento-osseous dysplasia (PCOD) was made. No treatment was rendered but follow-up visits were recommended. The patient was subsequently re-evaluated 8 times over a period of 12 years. During that time the lesion changed in appearance, displaying the various phases of PCOD. At the same time, lesions affecting the three adjoining incisors appeared and behaved in a similar manner. At the 12-year recall, the right lateral and both central incisors revealed no evidence of PCOD and an almost normal trabecular pattern of bone could be seen. Misdiagnosis and unnecessary treatment of PCOD may be avoided with careful pulp testing and knowledge of its most common locations of occurrence, radiographic appearances (phases) and benign behaviour. © 2014 International Endodontic Journal. Published by John Wiley & Sons Ltd.

  18. A national evaluation of community-based youth cessation programs: end of program and twelve-month outcomes.

    Science.gov (United States)

    Curry, Susan J; Mermelstein, Robin J; Emery, Sherry L; Sporer, Amy K; Berbaum, Michael L; Campbell, Richard T; Flay, Brian; Warnecke, Richard B

    2013-03-01

    Most youth cessation treatment research consists of efficacy studies in which treatments are evaluated under optimal conditions of delivery. Less is known about the effectiveness of youth cessation treatments delivered in real-world, community based settings. A national sample of 41 community-based youth cessation programs participated in a longitudinal evaluation to identify site, program, and participant characteristics associated with successful cessation. Validated quit rates were comparable to those in randomized controlled trials; 7-day abstinence at the end of program averaged 14% and 30-day abstinence at 12 months averaged 12%. Multivariate GEE models explored predictors of smoking cessation at the end of the programs and at 12 months. Results showed correlates of both short- and long-term cessation. Findings point to the importance of both individual and community-level variables, including motivation, opportunities for and encouragement to engage in activities outside of academics, having youth participate in treatment before they become highly dependent smokers, and community norms and ordinances that discourage youth purchase, use and possession of tobacco. Providing evidence-based treatment to youth in community-based settings results in successful cessation.

  19. Phenolic Compounds, Volatiles, and Sensory Characteristics of Twelve Sweet Cherry (Prunus avium L.) Cultivars Grown in Turkey.

    Science.gov (United States)

    Hayaloglu, Ali Adnan; Demir, Nurullah

    2016-01-01

    The paper reports the phenolic, anthocyanin, and volatile compounds and sensory characteristics of 12 cultivars of sweet cherries including cvs. Belge, Bing, Dalbasti, Durona di Cesena, Lambert, Merton Late, Starks Gold, Summit, Sweetheart, Van, Vista, and 0-900 Ziraat. Eight individual phenolic compounds were determined by the HPLC-DAD method. Among these cherries, cvs. Bing, Durona di Cesena, and Lambert contained higher levels of total individual phenolic compounds than the other cultivars. Six anthocyanins were detected in cherries and cyanidin-3-O-rutinoside was principal and it was the highest level in cv. Bing. The major volatiles found were 1-hexanol, (E)-2-hexen-1-ol, benzylalcohol, hexenal, (E)-2-hexenal, and benzaldehyde. Sensory evaluation of the cherries showed that cvs. Belge, Bing, Dalbasti, and Summit have higher textural and flavor scores than others. It was concluded that the same compounds for phenolic or volatiles profiles of sweet cherries were similar in qualitative; however, quantitative differences were observed in these cultivars.

  20. Rotor assembly including superconducting magnetic coil

    Energy Technology Data Exchange (ETDEWEB)

    Snitchler, Gregory L. (Shrewsbury, MA); Gamble, Bruce B. (Wellesley, MA); Voccio, John P. (Somerville, MA)

    2003-01-01

    Superconducting coils and methods of manufacture include a superconductor tape wound concentrically about and disposed along an axis of the coil to define an opening having a dimension which gradually decreases, in the direction along the axis, from a first end to a second end of the coil. Each turn of the superconductor tape has a broad surface maintained substantially parallel to the axis of the coil.

  1. Electric power monthly, September 1990. [Glossary included

    Energy Technology Data Exchange (ETDEWEB)

    1990-12-17

    The purpose of this report is to provide energy decision makers with accurate and timely information that may be used in forming various perspectives on electric issues. The power plants considered include coal, petroleum, natural gas, hydroelectric, and nuclear power plants. Data are presented for power generation, fuel consumption, fuel receipts and cost, sales of electricity, and unusual occurrences at power plants. Data are compared at the national, Census division, and state levels. 4 figs., 52 tabs. (CK)

  2. Opioid dependence treatment, including buprenorphine/naloxone.

    Science.gov (United States)

    Raisch, Dennis W; Fye, Carol L; Boardman, Kathy D; Sather, Mike R

    2002-02-01

    To review opioid dependence (OD) and its treatment. Pharmacologic treatments, including the use of buprenorphine/naloxone, are presented. Pharmaceutical care functions for outpatient OD treatment are discussed. Primary and review articles were identified by MEDLINE and HEALTHSTAR searches (from 1966 to November 2000) and through secondary sources. Tertiary sources were also reviewed regarding general concepts of OD and its treatment. Relevant articles were reviewed after identification from published abstracts. Articles were selected based on the objectives for this article. Studies of the treatment of OD with buprenorphine were selected based on the topic (pharmacology, pharmacokinetics, adverse reactions) and study design (randomized, controlled clinical trials in patients with OD with active/placebo comparisons and/or comparisons of active OD treatments). Articles regarding pharmacists' activities in the treatment and prevention of OD were reviewed for the pharmaceutical care section. OD is considered a medical disorder with costly adverse health outcomes. Although methadone maintenance treatment (MMT) is cost-effective for OD, only about 12% of individuals with OD receive this treatment. Psychological and pharmacologic modalities are used to treat OD, but patients often relapse. Drug therapy includes alpha 2-agonists for withdrawal symptoms, detoxification regimens with or without opioids, opioid antagonists, and opioid replacement including methadone, levomethadyl acetate, and buprenorphine. The Drug Addiction Treatment Act of 1999 allows for office-based opioid replacement therapies. Sublingual buprenorphine with naloxone can be used in this milieu. Buprenorphine with naloxone is currently under new drug application review with the Food and Drug Administration. Clinical research shows buprenorphine to be equal in effectiveness to methadone, but safer in overdose due to its ceiling effect on respiratory depression. It has lower abuse potential and fewer

  3. MODELOS SOCIALES DE ALUMNOS DE DOCE AÑOS DE LA ESCUELA PRIMARIA DE LA EDUCACIÓN PÚBLICA EN GRECIA SOCIAL MODELS OF TWELVE YEARS OLD STUDENTS OF THE PUBLIC PRIMARY SCHOOL IN GREECE

    Directory of Open Access Journals (Sweden)

    Vassilis Karnavas

    2011-10-01

    Full Text Available La multifacética crisis social que está sufriendo Grecia durante los últimos años, se imprenta, según nuestra opinión, en la manera que los alumnos de doce años optan por sus modelos sociales. La siguiente investigación se enmarca en el ámbito de la temprana socialización política. De los datos que se han coleccionado, se hace evidente que los alumnos griegos en esta edad recogen sus modelos sociales, principalmente, del mundo del espectáculo, mientras áreas como la política y la ciencia se encuentran en nivel bajo entre sus preferencias.The, mainly political, multiplex crisis which Greece is going through during the last years, is also reflects, to our opinion, on the way the twelve year old students choose their social models. The following research is included in the area of Early Political Socialization. The research concludes that Greek students of that age choose their social models mainly from the entertainment industry, while politics and science are in a very low level among their preferences.

  4. Phytoaccumulation of trace elements by wetland plants: 3. Uptake and accumulation of ten trace elements by twelve plant species

    Energy Technology Data Exchange (ETDEWEB)

    Qian, J.H.; Zayed, A.; Zhu, Y.L.; Yu, M.; Terry, N.

    1999-10-01

    Interest is increasing in using wetland plants in constructed wetlands to remove toxic elements from polluted wastewater. To identify those wetland plants that hyperaccumulate trace elements, 12 plant species were tested for their efficiency to bioconcentrate 10 potentially toxic trace elements including As, b, Cd, Cr, Cu, Pb, Mn, Hg, Ni, and Se. Individual plants were grown under carefully controlled conditions and supplied with 1 mg L{sup {minus}1} of each trace element individually for 10 d. Except B, all elements accumulated to much higher concentrations in roots than in shoots. Highest shoot tissue concentrations (mg kg{sup {minus}1} DW) of the various trace elements were attained by the following species: umbrella plant (Cyperus alternifolius L.) for Mn (198) and Cr (44); water zinnia (Wedelia trilobata Hitchc.) for Cd (148) and Ni (80); smartweed (Polygonum hydropiperoides Michx.) for Cu (95) and Pb (64); water lettuce (Pistia stratiotes L.) for Hg (92), As (34), and Se (39); and mare's tail (hippuris vulgaris L.) for B (1132). Whereas, the following species attained the highest root tissue concentrations (mg kg{sup {minus}1} DW); stripped rush (Baumia rubiginosa) for Mn (1683); parrot's feather (Myriophyllum brasiliense Camb.) for Cd (1426) and Ni (1077); water lettuce for Cu (1038), Hg (1217), and As (177); smartweed for Cr (2980) and Pb (1882); mare's tail for B (1277); and monkey flower (Mimulus guttatus Fisch.) for Se (384). From a phytoremediation perspective, smartweed was probably the best plant species for trace element removal from wastewater due to its faster growth and higher plant density.

  5. Twelve Cases of Malignant Hematopathy Treated by Combined Therapy of Hematopoietic Stem Cell Transplantation andChinese Herbal Medicine

    Institute of Scientific and Technical Information of China (English)

    虞荣喜; 周郁鸿; 朱宁希; 沈建平; 胡致平; 罗秀素; 林圣云; 沈一平; 陈均法; 孙洁

    2002-01-01

    Objective:To evaluate the effect of hematopoietic stem cell transplantation combined with Chinese herbal medicine in treating malignant hematopathy.Methods: Allo-bone marrow transplantation (allo-BMT) or allo-peripheral blood stem cell transplantation (allo-PBSCT), with conditioning regimen of 60  Co total body irradiation + Cyclophosphamide (TBI+Cy) or busulfan + cyclophosphamide (Bu+Cy), was used to treat 4 cases of chronic granu locytic leukemia (CGL, 3 of chronic phase and 1 of accelerating phase) and one case of acute non-lymphocytic leukemia (ANLL). And auto-BMT or auto-PBSCT, with conditioning regimen of my leran + cytosino arabinoside +cyclophosphamide (MAC) or MAC+VP16, was used to tr eat 7 cases of hematopathy, including 5 cases of ANLL (3 of CR 1 and 2 of CR 2) and 2 cases of malignant lymphoma (1 of the first occurrence and 1 of relapse). Chinese herbal medicine was given orally to all the 12 patients after transplantation according to TCM Syndrome Differentiation. Results: All patients were successfully engrafted. Within the median follow-up period of 18 (4-70) months, 1 patient (8.3%) died a transplantation-related death, 3 ( 25.0% ) relapsed and 8 (66.7%) survived free of original disease. Conclusion: Auto-BMT or auto-PBSCT in CR 1 stage of acute leukemia could reduce the relapse rate, when there was no matched bone marow donor; allo-BMT or allo-PBSCT in chronic stage could result in long-term disease-free survival of patients; Chinese herbal medicine administration in patients of malignant hematopathy after transplantation might reduce the complications and plays certain rol e in promoting recovery of hematopoietic function.

  6. Comparison of photoacclimation in twelve freshwater photoautotrophs (chlorophyte, bacillaryophyte, cryptophyte and cyanophyte isolated from a natural community.

    Directory of Open Access Journals (Sweden)

    Charles P Deblois

    Full Text Available Different representative of algae and cyanobacteria were isolated from a freshwater habitat and cultivated in laboratory to compare their photoacclimation capacity when exposed to a wide range of light intensity and to understand if this factor may modify natural community dominance. All species successfully acclimated to all light intensities and the response of phytoplankton to increased light intensity was similar and included a decrease of most photosynthetic pigments accompanied by an increase in photoprotective pigment content relative to Chl a. Most species also decreased their light absorption efficiency on a biovolume basis. This decrease not only resulted in a lower fraction of energy absorbed by the cell, but also to a lower transfer of energy to PSII and PSI. Furthermore, energy funnelled to PSII or PSI was also rearranged in favour of PSII. High light acclimated organisms also corresponded to high non-photochemical quenching and photosynthetic electron transport reduction state and to a low Φ'M. Thus photoacclimation processes work toward reducing the excitation pressure in high light environment through a reduction of light absorption efficiency, but also by lowering conversion efficiency. Interestingly, all species of our study followed that tendency despite being of different functional groups (colonial, flagellated, different sizes and of different phylogeny demonstrating the great plasticity and adaptation ability of freshwater phytoplankton to their light environment. These adjustments may explain the decoupling between growth rate and photosynthesis observed above photosynthesis light saturation point for all species. Even if some species did reach higher growth rate in our conditions and thus, should dominate in natural environment with respect to light intensity, we cannot exclude that other environmental factors also influence the population dynamic and make the outcome harder to predict.

  7. Twelve-Month Follow-Up of Dexamethasone Implants for Macular Edema from Various Diseases in Vitrectomized and Nonvitrectomized Eyes

    Science.gov (United States)

    Filho, Paulo Augusto de Arruda Mello; Dias, João Rafael de Oliveira; de Andrade, Gabriel C.; Louzada, Ricardo N.; Ávila, Marcos; Berrocal, Maria; Farah, Michel

    2016-01-01

    Purpose. To evaluate the best-corrected visual acuity (BCVA), central retinal thickness (CRT), and the number of dexamethasone implants needed to treat cystoid macular edema (CME) from various etiologies over 12 months in vitrectomized and nonvitrectomized eyes. Methods. This multicenter retrospective cohort study included 112 patients with CME secondary to retinal diseases treated pro re nata (PRN) with a 0.7 mg intravitreal dexamethasone implant for 12 months. The BCVA, CRT, adverse events, safety data, and number of implants were recorded. Results. Vitrectomized and nonvitrectomized eyes received means of three implants and one implant, respectively, over 12 months (P < 0.001). The mean BCVA of all patients improved from 0.13 at baseline to 0.33 (P < 0.001) 12 months after one (P = 0.001), two (P = 0.041), and three (P < 0.001) implants but not four implants (P = 0.068). The mean baseline CRT decreased significantly (P < 0.001) from 463 to 254 microns after 12 months with one (P < 0.001), two (P = 0.002), and three (P = 0.001) implants but not with four implants (P = 0.114). The anatomic and functional outcomes were not significantly different between vitrectomized and nonvitrectomized eyes. Increased IOP was the most common adverse event (23.2%). Conclusions. Dexamethasone implant administered PRN improved VA and decreased CRT in CME, with possible long-term clinically relevant benefits for treating CME from various etiologies. Vitrectomized eyes needed more implants compared with nonvitrectomized eyes. PMID:27721989

  8. Twelve-Month Follow-Up of Dexamethasone Implants for Macular Edema from Various Diseases in Vitrectomized and Nonvitrectomized Eyes

    Directory of Open Access Journals (Sweden)

    Eduardo A. Novais

    2016-01-01

    Full Text Available Purpose. To evaluate the best-corrected visual acuity (BCVA, central retinal thickness (CRT, and the number of dexamethasone implants needed to treat cystoid macular edema (CME from various etiologies over 12 months in vitrectomized and nonvitrectomized eyes. Methods. This multicenter retrospective cohort study included 112 patients with CME secondary to retinal diseases treated pro re nata (PRN with a 0.7 mg intravitreal dexamethasone implant for 12 months. The BCVA, CRT, adverse events, safety data, and number of implants were recorded. Results. Vitrectomized and nonvitrectomized eyes received means of three implants and one implant, respectively, over 12 months (P<0.001. The mean BCVA of all patients improved from 0.13 at baseline to 0.33 (P<0.001 12 months after one (P=0.001, two (P=0.041, and three (P<0.001 implants but not four implants (P=0.068. The mean baseline CRT decreased significantly (P<0.001 from 463 to 254 microns after 12 months with one (P<0.001, two (P=0.002, and three (P=0.001 implants but not with four implants (P=0.114. The anatomic and functional outcomes were not significantly different between vitrectomized and nonvitrectomized eyes. Increased IOP was the most common adverse event (23.2%. Conclusions. Dexamethasone implant administered PRN improved VA and decreased CRT in CME, with possible long-term clinically relevant benefits for treating CME from various etiologies. Vitrectomized eyes needed more implants compared with nonvitrectomized eyes.

  9. Twelve-year survival of 2-surface composite resin and amalgam premolar restorations placed by dental students.

    Science.gov (United States)

    Naghipur, Safa; Pesun, Igor; Nowakowski, Anthony; Kim, Aaron

    2016-09-01

    Composite resin and amalgam restorations are indicated for the restoration of posterior teeth. With increased esthetic demands, long-term clinical studies are required to evaluate the restorative success and reasons for failure of these materials. The purpose of this retrospective study was to determine the survival and reasons for failure of directly placed 2-surface composite resin restorations and directly placed 2-surface amalgam restorations on premolars placed by Canadian dental students. Using The University of Manitoba's dental management software and paper charts, all 2-surface composite resin and 2-surface amalgam restorations placed on premolars between January 1, 2002, and May 30, 2014, were included. Short-term failure (within 2 years), long-term failure, and reasons for failure were collected. A Kaplan-Meier survival estimate with an associated P value comparing composite resin to amalgam restoration curves was performed using SPSS statistical software. Over 12 years, 1695 composite resin and 1125 amalgam 2-surface premolar restorations were placed. Of these restorations, 134 composite resins (7.9%) and 66 amalgams (5.9%) failed. Short-term failures (2 years or less) consisted of 57 composite resin (4%) and 23 amalgam (2.3%) restorations. Long-term failures (greater than 2 years) consisted of 77 composite resin (4.5%) and 43 amalgam (3.8%) restorations. After 12 years of service, the survival probability of composite resin restorations was 86% and that of amalgam restorations 91.5%. The differences in composite resin and amalgam survival curves were also found to be statistically significant (P=.009 for Log-rank test). The main reasons for failure were recurrent caries and fracture of the tooth being restored. Within the limitations of this study, both composite resin and amalgam restorations had acceptable success rates and similar failure modes. Recurrent caries was still the most common reason for failure. Copyright © 2016 Editorial Council for

  10. Piomiositis en el Hospital San Juan de Dioas, Armenia, Quindío Pyomyositis: report of twelve cases

    Directory of Open Access Journals (Sweden)

    Emilsen Ruiz

    1990-03-01

    Full Text Available

    Se presenta una serie de 12 pacientes con piomiositis, diagnosticados entre 1983 y 1988 en el Hospital Universitario San Juan de Dios, de Armenia, Quindío. Se trata de la casuística más numerosa informada hasta ahora en Colombia sobre esta enfermedad e incluye cuatro casos de etiología diferente al Staphylococcus aureus, a saber: tres por Staphylococcus epidermidis y uno por Klebsiella oxytoca. Clínicamente y por laboratorio no hubo diferencias significativas según la etiología. El antecedente de trauma fue Infrecuente (25%, la utilidad diagnóstica de la determinación de las enzimas séricas dé origen muscular muy baja y el ultrasonido muy útil en la localización del absceso muscular.

    We report on a series of 12 patients with pyomyositis, diagnosed at Hospital Universitario San Juan de Dios, Armenia, Quindío, Colombia, between 1983 and 1988; It Is the most numerous series reported so far in Colombia and It Includes four cases caused by bacteria different from Staphylococcus aureus,  namely: Staphylococcus epidermidis (3 and Klebsiella oxytoca (1 . History of previous trauma was infrequently found (25%; the usefuiness of serum enzymes (Creatine kinase, Lactlc dehydrogenase and Aspartate aminotransferase was poor; ultrasound proved to be helpful in localizing the abscesses.

  11. Inconel 718十二角头螺栓制造工艺技术研究%Study on Manufacturing Technology for Inconel 718 Twelve-Point Bolt

    Institute of Scientific and Technical Information of China (English)

    王玉凤; 刘风雷; 庄宝潼

    2015-01-01

    The material and structure features of Inconel 718 twelve-point bolt are introduced, and key manufacturing technologies, such as hot heading, heat treatment, warm rolling, etc. are analyzed, and optimal technological parameters are obtained. Dimensional in-spection and qualiifcation tests are carried out. The results show that technology designing is rational..%介绍了Inconel 718十二角头螺栓的材料和结构特点,分析了关键制造加工技术,如热镦锻、热处理、滚压螺纹等,确定了合理的工艺参数,并对研制件的尺寸和性能进行了评估,结果表明工艺技术设计合理。

  12. Twelve-month outcomes in patients with retinal vein occlusion treated with low-frequency intravitreal ranibizumab

    Directory of Open Access Journals (Sweden)

    Sakanishi Y

    2016-06-01

    Full Text Available Yoshihito Sakanishi, Ami Lee, Ayumi Usui-Ouchi, Rei Ito, Nobuyuki Ebihara Department of Ophthalmology, Juntendo University Urayasu Hospital, Urayasu City, Chiba, Japan Purpose: The purpose of this study was to determine the clinical efficacy of low-frequency intravitreal ranibizumab to treat macular edema due to retinal vein occlusion (RVO.Patients and methods: This was a retrospective examination of cases that received intravitreal ranibizumab for untreated RVO over a period of 12 months. Instead of the conventional three monthly injections, injections were given once during the introductory period. If the recurrence of macular edema was diagnosed during the monthly visit, additional injections were given as needed. There were 21 eyes of 21 patients with branch RVO (BRVO and ten eyes of ten patients with central RVO (CRVO. The parameters examined included the number of injections over the 12-month period, improvements in best-corrected visual acuity (BCVA, and the central macular thickness (CMT. For BRVO, preinjection parameters that had an effect on the prognosis of BCVA after the 12-month period were also examined.Results: The total mean number of injections over the 12-month period was 3.4 for CRVO and 2.1 for BRVO. For CRVO, the BCVA in log minimum angular resolution changed from a preinjection value of 0.80 to 0.55 at 12 months. For BRVO, the change was from 0.51 to 0.30. For all diseases, BCVA improved after 12 months compared with the preinjection values (P<0.05. There was improvement in the CMT, and the CRVO changed from 765.0 µm at preinjection to 253.5 µm 12 months later. BRVO changed from 524.1 to 250.1 µm, and preinjection BCVA was associated with a prognosis of visual acuity after 12 months of the initial injection (P=0.0485.Conclusion: Even with a low number of injections during the introductory period, there were still improvements in both visual acuity and CMT in RVO patients after 12 months, indicating that it was

  13. Musculoskeletal ultrasound including definitions for ultrasonographic pathology

    DEFF Research Database (Denmark)

    Wakefield, RJ; Balint, PV; Szkudlarek, Marcin

    2005-01-01

    Ultrasound (US) has great potential as an outcome in rheumatoid arthritis trials for detecting bone erosions, synovitis, tendon disease, and enthesopathy. It has a number of distinct advantages over magnetic resonance imaging, including good patient tolerability and ability to scan multiple joints...... pathologies. This article presents the first report from the OMERACT ultrasound special interest group, which has compared US against the criteria of the OMERACT filter. Also proposed for the first time are consensus US definitions for common pathological lesions seen in patients with inflammatory arthritis....

  14. Drug delivery device including electrolytic pump

    KAUST Repository

    Foulds, Ian G.

    2016-03-31

    Systems and methods are provided for a drug delivery device and use of the device for drug delivery. In various aspects, the drug delivery device combines a “solid drug in reservoir” (SDR) system with an electrolytic pump. In various aspects an improved electrolytic pump is provided including, in particular, an improved electrolytic pump for use with a drug delivery device, for example an implantable drug delivery device. A catalytic reformer can be incorporated in a periodically pulsed electrolytic pump to provide stable pumping performance and reduced actuation cycle.

  15. Inlet Guide Vane Wakes Including Rotor Effects

    Science.gov (United States)

    Johnston, R. T.; Fleeter, S.

    2001-02-01

    Fundamental experiments are described directed at the investigation of forcing functions generated by an inlet guide vane (IGV) row, including interactions with the downstream rotor, for application to turbomachine forced response design systems. The experiments are performed in a high-speed research fan facility comprised of an IGV row upstream of a rotor. IGV-rotor axial spacing is variable, with the IGV row able to be indexed circumferentially, thereby allowing measurements to be made across several IGV wakes. With an IGV relative Mach number of 0.29, measurements include the IGV wake pressure and velocity fields for three IGV-rotor axial spacings. The decay characteristics of the IGV wakes are compared to the Majjigi and Gliebe empirical correlations. After Fourier decomposition, a vortical-potential gust splitting analysis is implemented to determine the vortical and potential harmonic wake gust forcing functions both upstream and downstream of the rotor. Higher harmonics of the vortical gust component of the IGV wakes are found to decay at a uniform rate due to viscous diffusion.

  16. Including supplementary elements in a compositional biplot

    Science.gov (United States)

    Daunis-i-Estadella, J.; Thió-Henestrosa, S.; Mateu-Figueras, G.

    2011-05-01

    The biplot is a widely and powerful methodology used with multidimensional data sets to describe and display the relationships between observations and variables in an easy way. Compositional data are vectors with positive components, whose sum is constant because they represent a relative contribution of different parts to a whole; due to this property standard biplots cannot be performed with compositional data, instead of a previous transformation of the data is performed. In this paper, we extend the compositional biplot defined by Aitchison and Greenacre (2002), in order to include in the display supplementary elements which are not used in the definition of the compositional biplot. Different types of supplementary elements are considered: supplementary parts of the composition, supplementary continuous variables external to the composition, supplementary categorical variables and supplementary observations. The projection of supplementary parts of the composition is done by means of the equivalence of clr and lr biplots. The other supplementary projections are done by classical methodology. An application example with a real geological data is included.

  17. Critical point anomalies include expansion shock waves

    Energy Technology Data Exchange (ETDEWEB)

    Nannan, N. R., E-mail: ryan.nannan@uvs.edu [Mechanical Engineering Discipline, Anton de Kom University of Suriname, Leysweg 86, PO Box 9212, Paramaribo, Suriname and Process and Energy Department, Delft University of Technology, Leeghwaterstraat 44, 2628 CA Delft (Netherlands); Guardone, A., E-mail: alberto.guardone@polimi.it [Department of Aerospace Science and Technology, Politecnico di Milano, Via La Masa 34, 20156 Milano (Italy); Colonna, P., E-mail: p.colonna@tudelft.nl [Propulsion and Power, Delft University of Technology, Kluyverweg 1, 2629 HS Delft (Netherlands)

    2014-02-15

    From first-principle fluid dynamics, complemented by a rigorous state equation accounting for critical anomalies, we discovered that expansion shock waves may occur in the vicinity of the liquid-vapor critical point in the two-phase region. Due to universality of near-critical thermodynamics, the result is valid for any common pure fluid in which molecular interactions are only short-range, namely, for so-called 3-dimensional Ising-like systems, and under the assumption of thermodynamic equilibrium. In addition to rarefaction shock waves, diverse non-classical effects are admissible, including composite compressive shock-fan-shock waves, due to the change of sign of the fundamental derivative of gasdynamics.

  18. Reconnection experiments including 3D magnetic nulls

    Science.gov (United States)

    Le, A.; Egedal, J.; Vrublevskis, A.

    2010-11-01

    A rich collection of magnetic reconnection scenarios is possible in three dimensions depending on the topological and geometric structure of the magnetic field [1]. In recent experiments at the Versatile Toroidal Facility (VTF) three-dimensional effects were essential even in nearly axisymmetric plasmas with a non-vanishing toroidal field [2]. To explore reconnection in 3D geometries including magnetic null points, a new adjustable set of coils will be installed in the vacuum chamber of VTF. The range of vacuum magnetic field topologies attainable in VTF will be explored numerically. Plasma reconnection experiments will be run in these configurations, and measurements will be presented if available. [4pt] [1] CE Parnell, et al., (2009) ``Three-Dimensional Magnetic Reconnection, in Magnetic Coupling between the Interior and the Atmosphere of the Sun,'' eds. S.S. Hasan and R.J. Rutten, Springer-Verlag, Heidelberg, Berlin. [0ex] [2] Katz, N. et al., (2010) Phys. Rev. Lett. 104, 255004.

  19. Thermovoltaic semiconductor device including a plasma filter

    Science.gov (United States)

    Baldasaro, Paul F.

    1999-01-01

    A thermovoltaic energy conversion device and related method for converting thermal energy into an electrical potential. An interference filter is provided on a semiconductor thermovoltaic cell to pre-filter black body radiation. The semiconductor thermovoltaic cell includes a P/N junction supported on a substrate which converts incident thermal energy below the semiconductor junction band gap into electrical potential. The semiconductor substrate is doped to provide a plasma filter which reflects back energy having a wavelength which is above the band gap and which is ineffectively filtered by the interference filter, through the P/N junction to the source of radiation thereby avoiding parasitic absorption of the unusable portion of the thermal radiation energy.

  20. CLIC expands to include the Southern Hemisphere

    CERN Multimedia

    Roberto Cantoni

    2010-01-01

    Australia has recently joined the CLIC collaboration: the enlargement will bring new expertise and resources to the project, and is especially welcome in the wake of CERN budget redistributions following the recent adoption of the Medium Term Plan.   The countries involved in CLIC collaboration With the signing of a Memorandum of Understanding on 26 August 2010, the ACAS network (Australian Collaboration for Accelerator Science) became the 40th member of in the multilateral CLIC collaboration making Australia the 22nd country to join the collaboration. “The new MoU was signed by the ACAS network, which includes the Australian Synchrotron and the University of Melbourne”, explains Jean-Pierre Delahaye, CLIC Study Leader. “Thanks to their expertise, the Australian institutes will contribute greatly to the CLIC damping rings and the two-beam test modules." Institutes from any country wishing to join the CLIC collaboration are invited to assume responsibility o...

  1. CERN Technical Training: LABVIEW courses include RADE

    CERN Multimedia

    HR Department

    2009-01-01

    The contents of the "LabView Basic I" and "LabView Intermediate II" courses have recently been changed to include, respectively, an introduction to and expert training in the Rapid Application Development Environment (RADE). RADE is a LabView-based application developed at CERN to integrate LabView in the accelerator and experiment control infrastructure. It is a suitable solution to developing expert tools, machine development analysis and independent test facilities. The course names have also been changed to "LabVIEW Basics I with RADE Introduction" and "LabVIEW Intermediate II with Advanced RADE Application". " LabVIEW Basics I with RADE Introduction" is designed for: Users preparing to develop applications using LabVIEW, or NI Developer Suite; users and technical managers evaluating LabVIEW or NI Developer Suite in purchasing decisions; users pursuing the Certified LabVIEW Developer certification. The course pr...

