WorldWideScience

Sample records for sanger unified school

  1. Unified School Districts, Census 2000

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — The New Mexico 2000 Unified School Districts layer was derived from the TIGER Line files from the US Census Bureau. The districts are clipped to the state...

  2. Margaret Sanger

    Institute of Scientific and Technical Information of China (English)

    吴伟华

    2005-01-01

    Many women today have the freedom to decide when they will have children, if they want them. Until aboutfifty years ago, women spent most of their adultlives having children,year after year. This changed because of efforts by activists like Margaret Sanger. She believed that a safe and sure method of preventing pregnancy was a necessary condition for women's freedom. She also believed birth control was necessary for human progress.

  3. A Unifying Curriculum for Museum-Schools

    Science.gov (United States)

    Povis, Kaleen E.

    2011-01-01

    There are over two dozen schools in the United States with the word "museum" in their names. However, the philosophy and pedagogy that tie these schools together is unclear. A consistent definition, criteria for classification, and a unifying curriculum to guide museum- schools is lacking. Yet, museum-schools continue to open across the country.…

  4. Integration Defended: Berkeley Unified's Strategy to Maintain School Diversity

    Science.gov (United States)

    Chavez, Lisa; Frankenberg, Erica

    2009-01-01

    In June 2007, the Supreme Court limited the tools that school districts could use to voluntarily integrate schools. In the aftermath of the decision, educators around the country have sought models of successful plans that would also be legal. One such model may be Berkeley Unified School District's (BUSD) plan. Earlier this year, the California…

  5. Was Margaret Sanger a racist?

    Science.gov (United States)

    Valenza, C

    1985-01-01

    Margaret Sanger, as a young public health nurse, witnessed the sickness, disease and poverty caused by unwanted pregnancies. She spent the rest of her life trying to alleviate these conditions by bringing birth control to America. During the early 20th century, the idea of making contraceptives generally available was revolutionary. Contraceptive usage was considered a distinguishing feature of the 'haves.' In recent years, some revisionist biographers have portrayed Sanger as a eugenicist and a racist. This view has been widely publicized by critics of reproductive rights who have attempted to discredit Sanger's work by discrediting her personally. The basic concept of the eugenics movement in the 1920s and 1930s was that a better breed of humans would be created if the 'fit' had more children and the 'unfit' had fewer. This concept influenced a broad spectrum of thought, but there was little consensus on the definitions of fit and unfit. In theory, the movement was not racist--its message intended to cross race barriers for the overall advancement of mankind. Most eugenicists agreed that birth control would be a detriment to the human race and were opposed to it. Charges that Sanger's motives for promoting birth control were eugenic are not supported. In part of her most important work, "Pivot of Civilization," Sanger's dissent from eugenics was made clear. By examining extracts from her books, the author refutes the notion that Sanger was a eugenicist. Another unsupported argument raised by the anti-Sanger group was that Sanger, in her position as editor of "Birth Contol Review," published eugenicists' views. It would be more accurate to say that the review covered a wide range of opinions and research; the eugenicists views were included because they conferred respectability. David Kennedy, author of "Birth Control in America," does Sanger a grave injustice by falsely attributing to her the quotation: 'More children from the fit, less from the unfit--that is

  6. Unified Discipline: A School-Wide Approach for Managing Problem Behavior.

    Science.gov (United States)

    White, Richard; Algozzine, Bob; Audette, Robert; Marr, Mary Beth; Ellis, Edward D., Jr.

    2001-01-01

    This article explains how to implement "unified discipline" as a school-wide approach to managing problem behavior, an approach designed to support educators in meeting the needs of students with emotional and behavioral problems in general education classrooms by establishing unified attitudes, expectations, correction procedures, and team roles.…

  7. Strategic Plan for Sustainable Energy Management and Environmental Stewardship for Los Angeles Unified School District

    Energy Technology Data Exchange (ETDEWEB)

    Walker, A.; Beattie, D.; Thomas, K.; Davis, K.; Sim, M.; Jhaveri, A.

    2007-11-01

    This Strategic Plan for Sustainable Energy Management and Environmental Stewardship states goals, measures progress toward goals and how actions are monitored to achieve continuous improvement for the Los Angeles Unified School District.

  8. Grades 1-8, Apache Junction Unified School District 43, Apache Junction, Arizona. PLATO Evaluation Series.

    Science.gov (United States)

    Quinn, David W.; Quinn, Nancy W.

    Apache Junction Unified School District, Arizona, has embarked on a 5-year program of instructional improvement using technology. PLATO Elementary reading and mathematics products were installed in the district's elementary and middle schools at the beginning of the 1999-2000 school year. This evaluation studied the use and preliminary student…

  9. Genetic Testing Requires NGS and Sanger Methodologies.

    Science.gov (United States)

    Jennings, Lawrence J; Kirschmann, Dawn

    2016-09-01

    Investigators from the EuroEPINOMICS rare epilepsy syndromes Dravet working group performed whole-exome sequencing on 31 trios that had been reported negative for SCN1A mutations by Sanger sequencing.

  10. Project Support Evaluation, Los Angeles Unified School District. Report No. 1.

    Science.gov (United States)

    Slovacek, Simeon P.; And Others

    This report describes the first operating year of Project Support, a 3-year gang/drug prevention program aimed at elementary students in six inner city schools in the Los Angeles Unified School District. The project involves the implementation of nine strategies described in the research literature as being effective in drug/gang prevention. These…

  11. A K-12 Articulation Model for the Orange Unified School District.

    Science.gov (United States)

    Joseph, Louie S.

    This Maxi II practicum documents the development of a model articulation process and the implementation of that process in the Orange (California) Unified School District. The model was intended to improve the continuity of student progression through the grades from elementary to junior high to senior high school. Primary concerns of the…

  12. New Dots Downunder: The Implementation of Unified English Braille (UEB) in Australian Schools

    Science.gov (United States)

    Gentle, Frances; Steer, Michael; Howse, Josie

    2012-01-01

    In this article the authors will outline and describe the recent implementation of Unified English Braille (UEB) in Australia's complex school systems. The New South Wales Department of Education and Communities (NSW/DEC) played a leading role in the process. The education sector at all levels in Australia appears to have embraced the introduction…

  13. Conejo Valley Unified School District Master Plan for an Educational Results Information System.

    Science.gov (United States)

    Maloney, Dorothy

    The Conejo Valley (CA) Unified School District Educational Results Information System (ERIS), a generalized District master program assessment plan to obtain results information for decision-makers at all levels, has been developed. This plan establishes guidelines, evaluates the current status of the use of educational results information and…

  14. Conejo Valley Unified School District Master Plan for an Educational Results Information System.

    Science.gov (United States)

    Maloney, Dorothy

    The Conejo Valley (CA) Unified School District Educational Results Information System (ERIS), a generalized District master program assessment plan to obtain results information for decision-makers at all levels, has been developed. This plan establishes guidelines, evaluates the current status of the use of educational results information and…

  15. Censored and Censured: Racine Unified School District vs. Wisconsin Library Association.

    Science.gov (United States)

    Tollefson, Alan M.

    1987-01-01

    Describes the censure of the Racine Unified School District by the Wisconsin Library Association for its internal censorship of library materials. Highlights include a chronology of events in the case, the district's history of censorship, its selection policy, and the importance of the case as a model. (EM)

  16. Parents Rights: The Case for Madera Unified School District

    Science.gov (United States)

    Padilla, Frank

    2009-01-01

    The purpose of this article is to identify power through voting-school boards; it must be explicitly identified and highlighted as a way to empower students and their families. Implications for teachers are discussed, as their role in public schools is crucial to improved parent participation. It examines how Latino parents have used the justice…

  17. Parents Rights: The Case for Madera Unified School District

    Science.gov (United States)

    Padilla, Frank

    2009-01-01

    The purpose of this article is to identify power through voting-school boards; it must be explicitly identified and highlighted as a way to empower students and their families. Implications for teachers are discussed, as their role in public schools is crucial to improved parent participation. It examines how Latino parents have used the justice…

  18. Sunnyside Unified School District No. 12 Bilingual Program Guide.

    Science.gov (United States)

    Allison, Isabel Ronquillo; And Others

    This program manual is for a four-school elementary bilingual education program in Tucson that aims at developing proficiency in the basic skills of the native language and transferring these skills to the second language. The following information is included in narrative and outline form: (1) goals; (2) program description; (3) overview of…

  19. School Districts, Unified School Districts Within Phillips County, Published in 2008, 1:4800 (1in=400ft) scale, Phillips County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This School Districts dataset, published at 1:4800 (1in=400ft) scale, was produced all or in part from Other information as of 2008. It is described as 'Unified...

  20. Improving Ethnic Balance and Intergroup Relations; An Advisory Report to the Board of Education, Corona Unified School Districts.

    Science.gov (United States)

    California State Dept. of Education, Sacramento. Bureau of Intergroup Relations.

    This report contains the findings of a field study of the ethnic and racial composition and intergroup relations in the schools in the Corona Unified School District, California. These findings are information on (1) the district's approaches to desegregation and its policy on intergroup relations, (2) students' achievement differences, (3)…

  1. A Tale of Two Districts: A Comparative Study of Student-Based Funding and School-Based Decision Making in San Francisco and Oakland Unified School Districts

    Science.gov (United States)

    Chambers, Jay; Shambaugh, Larisa; Levin, Jesse; Muraki, Mari; Poland, Lindsay

    2008-01-01

    Though the number of districts with student-based funding-type (SBF) policies has grown, the literature on the implementation and possible impacts of these policies is limited. To address this, this report describes the implementation of SBF policies in two California school districts--San Francisco Unified School District and Oakland Unified…

  2. Pyrosequencing-An Alternative to Traditional Sanger Sequencing

    OpenAIRE

    2012-01-01

    Problem statement: Pyrosequencing has the potential to rapidly and reliably sequence DNA taking advantages over traditional Sanger di-deoxy sequencing approach. Approach: A comprehensive review of the literature on the principles, applications, challenges and prospects of pyrosequencing was performed. Results: Pyrosequencing was a DNA sequencing technology based on the sequencing-by-synthesis principle. It employs a series of four enzymes to accurately detect nucleic acid sequences during the...

  3. Evaluation of English Language Development Programs in the Santa Ana Unified School District. A Report on Data System Reliability and Statistical Modeling of Program Impacts.

    Science.gov (United States)

    Mitchell, Douglas E.; Destino, Tom; Karam, Rita

    In response to concern about the effectiveness of programs for English-as-a-Second-Language students in California's schools, the Santa Ana Unified School District, in which over 80 percent of students are limited-English-proficient (LEP) conducted a study of both the operations and effectiveness of the district's language development program,…

  4. Evaluation of the Knowledge Level of High School Students in the João Pessoa City with Visual Impairment About Unified Chemistry and Mathematics Braille Code

    Directory of Open Access Journals (Sweden)

    João Batista M. de Resende Filho

    2013-06-01

    Full Text Available The Braille Code is very important in the educational process of students with visual impairment, because this writing system allows which the students know the systematic and organized writing knowledge. These students need to know the symbols and the use’s standards of them, so they can write, read and understand the contents. The Unified Chemistry and Mathematics Braille Code are fundamentally important for these students to understand the texts about these themes. This study aimed to evaluation of the knowledge level of High School students with visual impairment in the João Pessoa city about Unified Chemistry and Mathematics Braille Code. The students showed a relatively good knowledge of symbols and rules of the Unified Mathematics Braille Code, presenting, in the most cases, difficulties in recognizing unusual symbols. The student’s main difficulties were related to Unified Chemistry Braille Code, because they did not know many symbols and writing rules, presenting a low knowledge level.

  5. Build a Creative Leadership Team: Take a Unified Approach to Fostering Arts Education in Your School

    Science.gov (United States)

    Principal, 2012

    2012-01-01

    Becoming a champion of arts education means establishing a culture that embraces a team approach toward integrating the arts. This article offers some practical guidance for developing a creative leadership team--and cultivating creativity in the whole school.

  6. Turning the Curve on Obesity Prevalence Among Fifth Graders in the Los Angeles Unified School District, 2001–2013

    Science.gov (United States)

    Hameed, Heena; Shih, Margaret; Simon, Paul

    2017-01-01

    Introduction After multiple decades of increasing childhood obesity prevalence in the United States, findings from recent studies suggest that prevalence has leveled or is decreasing in some populations. However, demographic and socioeconomic disparities in prevalence remain and may be increasing. Methods To assess recent trends and disparities in childhood obesity prevalence in Los Angeles County, we analyzed data from 2001 through 2013 in fifth graders in the Los Angeles Unified School District (LAUSD). Obesity was defined as a body mass index at or above the 95th percentile for children of the same age and sex as compared with Centers for Disease Control and Prevention growth charts, on the basis of measured height and weight. Trends were examined by sex, race/ethnicity, and socioeconomic status (SES). SES was determined by using school-level data on the percentage of students participating in a free and reduced-price meal program. Results Obesity prevalence increased from 27.5% in 2001 to 31.6% in 2005, was stable from 2005 through 2010, and decreased from 31.6% in 2010 to 28.5% in 2013. Similar trajectories in prevalence were observed for all demographic and SES subgroups, although the decline in prevalence began earlier among whites and students attending schools in the highest SES group. Disparities in prevalence by race/ethnicity and SES were observed during the entire study period but narrowed slightly from 2010 through 2013. Conclusion Although obesity prevalence among fifth graders in LAUSD declined from 2010 through 2013, prevalence remains higher than in 2001, and demographic and socioeconomic disparities in prevalence persist. Future interventions in the county should prioritize Latinos and students attending low SES schools. PMID:28207380

  7. Solar heating and hot water system installed at Southeast of Saline, Unified School District 306, Mentor, Kansas

    Energy Technology Data Exchange (ETDEWEB)

    1979-07-01

    A cooperative agreement was negotiated in April 1978 for the installation of a space and domestic hot water system at Southeast of Saline, Kansas Unified School District 306, Mentor, Kansas. The solar system was installed in a new building and was designed to provide 52 percent of the estimated annual space heating load and 84 percent of the estimated annual potable hot water requirement. The collectors are liquid flat plate. They are ground-mounted and cover a total area of 5125 square feet. The system will provide supplemental heat for the school's closed-loop water-to-air heat pump system and domestic hot water. The storage medium is water inside steel tanks with a capacity of 11,828 gallons for space heating and 1,600 gallons for domestic hot water. This final report, which describes in considerable detail the solar heating facility, contains detailed drawings of the completed system. The facility was declared operational in September 1978, and has functioned successfully since.

  8. Pyrosequencing-An Alternative to Traditional Sanger Sequencing

    Directory of Open Access Journals (Sweden)

    Fakruddin

    2012-01-01

    Full Text Available Problem statement: Pyrosequencing has the potential to rapidly and reliably sequence DNA taking advantages over traditional Sanger di-deoxy sequencing approach. Approach: A comprehensive review of the literature on the principles, applications, challenges and prospects of pyrosequencing was performed. Results: Pyrosequencing was a DNA sequencing technology based on the sequencing-by-synthesis principle. It employs a series of four enzymes to accurately detect nucleic acid sequences during the synthesis. Pyrosequencing had the potential advantages of accuracy, flexibility, parallel processing and could be easily automated. The technique dispenses with the need for labeled primers, labeled nucleotides and gel-electrophoresis. Pyrosequencing had opened up new possibilities for performing sequence-based DNA analysis. The method had been proven highly suitable for single nucleotide polymorphism analysis and sequencing of short stretches of DNA. Pyrosequencing had been successful for both confirmatory sequencing and de novo sequencing. By increasing the read length to higher scores and by shortening the sequence reaction time per base calling, pyrosequencing may take over many broad areas of DNA sequencing applications as the trend was directed to analysis of fewer amounts of specimens and large-scale settings, with higher throughput and lower cost. Conclusion/Recommendations: The Competitiveness of pyrosequencing with other sequencing methods can be improved in future."

  9. Frederick Sanger, Erwin Chargaff, and the metamorphosis of specificity.

    Science.gov (United States)

    Judson, H F

    1993-12-15

    That a transformation of ruling ideas in genetics and biochemistry took place at the dawn of molecular biology, in the late 1940s, is a commonplace; but the nature and components of that transformation are widely misunderstood. The change is often identified with the importation into biology of new styles of thought and new rigor by the many scientists trained in physics or chemistry who came into the nascent field--notably, Max Delbrück, Max Perutz, Francis Crick, John Kendrew, Maurice Wilkins, Rosalind Franklin. Most generally, the change is supposed to be the realization that genes are made not of protein but of nucleic acid--and this change was initiated, of course, by the work of Oswald Avery and his colleagues. These changes are not mutually exclusive, and both were surely important to the genesis of molecular biology. But logically prior to them, more fundamental, was another transformation in ruling preconceptions, one that has been neglected: the revolution in understanding of the chemical structures--the sequences of subunits--of proteins and of nucleic acids which was wrought by the work of Frederick Sanger and of Erwin Chargaff. This was a metamorphosis in the understanding of biochemical specificity, and while it astonished many biochemists it set free the small groups of those who were beginning to call themselves molecular biologists, enabling them to think of the relationship between genes and proteins in entirely new ways.

  10. A Qualitative Multiple-Case Study of the Merger That Formed Twin Rivers Unified School District

    Science.gov (United States)

    Crowe, Christopher Hugh

    2013-01-01

    The history of public education in America is a history of school district mergers. Population growth and improvements in transportation and communication brought isolated communities together. Financial pressures and promises of economies of scale overcame reluctance to merger. In more recent times, federal and state legislation has provided…

  11. Management and Operations Auditing: A Business Oriented Management Structure For a Unified School District.

    Science.gov (United States)

    Conway, Ernest J.; And Others

    An operations audit was conducted for a school district. The purpose of the audit was to determine the organization of the central office and reorganize its structure and staff as appropriate to clearly define goals and objectives, specify roles and responsibilities, eliminate wasted or duplicated efforts, and functionally define operational work…

  12. Educational Planning Information for the Chinle Unified School District No. 24.

    Science.gov (United States)

    Tonigan (Richard F.) and Associates, Ltd., Albuquerque, NM.

    This educational and architectural masterplan prepared for an architectural firm was a major component of the educational reform plan of a remote school system enrolling approximately 3,300 students on the Navajo Reservation in northeastern Arizona. The study found the chronic underfunding of P.L. 81-815, Federal Impact Aid for Indian…

  13. An Examination of Simultaneously Occurring Processes and Outcomes Related to School Closure in One Unified School District in California

    Science.gov (United States)

    Palmer, Christina Jeanne

    2010-01-01

    Neighborhood schools are often the center of their communities; providing an education for students, a meeting place for an assortment of groups, and distribution of information to parents and the public. Notwithstanding their importance, schools often fall victim to downturns in the economy, receiving lower revenues during challenging times.…

  14. The Nation's Report Card Mathematics 2011 Trial Urban District Snapshot Report. Fresno Unified School District. Grade 4, Public Schools

    Science.gov (United States)

    National Center for Education Statistics, 2011

    2011-01-01

    This one-page report presents overall results, achievement level percentages and average score results, scores at selected percentiles, average scores for district and large cities, results for student groups (school race, gender, and eligibility for National School Lunch Program) in 2011, and score gaps for student groups. In 2011, the average…

  15. The Nation's Report Card Reading 2011 Trial Urban District Snapshot Report. Fresno Unified School District. Grade 4, Public Schools

    Science.gov (United States)

    National Center for Education Statistics, 2011

    2011-01-01

    This one-page report presents overall results, achievement level percentages and average score results, scores at selected percentiles, average scores for district and large cities, results for student groups (school race, gender, and eligibility for National School Lunch Program) in 2011, and score gaps for student groups. In 2011, the average…

  16. Electrostatic Potential Maps and Natural Bond Orbital Analysis: Visualization and Conceptualization of Reactivity in Sanger's Reagent

    Science.gov (United States)

    Mottishaw, Jeffery D.; Erck, Adam R.; Kramer, Jordan H.; Sun, Haoran; Koppang, Miles

    2015-01-01

    Frederick Sanger's early work on protein sequencing through the use of colorimetric labeling combined with liquid chromatography involves an important nucleophilic aromatic substitution (S[subscript N]Ar) reaction in which the N-terminus of a protein is tagged with Sanger's reagent. Understanding the inherent differences between this S[subscript…

  17. Automated Sanger Analysis Pipeline (ASAP): A Tool for Rapidly Analyzing Sanger Sequencing Data with Minimum User Interference

    Science.gov (United States)

    Singh, Aditya; Bhatia, Prateek

    2016-01-01

    Sanger sequencing platforms, such as applied biosystems instruments, generate chromatogram files. Generally, for 1 region of a sequence, we use both forward and reverse primers to sequence that area, in that way, we have 2 sequences that need to be aligned and a consensus generated before mutation detection studies. This work is cumbersome and takes time, especially if the gene is large with many exons. Hence, we devised a rapid automated command system to filter, build, and align consensus sequences and also optionally extract exonic regions, translate them in all frames, and perform an amino acid alignment starting from raw sequence data within a very short time. In full capabilities of Automated Mutation Analysis Pipeline (ASAP), it is able to read "*.ab1" chromatogram files through command line interface, convert it to the FASTQ format, trim the low-quality regions, reverse-complement the reverse sequence, create a consensus sequence, extract the exonic regions using a reference exonic sequence, translate the sequence in all frames, and align the nucleic acid and amino acid sequences to reference nucleic acid and amino acid sequences, respectively. All files are created and can be used for further analysis. ASAP is available as Python 3.x executable at https://github.com/aditya-88/ASAP. The version described in this paper is 0.28. PMID:27790076

  18. Hughes, Twain, Child, and Sanger: Four Who Locked Horns with the Censors

    Science.gov (United States)

    Meltzer, Milton

    1969-01-01

    A look at the lives and conflicts of four writers--Langston Hughes, Mark Twain, Lydia Maria Child, and Margaret Sanger--who faced public criticism and censorship because oftheir views on controversial issues. (RM)

  19. The utility of direct specimen detection by Sanger sequencing in hospitalized pediatric patients.

    Science.gov (United States)

    Mongkolrattanothai, Kanokporn; Dien Bard, Jennifer

    2017-02-01

    Direct microbial DNA detection from clinical specimens by polymerase chain reaction and Sanger sequencing has been developed to address the innate limitations of traditional culture-based work-up. We report our institution's experience with direct specimen sequencing, its clinical utility, and barriers to effective clinical implementation.

  20. Targeted next-generation sequencing can replace Sanger sequencing in clinical diagnostics

    NARCIS (Netherlands)

    Sikkema-Raddatz, B.; Johansson, L.F.; de Boer, E.N.; Almomani, R.; Boven, L.G.; van den Berg, M.P.; van Spaendonck-Zwarts, K.Y.; van Tintelen, J.P.; Sijmons, R.H.; Jongbloed, J.D.H.; Sinke, R.J.

    2013-01-01

    Mutation detection through exome sequencing allows simultaneous analysis of all coding sequences of genes. However, it cannot yet replace Sanger sequencing (SS) in diagnostics because of incomplete representation and coverage of exons leading to missing clinically relevant mutations. Targeted next-g

  1. Unifying Abstractions

    DEFF Research Database (Denmark)

    Torgersen, Mads

    of the most complex type relations put forth in type systems research, without compromising such fundamental qualities as conceptuality, modularity and static typing. While many new constructs and unifications are put forth  to substantiate their conceptual validity, type rules are given to support......This thesis presents the RUNE language, a semantic construction of related and tightly coupled programming constructs presented in the shape of a programming language. The major contribution is the succesfull design of a highly unified and general programming model, capable of expressing some...... their typeability and examples are described to demonstrate their use. Novel constructs include a parallel approach to object generation, and a blend of structural and nominal subtyping, while a very general class construct integrates the notions of procedures, parameterisation and genericity, and provides...

  2. Unifying Physics

    Science.gov (United States)

    Goradia, Shantilal

    2013-04-01

    Century old GR fails to unify quantum physics, nuclear force or distinguish between the mass of living bodies from inert mass. Probabilistic gravity [1] explains strong coupling (nuclear force). The natural log of the age of the universe, 10E60 in Planck times, equaling 137 (1/Alpha) extends physics to deeper science, if we stand on the shoulders of giants like Feynman and Gamow. Implications of [1] are that it is not the earth, but M and S numbers of the particles of the earth are remotely interacting with corresponding numbers of the particles of the moon and the sun respectively, neglecting other heavenly bodies in this short draft. This new physics is likely to enable creative scientific minds to throw light on a theoretical basis for an otherwise arbitrary cosmological constant, uniformity of microwave background, further vindication of Boltzmann, quantum informatics, Einstein’s later publicized views and more, eliminating the need to spend money for implicitly nonexistent quantum gravity and graviton.[4pt] [1] Journal of Physical Science and Applications 2 (7) (2012) 265-268.

  3. A Report on the Evaluation of Pilot English Selective Courses in the Mt. Diablo Unified School District.

    Science.gov (United States)

    Gage, Thomas E., Comp.

    This report discusses the results of an evaluation of eleven high school elective, ungraded English courses offered by the Mount Diablo School District in California. The courses were evaluated by classroom teachers and administrators on the basis of modifications of nine of the twelve hypotheses derived from studies by Squire and Applebee…

  4. Online Diagnosis System: a webserver for analysis of Sanger sequencing-based genetic testing data.

    Science.gov (United States)

    Sun, Kun; Yuen, Yuet-Ping; Wang, Huating; Sun, Hao

    2014-10-01

    Sanger sequencing is a well-established molecular technique for diagnosis of genetic diseases. In these tests, DNA sequencers produce vast amounts of data that need to be examined and annotated within a short period of time. To achieve this goal, an online bioinformatics platform that can automate the process is essential. However, to date, there is no such integrated bioinformatics platform available. To fulfill this gap, we developed the Online Diagnosis System (ODS), which is a freely available webserver and supports the commonly used file format of Sanger sequencing data. ODS seamlessly integrates base calling, single nucleotide variation (SNV) identification, and SNV annotation into one single platform. It also allows laboratorians to manually inspect the quality of the identified SNVs in the final report. ODS can significantly reduce the data analysis time therefore allows Sanger sequencing-based genetic testing to be finished in a timely manner. ODS is freely available at http://sunlab.lihs.cuhk.edu.hk/ODS/. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. Evaluating the Efficacy of the High Point Curriculum in the Coastline Unified School District Using CST, CAHSEE, and CELDT Data

    Science.gov (United States)

    Peralta, Aaron A.

    2012-01-01

    The academic achievement gap between ethno-linguistic minority students and other students, as represented by test scores, dropout rates, and college admissions and completion rates, is the most persistent and pressing challenge facing public schools nationwide. The existing achievement gap indicates that many of our students are not receiving the…

  6. Comparison of base composition analysis and Sanger sequencing of mitochondrial DNA for four U.S. population groups.

    Science.gov (United States)

    Kiesler, Kevin M; Coble, Michael D; Hall, Thomas A; Vallone, Peter M

    2014-01-01

    A set of 711 samples from four U.S. population groups was analyzed using a novel mass spectrometry based method for mitochondrial DNA (mtDNA) base composition profiling. Comparison of the mass spectrometry results with Sanger sequencing derived data yielded a concordance rate of 99.97%. Length heteroplasmy was identified in 46% of samples and point heteroplasmy was observed in 6.6% of samples in the combined mass spectral and Sanger data set. Using discrimination capacity as a metric, Sanger sequencing of the full control region had the highest discriminatory power, followed by the mass spectrometry base composition method, which was more discriminating than Sanger sequencing of just the hypervariable regions. This trend is in agreement with the number of nucleotides covered by each of the three assays. Published by Elsevier Ireland Ltd.

  7. Screening PCR Versus Sanger Sequencing: Detection of CALR Mutations in Patients With Thrombocytosis.

    Science.gov (United States)

    Jeong, Ji Hun; Lee, Hwan Tae; Seo, Ja Young; Seo, Yiel Hea; Kim, Kyung Hee; Kim, Moon Jin; Lee, Jae Hoon; Park, Jinny; Hong, Jun Shik; Park, Pil Whan; Ahn, Jeong Yeal

    2016-07-01

    Mutations in calreticulin (CALR) have been reported to be key markers in the molecular diagnosis of myeloid proliferative neoplasms. In most previous reports, CALR mutations were analyzed by using Sanger sequencing. Here, we report a new, rapid, and convenient system for screening CALR mutations without sequencing. Eighty-three bone marrow samples were obtained from 81 patients with thrombocytosis. PCR primers were designed to detect wild-type CALR (product: 357 bp) and CALR with type 1 (product: 302 bp) and type 2 mutations (product: 272 bp) in one reaction. The results were confirmed by Sanger sequencing and compared with results from fragment analysis. The minimum detection limit of the screening PCR was 10 ng for type 1, 1 ng for type 2, and 0.1 ng for cases with both mutations. CALR type 1 and type 2 mutants were detected with screening PCR with a maximal analytical sensitivity of 3.2% and <0.8%, respectively. The screening PCR detected 94.1% (16/17) of mutation cases and showed concordant results with sequencing in the cases of type 1 and type 2 mutations. Sanger sequencing identified one novel mutation (c.1123_1132delinsTGC). Compared with sequencing, the screening PCR showed 94.1% sensitivity, 100.0% specificity, 100.0% positive predictive value, and 98.5% negative predictive value. Compared with fragment analysis, the screening PCR presented 88.9% sensitivity and 100.0% specificity. This screening PCR is a rapid, sensitive, and cost-effective method for the detection of major CALR mutations.

  8. Solar heating and hot water system installed at Southeast of Saline, Unified School District 306, Mentor, Kansas

    Science.gov (United States)

    1979-01-01

    The solar system, installed in a new building, was designed to provide 52 percent of the estimated annual space heating load and 84 percent of the estimated annual potable hot water requirement. The liquid flat plate collectors are ground-mounted and cover a total area of 5125 square feet. The system will provide supplemental heat for the school's closed-loop water-to-air heat pump system and domestic hot water. The storage medium is water inside steel tanks with a capacity of 11,828 gallons for space heating and 1,600 gallons for domestic hot water. The solar heating facility is described and drawings are presented of the completed system which was declared operational in September 1978, and has functioned successfully since.

  9. Hidden mutations in Cornelia de Lange syndrome limitations of sanger sequencing in molecular diagnostics.

    Science.gov (United States)

    Braunholz, Diana; Obieglo, Carolin; Parenti, Ilaria; Pozojevic, Jelena; Eckhold, Juliane; Reiz, Benedikt; Braenne, Ingrid; Wendt, Kerstin S; Watrin, Erwan; Vodopiutz, Julia; Rieder, Harald; Gillessen-Kaesbach, Gabriele; Kaiser, Frank J

    2015-01-01

    Cornelia de Lange syndrome (CdLS) is a well-characterized developmental disorder. The genetic cause of CdLS is a mutation in one of five associated genes (NIPBL, SMC1A, SMC3, RAD21, and HDAC8) accounting for about 70% of cases. To improve our current molecular diagnostic and to analyze some of CdLS candidate genes, we developed and established a gene panel approach. Because recent data indicate a high frequency of mosaic NIPBL mutations that were not detected by conventional sequencing approaches of blood DNA, we started to collect buccal mucosa (BM) samples of our patients that were negative for mutations in the known CdLS genes. Here, we report the identification of three mosaic NIPBL mutations by our high-coverage gene panel sequencing approach that were undetected by classical Sanger sequencing analysis of BM DNA. All mutations were confirmed by the use of highly sensitive SNaPshot fragment analysis using DNA from BM, urine, and fibroblast samples. In blood samples, we could not detect the respective mutation. Finally, in fibroblast samples from all three patients, Sanger sequencing could identify all the mutations. Thus, our study highlights the need for highly sensitive technologies in molecular diagnostic of CdLS to improve genetic diagnosis and counseling of patients and their families. © 2014 WILEY PERIODICALS, INC.

  10. iAssembler: a package for de novo assembly of Roche-454/Sanger transcriptome sequences

    Directory of Open Access Journals (Sweden)

    Zheng Yi

    2011-11-01

    Full Text Available Abstract Background Expressed Sequence Tags (ESTs have played significant roles in gene discovery and gene functional analysis, especially for non-model organisms. For organisms with no full genome sequences available, ESTs are normally assembled into longer consensus sequences for further downstream analysis. However current de novo EST assembly programs often generate large number of assembly errors that will negatively affect the downstream analysis. In order to generate more accurate consensus sequences from ESTs, tools are needed to reduce or eliminate errors from de novo assemblies. Results We present iAssembler, a pipeline that can assemble large-scale ESTs into consensus sequences with significantly higher accuracy than current existing assemblers. iAssembler employs MIRA and CAP3 assemblers to generate initial assemblies, followed by identifying and correcting two common types of transcriptome assembly errors: 1 ESTs from different transcripts (mainly alternatively spliced transcripts or paralogs are incorrectly assembled into same contigs; and 2 ESTs from same transcripts fail to be assembled together. iAssembler can be used to assemble ESTs generated using the traditional Sanger method and/or the Roche-454 massive parallel pyrosequencing technology. Conclusion We compared performances of iAssembler and several other de novo EST assembly programs using both Roche-454 and Sanger EST datasets. It demonstrated that iAssembler generated significantly more accurate consensus sequences than other assembly programs.

  11. Analysis of the Pythium ultimum transcriptome using Sanger and Pyrosequencing approaches

    Directory of Open Access Journals (Sweden)

    André Lévesque C

    2008-11-01

    Full Text Available Abstract Background Pythium species are an agriculturally important genus of plant pathogens, yet are not understood well at the molecular, genetic, or genomic level. They are closely related to other oomycete plant pathogens such as Phytophthora species and are ubiquitous in their geographic distribution and host rage. To gain a better understanding of its gene complement, we generated Expressed Sequence Tags (ESTs from the transcriptome of Pythium ultimum DAOM BR144 (= ATCC 200006 = CBS 805.95 using two high throughput sequencing methods, Sanger-based chain termination sequencing and pyrosequencing-based sequencing-by-synthesis. Results A single half-plate pyrosequencing (454 FLX run on adapter-ligated cDNA from a normalized cDNA population generated 90,664 reads with an average read length of 190 nucleotides following cleaning and removal of sequences shorter than 100 base pairs. After clustering and assembly, a total of 35,507 unique sequences were generated. In parallel, 9,578 reads were generated from a library constructed from the same normalized cDNA population using dideoxy chain termination Sanger sequencing, which upon clustering and assembly generated 4,689 unique sequences. A hybrid assembly of both Sanger- and pyrosequencing-derived ESTs resulted in 34,495 unique sequences with 1,110 sequences (3.2% that were solely derived from Sanger sequencing alone. A high degree of similarity was seen between P. ultimum sequences and other sequenced plant pathogenic oomycetes with 91% of the hybrid assembly derived sequences > 500 bp having similarity to sequences from plant pathogenic Phytophthora species. An analysis of Gene Ontology assignments revealed a similar representation of molecular function ontologies in the hybrid assembly in comparison to the predicted proteomes of three Phytophthora species, suggesting a broad representation of the P. ultimum transcriptome was present in the normalized cDNA population. P. ultimum sequences with

  12. MutAid: Sanger and NGS Based Integrated Pipeline for Mutation Identification, Validation and Annotation in Human Molecular Genetics.

    Science.gov (United States)

    Pandey, Ram Vinay; Pabinger, Stephan; Kriegner, Albert; Weinhäusel, Andreas

    2016-01-01

    Traditional Sanger sequencing as well as Next-Generation Sequencing have been used for the identification of disease causing mutations in human molecular research. The majority of currently available tools are developed for research and explorative purposes and often do not provide a complete, efficient, one-stop solution. As the focus of currently developed tools is mainly on NGS data analysis, no integrative solution for the analysis of Sanger data is provided and consequently a one-stop solution to analyze reads from both sequencing platforms is not available. We have therefore developed a new pipeline called MutAid to analyze and interpret raw sequencing data produced by Sanger or several NGS sequencing platforms. It performs format conversion, base calling, quality trimming, filtering, read mapping, variant calling, variant annotation and analysis of Sanger and NGS data under a single platform. It is capable of analyzing reads from multiple patients in a single run to create a list of potential disease causing base substitutions as well as insertions and deletions. MutAid has been developed for expert and non-expert users and supports four sequencing platforms including Sanger, Illumina, 454 and Ion Torrent. Furthermore, for NGS data analysis, five read mappers including BWA, TMAP, Bowtie, Bowtie2 and GSNAP and four variant callers including GATK-HaplotypeCaller, SAMTOOLS, Freebayes and VarScan2 pipelines are supported. MutAid is freely available at https://sourceforge.net/projects/mutaid.

  13. Assessing the Distribution of Fiscal and Personnel Resources across Schools. A Report Prepared for Twin Rivers Unified School District. SSFR Research Report #01 (TRUSD)

    Science.gov (United States)

    Chambers, Jay G.; Levin, Jesse; Brodziak, Iliana; Chan, Derek

    2010-01-01

    Using fiscal data provided by the finance office of the school district, and personnel data obtained from the California Basic Education Data System (maintained by the California Department of Education, or CDE), the authors present analyses to provide a foundation for local policymakers that may be used to assess whether there are inequities in…

  14. Reanalyze unassigned reads in Sanger based metagenomic data using conserved gene adjacency

    Directory of Open Access Journals (Sweden)

    Hsu Ming-Tsung

    2010-11-01

    Full Text Available Abstract Background Investigation of metagenomes provides greater insight into uncultured microbial communities. The improvement in sequencing technology, which yields a large amount of sequence data, has led to major breakthroughs in the field. However, at present, taxonomic binning tools for metagenomes discard 30-40% of Sanger sequencing data due to the stringency of BLAST cut-offs. In an attempt to provide a comprehensive overview of metagenomic data, we re-analyzed the discarded metagenomes by using less stringent cut-offs. Additionally, we introduced a new criterion, namely, the evolutionary conservation of adjacency between neighboring genes. To evaluate the feasibility of our approach, we re-analyzed discarded contigs and singletons from several environments with different levels of complexity. We also compared the consistency between our taxonomic binning and those reported in the original studies. Results Among the discarded data, we found that 23.7 ± 3.9% of singletons and 14.1 ± 1.0% of contigs were assigned to taxa. The recovery rates for singletons were higher than those for contigs. The Pearson correlation coefficient revealed a high degree of similarity (0.94 ± 0.03 at the phylum rank and 0.80 ± 0.11 at the family rank between the proposed taxonomic binning approach and those reported in original studies. In addition, an evaluation using simulated data demonstrated the reliability of the proposed approach. Conclusions Our findings suggest that taking account of conserved neighboring gene adjacency improves taxonomic assignment when analyzing metagenomes using Sanger sequencing. In other words, utilizing the conserved gene order as a criterion will reduce the amount of data discarded when analyzing metagenomes.

  15. 77 FR 43350 - Draft Environmental Assessment and Proposed Habitat Conservation Plan for the San Diego Unified...

    Science.gov (United States)

    2012-07-24

    ... San Diego Unified School District's Jonas Salk Elementary School Project in the City of San Diego, San Diego County, CA AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of availability: request... Elementary School Project in response to an application from the San Diego Unified School District (District...

  16. Simplified large-scale Sanger genome sequencing for influenza A/H3N2 virus.

    Directory of Open Access Journals (Sweden)

    Hong Kai Lee

    Full Text Available BACKGROUND: The advent of next-generation sequencing technologies and the resultant lower costs of sequencing have enabled production of massive amounts of data, including the generation of full genome sequences of pathogens. However, the small genome size of the influenza virus arguably justifies the use of the more conventional Sanger sequencing technology which is still currently more readily available in most diagnostic laboratories. RESULTS: We present a simplified Sanger-based genome sequencing method for sequencing the influenza A/H3N2 virus in a large-scale format. The entire genome sequencing was completed with 19 reverse transcription-polymerase chain reactions (RT-PCRs and 39 sequencing reactions. This method was tested on 15 native clinical samples and 15 culture isolates, respectively, collected between 2009 and 2011. The 15 native clinical samples registered quantification cycle values ranging from 21.0 to 30.56, which were equivalent to 2.4×10(3-1.4×10(6 viral copies/µL of RNA extract. All the PCR-amplified products were sequenced directly without PCR product purification. Notably, high quality sequencing data up to 700 bp were generated for all the samples tested. The completed sequence covered 408,810 nucleotides in total, with 13,627 nucleotides per genome, attaining 100% coding completeness. Of all the bases produced, an average of 89.49% were Phred quality value 40 (QV40 bases (representing an accuracy of circa one miscall for every 10,000 bases or higher, and an average of 93.46% were QV30 bases (one miscall every 1000 bases or higher. CONCLUSIONS: This sequencing protocol has been shown to be cost-effective and less labor-intensive in obtaining full influenza genomes. The constant high quality of sequences generated imparts confidence in extending the application of this non-purified amplicon sequencing approach to other gene sequencing assays, with appropriate use of suitably designed primers.

  17. Noncontinuously binding loop-out primers for avoiding problematic DNA sequences in PCR and sanger sequencing.

    Science.gov (United States)

    Sumner, Kelli; Swensen, Jeffrey J; Procter, Melinda; Jama, Mohamed; Wooderchak-Donahue, Whitney; Lewis, Tracey; Fong, Michael; Hubley, Lindsey; Schwarz, Monica; Ha, Youna; Paul, Eleri; Brulotte, Benjamin; Lyon, Elaine; Bayrak-Toydemir, Pinar; Mao, Rong; Pont-Kingdon, Genevieve; Best, D Hunter

    2014-09-01

    We present a method in which noncontinuously binding (loop-out) primers are used to exclude regions of DNA that typically interfere with PCR amplification and/or analysis by Sanger sequencing. Several scenarios were tested using this design principle, including M13-tagged PCR primers, non-M13-tagged PCR primers, and sequencing primers. With this technique, a single oligonucleotide is designed in two segments that flank, but do not include, a short region of problematic DNA sequence. During PCR amplification or sequencing, the problematic region is looped-out from the primer binding site, where it does not interfere with the reaction. Using this method, we successfully excluded regions of up to 46 nucleotides. Loop-out primers were longer than traditional primers (27 to 40 nucleotides) and had higher melting temperatures. This method allows the use of a standardized PCR protocol throughout an assay, keeps the number of PCRs to a minimum, reduces the chance for laboratory error, and, above all, does not interrupt the clinical laboratory workflow.

  18. On Performance Analysis, Evaluation, and Enhancement of Reading Brain Function Using Sanger's Rule

    Directory of Open Access Journals (Sweden)

    Hassan M. H. Mustafa

    2016-08-01

    Full Text Available This piece of research adopts an interdisciplinary conceptual approach that incorporates Artificial Neural Networks (ANN with learning and cognitive sciences. Specifically, it considers modeling of associative memorization to introduce optimal analysis for development of reading brain performance. Herein, this brain performance simulated realistically using ANNs self-organized modeling paradigm. That namely: the Generalized Hebbian Algorithm (GHA, also known in the literature as Sanger's rule, is a linear feed forward neural network model for unsupervised learning with applications primarily in principal components analysis. Furthermore, it inspired by functioning of highly specialized biological neurons in reading brain based on the organization the brain's structures/substructures. In accordance with the prevailing concept of individual intrinsic characterized properties of highly specialized neurons. Presented models have been in close correspondence with set of neurons’ performance for developing reading brain in a significant way. More specifically, herein, introduced model concerned with their important role played in carrying out cognitive reading brain function's outcomes. Accordingly, the cognitive goal for reading brain is to translate that seen word (orthographic word-from into a spoken word (phonological word-form. In this context herein, the presented work illustrates via ANN simulation results: How ensembles of highly specialized neurons could be dynamically involved in performing associative memorization cognitive function for developing reading brain.

  19. Implementing a genomic data management system using iRODS in the Wellcome Trust Sanger Institute

    Directory of Open Access Journals (Sweden)

    Sale Kevin

    2011-09-01

    Full Text Available Abstract Background Increasingly large amounts of DNA sequencing data are being generated within the Wellcome Trust Sanger Institute (WTSI. The traditional file system struggles to handle these increasing amounts of sequence data. A good data management system therefore needs to be implemented and integrated into the current WTSI infrastructure. Such a system enables good management of the IT infrastructure of the sequencing pipeline and allows biologists to track their data. Results We have chosen a data grid system, iRODS (Rule-Oriented Data management systems, to act as the data management system for the WTSI. iRODS provides a rule-based system management approach which makes data replication much easier and provides extra data protection. Unlike the metadata provided by traditional file systems, the metadata system of iRODS is comprehensive and allows users to customize their own application level metadata. Users and IT experts in the WTSI can then query the metadata to find and track data. The aim of this paper is to describe how we designed and used (from both system and user viewpoints iRODS as a data management system. Details are given about the problems faced and the solutions found when iRODS was implemented. A simple use case describing how users within the WTSI use iRODS is also introduced. Conclusions iRODS has been implemented and works as the production system for the sequencing pipeline of the WTSI. Both biologists and IT experts can now track and manage data, which could not previously be achieved. This novel approach allows biologists to define their own metadata and query the genomic data using those metadata.

  20. Comparing Whole-Genome Sequencing with Sanger Sequencing for spa Typing of Methicillin-Resistant Staphylococcus aureus

    DEFF Research Database (Denmark)

    Bartels, Mette Damkjaer; Petersen, Andreas; Worning, Peder

    2014-01-01

    spa typing of methicillin-resistant Staphylococcus aureus (MRSA) has traditionally been done by PCR amplification and Sanger sequencing of the spa repeat region. At Hvidovre Hospital, Denmark, whole-genome sequencing (WGS) of all MRSA isolates has been performed routinely since January 2013......, and an in-house analysis pipeline determines the spa types. Due to national surveillance, all MRSA isolates are sent to Statens Serum Institut, where the spa type is determined by PCR and Sanger sequencing. The purpose of this study was to evaluate the reliability of the spa types obtained by 150-bp paired......-end Illumina WGS. MRSA isolates from new MRSA patients in 2013 (n = 699) in the capital region of Denmark were included. We found a 97% agreement between spa types obtained by the two methods. All isolates achieved a spa type by both methods. Nineteen isolates differed in spa types by the two methods, in most...

  1. Homozygosity mapping and targeted sanger sequencing reveal genetic defects underlying inherited retinal disease in families from pakistan.

    Directory of Open Access Journals (Sweden)

    Maleeha Maria

    Full Text Available Homozygosity mapping has facilitated the identification of the genetic causes underlying inherited diseases, particularly in consanguineous families with multiple affected individuals. This knowledge has also resulted in a mutation dataset that can be used in a cost and time effective manner to screen frequent population-specific genetic variations associated with diseases such as inherited retinal disease (IRD.We genetically screened 13 families from a cohort of 81 Pakistani IRD families diagnosed with Leber congenital amaurosis (LCA, retinitis pigmentosa (RP, congenital stationary night blindness (CSNB, or cone dystrophy (CD. We employed genome-wide single nucleotide polymorphism (SNP array analysis to identify homozygous regions shared by affected individuals and performed Sanger sequencing of IRD-associated genes located in the sizeable homozygous regions. In addition, based on population specific mutation data we performed targeted Sanger sequencing (TSS of frequent variants in AIPL1, CEP290, CRB1, GUCY2D, LCA5, RPGRIP1 and TULP1, in probands from 28 LCA families.Homozygosity mapping and Sanger sequencing of IRD-associated genes revealed the underlying mutations in 10 families. TSS revealed causative variants in three families. In these 13 families four novel mutations were identified in CNGA1, CNGB1, GUCY2D, and RPGRIP1.Homozygosity mapping and TSS revealed the underlying genetic cause in 13 IRD families, which is useful for genetic counseling as well as therapeutic interventions that are likely to become available in the near future.

  2. Carnap on unified science.

    Science.gov (United States)

    Klev, Ansten

    2016-10-01

    Unified science is a recurring theme in Carnap's work from the time of the Aufbau until the end of the 1930's. The theme is not constant, but knows several variations. I shall extract three quite precise formulations of the thesis of unified science from Carnap's work during this period: from the Aufbau, from Carnap's so-called syntactic period, and from Testability and Meaning and related papers. My main objective is to explain these formulations and to discuss their relation, both to each other and to other aspects of Carnap's work. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. THE EDUCATIONAL PARK, THE MIDDLE SCHOOL--A REPORT ON MATERIAL ON FILE IN THE BERKELEY UNIFIED SCHOOL DISTRICT RESEARCH OFFICE AND SOME ADDITIONAL SOURCES FROM THE BERKELEY SCHOOLS' PROFESSIONAL LIBRARY. (TITLE SUPPLIED)

    Science.gov (United States)

    DUNN, SUSAN V.