  2. CERN Technical Training: LABVIEW courses include RADE

    CERN Multimedia

    HR Department

    2009-01-01

    The contents of "LabView Basic I" and "LabView Intermediate II" trainings have been recently changed to include, respectively, an introduction and an expert training on the Rapid Application Development Environment (RADE). RADE is a LabView-based application developed at CERN to integrate LabView in the accelerator and experiment control infrastructure. It is a suitable solution to develop expert tools, machine development analysis and independent test facilities. The course names have also been changed to "LabVIEW Basics I with RADE Introduction" and "LabVIEW Intermediate II with Advanced RADE Application". " LabVIEW Basics I with RADE Introduction" is designed for: Users preparing to develop applications using LabVIEW, or NI Developer Suite; users and technical managers evaluating LabVIEW or NI Developer Suite in purchasing decisions; users pursuing the Certified LabVIEW Developer certification. The course prepare...

  3. CERN Technical Training: LABVIEW courses include RADE

    CERN Multimedia

    HR Department

    2009-01-01

    The contents of the "LabView Basic I" and "LabView Intermediate II" courses have recently been changed to include, respectively, an introduction to and expert training in the Rapid Application Development Environment (RADE). RADE is a LabView-based application developed at CERN to integrate LabView in the accelerator and experiment control infrastructure. It is a suitable solution to developing expert tools, machine development analysis and independent test facilities. The course names have also been changed to "LabVIEW Basics I with RADE Introduction" and "LabVIEW Intermediate II with Advanced RADE Application". " LabVIEW Basics I with RADE Introduction" is designed for: Users preparing to develop applications using LabVIEW, or NI Developer Suite; users and technical managers evaluating LabVIEW or NI Developer Suite in purchasing decisions; users pursuing the Certified LabVIEW Developer certification. The course prepares participants to develop test and measurement, da...

  4. Should Broca's area include Brodmann area 47?

    Science.gov (United States)

    Ardila, Alfredo; Bernal, Byron; Rosselli, Monica

    2017-02-01

    Understanding brain organization of speech production has been a principal goal of neuroscience. Historically, brain speech production has been associated with so-called Broca’s area (Brodmann area –BA- 44 and 45), however, modern neuroimaging developments suggest speech production is associated with networks rather than with areas. The purpose of this paper was to analyze the connectivity of BA47 ( pars orbitalis) in relation to language . A meta-analysis was conducted to assess the language network in which BA47 is involved. The Brainmap database was used. Twenty papers corresponding to 29 experimental conditions with a total of 373 subjects were included. Our results suggest that BA47 participates in a “frontal language production system” (or extended Broca’s system). The BA47  connectivity found is also concordant with a minor role in language semantics. BA47 plays a central role in the language production system.

  5. ACCREDITATION FOR TECHNICAL ABILITIES INCLUDING COMPUTER SKILLS

    Directory of Open Access Journals (Sweden)

    Halit Hami OZ

    2013-01-01

    Full Text Available Sector Skills are defined by state-sponsored, employer-led organizations that cover specific economic sectors in the European Union and other countries in the world to reduce skills gaps and shortages, improve productivity, boost the skills of their sector workforces and improve learning supply. The accreditation and registration systems used by professional bodies raise the profile of the profession. In many countries including the European Union, professional associations are beginning to accept practice-based accreditation, generally as an alternative to their mainstream systems. Besides studying the certain agencies in the European Union for assessing/accreditating practical abilities , Accreditation for practical abilities of Information Communication Technology and Business Management/Language domains developed by Accreditation Council for Practical abilities are also studied in detail as an example to establish a similar agency in Turkey.

  6. AMS at the ANU including biomedical applications

    Energy Technology Data Exchange (ETDEWEB)

    Fifield, L.K.; Allan, G.L.; Cresswell, R.G.; Ophel, T.R. [Australian National Univ., Canberra, ACT (Australia); King, S.J.; Day, J.P. [Manchester Univ. (United Kingdom). Dept. of Chemistry

    1993-12-31

    An extensive accelerator mass spectrometry program has been conducted on the 14UD accelerator at the Australian National University since 1986. In the two years since the previous conference, the research program has expanded significantly to include biomedical applications of {sup 26}Al and studies of landform evolution using isotopes produced in situ in surface rocks by cosmic ray bombardment. The system is now used for the measurement of {sup 10}Be, {sup 14}C, {sup 26}Al, {sup 36}Cl, {sup 59}Ni and {sup 129}I, and research is being undertaken in hydrology, environmental geochemistry, archaeology and biomedicine. On the technical side, a new test system has permitted the successful off-line development of a high-intensity ion source. A new injection line to the 14UD has been established and the new source is now in position and providing beams to the accelerator. 4 refs.

  7. Models of bovine babesiosis including juvenile cattle.

    Science.gov (United States)

    Saad-Roy, C M; Shuai, Zhisheng; van den Driessche, P

    2015-03-01

    Bovine Babesiosis in cattle is caused by the transmission of protozoa of Babesia spp. by ticks as vectors. Juvenile cattle (Babesiosis, rarely show symptoms, and acquire immunity upon recovery. Susceptibility to the disease varies between breeds of cattle. Models of the dynamics of Bovine Babesiosis transmitted by the cattle tick that include these factors are formulated as systems of ordinary differential equations. Basic reproduction numbers are calculated, and it is proved that if these numbers are below the threshold value of one, then Bovine Babesiosis dies out. However, above the threshold number of one, the disease may approach an endemic state. In this case, control measures are suggested by determining target reproduction numbers. The percentage of a particular population (for example, the adult bovine population) needed to be controlled to eradicate the disease is evaluated numerically using Columbia data from the literature.

  8. DEVELOPMENT OF WATER CIRCULATION MODEL INCLUDING IRRIGATION

    Science.gov (United States)

    Kotsuki, Shunji; Tanaka, Kenji; Kojiri, Toshiharu; Hamaguchi, Toshio

    It is well known that since agricultural water withdrawal has much affect on water circulation system, accurate analysis of river discharge or water balance are difficult with less regard for it. In this study, water circulation model composed of land surface model and distributed runoff model is proposed at 10km 10km resolution. In this model, irrigation water, which is estimated with land surface model, is introduced to river discharge analysis. The model is applied to the Chao Phraya River in Thailand, and reproduced seasonal water balance. Additionally, the discharge on dry season simulated with the model is improved as a result of including irrigation. Since the model, which is basically developed from global data sets, simulated seasonal change of river discharge, it can be suggested that our model has university to other river basins.

  9. The surgery of peripheral nerves (including tumors)

    DEFF Research Database (Denmark)

    Fugleholm, Kåre

    2013-01-01

    Surgical pathology of the peripheral nervous system includes traumatic injury, entrapment syndromes, and tumors. The recent significant advances in the understanding of the pathophysiology and cellular biology of peripheral nerve degeneration and regeneration has yet to be translated into improved...... surgical techniques and better outcome after peripheral nerve injury. Decision making in peripheral nerve surgery continues to be a complex challenge, where the mechanism of injury, repeated clinical evaluation, neuroradiological and neurophysiological examination, and detailed knowledge of the peripheral...... nervous system response to injury are prerequisite to obtain the best possible outcome. Surgery continues to be the primary treatment modality for peripheral nerve tumors and advances in adjuvant oncological treatment has improved outcome after malignant peripheral nerve tumors. The present chapter...

  10. CERN Technical Training: LABVIEW courses include RADE

    CERN Multimedia

    HR Department

    2009-01-01

    The contents of the "LabView Basic I" and "LabView Intermediate II" courses have recently been changed to include, respectively, an introduction to and expert training in the Rapid Application Development Environment (RADE). RADE is a LabView-based application developed at CERN to integrate LabView in the accelerator and experiment control infrastructure. It is a suitable solution to developing expert tools, machine development analysis and independent test facilities. The course names have also been changed to "LabVIEW Basics I with RADE Introduction" and "LabVIEW Intermediate II with Advanced RADE Application". " LabVIEW Basics I with RADE Introduction" is designed for: Users preparing to develop applications using LabVIEW, or NI Developer Suite; users and technical managers evaluating LabVIEW or NI Developer Suite in purchasing decisions; users pursuing the Certified LabVIEW Developer certification. The course pr...

  11. Imaging of axial spondyloarthritis including ankylosing spondylitis.

    Science.gov (United States)

    Braun, J; Baraliakos, X

    2011-03-01

    New bone formation of the vertebral column is pathognomonic for ankylosing spondylitis (AS), while acute and/or chronic changes in the sacroiliac joints are relevant for diagnosis. The 'gold standard' for assessment of structural changes in AS are conventional radiographs, while MRI is useful to assess inflammation. Recent MRI studies have shown that the lower half of the thoracic spine is most commonly affected in AS. Scoring tools for spinal inflammation such as the ASspiMRI-a have been proposed, successfully used in large clinical trials and compared in a multireader experiment; none was finally preferred by OMERACT. Quantification of structural spinal AS changes is performed by the modified Stokes AS Spine Score (mSASSS), which evaluates lateral cervical and lumbar radiographs. Two years was identified as the shortest possible follow-up time based on the reliability and sensitivity to change of the mSASSS. A potential disadvantage of the mSASSS is that the thoracic spine is not included. Recent data based on the mSASSS have suggested that tumour necrosis factor blockers do not inhibit radiographic progression in AS. Since the mean radiographic change is reported to be less than 1 syndesmophyte over 2 years, the sensitivity to change of the mSASSS has been questioned. However, in one study where continuous non-steroidal anti-inflammatory drugs use was compared with on-demand use, a difference between these two methods of drug intake was reported. The face and construct validity of the mSASSS has been criticised because a score of ´1´ contains a mixture of osteodestructive (erosions) and osteoproliferative changes (squaring and sclerosis). A new scoring system, the RASSS, which concentrates only on bone formation and which includes the lower part of the thoracic spine is currently being evaluated. The relationship between inflammation and new bone formation in AS has recently been investigated. Low sclerostin and DKK-1 serum levels, both inhibitors of bone

  12. Engine lubrication circuit including two pumps

    Science.gov (United States)

    Lane, William H.

    2006-10-03

    A lubrication pump coupled to the engine is sized such that the it can supply the engine with a predetermined flow volume as soon as the engine reaches a peak torque engine speed. In engines that operate predominately at speeds above the peak torque engine speed, the lubrication pump is often producing lubrication fluid in excess of the predetermined flow volume that is bypassed back to a lubrication fluid source. This arguably results in wasted power. In order to more efficiently lubricate an engine, a lubrication circuit includes a lubrication pump and a variable delivery pump. The lubrication pump is operably coupled to the engine, and the variable delivery pump is in communication with a pump output controller that is operable to vary a lubrication fluid output from the variable delivery pump as a function of at least one of engine speed and lubrication flow volume or system pressure. Thus, the lubrication pump can be sized to produce the predetermined flow volume at a speed range at which the engine predominately operates while the variable delivery pump can supplement lubrication fluid delivery from the lubrication pump at engine speeds below the predominant engine speed range.

  13. Full Boltzmann equations for leptogenesis including scattering

    CERN Document Server

    Hahn-Woernle, F; Wong, Y Y Y

    2009-01-01

    We study the evolution of a cosmological baryon asymmetry produced via leptogenesis by means of the full classical Boltzmann equations, without the assumption of kinetic equilibrium and including all quantum statistical factors. Beginning with the full mode equations we derive the usual equations of motion for the right-handed neutrino number density and integrated lepton asymmetry, and show explicitly the impact of each assumption on these quantities. For the first time, we investigate also the effects of scattering of the right-handed neutrino with the top quark to leading order in the Yukawa couplings by means of the full Boltzmann equations. We find that in our full Boltzmann treatment the final lepton asymmetry can be suppressed by as much as a factor of 1.5 in the weak wash-out regime (K1), the full Boltzmann treatment and the integrated approach give nearly identical final lepton asymmetries (within 10 % of each other at K>3). Finally, we show that the opposing effects of quantum statistics on decays/i...

  14. Extending Newtonian Dynamics to Include Stochastic Processes

    Science.gov (United States)

    Zak, Michail

    2009-01-01

    A paper presents further results of continuing research reported in several previous NASA Tech Briefs articles, the two most recent being Stochastic Representations of Chaos Using Terminal Attractors (NPO-41519), [Vol. 30, No. 5 (May 2006), page 57] and Physical Principle for Generation of Randomness (NPO-43822) [Vol. 33, No. 5 (May 2009), page 56]. This research focuses upon a mathematical formalism for describing post-instability motions of a dynamical system characterized by exponential divergences of trajectories leading to chaos (including turbulence as a form of chaos). The formalism involves fictitious control forces that couple the equations of motion of the system with a Liouville equation that describes the evolution of the probability density of errors in initial conditions. These stabilizing forces create a powerful terminal attractor in probability space that corresponds to occurrence of a target trajectory with probability one. The effect in configuration space (ordinary three-dimensional space as commonly perceived) is to suppress exponential divergences of neighboring trajectories without affecting the target trajectory. As a result, the post-instability motion is represented by a set of functions describing the evolution of such statistical quantities as expectations and higher moments, and this representation is stable.

  15. Odontogenic fibroma, including amyloid and ossifying variants.

    Science.gov (United States)

    Eversole, Lewis R

    2011-12-01

    Sixty-five cases of odontogenic fibroma (OdonF) are herein presented having been segregated into peripheral, extra bony tumors (n = 40) and tumors arising in bone or centrally (n = 25). All cases were characterized microscopically by a fibrous proliferation that varied within and between cases in cellularity and collagen fibril diameter, with intermixed odontogenic epithelial islands and cords. All central lesions presented as well demarcated radiolucencies and resorption of contiguous tooth roots was a common finding. These intraosseous lesions were of the WHO type; the so-called nonWHO type was excluded as all lesions with this diagnosis were devoid of an epithelial component and could be reclassified as other soft tissue fibrogenic tumors. Neither the central tumors nor the peripheral lesions recurred following enucleation/curettage, with a mean follow-up of 4 and 3.4 years respectively. Three distinct microscopic variations were encountered in this series: (1) two cases of OdonF with giant cell reaction, (2) two instances of OdonF with ossifying fibroma; and (3) four instances of OdonF with odontogenic ameloblast-associated protein (ODAM), an amyloid-like protein found deposited adjacent to epithelial cords plus CD1a+/S-100+ Langerhans dendritic cells entwined around the epithelial element. A single instance of the odontogenic fibroma-like hamartoma/enamel hypoplasia syndrome has been included in this series.

  16. Locomotive Assignment Optimization Including Train Delays

    Directory of Open Access Journals (Sweden)

    Sandra Kasalica

    2013-10-01

    Full Text Available Intention– Cyclic locomotive assignment planning is a specific type of organization of locomotive usage, and in fact, it means putting the complete workload to a closed chain, which is repeated periodically. The concept of cyclic locomotive assignment planning type organization in the area of train traction has proven in practice as the best one, but as it is made for in-advance defined timetable and without considering the stochastic nature of the timetable realization process, it leads to incompatibility in using locomotives. Methodology – Methodology defined in this paper contains: research of train delays on the Serbian Railways and Montenegrin Railways networks, analysis of the real system organization of locomotive usage in conditions of train delays, theoretical thesis of solving the problem of optimal cyclic locomotive assignment planning in conditions of train delays, designing of a model with algorithms, preparing the software package, testing the model and program with results, as well as the conclusions drawn from the complete research project. Results– The optimization model of cyclic locomotive assignment planning during the process of making timetable including train delays has been defined. Conclusion –The obtained results have shown as expected, that the larger delays of trains required a larger number of locomotives. However, by using this model it is possible to optimize the required number of locomotives, taking into account the real time delays of trains.

  17. The Twelve Days of Shengdan

    Institute of Scientific and Technical Information of China (English)

    JENNIFER; JETT

    2008-01-01

    On the first day of Christmas,China gaveto me A bird that can say ni hao A partridge in a pear tree has nothing on a caged bird that will greet me in Chinese as I pass by—although I worry that one day I’ll try to engage the bird in conversation and find out it speaks better Chinese than I do.

  18. An Integrated Biochemistry Laboratory, Including Molecular Modeling

    Science.gov (United States)

    Hall, Adele J. Wolfson Mona L.; Branham, Thomas R.

    1996-11-01

    The dilemma of designing an advanced undergraduate laboratory lies in the desire to teach and reinforce basic principles and techniques while at the same time exposing students to the excitement of research. We report here on a one-semester, project-based biochemistry laboratory that combines the best features of a cookbook approach (high success rate, achievement of defined goals) with those of an investigative, discovery-based approach (student involvement in the experimental design, excitement of real research). Individual modules may be selected and combined to meet the needs of different courses and different institutions. The central theme of this lab is protein purification and design. This laboratory accompanies the first semester of biochemistry (Structure and Function of Macromolecules, a course taken mainly by junior and senior chemistry and biological chemistry majors). The protein chosen as the object of study is the enzyme lysozyme, which is utilized in all projects. It is suitable for a student lab because it is easily and inexpensively obtained from egg white and is extremely stable, and its high isoelectric point (pI = 11) allows for efficient separation from other proteins by ion-exchange chromatography. Furthermore, a literature search conducted by the resourceful student reveals a wealth of information, since lysozyme has been the subject of numerous studies. It was the first enzyme whose structure was determined by crystallography (1). Hendrickson et al. (2) have previously described an intensive one-month laboratory course centered around lysozyme, although their emphasis is on protein stability rather than purification and engineering. Lysozyme continues to be the focus of much exciting new work on protein folding and dynamics, structure and activity (3 - 5). This lab course includes the following features: (i) reinforcement of basic techniques, such as preparation of buffers, simple enzyme kinetics, and absorption spectroscopy; (ii

  19. Evaluation of twelve maize (Zea mays L. cultivars for silage Avaliação de doze cultivares de milho (Zea mays L. para silagem

    Directory of Open Access Journals (Sweden)

    Maria Celina Jorge Leme

    2010-12-01

    Full Text Available The experiment was conducted to evaluate the agronomic characteristics and chemical composition of different maize cultivars for ensiling of the plant. Twelve maize cultivar were analyzed in a completely randomized block design, with three block, twelve treatments and three replication. The plot with three lines of six meters long and spacing of 0.8 m were used in all trials. The cycle of the plants of the planting to harvest varied from 105 to 114 days. The height average differed among (P 0.05 for ear by plant number (0.9 to 1.1, dry matter (33.2 to 38.2 %, ether extract (1.9 to 2.5 % and neutral detergent fiber (49.1 to 56.2 %. The dry matter production differed (P O experimento foi realizado com o objetivo de avaliar as características agronômicas e químico-bromatológica de diferentes cultivares de milho para ensilagem. Foram avaliados doze cultivares de milho em delineamento experimental em blocos casualizados, com três blocos, 12 tratamentos e três repetições. As parcelas foram constituídas por três linhas de seis metros de comprimento e espaçamento de 0,8 m entre linhas. O ciclo das plantas, do plantio à colheita, variou de 105 a 114 dias. A altura média diferiu entre os cultivares (P 0,05 entre os cultivares para número de espigas por planta (0,9 a 1,1, teores de matéria seca (33,2 a 38,2 %, de extrato etéreo (1,9 a 2,5 % e de fibra em detergente neutro (49,1 a 56,2 %. A produção de matéria seca diferiu (P < 0,05 entre o cultivar TORK (20,6 t/ha e os cultivares CD-302 (16,4 t/ha e TRAKTOR (15,7 t/ha. O AGN-3150 apresentou o menor teor de fibra em detergente ácido (24,2 % e maior digestibilidade (80,7 %. Todas as cultivares apresentaram características agronômicas e qualitativas adequadas para produção de silagem, destacando-se os cultivares TORK e AGN-3150.

  20. The clinical efficacy of Colgate Total Plus Whitening Toothpaste containing a special grade of silica and Colgate Total Toothpaste for controlling breath odor twelve hours after toothbrushing: a single-use clinical study.

    Science.gov (United States)

    Sharma, Naresh C; Galustians, H Jack; Qaqish, Jimmy; Galustians, Ana; Petrone, Margaret E; Rustogi, Kedar N; Zhang, Yun Po; DeVizio, William; Volpe, Anthony R

    2002-01-01

    The objective of this double-blind clinical study, conducted in harmony with American Dental Association guidelines, was to compare a new dentifrice formulation variant of Colgate Total Toothpaste containing a special grade of silica (Colgate Total Plus Whitening Toothpaste) to the commercially available, ADA-Accepted and clinically proven Colgate Total Toothpaste for controlling breath odor twelve hours after brushing the teeth. Breath odor was evaluated by a panel of three examiners using a nine-point hedonic scale. Following a baseline evaluation of breath odor, prospective study subjects who scored above the threshold value for unpleasant breath odor were stratified by score and randomized into two treatment groups. Subjects were provided with a soft-bristled toothbrush, and brushed their teeth thoroughly in their regular and customary manner with their assigned dentifrice. Subjects refrained from dental hygiene, breath mints or mounthrinses for the next twelve hours, after which they were again evaluated for breath odor. Eighty-three (83) adult male and female subjects from the Mississauga, Ontario, Canada area participated in the study. At twelve hours after brushing their teeth, subjects in both dentifrice treatment groups presented mean breath odor scores which were statistically significantly lower than the mean scores observed at baseline. Importantly, there was no statistical difference between the two dentifrices of the mean twelve-hour breath odor scores. The mean twelve-hour breath scores for the Colgate Total Plus Whitening Toothpaste group and the Colgate Total Toothpaste group were 4.89 and 4.67, respectively, which are within the range of values corresponding to pleasant breath odor. Thus, the results of this double-blind clinical study, conducted according to a protocol which had been approved by the Council on Scientific Affairs of the American Dental Association, support the conclusion that Colgate Total Plus Whitening Toothpaste and Colgate

  1. 试述十二律结合四气理论防治五脏疾病%Prevention and Treatment of Five Zang-organs Diseases with Twelve Temperaments Combining with Siqi Theory

    Institute of Scientific and Technical Information of China (English)

    贺海辉; 雷磊; 吴子明

    2013-01-01

    The study and treatment of the music therapy is very popular in Europe and America. While the Chi-nese traditional music therapy is still in the stage of excavation, both the theory and clinical practice are waiting for exploration and development. Through the formation of twelve temperaments and twelve temperaments system, this article discussed the twelve temperaments which reflect the yin and yang of twelve months, and the five in-ternal organs reflect the yin and yang of the four season . The author thinks that the twelve temperaments can pre-vent and treat diseases of five zang-organs, and puts forward the train of thought of prevention and treatment of five zang-organs diseases with twelve temperaments combining with Siqi theory.%目前音乐疗法在欧美的研究和治疗应用非常普遍,而我国中医音乐疗法还处于挖掘整理阶段,无论是基础理论还是临床实践都有待进一步的探索和发展。本文通过论述十二律的形成和十二律吕制度表明十二律反映十二月阴阳,以及五脏通应自然界四时阴阳,认为十二律能够防治五脏疾病,并提出十二律结合四气防治疾病的思路。

  2. Efficacy of disulfiram and Twelve Step Facilitation in cocaine-dependent individuals maintained on methadone: A randomized placebo-controlled trial

    Science.gov (United States)

    Carroll, Kathleen M.; Nich, Charla; Shi, Julia M.; Eagan, Dorothy; Ball, Samuel A.

    2012-01-01

    Background Cocaine use remains a major problem within methadone maintenance programs. Disulfiram’s efficacy in reducing cocaine use has been demonstrated in several trials, but its relative efficacy among individuals who use versus abstain from alcohol remains unclear Treatment approaches which seek to enhance substance users’ involvement in self-help activities (Twelve Step Facilitation, TSF) have been associated with better outcomes among alcohol and cocaine users, but have rarely been evaluated among methadone-maintained cocaine-opioid users. Methods We conducted a randomized, placebo controlled, double blind (for medication condition), factorial (2×2) trial with 4 treatment conditions: Disulfiram plus TSF, disulfiram plus standard counseling only, placebo plus TSF, and placebo plus standard counseling in the context of a community-based methadone maintenance program. Participants (N=112) received either disulfiram (250 mg/d) or placebo in conjunction with daily methadone maintenance. Results Assignment to TSF was associated with less cocaine use throughout treatment and a higher number of cocaine-negative urines. While there were no significant main effects of disulfiram versus placebo, individuals without an alcohol use disorder demonstrated greater reductions in cocaine use over time when assigned to disulfiram. Conclusions TSF appears feasible in this methadone maintenance program and was associated with modest reductions in cocaine use, an often intractable problem in this setting. Support for the efficacy of disulfiram was weaker, as it appeared effective only for those without a current alcohol use disorder for this sample. PMID:22695473

  3. Polymorphisms in twelve candidate genes are associated with growth, muscle lipid profile and meat quality traits in eleven European cattle breeds.

    Science.gov (United States)

    Sevane, N; Armstrong, E; Wiener, P; Pong Wong, R; Dunner, S

    2014-07-01

    Current customers' demands focus on the nutritional and sensory quality of cattle meat. Candidate gene approach allows identification of genetic polymorphisms that have a measurable effect on traits of interest. The aim of this work is to identify new molecular markers for beef production through an association study using 27 candidate genes and 314 purebred bulls from 11 European cattle breeds. Twelve genes were found associated with different lipid and meat quality traits, and among these stand out the considerable effect of CAST on fatness score, CGGBP1 on growth traits, HSPB1 on the percentage of lauric acid (12:0) and phospholipid docosahexaenoic acid (DHA 22:6 n - 3), RORA on the ratio of light absorption (K) to light scattering (S) (K/S), and TNFA on lightness (L*). Most of these traits are related to post-mortem muscle biochemical changes, which are key factors controlling meat quality and consumers' acceptance. Also, the variations produced on muscle fatty acid profiles, such as those of AANAT, CRH, CSN3, HSPB1, and TNFA, give insights into the genetic networks controlling these complex traits and the possibility of future improvement of meat nutritional quality.

  4. Twelve weeks of BodyBalance® training improved balance and functional task performance in middle-aged and older adults

    Directory of Open Access Journals (Sweden)

    Nicholson VP

    2014-11-01

    Full Text Available Vaughan P Nicholson, Mark R McKean, Brendan J Burkett School of Health and Sport Sciences, University of the Sunshine Coast, Sunshine Coast, QLD, Australia Purpose: The purpose of the study was to evaluate the effect of BodyBalance® training on balance, functional task performance, fear of falling, and health-related quality of life in adults aged over 55 years.Participants and methods: A total of 28 healthy, active adults aged 66±5 years completed the randomized controlled trial. Balance, functional task performance, fear of falling, and self-reported quality of life were assessed at baseline and after 12 weeks. Participants either undertook two sessions of BodyBalance per week for 12 weeks (n=15 or continued with their normal activities (n=13.Results: Significant group-by-time interactions were found for the timed up and go (P=0.038, 30-second chair stand (P=0.037, and mediolateral center-of-pressure range in narrow stance with eyes closed (P=0.017. There were no significant effects on fear of falling or self-reported quality of life.Conclusion: Twelve weeks of BodyBalance training is effective at improving certain balance and functional based tasks in healthy older adults. Keywords: postural control, yoga, tai chi, center of pressure, exercise

  5. Theory of the “New Music” Expressionism Based on Schoenberg’ s Twelve-Tone Music%论“新音乐”的表现主义

    Institute of Scientific and Technical Information of China (English)

    林健丹

    2014-01-01

    The Western music of the 20th century, due to the social change, the influence of the economic recovery and cultural ideological trend, produced extremely complex and changeful music form and cultural form.This article, through the innovation of the 20th century Western new music composing techniques, taking Schoenberg and expressionist music representative of twelve-tone music as an example, discusses the“new music” under the influence of the ideological trend of expressionist music, as well as the“tradition” in the leading position of expressionist music.%20世纪的西方音乐,由于受到社会变动、经济复苏和文化思潮的影响,产生了极其复杂多变的音乐形式和文化形态。本文将借20世纪西方新音乐作曲技法的创新,并以表现主义音乐代表人物勋伯格的十二音音乐为例进行分析,论述了“新音乐”思潮影响下的表现主义音乐,以及“反传统”思想在表现主义音乐中的主导地位。

  6. Barley husk carbon as the fiber coating for the solid-phase microextraction of twelve pesticides in vegetables prior to gas chromatography-mass spectrometric detection.

    Science.gov (United States)

    Liang, Weiqian; Wang, Juntao; Zang, Xiaohuan; Dong, Wenhuan; Wang, Chun; Wang, Zhi

    2017-03-31

    In this work, a barley husk biomaterial was successfully carbonized by hydrothermal method. The carbon had a high specific surface area and good stability. It was coated onto a stainless steel wire through sol-gel technique to prepare a solid-phase microextraction fiber for the extraction of trace levels of twelve pesticides (tsumacide, fenobucarb, indoxacarb, diethofencarb, thimet, terbufos, malathion, thiamethoxam, imidacloprid, buprofezin, acetamiprid, thiamethoxam) from vegetable samples prior to gas chromatography-mass spectrometric (GC-MS) detection. The main experimental parameters that could influence the extraction efficiency such as extraction time, extraction temperature, sample pH, sample salinity, stirring rate, desorption temperature and desorption time, were investigated. Under the optimized conditions, the linearity was observed in the range of 0.2-75.0μgkg(-1) for tomato samples, and 0.3-60.0μgkg(-1) for cucumber samples, with the correlation coefficients (r) ranging from 0.9959 to 0.9983. The limits of detection of the method were 0.01-0.05μgkg(-1) for tomato samples, and 0.03-0.10μgkg(-1) for cucumber samples. The recoveries of the analytes for the method from spiked samples were in the range of 76%-104%, and the precision, expressed as the relative standard deviations, was less than 12%. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Discussion on the Rhetoric of Libretto in Twelve Muqam%浅谈《十二木卡姆》唱词的修辞性

    Institute of Scientific and Technical Information of China (English)

    李芸

    2015-01-01

    木卡姆语言的佳妙,除了配合歌腔旋律的演唱外,还表现出了其驾驭文字的艺术手法。论文从不同木卡姆剧本中搜寻出最常用的修辞格,并例举若干例子分别说明这些修辞格在作品中的作用及其相关的问题,试图从修辞立场来研读木卡姆语言的艺术成果。%Twelve Muqam’s libretto showed the writing art, excepting with the song melody singing cavity. We searched most commonly used figures of speech from the script of a different Maqam, and cited a number of examples to illustrate the role of rhetorical devices in his works and their associated problems. We will try to study Muqam language art achievements from from the perspective of rhetoric.

  8. A Randomized Controlled Trial of Puncturing and Bloodletting at Twelve Hand Jing Points to Treat Acute Carbon Monoxide Poisoning as Adjunct to First Aid Treatment: A Study Protocol

    Directory of Open Access Journals (Sweden)

    Ying Yue

    2015-01-01

    Full Text Available Background. Acute carbon monoxide poisoning (ACOP is a significant cause of morbidity and mortality in many countries. Twelve Hand Jing Points (THJP have been believed to be effective to treat all kinds of emergency calls in traditional Chinese medicine (TCM for more than 3000 years. This randomized controlled trial (RCT is designed to evaluate the effectiveness of THJP in curing acute carbon monoxide poisoning in first aid treatment. This paper reports the protocol of the trial. Methods/Design. This RCT is a multicenter, randomized, controlled study undergoing in China. The compliant patients are divided into the bloodletting group and standard of care group. With first aid treatments given to both of the groups, the bloodletting group is bleeding at THJP upon being hospitalized. Primary outcomes and secondary outcomes will be measured and compared between these two groups. Before treatment, immediately after treatment, and 30 minutes, 1 hour, and 4 hours after treatment, patients’ basic vital signs and state of consciousness were observed. Before treatment and 1 and 4 hours after treatment, carboxyhemoglobin concentration in venous blood samples was detected. Discussion. The objective of this study is to provide convincing evidence to clarify the efficacy and safety of THJP for early treatment of acute carbon monoxide poisoning.

  9. Liberdade e compulsão: uma análise da programação dos doze passos dos alcoólicos anônimos Freedom and compulsion: an analysis of twelve steps programming of alcoholics anonymous

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    Joelson Tavares Rodrigues

    2002-06-01

    Full Text Available O presente trabalho se propõe a questionar se a admissão da impotência, inserida nos Doze Passos dos Alcoólicos Anônimos, se confronta com a noção sartreana de liberdade, marcando uma posição tomada pelo AA de entender o alcoolismo como uma compulsão, em que somente a ação de uma força externa pode proporcionar a recuperação. Os autores concluem que, se a programação dos Doze Passos tem sido tão repleta de êxitos, é porque ela, mesmo sem disso dar-se conta, vem trabalhando com a dimensão da escolha, que permite que cada um possa, a todo momento, determinar seu destino.The present paper aims to question if the admission of impotence, included in the twelve steps of alcoholics anonymous, it is against Sartre’s notion of freedom, indicating a position taken by AA of understanding alcoholism as a compulsion, where only the action of an external power can provide recuperation. The authors conclude that, if the programming of twelve steps has been having so effective is because, even when not aware, it has been working with the dimension of choice that allows that each person can at every moment determinate his own destiny.

  10. Ionic liquids, electrolyte solutions including the ionic liquids, and energy storage devices including the ionic liquids

    Energy Technology Data Exchange (ETDEWEB)

    Gering, Kevin L.; Harrup, Mason K.; Rollins, Harry W.

    2015-12-08

    An ionic liquid including a phosphazene compound that has a plurality of phosphorus-nitrogen units and at least one pendant group bonded to each phosphorus atom of the plurality of phosphorus-nitrogen units. One pendant group of the at least one pendant group comprises a positively charged pendant group. Additional embodiments of ionic liquids are disclosed, as are electrolyte solutions and energy storage devices including the embodiments of the ionic liquid.

  11. Two-year outcome of alcohol interventions in Swedish university halls of residence: a cluster randomized trial of a brief skills training program, twelve-step-influenced intervention, and controls.

    Science.gov (United States)

    Ståhlbrandt, Henriettae; Johnsson, Kent O; Berglund, Mats

    2007-03-01

    High-risk alcohol consumption among university students is well documented. Several types of intervention have proved to be effective in reducing alcohol consumption. This study examines the 2-year outcome of 2 different alcohol intervention programs at university halls of residence. Ninety-eight university halls of residence (with 556 students) were cluster randomized to 2 different intervention groups: a brief skills training program (BSTP) with interactive lectures and discussions, a twelve-step-influenced (TSI) program with didactic lectures by therapists trained in the 12-step approach, and a control group. All students completing the baseline assessment received personalized feedback by mail. Students responded to mailed follow-up questionnaires after 1, 2, and 3 years, including alcohol use disorders identification test (AUDIT; years 2 and 3), short index of problems (SIP), and estimated blood alcohol concentration (eBAC). All groups significantly reduced their AUDIT scores from baseline to the second year follow-up, with no significant differences between the groups. Seventy-seven percent of the students belonged to a population with high-risk consumption, using the AUDIT cut-off scores of 8 and 4 for men and women, respectively. Students with high-risk alcohol consumption showed significant differences in AUDIT score reduction in favor of the BSTP compared with controls, and had a tendency to show better results than the TSI intervention (p=0.06). Similar trends could be seen using SIP and eBAC. The TSI did not differ significantly from the control group within the group of students with high-risk alcohol consumption. This study suggests that a BSTP is effective as an intervention in students with high-risk alcohol consumption.

  12. Histological findings in unclassified sudden infant death, including sudden infant death syndrome.

    Science.gov (United States)

    Liebrechts-Akkerman, Germaine; Bovée, Judith V M G; Wijnaendts, Liliane C D; Maes, Ann; Nikkels, Peter G J; de Krijger, Ronald R

    2013-01-01

    Our objective was to study histological variations and abnormalities in unclassified sudden infant death (USID), including sudden infant death syndrome (SIDS), in The Netherlands. Two hundred Dutch USID cases between 1984 and 2005 were identified. The histology slides and autopsy reports of 187 cases were available for systematic review, including brain autopsy in 135 cases. An explanation for the cause of death in 19 patients (10.2%) was found. Twelve patients had bronchopneumonia, 3 showed extensive aspiration, 2 had signs of a metabolic disorder, 1 had sepsis, and 1 had meningitis. Frequent nonspecific findings were congestion (66%), edema (47%), small hemorrhages (18%), and lymphoid aggregates (51%) in the lungs; congestion of the liver (23%); and asphyctic bleeding in the kidney (44%), adrenal gland (23%), and thymus (17%). Statistical associations were found for infection with starry sky macrophages in the thymus (P  =  0.004), with calcification (P  =  0.023), or with debris in the Hassal's corpuscles (P  =  0.034). In this study, in 10.2% of cases the histological findings were incompatible with SIDS or USID. Furthermore, several frequent nonspecific histological findings in the thymus that point toward an infection were found.

  13. Correspondence between future-included and future-not-included theories

    CERN Document Server

    Nagao, Keiichi

    2013-01-01

    We briefly review the correspondence principle proposed in our previous paper, which claims that if we regard a matrix element defined in terms of the future state at time $T_B$ and the past state at time $T_A$ as an expectation value in the complex action theory whose path runs over not only past but also future, the expectation value at the present time $t$ of a future-included theory for large $T_B-t$ and large $t-T_A$ corresponds to that of a future-not-included theory with a proper inner product for large $t-T_A$. This correspondence principle suggests that the future-included theory is not excluded phenomenologically.

  14. Cubitene: an irregular twelve-membered-ring diterpene from a termite soldier. [1,5-dimethyl-8,10-bis(isopropenyl)cyclododeca-1,5-diene

    Energy Technology Data Exchange (ETDEWEB)

    Prestwich, G.D. (International Centre of Insect Physiology and Ecology, Nairobi, Kenya); Wiemer, D.F.; Meinwald, J.; Clardy, J.

    1978-04-12

    Cubitene was isolated from the hexane extract of C. umbratus soldier heads by chromatography over Florisil followed by preparative GLC. High resolution mass spectroscopy indicated the formula of cubitene to be C/sub 20/H/sub 32/. Mass spectra of catalytically hydrogenated cubitene products showed peaks at m/rho 279, consistent with their formulation as substituted cycloalkanes of the composition C/sub 20/H/sub 40/. Cubitene is therefore a monocyclic hydrocarbon with four centers of unsaturation. the /sup 1/H NMR spectral data revealed the presence of two 1,1-disubstituted double bonds, and two additional olefinic protons. Four methyl groups attached to double bonds are also observed. The /sup 13/C NMR spectrum indicated the presence of two tribsubstituted double bonds. Fortunately, cubitene could be obtained in crystalline form (mp 34.5-35/sup 0/C) from cold methanol, allowing a single-crystal x-ray diffraction analysis. It crystallized in the monoclinic crystal class. Lattice parameters were: a = 15.963 (5), b = 6.799 (2), c = 17.038 (5) A; theta = 96.99 (2)/sup 0/. Evidence shows cubitene to be 1,5-dimethyl-8,10-bis(isopropenyl)cyclododeca-1,5-diene, a structure in which one isoprene unit is irregularly joined to three others. It appears to be the first example of a diterpene hydrocarbon based on a twelve-membered carbocyclic ring. Its biosynthesis poses interesting problems. Two possible biosynthetic routes are suggested. An even more basic question remains....whether termite soldiers synthesize cubitene at all, or whether they simply sequester it (or a closely related precursor) from their food.

  15. Text messaging interventions for individuals with mental health disorders including substance use: A systematic review.

    Science.gov (United States)

    Watson, Tyler; Simpson, Scot; Hughes, Christine

    2016-09-30

    We completed a systematic review of the literature to characterize the impact of text messaging interventions on medication adherence or mental health related outcomes in people with mental health disorders including substance use. Four electronic databases were searched from January 1999 to October 2015. Seven studies met our inclusion criteria: three studies evaluated text messaging in patients with schizophrenia or schizoaffective disorder diagnosis, two studies evaluated text messaging in patients with chronic alcohol dependence, and two studies reviewed text messaging in patients with mood disorders. Six studies were randomized controlled trials and one was a prospective pilot study with pre-post intervention design. Text messaging frequency ranged from once weekly to twelve per day. The effect of text messaging on medication adherence was measured in five studies; one study reporting significant improvements in the text messaging intervention group. The effect of text messaging on mental health related outcomes was measured in all seven studies, with five studies showing significant improvements in a variety of psychiatric and social functioning assessments. Collectively, these studies suggest text messaging is a promising tool to support management of patients with mental illness. Further research examining theory-based text messaging interventions in larger samples of patients is required.

  16. Electrolyte solutions including a phosphoranimine compound, and energy storage devices including same

    Energy Technology Data Exchange (ETDEWEB)

    Klaehn, John R.; Dufek, Eric J.; Rollins, Harry W.; Harrup, Mason K.; Gering, Kevin L.

    2017-09-12

    An electrolyte solution comprising at least one phosphoranimine compound and a metal salt. The at least one phosphoranimine compound comprises a compound of the chemical structure ##STR00001## where X is an organosilyl group or a tert-butyl group and each of R.sup.1, R.sup.2, and R.sup.3 is independently selected from the group consisting of an alkyl group, an aryl group, an alkoxy group, or an aryloxy group. An energy storage device including the electrolyte solution is also disclosed.

  17. Levels of nutrients in the leaves of twelve genotypes of grape Teores foliares de nutrientes em doze genótipos de videira

    Directory of Open Access Journals (Sweden)

    Almy Junior Cordeiro de Carvalho

    2010-12-01

    Full Text Available The objective of this study was to characterize the levels of mineral nutrients: N, P, K, Ca, Mg, S, Mn, Fe, Zn, Cu, Mo and B of twelve genotypes of grapevine: 'Italy', 'Ruby' , 'Patricia', 'Isabel', 'Redglobe', 'Roberta', 'Kyoho', 'Roman', 'Rosalinda', 'Moscatel de Hamburgo’,' 'Niagara Rosada' and 'UVF 01' in the North of Rio de Janeiro State. The plants were pruinned and fertilized (organic and mineral. The leaf blades were analyzed in two periods of the reproductive cycle of the vine: in full bloom and the beginning of berry ripening (veraison. In this characterization, it was concluded that the leaves reflected the nutritional status of the vine genotypes. The genotypes did not show levels of N below normal, with most genotypes showing normal levels. Neither genotype showed below normal levels of K and P. All genotypes showed levels of Ca below the normal range for all seasons and Mg in the normal range. All genotypes showed normal levels of B.O objetivo deste trabalho foi o de caracterizar o teor de nutrientes minerais: N, P, K, Ca, Mg, S, Mn, Fe, Zn, Cu, Mo e B de doze genótipos de videira: ‘Itália’, ‘Rubi’, ‘Patrícia’, ‘Isabel’, ‘Redglobe’, ‘Roberta’, ‘Kyoho’, ‘Romana’, ‘Rosalinda’, ‘Moscatel de Hamburgo’, ‘Niágara Rosada’ e ‘UVF 01’ na região Norte Fluminense. Realizou-se a poda, seguida de adubação convencional e orgânica e análise do limbo foliar em duas épocas do ciclo reprodutivo da videira: no pleno florescimento e início da maturação das bagas (“veraison”. Nessa caracterização, concluiu-se que o limbo foliar coletado refletiu bem o estado nutricional dos genótipos de videira. Os genótipos não apresentaram níveis de N abaixo do normal, sendo a maioria dos genótipos apresentaram níveis normais. Nenhum genótipo apresentou níveis abaixo do normal de K e P. Todos os genótipos apresentaram níveis de Ca abaixo da faixa normal para as duas épocas amostradas e n

  18. Twelve Weeks of Sprint Interval Training Improves Indices of Cardiometabolic Health Similar to Traditional Endurance Training despite a Five-Fold Lower Exercise Volume and Time Commitment.

    Directory of Open Access Journals (Sweden)

    Jenna B Gillen

    Full Text Available We investigated whether sprint interval training (SIT was a time-efficient exercise strategy to improve insulin sensitivity and other indices of cardiometabolic health to the same extent as traditional moderate-intensity continuous training (MICT. SIT involved 1 minute of intense exercise within a 10-minute time commitment, whereas MICT involved 50 minutes of continuous exercise per session.Sedentary men (27±8y; BMI = 26±6kg/m2 performed three weekly sessions of SIT (n = 9 or MICT (n = 10 for 12 weeks or served as non-training controls (n = 6. SIT involved 3x20-second 'all-out' cycle sprints (~500W interspersed with 2 minutes of cycling at 50W, whereas MICT involved 45 minutes of continuous cycling at ~70% maximal heart rate (~110W. Both protocols involved a 2-minute warm-up and 3-minute cool-down at 50W.Peak oxygen uptake increased after training by 19% in both groups (SIT: 32±7 to 38±8; MICT: 34±6 to 40±8ml/kg/min; p<0.001 for both. Insulin sensitivity index (CSI, determined by intravenous glucose tolerance tests performed before and 72 hours after training, increased similarly after SIT (4.9±2.5 to 7.5±4.7, p = 0.002 and MICT (5.0±3.3 to 6.7±5.0 x 10-4 min-1 [μU/mL]-1, p = 0.013 (p<0.05. Skeletal muscle mitochondrial content also increased similarly after SIT and MICT, as primarily reflected by the maximal activity of citrate synthase (CS; P<0.001. The corresponding changes in the control group were small for VO2peak (p = 0.99, CSI (p = 0.63 and CS (p = 0.97.Twelve weeks of brief intense interval exercise improved indices of cardiometabolic health to the same extent as traditional endurance training in sedentary men, despite a five-fold lower exercise volume and time commitment.

  19. Electric-dipole-coupled H2O@C60 dimer: Translation-rotation eigenstates from twelve-dimensional quantum calculations

    Science.gov (United States)

    Felker, Peter M.; Bačić, Zlatko

    2017-02-01

    We report on variational solutions to the twelve-dimensional (12D) Schrödinger equation appertaining to the translation-rotation (TR) eigenstates of H2O@C60 dimer, associated with the quantized "rattling" motions of the two encapsulated H2O molecules. Both H2O and C60 moieties are treated as rigid and the cage-cage geometry is taken to be fixed. We consider the TR eigenstates of H2O@C60 monomers in the dimer to be coupled by the electric dipole-dipole interaction between water moieties and develop expressions for computing the matrix elements of that interaction in a dimer basis composed of products of monomer 6D TR eigenstates reported by us recently [P. M. Felker and Z. Bačić, J. Chem. Phys. 144, 201101 (2016)]. We use these expressions to compute TR Hamiltonian matrices of H2O@C60 dimer for two values of the water dipole moment and for various dimer geometries. 12D TR eigenstates of the dimer are then obtained by filter diagonalization. The results reveal two classes of eigenstates, distinguished by the leading order (first or second) at which dipole-dipole coupling contributes to them. The two types of eigenstates differ in the general magnitude of their dipole-induced energy shifts and in the dependence of those shifts on the value of the water dipole moment and on the distance between the H2O@C60 monomers. The dimer results are also found to be markedly insensitive to any change in the orientations of the C60 cages. Finally, the results lend some support for the interpretation that electric dipole-dipole coupling is at least partially responsible for the apparent reduced-symmetry environment experienced by H2O in the powder samples of H2O@C60 [K. S. K. Goh et al., Phys. Chem. Chem. Phys. 16, 21330 (2014)], but only if the water dipole is taken to have a magnitude close to that of free water. The methodology developed in the paper is transferable directly to the calculation of TR eigenstates of larger H2O@C60 assemblies, that will be required for more

  20. Blood Pressure, Sleep Quality and Fatigue in Shift Working Police Officers: Effects of a Twelve Hour Roster System on Cardiovascular and Sleep Health

    Directory of Open Access Journals (Sweden)

    Jaymen L. Elliott

    2016-01-01

    Full Text Available Background: Police officers have been reported to exhibit a high incidence of pathologies, which present prematurely in an otherwise healthy population. Shift work has also been associated with an increased risk of cardiovascular and sleep disorders, attributable to its propensity for circadian rhythm dysfunction. However, contention exists as to whether shift work has a direct effect upon blood pressure (BP regulation. Methods: This cross-sectional study sought to determine changes in BP and associations with the overall sleep quality and fatigue in 206 general duties police officers (n = 140 males of the New South Wales Police Force in Australia. The subjects’ BP was assessed before and after their twelve hour shift, during which time they also completed the Lifestyle Appraisal Questionnaire, Pittsburgh Sleep Quality Index (PSQI, Epworth Sleepiness Scale and Fatigue Severity Scale (FSS. Results: Poor sleep quality (PSQI and fatigue severity (FSS were found to predominate in the sample (69% and 51% respectively. Although there was no change in BP for male participants, female officers’ systolic blood pressure (SBP was found to increase significantly across the shift (p < 0.001, but with no change found in females’ diastolic blood pressure (DBP. Finally, higher pre and post-shift SBP (r = −0.26, p = 0.001; r = −0.25, p = 0.001, respectively and DBP (r = −0.26, p = 0.001; r = −0.26, p = 0.001, respectively were significantly correlated with lower FSS scores after accounting for age, waist-hip ratio and lifestyle risk factors. Conclusions: Based on these preliminary findings, there was a significant increase in SBP of female police officers after shift work, while BP and fatigue levels in all police officers were strongly related. Moreover, the predominating poor sleep quality and impact of fatigue in this sample remain a concern. Further research is required to ensure the physiological welfare of police officers, while strategies

  1. Knee kinematics and kinetics in former soccer players with a 16-year-old ACL injury – the effects of twelve weeks of knee-specific training

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    Holmström Eva

    2007-04-01

    Full Text Available Abstract Background Training of neuromuscular control has become increasingly important and plays a major role in rehabilitation of subjects with an injury to the anterior cruciate ligament (ACL. Little is known, however, of the influence of this training on knee stiffness during loading. Increased knee stiffness occurs as a loading strategy of ACL-injured subjects and is associated with increased joint contact forces. Increased or altered joint loads contribute to the development of osteoarthritis. The aim of the study was to determine if knee stiffness, defined by changes in knee kinetics and kinematics of gait, step activity and cross-over hop could be reduced through a knee-specific 12-week training programme. Methods A 3-dimensional motion analysis system (VICON and a force plate (AMTI were used to calculate knee kinetics and kinematics before and after 12 weeks of knee-specific training in 12 males recruited from a cohort with ACL injury 16 years earlier. Twelve uninjured males matched for age, sex, BMI and activity level served as a reference group. Self-reported patient-relevant data were obtained by the KOOS questionnaire. Results There were no significant changes in knee stiffness during gait and step activity after training. For the cross-over hop, increased peak knee flexion during landing (from 44 to 48 degrees, p = 0.031 and increased internal knee extensor moment (1.28 to 1.55 Nm/kg, p = 0.017 were seen after training, indicating reduced knee stiffness. The KOOS sport and recreation score improved from 70 to 77 (p = 0.005 and was significantly correlated with the changes in knee flexion during landing for the cross-over hop (r = 0.6, p = 0.039. Conclusion Knee-specific training improved lower extremity kinetics and kinematics, indicating reduced knee stiffness during demanding hop activity. Self-reported sport and recreational function correlated positively with the biomechanical changes supporting a clinical importance of the

  2. Cu6S4 cluster based twelve-connected face-centered cubic and Cu19I4S12 cluster based fourteen-connected body-centered cubic topological coordination polymers.

    Science.gov (United States)

    Hao, Zheng-Ming; Fang, Rui-Qin; Wu, Hai-Shun; Zhang, Xian-Ming

    2008-09-15

    Hydrothermal reaction of Cu(MeCO2)2, (4-pyridylthio)acetic acid and NH4SCN resulted in a twelve-connected face-centered cubic topological metal-organic framework [Cu3(pdt)2(CN)] (pdt = pyridinethiolate) in which Cu6S4 clusters act as twelve-connected nodes and pyridine rings and cyanides act as connectors. As an extension, an unprecedented fourteen-connected body-centered cubic coordination polymer [Cu19I4(pdt)12(SH)3] has been synthesized by three methods, in which nanosized chiral Cu19I4S12 clusters act as fourteen-connected nodes and triple pyridine rings and hydrosulfides act as connectors. The in situ S-C(sp(3)), S-C(sp(2)), and S-C(sp) cleavage reactions have been observed in the work.

  3. Variedades de batatinha (Solanum tuberosum L.. I - Comportamento de 12 variedades procedentes da Holanda, Alemanha e Suécia Behavior of twelve potato varieties from European sources

    Directory of Open Access Journals (Sweden)

    O. J. Boock

    1956-01-01

    Full Text Available No presente trabalho são relatadas experiências com 12 variedades de batatinha (Solanum tuberosum L., recebidas da Holanda (Prinslander, Irene, Froma e Barima, Alemanha (Merkur, Sabina, Linda e Concordia e Suécia Konsuragis, Eigenheimer, Voran e Jätte-Bintje. Essas experiências, em número de seis, das quais três no chamado período "da sêca" (março-julho e três no "das águas" (setembro-janeiro, foram executadas nas localidades de Campinas, Louveira o Capão Bonito, no Estado de São Paulo. Ficou evidenciado o seguinte: a dado o bom estado de brotação dos tubérculos, as porcentagens de falhas no plantio "da sêca" foram baixas; já no plantio "das águas", as variedades de brotação lenta, como "Voran" e "Sabina", falharam muito; b "Prinslander" e "Konsuragis" resistiram bem à sêca prolongada, e "Barima" o "Linda" mostraram ser muito sensíveis; c "Linda", "Voran" e "Merkur", principalmente a primeira destas, apresentaram boa resistência a Phytophthora infestans, e "Jätte-Bintje" foi muito suscetível; "Voran", "Irene", "Prinslander" e "Barima" não ofereceram resistência a Alternaria solani; d "Merkur" e "Konsuragis" foram as mais produtivas para as duas épocas de plantio, sendo que "nas águas", "Eigenheimer", "Barima", "Concordia" e Jätte-Bintje", também produziram bem. Outros aspectos relacionados com variedades foram estudados.Twelve potato varieties imported from Holland (Prinslander, Irene, Froma, and Barima, Germany (Merkur, Sabina, Linda, and Concordia, and Sweden (Konsuragis, Eigenheimer, Voran, and Jätte-Bintje were compared in six experiments carried out at three different localities in the state of São Paulo (Campinas, Louveira, and Capão Bonito. The experiments were planted twice a year, once during the so-called dry season (March lo July, and another time during the rainy season (September to March. The following results were obtained: a plantings made in the dry season had a good stand, whereas this was

  4. Prevalencia de caries en una población escolar de doce años Prevalence of caries in an school population of twelve year-old

    Directory of Open Access Journals (Sweden)

    M.A. Tapias Ledesma

    2009-08-01

    Full Text Available El objetivo de este estudio es conocer la prevalencia de caries en una población escolar de 12 años y factores asociados a la misma. Población y métodos: Se ha efectuado un estudio transversal en 452 escolares de 12 años edad de Móstoles. Para determinar el estado dental se ha efectuado una exploración odontológica siguiendo los criterios de la OMS. Medimos la prevalencia de caries en dentición temporal y permanente, así como los índices de caries en dentición temporal (cod, cos y en dentición permanente (CAOD, CAOS, también medimos el índice SiC, calcularemos los intervalos de confianza al 95%. Utilizamos el programa estadístico SPSS V 13 para realizar todos los cálculos estadísticos y epidemiológicos necesarios del estudio. Resultados: La prevalencia en dentición permanente es del 28,8% (IC 95%: 26,94-31,06. El índice CAOD es del 0,61 (IC 95%: 0,48-0,73 y el índice cod 0,33 (IC 95%: 0,24-0,42. El índice SiC es de 1,82 (IC 95%: 1,55-2,09. Como conclusión podemos resaltar que prevalencia de caries en la población de 12 años de Móstoles ha disminuido. Un 71% de los escolares esta libre de caries en dentición permanente.The objective of study is to know the prevalence of dental caries in schoolchildren 12 year-old and associated factors. Population and Methods: A cross sectional observational study has been carried out in 542 twelve year old schoolchildren in Móstoles. We conducted a dental exploration using the World Health Organization criteria. We then measure the caries prevalence permanent and deciduas and the dmt, dmts, DMFT, DMFS index and its confidence limits at 95%. We used programs SPPS V.13 to carry out all the statistic calculations of the study. Results: The caries prevalence in permanent teeth is 28,8% (IC95%: 26,94-31,06. The DMTF index is 0,61 (IC 95%: 0,48-0,73 and the dmt index is 0,33 (IC 95%: 0,24-0,42. SiC index is 1,82 (IC 95%: 1,55-2,09. In conclusion, the caries prevalence in the 12 year old

  5. Multimodality therapy including radiotherapy and chemotherapy improves event-free survival in stage C esthesioneuroblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Eich, H.T.; Staar, S.; Mueller, R.P. [Dept. of Radiotherapy, Univ. of Cologne (Germany); Hero, B.; Berthold, F. [Dept. of Pediatric Oncology, Children' s Hospital, Univ. of Cologne (Germany); Micke, O. [Dept. of Radiotherapy, Univ. of Muenster (Germany); Seegenschmiedt, H. [Dept. of Radiotherapy, Alfried Krupp Hospital, Essen (Germany); Mattke, A. [Children' s Hospital, Olgaspital, Stuttgart (Germany)

    2003-04-01

    Background: To evaluate the efficacy of multimodality therapy in patients with esthesioneuroblastoma (ENB). Patients and Methods: From 01/1979 through 08/2001, 47 patients with ENB (20 men, 27 women, age 5-81 years), were registered from 18 oncologic centers. There were 14 tumors stage B and 33 stage C according to the Kadish classification. Initial treatment included surgery alone in seven patients, radiotherapy (RT) with or without chemotherapy (CTX) in twelve, surgery plus postoperative RT in 15, and multimodality therapy (surgery plus pre- or postoperative CTX plus postoperative RT) in 13. Results: The 5-year overall survival (OS) for the whole group was 64 {+-} 8% and the 5-year event-free survival (EFS) 50 {+-} 8%. Patients with multimodality treatment had a significantly better 5-year EFS (74 {+-} 13%) compared to the other patients (41 {+-} 9%; p = 0.05), while the 5-year OS was not significantly different between the treatment groups (p = 0.39). For patients with Kadish stage C, multimodality therapy (n = 11) resulted in superior 5-year EFS (72 {+-} 14% vs 17 {+-} 9%; p = 0.01). These patients tended to have an improved OS (69 {+-} 15% vs 47 {+-} 12%; p = 0.19) compared to the other treatment groups. None of the patients with multimodality treatment had a metastatic relapse. Conclusion: Multimodality treatment (surgery plus pre- or postoperative CTX plus postoperative RT) appears to be highly efficient in preventing local and systemic relapse in patients with advanced ENB. Timing and optimal agents of CTX need to be further evaluated. (orig.)

  6. Unsterblicher Robin Hood--Eine literaturdidaktische Betrachtung und Wertung von zwoelf Lektueretexten (Immortal Robin Hood--A Pedagogical Consideration and Evaluation of Twelve Reading Texts).

    Science.gov (United States)

    Hoegel, Rolf

    1979-01-01

    Examines 12 reading texts about Robin Hood, with regard to their content, suitability for various age levels, and language difficulty. The texts are found to be best suited for grades 5 and 6. An evaluation of each text is included. (IFS/WGA)

  7. Unsterblicher Robin Hood--Eine literaturdidaktische Betrachtung und Wertung von zwoelf Lektueretexten (Immortal Robin Hood--A Pedagogical Consideration and Evaluation of Twelve Reading Texts).

    Science.gov (United States)

    Hoegel, Rolf

    1979-01-01

    Examines 12 reading texts about Robin Hood, with regard to their content, suitability for various age levels, and language difficulty. The texts are found to be best suited for grades 5 and 6. An evaluation of each text is included. (IFS/WGA)

  8. Should Relational Aggression Be Included in DSM-V?

    Science.gov (United States)

    Keenan, Kate; Coyne, Claire; Lahey, Benjamin B.

    2008-01-01

    The study examines whether relational aggression should be included in DSM-V disruptive behavior disorders. The results conclude that some additional information is gathered from assessing relational aggression but not enough to be included in DSM-V.

  9. Haemophilus influenzae Disease (Including Hib) Diagnosis and Treatment

    Science.gov (United States)

    ... Search The CDC Cancel Submit Search The CDC Haemophilus influenzae Disease (Including Hib) Note: Javascript is disabled or ... Compartir On this Page Diagnosis Treatment Complications Diagnosis Haemophilus influenzae , including Hib, disease is usually diagnosed with one ...

  10. Should Relational Aggression Be Included in DSM-V?

    Science.gov (United States)

    Keenan, Kate; Coyne, Claire; Lahey, Benjamin B.