    A REVIEW OF LITERATURE OUTLINING THE MAIN ADVANTAGES AND DISADVANTAGES OF EDUCATIONAL PARKS AND MIDDLE SCHOOLS IS PRESENTED. EDUCATIONAL PARKS ARE DISTINGUISHED BY THEIR LARGE SIZE (FROM 10,000 TO 25,000 STUDENTS), CENTRAL LOCATION, ADMINISTRATIVE CENTRALIZATION, AND DECENTRALIZED SCHOOL DESIGN. THE ADVANTAGES OF EDUCATIONAL PARKS INCLUDE (1) A…

  4. Finite unified models

    Energy Technology Data Exchange (ETDEWEB)

    Kapetanakis, D. (Technische Univ. Muenchen, Garching (Germany). Physik Dept.); Mondragon, M. (Technische Univ. Muenchen, Garching (Germany). Physik Dept.); Zoupanos, G. (National Technical Univ., Athens (Greece). Physics Dept.)

    1993-09-01

    We present phenomenologically viable SU(5) unified models which are finite to all orders before the spontaneous symmetry breaking. In the case of two models with three families the top quark mass is predicted to be 178.8 GeV. (orig.)

  5. Hybrid Unifying Variable Supernetwork Model

    Institute of Scientific and Technical Information of China (English)

    LIU; Qiang; FANG; Jin-qing; LI; Yong

    2015-01-01

    In order to compare new phenomenon of topology change,evolution,hybrid ratio and network characteristics of unified hybrid network theoretical model with unified hybrid supernetwork model,this paper constructed unified hybrid variable supernetwork model(HUVSM).The first layer introduces a hybrid ratio dr,the

  6. Unified Index Unveiled

    Institute of Scientific and Technical Information of China (English)

    RENWEI

    2005-01-01

    China unveiled a unified stock index to track both markets in Shanghai and Shenzhen in April, a move likely to open a floodgate for more trading derivatives such as index futures. The new index, with 300 component companies traded on Shanghai and Shenzhen stock exchanges, will be the first of its kind on the mainland. The index members will be the largest 300 stocks - 180 from Shanghai and 120 from Shenzhen - in terms of market capitalization,

  7. Unified Engineering Software System

    Science.gov (United States)

    Purves, L. R.; Gordon, S.; Peltzman, A.; Dube, M.

    1989-01-01

    Collection of computer programs performs diverse functions in prototype engineering. NEXUS, NASA Engineering Extendible Unified Software system, is research set of computer programs designed to support full sequence of activities encountered in NASA engineering projects. Sequence spans preliminary design, design analysis, detailed design, manufacturing, assembly, and testing. Primarily addresses process of prototype engineering, task of getting single or small number of copies of product to work. Written in FORTRAN 77 and PROLOG.

  8. Operation Unified Protector

    DEFF Research Database (Denmark)

    Buhl, Kenneth Øhlenschlæger

    2012-01-01

    Formålet med denne artikel er at se nærmere på erfaringerne fra den maritime kampagne under den militære indsats i konflikten i Libyen i 2011, som i NATO regi blev kendt som Operation Unified Protector (OUP). Dækningen i de danske medier fokuserede primært på luftkampagnen, hvilket må tilskrives,...

  9. Unifying Perceptual Learning

    Directory of Open Access Journals (Sweden)

    Philip J. Kellman

    2011-05-01

    Full Text Available What is the relation between perceptual learning (PL in basic sensory discriminations and in more complex tasks, including real-world learning tasks? Most recent PL work focuses on the former, using simple sensory dimensions and a few specific stimulus values. In contrast, other PL research and virtually all real-world tasks involve discovery of invariance amidst variation, and may also involve PL working synergistically with other cognitive abilities. In this talk I will suggest that, despite superficial differences, low- and high-level PL tasks draw upon—and reveal—a unified type of learning. I will consider several arguments that have been advanced in favor of confining perceptual learning to plasticity at the earliest cortical levels along with models of PL based on receptive field change vs. selection. These analyses do not support the idea of a separate low-level process but do support both the abstract character of PL and its dependence on unifying notions of discovery and selection. In the final part of the talk, I will relate this unified view of PL to direct practical applications. Learning technology based on PL modules (PLMs can address elusive aspects of learning, including pattern recognition, transfer, and fluency, even in high-level, symbolic domains, such as mathematics learning.

  10. Assessing the Distribution of Fiscal and Personnel Resources across Schools. A Report Prepared for Los Angeles Unified School District. SSFR Research Report #01 (LAUSD). Strategic School Funding for Results (SSFR)

    Science.gov (United States)

    Chambers, Jay G.; Levin, Jesse; Brodziak, Iliana; Chan, Derek

    2010-01-01

    Using fiscal data provided by the finance office of the school district, and personnel data obtained from the California Basic Education Data System maintained by the California Department of Education (CDE), the authors present analyses to provide a foundation for local policymakers that may be used to assess whether there are inequities in the…

  11. Application of the Unified Theory of Acceptance and Use of Technology to the Use of ICT by Undergraduates in the School of Education, Makerere University

    Science.gov (United States)

    Bakkabulindi, F. E. K.; Mugagga, A. M.; Shopi, J. M.; Kabasiita, J.

    2015-01-01

    This survey sought to establish how performance expectancy (PE), effort expectancy (EE), social influence (SI) and facilitating conditions (FC) related to the use of ICT by undergraduate students in the School of Education at Makerere University. Descriptive analysis was done using percentages and means, while hypotheses were tested using Multiple…

  12. Unified field theories

    CERN Document Server

    Vizgin, Vladimir P

    2011-01-01

    Despite the rapidly expanding ambit of physical research and the continual appearance of new branches of physics, the main thrust in its development has been the attempt at a theoretical synthesis of the entire body of physical knowledge. Vladimir Vizgin's work presents perhaps the first systematic historico-scientific study of the formation and development of the unified field theories in the general context of 20th century physics. Concentrating on the first three decades of the century and drawing extensively on Russian sources, the author analyses the first successes, failures and paths of

  13. IROme, a new high-throughput molecular tool for the diagnosis of inherited retinal dystrophies-a price comparison with Sanger sequencing.

    Science.gov (United States)

    Schorderet, Daniel F; Bernasconi, Maude; Tiab, Leila; Favez, Tatiana; Escher, Pascal

    2014-01-01

    The molecular diagnosis of retinal dystrophies (RD) is difficult because of genetic and clinical heterogeneity. Previously, the molecular screening of genes was done one by one, sometimes in a scheme based on the frequency of sequence variants and the number of exons/length of the candidate genes. Payment for these procedures was complicated and the sequential billing of several genes created endless paperwork. We therefore evaluated the costs of generating and sequencing a hybridization-based DNA library enriched for the 64 most frequently mutated genes in RD, called IROme, and compared them to the costs of amplifying and sequencing these genes by the Sanger method. The production cost generated by the high-throughput (HT) sequencing of IROme was established at CHF 2,875.75 per case. Sanger sequencing of the same exons cost CHF 69,399.02. Turnaround time of the analysis was 3 days for IROme. For Sanger sequencing, it could only be estimated, as we never sequenced all 64 genes in one single patient. Sale cost for IROme calculated on the basis of the sale cost of one exon by Sanger sequencing is CHF 8,445.88, which corresponds to the sale price of 40 exons. In conclusion, IROme is cheaper and faster than Sanger sequencing and therefore represents a sound approach for the diagnosis of RD, both scientifically and economically. As a drop in the costs of HT sequencing is anticipated, target resequencing might become the new gold standard in the molecular diagnosis of RD.

  14. Comparison of pyrosequencing, Sanger sequencing, and melting curve analysis for detection of low-frequency macrolide-resistant mycoplasma pneumoniae quasispecies in respiratory specimens.

    Science.gov (United States)

    Chan, Kwok-Hung; To, Kelvin K W; Chan, Betsy W K; Li, Clara P Y; Chiu, Susan S; Yuen, Kwok-Yung; Ho, Pak-Leung

    2013-08-01

    Macrolide-resistant Mycoplasma pneumoniae (MRMP) is emerging worldwide and has been associated with treatment failure. In this study, we used pyrosequencing to detect low-frequency MRMP quasispecies in respiratory specimens, and we compared the findings with those obtained by Sanger sequencing and SimpleProbe PCR coupled with a melting curve analysis (SimpleProbe PCR). Sanger sequencing, SimpleProbe PCR, and pyrosequencing were successfully performed for 96.7% (88/91), 96.7% (88/91), and 93.4% (85/91) of the M. pneumoniae-positive specimens, respectively. The A-to-G transition at position 2063 was the only mutation identified. Pyrosequencing identified A2063G MRMP quasispecies populations in 78.8% (67/88) of the specimens. Only 38.8% (26/67) of these specimens with the A2063G quasispecies detected by pyrosequencing were found to be A2063G quasispecies by Sanger sequencing or SimpleProbe PCR. The specimens that could be detected by SimpleProbe PCR and Sanger sequencing had higher frequencies of MRMP quasispecies (51% to 100%) than those that could not be detected by those two methods (1% to 44%). SimpleProbe PCR correctly categorized all specimens that were identified as wild type or mutant by Sanger sequencing. The clinical characteristics of the patients were not significantly different when they were grouped by the presence or absence of MRMP quasispecies, while patients with MRMP identified by Sanger sequencing more often required a switch from macrolides to an alternative M. pneumoniae-targeted therapy. The clinical significance of mutant quasispecies should be investigated further with larger patient populations and with specimens obtained before and after macrolide therapy.

  15. Finite unified theories

    Energy Technology Data Exchange (ETDEWEB)

    Mondragon, M [Inst. de Fisica, Universidad Nacional Autonoma de Mexico, Apdo. Postal 20-364, Mexico 01000 D.F. (Mexico); Zoupanos, G, E-mail: myriam@fisica.unam.m, E-mail: zoupanos@mail.cern.c [Physics Department, National Technical University of Athens, Zografou Campus: Heroon Polytechniou 9, 15780 Zografou, Athens (Greece)

    2009-06-01

    All-loop Finite Unified Theories (FUTs) are very interesting N=1 GUTs in which a complete reduction of couplings has been achieved. FUTs realize an old field theoretical dream and have remarkable predictive power. Reduction of dimensionless couplings in N=1 GUTs is achieved by searching for renormalization group invariant (RGI) relations among them holding beyond the unification scale. Finiteness results from the fact that there exists RGI relations among dimensionless couplings that guarantee the vanishing of the beta-functions in certain N=1 supersymmetric GUTS even to all orders. Furthermore, developments in the soft supersymmetry breaking sector of N=1 GUTs and FUTs lead to exact RGI relations also in this dimensionful sector of the theories. Of particular interest for the construction of realistic theories is a RGI sum rule for the soft scalar masses holding to all orders.

  16. Effects of Positive Unified Behavior Support on Instruction

    Science.gov (United States)

    Scott, John S.; White, Richard; Algozzine, Bob; Algozzine, Kate

    2009-01-01

    "Positive Unified Behavior Support" (PUBS) is a school-wide intervention designed to establish uniform attitudes, expectations, correction procedures, and roles among faculty, staff, and administration. PUBS is grounded in the general principles of positive behavior support and represents a straightforward, practical implementation model. When…

  17. A Unifying Modularity in Networks

    Institute of Scientific and Technical Information of China (English)

    HAO Jun-Jun; CAI Shui-Ming; HE Qin-Bin; LIU Zeng-Rong

    2010-01-01

    @@ We propose a new modularity criterion in complex networks,called the unifying modularity q which is independent of the number of partitions.It is shown that,for a given network,the relationship between the upper limit of Q and the number of the partitions,k,is sup(Qk)=(k-1)/k.Since the range of Q for each partition number is inconsistent,we try to extend the concept Q to unifying modularity q,which is independent of the number of partitions.Subsequently,we indicate that it is more accurately to determine the number of partitions by using unifying modularity q than Q.

  18. Seven Deadliest Unified Communications Attacks

    CERN Document Server

    York, Dan

    2010-01-01

    Do you need to keep up with the latest hacks, attacks, and exploits effecting Unified Communications technology? Then you need Seven Deadliest Unified Communication Attacks. This book pinpoints the most dangerous hacks and exploits specific to Unified Communications, laying out the anatomy of these attacks including how to make your system more secure. You will discover the best ways to defend against these vicious hacks with step-by-step instruction and learn techniques to make your computer and network impenetrable. Attacks featured in this book include: UC Ecosystem Attacks Insecure Endpo

  19. Unified Maximally Natural Supersymmetry

    CERN Document Server

    Huang, Junwu

    2016-01-01

    Maximally Natural Supersymmetry, an unusual weak-scale supersymmetric extension of the Standard Model based upon the inherently higher-dimensional mechanism of Scherk-Schwarz supersymmetry breaking (SSSB), possesses remarkably good fine tuning given present LHC limits. Here we construct a version with precision $SU(2)_{\\rm L} \\times U(1)_{\\rm Y} $ unification: $\\sin^2 \\theta_W(M_Z) \\simeq 0.231$ is predicted to $\\pm 2\\%$ by unifying $SU(2)_{\\rm L} \\times U(1)_{\\rm Y} $ into a 5D $SU(3)_{\\rm EW}$ theory at a Kaluza-Klein scale of $1/R_5 \\sim 4.4\\,{\\rm TeV}$, where SSSB is simultaneously realised. Full unification with $SU(3)_{\\rm C}$ is accommodated by extending the 5D theory to a $N=4$ supersymmetric $SU(6)$ gauge theory on a 6D rectangular orbifold at $1/R_6 \\sim 40 \\,{\\rm TeV}$. TeV-scale states beyond the SM include exotic charged fermions implied by $SU(3)_{\\rm EW}$ with masses lighter than $\\sim 1.2\\,{\\rm TeV}$, and squarks in the mass range $1.4\\,{\\rm TeV} - 2.3\\,{\\rm TeV}$, providing distinct signature...

  20. 454 next generation-sequencing outperforms allele-specific PCR, Sanger sequencing, and pyrosequencing for routine KRAS mutation analysis of formalin-fixed, paraffin-embedded samples.

    Science.gov (United States)

    Altimari, Annalisa; de Biase, Dario; De Maglio, Giovanna; Gruppioni, Elisa; Capizzi, Elisa; Degiovanni, Alessio; D'Errico, Antonia; Pession, Annalisa; Pizzolitto, Stefano; Fiorentino, Michelangelo; Tallini, Giovanni

    2013-01-01

    Detection of KRAS mutations in archival pathology samples is critical for therapeutic appropriateness of anti-EGFR monoclonal antibodies in colorectal cancer. We compared the sensitivity, specificity, and accuracy of Sanger sequencing, ARMS-Scorpion (TheraScreen®) real-time polymerase chain reaction (PCR), pyrosequencing, chip array hybridization, and 454 next-generation sequencing to assess KRAS codon 12 and 13 mutations in 60 nonconsecutive selected cases of colorectal cancer. Twenty of the 60 cases were detected as wild-type KRAS by all methods with 100% specificity. Among the 40 mutated cases, 13 were discrepant with at least one method. The sensitivity was 85%, 90%, 93%, and 92%, and the accuracy was 90%, 93%, 95%, and 95% for Sanger sequencing, TheraScreen real-time PCR, pyrosequencing, and chip array hybridization, respectively. The main limitation of Sanger sequencing was its low analytical sensitivity, whereas TheraScreen real-time PCR, pyrosequencing, and chip array hybridization showed higher sensitivity but suffered from the limitations of predesigned assays. Concordance between the methods was k = 0.79 for Sanger sequencing and k > 0.85 for the other techniques. Tumor cell enrichment correlated significantly with the abundance of KRAS-mutated deoxyribonucleic acid (DNA), evaluated as ΔCt for TheraScreen real-time PCR (P = 0.03), percentage of mutation for pyrosequencing (P = 0.001), ratio for chip array hybridization (P = 0.003), and percentage of mutation for 454 next-generation sequencing (P = 0.004). Also, 454 next-generation sequencing showed the best cross correlation for quantification of mutation abundance compared with all the other methods (P < 0.001). Our comparison showed the superiority of next-generation sequencing over the other techniques in terms of sensitivity and specificity. Next-generation sequencing will replace Sanger sequencing as the reference technique for diagnostic detection of KRAS mutation in archival tumor tissues.

  1. A Comprehensive Transcriptome Assembly of Pigeonpea (Cajanus cajan L.) using Sanger and Second-Generation Sequencing Platforms

    Science.gov (United States)

    Kudapa, Himabindu; Bharti, Arvind K.; Cannon, Steven B.; Farmer, Andrew D.; Mulaosmanovic, Benjamin; Kramer, Robin; Bohra, Abhishek; Weeks, Nathan T.; Crow, John A.; Tuteja, Reetu; Shah, Trushar; Dutta, Sutapa; Gupta, Deepak K.; Singh, Archana; Gaikwad, Kishor; Sharma, Tilak R.; May, Gregory D.; Singh, Nagendra K.; Varshney, Rajeev K.

    2012-01-01

    A comprehensive transcriptome assembly for pigeonpea has been developed by analyzing 128.9 million short Illumina GA IIx single end reads, 2.19 million single end FLX/454 reads, and 18 353 Sanger expressed sequenced tags from more than 16 genotypes. The resultant transcriptome assembly, referred to as CcTA v2, comprised 21 434 transcript assembly contigs (TACs) with an N50 of 1510 bp, the largest one being ∼8 kb. Of the 21 434 TACs, 16 622 (77.5%) could be mapped on to the soybean genome build 1.0.9 under fairly stringent alignment parameters. Based on knowledge of intron junctions, 10 009 primer pairs were designed from 5033 TACs for amplifying intron spanning regions (ISRs). By using in silico mapping of BAC-end-derived SSR loci of pigeonpea on the soybean genome as a reference, putative mapping positions at the chromosome level were predicted for 6284 ISR markers, covering all 11 pigeonpea chromosomes. A subset of 128 ISR markers were analyzed on a set of eight genotypes. While 116 markers were validated, 70 markers showed one to three alleles, with an average of 0.16 polymorphism information content (PIC) value. In summary, the CcTA v2 transcript assembly and ISR markers will serve as a useful resource to accelerate genetic research and breeding applications in pigeonpea. PMID:22241453

  2. 454 Pyrosequencing and Sanger sequencing of tropical mycorrhizal fungi provide similar results but reveal substantial methodological biases.

    Science.gov (United States)

    Tedersoo, Leho; Nilsson, R Henrik; Abarenkov, Kessy; Jairus, Teele; Sadam, Ave; Saar, Irja; Bahram, Mohammad; Bechem, Eneke; Chuyong, George; Kõljalg, Urmas

    2010-10-01

    • Compared with Sanger sequencing-based methods, pyrosequencing provides orders of magnitude more data on the diversity of organisms in their natural habitat, but its technological biases and relative accuracy remain poorly understood. • This study compares the performance of pyrosequencing and traditional sequencing for species' recovery of ectomycorrhizal fungi on root tips in a Cameroonian rain forest and addresses biases related to multi-template PCR and pyrosequencing analyses. • Pyrosequencing and the traditional method yielded qualitatively similar results, but there were slight, but significant, differences that affected the taxonomic view of the fungal community. We found that most pyrosequencing singletons were artifactual and contained a strongly elevated proportion of insertions compared with natural intra- and interspecific variation. The alternative primers, DNA extraction methods and PCR replicates strongly influenced the richness and community composition as recovered by pyrosequencing. • Pyrosequencing offers a powerful alternative for the identification of ectomycorrhizal fungi in pooled root samples, but requires careful selection of molecular tools. A well-populated backbone database facilitates the detection of biological and technical artifacts. The pyrosequencing pipeline is available at http://unite.ut.ee/454pipeline.tgz.

  3. A Comprehensive Transcriptome Assembly of Pigeonpea (Cajanus cajan L.) using Sanger and Second-Generation Sequencing Platforms

    Institute of Scientific and Technical Information of China (English)

    Himabindu Kudapa; Reetu Tuteja; Trushar Shah; Sutapa Dutta; Deepak K.Gupta; Archana Singh; Kishor Gaikwad; Tilak R.Sharma; Gregory D.May; Nagendra K.Singh; Rajeev K.Varshney; Arvind K.Bharti; Steven B.Cannon; Andrew D.Farmer; Benjamin Mulaosmanovic; Robin Kramer; Abhishek Bohra; Nathan T.Weeks; John A.Crow

    2012-01-01

    A comprehensive transcriptome assembly for pigeonpea has been developed by analyzing 128.9 million short Illumina GA Ⅱx single end reads,2.19 million single end FLX/454 reads,and 18353 Sanger expressed sequenced tags from more than 16 genotypes.The resultant transcriptome assembly,referred to as CcTA v2,comprised 21434 transcript assembly contigs (TACs) with an N50 of 1510 bp,the largest one being ~8 kb.Of the 21434 TACs,16622 (77.5%) could be mapped on to the soybean genome build 1.0.9 under fairly stringent alignment parameters.Based on knowledge of intron junctions,10009 primer pairs were designed from 5033 TACs for amplifying intron spanning regions (ISRs).By using in silico mapping of BAC-end-derived SSR loci of pigeonpea on the soybean genome as a reference,putative mapping positions at the chromosome level were predicted for 6284 ISR markers,covering all 11 pigeonpea chromosomes.A subset of 128 ISR markers were analyzed on a set of eight genotypes.While 116 markers were validated,70 markers showed one to three alleles,with an average of 0.16 polymorphism information content (PIC) value.In summary,the CcTA v2 transcript assembly and ISR markers will serve as a useful resource to accelerate genetic research and breeding applications in pigeonpea.

  4. Identification of novel BRCA founder mutations in Middle Eastern breast cancer patients using capture and Sanger sequencing analysis.

    Science.gov (United States)

    Bu, Rong; Siraj, Abdul K; Al-Obaisi, Khadija A S; Beg, Shaham; Al Hazmi, Mohsen; Ajarim, Dahish; Tulbah, Asma; Al-Dayel, Fouad; Al-Kuraya, Khawla S

    2016-09-01

    Ethnic differences of breast cancer genomics have prompted us to investigate the spectra of BRCA1 and BRCA2 mutations in different populations. The prevalence and effect of BRCA 1 and BRCA 2 mutations in Middle Eastern population is not fully explored. To characterize the prevalence of BRCA mutations in Middle Eastern breast cancer patients, BRCA mutation screening was performed in 818 unselected breast cancer patients using Capture and/or Sanger sequencing. 19 short tandem repeat (STR) markers were used for founder mutation analysis. In our study, nine different types of deleterious mutation were identified in 28 (3.4%) cases, 25 (89.3%) cases in BRCA 1 and 3 (10.7%) cases in BRCA 2. Seven recurrent mutations identified accounted for 92.9% (26/28) of all the mutant cases. Haplotype analysis was performed to confirm c.1140 dupG and c.4136_4137delCT mutations as novel putative founder mutation, accounting for 46.4% (13/28) of all BRCA mutant cases and 1.6% (13/818) of all the breast cancer cases, respectively. Moreover, BRCA 1 mutation was significantly associated with BRCA 1 protein expression loss (p = 0.0005). Our finding revealed that a substantial number of BRCA mutations were identified in clinically high risk breast cancer from Middle East region. Identification of the mutation spectrum, prevalence and founder effect in Middle Eastern population facilitates genetic counseling, risk assessment and development of cost-effective screening strategy.

  5. The empirical power of rare variant association methods: results from sanger sequencing in 1,998 individuals.

    Directory of Open Access Journals (Sweden)

    Martin Ladouceur

    2012-02-01

    Full Text Available The role of rare genetic variation in the etiology of complex disease remains unclear. However, the development of next-generation sequencing technologies offers the experimental opportunity to address this question. Several novel statistical methodologies have been recently proposed to assess the contribution of rare variation to complex disease etiology. Nevertheless, no empirical estimates comparing their relative power are available. We therefore assessed the parameters that influence their statistical power in 1,998 individuals Sanger-sequenced at seven genes by modeling different distributions of effect, proportions of causal variants, and direction of the associations (deleterious, protective, or both in simulated continuous trait and case/control phenotypes. Our results demonstrate that the power of recently proposed statistical methods depend strongly on the underlying hypotheses concerning the relationship of phenotypes with each of these three factors. No method demonstrates consistently acceptable power despite this large sample size, and the performance of each method depends upon the underlying assumption of the relationship between rare variants and complex traits. Sensitivity analyses are therefore recommended to compare the stability of the results arising from different methods, and promising results should be replicated using the same method in an independent sample. These findings provide guidance in the analysis and interpretation of the role of rare base-pair variation in the etiology of complex traits and diseases.

  6. Unified approach to hard diffraction

    CERN Document Server

    Peschanski, R

    2001-01-01

    Using a combination of S-Matrix and perturbative QCD properties in the small x_{Bj} regime, we propose a formulation of hard diffraction unifying the partonic (Ingelman-Schlein) Pomeron, Soft Colour Interaction and QCD dipole descriptions.

  7. Unified metamodel of object system

    OpenAIRE

    Oleynik, P. P.

    2015-01-01

    This article describes the unified metamodel of object system which can be used for domain-driven design (DDD) of information system. At the beginning of the work carried out in-depth analysis of existing studies devoted to the organization different metamodels. Metamodel for representing fragments in the figures presented class diagrams of Unified Modeling Language (UML). In the beginning of this article provides a general diagram which displays important associations. Next are separately sh...

  8. Smith Tackles Oakland Unified

    Science.gov (United States)

    Mellon, Ericka

    2011-01-01

    As a 20-something, Anthony "Tony" Smith had fulfilled one dream: playing professional football for the Green Bay Packers and the San Francisco 49ers. Next up, he thought, was law school, but a former mentor reminded him that he is a teacher. Smith never became a classroom teacher, but his background in sports--where he learned the power…

  9. Comprehensive transcriptome assembly of Chickpea (Cicer arietinum L.) using sanger and next generation sequencing platforms: development and applications.

    Science.gov (United States)

    Kudapa, Himabindu; Azam, Sarwar; Sharpe, Andrew G; Taran, Bunyamin; Li, Rong; Deonovic, Benjamin; Cameron, Connor; Farmer, Andrew D; Cannon, Steven B; Varshney, Rajeev K

    2014-01-01

    A comprehensive transcriptome assembly of chickpea has been developed using 134.95 million Illumina single-end reads, 7.12 million single-end FLX/454 reads and 139,214 Sanger expressed sequence tags (ESTs) from >17 genotypes. This hybrid transcriptome assembly, referred to as Cicer arietinumTranscriptome Assembly version 2 (CaTA v2, available at http://data.comparative-legumes.org/transcriptomes/cicar/lista_cicar-201201), comprising 46,369 transcript assembly contigs (TACs) has an N50 length of 1,726 bp and a maximum contig size of 15,644 bp. Putative functions were determined for 32,869 (70.8%) of the TACs and gene ontology assignments were determined for 21,471 (46.3%). The new transcriptome assembly was compared with the previously available chickpea transcriptome assemblies as well as to the chickpea genome. Comparative analysis of CaTA v2 against transcriptomes of three legumes - Medicago, soybean and common bean, resulted in 27,771 TACs common to all three legumes indicating strong conservation of genes across legumes. CaTA v2 was also used for identification of simple sequence repeats (SSRs) and intron spanning regions (ISRs) for developing molecular markers. ISRs were identified by aligning TACs to the Medicago genome, and their putative mapping positions at chromosomal level were identified using transcript map of chickpea. Primer pairs were designed for 4,990 ISRs, each representing a single contig for which predicted positions are inferred and distributed across eight linkage groups. A subset of randomly selected ISRs representing all eight chickpea linkage groups were validated on five chickpea genotypes and showed 20% polymorphism with average polymorphic information content (PIC) of 0.27. In summary, the hybrid transcriptome assembly developed and novel markers identified can be used for a variety of applications such as gene discovery, marker-trait association, diversity analysis etc., to advance genetics research and breeding applications in

  10. Memory materials: a unifying description

    Directory of Open Access Journals (Sweden)

    Massimiliano Di Ventra

    2011-12-01

    Full Text Available There are so many materials properties leading to memory that a unifying description seems impossible. However, it is easy to show that the majority of two-terminal electronic devices based on memory materials and systems, when subject to time-dependent perturbations, behave simply as, or as a combination of, memristors, memcapacitors, and meminductors; namely non-linear circuit elements with memory. This unifying description opens up new venues for digital and analog applications ranging from information storage to biologically-inspired circuits. In this review, interesting research opportunities that emerge from this new perspective will be outlined.

  11. The Simplest Unified Growth Theory

    DEFF Research Database (Denmark)

    Strulik, Holger; Weisdorf, Jacob Louis

    This paper provides a unified growth theory, i.e. a model that explains the very long-run economic and demographic development path of industrialized economies, stretching from the pre-industrial era to present-day and beyond. Making strict use of Malthus' (1798) so-called preventive check...... hypothesis - that fertility rates vary inversely with the price of food - the current study offers a new and straightforward explanation for the demographic transition and the break with the Malthusian era. The current framework lends support to existing unified growth theories and is well in tune...... with historical evidence about structural transformation...

  12. Bioinformatic analysis of ESTs collected by Sanger and pyrosequencing methods for a keystone forest tree species: oak

    Directory of Open Access Journals (Sweden)

    Léger Patrick

    2010-11-01

    Full Text Available Abstract Background The Fagaceae family comprises about 1,000 woody species worldwide. About half belong to the Quercus family. These oaks are often a source of raw material for biomass wood and fiber. Pedunculate and sessile oaks, are among the most important deciduous forest tree species in Europe. Despite their ecological and economical importance, very few genomic resources have yet been generated for these species. Here, we describe the development of an EST catalogue that will support ecosystem genomics studies, where geneticists, ecophysiologists, molecular biologists and ecologists join their efforts for understanding, monitoring and predicting functional genetic diversity. Results We generated 145,827 sequence reads from 20 cDNA libraries using the Sanger method. Unexploitable chromatograms and quality checking lead us to eliminate 19,941 sequences. Finally a total of 125,925 ESTs were retained from 111,361 cDNA clones. Pyrosequencing was also conducted for 14 libraries, generating 1,948,579 reads, from which 370,566 sequences (19.0% were eliminated, resulting in 1,578,192 sequences. Following clustering and assembly using TGICL pipeline, 1,704,117 EST sequences collapsed into 69,154 tentative contigs and 153,517 singletons, providing 222,671 non-redundant sequences (including alternative transcripts. We also assembled the sequences using MIRA and PartiGene software and compared the three unigene sets. Gene ontology annotation was then assigned to 29,303 unigene elements. Blast search against the SWISS-PROT database revealed putative homologs for 32,810 (14.7% unigene elements, but more extensive search with Pfam, Refseq_protein, Refseq_RNA and eight gene indices revealed homology for 67.4% of them. The EST catalogue was examined for putative homologs of candidate genes involved in bud phenology, cuticle formation, phenylpropanoids biosynthesis and cell wall formation. Our results suggest a good coverage of genes involved in these

  13. Comprehensive transcriptome assembly of Chickpea (Cicer arietinum L. using sanger and next generation sequencing platforms: development and applications.

    Directory of Open Access Journals (Sweden)

    Himabindu Kudapa

    Full Text Available A comprehensive transcriptome assembly of chickpea has been developed using 134.95 million Illumina single-end reads, 7.12 million single-end FLX/454 reads and 139,214 Sanger expressed sequence tags (ESTs from >17 genotypes. This hybrid transcriptome assembly, referred to as Cicer arietinumTranscriptome Assembly version 2 (CaTA v2, available at http://data.comparative-legumes.org/transcriptomes/cicar/lista_cicar-201201, comprising 46,369 transcript assembly contigs (TACs has an N50 length of 1,726 bp and a maximum contig size of 15,644 bp. Putative functions were determined for 32,869 (70.8% of the TACs and gene ontology assignments were determined for 21,471 (46.3%. The new transcriptome assembly was compared with the previously available chickpea transcriptome assemblies as well as to the chickpea genome. Comparative analysis of CaTA v2 against transcriptomes of three legumes - Medicago, soybean and common bean, resulted in 27,771 TACs common to all three legumes indicating strong conservation of genes across legumes. CaTA v2 was also used for identification of simple sequence repeats (SSRs and intron spanning regions (ISRs for developing molecular markers. ISRs were identified by aligning TACs to the Medicago genome, and their putative mapping positions at chromosomal level were identified using transcript map of chickpea. Primer pairs were designed for 4,990 ISRs, each representing a single contig for which predicted positions are inferred and distributed across eight linkage groups. A subset of randomly selected ISRs representing all eight chickpea linkage groups were validated on five chickpea genotypes and showed 20% polymorphism with average polymorphic information content (PIC of 0.27. In summary, the hybrid transcriptome assembly developed and novel markers identified can be used for a variety of applications such as gene discovery, marker-trait association, diversity analysis etc., to advance genetics research and breeding

  14. On the History of Unified Field Theories

    Directory of Open Access Journals (Sweden)

    Goenner Hubert F.M.

    2004-01-01

    Full Text Available This article is intended to give a review of the history of the classical aspects of unified field theories in the 20th century. It includes brief technical descriptions of the theories suggested, short biographical notes concerning the scientists involved, and an extensive bibliography. The present first installment covers the time span between 1914 and 1933, i.e., when Einstein was living and working in Berlin - with occasional digressions into other periods. Thus, the main theme is the unification of the electromagnetic and gravitational fields augmented by short-lived attempts to include the matter field described by Schrödinger's or Dirac's equations. While my focus lies on the conceptual development of the field, by also paying attention to the interaction of various schools of mathematicians with the research done by physicists, some prosopocraphical remarks are included.

  15. The Simplest Unified Growth Theory

    DEFF Research Database (Denmark)

    Strulik, Holger; Weisdorf, Jacob Louis

    This paper provides a unified growth theory, i.e. a model that explains the very long-run economic and demographic development path of industrialized economies, stretching from the pre-industrial era to present-day and beyond. Making strict use of Malthus' (1798) so-called preventive check...

  16. Unifying approach to hard diffraction

    CERN Document Server

    Navelet, H

    2001-01-01

    We find a formulation of hard diffraction unifying the partonic (Ingelman-Schlein) Pomeron, Soft Colour Interaction and QCD dipole descriptions. A theoretical interpretation in terms of S-Matrix and perturbative QCD properties in the small x_{Bj} regime is proposed.

  17. On a New Unified Integral

    Indian Academy of Sciences (India)

    Mridula Garg; Shweta Mittal

    2004-05-01

    In the present paper we derive a unified new integral whose integrand contains products of Fox -function and a general class of polynomials having general arguments. A large number of integrals involving various simpler functions follow as special cases of this integral.

  18. Large Unifying Hybrid Supernetwork Model

    Institute of Scientific and Technical Information of China (English)

    LIU; Qiang; FANG; Jin-qing; LI; Yong

    2015-01-01

    For depicting multi-hybrid process,large unifying hybrid network model(so called LUHNM)has two sub-hybrid ratios except dr.They are deterministic hybrid ratio(so called fd)and random hybrid ratio(so called gr),respectively.

  19. 76 FR 19893 - Unified Command Plan 2011

    Science.gov (United States)

    2011-04-08

    ...#0;#0; ] Memorandum of April 6, 2011 Unified Command Plan 2011 Memorandum for the Secretary of... the revised Unified Command Plan. Consistent with title 10, United States Code, section 161(b)(2)...

  20. Unified Hybrid Network Theoretical Model Trilogy

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The first of the unified hybrid network theoretical model trilogy (UHNTF) is the harmonious unification hybrid preferential model (HUHPM), seen in the inner loop of Fig. 1, the unified hybrid ratio is defined.

  1. Unifiability in extensions of K4

    NARCIS (Netherlands)

    Gencer, Ç.; de Jongh, D.

    2009-01-01

    We extend and generalize the work on unifiability of [8]. We give a semantic characterization for unifiability and non-unifiability in the extensions of K4. We apply this in particular to extensions of KD4, GL and K4.3 to obtain a syntactic characterization and give a concrete decision procedure for

  2. Unified capacitance modelling of MOSFETs

    Science.gov (United States)

    Johannessen, O. G.; Fjeldly, T. A.; Ytterdal, T.

    1994-01-01

    A unified physics based capacitance model for MOSFETs suitable for implementation in circuit simulators is presented. This model is based on the charge conserving, so-called Meyer-like approach proposed by Turchetti et al., and utilizes a unified charge control model to assure a continuous description of the MOSFET capacitances both above and below threshold. The capacitances associated with the model are comparable to those of the well-known BSIM model in the above-threshold regime, but it is more precise in the description of near-threshold and subthreshold behaviour. Moreover, the discontinuities at the transitions between the various regimes of operation are removed. The present modelling scheme was implemented in our circuit simulator AIM-Spice, and simulations of the dynamic behaviour of various demanding benchmark circuits clearly reveal its superiority over simulations using the simple Meyer model.

  3. Unified Theory of Fundamental Interactions

    Institute of Scientific and Technical Information of China (English)

    WU Ning

    2003-01-01

    Based on local gauge invariance, four different kinds of fundamental interactions in nature are unified in a theory which has SU(3)C( )SU SU(2)L( )U(1)( )s Gravitational Gauge Group gauge symmetry. In this approach,gravitational field, like electromagnetic field, intermediate gauge field, and gluon field, is represented by gauge potential.Four kinds of fundamental interactions are formulated in the similar manner, and therefore can be unified in a direct or semi-direct product group. The model discussed in this paper is a renormalizable quantum model and can be regarded as an extension of the standard model to gravitational interactions, so it can be used to study quantum effects of gravitational interactions.

  4. Proposal of unified fermion texture

    CERN Document Server

    Królikowski, W

    1998-01-01

    A unified form of mass matrix is proposed for neutrinos, charged leptons, up quarks and down quarks. Some constraints for the parameters involved are tent% atively postulated. Then, the predictions are neatly consistent with available experimental data. Among the predictions are: (i) $ m_\\tau \\simeq 1776.80 $~MeV (with the inputs of $ m_e $ and $ m_\\mu $), (ii) $ m_{\

  5. A New Unified Evolution Equation

    OpenAIRE

    1998-01-01

    WE propose a new unified evolution equation for parton distribution functions appropriate for both large and small Bjorken x. Compared with the Ciafaloni- Catani-Fiorani-Marchesini equation, the cancellation of soft poles between virtual and real gluon emissions is made explicitly without introducing infrared cutoffs, next-to-leading contributions to the Sudakov resummation can be included systematically, and the scales of the running coupling constants are determined unambiguously.

  6. Unified broadcast in sensor networks

    DEFF Research Database (Denmark)

    Hansen, Morten Tranberg; Jurdak, Raja; Kusy, Branislav

    2011-01-01

    to consolidate these broadcasts focus on piggybacking information into existing services but such tight coupling between protocols limits code reuse and interoperability of applications. We present Unified Broadcast (UB) which combines broadcasts from multiple protocols while maintaining a modular architecture......Complex sensor network applications include multiple services such as collection, dissemination, time synchronization, and failure detection protocols. Many of these protocols require local state maintenance through periodic broadcasts which leads to high control overhead. Recent attempts...

  7. Do School Uniforms Fit?

    Science.gov (United States)

    White, Kerry A.

    2000-01-01

    In 1994, Long Beach (California) Unified School District began requiring uniforms in all elementary and middle schools. Now, half of all urban school systems and many suburban schools have uniform policies. Research on uniforms' effectiveness is mixed. Tightened dress codes may be just as effective and less litigious. (MLH)

  8. Very high resolution single pass HLA genotyping using amplicon sequencing on the 454 next generation DNA sequencers: Comparison with Sanger sequencing.

    Science.gov (United States)

    Yamamoto, F; Höglund, B; Fernandez-Vina, M; Tyan, D; Rastrou, M; Williams, T; Moonsamy, P; Goodridge, D; Anderson, M; Erlich, H A; Holcomb, C L

    2015-12-01

    Compared to Sanger sequencing, next-generation sequencing offers advantages for high resolution HLA genotyping including increased throughput, lower cost, and reduced genotype ambiguity. Here we describe an enhancement of the Roche 454 GS GType HLA genotyping assay to provide very high resolution (VHR) typing, by the addition of 8 primer pairs to the original 14, to genotype 11 HLA loci. These additional amplicons help resolve common and well-documented alleles and exclude commonly found null alleles in genotype ambiguity strings. Simplification of workflow to reduce the initial preparation effort using early pooling of amplicons or the Fluidigm Access Array™ is also described. Performance of the VHR assay was evaluated on 28 well characterized cell lines using Conexio Assign MPS software which uses genomic, rather than cDNA, reference sequence. Concordance was 98.4%; 1.6% had no genotype assignment. Of concordant calls, 53% were unambiguous. To further assess the assay, 59 clinical samples were genotyped and results compared to unambiguous allele assignments obtained by prior sequence-based typing supplemented with SSO and/or SSP. Concordance was 98.7% with 58.2% as unambiguous calls; 1.3% could not be assigned. Our results show that the amplicon-based VHR assay is robust and can replace current Sanger methodology. Together with software enhancements, it has the potential to provide even higher resolution HLA typing. Copyright © 2015. Published by Elsevier Inc.

  9. Grand unified theories from superstrings

    CERN Document Server

    Cleaver, G B

    1996-01-01

    I discuss how traditional grand unified theories, which require adjoint (or higher representation) Higgs fields for breaking to the standard model, can be contained within string theory. The status of stringy free fermionic three generation SO(10) SUSY--GUT models is reviewed. Progress in classification of both SO(10)_2 charged and uncharged embeddings and in N=1 spacetime solutions is discussed. Based on talks presented at the Workshop on SUSY Phenomena and SUSY GUTs, Santa Barbara, California, Dec. 7-11, 1995, and at the Orbis Scientiae, Coral Gables, Florida, January 25-28, 1996. To appear in the Proceedings of Orbis Scientiae, 1996.

  10. Unifying suspension and granular rheology.

    Science.gov (United States)

    Boyer, François; Guazzelli, Élisabeth; Pouliquen, Olivier

    2011-10-28

    Using an original pressure-imposed shear cell, we study the rheology of dense suspensions. We show that they exhibit a viscoplastic behavior similarly to granular media successfully described by a frictional rheology and fully characterized by the evolution of the friction coefficient μ and the volume fraction ϕ with a dimensionless viscous number I(v). Dense suspension and granular media are thus unified under a common framework. These results are shown to be compatible with classical empirical models of suspension rheology and provide a clear determination of constitutive laws close to the jamming transition.

  11. Einstein's theory of unified fields

    CERN Document Server

    Tonnelat, Marie Antoinette

    2014-01-01

    First published in1966, here is presented a comprehensive overview of one of the most elusive scientific speculations by the pre-eminent genius of the 20th century. The theory is viewed by some scientists with deep suspicion, by others with optimism, but all agree that it represents an extreme challenge. As the author herself affirms, this work is not intended to be a complete treatise or 'didactic exposition' of the theory of unified fields, but rather a tool for further study, both by students and professional physicists. Dealing with all the major areas of research whic

  12. Sedenion unified theory of gravi-electromagnetism

    Science.gov (United States)

    Chanyal, B. C.

    2014-11-01

    In this paper, we represent 16-component sedenions, the generalization of octonions, which is noncommutative space-time algebra. The sedenions is neither a composition algebra nor a division algebra because it has zero divisors. Here we have formulated the sedenionic unified potential equations, unified fields equations and unified current equations of dyons and gravito-dyons. We have developed the sedenionic unified theory of dyons and gravito-dyons in terms of two eight-potentials leading to the structural symmetry between generalized electromagnetic fields of dyons and generalized gravito-Heavisidian fields of gravito-dyons. Thus we have obtained the sedenionic form of generalized Dirac-Maxwell's equations, unified work-energy theorem (Poynting theorem), generalized unified gravi-electromagnetic force and other quantum equations of dyons and gravito-dyons in simple, compact and consistent way incorporating the non-associativity and non-commutativity of sedenion variables.

  13. Unified symmetry of Vacco dynamical systems

    Institute of Scientific and Technical Information of China (English)

    Li Yuan-Cheng; Jing Hong-Xing; Xia Li-Li; Wang Jing; Hou Qi-Bao

    2007-01-01

    Based on the total time derivative along the trajectory of the time, we study the unified symmetry of Vacco dynamical systems. The definition and the criterion of the unified symmetry for the system are given. Three kinds of conserved quantities, i.e. the Noether conserved quantity, the generalized Hojman conserved quantity and the Mei conserved quantity, are deduced from the unified symmetry. An example is presented to illustrate the results.

  14. Unifying Memory and Database Transactions

    Science.gov (United States)

    Dias, Ricardo J.; Lourenço, João M.

    Software Transactional Memory is a concurrency control technique gaining increasing popularity, as it provides high-level concurrency control constructs and eases the development of highly multi-threaded applications. But this easiness comes at the expense of restricting the operations that can be executed within a memory transaction, and operations such as terminal and file I/O are either not allowed or incur in serious performance penalties. Database I/O is another example of operations that usually are not allowed within a memory transaction. This paper proposes to combine memory and database transactions in a single unified model, benefiting from the ACID properties of the database transactions and from the speed of main memory data processing. The new unified model covers, without differentiating, both memory and database operations. Thus, the users are allowed to freely intertwine memory and database accesses within the same transaction, knowing that the memory and database contents will always remain consistent and that the transaction will atomically abort or commit the operations in both memory and database. This approach allows to increase the granularity of the in-memory atomic actions and hence, simplifies the reasoning about them.

  15. Yukawa-unified natural supersymmetry

    CERN Document Server

    Baer, Howard; Kulkarni, Suchita

    2012-01-01

    Previous work on t-b-\\tau Yukawa-unified supersymmetry, as expected from SUSY GUT theories based on the gauge group SO(10), tended to have exceedingly large electroweak fine-tuning (EWFT). Here, we examine supersymmetric models where we simultaneously require low EWFT ("natural SUSY") and a high degree of Yukawa coupling unification, along with a light Higgs scalar with m_h\\sim125 GeV. As Yukawa unification requires large tan\\beta\\sim50, while EWFT requires rather light third generation squarks and low \\mu\\sim100-250 GeV, B-physics constraints from BR(B\\to X_s\\gamma) and BR(B_s\\to \\mu+\\mu-) can be severe. We are able to find models with EWFT \\Delta\\lesssim 50-100 (better than 1-2% EWFT) and with Yukawa unification as low as R_yuk\\sim1.3 (30% unification) if B-physics constraints are imposed. This may be improved to R_yuk\\sim1.2 if additional small flavor violating terms conspire to improve accord with B-constraints. We present several Yukawa-unified natural SUSY (YUNS) benchmark points. LHC searches will be a...

  16. Charter Schools and Market Segmentation

    Science.gov (United States)

    Batie, Michael

    2009-01-01

    This dissertation was undertaken to examine the effect(s) of charter school marketing on the Los Angeles Unified School District (LAUSD) education landscape with respect to the stratification of charter schools. Information from four sources: school websites, a survey of charter school parents, existing online statistics and data, and various…

  17. Charter Schools and Market Segmentation

    Science.gov (United States)

    Batie, Michael

    2009-01-01

    This dissertation was undertaken to examine the effect(s) of charter school marketing on the Los Angeles Unified School District (LAUSD) education landscape with respect to the stratification of charter schools. Information from four sources: school websites, a survey of charter school parents, existing online statistics and data, and various…

  18. School Districts - MO 2010 TIGER Census Unified School Districts (SHP)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — The TIGER/Line Files are shapefiles and related database files (.dbf) that are an extract of selected geographic and cartographic information from the U.S. Census...

  19. Screening for EGFR mutations in lung cancer by a novel real-time PCR with double-loop probe and Sanger DNA sequencing%特异引物双扩增实时PCR法和Sanger DNA测序法检测肺癌组织中表皮生长因子受体基因突变

    Institute of Scientific and Technical Information of China (English)

    张海萍; 阮力; 郑立谟; 白冬雨; 张海芳; 廖永强; 丁毅

    2013-01-01

    Objective To map the frequency and types of EGFR gene mutations present in lung cancer tissues.To evaluate the clinical applicability of a novel real-time double-loop probe PCR of which the ADx-EGFR kit is based,and to compare its performance with traditional Sanger DNA sequencing in the detection of somatic mutations of tumor genes.Methods A total of 208 formalin-fixed paraffin-embedded (FFPE) tumor samples were tested.Genomic DNA of the tissue samples was extracted and purified,and subjected to both traditional PCR amplification,Sanger sequencing of EGFR gene in exon 18,19,20,21,and ADx's EGFR mutation detection kit.The mutation rates for EGFR gene in exon 18,19,20,21,as well as the frequency of each mutation detected by the two methods,were analyzed.Results The traditional Sanger DNA sequencing technique was successfully performed in 196 out of 208 (94.2%) lung cancer samples,and 22 samples (11.2%) showed EGFR gene mutations.ADx-EGFR kit was successfully used in the lung cancers of all of the 208 cases (100.0%),and 40 samples (19.2%) showed mutations.In the lung cancer samples analyzed,mutations were mainly detected in the exon 19 and exon 21 L858R point mutation,i.e.4.8% (10/208) and 11.6% (23/208) of total mutations,respectively,and the remaining mutations were rare.Conclusions The success rate of ADx-EGFR real-time PCR for formalin-fixed and paraffin-embedded tissues samples is significantly higher than that of Sanger sequencing (P <0.01).There are significant differences between the two methods.ADx-EGFR real-time PCR shows a much higher successful detection rate and mutation rate of lung cancer tissues compared with that of Sanger sequencing.As a result,the real-time PCR with ADx-EGFR kit is proved to have a good clinical applicability and a strong advantage over the traditional Sanger DNA sequencing.It is an effective and reliable tool for clinical screening of somatic gene mutations in tumors.%目的 探讨特异引物双环探针扩增实

  20. A comparison of parallel pyrosequencing and sanger clone-based sequencing and its impact on the characterization of the genetic diversity of HIV-1.