    2008-01-01

    The study examines whether relational aggression should be included in DSM-V disruptive behavior disorders. The results conclude that some additional information is gathered from assessing relational aggression but not enough to be included in DSM-V.

  11. Partially ionized plasmas including the third symposium on uranium plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Krishnan, M. [ed.

    1976-09-01

    Separate abstracts are included for 28 papers on electrically generated plasmas, fission generated plasmas, nuclear pumped lasers, gaseous fuel reactor research, and applications. Five papers have been previously abstracted and included in ERA.

  12. Faults of Europe including Turkey (flt4_2l)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This coverage includes arcs that describe faults found in the surface outcrops of bedrock of Europe including Turkey (Albania, Andorra, Austria, Belgium, Bosnia and...

  13. In situ synthesis of twelve dialkyltartrate-boric acid complexes and two polyols-boric acid complexes and their applications as chiral ion-pair selectors in nonaqueous capillary electrophoresis.

    Science.gov (United States)

    Wang, Li-Juan; Yang, Juan; Yang, Geng-Liang; Chen, Xing-Guo

    2012-07-27

    In this paper, twelve dialkyltartrate-boric acid complexes and two polyols-boric acid complexes were in situ synthesized by the reaction of different dialkyltartrates or polyols with boric acid in methanol containing triethylamine. All of the twelve dialkyltartrate-boric acid complexes were found to have relatively good chiral separation performance in nonaqueous capillary electrophoresis (NACE). Their chiral recognition effects in terms of both enantioselectivity (α) and resolution (R(s)) were similar when the number of carbon atoms was below six in the alkyl group of alcohol moiety. The dialkyltartrates containing alkyl groups of different structures but the same number of carbon atoms, i.e. one of straight chain and one of branched chain, also provided similar chiral recognition effects. Furthermore, it was demonstrated for the first time that two methanol insoluble polyols, D-mannitol and D-sorbitol, could react with boric acid to prepare chiral ion-pair selectors using methanol as the solvent medium. Copyright © 2012 Elsevier B.V. All rights reserved.

  14. 意象即叙事——评超文本小说《十二蓝》%Imagery as Narrative:On Michael Joyce's Hypertext Twelve Blue

    Institute of Scientific and Technical Information of China (English)

    郭亚娟

    2012-01-01

    在超文本文学创作里,纸质印刷强加于文学叙事的线性秩序荡然无存,超文本的叙事流取决于辞片(即电子页面)间看似随意却极具隐喻性的意象关联。在《十二蓝》中,蓝色调衍化而成的十二条命运之线时而交集,间或并行,统摄超文本叙事的是一条绵延的,向四方无限发散的意象之河。超文本小说的叙事由此超越了传统二维叙事,形成一种独特的立体网状的叙事结构。%In hypertext writing,traditional linear narration of the print literature is replaced by a set of seemingly excursive,yet particularly metaphorical and interrelated images flowing between hypertextual lexias.In Michael Joyce's Twelve Blue,with twelve blue threads of narration/destiny both interweaving and paralleling,the narration of the hypertext is governed by a flowing river of excursive images.Thus a three-dimensional,web-like narrative mode becomes established in hypertext narration,in replacement of the traditional two-dimensional narration.

  15. Screening and quantitative determination of twelve acidic and neutral pharmaceuticals in whole blood by liquid-liquid extraction and liquid chromatography-tandem mass spectrometry

    DEFF Research Database (Denmark)

    Simonsen, Kirsten Wiese; Steentoft, Anni; Buck, Maike

    2010-01-01

    . The method was fully validated for salicylic acid, paracetamol, phenobarbital, carisoprodol, meprobamate, topiramate, etodolac, chlorzoxazone, furosemide, ibuprofen, warfarin, and salicylamide. The method also tentatively includes thiopental, theophylline, piroxicam, naproxen, diclophenac, and modafinil......We describe a multi-method for simultaneous identification and quantification of 12 acidic and neutral compounds in whole blood. The method involves a simple liquid-liquid extraction, and the identification and quantification are performed using liquid chromatography-tandem mass spectrometry...

  16. Prevalence of goiter and urinary iodine status in six-twelve-year-old rural primary school children of Bharuch district, Gujarat, India

    Directory of Open Access Journals (Sweden)

    Haresh Rameshkumar Chandwani

    2012-01-01

    Full Text Available Background: Iodine deficiency disorder (IDD creates major public health problems in India, including Gujarat. The Bharuch district is a known iodine deficiency endemic area. This study was conducted to estimate the prevalence of goiter in primary school children; to determine the median urinary iodine concentration; to assess the level of iodine in salt samples at the household and retail shop levels; and to study the profile of salt sold at retail shops. Methods: This study was carried out by using the 30-cluster survey method in the primary schools of the rural areas in Bharuch district. A total of 70 students, including five boys and five girls from the first to seventh classes, who were present in class on the day of the visit were selected randomly for goiter examination from each village. Urine samples were collected from one boy and one girl from each class in each cluster. From each community, a maximum of two boys and two girls from each standard in the same age group were examined and also salt samples were tested from their households. From each village, one retail shop was visited and the salt purchased from those shops was immediately tested for iodine with spot kits. Results: We found a goiter prevalence of 23.2% (grade 1 - 17.4% and grade 2 - 5.8%. As the age increased, the goiter prevalence decreased except in nine-year-olds. The median urinary iodine excretion level was 110 μg/L. An Iodine level > 15 ppm was found in 93% of the salt samples tested at the household level. Conclusion: The present study showed moderate goiter prevalence in primary school children in the Bharuch district of Gujarat and an inadequate iodine content of salt at some household levels.

  17. Prevalent vitamin B-12 deficiency in twelve-month-old Guatemalan infants is predicted by maternal B-12 deficiency and infant diet.

    Science.gov (United States)

    Jones, Katharine M; Ramirez-Zea, Manuel; Zuleta, Clara; Allen, Lindsay H

    2007-05-01

    Approximately one-third of low-income women and children studied in Guatemala are reported to have deficient (deficiency can adversely affect infant development and cognitive function, the present study examined predictors of deficient plasma vitamin B-12 concentrations at the age of 12 mo. Analyses were performed on baseline data from a randomized clinical trial in 304 Guatemalan infants, 80% of whom were partially breast-fed, and their mothers. Exclusion criteria for infants included twins, severe stunting or moderate wasting, reported major health problems, severe developmental delay, hemoglobin 3 mo. Data collected included socio-economic status, infant anthropometry, vitamin B-12 intake from complementary foods, and breast-feeding frequency reported by mothers. A complete blood count and plasma vitamin B-12, folate, ferritin, and C-reactive protein were measured. Deficient or marginal plasma vitamin B-12 concentrations were found in 49% of infants and 68% of mothers. The mean intake of maternal vitamin B-12 was 3.1 microg/d, and infants consumed 2.2 microg/d from complementary foods. In linear regression analysis, infant plasma B-12 concentration was strongly and positively associated with maternal plasma vitamin B-12 and B-12 intake from complementary foods (predominantly powdered cow's milk), and inversely associated with frequency of breast-feeding and larger household size (P < 0.0001). Vitamin B-12 supplementation of lactating women, food fortification, and education to improve infant's vitamin B-12 status are potential interventions that can improve the vitamin B-12 status of mothers and infants in this population.

  18. Use of Pentamidine As Secondary Prophylaxis to Prevent Visceral Leishmaniasis Relapse in HIV Infected Patients, the First Twelve Months of a Prospective Cohort Study.

    Directory of Open Access Journals (Sweden)

    Ermias Diro

    Full Text Available Visceral leishmaniasis (VL has become an important opportunistic infection in persons with HIV-infection in VL-endemic areas. The co-infection leads to profound immunosuppression and high rate of annual VL recurrence. This study assessed the effectiveness, safety and feasibility of monthly pentamidine infusions to prevent recurrence of VL in HIV co-infected patients.A single-arm, open-label trial was conducted at two leishmaniasis treatment centers in northwest Ethiopia. HIV-infected patients with a VL episode were included after parasitological cure. Monthly infusions of 4 mg/kg pentamidine-isethionate diluted in normal-saline were started for 12 months. All received antiretroviral therapy (ART. Time-to-relapse or death was the primary end point.Seventy-four patients were included. The probability of relapse-free survival at 6 months and at 12 months was 79% and 71% respectively. Renal failure, a possible drug-related serious adverse event, occurred in two patients with severe pneumonia. Forty-one patients completed the regimen taking at least 11 of the 12 doses. Main reasons to discontinue were: 15 relapsed, five died and seven became lost to follow-up. More patients failed among those with a CD4+cell count ≤ 50 cells/μl, 5/7 (71.4% than those with counts above 200 cells/μl, 2/12 (16.7%, (p = 0.005.Pentamidine secondary prophylaxis led to a 29% failure rate within one year, much lower than reported in historical controls (50%-100%. Patients with low CD4+cell counts are at increased risk of relapse despite effective initial VL treatment, ART and secondary prophylaxis. VL should be detected and treated early enough in patients with HIV infection before profound immune deficiency installs.

  19. 20 CFR 404.1312 - World War II service included.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false World War II service included. 404.1312... DISABILITY INSURANCE (1950- ) Wage Credits for Veterans and Members of the Uniformed Services World War II Veterans § 404.1312 World War II service included. Your service was in the active service of the...

  20. 31 CFR 103.51 - Dollars as including foreign currency.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Dollars as including foreign currency... RECORDKEEPING AND REPORTING OF CURRENCY AND FOREIGN TRANSACTIONS General Provisions § 103.51 Dollars as including foreign currency. Wherever in this part an amount is stated in dollars, it shall be deemed to...

  1. 26 CFR 1.1013-1 - Property included in inventory.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 11 2010-04-01 2010-04-01 true Property included in inventory. 1.1013-1 Section... inventory. The basis of property required to be included in inventory is the last inventory value of such property in the hands of the taxpayer. The requirements with respect to the valuation of an inventory...

  2. 7 CFR 1437.303 - Aquaculture, including ornamental fish.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Aquaculture, including ornamental fish. 1437.303... ASSISTANCE PROGRAM Determining Coverage Using Value § 1437.303 Aquaculture, including ornamental fish. (a) Aquaculture is a value loss crop and is compensable only in accord with restrictions set in this...

  3. 25 CFR 20.403 - What do protective services include?

    Science.gov (United States)

    2010-04-01

    .../services, including Child Protection, and/or establishing Multi-Disciplinary Teams. (b) Must include, where... circumstances and abilities and the extent to which the account holder needs assistance in managing his or her financial affairs; and (2) Managing supervised IIM accounts of children and adults (in conjunction with...

  4. Solar Energy Education. Reader, Part II. Sun story. [Includes glossary

    Energy Technology Data Exchange (ETDEWEB)

    1981-05-01

    Magazine articles which focus on the subject of solar energy are presented. The booklet prepared is the second of a four part series of the Solar Energy Reader. Excerpts from the magazines include the history of solar energy, mythology and tales, and selected poetry on the sun. A glossary of energy related terms is included. (BCS)

  5. Making Way and Making Sense: Including Newcomers in Interaction

    Science.gov (United States)

    Pillet-Shore, Danielle

    2010-01-01

    In our everyday interactions as they unfold in real time, how do we do including? This article examines a specific set of interactional moments when the potential to be included (or not) recurs: when a newcomer arrives to some social scene where two or more already-present persons are actively engaged in some activity and that newcomer displays…

  6. Including All Children in Standards-Based Physical Education.

    Science.gov (United States)

    Johnson, Lynn V.; Kasser, Susan L.; Nichols, Beverly A.

    2002-01-01

    Discusses the inclusion of students with and without disabilities in physical education as the movement toward standards-based education progresses, examining whether standards should be applied to all students, obstacles to including all students, ways to include all students, and the importance of standards for teachers. An example of inclusive…

  7. Including Students with Disabilities. ERIC Mini-Bib EB14.

    Science.gov (United States)

    Sorenson, Barbara R., Comp.

    This annotated bibliography lists 19 publications to help educators more effectively include students with disabilities in general education classrooms. The publications, including books, journal articles, videotapes, and reports, are dated from 1993 through 1999, and most are available through the ERIC (Educational Resources Information Center)…

  8. Microfluidic devices and methods including porous polymer monoliths

    Science.gov (United States)

    Hatch, Anson V; Sommer, Gregory J; Singh, Anup K; Wang, Ying-Chih; Abhyankar, Vinay V

    2014-04-22

    Microfluidic devices and methods including porous polymer monoliths are described. Polymerization techniques may be used to generate porous polymer monoliths having pores defined by a liquid component of a fluid mixture. The fluid mixture may contain iniferters and the resulting porous polymer monolith may include surfaces terminated with iniferter species. Capture molecules may then be grafted to the monolith pores.

  9. 同时蒸馏萃取/气质联用分析12种常见蜂花粉的挥发性成分%Analysisof Volatiles in Twelve Common Species of Bee Pollen by Gas Chromatography-Mass Spectrometry Combined with Simultaneous Distillation and Solvent Extraction

    Institute of Scientific and Technical Information of China (English)

    杨开; 邢辰; 胡君荣; 孙培龙; 叶兴乾

    2012-01-01

    目的:对市场上常见的12种蜂花粉品种进行挥发性成分分析与比较.方法:采用同时蒸馏萃取和气-质联用法测定蜂花粉中的挥发性成分.结果:共鉴定出74种挥发性化学成分,其中相对共有成分41种,相对特有成分33种,主要由烷烃类、烯炔烃类、醛酮类、醇类、脂类、芳香烃类、酚类和羧酸类等物质组成,且不同花粉品种中挥发性成分的组成与含量间差异较大,荞麦、葵花、荷花、玫瑰、五味子和蚕豆花粉中分别含有较显著的特征性成分.结论:蜂花粉的挥发性成分具有一定的品种特异性,且基本不含食用、日用香精中禁用物质和农药残留,食用安全性相对较高.%Objective: To determine and analyze the volatile compounds of twelve common species of bee pollen. Methods: The volatile compounds in twelve common species of bee pollen were analyzed and compared by GC-MS combined with simultaneous distillation and solvent extraction (SDE). Results: A total of 74 volatile components were determined in samples, including of 41 relatively common components and 33 relatively specific components. The analyzed compounds were mainly composed of alkanes, alkenes, alkynes, aldehydes, ketones, alcohols, lipids, benzenes, phenols and carboxylic acids, et al., and pollen samples had quite different profiles. Relevant specific ingredients were characterized in pollen of Fagopyrum esculentum L, Helumthus annuus L, Nelumbo nwifera Gaertn, Rosa rugosa, Schisandra chinensis, and Vicia faba L Conclusion; The volatile compounds tends to be species-specific. A relative food safety of bee pollen was indicated, as prohibited substances in daily used essences and pesticide residues were nearly inexistence in pollen volatiles.

  10. Twelve Months of Air Quality Monitoring at Ash Meadows National Wildlife Refuge, Southwestern Rural Nevada, U.S.A (EMSI April 2007)

    Energy Technology Data Exchange (ETDEWEB)

    Engelbrecht, Johann P; Shafer, David S; Campbell, Dave; Campbell, Scott; McCurdy, Greg; Kohl, Steven D; Nikolich, George; Sheetz, Larry

    2011-08-01

    The one year of air quality monitoring data collected at the Ash Meadows National Wildlife Refuge (NWR) was the final part of the air quality "Scoping Studies" for the Environmental Monitoring Systems Initiative (EMSI) in southern and central Nevada. The objective of monitoring at Ash Meadows was to examine aerosol and meteorological data, seasonal trends in aerosol and meteorological parameters as well as to examine evidence for long distance transport of some constituents. The 9,307 hectare refuge supports more than 50 springs and 24 endemic species, including the only population of the federally listed endangered Devil’s Hole pupfish (Cyprinodon diabolis) (U.S. Fish and Wildlife Service, 1990). Ash Meadows NWR is located in a Class II air quality area, and the aerosol measurements collected with this study are compared to those of Interagency Monitoring of Protected Visual Environments (IMPROVE) sites. Measurements taken at Ash Meadows NWR over a period of 12 months provide new baseline air quality and meteorological information for rural southwestern Nevada, specifically Nye County and the Amargosa Valley.

  11. A comparison of surgical outcomes of perineal urethrostomy plus penile resection and perineal urethrostomy in twelve calves with perineal or prescrotal urethral dilatation

    Directory of Open Access Journals (Sweden)

    M.A. Marzok

    2013-10-01

    Full Text Available The clinical diagnosis, ultrasonographic findings, surgical management, outcome, and survival rate of perineal or prescrotal urethral dilatation in 12 male calves are described. All calves were crossbred and intact males. The most noticeable clinical presentations were perineal (n= 10 or prescrotal (n= 2 swellings and micturition problems. The main ultrasonographic findings were oval shaped dilatation of the urethra in all animals with dimensions of 40-75 X 30-62 mm. The calves with perineal urethral dilatation were treated by perineal urethrostomy (n= 4 and partial penile transection including the dilated urethra and urethral fistulation (n= 6. Prescrotal urethral dilatations were treated by penile transection proximal to the dilatation site (n= 2. Cystitis and stricture of the urethra were recorded postoperatively for two of the calves that underwent perineal urethrostomy. Nine animals were slaughtered at normal body weight approximately 6-8 months after the surgical treatment. Three animals were slaughtered after approximately three to four months, two of them having gained insufficient body weight. Our study shows that ultrasonography is a useful tool for the diagnosis of urethral dilatation in bovine calves. Our study also shows that the partial penile transection may be a suitable and satisfactory choice of surgical treatment for correcting the urethral dilatation in bovine calves.

  12. Electric drive systems including smoothing capacitor cooling devices and systems

    Energy Technology Data Exchange (ETDEWEB)

    Dede, Ercan Mehmet; Zhou, Feng

    2017-02-28

    An electric drive system includes a smoothing capacitor including at least one terminal, a bus bar electrically coupled to the at least one terminal, a thermoelectric device including a first side and a second side positioned opposite the first side, where the first side is thermally coupled to at least one of the at least one terminal and the bus bar, and a cooling element thermally coupled to the second side of the thermoelectric device, where the cooling element dissipates heat from the thermoelectric device.

  13. Thermal swing reactor including a multi-flight auger

    Energy Technology Data Exchange (ETDEWEB)

    Ermanoski, Ivan

    2017-03-07

    A thermal swing reactor including a multi-flight auger and methods for solar thermochemical reactions are disclosed. The reactor includes a multi-flight auger having different helix portions having different pitch. Embodiments of reactors include at least two distinct reactor portions between which there is at least a pressure differential. In embodiments, reactive particles are exchanged between portions during a reaction cycle to thermally reduce the particles at first conditions and oxidize the particles at second conditions to produce chemical work from heat.

  14. High performance, durable polymers including poly(phenylene)

    Energy Technology Data Exchange (ETDEWEB)

    Fujimoto, Cy; Pratt, Harry; Anderson, Travis Mark

    2017-02-28

    The present invention relates to functionalized polymers including a poly(phenylene) structure. In some embodiments, the polymers and copolymers of the invention include a highly localized concentration of acidic moieties, which facilitate proton transport and conduction through networks formed from these polymers. In addition, the polymers can include functional moieties, such as electron-withdrawing moieties, to protect the polymeric backbone, thereby extending its durability. Such enhanced proton transport and durability can be beneficial for any high performance platform that employs proton exchange polymeric membranes, such as in fuel cells or flow batteries.

  15. In Vitro susceptibility of Gram-positive cocci isolated from skin and respiratory tract to azithromycin and twelve other antimicrobial agents

    Directory of Open Access Journals (Sweden)

    Caio M. F. Mendes

    2001-10-01

    advantages over erytromycin including improved oral bioavailability, longer half-life allowing once or twice daily administration, higher tissue concentrations and less gastrointestinal adverse effects.

  16. Twelve month follow-up report of the conference to promote international sales of US geothermal equipment (CORECT Project): Final report

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, D.N.

    1988-12-01

    The reverse trade mission ''Conference to Promote International Sales of US Geothermal Equipment'' was organized and managed by the Geothermal Resources Council (GRC) in collaboration with the California Energy Commission (CEC). The mission was held in late September/October of 1987 and was well received by the 23 participants from 18 different countries. Approximately $275,000 in immediate sales can be attributed directly to the program and the estimate of potential future sales runs as high as $4,765,000. It was felt by the attendees that the program was well organized and executed and that the caliber of persons invited to attend was optimum. All of the attendees stated that the function was very informative and beneficial and that they would recommend to others that they attend similar functions. In order to be really effective in exporting a company, a country must be highly visible to potential purchasers. Although this function lasted only two weeks it was considered as a prime first step in the development of a strong US geothermal technology export base program. As a part of the effort to maintain this presence the GRC recommends that this function be followed by other similar functions, courses, seminars, and specific field trips. In addition every effort should be made for US government and industry representatives to visit various countries as often as possible. The GRC is working toward developing an international information-dissemination program, which would include the development of courses for geothermal units in foreign countries.

  17. Phosphate concentration and arbuscular mycorrhizal colonisation influence the growth, yield and expression of twelve PHT1 family phosphate transporters in foxtail millet (Setaria italica.

    Directory of Open Access Journals (Sweden)

    S Antony Ceasar

    Full Text Available Phosphorus (P is an essential element which plays several key roles in all living organisms. Setaria italica (foxtail millet is a model species for panacoid grasses including several millet species widely grown in arid regions of Asia and Africa, and for the bioenergy crop switchgrass. The growth responses of S. italica to different levels of inorganic phosphate (Pi and to colonisation with the arbuscular mycorrhizal fungus Funneliformis mosseae (syn. Glomus mosseae were studied. Phosphate is taken up from the environment by the PHT1 family of plant phosphate transporters, which have been well characterized in several plant species. Bioinformatic analysis identified 12 members of the PHT1 gene family (SiPHT1;1-1;12 in S. italica, and RT and qPCR analysis showed that most of these transporters displayed specific expression patterns with respect to tissue, phosphate status and arbuscular mycorrhizal colonisation. SiPHT1;2 was found to be expressed in all tissues and in all growth conditions tested. In contrast, expression of SiPHT1;4 was induced in roots after 15 days growth in hydroponic medium of low Pi concentration. Expression of SiPHT1;8 and SiPHT1;9 in roots was selectively induced by colonisation with F. mosseae. SiPHT1;3 and SiPHT1;4 were found to be predominantly expressed in leaf and root tissues respectively. Several other transporters were expressed in shoots and leaves during growth in low Pi concentrations. This study will form the basis for the further characterization of these transporters, with the long term goal of improving the phosphate use efficiency of foxtail millet.

  18. Papilomatosis in dogs: literature review and study of twelve cases/ Papilomatose oral em cães: revisão da literatura e estudo de doze casos

    Directory of Open Access Journals (Sweden)

    Jane Megid

    2009-07-01

    Full Text Available Canine papillomatosis is an infectious viral disease characterized by oral, cutaneous or ocular papillomas, usually benign. The treatment is indicated in animals, with multiple tumors that produce pharyngeal obstruction, and problems of eating or for aesthetic reasons. Different treatment protocols have been proposed, including surgical excision, cryosurgery, electro surgery, autogenous or recombinant vaccines, imunomodulators drugs, systemic and intralesional chemotherapy. In this study were reviewed the more important aspects of canine oral papillomatosis. In the 12 studied animals, the papillomas were observed predominantly in mouth, gum and palate regions, in puppies until 12 months, presenting combined infection with ehrlichiosis. The treatment using Propionibacterium acnes and/or autogenous vaccine showed efficacy in eight dogs (66.7%.Papilomatose canina é uma enfermidade infecto-contagiosa viral caracterizada pela formação de papilomas orais, cutâneos ou oculares, geralmente benignos. O tratamento é indicado quando ocorre persistência dos tumores, lesões múltiplas causando obstrução faringeana, disfagia ou por razões estéticas. Diferentes protocolos de tratamento são descritos incluindo excisão cirúrgica, criocirurgia, eletrocirurgia, vacinas autógenas ou recombinantes, drogas imunomoduladoras, quimioterapia sistêmica ou intralesional. Foram revisados os principais aspectos clínico-epidemiológicos da papilomatose oral canina. Nos 12 animais estudados foram observados papilomas predominantemente em região de língua, gengiva e palato, com até 12 meses de idade e infecção combinada com erliquiose. O tratamento com Propionibacterium acnes e/ou vacina autócne surtiu efeito em oito animais (66,7%.

  19. Chronic Obstructive Pulmonary Disease (COPD) Includes: Chronic Bronchitis and Emphysema

    Science.gov (United States)

    ... Home Chronic Obstructive Pulmonary Disease (COPD) Includes: Chronic Bronchitis and Emphysema Recommend on Facebook Tweet Share Compartir ... U.S. Morbidity Number of adults with diagnosed chronic bronchitis in the past year: 9.3 million Percent ...

  20. Post-Polio Health International including International Ventilator Users Network

    Science.gov (United States)

    ... Place Explore the past, the present and help build a promising future for the world’s polio survivors. ... Polio Health International (PHI) Including International Ventilator Users Network 4207 Lindell Blvd., #110, Saint Louis, MO 63108- ...

  1. Should LSP Dictionaries also Include Professional Jargon and Slang?

    African Journals Online (AJOL)

    tional slang, as popular names for items of nomenclature, and also as trade names. ... and animals), in chemistry (the periodical system of elements, or the IUPAC .... includes new coinages from business journals and journalists' jargon which.

  2. General Information about Plasma Cell Neoplasms (Including Multiple Myeloma)

    Science.gov (United States)

    ... Cell Neoplasms Treatment Research Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment (PDQ®)–Patient Version General Information About Plasma ... the throat can make it hard to swallow. Multiple myeloma In multiple myeloma , abnormal plasma cells ( myeloma cells ) ...

  3. Stages of Plasma Cell Neoplasms (Including Multiple Myeloma)

    Science.gov (United States)

    ... Cell Neoplasms Treatment Research Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment (PDQ®)–Patient Version General Information About Plasma ... the throat can make it hard to swallow. Multiple myeloma In multiple myeloma , abnormal plasma cells ( myeloma cells ) ...

  4. Treatment Options for Plasma Cell Neoplasms (Including Multiple Myeloma)

    Science.gov (United States)

    ... Cell Neoplasms Treatment Research Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment (PDQ®)–Patient Version General Information About Plasma ... the throat can make it hard to swallow. Multiple myeloma In multiple myeloma , abnormal plasma cells ( myeloma cells ) ...

  5. Treatment Option Overview (Plasma Cell Neoplasms Including Multiple Myeloma)

    Science.gov (United States)

    ... Cell Neoplasms Treatment Research Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment (PDQ®)–Patient Version General Information About Plasma ... the throat can make it hard to swallow. Multiple myeloma In multiple myeloma , abnormal plasma cells ( myeloma cells ) ...

  6. When Should Zero Be Included on a Scale Showing Magnitude?

    Science.gov (United States)

    Kozak, Marcin

    2011-01-01

    This article addresses an important problem of graphing quantitative data: should one include zero on the scale showing magnitude? Based on a real time series example, the problem is discussed and some recommendations are proposed.

  7. Diabetes Nutrition: Including Sweets in Your Meal Plan

    Science.gov (United States)

    ... and stick to a healthy meal plan. Artificial sweeteners Examples of artificial sweeteners include: Acesulfame potassium (Sunett, ... can cause diarrhea in some people. Naturally derived sweeteners Naturally derived sweeteners, stevia (Truvia, PureVia) and agave ...

  8. Strategies to include sexual orientation and gender identity in health ...

    African Journals Online (AJOL)

    2015-05-04

    May 4, 2015 ... abuse, and are at higher risk for sexually transmitted diseases, including. HIV.[2] Because of mistrust in the ... [5,6] In countries where legislation penalises .... HIV/ STI risks. Discuss health prevention needs of transgender men.