    Directory of Open Access Journals (Sweden)

    Binhua Liang

    Full Text Available BACKGROUND: Pyrosequencing technology has the potential to rapidly sequence HIV-1 viral quasispecies without requiring the traditional approach of cloning. In this study, we investigated the utility of ultra-deep pyrosequencing to characterize genetic diversity of the HIV-1 gag quasispecies and assessed the possible contribution of pyrosequencing technology in studying HIV-1 biology and evolution. METHODOLOGY/PRINCIPAL FINDINGS: HIV-1 gag gene was amplified from 96 patients using nested PCR. The PCR products were cloned and sequenced using capillary based Sanger fluorescent dideoxy termination sequencing. The same PCR products were also directly sequenced using the 454 pyrosequencing technology. The two sequencing methods were evaluated for their ability to characterize quasispecies variation, and to reveal sites under host immune pressure for their putative functional significance. A total of 14,034 variations were identified by 454 pyrosequencing versus 3,632 variations by Sanger clone-based (SCB sequencing. 11,050 of these variations were detected only by pyrosequencing. These undetected variations were located in the HIV-1 Gag region which is known to contain putative cytotoxic T lymphocyte (CTL and neutralizing antibody epitopes, and sites related to virus assembly and packaging. Analysis of the positively selected sites derived by the two sequencing methods identified several differences. All of them were located within the CTL epitope regions. CONCLUSIONS/SIGNIFICANCE: Ultra-deep pyrosequencing has proven to be a powerful tool for characterization of HIV-1 genetic diversity with enhanced sensitivity, efficiency, and accuracy. It also improved reliability of downstream evolutionary and functional analysis of HIV-1 quasispecies.

  1. Disagreement in genotyping results of drug resistance alleles of the Plasmodium falciparum dihydrofolate reductase (Pfdhfr) gene by allele-specific PCR (ASPCR) assays and Sanger sequencing.

    Science.gov (United States)

    Sharma, Divya; Lather, Manila; Dykes, Cherry L; Dang, Amita S; Adak, Tridibes; Singh, Om P

    2016-01-01

    The rapid spread of antimalarial drug resistance in Plasmodium falciparum over the past few decades has necessitated intensive monitoring of such resistance for an effective malaria control strategy. P. falciparum dihydropteroate synthase (Pfdhps) and P. falciparum dihydrofolate reductase (Pfdhfr) genes act as molecular markers for resistance against the antimalarial drugs sulphadoxine and pyrimethamine, respectively. Resistance to pyrimethamine which is used as a partner drug in artemisinin combination therapy (ACT) is associated with several mutations in the Pfdhfr gene, namely A16V, N51I, C59R, S108N/T and I164L. Therefore, routine monitoring of Pfdhfr-drug-resistant alleles in a population may help in effective drug resistance management. Allele-specific PCR (ASPCR) is one of the commonly used methods for molecular genotyping of these alleles. In this study, we genotyped 55 samples of P. falciparum for allele discrimination at four codons of Pfdhfr (N51, C59, S108 and I164) by ASPCR using published methods and by Sanger's DNA sequencing method. We found that the ASPCR identified a significantly higher number of mutant alleles as compared to the DNA sequencing method. Such discrepancies arise due to the non-specificity of some of the allele-specific primer sets and due to the lack of sensitivity of Sanger's DNA sequencing method to detect minor alleles present in multiple clone infections. This study reveals the need of a highly specific and sensitive method for genotyping and detecting minor drug-resistant alleles present in multiple clonal infections.

  2. Unifying physical concepts of reality

    Energy Technology Data Exchange (ETDEWEB)

    Gilbert, T.L.

    1983-08-01

    Physics may be characterized as the science of matter and energy. It anchors the two ends of the frontiers of science: the frontier of the very small and the frontier of the very large. All of the phenomena that we observe and study at the frontiers of science - all external experiences - are manifestations of matter and energy. One may, therefore, use physics to exemplify both the diversity and unity of science. This theme will be developed in two separate examples: first by sketching, very briefly, the historical origins of frontiers of the very small and very large and the converging unity of these two frontiers; and then by describing certain unifying concepts that play a central role in physics and provide a framework for relating developments in different sciences.

  3. Towards a Unified Programming Language

    DEFF Research Database (Denmark)

    Madsen, Ole Lehrmann

    2000-01-01

    find that the languages of the future should integrate the best available concepts and constructs in such a way that the programmer does not think of multiple paradigms when using a given language. In this paper, we describe to what extent the BETA language has been successful in obtaining a unified......The goal of research in programming languages should be to develop languages that integrates the best of concepts and constructs from the various programming paradigms. We do not argue for a multi-paradigm language, where the programmer alternates between the different paradigms/styles. Instead, we...... style and where more research is needed. In addition to traditional paradigms such as object-oriented-, imperative-functional- and logic programming, we also discuss concurrent programming and prototype-based programming. We discuss language features such as the BETA pattern construct, virtual...

  4. A unifying process capability metric

    Directory of Open Access Journals (Sweden)

    John Jay Flaig

    2009-07-01

    Full Text Available A new economic approach to process capability assessment is presented, which differs from the commonly used engineering metrics. The proposed metric consists of two economic capability measures – the expected profit and the variation in profit of the process. This dual economic metric offers a number of significant advantages over other engineering or economic metrics used in process capability analysis. First, it is easy to understand and communicate. Second, it is based on a measure of total system performance. Third, it unifies the fraction nonconforming approach and the expected loss approach. Fourth, it reflects the underlying interest of management in knowing the expected financial performance of a process and its potential variation.

  5. Unifying Theories of Mobile Channels

    Directory of Open Access Journals (Sweden)

    Gerard Ekembe Ngondi

    2016-06-01

    Full Text Available In this paper we present the denotational semantics for channel mobility in the Unifying Theories of Programming (UTP semantics framework. The basis for the model is the UTP theory of reactive processes (precisely, the UTP semantics for Communicating Sequential Processes (CSP, which is slightly extended to allow the mobility of channels: the set of actions in which a process is authorised to participate, originally static or constant (set during the process's definition, is now made dynamic or variable: it can change during the process's execution. A channel is thus moved around by communicating it via other channels and then allowing the receiving process to extend its alphabet with the received channel. New healthiness conditions are stated to ensure an appropriate use of mobile channels.

  6. Harmonious Unifying Hybrid Preferential Supernetwork Model

    Institute of Scientific and Technical Information of China (English)

    LIU; Qiang; FANG; Jin-qing; LI; Yong

    2015-01-01

    The basic concepts and methods for harmonious unifying hybrid preferential model(HUHPM)are based on random preferential attachment(RPA)mixed with deterministic preferential attachment(DPA),so there is only one unified hybrid ratio dr,which is defined as:

  7. Toward a Unified AGN Structure

    Science.gov (United States)

    Kazanas, Demosthenes; Fukumura, Keigo; Shrader, Chris; Behar, Ehud; Contopoulosa, Ioannis

    2012-01-01

    We present a unified model for the structure and appearance of accretion powered sources across their entire luminosity range from galactic X-ray binaries (XRB) to luminous quasars, with emphasis on AG N and their phenomenology. Central to this model is the notion of MHD winds launched by the accretion disks that power these objects. These winds provide the matter that manifests as blueshifted absorption features in the UV and X-ray spectra of a large fraction of these sources; furthermore, their density distribution in the poloidal plane determines their "appearance" (i.e. the column and velocity structure of these absorption features and the obscuration of the continuum source) as a function of the observer inclination angle (a feature to which INTEGRAL has made significant contributions). This work focuses on just the broadest characteristics of these objects; nonetheless, it provides scaling laws that allow one to reproduce within this model the properties of objects extending in luminosity from luminous quasars to XRBs. Our general conclusion is that the AGN phenomenology can be accounted for in terms of three parameters: The wind maSS flux in units of the Eddington value, m(dot), the observers' inclination angle Theta and the logarithmic slope between the 0/UV and X-ray fluxes alpha(sub ox); however because of a correlation between alpha(sub ox) and UV luminosity the number of significant parameters is two. The AGN correlations implied by this model appear to extend to and consistent with the XRB phenomenology, suggesting the presence of a truly unified underlying structure for accretion powered sources.

  8. Yukawa-unified natural supersymmetry

    Science.gov (United States)

    Baer, Howard; Kraml, Sabine; Kulkarni, Suchita

    2012-12-01

    Previous work on t - b - τ Yukawa-unified supersymmetry, as expected from SUSY GUT theories based on the gauge group SO(10), tended to have exceedingly large electroweak fine-tuning (EWFT). Here, we examine supersymmetric models where we simultaneously require low EWFT ("natural SUSY") and a high degree of Yukawa coupling unification, along with a light Higgs scalar with m h 125 GeV. As Yukawa unification requires large tan β 50, while EWFT requires rather light third generation squarks and low μ ≈ 100 - 250 GeV, B-physics constraints from BR( B → X s γ) and BR( B s → μ + μ -) can be severe. We are able to find models with EWFT Δ ≲ 50 - 100 (better than 1-2% EWFT) and with Yukawa unification as low as R yuk 1.2 (20% unification). The unification is lessened to R yuk 1.3 when B-physics constraints are imposed. We present several Yukawa-unified natural SUSY (YUNS) benchmark points. LHC searches will be able to access gluinos in the lower 1 - 2 TeV portion of their predicted mass range although much of YUNS parameter space may lie beyond LHC14 reach. If heavy Higgs bosons can be accessed at a high rate, then the rare H, A → μ + μ - decay might allow a determination of tan β 50 as predicted by YUNS models. Finally, the predicted light higgsinos should be accessible to a linear e + e - collider with sqrt{s}˜ 0.5 TeV.

  9. Seagrass from Unified Florida Reef Tract Map (NODC Accession 0123059)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset is a subset of the Unified Map representing Seagrass areas. Version 1.1 - December 2013. The Unified Florida Reef Tract Map (Unified Reef Map) provides...

  10. A unified theory of superconductivity

    CERN Document Server

    Huang, Xiuqing

    2008-01-01

    In this work, we argue that the phonon-mediated BCS theory may be incorrect. Two kinds of glues, pairing (pseudogap) glue and superconducting glue, are suggested based on a real space Coulomb confinement effect. The scenarios provide a unified explanation of the pairing symmetry, pseudogap and superconducting states, spin--charge stripe order, magic doping fractions and vortex structures in conventional and unconventional (the high-Tc cuprates, MgB2 and the newly-discovered Fe-based family) superconductors. The theory agrees with the existence of a pseudogap in high-temperature superconductors, while no pseudogap feature could be observed in MgB2, iron-based and most of the conventional superconductors. Our results indicate that the superconducting phase can coexist with a triangular vortex lattice in pure MgB2 single crystal with a charge carrier density n=1.49*10^22/cm3. For iron-based superconductors, the relationship between the superconducting vortex phases and the optimal doping levels are analytically ...

  11. Unifying evolutionary and network dynamics

    Science.gov (United States)

    Swarup, Samarth; Gasser, Les

    2007-06-01

    Many important real-world networks manifest small-world properties such as scale-free degree distributions, small diameters, and clustering. The most common model of growth for these networks is preferential attachment, where nodes acquire new links with probability proportional to the number of links they already have. We show that preferential attachment is a special case of the process of molecular evolution. We present a single-parameter model of network growth that unifies varieties of preferential attachment with the quasispecies equation (which models molecular evolution), and also with the Erdős-Rényi random graph model. We suggest some properties of evolutionary models that might be applied to the study of networks. We also derive the form of the degree distribution resulting from our algorithm, and we show through simulations that the process also models aspects of network growth. The unification allows mathematical machinery developed for evolutionary dynamics to be applied in the study of network dynamics, and vice versa.

  12. Negligencia en la Educacion de Estudiantes Mexico-Americanos en el Distrito Escolar Unificado Lucia Mar, Pismo Beach, California. (Educational Neglect of Mexican-American Students in Lucia Mar Unified School District, Pismo Beach, California.)

    Science.gov (United States)

    California State Advisory Committee to the United States Commission on Civil Rights.

    California State Advisory Committee (SAC) of the U.S. Commission on Civil Rights held hearings in Santa Maria, California (May 20, 1972) to collect information on civil rights problems of Mexican American students in the Lucia Mar School District. Major issues were community complaints about the arrest of 26 Mexican American students and some…

  13. Unified Approach in the DSS Development Process

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available The structure of today's decision support environment become very complex due to new generation of Business Intelligence applications and technologies like Data Warehouse, OLAP (On Line Analytical Processing and Data Mining. In this respect DSS development process are not simple and needs an adequate methodology or framework able to manage different tools and platforms to achieve manager's requirements. The DSS development process must be view like a unified and iterative set of activities and operations. The new techniques based on Unified Process (UP methodology and UML (Unified Modeling Language it seems to be appropriate for DSS development using prototyping and RAD (Rapid Application Development techniques. In this paper we present a conceptual framework for development and integrate Decision Support Systems using Unified Process Methodology and UML.

  14. A unified approach to the Painleve Transcendents

    OpenAIRE

    2016-01-01

    We utilise a recent approach via the so-called re-scaling method to derive a unified and comprehensive theory of the solutions to Painleve's differential equations (I), (II) and (IV), with emphasis on the most elaborate equation (IV).

  15. Exhaustivity and intonation: a unified theory

    NARCIS (Netherlands)

    Westera, M.

    2017-01-01

    This dissertation presents a precise, unified and explanatory theory of human conversation, centered on two broad phenomena: exhaustivity implications and intonational meaning. In a nutshell: (i) speakers have two types of communicative intentions, namely information sharing and attention sharing, (

  16. Some Representations of Unified Voigt Functions

    Institute of Scientific and Technical Information of China (English)

    M. KAMARUJJAMA; Dinesh SINGH

    2005-01-01

    The authors derive a set of unified representations of the Voigt functions in terms of familiar special functions of Mathematical Physics. Some deductions from these representations are also considered.

  17. A Unified Framework for Systematic Model Improvement

    DEFF Research Database (Denmark)

    Kristensen, Niels Rode; Madsen, Henrik; Jørgensen, Sten Bay

    2003-01-01

    A unified framework for improving the quality of continuous time models of dynamic systems based on experimental data is presented. The framework is based on an interplay between stochastic differential equation (SDE) modelling, statistical tests and multivariate nonparametric regression...

  18. Unified Data Model for Biological Data

    Directory of Open Access Journals (Sweden)

    Muhammad Idrees

    2014-07-01

    Full Text Available A data model empowers us to store, retrieve and manipulate data in a unified way. We consider the biological data consists of DNA (De-Oxyribonucleic Acid, RNA (Ribonucleic Acid and protein structures. In our Bioinformatics Lab (Bioinformatics Lab, Alkhawarizmi Institute of Computer Science, University of Engineering & Technology, Lahore, Pakistan, we have already proposed two data models for DNA and protein structures individually. In this paper, we propose a unified data model by using the data models of TOS (Temporal Object Oriented System after making some necessary modifications to this data model and our already proposed the two data models. This proposed unified data model can be used for the modeling and maintaining the biological data (i.e. DNA, RNA and protein structures, in a single unified way

  19. KEAMANAN JARINGAN MENGGUNAKAN UNIFIED THREAT MANAGEMENT PADA SERVER BERBASISKAN LINUX

    Directory of Open Access Journals (Sweden)

    Bambang Heru

    2007-05-01

    Full Text Available UTM is an application which integrated many security features become a single hardware platform. The reasonbehind this research is to build a system that protects the network in St. Bellarminus school. Research method that hasbeen used in this research is spiral method, whereas the development of the application is continues and can be modifiedeasily if there is new version of the security tools implemented in the application, or if there is a better security tools to beused. The outcome of the system is very good, because it can protects the network: cross-platform firewall, IntrusionDetection System, Proxy Server, email protection against virus and spam. In conclusion, the application can producehigh effectiveness with low cost and this application is very useful in monitoring and configuring the network in St.Bellarminus school.Keywords: security network, unified threat management, anti virus, server, proxy, firewall

  20. Unified Dark Matter Scalar Field Models

    Directory of Open Access Journals (Sweden)

    Daniele Bertacca

    2010-01-01

    of a single scalar field accounts for a unified description of the Dark Matter and Dark Energy sectors, dubbed Unified Dark Matter (UDM models. In this framework, we consider the general Lagrangian of -essence, which allows to find solutions around which the scalar field describes the desired mixture of Dark Matter and Dark Energy. We also discuss static and spherically symmetric solutions of Einstein's equations for a scalar field with noncanonical kinetic term, in connection with galactic halo rotation curves.

  1. Unified characterisations of resolution hardness measures

    OpenAIRE

    Beyersdorff, O; Kullmann, O.

    2014-01-01

    Various "hardness" measures have been studied for resolution, providing theoretical insight into the proof complexity of resolution and its fragments, as well as explanations for the hardness of instances in SAT solving. In this paper we aim at a unified view of a number of hardness measures, including different measures of width, space and size of resolution proofs. Our main contribution is a unified game-theoretic characterisation of these measures. As consequences we obtain new relations b...

  2. Proposal of Unified Fermion Texture

    Science.gov (United States)

    Krolikowski, W.

    1998-03-01

    unified form of mass matrix is proposed for neutrinos, charged leptons, up quarks and down quarks. Some constraints for the parameters involved are tentatively postulated. Then, the predictions are neatly consistent with available experimental data. Among the predictions are: (i) mτ ~1776.80 MeV (with the inputs of me and mμ ), (ii) mν_0 ≪ mν_1~(0.6 to )× 10-2 eV and mν_2~ (0.2 to 1)× 10-1 eV (with the atmospheric-neutrino inputs of |mν_22 - mν_12| × (0.0003 to 0.01) eV2 and the νμ → ντ oscillation amplitude × 0.8), and also ( iii) ms ~270 MeV, |Vub/Vcb| ~0.082 and argVub ~-640 (with the inputs of mc = 1.3 GeV, mb = 4.5 GeV, |Vus| = 0.221 and |Vcb| = 0.041, where mu ≪ mc ≪ mt and md ≪ ms ≪ mb ). All elements of the Cabibbo--Kobayashi--Maskawa matrix are evaluated. All elements of its lepton counterpart are calculated up to an unknown phase (Appendix B). Some items related to dynamical aspects of the proposed fermion ``texture'' are briefly commented on (Appendix A). In particular, the notion of a novel dark matter, free of any Standard Model interactions (and their supersymmetric variants), appears in the case of preon option.

  3. Sanger Sequencing for BRCA1 c.68_69del, BRCA1 c.5266dup and BRCA2 c.5946del Mutation Screen on Pap Smear Cytology Samples.

    Science.gov (United States)

    Lee, Sin Hang; Zhou, Shaoxia; Zhou, Tianjun; Hong, Guofan

    2016-02-08

    Three sets of polymerase chain reaction (PCR) primers were designed for heminested PCR amplification of the target DNA fragments in the human genome which include the site of BRCA1 c.68_69del, BRCA1 c.5266dup and BRCA2 c.5946del respectively, to prepare the templates for direct Sanger sequencing screen of these three founder mutations. With a robust PCR mixture, crude proteinase K digestate of the fixed cervicovaginal cells in the liquid-based Papanicolaou (Pap) cytology specimens can be used as the sample for target DNA amplification without pre-PCR DNA extraction, purification and quantitation. The post-PCR products can be used directly as the sequencing templates without further purification or quantitation. By simplifying the frontend procedures for template preparation, the cost for screening these three founder mutations can be reduced to about US $200 per test when performed in conjunction with human papillomavirus (HPV) assays now routinely ordered for cervical cancer prevention. With this projected price structure, selective patients in a high-risk population can be tested and each provided with a set of DNA sequencing electropherograms to document the absence or presence of these founder mutations in her genome to help assess inherited susceptibility to breast and ovarian cancer in this era of precision molecular personalized medicine.

  4. Sanger Sequencing for BRCA1 c.68_69del, BRCA1 c.5266dup and BRCA2 c.5946del Mutation Screen on Pap Smear Cytology Samples

    Directory of Open Access Journals (Sweden)

    Sin Hang Lee

    2016-02-01

    Full Text Available Three sets of polymerase chain reaction (PCR primers were designed for heminested PCR amplification of the target DNA fragments in the human genome which include the site of BRCA1 c.68_69del, BRCA1 c.5266dup and BRCA2 c.5946del respectively, to prepare the templates for direct Sanger sequencing screen of these three founder mutations. With a robust PCR mixture, crude proteinase K digestate of the fixed cervicovaginal cells in the liquid-based Papanicolaou (Pap cytology specimens can be used as the sample for target DNA amplification without pre-PCR DNA extraction, purification and quantitation. The post-PCR products can be used directly as the sequencing templates without further purification or quantitation. By simplifying the frontend procedures for template preparation, the cost for screening these three founder mutations can be reduced to about US $200 per test when performed in conjunction with human papillomavirus (HPV assays now routinely ordered for cervical cancer prevention. With this projected price structure, selective patients in a high-risk population can be tested and each provided with a set of DNA sequencing electropherograms to document the absence or presence of these founder mutations in her genome to help assess inherited susceptibility to breast and ovarian cancer in this era of precision molecular personalized medicine.

  5. Proposal of unified fermion texture

    Energy Technology Data Exchange (ETDEWEB)

    Krolikowski, W. [Institute of Theoretical Physics, Warsaw University, Warsaw (Poland)

    1998-03-01

    A unified form of mass matrix is proposed for neutrinos, charged leptons, up quarks and down quarks. Some constraints for the parameters involved are tentatively postulated. Then, the predictions are neatly consistent with available experimental data. Among the predictions are: (i) m{sub {tau}} {approx_equal} 1776.80 MeV (with the inputs of m{sub e} and m{sub {mu}}), (ii) m{sub {nu}0}<

  6. Highly sensitive KRAS mutation detection from formalin-fixed paraffin-embedded biopsies and circulating tumour cells using wild-type blocking polymerase chain reaction and Sanger sequencing.

    Science.gov (United States)

    Huang, Meggie Mo Chao; Leong, Sai Mun; Chua, Hui Wen; Tucker, Steven; Cheong, Wai Chye; Chiu, Lily; Li, Mo-Huang; Koay, Evelyn Siew-Chuan

    2014-08-01

    Among patients with colorectal cancer (CRC), KRAS mutations were reported to occur in 30-51 % of all cases. CRC patients with KRAS mutations were reported to be non-responsive to anti-epidermal growth factor receptor (EGFR) monoclonal antibody (MoAb) treatment in many clinical trials. Hence, accurate detection of KRAS mutations would be critical in guiding the use of anti-EGFR MoAb therapies in CRC. In this study, we carried out a detailed investigation of the efficacy of a wild-type (WT) blocking real-time polymerase chain reaction (PCR), employing WT KRAS locked nucleic acid blockers, and Sanger sequencing, for KRAS mutation detection in rare cells. Analyses were first conducted on cell lines to optimize the assay protocol which was subsequently applied to peripheral blood and tissue samples from patients with CRC. The optimized assay provided a superior sensitivity enabling detection of as little as two cells with mutated KRAS in the background of 10(4) WT cells (0.02 %). The feasibility of this assay was further investigated to assess the KRAS status of 45 colorectal tissue samples, which had been tested previously, using a conventional PCR sequencing approach. The analysis showed a mutational discordance between these two methods in 4 of 18 WT cases. Our results present a simple, effective, and robust method for KRAS mutation detection in both paraffin embedded tissues and circulating tumour cells, at single-cell level. The method greatly enhances the detection sensitivity and alleviates the need of exhaustively removing co-enriched contaminating lymphocytes.

  7. Expanding the mutation spectrum in 130 probands with ARPKD: identification of 62 novel PKHD1 mutations by sanger sequencing and MLPA analysis.

    Science.gov (United States)

    Melchionda, Salvatore; Palladino, Teresa; Castellana, Stefano; Giordano, Mario; Benetti, Elisa; De Bonis, Patrizia; Zelante, Leopoldo; Bisceglia, Luigi

    2016-09-01

    Autosomal recessive polycystic kidney disease (ARPKD) is a rare severe genetic disorder arising in the perinatal period, although a late-onset presentation of the disease has been described. Pulmonary hypoplasia is the major cause of morbidity and mortality in the newborn period. ARPKD is caused by mutations in the PKHD1 (polycystic kidney and hepatic disease 1) gene that is among the largest human genes. To achieve a molecular diagnosis of the disease, a large series of Italian affected subjects were recruited. Exhaustive mutation analysis of PKHD1 gene was carried out by Sanger sequencing and multiple ligation probe amplification (MLPA) technique in 110 individuals. A total of 173 mutations resulting in a detection rate of 78.6% were identified. Additional 20 unrelated patients, in whom it was not possible to analyze the whole coding sequence, have been included in this study. Taking into account the total number (n=130) of this cohort of patients, 107 different types of mutations have been detected in 193 mutated alleles. Out of 107 mutations, 62 were novel: 11 nonsense, 6 frameshift, 7 splice site mutations, 2 in-frame deletions and 2 multiexon deletion detected by MLPA. Thirty-four were missense variants. In conclusion, our report expands the spectrum of PKHD1 mutations and confirms the heterogeneity of this disorder. The population under study represents the largest Italian ARPKD cohort reported to date. The estimated costs and the time invested for molecular screening of genes with large size and allelic heterogeneity such as PKHD1 demand the use of next-generation sequencing (NGS) technologies for a faster and cheaper screening of the affected subjects.

  8. Prospects of a Unified Management System

    DEFF Research Database (Denmark)

    Jørgensen, Tine Herreborg; Simonsen, Gorm

    2002-01-01

    In this article, the trend among management systems towards a common structure and the inclusion of additional areas of corporate concern (quality, environment, occupational health and safety and social responsibility) is outlined. The article suggests that a large part of the work associated...... that the company could wish to include in their management system and possibly have certified. It is estimated that such a unified management system would contribute to synergy between the activities related to each area of concern, resulting in a more careful and efficient treatment of the increasing number...... with implementing and maintaining standardised management systems can be rationalised by developing a ?unified system?. The unified system is proposed to consist of a common basic standard of general managerial methodology expandable with supplements, which are related to the specific areas of concern...

  9. Spherical collapse for unified dark matter models

    CERN Document Server

    Caramês, Thiago R P; Velten, Hermano E S

    2014-01-01

    We study the non-linear spherical "top hat" collapse for Chaplygin and viscous unified cosmologies. The term unified refers to models where dark energy and dark matter are replaced by one single component. For the generalized Chaplygin gas (GCG) we extend previous results of [R. A. A. Fernandes {\\it et al}. Physical Review D 85, 083501 (2012)]. We discuss the differences at non-linear level between the GCG with $\\alpha=0$ and the $\\Lambda$CDM model. We show that both are indeed different. The bulk viscous model which differs from the GCG due to the existence of non-adiabatic perturbations is also studied. In this case, the clustering process is in general suppressed and the viable parameter space of the viscous model that accelerates the background expansion does not lead to collapsed structures. This result challenges the viability of unified viscous models.

  10. Phenomenology of SU(5) finite unified theories

    Energy Technology Data Exchange (ETDEWEB)

    Heinemeyer, S [Instituto de Fisica de Cantabria (CSIC-UC), Edificio Juan Jorda, Avda. de Los Castros s/n, 39005 Santander (Spain); Mondragon, M [Inst. de Fisica, Universidad Nacional Autonoma de Mexico, Apdo. Postal 20-364, Mexico 01000 D.F. (Mexico); Zoupanos, G, E-mail: heinemey@mail.cern.c, E-mail: myriam@fisica.unam.m, E-mail: zoupanos@mail.cern.c [Physics Department, National Technical University of Athens, Zografou Campus: Heroon Polytechniou 9, 15780 Zografou, Athens (Greece)

    2009-06-01

    Finite Unified Theories (FUTs) are N = 1 supersymmetric Grand Unified Theories (GUTs) which can be made finite to all-loop orders, leading to a large reduction in the number of free parameters. We confront the predictions of SU(5) FUTs with the top and bottom quark masses, which allows us to discriminate among different models. We include further low-energy phenomenology constraints, such as B physics observables, the bound on the SM Higgs mass and the cold dark matter density, and then are able to make predictions for the lightest Higgs boson mass and the sparticle spectrum.

  11. A Unified Approach to Generalized Stirling Functions

    Institute of Scientific and Technical Information of China (English)

    Tianxiao HE

    2012-01-01

    Here presented is a unified approach to generalized Stirling functions by using generalized factorial functions,k-Gamma functions,generalized divided difference,and the unified expression of Stirling numbers defined in[16].Previous well-known Stirling functions introduced by Butzer and Hauss[4],Butzer,Kilbas,and Trujilloet[6]and others are included as particular cases of our generalization.Some basic properties related to our general pattern such as their recursive relations,generating functions,and asymptotic properties are discussed,which extend the corresponding results about the Stirling numbers shown in[21]to the defined Stirling functions.

  12. Toward a Unified View of Cognitive Control

    NARCIS (Netherlands)

    Salvucci, Dario D.; Taatgen, Niels A.

    2011-01-01

    Allen Newell (1973) once observed that psychology researchers were playing "twenty questions with nature," carving up human cognition into hundreds of individual phenomena but shying away from the difficult task of integrating these phenomena with unifying theories. We argue that research on cogniti

  13. Unified Modern Mathematics, Course 3, Teachers Commentary.

    Science.gov (United States)

    Secondary School Mathematics Curriculum Improvement Study, New York, NY.

    This commentary is to be used with "Unified Modern Mathematics, Course III." Statements of specific purposes and goals of each section of every chapter of Course III are included in the "Commentary." Also included are suggestions for teaching concepts presented in each section; time estimates for each section; suggested instructional aids for…

  14. Unified Modern Mathematics, Course 1, Teachers Commentary.

    Science.gov (United States)

    Secondary School Mathematics Curriculum Improvement Study, New York, NY.

    This commentary is designed for use with "Unified Modern Mathematics, Course I," Parts 1 and 2. Included in the commentary are statements of the specific purposes and goals of each section of every chapter, suggestions for teaching the concepts presented in each section, time estimates for each section, suggested instructional aids for presenting…

  15. Unified Modern Mathematics, Course 2, Teachers Commentary.

    Science.gov (United States)

    Secondary School Mathematics Curriculum Improvement Study, New York, NY.

    This commentary is designed for use with "Unified Modern Mathematics, Course II," Parts 1 and 2. As in the commentary for "Course I," statements of the specific purposes and goals of each section of every chapter are presented. Also included are suggestions for teaching the concepts presented in each section, time estimates for each section,…

  16. Unifying Quantitative Methodology in Social Research.

    Science.gov (United States)

    Willson, Victor L.

    A case is made for representing quantitative methods in use in the social sciences within a unified framework based on structural equation methodology (SEM). Most of the methods now in use are shown in their SEM representation. It is suggested that the visual and verbal representations of SEM are of most use, while specific estimation and…

  17. A Unified Introduction to Ordinary Differential Equations

    Science.gov (United States)

    Lutzer, Carl V.

    2006-01-01

    This article describes how a presentation from the point of view of differential operators can be used to (partially) unify the myriad techniques in an introductory course in ordinary differential equations by providing students with a powerful, flexible paradigm that extends into (or from) linear algebra. (Contains 1 footnote.)

  18. A unified theory in higher dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Kapetanakis, D. (National Research Centre for the Physical Sciences Democritos, Athens (Greece)); Zoupanos, G. (European Organization for Nuclear Research, Geneva (Switzerland))

    1990-10-11

    We present a grand unified model defined in ten dimensions and based on the group SO(13). The model is dimensionally reduced over the non-simply-connected space (Su(3)/U(1)xU(1))/Z{sub 2} giving in four dimensions the standard model. (orig.).

  19. Toward a Unified Theory of Reading

    Science.gov (United States)

    Sadoski, Mark; Paivio, Allan

    2007-01-01

    Despite nearly 40 years of scientific theorizing about reading, the field remains fragmented with little progress toward unification. In this article, we (a) emphasize the privileged position of unified theories in all science, (b) compare the growth of theory in cognitive science and reading, (c) identify the phenomenal domain of a unified…

  20. Unified classical path theories of pressure broadening.

    Science.gov (United States)

    Bottcher, C.

    1971-01-01

    Derivation of a unified classical path theory of pressure broadening, using only elementary concepts. It is shown that the theory of Smith, Cooper and Vidal (1969) is only correct at all frequencies to first order in the number density of perturbers.

  1. A Grand Unified Theory of Interdisciplinarity

    Science.gov (United States)

    Davis, Lennard J.

    2007-01-01

    Aside from the appeal to administrators as a tool to reduce costs by combining less robust departments with heftier relations, interdisciplinarity is a powerful idea because it implies that different branches of knowledge can benefit from talking to one another: a grand, unified theory of knowledge in which each discipline contributes building…

  2. A unified approach to Fierz identities

    Science.gov (United States)

    Babalic, E. M.; Coman, I. A.; Lazaroiu, C. I.

    2013-11-01

    We summarize a unified and computationally efficient treatment of Fierz identities for form-valued pinor bilinears in various dimensions and signatures, using concepts and techniques borrowed from a certain approach to spinors known as "geometric algebra". Our formulation displays the real, complex and quaternionic structures in a conceptually clear manner, which is moreover amenable to implementation in various symbolic computation systems.

  3. A unifying approach to CoDesign

    NARCIS (Netherlands)

    Achterop, S; Milligan, P; Coor, P

    1998-01-01

    Basic arguments are described to create a unified CoDesign environment. A unique feature is the use of a single language to describe systems. Different subsets describe hardware, both structure and behavior, as well a software. It vividly shows that software and hardware are much more alike than usu

  4. A Unifying View of Computational Electrochemistry

    Science.gov (United States)

    Bieniasz, L. K.

    2007-11-01

    The current state of development of Computational Electrochemistry is briefly discussed, and a unifying view of the field is proposed, with the aim of stimulating a communication between, and unity of, computationally oriented electrochemists involved in diverse kinds of computations. The most recent work of the author, pertaining to the field, is also reviewed.

  5. Discovery of the Grand Unified Theory

    Science.gov (United States)

    Nair, Radhakrishnan

    2010-11-01

    I have discovered the Grand Unified Theory which unites quantum with classical mechanics. This discovery is based on a geocentric universe, the myth of empty space, four states of matter in three dimensional space and space-time exponentiation, instead of space-time curvature.

  6. A unified stability property in spin glasses

    CERN Document Server

    Panchenko, Dmitry

    2011-01-01

    Gibbs' measures in the Sherrington-Kirkpatrick type models satisfy two asymptotic stability properties, the Aizenman-Contucci stochastic stability and the Ghirlanda-Guerra identities, which play a fundamental role in our current understanding of these models. In this paper we show that one can combine these two properties very naturally into one unified stability property.

  7. Computational Unified Set Theory and Application

    Institute of Scientific and Technical Information of China (English)

    Zhang Jiang; Li Xuewei; He Zhongxiong

    2006-01-01

    The computational unified set model (CUSM) as the latest progress of Unified Set theory is introduced in this paper. The model combines unified set theory, information granule, complex adaptive system and cognitive science to present a new approach to simulate the cognition of human beings that can be viewed as the evolutionary process through the automatic learning from data sets. The information granule, which is the unit of cognition in CUSM, can be synthesized and created by the basic operators. It also can form the granule network by linking with other granules. With the learning from database, the system can evolve under the pressure of selection. As the adaptive results, fuzzy sets, vague sets and rough sets, etc can emerge out spontaneously. The CUSM answers the question of the origin of the uncertainties in thinking process described by unified set theory, that is due to the emergent properties of a holistic system of multiple cognitive units. And also the CUSM creates a dynamic model that can adapt to the environment. As a result, the "closed world" limitation in machine learning may be broken. The paper also discusses the applications of CUSM in rules discovery, problem solving, clustering analysis and data mining etc. The main features of the model comparing with the classical approaches toward those problems are its adaptability, flexibility and robustness but not accuracy.

  8. UNIFIED THEORETICAL MOMENT EXPRESSIONS FOR ELUTION CHROMATOGRAPHY AND FRONTAL CHROMATOGRAPHY

    Institute of Scientific and Technical Information of China (English)

    YANGGengliang; TAOZuyi

    1992-01-01

    The unified theoretical moment expressions for elution chromatography and frontal chromatography when the sorption process is described by a linear model were derived. The moment expressions derived by previous authors can be obtained from these unified theoretical moment expressions. In this paper, a mathematical analysis has been carried out so as to set up a unified theoretical basis for elution and frontal chromatography.

  9. Towards a unified medical lexicon for French.

    Science.gov (United States)

    Zweigenbaum, Pierre; Baud, Robert; Burgun, Anita; Namer, Fiammetta; Jarrousse, Eric; Grabar, Natalia; Ruch, Patrick; Le Duff, Franck; Thirion, Benoît; Darmoni, Stéfan

    2003-01-01

    Medical Informatics has a constant need for basic Medical Language Processing tasks, e.g., for coding into controlled vocabularies, free text indexing and information retrieval. Most of these tasks involve term matching and rely on lexical resources: lists of words with attached information, including inflected forms and derived words, etc. Such resources are publicly available for the English language with the UMLS Specialist Lexicon, but not in other languages. For the French language, several teams have worked on the subject and built local lexical resources. The goal of the present work is to pool and unify these resources and to add extensively to them by exploiting medical terminologies and corpora, resulting in a unified medical lexicon for French (UMLF). This paper exposes the issues raised by such an objective, describes the methods on which the project relies and illustrates them with experimental results.

  10. UMLF: a unified medical lexicon for French.

    Science.gov (United States)

    Zweigenbaum, Pierre; Baud, Robert; Burgun, Anita; Namer, Fiammetta; Jarrousse, Eric; Grabar, Natalia; Ruch, Patrick; Le Duff, Franck; Forget, Jean-François; Douyère, Magaly; Darmoni, Stéfan

    2005-03-01

    Medical Informatics has a constant need for basic medical language processing tasks, e.g. for coding into controlled vocabularies, free text indexing and information retrieval. Most of these tasks involve term matching and rely on lexical resources: lists of words with attached information, including inflected forms and derived words, etc. Such resources are publicly available for the English language with the UMLS Specialist Lexicon, but not in other languages. For the French language, several teams have worked on the subject and built local lexical resources. The goal of the present work is to pool and unify these resources and to add extensively to them by exploiting medical terminologies and corpora, resulting in a unified medical lexicon for French (UMLF). This paper exposes the issues raised by such an objective, describes the methods on which the project relies and illustrates them with experimental results.

  11. Unified models of the cosmological dark sector

    Energy Technology Data Exchange (ETDEWEB)

    Zimdahl, W; Velten, H E S [Universidade Federal do EspIrito Santo, Departamento de Fisica, Av. Fernando Ferrari, 514, Campus de Goiabeiras, CEP 29075-910, Vitoria, EspIrito Santo (Brazil); Hipolito-Ricaldi, W S, E-mail: winfried.zimdahl@pq.cnpq.br, E-mail: hipolito@ceunes.ufes.br, E-mail: velten@cce.ufes.br [Universidade Federal do EspIrito Santo, Departamento de Ciencias Matematicas e Naturais, CEUNES Rodovia BR 101 Norte, km. 60, CEP 29932-540, Sao Mateus, Espirito Santo (Brazil)

    2011-09-22

    We model the cosmological substratum by a viscous fluid that is supposed to provide a unified description of the dark sector and pressureless baryonic matter. In the homogeneous and isotropic background the total energy density of this mixture behaves as a generalized Chaplygin gas. The perturbations of this energy density are intrinsically non-adiabatic and source relative entropy perturbations. The resulting baryonic matter power spectrum is shown to be compatible with the 2dFGRS and SDSS (DR7) data. A joint statistical analysis, using also Hubble-function and supernovae Ia data, shows that, different from other studies, there exists a maximum in the probability distribution for a negative present value q{sub 0} {approx} -0.53 of the deceleration parameter. Moreover, different from other approaches, the unified model presented here favors a matter content that is of the order of the baryonic matter abundance suggested by big-bang nucleosynthesis.

  12. Grand unified hidden-sector dark matter

    Science.gov (United States)

    Lonsdale, Stephen J.; Volkas, Raymond R.

    2014-10-01

    We explore G×G unified theories with the visible and the hidden or dark sectors paired under a Z2 symmetry. Developing a system of "asymmetric symmetry breaking" we motivate such models on the basis of their ability to generate dark baryons that are confined with a mass scale just above that of the proton, as motivated by asymmetric dark matter. This difference is achieved from the distinct but related confinement scales that develop in unified theories that have the two factors of G spontaneously breaking in an asymmetric manner. We show how Higgs potentials that admit different gauge group breaking chains in each sector can be constructed, and demonstrate the capacity for generating different fermion mass scales. Lastly we discuss supersymmetric extensions of such schemes.

  13. A survey of unified constitutive theories

    Science.gov (United States)

    Chan, K. S.; Lindholm, U. S.; Bodner, S. R.; Walker, K. P.

    1985-01-01

    The state of the art of time temperature dependent elastic viscoplastic constitutive theories which are based on the unified approach werre assessed. This class of constitutive theories is characterized by the use of kinetic equations and internal variables with appropriate evolutionary equations for treating all aspects of inelastic deformation including plasticity, creep, and stress relaxation. More than 10 such unified theories which are shown to satisfy the uniqueness and stability criteria imposed by Drucker's postulate and Ponter's inequalities are identified. The theories are compared for the types of flow law, kinetic equation, evolutionary equation of the internal variables, and treatment of temperature dependence. The similarities and differences of these theories are outlined in terms of mathematical formulations and illustrated by comparisons of theoretical calculations with experimental results which include monotonic stress-strain curves, cyclic hysteresis loops, creep and stress relaxation rates, and thermomechanical loops. Numerical methods used for integrating these stiff time temperature dependent constitutive equations are reviewed.

  14. Can the laws of physics be unified ?

    CERN Document Server

    Langacker, Paul

    2017-01-01

    The standard model of particle physics describes our current understanding of nature's fundamental particles and their interactions, yet gaps remain. For example, it does not include a quantum theory of gravity, nor does it explain the existence of dark matter. Once complete, however, the standard model could provide a unified description of the very building blocks of the universe. Researchers have been chasing this dream for decades, and many wonder whether such a dream can ever be made a reality. Can the Laws of Physics Be Unified? is a short introduction to this exciting frontier of physics. The book is accessibly written for students and researchers across the sciences, and for scientifically minded general readers. Paul Langacker begins with an overview of the key breakthroughs that have shaped the standard model, and then describes the fundamental particles, their interactions, and their role in cosmology. He goes on to explain field theory, internal symmetries, Yang-Mills theories, strong and electro...

  15. Multi-planed unified switching topologies

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Dong; Heidelberger, Philip; Sugawara, Yutaka

    2017-07-04

    An apparatus and method for extending the scalability and improving the partitionability of networks that contain all-to-all links for transporting packet traffic from a source endpoint to a destination endpoint with low per-endpoint (per-server) cost and a small number of hops. An all-to-all wiring in the baseline topology is decomposed into smaller all-to-all components in which each smaller all-to-all connection is replaced with star topology by using global switches. Stacking multiple copies of the star topology baseline network creates a multi-planed switching topology for transporting packet traffic. Point-to-point unified stacking method using global switch wiring methods connects multiple planes of a baseline topology by using the global switches to create a large network size with a low number of hops, i.e., low network latency. Grouped unified stacking method increases the scalability (network size) of a stacked topology.

  16. Unified viscoplastic constitutive equations and their applications

    Science.gov (United States)

    Lindholm, U. S.

    1987-01-01

    Unified constitutive equations for time- and temperature-dependent metallic plastic deformation have been applied in FEM simulations of forming processes; increasingly powerful computational tools and physical models are being used to numerically model complex engineering problems. Once confidence has been gained through adequate verification, these numerical models will increasingly replace experimental models. Attention is presently given to the contributions made by physical metallurgy, continuum mechanics, and computational mechanics.

  17. Implementation of a Unified DSP Coprocessor

    Directory of Open Access Journals (Sweden)

    2012-01-01

    Full Text Available Utilizing the DFT, the DHT, the DCT or the DST is an obvious choice in signal processing domain. This paper describes the implementation of a unified coprocessor of transform length '8' for the synchronous design in XC3S1400AN-4FG484 FPGA device of Xilinx Company. The operating frequency of 20 MHz is achieved. The paper presents the trade-offs involved in designing the architecture, the design for performance issues and the possibilities for future development.

  18. Unifying Theories in Isabelle/HOL

    Science.gov (United States)

    Feliachi, Abderrahmane; Gaudel, Marie-Claude; Wolff, Burkhart

    In this paper, we present various extensions of Isabelle/HOL by theories that are essential for several formal methods. First, we explain how we have developed an Isabelle/HOL theory for a part of the Unifying Theories of Programming (UTP). It contains the theories of alphabetized relations and designs. Then we explain how we have encoded first the theory of reactive processes and then the UTP theory for CSP. Our work takes advantage of the rich existing logical core of HOL.

  19. Towards a unified theory of reciprocity.

    Science.gov (United States)

    Rosas, Alejandro

    2012-02-01

    In a unified theory of human reciprocity, the strong and weak forms are similar because neither is biologically altruistic and both require normative motivation to support cooperation. However, strong reciprocity is necessary to support cooperation in public goods games. It involves inflicting costs on defectors; and though the costs for punishers are recouped, recouping costs requires complex institutions that would not have emerged if weak reciprocity had been enough.

  20. Unifying Ancient and Modern Geometries Through Octonions

    Science.gov (United States)

    Catto, Sultan; Gürcan, Yasemin; Khalfan, Amish; Kurt, Levent

    2016-01-01

    We show the first unified description of some of the oldest known geometries such as the Pappus’ theorem with more modern ones like Desargues' theorem, Monge's theorem and Ceva's theorem, through octonions, the highest normed division algebra in eight dimensions. We also show important applications in hadronic physics, giving a full description of the algebra of color applicable to quark physics, and comment on further applications.

  1. Unified sensor management in unknown dynamic clutter

    Science.gov (United States)

    Mahler, Ronald; El-Fallah, Adel

    2010-04-01

    In recent years the first author has developed a unified, computationally tractable approach to multisensor-multitarget sensor management. This approach consists of closed-loop recursion of a PHD or CPHD filter with maximization of a "natural" sensor management objective function called PENT (posterior expected number of targets). In this paper we extend this approach so that it can be used in unknown, dynamic clutter backgrounds.

  2. Unifying physics of accelerators, lasers and plasma

    CERN Document Server

    Seryi, Andrei

    2015-01-01

    Unifying Physics of Accelerators, Lasers and Plasma introduces the physics of accelerators, lasers and plasma in tandem with the industrial methodology of inventiveness, a technique that teaches that similar problems and solutions appear again and again in seemingly dissimilar disciplines. This unique approach builds bridges and enhances connections between the three aforementioned areas of physics that are essential for developing the next generation of accelerators.

  3. A unified architecture of transcriptional regulatory elements

    DEFF Research Database (Denmark)

    Andersson, Robin; Sandelin, Albin Gustav; Danko, Charles G.

    2015-01-01

    Gene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications. However...... and enhancers are considered a single class of functional element, with a unified architecture for transcription initiation. The context of interacting regulatory elements and the surrounding sequences determine local transcriptional output as well as the enhancer and promoter activities of individual elements....

  4. Unified QCD picture of hard diffraction

    CERN Document Server

    Navelet, H

    2001-01-01

    Using a combination of S-Matrix and perturbative QCD properties in the small x_{Bjorken} regime, we propose a formulation of hard diffraction unifying the partonic (Ingelman-Schlein) Pomeron, Soft Colour Interaction and QCD dipole descriptions. In particular, we show that all three approaches give an unique and mutually compatible formula for the proton diffractive structure functions incorporating perturbative and non perturbative QCD features.