  9. Good Security Practices for Electronic Commerce, Including Electronic Data Interchange

    Science.gov (United States)

    1993-12-01

    FROM - TO) xx-xx-2002 to xx-xx-2002 4. TITLE AND SUBTITLE Good Security Practices for Electronic Commerce , Including Electronic Data Interchange...Report 12/1/1993 4. TITLE AND SUBTITLE Good Security Practices for Electronic Commerce , Including Electronic Data Interchange 5. FUNDING NUMBERS 6...Maximum 200 Words) Electronic commerce (EC) is the use of documents in electronic form, rather than paper, for carrying out functions of business or

  10. Twelve-Month Prostate-Specific Antigen Values and Perineural Invasion as Strong Independent Prognostic Variables of Long-Term Biochemical Outcome After Prostate Seed Brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    Ding, William, E-mail: billyding888@gmail.com [Department of Radiation Oncology, California Pacific Medical Center, San Francisco, California (United States); Lee, John [Department of Radiation Oncology, California Pacific Medical Center, San Francisco, California (United States); Chamberlain, David [Department of Radiation Oncology, St. Mary' s Regional Medical Center, Reno, Nevada (United States); Cunningham, James [Carson Urology, Carson City, Nevada (United States); Yang Lixi [Department of Radiation Oncology, California Pacific Medical Center, San Francisco, California (United States); Tay, Jonathan [Department of Radiation Oncology, St. Mary' s Regional Medical Center, Reno, Nevada (United States)

    2012-11-15

    Purpose: To determine whether post-treatment prostate-specific antigen (ptPSA) values at 12 months and other clinical parameters predict long-term PSA relapse-free survival (PRFS) following prostate seed brachytherapy. Methods and Materials: Records of 204 hormone-naieve patients with localized adenocarcinoma of the prostate treated at St. Mary's Regional Medical Center in Reno, NV, and at Carson Tahoe Regional Medical Center in Carson City, NV, between 1998 and 2003, using I-125 or Pd-103 seed brachytherapy, were retrospectively analyzed. Treatment planning was done using a preplanned, modified peripheral loading technique. A total of 185 of 204 patients had PSA records at 12 months after implant. Variables included were age, initial pretreatment PSA, Gleason score, T stage, National Comprehensive Cancer Network (NCCN) risk group (RG), perineural invasion (PNI), external beam boost, dose, and ptPSA levels at 12 months with cutpoints at {<=}1, 1.01 to 2.00, 2.01 to 3.00, and >3.00 ng/ml. Results: Median follow-up was 80 months, and median age was 69 years. The numbers of patients stratified by NCCN low, intermediate, and high RG were 110:65:10, respectively. Monotherapy and boost prescription doses were 145 Gy and 110 Gy for I-125, and 125 Gy and 100 Gy for Pd-103 seeds, respectively. The median dose (D90) was 95.4% of the prescribed dose. The 5-year PRFS at the 12-months ptPSA levels of {<=}1, 1.01 to 2.00, 2.01 to 3.00, and >3.00 ng/ml were 98.5%, 85.7%, 61.5%, and 22.2%, respectively. The 10-year PRFS at the 12-months ptPSA levels of {<=}1 and 1.01 to 2.00 ng/ml were 90.5% and 85.7%, respectively. In multivariate analysis, both ptPSA and PNI were significant independent predictors of PRFS. Hazard ratios (HR) for ptPSA levels at {<=}1, 1.01 to 2.00, 2.01 to 3.00, and >3.00 ng/ml at 12 months were 1, 4.96, 27.57, and 65.10, respectively. PNI had an HR of 6.1 (p = 0.009). Conclusions: Presence of PNI and ptPSA values at 12 months are strong prognostic

  11. The effects of twelve weeks of bed rest on bone histology, biochemical markers of bone turnover, and calcium homeostasis in eleven normal subjects

    Science.gov (United States)

    Zerwekh, J. E.; Ruml, L. A.; Gottschalk, F.; Pak, C. Y.; Blomqvist, C. G. (Principal Investigator)

    1998-01-01

    This study was undertaken to examine the effects of 12 weeks of skeletal unloading on parameters of calcium homeostasis, calcitropic hormones, bone histology, and biochemical markers of bone turnover in 11 normal subjects (9 men, 2 women; 34 +/- 11 years of age). Following an ambulatory control evaluation, all subjects underwent 12 weeks of bed rest. An additional metabolic evaluation was performed after 12 days of reambulation. Bone mineral density declined at the spine (-2.9%, p = 0.092) and at the hip (-3.8%, p = 0.002 for the trochanter). Bed rest prompted a rapid, sustained, significant increase in urinary calcium and phosphorus as well as a significant increase in serum calcium. Urinary calcium increased from a pre-bed rest value of 5.3 mmol/day to values as high as 73 mmol/day during bed rest. Immunoreactive parathyroid hormone and serum 1,25-dihydroxyvitamin D declined significantly during bed rest, although the mean values remained within normal limits. Significant changes in bone histology included a suppression of osteoblastic surface for cancellous bone (3.1 +/- 1.3% to 1.9 +/- 1.5%, p = 0.0142) and increased bone resorption for both cancellous and cortical bone. Cortical eroded surface increased from 3.5 +/- 1.1% to 7.3 +/- 4.0% (p = 0.018) as did active osteoclastic surface (0.2 +/- 0.3% to 0.7 +/- 0.7%, p = 0.021). Cancellous eroded surface increased from 2.1 +/- 1.1% to 4.7 +/- 2.2% (p = 0.002), while mean active osteoclastic surface doubled (0.2 +/- 0.2% to 0.4 +/- 0.3%, p = 0.020). Serum biochemical markers of bone formation (osteocalcin, bone-specific alkaline phosphatase, and type I procollagen extension peptide) did not change significantly during bed rest. Urinary biochemical markers of bone resorption (hydroxyproline, deoxypyridinoline, and N-telopeptide of type I collagen) as well as a serum marker of bone resorption (type I collagen carboxytelopeptide) all demonstrated significant increases during bed rest which declined toward normal

  12. A sonic boom propagation model including mean flow atmospheric effects

    Science.gov (United States)

    Salamone, Joe; Sparrow, Victor W.

    2012-09-01

    This paper presents a time domain formulation of nonlinear lossy propagation in onedimension that also includes the effects of non-collinear mean flow in the acoustic medium. The model equation utilized is an augmented Burgers equation that includes the effects of nonlinearity, geometric spreading, atmospheric stratification, and also absorption and dispersion due to thermoviscous and molecular relaxation effects. All elements of the propagation are implemented in the time domain and the effects of non-collinear mean flow are accounted for in each term of the model equation. Previous authors have presented methods limited to showing the effects of wind on ray tracing and/or using an effective speed of sound in their model equation. The present work includes the effects of mean flow for all terms included in the augmented Burgers equation with all of the calculations performed in the time-domain. The capability to include the effects of mean flow in the acoustic medium allows one to make predictions more representative of real-world atmospheric conditions. Examples are presented for nonlinear propagation of N-waves and shaped sonic booms. [Work supported by Gulfstream Aerospace Corporation.

  13. A Framework for Including Family Health Spillovers in Economic Evaluation.

    Science.gov (United States)

    Al-Janabi, Hareth; van Exel, Job; Brouwer, Werner; Coast, Joanna

    2016-02-01

    Health care interventions may affect the health of patients' family networks. It has been suggested that these "health spillovers" should be included in economic evaluation, but there is not a systematic method for doing this. In this article, we develop a framework for including health spillovers in economic evaluation. We focus on extra-welfarist economic evaluations where the objective is to maximize health benefits from a health care budget (the "health care perspective"). Our framework involves adapting the conventional cost-effectiveness decision rule to include 2 multiplier effects to internalize the spillover effects. These multiplier effects express the ratio of total health effects (for patients and their family networks) to patient health effects. One multiplier effect is specified for health benefit generated from providing a new intervention, one for health benefit displaced by funding this intervention. We show that using multiplier effects to internalize health spillovers could change the optimal funding decisions and generate additional health benefits to society.

  14. Ceramic substrate including thin film multilayer surface conductor

    Science.gov (United States)

    Wolf, Joseph Ambrose; Peterson, Kenneth A.

    2017-05-09

    A ceramic substrate comprises a plurality of ceramic sheets, a plurality of inner conductive layers, a plurality of vias, and an upper conductive layer. The ceramic sheets are stacked one on top of another and include a top ceramic sheet. The inner conductive layers include electrically conductive material that forms electrically conductive features on an upper surface of each ceramic sheet excluding the top ceramic sheet. The vias are formed in each of the ceramic sheets with each via being filled with electrically conductive material. The upper conductive layer includes electrically conductive material that forms electrically conductive features on an upper surface of the top ceramic sheet. The upper conductive layer is constructed from a stack of four sublayers. A first sublayer is formed from titanium. A second sublayer is formed from copper. A third sublayer is formed from platinum. A fourth sublayer is formed from gold.

  15. Classical mechanics including an introduction to the theory of elasticity

    CERN Document Server

    Hentschke, Reinhard

    2017-01-01

    This textbook teaches classical mechanics as one of the foundations of physics. It describes the mechanical stability and motion in physical systems ranging from the molecular to the galactic scale. Aside from the standard topics of mechanics in the physics curriculum, this book includes an introduction to the theory of elasticity and its use in selected modern engineering applications, e.g. dynamic mechanical analysis of viscoelastic materials. The text also covers many aspects of numerical mechanics, ranging from the solution of ordinary differential equations, including molecular dynamics simulation of many particle systems, to the finite element method. Attendant Mathematica programs or parts thereof are provided in conjunction with selected examples. Numerous links allow the reader to connect to related subjects and research topics. Among others this includes statistical mechanics (separate chapter), quantum mechanics, space flight, galactic dynamics, friction, and vibration spectroscopy. An introductory...

  16. Internet addiction neuroscientific approaches and therapeutical implications including smartphone addiction

    CERN Document Server

    Reuter, Martin

    2017-01-01

    The second edition of this successful book provides further and in-depth insight into theoretical models dealing with Internet addiction, as well as includes new therapeutical approaches. The editors also broach the emerging topic of smartphone addiction. This book combines a scholarly introduction with state-of-the-art research in the characterization of Internet addiction. It is intended for a broad audience including scientists, students and practitioners. The first part of the book contains an introduction to Internet addiction and their pathogenesis. The second part of the book is dedicated to an in-depth review of neuroscientific findings which cover studies using a variety of biological techniques including brain imaging and molecular genetics. The third part of the book focuses on therapeutic interventions for Internet addiction. The fourth part of the present book is an extension to the first edition and deals with a new emerging potential disorder related to Internet addiction – smartphone addicti...

  17. Including patients’ perspectives in patient information leaflets: A polyocular approach

    DEFF Research Database (Denmark)

    Fage-Butler, Antoinette Mary

    2013-01-01

    asymmetries. The paper contributes theoretically in its innovative use of perspectivist theory in relation to text, and in identifying that the insights of polyocularity could valuably inform a new health communication paradigm, as current health communication paradigms do not fully recognize patients......Existing research reveals that patients’ perspectives are missing from mandatory patient information leaflets (PILs). At the same time, there is overwhelming consensus that they should be included in this genre, and a corresponding need for potential approaches to tackle this problem. This paper......’ perspectives. Apart from its theoretical contributions, the paper includes guidelines to support the production of PILs where patients’ perspectives are included. The guidelines are informed by practices that have characterised previous polyocular communication events, as well as research into how to maximize...

  18. Including information technology project management in the nursing informatics curriculum.

    Science.gov (United States)

    Sockolow, Paulina; Bowles, Kathryn H

    2008-01-01

    Project management is a critical skill for nurse informaticists who are in prominent roles developing and implementing clinical information systems. It should be included in the nursing informatics curriculum, as evidenced by its inclusion in informatics competencies and surveys of important skills for informaticists. The University of Pennsylvania School of Nursing includes project management in two of the four courses in the master's level informatics minor. Course content includes the phases of the project management process; the iterative unified process methodology; and related systems analysis and project management skills. During the introductory course, students learn about the project plan, requirements development, project feasibility, and executive summary documents. In the capstone course, students apply the system development life cycle and project management skills during precepted informatics projects. During this in situ experience, students learn, the preceptors benefit, and the institution better prepares its students for the real world.

  19. Pediatric deformity treatment update, including 3D correction concepts%Pediatric deformity treatment update,including 3D correction concepts

    Institute of Scientific and Technical Information of China (English)

    Randal R. Betz; Patrick J. Cahill; Joshua M. Pahys; Amer F. Samdani

    2011-01-01

    The purpose of this article is to highlight some of the new developments in the treatment of adolescent idiopathic scoliosis,including 3D correction of deformity,posterior and minimally invasive surgery,and fusionless strategies.

  20. Solar Energy Education. Renewable energy: a background text. [Includes glossary

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    Some of the most common forms of renewable energy are presented in this textbook for students. The topics include solar energy, wind power hydroelectric power, biomass ocean thermal energy, and tidal and geothermal energy. The main emphasis of the text is on the sun and the solar energy that it yields. Discussions on the sun's composition and the relationship between the earth, sun and atmosphere are provided. Insolation, active and passive solar systems, and solar collectors are the subtopics included under solar energy. (BCS)

  1. Seismic Response of Wind Turbines: Time Domain Simulations Including SSI

    OpenAIRE

    Amdal, Åse Marit Wist

    2014-01-01

    In this study, a numerical model of a 5MW offshore wind turbine on a monopile foundation was created in order to calculate the dynamic response of the structure including soil-structure interaction. The main focus was to develop a reliable numerical model of the coupled system - including the tower, monopile foundation and the surrounding soil. The wind turbine was subjected to earthquake load in the time-domain. The global response of the wind turbine was compared for the two prevalent meth...

  2. Methods of producing adsorption media including a metal oxide

    Science.gov (United States)

    Mann, Nicholas R; Tranter, Troy J

    2014-03-04

    Methods of producing a metal oxide are disclosed. The method comprises dissolving a metal salt in a reaction solvent to form a metal salt/reaction solvent solution. The metal salt is converted to a metal oxide and a caustic solution is added to the metal oxide/reaction solvent solution to adjust the pH of the metal oxide/reaction solvent solution to less than approximately 7.0. The metal oxide is precipitated and recovered. A method of producing adsorption media including the metal oxide is also disclosed, as is a precursor of an active component including particles of a metal oxide.

  3. Tunable cavity resonator including a plurality of MEMS beams

    Energy Technology Data Exchange (ETDEWEB)

    Peroulis, Dimitrios; Fruehling, Adam; Small, Joshua Azariah; Liu, Xiaoguang; Irshad, Wasim; Arif, Muhammad Shoaib

    2015-10-20

    A tunable cavity resonator includes a substrate, a cap structure, and a tuning assembly. The cap structure extends from the substrate, and at least one of the substrate and the cap structure defines a resonator cavity. The tuning assembly is positioned at least partially within the resonator cavity. The tuning assembly includes a plurality of fixed-fixed MEMS beams configured for controllable movement relative to the substrate between an activated position and a deactivated position in order to tune a resonant frequency of the tunable cavity resonator.

  4. Six-dimensional beam-beam kick including coupled motion

    Directory of Open Access Journals (Sweden)

    L. H. A. Leunissen

    2000-12-01

    Full Text Available The six-dimensional beam-beam interaction as developed in 1992 by Hirata, Moshammer, and Ruggiero has been extended to include linear coupled motion and an arbitrary crossing plane. The technique of symplectic mapping in the six-dimensional phase space, called synchrobeam mapping, is applied to investigate the beam-beam kick within a solenoid. A linear beam-beam model including coupling is discussed in detail, also in the framework of a six-dimensional symplectic dispersion formalism.

  5. The Future of Constitutionally Required Lesser Included Offenses

    Directory of Open Access Journals (Sweden)

    Michael H. Hoffheimer

    2006-04-01

    Full Text Available For over a generation courts have recognized that failing to instruct juries on lesser included offenses results in wrongful convictions. In Beck v. Alabama, the Supreme Court held that in capital cases juries must be instructed on the option of returning convictions of non-capital lesser included offenses. The Court explained that this right prevents juries from being forced to make all-or-nothing choices between guilt and innocence in cases where serious crimes have been committed and pressures to convict of some crime are great.

  6. Should Listening and Speaking be included in a Language Test?

    Institute of Scientific and Technical Information of China (English)

    李宗文

    2013-01-01

      Language test is widely used in our daily life for various purposes, while a lot of language tests fail to include listening or speaking for one reason or another. The question that whether this type of test is still valid enough to serve test purposes and have a positive washback for English learning has come up.

  7. Synaptic channel model including effects of spike width variation

    OpenAIRE

    2015-01-01

    Synaptic Channel Model Including Effects of Spike Width Variation Hamideh Ramezani Next-generation and Wireless Communications Laboratory (NWCL) Department of Electrical and Electronics Engineering Koc University, Istanbul, Turkey Ozgur B. Akan Next-generation and Wireless Communications Laboratory (NWCL) Department of Electrical and Electronics Engineering Koc University, Istanbul, Turkey ABSTRACT An accu...

  8. Truck Drivers And Risk Of STDs Including HIV

    Directory of Open Access Journals (Sweden)

    Bansal R.K

    1995-01-01

    Full Text Available Research Question: Whether long distance truck drivers are at a higher risk of contracting and transmitting STDs including HIV? Objectives: i To study the degree of knowledge of HIV and AIDS among long- distance truck drivers. ii Assess their sexual behaviour including condom use. iii Explore their prevailing social influences and substance abuse patterns. iv Explore their treatment seeking bahaviour as regards STDs. v Deduce their risk of contracting and transmitting STDs including HIV. Study Design: Cross- sectional interview. Setting: Transport Nagar, Indore (M.P Participants: 210 senior drivers (First drivers and 210 junior drivers (Second drivers. Study Variables: Extra-Marital sexual intercourse, condom usage, past and present history of STDs, treatment and counseling, substance abuse, social â€" cultural milieu. Outcome Variables: Risk of contraction of STDs. Statistical Analysis: Univariate analysis. Results: 94% of the drivers were totally ignorant about AIDS. 82.9% and 43.8 % of the senior and junior drivers had a history of extra- marital sex and of these only 2 regularly used condoms. 13.8% and 3.3 % of the senior and junior drivers had a past or present history suggestive of STD infection. Alcohol and Opium were regularly used by them. Conclusion: The studied drivers are at a high risk of contracting and transmitting STDs including HIV.

  9. A Reactive Behavior Agent: Including Emotions into a Video Game

    Directory of Open Access Journals (Sweden)

    A. L. Laureano-Cruces

    2012-10-01

    Full Text Available Why we have emotions and how they influence human behavior are two questions we constantly ask ourselves.According to researchers in the field, there are two kinds of information that the person receives to make a decision.This information is integrated to generate a whole. One comes from ourselves it is proprioceptive and refers toemotions; the other one is external, it comes from the environment. Thus, emotions are immersed in different areas ofa person’s life, including social, functional, and cognitive aspects. It has an important role in the decision-makingprocess. It is on this last point that this paper focuses its approach, which consists of including a cognitive structure ofemotions in a reactive behavior in order to enrich behavior, including the information generated through internalevaluation of the external physical stimuli. Our work is based on the OCC theory (named after the name of its authors:Ortony, Collins and Clore. This theory proposes that a decision-making process is affected through differentperspectives: a goals and events, b agents and their actions, and c objects and their capacity for attraction. Thecase study is situated within a scenario that represents an approach that seeks to include a module of emotions withinthe design of the architecture of a videogame.

  10. The Subjectivities of "Included" Students with Disabilities in Schools

    Science.gov (United States)

    Whitburn, Ben

    2017-01-01

    The contextual precept of this paper is to re-theorise inclusive education beyond technical rational solutions to the "problem" of disability. Drawing on Foucauldian and critical disability theories, I make the case for the analysis of inclusive schooling through the lens of students' "included" subjectivities--notwithstanding…

  11. Restructuring the Public School Curriculum To Include Parenting Education Classes.

    Science.gov (United States)

    Tyree, Carolyn L.; And Others

    Although the current educational climate stresses a back-to-basics approach, there is nonetheless overwhelming evidence of a need for an appropriately structured parenting education program in the public school curriculum. Reasons for this need include the large number of teenage pregnancies and abortions. These lead teens to miss high school…

  12. Understanding heat transfer in 2D channel flows including recirculation

    NARCIS (Netherlands)

    Dirkse, M.H.; Loon, van W.K.P.; Stigter, J.D.; Bot, G.P.A.

    2007-01-01

    Inviscid, irrotational two-dimensional flows can be modelled using the Schwarz¿Christoffel integral. Although bounded flows including boundary layer separation and recirculation are not irrotational, a model is presented that uses the Schwarz¿Christoffel integral to model these flows. The model sepa

  13. Interviewing Objects: Including Educational Technologies as Qualitative Research Participants

    Science.gov (United States)

    Adams, Catherine A.; Thompson, Terrie Lynn

    2011-01-01

    This article argues the importance of including significant technologies-in-use as key qualitative research participants when studying today's digitally enhanced learning environments. We gather a set of eight heuristics to assist qualitative researchers in "interviewing" technologies-in-use (or other relevant objects), drawing on concrete…

  14. Mixture including hydrogen and hydrocarbon having pressure-temperature stability

    Science.gov (United States)

    Mao, Wendy L. (Inventor); Mao, Ho-Kwang (Inventor)

    2009-01-01

    The invention relates to a method of storing hydrogen that employs a mixture of hydrogen and a hydrocarbon that can both be used as fuel. In one embodiment, the method involves maintaining a mixture including hydrogen and a hydrocarbon in the solid state at ambient pressure and a temperature in excess of about 10 K.

  15. Unsteady panel method for complex configurations including wake modeling

    CSIR Research Space (South Africa)

    Van Zyl, Lourens H

    2008-01-01

    Full Text Available implementations of the DLM are however not very versatile in terms of geometries that can be modeled. The ZONA6 code offers a versatile surface panel body model including a separated wake model, but uses a pressure panel method for lifting surfaces. This paper...

  16. Visual Impairments, "Including Blindness." NICHCY Disability Fact Sheet #13

    Science.gov (United States)

    National Dissemination Center for Children with Disabilities, 2012

    2012-01-01

    Vision is one of the five senses. Being able to see gives tremendous access to learning about the world around--people's faces and the subtleties of expression, what different things look like and how big they are, and the physical environments, including approaching hazards. When a child has a visual impairment, it is cause for immediate…

  17. Interviewing Objects: Including Educational Technologies as Qualitative Research Participants

    Science.gov (United States)

    Adams, Catherine A.; Thompson, Terrie Lynn

    2011-01-01

    This article argues the importance of including significant technologies-in-use as key qualitative research participants when studying today's digitally enhanced learning environments. We gather a set of eight heuristics to assist qualitative researchers in "interviewing" technologies-in-use (or other relevant objects), drawing on concrete…

  18. Modeling Electric Double-Layers Including Chemical Reaction Effects

    DEFF Research Database (Denmark)

    Paz-Garcia, Juan Manuel; Johannesson, Björn; Ottosen, Lisbeth M.

    2014-01-01

    A physicochemical and numerical model for the transient formation of an electric double-layer between an electrolyte and a chemically-active flat surface is presented, based on a finite elements integration of the nonlinear Nernst-Planck-Poisson model including chemical reactions. The model works...

  19. Including patients’ perspectives in patient information leaflets: A polyocular approach

    DEFF Research Database (Denmark)

    Fage-Butler, Antoinette Mary

    2013-01-01

    Existing research reveals that patients’ perspectives are missing from mandatory patient information leaflets (PILs). At the same time, there is overwhelming consensus that they should be included in this genre, and a corresponding need for potential approaches to tackle this problem. This paper...

  20. 10 CFR 905.11 - What must an IRP include?

    Science.gov (United States)

    2010-01-01

    ... data (such as service area, geographical characteristics, customer mix, historical loads, projected... consumer. (iii) Considerations that may be used to develop potential options include cost, market potential... customer must make the load forecasting data available to Western upon request. (6) Measurement...

  1. Assessing the Doctoral Thesis When It Includes Published Work

    Science.gov (United States)

    Sharmini, Sharon; Spronken-Smith, Rachel; Golding, Clinton; Harland, Tony

    2015-01-01

    In this article we explore how examiners assess a thesis that includes published work. An online survey was used to gather data on approaches to assessing publication-based theses (PBTs). The respondents were 62 supervisors who had experience examining PBTs across a range of disciplines at a research-intensive university in New Zealand. Nearly…

  2. 20 CFR 220.114 - Evaluation of symptoms, including pain.

    Science.gov (United States)

    2010-04-01

    ... a determination as to the intensity, persistence, or functionally limiting effects of the claimant's... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evaluation of symptoms, including pain. 220.114 Section 220.114 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE...

  3. 34 CFR 429.20 - What must an application include?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What must an application include? 429.20 Section 429.20 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION BILINGUAL VOCATIONAL MATERIALS, METHODS, AND TECHNIQUES...

  4. 14 CFR 25.1181 - Designated fire zones; regions included.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Designated fire zones; regions included. 25.1181 Section 25.1181 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... accessory section; (4) Any auxiliary power unit compartment; (5) Any fuel-burning heater and other...

  5. 14 CFR 29.1181 - Designated fire zones: regions included.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Designated fire zones: regions included. 29.1181 Section 29.1181 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF...; (5) Any fuel-burning heater and other combustion equipment installation described in § 29.859; (6...

  6. 14 CFR 23.1181 - Designated fire zones; regions included.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Designated fire zones; regions included. 23.1181 Section 23.1181 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF..., turbine, and tailpipe sections. (c) Any auxiliary power unit compartment; and (d) Any fuel-burning heater...

  7. The International Project 1992 Update Including "Microfilming Projects Abroad."

    Science.gov (United States)

    Rutimann, Hans

    1993-01-01

    Describes microfilming projects in 30 countries collected from questionnaire responses. Additional topics discussed include cooperative programs for preservation and access; an overview of national programs; mass deacidification; new technologies, such as digital preservation; microfilming projects abroad; and future priorities. (Contains 10…

  8. Thick Plate Homogenization of Sandwich Panels Including Folded Cellular Cores

    OpenAIRE

    LEBEE, Arthur; Sab, Karam

    2011-01-01

    In the present work, we provide the Bending-Gradient homogenization scheme and apply it to a sandwich panel including the chevron pattern. It turns out that the shear forces stiffness of the sandwich panel is strongly influenced by a skin distortion phenomenon which cannot be neglected in conventional design.

  9. The Instructional Improvement Questionnaire [Including Supporting and Technical Data].

    Science.gov (United States)

    Pohlmann, John T.; Elmore, Patricia B.

    The Instructional Improvement Questionnaire (IIQ) is a student rating form designed to provide evaluative feedback to instructors about their teaching. The IIQ was first developed at Southern Illinois University at Carbondale in 1969 and revised in 1972. The documents included here describe the development of the IIQ and research associated with…

  10. 30 CFR 250.211 - What must the EP include?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must the EP include? 250.211 Section 250.211 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND... exploration drilling, well test flaring, installing a well protection structure, and temporary...

  11. Smart Antenna Skins, including Conformal Array, MMICs and Applications

    NARCIS (Netherlands)

    Bogaart, F.L.M. van den

    2000-01-01

    Low-cost technologies are presented for future space-borne and airborne SAR systems. These technologies include state-of-the art highly integrated circuits to miniaturise front-end, solutions to lower-cost interconnection technologies, new beamforming aspects and new architectures. The MMICs address

  12. Including History in the Study of Psychological and Political Power

    Science.gov (United States)

    Reich, Stephanie M.; Pinkard, Tracy; Davidson, Heather

    2008-01-01

    Isaac Prilleltensky's (2003) concept of psychopolitical validity stresses the need to consider both the political and the psychological nature of power in the study of wellness, oppression, and liberation. The authors advocate that psychopolitical validity would be strengthened if it included an explicit appreciation of historical context. The…

  13. Smart Antenna Skins, including Conformal Array, MMICs and Applications

    NARCIS (Netherlands)

    Bogaart, F.L.M. van den

    2000-01-01

    Low-cost technologies are presented for future space-borne and airborne SAR systems. These technologies include state-of-the art highly integrated circuits to miniaturise front-end, solutions to lower-cost interconnection technologies, new beamforming aspects and new architectures. The MMICs address

  14. Including History in the Study of Psychological and Political Power

    Science.gov (United States)

    Reich, Stephanie M.; Pinkard, Tracy; Davidson, Heather

    2008-01-01

    Isaac Prilleltensky's (2003) concept of psychopolitical validity stresses the need to consider both the political and the psychological nature of power in the study of wellness, oppression, and liberation. The authors advocate that psychopolitical validity would be strengthened if it included an explicit appreciation of historical context. The…

  15. /facet: A Generic Facet Browser Including Temporal and Spatial Visualization

    NARCIS (Netherlands)

    Hildebrand, M.

    2007-01-01

    A generic facet browser including temporal and spatial visualization. The existing MultimediaN Eculture demo is updated in two ways: improved visualization of the semantic timeline and added a natural language sentence generator for cluster headers. Relation search interface is also implemente

  16. 31 CFR 306.87 - Partnerships (including nominee partnerships).

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Partnerships (including nominee partnerships). 306.87 Section 306.87 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT GENERAL...

  17. Computer aided design of reentrant coaxial filters including coaxial excitation

    NARCIS (Netherlands)

    Boria, V.; Gerini, G.; Guglielmi, M.

    1999-01-01

    An advanced EM based CAD tool is used for the detailed characterisation of a family of reentrant coaxial waveguide filters. The EM analysis includes the effects of tuning screws and of the input/output coaxial excitation. The software is essentially used as an efficient replacement for the tradition

  18. Methodological challenges when doing research that includes ethnic minorities

    DEFF Research Database (Denmark)

    Morville, Anne-Le; Erlandsson, Lena-Karin

    2016-01-01

    minorities are included. Method: A thorough literature search yielded 21 articles obtained from the scientific databases PubMed, Cinahl, Web of Science and PsychInfo. Analysis followed Arksey and O’Malley’s framework for scoping reviews, applying content analysis. Results: The results showed methodological...

  19. Including expectant fathers in antenatal education programmes in Istanbul, Turkey.

    Science.gov (United States)

    Turan, J M; Nalbant, H; Bulut, A; Sahip, Y

    2001-11-01

    In this article we present the results of three studies investigating methods for including men in antenatal education in Istanbul, Turkey. Participants were first-time expectant parents living in low and middle-income areas. After a formative study on the roles of various family members in health during the period surrounding a first birth, an antenatal-clinic-based education programme for women and for couples was carried out as a randomised, controlled study. Based on the results, separate community-based antenatal education programmes for expectant mothers and expectant fathers were tested. There was demand among many pregnant women and some of their husbands for including expectant fathers in antenatal education. In the short term, these programmes seemed to have positive effects on women and men's reproductive health knowledge, attitudes and behaviours. In the clinic-based programme the positive effects of including men were mainly in the area of post-partum family planning, while in the community-based programme positive effects among men were also seen in the areas of infant health, infant feeding and spousal communication and support. Free antenatal education should be made available to all expectant mothers and when possible, men should be included, either together with their wives or in a culture such as that of Turkey, in separate groups.

  20. Energy storage device including a redox-enhanced electrolyte

    Energy Technology Data Exchange (ETDEWEB)

    Stucky, Galen; Evanko, Brian; Parker, Nicholas; Vonlanthen, David; Auston, David; Boettcher, Shannon; Chun, Sang-Eun; Ji, Xiulei; Wang, Bao; Wang, Xingfeng; Chandrabose, Raghu Subash

    2017-08-08

    An electrical double layer capacitor (EDLC) energy storage device is provided that includes at least two electrodes and a redox-enhanced electrolyte including two redox couples such that there is a different one of the redox couples for each of the electrodes. When charged, the charge is stored in Faradaic reactions with the at least two redox couples in the electrolyte and in a double-layer capacitance of a porous carbon material that comprises at least one of the electrodes, and a self-discharge of the energy storage device is mitigated by at least one of electrostatic attraction, adsorption, physisorption, and chemisorption of a redox couple onto the porous carbon material.

  1. Maximum-entropy closure of hydrodynamic moment hierarchies including correlations.

    Science.gov (United States)

    Hughes, Keith H; Burghardt, Irene

    2012-06-07

    Generalized hydrodynamic moment hierarchies are derived which explicitly include nonequilibrium two-particle and higher-order correlations. The approach is adapted to strongly correlated media and nonequilibrium processes on short time scales which necessitate an explicit treatment of time-evolving correlations. Closure conditions for the extended moment hierarchies are formulated by a maximum-entropy approach, generalizing related closure procedures for kinetic equations. A self-consistent set of nonperturbative dynamical equations are thus obtained for a chosen set of single-particle and two-particle (and possibly higher-order) moments. Analytical results are derived for generalized Gaussian closures including the dynamic pair distribution function and a two-particle correction to the current density. The maximum-entropy closure conditions are found to involve the Kirkwood superposition approximation.

  2. Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial Function

    Directory of Open Access Journals (Sweden)

    Simon N. Dankel

    2011-01-01

    Full Text Available A better understanding of the molecular links between obesity and disease is potentially of great benefit for society. In this paper we discuss proposed mechanisms whereby bariatric surgery improves metabolic health, including acute effects on glucose metabolism and long-term effects on metabolic tissues (adipose tissue, skeletal muscle, and liver and mitochondrial function. More short-term randomized controlled trials should be performed that include simultaneous measurement of metabolic parameters in different tissues, such as tissue gene expression, protein profile, and lipid content. By directly comparing different surgical procedures using a wider array of metabolic parameters, one may further unravel the mechanisms of aberrant metabolic regulation in obesity and related disorders.

  3. Including investment risk in large-scale power market models

    DEFF Research Database (Denmark)

    Lemming, Jørgen Kjærgaard; Meibom, P.

    2003-01-01

    can be included in large-scale partial equilibrium models of the power market. The analyses are divided into a part about risk measures appropriate for power market investors and a more technical part about the combination of a risk-adjustment model and a partial-equilibrium model. To illustrate......Long-term energy market models can be used to examine investments in production technologies, however, with market liberalisation it is crucial that such models include investment risks and investor behaviour. This paper analyses how the effect of investment risk on production technology selection...... the analyses quantitatively, a framework based on an iterative interaction between the equilibrium model and a separate risk-adjustment module was constructed. To illustrate the features of the proposed modelling approach we examined how uncertainty in demand and variable costs affects the optimal choice...

  4. Progressive IRP Models for Power Resources Including EPP

    Directory of Open Access Journals (Sweden)

    Yiping Zhu

    2017-01-01

    Full Text Available In the view of optimizing regional power supply and demand, the paper makes effective planning scheduling of supply and demand side resources including energy efficiency power plant (EPP, to achieve the target of benefit, cost, and environmental constraints. In order to highlight the characteristics of different supply and demand resources in economic, environmental, and carbon constraints, three planning models with progressive constraints are constructed. Results of three models by the same example show that the best solutions to different models are different. The planning model including EPP has obvious advantages considering pollutant and carbon emission constraints, which confirms the advantages of low cost and emissions of EPP. The construction of progressive IRP models for power resources considering EPP has a certain reference value for guiding the planning and layout of EPP within other power resources and achieving cost and environmental objectives.

  5. XFEL OSCILLATOR SIMULATION INCLUDING ANGLE-DEPENDENT CRYSTAL REFLECTIVITY

    Energy Technology Data Exchange (ETDEWEB)

    Fawley, William; Lindberg, Ryan; Kim, K-J; Shvyd' ko, Yuri

    2010-08-23

    The oscillator package within the GINGER FEL simulation code has now been extended to include angle-dependent reflectivity properties of Bragg crystals. Previously, the package was modified to include frequencydependent reflectivity in order to model x-ray FEL oscillators from start-up from shot noise through to saturation. We present a summary of the algorithms used for modeling the crystal reflectivity and radiation propagation outside the undulator, discussing various numerical issues relevant to the domain of high Fresnel number and efficient Hankel transforms. We give some sample XFEL-O simulation results obtained with the angle-dependent reflectivity model, with particular attention directed to the longitudinal and transverse coherence of the radiation output.

  6. The Physics of Semiconductors An Introduction Including Devices and Nanophysics

    CERN Document Server

    Grundmann, Marius

    2006-01-01

    The Physics of Semiconductors provides material for a comprehensive upper-level-undergrauate and graduate course on the subject, guiding readers to the point where they can choose a special topic and begin supervised research. The textbook provides a balance between essential aspects of solid-state and semiconductor physics, on the one hand, and the principles of various semiconductor devices and their applications in electronic and photonic devices, on the other. It highlights many practical aspects of semiconductors such as alloys, strain, heterostructures, nanostructures, that are necessary in modern semiconductor research but typically omitted in textbooks. For the interested reader some additional advanced topics are included, such as Bragg mirrors, resonators, polarized and magnetic semiconductors are included. Also supplied are explicit formulas for many results, to support better understanding. The Physics of Semiconductors requires little or no prior knowledge of solid-state physics and evolved from ...

  7. Improving the strength of amalgams by including steel fibers

    Energy Technology Data Exchange (ETDEWEB)

    Cochran, Calvin T. [Hendrix College, Conway, AR 72032 (United States); Van Hoose, James R. [Siemens, Orlando, FL 32826 (United States); McGill, Preston B. [Marshall Space Flight Center, EM20, Huntsville, AL 35812 (United States); Grugel, Richard N., E-mail: richard.n.grugel@nasa.gov [Marshall Space Flight Center, EM30, Huntsville, AL 35812 (United States)

    2012-05-30

    Highlights: Black-Right-Pointing-Pointer A room temperature liquid Ga-In alloy was successfully substituted for mercury. Black-Right-Pointing-Pointer Physically sound amalgams with included steel fibers can be made. Black-Right-Pointing-Pointer A small volume fraction inclusion of fibers increased strength by {approx}20%. - Abstract: Mercury amalgams, due to their material properties, are widely and successfully used in dental practice. They are, however, also well recognized as having poor tensile strength. With the possibility of expanding amalgam applications it is demonstrated that tensile strength can be increased some 20% by including a small amount of steel fibers. Furthermore, it is shown that mercury can be replaced with a room temperature liquid gallium-indium alloy. Processing, microstructures, and mechanical test results of these novel amalgams are presented and discussed in view of means to further improve their properties.

  8. Sonic-boom-induced building structure responses including damage.

    Science.gov (United States)

    Clarkson, B. L.; Mayes, W. H.

    1972-01-01

    Concepts of sonic-boom pressure loading of building structures and the associated responses are reviewed, and results of pertinent theoretical and experimental research programs are summarized. The significance of sonic-boom load time histories, including waveshape effects, are illustrated with the aid of simple structural elements such as beams and plates. Also included are discussions of the significance of such other phenomena as three-dimensional loading effects, air cavity coupling, multimodal responses, and structural nonlinearities. Measured deflection, acceleration, and strain data from laboratory models and full-scale building tests are summarized, and these data are compared, where possible, with predicted values. Damage complaint and claim experience due both to controlled and uncontrolled supersonic flights over communities are summarized with particular reference to residential, commercial, and historic buildings. Sonic-boom-induced building responses are compared with those from other impulsive loadings due to natural and cultural events and from laboratory simulation tests.

  9. Outcomes Among Pregnant Women Included in the Operation TOMODACHI Registry

    Science.gov (United States)

    2013-02-12

    Table 1 shows the status of potentially-exposed pregnancies. Pregnancy outcomes include live delivery, spontaneous loss, and induced abortion ...birth defects, which are defined according to the Case Definition of the National Birth Defects Prevention Network.3 Additional uses for these data...pregnancy outcome in the electronic medical data/records. Overall, the live delivery rates are quite high and the spontaneous loss rates are quite

  10. Rehabilitation of a triple amputee including a hip disarticulation.

    Science.gov (United States)

    Shin, J C; Park, C I; Kim, Y C; Jang, S H; Bang, I K; Shin, J S

    1998-12-01

    A multiple amputee more severe than a triple amputee is uncommon. There have been no reports on the rehabilitation outcome of a triple amputee, including hip disarticulation and transtibial amputation. The authors report the rehabilitation of a patient with left hip disarticulation, right trans-tibial amputation, and left trans-humeral amputation due to a train accident. He has successfully completed the rehabilitation programme and has become independent in prosthetic ambulation, activities of daily living, and driving.

  11. Search for BSM physics including dark matter at ATLAS

    CERN Document Server

    Ju, Xiangyang; The ATLAS collaboration

    2016-01-01

    The increased centre-of-mass energy of the proton-proton collisions of the LHC run 2 gives a unique opportunity to extend the sensitivity to the production of particles not foreseen by the Standard Model. This talk summarises recent ATLAS results on BSM searches. Although the focus is on searches for production of DM particles, results include searches for heavy resonances in many final states and for production of supersymmetric particles.

  12. Evaporative cooler including one or more rotating cooler louvers

    Energy Technology Data Exchange (ETDEWEB)

    Gerlach, David W

    2015-02-03

    An evaporative cooler may include an evaporative cooler housing with a duct extending therethrough, a plurality of cooler louvers with respective porous evaporative cooler pads, and a working fluid source conduit. The cooler louvers are arranged within the duct and rotatably connected to the cooler housing along respective louver axes. The source conduit provides an evaporative cooler working fluid to the cooler pads during at least one mode of operation.

  13. Circuit Modeling of a MEMS Varactor Including Dielectric Charging Dynamics

    Science.gov (United States)

    Giounanlis, P.; Andrade-Miceli, D.; Gorreta, S.; Pons-Nin, J.; Dominguez-Pumar, M.; Blokhina, E.

    2016-10-01

    Electrical models for MEMS varactors including the effect of dielectric charging dynamics are not available in commercial circuit simulators. In this paper a circuit model using lumped ideal elements available in the Cadence libraries and a basic Verilog-A model, has been implemented. The model has been used to simulate the dielectric charging in function of time and its effects over the MEMS capacitance value.

  14. Prenatal susceptibility to carcinogenesis by xenobiotic substances including vinyl chloride.

    OpenAIRE

    Rice, J M

    1981-01-01

    The carcinogenicity of vinyl chloride for experimental animals when administered transplacentally is reviewed in comparison with known transplacental carcinogens, including those that, like vinyl chloride, are dependent on enzyme-mediated metabolic conversion to a reactive intermediate in maternal or fetal tissues. Vinyl chloride is converted by mixed-function oxidases to the reactive metabolite chlorooxirane, the carcinogenicity of which is also reviewed. Vinyl chloride is unequivocally a tr...

  15. Tuneable photonic device including an array of metamaterial resonators

    Energy Technology Data Exchange (ETDEWEB)

    Brener, Igal; Wanke, Michael; Benz, Alexander

    2017-03-14

    A photonic apparatus includes a metamaterial resonator array overlying and electromagnetically coupled to a vertically stacked plurality of quantum wells defined in a semiconductor body. An arrangement of electrical contact layers is provided for facilitating the application of a bias voltage across the quantum well stack. Those portions of the semiconductor body that lie between the electrical contact layers are conformed to provide an electrically conductive path between the contact layers and through the quantum well stack.

  16. An Axisymmetrical Acoustic BEM Formulation Including Visco-Thermal Losses

    DEFF Research Database (Denmark)

    Cutanda Henriquez, Vicente; Juhl, Peter Møller

    2011-01-01

    dimensions. However, this is not usually true for small devices such as microphones, hearing aids, couplers, MEMS devices, mobile phones, etc., and then the losses need to be modeled. In this paper a numerical implementation of the Boundary Element Method (BEM) which includes visco-thermal losses...... of the boundary into elements is adequate and the problem has a manageable size. The method can be extended to full three-dimensional BEM....

  17. Chiral-scale effective theory including a dilatonic meson

    CERN Document Server

    Li, Yan-Ling; Rho, Mannque

    2016-01-01

    A scale-invariant chiral effective Lagrangian is constructed for octet pions and a dilaton figuring as Nambu-Goldstone bosons with vector mesons incorporated as hidden gauge fields. The Lagrangian is built to the next-to-leading order in chiral-scale counting without baryon fields and then to leading order including baryons. The resulting theory is hidden scale-symmetric and local symmetric. We also discuss some possible applications of the present Lagrangian.

  18. New chemical evolution analytical solutions including environment effects

    CERN Document Server

    Spitoni, E

    2015-01-01

    In the last years, more and more interest has been devoted to analytical solutions, including inflow and outflow, to study the metallicity enrichment in galaxies. In this framework, we assume a star formation rate which follows a linear Schmidt law, and we present new analytical solutions for the evolution of the metallicity (Z) in galaxies. In particular, we take into account environmental effects including primordial and enriched gas infall, outflow, different star formation efficiencies, and galactic fountains. The enriched infall is included to take into account galaxy-galaxy interactions. Our main results can be summarized as: i) when a linear Schmidt law of star formation is assumed, the resulting time evolution of the metallicity Z is the same either for a closed-box model or for an outflow model. ii) The mass-metallicity relation for galaxies which suffer a chemically enriched infall, originating from another evolved galaxy with no pre-enriched gas, is shifted down in parallel at lower Z values, if co...

  19. Electrolytes including fluorinated solvents for use in electrochemical cells

    Science.gov (United States)

    Tikhonov, Konstantin; Yip, Ka Ki; Lin, Tzu-Yuan

    2015-07-07

    Provided are electrochemical cells and electrolytes used to build such cells. The electrolytes include ion-supplying salts and fluorinated solvents capable of maintaining single phase solutions with the salts at between about -30.degree. C. to about 80.degree. C. The fluorinated solvents, such as fluorinated carbonates, fluorinated esters, and fluorinated esters, are less flammable than their non-fluorinated counterparts and increase safety characteristics of cells containing these solvents. The amount of fluorinated solvents in electrolytes may be between about 30% and 80% by weight not accounting weight of the salts. Fluorinated salts, such as fluoroalkyl-substituted LiPF.sub.6, fluoroalkyl-substituted LiBF.sub.4 salts, linear and cyclic imide salts as well as methide salts including fluorinated alkyl groups, may be used due to their solubility in the fluorinated solvents. In some embodiments, the electrolyte may also include a flame retardant, such as a phosphazene or, more specifically, a cyclic phosphazene and/or one or more ionic liquids.

  20. Transport Phenomena in Thin Rotating Liquid Films Including: Nucleate Boiling

    Science.gov (United States)

    Faghri, Amir

    2005-01-01

    In this grant, experimental, numerical and analytical studies of heat transfer in a thin liquid film flowing over a rotating disk have been conducted. Heat transfer coefficients were measured experimentally in a rotating disk heat transfer apparatus where the disk was heated from below with electrical resistance heaters. The heat transfer measurements were supplemented by experimental characterization of the liquid film thickness using a novel laser based technique. The heat transfer measurements show that the disk rotation plays an important role on enhancement of heat transfer primarily through the thinning of the liquid film. Experiments covered both momentum and rotation dominated regimes of the flow and heat transfer in this apparatus. Heat transfer measurements have been extended to include evaporation and nucleate boiling and these experiments are continuing in our laboratory. Empirical correlations have also been developed to provide useful information for design of compact high efficiency heat transfer devices. The experimental work has been supplemented by numerical and analytical analyses of the same problem. Both numerical and analytical results have been found to agree reasonably well with the experimental results on liquid film thickness and heat transfer Coefficients/Nusselt numbers. The numerical simulations include the free surface liquid film flow and heat transfer under disk rotation including the conjugate effects. The analytical analysis utilizes an integral boundary layer approach from which

  1. Modeling heart rate variability including the effect of sleep stages

    Science.gov (United States)

    Soliński, Mateusz; Gierałtowski, Jan; Żebrowski, Jan

    2016-02-01

    We propose a model for heart rate variability (HRV) of a healthy individual during sleep with the assumption that the heart rate variability is predominantly a random process. Autonomic nervous system activity has different properties during different sleep stages, and this affects many physiological systems including the cardiovascular system. Different properties of HRV can be observed during each particular sleep stage. We believe that taking into account the sleep architecture is crucial for modeling the human nighttime HRV. The stochastic model of HRV introduced by Kantelhardt et al. was used as the initial starting point. We studied the statistical properties of sleep in healthy adults, analyzing 30 polysomnographic recordings, which provided realistic information about sleep architecture. Next, we generated synthetic hypnograms and included them in the modeling of nighttime RR interval series. The results of standard HRV linear analysis and of nonlinear analysis (Shannon entropy, Poincaré plots, and multiscale multifractal analysis) show that—in comparison with real data—the HRV signals obtained from our model have very similar properties, in particular including the multifractal characteristics at different time scales. The model described in this paper is discussed in the context of normal sleep. However, its construction is such that it should allow to model heart rate variability in sleep disorders. This possibility is briefly discussed.

  2. The COG database: an updated version includes eukaryotes

    Directory of Open Access Journals (Sweden)

    Sverdlov Alexander V

    2003-09-01

    Full Text Available Abstract Background The availability of multiple, essentially complete genome sequences of prokaryotes and eukaryotes spurred both the demand and the opportunity for the construction of an evolutionary classification of genes from these genomes. Such a classification system based on orthologous relationships between genes appears to be a natural framework for comparative genomics and should facilitate both functional annotation of genomes and large-scale evolutionary studies. Results We describe here a major update of the previously developed system for delineation of Clusters of Orthologous Groups of proteins (COGs from the sequenced genomes of prokaryotes and unicellular eukaryotes and the construction of clusters of predicted orthologs for 7 eukaryotic genomes, which we named KOGs after eukaryotic orthologous groups. The COG collection currently consists of 138,458 proteins, which form 4873 COGs and comprise 75% of the 185,505 (predicted proteins encoded in 66 genomes of unicellular organisms. The eukaryotic orthologous groups (KOGs include proteins from 7 eukaryotic genomes: three animals (the nematode Caenorhabditis elegans, the fruit fly Drosophila melanogaster and Homo sapiens, one plant, Arabidopsis thaliana, two fungi (Saccharomyces cerevisiae and Schizosaccharomyces pombe, and the intracellular microsporidian parasite Encephalitozoon cuniculi. The current KOG set consists of 4852 clusters of orthologs, which include 59,838 proteins, or ~54% of the analyzed eukaryotic 110,655 gene products. Compared to the coverage of the prokaryotic genomes with COGs, a considerably smaller fraction of eukaryotic genes could be included into the KOGs; addition of new eukaryotic genomes is expected to result in substantial increase in the coverage of eukaryotic genomes with KOGs. Examination of the phyletic patterns of KOGs reveals a conserved core represented in all analyzed species and consisting of ~20% of the KOG set. This conserved portion of the

  3. Twelve tips for "flipping" the classroom.

    Science.gov (United States)

    Moffett, Jennifer

    2015-04-01

    The flipped classroom is a pedagogical model in which the typical lecture and homework elements of a course are reversed. The following tips outline the steps involved in making a successful transition to a flipped classroom approach. The tips are based on the available literature alongside the author's experience of using the approach in a medical education setting. Flipping a classroom has a number of potential benefits, for example increased educator-student interaction, but must be planned and implemented carefully to support effective learning.

  4. Growing pains: twelve lessons from corporate restructuring.

    Science.gov (United States)

    Gill, S L; Johnson, R L

    1988-05-01

    Corporate reorganization is a realignment of resources to enhance competitive strength and can follow one of two lines, vertical or horizontal. Whichever strategy is used, the reason for it remains unchanged: to provide a structural hierarchy through which strategic market niches are acquired and resources are economically deployed throughout the system. Healthcare corporate restructuring, however, is encountering growing pains, some of which were inevitable and others avoidable. When the healthcare organizational landscape is surveyed, 12 lessons can be learned about corporate reorganization: 1. Reorganization should be based on anticipated market and environmental conditions. 2. Form follows function. 3. Interdependence among multiple corporate units must be clearly acknowledged. 4. Reorganization is much more costly and politically charged than it appears at first. Reserved rights must be clearly defined. 6. The purpose and composition of the parent governing board must be distinguished from those of subsidiary boards. 7. Clarification of roles and relationships between the parent and subsidiaries is critical. 8. Unrealistic expectations of success should be confronted through up-front planning, negotiation, and creative problem solving. 9. False assumptions about corporate staffing needs create internal system warfare. 10. Physician support is crucial for success. 11. Hospital-based management skills and understanding may be inadequate for making personnel decisions in subsidiaries other than the hospital. 12. Competitive strategies must be strategically determined and must not be taken gamesmanship.

  5. Part Twelve: The Voyages of John Matthias

    OpenAIRE

    Printz-Påhlson, Göran

    2013-01-01

    In August 1974, when the Watergate scandal was moving into its last phase, the American poet John Matthias returned to his home, in South Bend, Indiana, after a year’s stay in England, traveling on the Polish ocean-liner Stefan Bathory. In June of 1976 he set out to sea again, this time on a Russian ship, the Mikhail Lermontov, in order to spend another year in England, as a Visiting Fellow in Poetry in Clare Hall, Cambridge. The voyages took approximately nine days each, and on both ships he...

  6. The Twelve Principles of CO2 CHEMISTRY.

    Science.gov (United States)

    Poliakoff, Martyn; Leitner, Walter; Streng, Emilia S

    2015-01-01

    This paper introduces a set of 12 Principles, based on the acronym CO2 CHEMISTRY, which are intended to form a set of criteria for assessing the viability of different processes or reactions for using CO2 as a feedstock for making organic chemicals. The principles aim to highlight the synergy of Carbon Dioxide Utilisation (CDU) with the components of green and sustainable chemistry as well as briefly pointing out the connection to the energy sector.

  7. The twelve principles of CO2 Chemistry

    OpenAIRE

    Poliakoff, Martyn; Leitner, Walter; Streng, Emelia S.

    2015-01-01

    This paper introduces a set of 12 Principles, based on the acronym CO2 CHEMISTRY, which are intended to form a set of criteria for assessing the viability of different processes or reactions for using CO2 as a feedstock for making organic chemicals. The principles aim to highlight the synergy of Carbon Dioxide Utilisation (CDU) with the components of green and sustainable chemistry as well as briefly pointing out the connection to the energy sector.

  8. Three-branes in twelve dimensions

    CERN Document Server

    Hewson, S F

    1999-01-01

    In this note we discuss the theory of super-threebranes in a spacetime of signature (10,2). Upon reduction, the threebrane provides us with the classical representations of the M-2-brane and the type IIB superstring. Many features of the original super (2+2)-brane theory are clarified. In particular, the (10,2) superspace and the spinors required to construct the brane action are discussed.

  9. Unintended Consequences: Twelve Years under the DMCA

    Science.gov (United States)

    Von Lohmann, Fred

    2010-01-01

    Since they were enacted in 1998, the "anti-circumvention" provisions of the Digital Millennium Copyright Act ("DMCA"), codified in section 1201 of the Copyright Act, have not been used as Congress envisioned. Congress meant to stop copyright infringers from defeating anti-piracy protections added to copyrighted works and to ban…

  10. SCIENCE FOR THE EIGHTS-TO-TWELVES.

    Science.gov (United States)

    RASMUSSEN, MARGARET; AND OTHERS

    THIS BULLETIN PREPARED FOR THE ASSOCIATION FOR CHILDHOOD EDUCATION INTERNATIONAL (ACEI) PROVIDES GUIDELINES FOR TEACHERS, ADMINISTRATORS, CONSULTANTS, SUPERVISORS, AND OTHERS WHO WORK WITH CHILDREN TO PROMOTE AND DEVELOP EFFECTIVE LEARNING EXPERIENCES FOR CHILDREN IN SCIENCE. THE PUBLICATION IS BASED ON THE PREMISE THAT EXPERIENCES THE CHILD HAS…

  11. Twelve steps to evaluating interprofessional education

    Directory of Open Access Journals (Sweden)

    Scott Reeves, PhD

    2016-12-01

    Full Text Available تضع هذه الورقة خطة؛ خطوة بخطوة لمساعدة القراء على تصميم وتطبيق وتوزيع تقاييم التعليم المتداخل بين التخصصات نقدم الإثنتي عشرة خطوة التالية التي تعتبر أساسية لهذه العملية: صياغة أسئلة التقييم, والاتفاق على نهج التقييم, واستخدام أطر للتقييم, والاعتماد على خبرات التقييم, ومراجعة الأدبيات, واختيار الأسلوب والتصميم, وتأمين الموافقة الأخلاقية, والوصول إلى البيانات, ومعالجة قضايا العمل الميداني, واستخدام أدوات التقييم, والنظر في الموارد, وخيارات التوزيع.

  12. Twelve years of Neandertal genetic discoveries

    DEFF Research Database (Denmark)

    Orlando, Ludovic Antoine Alexandre; Hänni, Catherine

    2011-01-01

    specimens have delivered authentic mitochondrial sequences. This information has helped us to better understand the evolution of the Neandertal gene pool over space and time and to address the long-standing question of possible admixture with their modern human relatives. This chapter reviews current...

  13. Twelve Traditional Chinese Paths to Good Health

    Institute of Scientific and Technical Information of China (English)

    JANE SHAW

    1994-01-01

    THESE 12 traditional Chinese practices were devised by our ancestors to maintain good health and are key to longevity. To bolster your health, try the following: 1. Move your eyes often. Ancient people called this exercise "yunjing" and believed moving the eyes could eliminate cataracts and nebulas and adjust myopia and farsightedness. First move the eyes from left to right and vice versa, then up and down and vice versa, 15 times each direction. Close your eyes tightly for a moment and then open them wide.

  14. Twelve Action Lines For a Better World

    Directory of Open Access Journals (Sweden)

    F. J. Radermacher

    2016-05-01

    Full Text Available This article describes a global governance system that—from the author’s point of view—would lead to sustainability and allow the implementation of the Sustainable Development Goals (SDGs, which have just been adopted at the UN level. Major elements are (1 the integration of existing international regimes in the area of the UN, WTO and the world financial system into an integrated “Global Governance Body”. (2 This institution would, among other functions, be responsible for the major global commons and put a fee on their usage with two aims: (i to protect them and (ii to generate money for financing global development and the SDGs. (3 To monitor the income and property distribution by politics with the political mandate, to keep it in the so-called “efficient inequality range”. This may need international co-financing. (4 It will, if done properly, prevent two-class societies, it will furthermore allow the building-up of social systems everywhere in the world with the aim to have a reasonable balance of wealth in all states, and also between states. (5 It will also be of help if artificial intelligence systems took over hundreds of millions of jobs for highly qualified people in the next decade. (6 This global institution would also be able to pay in defense of cultural diversity and for the protection of the environment, e.g. rainforests. (7 This would also allow us to do what is needed for avoiding uncontrolled climate change, e.g. improve the recent Paris accord concerning climate.

  15. Global anthropogenic emissions of particulate matter including black carbon

    Directory of Open Access Journals (Sweden)

    Z. Klimont

    2017-07-01

    Full Text Available This paper presents a comprehensive assessment of historical (1990–2010 global anthropogenic particulate matter (PM emissions including the consistent and harmonized calculation of mass-based size distribution (PM1, PM2. 5, PM10, as well as primary carbonaceous aerosols including black carbon (BC and organic carbon (OC. The estimates were developed with the integrated assessment model GAINS, where source- and region-specific technology characteristics are explicitly included. This assessment includes a number of previously unaccounted or often misallocated emission sources, i.e. kerosene lamps, gas flaring, diesel generators, refuse burning; some of them were reported in the past for selected regions or in the context of a particular pollutant or sector but not included as part of a total estimate. Spatially, emissions were calculated for 172 source regions (as well as international shipping, presented for 25 global regions, and allocated to 0.5°  ×  0.5° longitude–latitude grids. No independent estimates of emissions from forest fires and savannah burning are provided and neither windblown dust nor unpaved roads emissions are included. We estimate that global emissions of PM have not changed significantly between 1990 and 2010, showing a strong decoupling from the global increase in energy consumption and, consequently, CO2 emissions, but there are significantly different regional trends, with a particularly strong increase in East Asia and Africa and a strong decline in Europe, North America, and the Pacific region. This in turn resulted in important changes in the spatial pattern of PM burden, e.g. European, North American, and Pacific contributions to global emissions dropped from nearly 30 % in 1990 to well below 15 % in 2010, while Asia's contribution grew from just over 50 % to nearly two-thirds of the global total in 2010. For all PM species considered, Asian sources represented over 60 % of the global

  16. Global anthropogenic emissions of particulate matter including black carbon

    Science.gov (United States)

    Klimont, Zbigniew; Kupiainen, Kaarle; Heyes, Chris; Purohit, Pallav; Cofala, Janusz; Rafaj, Peter; Borken-Kleefeld, Jens; Schöpp, Wolfgang

    2017-07-01

    This paper presents a comprehensive assessment of historical (1990-2010) global anthropogenic particulate matter (PM) emissions including the consistent and harmonized calculation of mass-based size distribution (PM1, PM2. 5, PM10), as well as primary carbonaceous aerosols including black carbon (BC) and organic carbon (OC). The estimates were developed with the integrated assessment model GAINS, where source- and region-specific technology characteristics are explicitly included. This assessment includes a number of previously unaccounted or often misallocated emission sources, i.e. kerosene lamps, gas flaring, diesel generators, refuse burning; some of them were reported in the past for selected regions or in the context of a particular pollutant or sector but not included as part of a total estimate. Spatially, emissions were calculated for 172 source regions (as well as international shipping), presented for 25 global regions, and allocated to 0.5° × 0.5° longitude-latitude grids. No independent estimates of emissions from forest fires and savannah burning are provided and neither windblown dust nor unpaved roads emissions are included. We estimate that global emissions of PM have not changed significantly between 1990 and 2010, showing a strong decoupling from the global increase in energy consumption and, consequently, CO2 emissions, but there are significantly different regional trends, with a particularly strong increase in East Asia and Africa and a strong decline in Europe, North America, and the Pacific region. This in turn resulted in important changes in the spatial pattern of PM burden, e.g. European, North American, and Pacific contributions to global emissions dropped from nearly 30 % in 1990 to well below 15 % in 2010, while Asia's contribution grew from just over 50 % to nearly two-thirds of the global total in 2010. For all PM species considered, Asian sources represented over 60 % of the global anthropogenic total, and residential combustion

  17. Early Course in Obstetrics Increases Likelihood of Practice Including Obstetrics.

    Science.gov (United States)

    Pearson, Jennifer; Westra, Ruth

    2016-10-01

    The Department of Family Medicine and Community Health Duluth has offered the Obstetrical Longitudinal Course (OBLC) as an elective for first-year medical students since 1999. The objective of the OBLC Impact Survey was to assess the effectiveness of the course over the past 15 years. A Qualtrics survey was emailed to participants enrolled in the course from 1999-2014. Data was compiled for the respondent group as a whole as well as four cohorts based on current level of training/practice. Cross-tabulations with Fisher's exact test were applied and odds ratios calculated for factors affecting likelihood of eventual practice including obstetrics. Participation in the OBLC was successful in increasing exposure, awareness, and comfort in caring for obstetrical patients and feeling more prepared for the OB-GYN Clerkship. A total of 50.5% of course participants felt the OBLC influenced their choice of specialty. For participants who are currently physicians, 51% are practicing family medicine with obstetrics or OB-GYN. Of the cohort of family physicians, 65.2% made the decision whether to include obstetrics in practice during medical school. Odds ratios show the likelihood of practicing obstetrics is higher when participants have completed the OBLC and also are practicing in a rural community. Early exposure to obstetrics, as provided by the OBLC, appears to increase the likelihood of including obstetrics in practice, especially if eventual practice is in a rural community. This course may be a tool to help create a pipeline for future rural family physicians providing obstetrical care.