  5. Unified Models of Inflation and Quintessence

    CERN Document Server

    González, A; Quirós, I; Gonzalez, Andro; Matos, Tonatiuh; Quiros, Israel

    2004-01-01

    We apply an extended version of the method developed in reference Int.J.Mod.Phys.D5(1996)71, to derive exact cosmological (flat) Friedmann-Robertson-Walker solutions in RS2 brane models with a perfect fluid of ordinary matter plus a scalar field fluid trapped on the brane. We found new exact solutions, that can serve to unify inflation and quintessence in a common theoretical framework.

  6. Unified treatment of lifting atmospheric entry

    Science.gov (United States)

    Nachtsheim, P. R.; Lehman, L. L.

    1980-01-01

    This paper presents a unified treatment of the effect of lift on peak acceleration during atmospheric entry. Earlier studies were restricted to different regimes because of approximations invoked to solve the same transcendental equation. This paper shows the connection between the earlier studies by employing a general expression for the peak acceleration and obtains solutions to the transcendental equation without invoking the earlier approximations. Results are presented and compared with earlier studies where appropriate.

  7. Image segmentation with a unified graphical model.

    Science.gov (United States)

    Zhang, Lei; Ji, Qiang

    2010-08-01

    We propose a unified graphical model that can represent both the causal and noncausal relationships among random variables and apply it to the image segmentation problem. Specifically, we first propose to employ Conditional Random Field (CRF) to model the spatial relationships among image superpixel regions and their measurements. We then introduce a multilayer Bayesian Network (BN) to model the causal dependencies that naturally exist among different image entities, including image regions, edges, and vertices. The CRF model and the BN model are then systematically and seamlessly combined through the theories of Factor Graph to form a unified probabilistic graphical model that captures the complex relationships among different image entities. Using the unified graphical model, image segmentation can be performed through a principled probabilistic inference. Experimental results on the Weizmann horse data set, on the VOC2006 cow data set, and on the MSRC2 multiclass data set demonstrate that our approach achieves favorable results compared to state-of-the-art approaches as well as those that use either the BN model or CRF model alone.

  8. Unified strength theory and its applications

    CERN Document Server

    Yu, Mao-Hong

    2004-01-01

    This is a completely new theory dealing with the yield and failure of materials under multi-axial stresses. It provides a system of yield and failure criteria adopted for most materials, from metallic materials to rocks, concretes, soils, polymers etc. The Unified Strength Theory has been applied successfully to analyse the elastic limit, plastic limit capacities, the dynamic response behavior for some structures under static and moderate impulsive load, and may be implemented in some elasto-plastic finite element computer codes. The Unified Strength Theory is described in detail and by using this theory a series of results can be obtained. The Unified Strength Theory can improve the conservative Mohr-Coulomb Theory, and since intermediate principal stress is not taken into account in the Mohr-Coulomb theory and most experimental data is not pertainable to the Mohr-Coulomb Theory, a considerable economic benefit may be obtained. The book can also increase the effect of most commercial finite element computer ...

  9. Unifying theory for terrestrial research infrastructures

    Science.gov (United States)

    Mirtl, Michael

    2016-04-01

    The presentation will elaborate on basic steps needed for building a common theoretical base between Research Infrastructures focusing on terrestrial ecosystems. This theoretical base is needed for developing a better cooperation and integrating in the near future. An overview of different theories will be given and ways to a unifying approach explored. In the second step more practical implications of a theory-guided integration will be developed alongside the following guiding questions: • How do the existing and planned European environmental RIs map on a possible unifying theory on terrestrial ecosystems (covered structures and functions, scale; overlaps and gaps) • Can a unifying theory improve the consistent definition of RÍs scientific scope and focal science questions? • How could a division of tasks between RIs be organized in order to minimize parallel efforts? • Where concretely do existing and planned European environmental RIs need to interact to respond to overarching questions (top down component)? • What practical fora and mechanisms (across RIs) would be needed to bridge the gap between PI driven (bottom up) efforts and the centralistic RI design and operations?

  10. Unified Gauge Field Theory and Topological Transitions

    CERN Document Server

    Patwardhan, A

    2004-01-01

    The search for a Unified description of all interactions has created many developments of mathematics and physics. The role of geometric effects in the Quantum Theory of particles and fields and spacetime has been an active topic of research. This paper attempts to obtain the conditions for a Unified Gauge Field Theory, including gravity. In the Yang Mills type of theories with compactifications from a 10 or 11 dimensional space to a spacetime of 4 dimensions, the Kaluza Klein and the Holonomy approach has been used. In the compactifications of Calabi Yau spaces and sub manifolds, the Euler number Topological Index is used to label the allowed states and the transitions. With a SU(2) or SL(2,C) connection for gravity and the U(1)*SU(2)*SU(3) or SU(5) gauge connection for the other interactions, a Unified gauge field theory is expressed in the 10 or 11 dimension space. Partition functions for the sum over all possible configurations of sub spaces labeled by the Euler number index and the Action for gauge and m...

  11. Unified solutions for stresses and displacements around circular tunnels using the Unified Strength Theory

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The unified solutions are presented for stresses and displacements around a circular tunnel subjected to a hydrostatic stress field.The rock mass is assumed to be elastic-brittle-plastic and governed by the Unified Strength Theory.The displacements are obtained accounting for three different definitions for elastic strains and different Young’s modulus in the plastic zone.The unified solutions obtained in this paper are especially versatile in reflecting the intermediate principal stress effect to different extents for different materials.The conventional solutions,based on the Mohr-Coulomb failure criterion and the Generalized Twin Shear Stress yield criterion,are special cases of the present unified solutions.The new unified solutions can compare with those computed by the latest generalized Hoek-Brown failure criterion.The results obtained demonstrate the importance of the intermediate principal stress influence for the stresses and displacements analysis.The effects of different definitions for elastic strains and different Young’s modulus in the plastic zone on the displacements are significant.

  12. Proposal for a unified selection to medical residency programs.

    Science.gov (United States)

    Toffoli, Sônia Ferreira Lopes; Ferreira Filho, Olavo Franco; Andrade, Dalton Francisco de

    2013-01-01

    This paper proposes the unification of entrance exams to medical residency programs (MRP) in Brazil. Problems related to MRP and its interface with public health problems in Brazil are highlighted and how this proposal are able to help solving these problems. The proposal is to create a database to be applied in MRP unified exams. Some advantages of using the Item Response Theory (IRT) in this database are highlighted. The MRP entrance exams are developed and applied decentralized where each school is responsible for its examination. These exams quality are questionable. Reviews about items quality, validity and reliability of appliances are not common disclosed. Evaluation is important in every education system bringing on required changes and control of teaching and learning. The proposal of MRP entrance exams unification, besides offering high quality exams to institutions participants, could be as an extra source to rate medical school and cause improvements, provide studies with a database and allow a regional mobility. Copyright © 2013 Elsevier Editora Ltda. All rights reserved.

  13. Unifying the Booch and OMT OO Development Methods Introduction to the Unified Method

    CERN Document Server

    Rumbaugh, James

    1995-01-01

    The Booch and OMT methods represent the two most mature and widely used approaches to object-oriented analysis and design.Since their introduction 6 years ago both have evolved and from other methods. This talk describes the unification of the Booch and OMT methods by Grady Booch and Jim Rumbaugh leading to the recent public release of over 100 pages of documentation describing the Unified Method models and notation.THE aUTHORS ARE NOW AWAITING PUBLIC FEEDBACK BEFORE COMPLETING A FINAL VERSION OF THE METHOD NEXT YEAR. Contents: The Drive to Unification - why and how it happened The Unified Metamodel - the formal description of the models The Unified Notation - the new notation based on Booch and OMT Future Work - open problems that we are working on Roadmap - how users can get involved

  14. New Mexico, 2010 Census Unified School District Shapefile

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — The TIGER/Line Files are shapefiles and related database files (.dbf) that are an extract of selected geographic and cartographic information from the U.S. Census...

  15. Madera Unified School District, 2004-2009. District Case Study

    Science.gov (United States)

    Pivot Learning Partners, 2012

    2012-01-01

    Situated in the heart of the fertile San Joaquin Valley twenty miles north of Fresno, the city of Madera has a population of 56,710 people. Agriculture is the driving force behind the local economy; the area produces more than 100 crops including raisin grapes, almonds, figs, pistachios, alfalfa, corn, milk, cattle and poultry. The total value of…

  16. Madera Unified School District, 2004-2009. District Case Study

    Science.gov (United States)

    Pivot Learning Partners, 2012

    2012-01-01

    Situated in the heart of the fertile San Joaquin Valley twenty miles north of Fresno, the city of Madera has a population of 56,710 people. Agriculture is the driving force behind the local economy; the area produces more than 100 crops including raisin grapes, almonds, figs, pistachios, alfalfa, corn, milk, cattle and poultry. The total value of…

  17. Inflationary Reheating in Grand Unified Theories

    CERN Document Server

    Bassett, B A; Bassett, Bruce A.; Tamburini, Fabrizio

    1998-01-01

    Grand unified theories may display multiply interacting fields with strong coupling dynamics. This poses two new problems: (1) What is the nature of chaotic reheating after inflation, and (2) How is reheating sensitive to the mass spectrum of these theories ? We answer these questions in two interesting limiting cases and demonstrate an increased efficiency of reheating which strongly enhances non-thermal topological defect formation, including monopoles and domain walls. Nevertheless, the large fluctuations may resolve this monopole problem via a modified Dvali-Liu-Vachaspati mechanism in which non-thermal destabilsation of discrete symmetries occurs at reheating.

  18. Leading gravitational corrections and a unified universe

    DEFF Research Database (Denmark)

    Codello, Alessandro; Jain, Rajeev Kumar

    2016-01-01

    Leading order gravitational corrections to the Einstein-Hilbert action can lead to a consistent picture of the universe by unifying the epochs of inflation and dark energy in a single framework. While the leading local correction induces an inflationary phase in the early universe, the leading...... nonlocal term leads to an accelerated expansion of the universe at the present epoch. We argue that both the leading UV and IR terms can be obtained within the framework of a covariant effective field theory of gravity. The perturbative gravitational corrections therefore provide a fundamental basis...

  19. Principles for a Unified Picture of Fermions

    CERN Document Server

    Nishimura, Kimihide

    2012-01-01

    The principles and conceptual foundations required for a unified picture of fermions are clarified, which in turn suggest that the standard theory may be reducible in a far simpler form. The resultant three generation model describes quarks and leptons as quasi excitations of a single chiral doublet, while electromagnetic and strong interactions as secondary interactions mediated by Nambu-Goldstone bosons originated from spontaneous violations of global SU(2) and Lorentz symmetries. The model also provides an alternative scenario for baryon and lepton asymmetries of the Universe.

  20. TOWARDS A UNIFIED VIEW OF METAHEURISTICS

    Directory of Open Access Journals (Sweden)

    El-Ghazali Talbi

    2013-02-01

    Full Text Available This talk provides a complete background on metaheuristics and presents in a unified view the main design questions for all families of metaheuristics and clearly illustrates how to implement the algorithms under a software framework to reuse both the design and code. The key search components of metaheuristics are considered as a toolbox for: - Designing efficient metaheuristics (e.g. local search, tabu search, simulated annealing, evolutionary algorithms, particle swarm optimization, scatter search, ant colonies, bee colonies, artificial immune systems for optimization problems. - Designing efficient metaheuristics for multi-objective optimization problems. - Designing hybrid, parallel and distributed metaheuristics. - Implementing metaheuristics on sequential and parallel machines.

  1. Unified Framework for Finite Element Assembly

    CERN Document Server

    Alnæs, Martin Sandve; Mardal, Kent-Andre; Skavhaug, Ola; Langtangen, Hans Petter; 10.1504/IJCSE.2009.029160

    2012-01-01

    At the heart of any finite element simulation is the assembly of matrices and vectors from discrete variational forms. We propose a general interface between problem-specific and general-purpose components of finite element programs. This interface is called Unified Form-assembly Code (UFC). A wide range of finite element problems is covered, including mixed finite elements and discontinuous Galerkin methods. We discuss how the UFC interface enables implementations of variational form evaluation to be independent of mesh and linear algebra components. UFC does not depend on any external libraries, and is released into the public domain.

  2. Constraints on dissipative unified dark matter

    CERN Document Server

    Velten, Hermano

    2011-01-01

    Modern cosmology suggests that the Universe contains two dark components -- dark matter and dark energy -- both unkown in laboratory physics and both lacking direct evidence. Alternatively, a unified dark sector, described by a single fluid, has been proposed. Dissipation is a common phenomenon in nature and it thus seems natural to consider models dominated by a viscous dark fluid. We focus on the study of bulk viscosity, as isotropy and homogeneity at large scales implies the suppression of shear viscosity, heat flow and diffusion. The generic ansatz $\\xi \\propto \\rho^{\

  3. Evolution of OO Methods: the unified case

    Directory of Open Access Journals (Sweden)

    Matti Rossi

    1997-05-01

    Full Text Available This paper takes an evaluative look into OO methods and especially the evolution of the new snified method from its ancestors, OMT and OODA. The paper ries to classify the components of the earlier ethods and identify the parts that have been taken into the Unified ethod. The research applies the method metrics approach. For the sake of compactness we limit ourselves to the class diagram technique of all methods. We make observations about the number of concepts in each variation and show how the metrics can be used to analyse the changes in the techniques.

  4. Mainstreaming the Sustainably Designed School.

    Science.gov (United States)

    Weintraub, Deborah; Pierce, Tony

    This paper documents a school building energy efficiency and sustainability project involving the Newport Mesa Unified School District, Southern California Edison's Design and Engineering Services (D&ES), and the architectural firm Perkins and Will. The paper first examines the project design objectives and then discusses each of the project…

  5. Making Schools Future-Proof

    Science.gov (United States)

    Dessoff, Alan

    2011-01-01

    Under pressure to keep spending down but also keep pace with rapid technology changes, many districts are future-proofing their schools--trying to get the most out of tech spending by providing solutions they can use now and in the future without major, expensive infrastructure overhauls. In the Folsom Cordova (California) Unified School District,…

  6. Mainstreaming the Sustainably Designed School.

    Science.gov (United States)

    Weintraub, Deborah; Pierce, Tony

    This paper documents a school building energy efficiency and sustainability project involving the Newport Mesa Unified School District, Southern California Edison's Design and Engineering Services (D&ES), and the architectural firm Perkins and Will. The paper first examines the project design objectives and then discusses each of the project…

  7. Control of a Unified Chaotic System via Single Variable Feedback

    Science.gov (United States)

    Guo, Rong-Wei; Vincent E., U.

    2009-09-01

    Based on the LaSalle invariance principle, we propose a simple adaptive-feedback for controlling the unified chaotic system. We show explicitly with numerical proofs that our method can easily achieve the control of chaos in the unified chaotic system using only a single variable feedback. The present controller, to our knowledge, is the simplest control scheme for controlling a unified chaotic system.

  8. Circuit realization of the fractional-order unified chaotic system

    Institute of Scientific and Technical Information of China (English)

    Chen Xiang-Rong; Liu Chong-Xin; Wang Fa-Qiang

    2008-01-01

    This paper studies the chaotic behaviours of the fractional-order unified chaotic system.Based on the approximation method in frequency domain,it proposes an electronic circuit model of tree shape to realize the fractional-order operator.According to the tree shape model,an electronic circuit is designed to realize the 2.7-order unified chaotic system.Numerical simulations and circuit experiments have verified the existence of chaos in the fraction-order unified system.

  9. Cascade adaptive control of uncertain unified chaotic systems

    Institute of Scientific and Technical Information of China (English)

    Wei Wei; Li Dong-Hai; Wang Jing

    2011-01-01

    The chaos control of uncertain unified chaotic systems is considered. Cascade adaptive control approach with only one control input is presented to stabilize states of the uncertain unified chaotic system at the zero equilibrium point.Since an adaptive controller based on dynamic compensation mechanism is employed, the exact model of the unified chaotic system is not necessarily required.By choosing appropriate controller parameters, chaotic phenomenon can be suppressed and the response speed is tunable. Sufficient condition for the asymptotic stability of the approach is derived. Numerical simulation results confirm that the cascade adaptive control approach with only one control signal is valid in chaos control of uncertain unified chaotic systems.

  10. A Unified Evolution of the Universe

    CERN Document Server

    Codello, Alessandro

    2016-01-01

    We present a unified evolution of the universe from very early times until the present epoch by including both the leading local correction $R^2$ and the leading non-local term $R\\frac{1}{\\square^2}R$ to the classical gravitational action. We find that the inflationary phase driven by $R^2$ term gracefully exits in a transitory regime characterized by coherent oscillations of the Hubble parameter. The universe then naturally enters into a radiation dominated epoch followed by a matter dominated era. At sufficiently late times after radiation-matter equality, the non-local term starts to dominate inducing an accelerated expansion of the universe at the present epoch. We further exhibit the fact that both the leading local and non-local terms can be obtained within the covariant effective field theory of gravity. Our scenario thus provides a unified picture of inflation and dark energy in a single framework by means of a purely gravitational action without the usual need of a scalar field.

  11. A Unified Theoretical Framework for Cognitive Sequencing.

    Science.gov (United States)

    Savalia, Tejas; Shukla, Anuj; Bapi, Raju S

    2016-01-01

    The capacity to sequence information is central to human performance. Sequencing ability forms the foundation stone for higher order cognition related to language and goal-directed planning. Information related to the order of items, their timing, chunking and hierarchical organization are important aspects in sequencing. Past research on sequencing has emphasized two distinct and independent dichotomies: implicit vs. explicit and goal-directed vs. habits. We propose a theoretical framework unifying these two streams. Our proposal relies on brain's ability to implicitly extract statistical regularities from the stream of stimuli and with attentional engagement organizing sequences explicitly and hierarchically. Similarly, sequences that need to be assembled purposively to accomplish a goal require engagement of attentional processes. With repetition, these goal-directed plans become habits with concomitant disengagement of attention. Thus, attention and awareness play a crucial role in the implicit-to-explicit transition as well as in how goal-directed plans become automatic habits. Cortico-subcortical loops basal ganglia-frontal cortex and hippocampus-frontal cortex loops mediate the transition process. We show how the computational principles of model-free and model-based learning paradigms, along with a pivotal role for attention and awareness, offer a unifying framework for these two dichotomies. Based on this framework, we make testable predictions related to the potential influence of response-to-stimulus interval (RSI) on developing awareness in implicit learning tasks.

  12. Simplification of the unified gas kinetic scheme

    Science.gov (United States)

    Chen, Songze; Guo, Zhaoli; Xu, Kun

    2016-08-01

    The unified gas kinetic scheme (UGKS) is an asymptotic preserving (AP) scheme for kinetic equations. It is superior for transition flow simulation and has been validated in the past years. However, compared to the well-known discrete ordinate method (DOM), which is a classical numerical method solving the kinetic equations, the UGKS needs more computational resources. In this study, we propose a simplification of the unified gas kinetic scheme. It allows almost identical numerical cost as the DOM, but predicts numerical results as accurate as the UGKS. In the simplified scheme, the numerical flux for the velocity distribution function and the numerical flux for the macroscopic conservative quantities are evaluated separately. The equilibrium part of the UGKS flux is calculated by analytical solution instead of the numerical quadrature in velocity space. The simplification is equivalent to a flux hybridization of the gas kinetic scheme for the Navier-Stokes (NS) equations and the conventional discrete ordinate method. Several simplification strategies are tested, through which we can identify the key ingredient of the Navier-Stokes asymptotic preserving property. Numerical tests show that, as long as the collision effect is built into the macroscopic numerical flux, the numerical scheme is Navier-Stokes asymptotic preserving, regardless the accuracy of the microscopic numerical flux for the velocity distribution function.

  13. A Unified Theoretical Framework for Cognitive Sequencing

    Directory of Open Access Journals (Sweden)

    Tejas Savalia

    2016-11-01

    Full Text Available The capacity to sequence information is central to human performance. Sequencing ability forms the foundation stone for higher order cognition related to language and goal-directed planning. Information related to the order of items, their timing, chunking and hierarchical organization are important aspects in sequencing. Past research on sequencing has emphasized two distinct and independent dichotomies: implicit versus explicit and goal-directed versus habits. We propose a theoretical framework unifying these two streams. Our proposal relies on brain's ability to implicitly extract statistical regularities from the stream of stimuli and with attentional engagement organizing sequences explicitly and hierarchically. Similarly, sequences that need to be assembled purposively to accomplish a goal require engagement of attentional processes. With repetition, these goal-directed plans become habits with concomitant disengagement of attention. Thus attention and awareness play a crucial role in the implicit-to-explicit transition as well as in how goal-directed plans become automatic habits. Cortico-subcortical loops ─ basal ganglia-frontal cortex and hippocampus-frontal cortex loops ─ mediate the transition process. We show how the computational principles of model-free and model-based learning paradigms, along with a pivotal role for attention and awareness, offer a unifying framework for these two dichotomies. Based on this framework, we make testable predictions related to the potential influence of response-to-stimulus interval (RSI on developing awareness in implicit learning tasks.

  14. Towards a Unified Global ICT Infrastructure

    DEFF Research Database (Denmark)

    Madsen, Ole Brun

    2006-01-01

    A successful evolution towards a unified global WAN platform allowing for the coexistence and interoperability of all kind of services requires careful planning of the next generation global cooperative wired and wireless information infrastructure. The absence of commonly agreed upon and adopted...... to be solved can be found in the interrelation between communication, connectivity and convergence. This paper will focus on steps to be taken in planning the physical infrastructure as a prerequisite for a successful evolution.......A successful evolution towards a unified global WAN platform allowing for the coexistence and interoperability of all kind of services requires careful planning of the next generation global cooperative wired and wireless information infrastructure. The absence of commonly agreed upon and adopted...... design principles, allowing for smooth and cost efficient scalability without loss of control over the structurally based properties may prevent or seriously delay this evolution and as consequence be a barrier for introduction of new foreseen types of demanding services. Some of the key problems...

  15. DataSpread: Unifying Databases and Spreadsheets.

    Science.gov (United States)

    Bendre, Mangesh; Sun, Bofan; Zhang, Ding; Zhou, Xinyan; Chang, Kevin ChenChuan; Parameswaran, Aditya

    2015-08-01

    Spreadsheet software is often the tool of choice for ad-hoc tabular data management, processing, and visualization, especially on tiny data sets. On the other hand, relational database systems offer significant power, expressivity, and efficiency over spreadsheet software for data management, while lacking in the ease of use and ad-hoc analysis capabilities. We demonstrate DataSpread, a data exploration tool that holistically unifies databases and spreadsheets. It continues to offer a Microsoft Excel-based spreadsheet front-end, while in parallel managing all the data in a back-end database, specifically, PostgreSQL. DataSpread retains all the advantages of spreadsheets, including ease of use, ad-hoc analysis and visualization capabilities, and a schema-free nature, while also adding the advantages of traditional relational databases, such as scalability and the ability to use arbitrary SQL to import, filter, or join external or internal tables and have the results appear in the spreadsheet. DataSpread needs to reason about and reconcile differences in the notions of schema, addressing of cells and tuples, and the current "pane" (which exists in spreadsheets but not in traditional databases), and support data modifications at both the front-end and the back-end. Our demonstration will center on our first and early prototype of the DataSpread, and will give the attendees a sense for the enormous data exploration capabilities offered by unifying spreadsheets and databases.

  16. A unified view of "how allostery works".

    Directory of Open Access Journals (Sweden)

    Chung-Jung Tsai

    2014-02-01

    Full Text Available The question of how allostery works was posed almost 50 years ago. Since then it has been the focus of much effort. This is for two reasons: first, the intellectual curiosity of basic science and the desire to understand fundamental phenomena, and second, its vast practical importance. Allostery is at play in all processes in the living cell, and increasingly in drug discovery. Many models have been successfully formulated, and are able to describe allostery even in the absence of a detailed structural mechanism. However, conceptual schemes designed to qualitatively explain allosteric mechanisms usually lack a quantitative mathematical model, and are unable to link its thermodynamic and structural foundations. This hampers insight into oncogenic mutations in cancer progression and biased agonists' actions. Here, we describe how allostery works from three different standpoints: thermodynamics, free energy landscape of population shift, and structure; all with exactly the same allosteric descriptors. This results in a unified view which not only clarifies the elusive allosteric mechanism but also provides structural grasp of agonist-mediated signaling pathways, and guides allosteric drug discovery. Of note, the unified view reasons that allosteric coupling (or communication does not determine the allosteric efficacy; however, a communication channel is what makes potential binding sites allosteric.

  17. Inelastic mechanics: A unifying principle in biomechanics.

    Science.gov (United States)

    Gralka, Matti; Kroy, Klaus

    2015-11-01

    Many soft materials are classified as viscoelastic. They behave mechanically neither quite fluid-like nor quite solid-like - rather a bit of both. Biomaterials are often said to fall into this class. Here, we argue that this misses a crucial aspect, and that biomechanics is essentially damage mechanics, at heart. When deforming an animal cell or tissue, one can hardly avoid inducing the unfolding of protein domains, the unbinding of cytoskeletal crosslinkers, the breaking of weak sacrificial bonds, and the disruption of transient adhesions. We classify these activated structural changes as inelastic. They are often to a large degree reversible and are therefore not plastic in the proper sense, but they dissipate substantial amounts of elastic energy by structural damping. We review recent experiments involving biological materials on all scales, from single biopolymers over cells to model tissues, to illustrate the unifying power of this paradigm. A deliberately minimalistic yet phenomenologically very rich mathematical modeling framework for inelastic biomechanics is proposed. It transcends the conventional viscoelastic paradigm and suggests itself as a promising candidate for a unified description and interpretation of a wide range of experimental data. This article is part of a Special Issue entitled: Mechanobiology.

  18. A Unified ASrchitecture Model of Web Applications

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    With the increasing popularity,scale and complexity of web applications,design and development of web applications are becoming more and more difficult,However,the current state of their design and development is characterized by anarchy and ad hoc methodologies,One of the causes of this chaotic situation is that different researchers and designers have different understanding of web applications.In this paper,based on an explicit understanding of web applications,we present a unified architecture model of wed applications,the four-view model,which addresses the analysis and design issues of web applications from four perspectives,namely,logical view,data view,navigation view and presentation view,each addrssing a specific set of concerns of web applications,the purpose of the model is to provide a clear picture of web applications to alleviate the chaotic situation and facilitate its analysis,design and implementation.

  19. A Model of Unified Gauge Interactions

    CERN Document Server

    Lindesay, James

    2016-01-01

    Linear spinor fields are a generalization of the Dirac field that have direct correspondence with the known physics of fermions, inherent causality properties in their most fundamental constructions, and positive mass eigenvalues for all particle types. The algebra of the generators for infinitesimal transformations of these fields directly constructs the Minkowski metric \\emph{within} the internal group space as a consequence of non-vanishing commutation relations between generators that carry space-time indexes. In addition, the generators have a fundamental matrix representation that includes Lorentz transformations within a group that unifies internal gauge symmetries generated by a set of hermitian generators for SU(3)$\\times$SU(2)$\\times$U(1), and nothing else. The construction of linearly independent internal SU(3) and SU(2) symmetry groups necessarily involves the mixing of three generations of the mass eigenstates labeling the (massive) representations of the linear spinor fields. The group algebra a...

  20. Towards unifying inheritance and automatic program specialization

    DEFF Research Database (Denmark)

    Schultz, Ulrik Pagh

    2002-01-01

    Inheritance allows a class to be specialized and its attributes refined, but implementation specialization can only take place by overriding with manually implemented methods. Automatic program specialization can generate a specialized, effcient implementation. However, specialization of programs...... and specialization of classes (inheritance) are considered different abstractions. We present a new programming language, Lapis, that unifies inheritance and program specialization at the conceptual, syntactic, and semantic levels. This paper presents the initial development of Lapis, which uses inheritance...... with covariant specialization to control the automatic application of program specialization to class members. Lapis integrates object-oriented concepts, block structure, and techniques from automatic program specialization to provide both a language where object-oriented designs can be e#ciently implemented...

  1. A unified theory of coronal heating

    Science.gov (United States)

    Ionson, J. A.

    1985-01-01

    Solar coronal heating mechanisms are analyzed within the framework of a unified theory of heating processes. The theory is based on the standing wave equation of Ionson (1982) for the global current driven by emfs from the convection Beta less than 1. The equation has the same form as a driven LRC equation in which the equivalent inductance is scaled with the coronal loop length. The theory is used to classify various heating mechanisms inside the coronal loops. It is shown that the total global current can be obtained from an integration of the local currents, the degree of coherency between local currents being the dominant factor governing the global current amplitude. Active region loops appear to be heated by electrodynamic coupling to p-mode oscillations in the convection Beta less than 1.

  2. A unified innovation approach to emerging markets

    DEFF Research Database (Denmark)

    Agarwal, Nivedita; Brem, Alexander; Grottke, Michael

    2014-01-01

    Previous research shows a plethora of overlapping and interrelated innovation approaches to understand the bottom of the pyramid customer needs and markets specifications. This research attempts to (1) identify the key factors that make a product relevant to be considered as an innovation...... for emerging markets (2) and establish relative importance of key factors for product managers while conceptualizing a new product for emerging markets. In the first part, the study assembles the list of characteristics from the selected innovation theories revolving around emerging markets. Subsequently...... the identified characteristics are clustered into eight key factors using semantic similarities scores and Ward’s clustering method. An analytical hierarchy process method is employed to obtain the priorities of these eight key factors. The study concludes with a Unified Innovation Framework which presents...

  3. A UNIFIED MODEL FOR SOLAR FLARES

    Institute of Scientific and Technical Information of China (English)

    ChenPengfei; FangCheng; DingMingde; TangYuhua

    1999-01-01

    We performed 2.5 - dimensional numerical simulation for two cases, one with the the reconnection point at a high altitude, the other with the reconnection point at a low altitude, in the high-altitude case, the bright loop appears to rise for a long time, with its two footpoints separating and the field lines below the bright loop shrinking,which are all typical features of two - ribbon flares. In the low- altitude case, the bright loops cease rising only a short time after the impulsive phase of the reconnection and then become rather stable, which shows a large similarity to the compact flares. The results imply that the two types of solar flares, i. e., the two - ribbon flares and the compact ones, might be unified into the same magnetic reconnection model, where the height of the reconnection point leads to the bifurcation.

  4. Hilltop supernatural inflation and SUSY unified models

    Energy Technology Data Exchange (ETDEWEB)

    Kohri, Kazunori [Cosmophysics Group, Theory Center, IPNS KEK, and The Graduate University for Advanced Studies (Sokendai), 1-1 Oho, Tsukuba, 305-0801 (Japan); Lim, C.S. [Department of Mathematics, Tokyo Woman' s Christian University, Tokyo, 167-8585 (Japan); Lin, Chia-Min [Department of Physics, Chuo University, Bunkyo-ku, Tokyo, 112 (Japan); Mimura, Yukihiro, E-mail: kohri@post.kek.jp, E-mail: lim@lab.twcu.ac.jp, E-mail: lin@chuo-u.ac.jp, E-mail: mimura@hep1.phys.ntu.edu.tw [Department of Physics, National Taiwan University, Taipei, 10617 Taiwan (China)

    2014-01-01

    In this paper, we consider high scale (100TeV) supersymmetry (SUSY) breaking and realize the idea of hilltop supernatural inflation in concrete particle physics models based on flipped-SU(5)and Pati-Salam models in the framework of supersymmetric grand unified theories (SUSY GUTs). The inflaton can be a flat direction including right-handed sneutrino and the waterfall field is a GUT Higgs. The spectral index is n{sub s} = 0.96 which fits very well with recent data by PLANCK satellite. There is no both thermal and non-thermal gravitino problems. Non-thermal leptogenesis can be resulted from the decay of right-handed sneutrino which plays (part of) the role of inflaton.

  5. Hilltop supernatural inflation and SUSY unified models

    Science.gov (United States)

    Kohri, Kazunori; Lim, C. S.; Lin, Chia-Min; Mimura, Yukihiro

    2014-01-01

    In this paper, we consider high scale (100TeV) supersymmetry (SUSY) breaking and realize the idea of hilltop supernatural inflation in concrete particle physics models based on flipped-SU(5)and Pati-Salam models in the framework of supersymmetric grand unified theories (SUSY GUTs). The inflaton can be a flat direction including right-handed sneutrino and the waterfall field is a GUT Higgs. The spectral index is ns = 0.96 which fits very well with recent data by PLANCK satellite. There is no both thermal and non-thermal gravitino problems. Non-thermal leptogenesis can be resulted from the decay of right-handed sneutrino which plays (part of) the role of inflaton.

  6. Inflationary spectra in generalized gravity Unified forms

    CERN Document Server

    Noh, H

    2001-01-01

    The classical evolution and the quantum generation processes of the scalar- and tensor-type cosmological perturbations in the context of a broad class of generalized gravity theories are presented in unified forms. The exact forms of final spectra of the two types of structures generated during a generalized slow-roll inflation are derived. Results in generalized gravity are characterized by two additional parameters which are the coupling between gravity and field, and the nonminimal coupling in the kinetic part of the field. Our general results include widely studied gravity theories and inflation models as special cases, and show how the well known consistency relation and spectra in ordinary Einstein gravity inflation models are affected by the generalized nature of the gravity theories.

  7. A unifying conceptual model of entrepreneurial management

    DEFF Research Database (Denmark)

    Senderovitz, Martin

    This article offers a systematic analysis and synthesis of the area of entrepreneurial management. Through a presentation of two main perspectives on entrepreneurial management and a newly developed unifying conceptual entrepreneurial management model, the paper discusses a number of theoretical...... disagreements, managerial dilemmas and paradoxes. On the basis of the findings and conclusions of the study, the article contributes with and overview of the entrepreneurial management field, and offers an answer to the overall research question: What constitutes the most essential areas and challenges...... of entrepreneurial management? The paper builts on the seminal work by Stevenson (1983, 1990) and proposes a discussion and elaboration of the understanding and definition of entrepreneurial management in terms of the relationship between entrepreneurial opportunities and firm resources....

  8. A unified grand tour of theoretical physics

    CERN Document Server

    Lawrie, Ian D

    2013-01-01

    A Unified Grand Tour of Theoretical Physics invites its readers to a guided exploration of the theoretical ideas that shape our contemporary understanding of the physical world at the fundamental level. Its central themes, comprising space-time geometry and the general relativistic account of gravity, quantum field theory and the gauge theories of fundamental forces, and statistical mechanics and the theory of phase transitions, are developed in explicit mathematical detail, with an emphasis on conceptual understanding. Straightforward treatments of the standard models of particle physics and cosmology are supplemented with introductory accounts of more speculative theories, including supersymmetry and string theory. This third edition of the Tour includes a new chapter on quantum gravity, focusing on the approach known as Loop Quantum Gravity, while new sections provide extended discussions of topics that have become prominent in recent years, such as the Higgs boson, massive neutrinos, cosmological perturba...

  9. Passivity-Based Synchronization of Unified Chaotic System

    Directory of Open Access Journals (Sweden)

    K. Kemih

    2008-01-01

    Full Text Available This letter further improves and extends the work of Kemih et al. In detail, feedback passivity synchronization with only one controller for a unified chaotic system is discussed here. It is noticed that the unified system contains the noted Lorenz, Lu, and Chen systems. Numerical simulations are given to show the effectiveness of these methods.

  10. Supporting Teachers, Principals--and Students--through Unified Discipline.

    Science.gov (United States)

    Algozzine, Bob; Audette, Bob; Ellis, Edward; Marr, Mary Beth; White, Richard

    2000-01-01

    This article profiles Unified Discipline, a schoolwide systemic model of discipline that incorporates factors associated with best practices in teaching behavior and improving discipline. The four components of the program are described and include unified attitudes, expectations, correction, and team roles. Implications for practice are…

  11. Unified symmetry of non-holonomic singular systems

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In this paper, the unified symmetry of non-holonomic singular systems is studied. The differential equations of motion of the systems are given. The definition and the criterion of the unified symmetry for the systems are presented. The Noether conserved quantity, the Hojman conserved quantity and the Mei conserved quantity are obtained. An example is given to illustrate the application of the results.

  12. A Unified Scaling Law in Spiral Galaxies.

    Science.gov (United States)

    Koda; Sofue; Wada

    2000-03-01

    We investigate the origin of a unified scaling relation in spiral galaxies. Observed spiral galaxies are spread on a plane in the three-dimensional logarithmic space of luminosity L, radius R, and rotation velocity V. The plane is expressed as L~&parl0;VR&parr0;alpha in the I passband, where alpha is a constant. On the plane, observed galaxies are distributed in an elongated region which looks like the shape of a surfboard. The well-known scaling relations L-V (Tully-Fisher [TF] relation), V-R (also the TF relation), and R-L (Freeman's law) can be understood as oblique projections of the surfboard-like plane into two-dimensional spaces. This unified interpretation of the known scaling relations should be a clue to understand the physical origin of all the relations consistently. Furthermore, this interpretation can also explain why previous studies could not find any correlation between TF residuals and radius. In order to clarify the origin of this plane, we simulate formation and evolution of spiral galaxies with the N-body/smoothed particle hydrodynamics method, including cooling, star formation, and stellar feedback. Initial conditions are set to 14 isolated spheres with two free parameters, such as mass and angular momentum. The cold dark matter (h=0.5, Omega0=1) cosmology is considered as a test case. The simulations provide the following two conclusions: (1) The slope of the plane is well reproduced but the zero point is not. This zero-point discrepancy could be solved in a low-density (Omega00.5) cosmology. (2) The surfboard-shaped plane can be explained by the control of galactic mass and angular momentum.

  13. Technological Studies at Thomas Edison Middle School. Grades 6-7-8.

    Science.gov (United States)

    Foster, Patrick N.

    This technology studies curriculum for grades 6-8 is a plan for each middle school student to experience technology education for approximately 60 days (1 trimester of a 180-day school year) in each grade. Section A provides definitions; structure or content for grade-level programs with science and technology unifiers (unifying curricular…

  14. The Evolution of School Social Work Services in an Urban School District

    Science.gov (United States)

    Ayasse, Robert Henry; Stone, Susan I.

    2015-01-01

    The authors present a case history of the growth and development of school social work services between 2000 and 2012 in the San Francisco Unified School District. Responding to a gap in the literature describing growth of school social work services in local educational contexts, this case history reveals, consistent with prior research, that…

  15. Unified model for sorption, sequestration and degradation in soils and sediments

    DEFF Research Database (Denmark)

    Trapp, Stefan; Mayer, P. M.; Rein, Arno

    2011-01-01

    scenarios) full agreement, which is a verification of the model structure, mathematics and implementation of the numerical model. Validation by comparison to experimental studies is underway (see Rein et al., this session). The unified model allows the simulation of sorption, sequestration, bacterial growth....... Acknowledgement - The authors thank the European Commission for funding by the FP 7 grant No. 245226 MAGICPAH”’Molecular Approaches and MetaGenomic Investigations for optimizing Clean-up of PAH contaminated sites, and the Research School of Environmental Chemistry, Microbiology and Toxicology (RECETO) for funding...

  16. Unified model for sorption, sequestration and degradation in soils and sediments

    DEFF Research Database (Denmark)

    Trapp, Stefan; Mayer, Philipp; Rein, Arno

    scenarios) full agreement, which is a verification of the model structure, mathematics and implementation of the numerical model. Validation by comparison to experimental studies is underway (see Rein et al., this session). The unified model allows the simulation of sorption, sequestration, bacterial growth....... Acknowledgement - The authors thank the European Commission for funding by the FP 7 grant No. 245226 MAGICPAH”’Molecular Approaches and MetaGenomic Investigations for optimizing Clean-up of PAH contaminated sites, and the Research School of Environmental Chemistry, Microbiology and Toxicology (RECETO) for funding...

  17. Coral Reef and Hardbottom from Unified Florida Reef Tract Map (NODC Accession 0123059)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset is a subset of the Unified Map representing Coral reef and Hardbottom areas. Version 1.1 - December 2013. The Unified Florida Reef Tract Map (Unified...

  18. Towards a unification of unified theories of biodiversity.

    Science.gov (United States)

    McGill, Brian J

    2010-05-01

    A unified theory in science is a theory that shows a common underlying set of rules that regulate processes previously thought to be distinct. Unified theories have been important in physics including the unification of electricity and magnetism and the unification of the electromagnetic with the weak nuclear force. Surprisingly, ecology, specifically the subfields of biodiversity and macroecology, also possess not one but at least six unified theories. This is problematic as only one unified theory is desirable. Superficially, the six unified theories seem very different. However, I show that all six theories use the same three rules or assertions to describe a stochastic geometry of biodiversity. The three rules are: (1) intraspecifically individuals are clumped together; (2) interspecifically global or regional abundance varies according to a hollow curve distribution; and (3) interspecifically individuals are placed without regard to individuals of other species. These three rules appear sufficient to explain local species abundance distributions, species-area relationships, decay of similarity of distance and possibly other patterns of biodiversity. This provides a unification of the unified theories. I explore implications of this unified theory for future research.

  19. Soar and the case for unified theories of cognition.

    Science.gov (United States)

    Cooper, R; Shallice, T

    1995-05-01

    Despite the potential importance to cognitive psychology of unified theories no attempt has been made to assess concretely the methodological problems that such theorising produces. This paper addresses this issue of unified theorising, and in particular the arguments for unified theories put forward by Newell (1990). Close examination of these arguments reveals that Newell's approach does not adequately counter the difficulties which beset the grand theories of the 1930s, nor the problems of irrelevant specification which arise in modern computational psychological work. These difficulties do not prevent the development of unified theories, but they do pose serious problems, problems which it is argued can only be met by rigorous empirical testing together with extreme methodological sensitivity. The methodological concerns lead us to examine Soar, perhaps the most well-developed unified theory, from methodological, computational, and empirical perspectives. Our conclusions are that, whilst Soar represents an impressive body of research, its methodological foundations are insecure, it is ill specified as a computational/psychological theory, and under empirical testing it does not stand up to close scrutiny as a unified theory. The Soar research programme as it currently stands thus fails to meet the necessary methodological demands imposed by unified theorising.

  20. The Research of Carrier-grade Unified Communication Services

    Institute of Scientific and Technical Information of China (English)

    Jiang Nianling; Wang Xiaohua; Tao Hong

    2008-01-01

    Unified Communication (UC) has been one of the hot topics in telecommunication field, and venders introduce various platforms and products for it. Due to the diversification of platform technologies and lacking of unified application interface, curtent applications are hard to be extended and interconnected. Taking example for China Netcom NGN open service platform, this paper briefly presents how to build up carrier-grade unified communication applications under the direction of operator, which will be the reference to make fast development and large scale deployment for UC services.

  1. Pragmatic Information as a Unifying Biological Concept

    Directory of Open Access Journals (Sweden)

    Reza Maleeh

    2014-09-01

    Full Text Available This paper aims to introduce a developed reading of Roederer’s interpretation of pragmatic information as a good candidate for a Unifying Information Concept required for an as-yet-unavailable Science of Information. According to pragmatic information, information and information processing are exclusive attributes of biological systems related to the very definition of life. I will apply the notion to give new accounts in the following areas: (1 quantum interpretation: based on a modified version of David Bohm’s interpretation of quantum mechanics, I propose an ontological, information-based interpretation of quantum mechanics which, unlike Roederer’s interpretation, satisfies all conditions of pragmatic information; (2 artificial intelligence: the notion successfully distinguishes natural living systems from artifacts and natural non-living systems, providing a context to pose an information-based argument against the thesis of Strong Artificial Intelligence; (3 phenomenal consciousness: I will use pragmatic information to modify and update Chalmers’s Double-aspect Theory of Information to be explanatorily more powerful regarding the physical aspect of his theory; (4 causation: based on pragmatic information, I pose a new account of causation which differentiates causation in biology from causation in natural abiotic world.

  2. Experimental Validation of the Unified Theory

    Directory of Open Access Journals (Sweden)

    Erol Cubukcu

    2006-09-01

    Full Text Available

    Hatsopoulos and Gyftopoulos (1976a,b,c,d founded the Unified Quantum Theory of Mechanics and Thermodynamics. This theory encompasses both quantum mechanics and thermodynamics within a single mathematical framework. Unlike statistical approaches, it treats thermodynamics as a non-statistical (hence, a physical theory and is intended to describe all reversible and irreversible phenomena. Unfortunately, the theory has long been criticized for not bringing anything new beyond statistical quantum thermodynamics. To break through this misconception that thermodynamics is a statistical theory, experimental validation at a microscopic scale, where statistical effects are negligible, would be fruitful. In this paper, which is based on the dissertation work of the author (1993, experiments that were previously reported are investigated within the framework of the new theory. It is argued that they provide an undeniable confirmation of the theory and the existence of irreversibility at the microscopic scale.

    • An initial version of this paper was published in
      July of 2006 in the proceedings of ECOS’06, Aghia
      Pelagia, Crete, Greece. 

  3. A Unified Taxonomy for Ciliary Dyneins

    Science.gov (United States)

    Hom, Erik F.Y.; Witman, George B.; Harris, Elizabeth H.; Dutcher, Susan K.; Kamiya, Ritsu; Mitchell, David R.; Pazour, Gregory J.; Porter, Mary E.; Sale, Winfield S.; Wirschell, Maureen; Yagi, Toshiki; King, Stephen M.

    2011-01-01

    The formation and function of eukaryotic cilia/flagella require the action of a large array of dynein microtubule motor complexes. Due to genetic, biochemical, and microscopic tractability, Chlamydomonas reinhardtii has become the premier model system in which to dissect the role of dyneins in flagellar assembly, motility, and signaling. Currently, fifty-four proteins have been described as components of various Chlamydomonas flagellar dyneins or as factors required for their assembly in the cytoplasm and/or transport into the flagellum; orthologues of nearly all these components are present in other ciliated organisms including humans. For historical reasons, the nomenclature of these diverse dynein components and their corresponding genes, mutant alleles and orthologues has become extraordinarily confusing. Here, we unify Chlamydomonas dynein gene nomenclature and establish a systematic classification scheme based on structural properties of the encoded proteins. Furthermore, we provide detailed tabulations of the various mutant alleles and protein aliases that have been used and explicitly define the correspondence with orthologous components in other model organisms and humans. PMID:21953912

  4. Constraining Logotropic Unified Dark Energy Models

    CERN Document Server

    Ferreira, V M C

    2016-01-01

    A unification of dark matter and dark energy in terms of a logotropic perfect dark fluid has recently been proposed, where deviations with respect to the standard $\\Lambda {\\rm CDM}$ model are dependent on a single parameter $B$. In this paper we show that the requirement that the linear growth of cosmic structures on comoving scales larger than $8 h^{-1} \\, {\\rm Mpc}$ is not significantly affected with respect to the standard $\\Lambda {\\rm CDM}$ result provides the strongest constraint to date on the model ($B <6 \\times 10^{-7}$), an improvement of more than three orders of magnitude over previous constraints on the value of $B$. We further show that this constraint rules out the logotropic Unified Dark Energy model as a possible solution to the small scale problems of the $\\Lambda$CDM model, including the cusp problem of Dark Matter halos or the missing satellite problem, as well as the original version of the model where the Planck energy density was taken as one of the two parameters characterizing the...

  5. Texture Repairing by Unified Low Rank Optimization

    Institute of Scientific and Technical Information of China (English)

    Xiao Liang; Xiang Ren; Zhengdong Zhang; Yi Ma

    2016-01-01

    In this paper, we show how to harness both low-rank and sparse structures in regular or near-regular textures for image completion. Our method is based on a unified formulation for both random and contiguous corruption. In addition to the low rank property of texture, the algorithm also uses the sparse assumption of the natural image: because the natural image is piecewise smooth, it is sparse in certain transformed domain (such as Fourier or wavelet transform). We combine low-rank and sparsity properties of the texture image together in the proposed algorithm. Our algorithm based on convex optimization can automatically and correctly repair the global structure of a corrupted texture, even without precise information about the regions to be completed. This algorithm integrates texture rectification and repairing into one optimization problem. Through extensive simulations, we show our method can complete and repair textures corrupted by errors with both random and contiguous supports better than existing low-rank matrix recovery methods. Our method demonstrates significant advantage over local patch based texture synthesis techniques in dealing with large corruption, non-uniform texture, and large perspective deformation.

  6. Toward a unified chromatic induction model.

    Science.gov (United States)

    Otazu, Xavier; Parraga, C Alejandro; Vanrell, Maria

    2010-10-01

    In a previous work (X. Otazu, M. Vanrell, & C. A. Párraga, 2008b), we showed how several brightness induction effects can be predicted using a simple multiresolution wavelet model (BIWaM). Here we present a new model for chromatic induction processes (termed Chromatic Induction Wavelet Model or CIWaM), which is also implemented on a multiresolution framework and based on similar assumptions related to the spatial frequency and the contrast surround energy of the stimulus. The CIWaM can be interpreted as a very simple extension of the BIWaM to the chromatic channels, which in our case are defined in the MacLeod-Boynton (lsY) color space. This new model allows us to unify both chromatic assimilation and chromatic contrast effects in a single mathematical formulation. The predictions of the CIWaM were tested by means of several color and brightness induction experiments, which showed an acceptable agreement between model predictions and psychophysical data.

  7. Aspects Of Grand Unified And String Phenomenology

    CERN Document Server

    Walker, J W

    2005-01-01

    Explored in this report is the essential interconnectedness of Grand Unified and String Theoretic Phenomenology. In order to extract a modeled connection to low-energy physics from the context of superstring theory, it is presently necessary to input some preferred region of parameter space in which to search. This need may be well filled by a parallel study of Grand Unification, which is by contrast in immediate proximity to a wealth of experimental data. The favored GUT so isolated may then reasonably transfer this phenomenological correlation to a string embedding, receiving back by way of trade a greater sense of primary motivation, and potentially enhanced predictability for parameters taken as input in a particle physics context. The Flipped SU(5) GUT will be our preferred framework in which to operate and first receives an extended study in a non-string derived setting. Of particularly timely interest are predictions for super-particle mass ranges and the interrelated question of proton decay lifetime....

  8. New unifying procedure for PC index calculations.

    Science.gov (United States)

    Stauning, P.

    2012-04-01

    The Polar Cap (PC) index is a controversial topic within the IAGA scientific community. Since 1997 discussions of the validity of the index to be endorsed as an official IAGA index have ensued. Currently, there are now the three separate PC index versions constructed from the different procedures used at the three institutes: the Arctic and Antarctic Research Institute (AARI), the Danish Meteorological Institute (DMI), and the Danish National Space Institute (DTU Space). It is demonstrated in this presentation, that two consistent unifying procedures can be built from the best elements of the three different versions. One procedure uses a set of coefficients aimed at the calculation of final PC index values to be accepted by IAGA. The other procedure uses coefficients aimed at on-line real-time production of preliminary PC index values for Space Weather monitoring applications. For each of the two cases the same procedure is used for the northern (PCN) and the southern (PCS) polar cap indices, and the derived PCN and PCS coefficients are similar.

  9. Structural basis unifying diverse GTP hydrolysis mechanisms.

    Science.gov (United States)

    Anand, Baskaran; Majumdar, Soneya; Prakash, Balaji

    2013-02-12

    Central to biological processes is the regulation rendered by GTPases. Until recently, the GTP hydrolysis mechanism, exemplified by Ras-family (and G-α) GTPases, was thought to be universal. This mechanism utilizes a conserved catalytic Gln supplied "in cis" from the GTPase and an arginine finger "in trans" from a GAP (GTPase activating protein) to stabilize the transition state. However, intriguingly different mechanisms are operative in structurally similar GTPases. MnmE and dynamin like cation-dependent GTPases lack the catalytic Gln and instead employ a Glu/Asp/Ser situated elsewhere and in place of the arginine finger use a K(+) or Na(+) ion. In contrast, Rab33 possesses the Gln but does not utilize it for catalysis; instead, the GAP supplies both a catalytic Gln and an arginine finger in trans. Deciphering the underlying principles that unify seemingly unrelated mechanisms is central to understanding how diverse mechanisms evolve. Here, we recognize that steric hindrance between active site residues is a criterion governing the mechanism employed by a given GTPase. The Arf-ArfGAP structure is testimony to this concept of spatial (in)compatibility of active site residues. This understanding allows us to predict an as yet unreported hydrolysis mechanism and clarifies unexplained observations about catalysis by Rab11 and the need for HAS-GTPases to employ a different mechanism. This understanding would be valuable for experiments in which abolishing GTP hydrolysis or generating constitutively active forms of a GTPase is important.

  10. Randomized central limit theorems: A unified theory

    Science.gov (United States)

    Eliazar, Iddo; Klafter, Joseph

    2010-08-01

    The central limit theorems (CLTs) characterize the macroscopic statistical behavior of large ensembles of independent and identically distributed random variables. The CLTs assert that the universal probability laws governing ensembles’ aggregate statistics are either Gaussian or Lévy, and that the universal probability laws governing ensembles’ extreme statistics are Fréchet, Weibull, or Gumbel. The scaling schemes underlying the CLTs are deterministic—scaling all ensemble components by a common deterministic scale. However, there are “random environment” settings in which the underlying scaling schemes are stochastic—scaling the ensemble components by different random scales. Examples of such settings include Holtsmark’s law for gravitational fields and the Stretched Exponential law for relaxation times. In this paper we establish a unified theory of randomized central limit theorems (RCLTs)—in which the deterministic CLT scaling schemes are replaced with stochastic scaling schemes—and present “randomized counterparts” to the classic CLTs. The RCLT scaling schemes are shown to be governed by Poisson processes with power-law statistics, and the RCLTs are shown to universally yield the Lévy, Fréchet, and Weibull probability laws.

  11. LFRic: Building a new Unified Model

    Science.gov (United States)

    Melvin, Thomas; Mullerworth, Steve; Ford, Rupert; Maynard, Chris; Hobson, Mike

    2017-04-01

    The LFRic project, named for Lewis Fry Richardson, aims to develop a replacement for the Met Office Unified Model in order to meet the challenges which will be presented by the next generation of exascale supercomputers. This project, a collaboration between the Met Office, STFC Daresbury and the University of Manchester, builds on the earlier GungHo project to redesign the dynamical core, in partnership with NERC. The new atmospheric model aims to retain the performance of the current ENDGame dynamical core and associated subgrid physics, while also enabling a far greater scalability and flexibility to accommodate future supercomputer architectures. Design of the model revolves around a principle of a 'separation of concerns', whereby the natural science aspects of the code can be developed without worrying about the underlying architecture, while machine dependent optimisations can be carried out at a high level. These principles are put into practice through the development of an autogenerated Parallel Systems software layer (known as the PSy layer) using a domain-specific compiler called PSyclone. The prototype model includes a re-write of the dynamical core using a mixed finite element method, in which different function spaces are used to represent the various fields. It is able to run in parallel with MPI and OpenMP and has been tested on over 200,000 cores. In this talk an overview of the both the natural science and computational science implementations of the model will be presented.

  12. A unified grand tour of theoretical physics

    CERN Document Server

    Griffiths, J

    2002-01-01

    Anyone offering a grand tour is faced with several options. Should they concentrate on what may be considered to be essential features, or should they attempt to present a brief glimpse of almost everything? The present offering is a compromise between these two extremes. The area considered - theoretical physics - is now such a vast subject that some kind of compromise is essential. Indeed, the field is now so wide that few could even attempt to review it in a single-authored work. My task here is to assess how well this book has succeeded in its main aim of providing a unified (though introductory) tour of this subject. Constrained within a single volume, this is clearly not an updated Landau-Lifschitz. It cannot be expected to take any particular topic to the level of recent research. Nevertheless, it does seem to cover the broad range of essential topics which now constitute the subject. It starts (most appropriately in my opinion) with geometry. It then covers classical physics, general relativity and qu...

  13. Unified water isotherms for clayey porous materials

    Science.gov (United States)

    Revil, A.; Lu, N.

    2013-09-01

    We provide a unified model for the soil-water retention function, including the effect of bound and capillary waters for all types of soils, including clayey media. The model combines a CEC-normalized isotherm describing the sorption of the bound water (and the filling of the trapped porosity) and the van Genuchten model to describe the capillary water sorption retention but ignore capillary condensation. For the CEC-normalized isotherm, we tested both the BET and Freundlich isotherms, and we found that the Freundlich is more suitable than the BET isotherm in fitting the data. It is also easier to combine the Freundlich isotherm with the van Genuchten model. The new model accounts for (1) the different types of clay minerals, (2) the different types of ions sorbed in the Stern layer and on the basal planes of 2:1 clays, and (3) the pore size distribution. The model is validated with different data sets, including mixtures of kaolinite and bentonite. The model parameters include two exponents (the pore size exponent of the van Genuchten model and the exponent of the Freundlich isotherm), the capillary entry pressure, and two critical water contents. The first critical water content is the water content at saturation (porosity), and the second is the maximum water content associated with adsorption forces, including the trapped nonbound water.

  14. Sensor Deployment and Relocation: A Unified Scheme

    Institute of Scientific and Technical Information of China (English)

    Michele Garetto; Marco Gribaudo; Carla-Fabiana Chiasserini; Emilio Leonardi

    2008-01-01

    Sensor networks are envisioned to revolutionize our daily life by ubiquitously monitoring our environment and/or adjusting it to suit our needs. Recent progress in robotics and low-power embedded systems has made it possible to add mobility to small, light, low-cost sensors to be used in teams or swarms. Augmenting static sensor networks with mobile nodes addresses many design challenges that exist in traditional static sensor networks. This paper addresses the problem of topology control in mobile wireless networks. Limitations in communication, computation and energy capabilities push towards the adoption of distributed, energy-efficient solutions to perform self-deployment and relocation of the nodes. We develop a unified, distributed algorithm that has the following features. During deployment, our algorithm yields a regular tessellation of the geographical area with a given node density, called monitoring configuration. Upon the occurrence of a physical phenomenon, network nodes relocate themselves so as to properly sample and control the event, while maintaining the network connectivity. Then, as soon as the event ends, all nodes return to the monitoring configuration. To achieve these goals, we use a virtual force-based strategy which proves to be very effective even when compared to an optimal centralized solution. We assess the performance of our approach in the presence of events with different shapes, and we investigate the transient behavior of our algorithm. This allows us to evaluate the effectiveness and the response time of the proposed solution under various environmental conditions.

  15. A unified model for yeast transcript definition.

    Science.gov (United States)

    de Boer, Carl G; van Bakel, Harm; Tsui, Kyle; Li, Joyce; Morris, Quaid D; Nislow, Corey; Greenblatt, Jack F; Hughes, Timothy R

    2014-01-01

    Identifying genes in the genomic context is central to a cell's ability to interpret the genome. Yet, in general, the signals used to define eukaryotic genes are poorly described. Here, we derived simple classifiers that identify where transcription will initiate and terminate using nucleic acid sequence features detectable by the yeast cell, which we integrate into a Unified Model (UM) that models transcription as a whole. The cis-elements that denote where transcription initiates function primarily through nucleosome depletion, and, using a synthetic promoter system, we show that most of these elements are sufficient to initiate transcription in vivo. Hrp1 binding sites are the major characteristic of terminators; these binding sites are often clustered in terminator regions and can terminate transcription bidirectionally. The UM predicts global transcript structure by modeling transcription of the genome using a hidden Markov model whose emissions are the outputs of the initiation and termination classifiers. We validated the novel predictions of the UM with available RNA-seq data and tested it further by directly comparing the transcript structure predicted by the model to the transcription generated by the cell for synthetic DNA segments of random design. We show that the UM identifies transcription start sites more accurately than the initiation classifier alone, indicating that the relative arrangement of promoter and terminator elements influences their function. Our model presents a concrete description of how the cell defines transcript units, explains the existence of nongenic transcripts, and provides insight into genome evolution.

  16. Towards gauge unified, supersymmetric hidden strong dynamics

    CERN Document Server

    Chiang, Cheng-Wei; Ye, Fang

    2016-01-01

    We consider a class of models with extra complex scalars that are charged under both the Standard Model and a hidden strongly coupled $SU(N)_H$ gauge sector, and discuss the scenarios where the new scalars are identified as the messenger fields that mediate the spontaneously broken supersymmetries from the hidden sector to the visible sector. The new scalars are embedded into 5-plets and 10-plets of an $SU(5)_V$ gauge group that potentially unifies the Standard Model gauge groups. They also form a tower of bound states via hidden strong dynamics around the TeV scale. The Higgs bosons remain as elementary particles. Quadratically divergent contributions to the Higgs mass from the Standard Model fermions are canceled by the new scalar contributions to alleviate the fine-tuning problem. We also discuss a supersymmetrized version of this class of models, consisting of the minimal supersymmetric Standard Model plus extra chiral multiplets where the new scalars reside. Due to the hidden strong force, the new low-en...

  17. A Unifying Theory for Camera Calibration.

    Science.gov (United States)

    Ramalingam, SriKumar; Sturm, Peter

    2016-07-19

    This paper proposes a unified theory for calibrating a wide variety of camera models such as pinhole, fisheye, cata-dioptric, and multi-camera networks. We model any camera as a set of image pixels and their associated camera rays in space. Every pixel measures the light traveling along a (half-) ray in 3-space, associated with that pixel. By this definition, calibration simply refers to the computation of the mapping between pixels and the associated 3D rays. Such a mapping can be computed using images of calibration grids, which are objects with known 3D geometry, taken from unknown positions. This general camera model allows to represent non-central cameras; we also consider two special subclasses, namely central and axial cameras. In a central camera, all rays intersect in a single point, whereas the rays are completely arbitrary in a non-central one. Axial cameras are an intermediate case: the camera rays intersect a single line. In this work, we show the theory for calibrating central, axial and non-central models using calibration grids, which can be either three-dimensional or planar.

  18. Argumentation and Inference: A Unified Approach

    Directory of Open Access Journals (Sweden)

    Christophe Fouqueré

    2013-12-01

    Full Text Available We propose in this paper to use Ludics as a unified framework for the analysis of dialogue and the reasoning system. Not only is Ludics a logical theory, but it may also be built by means of concepts of game theory. We first present the main concepts of Ludics. A design is an abstraction and a generalization of the concept of proof. Interaction between designs is equivalent to cut elimination or modus ponens in logical theories. It appears to be a natural means for representing dialogues and also for reasoning. A design is a set of sequences of alternate actions, similar to a move in game theory. We apply Ludics to argumentative dialogues. We discuss how to model the speech acts of argumentative dialogues in terms of dialogue acts. A dialogue act is given by a Ludics action together with the expression that reveals the action in a turn of speech. We show also how arguments may be stored in a commitment state used for reasoning. Finally we revisit an example of juridical dialogue that has been analyzed by Prakken in a different framework.

  19. A unified optimization approach for the enhancement of Available Transfer Capability and Congestion Management using unified power flow controller

    Directory of Open Access Journals (Sweden)

    Ramasubramanian Jayashree

    2008-01-01

    Full Text Available This paper proposes a unified optimization model and algorithm for assessing Available Transfer Capability (ATC and carrying out Congestion Management (CM in a Deregulated power system handling both pool and bilateral transactions. It uses a power injection model for Unified Power Flow Controller (UPFC, DC load flow model for power network and repeated linear programming technique for optimization. The DC model enforces the line operating lines in MW. A computer package has been developed and the effectiveness of the proposed unified method has been verified by solving 4 bus and an IEEE 30 bus systems. The results demonstrate the effectiveness of UPFC control on ATC enhancement and Congestion Management.

  20. Unified Nonlinear Flight Dynamics and Aeroelastic Simulator Tool Project

    Data.gov (United States)

    National Aeronautics and Space Administration — ZONA Technology, Inc. (ZONA) proposes a R&D effort to develop a Unified Nonlinear Flight Dynamics and Aeroelastic Simulator (UNFDAS) Tool that will combine...

  1. A unified viscoplasticity constitutive model based on irreversible thermodynamics

    Institute of Scientific and Technical Information of China (English)

    LIU ChangChun; LV HeXiang; GUAN Ping

    2008-01-01

    A unified viscoplasticity constitutive model for metal materials is developed within the framework of irreversible thermodynamics, and an expression for the Helmholtz free energy function involving the parameters reflecting kinematic hardening and isotropic hardening is given. At the same time a non-associated flow potential function including the corresponding state variables is also given, from which the flow equation and the evolution equations of the internal state variables are derived. Thus, a general theoretical framework constructing a unified viscoplasticity con-stitutive model is given. Compared with the typical unified viscoplasticity constitu-tive models, the presented model evidently satisfies the irreversible thermody-namics laws. Moreover, this method not only provides a new theoretical foundation for further development of the unified viscoplasticity constitutive model, but also gives a new theoretical framework for the stress-strain analysis of more materials.

  2. A Unified Mathematical Definition of Classical Information Retrieval.

    Science.gov (United States)

    Dominich, Sandor

    2000-01-01

    Presents a unified mathematical definition for the classical models of information retrieval and identifies a mathematical structure behind relevance feedback. Highlights include vector information retrieval; probabilistic information retrieval; and similarity information retrieval. (Contains 118 references.) (Author/LRW)

  3. Electrostatics and confinement in Einstein's unified field theory

    OpenAIRE

    Antoci, S.; Liebscher, D. -E.; Mihich, L.

    2007-01-01

    A way for appending sources at the right-hand sides of the field equations of Einstein's unified field theory is recalled. Two exact solutions endowed with point sources in equilibrium are shown, and their physical meaning is discussed.

  4. A unified viscoplasticity constitutive model based on irreversible thermodynamics

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A unified viscoplasticity constitutive model for metal materials is developed within the framework of irreversible thermodynamics, and an expression for the Helmholtz free energy function involving the parameters reflecting kinematic hardening and isotropic hardening is given. At the same time a non-associated flow potential function including the corresponding state variables is also given, from which the flow equation and the evolution equations of the internal state variables are derived. Thus, a general theoretical framework constructing a unified viscoplasticity constitutive model is given. Compared with the typical unified viscoplasticity constitutive models, the presented model evidently satisfies the irreversible thermodynamics laws. Moreover, this method not only provides a new theoretical foundation for further development of the unified viscoplasticity constitutive model, but also gives a new theoretical framework for the stress-strain analysis of more materials.

  5. Influence of Deterministic Attachments for Large Unifying Hybrid Network Model

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Large unifying hybrid network model (LUHPM) introduced the deterministic mixing ratio fd on the basis of the harmonious unification hybrid preferential model, to describe the influence of deterministic attachment to the network topology characteristics,

  6. Decomposition of Data Mining Algorithms into Unified Functional Blocks

    Directory of Open Access Journals (Sweden)

    Ivan Kholod

    2016-01-01

    Full Text Available The present paper describes the method of creating data mining algorithms from unified functional blocks. This method splits algorithms into independently functioning blocks. These blocks must have unified interfaces and implement pure functions. The method allows us to create new data mining algorithms from existing blocks and improves the existing algorithms by optimizing single blocks or the whole structure of the algorithms. This becomes possible due to a number of important properties inherent in pure functions and hence functional blocks.

  7. Interactive Unified Dark Energy and Dark Matter from Scalar Fields

    OpenAIRE

    Benisty, David; Guendelman, E. I.

    2017-01-01

    Here we generalize ideas of unified Dark Matter Dark Energy in the context of Two Measure Theories and of Dynamical space time Theories. In Two Measure Theories one uses metric independent volume elements and this allows to construct unified Dark Matter Dark Energy, where the cosmological constant appears as an integration constant associated to the eq. of motion of the measure fields. The Dynamical space time Theories generalize the Two Measure Theories by introducing a vector field whose eq...

  8. Unified Power Quality Conditioner for voltage and current compensation

    OpenAIRE

    P.Annapandi; Dr.M.Rajaram

    2012-01-01

    This paper deals with a Unified Power Quality Conditioner (UPQC) for load balancing, power factorcorrection, voltage regulation, voltage and current harmonics mitigation, mitigation of voltage sag, swelland voltage dip in a three-phase three-wire distribution system for different combinations of linear and nonlinear loads.The unified power quality conditioner (UPQC) is a combination of back to back connected shunt and series active power filters (APFs) to a common DC link voltage, which compe...

  9. Teaching a Unified View of Science.

    Science.gov (United States)

    Carroll, Margaret Kelly; Smith, Kay Monroe

    1985-01-01

    Reviews the proposals of Paul DeHart Hurd for improving science education in elementary schools, while ensuring that it is compatible with the goals of Catholic education. Suggests relating science to life situations, exploring broad applications of the scientific method, and making science instruction a process of discovery. (DMM)

  10. Inclusion: The Unifying Thread for Fragmented Metaphors

    Science.gov (United States)

    Doyle, Lynn H.

    2004-01-01

    The fabric of educational leadership is changing. Murphy (2001) has suggested three new metaphors for educational leaders: moral stewards, builders of communities, and educators for school improvement. However, shifting priorities and contradictions between these metaphors could result in fragmentation within the field. This article discusses…

  11. Unifying the Algebra for All Movement

    Science.gov (United States)

    Eddy, Colleen M.; Quebec Fuentes, Sarah; Ward, Elizabeth K.; Parker, Yolanda A.; Cooper, Sandi; Jasper, William A.; Mallam, Winifred A.; Sorto, M. Alejandra; Wilkerson, Trena L.

    2015-01-01

    There exists an increased focus on school mathematics, especially first-year algebra, due to recent efforts for all students to be college and career ready. In addition, there are calls, policies, and legislation advocating for all students to study algebra epitomized by four rationales of the "Algebra for All" movement. In light of this…

  12. Unifying the Algebra for All Movement

    Science.gov (United States)

    Eddy, Colleen M.; Quebec Fuentes, Sarah; Ward, Elizabeth K.; Parker, Yolanda A.; Cooper, Sandi; Jasper, William A.; Mallam, Winifred A.; Sorto, M. Alejandra; Wilkerson, Trena L.

    2015-01-01

    There exists an increased focus on school mathematics, especially first-year algebra, due to recent efforts for all students to be college and career ready. In addition, there are calls, policies, and legislation advocating for all students to study algebra epitomized by four rationales of the "Algebra for All" movement. In light of this…

  13. A unified multiwavelength model of galaxy formation

    Science.gov (United States)

    Lacey, Cedric G.; Baugh, Carlton M.; Frenk, Carlos S.; Benson, Andrew J.; Bower, Richard G.; Cole, Shaun; Gonzalez-Perez, Violeta; Helly, John C.; Lagos, Claudia D. P.; Mitchell, Peter D.

    2016-11-01

    We present a new version of the GALFORM semi-analytical model of galaxy formation. This brings together several previous developments of GALFORM into a single unified model, including a different initial mass function (IMF) in quiescent star formation and in starbursts, feedback from active galactic nuclei suppressing gas cooling in massive haloes, and a new empirical star formation law in galaxy discs based on their molecular gas content. In addition, we have updated the cosmology, introduced a more accurate treatment of dynamical friction acting on satellite galaxies, and updated the stellar population model. The new model is able to simultaneously explain both the observed evolution of the K-band luminosity function and stellar mass function, and the number counts and redshift distribution of sub-mm galaxies selected at 850 μm. This was not previously achieved by a single physical model within the Λcold dark matter framework, but requires having an IMF in starbursts that is somewhat top-heavy. The new model is tested against a wide variety of observational data covering wavelengths from the far-UV to sub-mm, and redshifts from z = 0 to 6, and is found to be generally successful. These observations include the optical and near-infrared (IR) luminosity functions, H I mass function, fraction of early type galaxies, Tully-Fisher, metallicity-luminosity and size-luminosity relations at z = 0, as well as far-IR number counts, and far-UV luminosity functions at z ˜ 3-6. Discrepancies are, however, found in galaxy sizes and metallicities at low luminosities, and in the abundance of low-mass galaxies at high-z, suggesting the need for a more sophisticated model of supernova feedback.

  14. The High School student’s journey:

    DEFF Research Database (Denmark)

    Gholamian, Jamshid

    of spatial and temporal conditions comprise a basis for a unified whole – the student - and her or his travel through high school. The Journey describes what I call a chronotopic identity that students appropriate on their journey through high school – a chronotope of crisis and break – a chronotope...

  15. The Strategy of In-School Administration.

    Science.gov (United States)

    Karklina, S. E.

    1989-01-01

    Advocates applying the theories of Anton S. Makarenko, an early influential Soviet educator, to the practice of school administration in the Soviet Union. Reviews Makarenko's theories, focusing on the establishment of a unified labor collective school, responsible for students' political socialization and character development. Stresses the…

  16. An Evaluation of Decentralization in a Large School District.

    Science.gov (United States)

    Silberman, Harry F.

    In October 1975, the School Board of the Los Angeles Unified School District appointed a Citizen's Committee to conduct an appraisal of the management of the school district. This Citizen's Management Review Committee (CMRC) organized itself into five subcommittees: Management, Policy, Personnel, Budget, and Decentralization. The Decentralization…

  17. Technology Finds Its Place in Silicon Valley Schools

    Science.gov (United States)

    Hundley, Paula; Scigliano, Marie

    2012-01-01

    Technology today is poised to usher in the best of times. Exploring what other districts do highlights the common themes as well as the unique challenges. Three very different districts in Silicon Valley--Portola Valley School District, Campbell Union School District and San Jose Unified School District--explain the strategies they use to enhance…

  18. Theory Z School: Beyond Effectiveness.

    Science.gov (United States)

    George, Paul S.

    American schools might improve their performance by emulating certain successful businesses that, while distinctly American, have much in common with Japanese corporations. William Ouchi attributes Japanese business success to worker involvement; the typical Japanese corporation, he asserts, unifies its employees around a corporate philosophy…

  19. Data, Our GPS

    Science.gov (United States)

    Smith, Rich; Johnson, Marcus; Thompson, Karen D.

    2012-01-01

    A low-performing California school district experienced a dramatic turnaround when faculty members began studying student assessment data and working together to ensure students had the support they needed. Sanger Unified School District began its reform journey in 2004 when district leaders launched an effort to focus deliberately on student…

  20. Data, Our GPS

    Science.gov (United States)

    Smith, Rich; Johnson, Marcus; Thompson, Karen D.

    2012-01-01

    A low-performing California school district experienced a dramatic turnaround when faculty members began studying student assessment data and working together to ensure students had the support they needed. Sanger Unified School District began its reform journey in 2004 when district leaders launched an effort to focus deliberately on student…

  1. Nothing From Everything- A Unified Theory

    Science.gov (United States)

    Mehra, Vijay Kumar

    2016-07-01

    Nothing From Everything-A Unified Theory is a philosophical insight into principles of nature through principle of complementary spontaneity and principle of vertical continuity. This work is intended to explain various cosmological phenomena in light of behaviour of particles in range of their respective and relative speed of light. This theory explains creation of Universe from nothing or zero spacetime through scalar energy field collapsing into Higgs field resulting into giving mass to various particles. The energy particles taking origin from nothing while moving away from zero space-time would create space-time of their own order because energy/matter needs space to exist. The particles while moving away from zero space-time would end up in breaking symmetry of matter/energy at their mass infinity (highest possible mass of any particle, which is function of speed of spin). This break in symmetry would lead to curving of particles upon themselves and hence would lead to creation of antiparticles going back in time towards zero spacetime. Therefore the Universe could have been created by alternate layers of particles and antiparticles and also alternate layers of matter and antimatter with decelerating speed of light, which would lead to creation a closed and flat Universe. With increase in mass of Universe (creation of more and more Universe's matter from nothing), the gravitational force of Universe is bound to increase and hence with quantum by quantum increase in gravity, it would apply brakes on relative speed of photon/light out of its reference frame or designated space and hence speed of photon would decrease. If closed and flat Universe was created with decelerating speed of light, then such Universe is bound to contract back with accelerating speed of light which would have inverse impact on gravitational constant across various spacetime zones of Universe. And hence mass bodies would drift away spontaneously purely on basis and proportional to

  2. Self-reported study habits for enhancing medical students’ performance in the National Medical Unified Examination

    Science.gov (United States)

    Idris, Amr; Al Saadi, Tareq; Edris, Basel; Sawaf, Bisher; Zakaria, Mhd. Ismael; Alkhatib, Mahmoud; Turk, Tarek

    2016-01-01

    Background: The National Medical Unified Examination (NMUE) is currently required for graduation, joining postgraduate medical training, and practicing medicine in Syria. Objective: To investigate self-reported study habits that correlate with high performance on the NMUE. Methods: First through 3rd year residents at the three main hospitals in Damascus, Syria, were asked to complete a retrospective cross-sectional survey investigating their study habits and previous scores. Results: Significantly higher score was associated with >15 study h/day and allocating 1–40% of study time for practicing questions. Mean NMUE score was not significantly different in relation to preparation months for examination or for those who reported spending all their time studying alone compared with spending any amount of time in a group setting. Scores of 231–240 on the Syrian scientific high school exam correlated with significantly higher NMUE performance compared with fewer scores, except scores of 221–230. For every 10 point increase in medical school cumulative grades, the NMUE score increased 3.6 (95% confidence interval 2.5–4.8). Conclusion: The NMUE score was significantly affected by hours spent studying per day, number of practice questions completed, percentage of study time allocated for doing questions, Syrian scientific high school exam scores, and the cumulative medical school class grades. It was not significantly affected by preparation months or studying in a group setting. More studies are needed to further describe and investigate the factors that might affect performance in the NMUE. PMID:27144140

  3. Mechanical systems a unified approach to vibrations and controls

    CERN Document Server

    Gans, Roger F

    2015-01-01

    This essential textbook covers analysis and control of engineering mechanisms, which include almost any apparatus with moving parts used in daily life, from musical instruments to robots. The text  presents both vibrations and controls with considerable breadth and depth using a unified notation. It strikes a nice balance between the analytical and the practical.  This text contains enough material for a two semester sequence, but it can also be used in a single semester course combining the two topics. Mechanical Systems: A Unified Approach to Vibrations and Controls presents a common notation and approach to these closely related areas. Examples from the both vibrations and controls components are integrated throughout this text. This book also: ·         Presents a unified approach to vibrations and controls, including an excellent diagram that simultaneously discusses embedding classical vibrations (mechanical systems) in a discussion of models, inverse models, and open and closed loop control ...

  4. Trilepton Signal of Grand Unified Models at the Tevatron

    CERN Document Server

    Accomando, E; Dutta, B

    2000-01-01

    At the Tevatron, the most promising channel to detect supersymmetry is three leptons plus missing energy, where the leptons are $e$'s and/or $\\mu$'s. This final state appears from the production of chargino and second lighetst neutralino. However in grand unified models with universal scalar masses at the grand unified scale, this final state mostly consists of $\\tau$'s which are hard to detect. We show that for some regions of non universality in the scalar masses at the GUT scale based on unifying groups like SU(5) or SO(10), the final state mostly consists of 3$l$+${\\rlap/E}_T$ and $\\tau ll$+${\\rlap/E}_T$. The first mode has very high detection efficiency and the second one is expected to have high detection efficency as well. We also show that these models can have enough events in these modes to be detected in RUN II.

  5. Unified framework and algorithm for quantized compressed sensing

    CERN Document Server

    Yang, Zai; Zhang, Cishen

    2012-01-01

    Compressed sensing (CS) studies the recovery of high dimensional signals from their low dimensional linear measurements under a sparsity prior. This paper is focused on the CS problem with quantized measurements. There have been research results dealing with different scenarios including a single/multiple bits per measurement, noiseless/noisy environment, and an unsaturated/saturated quantizer. While the existing methods are only for one or more specific cases, this paper presents a framework to unify all the above mentioned scenarios of the quantized CS problem. Under the unified framework, a variational Bayesian inference based algorithm is proposed which is applicable to the signal recovery of different application cases. Numerical simulations are carried out to illustrate the improved signal recovery accuracy of the unified algorithm in comparison with state-of-the-art methods for both multiple and single bit CS problems.

  6. Disturbed state concept as unified constitutive modeling approach

    Directory of Open Access Journals (Sweden)

    Chandrakant S. Desai

    2016-06-01

    Full Text Available A unified constitutive modeling approach is highly desirable to characterize a wide range of engineering materials subjected simultaneously to the effect of a number of factors such as elastic, plastic and creep deformations, stress path, volume change, microcracking leading to fracture, failure and softening, stiffening, and mechanical and environmental forces. There are hardly available such unified models. The disturbed state concept (DSC is considered to be a unified approach and is able to provide material characterization for almost all of the above factors. This paper presents a description of the DSC, and statements for determination of parameters based on triaxial, multiaxial and interface tests. Statements of DSC and validation at the specimen level and at the boundary value problem levels are also presented. An extensive list of publications by the author and others is provided at the end. The DSC is considered to be a unique and versatile procedure for modeling behaviors of engineering materials and interfaces.

  7. Disturbed state concept as unified constitutive modeling approach

    Institute of Scientific and Technical Information of China (English)

    Chandrakant S. Desai

    2016-01-01

    A unified constitutive modeling approach is highly desirable to characterize a wide range of engineering materials subjected simultaneously to the effect of a number of factors such as elastic, plastic and creep deformations, stress path, volume change, microcracking leading to fracture, failure and softening, stiffening, and mechanical and environmental forces. There are hardly available such unified models. The disturbed state concept (DSC) is considered to be a unified approach and is able to provide material characterization for almost all of the above factors. This paper presents a description of the DSC, and statements for determination of parameters based on triaxial, multiaxial and interface tests. Statements of DSC and validation at the specimen level and at the boundary value problem levels are also presented. An extensive list of publications by the author and others is provided at the end. The DSC is considered to be a unique and versatile procedure for modeling behaviors of engineering materials and interfaces.

  8. An Adaptive Unified Differential Evolution Algorithm for Global Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Qiang, Ji; Mitchell, Chad

    2014-11-03

    In this paper, we propose a new adaptive unified differential evolution algorithm for single-objective global optimization. Instead of the multiple mutation strate- gies proposed in conventional differential evolution algorithms, this algorithm employs a single equation unifying multiple strategies into one expression. It has the virtue of mathematical simplicity and also provides users the flexibility for broader exploration of the space of mutation operators. By making all control parameters in the proposed algorithm self-adaptively evolve during the process of optimization, it frees the application users from the burden of choosing appro- priate control parameters and also improves the performance of the algorithm. In numerical tests using thirteen basic unimodal and multimodal functions, the proposed adaptive unified algorithm shows promising performance in compari- son to several conventional differential evolution algorithms.

  9. Towards a Unified Sentiment Lexicon Based on Graphics Processing Units

    Directory of Open Access Journals (Sweden)

    Liliana Ibeth Barbosa-Santillán

    2014-01-01

    Full Text Available This paper presents an approach to create what we have called a Unified Sentiment Lexicon (USL. This approach aims at aligning, unifying, and expanding the set of sentiment lexicons which are available on the web in order to increase their robustness of coverage. One problem related to the task of the automatic unification of different scores of sentiment lexicons is that there are multiple lexical entries for which the classification of positive, negative, or neutral {P,N,Z} depends on the unit of measurement used in the annotation methodology of the source sentiment lexicon. Our USL approach computes the unified strength of polarity of each lexical entry based on the Pearson correlation coefficient which measures how correlated lexical entries are with a value between 1 and −1, where 1 indicates that the lexical entries are perfectly correlated, 0 indicates no correlation, and −1 means they are perfectly inversely correlated and so is the UnifiedMetrics procedure for CPU and GPU, respectively. Another problem is the high processing time required for computing all the lexical entries in the unification task. Thus, the USL approach computes a subset of lexical entries in each of the 1344 GPU cores and uses parallel processing in order to unify 155802 lexical entries. The results of the analysis conducted using the USL approach show that the USL has 95.430 lexical entries, out of which there are 35.201 considered to be positive, 22.029 negative, and 38.200 neutral. Finally, the runtime was 10 minutes for 95.430 lexical entries; this allows a reduction of the time computing for the UnifiedMetrics by 3 times.

  10. Design of output feedback controller for a unified chaotic system

    Institute of Scientific and Technical Information of China (English)

    Li Wen-Lin; Chen Xiu-Qin; Shen Zhi-Ping

    2008-01-01

    In this paper,the synchronization of a unified chaotic system is investigated by the use of output feedback controllers;a two-input single-output feedback controller and single-input single-output feedback controller are presented to synchronize the unified chaotic system when the states are not all measurable.Compared with the existing results,the controllers designed in this paper have some advantages such as small feedback gain,simple structure and less conservation.Finally,numerical simulations results are provided to demonstrate the validity and effectiveness of the proposed method.

  11. Unifying acute stroke treatment guidelines for a Bayesian belief network.

    Science.gov (United States)

    Love, Alexa; Arnold, Corey W; El-Saden, Suzie; Liebeskind, David S; Andrada, Lewellyn; Saver, Jeffrey; Bui, Alex A T

    2013-01-01

    With the large number of clinical practice guidelines available, there is an increasing need for a comprehensive unified model for acute ischemic stroke treatment to assist in clinical decision making. We present a unified treatment model derived through review of existing clinical practice guidelines, meta-analyses, and clinical trials. Using logic from the treatment model, a Bayesian belief network was defined and fitted to data from our institution's observational quality improvement database for acute stroke patients. The resulting network validates known relationships between variables, treatment decisions and outcomes, and enables the exploration of new correlative relationships not defined in current guidelines.

  12. Unified Model of Purification Units in Hydrogen Networks

    Institute of Scientific and Technical Information of China (English)

    吴思东; 王彧斐; 冯霄

    2014-01-01

    Purification processes are widely used in hydrogen networks of refineries to increase hydrogen reuse. In refineries, hydrogen purification techniques include hydrocarbon, hydrogen sulfide and CO removal units. In addi-tion, light hydrocarbon recovery from the hydrogen source streams can also result in hydrogen purification. In order to simplify the superstructure and mathematical model of hydrogen network integration, the models of different pu-rification processes are unified in this paper, including mass balance and the expressions for hydrogen recovery and impurity removal ratios, which are given for all the purification units in refineries. Based on the proposed unified model, a superstructure of hydrogen networks with purification processes is constructed.

  13. Synchronization of Unified Chaotic System Using Occasional Driving

    Institute of Scientific and Technical Information of China (English)

    Wu Xiao-qun; Lu Jun-an

    2003-01-01

    The synchronization of the unified chaotic systems using occasional driving technique is studied. The relation among interim period T, sampling interval 2ε, feedback gain r and the parameter α of the system is thoroughly investigated. Numerical results show that smaller interim period T and properly larger sampling interval 2ε can accelerate the synchronizing pace. Furthermore, for a unified chaotic system in which a is given, we can achieve satisfying synchronizing results as long as T,ε and r are appropriately chosen. As we adopt the occasional driving method, we greatly reduce the control cost. Therefore with this method we can obtain the expecting goals with little control cost.

  14. Synchronization of Unified Chaotic System Using Occasional Driving

    Institute of Scientific and Technical Information of China (English)

    WuXiao-qun; LuJun-an

    2003-01-01

    The synchronization of the unified chaotic systems using occasional driving technique is studied. The relation among interim period T, sampling interval 2ε, feedback gain r and the parameter α of the system is thoroughly investigated. Numerical results show that smaller interim period T and properly larger sampling interval 2ε can accelerate the synchronizing pace. Furthermore, for a unified chaotic systemin which α is given, we can achieve satisfying synchronizing results as long as T,ε and r are appropriately chosen. As we adopt the occasional driving method, we greatly reduce the control cost. Therefore with this method we can obtain the expeetlng goals with little control cost.

  15. On the dynamics of unified k-essence cosmologies

    CERN Document Server

    De-Santiago, Josue

    2012-01-01

    We analyze the phase space of a particular unified model of dark matter, dark energy, and inflation that we recently studied in [Phys. Rev. D 83, 063502 (2011)] whose Lagrangian is of the form L(X,phi) = F(X) - V(phi). We show that this model possesses a large set of initial conditions consistent with a successful cosmological model in which an inflationary phase is possible, followed by a matter era to end with dark energy domination. In order to understand the success of the model, we study the general features that unified dark matter (UDM) models should comply and then we analyze some particular models and find their constrictions.

  16. The SELEX Measurements in the Unified Picture for Hadron Spectra

    CERN Document Server

    Arkhipov, A A

    2004-01-01

    We give an analysis of the experimental material presented by the SELEX Collaboration to find the true place for the SELEX state $D_{sJ}^+$(2632) in the unified picture for hadron spectra developed early. It is found that the SELEX measurements are excellently incorporated in the unified picture for hadron spectra. Our analysis shows that the measured values for the masses of the SELEX state exactly coincide with the calculated masses of the states living in the corresponding KK towers. We also found quite a natural but rather model dependent explanation of the decay pattern for the SELEX state being dominated by the $D_s^+\\eta$ decay mode.

  17. A Unified Model of All Generalizations from the Jones Polynomial

    Institute of Scientific and Technical Information of China (English)

    QIAN Shang-Wu; GU Zhi-Yu

    2001-01-01

    From the basic properties of skein systems, we build a generalized tangle algebra (GTA). The elements of GTA are four basic tangles. There are three operations, which are connection, splicing and scalar multiplication. From GTA we derive two generalized recursion formulae (GRF) and prove the existence of a generalized skein relation which satisfies GRF. The obtained generalized skein relation epitomizes all generalizations from the Jones polynomial and thus forms a unified model. Two important topological parameters, twisting measure and loop values, appear explicitly in the expressions of the unified model, and this fact greatly simplifies the operations.

  18. Unified Schemes for Radio-loud AGN: Recent Results

    OpenAIRE

    Padovani, Paolo

    1997-01-01

    After briefly summarizing the main tenets of unified schemes of Active Galactic Nuclei, I review some recent results in the field of unification of radio-loud sources, both for the low-luminosity (BL Lacs and Fanaroff-Riley type I radio galaxies) and high-luminosity (radio quasars and Fanaroff-Riley type II radio galaxies) populations.

  19. Unified Field Theory and Principle of Representation Invariance

    CERN Document Server

    Ma, Tian

    2012-01-01

    This is part of a research program to establish a unified field model for interactions in nature. The aim of this article is to postulate a new principle of representation invariance (PRI), to provide a needed mathematical foundation for PRI, and to use PRI to refine the unified field equations of four interactions. Intuitively, PRI amounts to saying that all SU(N) gauge theories should be invariant under transformations of different representations of SU(N). With PRI, we are able to substantially reduce the number of to-be-determined parameters in the unified model to two SU(2) and SU(3) constant vectors $\\{\\alpha^1_\\mu \\}$ and $\\{\\alpha^2_k\\}$, containing 11 parameters, which represent the portions distributed to the gauge potentials by the weak and strong charges. Furthermore, both PRI and PID can be directly applied to individual interactions, leading to a unified theory for dark matter and dark energy, and theories on strong and weak interaction potentials. As a direct application of the strong interacti...

  20. Catastrophe Theory: A Unified Model for Educational Change.

    Science.gov (United States)

    Cryer, Patricia; Elton, Lewis

    1990-01-01

    Catastrophe Theory and Herzberg's theory of motivation at work was used to create a model of change that unifies and extends Lewin's two separate stage and force field models. This new model is used to analyze the behavior of academics as they adapt to the changing university environment. (Author/MLW)

  1. A Unified Approach for Solving Nonlinear Regular Perturbation Problems

    Science.gov (United States)

    Khuri, S. A.

    2008-01-01

    This article describes a simple alternative unified method of solving nonlinear regular perturbation problems. The procedure is based upon the manipulation of Taylor's approximation for the expansion of the nonlinear term in the perturbed equation. An essential feature of this technique is the relative simplicity used and the associated unified…

  2. A vielbein formulation of unified Einstein-Maxwell theory

    CERN Document Server

    Vignolo, Stefano

    2016-01-01

    In the framework of J-bundles a vielbein formulation of unified Einstein-Maxwell theory is proposed. In the resulting scheme, field equations matching the gravitational and electromagnetic fields are derived by constraining a five-dimensional variational principle. No dynamical scalar field is involved.

  3. Unified rotational dynamics of molecular crystals with orientational phase transition

    NARCIS (Netherlands)

    Michel, K.H.; Raedt, H. De

    1976-01-01

    A unified theory for the rotational dynamics of molecular crystals with orientational phase transitions is given. As basic secular variables one takes symmetry adapted functions, which describe the molecular orientations, and the angular momenta of the molecules. Using Mori’s projection operator tec

  4. Reciprocal Symmetric Boltzmann Function and Unified Boson-Fermion Statistics

    OpenAIRE

    2007-01-01

    The differential equation for Boltzmann's function is replaced by the corresponding discrete finite difference equation. The difference equation is, then, symmetrized so that the equation remains invariant when step d is replaced by -d. The solutions of this equation come in Boson-Fermion pairs. Reciprocal symmetric Boltzmann's function, thus, unifies both Bosonic and Fermionic distributions.

  5. When Unified Teacher Pay Scales Meet Differential Alternative Returns

    Science.gov (United States)

    Walsh, Patrick

    2014-01-01

    This paper quantifies the extent to which unified teacher pay scales and differential alternatives produce opportunity costs that are asymmetric in math and verbal skills. Data from the Baccalaureate and Beyond 1997 and 2003 follow-ups are used to estimate a fully parametric, selection-corrected wage equation for nonteachers, which is then used to…

  6. A unifying approach to existence of Nash equilibria

    NARCIS (Netherlands)

    Balder, E.J.

    2001-01-01

    An approach initiated in [4] is shown to unify results about the existence of (i) Nash equilibria in games with at most countably many players, (ii) Cournot-Nash equilibrium distributions for large, anonymous games, and (iii) Nash equilibria (both mixed and pure) for continuum games. A new, central

  7. A unifying theory The universe on a string

    CERN Multimedia

    Greene, Brian

    2006-01-01

    Seventy-five years ago, Albert Einstein completed his unified field theory; but, as had happened before and would happen again, Einstein had to go bak to the drawing board. Much progress have been inspired, with the most recent advances coming from an approach called string theory. (1,5 page)

  8. Unified Technical Concepts. Supplementary Modules S1-S8.

    Science.gov (United States)

    Technical Education Research Center, Waco, TX.

    Prepared for use with thirteen modules (CE 025 468-480) in the Unified Technical Concepts postsecondary physics instructional package, this set of eight support modules is designed to strengthen mathematical and laboratory skills in areas such as units, graphing, logarithms, dimensional analysis, and basic trigonometry. Module titles include…

  9. Finite unified theories and the top quark mass

    Energy Technology Data Exchange (ETDEWEB)

    Mondragon, M. [Heidelberg Univ. (Germany). Inst. fuer Theoretische Physik; Zoupanos, G. [Physics Dept., Nat. Technical Univ., Athens (Greece)

    1995-01-01

    We present results of a study of two phenomenologically interesting SU(5) supersymmetric Grand Unified models, which are finite to all-loops before spontaneous symmetry breaking. The finiteness conditions provide us with relationships among the Yukawa and gauge couplings at the unification point, which in turn predict a heavy top quark mass ( similar 175-190GeV). ((orig.))

  10. Optimization and Sampling for NLP from a Unified Viewpoint

    NARCIS (Netherlands)

    Dymetman, M.; Bouchard, G.; Carter, S.; Bhattacharyya, B.; Ekbal, A.; Saha, S.; Johnson, M.; Molla-Aliod, D.; Dras, M.

    2012-01-01

    The OS* algorithm is a unified approach to exact optimization and sampling, based on incremental refinements of a functional upper bound, which combines ideas of adaptive rejection sampling and of A* optimization search. We first give a detailed description of OS*. We then explain how it can be

  11. Unified State Model theory and application in astrodynamics

    NARCIS (Netherlands)

    Vittaldev, V.; Mooij, E.; Naeije, M.C.

    2012-01-01

    The Unified State Model is a method for expressing orbits using a set of seven elements. The elements consist of a quaternion and three parameters based on the velocity hodograph. A complete derivation of the original model is given in addition to two proposed modifications. Both modifications reduc

  12. Performance Aspects of Orbit Propagation using the Unified State Model

    NARCIS (Netherlands)

    Vittaldev, V.; Mooij, E.; Naeije, M.C.

    2010-01-01

    The Unified State Model is a method for expressing orbits using a set of seven elements. The elements consist of a quaternion and three parameters based on the velocity hodograph. The equations of this model and the background theory necessary to understand them have been shown here. Numerical simul

  13. A UNIFIED APPROACH TO CERTAIN PROBLEMS OF BEST LOCAL APPROXIMATION

    Institute of Scientific and Technical Information of China (English)

    H.H.Cuenya; M.D.Lorenzo; C.N.Rodriguez

    2007-01-01

    In this paper we study best local quasi-rational approximation and best local approximation from finite dimensional subspaces of vectorial functions of several variables.Our approach extends and unifies several problems concerning best local multi-point approximation in different norms.

  14. Unified asymptotic theory for all partial directed coherence forms.

    Science.gov (United States)

    Baccalá, L A; de Brito, C S N; Takahashi, D Y; Sameshima, K

    2013-08-28

    This paper presents a unified mathematical derivation of the asymptotic behaviour of the three main forms of partial directed coherence (PDC). Numerical examples are used to contrast PDC, gPDC (generalized PDC) and iPDC (information PDC) as to meaning and applicability and, more importantly, to show their essential statistical equivalence insofar as connectivity inference is concerned.

  15. Seismic monitoring: a unified system for research and verifications

    Energy Technology Data Exchange (ETDEWEB)

    Thigpen, L.