  18. Generalized fluid theory including non-Maxwellian kinetic effects

    Science.gov (United States)

    Izacard, Olivier

    2017-04-01

    The results obtained by the plasma physics community for the validation and the prediction of turbulence and transport in magnetized plasmas come mainly from the use of very central processing unit (CPU)-consuming particle-in-cell or (gyro)kinetic codes which naturally include non-Maxwellian kinetic effects. To date, fluid codes are not considered to be relevant for the description of these kinetic effects. Here, after revisiting the limitations of the current fluid theory developed in the 19th century, we generalize the fluid theory including kinetic effects such as non-Maxwellian super-thermal tails with as few fluid equations as possible. The collisionless and collisional fluid closures from the nonlinear Landau Fokker-Planck collision operator are shown for an arbitrary collisionality. Indeed, the first fluid models associated with two examples of collisionless fluid closures are obtained by assuming an analytic non-Maxwellian distribution function (e.g. the INMDF (Izacard, O. 2016b Kinetic corrections from analytic non-Maxwellian distribution functions in magnetized plasmas. Phys. Plasmas 23, 082504) that stands for interpreted non-Maxwellian distribution function). One of the main differences with the literature is our analytic representation of the distribution function in the velocity phase space with as few hidden variables as possible thanks to the use of non-orthogonal basis sets. These new non-Maxwellian fluid equations could initiate the next generation of fluid codes including kinetic effects and can be expanded to other scientific disciplines such as astrophysics, condensed matter or hydrodynamics. As a validation test, we perform a numerical simulation based on a minimal reduced INMDF fluid model. The result of this test is the discovery of the origin of particle and heat diffusion. The diffusion is due to the competition between a growing INMDF on short time scales due to spatial gradients and the thermalization on longer time scales. The results

  19. We need to include bystander first aid in trauma research.

    Science.gov (United States)

    Bakke, Håkon Kvåle; Wisborg, Torben

    2017-03-23

    The chain of trauma survival is a concept that originated in the area of out-of-hospital cardiac arrest (OHCA) and was adapted to the treatment of trauma. In out-of-hospital cardiac arrest research into bystander first aid has resulted in improved outcome. Whereas, in trauma research the first link of the chain of survival is almost ignored. In OHCA, cardiopulmonary resuscitation (CPR) from bystanders has been subject of a vast amount of research, as well as measures and programs to raise the rate of bystander CPR to cardiac arrest victims. These efforts have resulted in improved survival. The research effort has been well grounded in the research community, as demonstrated by its natural inclusion in the uniform reporting template (Utstein) for the treatment of OHCA. In trauma the bystander may contribute by providing an open airway, staunch bleedings, or prevent hypothermia. In trauma however, while the chain of survival has been adopted along with it distinct links, including bystander first aid, the consensus-based uniform reporting template for trauma (the Utstein template) does not include the bystander first aid efforts. There is extremely little research on what first aid measures bystanders provide to trauma victims, and on what impact such measures have on outcome. An important step to improve research on bystander first aid in trauma would be to include this as part of the uniform reporting template for trauma CONCLUSION: The lack of research on bystander first aid makes the first link in the trauma chain of survival the weakest link. We, the trauma research community, should either improve our research and knowledge in this area, or remove the link from the chain of survival.

  20. Extended 1D Method for Coherent Synchrotron Radiation including Shielding

    CERN Document Server

    Sagan, David; Mayes, Christopher; Sae-Ueng, Udom

    2008-01-01

    Coherent Synchrotron Radiation can severely limit the performance of accelerators designed for high brightness and short bunch length. Examples include light sources based on ERLs or FELs, and bunch compressors for linear colliders. In order to better simulate Coherent Synchrotron Radiation, the established 1-dimensional formalism is extended to work at lower energies, at shorter bunch lengths, and for an arbitrary configuration of multiple bends. Wide vacuum chambers are simulated by means of vertical image charges. This formalism has been implemented in the general beam dynamics code "Bmad" and its results are here compared to analytical approximations, to numerical solutions of the Maxwell equations, and to the simulation code "elegant".

  1. How to include farmers in the emission trading system?

    DEFF Research Database (Denmark)

    Svendsen, Gert Tinggaard

    2011-01-01

    The EU has committed itself to an ambitious 20 % reduction of greenhouse gases (GHG) by 2020 compared to the 1990 emissions level. Moreover, the EU goal beyond 2012 is to strengthen, expand and improve climate change initiatives. Therefore, there is a strong need to consider more carefully how to...... to integrate as many sectors as possible in these efforts. Farmers, however, do not trade GHG under the Kyoto agreement. The idea of including farmers in a national emission trading system has been launched in Australia but it has not yet been applied to the EU....

  2. Ground state of a confined Yukawa plasma including correlation effects

    CERN Document Server

    Henning, C; Filinov, A; Piel, A; Bonitz, M

    2007-01-01

    The ground state of an externally confined one-component Yukawa plasma is derived analytically using the local density approximation (LDA). In particular, the radial density profile is computed. The results are compared with the recently obtained mean-field (MF) density profile \\cite{henning.pre06}. While the MF results are more accurate for weak screening, LDA with correlations included yields the proper description for large screening. By comparison with first-principle simulations for three-dimensional spherical Yukawa crystals we demonstrate that both approximations complement each other. Together they accurately describe the density profile in the full range of screening parameters.

  3. Endometrial cancer risk prediction including serum-based biomarkers

    DEFF Research Database (Denmark)

    Fortner, Renée T; Hüsing, Anika; Kühn, Tilman;

    2017-01-01

    Endometrial cancer risk prediction models including lifestyle, anthropometric, and reproductive factors have limited discrimination. Adding biomarker data to these models may improve predictive capacity; to our knowledge, this has not been investigated for endometrial cancer. Using a nested case......-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we investigated the improvement in discrimination gained by adding serum biomarker concentrations to risk estimates derived from an existing risk prediction model based on epidemiologic factors. Serum...... concentrations of sex steroid hormones, metabolic markers, growth factors, adipokines, and cytokines were evaluated in a step-wise backward selection process; biomarkers were retained at pdiscrimination was assessed using...

  4. How to include farmers in the emission trading system?

    DEFF Research Database (Denmark)

    Svendsen, Gert Tinggaard

    2011-01-01

    The EU has committed itself to an ambitious 20 % reduction of greenhouse gases (GHG) by 2020 compared to the 1990 emissions level. Moreover, the EU goal beyond 2012 is to strengthen, expand and improve climate change initiatives. Therefore, there is a strong need to consider more carefully how to...... to integrate as many sectors as possible in these efforts. Farmers, however, do not trade GHG under the Kyoto agreement. The idea of including farmers in a national emission trading system has been launched in Australia but it has not yet been applied to the EU....

  5. Generalized fluid theory including non-Maxwellian kinetic effects

    OpenAIRE

    Izacard, Olivier

    2016-01-01

    The results obtained by the plasma physics community for the validation and the prediction of turbulence and transport in magnetized plasma come mainly from the use of very CPU-consuming particle-in-cell or (gyro)kinetic codes which naturally include non-Maxwellian kinetic effects. To date, fluid codes are not considered to be relevant for the description of these kinetic effects. Here, after revisiting the limitations of the current fluid theory developed in the 19th century, we generalize t...

  6. Harmonic measure for percolation and ising clusters including rare events.

    Science.gov (United States)

    Adams, David A; Sander, Leonard M; Ziff, Robert M

    2008-10-03

    We obtain the harmonic measure of the hulls of critical percolation clusters and Ising-model Fortuin-Kastelyn clusters using a biased random-walk sampling technique which allows us to measure probabilities as small as 10{-300}. We find the multifractal D(q) spectrum including regions of small and negative q. Our results for external hulls agree with Duplantier's theoretical predictions for D(q) and his exponent -23/24 for the harmonic measure probability distribution for percolation. For the complete hull, we find the probability decays with an exponent of -1 for both systems.

  7. The action principle for generalized fluid motion including gyroviscosity

    CERN Document Server

    Lingam, M

    2014-01-01

    A general set of fluid equations that allow for energy-conserving momentum transport by gyroscopic motion of fluid elements is obtained. The equations are produced by a class of action principles that yield a large subset of the known fluid and magnetofluid models, including gyroviscosity. Analysis of the action principle yields broad, model-independent results regarding the conservation laws of energy and linear and angular momenta. The formalism is illustrated by studying fluid models with intrinsic angular momentum that may appear in the contexts of condensed matter, biological, and other areas of physics.

  8. Analysis of mathematical model for long-primary short-secondary twelve-phase linear induction motor%长初级短次级十二相直线感应电动机数学模型分析

    Institute of Scientific and Technical Information of China (English)

    饶金; 刘德志; 许金; 马伟明; 徐兴华

    2014-01-01

    To meet the requirement of the high-power linear propulsion system ,this paper designs a novel twelve-phase linear induction motor (LIM ) with double-sided long stators ,and presents its winding construction .On this basis ,a mathematical model of ABC coordinates for this novel motor is derived ,which is used to analyze the asymmetry of the end-winding leakage inductance in the twelve-phase LIM with double-sided long stators ,which is caused by the relative space position of each phase end-winding in the motor ,and compare it with the asymmetry of the end-winding leakage inductance of the multi-phase rotating motor .Thus ,a simulation model of the motor is established .The model is used for calculating the electromagnetic properties of the motor .The simulation results prove that the mathematical model is correct .%基于大功率直线推进的要求,设计了一种新型十二相双边长定子直线感应电动机,介绍了十二相直线感应电动机的绕组结构。在此基础上,推导了十二相双边长定子直线感应电动机的ABC坐标系数学模型,分析了由电机各相端部绕组空间相对位置决定的十二相直线感应电动机端部漏感的不对称规律,并与多相旋转电机端部漏感的规律进行了对比分析;建立了仿真模型,对电机的电磁性能进行了计算。仿真实验证明了该数学模型的正确性。

  9. Botox, tratamiento fútil en pacientes menores de doce años de edad con espasticidad Botox: A futile treatment for patients under twelve years of age suffering from muscle spasticity

    Directory of Open Access Journals (Sweden)

    Lira López Lirled

    2008-08-01

    Full Text Available El artículo sostiene la futilidad del Botox cuando éste se aplica en pacientes menores de doce años de edad con espasticidad, basándose principalmente en estudios realizados por diversos investigadores que plantean el actuar del fármaco sobre el cuerpo. Al tiempo que propone ampliar la visión en la atención de la discapacidad, partiendo de la persona como un ser integral, ubicándolo en su historia personal, en sus capacidades y etapa de la vida en que se encuentra, sin que se restrinja solo a la corporeidad del paciente. Plantea que los pacientes menores de doce años con espasticidad son personas que se encuentran en proceso de desarrollar sus capacidades y potencializarlas, la espasticidad se manifiesta por una triada: hipertonía, hiperrreflexia y reflejos patológicos, lo que limita la movilidad pero no la obstruye. Es resultado de la secuela de una lesión en las vías córtico espinales, por lo que el tratamiento debe de ir más allá de las expresiones corporales que el paciente hace evidente durante la realización de movimientos voluntarios.The following article presents the research of multiple investigators about the futility of Botox when this drug is applied on patients younger than twelve years old and the effects of the body of the subjects. At the same time invites to amply the vision on the attention of disability, taking the person as a complete being, placing his or hers personal history, his or hers capacities and the life phase he or she is living actually. Also shows that the patients with spasticity younger than twelve years old are people who is on process of developing his or hers capabilities and potencialize them, the spasticity is a sequel of injury on cortical spinal routes that manifest hypertonic, hiperreflex and pathologic reflexes that limit the mobility but do not impede it, so the treatment must be beyond corporal expressions that the patient made evident during the voluntary movement realization.

  10. Constant-Pressure Combustion Charts Including Effects of Diluent Addition

    Science.gov (United States)

    Turner, L Richard; Bogart, Donald

    1949-01-01

    Charts are presented for the calculation of (a) the final temperatures and the temperature changes involved in constant-pressure combustion processes of air and in products of combustion of air and hydrocarbon fuels, and (b) the quantity of hydrocarbon fuels required in order to attain a specified combustion temperature when water, alcohol, water-alcohol mixtures, liquid ammonia, liquid carbon dioxide, liquid nitrogen, liquid oxygen, or their mixtures are added to air as diluents or refrigerants. The ideal combustion process and combustion with incomplete heat release from the primary fuel and from combustible diluents are considered. The effect of preheating the mixture of air and diluents and the effect of an initial water-vapor content in the combustion air on the required fuel quantity are also included. The charts are applicable only to processes in which the final mixture is leaner than stoichiometric and at temperatures where dissociation is unimportant. A chart is also included to permit the calculation of the stoichiometric ratio of hydrocarbon fuel to air with diluent addition. The use of the charts is illustrated by numerical examples.

  11. Generalized fluid theory including non-Maxwellian kinetic effects

    CERN Document Server

    Izacard, Olivier

    2016-01-01

    The results obtained by the plasma physics community for the validation and the prediction of turbulence and transport in magnetized plasma come mainly from the use of very CPU-consuming particle-in-cell or (gyro)kinetic codes which naturally include non-Maxwellian kinetic effects. To date, fluid codes are not considered to be relevant for the description of these kinetic effects. Here, after revisiting the limitations of the current fluid theory developed in the 19th century, we generalize the fluid theory including kinetic effects such as non-Maxwellian super-thermal tails with as few fluid equations as possible. The collisionless and collisional fluid closures from the nonlinear Landau Fokker-Planck collision operator are shown for an arbitrary collisionality. Indeed, the first fluid models associated with two examples of collisionless fluid closures are obtained by assuming an analytic non-Maxwellian distribution function (e.g., the INMDF [O. Izacard, Phys. Plasmas 23, 082504 (2016)]). One of the main dif...

  12. TOOLS TO INCLUDE BLIND STUDENTS IN SCHOOL BUILDING PERFORMANCE ASSESSMENTS

    Directory of Open Access Journals (Sweden)

    Tania Pietzschke Abate

    2016-05-01

    Full Text Available This article discusses the design of data collection instruments that include the opinions of blind students, in accordance with the principles of Universal Design (UD. The aim of this study is to understand the importance of adapting data collection instruments for the inclusion of disabled persons in field research in Architecture and Design, among other fields. The data collection instruments developed were a play interview with a tactile map and a 3D survey with the use of tactile models. These instruments sought to assess the school environment experienced by blind students. The study involved students from the early years of a school for the blind who had not yet mastered the Braille system. The participation of these students was evaluated. A multidisciplinary team consisting of architects, designers, educators, and psychologists lent support to the study. The results showed that the data collection instruments adapted to blind students were successful in making the group of authors examine questions regarding UD. An analysis of the participatory phase showed that the limitations resulting from blindness determine the specificities in the adaptation and implementation process of the instruments in schools. Practical recommendations for future studies related to instruments in the UD thematic are presented. This approach is in line with the global trend of including disabled persons in society based on these users’ opinions concerning what was designed by architects and designers.

  13. Risk Factors for Breast Cancer, Including Occupational Exposures

    Directory of Open Access Journals (Sweden)

    Elisabete Weiderpass

    2011-03-01

    Full Text Available The knowledge on the etiology of breast cancer has advanced substantially in recent years, and several etiological factors are now firmly established. However, very few new discoveries have been made in relation to occupational risk factors. The International Agency for Research on Cancer has evaluated over 900 different exposures or agents to-date to determine whether they are carcinogenic to humans. These evaluations are published as a series of Monographs (www.iarc.fr. For breast cancer the following substances have been classified as “carcinogenic to humans” (Group 1: alcoholic beverages, exposure to diethylstilbestrol, estrogen-progestogen contraceptives, estrogen-progestogen hormone replacement therapy and exposure to X-radiation and gamma-radiation (in special populations such as atomic bomb survivors, medical patients, and in-utero exposure. Ethylene oxide is also classified as a Group 1 carcinogen, although the evidence for carcinogenicity in epidemiologic studies, and specifically for the human breast, is limited. The classification “probably carcinogenic to humans” (Group 2A includes estrogen hormone replacement therapy, tobacco smoking, and shift work involving circadian disruption, including work as a flight attendant. If the association between shift work and breast cancer, the most common female cancer, is confirmed, shift work could become the leading cause of occupational cancer in women.

  14. Global Analysis of Solar Neutrino Oscillations Including SNO CC Measurement

    CERN Document Server

    Bahcall, J N; Peña-Garay, C; Bahcall, John N; Peña-Garay, Carlos

    2001-01-01

    For active and sterile neutrinos, we present the globally allowed solutions for two neutrino oscillations. We include the SNO CC measurement and all other relevant solar neutrino and reactor data. Five active neutrino oscillation solutions (LMA, LOW, SMA, VAC, and Just So2) are currently allowed at 3 sigma; three sterile neutrino solutions (Just So2, SMA, and VAC) are allowed at 3 sigma. The goodness of fit is satisfactory for all eight solutions. We also investigate the robustness of the allowed solutions by carrying out global analyses with and without: 1) imposing solar model constraints on the 8B neutrino flux, 2) including the Super-Kamiokande spectral energy distribution and day-night data, 3) using an enhanced CC cross section for deuterium (due to radiative corrections), and 4) a optimistic, hypothetical reduction by a factor of three of the error of the SNO CC rate. For every analysis strategy used in this paper, the most favored solutions all involve large mixing angles: LMA, LOW, or VAC. The favore...

  15. Risk factors for breast cancer, including occupational exposures.

    Science.gov (United States)

    Weiderpass, Elisabete; Meo, Margrethe; Vainio, Harri

    2011-03-01

    The knowledge on the etiology of breast cancer has advanced substantially in recent years, and several etiological factors are now firmly established. However, very few new discoveries have been made in relation to occupational risk factors. The International Agency for Research on Cancer has evaluated over 900 different exposures or agents to-date to determine whether they are carcinogenic to humans. These evaluations are published as a series of Monographs (www.iarc.fr). For breast cancer the following substances have been classified as "carcinogenic to humans" (Group 1): alcoholic beverages, exposure to diethylstilbestrol, estrogen-progestogen contraceptives, estrogen-progestogen hormone replacement therapy and exposure to X-radiation and gamma-radiation (in special populations such as atomic bomb survivors, medical patients, and in-utero exposure). Ethylene oxide is also classified as a Group 1 carcinogen, although the evidence for carcinogenicity in epidemiologic studies, and specifically for the human breast, is limited. The classification "probably carcinogenic to humans" (Group 2A) includes estrogen hormone replacement therapy, tobacco smoking, and shift work involving circadian disruption, including work as a flight attendant. If the association between shift work and breast cancer, the most common female cancer, is confirmed, shift work could become the leading cause of occupational cancer in women.

  16. Including International Aviation in the EU Emissions Trading Scheme

    Energy Technology Data Exchange (ETDEWEB)

    Kopsch, Fredrik

    2011-07-01

    Starting on January 1 st, 2012, the international aviation sector will be included into the already existing EU ETS. All air crafts departing and arriving within the European Union will be obliged to hold permits corresponding to their total emissions of CO{sub 2} for those routes. Since emissions from the international aviation sector are not included under the Kyoto Protocol, the European Commission has decided to introduce a trading barrier between the sectors in order not to jeopardize the Kyoto targets. The purpose of this paper is to analyse the potential loss in cost-effectiveness of introducing such a trading barrier between two sectors taking into account that damage from emissions is not necessarily uniform. A theoretical model is developed to address the question and it is found that, at least for the case with linking the international aviation sector to the stationary sources within the EU ETS, the trading barrier might be unwarranted as it might lead to higher damage from emissions as compared to alternative ways to link the trading sectors. However, it should be stressed that this finding is not general and caution should be taken in the future when linking emission trading schemes as, depending on the heterogeneity of emission damage, a trading barrier might very well be justified

  17. The Diversification Benefits of Including Carbon Assets in Financial Portfolios

    Directory of Open Access Journals (Sweden)

    Yinpeng Zhang

    2017-03-01

    Full Text Available Carbon allowances traded in the EU-Emission Trading Scheme (EU-ETS were initially designed as an economic motivation for efficiently curbing greenhouse as emissions, but now it mimics quite a few characteristics of financial assets, and have now been used as a candidate product in building financial portfolios. In this study, we examine the time-varying correlations between carbon allowance prices with other financial indices, during the third phase of EU-ETS. The results show that, at the beginning of this period, carbon price was still strongly corrected with other financial indices. However, this connection was weakened over time. Given the relative independence of carbon assets from other financial assets, we argue for the diversification benefits of including carbon assets in financial portfolios, and building such portfolios, respectively, with the traditional global minimum variance (GMV strategy, the mean-variance-OGARCH (MV-OGARCH strategy, and the dynamic conditional correlation (DCC strategy. It is shown that the portfolio built with the MV-OGARCH strategy far out-performs the others and that including carbon assets in financial portfolios does help reduce investment risks.

  18. Remote observations of reentering spacecraft including the space shuttle orbiter

    Science.gov (United States)

    Horvath, Thomas J.; Cagle, Melinda F.; Grinstead, Jay H.; Gibson, David M.

    Flight measurement is a critical phase in development, validation and certification processes of technologies destined for future civilian and military operational capabilities. This paper focuses on several recent NASA-sponsored remote observations that have provided unique engineering and scientific insights of reentry vehicle flight phenomenology and performance that could not necessarily be obtained with more traditional instrumentation methods such as onboard discrete surface sensors. The missions highlighted include multiple spatially-resolved infrared observations of the NASA Space Shuttle Orbiter during hypersonic reentry from 2009 to 2011, and emission spectroscopy of comparatively small-sized sample return capsules returning from exploration missions. Emphasis has been placed upon identifying the challenges associated with these remote sensing missions with focus on end-to-end aspects that include the initial science objective, selection of the appropriate imaging platform and instrumentation suite, target flight path analysis and acquisition strategy, pre-mission simulations to optimize sensor configuration, logistics and communications during the actual observation. Explored are collaborative opportunities and technology investments required to develop a next-generation quantitative imaging system (i.e., an intelligent sensor and platform) with greater capability, which could more affordably support cross cutting civilian and military flight test needs.

  19. Chronic lymphocytic leukemia: a clinical review including Korean cohorts

    Science.gov (United States)

    Jeon, Young-Woo; Cho, Seok-Goo

    2016-01-01

    Only 5th decade ago, chronic lymphocytic leukemia (CLL) was only recognized as disease group of presenting features like peripheral lymphocytosis, organomegaly including of splenomegaly. As understanding of disease biology and molecular diagnostic tools are getting improved gradually, characterization of variation in CLL’s clinical courses was facilitated, resulting in better risk stratification and targeted treatments. Consequently multiple new targeted agents have been used in treatment of CLL, it makes improved clinical outcome. Rituximab containing chemoimmunotherapy (combination of rituximab, fludarabine, and cyclophosphamide) have shown better overall response rate and progression-free survival on fit patients’ group in front-line setting, result in standard first-line therapeutic option for CLL. Furthermore, after introducing that the B-cell receptor is crucial for the evolution and progression of CLL, emerging treatments targeting highly activated surface antigens and oncogenic signaling pathways have been associated with several successes in recent decades. These include new anti-CD 20 monoclonal antibody (obinutuzumab), the bruton tyrosine kinase inhibitor (ibrutinib), the phosphatidylinositol 3-kinase inhibitor (idelalisib), and B-cell CLL/lymphoma 2 inhibitor (ABT-199 and ABT-263). So, we discuss not only general pathophysiology of CLL, but also rapidly advancing treatment strategies that are being studied or approved for treatment of CLL. PMID:27044858

  20. Proposal to Include Electrical Energy in the Industrial Return Statistics

    CERN Document Server

    2003-01-01

    At its 108th session on the 20 June 1997, the Council approved the Report of the Finance Committee Working Group on the Review of CERN Purchasing Policy and Procedures. Among other topics, the report recommended the inclusion of utility supplies in the calculation of the return statistics as soon as the relevant markets were deregulated, without reaching a consensus on the exact method of calculation. At its 296th meeting on the 18 June 2003, the Finance Committee approved a proposal to award a contract for the supply of electrical energy (CERN/FC/4693). The purpose of the proposal in this document is to clarify the way electrical energy will be included in future calculations of the return statistics. The Finance Committee is invited: 1. to agree that the full cost to CERN of electrical energy (excluding the cost of transport) be included in the Industrial Service return statistics; 2. to recommend that the Council approves the corresponding amendment to the Financial Rules set out in section 2 of this docum...

  1. Magnetic properties of nickel halide hydrates including deuteration effects

    Science.gov (United States)

    DeFotis, G. C.; Van Dongen, M. J.; Hampton, A. S.; Komatsu, C. H.; Trowell, K. T.; Havas, K. C.; Davis, C. M.; DeSanto, C. L.; Hays, K.; Wagner, M. J.

    2017-01-01

    Magnetic measurements on variously hydrated nickel chlorides and bromides, including deuterated forms, are reported. Results include locations and sizes of susceptibility maxima, Tmax and χmax, ordering temperatures Tc, Curie constants and Weiss theta in the paramagnetic regime, and primary and secondary exchange interactions from analysis of low temperature data. For the latter a 2D Heisenberg model augmented by interlayer exchange in a mean-field approximation is applied. Magnetization data to 16 kG as a function of temperature show curvature and hysteresis characteristics quite system dependent. For four materials high field magnetization data to 70 kG at 2.00 K are also obtained. Comparison is made with theoretical relations for spin-1 models. Trends are apparent, primarily that Tmax of each bromide hydrate is less than for the corresponding chloride, and that for a given halide nD2O (n=1 or 2) deuterates exhibit lesser Tmax than do nH2O hydrates. A monoclinic unit cell determined from powder X-ray diffraction data on NiBr2·2D2O is different from and slightly larger than that of NiBr2·2H2O. This provides some rationale for the difference in magnetic properties between these.

  2. A Mixed Mode Cochlear Amplifier Including Neural Feedback

    Science.gov (United States)

    Flax, Matthew R.; Holmes, W. Harvey

    2011-11-01

    The mixed mode cochlear amplifier (MMCA) model is derived from the physiology of the cochlea. It is comprised of three main elements of the peripheral hearing system: the cochlear mechanics, hair cell motility, and neurophysiology. This model expresses both active compression wave and active traveling wave modes of operation. The inclusion of a neural loop with a time delay, and a new paradigm for the mechanical response of the outer hair cells, are believed to be unique features of the MMCA. These elements combine to form an active feedback loop to constitute the cochlear amplifier, whose input is a passive traveling wave vibration. The result is a cycle-by-cycle amplifier with nonlinear response. This system can assume an infinite number of different operating states. The stable state and the first few amplitude-limited unstable (Hopf-bifurcated) states are significant in describing the operation of the peripheral hearing system. A hierarchy of models can be constructed from this concept, depending on the amount of detail included. The simplest model of the MMCA is a nonlinear delay line resonator. It was found that even this simple MMCA version can explain a large number of hearing phenomena, at least qualitatively. This paper concentrates on explaining the fractional octave shift from the living to postmortem response in terms of the new model. Other mechanical, hair cell and neurological phenomena can also be accounted for by the MMCA, including two-tone suppression behavior, distortion product responses, otoacoustic emissions and neural spontaneous rates.

  3. Kabuki syndrome: expanding the phenotype to include microphthalmia and anophthalmia.

    Science.gov (United States)

    McVeigh, Terri P; Banka, Siddharth; Reardon, William

    2015-10-01

    Kabuki syndrome is a rare genetic malformation syndrome that is characterized by distinct facies, structural defects and intellectual disability. Kabuki syndrome may be caused by mutations in one of two histone methyltransferase genes: KMT2D and KDM6A. We describe a male child of nonconsanguineous Irish parents presenting with multiple malformations, including bilateral extreme microphthalmia; cleft palate; congenital diaphragmatic hernia; duplex kidney; as well as facial features of Kabuki syndrome, including interrupted eyebrows and lower lid ectropion. A de-novo germline mutation in KMT2D was identified. Whole-exome sequencing failed to reveal mutations in any of the known microphthalmia/anopthalmia genes. We also identified four other patients with Kabuki syndrome and microphthalmia. We postulate that Kabuki syndrome may produce this type of ocular phenotype as a result of extensive interaction between KMT2D, WAR complex proteins and PAXIP1. Children presenting with microphthalmia/anophthalmia should be examined closely for other signs of Kabuki syndrome, especially at an age where the facial gestalt might be less readily appreciable.

  4. Evaluation of FEMA-440 for including soil-structure interaction

    Institute of Scientific and Technical Information of China (English)

    Khoshnoudian F.; Behmanesh I.

    2010-01-01

    Replacing the entire soil-structure system with a fixed base oscillator to consider the effect of soil-structure interaction (SSI) is a common analysis method in seismic design. This technique has been included in design procedures such as NEHRP, ASCE, etc. By defining an equivalent fundamental period and damping ratio that can modify the response of the structure. However, recent studies indicate that the effects of SSI should be reconsidered when a structure undergoes a nonlinear displacement demand. In recent documents on Nonlinear Static Procedures (NSPs), FEMA-440 (2005), a modified damping ratio of the replacement oscillator was proposed by introducing the ductility of the soil-structure system obtained from pushover analysis. In this paper, the damping defined in FEMA-440 to include the soil-structure interaction effect is evaluated, and the accuracy of the Coefficiem Method given in FEMA-440 and the Equivalent Linearization Method is studied. Although the improvements for Nonlinear Static Procedures (NSPs) in FEMA-440 are achieved for a fixed base SDOF structure, the soil effects are not perfectly obtained. Furthermore, the damping definition of a soil-structure system is extended to structures to consider bilinear behavior.

  5. Study on `Tannix` an absorbent for heavy metals including uranium

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, Yasuo [Mitsubishi Nuclear Fuel Co. Ltd., Tokyo (Japan)

    1997-09-01

    To treat radioactive wastes including uranium and transuranic elements such as plutonium, americium etc., development of an absorbent which can be used to absorb and isolate these elements without producing secondary wastes after treatment was attempted. And an absorbent has been successfully developed by polymerizing tannin, a natural product. It is known that tannin binds heavy metals including uranium resulting to produce their precipitates. There are some reports suggesting its absorption ability for uranium. However, tannin has not been used to isolate a heavy metal from a solution because it is soluble in water. Here, insolubilization of tannin was attempted and a manufacturing method for a gelatinized insoluble tannin named as ``Tannix`` was established. Wattle tannin extracted from Mimosa pudica produced in Africa was dissolved in an alkaline solution and gelatinized by heating after the addition of formalin. Thus obtained insoluble tannin was used after crushing and sieving. This product, ``Tannix`` was able to absorb more than 99% of uranium in the waste. And the absorbed Tannin could be degraded by incineration even at a low temperature, leaving only uranium, but not producing any secondary product. (M.N.)