    1979-02-06

    A system for characterizing either a seismic source or geologic media from observational data was developed. This resulted from an examination of the forward and inverse problems of seismology. The system integrates many seismic monitoring research efforts into a single computational capability. Its main advantage is that it unifies computational and research efforts in seismic monitoring. 173 references, 9 figures, 3 tables.

  16. Towards a unified theory of task-specific motivation

    NARCIS (Netherlands)

    De Brabander, Cees; Martens, Rob

    2014-01-01

    This study aims to integrate the current proliferation of motivation theories in a Unified Model of Task-specific Motivation (UMTM). According to this model readiness for action results from an interaction between four relatively independent types of valences that can be classified as affective or c

  17. 78 FR 18235 - Unified Rule for Loss on Subsidiary Stock

    Science.gov (United States)

    2013-03-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Internal Revenue Service 26 CFR Part 1 Unified Rule for Loss on Subsidiary Stock CFR Correction 0 In Title..., the preferred stock is treated as entitled to a distribution no later than the time the...

  18. On a Unified Theory of Estimation in Linear Models

    Science.gov (United States)

    which depends on the numerical evaluation of a g-inverse of a partitioned matrix. Another is an analogue of least square theory and is called unified... least square (ULS) method. The aim of the paper is to bring out the salient features of these two methods and to point out some interesting features of

  19. Schr"odinger's Unified Field Theory: Physics by Public Relations

    Science.gov (United States)

    Halpern, Paul

    2009-05-01

    We will explore the circumstances surrounding Erwin Schr"odinger's announcement in January 1947 that he had developed a comprehensive unified field theory of gravitation and electromagnetism. We will speculate on Schr"odinger's motivations for the mode and tone of his statements, consider the reaction of the international press within the context of the postwar era, and examine Einstein's response.

  20. THE UNIFIED LEVELLING NETWORK OF SARAWAK AND ITS ADJUSTMENT

    Directory of Open Access Journals (Sweden)

    Z. A. M. Som

    2016-09-01

    Full Text Available The height reference network of Sarawak has seen major improvement in over the past two decades. The most significant improvement was the establishment of extended precise leveling network of which is now able to connect all three major datum points at Pulau Lakei, Original and Bintulu. Datum by following the major accessible routes across Sarawak. This means the leveling network in Sarawak has now been inter-connected and unified. By having such a unified network leads to the possibility of having a common single least squares adjustment been performed for the first time. The least squares adjustment of this unified levelling network was attempted in order to compute the height of all Bench Marks established in the entire levelling network. The adjustment was done by using MoreFix levelling adjustment package developed at FGHT UTM. The computational procedure adopted is linear parametric adjustment by minimum constraint. Since Sarawak has three separate datums therefore three separate adjustments were implemented by utilizing datum at Pulau Lakei, Original Miri and Bintulu Datum respectively. Results of the MoreFix unified adjustment agreed very well with adjustment repeated using Starnet. Further the results were compared with solution given by Jupem and they are in good agreement as well. The difference in height analysed were within 10mm for the case of minimum constraint at Pulau Lakei datum and with much better agreement in the case of Original Miri Datum.

  1. Unifying the Universe the physics of heaven and earth

    CERN Document Server

    Padamsee, Hasan S

    2003-01-01

    Unifying the Universe: The Physics of Heaven and Earth provides a solid background in basic physics. With a humanistic perspective, it shows how science is significant for more than its technological consequences. The book includes clear and well-planned links to the arts and philosophies of relevant historical periods to bring science and the humanities together.

  2. RIEMANNIAN GEOMETRY AND UNIFIED FIELD THEORY IN 6D

    Directory of Open Access Journals (Sweden)

    Trunev A. P.

    2015-01-01

    Full Text Available The article discusses the Riemann's unified field theory and its extension in 6D in general relativity. It is shown that in 6D there are possible movements on two spherical areas in the form of nonlinear waves

  3. Catastrophe Theory: A Unified Model for Educational Change.

    Science.gov (United States)

    Cryer, Patricia; Elton, Lewis

    1990-01-01

    Catastrophe Theory and Herzberg's theory of motivation at work was used to create a model of change that unifies and extends Lewin's two separate stage and force field models. This new model is used to analyze the behavior of academics as they adapt to the changing university environment. (Author/MLW)

  4. Unified Model for Generation Complex Networks with Utility Preferential Attachment

    Institute of Scientific and Technical Information of China (English)

    WU Jian-Jun; GAO Zi-You; SUN Hui-Jun

    2006-01-01

    In this paper, based on the utility preferential attachment, we propose a new unified model to generate different network topologies such as scale-free, small-world and random networks. Moreover, a new network structure named super scale network is found, which has monopoly characteristic in our simulation experiments. Finally, the characteristics ofthis new network are given.

  5. A Unified Mutual Coupling Model for Multiple Antenna Systems

    Institute of Scientific and Technical Information of China (English)

    WU Yu-jiang; NIE Zai-ping

    2006-01-01

    A unified mutual coupling model for multiple antenna communication systems based on moment methods is proposed. This model combines antenna coupling and RF front-end circuit coupling, thus providing a more accurate and complete analysis of the mutual coupling effect on multiple antenna systems.

  6. Unified characteristics line theory of spacial axisymmetric plastic problem

    Institute of Scientific and Technical Information of China (English)

    俞茂宏; 李建春; 张永强

    2001-01-01

    The unified strength theory proposed by Yu in 1991 is extended to spacial axisymmetric problem. A unified spacial axismymmetric characteristics line theory based on the unified strength theory is proposed. This theory takes account of different effects of intermediate principal stress on yielding or failure and the SD effect (tensile-compression strength difference) of materials. Various conventional axisymmetric characteristics line theories, whihc are based on the Haar-von Karman plastic condition, Szczepinski hypothesis, Tresca criterion, von Mises criterion and Mohr-Coulomb theory, are special cases of the new theory. Besides, a series of new spacial axisymmetric characteristics fields for different materials can be introduced. It forms a unified spacial axisymmetric characteristics theory. Two examples are calculated with the new theory, the results are compared with those obtained by the finite element program UEPP and those based on the Mohr-Coulomb strength theory. It is shown that the new theory is reliable and feasible. The economic benefit can be obtained from the engineering application of the new theory.

  7. Modeling associated protein-DNA pattern discovery with unified scores.

    Science.gov (United States)

    Chan, Tak-Ming; Lo, Leung-Yau; Sze-To, Ho-Yin; Leung, Kwong-Sak; Xiao, Xinshu; Wong, Man-Hon

    2013-01-01

    Understanding protein-DNA interactions, specifically transcription factor (TF) and transcription factor binding site (TFBS) bindings, is crucial in deciphering gene regulation. The recent associated TF-TFBS pattern discovery combines one-sided motif discovery on both the TF and the TFBS sides. Using sequences only, it identifies the short protein-DNA binding cores available only in high-resolution 3D structures. The discovered patterns lead to promising subtype and disease analysis applications. While the related studies use either association rule mining or existing TFBS annotations, none has proposed any formal unified (both-sided) model to prioritize the top verifiable associated patterns. We propose the unified scores and develop an effective pipeline for associated TF-TFBS pattern discovery. Our stringent instance-level evaluations show that the patterns with the top unified scores match with the binding cores in 3D structures considerably better than the previous works, where up to 90 percent of the top 20 scored patterns are verified. We also introduce extended verification from literature surveys, where the high unified scores correspond to even higher verification percentage. The top scored patterns are confirmed to match the known WRKY binding cores with no available 3D structures and agree well with the top binding affinities of in vivo experiments.

  8. Unified Approach to Universal Cloning and Phase-Covariant Cloning

    OpenAIRE

    Hu, Jia-Zhong; Yu, Zong-Wen; Wang, Xiang-Bin

    2008-01-01

    We analyze the problem of approximate quantum cloning when the quantum state is between two latitudes on the Bloch's sphere. We present an analytical formula for the optimized 1-to-2 cloning. The formula unifies the universal quantum cloning (UQCM) and the phase covariant quantum cloning.

  9. Approximation analytical solutions for a unified plasma sheath model by double decomposition method

    Institute of Scientific and Technical Information of China (English)

    FangJin-Qing

    1998-01-01

    A unified plasma sheath model and its potential equation are proposed.Any higher-order approximation analytical solutions for the unified plasma sheath potential equation are derived by double decomposition method.

  10. 77 FR 32493 - Approval of Air Quality Implementation Plans; California; San Joaquin Valley Unified Air...

    Science.gov (United States)

    2012-06-01

    ... Unified Air Pollution Control District; Prevention of Significant Deterioration AGENCY: Environmental... submitted for the San Joaquin Valley Unified Air Pollution Control District (District) portion of the... authority to address disproportionate human health or environmental effects with practical, appropriate,...

  11. 76 FR 41745 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

    Science.gov (United States)

    2011-07-15

    ... Air Pollution Control District AGENCY: Environmental Protection Agency (EPA). ACTION: Proposed rule... Valley Unified Air Pollution Control District portion of the California State Implementation Plan (SIP... Valley Unified Air Pollution Control District (SJVUAPCD) Rule 4682, Polystyrene, Polyethylene, and...

  12. 76 FR 68106 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

    Science.gov (United States)

    2011-11-03

    ... Unified Air Pollution Control District AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: EPA is finalizing approval of revisions to the San Joaquin Valley Unified Air Pollution Control... CFR Part 52 Environmental protection, Air pollution control, Incorporation by reference...

  13. 77 FR 66548 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

    Science.gov (United States)

    2012-11-06

    ... Air Pollution Control District AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: EPA is approving revisions to the San Joaquin Valley Unified Air Pollution Control District... State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District's Rule 4352,...

  14. The Moon as a unifying sociological attraction

    Science.gov (United States)

    Barbieri, C.; Pachera, S.; Ciucci, A.

    We propose to develop an economic, fully automated telescope to equip a variety of public and private buildings, such as disco dancings, pubs, resting houses, hospitals, schools etc., optimized to image and project the Moon, both in daylight and nightime. We strongly believe that the wide spread conscience of being part of a common Universe, by imaging the real Moon ( not a series of computer files) and following its changing course, distributed in places where the soul is usually taken in a wave of loneliness, can have a profound effect. In fact, living such an experience of observation in places where people of all ages usually meet, can help them to mix up socially and have fun and acquire new interests and fulfillment. They could confront their doubts, opinions, curiosity. The Moon is the natural choice, being visible even in polluted cities, it comes to the Zenith of a large band on the Earth encompassing each emisphere, it has deeply rooted meanings in all civilizations, and it is therefore the perfect astronomical object towards which humanity should direct its view above the ground. The possibility of the instrument to zoom in and out and to move across the surface of the Moon or to observe in real time the slowly moving line of the terminator, is intended just for the sheer wonder of it. No didactic use is meant to begin with, although interest is sure to be stimulated and may be followed up in many ways. Our object is indeed to make young and older people throughout the world feel our satellite nearer and more familiar in the shapes and names of its features, truly a constant presence in our everyday natural surroundings. When the time will come for human coloniz ation, the Moon could no longer be considered such an extraneous, exotic and faraway new home. The telescope can be built in very large quantities by a variety of firms practically even in underdeveloped countries, easily automated and connected to the world wide web.

  15. 76 FR 68103 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

    Science.gov (United States)

    2011-11-03

    ... Unified Air Pollution Control District AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: EPA is finalizing approval of revisions to the San Joaquin Valley Unified Air Pollution Control... Rulemaking For the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control...

  16. Organizational Structures to Support Oakland Community Schools. Knowledge Brief

    Science.gov (United States)

    John W. Gardner Center for Youth and Their Communities, 2015

    2015-01-01

    This brief is part of a series that shares findings from a research collaboration between the John W. Gardner Center for Youth and Their Communities at Stanford University and Oakland Unified School District (OUSD) focused on understanding implementation of the community school model in the district. This brief highlights findings related to…

  17. Procedures Handbook for Elementary School IMC Clerks. Revised.

    Science.gov (United States)

    Allen, Christine

    This training manual describes and explains the variety of tasks performed by library clerks in the Riverside (California) Unified School District's elementary school instructional media centers (IMCs). It is noted that the job responsibilities of these clerks fall into four areas with specific duties relating to each: maintenance of the…

  18. Pre-School Education in Morocco and Algeria

    Science.gov (United States)

    Bouzoubaa, Khadija; Benghabrit-Remaoun, Nouria

    2004-01-01

    This article is an analysis of the current state of early childhood care in the Maghreb, in particular in Morocco and Algeria, where the pre-schooling rate for 5-year-olds is on the increase. Extending pre-school infrastructures and the need to create unified curricula have been among the most urgent questions to be tackled over the last decade in…

  19. An assessment of Evans' unified field theory I

    CERN Document Server

    Hehl, F W

    2007-01-01

    Evans developed a classical unified field theory of gravitation and electromagnetism on the background of a spacetime obeying a Riemann-Cartan geometry. This geometry can be characterized by an orthonormal coframe theta and a (metric compatible) Lorentz connection Gamma. These two potentials yield the field strengths torsion T and curvature R. Evans tried to infuse electromagnetic properties into this geometrical framework by putting the coframe theta to be proportional to four extended electromagnetic potentials A; these are assumed to encompass the conventional Maxwellian potential in a suitable limit. The viable Einstein-Cartan(-Sciama-Kibble) theory of gravity was adopted by Evans to describe the gravitational sector of his theory. Including also the results of an accompanying paper by Obukhov and the author, we show that Evans' ansatz for electromagnetism is untenable beyond repair both from a geometrical as well as from a physical point of view. As a consequence, his unified theory is obsolete.

  20. A Unified Theory of Information,Knowledge and Intelligence

    Institute of Scientific and Technical Information of China (English)

    ZHONGYixin

    2003-01-01

    Information, knowledge and intelligence have long been widely regarded as the most valuable wealth to mankind and there have been great number of papersdis cussing the issues on each of the three. There has also been strong belief on the point of view that there must be a deep linkage existing among information, knowledge and intelligence. On the other hand, however, there has not yet appeared a thoroughly unified theory of information,knowledge and intelligence till the present time. This is mainly because of the lack of a systemic theory of knowl-edge that in fact is a channel through which information may finally be refined into intelligence. An attempt is thus made in the paper to present a foundation and a frame-work of knowledge Theory that should be able to bridge the information theory on one hand and the intelligence theory on the other hand, thus forming a unified theory of information, knowledge, and intelligence.

  1. Partial and unified crossed products are weak crossed products

    CERN Document Server

    Vilaboa, J M Fernández; Raposo, A B Rodríguez

    2011-01-01

    In [J.M. Fern\\'andez Vilaboa, R. Gonz\\'alez Rodr\\'iguez and A.B. Rodr\\'iguez Raposo: Preunits and weak crossed products. J. of Pure Appl. Algebra 213, 2244-2261 (2009)] the notion of a weak crossed product of an algebra by an object, both living in a monoidal category was presented. Unified crossed products defined in [A. Agore, G. Militaru: Extending structures II: The quantum version. arXiv:1011.2174v3 (2011)] and partial crossed products defined in [M. Muniz S. Alves, E. Batista, M. Dokuchaev, A. Paques: Twisted partial actions of Hopf algebras. preprint (2011)] are crossed product structures defined for a Hopf algebra and another object. In this paper we prove that unified crossed products and partial crossed products are particular instances of weak crossed products.

  2. Unified Model in Identity Subspace for Face Recognition

    Institute of Scientific and Technical Information of China (English)

    Pin Liao; Li Shen; Yi-Qiang Chen; Shu-Chang Liu

    2004-01-01

    Human faces have two important characteristics: (1) They are similar objects and the specific variations of each face are similar to each other; (2) They are nearly bilateral symmetric. Exploiting the two important properties, we build a unified model in identity subspace (UMIS) as a novel technique for face recognition from only one example image per person. An identity subspace spanned by bilateral symmetric bases, which compactly encodes identity information, is presented. The unified model, trained on an obtained training set with multiple samples per class from a known people group A, can be generalized well to facial images of unknown individuals,and can be used to recognize facial images from an unknown people group B with only one sample per subject.Extensive experimental results on two public databases (the Yale database and the Bern database) and our own database (the ICT-JDL database) demonstrate that the UMIS approach is significantly effective and robust for face recognition.

  3. Unified relativistic physics from a standing wave particle model

    CERN Document Server

    Vera, R A

    1995-01-01

    An extremely simple and unified base for physics comes out by starting all over from a single postulate on the common nature of matter and stationary forms of radiation quanta. Basic relativistic, gravitational (G) and quantum mechanical properties of a standing wave particle model have been derived. This has been done from just dual properties of radiation's and strictly homogeneous relationships for nonlocal cases in G fields. This way reduces the number of independent variables and puts into relief (and avoid) important inhomogeneity errors of some G theories. It unifies and accounts for basic principles and postulates physics. The results for gravity depend on linear radiation properties but not on arbitrary field relations. They agree with the conventional tests. However they have some fundamental differences with current G theories. The particle model, at a difference of the conventional theories, also fixes well-defined cosmological and astrophysical models that are different from the rather convention...

  4. A unified model explains commonness and rarity on coral reefs.

    Science.gov (United States)

    Connolly, Sean R; Hughes, Terry P; Bellwood, David R

    2017-04-01

    Abundance patterns in ecological communities have important implications for biodiversity maintenance and ecosystem functioning. However, ecological theory has been largely unsuccessful at capturing multiple macroecological abundance patterns simultaneously. Here, we propose a parsimonious model that unifies widespread ecological relationships involving local aggregation, species-abundance distributions, and species associations, and we test this model against the metacommunity structure of reef-building corals and coral reef fishes across the western and central Pacific. For both corals and fishes, the unified model simultaneously captures extremely well local species-abundance distributions, interspecific variation in the strength of spatial aggregation, patterns of community similarity, species accumulation, and regional species richness, performing far better than alternative models also examined here and in previous work on coral reefs. Our approach contributes to the development of synthetic theory for large-scale patterns of community structure in nature, and to addressing ongoing challenges in biodiversity conservation at macroecological scales.

  5. Constructal Law and the Unifying Principle of Design

    CERN Document Server

    Lorente, Sylvie; Bejan, Adrian

    2013-01-01

    Design happens everywhere, whether in animate objects (e.g., dendritic lung structures, bacterial colonies, and corals), inanimate patterns (river basins, beach slope, and dendritic crystals), social dynamics (pedestrian traffic flows), or engineered systems (heat dissipation in electronic circuitry). This “design in nature” often takes on remarkably similar patterns, which can be explained under one unifying Constructal Law. This book explores the unifying power of the Constructal Law and its applications in all domains of design generation and evolution, ranging from biology and geophysics to globalization, energy, sustainability, and security.  The Constructal Law accounts for the universal tendency of flow systems to morph into evolving configurations that provide greater and easier access over time. The Constructal Law resolves the many and contradictory ad hoc statements of “optimality”, end design, and destiny in nature, such as minimum and maximum entropy production and minimum and maximum fl...

  6. Unified Power Quality Conditioner for voltage and current compensation

    Directory of Open Access Journals (Sweden)

    P.Annapandi

    2012-07-01

    Full Text Available This paper deals with a Unified Power Quality Conditioner (UPQC for load balancing, power factorcorrection, voltage regulation, voltage and current harmonics mitigation, mitigation of voltage sag, swelland voltage dip in a three-phase three-wire distribution system for different combinations of linear and nonlinear loads.The unified power quality conditioner (UPQC is a combination of back to back connected shunt and series active power filters (APFs to a common DC link voltage, which compensates voltage and current based distortions, independently.Using instantaneous active and reactive Power theory ,harmonic detection, reactive power compensation, voltage sag and swell have been simulated and the results are analyzed. The operation and capability of the proposed system was analyzed through simulations with MATLAB / SIMULINK.

  7. Unit Invariance as a Unifying Principle of Physics

    CERN Document Server

    Shaukat, Abrar

    2010-01-01

    A basic principle of physics is the freedom to locally choose any unit system when describing physical quantities. Its implementation amounts to treating Weyl invariance as a fundamental symmetry of all physical theories. In this thesis, we study the consequences of this "unit invariance" principle and find that it is a unifying one. Unit invariance is achieved by introducing a gauge field called the scale, designed to measure how unit systems vary from point to point. In fact, by a uniform and simple Weyl invariant coupling of scale and matter fields, we unify massless, massive, and partially massless excitations. As a consequence, masses now dictate the response of physical quantities to changes of scale. This response is calibrated by certain "tractor Weyl weights". Reality of these weights yield Breitenlohner-Freedman stability bounds in anti de Sitter spaces. Another valuable outcome of our approach is a general mechanism for constructing conformally invariant theories. In particular, we provide direct d...

  8. A Unifying Framework for Local Throughput in Wireless Networks

    CERN Document Server

    Pinto, Pedro C

    2010-01-01

    With the increased competition for the electromagnetic spectrum, it is important to characterize the impact of interference in the performance of a wireless network, which is traditionally measured by its throughput. This paper presents a unifying framework for characterizing the local throughput in wireless networks. We first analyze the throughput of a probe link from a connectivity perspective, in which a packet is successfully received if it does not collide with other packets from nodes within its reach (called the audible interferers). We then characterize the throughput from a signal-to-interference-plus-noise ratio (SINR) perspective, in which a packet is successfully received if the SINR exceeds some threshold, considering the interference from all emitting nodes in the network. Our main contribution is to generalize and unify various results scattered throughout the literature. In particular, the proposed framework encompasses arbitrary wireless propagation effects (e.g, Nakagami-m fading, Rician fa...

  9. Unified EEG terminology and criteria for nonconvulsive status epilepticus.

    Science.gov (United States)

    Beniczky, Sándor; Hirsch, Lawrence J; Kaplan, Peter W; Pressler, Ronit; Bauer, Gerhard; Aurlien, Harald; Brøgger, Jan C; Trinka, Eugen

    2013-09-01

    The diagnosis of nonconvulsive status epilepticus (NCSE) relies largely on electroencephalography (EEG) findings. The lack of a unified EEG terminology, and of evidence-based EEG criteria, leads to varying criteria for and ability to diagnose NCSE. We propose a unified terminology and classification system for NCSE, using, as a template, the Standardised Computer-based Organised Reporting of EEG (SCORE). This approach integrates the terminology recently proposed for the rhythmic and periodic patterns in critically ill patients, the electroclinical classification of NCSE (type of NCSE) and the context for the pathologic conditions and age-related epilepsy syndromes. We propose flexible EEG criteria that employ the SCORE system to assemble a database for determining evidence-based EEG criteria for NCSE.

  10. Modeling Enterprise Authorization: A Unified Metamodel and Initial Validation

    Directory of Open Access Journals (Sweden)

    Matus Korman

    2016-07-01

    Full Text Available Authorization and its enforcement, access control, have stood at the beginning of the art and science of information security, and remain being crucial pillar of security in the information technology (IT and enterprises operations. Dozens of different models of access control have been proposed. Although Enterprise Architecture as the discipline strives to support the management of IT, support for modeling access policies in enterprises is often lacking, both in terms of supporting the variety of individual models of access control nowadays used, and in terms of providing a unified ontology capable of flexibly expressing access policies for all or the most of the models. This study summarizes a number of existing models of access control, proposes a unified metamodel mapped to ArchiMate, and illustrates its use on a selection of example scenarios and two business cases.

  11. Unified dark fluid in Brans-Dicke theory

    Energy Technology Data Exchange (ETDEWEB)

    Tripathy, Sunil K. [Indira Gandhi Institute of Technology, Department of Physics, Dhenkanal, Odisha (India); Behera, Dipanjali [Government College of Engineering, Department of Physics, Kalahandi, Odisha (India); Mishra, Bivudutta [Birla Institute of Technology and Science-Pilani, Department of Mathematics, Hyderabad (India)

    2015-04-01

    Anisotropic dark energy cosmological models are constructed in the frame work of generalised Brans-Dicke theory with a self-interacting potential. A unified dark fluid characterised by a linear equation of state is considered as the source of dark energy. The shear scalar is considered to be proportional to the expansion scalar simulating an anisotropic relationship among the directional expansion rates. The dynamics of the universe in the presence of a unified dark fluid in anisotropic background have been discussed. The presence of an evolving scalar field makes it possible to get an accelerating phase of expansion even for a linear relationship among the directional Hubble rates. It is found that the anisotropy in expansion rates does not affect the scalar field, the self-interacting potential, but it controls the non-evolving part of the Brans-Dicke parameter. (orig.)

  12. A simplification of the unified gas kinetic scheme

    CERN Document Server

    Chen, Songze; Xu, Kun

    2016-01-01

    Unified gas kinetic scheme (UGKS) is an asymptotic preserving scheme for the kinetic equations. It is superior for transition flow simulations, and has been validated in the past years. However, compared to the well known discrete ordinate method (DOM) which is a classical numerical method solving the kinetic equations, the UGKS needs more computational resources. In this study, we propose a simplification of the unified gas kinetic scheme. It allows almost identical numerical cost as the DOM, but predicts numerical results as accurate as the UGKS. Based on the observation that the equilibrium part of the UGKS fluxes can be evaluated analytically, the equilibrium part in the UGKS flux is not necessary to be discretized in velocity space. In the simplified scheme, the numerical flux for the velocity distribution function and the numerical flux for the macroscopic conservative quantities are evaluated separately. The simplification is equivalent to a flux hybridization of the gas kinetic scheme for the Navier-S...

  13. Unifying inflation with late-time acceleration in BIonic system

    CERN Document Server

    Sepehri, Alireza; Setare, Mohammad Reza; Pradhan, Anirudh; Capozziello, Salvatore; Sardar, Iftikar Hossain

    2015-01-01

    In this research, we propose a new model that allows to unify inflation, deceleration and acceleration phases of expansion history in BIonic system. In this model, in the beginning, there have been $k$ black fundamental strings that transited to the BIon configuration at a corresponding point. At this point, two universe brane and universe antibrane have been created, interacted with each other via one wormhole and inflated. With decreasing temperature, the energy of this wormhole flowed into universe branes and lead to inflation. After a short time, wormhole died, inflation ended and deceleration epoch started. With approaching two universe brane and antibrane together, tachyon was born, grew and caused creation of one new wormhole. At this time, two universe brane and antibrane connected again and late-time acceleration era of the universe began. We compare our model with previous unified phantom model and observational data and obtain some cosmological parameters like temperature in terms of time. We also ...

  14. Research on a didtributed simulation based on unified interface

    Institute of Scientific and Technical Information of China (English)

    孙知信; 王汝传; 王绍棣; 张钦

    2004-01-01

    With the scale of simulation system increasing rapidly, the distributed interactive simulation (DIS) faces the problem fo system scalability. One of main factors, which influence the DIS scalability, is that the lacks of standard defining interface methods, as the number of the system modules increased. This paper presents a method of defining an unified interface among different models. Then a DIS development platform based on it is established after thorough studies of the reasons that cause the DIS scalability problems. Finally we demonstrate the method by realization of an experiment DIS system in LAN environment. It validates that a practical system development can be carried out rapidly and efectively on this DIS development plaform. The experimental results show that the unified interface has general purpose for the design and implementation of DIS systems.

  15. Research and Design in Unified Coding Architecture for Smart Grids

    Directory of Open Access Journals (Sweden)

    Gang Han

    2013-09-01

    Full Text Available Standardized and sharing information platform is the foundation of the Smart Grids. In order to improve the dispatching center information integration of the power grids and achieve efficient data exchange, sharing and interoperability, a unified coding architecture is proposed. The architecture includes coding management layer, coding generation layer, information models layer and application system layer. Hierarchical design makes the whole coding architecture to adapt to different application environments, different interfaces, loosely coupled requirements, which can realize the integration model management function of the power grids. The life cycle and evaluation method of survival of unified coding architecture is proposed. It can ensure the stability and availability of the coding architecture. Finally, the development direction of coding technology of the Smart Grids in future is prospected.

  16. New Constraints on the Unified Model of Seyfert Galaxies

    Science.gov (United States)

    Maiolino, R.; Ruiz, M.; Rieke, G. H.; Keller, L. D.

    1995-06-01

    We present new 10 microns (N-band) photometry for 70 Seyfert galaxies, 43 of them previously unobserved. These observations, together with those collected from the literature, complete the 10 microns photometry for the CfA Sy galaxies and cover 80% of the Sy found in the RSA and 70% of the Sy in the IRAS 12 microns sample. From this data set, we find that Sy not showing any evidence for broad lines are systematically weaker in 10 microns nuclear emission than Sy nuclei having broad lines. This result may indicate the existence of a group of very low-luminosity Sy2 galaxies that do not have Sy1 counterparts in equal numbers, contrary to the strict unified theory. Alternately, the result can be reconciled with unified theories if a specific type of geometry is assumed for the circumnuclear obscuring material. By comparing the 10 microns ground-based observations with the IRAS 12 microns fluxes, we also study the properties of the extended mid-IR emission, i.e., the star forming activity of the host galaxy of the Sy nucleus. We find Sy2 to lie preferentially in galaxies experiencing enhanced star-forming activity, while Sy1 lie in normal or quiescent galaxies. This result appears to be inconsistent with the strict unified model, since the host galaxy properties should be independent of the orientation of a circumnuclear torus and therefore should be independent of nuclear type. Our finding could be explained by adding to the unified model a link between star-forming activity and the amount of obscuring material collected in the circumnuclear region.

  17. Weyl, Majorana and Dirac fields from a unified perspective

    CERN Document Server

    Aste, Andreas

    2016-01-01

    A self-contained derivation of the formalism describing Weyl, Majorana and Dirac fields from a unified perspective is given based on a concise description of the representation theory of the proper orthochronous Lorentz group. Lagrangian methods play no role in the present exposition, which covers several fundamental aspects of relativistic field theory which are commonly not included in introductory courses treating fermionic fields via the Dirac equation in the first place.

  18. Maxwell and Dirac theories as an already unified theory

    OpenAIRE

    1995-01-01

    In this paper we formulate Maxwell and Dirac theories as an already unified theory (in the sense of Misner and Wheeler). We introduce Dirac spinors as "Dirac square root" of the Faraday bivector, and use this in order to find a spinorial representation of Maxwell equations. Then we show that under certain circunstances this spinor equation reduces to an equation formally identical to Dirac equation. Finally we discuss certain conditions under which this equation can be really interpreted as D...

  19. A Unified Access Model for Interconnecting Heterogeneous Wireless Networks

    Science.gov (United States)

    2015-05-01

    with each other via a central controller. The 2 access technologies used were 802.11 ( WiFi ) and a Carrier-Sense Multiple Access (CSMA) protocol ...wireless subnets could communicate with each other. 3. Results and Discussion Using the 3-VM LTE/ WiFi configuration, we placed a User Datagram Protocol ...control plane protocols . A network model that can abstract disparate MAC layers in heterogeneous networks and interconnect them using a unified and

  20. Dark radiation from a unified dark fluid model

    CERN Document Server

    Geng, Chao-Qiang; Zhang, Xin

    2014-01-01

    We present a unified dark fluid model to describe the possible evolutionary behavior of $\\Delta N_\\mathrm{eff}$ in dark radiation. This model can be viewed as an interacting model for the dark sectors, in which dark matter interacts with dark radiation. We show that the evolution of $\\Delta N_\\mathrm{eff}$ can be nicely explained without some drawbacks, such as the blowup of $\\Delta N_\\mathrm{eff}$ at the late time and the interaction term at the early time.

  1. A unified theory of plastic buckling of columns and plates

    Science.gov (United States)

    Stowell, Elbridge Z

    1948-01-01

    On the basis of modern plasticity considerations, a unified theory of plastic buckling applicable to both columns and plates has been developed. For uniform compression, the theory shows that long columns which bend without appreciable twisting require the tangent modulus and that long flanges which twist without appreciable bending require the secant modulus. Structures that both bend and twist when they buckle require a modulus which is a combination of the secant modulus and the tangent modulus. (author)

  2. Synchronization in a unified fractional-order chaotic system

    Institute of Scientific and Technical Information of China (English)

    Wu Zheng-Mao; Xie Jian-Ying

    2007-01-01

    In this paper, the synchronization in a unified fractional-order chaotic system is investigated by two methods. One is the frequency-domain method that is analysed by using the Laplace transform theory. The other is the time-domain method that is analysed by using the Lyapunov stability theory. Finally, the numerical simulations are used-to illustrate the effectiveness of the proposed synchronization methods.

  3. State feedback design for singularly perturbed system using unified approach

    Institute of Scientific and Technical Information of China (English)

    Chenxiao CAI; Yun ZOU; Duanjin ZHANG

    2004-01-01

    The state feedback design for singularly perturbed systems described in Delta operator is considered.The composite state feedback controller for slow and fast subsystems is designed by using the direct method.The obtained results can bring previous conclusions of continuous and discrete time systems into the unified Delta framework.A simulation example is presented to demonstrate the validity and efficiency of the design.

  4. Estimating High-Frequency Based (Co-) Variances: A Unified Approach

    DEFF Research Database (Denmark)

    Voev, Valeri; Nolte, Ingmar

    We propose a unified framework for estimating integrated variances and covariances based on simple OLS regressions, allowing for a general market microstructure noise specification. We show that our estimators can outperform, in terms of the root mean squared error criterion, the most recent...... frequency derived in Bandi & Russell (2005a) and Bandi & Russell (2005b). For a realistic trading scenario, the efficiency gains resulting from our approach are in the range of 35% to 50%....

  5. Post-Unified Korean Foreign Policy Options: Regional Implications

    Science.gov (United States)

    2002-09-01

    Korean War, the U.S. security policy toward Korea has been instrumental in promoting peace and stability on the peninsula. The strong defense alliance...request the removal of United States troops from the Korean peninsula and the nullification of the United States-South Korea Mutual Defense Treaty...security alliance. However, after the elimination of the North Korean threat, a unified Korea will be able to redefine its foreign policy options

  6. Weyl, Majorana and Dirac Fields from a Unified Perspective

    Directory of Open Access Journals (Sweden)

    Andreas Aste

    2016-08-01

    Full Text Available A self-contained derivation of the formalism describing Weyl, Majorana and Dirac fields from a unified perspective is given based on a concise description of the representation theory of the proper orthochronous Lorentz group. Lagrangian methods play no role in the present exposition, which covers several fundamental aspects of relativistic field theory, which are commonly not included in introductory courses when treating fermionic fields via the Dirac equation in the first place.

  7. Probing flavor structure in unified theory with scalar spectroscopy

    CERN Document Server

    Inoue, K; Yoshioka, K; Inoue, Kenzo; Kojima, Kentaro; Yoshioka, Koichi

    2007-01-01

    The flavor structure in unified theory is probed with superparticle mass spectrum observed in future particle experiments. A key ingredient is the generation dependence of scalar mass non-degeneracy. The observed non-degeneracy in low-energy regime is shown to provide a direct imprint of flavor structure in high-energy fundamental theory. The implication from flavor-violating rare process is also discussed.

  8. A unified cell biological perspective on axon-myelin injury

    OpenAIRE

    Simons, Mikael; Misgeld, Thomas; Kerschensteiner, Martin

    2014-01-01

    Demyelination and axon loss are pathological hallmarks of the neuroinflammatory disorder multiple sclerosis (MS). Although we have an increasingly detailed understanding of how immune cells can damage axons and myelin individually, we lack a unified view of how the axon–myelin unit as a whole is affected by immune-mediated attack. In this review, we propose that as a result of the tight cell biological interconnection of axons and myelin, damage to either can spread, which might convert a loc...

  9. A Unified Pseudospectral Framework for Nonlinear Controller and Observer Design

    OpenAIRE

    Gong, Qi; Ross, I. Michael; Kang,Wei

    2007-01-01

    Proceedings of the 2007 American Control Conference Marriott Marquis Hotel at Times Square New York City, USA, July 11-13, 2007 As a result of significant progress in pseudospectral methods for real-time dynamic optimization, it has become apparent in recent years that it is possible to present a unified framework for both controller and observer design. In this paper, we present such an approach for nonlinear systems. The method can be applied to a wide variety of nonlinear systems....

  10. Skinner-Rusk unified formalism for higher-order systems

    Science.gov (United States)

    Prieto-Martínez, Pedro Daniel; Román-Roy, Narciso

    2012-07-01

    The Lagrangian-Hamiltonian unified formalism of R. Skinner and R. Rusk was originally stated for autonomous dynamical systems in classical mechanics. It has been generalized for non-autonomous first-order mechanical systems, first-order and higher-order field theories, and higher-order autonomous systems. In this work we present a generalization of this formalism for higher-order non-autonomous mechanical systems.

  11. Unified Communications: Simplifying DoD Communication Methods

    Science.gov (United States)

    2013-04-18

    result of a DDOS attack could shut down IP services for any organization. According to J. Dawkins , CEO and founder of True Digital Security, DDOS...Applications 4, no. 4 (2012): 143. 21 J. Dawkins , G. Manes, and M. Papa, A Framework for Unified Network Security Management: Identifying and Tracking...34 IEEE Network 17, no. 5 (2003): 40-46. Clinger-Cohen Act. Public Law 104-106 (February 10, 1996). Dawkins , J., K. Clark, G. Manes, and M. Papa. "A

  12. Unified description of dense matter in neutron stars and magnetars

    CERN Document Server

    Chamel, N; Mihailov, L M; Velchev, Ch J; Stoyanov, Zh K; Mutafchieva, Y D; Ivanovich, M D; Fantina, A F; Pearson, J M; Goriely, S

    2013-01-01

    We have recently developed a set of equations of state based on the nuclear energy density functional theory providing a unified description of the different regions constituting the interior of neutron stars and magnetars. The nuclear functionals, which were constructed from generalized Skyrme effective nucleon-nucleon interactions, yield not only an excellent fit to essentially all experimental atomic mass data but were also constrained to reproduce the neutron-matter equation of state as obtained from realistic many-body calculations.

  13. Dynamics of Inductive Inference in a Unified Framework

    OpenAIRE

    Gilboa, Itzhak; Samuelson, Larry; Schmeidler, David

    2012-01-01

    We present a model of inductive inference that includes, as special cases, Bayesian reasoning, case-based reasoning, and rule-based reasoning. This unified framework allows us to examine, positively or normatively, how the various modes of inductive inference can be combined and how their relative weights change endogenously. We establish conditions under which an agent who does not know the structure of the data generating process will decrease, over the course of her reasoning, the weight o...

  14. A unified approach to mapping and clustering of bibliometric networks

    OpenAIRE

    Waltman, L.R.; Eck, van, H.N.; Noyons, E.C.M.

    2010-01-01

    In the analysis of bibliometric networks, researchers often use mapping and clustering techniques in a combined fashion. Typically, however, mapping and clustering techniques that are used together rely on very different ideas and assumptions. We propose a unified approach to mapping and clustering of bibliometric networks. We show that the VOS mapping technique and a weighted and parameterized variant of modularity-based clustering can both be derived from the same underlying principle. We i...

  15. Coordination in Disaster Management and Response: A Unified Approach

    Science.gov (United States)

    2007-05-14

    Unified Aproach 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT...Cormen, T.H., Leiserson, C.E., Rivest, R.L., Stein, C.: Introduction to Algorithms. 2nd edn. MIT Press (2001) 6. Kuhn, H.W.: The hungarian method for the

  16. A unified approach to infinite-dimensional integration

    Science.gov (United States)

    Albeverio, S.; Mazzucchi, S.

    2016-04-01

    An approach to infinite-dimensional integration which unifies the case of oscillatory integrals and the case of probabilistic type integrals is presented. It provides a truly infinite-dimensional construction of integrals as linear functionals, as much as possible independent of the underlying topological and measure theoretical structure. Various applications are given, including, next to Feynman path integrals, Schrödinger and diffusion equations, as well as higher order hyperbolic and parabolic equations.

  17. Chassidic Teachings and Modern Psychology: Toward a More Unified Approach.

    Science.gov (United States)

    Turner, Akiva

    2016-06-01

    This article describes how many modern psychological constructs and theories exist in older as well as newer Chassidic and Jewish teachings, particularly those of Chabad Lubavitch. This exploration points toward a potential benefit for a unification of psychology and Chassidic teachings. Psychological theories and constructs explored are Freudian psychoanalysis, cognitive dissonance, cognitive restructuring/reframing, self-efficacy/planned behavior, and logotherapy/existentialism. The article then concludes with a discussion of possible implications of moving toward a unified approach for clinical practitioners.

  18. A Programmable Controller for Unified Management of Virtualized Network Infrastructures

    OpenAIRE

    Yassin, Mohamad; GUILLOUARD, Karine; Ouzzif, Meryem; Picard, Roland; Aluze, Denis

    2017-01-01

    International audience; We are currently witnessing an evolution towards network virtualization and Software Defined Networking (SDN) paradigm. SDN permits the decoupling of the control and data planes of traditional networks, and offers flexible and programmable networks. Besides, the need for dynamic provisioning and composition of networking services leads to the deployment of software components on virtualized network infrastructures. In this paper, we propose a unified management of netw...

  19. Unified Stochastic Geometry Model for MIMO Cellular Networks with Retransmissions

    KAUST Repository

    Afify, Laila H.

    2016-10-11

    This paper presents a unified mathematical paradigm, based on stochastic geometry, for downlink cellular networks with multiple-input-multiple-output (MIMO) base stations (BSs). The developed paradigm accounts for signal retransmission upon decoding errors, in which the temporal correlation among the signal-to-interference-plus-noise-ratio (SINR) of the original and retransmitted signals is captured. In addition to modeling the effect of retransmission on the network performance, the developed mathematical model presents twofold analysis unification for MIMO cellular networks literature. First, it integrates the tangible decoding error probability and the abstracted (i.e., modulation scheme and receiver type agnostic) outage probability analysis, which are largely disjoint in the literature. Second, it unifies the analysis for different MIMO configurations. The unified MIMO analysis is achieved by abstracting unnecessary information conveyed within the interfering signals by Gaussian signaling approximation along with an equivalent SISO representation for the per-data stream SINR in MIMO cellular networks. We show that the proposed unification simplifies the analysis without sacrificing the model accuracy. To this end, we discuss the diversity-multiplexing tradeoff imposed by different MIMO schemes and shed light on the diversity loss due to the temporal correlation among the SINRs of the original and retransmitted signals. Finally, several design insights are highlighted.

  20. The performance of FLake in the Met Office Unified Model

    Directory of Open Access Journals (Sweden)

    Gabriel Gerard Rooney

    2013-12-01

    Full Text Available We present results from the coupling of FLake to the Met Office Unified Model (MetUM. The coupling and initialisation are first described, and the results of testing the coupled model in local and global model configurations are presented. These show that FLake has a small statistical impact on screen temperature, but has the potential to modify the weather in the vicinity of areas of significant inland water. Examination of FLake lake ice has revealed that the behaviour of lakes in the coupled model is unrealistic in some areas of significant sub-grid orography. Tests of various modifications to ameliorate this behaviour are presented. The results indicate which of the possible model changes best improve the annual cycle of lake ice. As FLake has been developed and tuned entirely outside the Unified Model system, these results can be interpreted as a useful objective measure of the performance of the Unified Model in terms of its near-surface characteristics.

  1. Creation and Maintenance of a Unified Astronomy Thesaurus

    Science.gov (United States)

    Gray, Norman; Erdmann, C.; Accomazzi, A.; Soles, J.; McCann, G.; Cassar, M.; Biemesderfer, C.

    2013-01-01

    We describe a collaborative effort to update and unify the various vocabularies currently in use in Astronomy into a single thesaurus that can be further developed and updated through broad community participation. The Unified Astronomy Thesaurus (UAT) will be an open, interoperable and community-supported thesaurus which unifies the existing divergent and isolated Astronomy & Astrophysics thesauri into a single high-quality, freely-available open thesaurus formalizing astronomical concepts and their inter-relationships. The UAT builds upon the existing IAU Thesaurus with major contributions from the Astronomy portions of the thesauri developed by the Institute of Physics Publishing and the American Institute of Physics. While the AAS has assumed formal ownership of the UAT, the work will be available under a Creative Commons License, ensuring its widest use while protecting the intellectual property of the contributors. We envision that development and maintenance will be stewarded by a broad group of parties having a direct stake in it. This includes professional associations (IVOA, IAU), learned societies (AAS, RAS), publishers (IOP, AIP), librarians and other curators working for major astronomy institutes and data archives. While the impetus behind the creation of a single thesaurus has been the wish to support semantic enrichment of the literature, we expect that use of the UAT (along with other vocabularies and ontologies currently being developed) will be much broader and will have a greater impact on discovery of both literatue and data products.

  2. A Cartesian grid-based unified gas kinetic scheme

    Science.gov (United States)

    Chen, Songze; Xu, Kun

    2014-12-01

    A Cartesian grid-based unified gas kinetic scheme is developed. In this approach, any oriented boundary in a Cartesian grid is represented by many directional boundary points. The numerical flux is evaluated on each boundary point. Then, a boundary flux interpolation method (BFIM) is constructed to distribute the boundary effect to the flow evolution on regular Cartesian grid points. The BFIM provides a general strategy to implement any kind of boundary condition on Cartesian grid. The newly developed technique is implemented in the unified gas kinetic scheme, where the scheme is reformulated into a finite difference format. Several typical test cases are simulated with different geometries. For example, the thermophoresis phenomenon for a plate with infinitesimal thickness immersed in a rarefied flow environment is calculated under different orientations on the same Cartesian grid. These computational results validate the BFIM in the unified scheme for the capturing of different thermal boundary conditions. The BFIM can be extended to the moving boundary problems as well.

  3. High School Teachers' Perspectives on the English Language Arts Common Core State Standards: An Exploratory Study

    Science.gov (United States)

    Ajayi, Lasisi

    2016-01-01

    This was an exploratory study that examined high school teachers' perspectives about their early experiences with the English language arts Common Core State Standards. The sources of data for the study included a survey and structured interviews. Twenty-three high school ELA teachers from one unified school district in Southern California…

  4. Do Schools Owe a Special Duty of Care to "Special-Needs" Students?

    Science.gov (United States)

    Fossey, Richard; Russo, Charles J.

    2009-01-01

    Schools officials owe a duty of care to all the students in their custody. An emerging, but not unanimous, judicial consensus seems to agree that school board officials have a greater legal duty when supervising students with disabilities. A case on this important issue arose in "Jennifer C. v. Los Angeles Unified School District"…

  5. Sanger法检测分析非小细胞肺癌患者组织EGFR%Sanger method for detecting tissue EGFR in patients with non-small cell lung cancer

    Institute of Scientific and Technical Information of China (English)

    王金龙; 李宝锋; 罗凯

    2011-01-01

    patiens with EGFB mutation.Conclusions Sanger method for detecting gene mutations in NSCLC can provide technical support for the targeted therapy.

  6. A new unified theory of electromagnetic and gravitational interactions

    Science.gov (United States)

    Li, Li-Xin

    2016-12-01

    In this paper we present a new unified theory of electromagnetic and gravitational interactions. By considering a four-dimensional spacetime as a hypersurface embedded in a five-dimensional bulk spacetime, we derive the complete set of field equations in the four-dimensional spacetime from the fivedimensional Einstein field equation. Besides the Einstein field equation in the four-dimensional spacetime, an electromagnetic field equation is obtained: ∇a F ab - ξ R b a A a = -4π J b with ξ = -2, where F ab is the antisymmetric electromagnetic field tensor defined by the potential vector A a , R ab is the Ricci curvature tensor of the hypersurface, and J a is the electric current density vector. The electromagnetic field equation differs from the Einstein-Maxwell equation by a curvature-coupled term ξ R b a A a , whose presence addresses the problem of incompatibility of the Einstein-Maxwell equation with a universe containing a uniformly distributed net charge, as discussed in a previous paper by the author [L.-X. Li, Gen. Relativ. Gravit. 48, 28 (2016)]. Hence, the new unified theory is physically different from Kaluza-Klein theory and its variants in which the Einstein-Maxwell equation is derived. In the four-dimensional Einstein field equation derived in the new theory, the source term includes the stress-energy tensor of electromagnetic fields as well as the stress-energy tensor of other unidentified matter. Under certain conditions the unidentified matter can be interpreted as a cosmological constant in the four-dimensional spacetime. We argue that, the electromagnetic field equation and hence the unified theory presented in this paper can be tested in an environment with a high mass density, e.g., inside a neutron star or a white dwarf, and in the early epoch of the universe.