  6. Community Assessment Tool for Public Health Emergencies Including Pandemic Influenza

    Energy Technology Data Exchange (ETDEWEB)

    ORAU' s Oak Ridge Institute for Science Education (HCTT-CHE)

    2011-04-14

    The Community Assessment Tool (CAT) for Public Health Emergencies Including Pandemic Influenza (hereafter referred to as the CAT) was developed as a result of feedback received from several communities. These communities participated in workshops focused on influenza pandemic planning and response. The 2008 through 2011 workshops were sponsored by the Centers for Disease Control and Prevention (CDC). Feedback during those workshops indicated the need for a tool that a community can use to assess its readiness for a disaster - readiness from a total healthcare perspective, not just hospitals, but the whole healthcare system. The CAT intends to do just that - help strengthen existing preparedness plans by allowing the healthcare system and other agencies to work together during an influenza pandemic. It helps reveal each core agency partners (sectors) capabilities and resources, and highlights cases of the same vendors being used for resource supplies (e.g., personal protective equipment [PPE] and oxygen) by the partners (e.g., public health departments, clinics, or hospitals). The CAT also addresses gaps in the community's capabilities or potential shortages in resources. This tool has been reviewed by a variety of key subject matter experts from federal, state, and local agencies and organizations. It also has been piloted with various communities that consist of different population sizes, to include large urban to small rural communities.

  7. APORTACIONES DE LA INVESTIGACIÓN EUROPEA INCLUD-ED PARA LA REDUCCIÓN DEL ABANDONO ESCOLAR PREMATURO

    Directory of Open Access Journals (Sweden)

    Maria Padrós Cuxart

    2011-05-01

    Full Text Available The challenge of reducing early school leaving in Europe, with special pressure in Spain, leads to the need of evidence based educational policies and measures. This paper presents measures to prevend and reduce early school leaving that have been identified within the research Project INCLUD-ED. Strategies for inclusion and social cohesion in Europe from education. This is the research Project with a higher level and resources developed  since now  in Europe regarding school education. The identified solutions are already being addressed in documents of the European Commission, such as the recent Communication to the European Parliament "Tackiling early school leaving: a key contribution to the Europe 2020 Agenda".

  8. Generalized fluid theory including non-Maxwellian kinetic effects

    Energy Technology Data Exchange (ETDEWEB)

    Izacard, Olivier

    2017-03-29

    The results obtained by the plasma physics community for the validation and the prediction of turbulence and transport in magnetized plasmas come mainly from the use of very central processing unit (CPU)-consuming particle-in-cell or (gyro)kinetic codes which naturally include non-Maxwellian kinetic effects. To date, fluid codes are not considered to be relevant for the description of these kinetic effects. Here, after revisiting the limitations of the current fluid theory developed in the 19th century, we generalize the fluid theory including kinetic effects such as non-Maxwellian super-thermal tails with as few fluid equations as possible. The collisionless and collisional fluid closures from the nonlinear Landau Fokker–Planck collision operator are shown for an arbitrary collisionality. Indeed, the first fluid models associated with two examples of collisionless fluid closures are obtained by assuming an analytic non-Maxwellian distribution function (e.g. the INMDF (Izacard, O. 2016b Kinetic corrections from analytic non-Maxwellian distribution functions in magnetized plasmas.Phys. Plasmas23, 082504) that stands for interpreted non-Maxwellian distribution function). One of the main differences with the literature is our analytic representation of the distribution function in the velocity phase space with as few hidden variables as possible thanks to the use of non-orthogonal basis sets. These new non-Maxwellian fluid equations could initiate the next generation of fluid codes including kinetic effects and can be expanded to other scientific disciplines such as astrophysics, condensed matter or hydrodynamics. As a validation test, we perform a numerical simulation based on a minimal reduced INMDF fluid model. The result of this test is the discovery of the origin of particle and heat diffusion. The diffusion is due to the competition between a growing INMDF on short time scales due to spatial gradients and the thermalization on longer time

  9. PROPERTIES AND MICROSTRUCTURE OF CEMENT PASTE INCLUDING RECYCLED CONCRETE POWDER

    Directory of Open Access Journals (Sweden)

    Jaroslav Topič

    2017-02-01

    Full Text Available The disposal and further recycling of concrete is being investigated worldwide, because the issue of complete recycling has not yet been fully resolved. A fundamental difficulty faced by researchers is the reuse of the recycled concrete fines which are very small (< 1 mm. Currently, full recycling of such waste fine fractions is highly energy intensive and resulting in production of CO2. Because of this, the only recycling methods that can be considered as sustainable and environmentally friendly are those which involve recycled concrete powder (RCP in its raw form. This article investigates the performance of RCP with the grain size < 0.25 mm as a potential binder replacement, and also as a microfiller in cement-based composites. Here, the RCP properties are assessed, including how mechanical properties and the microstructure are influenced by increasing the amount of the RCP in a cement paste (≤ 25 wt%.

  10. Neutrinos from Cosmic Accelerators including Magnetic Field and Flavor Effects

    Directory of Open Access Journals (Sweden)

    Walter Winter

    2012-01-01

    Full Text Available We review the particle physics ingredients affecting the normalization, shape, and flavor composition of astrophysical neutrinos fluxes, such as different production modes, magnetic field effects on the secondaries (muons, pions, and kaons, and flavor mixing, where we focus on pγ interactions. We also discuss the interplay with neutrino propagation and detection, including the possibility to detect flavor and its application in particle physics, and the use of the Glashow resonance to discriminate pγ from pp interactions in the source. We illustrate the implications on fluxes and flavor composition with two different models: (1 the target photon spectrum is dominated by synchrotron emission of coaccelerated electrons and (2 the target photon spectrum follows the observed photon spectrum of gamma-ray bursts. In the latter case, the multimessenger extrapolation from the gamma-ray fluence to the expected neutrino flux is highlighted.

  11. Sea Surface Temperature from EUMETSAT Including Sentinel-3 SLSTR

    Science.gov (United States)

    O'Carroll, Anne; Bonekamp, Hans; Montagner, Francois; Santacesaria, Vincenzo; Tomazic, Igor

    2015-12-01

    The paper gives an overview of sea surface temperature (SST) activities at EUMETSAT including information on SST planned from the Sea and Land Surface Temperature Radiometer (SLSTR). Operational oceanography activities within the Marine Applications group at EUMETSAT continue with a focus on SST, sea surface winds, sea-ice products, radiative fluxes, significant wave height and sea surface topography. These are achieved through the mandatory, optional and third-party programmes, and for some products with the EUMETSAT Ocean and Sea-Ice Satellite Application Facility (OSI SAF). Progress towards products from sea-ice surface temperature, ocean colour products, turbidity and aerosol optical depth over water continue. Information on oceanography products from EUMETSAT can be found through the product navigator (http://navigator.eumetsat.int). EUMETSAT have been collaborating with ESA for a number of years on the development of SST for SLSTR.

  12. Linearizing neutrino evolution equations including neutrino-antineutrino pairing correlations

    CERN Document Server

    Väänänen, D

    2013-01-01

    We linearize the neutrino mean-field evolution equations describing the neutrino propagation in a background of matter and of neutrinos, using techniques from many-body microscopic approaches. The procedure leads to an eigenvalue equation that allows to identify instabilities in the evolution, associated with a change of the curvature of the neutrino energy-density surface. Our result includes all contributions from the neutrino Hamiltonian and is generalizable to linearize the equations of motion at an arbitrary point of the evolution. We then consider the extended equations that comprise the normal mean field as well as the abnormal mean field that is associated with neutrino-antineutrino pairing correlations. We first re-derive the extended neutrino Hamiltonian and show that such a Hamiltonian can be diagonalized by introducing a generalized Bogoliubov transformation with quasi-particle operators that mix neutrinos and antineutrinos. We give the eigenvalue equations that determine the energies of the quasi...

  13. Floating-point systolic array including serial processors

    Energy Technology Data Exchange (ETDEWEB)

    Leeland, S.B.

    1989-10-03

    This patent describes, in a systolic array system utilizing a plurality of semiconductor chips, a semiconductor chip. It comprises: a plurality of processing elements each including a floating-point serial processor and a plurality of data storage registers; global bus means coupled to the serial processor of each of the plurality of processing elements for inputing and outputing data to and from each chip and for programming each serial processor; and a plurality of data buses coupled to each of the plurality of data storage registers of each of the plurality of processing elements. The global bus means being coupled to the plurality of data storage registers for programming the data storage registers.

  14. Goldilocks Models of Higher-Dimensional Inflation (including modulus stabilization)

    CERN Document Server

    Burgess, C P; Hayman, Peter; Patil, Subodh P

    2016-01-01

    We explore the mechanics of inflation in simplified extra-dimensional models involving an inflaton interacting with the Einstein-Maxwell system in two extra dimensions. The models are Goldilocks-like in that they are just complicated enough to include a mechanism to stabilize the extra-dimensional size, yet simple enough to solve the full 6D field equations using basic tools. The solutions are not limited to the effective 4D regime with H m_KK, but when they do standard 4D fluctuation calculations need not apply. When in a 4D regime the solutions predict eta ~ 0 hence n_s ~ 0.96 and r ~ 0.096 and so are ruled out if tensor modes remain unseen. Analysis of general parameters is difficult without a full 6D fluctuation calculation.

  15. Gravitational solutions, including radiation, for a perturbed light beam

    Energy Technology Data Exchange (ETDEWEB)

    Nackoney, R.W.

    1986-09-01

    Linearized field equations and solutions are derived for a perturbed sheet beam of light. The work is based on an exact solution of a collimated beam in the geometrical limit. The linearized field changes of the initially curved background metric can be put, with the help of the harmonic conditions, into a normal coordinate form. These six normal coordinates satisfy six linearized, inhomogeneous, field equations in three variables. Stationary solutions include divergent beams. Gravitational waves propagating opposite to the beam's flux are found to be confined to a region about the propagation axis of the beam, much as is experienced in wave guides. Radiative cases can be produced by large angle scattering of light and are discussed in terms of their effect on an ideal optical antenna. The effect is one that grows linearly with time. The growth time is prohibitively long for the most energetic systems that can be realistically considered in the foreseeable future.

  16. Loan Products Included in the Offer of Commercial Banks

    Directory of Open Access Journals (Sweden)

    Vasile Dedu

    2009-04-01

    Full Text Available A bank loan is the main form of economical credit. It is for corporate activities – for medium and big companies and for retail activities – for small companies and individuals. The conditions for credit mainly depend on the quality of customers, it means their ability to perform a profitable activity and to be able to pay back the credits. For reasons which are mainly connected to marketing, bank practice has developed a large range of credit names, trying to emphasize some of the parts of the products or to take profit of some competition advantages in relation with customers’ products. We are trying to include the offer of bank loans in a typology which takes into account the law, the bank field rules and the main technical features of the offered products.

  17. Dynamic Analysis of Wind Turbines Including Soil-Structure Interaction

    DEFF Research Database (Denmark)

    Harte, M.; Basu, B.; Nielsen, Søren R.K.

    2012-01-01

    This paper investigates the along-wind forced vibration response of an onshore wind turbine. The study includes the dynamic interaction effects between the foundation and the underlying soil, as softer soils can influence the dynamic response of wind turbines. A Multi-Degree-of-Freedom (MDOF...... rotational speed (3P effects). The effect of dynamic soil-structure interaction on the rotation of the foundation has also been investigated.......) horizontal axes onshore wind turbine model is developed for dynamic analysis using an Euler–Lagrangian approach. The model is comprised of a rotor blade system, a nacelle and a flexible tower connected to a foundation system using a substructuring approach. The rotor blade system consists of three rotating...

  18. The physics of semiconductors an introduction including nanophysics and applications

    CERN Document Server

    Grundmann, Marius

    2016-01-01

    The 3rd edition of this successful textbook contains ample material for a comprehensive upper-level undergraduate or beginning graduate course, guiding readers to the point where they can choose a special topic and begin supervised research. The textbook provides a balance between essential aspects of solid-state and semiconductor physics, on the one hand, and the principles of various semiconductor devices and their applications in electronic and photonic devices, on the other. It highlights many practical aspects of semiconductors such as alloys, strain, heterostructures, nanostructures, that are necessary in modern semiconductor research but typically omitted in textbooks. Coverage also includes additional advanced topics, such as Bragg mirrors, resonators, polarized and magnetic semiconductors, nanowires, quantum dots, multi-junction solar cells, thin film transistors, carbon-based nanostructures and transparent conductive oxides. The text derives explicit formulas for many results to support better under...

  19. Molecular phylogeny of coronaviruses including human SARS-CoV

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Phylogenetic tree of coronaviruses (CoVs) including the human SARS-associated virus is reconstructed from complete genomes by using our newly developed K- string composition approach. The relation of the human SARS-CoV to other coronaviruses, i.e. the rooting of the tree is suggested by choosing an appropriate outgroup. SARS-CoV makes a separate group closer but still distant from G2 (CoVs in mammalian host). The relation between different isolates of the human SARS virus is inferred by first constructing an ultrametric distance matrix from counting sequence variations in the genomes. The resulting tree is consistent with clinic relations between the SARS-CoV isolates. In addition to a larger variety of coronavirus genomes these results provide phylogenetic knowledge based on independent novel methodology as compared to recent phylogenetic studies on SARS-CoV.

  20. Oscillatory burning of solid propellants including gas phase time lag.

    Science.gov (United States)

    T'Ien, J. S.

    1972-01-01

    An analysis has been performed for oscillatory burning of solid propellants including gas phase time lag. The gaseous flame is assumed to be premixed and laminar with a one-step overall chemical reaction. The propellant is assumed to decompose according to the Arrenhius Law, with no condensed phase reaction. With this model, strong gas phase resonance has been found in certain cases at the characteristic gas-phase frequencies, but the peaking of the acoustic admittance is in the direction favoring the damping of pressure waves. At still higher frequencies, moderate wave-amplifying ability was found. The limit of low frequency response obtained previously by Denison and Baum was recovered, and the limitations of the quasi-steady theory were investigated.

  1. Precision Obesity Treatments Including Pharmacogenetic and Nutrigenetic Approaches.

    Science.gov (United States)

    Solas, Maite; Milagro, Fermin I; Martínez-Urbistondo, Diego; Ramirez, Maria J; Martínez, J Alfredo

    2016-07-01

    Five pharmaceutical strategies are currently approved by the US FDA for the treatment of obesity: orlistat, lorcaserin, liraglutide, phentermine/topiramate, and bupropion/naltrexone. The most effective treatment seems to be the combined administration of phentermine/topiramate followed by lorcaserin and bupropion/naltrexone. In relation to the management of excessive weight, other aspects also need to be considered, including comorbidities accompanying obesity, drug interactions, and the risk of negative collateral effects, as well as individualized treatments based on the genetic make-up. This review aims to provide an overview of the approved anti-obesity drugs and newer molecules that could affect different targets in the central nervous system or peripheral tissues, the molecular mechanisms, emerging dietary treatments and phytogenic compounds, and pharmacogenetic/nutrigenetic approaches for personalized obesity management.

  2. Thermodynamic analysis of a Stirling engine including regenerator dead volume

    Energy Technology Data Exchange (ETDEWEB)

    Puech, Pascal; Tishkova, Victoria [Universite de Toulouse, UPS, CNRS, CEMES, 29 rue Jeanne Marvig, F-31055 Toulouse (France)

    2011-02-15

    This paper provides a theoretical investigation on the thermodynamic analysis of a Stirling engine with linear and sinusoidal variations of the volume. The regenerator in a Stirling engine is an internal heat exchanger allowing to reach high efficiency. We used an isothermal model to analyse the net work and the heat stored in the regenerator during a complete cycle. We show that the engine efficiency with perfect regeneration doesn't depend on the regenerator dead volume but this dead volume strongly amplifies the imperfect regeneration effect. An analytical expression to estimate the improvement due to the regenerator has been proposed including the combined effects of dead volume and imperfect regeneration. This could be used at the very preliminary stage of the engine design process. (author)

  3. Hydraulic engine valve actuation system including independent feedback control

    Science.gov (United States)

    Marriott, Craig D

    2013-06-04

    A hydraulic valve actuation assembly may include a housing, a piston, a supply control valve, a closing control valve, and an opening control valve. The housing may define a first fluid chamber, a second fluid chamber, and a third fluid chamber. The piston may be axially secured to an engine valve and located within the first, second and third fluid chambers. The supply control valve may control a hydraulic fluid supply to the piston. The closing control valve may be located between the supply control valve and the second fluid chamber and may control fluid flow from the second fluid chamber to the supply control valve. The opening control valve may be located between the supply control valve and the second fluid chamber and may control fluid flow from the supply control valve to the second fluid chamber.

  4. Optimising the composition of natural moulding sands including thermal aspects

    Directory of Open Access Journals (Sweden)

    Jerzy St. Kowalski

    2011-04-01

    Full Text Available The paper discusses the problem of the choice of the moulding sand mixture composition in terms of the sand behaviour in contact withmolten metal. Studies of high-temperature phenomena make assessment of the sand composition applicability under real operatingconditions possible, thus leading to the elimination of sand-originating casting defects. The research was conducted on selected moulding materials included in the composition of traditional moulding sand mixtures without the addition of carbon. The effect of moulding sand composition and moisture content on the linear dilatation and stress-induced allotropic changes of quartz was examined. The analysis of these phenomena was based on 3D charts and maps generated from data collected during the tests.

  5. The action principle for generalized fluid motion including gyroviscosity

    Energy Technology Data Exchange (ETDEWEB)

    Lingam, M., E-mail: manasvi@physics.utexas.edu; Morrison, P.J., E-mail: morrison@physics.utexas.edu

    2014-11-07

    Highlights: • Method for constructing action principles for a diverse class of fluids with gyroscopic momentum transport is described. • General criteria for the conservation of momentum and angular momentum via Noether's theorem are obtained. • Fluids with intrinsic angular momentum are built as an illustration of the method. - Abstract: A general set of fluid equations that allow for energy-conserving momentum transport by gyroscopic motion of fluid elements is obtained. The equations are produced by a class of action principles that yield a large subset of the known fluid and magnetofluid models, including gyroviscosity. Analysis of the action principle yields broad, model-independent results regarding the conservation laws of energy and linear and angular momenta. The formalism is illustrated by studying fluid models with intrinsic angular momentum that may appear in the contexts of condensed matter, biological, and other areas of physics.

  6. A model of Barchan dunes including lateral shear stress.

    Science.gov (United States)

    Schwämmle, V; Herrmann, H J

    2005-01-01

    Barchan dunes are found where sand availability is low and wind direction quite constant. The two dimensional shear stress of the wind field and the sand movement by saltation and avalanches over a barchan dune are simulated. The model with one dimensional shear stress is extended including surface diffusion and lateral shear stress. The resulting final shape is compared to the results of the model with a one dimensional shear stress and confirmed by comparison to measurements. We found agreement and improvements with respect to the model with one dimensional shear stress. Additionally, a characteristic edge at the center of the windward side is discovered which is also observed for big barchans. Diffusion effects reduce this effect for small dunes.

  7. About meanings as a rule not included in dictionaries

    Directory of Open Access Journals (Sweden)

    Violetta Koseska-Toszewa

    2015-11-01

    Full Text Available About meanings as a rule not included in dictionaries The article discusses the problem of ambiguity of the exponents of logical existential quantification occurring in the verbal group of Bulgarian, Polish and Russian sentences: Bulg. отвреме навреме, понякога, Pol. od czasu do czasu, czasem, czasami, Rus. время от времени, иногда. This ambiguity can be explained by strong and weak existential quantification. Lexical semantics did not distinguish between these two types of existentiality. Here we present a description of selected exponents of logical existential quantification in Bulgarian, Polish and Russian.

  8. Numerical Modeling of Electroacoustic Logging Including Joule Heating

    Science.gov (United States)

    Plyushchenkov, Boris D.; Nikitin, Anatoly A.; Turchaninov, Victor I.

    It is well known that electromagnetic field excites acoustic wave in a porous elastic medium saturated with fluid electrolyte due to electrokinetic conversion effect. Pride's equations describing this process are written in isothermal approximation. Update of these equations, which allows to take influence of Joule heating on acoustic waves propagation into account, is proposed here. This update includes terms describing the initiation of additional acoustic waves excited by thermoelastic stresses and the heat conduction equation with right side defined by Joule heating. Results of numerical modeling of several problems of propagation of acoustic waves excited by an electric field source with and without consideration of Joule heating effect in their statements are presented. From these results, it follows that influence of Joule heating should be taken into account at the numerical simulation of electroacoustic logging and at the interpretation of its log data.

  9. The Physics of Semiconductors An Introduction Including Nanophysics and Applications

    CERN Document Server

    Grundmann, Marius

    2010-01-01

    The Physics of Semiconductors contains ample material for a comprehensive upper-level undergraduate or beginning graduate course, guiding readers to the point where they can choose a special topic and begin supervised research. The textbook provides a balance between essential aspects of solid-state and semiconductor physics, on the one hand, and the principles of various semiconductor devices and their applications in electronic and photonic devices, on the other. It highlights many practical aspects of semiconductors such as alloys, strain, heterostructures, nanostructures, that are necessary in modern semiconductor research but typically omitted in textbooks. Coverage also includes additional advanced topics, such as Bragg mirrors, resonators, polarized and magnetic semiconductors. The text derives explicit formulas for many results to support better understanding of the topics. The Physics of Semiconductors requires little or no prior knowledge of solid-state physics and evolved from a highly regarded two...

  10. Traversing Cosmological Singularities, Complete Journeys Through Spacetime Including Antigravity

    CERN Document Server

    Bars, Itzhak

    2012-01-01

    A unique description of the Big Crunch-Big Bang transition is given at the classical gravity level, along with a complete set of homogeneous, isotropic, analytic solutions in scalar-tensor cosmology, with radiation and curvature. All solutions repeat cyclically; they have been obtained by using conformal gauge symmetry (Weyl symmetry) as a powerful tool in cosmology, and more generally in gravity. The significance of the Big Crunch-Big Bang transition is that it provides a model independent analytic resolution of the singularity, as an unambiguous and unavoidable solution of the equations at the classical gravitational physics level. It is controlled only by geometry (including anisotropy) and only very general features of matter coupled to gravity, such as kinetic energy of a scalar field, and radiation due to all forms of relativistic matter. This analytic resolution of the singularity is due to an attractor mechanism created by the leading terms in the cosmological equation. It is unique, and it is unavoid...

  11. A Case for Including Transactions in OpenMP

    Energy Technology Data Exchange (ETDEWEB)

    Wong, M; Bihari, B L; de Supinski, B R; Wu, P; Michael, M; Liu, Y; Chen, W

    2010-01-25

    Transactional Memory (TM) has received significant attention recently as a mechanism to reduce the complexity of shared memory programming. We explore the potential of TM to improve OpenMP applications. We combine a software TM (STM) system to support transactions with an OpenMP implementation to start thread teams and provide task and loop-level parallelization. We apply this system to two application scenarios that reflect realistic TM use cases. Our results with this system demonstrate that even with the relatively high overheads of STM, transactions can outperform OpenMP critical sections by 10%. Overall, our study demonstrates that extending OpenMP to include transactions would ease programming effort while allowing improved performance.

  12. Fuel cell repeater unit including frame and separator plate

    Energy Technology Data Exchange (ETDEWEB)

    Yamanis, Jean; Hawkes, Justin R; Chiapetta, Jr., Louis; Bird, Connie E; Sun, Ellen Y; Croteau, Paul F

    2013-11-05

    An example fuel cell repeater includes a separator plate and a frame establishing at least a portion of a flow path that is operative to communicate fuel to or from at least one fuel cell held by the frame relative to the separator plate. The flow path has a perimeter and any fuel within the perimeter flow across the at least one fuel cell in a first direction. The separator plate, the frame, or both establish at least one conduit positioned outside the flow path perimeter. The conduit is outside of the flow path perimeter and is configured to direct flow in a second, different direction. The conduit is fluidly coupled with the flow path.

  13. Relativistic bound state approach to fundamental forces including gravitation

    Directory of Open Access Journals (Sweden)

    Morsch H.P.

    2012-06-01

    Full Text Available To describe the structure of particle bound states of nature, a relativistic bound state formalism is presented, which requires a Lagrangian including scalar coupling of two boson fields. The underlying mechanisms are quite complex and require an interplay of overlapping boson fields and fermion-antifermion production. This gives rise to two potentials, a boson-exchange potential and one identified with the long sought confinement potential in hadrons. With minimal requirements, two elementary massless fermions (quantons - with and without charge - and one gauge boson, hadrons and leptons but also atoms and gravitational systems are described by bound states with electric and magnetic coupling between the charges and spins of quantons. No need is found for colour, Higgs-coupling and supersymmetry.

  14. CHIONANTHUS (OLEACEAE IN SULAWESI, INDONESIA, INCLUDING THREE NEW SPECIES

    Directory of Open Access Journals (Sweden)

    RUTH KIEW

    2016-01-01

    Full Text Available KIEW, R. 2015. Chionanthus (Oleaceae in Sulawesi, Indonesia, including three new species. Reinwardtia 14(2: 287 ‒295. ― The genus Chionanthus (Oleaceae in Sulawesi is revised. Nine species are described of which C. kostermansiiKiew, C. sordidus Kiew and C. sulawesicus Kiew are new species. Four species are endemic, C. celebicus Koord., C.sordidus, C. stenurus (Merr. Kiew and C. sulawesicus. The geographic range of C. cordulatus Koord. extends to Borneoand Mollucas, while C. kostermansii also occurs in Sumbawa and Flores, and the range of C. rupicolus (Lingelsh.Kiew extends to Sumbawa, Mollucas, New Guinea and the Bismarck Archipelago. Chionanthus polygamus (Roxb.Kiew and C. ramiflorus Roxb. are both widespread species, the former from Sumatra to New Guinea and the latter fromcontinental Asia to the Solomon Islands. A key to identify the species is provided. Chionanthus gigantifolius Koord.remains incompletely known.

  15. Improving Planck calibration by including frequency-dependent relativistic corrections

    CERN Document Server

    Quartin, Miguel

    2015-01-01

    The Planck satellite detectors are calibrated in the 2015 release using the "orbital dipole", which is the time-dependent dipole generated by the Doppler effect due to the motion of the satellite around the Sun. Such an effect has also relativistic time-dependent corrections of relative magnitude 10^(-3), due to coupling with the "solar dipole" (the motion of the Sun compared to the CMB rest frame), which are included in the data calibration by the Planck collaboration. We point out that such corrections are subject to a frequency-dependent multiplicative factor. This factor differs from unity especially at the highest frequencies, relevant for the HFI instrument. Since currently Planck calibration errors are dominated by systematics, to the point that polarization data is currently unreliable at large scales, such a correction can in principle be highly relevant for future data releases.

  16. Improving Planck calibration by including frequency-dependent relativistic corrections

    Science.gov (United States)

    Quartin, Miguel; Notari, Alessio

    2015-09-01

    The Planck satellite detectors are calibrated in the 2015 release using the "orbital dipole", which is the time-dependent dipole generated by the Doppler effect due to the motion of the satellite around the Sun. Such an effect has also relativistic time-dependent corrections of relative magnitude 10-3, due to coupling with the "solar dipole" (the motion of the Sun compared to the CMB rest frame), which are included in the data calibration by the Planck collaboration. We point out that such corrections are subject to a frequency-dependent multiplicative factor. This factor differs from unity especially at the highest frequencies, relevant for the HFI instrument. Since currently Planck calibration errors are dominated by systematics, to the point that polarization data is currently unreliable at large scales, such a correction can in principle be highly relevant for future data releases.

  17. Oscillatory burning of solid propellants including gas phase time lag.

    Science.gov (United States)

    T'Ien, J. S.

    1972-01-01

    An analysis has been performed for oscillatory burning of solid propellants including gas phase time lag. The gaseous flame is assumed to be premixed and laminar with a one-step overall chemical reaction. The propellant is assumed to decompose according to the Arrenhius Law, with no condensed phase reaction. With this model, strong gas phase resonance has been found in certain cases at the characteristic gas-phase frequencies, but the peaking of the acoustic admittance is in the direction favoring the damping of pressure waves. At still higher frequencies, moderate wave-amplifying ability was found. The limit of low frequency response obtained previously by Denison and Baum was recovered, and the limitations of the quasi-steady theory were investigated.

  18. Preferential Biases for Texts That Include Neuroscientific Jargon.

    Science.gov (United States)

    Tabacchi, Marco E; Cardaci, Maurizio

    2016-06-01

    The results of an experiment of preferential biases for texts that include neuroscientific jargon are presented. Such preferential bias has been reported even when the presented jargon is meaningless. In a variation of the well-known Weisberg et al. experiment, a group of undergraduate students (N = 150; females 48%, males 52%, other 0%; M age = 22.4 year, SD = 2.6) chose between two possible explanations for a psychological phenomenon: a correct explanation or a circular restatement of facts. Unrelated neuroscientific terms were added to one of the explanations. Participants were asked to choose the correct explanation. There was a statistically significant preference for the explanation without neuroscientific terms. These findings differ from Weisberg et al.'s experiment and a number of others. The implications of this discrepancy are discussed.

  19. Parabasal theory for plane-symmetric systems including freeform surfaces

    Science.gov (United States)

    Abd El-Maksoud, Rania H.; Hillenbrand, Matthias; Sinzinger, Stefan

    2014-03-01

    An extension of paraxial theory to systems with a single plane of symmetry is provided. This parabasal model is based on the evaluation of a differential region around the reference ray that is defined by the center of the object and the center of the stop. To include freeform surfaces in this model, the local curvatures at the intersection point of the reference ray and the surface are evaluated. As an application, a generalized Scheimpflug principle is presented. The validity of the derived formulas is tested for highly tilted surfaces and is in good agreement with the exact ray tracing results. The analytical expressions are used to provide a first-order layout design of a planar imaging system.

  20. Ball Screw Actuator Including a Compliant Ball Screw Stop

    Science.gov (United States)

    Wingett, Paul T. (Inventor); Hanlon, Casey (Inventor)

    2017-01-01

    An actuator includes a ball nut, a ball screw, and a ball screw stop. The ball nut is adapted to receive an input torque and in response rotates and supplies a drive force. The ball screw extends through the ball nut and has a first end and a second end. The ball screw receives the drive force from the ball nut and in response selectively translates between a retract position and a extend position. The ball screw stop is mounted on the ball screw proximate the first end to translate therewith. The ball screw stop engages the ball nut when the ball screw is in the extend position, translates, with compliance, a predetermined distance toward the first end upon engaging the ball nut, and prevents further rotation of the ball screw upon translating the predetermined distance.