  7. MBAT: A scalable informatics system for unifying digital atlasing workflows

    Directory of Open Access Journals (Sweden)

    Sane Nikhil

    2010-12-01

    Full Text Available Abstract Background Digital atlases provide a common semantic and spatial coordinate system that can be leveraged to compare, contrast, and correlate data from disparate sources. As the quality and amount of biological data continues to advance and grow, searching, referencing, and comparing this data with a researcher's own data is essential. However, the integration process is cumbersome and time-consuming due to misaligned data, implicitly defined associations, and incompatible data sources. This work addressing these challenges by providing a unified and adaptable environment to accelerate the workflow to gather, align, and analyze the data. Results The MouseBIRN Atlasing Toolkit (MBAT project was developed as a cross-platform, free open-source application that unifies and accelerates the digital atlas workflow. A tiered, plug-in architecture was designed for the neuroinformatics and genomics goals of the project to provide a modular and extensible design. MBAT provides the ability to use a single query to search and retrieve data from multiple data sources, align image data using the user's preferred registration method, composite data from multiple sources in a common space, and link relevant informatics information to the current view of the data or atlas. The workspaces leverage tool plug-ins to extend and allow future extensions of the basic workspace functionality. A wide variety of tool plug-ins were developed that integrate pre-existing as well as newly created technology into each workspace. Novel atlasing features were also developed, such as supporting multiple label sets, dynamic selection and grouping of labels, and synchronized, context-driven display of ontological data. Conclusions MBAT empowers researchers to discover correlations among disparate data by providing a unified environment for bringing together distributed reference resources, a user's image data, and biological atlases into the same spatial or semantic context

  8. Unifying Prepositions and Prefixes in Russian: Conceptual structure versus syntax

    Directory of Open Access Journals (Sweden)

    Inna Tolskaya

    2007-12-01

    Full Text Available This paper is an attempt to unify the polysemous verbal prefixes and prepositions in Russian. At first glance, the variety of possible denotations of a given prefix might appear a chaotic set of idiomatic meanings, e.g., the prefix za- may refer to beginning of an action, movement to a position behind an object, a brief deviation from a path, completion of an action, while the corresponding preposition za can mean ‘behind,’ ‘after,’ ‘for,’ ‘in’ (like in ‘in an hour’, ‘at’ (like in ‘at the table’. I will propose a unified analysis, where the differences in meaning are claimed to arise from different syntactic positions, while the lexical entry of a prefix remains the same. The main focus is on the verbs of motion due to the consistent duality displayed by the prefix meanings when added to directional and non-directional motion verbs. It will turn out that many prefixes appear to modify path when added onto a directional motion verb and to refer to movement in time with non-directional motion verbs. This semantic distinction corresponds to distinct sets of syntactic properties, specific for each set of prefixes. These two classes of prefixes correspond to the lexical versus superlexical distinction. However, a tripartite division will emerge in each set, corresponding to source, path, and goal of motion (FROM, VIA and TO for lexical prefixes and to initiation, process and result for superlexical prefixes. This leads to the suggestion that the syntactic representation of a VP contains at least six distinct nodes for the Russian verbal prefixes, each characterized by predictable semantic and syntactic properties. The same prefix with a consistent meaning, shared with the corresponding preposition, will receive part of its denotation from the syntactic head it attaches to, thus allowing the polysemy to arise from position, rather than from arbitrary homophony. Thus, conceptual structure will be unified with syntax.

  9. Nonlinear/linear unified thermal stress formulations - Transfinite element approach

    Science.gov (United States)

    Tamma, Kumar K.; Railkar, Sudhir B.

    1987-01-01

    A new unified computational approach for applicability to nonlinear/linear thermal-structural problems is presented. Basic concepts of the approach including applicability to nonlinear and linear thermal structural mechanics are first described via general formulations. Therein, the approach is demonstrated for thermal stress and thermal-structural dynamic applications. The proposed transfinite element approach focuses on providing a viable hybrid computational methodology by combining the modeling versatility of contemporary finite element schemes in conjunction with transform techniques and the classical Bubnov-Galerkin schemes. Comparative samples of numerical test cases highlight the capabilities of the proposed concepts.

  10. A unified cell biological perspective on axon-myelin injury.

    Science.gov (United States)

    Simons, Mikael; Misgeld, Thomas; Kerschensteiner, Martin

    2014-08-04

    Demyelination and axon loss are pathological hallmarks of the neuroinflammatory disorder multiple sclerosis (MS). Although we have an increasingly detailed understanding of how immune cells can damage axons and myelin individually, we lack a unified view of how the axon-myelin unit as a whole is affected by immune-mediated attack. In this review, we propose that as a result of the tight cell biological interconnection of axons and myelin, damage to either can spread, which might convert a local inflammatory disease process early in MS into the global progressive disorder seen during later stages. This mode of spreading could also apply to other neurological disorders.

  11. On the Feasibility of a Unified Modelling and Programming Paradigm

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth; Peleska, Jan

    2016-01-01

    , in particular for complex cyber-physical systems or systems of systems. Though modelling, programming, and verification will certainly become more closely integrated in the future, we do not expect a single formalism to become universally applicable and accepted by the development and verification communities......In this article, the feasibility of a unified modelling and programming paradigm is discussed from the perspective of large scale system development and verification in collaborative development environments. We motivate the necessity to utilise multiple formalisms for development and verification...

  12. Fluctuation-response relation unifies dynamical behaviors in neural fields

    Science.gov (United States)

    Fung, C. C. Alan; Wong, K. Y. Michael; Mao, Hongzi; Wu, Si

    2015-08-01

    Anticipation is a strategy used by neural fields to compensate for transmission and processing delays during the tracking of dynamical information and can be achieved by slow, localized, inhibitory feedback mechanisms such as short-term synaptic depression, spike-frequency adaptation, or inhibitory feedback from other layers. Based on the translational symmetry of the mobile network states, we derive generic fluctuation-response relations, providing unified predictions that link their tracking behaviors in the presence of external stimuli to the intrinsic dynamics of the neural fields in their absence.

  13. A unified slip boundary condition for flow over a surface

    CERN Document Server

    Thalakkottor, Joseph John

    2015-01-01

    Interface between two phases of matter are ubiquitous in nature and technology. Determining the correct velocity condition at an interface is essential for understanding and designing of flows over a surface. We demonstrate that both the widely used no-slip and the Navier and Maxwell slip boundary conditions do not capture the complete physics associated with complex problems, such as spreading of liquids or corner flows. Hence, we present a unified boundary condition that is applicable to a wide-range of flow problems.

  14. Toward a Unified Framework for Web Service Trustworthiness

    DEFF Research Database (Denmark)

    Miotto, N.; Dragoni, Nicola

    2012-01-01

    The intrinsic openness of the Service-Oriented Computing vision makes crucial to locate useful services and recognize them as trustworthy. What does it mean that a Web service is trustworthy? How can a software agent evaluate the trustworthiness of a Web service? In this paper we present an ongoing...... research aiming at providing an answer to these key issues to realize this vision. In particular, starting from an analysis of the weaknesses of current approaches, we discuss the possibility of a unified framework for Web service trustworthiness. The founding principle of our novel framework is that “hard...

  15. A unifying property for distribution-sensitive priority queues

    DEFF Research Database (Denmark)

    Elmasry, Amr Ahmed Abd Elmoneim; Farzan, Arash; Iacono, John

    2011-01-01

    , before) the last access of x and are still in the priority queue at the time when the corresponding operation is performed. Our priority queue then has both the working-set and the queueish properties; and, more strongly, it satisfies these properties in the worst-case sense. We also argue...... that these bounds are the best possible with respect to the considered measures. Moreover, we modify our priority queue to satisfy a new unifying property - the time-finger property - which encapsulates both the working-set and the queueish properties. In addition, we prove that the working-set bound...

  16. A new pressure-parametrization unified dark fluid model

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Deng [Nankai University, Theoretical Physics Division, Chern Institute of Mathematics, Tianjin (China); Yan, Yang-Jie; Meng, Xin-He [Nankai University, Department of Physics, Tianjin (China)

    2017-04-15

    We propose a new pressure-parametrization model to explain the accelerated expansion of the late-time Universe by considering the baryon matter and dark contents (dark matter and dark energy) as a unified dark fluid. To realize this model more physically, we reconstruct it with the quintessence and phantom scalar fields, respectively. We use the recent cosmological data to constrain this model, distinguish it from the standard cosmological model and find that the value of the Hubble constant H{sub 0} = 68.34{sup +0.53}{sub -0.92} supports the global measurement by the Planck satellite at the 1σ confidence level. (orig.)

  17. Unified communications forensics anatomy of common UC attacks

    CERN Document Server

    Grant, Nicholas Mr

    2013-01-01

    Unified Communications Forensics: Anatomy of Common UC Attacks is the first book to explain the issues and vulnerabilities and demonstrate the attacks, forensic artifacts, and countermeasures required to establish a secure (UC) environment. This book is written by leading UC experts Nicholas Grant and Joseph W. Shaw II and provides material never before found on the market, including: analysis of forensic artifacts in common UC attacks an in-depth look at established UC technologies and attack exploits hands-on understanding of UC attack vectors and associated countermeasures

  18. Development of the unified version of COBRA/RELAP5

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, J. J.; Ha, K. S.; Chung, B. D.; Lee, W. J.; Sim, S. K. [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1997-12-31

    The COBRA/RELAP5 code, an integrated version of the COBRA-TF and RELAP5/MOD3 codes, has been developed for the realistic simulations of complicated, multi-dimensional, two-phase, thermal-hydraulic system transients in light water reactors. Recently, KAERI developed an unified version of the COBRA/RELAP5 code, which can run in serial mode on both workstations and personal computers. This paper provides the brief overview of the code integration scheme, the recent code modifications, the developmental assessments, and the future development plan. 13 refs., 5 figs., 2 tabs. (Author)

  19. Unified Description of Tokamak Ideal MHD Instabilities(I)

    Institute of Scientific and Technical Information of China (English)

    石秉仁

    2002-01-01

    By using a coordinate system associated with magnetic surfaces,a unified eigenmode equation for describing the tokamak ideal MHD instabilities is derived in the shear-Alfven approximation.Based on this equation having a general operator form,the eigen-mode equation governing the large-scale perturbation (such as the kink mode,the low-n ballooning mode and the Alfven mode) and small-scale perturbation(such as the high-n ballooning mode,the local mode) can be further deduced.In the first part of the present study,the small-scale perturbation is discussed in detail.

  20. Horseshoe and entropy in a fractional-order unified system

    Institute of Scientific and Technical Information of China (English)

    Li Qing-Du; Chen Shu; Zhou Ping

    2011-01-01

    This paper studies chaotic dynamics in a fractional-order unified system by means of topological horseshoe theory the corresponding map is semiconjugate to a shift map with four symbols. By estimating the topological entropy of the map and the original time-continuous system, it provides a computer assisted verification on existence of chaos in this system, which is much more convincible than the common method of Lyapunov exponents. This new method can potentially be used in rigorous studies of chaos in such a kind of system. This paper may be a start for proving a given fractional-order differential equation to be chaotic.

  1. Logarithmic diffusion and porous media equations: a unified description.

    Science.gov (United States)

    Pedron, I T; Mendes, R S; Buratta, T J; Malacarne, L C; Lenzi, E K

    2005-09-01

    In this work we present the logarithmic diffusion equation as a limit case when the index that characterizes a nonlinear Fokker-Planck equation, in its diffusive term, goes to zero. A linear drift and a source term are considered in this equation. Its solution has a Lorentzian form, consequently this equation characterizes a superdiffusion like a Lévy kind. In addition an equation that unifies the porous media and the logarithmic diffusion equations, including a generalized diffusion equation in fractal dimension, is obtained. This unification is performed in the nonextensive thermostatistics context and increases the possibilities about the description of anomalous diffusive processes.

  2. Unified Description of Tokamak Ideal MHD Instabilities (Ⅰ)

    Institute of Scientific and Technical Information of China (English)

    石秉仁

    2002-01-01

    By using a coordinate system associated with magnetic surfaces, a unified eigen mode equation for describing the tokamak ideal MHD instabilities is derived in the shear-Alfven approximation. Based on this equation having a general operator form, the eigen-mode equation governing the large-scale perturbation (such as the kink mode, the low-n ballooning mode and the Alfven mode) and small-scale perturbation (such as the high-n ballooning mode, the local mode)can be further deduced. In the first part of the present study, the small-scale perturbation is discussed in detail.

  3. A unified tool for performance modelling and prediction

    Energy Technology Data Exchange (ETDEWEB)

    Gilmore, Stephen [Laboratory for Foundations of Computer Science, University of Edinburgh, King' s Buildings, Mayfield Road, Edinburgh, Scotland EH9 3JZ (United Kingdom)]. E-mail: stg@inf.ed.ac.uk; Kloul, Leila [Laboratory for Foundations of Computer Science, University of Edinburgh, King' s Buildings, Mayfield Road, Edinburgh, Scotland EH9 3JZ (United Kingdom)

    2005-07-01

    We describe a novel performability modelling approach, which facilitates the efficient solution of performance models extracted from high-level descriptions of systems. The notation which we use for our high-level designs is the Unified Modelling Language (UML) graphical modelling language. The technology which provides the efficient representation capability for the underlying performance model is the multi-terminal binary decision diagram (MTBDD)-based PRISM probabilistic model checker. The UML models are compiled through an intermediate language, the stochastic process algebra PEPA, before translation into MTBDDs for solution. We illustrate our approach on a real-world analysis problem from the domain of mobile telephony.

  4. A unified framework for Schelling's model of segregation

    CERN Document Server

    Rogers, Tim

    2011-01-01

    Schelling's model of segregation is one of the first and most influential models in the field of social simulation. There are many variations of the model which have been proposed and simulated over the last forty years, though the present state of the literature on the subject is somewhat fragmented and lacking comprehensive analytical treatments. In this article a unified mathematical framework for Schelling's model and its many variants is developed. This methodology is useful in two regards: firstly, it provides a tool with which to understand the differences observed between models; secondly, phenomena which appear in several model variations may be understood in more depth through analytic studies of simpler versions.

  5. A unified framework for Schelling's model of segregation

    Science.gov (United States)

    Rogers, Tim; McKane, Alan J.

    2011-07-01

    Schelling's model of segregation is one of the first and most influential models in the field of social simulation. There are many variations of the model which have been proposed and simulated over the last forty years, though the present state of the literature on the subject is somewhat fragmented and lacking comprehensive analytical treatments. In this paper a unified mathematical framework for Schelling's model and its many variants is developed. This methodology is useful in two regards: firstly, it provides a tool with which to understand the differences observed between models; secondly, phenomena which appear in several model variations may be understood in more depth through analytic studies of simpler versions.

  6. Baryon number violation catalysed by grand unified monopoles

    CERN Document Server

    Ellis, Jonathan Richard; Olive, Keith A

    1982-01-01

    It has been recognized for some time that grand unified monopoles may catalyze Delta B not=0 processes. The authors obtain model-independent upper bounds on the rates for such reactions from the survival of the baryon number generated in the early Universe and from present-day baryon stability. These constraints are compatible with recent estimates of large baryon number violating monopole cross sections, but a monopole flux close to present experimental upper limits could be detectable in forthcoming baryon decay experiments. The authors mention signatures for monopole-induced baryon 'decay' and point out that it could be used to solve the energy crisis.

  7. Unifying CP violations of quark and lepton sectors

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jihn E., E-mail: jihnekim@gmail.com [Department of Physics, Kyung Hee University, 26 Gyungheedaero, Dongdaemun-Gu, 02447, Seoul (Korea, Republic of); Center for Axion and Precision Physics Research (IBS), 291 Daehakro, Yuseong-Gu, 34141, Taejon (Korea, Republic of); Department of Physics, Seoul National University, 1 Gwanakro, Gwanak-Gu, 08826, Seoul (Korea, Republic of); Nam, Soonkeon [Department of Physics, Kyung Hee University, 26 Gyungheedaero, Dongdaemun-Gu, 02447, Seoul (Korea, Republic of)

    2016-01-08

    A preliminary determination of the Dirac phase in the PMNS matrix is δ{sub PMNS}≈-(π/2). A rather accurately determined Jarlskog invariant J in the CKM matrix is close to the maximum. Since the phases in the CKM and PMNS matrices will be accurately determined in the future, it is an interesting problem to relate these two phases. This can be achieved in a families-unified grand unification if the weak CP violation is introduced spontaneously à la Froggatt and Nielsen at a high energy scale, where only one meaningful Dirac CP phase appears.

  8. Unifying CP violations of quark and lepton sectors

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jihn E. [Kyung Hee University, Department of Physics, Seoul (Korea, Republic of); Center for Axion and Precision Physics Research (IBS), Taejon (Korea, Republic of); Seoul National University, Department of Physics, Seoul (Korea, Republic of); Nam, Soonkeon [Kyung Hee University, Department of Physics, Seoul (Korea, Republic of)

    2015-12-15

    A preliminary determination of the Dirac phase in the PMNS matrix is δ{sub PMNS} ∼ -(π)/(2). A rather accurately determined Jarlskog invariant J in the CKM matrix is close to the maximum. Since the phases in the CKM and PMNS matrices will be accurately determined in the future, it is an interesting problem to relate these two phases. This can be achieved in a families-unified grand unification if the weak CP violation is introduced spontaneously a la Froggatt and Nielsen at a high energy scale, where only one meaningful Dirac CP phase appears. (orig.)

  9. A unified minimax result for restricted parameter spaces

    CERN Document Server

    Marchand, Éric; 10.3150/10-BEJ336

    2012-01-01

    We provide a development that unifies, simplifies and extends considerably a number of minimax results in the restricted parameter space literature. Various applications follow, such as that of estimating location or scale parameters under a lower (or upper) bound restriction, location parameter vectors restricted to a polyhedral cone, scale parameters subject to restricted ratios or products, linear combinations of restricted location parameters, location parameters bounded to an interval with unknown scale, quantiles for location-scale families with parametric restrictions and restricted covariance matrices.

  10. LDRD final report on a unified linear reference system

    Energy Technology Data Exchange (ETDEWEB)

    Espinoza, J. Jr.; Mackoy, R.D. [Sandia National Labs., Albuquerque, NM (United States). Decision Support Systems Software Engineering Dept.; Fletcher, D.R. [Univ. of New Mexico, Albuquerque, NM (United States). Alliance for Transportation Research

    1997-06-01

    The purpose of the project was to describe existing deficiencies in Geographic Information Systems for transportation (GIS-T) applications and prescribe solutions that would benefit the transportation community in general. After an in-depth literature search and much consultation with noted transportation experts, the need for a common linear reference system that integrated and supported the planning and operational needs of the transportation community became very apparent. The focus of the project was set on a unified linear reference system and how to go about its requirements definition, design, implementation, and promulgation to the transportation community.

  11. Universality of efficiency at unified trade-off optimization.

    Science.gov (United States)

    Zhang, Yanchao; Huang, Chuankun; Lin, Guoxing; Chen, Jincan

    2016-03-01

    We calculate the efficiency at the unified trade-off optimization criterion (the so-called maximum Ω criterion) representing a compromise between the useful energy and the lost energy of heat engines operating between two reservoirs at different temperatures and chemical potentials, and demonstrate that the linear coefficient 3/4 and quadratic coefficient 1/32 of the efficiency at maximum Ω are universal for heat engines under strong coupling and symmetry conditions. It is further proved that the conclusions obtained here also apply to the ecological optimization criterion.

  12. Unified universe history through phantom extended Chaplygin gas

    CERN Document Server

    Pourhassan, B

    2015-01-01

    We investigate the universe evolution from inflation to late-time acceleration in a unified way, using a two-component fluid constituted from extended Chaplygin gas alongside a phantom scalar field. We extract solutions for the various cosmological eras, focusing on the behavior of the scale factor, the various density parameters and the equation-of-state parameter. Furthermore, we extract and discuss bouncing solutions. Finally, we examine the perturbations of the model, ensuring about their stability and extracting the predictions for the tensor-to-scalar ratio.

  13. Unified mass-action theory for virus neutralization and radioimmunology.

    Science.gov (United States)

    Trautman, R

    1976-01-01

    All ideas implicit in the papers since 1953 involved in applying mass-action thermodynamics to antibody-antigen reactions are unified by the use of: (a) the intermediary concept of extent of reaction; (b) the concept of intrinsic association constant; (c) a statistical analysis for probable complexes; and (d) identification of the complex or complexes that contribute to the bioassay. Several general theoretical examples are given that show the limitations of linear interpretations of equilibrium data. Two practical examples from the literature illustrate foot-and-mouth disease virus and influenza virus neutralization.

  14. A Unified Computational Model for Solar and Stellar Flares

    OpenAIRE

    Allred, Joel C.; Kowalski, Adam F.; Carlsson, Mats

    2015-01-01

    We present a unified computational framework which can be used to describe impulsive flares on the Sun and on dMe stars. The models assume that the flare impulsive phase is caused by a beam of charged particles that is accelerated in the corona and propagates downward depositing energy and momentum along the way. This rapidly heats the lower stellar atmosphere causing it to explosively expand and dramatically brighten. Our models consist of flux tubes that extend from the sub-photosphere into...

  15. Peningkatan Available Transfer Capability Mengggunakan Unified Power Flow Controller

    Directory of Open Access Journals (Sweden)

    Adyatmoko Wirananto

    2012-09-01

    Full Text Available Available Transfer Capability (ATC adalah kemampuan transfer yang masih mungkin bisa dilakukan pada sistem tenaga listrik. Pemasangan perangkat FACTS, yaitu Unified Power Flow Controller (UPFC dilakukan untuk meningkatkan nilai ATC. UPFC akan mengontrol injeksi daya reaktif dan mengontrol tegangan pada saluran transmisi yang dipasangi UPFC sehingga akan merubah aliran daya pada sistem tenaga listrik. Melalui analisis optimal power flow pada Sistem IEEE 14 bus, variabel-variabel kontrol akan diinjeksikan dari UPFC ke aliran daya Sistem IEEE 14 bus. Setelah dipasang UPFC sistem mampu mencapai nilai load margin maksimal pada 0,1511 ketika UPFC dipasang di Saluran 2-5, dengan ATC yang dicapai adalah 35,38 MW.

  16. Skinner Rusk unified formalism for optimal control systems and applications

    Science.gov (United States)

    Barbero-Liñán, María; Echeverría-Enríquez, Arturo; Martín de Diego, David; Muñoz-Lecanda, Miguel C.; Román-Roy, Narciso

    2007-10-01

    A geometric approach to time-dependent optimal control problems is proposed. This formulation is based on the Skinner and Rusk formalism for Lagrangian and Hamiltonian systems. The corresponding unified formalism developed for optimal control systems allows us to formulate geometrically the necessary conditions given by a weak form of Pontryagin's maximum principle, provided that the differentiability with respect to controls is assumed and the space of controls is open. Furthermore, our method is also valid for implicit optimal control systems and, in particular, for the so-called descriptor systems (optimal control problems including both differential and algebraic equations).

  17. A method for unified optimization of systems and controllers

    DEFF Research Database (Denmark)

    Abildgaard, Ole

    1990-01-01

    A unified method for solving control system optimization problems is suggested. All system matrices are allowed to be functions of the design variables. The method makes use of an implementation of a sequential quadratic programming algorithm (NLPQL) for solution of general constrained nonlinear...... programming problems. It is shown how to compute the gradients of the objective function and the constraint functions imposing eigenvalue constraints. In an example it is demonstrated how the method can solve a high-dimensional problem, where the initial condition covariance assumption is used to ensure...

  18. Towards a unified description of the electroweak nuclear response

    CERN Document Server

    Benhar, Omar

    2015-01-01

    We briefly review the growing efforts to set up a unified framework for the description of neutrino interactions with atomic nuclei and nuclear matter, applicable in the broad kinematical region corresponding to neutrino energies ranging between few MeV and few GeV. The emerging picture suggests that the formalism of nuclear many-body theory can be exploited to obtain the neutrino-nucleus cross sections needed for both the interpretation of oscillation signals and simulation of neutrino transport in compact stars.

  19. A Unified Semantic Framework for the description of assistive technologies.

    Science.gov (United States)

    Konstadinidou, Aggeliki; Kaklanis, Nikolaos; Votis, Konstantinos; Tzovaras, Dimitrios

    2015-01-01

    This paper presents the Semantic Alignment Tool, a unified, classified, ontological framework, for the description of assistive solutions that comprises information from different sources automatically. The Semantic Alignment Tool is a component of the Cloud4All/GPII infrastructure that enables users to add and/or modify descriptions of assistive technologies and align their specific settings with similar settings in an ontological model based on ISO 9999. The current work presents the interaction of the Semantic Alignment Tool with external sources that contain descriptions and metadata for Assistive Technologies (ATs) in order to achieve their synchronization in the same semantic model.

  20. A Grammar Analysis Model for the Unified Multimedia Query Language

    Institute of Scientific and Technical Information of China (English)

    Zhong-Sheng Cao; Zong-Da Wu; Yuan-Zhen Wang

    2008-01-01

    The unified multimedia query language(UMQL) is a powerful general-purpose multimediaquery language, and it is very suitable for multimediainformation retrieval. The paper proposes a grammaranalysis model to implement an effective grammaticalprocessing for the language. It separates the grammaranalysis of a UMQL query specification into two phases:syntactic analysis and semantic analysis, and thenrespectively uses Backus-Naur form (EBNF) and logicalalgebra to specify both restrictive grammar rules. As aresult, the model can present error guiding informationfor a query specification which owns incorrect grammar.The model not only suits well the processing of UMQLqueries, but also has a guiding significance for otherprojects concerning query processings of descriptivequery languages.

  1. Unifying model for two-state and downhill protein folding

    Science.gov (United States)

    Mi, D.; Meng, W. Q.; Sun, Y. Q.

    2011-04-01

    A protein-folding model is proposed at the amino acid level, in which the folding process is divided into two successive stages: the rate-determining step, dominated by the “stochastic interactions”of solvent molecules, and the rapid phase, dominated by the “order interactions”among atoms in polypeptide. The master equation approach is used to investigate the folding kinetics, and an analytical treatment of the master equation yields a simple three-parameter expression for folding time. It is found that both two-state and downhill protein-folding kinetics can be described by a unifying model.

  2. The strong coupling constant in grand unified theories

    Energy Technology Data Exchange (ETDEWEB)

    Pierce, D.M.

    1997-01-01

    The prediction of the strong coupling constant in grand unified theories is reviewed, first in the standard model, then in the supersymmetric version. Various corrections are considered. The predictions in both supergravity-induced and gauge-mediated supersymmetry breaking models are discussed. In the region of parameter space without large fine tuning the strong coupling is predicted to be {alpha}{sub s} (M{sub Z}) {approx}> 0.13. Imposing {alpha}{sub s} (M{sub Z}) = 0.118, the authors require a unification scale threshold correction of typically -2%, which is accommodated by some GUT models but in conflict with others.

  3. A unified approach to mapping and clustering of bibliometric networks

    CERN Document Server

    Waltman, Ludo; Noyons, Ed C M

    2010-01-01

    In the analysis of bibliometric networks, researchers often use mapping and clustering techniques in a combined fashion. Typically, however, mapping and clustering techniques that are used together rely on very different ideas and assumptions. We propose a unified approach to mapping and clustering of bibliometric networks. We show that the VOS mapping technique and a weighted and parameterized variant of modularity-based clustering can both be derived from the same underlying principle. We illustrate our proposed approach by producing a combined mapping and clustering of the most frequently cited publications that appeared in the field of information science in the period 1999-2008.

  4. A Unifying Theory for Scaling Laws of Human Populations

    CERN Document Server

    Lin, Henry W

    2015-01-01

    The spatial distribution of people exhibits clustering across a wide range of scales, from household (~$10^{-2}$ km) to continental (~$10^4$ km) scales. Empirical data indicates simple power-law scalings for the size distribution of cities (known as Zipf's law), the geographic distribution of friends, and the population density fluctuations as a function of scale. We derive a simple statistical model that explains all of these scaling laws based on a single unifying principle involving the random spatial growth of clusters of people on all scales. The model makes important new predictions for the spread of diseases and other social phenomena.

  5. Unified Modeling of Complex Real-Time Control Systems

    CERN Document Server

    Hai, He; Chi-Lan, Cai

    2011-01-01

    Complex real-time control system is a software dense and algorithms dense system, which needs modern software engineering techniques to design. UML is an object-oriented industrial standard modeling language, used more and more in real-time domain. This paper first analyses the advantages and problems of using UML for real-time control systems design. Then, it proposes an extension of UML-RT to support time-continuous subsystems modeling. So we can unify modeling of complex real-time control systems on UML-RT platform, from requirement analysis, model design, simulation, until generation code.

  6. Unified analysis of pressure melting of ice around horizontal columns

    Institute of Scientific and Technical Information of China (English)

    LIU Feng; CHEN Wenzhen; MENG Bin; GONG Miao

    2007-01-01

    The contact melting processes of ice, caused by pressure under the two-dimension axisymmetric horizontal columns, are generally studied. The unified mathematical expressions of the characteristic parameters for the pressure contact melting processes are obtained. Applying these expressions to the analysis of the pressure contact melting of ice around the horizontal cylinder, elliptical cylinder and flat plate, the related results in the published literatures are obtained, which prove the correctness and validity of the expressions. In addition, the expressions for the pressure contact melting of ice around the wedge-shaped object are also derived.

  7. Unified description of light- and strange-baryon spectra

    CERN Document Server

    Glozman, L Ya; Varga, K; Wagenbrunn, R F

    1998-01-01

    We present a chiral constituent quark model for light and strange baryons providing a unified description of their ground states and excitation spectra. The model relies on constituent quarks and Goldstone bosons arising as effective degrees of freedom of low-energy QCD from the spontaneous breaking of chiral symmetry. The spectra of the three-quark systems are obtained from a precise variational solution of the Schrödinger equation with a semirelativistic Hamiltonian. The theoretical predictions are found in close agreement with experiment.

  8. A unified constructive network model for problem-solving.

    Science.gov (United States)

    Takahashi, Y

    1996-01-01

    We develop a neural network model that relieves time-consuming trial-and-error computer experiments usually performed in problem-solving with networks where problems, including the traveling salesman problem, pattern matching and pattern classification/learning, are formulated as optimization problems with constraint. First, we specify and uniquely distinguish the model as a set of constituent functions that should comply with restrictive conditions. Next, we demonstrate that it is unified, i.e., it yields most current networks. Finally, we verify that it is constructive, that is, we show a standard method that systematically constructs from a given optimization problem a particular network in that model to solve it.

  9. Quantum Machine and SR Approach: a Unified Model

    CERN Document Server

    Garola, C; Sozzo, S; Garola, Claudio; Pykacz, Jaroslav; Sozzo, Sandro

    2005-01-01

    The Geneva-Brussels approach to quantum mechanics (QM) and the semantic realism (SR) nonstandard interpretation of QM exhibit some common features and some deep conceptual differences. We discuss in this paper two elementary models provided in the two approaches as intuitive supports to general reasonings and as a proof of consistency of general assumptions, and show that Aerts' quantum machine can be embodied into a macroscopic version of the microscopic SR model, overcoming the seeming incompatibility between the two models. This result provides some hints for the construction of a unified perspective in which the two approaches can be properly placed.

  10. A Unified Differential Evolution Algorithm for Global Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Qiang, Ji; Mitchell, Chad

    2014-06-24

    Abstract?In this paper, we propose a new unified differential evolution (uDE) algorithm for single objective global optimization. Instead of selecting among multiple mutation strategies as in the conventional differential evolution algorithm, this algorithm employs a single equation as the mutation strategy. It has the virtue of mathematical simplicity and also provides users the flexbility for broader exploration of different mutation strategies. Numerical tests using twelve basic unimodal and multimodal functions show promising performance of the proposed algorithm in comparison to convential differential evolution algorithms.

  11. Unified Electronic Currency Based on the Fourth Party Platform Integrated Payment Service

    Science.gov (United States)

    Yong, Xu; Qiqi, Hu

    This paper presents a solution of unified e-currency based on the fourth party platform integrated payment service. The purpose of the paper is to solve the problem of distribution and resource-wasting caused by the lack of unified electronic currency, and to solve regulatory difficulties due to regulation size caused by a wide variety of e-currency. Methods: This article first analyzes the problems in the development of electronic money, and then proposes the concept of a unified electronic currency based on the fourth party platform integrated payment service. Besides, it proposes a unified mechanism and transaction procedures for unified e-currency, and analyzes the liquidation process, security and regulatory requirements, which are involved in using unified electronic currency.

  12. Development of a unified viscoplasticity constitutive model based on classical plasticity theory

    Institute of Scientific and Technical Information of China (English)

    GUAN Ping; LIU ChangChun; L(U) HeXiang

    2009-01-01

    The traditional unified viscoplasticity constitutive model can be only applied to metal materials. The study of the unified constitutive theory for metal materials has discovered the correlation between the classical plasticity theory and the unified viscoplasticity constitutive model, thus leading to the con-cepts of the classic plastic potential and yield surface in the unified constitutive model. Moreover, this research has given the continuous expression of the classical plastic multiplier and presented the corresponding constructive method, which extends its physical significance and lays down a good foundation for the application of the unified constitutive theory to the material analysis in more fields.This paper also introduces the unified constitutive model for metal materials and geo-materials. The numerical simulation indicates that the construction should be both reasonable and practical.

  13. Development of a unified viscoplasticity constitutive model based on classical plasticity theory

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The traditional unified viscoplasticity constitutive model can be only applied to metal materials.The study of the unified constitutive theory for metal materials has discovered the correlation between the classical plasticity theory and the unified viscoplasticity constitutive model,thus leading to the con-cepts of the classic plastic potential and yield surface in the unified constitutive model.Moreover,this research has given the continuous expression of the classical plastic multiplier and presented the corresponding constructive method,which extends its physical significance and lays down a good foundation for the application of the unified constitutive theory to the material analysis in more fields.This paper also introduces the unified constitutive model for metal materials and geo-materials.The numerical simulation indicates that the construction should be both reasonable and practical.

  14. Perturbation to Unified Symmetry and Adiabatic Invariants for Relativistic Hamilton Systems

    Institute of Scientific and Technical Information of China (English)

    ZHANG Ming-Jiang; FANG Jian-Hui; LU Kai; PANG Ting; LIN Peng

    2009-01-01

    Based on the concept of adiabatic invariant, the perturbation to unified symmetry and adiabatic invariants for relativistic Hamilton systems are studied. The definition of the perturbation to unified symmetry for the system is presented, and the criterion of the perturbation to unified symmetry is given. Meanwhile, the Noether adiabatic invariants, the generalized Hojman adiabatic invariants, and the Mei adiabatic invariants for the perturbed system are obtained.

  15. 6 Schools that Make a Difference: With the Support of Focus on Results, These Six Schools Beat the Odds by Using Common Sense Strategies in a Focused Effort to Improve Student Achievement

    Science.gov (United States)

    Cudeiro, Amalia; Palumbo, Joe; Leight, Jan; Nelsen, Jeff

    2005-01-01

    More and more schools in California and across the nation are showing that when school communities accept the possibility and responsibility of bringing all of their students to proficiency levels, they can do amazing things. Six schools located in southern California--Martin Luther King and Harvey of Santa Ana Unified, Morrison Elementary of…

  16. GUDM: Automatic Generation of Unified Datasets for Learning and Reasoning in Healthcare.

    Science.gov (United States)

    Ali, Rahman; Siddiqi, Muhammad Hameed; Idris, Muhammad; Ali, Taqdir; Hussain, Shujaat; Huh, Eui-Nam; Kang, Byeong Ho; Lee, Sungyoung

    2015-07-02

    A wide array of biomedical data are generated and made available to healthcare experts. However, due to the diverse nature of data, it is difficult to predict outcomes from it. It is therefore necessary to combine these diverse data sources into a single unified dataset. This paper proposes a global unified data model (GUDM) to provide a global unified data structure for all data sources and generate a unified dataset by a "data modeler" tool. The proposed tool implements user-centric priority based approach which can easily resolve the problems of unified data modeling and overlapping attributes across multiple datasets. The tool is illustrated using sample diabetes mellitus data. The diverse data sources to generate the unified dataset for diabetes mellitus include clinical trial information, a social media interaction dataset and physical activity data collected using different sensors. To realize the significance of the unified dataset, we adopted a well-known rough set theory based rules creation process to create rules from the unified dataset. The evaluation of the tool on six different sets of locally created diverse datasets shows that the tool, on average, reduces 94.1% time efforts of the experts and knowledge engineer while creating unified datasets.

  17. 14 CFR 1221.108 - Establishment of the NASA Unified Visual Communications System.

    Science.gov (United States)

    2010-01-01

    ..., reproduction art, stationery, forms, publications, signs, films, video productions, vehicles, aircraft, and spacecraft markings and other items. It creates a unified image which is representative and symbolic of...

  18. Power system security enhancement with unified power flow controller under multi-event contingency conditions

    National Research Council Canada - National Science Library

    S. Ravindra; Chintalapudi V. Suresh; S. Sivanagaraju; V.C. Veera Reddy

    2017-01-01

    .... An improved teaching learning based optimization (ITLBO) algorithm has been presented. To enhance the system security under contingency conditions in the presence of unified power flow controller (UPFC...

  19. GUDM: Automatic Generation of Unified Datasets for Learning and Reasoning in Healthcare

    Directory of Open Access Journals (Sweden)

    Rahman Ali

    2015-07-01

    Full Text Available A wide array of biomedical data are generated and made available to healthcare experts. However, due to the diverse nature of data, it is difficult to predict outcomes from it. It is therefore necessary to combine these diverse data sources into a single unified dataset. This paper proposes a global unified data model (GUDM to provide a global unified data structure for all data sources and generate a unified dataset by a “data modeler” tool. The proposed tool implements user-centric priority based approach which can easily resolve the problems of unified data modeling and overlapping attributes across multiple datasets. The tool is illustrated using sample diabetes mellitus data. The diverse data sources to generate the unified dataset for diabetes mellitus include clinical trial information, a social media interaction dataset and physical activity data collected using different sensors. To realize the significance of the unified dataset, we adopted a well-known rough set theory based rules creation process to create rules from the unified dataset. The evaluation of the tool on six different sets of locally created diverse datasets shows that the tool, on average, reduces 94.1% time efforts of the experts and knowledge engineer while creating unified datasets.

  20. A Unified Framework for Multilingual Text-to-Speech Synthesis with SSML Specification as Interface

    Institute of Scientific and Technical Information of China (English)

    WU Zhiyong; CAO Guangqi; MENG M. Helen; CAI Lianhong

    2009-01-01

    This paper describes the design of a unified framework for a multilingual text-to-speech (TTS) synthesis engine -Crystal. The unified framework defines the common TTS modules for different languages and/or dialects. The interfaces between consecutive modules conform to the speech synthesis markup lan-guage (SSML) specification for standardization, interoperability, mulUlinguality, and extensibility. Detailed module divisions and implementation technologies for the unified framework are introduced, together with possible extensions for the algorithm research and evaluation of the TTS synthesis. Implementation of a mixed-language TTS system for Chinese Putonghua, Chinese Cantonese, and English demonstrates the feasibility of the proposed unified framework.

  1. Robust finite-time stabilization of unified chaotic complex systems with certain and uncertain parameters

    Science.gov (United States)

    Liu, Ping

    2013-07-01

    This paper deals with the finite-time stabilization of unified chaotic complex systems with known and unknown parameters. Based on the finite-time stability theory, nonlinear control laws are presented to achieve finite-time chaos control of the determined and uncertain unified chaotic complex systems, respectively. The two controllers are simple, and one of the uncertain unified chaotic complex systems is robust. For the design of a finite-time controller on uncertain unified chaotic complex systems, only some of the unknown parameters need to be bounded. Simulation results for the chaotic complex Lorenz, Lü and Chen systems are presented to validate the design and analysis.

  2. A Unifying Model of Orientation Crowding in Peripheral Vision.

    Science.gov (United States)

    Harrison, William J; Bex, Peter J

    2015-12-21

    Peripheral vision is fundamentally limited not by the visibility of features, but by the spacing between them [1]. When too close together, visual features can become "crowded" and perceptually indistinguishable. Crowding interferes with basic tasks such as letter and face identification and thus informs our understanding of object recognition breakdown in peripheral vision [2]. Multiple proposals have attempted to explain crowding [3], and each is supported by compelling psychophysical and neuroimaging data [4-6] that are incompatible with competing proposals. In general, perceptual failures have variously been attributed to the averaging of nearby visual signals [7-10], confusion between target and distractor elements [11, 12], and a limited resolution of visual spatial attention [13]. Here we introduce a psychophysical paradigm that allows systematic study of crowded perception within the orientation domain, and we present a unifying computational model of crowding phenomena that reconciles conflicting explanations. Our results show that our single measure produces a variety of perceptual errors that are reported across the crowding literature. Critically, a simple model of the responses of populations of orientation-selective visual neurons accurately predicts all perceptual errors. We thus provide a unifying mechanistic explanation for orientation crowding in peripheral vision. Our simple model accounts for several perceptual phenomena produced by crowding of orientation and raises the possibility that multiple classes of object recognition failures in peripheral vision can be accounted for by a single mechanism.

  3. The Goddard multi-scale modeling system with unified physics

    Directory of Open Access Journals (Sweden)

    W.-K. Tao

    2009-08-01

    Full Text Available Recently, a multi-scale modeling system with unified physics was developed at NASA Goddard. It consists of (1 a cloud-resolving model (CRM, (2 a regional-scale model, the NASA unified Weather Research and Forecasting Model (WRF, and (3 a coupled CRM-GCM (general circulation model, known as the Goddard Multi-scale Modeling Framework or MMF. The same cloud-microphysical processes, long- and short-wave radiative transfer and land-surface processes are applied in all of the models to study explicit cloud-radiation and cloud-surface interactive processes in this multi-scale modeling system. This modeling system has been coupled with a multi-satellite simulator for comparison and validation with NASA high-resolution satellite data.

    This paper reviews the development and presents some applications of the multi-scale modeling system, including results from using the multi-scale modeling system to study the interactions between clouds, precipitation, and aerosols. In addition, use of the multi-satellite simulator to identify the strengths and weaknesses of the model-simulated precipitation processes will be discussed as well as future model developments and applications.

  4. New unified fracture toughness estimation scheme for structural integrity assessment

    Energy Technology Data Exchange (ETDEWEB)

    Wallin, K.; Nevasmaa, P. [VTT, Espoo (Finland); Bannister, A. [Research and Development, British Steel plc., Swinden Technology Centre Rotherham (United Kingdom)

    1998-12-31

    At present, treatment of fracture toughness data varies depending on the type of data (K{sub IC}, J, CTOD) that are available for fracture mechanics analysis. This complicates structural integrity assessment and makes it difficult to apply any single, unified procedure. Within the Brite-Euram project `SINTAP` a fracture toughness estimation scheme has been developed for the unified treatment of data for use in structural integrity assessment. As a procedure, it can be applied to Charpy data, as well as to fracture toughness data, and is suitable for the treatment of data at both single and different temperatures. The data sets may contain results from both homogeneous and inhomogeneous material, making the procedure applicable also to welded joints. The procedure allows fracture toughness assessment with quantified probability and confidence levels. Irrespective of the type of the original data, one material-specific K{sub mat} value representing a conservative estimate of the mean fracture toughness is obtained (with its probability distribution). This information can then be applied to structural integrity assessment. (orig.) 4 refs.

  5. Unified solutions of extended Gauss-Bonnet gravity

    Science.gov (United States)

    Keskin, A. I.; Açıkgöz, I.

    2016-12-01

    We study some scale factor power-law solutions of the field equations of the extended Gauss Bonnet gravity in the spatial FRW (Friedmann-Robertson-Walker) universe. We consider the lagrangian density given by F ( R, G ) =f ( G ) + R + α R2 which exhibits a modification comparing with the modified Gauss Bonnet gravity. After constructing the Friedmann equations and finding the power-law solution we obtain the real valued of our model describing a mechanism that shows transitions among three stages of the universe (inflation, deceleration, acceleration) in an unified way. In particular, in this unified solution we obtained an inflation model without using any scalar field description when α>0, and also we verified our early time inflationary scenario using observational parameters, i.e. ns, r. Further, we research for the power-law solution of our model when the universe is in the phantom phase. Here, it is observed that the acceleration of the universe in phantom region is composed of two phases which congruent with the recent observations.

  6. A unified theory of calcium alternans in ventricular myocytes

    Science.gov (United States)

    Qu, Zhilin; Liu, Michael B.; Nivala, Michael

    2016-01-01

    Intracellular calcium (Ca2+) alternans is a dynamical phenomenon in ventricular myocytes, which is linked to the genesis of lethal arrhythmias. Iterated map models of intracellular Ca2+ cycling dynamics in ventricular myocytes under periodic pacing have been developed to study the mechanisms of Ca2+ alternans. Two mechanisms of Ca2+ alternans have been demonstrated in these models: one relies mainly on fractional sarcoplasmic reticulum Ca2+ release and uptake, and the other on refractoriness and other properties of Ca2+ sparks. Each of the two mechanisms can partially explain the experimental observations, but both have their inconsistencies with the experimental results. Here we developed an iterated map model that is composed of two coupled iterated maps, which unifies the two mechanisms into a single cohesive mathematical framework. The unified theory can consistently explain the seemingly contradictory experimental observations and shows that the two mechanisms work synergistically to promote Ca2+ alternans. Predictions of the theory were examined in a physiologically-detailed spatial Ca2+ cycling model of ventricular myocytes. PMID:27762397

  7. Supersymmetric axion grand unified theories and their predictions

    Science.gov (United States)

    Co, Raymond T.; D'Eramo, Francesco; Hall, Lawrence J.

    2016-10-01

    We introduce a class of unified supersymmetric axion theories with unified and Peccei-Quinn (PQ) symmetries broken by the same set of fields at a scale ˜2 ×1 016 GeV . A typical domain wall number of order 30 leads to an axion decay constant fa of order 1 015 GeV . Inflation generates a large saxion condensate, giving a reheat temperature TR below the QCD scale for supersymmetry breaking of order 1-10 TeV. Axion field oscillations commence in the saxion matter-dominated era near the QCD scale, and recent lattice computations of the temperature dependence of the axion mass in this era allow a controlled calculation of the axion dark matter abundance. The observed abundance can be successfully explained by an initial axion misalignment angle of order unity, θi˜1 . A highly correlated set of predictions is discussed for fa, TR, the supersymmetric Higgs mass parameter μ , the amount of dark radiation Δ Neff, the proton decay rate Γ (p →e+π0), isocurvature density perturbations and the B mode of the cosmic microwave background. The last two are particularly interesting when the energy scale of inflation is also of order 1 016 GeV .

  8. Finite element analysis of structures through unified formulation

    CERN Document Server

    Carrera, Erasmo; Petrolo, Marco; Zappino, Enrico

    2014-01-01

    The finite element method (FEM) is a computational tool widely used to design and analyse  complex structures. Currently, there are a number of different approaches to analysis using the FEM that vary according to the type of structure being analysed: beams and plates may use 1D or 2D approaches, shells and solids 2D or 3D approaches, and methods that work for one structure are typically not optimized to work for another. Finite Element Analysis of Structures Through Unified Formulation deals with the FEM used for the analysis of the mechanics of structures in the case of linear elasticity. The novelty of this book is that the finite elements (FEs) are formulated on the basis of a class of theories of structures known as the Carrera Unified Formulation (CUF). It formulates 1D, 2D and 3D FEs on the basis of the same ''fundamental nucleus'' that comes from geometrical relations and Hooke''s law, and presents both 1D and 2D refined FEs that only have displacement variables as in 3D elements. It also covers 1D...

  9. A word from the DG: A unified Laboratory

    CERN Multimedia

    2008-01-01

    I complete my five years at the helm of CERN at the end of December and would like to take this opportunity to remind you of the route we have travelled during that time and to express my best wishes to you for the future. In addition to the vital priority of completing the LHC, I set myself two essential goals at the beginning of my term of office: to define a clear long-term strategy for CERN and to unify the Laboratory. These aims were essential in order to regain the confidence of the Member States, partly lost as a result of the crisis that occurred before I took up office, and to transform CERN into the key player in the European strategy for particle physics. We have succeeded in completing the LHC. Despite the incident in the machine, we were able to show very rapidly that the accelerator and its injection chain were well poised to deliver efficient operation and use. Our efforts to unify the Laboratory, to define the strateg...

  10. Modern Fysics Phallacies: The Best Way Not to Unify Physics

    Science.gov (United States)

    Beichler, James E.

    Too many physicists believe the `phallacy' that the quantum is more fundamental than relativity without any valid supporting evidence, so the earliest attempts to unify physics based on the continuity of relativity have been all but abandoned. This belief is probably due to the wealth of pro-quantum propaganda and general `phallacies in fysics' that were spread during the second quarter of the twentieth century, although serious `phallacies' exist throughout physics on both sides of the debate. Yet both approaches are basically flawed because both relativity and the quantum theory are incomplete and grossly misunderstood as they now stand. Had either side of the quantum versus relativity controversy sought common ground between the two worldviews, total unification would have been accomplished long ago. The point is, literally, that the discrete quantum, continuous relativity, basic physical geometry, theoretical mathematics and classical physics all share one common characteristic that has never been fully explored or explained - a paradoxical duality between a dimensionless point (discrete) and an extended length (continuity) in any dimension - and if the problem of unification is approached from an understanding of how this paradox relates to each paradigm, all of physics and indeed all of science could be unified under a single new theoretical paradigm.

  11. Effective Utilization of Multicore Processor for Unified Threat Management Functions

    Directory of Open Access Journals (Sweden)

    Radhakrishnan Shanmugasundaram

    2012-01-01

    Full Text Available Problem statement: Multicore and multithreaded CPUs have become the new approach for increase in the performance of the processor based systems. Numerous applications benefit from use of multiple cores. Unified threat management is one such application that has multiple functions to be implemented at high speeds. Increasing performance of the system by knowing the nature of the functionality and effective utilization of multiple processors for each of the functions warrants detailed experimentation. In this study, some of the functions of Unified Threat Management are implemented using multiple processors for each of the functions. Approach: This evaluation was conducted on SunfireT1000 server having Sun Ultras ARC T1 multicore processor. OpenMP parallelization methods are used for scheduling the logical CPUs for the parallelized application. Results: Execution time for some of the UTM functions implemented was analyzed to arrive at an effective allocation and parallelization methodology that is dependent on the hardware and the workload. Conclusion/Recommendations: Based on the analysis, the type of parallelization method for the implemented UTM functions are suggested.

  12. Dynamics systems vs. optimal control--a unifying view.

    Science.gov (United States)

    Schaal, Stefan; Mohajerian, Peyman; Ijspeert, Auke

    2007-01-01

    In the past, computational motor control has been approached from at least two major frameworks: the dynamic systems approach and the viewpoint of optimal control. The dynamic system approach emphasizes motor control as a process of self-organization between an animal and its environment. Nonlinear differential equations that can model entrainment and synchronization behavior are among the most favorable tools of dynamic systems modelers. In contrast, optimal control approaches view motor control as the evolutionary or development result of a nervous system that tries to optimize rather general organizational principles, e.g., energy consumption or accurate task achievement. Optimal control theory is usually employed to develop appropriate theories. Interestingly, there is rather little interaction between dynamic systems and optimal control modelers as the two approaches follow rather different philosophies and are often viewed as diametrically opposing. In this paper, we develop a computational approach to motor control that offers a unifying modeling framework for both dynamic systems and optimal control approaches. In discussions of several behavioral experiments and some theoretical and robotics studies, we demonstrate how our computational ideas allow both the representation of self-organizing processes and the optimization of movement based on reward criteria. Our modeling framework is rather simple and general, and opens opportunities to revisit many previous modeling results from this novel unifying view.

  13. A Unified Approach for Developing Efficient Algorithmic Programs

    Institute of Scientific and Technical Information of China (English)

    薛锦云

    1997-01-01

    A unified approach called partition-and-recur for developing efficient and correct algorithmic programs is presented.An algorithm(represented by recurrence and initiation)is separated from program,and special attention is paid to algorithm manipulation rather than proram calculus.An algorithm is exactly a set of mathematical formulae.It is easier for formal erivation and proof.After getting efficient and correct algorithm,a trivial transformation is used to get a final rogram,The approach covers several known algorithm design techniques,e.g.dynamic programming,greedy,divide-and-conquer and enumeration,etc.The techniques of partition and recurrence are not new.Partition is a general approach for dealing with complicated objects and is typically used in divide-and-conquer approach.Recurrence is used in algorithm analysis,in developing loop invariants and dynamic programming approach.The main contribution is combining two techniques used in typical algorithm development into a unified and systematic approach to develop general efficient algorithmic programs and presenting a new representation of algorithm that is easier for understanding and demonstrating the correctness and ingenuity of algorithmicprograms.

  14. A unified impulse response model for DCE-MRI.

    Science.gov (United States)

    Schabel, Matthias C

    2012-11-01

    We describe the gamma capillary transit time model, a generalized impulse response model for DCE-MRI that mathematically unifies the Tofts-Kety, extended Tofts-Kety, adiabatic tissue homogeneity, and two-compartment exchange models. By including a parameter (α⁻¹) representing the width of the distribution of capillary transit times within a tissue voxel, the GCTT model discriminates tissues having relatively monodisperse transit time distributions from those having a large degree of heterogeneity. All five models were compared using in vivo data acquired in three brain tumors (one glioblastoma multiforme, one pleomorphic xanthoastrocytoma, and one anaplastic meningioma) and Monte Carlo simulations. Our principal findings are : (1) The four most commonly used models for dynamic contrast-enhanced magnetic resonance imaging can be unified within a single formalism. (2) Application of the GCTT model to in vivo data incurs only modest penalties in parameter uncertainty and computational cost. (3) Measured nonparametric impulse response functions in human brain tumors are well described by the GCTT model. (4) Estimation of α⁻¹ is feasible but achieving statistical significance requires higher SNR than is typically obtained in single voxel dynamic contrast-enhanced magnetic resonance imaging data. These results suggest that the GCTT model may be useful for extraction of information about tumor physiology beyond what is obtained using current modeling methodologies.

  15. An Unified Approach for Process Quality Analysis and Control

    Directory of Open Access Journals (Sweden)

    Prof.Chandrakanth Biradar,Aruna Kawdi

    2012-09-01

    Full Text Available Abstract— The process in a company finally results in product of the company, which represents the company standard. Hence, during the process execution time quality of the process needs to be taken care before and after the work done. In this paper, an unified approach to quality analysis and control of a process development is presented. This approach gives an overview of what the task the company assigned to the employers. The process is defined as the set of action items to achieve the work completion. Quality means grade of excellence. Quality analysis of a process is an improvement of the process and making sure that all the standard procedures are followed. An unified approach designed in this paper is a combination of software cost estimation and a financial market forecasting with the support of historical data, statistical data mining technique and artificial neural networks, which helps the developers as well as investors in strategic planning and investment decision making. Therefore, the paper describes a recommended process to develop software (SW cost estimates for software managers, perform financial market forecasting to control quality of process development. As a result, the improvement and analysis of the process quality can be performed from basic level to the corporate level. By this work, we conclude that the process quality control can be made easier and efficient compared to the old graphical analytics technique.

  16. Microphysics in Multi-scale Modeling System with Unified Physics

    Science.gov (United States)

    Tao, Wei-Kuo

    2012-01-01

    Recently, a multi-scale modeling system with unified physics was developed at NASA Goddard. It consists of (1) a cloud-resolving model (Goddard Cumulus Ensemble model, GCE model), (2) a regional scale model (a NASA unified weather research and forecast, WRF), (3) a coupled CRM and global model (Goddard Multi-scale Modeling Framework, MMF), and (4) a land modeling system. The same microphysical processes, long and short wave radiative transfer and land processes and the explicit cloud-radiation, and cloud-land surface interactive processes are applied in this multi-scale modeling system. This modeling system has been coupled with a multi-satellite simulator to use NASA high-resolution satellite data to identify the strengths and weaknesses of cloud and precipitation processes simulated by the model. In this talk, a review of developments and applications of the multi-scale modeling system will be presented. In particular, the microphysics development and its performance for the multi-scale modeling system will be presented.

  17. A Unified Approach to Model-Based Planning and Execution

    Science.gov (United States)

    Muscettola, Nicola; Dorais, Gregory A.; Fry, Chuck; Levinson, Richard; Plaunt, Christian; Norvig, Peter (Technical Monitor)

    2000-01-01

    Writing autonomous software is complex, requiring the coordination of functionally and technologically diverse software modules. System and mission engineers must rely on specialists familiar with the different software modules to translate requirements into application software. Also, each module often encodes the same requirement in different forms. The results are high costs and reduced reliability due to the difficulty of tracking discrepancies in these encodings. In this paper we describe a unified approach to planning and execution that we believe provides a unified representational and computational framework for an autonomous agent. We identify the four main components whose interplay provides the basis for the agent's autonomous behavior: the domain model, the plan database, the plan running module, and the planner modules. This representational and problem solving approach can be applied at all levels of the architecture of a complex agent, such as Remote Agent. In the rest of the paper we briefly describe the Remote Agent architecture. The new agent architecture proposed here aims at achieving the full Remote Agent functionality. We then give the fundamental ideas behind the new agent architecture and point out some implication of the structure of the architecture, mainly in the area of reactivity and interaction between reactive and deliberative decision making. We conclude with related work and current status.

  18. Racial Diversity, Student Religiosity, and School Choice: An Empirical Case Study of Multi-Racial Religious Education

    Science.gov (United States)

    Reichard, Joshua D.

    2014-01-01

    This article comprises an empirical case study of student religiosity in the context of urban school choice. The purpose of this study was to compare student religiosity in a racially diverse religious private school to determine whether religious faith is a unifying factor across racial categories. Insofar as school choice has been called…

  19. Alternatives to the School-to-Prison Pipeline: The Role of Educational Leaders in Developing a College-Going Culture

    Science.gov (United States)

    Fujimoto, Eugene; Garcia, Yvonne; Medina, Noemy; Perez, Eduardo

    2013-01-01

    As the largest and fastest growing racial/ethnic group in the country, Latinos' educational success is a national priority. In the Los Angeles Unified School district, the country's largest, high school graduating rates for Latinos hover at near 40%. Examining this institutional and societal tragedy through the school-to-prison pipeline has…

  20. The unified equation by the Proportion 19 (-1:3

    Directory of Open Access Journals (Sweden)

    Vinoo Cameron

    2013-03-01

    Full Text Available As mankind is created in the image of a creator, the mathematical continuum is understandably connected, not by “Strings”, but by rational coordinates of mathematics. That is what this manuscript is all about; the rationalization of the natural expanse of mathematics and the stark reality of -1. The section on the mathematical PI (π clearly proves the -1 constriction of 4-1. Definition of the Unified Theorem: “The ascension and expansion of all space (and mass is curved, spiral and warped because of the -1 zero inverse primordial constriction of all space by -1. 4-(1 =+3. Bounded space is inverse at -1, a non-collapsible curve. The value of -1 is -1 for numbers and 0.5/60(1/120 for non-linear space. The minus 1 is manifested at proportion 19 as a composite of the of the values 9 and 10, both by numbers and prime angle (1:3. The proof of -1 is and has always been in the mathematical Pi (π, corrected trigonometry, and the spiral curved ascension of Prime numbers.” This proof is clearly stated under the section for the “mathematical Pi (π where the author has clearly proven -1 by theorem.” This manuscript has been preceded by several manuscripts on Prime numbers, -1 and Prime number 19 that show the unified mathematics as a consequence of a -1 Vedic zero, and the overall -1 ( 4-3 . As the treatise on the Unified Theorem, this is all written by simple theorem .This manuscript completely disregards current mathematical theory with regard to non- linear mathematics as irrelevant to mathematics. The clear assertion is that the -1 Vedic zeros is the correct zero, but that the current null zero is in error. The inverse curved value off-set of -1 is the value that precedes the +1 value, and it is clearly stated by this author that mathematically a curve cannot ever be collapsed to null. There is no logical compromise in this regard. Essentially and mathematically the author validates the primordial -1, and the absolute primordial value of

  1. Unified characteristics line theory of spacial axisymmetric plastic problem

    Institute of Scientific and Technical Information of China (English)

    YU; Maohong; (

    2001-01-01

    [1]Johnson, W., Sowerby, R., Venter, R. D., Plane Strain Slip Line Fields for Metal Deformation Processes——A Source Book and Bibliography, New York: Pergamon Press, 1982.[2]Hill, R., The Mathematical Theory of Plasticity, Oxford: Oxford University Press, 1950.[3]Sokolovsky, V. V., Theory of Plasticity(in Russia), Moskow: Nat. Tech. Press, 1950.[4]Kachanov, L. M., Foundations Theory of Plasticity, London: North-Holland, 1975.[5]Shield, R. T., On the plastic flow of metal condition of axial symmetry, Proc. Roy. Soc., 1955, 233A: 267.[6]Lippmann, H., IUTAM Symposium on Metal Forming Plasticity, New York: Springer-Verlag, 1979.[7]Spencer, A. J. M., The approximate solution of certain problem of axially-symmetric plastic flow, J. Mech. Phys. Solids, 1964, 12: 231.[8]Wang, R., Xiong, Z. H., Wang, W. B., Foundation of Plasticity (in Chinese), Beijing: Science Press, 1982.[9]Collins, I. E., Dewhurst, P., A slip line field analysis of asymmetrical hot rolling, International Journal of Mechanical Science, 1975, 17: 643.[10]Collins, I. F., Slip line field analysis of forming processes in plane strain and axial symmetry, Advanced Technology of Plasticity, 1984, 11: 1074.[11]Yu, M. H., Yang, S. Y., Liu, C. Y. et al., Unified plane-strain slip line field theory system, J. Civil Engineering (in Chinese), 1997, 30(2): 14[12]Simmons, J. A., Hauser, F., Dorn, E., Mathematical Theories of Plastic Deformation Under Impulsive Loading, Berkeley-Los Angeles: University of California Press, 1962.[13]Lin, C. C., On a perturbation theory based on the method of characteristies, J. Math. Phys., 1954, 33: 117—134.[14]Hopkins, H. G., The method of characteristics and its applications to the theory of stress waver in solids, in Engineering Plasticity, Combridge: Combridge University Press, 1968, 277—315.[15]Shield, R. T., The plastic indentation of a layer by a flat punch, Quart. Appl. Math., 1955, 13: 27.[16]Haar, A., von

  2. Project 10 Handbook: Addressing Lesbian and Gay Issues in Our Schools. A Resource Directory for Teachers, Guidance Counselors, Parents and School-Based Adolescent Care Providers. Third Edition.

    Science.gov (United States)

    Friends of Project 10, Inc.

    This handbook was developed by Project 10, an on-campus counseling program within the Los Angeles (California) Unified School District. The handbook covers many of the issues and problems that arise for homosexual high school students. Introductory material includes a history of the informal beginnings of Project 10. The first chapter describes…

  3. Prevalence and factors associated with Metabolic Syndrome in elderly users of the Unified Health System

    Directory of Open Access Journals (Sweden)

    Edna Cunha Vieira

    2014-12-01

    Full Text Available OBJECTIVE: To evaluate the prevalence and factors associated with metabolic syndrome in the elderly. METHODS: Cross-sectional study, with 133 individuals randomly selected in the Unified Health System in Goiania, Goiás. The following variables were researched: anthropometric (BMI, waist circumference, fat percentage by Dual X-ray absorptiometry, sociodemographic (gender, age, color, income, marital status and years of schooling, lifestyle (physical activity, smoking and risk alcohol consumption and food intake (risk and protective foods. The metabolic syndrome was assessed according to harmonized criteria proposed by the World Health Organization (WHO. The combinations were tested by Poisson regression for confounding factors. RESULTS: The prevalence of metabolic syndrome was 58.65% (95%CI 49.8 - 67.1, with 60.5% (95%CI 49.01 - 71.18 for females and 55.7% (95%CI 41.33 - 69.53 for males. Hypertension was the most prevalent component of the syndrome in both men, with 80.8% (95%CI 64.5 - 90.4, and women, with 85.2% (95%CI 75.5 - 92.1. After the multivariate analysis, only the excess of weight measured by body mass index (prevalence ratio = 1.66; p < 0.01 remained associated with the metabolic syndrome. CONCLUSIONS: The prevalence of metabolic syndrome in this sample was high, indicating the need for systematic actions by health workers in the control of risk factors through prevention strategies and comprehensive care to the elderly.

  4. A Unified Building Model for 3D Urban GIS

    Directory of Open Access Journals (Sweden)

    Ihab Hijazi

    2012-07-01

    Full Text Available Several tasks in urban and architectural design are today undertaken in a geospatial context. Building Information Models (BIM and geospatial technologies offer 3D data models that provide information about buildings and the surrounding environment. The Industry Foundation Classes (IFC and CityGML are today the two most prominent semantic models for representation of BIM and geospatial models respectively. CityGML has emerged as a standard for modeling city models while IFC has been developed as a reference model for building objects and sites. Current CAD and geospatial software provide tools that allow the conversion of information from one format to the other. These tools are however fairly limited in their capabilities, often resulting in data and information losses in the transformations. This paper describes a new approach for data integration based on a unified building model (UBM which encapsulates both the CityGML and IFC models, thus avoiding translations between the models and loss of information. To build the UBM, all classes and related concepts were initially collected from both models, overlapping concepts were merged, new objects were created to ensure the capturing of both indoor and outdoor objects, and finally, spatial relationships between the objects were redefined. Unified Modeling Language (UML notations were used for representing its objects and relationships between them. There are two use-case scenarios, both set in a hospital: “evacuation” and “allocating spaces for patient wards” were developed to validate and test the proposed UBM data model. Based on these two scenarios, four validation queries were defined in order to validate the appropriateness of the proposed unified building model. It has been validated, through the case scenarios and four queries, that the UBM being developed is able to integrate CityGML data as well as IFC data in an apparently seamless way. Constraints and enrichment functions are

  5. A Unified Field Theory of Gravity, Electromagnetism, and theA Unified Field Theory of Gravity, Electromagnetism, and the Yang-Mills Gauge Field

    Directory of Open Access Journals (Sweden)

    Suhendro I.

    2008-01-01

    Full Text Available In this work, we attempt at constructing a comprehensive four-dimensional unified field theory of gravity, electromagnetism, and the non-Abelian Yang-Mills gauge field in which the gravitational, electromagnetic, and material spin fields are unified as intrinsic geometric objects of the space-time manifold $S_4$ via the connection, with the generalized non-Abelian Yang-Mills gauge field appearing in particular as a sub-field of the geometrized electromagnetic interaction.

  6. Collaboration Among Educators: An Essential Step in Unifying STEM Teaching Resources.

    Science.gov (United States)

    McIver, H.; Ellins, K. K.; Bohls-Graham, C. E.; O'dell, D.; Sergent, C.; Jacobs, B. E.; Stocks, E.; Serpa, L. F.; Riggs, E. M.

    2015-12-01

    Increased requirement for Science, Engineering, Technology, and Math (STEM) literacy among US secondary school students has enhanced the need for high-quality teaching resources in the modern STEM classroom. Many relevant resources exist online that could be used to address this issue, but too often these resources are spread throughout the Internet, and have not necessarily been audited for content, alignment with state and national science standards, or current functionality. Because STEM subjects are increasingly difficult to teach, we set out to design a localized platform of year-long teaching 'blueprints' comprising units that cover a range of Earth science topics, researched and compiled by education professionals. The Diversity and Innovation for Geosciences (DIG) Texas Instructional Blueprint project has united teachers from diverse science backgrounds who act as Education Interns and work alongside geoscientists and curriculum experts at the University of Texas Jackson School of Geosciences, Texas A&M University and the University of Texas El Paso. Our DIG collective has employed a cross-disciplinary approach to vetting resources while compiling them in useful, logical sequences for classroom instruction. The DIG team has aligned each blueprint with the Texas Essential Skills and Knowledge (TEKS) standards for Earth and Space Science, the Earth Science Literacy Principles, and the Next Generation Science Standards. Emphasis for the summer 2015 project group was placed upon (1) alignment of the units with these three sets of science standards to allow for use within disparate classroom settings, (2) creating teacher aides including scaffolding notes for practical unit application, and potential real and virtual field trips for unit illustration, and (3) final vetting ensuring units follow a narrative that carries learners from basic principles to a full concept understanding. Here, we present our progress and the essential workflow that has contributed to

  7. Concepções e práticas pedagógicas nas escolas técnicas do Sistema Único de Saúde: fundamentos e contradições Conceptions and teaching practices in the technical schools of the Unified Health System: foundation and contradictions

    Directory of Open Access Journals (Sweden)

    Marise Ramos

    2009-01-01

    Full Text Available O presente artigo apresenta resultados empíricos de pesquisa sobre as concepções e práticas das Escolas Técnicas do Sistema Único de Saúde (ET-SUS, influenciadas pelas políticas de educação profissional em saúde dos anos 1980 aos 2000 pelo Ministério da Saúde, a saber: Projeto Larga Escala, Programa de Profissionalização dos Auxiliares de Enfermagem (Profae e Política de Educação Permanente. Tendo como base as correntes pedagógicas que estiveram em disputa no âmbito dessas políticas, apresenta-se a análise do material empírico qualitativo, composto por textos acadêmicos coletados com a revisão de literatura. Outra fonte empírica foram entrevistas realizadas com coordenadores pedagógicos, com as quais procuramos identificar dimensões do nosso objeto que se revelam na interação com os sujeitos da pesquisa. O material escrito foi submetido à análise de conteúdo, seguida da análise histórico-dialética, com base na categoria 'relação teoria-prática'. Procuramos captar as principais contradições que dificultam ou potencializam a educação profissional em saúde no sentido da emancipação da classe trabalhadora. A contraposição entre o pragmatismo e a filosofia da práxis foi a base dessa análise. As conclusões deste texto tratam dessas contradições, dialogando com a concepção de educação politécnica que tem o trabalho como princípio educativo, orientada para a práxis social transformadora.This article presents the empirical results of research on the concepts and practices of the Technical Schools of the National Health System (SUS-ET, influenced by the policies of professional education in health from the 1980's to the 2000's by the Ministry of Health, namely: large scale project, Program of training of Nursing Assistants (Profae and long-term educational policy. Based on the current teaching that is in dispute under such policies, an analysis is presented of qualitative empirical material

  8. Transfinite element methodology towards a unified thermal/structural analysis

    Science.gov (United States)

    Tamma, K. K.; Railkar, S. B.

    1986-01-01

    The paper describes computational developments towards thermal/structural modeling and analysis via a generalized common numerical methodology for effectively and efficiently interfacing interdisciplinary areas. The proposed formulations use transform methods in conjunction with finite element developments for each of the heat transfer and structural disciplines, respectively, providing avenues for obtaining the structural response due to thermal effects. An alternative methodology for unified thermal/structural analysis is presented. The potential of the approach is outlined in comparison with conventional schemes and existing practices. Highlights and characteristic features of the approach are described via general formulations and applications to several problems. Results obtained demonstrate excellent agreement in comparison with analytic and/or conventional finite element schemes accurately and efficiently.

  9. Artificial Intelligence Based Three-Phase Unified Power Quality Conditioner

    Directory of Open Access Journals (Sweden)

    Moleykutty George

    2007-01-01

    Full Text Available Power quality is an important measure of the performance of an electrical power system. This paper discusses the topology, control strategies using artificial intelligent (AI based controllers and the performance of a unified power quality conditioner (UPQC for power quality improvement. UPQC is an integration of shunt and series compensation to limit the harmonic contamination within 5 %, the limit imposed by IEEE-519 standard. The novelty of this paper lies in the application of neural network control (NNC algorithms such as model reference control (MRC, and nonlinear autoregressive-moving average (NARMA–L2 control to generate switching signals for the series compensator of the UPQC system. The entire system has been modeled using MATLAB 7.0 toolbox. Simulation results demonstrate the applicability of MRC and NARMA-L2 controllers for the control of UPQC.

  10. Ontology development for unified traditional Chinese medical language system.

    Science.gov (United States)

    Zhou, Xuezhong; Wu, Zhaohui; Yin, Aining; Wu, Lancheng; Fan, Weiyu; Zhang, Ruen

    2004-09-01

    Traditional Chinese medicine (TCM) as a complete knowledge system researches into human health conditions via a different approach compared to orthodox medicine. We are developing a unified traditional Chinese medical language system (UTCMLS) through an ontology approach that will support TCM language knowledge storage, concept-based information retrieval and information integration. UTCMLS is a huge knowledge project, which is a broad collaboration of 16 distributed groups, most of them with no prior experience of formal ontology development. Therefore, the cooperative and comprehensive ontology engineering is crucial. We use Protégé 2000 for ontology development of concepts and relationships that represent the domain and that will permit storage of TCM knowledge. This paper focuses on the methodology, design and development of ontology for UTCMLS.

  11. A Unified Approach to High-Gain Adaptive Controllers

    Directory of Open Access Journals (Sweden)

    Ian A. Gravagne

    2009-01-01

    Full Text Available It has been known for some time that proportional output feedback will stabilize MIMO, minimum-phase, linear time-invariant systems if the feedback gain is sufficiently large. High-gain adaptive controllers achieve stability by automatically driving up the feedback gain monotonically. More recently, it was demonstrated that sample-and-hold implementations of the high-gain adaptive controller also require adaptation of the sampling rate. In this paper, we use recent advances in the mathematical field of dynamic equations on time scales to unify and generalize the discrete and continuous versions of the high-gain adaptive controller. We prove the stability of high-gain adaptive controllers on a wide class of time scales.

  12. A New Finslerian Unified Field Theory of Physical Interactions

    Directory of Open Access Journals (Sweden)

    Suhendro I.

    2009-10-01

    Full Text Available In this work, we shall present the foundational structure of a new unified field theory of physical interactions in a geometric world-space endowed with a new kind of Finslerian metric. The intrinsic non-metricity in the structure of our world-geometry may have direct, genuine connection with quantum mechanics, which is yet to be fully explored at present. Building upon some of the previous works of the Author, our ultimate aim here is yet another quantum theory of gravity (in just four space-time dimensions. Our resulting new theory appears to present us with a novel Eulerian (intrinsically motion-dependent world-geometry in which the physical fields originate.

  13. Perturbative estimates of lepton mixing angles in unified models

    Energy Technology Data Exchange (ETDEWEB)

    Antusch, Stefan [Max-Planck-Institut fuer Physik (Werner-Heisenberg-Institut), Foehringer Ring 6, 80805 Muenchen (Germany)], E-mail: antusch@mppmu.mpg.de; King, Stephen F. [School of Physics and Astronomy, University of Southampton, Southampton, SO17 1BJ (United Kingdom); Malinsky, Michal [Department of Theoretical Physics, School of Engineering Sciences, Royal Institute of Technology (KTH) - AlbaNova University Center, Roslagstullsbacken 21, SE-106 91 Stockholm (Sweden)

    2009-10-11

    Many unified models predict two large neutrino mixing angles, with the charged lepton mixing angles being small and quark-like, and the neutrino masses being hierarchical. Assuming this, we present simple approximate analytic formulae giving the lepton mixing angles in terms of the underlying high energy neutrino mixing angles together with small perturbations due to both charged lepton corrections and renormalisation group (RG) effects, including also the effects of third family canonical normalization (CN). We apply the perturbative formulae to the ubiquitous case of tri-bimaximal neutrino mixing at the unification scale, in order to predict the theoretical corrections to mixing angle predictions and sum rule relations, and give a general discussion of all limiting cases. We also discuss the implications for the sum rule relations of the measurement of a non-zero reactor angle, as hinted at by recent experimental measurements.

  14. Adaptive Unified Biased Estimators of Parameters in Linear Model

    Institute of Scientific and Technical Information of China (English)

    Hu Yang; Li-xing Zhu

    2004-01-01

    To tackle multi collinearity or ill-conditioned design matrices in linear models,adaptive biased estimators such as the time-honored Stein estimator,the ridge and the principal component estimators have been studied intensively.To study when a biased estimator uniformly outperforms the least squares estimator,some suficient conditions are proposed in the literature.In this paper,we propose a unified framework to formulate a class of adaptive biased estimators.This class includes all existing biased estimators and some new ones.A suficient condition for outperforming the least squares estimator is proposed.In terms of selecting parameters in the condition,we can obtain all double-type conditions in the literature.

  15. Towards a unified fatigue life prediction method for marine structures

    CERN Document Server

    Cui, Weicheng; Wang, Fang

    2014-01-01

    In order to apply the damage tolerance design philosophy to design marine structures, accurate prediction of fatigue crack growth under service conditions is required. Now, more and more people have realized that only a fatigue life prediction method based on fatigue crack propagation (FCP) theory has the potential to explain various fatigue phenomena observed. In this book, the issues leading towards the development of a unified fatigue life prediction (UFLP) method based on FCP theory are addressed. Based on the philosophy of the UFLP method, the current inconsistency between fatigue design and inspection of marine structures could be resolved. This book presents the state-of-the-art and recent advances, including those by the authors, in fatigue studies. It is designed to lead the future directions and to provide a useful tool in many practical applications. It is intended to address to engineers, naval architects, research staff, professionals and graduates engaged in fatigue prevention design and survey ...

  16. Dependence as a unifying construct in defining Alzheimer's disease severity.

    Science.gov (United States)

    McLaughlin, Trent; Feldman, Howard; Fillit, Howard; Sano, Mary; Schmitt, Frederick; Aisen, Paul; Leibman, Christopher; Mucha, Lisa; Ryan, J Michael; Sullivan, Sean D; Spackman, D Eldon; Neumann, Peter J; Cohen, Joshua; Stern, Yaakov

    2010-11-01

    This article reviews measures of Alzheimer's disease (AD) progression in relation to patient dependence and offers a unifying conceptual framework for dependence in AD. Clinicians typically characterize AD by symptomatic impairments in three domains: cognition, function, and behavior. From a patient's perspective, changes in these domains, individually and in concert, ultimately lead to increased dependence and loss of autonomy. Examples of dependence in AD range from a need for reminders (early AD) to requiring safety supervision and assistance with basic functions (late AD). Published literature has focused on the clinical domains as somewhat separate constructs and has given limited attention to the concept of patient dependence as a descriptor of AD progression. This article presents the concept of dependence on others for care needs as a potential method for translating the effect of changes in cognition, function, and behavior into a more holistic, transparent description of AD progression.

  17. High magnetic field pulsars and magnetars a unified picture

    CERN Document Server

    Zhang, B; Zhang, Bing; Harding, Alice K.

    2000-01-01

    We propose a unified picture of high magnetic field radio pulsars and magnetars by arguing that they are all rotating high-field neutron stars, but have different orientations of their magnetic axes with respective to their rotation axes. In strong magnetic fields where photon splitting suppresses pair creation near the surface, the high-field pulsars can have active inner accelerators while the anomalous X-ray pulsars cannot. This can account for the very different observed emission characteristics of the anomalous X-ray pulsar 1E 2259+586 and the high field radio pulsar PSR J1814-1744. A predicted consequence of this picture is that radio pulsars having surface magnetic field greater than about $2\\times 10^{14}$ G should not exist.

  18. Molecular catalysis science: Perspective on unifying the fields of catalysis.

    Science.gov (United States)

    Ye, Rong; Hurlburt, Tyler J; Sabyrov, Kairat; Alayoglu, Selim; Somorjai, Gabor A

    2016-05-10

    Colloidal chemistry is used to control the size, shape, morphology, and composition of metal nanoparticles. Model catalysts as such are applied to catalytic transformations in the three types of catalysts: heterogeneous, homogeneous, and enzymatic. Real-time dynamics of oxidation state, coordination, and bonding of nanoparticle catalysts are put under the microscope using surface techniques such as sum-frequency generation vibrational spectroscopy and ambient pressure X-ray photoelectron spectroscopy under catalytically relevant conditions. It was demonstrated that catalytic behavior and trends are strongly tied to oxidation state, the coordination number and crystallographic orientation of metal sites, and bonding and orientation of surface adsorbates. It was also found that catalytic performance can be tuned by carefully designing and fabricating catalysts from the bottom up. Homogeneous and heterogeneous catalysts, and likely enzymes, behave similarly at the molecular level. Unifying the fields of catalysis is the key to achieving the goal of 100% selectivity in catalysis.

  19. A unified approach for least-squares surface fitting

    Institute of Scientific and Technical Information of China (English)

    ZHU; Limin; DING; Han

    2004-01-01

    This paper presents a novel approach for least-squares fitting of complex surface to measured 3D coordinate points by adjusting its location and/or shape. For a point expressed in the machine reference frame and a deformable smooth surface represented in its own model frame, a signed point-to-surface distance function is defined,and its increment with respect to the differential motion and differential deformation of the surface is derived. On this basis, localization, surface reconstruction and geometric variation characterization are formulated as a unified nonlinear least-squares problem defined on the product space SE(3)×m. By using Levenberg-Marquardt method, a sequential approximation surface fitting algorithm is developed. It has the advantages of implementational simplicity, computational efficiency and robustness. Applications confirm the validity of the proposed approach.

  20. A unified model in the pulsed laser ablation process

    Institute of Scientific and Technical Information of China (English)

    HU De-zhi

    2008-01-01

    In this unified model, we introduce the electron-phonon coupling time (t) and laser pulse width (t). For long pulses, it can substitute for the traditional thermal conduction model; while for ultrashort pulses, it can substitute for the standard two-temperature model. As an example of the gold target, we get the dependence of the electron and ion temperature evolvement on the time and position by solving the thermal conduction equation using the finite-difference time-domain (FDTD) method.It is in good agreement with experimental data. We obtain the critical temperature of the onset of ablation using the Saha equation and then obtain the theoretical value of the laser ablation threshold when the laser pulse width ranges from nanosecond to femtosecond timescale, which consists well with the experimental data.

  1. Higher-Dimensional Unified Theories with Fuzzy Extra Dimensions

    Directory of Open Access Journals (Sweden)

    Athanasios Chatzistavrakidis

    2010-08-01

    Full Text Available Theories defined in higher than four dimensions have been used in various frameworks and have a long and interesting history. Here we review certain attempts, developed over the last years, towards the construction of unified particle physics models in the context of higher-dimensional gauge theories with non-commutative extra dimensions. These ideas have been developed in two complementary ways, namely (i starting with a higher-dimensional gauge theory and dimensionally reducing it to four dimensions over fuzzy internal spaces and (ii starting with a four-dimensional, renormalizable gauge theory and dynamically generating fuzzy extra dimensions. We describe the above approaches and moreover we discuss the inclusion of fermions and the construction of realistic chiral theories in this context.

  2. On the Feasibility of a Unified Modelling and Programming Paradigm

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth; Peleska, Jan

    2016-01-01

    In this article, the feasibility of a unified modelling and programming paradigm is discussed from the perspective of large scale system development and verification in collaborative development environments. We motivate the necessity to utilise multiple formalisms for development and verification......, in particular for complex cyber-physical systems or systems of systems. Though modelling, programming, and verification will certainly become more closely integrated in the future, we do not expect a single formalism to become universally applicable and accepted by the development and verification communities....... It is illustrated by means of a case study from the railway domain, how this can be achieved, using concepts from the theory of institutions. This also enables the utilisation of verification tools in different formalisms, despite the fact that these tools are usually developed for one specific formal method....

  3. Computing an operating parameter of a unified power flow controller

    Science.gov (United States)

    Wilson, David G; Robinett, III, Rush D

    2015-01-06

    A Unified Power Flow Controller described herein comprises a sensor that outputs at least one sensed condition, a processor that receives the at least one sensed condition, a memory that comprises control logic that is executable by the processor; and power electronics that comprise power storage, wherein the processor causes the power electronics to selectively cause the power storage to act as one of a power generator or a load based at least in part upon the at least one sensed condition output by the sensor and the control logic, and wherein at least one operating parameter of the power electronics is designed to facilitate maximal transmittal of electrical power generated at a variable power generation system to a grid system while meeting power constraints set forth by the electrical power grid.

  4. Impaired integration in psychopathy: A unified theory of psychopathic dysfunction.

    Science.gov (United States)

    Hamilton, Rachel K B; Hiatt Racer, Kristina; Newman, Joseph P

    2015-10-01

    This article introduces a novel theoretical framework for psychopathy that bridges dominant affective and cognitive models. According to the proposed impaired integration (II) framework of psychopathic dysfunction, topographical irregularities and abnormalities in neural connectivity in psychopathy hinder the complex process of information integration. Central to the II theory is the notion that psychopathic individuals are "'wired up' differently" (Hare, Williamson, & Harpur, 1988, p. 87). Specific theoretical assumptions include decreased functioning of the Salience and Default Mode Networks, normal functioning in executive control networks, and less coordination and flexible switching between networks. Following a review of dominant models of psychopathy, we introduce our II theory as a parsimonious account of behavioral and brain irregularities in psychopathy. The II theory provides a unified theoretical framework for understanding psychopathic dysfunction and integrates principle tenets of affective and cognitive perspectives. Moreover, it accommodates evidence regarding connectivity abnormalities in psychopathy through its network theoretical perspective. (PsycINFO Database Record

  5. The coherence problem with the Unified Neutral Theory of Biodiversity.

    Science.gov (United States)

    Clark, James S

    2012-04-01

    The Unified Neutral Theory of Biodiversity (UNTB), proposed as an alternative to niche theory, has been viewed as a theory that species coexist without niche differences, without fitness differences, or with equal probability of success. Support is claimed when models lacking species differences predict highly aggregated metrics, such as species abundance distributions (SADs) or species area distributions (SARs). Here, I summarize why UNTB generates confusion, and is not actually relevant to niche theory (i.e. an explanation for why and how many species coexist). Equal probability is not a theory, but lack of one; it does not include or exclude any process relevant to coexistence of competitors. Models lacking explicit species can make useful predictions, but this does not support neutral theory. I provide s suggestions that could help reduce confusion generated by the debate.

  6. Towards a unified theory of health-disease: II. Holopathogenesis.

    Science.gov (United States)

    Almeida Filho, Naomar

    2014-04-01

    This article presents a systematic framework for modeling several classes of illness-sickness-disease named as Holopathogenesis. Holopathogenesis is defined as processes of over-determination of diseases and related conditions taken as a whole, comprising selected facets of the complex object Health. First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial). Second, propositions derived from Holopathogenesis are introduced in order to allow drawing the disease-illness-sickness complex as a hierarchical network of networks. Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed. Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.

  7. Unified nonequilibrium dynamical theory for exchange bias and training effects

    Institute of Scientific and Technical Information of China (English)

    Zhang Kai-Cheng; Liu Bang-Gui

    2009-01-01

    We have investigated the exchange bias and training effect in the ferromagnetie/antiferromagnetic (FM/AF)heterostructures using a unified Monte Carlo dynamical approach. The magnetization of the uncompensated AF layer is still open after the first field cycling is finished. Our simulated results show obvious shift of hysteresis loops (exchange bias) and cycling dependence of exchange bias (training effect) when the temperature is below 45 K. The exchange bias field decreases with decreasing cooling rate or increasing temperature and the number of the field cycling. Essentially,these two effects can be explained on the basis of the microscopical coexistence of both reversible and irreversible moment reversals of the AF domains. Our simulations are useful to understand the real magnetization dynamics of such magnetic heterostructures.

  8. The free-energy principle: a unified brain theory?

    Science.gov (United States)

    Friston, Karl

    2010-02-01

    A free-energy principle has been proposed recently that accounts for action, perception and learning. This Review looks at some key brain theories in the biological (for example, neural Darwinism) and physical (for example, information theory and optimal control theory) sciences from the free-energy perspective. Crucially, one key theme runs through each of these theories - optimization. Furthermore, if we look closely at what is optimized, the same quantity keeps emerging, namely value (expected reward, expected utility) or its complement, surprise (prediction error, expected cost). This is the quantity that is optimized under the free-energy principle, which suggests that several global brain theories might be unified within a free-energy framework.

  9. A unified theory for the energy cost of legged locomotion.

    Science.gov (United States)

    Pontzer, Herman

    2016-02-01

    Small animals are remarkably efficient climbers but comparatively poor runners, a well-established phenomenon in locomotor energetics that drives size-related differences in locomotor ecology yet remains poorly understood. Here, I derive the energy cost of legged locomotion from two complementary components of muscle metabolism, Activation-Relaxation and Cross-bridge cycling. A mathematical model incorporating these costs explains observed patterns of locomotor cost both within and between species, across a broad range of animals (insects to ungulates), for a wide range of substrate slopes including level running and vertical climbing. This ARC model unifies work- and force-based models for locomotor cost and integrates whole-organism locomotor cost with cellular muscle physiology, creating a predictive framework for investigating evolutionary and ecological pressures shaping limb design and ranging behaviour.

  10. Human genetics of infectious diseases: a unified theory

    Science.gov (United States)

    Casanova, Jean-Laurent; Abel, Laurent

    2007-01-01

    Since the early 1950s, the dominant paradigm in the human genetics of infectious diseases postulates that rare monogenic immunodeficiencies confer vulnerability to multiple infectious diseases (one gene, multiple infections), whereas common infections are associated with the polygenic inheritance of multiple susceptibility genes (one infection, multiple genes). Recent studies, since 1996 in particular, have challenged this view. A newly recognised group of primary immunodeficiencies predisposing the individual to a principal or single type of infection is emerging. In parallel, several common infections have been shown to reflect the inheritance of one major susceptibility gene, at least in some populations. This novel causal relationship (one gene, one infection) blurs the distinction between patient-based Mendelian genetics and population-based complex genetics, and provides a unified conceptual frame for exploring the molecular genetic basis of infectious diseases in humans. PMID:17255931

  11. Unified Description of Charmonium Suppression in QGP Medium

    CERN Document Server

    Singh, Captain R; Ganesh, S; Mishra, M

    2015-01-01

    Recent experimental and theoretical studies suggest that the quarkonia suppression in a thermal QCD medium created at heavy ion collisions is a complex interplay of various physical processes. In this article we put together most of these processes in a unified way to calculate the charmonium survival probability (nuclear modification factor) at energies available at relativistic heavy ion collider (RHIC) and large hadron collider (LHC) experiments. We have included shadowing as the dominant cold nuclear matter (CNM) effect. Further, gluo-dissociation and collision damping has been included which provide width to the spectral function of charmonia in a thermal medium and causes the dissociation of charmonium along with usual colour screening. We include the colour screening using our recently proposed modified Chu and Matsui model. Furthermore we incorporate the recombination of uncorrelated charm and anti-charm quark for the regeneration of charmonium over the entire temporal evolution of QGP medium. Finally...

  12. A Unified Active Learning Framework for Biomedical Relation Extraction

    Institute of Scientific and Technical Information of China (English)

    Hong-Tao Zhang; Min-Lie Huang; Xiao-Yan Zhu

    2012-01-01

    Supervised machine learning methods have been employed with great success in the task of biomedical relation extraction.However,existing methods are not practical enough,since manual construction of large training data is very expensive.Therefore,active learning is urgently needed for designing practical relation extraction methods with little human effort.In this paper,we describe a unified active learning framework.Particularly,our framework systematically addresses some practical issues during active learning process,including a strategy for selecting informative data,a data diversity selection algorithm,an active feature acquisition method,and an informative feature selection algorithm,in order to meet the challenges due to the immense amount of complex and diverse biomedical text.The framework is evaluated on protein-protein interaction (PPI) extraction and is shown to achieve promising results with a significant reduction in editorial effort and labeling time.

  13. Unified picture of the oxygen isotope effect in cuprate superconductors.

    Science.gov (United States)

    Chen, Xiao-Jia; Struzhkin, Viktor V; Wu, Zhigang; Lin, Hai-Qing; Hemley, Russell J; Mao, Ho-kwang

    2007-03-06

    High-temperature superconductivity in cuprates was discovered almost exactly 20 years ago, but a satisfactory theoretical explanation for this phenomenon is still lacking. The isotope effect has played an important role in establishing electron-phonon interaction as the dominant interaction in conventional superconductors. Here we present a unified picture of the oxygen isotope effect in cuprate superconductors based on a phonon-mediated d-wave pairing model within the Bardeen-Cooper-Schrieffer theory. We show that this model accounts for the magnitude of the isotope exponent as functions of the doping level as well as the variation between different cuprate superconductors. The isotope effect on the superconducting transition is also found to resemble the effect of pressure on the transition. These results indicate that the role of phonons should not be overlooked for explaining the superconductivity in cuprates.

  14. Statistical Metadata: a Unified Approach to Management and Dissemination

    Directory of Open Access Journals (Sweden)

    Signore Marina

    2015-06-01

    Full Text Available This article illustrates a unified conceptual approach to metadata, whereby metadata describing the information content and structure of data and those describing the statistical process are managed jointly with metadata arising from administrative and support activities. Many different actors may benefit from this approach: internal users who are given the option to reuse information; internal management that is supported in the decision-making process, process industrialisation and standardisation as well as performance assessment; external users who are provided with data and process-related metadata as well as quality measures to retrieve data and use them properly. In the article, a general model useful for metadata representation is illustrated and its application presented. Relationships to existing frameworks and standards are also discussed and enhancements proposed.

  15. A Unified Algorithm for Finding the Intersection Curve of Surfaces

    Institute of Scientific and Technical Information of China (English)

    谭建荣; 郑建民; 等

    1994-01-01

    In this papaer,an INTEGRAL CURVE ALGORITHM is presented,which turns the intersection curve of surfaces into the form of integral one and then uses “PREDICTORCORRECTOR” technique to evaluate the intersection of surfaces.No matter how the surfaces are defined,the method always deals with the intersection curves in the same way.To find a point on the curve one need only to calculate the JACOBI determinants of “PREDICTOR point”and “CORRECTOR point” while the second order precision is guatanteed.Thus,not only is the problem of finding the intersection of surfaces resolved,but also the algorithms for generating both plane curve and space curve are unified.

  16. Horseshoe and entropy in a fractional-order unified system

    Science.gov (United States)

    Li, Qing-Du; Chen, Shu; Zhou, Ping

    2011-01-01

    This paper studies chaotic dynamics in a fractional-order unified system by means of topological horseshoe theory and numerical computation. First it finds four quadrilaterals in a carefully-chosen Poincaré section, then shows that the corresponding map is semiconjugate to a shift map with four symbols. By estimating the topological entropy of the map and the original time-continuous system, it provides a computer assisted verification on existence of chaos in this system, which is much more convincible than the common method of Lyapunov exponents. This new method can potentially be used in rigorous studies of chaos in such a kind of system. This paper may be a start for proving a given fractional-order differential equation to be chaotic.

  17. An intuitive and unified approach to teaching thermodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Cengel, Y.A. [Univ. of Nevada, Reno, NV (United States). Dept. of Mechanical Engineering

    1996-12-31

    In this paper a physical or intuitive approach is presented as an alternative to the current formula based approach to learning thermodynamics. In this paper, the authors attempt to demonstrate that the basic principles of thermodynamics can be taught with an intuitive and unified approach faster and better. This approach also instills a solid and long-lasting understanding of thermodynamics in students. The proposed approach is intended to supplement the current approaches instead of replacing it. It is most suitable during initial stages of study of energy, entropy, and exergy to establish the physical reasoning behind the formulas, and to help students develop a physical feel. The approach naturally leads into the convenient formula-based approach when the students reach that maturity.

  18. Rhythmic Degradation Explains and Unifies Circadian Transcriptome and Proteome Data

    Directory of Open Access Journals (Sweden)

    Sarah Lück

    2014-10-01

    Full Text Available The rich mammalian cellular circadian output affects thousands of genes in many cell types and has been the subject of genome-wide transcriptome and proteome studies. The results have been enigmatic because transcript peak abundances do not always follow the peaks of gene-expression activity in time. We posited that circadian degradation of mRNAs and proteins plays a pivotal role in setting their peak times. To establish guiding principles, we derived a theoretical framework that fully describes the amplitudes and phases of biomolecules with circadian half-lives. We were able to explain the circadian transcriptome and proteome studies with the same unifying theory, including cases in which transcripts or proteins appeared before the onset of increased production rates. Furthermore, we estimate that 30% of the circadian transcripts in mouse liver and Drosophila heads are affected by rhythmic posttranscriptional regulation.

  19. Unified framework of face hallucination across multiple modalities

    Science.gov (United States)

    Ma, Xiang; Liu, Junhui; Li, Wenmin

    2015-02-01

    Face hallucination in a single modality environment has been heavily studied, in real-world environments under multiple modalities is still in its early stage. This paper presents a unified framework to solve face hallucination problem across multiple modalities i.e. different expressions, poses, illuminations. Almost all of the state-of-the-art face superresolution methods only generate a single output with the same modality of the low-resolution input. Our proposed framework is able to generate multiple outputs of different new modalities from only a single low-resolution input. It includes a global transformation with diagonal loading for modeling the mappings among different new facial modalities, and a local position-patch based method with weights compensation for incorporating image details. Experimental results illustrate the superiority of our framework.

  20. A unified cooperative control architecture for UAV missions

    Science.gov (United States)

    Tian, Xin; Bar-Shalom, Yaakov; Chen, Genshe; Blasch, Erik; Pham, Khanh

    2012-06-01

    In this paper, we propose a unified cooperative control architecture (UCCA) that supports effective cooperation of Unmanned Aerial Vehicles (UAVs) and learning capabilities for UAV missions. Main features of the proposed UCCA include: i) it has a modular structure; each function module focuses on a particular type of task and provide services to other function modules through well defined interfaces; ii) it allows the efficient sharing of UAV control and onboard resources by the function modules and is able to effectively handle simultaneously multiple objectives in the UAV operation; iii) it facilitates the cooperation among different function modules; iv) it supports effective cooperation among multiple UAVs on a mission's tasks, v) an objective driven learning approach is also supported, which allows UAVs to systematically explore uncertain mission environments to increase the level of situation awareness for the achievement of their mission/task objectives.